id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319792-16upcncw	Zhu, Jieqing	Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors	2004-06-18		.txt	text/plain	2599	155	66	Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors Severe acute respiratory syndrome coronavirus (SARS-CoV) has been identified as a new distinct pathological entity [1] [2] [3] and the disease infected more than 8000 people and killed 774 worldwide, mostly in Asia, before it was brought under control in July between the winter and spring in 2002-2003 (WHO website: www.who.int). The genomic sequencing reveals that, as with other enveloped RNA viruses, including the coronaviruses [10] [11] [12] , SARS-CoV envelope spike (S) protein contains highly conserved heptad repeat regions (HR1 and HR2), which have been shown as important in virus membrane fusion and successfully used as targets for virus entry/fusion inhibitors in a number of viruses [13] [14] [15] [16] [17] [18] , including a coronavirus, mouse hepatitis virus (MHV) [12] .	./cache/cord-319792-16upcncw.txt	./txt/cord-319792-16upcncw.txt