id	sid	tid	token	lemma	pos
cord-321868-xk4yuibj	1	1	key	key	NN
cord-321868-xk4yuibj	1	2	:	:	:
cord-321868-xk4yuibj	2	1	cord-321868-xk4yuibj	cord-321868-xk4yuibj	NNS
cord-321868-xk4yuibj	3	1	authors	author	NNS
cord-321868-xk4yuibj	3	2	:	:	:
cord-321868-xk4yuibj	3	3	Belcourt	Belcourt	NNP
cord-321868-xk4yuibj	3	4	,	,	,
cord-321868-xk4yuibj	3	5	Michael	Michael	NNP
cord-321868-xk4yuibj	3	6	F.	F.	NNP
cord-321868-xk4yuibj	3	7	;	;	:
cord-321868-xk4yuibj	3	8	Farabaugh	Farabaugh	NNP
cord-321868-xk4yuibj	3	9	,	,	,
cord-321868-xk4yuibj	3	10	Philip	Philip	NNP
cord-321868-xk4yuibj	3	11	J.	J.	NNP
cord-321868-xk4yuibj	3	12	title	title	NN
cord-321868-xk4yuibj	3	13	:	:	:
cord-321868-xk4yuibj	3	14	Ribosomal	Ribosomal	NNP
cord-321868-xk4yuibj	3	15	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	3	16	in	in	IN
cord-321868-xk4yuibj	3	17	the	the	DT
cord-321868-xk4yuibj	3	18	yeast	yeast	NN
cord-321868-xk4yuibj	3	19	retrotransposon	retrotransposon	NN
cord-321868-xk4yuibj	3	20	Ty	Ty	NNP
cord-321868-xk4yuibj	3	21	:	:	:
cord-321868-xk4yuibj	4	1	tRNAs	trna	NNS
cord-321868-xk4yuibj	4	2	induce	induce	VBP
cord-321868-xk4yuibj	4	3	slippage	slippage	NN
cord-321868-xk4yuibj	4	4	on	on	IN
cord-321868-xk4yuibj	4	5	a	a	DT
cord-321868-xk4yuibj	4	6	7	7	CD
cord-321868-xk4yuibj	4	7	nucleotide	nucleotide	NN
cord-321868-xk4yuibj	4	8	minimal	minimal	JJ
cord-321868-xk4yuibj	4	9	site	site	NN
cord-321868-xk4yuibj	4	10	date	date	NN
cord-321868-xk4yuibj	4	11	:	:	:
cord-321868-xk4yuibj	4	12	1990	1990	CD
cord-321868-xk4yuibj	4	13	-	-	SYM
cord-321868-xk4yuibj	4	14	07	07	CD
cord-321868-xk4yuibj	4	15	-	-	HYPH
cord-321868-xk4yuibj	4	16	27	27	CD
cord-321868-xk4yuibj	4	17	journal	journal	NN
cord-321868-xk4yuibj	4	18	:	:	:
cord-321868-xk4yuibj	5	1	Cell	cell	NN
cord-321868-xk4yuibj	5	2	DOI	doi	NN
cord-321868-xk4yuibj	5	3	:	:	:
cord-321868-xk4yuibj	5	4	10.1016/0092	10.1016/0092	CD
cord-321868-xk4yuibj	5	5	-	-	HYPH
cord-321868-xk4yuibj	5	6	8674(90)90371-k	8674(90)90371-k	CD
cord-321868-xk4yuibj	5	7	sha	sha	NN
cord-321868-xk4yuibj	5	8	:	:	:
cord-321868-xk4yuibj	6	1	f65bd12c7c03725e764af2781e0142d6ea2a22c9	f65bd12c7c03725e764af2781e0142d6ea2a22c9	NNP
cord-321868-xk4yuibj	6	2	doc_id	doc_id	NNP
cord-321868-xk4yuibj	6	3	:	:	:
cord-321868-xk4yuibj	6	4	321868	321868	CD
cord-321868-xk4yuibj	6	5	cord_uid	cord_uid	NNS
cord-321868-xk4yuibj	6	6	:	:	:
cord-321868-xk4yuibj	7	1	xk4yuibj	xk4yuibj	NNP
cord-321868-xk4yuibj	8	1	Abstract	Abstract	NNP
cord-321868-xk4yuibj	8	2	Ribosomal	Ribosomal	NNP
cord-321868-xk4yuibj	8	3	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	8	4	regulates	regulate	VBZ
cord-321868-xk4yuibj	8	5	expression	expression	NN
cord-321868-xk4yuibj	8	6	of	of	IN
cord-321868-xk4yuibj	8	7	the	the	DT
cord-321868-xk4yuibj	8	8	TYB	TYB	NNP
cord-321868-xk4yuibj	8	9	gene	gene	NN
cord-321868-xk4yuibj	8	10	of	of	IN
cord-321868-xk4yuibj	8	11	yeast	yeast	NN
cord-321868-xk4yuibj	8	12	Ty	ty	NN
cord-321868-xk4yuibj	8	13	retrotransposons	retrotransposon	NNS
cord-321868-xk4yuibj	8	14	.	.	.
cord-321868-xk4yuibj	9	1	We	-PRON-	PRP
cord-321868-xk4yuibj	9	2	previously	previously	RB
cord-321868-xk4yuibj	9	3	demonstrated	demonstrate	VBD
cord-321868-xk4yuibj	9	4	that	that	IN
cord-321868-xk4yuibj	9	5	a	a	DT
cord-321868-xk4yuibj	9	6	14	14	CD
cord-321868-xk4yuibj	9	7	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	9	8	sequence	sequence	NN
cord-321868-xk4yuibj	9	9	conserved	conserve	VBN
cord-321868-xk4yuibj	9	10	between	between	IN
cord-321868-xk4yuibj	9	11	two	two	CD
cord-321868-xk4yuibj	9	12	families	family	NNS
cord-321868-xk4yuibj	9	13	of	of	IN
cord-321868-xk4yuibj	9	14	Ty	Ty	NNP
cord-321868-xk4yuibj	9	15	elements	element	NNS
cord-321868-xk4yuibj	9	16	was	be	VBD
cord-321868-xk4yuibj	9	17	necessary	necessary	JJ
cord-321868-xk4yuibj	9	18	and	and	CC
cord-321868-xk4yuibj	9	19	sufficient	sufficient	JJ
cord-321868-xk4yuibj	9	20	to	to	TO
cord-321868-xk4yuibj	9	21	support	support	VB
cord-321868-xk4yuibj	9	22	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	9	23	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	9	24	.	.	.
cord-321868-xk4yuibj	10	1	This	this	DT
cord-321868-xk4yuibj	10	2	work	work	NN
cord-321868-xk4yuibj	10	3	demonstrates	demonstrate	VBZ
cord-321868-xk4yuibj	10	4	that	that	IN
cord-321868-xk4yuibj	10	5	only	only	RB
cord-321868-xk4yuibj	10	6	7	7	CD
cord-321868-xk4yuibj	10	7	of	of	IN
cord-321868-xk4yuibj	10	8	these	these	DT
cord-321868-xk4yuibj	10	9	14	14	CD
cord-321868-xk4yuibj	10	10	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	10	11	are	be	VBP
cord-321868-xk4yuibj	10	12	needed	need	VBN
cord-321868-xk4yuibj	10	13	for	for	IN
cord-321868-xk4yuibj	10	14	normal	normal	JJ
cord-321868-xk4yuibj	10	15	levels	level	NNS
cord-321868-xk4yuibj	10	16	of	of	IN
cord-321868-xk4yuibj	10	17	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	10	18	.	.	.
cord-321868-xk4yuibj	11	1	Any	any	DT
cord-321868-xk4yuibj	11	2	change	change	NN
cord-321868-xk4yuibj	11	3	to	to	IN
cord-321868-xk4yuibj	11	4	the	the	DT
cord-321868-xk4yuibj	11	5	sequence	sequence	NN
cord-321868-xk4yuibj	11	6	CUU	CUU	NNP
cord-321868-xk4yuibj	11	7	-	-	HYPH
cord-321868-xk4yuibj	11	8	AGG	agg	NN
cord-321868-xk4yuibj	11	9	-	-	HYPH
cord-321868-xk4yuibj	11	10	C	C	NNP
cord-321868-xk4yuibj	11	11	drastically	drastically	RB
cord-321868-xk4yuibj	11	12	reduces	reduce	VBZ
cord-321868-xk4yuibj	11	13	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	11	14	;	;	:
cord-321868-xk4yuibj	11	15	this	this	DT
cord-321868-xk4yuibj	11	16	suggests	suggest	VBZ
cord-321868-xk4yuibj	11	17	that	that	IN
cord-321868-xk4yuibj	11	18	two	two	CD
cord-321868-xk4yuibj	11	19	specific	specific	JJ
cord-321868-xk4yuibj	11	20	tRNAs	trna	NNS
cord-321868-xk4yuibj	11	21	,	,	,
cord-321868-xk4yuibj	11	22	tRNALeu	tRNALeu	NNP
cord-321868-xk4yuibj	11	23	UAG	UAG	NNP
cord-321868-xk4yuibj	11	24	and	and	CC
cord-321868-xk4yuibj	11	25	tRNAArg	tRNAArg	NNP
cord-321868-xk4yuibj	11	26	CCU	CCU	NNP
cord-321868-xk4yuibj	11	27	,	,	,
cord-321868-xk4yuibj	11	28	are	be	VBP
cord-321868-xk4yuibj	11	29	involved	involve	VBN
cord-321868-xk4yuibj	11	30	in	in	IN
cord-321868-xk4yuibj	11	31	the	the	DT
cord-321868-xk4yuibj	11	32	event	event	NN
cord-321868-xk4yuibj	11	33	.	.	.
cord-321868-xk4yuibj	12	1	Our	-PRON-	PRP$
cord-321868-xk4yuibj	12	2	tRNA	trna	NN
cord-321868-xk4yuibj	12	3	overproduction	overproduction	NN
cord-321868-xk4yuibj	12	4	data	datum	NNS
cord-321868-xk4yuibj	12	5	suggest	suggest	VBP
cord-321868-xk4yuibj	12	6	that	that	IN
cord-321868-xk4yuibj	12	7	a	a	DT
cord-321868-xk4yuibj	12	8	leucyl	leucyl	NNP
cord-321868-xk4yuibj	12	9	-	-	HYPH
cord-321868-xk4yuibj	12	10	tRNA	tRNA	NNP
cord-321868-xk4yuibj	12	11	,	,	,
cord-321868-xk4yuibj	12	12	probably	probably	RB
cord-321868-xk4yuibj	12	13	tRNALeu	tRNALeu	NNP
cord-321868-xk4yuibj	12	14	UAG	UAG	NNP
cord-321868-xk4yuibj	12	15	,	,	,
cord-321868-xk4yuibj	12	16	an	an	DT
cord-321868-xk4yuibj	12	17	unusual	unusual	JJ
cord-321868-xk4yuibj	12	18	leucine	leucine	NN
cord-321868-xk4yuibj	12	19	isoacceptor	isoacceptor	NN
cord-321868-xk4yuibj	12	20	that	that	WDT
cord-321868-xk4yuibj	12	21	recognizes	recognize	VBZ
cord-321868-xk4yuibj	12	22	all	all	DT
cord-321868-xk4yuibj	12	23	six	six	CD
cord-321868-xk4yuibj	12	24	leucine	leucine	NN
cord-321868-xk4yuibj	12	25	codons	codon	NNS
cord-321868-xk4yuibj	12	26	,	,	,
cord-321868-xk4yuibj	12	27	slips	slip	VBZ
cord-321868-xk4yuibj	12	28	from	from	IN
cord-321868-xk4yuibj	12	29	CUU	CUU	NNP
cord-321868-xk4yuibj	12	30	-	-	HYPH
cord-321868-xk4yuibj	12	31	Leu	Leu	NNP
cord-321868-xk4yuibj	12	32	onto	onto	IN
cord-321868-xk4yuibj	12	33	UUA	UUA	NNP
cord-321868-xk4yuibj	12	34	-	-	HYPH
cord-321868-xk4yuibj	12	35	Leu	Leu	NNP
cord-321868-xk4yuibj	12	36	(	(	-LRB-
cord-321868-xk4yuibj	12	37	in	in	IN
cord-321868-xk4yuibj	12	38	the	the	DT
cord-321868-xk4yuibj	12	39	+1	+1	HYPH
cord-321868-xk4yuibj	12	40	reading	reading	NN
cord-321868-xk4yuibj	12	41	frame	frame	NN
cord-321868-xk4yuibj	12	42	)	)	-RRB-
cord-321868-xk4yuibj	12	43	during	during	IN
cord-321868-xk4yuibj	12	44	a	a	DT
cord-321868-xk4yuibj	12	45	translational	translational	JJ
cord-321868-xk4yuibj	12	46	pause	pause	NN
cord-321868-xk4yuibj	12	47	at	at	IN
cord-321868-xk4yuibj	12	48	the	the	DT
cord-321868-xk4yuibj	12	49	AGG	agg	NN
cord-321868-xk4yuibj	12	50	-	-	HYPH
cord-321868-xk4yuibj	12	51	Arg	arg	NN
cord-321868-xk4yuibj	12	52	codon	codon	NN
cord-321868-xk4yuibj	12	53	induced	induce	VBN
cord-321868-xk4yuibj	12	54	by	by	IN
cord-321868-xk4yuibj	12	55	the	the	DT
cord-321868-xk4yuibj	12	56	low	low	JJ
cord-321868-xk4yuibj	12	57	availability	availability	NN
cord-321868-xk4yuibj	12	58	of	of	IN
cord-321868-xk4yuibj	12	59	tRNAArg	tRNAArg	NNP
cord-321868-xk4yuibj	12	60	CCU	CCU	NNP
cord-321868-xk4yuibj	12	61	,	,	,
cord-321868-xk4yuibj	12	62	encoded	encode	VBN
cord-321868-xk4yuibj	12	63	by	by	IN
cord-321868-xk4yuibj	12	64	a	a	DT
cord-321868-xk4yuibj	12	65	single	single	JJ
cord-321868-xk4yuibj	12	66	-	-	HYPH
cord-321868-xk4yuibj	12	67	copy	copy	NN
cord-321868-xk4yuibj	12	68	essential	essential	JJ
cord-321868-xk4yuibj	12	69	gene	gene	NN
cord-321868-xk4yuibj	12	70	.	.	.
cord-321868-xk4yuibj	13	1	Frameshifting	Frameshifting	NNP
cord-321868-xk4yuibj	13	2	is	be	VBZ
cord-321868-xk4yuibj	13	3	also	also	RB
cord-321868-xk4yuibj	13	4	directional	directional	JJ
cord-321868-xk4yuibj	13	5	and	and	CC
cord-321868-xk4yuibj	13	6	reading	read	VBG
cord-321868-xk4yuibj	13	7	frame	frame	NN
cord-321868-xk4yuibj	13	8	specific	specific	JJ
cord-321868-xk4yuibj	13	9	.	.	.
cord-321868-xk4yuibj	14	1	Interestingly	interestingly	RB
cord-321868-xk4yuibj	14	2	,	,	,
cord-321868-xk4yuibj	14	3	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	14	4	is	be	VBZ
cord-321868-xk4yuibj	14	5	inhibited	inhibit	VBN
cord-321868-xk4yuibj	14	6	when	when	WRB
cord-321868-xk4yuibj	14	7	the	the	DT
cord-321868-xk4yuibj	14	8	“	"	``
cord-321868-xk4yuibj	14	9	slip	slip	NN
cord-321868-xk4yuibj	14	10	”	"	''
cord-321868-xk4yuibj	14	11	CUU	CUU	NNP
cord-321868-xk4yuibj	14	12	codon	codon	NN
cord-321868-xk4yuibj	14	13	is	be	VBZ
cord-321868-xk4yuibj	14	14	located	locate	VBN
cord-321868-xk4yuibj	14	15	three	three	CD
cord-321868-xk4yuibj	14	16	codons	codon	NNS
cord-321868-xk4yuibj	14	17	downstream	downstream	RB
cord-321868-xk4yuibj	14	18	,	,	,
cord-321868-xk4yuibj	14	19	but	but	CC
cord-321868-xk4yuibj	14	20	not	not	RB
cord-321868-xk4yuibj	14	21	four	four	CD
cord-321868-xk4yuibj	14	22	or	or	CC
cord-321868-xk4yuibj	14	23	more	more	JJR
cord-321868-xk4yuibj	14	24	codons	codon	NNS
cord-321868-xk4yuibj	14	25	downstream	downstream	RB
cord-321868-xk4yuibj	14	26	,	,	,
cord-321868-xk4yuibj	14	27	of	of	IN
cord-321868-xk4yuibj	14	28	the	the	DT
cord-321868-xk4yuibj	14	29	translational	translational	JJ
cord-321868-xk4yuibj	14	30	initiation	initiation	NN
cord-321868-xk4yuibj	14	31	codon	codon	NNP
cord-321868-xk4yuibj	14	32	.	.	.
cord-321868-xk4yuibj	15	1	Establishment	establishment	NN
cord-321868-xk4yuibj	15	2	of	of	IN
cord-321868-xk4yuibj	15	3	the	the	DT
cord-321868-xk4yuibj	15	4	translational	translational	JJ
cord-321868-xk4yuibj	15	5	reading	reading	NN
cord-321868-xk4yuibj	15	6	frame	frame	NN
cord-321868-xk4yuibj	15	7	in	in	IN
cord-321868-xk4yuibj	15	8	eukaryotes	eukaryote	NNS
cord-321868-xk4yuibj	15	9	occurs	occur	VBZ
cord-321868-xk4yuibj	15	10	during	during	IN
cord-321868-xk4yuibj	15	11	initiation	initiation	NN
cord-321868-xk4yuibj	15	12	of	of	IN
cord-321868-xk4yuibj	15	13	protein	protein	NN
cord-321868-xk4yuibj	15	14	synthesis	synthesis	NN
cord-321868-xk4yuibj	15	15	when	when	WRB
cord-321868-xk4yuibj	15	16	the	the	DT
cord-321868-xk4yuibj	15	17	first	first	JJ
cord-321868-xk4yuibj	15	18	AUG	AUG	NNP
cord-321868-xk4yuibj	15	19	codon	codon	NN
cord-321868-xk4yuibj	15	20	in	in	IN
cord-321868-xk4yuibj	15	21	the	the	DT
cord-321868-xk4yuibj	15	22	mRNA	mrna	NN
cord-321868-xk4yuibj	15	23	is	be	VBZ
cord-321868-xk4yuibj	15	24	located	locate	VBN
cord-321868-xk4yuibj	15	25	by	by	IN
cord-321868-xk4yuibj	15	26	a	a	DT
cord-321868-xk4yuibj	15	27	component	component	NN
cord-321868-xk4yuibj	15	28	of	of	IN
cord-321868-xk4yuibj	15	29	the	the	DT
cord-321868-xk4yuibj	15	30	scanning	scanning	NN
cord-321868-xk4yuibj	15	31	40s	40	NNS
cord-321868-xk4yuibj	15	32	initiation	initiation	NN
cord-321868-xk4yuibj	15	33	complex	complex	NN
cord-321868-xk4yuibj	15	34	,	,	,
cord-321868-xk4yuibj	15	35	tRNAy	trnay	CD
cord-321868-xk4yuibj	15	36	*	*	NFP
cord-321868-xk4yuibj	15	37	(	(	-LRB-
cord-321868-xk4yuibj	15	38	Cigan	Cigan	NNP
cord-321868-xk4yuibj	15	39	et	et	FW
cord-321868-xk4yuibj	15	40	al	al	NNP
cord-321868-xk4yuibj	15	41	.	.	NNP
cord-321868-xk4yuibj	15	42	,	,	,
cord-321868-xk4yuibj	15	43	1966	1966	CD
cord-321868-xk4yuibj	15	44	)	)	-RRB-
cord-321868-xk4yuibj	15	45	.	.	.
