id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254107-02bik024	Hillisch, Alexander	Utility of homology models in the drug discovery process	2004-08-31		.txt	text/plain	7374	374	43	The quality of these homology models, and thus their applicability to, for example, drug discovery, predominantly depends on the sequence similarity between the protein of known structure (template) and the protein to be modeled (target). In conjunction with homology models, Cengent Therapeutics (http://www.cengent.com) offers dynamic structural information generated from molecular dynamics simulations for 5500 human drug target proteins. If sequence identity is greater than ~50%, the resulting models are frequently of sufficient quality to be used in the prediction of detailed protein-ligand interactions, such as structure-based drug design and prediction of the preferred sites of metabolism of small molecules ( Figure 2 ). It has recently been shown that it is possible to design small molecules based on homology models and then to use these compounds as tools to study the physiological role of the respective target protein of that particular drug [31] .	./cache/cord-254107-02bik024.txt	./txt/cord-254107-02bik024.txt