id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273479-kira7mz6	Strike, Philip C.	Mild acute inflammatory stimulation induces transient negative mood	2004-10-02		.txt	text/plain	3765	209	49	METHODS: Using a double blind study design, 26 healthy volunteers underwent baseline assessments of mood, financial strain and work stress and were randomised to injection of Salmonella typhi vaccine or placebo injection. Increases in anxiety and depressed mood were reported over the same time-scale in the endotoxin group, and the changes were correlated with the magnitude of cytokine responses. In the light of the kinetics of proinflammatory cytokine responses observed in earlier studies, we hypothesised that compared with placebo, vaccination would induce transient negative moods in the 1 -4 h following treatment, in the absence of rises in systemic body temperature or symptoms of illness. Changes in symptoms, body temperature, blood pressure and heart rate over the study were analysed with repeated measures analysis of variance with group (vaccine, placebo) as the between-subject factor, and time (base, 1, 2, 3, 4, 6 and 8 h) as the within-subject factor.	./cache/cord-273479-kira7mz6.txt	./txt/cord-273479-kira7mz6.txt