cord-321868-xk4yuibj	16	1	Following	follow	VBG
cord-321868-xk4yuibj	16	2	60s	60	NNS
cord-321868-xk4yuibj	16	3	ribosome	ribosome	NN
cord-321868-xk4yuibj	16	4	assembly	assembly	NN
cord-321868-xk4yuibj	16	5	,	,	,
cord-321868-xk4yuibj	16	6	translation	translation	NN
cord-321868-xk4yuibj	16	7	continues	continue	VBZ
cord-321868-xk4yuibj	16	8	in	in	IN
cord-321868-xk4yuibj	16	9	3	3	CD
cord-321868-xk4yuibj	16	10	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	16	11	steps	step	NNS
cord-321868-xk4yuibj	16	12	with	with	IN
cord-321868-xk4yuibj	16	13	a	a	DT
cord-321868-xk4yuibj	16	14	very	very	RB
cord-321868-xk4yuibj	16	15	high	high	JJ
cord-321868-xk4yuibj	16	16	degree	degree	NN
cord-321868-xk4yuibj	16	17	of	of	IN
cord-321868-xk4yuibj	16	18	accuracy	accuracy	NN
cord-321868-xk4yuibj	16	19	,	,	,
cord-321868-xk4yuibj	16	20	reflecting	reflect	VBG
cord-321868-xk4yuibj	16	21	the	the	DT
cord-321868-xk4yuibj	16	22	fact	fact	NN
cord-321868-xk4yuibj	16	23	that	that	IN
cord-321868-xk4yuibj	16	24	maintenance	maintenance	NN
cord-321868-xk4yuibj	16	25	of	of	IN
cord-321868-xk4yuibj	16	26	the	the	DT
cord-321868-xk4yuibj	16	27	translational	translational	JJ
cord-321868-xk4yuibj	16	28	reading	reading	NN
cord-321868-xk4yuibj	16	29	frame	frame	NN
cord-321868-xk4yuibj	16	30	is	be	VBZ
cord-321868-xk4yuibj	16	31	essential	essential	JJ
cord-321868-xk4yuibj	16	32	for	for	IN
cord-321868-xk4yuibj	16	33	useful	useful	JJ
cord-321868-xk4yuibj	16	34	gene	gene	NN
cord-321868-xk4yuibj	16	35	expression	expression	NN
cord-321868-xk4yuibj	16	36	.	.	.
cord-321868-xk4yuibj	17	1	Expression	expression	NN
cord-321868-xk4yuibj	17	2	of	of	IN
cord-321868-xk4yuibj	17	3	the	the	DT
cord-321868-xk4yuibj	17	4	NB	NB	NNP
cord-321868-xk4yuibj	17	5	gene	gene	NN
cord-321868-xk4yuibj	17	6	of	of	IN
cord-321868-xk4yuibj	17	7	yeast	yeast	NN
cord-321868-xk4yuibj	18	1	Ty	Ty	NNP
cord-321868-xk4yuibj	18	2	retrotransposons	retrotransposon	NNS
cord-321868-xk4yuibj	18	3	occurs	occur	VBZ
cord-321868-xk4yuibj	18	4	by	by	IN
cord-321868-xk4yuibj	18	5	disruption	disruption	NN
cord-321868-xk4yuibj	18	6	of	of	IN
cord-321868-xk4yuibj	18	7	this	this	DT
cord-321868-xk4yuibj	18	8	highly	highly	RB
cord-321868-xk4yuibj	18	9	accurate	accurate	JJ
cord-321868-xk4yuibj	18	10	translocation	translocation	NN
cord-321868-xk4yuibj	18	11	mechanism	mechanism	NN
cord-321868-xk4yuibj	18	12	at	at	IN
cord-321868-xk4yuibj	18	13	levels	level	NNS
cord-321868-xk4yuibj	18	14	approaching	approach	VBG
cord-321868-xk4yuibj	18	15	50	50	CD
cord-321868-xk4yuibj	18	16	%	%	NN
cord-321868-xk4yuibj	19	1	(	(	-LRB-
cord-321868-xk4yuibj	19	2	Clare	Clare	NNP
cord-321868-xk4yuibj	19	3	et	et	NNP
cord-321868-xk4yuibj	19	4	al	al	NNP
cord-321868-xk4yuibj	19	5	.	.	NNP
cord-321868-xk4yuibj	19	6	,	,	,
cord-321868-xk4yuibj	19	7	1988	1988	CD
cord-321868-xk4yuibj	19	8	;	;	:
cord-321868-xk4yuibj	19	9	Wilson	Wilson	NNP
cord-321868-xk4yuibj	19	10	et	et	NNP
cord-321868-xk4yuibj	19	11	al	al	NNP
cord-321868-xk4yuibj	19	12	.	.	NNP
cord-321868-xk4yuibj	19	13	,	,	,
cord-321868-xk4yuibj	19	14	1986	1986	CD
cord-321868-xk4yuibj	19	15	)	)	-RRB-
cord-321868-xk4yuibj	19	16	.	.	.
cord-321868-xk4yuibj	20	1	How	how	WRB
cord-321868-xk4yuibj	20	2	is	be	VBZ
cord-321868-xk4yuibj	20	3	this	this	DT
cord-321868-xk4yuibj	20	4	level	level	NN
cord-321868-xk4yuibj	20	5	of	of	IN
cord-321868-xk4yuibj	20	6	"	"	``
cord-321868-xk4yuibj	20	7	inaccuracy	inaccuracy	NN
cord-321868-xk4yuibj	20	8	"	"	''
cord-321868-xk4yuibj	20	9	achieved	achieve	VBN
cord-321868-xk4yuibj	20	10	?	?	.
cord-321868-xk4yuibj	21	1	The	the	DT
cord-321868-xk4yuibj	21	2	Tyl	Tyl	NNP
cord-321868-xk4yuibj	21	3	and	and	CC
cord-321868-xk4yuibj	21	4	Ty2	ty2	CD
cord-321868-xk4yuibj	21	5	elements	element	NNS
cord-321868-xk4yuibj	21	6	are	be	VBP
cord-321868-xk4yuibj	21	7	members	member	NNS
cord-321868-xk4yuibj	21	8	of	of	IN
cord-321868-xk4yuibj	21	9	a	a	DT
cord-321868-xk4yuibj	21	10	family	family	NN
cord-321868-xk4yuibj	21	11	of	of	IN
cord-321868-xk4yuibj	21	12	retrotransposons	retrotransposon	NNS
cord-321868-xk4yuibj	21	13	found	find	VBN
cord-321868-xk4yuibj	21	14	dispersed	disperse	VBN
cord-321868-xk4yuibj	21	15	throughout	throughout	IN
cord-321868-xk4yuibj	21	16	the	the	DT
cord-321868-xk4yuibj	21	17	genome	genome	NN
cord-321868-xk4yuibj	21	18	of	of	IN
cord-321868-xk4yuibj	21	19	the	the	DT
cord-321868-xk4yuibj	21	20	yeast	yeast	NN
cord-321868-xk4yuibj	21	21	Saccharomyces	Saccharomyces	NNP
cord-321868-xk4yuibj	21	22	cerevisiae	cerevisiae	NNS
cord-321868-xk4yuibj	21	23	(	(	-LRB-
cord-321868-xk4yuibj	21	24	Cameron	Cameron	NNP
cord-321868-xk4yuibj	21	25	et	et	NNP
cord-321868-xk4yuibj	21	26	al	al	NNP
cord-321868-xk4yuibj	21	27	.	.	NNP
cord-321868-xk4yuibj	21	28	,	,	,
cord-321868-xk4yuibj	21	29	1979	1979	CD
cord-321868-xk4yuibj	21	30	)	)	-RRB-
cord-321868-xk4yuibj	21	31	.	.	.
cord-321868-xk4yuibj	22	1	They	-PRON-	PRP
cord-321868-xk4yuibj	22	2	consist	consist	VBP
cord-321868-xk4yuibj	22	3	of	of	IN
cord-321868-xk4yuibj	22	4	0.33	0.33	CD
cord-321868-xk4yuibj	22	5	kb	kb	NNP
cord-321868-xk4yuibj	22	6	terminal	terminal	NNP
cord-321868-xk4yuibj	22	7	direct	direct	NNP
cord-321868-xk4yuibj	22	8	repeats	repeat	NNS
cord-321868-xk4yuibj	22	9	called	call	VBN
cord-321868-xk4yuibj	22	10	"	"	``
cord-321868-xk4yuibj	22	11	delta	delta	NN
cord-321868-xk4yuibj	22	12	"	"	''
cord-321868-xk4yuibj	22	13	(	(	-LRB-
cord-321868-xk4yuibj	22	14	6	6	CD
cord-321868-xk4yuibj	22	15	)	)	-RRB-
cord-321868-xk4yuibj	22	16	flanking	flank	VBG
cord-321868-xk4yuibj	22	17	a	a	DT
cord-321868-xk4yuibj	22	18	5.3	5.3	CD
cord-321868-xk4yuibj	22	19	kb	kb	NNP
cord-321868-xk4yuibj	22	20	internal	internal	JJ
cord-321868-xk4yuibj	22	21	region	region	NN
cord-321868-xk4yuibj	22	22	termed	term	VBD
cord-321868-xk4yuibj	22	23	"	"	``
cord-321868-xk4yuibj	22	24	epsilon	epsilon	NN
cord-321868-xk4yuibj	22	25	"	"	''
cord-321868-xk4yuibj	22	26	(	(	-LRB-
cord-321868-xk4yuibj	22	27	E	e	NN
cord-321868-xk4yuibj	22	28	)	)	-RRB-
cord-321868-xk4yuibj	22	29	.	.	.
cord-321868-xk4yuibj	23	1	Along	along	IN
cord-321868-xk4yuibj	23	2	with	with	IN
cord-321868-xk4yuibj	23	3	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	23	4	of	of	IN
cord-321868-xk4yuibj	23	5	higher	high	JJR
cord-321868-xk4yuibj	23	6	eukaryotes	eukaryote	NNS
cord-321868-xk4yuibj	23	7	(	(	-LRB-
cord-321868-xk4yuibj	23	8	reviewed	review	VBN
cord-321868-xk4yuibj	23	9	in	in	IN
cord-321868-xk4yuibj	23	10	Varmus	Varmus	NNP
cord-321868-xk4yuibj	23	11	,	,	,
cord-321868-xk4yuibj	23	12	1983	1983	CD
cord-321868-xk4yuibj	23	13	)	)	-RRB-
cord-321868-xk4yuibj	23	14	the	the	DT
cord-321868-xk4yuibj	23	15	copia	copia	NN
cord-321868-xk4yuibj	23	16	-	-	HYPH
cord-321868-xk4yuibj	23	17	like	like	JJ
cord-321868-xk4yuibj	23	18	elements	element	NNS
cord-321868-xk4yuibj	23	19	of	of	IN
cord-321868-xk4yuibj	23	20	Drosophila	drosophila	JJ
cord-321868-xk4yuibj	23	21	species	specie	NNS
cord-321868-xk4yuibj	24	1	(	(	-LRB-
cord-321868-xk4yuibj	24	2	Emori	Emori	NNP
cord-321868-xk4yuibj	24	3	et	et	NNP
cord-321868-xk4yuibj	24	4	al	al	NNP
cord-321868-xk4yuibj	24	5	.	.	NNP
cord-321868-xk4yuibj	24	6	,	,	,
cord-321868-xk4yuibj	24	7	1985	1985	CD
cord-321868-xk4yuibj	24	8	;	;	:
cord-321868-xk4yuibj	24	9	Mount	Mount	NNP
cord-321868-xk4yuibj	24	10	and	and	CC
cord-321868-xk4yuibj	24	11	Rubin	Rubin	NNP
cord-321868-xk4yuibj	24	12	,	,	,
cord-321868-xk4yuibj	24	13	1985	1985	CD
cord-321868-xk4yuibj	24	14	)	)	-RRB-
cord-321868-xk4yuibj	24	15	,	,	,
cord-321868-xk4yuibj	24	16	and	and	CC
cord-321868-xk4yuibj	24	17	LlMd	LlMd	NNP
cord-321868-xk4yuibj	24	18	of	of	IN
cord-321868-xk4yuibj	24	19	mice	mouse	NNS
cord-321868-xk4yuibj	25	1	(	(	-LRB-
cord-321868-xk4yuibj	25	2	Loeb	Loeb	NNP
cord-321868-xk4yuibj	25	3	et	et	NNP
cord-321868-xk4yuibj	25	4	al	al	NNP
cord-321868-xk4yuibj	25	5	.	.	NNP
cord-321868-xk4yuibj	25	6	,	,	,
cord-321868-xk4yuibj	25	7	1986	1986	CD
cord-321868-xk4yuibj	25	8	)	)	-RRB-
cord-321868-xk4yuibj	25	9	,	,	,
cord-321868-xk4yuibj	25	10	Ty	Ty	NNP
cord-321868-xk4yuibj	25	11	elements	element	NNS
cord-321868-xk4yuibj	25	12	are	be	VBP
cord-321868-xk4yuibj	25	13	members	member	NNS
cord-321868-xk4yuibj	25	14	of	of	IN
cord-321868-xk4yuibj	25	15	a	a	DT
cord-321868-xk4yuibj	25	16	family	family	NN
cord-321868-xk4yuibj	25	17	of	of	IN
cord-321868-xk4yuibj	25	18	elements	element	NNS
cord-321868-xk4yuibj	25	19	that	that	WDT
cord-321868-xk4yuibj	25	20	replicate	replicate	VBP
cord-321868-xk4yuibj	25	21	via	via	IN
cord-321868-xk4yuibj	25	22	an	an	DT
cord-321868-xk4yuibj	25	23	RNA	RNA	NNP
cord-321868-xk4yuibj	25	24	intermediate	intermediate	NN
cord-321868-xk4yuibj	25	25	.	.	.
cord-321868-xk4yuibj	26	1	Encoded	encode	VBN
cord-321868-xk4yuibj	26	2	by	by	IN
cord-321868-xk4yuibj	26	3	Ty	Ty	NNP
cord-321868-xk4yuibj	26	4	elements	element	NNS
cord-321868-xk4yuibj	26	5	are	be	VBP
cord-321868-xk4yuibj	26	6	two	two	CD
cord-321868-xk4yuibj	26	7	genes	gene	NNS
cord-321868-xk4yuibj	26	8	,	,	,
cord-321868-xk4yuibj	26	9	NA	NA	NNP
cord-321868-xk4yuibj	26	10	and	and	CC
cord-321868-xk4yuibj	26	11	NB	NB	NNP
cord-321868-xk4yuibj	26	12	.	.	.
cord-321868-xk4yuibj	27	1	Ty	ty	JJ
cord-321868-xk4yuibj	27	2	elements	element	NNS
cord-321868-xk4yuibj	27	3	replicate	replicate	VBP
cord-321868-xk4yuibj	27	4	by	by	IN
cord-321868-xk4yuibj	27	5	a	a	DT
cord-321868-xk4yuibj	27	6	retroviral	retroviral	NN
cord-321868-xk4yuibj	27	7	-	-	HYPH
cord-321868-xk4yuibj	27	8	like	like	JJ
cord-321868-xk4yuibj	27	9	mechanism	mechanism	NN
cord-321868-xk4yuibj	27	10	(	(	-LRB-
cord-321868-xk4yuibj	27	11	Boeke	Boeke	NNP
cord-321868-xk4yuibj	27	12	et	et	FW
cord-321868-xk4yuibj	27	13	al	al	NNP
cord-321868-xk4yuibj	27	14	.	.	NNP
cord-321868-xk4yuibj	27	15	,	,	,
cord-321868-xk4yuibj	27	16	1985	1985	CD
cord-321868-xk4yuibj	27	17	)	)	-RRB-
cord-321868-xk4yuibj	27	18	within	within	IN
cord-321868-xk4yuibj	27	19	a	a	DT
cord-321868-xk4yuibj	27	20	virus	virus	NN
cord-321868-xk4yuibj	27	21	-	-	HYPH
cord-321868-xk4yuibj	27	22	like	like	JJ
cord-321868-xk4yuibj	27	23	particle	particle	NN
cord-321868-xk4yuibj	27	24	encoded	encode	VBN
cord-321868-xk4yuibj	27	25	by	by	IN
cord-321868-xk4yuibj	27	26	the	the	DT
cord-321868-xk4yuibj	27	27	products	product	NNS
cord-321868-xk4yuibj	27	28	of	of	IN
cord-321868-xk4yuibj	27	29	the	the	DT
cord-321868-xk4yuibj	27	30	NA	NA	NNP
cord-321868-xk4yuibj	27	31	gene	gene	NN
cord-321868-xk4yuibj	27	32	,	,	,
cord-321868-xk4yuibj	27	33	the	the	DT
cord-321868-xk4yuibj	27	34	analog	analog	NN
cord-321868-xk4yuibj	27	35	of	of	IN
cord-321868-xk4yuibj	27	36	the	the	DT
cord-321868-xk4yuibj	27	37	retroviral	retroviral	JJ
cord-321868-xk4yuibj	27	38	gag	gag	NN
cord-321868-xk4yuibj	27	39	gene	gene	NN
cord-321868-xk4yuibj	27	40	(	(	-LRB-
cord-321868-xk4yuibj	27	41	Adams	Adams	NNP
cord-321868-xk4yuibj	27	42	et	et	NNP
cord-321868-xk4yuibj	27	43	al	al	NNP
cord-321868-xk4yuibj	27	44	.	.	NNP
cord-321868-xk4yuibj	27	45	,	,	,
cord-321868-xk4yuibj	27	46	1987	1987	CD
cord-321868-xk4yuibj	27	47	;	;	:
cord-321868-xk4yuibj	27	48	Garfinkel	Garfinkel	NNP
cord-321868-xk4yuibj	27	49	et	et	NNP
cord-321868-xk4yuibj	27	50	al	al	NNP
cord-321868-xk4yuibj	27	51	.	.	NNP
cord-321868-xk4yuibj	27	52	,	,	,
cord-321868-xk4yuibj	27	53	1965	1965	CD
cord-321868-xk4yuibj	27	54	;	;	:
cord-321868-xk4yuibj	27	55	Mellor	Mellor	NNP
cord-321868-xk4yuibj	27	56	et	et	NNP
cord-321868-xk4yuibj	27	57	al	al	NNP
cord-321868-xk4yuibj	27	58	.	.	NNP
cord-321868-xk4yuibj	27	59	,	,	,
cord-321868-xk4yuibj	27	60	1985b	1985b	CD
cord-321868-xk4yuibj	27	61	)	)	-RRB-
cord-321868-xk4yuibj	27	62	.	.	.
cord-321868-xk4yuibj	28	1	The	the	DT
cord-321868-xk4yuibj	28	2	NB	NB	NNP
cord-321868-xk4yuibj	28	3	gene	gene	NN
cord-321868-xk4yuibj	28	4	includes	include	VBZ
cord-321868-xk4yuibj	28	5	sequence	sequence	NN
cord-321868-xk4yuibj	28	6	homologies	homology	NNS
cord-321868-xk4yuibj	28	7	to	to	IN
cord-321868-xk4yuibj	28	8	retroviral	retroviral	JJ
cord-321868-xk4yuibj	28	9	pal	pal	NN
cord-321868-xk4yuibj	28	10	genes	gene	NNS
cord-321868-xk4yuibj	28	11	,	,	,
cord-321868-xk4yuibj	28	12	which	which	WDT
cord-321868-xk4yuibj	28	13	encode	encode	VBP
cord-321868-xk4yuibj	28	14	the	the	DT
cord-321868-xk4yuibj	28	15	reverse	reverse	JJ
cord-321868-xk4yuibj	28	16	transcriptase	transcriptase	NN
cord-321868-xk4yuibj	28	17	,	,	,
cord-321868-xk4yuibj	28	18	integrase	integrase	NN
cord-321868-xk4yuibj	28	19	,	,	,
cord-321868-xk4yuibj	28	20	and	and	CC
cord-321868-xk4yuibj	28	21	protease	protease	NN
cord-321868-xk4yuibj	28	22	proteins	protein	NNS
cord-321868-xk4yuibj	28	23	.	.	.
cord-321868-xk4yuibj	29	1	As	as	IN
cord-321868-xk4yuibj	29	2	with	with	IN
cord-321868-xk4yuibj	29	3	many	many	JJ
cord-321868-xk4yuibj	29	4	avian	avian	JJ
cord-321868-xk4yuibj	29	5	and	and	CC
cord-321868-xk4yuibj	29	6	mammalian	mammalian	JJ
cord-321868-xk4yuibj	29	7	retroviral	retroviral	NN
cord-321868-xk4yuibj	29	8	pal	pal	NN
cord-321868-xk4yuibj	29	9	genes	gene	NNS
cord-321868-xk4yuibj	29	10	,	,	,
cord-321868-xk4yuibj	29	11	expression	expression	NN
cord-321868-xk4yuibj	29	12	of	of	IN
cord-321868-xk4yuibj	29	13	NB	NB	NNP
cord-321868-xk4yuibj	29	14	requires	require	VBZ
cord-321868-xk4yuibj	29	15	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	29	16	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	29	17	(	(	-LRB-
cord-321868-xk4yuibj	29	18	Clare	Clare	NNP
cord-321868-xk4yuibj	29	19	et	et	NNP
cord-321868-xk4yuibj	29	20	al	al	NNP
cord-321868-xk4yuibj	29	21	.	.	NNP
cord-321868-xk4yuibj	29	22	,	,	,
cord-321868-xk4yuibj	29	23	1988	1988	CD
cord-321868-xk4yuibj	29	24	)	)	-RRB-
cord-321868-xk4yuibj	29	25	.	.	.
