id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006544-yr4u61qv	Miesbach, W.	Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation	2004-03-20		.txt	text/plain	3867	223	35	title: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation Over the preceding 3 years the patient had presented a wide spectrum of manifestations of APS, including recurrent venous and arterial thromboses, cardiac, gynecological (HELLP syndrome), neurological involvements, livedo reticularis, a mild thrombocytopenia and the most feared manifestation of the catastrophic antiphospholipid syndrome (CAPS). The antiphospholipid syndrome (APS) is one of the most common causes of acquired thrombophilia and is characterized by arterial and/or venous thrombosis, recurrent pregnancy losses, and the laboratory evidence of antibodies against phospholipids or phospholipidbinding protein cofactors [1] . Retrospective studies suggest that patients with APS have an increased risk of recurrent thromboembolism [4, 5, 6] , and for this reason it is recommended that they receive oral vitamin K antagonists, such as warfarin, in order to achieve an international normalized ratio (INR) range within a therapeutic level (INR fi 3).	./cache/cord-006544-yr4u61qv.txt	./txt/cord-006544-yr4u61qv.txt