id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252103-lsaa1nx0	Pearks Wilkerson, Alison J	Coronavirus outbreak in cheetahs: Lessons for SARS	2004-03-23		.txt	text/plain	956	52	54	To characterize the genomic disposition of the cheetahs' Aju-CoV strain, PCR primers based on alignment of seven coronavirus gene segments (pol1a, pol1b, S, M, N, 7a/7b, and 3′ ′UTR), were used to amplify cDNA from archived cheetah liver and kidney tissues collected during the Winston outbreak. The phylogenetic analyses indicate a close similarity of the Aju-CoV and the FCoV strains, suggesting the cheetah virus is closely related to, if not indistinguishable from, domestic cat isolates. Fourth, while mortality among humans with SARS symptoms and house cats with FCoV is low, around 5-10%, cheetahs with Aju-CoV exhibited the opposite extreme, showing 90% morbidity and over 60% mortality. If this hypothesis is correct, the greater genetic diversity of domestic cats and humans may reduce the severity of the epidemic, and also contribute to the occurrence of rare genetically determined SARS-CoV super-spreaders who can infect with high virulence.	./cache/cord-252103-lsaa1nx0.txt	./txt/cord-252103-lsaa1nx0.txt