cord-321868-xk4yuibj	30	1	TYB	TYB	NNP
cord-321868-xk4yuibj	30	2	,	,	,
cord-321868-xk4yuibj	30	3	like	like	IN
cord-321868-xk4yuibj	30	4	pal	pal	NN
cord-321868-xk4yuibj	30	5	,	,	,
cord-321868-xk4yuibj	30	6	is	be	VBZ
cord-321868-xk4yuibj	30	7	expressed	express	VBN
cord-321868-xk4yuibj	30	8	as	as	IN
cord-321868-xk4yuibj	30	9	a	a	DT
cord-321868-xk4yuibj	30	10	protein	protein	NN
cord-321868-xk4yuibj	30	11	fusion	fusion	NN
cord-321868-xk4yuibj	30	12	to	to	IN
cord-321868-xk4yuibj	30	13	the	the	DT
cord-321868-xk4yuibj	30	14	product	product	NN
cord-321868-xk4yuibj	30	15	of	of	IN
cord-321868-xk4yuibj	30	16	the	the	DT
cord-321868-xk4yuibj	30	17	upstream	upstream	JJ
cord-321868-xk4yuibj	30	18	gene	gene	NN
cord-321868-xk4yuibj	30	19	,	,	,
cord-321868-xk4yuibj	30	20	NA	NA	NNP
cord-321868-xk4yuibj	30	21	(	(	-LRB-
cord-321868-xk4yuibj	30	22	Clare	Clare	NNP
cord-321868-xk4yuibj	30	23	and	and	CC
cord-321868-xk4yuibj	30	24	Farabaugh	Farabaugh	NNP
cord-321868-xk4yuibj	30	25	,	,	,
cord-321868-xk4yuibj	30	26	1985	1985	CD
cord-321868-xk4yuibj	30	27	;	;	:
cord-321868-xk4yuibj	30	28	Mellor	Mellor	NNP
cord-321868-xk4yuibj	30	29	et	et	NNP
cord-321868-xk4yuibj	30	30	al	al	NNP
cord-321868-xk4yuibj	30	31	.	.	NNP
cord-321868-xk4yuibj	30	32	,	,	,
cord-321868-xk4yuibj	30	33	1985a	1985a	CD
cord-321868-xk4yuibj	30	34	)	)	-RRB-
cord-321868-xk4yuibj	30	35	.	.	.
cord-321868-xk4yuibj	31	1	While	while	IN
cord-321868-xk4yuibj	31	2	retroviral	retroviral	JJ
cord-321868-xk4yuibj	31	3	frameshift	frameshift	NN
cord-321868-xk4yuibj	31	4	events	event	NNS
cord-321868-xk4yuibj	31	5	occur	occur	VBP
cord-321868-xk4yuibj	31	6	in	in	IN
cord-321868-xk4yuibj	31	7	the	the	DT
cord-321868-xk4yuibj	31	8	-1	-1	JJ
cord-321868-xk4yuibj	31	9	direction	direction	NN
cord-321868-xk4yuibj	31	10	in	in	IN
cord-321868-xk4yuibj	31	11	a	a	DT
cord-321868-xk4yuibj	31	12	region	region	NN
cord-321868-xk4yuibj	31	13	of	of	IN
cord-321868-xk4yuibj	31	14	overlap	overlap	NN
cord-321868-xk4yuibj	31	15	between	between	IN
cord-321868-xk4yuibj	31	16	the	the	DT
cord-321868-xk4yuibj	31	17	gag	gag	NN
cord-321868-xk4yuibj	31	18	,	,	,
cord-321868-xk4yuibj	31	19	pal	pal	NN
cord-321868-xk4yuibj	31	20	and	and	CC
cord-321868-xk4yuibj	31	21	sometimes	sometimes	RB
cord-321868-xk4yuibj	31	22	pro	pro	JJ
cord-321868-xk4yuibj	31	23	genes	gene	NNS
cord-321868-xk4yuibj	31	24	(	(	-LRB-
cord-321868-xk4yuibj	32	1	Jacks	Jacks	NNP
cord-321868-xk4yuibj	32	2	et	et	NNP
cord-321868-xk4yuibj	32	3	al	al	NNP
cord-321868-xk4yuibj	32	4	.	.	.
cord-321868-xk4yuibj	33	1	,	,	,
cord-321868-xk4yuibj	33	2	1987	1987	CD
cord-321868-xk4yuibj	33	3	(	(	-LRB-
cord-321868-xk4yuibj	33	4	Jacks	Jacks	NNP
cord-321868-xk4yuibj	33	5	et	et	NNP
cord-321868-xk4yuibj	33	6	al	al	NNP
cord-321868-xk4yuibj	33	7	.	.	.
cord-321868-xk4yuibj	34	1	,	,	,
cord-321868-xk4yuibj	34	2	,	,	,
cord-321868-xk4yuibj	34	3	1988b	1988b	CD
cord-321868-xk4yuibj	34	4	Jacks	Jacks	NNPS
cord-321868-xk4yuibj	34	5	and	and	CC
cord-321868-xk4yuibj	34	6	Varmus	Varmus	NNP
cord-321868-xk4yuibj	34	7	,	,	,
cord-321868-xk4yuibj	34	8	1985	1985	CD
cord-321868-xk4yuibj	34	9	;	;	:
cord-321868-xk4yuibj	35	1	Moore	Moore	NNP
cord-321868-xk4yuibj	35	2	et	et	NNP
cord-321868-xk4yuibj	35	3	al	al	NNP
cord-321868-xk4yuibj	35	4	.	.	.
cord-321868-xk4yuibj	36	1	,	,	,
cord-321868-xk4yuibj	36	2	1987	1987	CD
cord-321868-xk4yuibj	36	3	;	;	:
cord-321868-xk4yuibj	36	4	Wilson	Wilson	NNP
cord-321868-xk4yuibj	36	5	et	et	NNP
cord-321868-xk4yuibj	36	6	al	al	NNP
cord-321868-xk4yuibj	36	7	.	.	NNP
cord-321868-xk4yuibj	36	8	,	,	,
cord-321868-xk4yuibj	36	9	1988	1988	CD
cord-321868-xk4yuibj	36	10	)	)	-RRB-
cord-321868-xk4yuibj	36	11	,	,	,
cord-321868-xk4yuibj	36	12	Ty	ty	NN
cord-321868-xk4yuibj	36	13	frameshift	frameshift	NN
cord-321868-xk4yuibj	36	14	events	event	NNS
cord-321868-xk4yuibj	36	15	occur	occur	VBP
cord-321868-xk4yuibj	36	16	in	in	IN
cord-321868-xk4yuibj	36	17	the	the	DT
cord-321868-xk4yuibj	36	18	+	+	CC
cord-321868-xk4yuibj	36	19	l	l	NN
cord-321868-xk4yuibj	36	20	direction	direction	NN
cord-321868-xk4yuibj	36	21	in	in	IN
cord-321868-xk4yuibj	36	22	the	the	DT
cord-321868-xk4yuibj	36	23	38	38	CD
cord-321868-xk4yuibj	36	24	-	-	SYM
cord-321868-xk4yuibj	36	25	44	44	CD
cord-321868-xk4yuibj	36	26	bp	bp	NNP
cord-321868-xk4yuibj	36	27	overlap	overlap	NN
cord-321868-xk4yuibj	36	28	between	between	IN
cord-321868-xk4yuibj	36	29	NA	NA	NNP
cord-321868-xk4yuibj	36	30	and	and	CC
cord-321868-xk4yuibj	36	31	NB	NB	NNP
cord-321868-xk4yuibj	36	32	.	.	.
cord-321868-xk4yuibj	37	1	In	in	IN
cord-321868-xk4yuibj	37	2	fact	fact	NN
cord-321868-xk4yuibj	37	3	,	,	,
cord-321868-xk4yuibj	37	4	we	-PRON-	PRP
cord-321868-xk4yuibj	37	5	recently	recently	RB
cord-321868-xk4yuibj	37	6	showed	show	VBD
cord-321868-xk4yuibj	37	7	that	that	IN
cord-321868-xk4yuibj	37	8	a	a	DT
cord-321868-xk4yuibj	37	9	14	14	CD
cord-321868-xk4yuibj	37	10	bp	bp	NNP
cord-321868-xk4yuibj	37	11	region	region	NN
cord-321868-xk4yuibj	37	12	of	of	IN
cord-321868-xk4yuibj	37	13	this	this	DT
cord-321868-xk4yuibj	37	14	overlap	overlap	NN
cord-321868-xk4yuibj	37	15	is	be	VBZ
cord-321868-xk4yuibj	37	16	necessary	necessary	JJ
cord-321868-xk4yuibj	37	17	and	and	CC
cord-321868-xk4yuibj	37	18	sufficient	sufficient	JJ
cord-321868-xk4yuibj	37	19	to	to	TO
cord-321868-xk4yuibj	37	20	promote	promote	VB
cord-321868-xk4yuibj	37	21	normal	normal	JJ
cord-321868-xk4yuibj	37	22	levels	level	NNS
cord-321868-xk4yuibj	37	23	of	of	IN
cord-321868-xk4yuibj	37	24	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	37	25	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	38	1	(	(	-LRB-
cord-321868-xk4yuibj	38	2	Clare	Clare	NNP
cord-321868-xk4yuibj	38	3	et	et	NNP
cord-321868-xk4yuibj	38	4	al	al	NNP
cord-321868-xk4yuibj	38	5	.	.	NNP
cord-321868-xk4yuibj	38	6	,	,	,
cord-321868-xk4yuibj	38	7	1988	1988	CD
cord-321868-xk4yuibj	38	8	)	)	-RRB-
cord-321868-xk4yuibj	38	9	.	.	.
cord-321868-xk4yuibj	39	1	In	in	IN
cord-321868-xk4yuibj	39	2	Rous	rous	JJ
cord-321868-xk4yuibj	39	3	sarcoma	sarcoma	NN
cord-321868-xk4yuibj	39	4	virus	virus	NN
cord-321868-xk4yuibj	39	5	(	(	-LRB-
cord-321868-xk4yuibj	39	6	RSV	RSV	NNP
cord-321868-xk4yuibj	39	7	)	)	-RRB-
cord-321868-xk4yuibj	39	8	,	,	,
cord-321868-xk4yuibj	39	9	mouse	mouse	NN
cord-321868-xk4yuibj	39	10	mammary	mammary	JJ
cord-321868-xk4yuibj	39	11	tumor	tumor	NN
cord-321868-xk4yuibj	39	12	virus	virus	NN
cord-321868-xk4yuibj	39	13	(	(	-LRB-
cord-321868-xk4yuibj	39	14	MMTV	MMTV	NNP
cord-321868-xk4yuibj	39	15	)	)	-RRB-
cord-321868-xk4yuibj	39	16	,	,	,
cord-321868-xk4yuibj	39	17	and	and	CC
cord-321868-xk4yuibj	39	18	the	the	DT
cord-321868-xk4yuibj	39	19	avian	avian	JJ
cord-321868-xk4yuibj	39	20	coronavirus	coronavirus	NN
cord-321868-xk4yuibj	39	21	infectious	infectious	JJ
cord-321868-xk4yuibj	39	22	bronchitis	bronchitis	NN
cord-321868-xk4yuibj	39	23	virus	virus	NN
cord-321868-xk4yuibj	39	24	(	(	-LRB-
cord-321868-xk4yuibj	39	25	IBV	IBV	NNP
cord-321868-xk4yuibj	39	26	)	)	-RRB-
cord-321868-xk4yuibj	39	27	,	,	,
cord-321868-xk4yuibj	39	28	RNA	RNA	NNP
cord-321868-xk4yuibj	39	29	secondary	secondary	JJ
cord-321868-xk4yuibj	39	30	structure	structure	NN
cord-321868-xk4yuibj	39	31	in	in	IN
cord-321868-xk4yuibj	39	32	the	the	DT
cord-321868-xk4yuibj	39	33	form	form	NN
cord-321868-xk4yuibj	39	34	of	of	IN
cord-321868-xk4yuibj	39	35	a	a	DT
cord-321868-xk4yuibj	39	36	pseudoknot	pseudoknot	NN
cord-321868-xk4yuibj	39	37	plays	play	VBZ
cord-321868-xk4yuibj	39	38	a	a	DT
cord-321868-xk4yuibj	39	39	critical	critical	JJ
cord-321868-xk4yuibj	39	40	role	role	NN
cord-321868-xk4yuibj	39	41	in	in	IN
cord-321868-xk4yuibj	39	42	the	the	DT
cord-321868-xk4yuibj	39	43	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	39	44	frameshift	frameshift	NN
cord-321868-xk4yuibj	39	45	event	event	NN
cord-321868-xk4yuibj	39	46	,	,	,
cord-321868-xk4yuibj	39	47	presumably	presumably	RB
cord-321868-xk4yuibj	39	48	by	by	IN
cord-321868-xk4yuibj	39	49	causing	cause	VBG
cord-321868-xk4yuibj	39	50	the	the	DT
cord-321868-xk4yuibj	39	51	ribosome	ribosome	NN
cord-321868-xk4yuibj	39	52	to	to	TO
cord-321868-xk4yuibj	39	53	stall	stall	VB
cord-321868-xk4yuibj	39	54	at	at	IN
cord-321868-xk4yuibj	39	55	the	the	DT
cord-321868-xk4yuibj	39	56	site	site	NN
cord-321868-xk4yuibj	39	57	of	of	IN
cord-321868-xk4yuibj	39	58	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	40	1	(	(	-LRB-
cord-321868-xk4yuibj	40	2	Brierley	Brierley	NNP
cord-321868-xk4yuibj	40	3	et	et	NNP
cord-321868-xk4yuibj	40	4	al	al	NNP
cord-321868-xk4yuibj	40	5	.	.	.
cord-321868-xk4yuibj	41	1	,	,	,
cord-321868-xk4yuibj	41	2	1989	1989	CD
cord-321868-xk4yuibj	41	3	;	;	:
cord-321868-xk4yuibj	41	4	Jacks	Jacks	NNP
cord-321868-xk4yuibj	41	5	et	et	NNP
cord-321868-xk4yuibj	41	6	al	al	NNP
cord-321868-xk4yuibj	41	7	.	.	NNP
cord-321868-xk4yuibj	41	8	,	,	,
cord-321868-xk4yuibj	41	9	1987	1987	CD
cord-321868-xk4yuibj	42	1	Jacks	Jacks	NNP
cord-321868-xk4yuibj	42	2	et	et	NNP
cord-321868-xk4yuibj	42	3	al	al	NNP
cord-321868-xk4yuibj	42	4	.	.	.
cord-321868-xk4yuibj	43	1	,	,	,
cord-321868-xk4yuibj	43	2	,	,	,
cord-321868-xk4yuibj	43	3	1988a	1988a	CD
cord-321868-xk4yuibj	43	4	Moore	Moore	NNP
cord-321868-xk4yuibj	43	5	et	et	NNP
cord-321868-xk4yuibj	43	6	al	al	NNP
cord-321868-xk4yuibj	43	7	.	.	NNP
cord-321868-xk4yuibj	43	8	,	,	,
cord-321868-xk4yuibj	43	9	1987	1987	CD
cord-321868-xk4yuibj	43	10	)	)	-RRB-
cord-321868-xk4yuibj	43	11	.	.	.
cord-321868-xk4yuibj	44	1	The	the	DT
cord-321868-xk4yuibj	44	2	region	region	NN
cord-321868-xk4yuibj	44	3	of	of	IN
cord-321868-xk4yuibj	44	4	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	44	5	in	in	IN
cord-321868-xk4yuibj	44	6	Ty	Ty	NNP
cord-321868-xk4yuibj	44	7	elements	element	NNS
cord-321868-xk4yuibj	44	8	contains	contain	VBZ
cord-321868-xk4yuibj	44	9	no	no	DT
cord-321868-xk4yuibj	44	10	obvious	obvious	JJ
cord-321868-xk4yuibj	44	11	secondary	secondary	JJ
cord-321868-xk4yuibj	44	12	structure	structure	NN
cord-321868-xk4yuibj	44	13	.	.	.
cord-321868-xk4yuibj	45	1	In	in	IN
cord-321868-xk4yuibj	45	2	addition	addition	NN
cord-321868-xk4yuibj	45	3	,	,	,
cord-321868-xk4yuibj	45	4	Ty	Ty	NNP
cord-321868-xk4yuibj	45	5	elements	element	NNS
cord-321868-xk4yuibj	45	6	lack	lack	VBP
cord-321868-xk4yuibj	45	7	the	the	DT
cord-321868-xk4yuibj	45	8	characteristic	characteristic	JJ
cord-321868-xk4yuibj	45	9	homopolymeric	homopolymeric	NN
cord-321868-xk4yuibj	45	10	run	run	NN
cord-321868-xk4yuibj	45	11	of	of	IN
cord-321868-xk4yuibj	45	12	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	45	13	(	(	-LRB-
cord-321868-xk4yuibj	45	14	"	"	``
cord-321868-xk4yuibj	45	15	slippery	slippery	JJ
cord-321868-xk4yuibj	45	16	"	"	''
cord-321868-xk4yuibj	45	17	sequences	sequence	NNS
cord-321868-xk4yuibj	45	18	)	)	-RRB-
cord-321868-xk4yuibj	45	19	at	at	IN
cord-321868-xk4yuibj	45	20	the	the	DT
cord-321868-xk4yuibj	45	21	site	site	NN
cord-321868-xk4yuibj	45	22	of	of	IN
cord-321868-xk4yuibj	45	23	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	45	24	that	that	WDT
cord-321868-xk4yuibj	45	25	characterizes	characterize	VBZ
cord-321868-xk4yuibj	45	26	frameshift	frameshift	NN
cord-321868-xk4yuibj	45	27	sites	site	NNS
cord-321868-xk4yuibj	45	28	of	of	IN
cord-321868-xk4yuibj	45	29	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	45	30	and	and	CC
cord-321868-xk4yuibj	45	31	coronaviruses	coronaviruse	NNS
cord-321868-xk4yuibj	46	1	(	(	-LRB-
cord-321868-xk4yuibj	46	2	Brierley	Brierley	NNP
cord-321868-xk4yuibj	46	3	et	et	NNP
cord-321868-xk4yuibj	46	4	al	al	NNP
cord-321868-xk4yuibj	46	5	.	.	.
cord-321868-xk4yuibj	47	1	,	,	,
cord-321868-xk4yuibj	47	2	1989	1989	CD
cord-321868-xk4yuibj	47	3	;	;	:
cord-321868-xk4yuibj	47	4	Jacks	Jacks	NNP
cord-321868-xk4yuibj	47	5	et	et	NNP
cord-321868-xk4yuibj	47	6	al	al	NNP
cord-321868-xk4yuibj	47	7	.	.	NNP
cord-321868-xk4yuibj	47	8	,	,	,
cord-321868-xk4yuibj	47	9	1988a	1988a	CD
cord-321868-xk4yuibj	47	10	)	)	-RRB-
cord-321868-xk4yuibj	47	11	.	.	.
