id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-300731-i2ow33bk	Cowan, Fred M.	A Review of Multi-Threat Medical Countermeasures against Chemical Warfare and Terrorism	2004-11-17		.txt	text/plain	4471	270	35	Although sites and mechanisms of action and the pathologies caused by different chemical insults vary, common biochemical signaling pathways, molecular mediators, and cellular processes provide targets for MTMC drugs. The biochemical pathways associated with chemical toxicity can involve proteases, inflammatory cytokines such as tumor necrosis factor (TNF), interleukin (IL)-1, IL-8, and other molecules such as platelet activating factor (PAF), N-methyl-D-aspartate (NMDA) glutamate receptors, acetylcholine (ACh), substance P, and poly(ADP-ribose) polymerase (PARP) (for review, see Ref. 14). These mediators and receptors can influence inflammatory responses associated with cellular processes such as degranulation, apoptosis, and necrosis that contribute to pathologies caused by chemical agents. Therefore, many classes of compounds used as countermeasures to chemical warfare agents such as PARP inhibitors, proteases inhibitors, adenosine agonists, and NMDA receptor antagonist, although not chiefly thought of as anti-inflammatory drugs, have anti-inflammatory pharmacology (Table I ) (for review, see Ref. 14) .	./cache/cord-300731-i2ow33bk.txt	./txt/cord-300731-i2ow33bk.txt