cord-321868-xk4yuibj	48	1	In	in	IN
cord-321868-xk4yuibj	48	2	these	these	DT
cord-321868-xk4yuibj	48	3	systems	system	NNS
cord-321868-xk4yuibj	48	4	,	,	,
cord-321868-xk4yuibj	48	5	a	a	DT
cord-321868-xk4yuibj	48	6	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	48	7	slippage	slippage	NN
cord-321868-xk4yuibj	48	8	of	of	IN
cord-321868-xk4yuibj	48	9	tRNAs	trna	NNS
cord-321868-xk4yuibj	48	10	in	in	IN
cord-321868-xk4yuibj	48	11	the	the	DT
cord-321868-xk4yuibj	48	12	A	A	NNP
cord-321868-xk4yuibj	48	13	and	and	CC
cord-321868-xk4yuibj	48	14	P	p	NN
cord-321868-xk4yuibj	48	15	sites	site	NNS
cord-321868-xk4yuibj	48	16	of	of	IN
cord-321868-xk4yuibj	48	17	the	the	DT
cord-321868-xk4yuibj	48	18	translating	translate	VBG
cord-321868-xk4yuibj	48	19	ribosome	ribosome	NN
cord-321868-xk4yuibj	48	20	on	on	IN
cord-321868-xk4yuibj	48	21	the	the	DT
cord-321868-xk4yuibj	48	22	homopolymeric	homopolymeric	JJ
cord-321868-xk4yuibj	48	23	sequence	sequence	NN
cord-321868-xk4yuibj	48	24	results	result	VBZ
cord-321868-xk4yuibj	48	25	in	in	IN
cord-321868-xk4yuibj	48	26	a	a	DT
cord-321868-xk4yuibj	48	27	frameshift	frameshift	NN
cord-321868-xk4yuibj	48	28	to	to	IN
cord-321868-xk4yuibj	48	29	the	the	DT
cord-321868-xk4yuibj	48	30	pro	pro	JJ
cord-321868-xk4yuibj	48	31	orpol	orpol	JJ
cord-321868-xk4yuibj	48	32	reading	reading	NN
cord-321868-xk4yuibj	48	33	frame	frame	NN
cord-321868-xk4yuibj	48	34	and	and	CC
cord-321868-xk4yuibj	48	35	suppression	suppression	NN
cord-321868-xk4yuibj	48	36	of	of	IN
cord-321868-xk4yuibj	48	37	the	the	DT
cord-321868-xk4yuibj	48	38	gag	gag	NN
cord-321868-xk4yuibj	48	39	frame	frame	NN
cord-321868-xk4yuibj	48	40	termination	termination	NN
cord-321868-xk4yuibj	48	41	codon	codon	NN
cord-321868-xk4yuibj	48	42	.	.	.
cord-321868-xk4yuibj	49	1	This	this	DT
cord-321868-xk4yuibj	49	2	appears	appear	VBZ
cord-321868-xk4yuibj	49	3	not	not	RB
cord-321868-xk4yuibj	49	4	to	to	TO
cord-321868-xk4yuibj	49	5	be	be	VB
cord-321868-xk4yuibj	49	6	the	the	DT
cord-321868-xk4yuibj	49	7	case	case	NN
cord-321868-xk4yuibj	49	8	in	in	IN
cord-321868-xk4yuibj	49	9	Ty	Ty	NNP
cord-321868-xk4yuibj	49	10	elements	element	NNS
cord-321868-xk4yuibj	49	11	.	.	.
cord-321868-xk4yuibj	50	1	An	an	DT
cord-321868-xk4yuibj	50	2	In	in	IN
cord-321868-xk4yuibj	50	3	Vivo	Vivo	NNP
cord-321868-xk4yuibj	50	4	Assay	Assay	NNP
cord-321868-xk4yuibj	50	5	for	for	IN
cord-321868-xk4yuibj	50	6	Frameshifting	Frameshifting	NNP
cord-321868-xk4yuibj	51	1	All	all	DT
cord-321868-xk4yuibj	51	2	constructions	construction	NNS
cord-321868-xk4yuibj	51	3	involve	involve	VBP
cord-321868-xk4yuibj	51	4	the	the	DT
cord-321868-xk4yuibj	51	5	use	use	NN
cord-321868-xk4yuibj	51	6	of	of	IN
cord-321868-xk4yuibj	51	7	a	a	DT
cord-321868-xk4yuibj	51	8	HIS4A::lacZ	HIS4A::lacZ	NNP
cord-321868-xk4yuibj	51	9	fusion	fusion	NN
cord-321868-xk4yuibj	51	10	gene	gene	NN
cord-321868-xk4yuibj	51	11	contained	contain	VBN
cord-321868-xk4yuibj	51	12	on	on	IN
cord-321868-xk4yuibj	51	13	a	a	DT
cord-321868-xk4yuibj	51	14	2	2	CD
cord-321868-xk4yuibj	51	15	pm	p.m.	NN
cord-321868-xk4yuibj	51	16	DNA	dna	NN
cord-321868-xk4yuibj	51	17	-	-	HYPH
cord-321868-xk4yuibj	51	18	based	base	VBN
cord-321868-xk4yuibj	51	19	plasmid	plasmid	NN
cord-321868-xk4yuibj	51	20	whose	whose	WP$
cord-321868-xk4yuibj	51	21	construction	construction	NN
cord-321868-xk4yuibj	51	22	is	be	VBZ
cord-321868-xk4yuibj	51	23	described	describe	VBN
cord-321868-xk4yuibj	51	24	in	in	IN
cord-321868-xk4yuibj	51	25	Experimental	Experimental	NNP
cord-321868-xk4yuibj	51	26	Procedures	procedure	NNS
cord-321868-xk4yuibj	51	27	(	(	-LRB-
cord-321868-xk4yuibj	51	28	Figure	figure	NN
cord-321868-xk4yuibj	51	29	1	1	CD
cord-321868-xk4yuibj	51	30	)	)	-RRB-
cord-321868-xk4yuibj	51	31	.	.	.
cord-321868-xk4yuibj	52	1	This	this	DT
cord-321868-xk4yuibj	52	2	plasmid	plasmid	NN
cord-321868-xk4yuibj	52	3	is	be	VBZ
cord-321868-xk4yuibj	52	4	present	present	JJ
cord-321868-xk4yuibj	52	5	at	at	IN
cord-321868-xk4yuibj	52	6	four	four	CD
cord-321868-xk4yuibj	52	7	copies	copy	NNS
cord-321868-xk4yuibj	52	8	per	per	IN
cord-321868-xk4yuibj	52	9	cell	cell	NN
cord-321868-xk4yuibj	52	10	(	(	-LRB-
cord-321868-xk4yuibj	52	11	Farabaugh	Farabaugh	NNP
cord-321868-xk4yuibj	52	12	et	et	FW
cord-321868-xk4yuibj	52	13	al	al	NNP
cord-321868-xk4yuibj	52	14	.	.	NNP
cord-321868-xk4yuibj	52	15	,	,	,
cord-321868-xk4yuibj	52	16	1989	1989	CD
cord-321868-xk4yuibj	52	17	)	)	-RRB-
cord-321868-xk4yuibj	52	18	.	.	.
cord-321868-xk4yuibj	53	1	Oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	53	2	containing	contain	VBG
cord-321868-xk4yuibj	53	3	various	various	JJ
cord-321868-xk4yuibj	53	4	versions	version	NNS
cord-321868-xk4yuibj	53	5	of	of	IN
cord-321868-xk4yuibj	53	6	the	the	DT
cord-321868-xk4yuibj	53	7	frameshift	frameshift	NN
cord-321868-xk4yuibj	53	8	sequence	sequence	NN
cord-321868-xk4yuibj	53	9	were	be	VBD
cord-321868-xk4yuibj	53	10	introduced	introduce	VBN
cord-321868-xk4yuibj	53	11	at	at	IN
cord-321868-xk4yuibj	53	12	the	the	DT
cord-321868-xk4yuibj	53	13	BamHl	BamHl	NNP
cord-321868-xk4yuibj	53	14	site	site	NN
cord-321868-xk4yuibj	53	15	of	of	IN
cord-321868-xk4yuibj	53	16	pMB25	pmb25	NN
cord-321868-xk4yuibj	53	17	and	and	CC
cord-321868-xk4yuibj	53	18	between	between	IN
cord-321868-xk4yuibj	53	19	the	the	DT
cord-321868-xk4yuibj	53	20	BamHl	BamHl	NNP
cord-321868-xk4yuibj	53	21	and	and	CC
cord-321868-xk4yuibj	53	22	Kpnl	Kpnl	NNP
cord-321868-xk4yuibj	53	23	sites	site	NNS
cord-321868-xk4yuibj	53	24	of	of	IN
cord-321868-xk4yuibj	53	25	pMB38	pMB38	NNS
cord-321868-xk4yuibj	53	26	.	.	.
cord-321868-xk4yuibj	54	1	Transcription	transcription	NN
cord-321868-xk4yuibj	54	2	from	from	IN
cord-321868-xk4yuibj	54	3	the	the	DT
cord-321868-xk4yuibj	54	4	HIS4	HIS4	NNP
cord-321868-xk4yuibj	54	5	promoter	promoter	NN
cord-321868-xk4yuibj	54	6	produce8	produce8	NN
cord-321868-xk4yuibj	55	1	an	an	DT
cord-321868-xk4yuibj	55	2	mRNA	mrna	NN
cord-321868-xk4yuibj	55	3	with	with	IN
cord-321868-xk4yuibj	55	4	two	two	CD
cord-321868-xk4yuibj	55	5	overlapping	overlap	VBG
cord-321868-xk4yuibj	55	6	genes	gene	NNS
cord-321868-xk4yuibj	55	7	:	:	:
cord-321868-xk4yuibj	55	8	the	the	DT
cord-321868-xk4yuibj	55	9	5	5	CD
cord-321868-xk4yuibj	55	10	'	'	POS
cord-321868-xk4yuibj	55	11	proximal	proximal	JJ
cord-321868-xk4yuibj	55	12	gene	gene	NN
cord-321868-xk4yuibj	55	13	derived	derive	VBN
cord-321868-xk4yuibj	55	14	from	from	IN
cord-321868-xk4yuibj	55	15	the	the	DT
cord-321868-xk4yuibj	55	16	first	first	JJ
cord-321868-xk4yuibj	55	17	100	100	CD
cord-321868-xk4yuibj	55	18	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	55	19	of	of	IN
cord-321868-xk4yuibj	55	20	the	the	DT
cord-321868-xk4yuibj	55	21	HIS4A	HIS4A	NNP
cord-321868-xk4yuibj	55	22	gene	gene	NN
cord-321868-xk4yuibj	55	23	and	and	CC
cord-321868-xk4yuibj	55	24	,	,	,
cord-321868-xk4yuibj	55	25	in	in	IN
cord-321868-xk4yuibj	55	26	the	the	DT
cord-321868-xk4yuibj	55	27	+	+	CC
cord-321868-xk4yuibj	55	28	l	l	NN
cord-321868-xk4yuibj	55	29	reading	reading	NN
cord-321868-xk4yuibj	55	30	frame	frame	NN
cord-321868-xk4yuibj	55	31	,	,	,
cord-321868-xk4yuibj	55	32	the	the	DT
cord-321868-xk4yuibj	55	33	3'proximal	3'proximal	CD
cord-321868-xk4yuibj	55	34	gene	gene	NN
cord-321868-xk4yuibj	55	35	derived	derive	VBN
cord-321868-xk4yuibj	55	36	from	from	IN
cord-321868-xk4yuibj	55	37	the	the	DT
cord-321868-xk4yuibj	55	38	/acZ	/acZ	NNP
cord-321868-xk4yuibj	55	39	gene	gene	NN
cord-321868-xk4yuibj	55	40	of	of	IN
cord-321868-xk4yuibj	55	41	Escherichia	Escherichia	NNP
cord-321868-xk4yuibj	55	42	coli	coli	NNS
cord-321868-xk4yuibj	55	43	.	.	.
cord-321868-xk4yuibj	56	1	Production	production	NN
cord-321868-xk4yuibj	56	2	of	of	IN
cord-321868-xk4yuibj	56	3	the	the	DT
cord-321868-xk4yuibj	56	4	/acZ	/acZ	NNP
cord-321868-xk4yuibj	56	5	gene	gene	NN
cord-321868-xk4yuibj	56	6	product	product	NN
cord-321868-xk4yuibj	56	7	,	,	,
cord-321868-xk4yuibj	56	8	pgalactosidase	pgalactosidase	NNP
cord-321868-xk4yuibj	56	9	,	,	,
cord-321868-xk4yuibj	56	10	depends	depend	VBZ
cord-321868-xk4yuibj	56	11	upon	upon	IN
cord-321868-xk4yuibj	56	12	a	a	DT
cord-321868-xk4yuibj	56	13	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	56	14	frameshift	frameshift	NN
cord-321868-xk4yuibj	56	15	event	event	NN
cord-321868-xk4yuibj	56	16	in	in	IN
cord-321868-xk4yuibj	56	17	the	the	DT
cord-321868-xk4yuibj	56	18	+	+	CC
cord-321868-xk4yuibj	56	19	l	l	NN
cord-321868-xk4yuibj	56	20	direction	direction	NN
cord-321868-xk4yuibj	56	21	within	within	IN
cord-321868-xk4yuibj	56	22	the	the	DT
cord-321868-xk4yuibj	56	23	sequences	sequence	NNS
cord-321868-xk4yuibj	56	24	introduced	introduce	VBN
cord-321868-xk4yuibj	56	25	on	on	IN
cord-321868-xk4yuibj	56	26	the	the	DT
cord-321868-xk4yuibj	56	27	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	56	28	.	.	.
cord-321868-xk4yuibj	57	1	The	the	DT
cord-321868-xk4yuibj	57	2	rate	rate	NN
cord-321868-xk4yuibj	57	3	of	of	IN
cord-321868-xk4yuibj	57	4	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	57	5	is	be	VBZ
cord-321868-xk4yuibj	57	6	measured	measure	VBN
cord-321868-xk4yuibj	57	7	by	by	IN
cord-321868-xk4yuibj	57	8	determining	determine	VBG
cord-321868-xk4yuibj	57	9	the	the	DT
cord-321868-xk4yuibj	57	10	ratio	ratio	NN
cord-321868-xk4yuibj	57	11	of	of	IN
cord-321868-xk4yuibj	57	12	8-galactosidase	8-galactosidase	CD
cord-321868-xk4yuibj	57	13	activity	activity	NN
cord-321868-xk4yuibj	57	14	produced	produce	VBN
cord-321868-xk4yuibj	57	15	from	from	IN
cord-321868-xk4yuibj	57	16	a	a	DT
cord-321868-xk4yuibj	57	17	construct	construct	NN
cord-321868-xk4yuibj	57	18	requiring	require	VBG
cord-321868-xk4yuibj	57	19	a	a	DT
cord-321868-xk4yuibj	57	20	+	+	SYM
cord-321868-xk4yuibj	57	21	l	l	NN
cord-321868-xk4yuibj	57	22	frameshift	frameshift	NN
cord-321868-xk4yuibj	57	23	to	to	TO
cord-321868-xk4yuibj	57	24	express	express	VB
cord-321868-xk4yuibj	57	25	/acZ	/acZ	NNP
cord-321868-xk4yuibj	57	26	to	to	IN
cord-321868-xk4yuibj	57	27	that	that	DT
cord-321868-xk4yuibj	57	28	of	of	IN
cord-321868-xk4yuibj	57	29	a	a	DT
cord-321868-xk4yuibj	57	30	construct	construct	NN
cord-321868-xk4yuibj	57	31	in	in	IN
cord-321868-xk4yuibj	57	32	which	which	WDT
cord-321868-xk4yuibj	57	33	the	the	DT
cord-321868-xk4yuibj	57	34	upstream	upstream	JJ
cord-321868-xk4yuibj	57	35	and	and	CC
cord-321868-xk4yuibj	57	36	downstream	downstream	JJ
cord-321868-xk4yuibj	57	37	genes	gene	NNS
cord-321868-xk4yuibj	57	38	are	be	VBP
cord-321868-xk4yuibj	57	39	fused	fuse	VBN
cord-321868-xk4yuibj	57	40	in	in	IN
cord-321868-xk4yuibj	57	41	frame	frame	NN
cord-321868-xk4yuibj	57	42	.	.	.
cord-321868-xk4yuibj	58	1	As	as	IN
cord-321868-xk4yuibj	58	2	shown	show	VBN
cord-321868-xk4yuibj	58	3	below	below	RB
cord-321868-xk4yuibj	58	4	,	,	,
cord-321868-xk4yuibj	58	5	the	the	DT
cord-321868-xk4yuibj	58	6	rate	rate	NN
cord-321868-xk4yuibj	58	7	of	of	IN
cord-321868-xk4yuibj	58	8	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	58	9	measured	measure	VBN
cord-321868-xk4yuibj	58	10	in	in	IN
cord-321868-xk4yuibj	58	11	this	this	DT
cord-321868-xk4yuibj	58	12	way	way	NN
cord-321868-xk4yuibj	58	13	is	be	VBZ
cord-321868-xk4yuibj	58	14	high	high	JJ
cord-321868-xk4yuibj	58	15	,	,	,
cord-321868-xk4yuibj	58	16	usually	usually	RB
cord-321868-xk4yuibj	58	17	in	in	IN
cord-321868-xk4yuibj	58	18	the	the	DT
cord-321868-xk4yuibj	58	19	range	range	NN
cord-321868-xk4yuibj	58	20	of	of	IN
cord-321868-xk4yuibj	58	21	40	40	CD
cord-321868-xk4yuibj	58	22	%	%	NN
cord-321868-xk4yuibj	58	23	;	;	,
cord-321868-xk4yuibj	58	24	however	however	RB
cord-321868-xk4yuibj	58	25	,	,	,
cord-321868-xk4yuibj	58	26	experimental	experimental	JJ
cord-321868-xk4yuibj	58	27	variation	variation	NN
cord-321868-xk4yuibj	58	28	in	in	IN
cord-321868-xk4yuibj	58	29	this	this	DT
cord-321868-xk4yuibj	58	30	rate	rate	NN
cord-321868-xk4yuibj	58	31	occurs	occur	VBZ
cord-321868-xk4yuibj	58	32	,	,	,
cord-321868-xk4yuibj	58	33	both	both	CC
cord-321868-xk4yuibj	58	34	upward	upward	RB
cord-321868-xk4yuibj	58	35	to	to	IN
cord-321868-xk4yuibj	58	36	the	the	DT
cord-321868-xk4yuibj	58	37	range	range	NN
cord-321868-xk4yuibj	58	38	of	of	IN
cord-321868-xk4yuibj	58	39	80	80	CD
cord-321868-xk4yuibj	58	40	%	%	NN
cord-321868-xk4yuibj	58	41	and	and	CC
cord-321868-xk4yuibj	58	42	downward	downward	RB
cord-321868-xk4yuibj	58	43	in	in	IN
cord-321868-xk4yuibj	58	44	the	the	DT
cord-321868-xk4yuibj	58	45	range	range	NN
cord-321868-xk4yuibj	58	46	of	of	IN
cord-321868-xk4yuibj	58	47	20	20	CD
cord-321868-xk4yuibj	58	48	%	%	NN
cord-321868-xk4yuibj	58	49	.	.	.
cord-321868-xk4yuibj	59	1	This	this	DT
cord-321868-xk4yuibj	59	2	variation	variation	NN
cord-321868-xk4yuibj	59	3	results	result	VBZ
cord-321868-xk4yuibj	59	4	from	from	IN
cord-321868-xk4yuibj	59	5	unknown	unknown	JJ
cord-321868-xk4yuibj	59	6	effects	effect	NNS
cord-321868-xk4yuibj	59	7	of	of	IN
cord-321868-xk4yuibj	59	8	the	the	DT
cord-321868-xk4yuibj	59	9	sequence	sequence	NN
cord-321868-xk4yuibj	59	10	context	context	NN
cord-321868-xk4yuibj	59	11	of	of	IN
cord-321868-xk4yuibj	59	12	individual	individual	JJ
cord-321868-xk4yuibj	59	13	constructions	construction	NNS
cord-321868-xk4yuibj	59	14	and	and	CC
cord-321868-xk4yuibj	59	15	slight	slight	JJ
cord-321868-xk4yuibj	59	16	variations	variation	NNS
cord-321868-xk4yuibj	59	17	in	in	IN
cord-321868-xk4yuibj	59	18	the	the	DT
cord-321868-xk4yuibj	59	19	physiology	physiology	NN
cord-321868-xk4yuibj	59	20	of	of	IN
cord-321868-xk4yuibj	59	21	yeast	yeast	NN
cord-321868-xk4yuibj	59	22	transformants	transformant	NNS
cord-321868-xk4yuibj	59	23	.	.	.
cord-321868-xk4yuibj	60	1	We	-PRON-	PRP
cord-321868-xk4yuibj	60	2	will	will	MD
cord-321868-xk4yuibj	60	3	describe	describe	VB
cord-321868-xk4yuibj	60	4	as	as	RB
cord-321868-xk4yuibj	60	5	abnormal	abnormal	JJ
cord-321868-xk4yuibj	60	6	only	only	RB
cord-321868-xk4yuibj	60	7	those	those	DT
cord-321868-xk4yuibj	60	8	transformants	transformant	NNS
cord-321868-xk4yuibj	60	9	showing	show	VBG
cord-321868-xk4yuibj	60	10	rates	rate	NNS
cord-321868-xk4yuibj	60	11	of	of	IN
cord-321868-xk4yuibj	60	12	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	60	13	substantially	substantially	RB
cord-321868-xk4yuibj	60	14	lower	low	JJR
cord-321868-xk4yuibj	60	15	than	than	IN
cord-321868-xk4yuibj	60	16	20	20	CD
cord-321868-xk4yuibj	60	17	%	%	NN
cord-321868-xk4yuibj	60	18	(	(	-LRB-
cord-321868-xk4yuibj	60	19	i.e.	i.e.	FW
cord-321868-xk4yuibj	60	20	,	,	,
cord-321868-xk4yuibj	60	21	in	in	IN
cord-321868-xk4yuibj	60	22	the	the	DT
cord-321868-xk4yuibj	60	23	range	range	NN
cord-321868-xk4yuibj	60	24	of	of	IN
cord-321868-xk4yuibj	60	25	2	2	CD
cord-321868-xk4yuibj	60	26	%	%	NN
cord-321868-xk4yuibj	60	27	or	or	CC
cord-321868-xk4yuibj	60	28	less	less	JJR
cord-321868-xk4yuibj	60	29	)	)	-RRB-
cord-321868-xk4yuibj	60	30	.	.	.
cord-321868-xk4yuibj	61	1	Sequence	sequence	NN
cord-321868-xk4yuibj	61	2	Is	be	VBZ
cord-321868-xk4yuibj	61	3	the	the	DT
cord-321868-xk4yuibj	61	4	Site	Site	NNP
cord-321868-xk4yuibj	61	5	of	of	IN
cord-321868-xk4yuibj	61	6	Frameshifting	Frameshifting	NNP
cord-321868-xk4yuibj	62	1	We	-PRON-	PRP
cord-321868-xk4yuibj	62	2	previously	previously	RB
cord-321868-xk4yuibj	62	3	demonstrated	demonstrate	VBD
cord-321868-xk4yuibj	62	4	that	that	IN
cord-321868-xk4yuibj	62	5	a	a	DT
cord-321868-xk4yuibj	62	6	14	14	CD
cord-321868-xk4yuibj	62	7	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	62	8	sequence	sequence	NN
cord-321868-xk4yuibj	62	9	conserved	conserve	VBN
cord-321868-xk4yuibj	62	10	between	between	IN
cord-321868-xk4yuibj	62	11	the	the	DT
cord-321868-xk4yuibj	62	12	Tyl	Tyl	NNP
cord-321868-xk4yuibj	62	13	and	and	CC
cord-321868-xk4yuibj	62	14	Ty2	ty2	CD
cord-321868-xk4yuibj	62	15	families	family	NNS
cord-321868-xk4yuibj	62	16	of	of	IN
cord-321868-xk4yuibj	62	17	Ty	Ty	NNP
cord-321868-xk4yuibj	62	18	elements	element	NNS
cord-321868-xk4yuibj	62	19	supports	support	VBZ
cord-321868-xk4yuibj	62	20	high	high	JJ
cord-321868-xk4yuibj	62	21	levels	level	NNS
cord-321868-xk4yuibj	62	22	of	of	IN
cord-321868-xk4yuibj	62	23	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	63	1	(	(	-LRB-
cord-321868-xk4yuibj	63	2	Clare	Clare	NNP
cord-321868-xk4yuibj	63	3	et	et	NNP
cord-321868-xk4yuibj	63	4	al	al	NNP
cord-321868-xk4yuibj	63	5	,	,	,
cord-321868-xk4yuibj	63	6	,	,	,
cord-321868-xk4yuibj	63	7	1988	1988	CD
cord-321868-xk4yuibj	63	8	)	)	-RRB-
cord-321868-xk4yuibj	63	9	.	.	.
cord-321868-xk4yuibj	64	1	It	-PRON-	PRP
cord-321868-xk4yuibj	64	2	is	be	VBZ
cord-321868-xk4yuibj	64	3	possible	possible	JJ
cord-321868-xk4yuibj	64	4	that	that	IN
cord-321868-xk4yuibj	64	5	the	the	DT
cord-321868-xk4yuibj	64	6	frameshift	frameshift	NN
cord-321868-xk4yuibj	64	7	event	event	NN
cord-321868-xk4yuibj	64	8	occurs	occur	VBZ
cord-321868-xk4yuibj	64	9	shortly	shortly	RB
cord-321868-xk4yuibj	64	10	before	before	IN
cord-321868-xk4yuibj	64	11	or	or	CC
cord-321868-xk4yuibj	64	12	after	after	IN
cord-321868-xk4yuibj	64	13	the	the	DT
cord-321868-xk4yuibj	64	14	14	14	CD
cord-321868-xk4yuibj	64	15	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	64	16	sequence	sequence	NN
cord-321868-xk4yuibj	64	17	since	since	IN
cord-321868-xk4yuibj	64	18	neither	neither	CC
cord-321868-xk4yuibj	64	19	the	the	DT
cord-321868-xk4yuibj	64	20	NA	NA	NNP
cord-321868-xk4yuibj	64	21	nor	nor	CC
cord-321868-xk4yuibj	64	22	the	the	DT
cord-321868-xk4yuibj	64	23	TYB	TYB	NNP
cord-321868-xk4yuibj	64	24	reading	reading	NN
cord-321868-xk4yuibj	64	25	frame	frame	NN
cord-321868-xk4yuibj	64	26	is	be	VBZ
cord-321868-xk4yuibj	64	27	limited	limit	VBN
cord-321868-xk4yuibj	64	28	by	by	IN
cord-321868-xk4yuibj	64	29	translational	translational	JJ
cord-321868-xk4yuibj	64	30	termination	termination	NN
cord-321868-xk4yuibj	64	31	codons	codon	NNS
cord-321868-xk4yuibj	64	32	in	in	IN
cord-321868-xk4yuibj	64	33	the	the	DT
cord-321868-xk4yuibj	64	34	region	region	NN
cord-321868-xk4yuibj	64	35	of	of	IN
cord-321868-xk4yuibj	64	36	overlap	overlap	NN
cord-321868-xk4yuibj	64	37	.	.	.
cord-321868-xk4yuibj	65	1	In	in	IN
cord-321868-xk4yuibj	65	2	the	the	DT
cord-321868-xk4yuibj	65	3	construction	construction	NN
cord-321868-xk4yuibj	65	4	used	use	VBN
cord-321868-xk4yuibj	65	5	,	,	,
cord-321868-xk4yuibj	65	6	the	the	DT
cord-321868-xk4yuibj	65	7	first	first	JJ
cord-321868-xk4yuibj	65	8	NB	NB	NNP
cord-321868-xk4yuibj	65	9	frame	frame	NN
cord-321868-xk4yuibj	65	10	termination	termination	NN
cord-321868-xk4yuibj	65	11	codon	codon	NN
cord-321868-xk4yuibj	65	12	is	be	VBZ
cord-321868-xk4yuibj	65	13	72	72	CD
cord-321868-xk4yuibj	65	14	bp	bp	NNP
cord-321868-xk4yuibj	65	15	upstream	upstream	RB
cord-321868-xk4yuibj	65	16	of	of	IN
cord-321868-xk4yuibj	65	17	the	the	DT
cord-321868-xk4yuibj	65	18	overlap	overlap	NN
cord-321868-xk4yuibj	65	19	in	in	IN
cord-321868-xk4yuibj	65	20	HIS4A	HIS4A	NNP
cord-321868-xk4yuibj	65	21	while	while	IN
cord-321868-xk4yuibj	65	22	the	the	DT
cord-321868-xk4yuibj	65	23	first	first	JJ
cord-321868-xk4yuibj	65	24	NA	NA	NNP
cord-321868-xk4yuibj	65	25	frame	frame	NN
cord-321868-xk4yuibj	65	26	termination	termination	NN
cord-321868-xk4yuibj	65	27	codon	codon	NN
cord-321868-xk4yuibj	65	28	is	be	VBZ
cord-321868-xk4yuibj	65	29	25	25	CD
cord-321868-xk4yuibj	65	30	bp	bp	NNP
cord-321868-xk4yuibj	65	31	downstream	downstream	NN
cord-321868-xk4yuibj	65	32	in	in	IN
cord-321868-xk4yuibj	65	33	/acZ.	/acZ.	NNP
cord-321868-xk4yuibj	66	1	An	an	DT
cord-321868-xk4yuibj	66	2	oligonucleotide	oligonucleotide	NN
cord-321868-xk4yuibj	66	3	was	be	VBD
cord-321868-xk4yuibj	66	4	synthesized	synthesize	VBN
cord-321868-xk4yuibj	66	5	that	that	WDT
cord-321868-xk4yuibj	66	6	contained	contain	VBD
cord-321868-xk4yuibj	66	7	the	the	DT
cord-321868-xk4yuibj	66	8	14	14	CD
cord-321868-xk4yuibj	66	9	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	66	10	frameshift	frameshift	NN
cord-321868-xk4yuibj	66	11	sequence	sequence	NN
cord-321868-xk4yuibj	66	12	flanked	flank	VBN
cord-321868-xk4yuibj	66	13	by	by	IN
cord-321868-xk4yuibj	66	14	termination	termination	NN
cord-321868-xk4yuibj	66	15	codons	codon	NNS
cord-321868-xk4yuibj	66	16	,	,	,
cord-321868-xk4yuibj	66	17	upstream	upstream	RB
cord-321868-xk4yuibj	66	18	in	in	IN
cord-321868-xk4yuibj	66	19	the	the	DT
cord-321868-xk4yuibj	66	20	TYB	TYB	NNP
cord-321868-xk4yuibj	66	21	reading	reading	NN
cord-321868-xk4yuibj	66	22	frame	frame	NN
cord-321868-xk4yuibj	66	23	and	and	CC
cord-321868-xk4yuibj	66	24	downstream	downstream	RB
cord-321868-xk4yuibj	66	25	in	in	IN
cord-321868-xk4yuibj	66	26	the	the	DT
cord-321868-xk4yuibj	66	27	NA	NA	NNP
cord-321868-xk4yuibj	66	28	reading	reading	NN
cord-321868-xk4yuibj	66	29	frame	frame	NN
cord-321868-xk4yuibj	66	30	(	(	-LRB-
cord-321868-xk4yuibj	66	31	Table	Table	NNP
cord-321868-xk4yuibj	66	32	7	7	CD
cord-321868-xk4yuibj	66	33	)	)	-RRB-
cord-321868-xk4yuibj	66	34	.	.	.
cord-321868-xk4yuibj	67	1	The	the	DT
cord-321868-xk4yuibj	67	2	oligo	oligo	NN
cord-321868-xk4yuibj	67	3	-	-	HYPH
cord-321868-xk4yuibj	67	4	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	67	5	was	be	VBD
cord-321868-xk4yuibj	67	6	cloned	clone	VBN
cord-321868-xk4yuibj	67	7	at	at	IN
cord-321868-xk4yuibj	67	8	the	the	DT
cord-321868-xk4yuibj	67	9	BamHl	BamHl	NNP
cord-321868-xk4yuibj	67	10	site	site	NN
cord-321868-xk4yuibj	67	11	of	of	IN
cord-321868-xk4yuibj	67	12	pMB25	pMB25	NNP
cord-321868-xk4yuibj	67	13	as	as	IN
cord-321868-xk4yuibj	67	14	described	describe	VBN
cord-321868-xk4yuibj	67	15	in	in	IN
cord-321868-xk4yuibj	67	16	Experimental	Experimental	NNP
cord-321868-xk4yuibj	67	17	Procedures	procedure	NNS
cord-321868-xk4yuibj	67	18	and	and	CC
cord-321868-xk4yuibj	67	19	analyzed	analyze	VBD
cord-321868-xk4yuibj	67	20	for	for	IN
cord-321868-xk4yuibj	67	21	its	-PRON-	PRP$
cord-321868-xk4yuibj	67	22	ability	ability	NN
cord-321868-xk4yuibj	67	23	to	to	TO
cord-321868-xk4yuibj	67	24	promote	promote	VB
cord-321868-xk4yuibj	67	25	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	67	26	by	by	IN
cord-321868-xk4yuibj	67	27	assaying	assay	VBG
cord-321868-xk4yuibj	67	28	the	the	DT
cord-321868-xk4yuibj	67	29	expression	expression	NN
cord-321868-xk4yuibj	67	30	of	of	IN
cord-321868-xk4yuibj	67	31	the	the	DT
cord-321868-xk4yuibj	67	32	downstream	downstream	JJ
cord-321868-xk4yuibj	67	33	gene	gene	NN
cord-321868-xk4yuibj	67	34	,	,	,
cord-321868-xk4yuibj	67	35	/acZ.	/acZ.	NNP
cord-321868-xk4yuibj	68	1	Expression	expression	NN
cord-321868-xk4yuibj	68	2	of	of	IN
cord-321868-xk4yuibj	68	3	/acZ	/acZ	NNP
cord-321868-xk4yuibj	68	4	requires	require	VBZ
cord-321868-xk4yuibj	68	5	a	a	DT
cord-321868-xk4yuibj	68	6	+	+	FW
cord-321868-xk4yuibj	68	7	l	l	NN
cord-321868-xk4yuibj	68	8	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	68	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	68	10	within	within	IN
cord-321868-xk4yuibj	68	11	the	the	DT
cord-321868-xk4yuibj	68	12	sequence	sequence	NN
cord-321868-xk4yuibj	68	13	between	between	IN
cord-321868-xk4yuibj	68	14	the	the	DT
cord-321868-xk4yuibj	68	15	termination	termination	NN
cord-321868-xk4yuibj	68	16	codons	codon	NNS
cord-321868-xk4yuibj	68	17	.	.	.
cord-321868-xk4yuibj	69	1	Frameshifting	Frameshifting	NNP
cord-321868-xk4yuibj	69	2	is	be	VBZ
cord-321868-xk4yuibj	69	3	unaffected	unaffected	JJ
cord-321868-xk4yuibj	69	4	by	by	IN
cord-321868-xk4yuibj	69	5	the	the	DT
cord-321868-xk4yuibj	69	6	termination	termination	NN
cord-321868-xk4yuibj	69	7	codons	codon	NNS
cord-321868-xk4yuibj	69	8	,	,	,
cord-321868-xk4yuibj	69	9	occurring	occur	VBG
cord-321868-xk4yuibj	69	10	at	at	IN
cord-321868-xk4yuibj	69	11	levels	level	NNS
cord-321868-xk4yuibj	69	12	of	of	IN
cord-321868-xk4yuibj	69	13	approximately	approximately	RB
cord-321868-xk4yuibj	69	14	25	25	CD
cord-321868-xk4yuibj	69	15	%	%	NN
cord-321868-xk4yuibj	69	16	(	(	-LRB-
cord-321868-xk4yuibj	69	17	data	datum	NNS
cord-321868-xk4yuibj	69	18	not	not	RB
cord-321868-xk4yuibj	69	19	shown	show	VBN
cord-321868-xk4yuibj	69	20	)	)	-RRB-
cord-321868-xk4yuibj	69	21	.	.	.
cord-321868-xk4yuibj	70	1	This	this	DT
cord-321868-xk4yuibj	70	2	result	result	NN
cord-321868-xk4yuibj	70	3	demonstrates	demonstrate	VBZ
cord-321868-xk4yuibj	70	4	that	that	IN
cord-321868-xk4yuibj	70	5	the	the	DT
cord-321868-xk4yuibj	70	6	14	14	CD
cord-321868-xk4yuibj	70	7	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	70	8	sequence	sequence	NN
cord-321868-xk4yuibj	70	9	is	be	VBZ
cord-321868-xk4yuibj	70	10	the	the	DT
cord-321868-xk4yuibj	70	11	actual	actual	JJ
cord-321868-xk4yuibj	70	12	site	site	NN
cord-321868-xk4yuibj	70	13	of	of	IN
cord-321868-xk4yuibj	70	14	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	70	15	.	.	.
cord-321868-xk4yuibj	71	1	An	an	DT
cord-321868-xk4yuibj	71	2	open	open	JJ
cord-321868-xk4yuibj	71	3	question	question	NN
cord-321868-xk4yuibj	71	4	in	in	IN
cord-321868-xk4yuibj	71	5	many	many	JJ
cord-321868-xk4yuibj	71	6	of	of	IN
cord-321868-xk4yuibj	71	7	the	the	DT
cord-321868-xk4yuibj	71	8	site	site	NN
cord-321868-xk4yuibj	71	9	-	-	HYPH
cord-321868-xk4yuibj	71	10	specific	specific	JJ
cord-321868-xk4yuibj	71	11	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	71	12	systems	system	NNS
cord-321868-xk4yuibj	71	13	described	describe	VBN
cord-321868-xk4yuibj	71	14	in	in	IN
cord-321868-xk4yuibj	71	15	prokaryotes	prokaryote	NNS
cord-321868-xk4yuibj	71	16	and	and	CC
cord-321868-xk4yuibj	71	17	eukaryotes	eukaryote	NNS
cord-321868-xk4yuibj	71	18	is	be	VBZ
cord-321868-xk4yuibj	71	19	the	the	DT
cord-321868-xk4yuibj	71	20	degree	degree	NN
cord-321868-xk4yuibj	71	21	to	to	TO
cord-321868-xk4yuibj	71	22	which	which	WDT
cord-321868-xk4yuibj	71	23	the	the	DT
cord-321868-xk4yuibj	71	24	event	event	NN
cord-321868-xk4yuibj	71	25	is	be	VBZ
cord-321868-xk4yuibj	71	26	directional	directional	JJ
cord-321868-xk4yuibj	71	27	and	and	CC
cord-321868-xk4yuibj	71	28	reading	read	VBG
cord-321868-xk4yuibj	71	29	frame	frame	NN
cord-321868-xk4yuibj	71	30	specific	specific	JJ
cord-321868-xk4yuibj	71	31	.	.	.
cord-321868-xk4yuibj	72	1	Is	be	VBZ
cord-321868-xk4yuibj	72	2	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	72	3	constrained	constrain	VBN
cord-321868-xk4yuibj	72	4	to	to	TO
cord-321868-xk4yuibj	72	5	occur	occur	VB
cord-321868-xk4yuibj	72	6	in	in	IN
cord-321868-xk4yuibj	72	7	only	only	RB
cord-321868-xk4yuibj	72	8	one	one	CD
cord-321868-xk4yuibj	72	9	direction	direction	NN
cord-321868-xk4yuibj	72	10	,	,	,
cord-321868-xk4yuibj	72	11	or	or	CC
cord-321868-xk4yuibj	72	12	can	can	MD
cord-321868-xk4yuibj	72	13	it	-PRON-	PRP
cord-321868-xk4yuibj	72	14	occur	occur	VB
cord-321868-xk4yuibj	72	15	in	in	IN
cord-321868-xk4yuibj	72	16	either	either	DT
cord-321868-xk4yuibj	72	17	direction	direction	NN
cord-321868-xk4yuibj	72	18	?	?	.
cord-321868-xk4yuibj	73	1	Frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	73	2	in	in	IN
cord-321868-xk4yuibj	73	3	the	the	DT
cord-321868-xk4yuibj	73	4	human	human	JJ
cord-321868-xk4yuibj	73	5	immunodeficiencyvirus	immunodeficiencyvirus	NN
cord-321868-xk4yuibj	73	6	(	(	-LRB-
cord-321868-xk4yuibj	73	7	HIV-1	HIV-1	NNP
cord-321868-xk4yuibj	73	8	)	)	-RRB-
cord-321868-xk4yuibj	73	9	occurs	occur	VBZ
cord-321868-xk4yuibj	73	10	only	only	RB
cord-321868-xk4yuibj	73	11	in	in	IN
cord-321868-xk4yuibj	73	12	the	the	DT
cord-321868-xk4yuibj	73	13	-1	-1	NN
cord-321868-xk4yuibj	73	14	direction	direction	NN
cord-321868-xk4yuibj	74	1	(	(	-LRB-
cord-321868-xk4yuibj	74	2	Wilson	Wilson	NNP
cord-321868-xk4yuibj	74	3	et	et	NNP
cord-321868-xk4yuibj	74	4	al	al	NNP
cord-321868-xk4yuibj	74	5	.	.	NNP
cord-321868-xk4yuibj	74	6	,	,	,
cord-321868-xk4yuibj	74	7	1988	1988	CD
cord-321868-xk4yuibj	74	8	)	)	-RRB-
cord-321868-xk4yuibj	74	9	.	.	.
cord-321868-xk4yuibj	75	1	Conversely	conversely	RB
cord-321868-xk4yuibj	75	2	,	,	,
cord-321868-xk4yuibj	75	3	Weiss	Weiss	NNP
cord-321868-xk4yuibj	75	4	et	et	NNP
cord-321868-xk4yuibj	75	5	al	al	NNP
cord-321868-xk4yuibj	75	6	.	.	.
cord-321868-xk4yuibj	76	1	(	(	-LRB-
cord-321868-xk4yuibj	76	2	1987	1987	CD
cord-321868-xk4yuibj	76	3	)	)	-RRB-
cord-321868-xk4yuibj	76	4	demonstrated	demonstrate	VBD
cord-321868-xk4yuibj	76	5	that	that	IN
cord-321868-xk4yuibj	76	6	ribosomes	ribosome	NNS
cord-321868-xk4yuibj	76	7	in	in	IN
cord-321868-xk4yuibj	76	8	E.	E.	NNP
cord-321868-xk4yuibj	76	9	coli	coli	NNS
cord-321868-xk4yuibj	76	10	may	may	MD
cord-321868-xk4yuibj	76	11	be	be	VB
cord-321868-xk4yuibj	76	12	made	make	VBN
cord-321868-xk4yuibj	76	13	to	to	TO
cord-321868-xk4yuibj	76	14	frameshift	frameshift	VB
cord-321868-xk4yuibj	76	15	both	both	DT
cord-321868-xk4yuibj	76	16	forward	forward	RB
cord-321868-xk4yuibj	76	17	and	and	CC
cord-321868-xk4yuibj	76	18	backward	backward	RB
cord-321868-xk4yuibj	76	19	within	within	IN
cord-321868-xk4yuibj	76	20	a	a	DT
cord-321868-xk4yuibj	76	21	sequence	sequence	NN
cord-321868-xk4yuibj	76	22	that	that	WDT
cord-321868-xk4yuibj	76	23	incorporates	incorporate	VBZ
cord-321868-xk4yuibj	76	24	a	a	DT
cord-321868-xk4yuibj	76	25	string	string	NN
cord-321868-xk4yuibj	76	26	of	of	IN
cord-321868-xk4yuibj	76	27	identical	identical	JJ
cord-321868-xk4yuibj	76	28	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	76	29	.	.	.
cord-321868-xk4yuibj	77	1	Shifts	shift	NNS
cord-321868-xk4yuibj	77	2	of	of	IN
cord-321868-xk4yuibj	77	3	-2	-2	NNP
cord-321868-xk4yuibj	77	4	,	,	,
cord-321868-xk4yuibj	77	5	-1	-1	NNP
cord-321868-xk4yuibj	77	6	,	,	,
cord-321868-xk4yuibj	77	7	+	+	CC
cord-321868-xk4yuibj	78	1	l	l	NNP
cord-321868-xk4yuibj	78	2	,	,	,
cord-321868-xk4yuibj	78	3	+2	+2	NNP
cord-321868-xk4yuibj	78	4	,	,	,
cord-321868-xk4yuibj	78	5	+5	+5	NNP
cord-321868-xk4yuibj	78	6	,	,	,
cord-321868-xk4yuibj	78	7	and	and	CC
cord-321868-xk4yuibj	78	8	+6	+6	CD
cord-321868-xk4yuibj	78	9	were	be	VBD
cord-321868-xk4yuibj	78	10	identified	identify	VBN
cord-321868-xk4yuibj	78	11	.	.	.
cord-321868-xk4yuibj	79	1	Will	Will	MD
cord-321868-xk4yuibj	79	2	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	79	3	occur	occur	VBP
cord-321868-xk4yuibj	79	4	only	only	RB
cord-321868-xk4yuibj	79	5	when	when	WRB
cord-321868-xk4yuibj	79	6	the	the	DT
cord-321868-xk4yuibj	79	7	TYA	TYA	NNP
cord-321868-xk4yuibj	79	8	reading	reading	NN
cord-321868-xk4yuibj	79	9	frame	frame	NN
cord-321868-xk4yuibj	79	10	is	be	VBZ
cord-321868-xk4yuibj	79	11	being	be	VBG
cord-321868-xk4yuibj	79	12	translated	translate	VBN
cord-321868-xk4yuibj	79	13	by	by	IN
cord-321868-xk4yuibj	79	14	the	the	DT
cord-321868-xk4yuibj	79	15	ribosome	ribosome	NN
cord-321868-xk4yuibj	79	16	?	?	.
cord-321868-xk4yuibj	80	1	Changing	change	VBG
cord-321868-xk4yuibj	80	2	the	the	DT
cord-321868-xk4yuibj	80	3	reading	reading	NN
cord-321868-xk4yuibj	80	4	frame	frame	NN
cord-321868-xk4yuibj	80	5	of	of	IN
cord-321868-xk4yuibj	80	6	E.	E.	NNP
cord-321868-xk4yuibj	80	7	coli	coli	NNS
cord-321868-xk4yuibj	81	1	frameshift	frameshift	NN
cord-321868-xk4yuibj	81	2	sites	site	NNS
cord-321868-xk4yuibj	81	3	decreases	decrease	VBZ
cord-321868-xk4yuibj	81	4	the	the	DT
cord-321868-xk4yuibj	81	5	frequency	frequency	NN
cord-321868-xk4yuibj	81	6	of	of	IN
cord-321868-xk4yuibj	81	7	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	81	8	by	by	IN
cord-321868-xk4yuibj	81	9	about	about	IN
cord-321868-xk4yuibj	81	10	lOO	lOO	NNP
cord-321868-xk4yuibj	81	11	-	-	HYPH
cord-321868-xk4yuibj	81	12	fold	fold	JJ
cord-321868-xk4yuibj	81	13	(	(	-LRB-
cord-321868-xk4yuibj	81	14	Weiss	Weiss	NNP
cord-321868-xk4yuibj	81	15	et	et	NNP
cord-321868-xk4yuibj	81	16	al	al	NNP
cord-321868-xk4yuibj	81	17	.	.	NNP
cord-321868-xk4yuibj	81	18	,	,	,
cord-321868-xk4yuibj	81	19	1987	1987	CD
cord-321868-xk4yuibj	81	20	)	)	-RRB-
cord-321868-xk4yuibj	81	21	.	.	.
cord-321868-xk4yuibj	82	1	Changing	change	VBG
cord-321868-xk4yuibj	82	2	the	the	DT
cord-321868-xk4yuibj	82	3	frame	frame	NN
cord-321868-xk4yuibj	82	4	disrupts	disrupt	VBZ
cord-321868-xk4yuibj	82	5	both	both	CC
cord-321868-xk4yuibj	82	6	a	a	DT
cord-321868-xk4yuibj	82	7	required	require	VBN
cord-321868-xk4yuibj	82	8	frame	frame	NN
cord-321868-xk4yuibj	82	9	-	-	HYPH
cord-321868-xk4yuibj	82	10	specific	specific	JJ
cord-321868-xk4yuibj	82	11	pause	pause	NN
cord-321868-xk4yuibj	82	12	induced	induce	VBN
cord-321868-xk4yuibj	82	13	by	by	IN
cord-321868-xk4yuibj	82	14	a	a	DT
cord-321868-xk4yuibj	82	15	nonsense	nonsense	NN
cord-321868-xk4yuibj	82	16	codon	codon	NN
cord-321868-xk4yuibj	82	17	,	,	,
cord-321868-xk4yuibj	82	18	and	and	CC
cord-321868-xk4yuibj	82	19	a	a	DT
cord-321868-xk4yuibj	82	20	frame	frame	NN
cord-321868-xk4yuibj	82	21	-	-	HYPH
cord-321868-xk4yuibj	82	22	specific	specific	JJ
cord-321868-xk4yuibj	82	23	tRNA	trna	NN
cord-321868-xk4yuibj	82	24	slippage	slippage	NN
cord-321868-xk4yuibj	82	25	site	site	NN
cord-321868-xk4yuibj	82	26	.	.	.
cord-321868-xk4yuibj	83	1	Removing	remove	VBG
cord-321868-xk4yuibj	83	2	the	the	DT
cord-321868-xk4yuibj	83	3	nonsense	nonsense	NN
cord-321868-xk4yuibj	83	4	codon	codon	NN
cord-321868-xk4yuibj	83	5	alone	alone	RB
cord-321868-xk4yuibj	83	6	causes	cause	VBZ
cord-321868-xk4yuibj	83	7	about	about	IN
cord-321868-xk4yuibj	83	8	a	a	DT
cord-321868-xk4yuibj	83	9	lo	lo	NN
cord-321868-xk4yuibj	83	10	-	-	JJ
cord-321868-xk4yuibj	83	11	fold	fold	JJ
cord-321868-xk4yuibj	83	12	decrease	decrease	NN
cord-321868-xk4yuibj	83	13	in	in	IN
cord-321868-xk4yuibj	83	14	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	83	15	.	.	.
cord-321868-xk4yuibj	84	1	This	this	DT
cord-321868-xk4yuibj	84	2	suggests	suggest	VBZ
cord-321868-xk4yuibj	84	3	that	that	IN
cord-321868-xk4yuibj	84	4	reading	read	VBG
cord-321868-xk4yuibj	84	5	frame	frame	NN
cord-321868-xk4yuibj	84	6	is	be	VBZ
cord-321868-xk4yuibj	84	7	important	important	JJ
cord-321868-xk4yuibj	84	8	in	in	IN
cord-321868-xk4yuibj	84	9	the	the	DT
cord-321868-xk4yuibj	84	10	E.	E.	NNP
cord-321868-xk4yuibj	84	11	coli	coli	NNS
cord-321868-xk4yuibj	84	12	case	case	NN
cord-321868-xk4yuibj	84	13	,	,	,
cord-321868-xk4yuibj	84	14	but	but	CC
cord-321868-xk4yuibj	84	15	not	not	RB
cord-321868-xk4yuibj	84	16	essential	essential	JJ
cord-321868-xk4yuibj	84	17	.	.	.
cord-321868-xk4yuibj	85	1	To	to	TO
cord-321868-xk4yuibj	85	2	test	test	VB
cord-321868-xk4yuibj	85	3	explicitly	explicitly	RB
cord-321868-xk4yuibj	85	4	if	if	IN
cord-321868-xk4yuibj	85	5	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	85	6	is	be	VBZ
cord-321868-xk4yuibj	85	7	reading	read	VBG
cord-321868-xk4yuibj	85	8	frame	frame	NN
cord-321868-xk4yuibj	85	9	specific	specific	JJ
cord-321868-xk4yuibj	85	10	or	or	CC
cord-321868-xk4yuibj	85	11	directional	directional	JJ
cord-321868-xk4yuibj	85	12	,	,	,
cord-321868-xk4yuibj	85	13	we	-PRON-	PRP
cord-321868-xk4yuibj	85	14	constructed	construct	VBD
cord-321868-xk4yuibj	85	15	a	a	DT
cord-321868-xk4yuibj	85	16	set	set	NN
cord-321868-xk4yuibj	85	17	of	of	IN
cord-321868-xk4yuibj	85	18	plasmids	plasmid	NNS
cord-321868-xk4yuibj	85	19	all	all	DT
cord-321868-xk4yuibj	85	20	of	of	IN
cord-321868-xk4yuibj	85	21	which	which	WDT
cord-321868-xk4yuibj	85	22	had	have	VBD
cord-321868-xk4yuibj	85	23	a	a	DT
cord-321868-xk4yuibj	85	24	single	single	JJ
cord-321868-xk4yuibj	85	25	insert	insert	NN
cord-321868-xk4yuibj	85	26	of	of	IN
cord-321868-xk4yuibj	85	27	the	the	DT
cord-321868-xk4yuibj	85	28	minimal	minimal	JJ
cord-321868-xk4yuibj	85	29	region	region	NN
cord-321868-xk4yuibj	85	30	but	but	CC
cord-321868-xk4yuibj	85	31	designed	design	VBN
cord-321868-xk4yuibj	85	32	such	such	PDT
cord-321868-xk4yuibj	85	33	that	that	DT
cord-321868-xk4yuibj	85	34	translation	translation	NN
cord-321868-xk4yuibj	85	35	comes	come	VBZ
cord-321868-xk4yuibj	85	36	into	into	IN
cord-321868-xk4yuibj	85	37	the	the	DT
cord-321868-xk4yuibj	85	38	region	region	NN
cord-321868-xk4yuibj	85	39	in	in	IN
cord-321868-xk4yuibj	85	40	each	each	DT
cord-321868-xk4yuibj	85	41	of	of	IN
cord-321868-xk4yuibj	85	42	the	the	DT
cord-321868-xk4yuibj	85	43	three	three	CD
cord-321868-xk4yuibj	85	44	reading	read	VBG
cord-321868-xk4yuibj	85	45	frames	frame	NNS
cord-321868-xk4yuibj	85	46	and	and	CC
cord-321868-xk4yuibj	85	47	exits	exit	NNS
cord-321868-xk4yuibj	85	48	in	in	IN
cord-321868-xk4yuibj	85	49	each	each	DT
cord-321868-xk4yuibj	85	50	of	of	IN
cord-321868-xk4yuibj	85	51	the	the	DT
cord-321868-xk4yuibj	85	52	three	three	CD
cord-321868-xk4yuibj	85	53	reading	reading	NN
cord-321868-xk4yuibj	85	54	frames	frame	NNS
cord-321868-xk4yuibj	85	55	(	(	-LRB-
cord-321868-xk4yuibj	85	56	Table	table	NN
cord-321868-xk4yuibj	85	57	1	1	CD
cord-321868-xk4yuibj	85	58	)	)	-RRB-
cord-321868-xk4yuibj	85	59	.	.	.
cord-321868-xk4yuibj	86	1	To	to	TO
cord-321868-xk4yuibj	86	2	achieve	achieve	VB
cord-321868-xk4yuibj	86	3	all	all	DT
cord-321868-xk4yuibj	86	4	combinations	combination	NNS
cord-321868-xk4yuibj	86	5	required	require	VBD
cord-321868-xk4yuibj	86	6	constructing	construct	VBG
cord-321868-xk4yuibj	86	7	nine	nine	CD
cord-321868-xk4yuibj	86	8	plasmids	plasmid	NNS
cord-321868-xk4yuibj	86	9	.	.	.
cord-321868-xk4yuibj	87	1	Each	each	DT
cord-321868-xk4yuibj	87	2	minimal	minimal	JJ
cord-321868-xk4yuibj	87	3	region	region	NN
cord-321868-xk4yuibj	87	4	was	be	VBD
cord-321868-xk4yuibj	87	5	flanked	flank	VBN
cord-321868-xk4yuibj	87	6	by	by	IN
cord-321868-xk4yuibj	87	7	termination	termination	NN
cord-321868-xk4yuibj	87	8	codons	codon	NNS
cord-321868-xk4yuibj	87	9	to	to	TO
cord-321868-xk4yuibj	87	10	ensure	ensure	VB
cord-321868-xk4yuibj	87	11	that	that	IN
cord-321868-xk4yuibj	87	12	any	any	DT
cord-321868-xk4yuibj	87	13	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	87	14	that	that	WDT
cord-321868-xk4yuibj	87	15	occurred	occur	VBD
cord-321868-xk4yuibj	87	16	was	be	VBD
cord-321868-xk4yuibj	87	17	taking	take	VBG
cord-321868-xk4yuibj	87	18	place	place	NN
cord-321868-xk4yuibj	87	19	within	within	IN
cord-321868-xk4yuibj	87	20	the	the	DT
cord-321868-xk4yuibj	87	21	minimal	minimal	JJ
cord-321868-xk4yuibj	87	22	sequence	sequence	NN
cord-321868-xk4yuibj	87	23	.	.	.
cord-321868-xk4yuibj	88	1	These	these	DT
cord-321868-xk4yuibj	88	2	constructions	construction	NNS
cord-321868-xk4yuibj	88	3	were	be	VBD
cord-321868-xk4yuibj	88	4	introduced	introduce	VBN
cord-321868-xk4yuibj	88	5	into	into	IN
cord-321868-xk4yuibj	88	6	yeast	yeast	NN
cord-321868-xk4yuibj	88	7	and	and	CC
cord-321868-xk4yuibj	88	8	assayed	assay	VBN
cord-321868-xk4yuibj	88	9	for	for	IN
cord-321868-xk4yuibj	88	10	in	in	IN
cord-321868-xk4yuibj	88	11	vivo	vivo	NN
cord-321868-xk4yuibj	88	12	expression	expression	NN
cord-321868-xk4yuibj	88	13	of	of	IN
cord-321868-xk4yuibj	88	14	8-galactosidase	8-galactosidase	CD
cord-321868-xk4yuibj	88	15	.	.	.
cord-321868-xk4yuibj	89	1	In	in	IN
cord-321868-xk4yuibj	89	2	three	three	CD
cord-321868-xk4yuibj	89	3	of	of	IN
cord-321868-xk4yuibj	89	4	the	the	DT
cord-321868-xk4yuibj	89	5	plasmids	plasmid	NNS
cord-321868-xk4yuibj	89	6	(	(	-LRB-
cord-321868-xk4yuibj	89	7	pMB38-(O)fus	pMB38-(O)fus	NNP
cord-321868-xk4yuibj	89	8	,	,	,
cord-321868-xk4yuibj	89	9	pMB38-(+l)fus	pmb38-(+l)fus	CD
cord-321868-xk4yuibj	89	10	,	,	,
cord-321868-xk4yuibj	89	11	and	and	CC
cord-321868-xk4yuibj	89	12	pMB38-(-l)fus	pMB38-(-l)fus	NNPS
cord-321868-xk4yuibj	89	13	)	)	-RRB-
cord-321868-xk4yuibj	89	14	,	,	,
cord-321868-xk4yuibj	89	15	the	the	DT
cord-321868-xk4yuibj	89	16	HIS4A	HIS4A	NNP
cord-321868-xk4yuibj	89	17	and	and	CC
cord-321868-xk4yuibj	89	18	/acZ	/acZ	NNP
cord-321868-xk4yuibj	89	19	translational	translational	JJ
cord-321868-xk4yuibj	89	20	frames	frame	NNS
cord-321868-xk4yuibj	89	21	are	be	VBP
cord-321868-xk4yuibj	89	22	fused	fuse	VBN
cord-321868-xk4yuibj	89	23	.	.	.
cord-321868-xk4yuibj	90	1	Two	two	CD
cord-321868-xk4yuibj	90	2	of	of	IN
cord-321868-xk4yuibj	90	3	these	these	DT
cord-321868-xk4yuibj	90	4	constructions	construction	NNS
cord-321868-xk4yuibj	90	5	give	give	VBP
cord-321868-xk4yuibj	90	6	high	high	JJ
cord-321868-xk4yuibj	90	7	levels	level	NNS
cord-321868-xk4yuibj	90	8	of	of	IN
cord-321868-xk4yuibj	90	9	6-galactosidase	6-galactosidase	CD
cord-321868-xk4yuibj	90	10	activity	activity	NN
cord-321868-xk4yuibj	90	11	(	(	-LRB-
cord-321868-xk4yuibj	90	12	-3000	-3000	.
cord-321868-xk4yuibj	90	13	U	U	NNP
cord-321868-xk4yuibj	90	14	;	;	:
cord-321868-xk4yuibj	90	15	Table	table	NN
cord-321868-xk4yuibj	90	16	l	l	NNP
cord-321868-xk4yuibj	90	17	)	)	-RRB-
cord-321868-xk4yuibj	90	18	,	,	,
cord-321868-xk4yuibj	90	19	but	but	CC
cord-321868-xk4yuibj	90	20	the	the	DT
cord-321868-xk4yuibj	90	21	construction	construction	NN
cord-321868-xk4yuibj	90	22	in	in	IN
cord-321868-xk4yuibj	90	23	which	which	WDT
cord-321868-xk4yuibj	90	24	translation	translation	NN
cord-321868-xk4yuibj	90	25	occurs	occur	VBZ
cord-321868-xk4yuibj	90	26	in	in	IN
cord-321868-xk4yuibj	90	27	the	the	DT
cord-321868-xk4yuibj	90	28	-1	-1	JJ
cord-321868-xk4yuibj	90	29	frame	frame	NN
cord-321868-xk4yuibj	90	30	of	of	IN
cord-321868-xk4yuibj	90	31	the	the	DT
cord-321868-xk4yuibj	90	32	minimal	minimal	JJ
cord-321868-xk4yuibj	90	33	region	region	NN
cord-321868-xk4yuibj	90	34	expresses	express	VBZ
cord-321868-xk4yuibj	90	35	about	about	IN
cord-321868-xk4yuibj	90	36	50-fold	50-fold	JJ
cord-321868-xk4yuibj	90	37	lower	low	JJR
cord-321868-xk4yuibj	90	38	amounts	amount	NNS
cord-321868-xk4yuibj	90	39	.	.	.
cord-321868-xk4yuibj	91	1	The	the	DT
cord-321868-xk4yuibj	91	2	latter	latter	JJ
cord-321868-xk4yuibj	91	3	construction	construction	NN
cord-321868-xk4yuibj	91	4	has	have	VBZ
cord-321868-xk4yuibj	91	5	an	an	DT
cord-321868-xk4yuibj	91	6	in	in	IN
cord-321868-xk4yuibj	91	7	-	-	HYPH
cord-321868-xk4yuibj	91	8	frame	frame	NN
cord-321868-xk4yuibj	91	9	UAG	UAG	NNP
cord-321868-xk4yuibj	91	10	termination	termination	NN
cord-321868-xk4yuibj	91	11	codon	codon	NN
cord-321868-xk4yuibj	91	12	partway	partway	RB
cord-321868-xk4yuibj	91	13	through	through	IN
cord-321868-xk4yuibj	91	14	the	the	DT
cord-321868-xk4yuibj	91	15	frameshift	frameshift	NN
cord-321868-xk4yuibj	91	16	region	region	NN
cord-321868-xk4yuibj	91	17	,	,	,
cord-321868-xk4yuibj	91	18	and	and	CC
cord-321868-xk4yuibj	91	19	thus	thus	RB
cord-321868-xk4yuibj	91	20	translation	translation	NN
cord-321868-xk4yuibj	91	21	terminates	terminate	VBZ
cord-321868-xk4yuibj	91	22	prematurely	prematurely	RB
cord-321868-xk4yuibj	91	23	.	.	.
cord-321868-xk4yuibj	92	1	Two	two	CD
cord-321868-xk4yuibj	92	2	-1	-1	CD
cord-321868-xk4yuibj	92	3	frameshift	frameshift	NN
cord-321868-xk4yuibj	92	4	reporter	reporter	NN
cord-321868-xk4yuibj	92	5	constructs	construct	NNS
cord-321868-xk4yuibj	92	6	(	(	-LRB-
cord-321868-xk4yuibj	92	7	pMB38-(0)-l	pMB38-(0)-l	NNP
cord-321868-xk4yuibj	92	8	,	,	,
cord-321868-xk4yuibj	92	9	and	and	CC
cord-321868-xk4yuibj	93	1	pMB38-(+l)O	pmb38-(+l)o	LS
cord-321868-xk4yuibj	93	2	)	)	-RRB-
cord-321868-xk4yuibj	94	1	do	do	VBP
cord-321868-xk4yuibj	94	2	not	not	RB
cord-321868-xk4yuibj	94	3	express	express	VB
cord-321868-xk4yuibj	94	4	significant	significant	JJ
cord-321868-xk4yuibj	94	5	amounts	amount	NNS
cord-321868-xk4yuibj	94	6	of	of	IN
cord-321868-xk4yuibj	94	7	6-galactosidase	6-galactosidase	CD
cord-321868-xk4yuibj	94	8	.	.	.
cord-321868-xk4yuibj	95	1	We	-PRON-	PRP
cord-321868-xk4yuibj	95	2	conclude	conclude	VBP
cord-321868-xk4yuibj	95	3	that	that	IN
cord-321868-xk4yuibj	95	4	-1	-1	NNP
cord-321868-xk4yuibj	95	5	frameshifts	frameshift	NNS
cord-321868-xk4yuibj	95	6	do	do	VBP
cord-321868-xk4yuibj	95	7	not	not	RB
cord-321868-xk4yuibj	95	8	occur	occur	VB
cord-321868-xk4yuibj	95	9	from	from	IN
cord-321868-xk4yuibj	95	10	either	either	CC
cord-321868-xk4yuibj	95	11	the	the	DT
cord-321868-xk4yuibj	95	12	0	0	CD
cord-321868-xk4yuibj	95	13	(	(	-LRB-
cord-321868-xk4yuibj	95	14	defined	define	VBN
cord-321868-xk4yuibj	95	15	as	as	IN
cord-321868-xk4yuibj	95	16	the	the	DT
cord-321868-xk4yuibj	95	17	wild	wild	JJ
cord-321868-xk4yuibj	95	18	-	-	HYPH
cord-321868-xk4yuibj	95	19	type	type	NN
cord-321868-xk4yuibj	95	20	or	or	CC
cord-321868-xk4yuibj	95	21	NA	NA	NNP
cord-321868-xk4yuibj	95	22	reading	reading	NN
cord-321868-xk4yuibj	95	23	frame	frame	NN
cord-321868-xk4yuibj	95	24	)	)	-RRB-
cord-321868-xk4yuibj	95	25	or	or	CC
cord-321868-xk4yuibj	95	26	+	+	CC
cord-321868-xk4yuibj	95	27	l	l	NN
cord-321868-xk4yuibj	95	28	reading	reading	NN
cord-321868-xk4yuibj	95	29	frame	frame	NN
cord-321868-xk4yuibj	95	30	.	.	.
cord-321868-xk4yuibj	96	1	By	by	IN
cord-321868-xk4yuibj	96	2	contrast	contrast	NN
cord-321868-xk4yuibj	96	3	,	,	,
cord-321868-xk4yuibj	96	4	construct	construct	VB
cord-321868-xk4yuibj	96	5	pMB-38-(O)+l	pmb-38-(o)+l	NN
cord-321868-xk4yuibj	96	6	,	,	,
cord-321868-xk4yuibj	96	7	in	in	IN
cord-321868-xk4yuibj	96	8	which	which	WDT
cord-321868-xk4yuibj	96	9	translation	translation	NN
cord-321868-xk4yuibj	96	10	enters	enter	VBZ
cord-321868-xk4yuibj	96	11	the	the	DT
cord-321868-xk4yuibj	96	12	minimal	minimal	JJ
cord-321868-xk4yuibj	96	13	region	region	NN
cord-321868-xk4yuibj	96	14	in	in	IN
cord-321868-xk4yuibj	96	15	the	the	DT
cord-321868-xk4yuibj	96	16	0	0	CD
cord-321868-xk4yuibj	96	17	frame	frame	NN
cord-321868-xk4yuibj	96	18	(	(	-LRB-
cord-321868-xk4yuibj	96	19	TYA	TYA	NNP
cord-321868-xk4yuibj	96	20	)	)	-RRB-
cord-321868-xk4yuibj	96	21	and	and	CC
cord-321868-xk4yuibj	96	22	exits	exit	VBZ
cord-321868-xk4yuibj	96	23	in	in	IN
cord-321868-xk4yuibj	96	24	the	the	DT
cord-321868-xk4yuibj	96	25	+	+	SYM
cord-321868-xk4yuibj	96	26	l	l	NN
cord-321868-xk4yuibj	96	27	frame	frame	NN
cord-321868-xk4yuibj	96	28	(	(	-LRB-
cord-321868-xk4yuibj	96	29	p	p	NN
cord-321868-xk4yuibj	96	30	/	/	SYM
cord-321868-xk4yuibj	96	31	B	B	NNP
cord-321868-xk4yuibj	96	32	)	)	-RRB-
cord-321868-xk4yuibj	96	33	,	,	,
cord-321868-xk4yuibj	96	34	expresses	express	VBZ
cord-321868-xk4yuibj	96	35	high	high	JJ
cord-321868-xk4yuibj	96	36	levels	level	NNS
cord-321868-xk4yuibj	96	37	of	of	IN
cord-321868-xk4yuibj	96	38	8-galactosidase	8-galactosidase	CD
cord-321868-xk4yuibj	96	39	activity	activity	NN
cord-321868-xk4yuibj	96	40	,	,	,
cord-321868-xk4yuibj	96	41	indicating	indicate	VBG
cord-321868-xk4yuibj	96	42	about	about	RB
cord-321868-xk4yuibj	96	43	38	38	CD
cord-321868-xk4yuibj	96	44	%	%	NN
cord-321868-xk4yuibj	96	45	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	96	46	as	as	IN
cord-321868-xk4yuibj	96	47	expected	expect	VBN
cord-321868-xk4yuibj	96	48	.	.	.
cord-321868-xk4yuibj	97	1	Frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	97	2	from	from	IN
cord-321868-xk4yuibj	97	3	the	the	DT
cord-321868-xk4yuibj	97	4	+	+	CC
cord-321868-xk4yuibj	97	5	l	l	NN
cord-321868-xk4yuibj	97	6	reading	reading	NN
cord-321868-xk4yuibj	97	7	frame	frame	NN
cord-321868-xk4yuibj	97	8	to	to	IN
cord-321868-xk4yuibj	97	9	the	the	DT
cord-321868-xk4yuibj	97	10	-1	-1	NN
cord-321868-xk4yuibj	97	11	reading	reading	NN
cord-321868-xk4yuibj	97	12	frame	frame	NN
cord-321868-xk4yuibj	97	13	(	(	-LRB-
cord-321868-xk4yuibj	97	14	pMB38-(+1)-l	pmb38-(+1)-l	NN
cord-321868-xk4yuibj	97	15	)	)	-RRB-
cord-321868-xk4yuibj	97	16	shows	show	VBZ
cord-321868-xk4yuibj	97	17	insignificant	insignificant	JJ
cord-321868-xk4yuibj	97	18	enzyme	enzyme	NN
cord-321868-xk4yuibj	97	19	activity	activity	NN
cord-321868-xk4yuibj	97	20	,	,	,
cord-321868-xk4yuibj	97	21	indicating	indicate	VBG
cord-321868-xk4yuibj	97	22	that	that	IN
cord-321868-xk4yuibj	97	23	+1	+1	HYPH
cord-321868-xk4yuibj	97	24	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	97	25	does	do	VBZ
cord-321868-xk4yuibj	97	26	not	not	RB
cord-321868-xk4yuibj	97	27	occur	occur	VB
cord-321868-xk4yuibj	97	28	from	from	IN
cord-321868-xk4yuibj	97	29	the	the	DT
cord-321868-xk4yuibj	97	30	+	+	CC
cord-321868-xk4yuibj	97	31	l	l	NN
cord-321868-xk4yuibj	97	32	reading	reading	NN
cord-321868-xk4yuibj	97	33	frame	frame	NN
cord-321868-xk4yuibj	97	34	of	of	IN
cord-321868-xk4yuibj	97	35	the	the	DT
cord-321868-xk4yuibj	97	36	minimal	minimal	JJ
cord-321868-xk4yuibj	97	37	sequence	sequence	NN
cord-321868-xk4yuibj	97	38	.	.	.
cord-321868-xk4yuibj	98	1	To	to	TO
cord-321868-xk4yuibj	98	2	test	test	VB
cord-321868-xk4yuibj	98	3	if	if	IN
cord-321868-xk4yuibj	98	4	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	98	5	occurs	occur	VBZ
cord-321868-xk4yuibj	98	6	in	in	IN
cord-321868-xk4yuibj	98	7	the	the	DT
cord-321868-xk4yuibj	98	8	+	+	SYM
cord-321868-xk4yuibj	98	9	l	l	NN
cord-321868-xk4yuibj	98	10	or	or	CC
cord-321868-xk4yuibj	98	11	-1	-1	JJ
cord-321868-xk4yuibj	98	12	direction	direction	NN
cord-321868-xk4yuibj	98	13	from	from	IN
cord-321868-xk4yuibj	98	14	the	the	DT
cord-321868-xk4yuibj	98	15	-1	-1	NN
cord-321868-xk4yuibj	98	16	reading	reading	NN
cord-321868-xk4yuibj	98	17	frame	frame	NN
cord-321868-xk4yuibj	98	18	,	,	,
cord-321868-xk4yuibj	98	19	we	-PRON-	PRP
cord-321868-xk4yuibj	98	20	transformed	transform	VBD
cord-321868-xk4yuibj	98	21	an	an	DT
cord-321868-xk4yuibj	98	22	amber	amber	NN
cord-321868-xk4yuibj	98	23	suppressor	suppressor	NN
cord-321868-xk4yuibj	98	24	strain	strain	NN
cord-321868-xk4yuibj	98	25	,	,	,
cord-321868-xk4yuibj	98	26	L0861	L0861	NNP
cord-321868-xk4yuibj	98	27	,	,	,
cord-321868-xk4yuibj	98	28	to	to	TO
cord-321868-xk4yuibj	98	29	allow	allow	VB
cord-321868-xk4yuibj	98	30	readthrough	readthrough	NN
cord-321868-xk4yuibj	98	31	past	past	IN
cord-321868-xk4yuibj	98	32	the	the	DT
cord-321868-xk4yuibj	98	33	in	in	IN
cord-321868-xk4yuibj	98	34	-	-	HYPH
cord-321868-xk4yuibj	98	35	frame	frame	NN
cord-321868-xk4yuibj	98	36	UAG	UAG	NNP
cord-321868-xk4yuibj	98	37	.	.	.
cord-321868-xk4yuibj	99	1	In	in	IN
cord-321868-xk4yuibj	99	2	this	this	DT
cord-321868-xk4yuibj	99	3	background	background	NN
cord-321868-xk4yuibj	99	4	,	,	,
cord-321868-xk4yuibj	99	5	the	the	DT
cord-321868-xk4yuibj	99	6	p	p	NN
cord-321868-xk4yuibj	99	7	/	/	SYM
cord-321868-xk4yuibj	99	8	A	A	NNP
cord-321868-xk4yuibj	99	9	-	-	HYPH
cord-321868-xk4yuibj	99	10	N	N	NNP
cord-321868-xk4yuibj	99	11	/	/	SYM
cord-321868-xk4yuibj	99	12	B	b	NN
cord-321868-xk4yuibj	99	13	+	+	CC
cord-321868-xk4yuibj	99	14	l	l	NN
cord-321868-xk4yuibj	99	15	frameshift	frameshift	NN
cord-321868-xk4yuibj	99	16	reporter	reporter	NN
cord-321868-xk4yuibj	99	17	plasmid	plasmid	NN
cord-321868-xk4yuibj	99	18	,	,	,
cord-321868-xk4yuibj	99	19	pMB38-(0)+1	pMB38-(0)+1	NNP
cord-321868-xk4yuibj	99	20	,	,	,
cord-321868-xk4yuibj	99	21	promotes	promote	VBZ
cord-321868-xk4yuibj	99	22	about	about	IN
cord-321868-xk4yuibj	99	23	48	48	CD
cord-321868-xk4yuibj	99	24	%	%	NN
cord-321868-xk4yuibj	99	25	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	99	26	(	(	-LRB-
cord-321868-xk4yuibj	99	27	Table	table	NN
cord-321868-xk4yuibj	99	28	1	1	CD
cord-321868-xk4yuibj	99	29	)	)	-RRB-
cord-321868-xk4yuibj	99	30	.	.	.
cord-321868-xk4yuibj	100	1	Frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	100	2	in	in	IN
cord-321868-xk4yuibj	100	3	the	the	DT
cord-321868-xk4yuibj	100	4	+	+	CC
cord-321868-xk4yuibj	100	5	l	l	NN
cord-321868-xk4yuibj	100	6	direction	direction	NN
cord-321868-xk4yuibj	100	7	from	from	IN
cord-321868-xk4yuibj	100	8	the	the	DT
cord-321868-xk4yuibj	100	9	other	other	JJ
cord-321868-xk4yuibj	100	10	two	two	CD
cord-321868-xk4yuibj	100	11	reading	read	VBG
cord-321868-xk4yuibj	100	12	frames	frame	NNS
cord-321868-xk4yuibj	100	13	is	be	VBZ
cord-321868-xk4yuibj	100	14	not	not	RB
cord-321868-xk4yuibj	100	15	seen	see	VBN
cord-321868-xk4yuibj	100	16	.	.	.
cord-321868-xk4yuibj	101	1	Likewise	likewise	RB
cord-321868-xk4yuibj	101	2	,	,	,
cord-321868-xk4yuibj	101	3	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	101	4	in	in	IN
cord-321868-xk4yuibj	101	5	the	the	DT
cord-321868-xk4yuibj	101	6	-1	-1	JJ
cord-321868-xk4yuibj	101	7	direction	direction	NN
cord-321868-xk4yuibj	101	8	does	do	VBZ
cord-321868-xk4yuibj	101	9	not	not	RB
cord-321868-xk4yuibj	101	10	occur	occur	VB
cord-321868-xk4yuibj	101	11	from	from	IN
cord-321868-xk4yuibj	101	12	any	any	DT
cord-321868-xk4yuibj	101	13	of	of	IN
cord-321868-xk4yuibj	101	14	the	the	DT
cord-321868-xk4yuibj	101	15	reading	reading	NN
cord-321868-xk4yuibj	101	16	frames	frame	NNS
cord-321868-xk4yuibj	101	17	.	.	.
cord-321868-xk4yuibj	102	1	We	-PRON-	PRP
cord-321868-xk4yuibj	102	2	conclude	conclude	VBP
cord-321868-xk4yuibj	102	3	from	from	IN
cord-321868-xk4yuibj	102	4	these	these	DT
cord-321868-xk4yuibj	102	5	results	result	NNS
cord-321868-xk4yuibj	102	6	that	that	WDT
cord-321868-xk4yuibj	102	7	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	102	8	in	in	IN
cord-321868-xk4yuibj	102	9	the	the	DT
cord-321868-xk4yuibj	102	10	14	14	CD
cord-321868-xk4yuibj	102	11	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	102	12	minimal	minimal	JJ
cord-321868-xk4yuibj	102	13	region	region	NN
cord-321868-xk4yuibj	102	14	occurs	occur	VBZ
cord-321868-xk4yuibj	102	15	only	only	RB
cord-321868-xk4yuibj	102	16	in	in	IN
cord-321868-xk4yuibj	102	17	the	the	DT
cord-321868-xk4yuibj	102	18	+	+	CC
cord-321868-xk4yuibj	102	19	l	l	NN
cord-321868-xk4yuibj	102	20	direction	direction	NN
cord-321868-xk4yuibj	102	21	and	and	CC
cord-321868-xk4yuibj	102	22	only	only	RB
cord-321868-xk4yuibj	102	23	from	from	IN
cord-321868-xk4yuibj	102	24	the	the	DT
cord-321868-xk4yuibj	102	25	0	0	CD
cord-321868-xk4yuibj	102	26	,	,	,
cord-321868-xk4yuibj	102	27	or	or	CC
cord-321868-xk4yuibj	102	28	TYA	TYA	NNP
cord-321868-xk4yuibj	102	29	,	,	,
cord-321868-xk4yuibj	102	30	reading	read	VBG
cord-321868-xk4yuibj	102	31	frame	frame	NN
cord-321868-xk4yuibj	102	32	.	.	.
cord-321868-xk4yuibj	103	1	Sequence	sequence	NN
cord-321868-xk4yuibj	104	1	To	to	TO
cord-321868-xk4yuibj	104	2	determine	determine	VB
cord-321868-xk4yuibj	104	3	whether	whether	IN
cord-321868-xk4yuibj	104	4	all	all	DT
cord-321868-xk4yuibj	104	5	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	104	6	of	of	IN
cord-321868-xk4yuibj	104	7	the	the	DT
cord-321868-xk4yuibj	104	8	14	14	CD
cord-321868-xk4yuibj	104	9	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	104	10	frameshift	frameshift	NN
cord-321868-xk4yuibj	104	11	site	site	NN
cord-321868-xk4yuibj	104	12	are	be	VBP
cord-321868-xk4yuibj	104	13	required	require	VBN
cord-321868-xk4yuibj	104	14	for	for	IN
cord-321868-xk4yuibj	104	15	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	104	16	,	,	,
cord-321868-xk4yuibj	104	17	a	a	DT
cord-321868-xk4yuibj	104	18	series	series	NN
cord-321868-xk4yuibj	104	19	of	of	IN
cord-321868-xk4yuibj	104	20	frameshift	frameshift	NN
cord-321868-xk4yuibj	104	21	reporter	reporter	NN
cord-321868-xk4yuibj	104	22	constructs	construct	NNS
cord-321868-xk4yuibj	104	23	retaining	retain	VBG
cord-321868-xk4yuibj	104	24	increasingly	increasingly	RB
cord-321868-xk4yuibj	104	25	smaller	small	JJR
cord-321868-xk4yuibj	104	26	portions	portion	NNS
cord-321868-xk4yuibj	104	27	of	of	IN
cord-321868-xk4yuibj	104	28	the	the	DT
cord-321868-xk4yuibj	104	29	minimal	minimal	JJ
cord-321868-xk4yuibj	104	30	sequence	sequence	NN
cord-321868-xk4yuibj	104	31	were	be	VBD
cord-321868-xk4yuibj	104	32	made	make	VBN
cord-321868-xk4yuibj	104	33	by	by	IN
cord-321868-xk4yuibj	104	34	synthesizing	synthesize	VBG
cord-321868-xk4yuibj	104	35	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	104	36	that	that	WDT
cord-321868-xk4yuibj	104	37	differ	differ	VBP
cord-321868-xk4yuibj	104	38	in	in	IN
cord-321868-xk4yuibj	104	39	length	length	NN
cord-321868-xk4yuibj	104	40	by	by	IN
cord-321868-xk4yuibj	104	41	sin	sin	NN
cord-321868-xk4yuibj	104	42	-	-	HYPH
cord-321868-xk4yuibj	104	43	gle	gle	NNP
cord-321868-xk4yuibj	104	44	codons	codon	NNS
cord-321868-xk4yuibj	104	45	of	of	IN
cord-321868-xk4yuibj	104	46	the	the	DT
cord-321868-xk4yuibj	104	47	TYA	TYA	NNP
cord-321868-xk4yuibj	104	48	reading	reading	NN
cord-321868-xk4yuibj	104	49	frame	frame	NN
cord-321868-xk4yuibj	104	50	.	.	.
cord-321868-xk4yuibj	105	1	The	the	DT
cord-321868-xk4yuibj	105	2	remaining	remain	VBG
cord-321868-xk4yuibj	105	3	sequences	sequence	NNS
cord-321868-xk4yuibj	105	4	in	in	IN
cord-321868-xk4yuibj	105	5	each	each	DT
cord-321868-xk4yuibj	105	6	oligonucleotide	oligonucleotide	JJ
cord-321868-xk4yuibj	105	7	were	be	VBD
cord-321868-xk4yuibj	105	8	flanked	flank	VBN
cord-321868-xk4yuibj	105	9	by	by	IN
cord-321868-xk4yuibj	105	10	termination	termination	NN
cord-321868-xk4yuibj	105	11	codons	codon	NNS
cord-321868-xk4yuibj	105	12	to	to	TO
cord-321868-xk4yuibj	105	13	ensure	ensure	VB
cord-321868-xk4yuibj	105	14	that	that	IN
cord-321868-xk4yuibj	105	15	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	105	16	occurs	occur	VBZ
cord-321868-xk4yuibj	105	17	only	only	RB
cord-321868-xk4yuibj	105	18	within	within	IN
cord-321868-xk4yuibj	105	19	the	the	DT
cord-321868-xk4yuibj	105	20	sequence	sequence	NN
cord-321868-xk4yuibj	105	21	.	.	.
cord-321868-xk4yuibj	106	1	The	the	DT
cord-321868-xk4yuibj	106	2	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	106	3	were	be	VBD
cord-321868-xk4yuibj	106	4	inserted	insert	VBN
cord-321868-xk4yuibj	106	5	into	into	IN
cord-321868-xk4yuibj	106	6	the	the	DT
cord-321868-xk4yuibj	106	7	H	H	NNP
cord-321868-xk4yuibj	106	8	/	/	SYM
cord-321868-xk4yuibj	106	9	SA::/acZframeshift	SA::/acZframeshift	NNP
cord-321868-xk4yuibj	106	10	reporter	reporter	NN
cord-321868-xk4yuibj	106	11	plasmid	plasmid	NN
cord-321868-xk4yuibj	106	12	pMB25	pmb25	XX
cord-321868-xk4yuibj	106	13	at	at	IN
cord-321868-xk4yuibj	106	14	the	the	DT
cord-321868-xk4yuibj	106	15	Bamlil	Bamlil	NNP
cord-321868-xk4yuibj	106	16	site	site	NN
cord-321868-xk4yuibj	106	17	as	as	IN
cord-321868-xk4yuibj	106	18	described	describe	VBN
cord-321868-xk4yuibj	106	19	in	in	IN
cord-321868-xk4yuibj	106	20	Experimental	Experimental	NNP
cord-321868-xk4yuibj	106	21	Procedures	procedure	NNS
cord-321868-xk4yuibj	106	22	.	.	.
cord-321868-xk4yuibj	107	1	Frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	107	2	in	in	IN
cord-321868-xk4yuibj	107	3	the	the	DT
cord-321868-xk4yuibj	107	4	+	+	CC
cord-321868-xk4yuibj	107	5	l	l	NN
cord-321868-xk4yuibj	107	6	direction	direction	NN
cord-321868-xk4yuibj	107	7	will	will	MD
cord-321868-xk4yuibj	107	8	result	result	VB
cord-321868-xk4yuibj	107	9	in	in	IN
cord-321868-xk4yuibj	107	10	8-galactosidase	8-galactosidase	CD
cord-321868-xk4yuibj	107	11	production	production	NN
cord-321868-xk4yuibj	107	12	from	from	IN
cord-321868-xk4yuibj	107	13	the	the	DT
cord-321868-xk4yuibj	107	14	/acZ	/acZ	NNP
cord-321868-xk4yuibj	107	15	gene	gene	NN
cord-321868-xk4yuibj	107	16	.	.	.
cord-321868-xk4yuibj	108	1	Table	table	NN
cord-321868-xk4yuibj	108	2	2	2	CD
cord-321868-xk4yuibj	108	3	shows	show	VBZ
cord-321868-xk4yuibj	108	4	the	the	DT
cord-321868-xk4yuibj	108	5	sequence	sequence	NN
cord-321868-xk4yuibj	108	6	of	of	IN
cord-321868-xk4yuibj	108	7	the	the	DT
cord-321868-xk4yuibj	108	8	deletion	deletion	NN
cord-321868-xk4yuibj	108	9	constructs	construct	VBZ
cord-321868-xk4yuibj	108	10	as	as	RB
cord-321868-xk4yuibj	108	11	well	well	RB
cord-321868-xk4yuibj	108	12	as	as	IN
cord-321868-xk4yuibj	108	13	the	the	DT
cord-321868-xk4yuibj	108	14	results	result	NNS
cord-321868-xk4yuibj	108	15	from	from	IN
cord-321868-xk4yuibj	108	16	each	each	DT
cord-321868-xk4yuibj	108	17	construct	construct	NN
cord-321868-xk4yuibj	108	18	.	.	.
cord-321868-xk4yuibj	109	1	Deleting	delete	VBG
cord-321868-xk4yuibj	109	2	the	the	DT
cord-321868-xk4yuibj	109	3	first	first	JJ
cord-321868-xk4yuibj	109	4	two	two	CD
cord-321868-xk4yuibj	109	5	codons	codon	NNS
cord-321868-xk4yuibj	109	6	from	from	IN
cord-321868-xk4yuibj	109	7	the	the	DT
cord-321868-xk4yuibj	109	8	3	3	CD
cord-321868-xk4yuibj	109	9	'	'	NN
cord-321868-xk4yuibj	109	10	end	end	NN
cord-321868-xk4yuibj	109	11	of	of	IN
cord-321868-xk4yuibj	109	12	the	the	DT
cord-321868-xk4yuibj	109	13	14	14	CD
cord-321868-xk4yuibj	109	14	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	109	15	sequence	sequence	NN
cord-321868-xk4yuibj	109	16	(	(	-LRB-
cord-321868-xk4yuibj	109	17	including	include	VBG
cord-321868-xk4yuibj	109	18	5	5	CD
cord-321868-xk4yuibj	109	19	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	109	20	of	of	IN
cord-321868-xk4yuibj	109	21	the	the	DT
cord-321868-xk4yuibj	109	22	14	14	CD
cord-321868-xk4yuibj	109	23	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	109	24	sequence	sequence	NN
cord-321868-xk4yuibj	109	25	)	)	-RRB-
cord-321868-xk4yuibj	109	26	has	have	VBZ
cord-321868-xk4yuibj	109	27	no	no	DT
cord-321868-xk4yuibj	109	28	effect	effect	NN
cord-321868-xk4yuibj	109	29	on	on	IN
cord-321868-xk4yuibj	109	30	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	109	31	,	,	,
cord-321868-xk4yuibj	109	32	demonstrating	demonstrate	VBG
cord-321868-xk4yuibj	109	33	that	that	IN
cord-321868-xk4yuibj	109	34	only	only	RB
cord-321868-xk4yuibj	109	35	three	three	CD
cord-321868-xk4yuibj	109	36	codons	codon	NNS
cord-321868-xk4yuibj	109	37	from	from	IN
cord-321868-xk4yuibj	109	38	the	the	DT
cord-321868-xk4yuibj	109	39	14	14	CD
cord-321868-xk4yuibj	109	40	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	109	41	sequence	sequence	NN
cord-321868-xk4yuibj	109	42	are	be	VBP
cord-321868-xk4yuibj	109	43	necessary	necessary	JJ
cord-321868-xk4yuibj	109	44	to	to	TO
cord-321868-xk4yuibj	109	45	direct	direct	VB
cord-321868-xk4yuibj	109	46	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	109	47	.	.	.
cord-321868-xk4yuibj	110	1	No	no	DT
cord-321868-xk4yuibj	110	2	other	other	JJ
cord-321868-xk4yuibj	110	3	Ty	ty	NN
cord-321868-xk4yuibj	110	4	-	-	HYPH
cord-321868-xk4yuibj	110	5	derived	derive	VBN
cord-321868-xk4yuibj	110	6	sequences	sequence	NNS
cord-321868-xk4yuibj	110	7	are	be	VBP
cord-321868-xk4yuibj	110	8	present	present	JJ
cord-321868-xk4yuibj	110	9	,	,	,
cord-321868-xk4yuibj	110	10	yet	yet	CC
cord-321868-xk4yuibj	110	11	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	110	12	is	be	VBZ
cord-321868-xk4yuibj	110	13	occurring	occur	VBG
cord-321868-xk4yuibj	110	14	at	at	IN
cord-321868-xk4yuibj	110	15	wild	wild	JJ
cord-321868-xk4yuibj	110	16	-	-	HYPH
cord-321868-xk4yuibj	110	17	type	type	NN
cord-321868-xk4yuibj	110	18	levels	level	NNS
cord-321868-xk4yuibj	110	19	.	.	.
cord-321868-xk4yuibj	111	1	Deletion	deletion	NN
cord-321868-xk4yuibj	111	2	of	of	IN
cord-321868-xk4yuibj	111	3	an	an	DT
cord-321868-xk4yuibj	111	4	additional	additional	JJ
cord-321868-xk4yuibj	111	5	codon	codon	NN
cord-321868-xk4yuibj	111	6	from	from	IN
cord-321868-xk4yuibj	111	7	the	the	DT
cord-321868-xk4yuibj	111	8	3	3	CD
cord-321868-xk4yuibj	111	9	'	'	NN
cord-321868-xk4yuibj	111	10	end	end	NN
cord-321868-xk4yuibj	111	11	or	or	CC
cord-321868-xk4yuibj	111	12	deletion	deletion	NN
cord-321868-xk4yuibj	111	13	of	of	IN
cord-321868-xk4yuibj	111	14	one	one	CD
cord-321868-xk4yuibj	111	15	or	or	CC
cord-321868-xk4yuibj	111	16	two	two	CD
cord-321868-xk4yuibj	111	17	codons	codon	NNS
cord-321868-xk4yuibj	111	18	from	from	IN
cord-321868-xk4yuibj	111	19	the	the	DT
cord-321868-xk4yuibj	111	20	5	5	CD
cord-321868-xk4yuibj	111	21	'	'	POS
cord-321868-xk4yuibj	111	22	end	end	NN
cord-321868-xk4yuibj	111	23	results	result	NNS
cord-321868-xk4yuibj	111	24	in	in	IN
cord-321868-xk4yuibj	111	25	a	a	DT
cord-321868-xk4yuibj	111	26	much	much	RB
cord-321868-xk4yuibj	111	27	lower	low	JJR
cord-321868-xk4yuibj	111	28	frequency	frequency	NN
cord-321868-xk4yuibj	111	29	of	of	IN
cord-321868-xk4yuibj	111	30	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	112	1	(	(	-LRB-
cord-321868-xk4yuibj	112	2	Table	table	NN
cord-321868-xk4yuibj	112	3	 	 	_SP
cord-321868-xk4yuibj	112	4	2	2	CD
cord-321868-xk4yuibj	112	5	)	)	-RRB-
cord-321868-xk4yuibj	112	6	.	.	.
cord-321868-xk4yuibj	113	1	All	all	DT
cord-321868-xk4yuibj	113	2	three	three	CD
cord-321868-xk4yuibj	113	3	constructs	construct	NNS
cord-321868-xk4yuibj	113	4	are	be	VBP
cord-321868-xk4yuibj	113	5	at	at	IN
cord-321868-xk4yuibj	113	6	least	least	JJS
cord-321868-xk4yuibj	113	7	40-fold	40-fold	CD
cord-321868-xk4yuibj	113	8	lower	low	JJR
cord-321868-xk4yuibj	113	9	in	in	IN
cord-321868-xk4yuibj	113	10	expression	expression	NN
cord-321868-xk4yuibj	113	11	than	than	IN
cord-321868-xk4yuibj	113	12	the	the	DT
cord-321868-xk4yuibj	113	13	plasmid	plasmid	NN
cord-321868-xk4yuibj	113	14	retaining	retain	VBG
cord-321868-xk4yuibj	113	15	the	the	DT
cord-321868-xk4yuibj	113	16	first	first	JJ
cord-321868-xk4yuibj	113	17	three	three	CD
cord-321868-xk4yuibj	113	18	codons	codon	NNS
cord-321868-xk4yuibj	113	19	of	of	IN
cord-321868-xk4yuibj	113	20	the	the	DT
cord-321868-xk4yuibj	113	21	14	14	CD
cord-321868-xk4yuibj	113	22	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	113	23	sequence	sequence	NN
cord-321868-xk4yuibj	113	24	.	.	.
cord-321868-xk4yuibj	114	1	Since	since	IN
cord-321868-xk4yuibj	114	2	no	no	DT
cord-321868-xk4yuibj	114	3	construction	construction	NN
cord-321868-xk4yuibj	114	4	lacking	lack	VBG
cord-321868-xk4yuibj	114	5	any	any	DT
cord-321868-xk4yuibj	114	6	of	of	IN
cord-321868-xk4yuibj	114	7	the	the	DT
cord-321868-xk4yuibj	114	8	first	first	JJ
cord-321868-xk4yuibj	114	9	three	three	CD
cord-321868-xk4yuibj	114	10	codons	codon	NNS
cord-321868-xk4yuibj	114	11	expresses	express	VBZ
cord-321868-xk4yuibj	114	12	significant	significant	JJ
cord-321868-xk4yuibj	114	13	levels	level	NNS
cord-321868-xk4yuibj	114	14	of	of	IN
cord-321868-xk4yuibj	114	15	8-galactosidase	8-galactosidase	CD
cord-321868-xk4yuibj	114	16	,	,	,
cord-321868-xk4yuibj	114	17	we	-PRON-	PRP
cord-321868-xk4yuibj	114	18	conclude	conclude	VBP
cord-321868-xk4yuibj	114	19	that	that	IN
cord-321868-xk4yuibj	114	20	the	the	DT
cord-321868-xk4yuibj	114	21	first	first	JJ
cord-321868-xk4yuibj	114	22	three	three	CD
cord-321868-xk4yuibj	114	23	codons	codon	NNS
cord-321868-xk4yuibj	114	24	of	of	IN
cord-321868-xk4yuibj	114	25	the	the	DT
cord-321868-xk4yuibj	114	26	14	14	CD
cord-321868-xk4yuibj	114	27	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	114	28	sequence	sequence	NN
cord-321868-xk4yuibj	114	29	,	,	,
cord-321868-xk4yuibj	114	30	CUU	CUU	NNP
cord-321868-xk4yuibj	114	31	-	-	HYPH
cord-321868-xk4yuibj	114	32	AGG	AGG	NNP
cord-321868-xk4yuibj	114	33	-	-	HYPH
cord-321868-xk4yuibj	114	34	CCA	CCA	NNP
cord-321868-xk4yuibj	114	35	,	,	,
cord-321868-xk4yuibj	114	36	are	be	VBP
cord-321868-xk4yuibj	114	37	necessary	necessary	JJ
cord-321868-xk4yuibj	114	38	to	to	TO
cord-321868-xk4yuibj	114	39	direct	direct	VB
cord-321868-xk4yuibj	114	40	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	114	41	.	.	.
cord-321868-xk4yuibj	115	1	This	this	DT
cord-321868-xk4yuibj	115	2	does	do	VBZ
cord-321868-xk4yuibj	115	3	not	not	RB
cord-321868-xk4yuibj	115	4	mean	mean	VB
cord-321868-xk4yuibj	115	5	that	that	IN
cord-321868-xk4yuibj	115	6	each	each	DT
cord-321868-xk4yuibj	115	7	nucleotide	nucleotide	NN
cord-321868-xk4yuibj	115	8	is	be	VBZ
cord-321868-xk4yuibj	115	9	necessary	necessary	JJ
cord-321868-xk4yuibj	115	10	,	,	,
cord-321868-xk4yuibj	115	11	since	since	IN
cord-321868-xk4yuibj	115	12	the	the	DT
cord-321868-xk4yuibj	115	13	deletions	deletion	NNS
cord-321868-xk4yuibj	115	14	do	do	VBP
cord-321868-xk4yuibj	115	15	not	not	RB
cord-321868-xk4yuibj	115	16	allow	allow	VB
cord-321868-xk4yuibj	115	17	us	-PRON-	PRP
cord-321868-xk4yuibj	115	18	to	to	TO
cord-321868-xk4yuibj	115	19	map	map	VB
cord-321868-xk4yuibj	115	20	effects	effect	NNS
cord-321868-xk4yuibj	115	21	at	at	IN
cord-321868-xk4yuibj	115	22	a	a	DT
cord-321868-xk4yuibj	115	23	resolution	resolution	NN
cord-321868-xk4yuibj	115	24	of	of	IN
cord-321868-xk4yuibj	115	25	less	less	JJR
cord-321868-xk4yuibj	115	26	than	than	IN
cord-321868-xk4yuibj	115	27	one	one	CD
cord-321868-xk4yuibj	115	28	codon	codon	NN
cord-321868-xk4yuibj	115	29	.	.	.
cord-321868-xk4yuibj	115	30	 	 	_SP
cord-321868-xk4yuibj	116	1	Defines	define	VBZ
cord-321868-xk4yuibj	116	2	7	7	CD
cord-321868-xk4yuibj	116	3	Essential	essential	JJ
cord-321868-xk4yuibj	116	4	Nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	117	1	The	the	DT
cord-321868-xk4yuibj	117	2	deletion	deletion	NN
cord-321868-xk4yuibj	117	3	analysis	analysis	NN
cord-321868-xk4yuibj	117	4	described	describe	VBN
cord-321868-xk4yuibj	117	5	above	above	IN
cord-321868-xk4yuibj	117	6	crudely	crudely	RB
cord-321868-xk4yuibj	117	7	defines	define	VBZ
cord-321868-xk4yuibj	117	8	the	the	DT
cord-321868-xk4yuibj	117	9	sequence	sequence	NN
cord-321868-xk4yuibj	117	10	that	that	WDT
cord-321868-xk4yuibj	117	11	promotes	promote	VBZ
cord-321868-xk4yuibj	117	12	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	117	13	.	.	.
cord-321868-xk4yuibj	118	1	To	to	TO
cord-321868-xk4yuibj	118	2	define	define	VB
cord-321868-xk4yuibj	118	3	which	which	WDT
cord-321868-xk4yuibj	118	4	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	118	5	are	be	VBP
cord-321868-xk4yuibj	118	6	critical	critical	JJ
cord-321868-xk4yuibj	118	7	for	for	IN
cord-321868-xk4yuibj	118	8	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	118	9	,	,	,
cord-321868-xk4yuibj	118	10	we	-PRON-	PRP
cord-321868-xk4yuibj	118	11	synthesized	synthesize	VBD
cord-321868-xk4yuibj	118	12	a	a	DT
cord-321868-xk4yuibj	118	13	series	series	NN
cord-321868-xk4yuibj	118	14	of	of	IN
cord-321868-xk4yuibj	118	15	nine	nine	CD
cord-321868-xk4yuibj	118	16	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	118	17	.	.	.
cord-321868-xk4yuibj	119	1	Mixed	mixed	JJ
cord-321868-xk4yuibj	119	2	synthesis	synthesis	NN
cord-321868-xk4yuibj	119	3	was	be	VBD
cord-321868-xk4yuibj	119	4	done	do	VBN
cord-321868-xk4yuibj	119	5	with	with	IN
cord-321868-xk4yuibj	119	6	the	the	DT
cord-321868-xk4yuibj	119	7	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	119	8	corresponding	correspond	VBG
cord-321868-xk4yuibj	119	9	to	to	IN
cord-321868-xk4yuibj	119	10	the	the	DT
cord-321868-xk4yuibj	119	11	three	three	CD
cord-321868-xk4yuibj	119	12	desired	desire	VBN
cord-321868-xk4yuibj	119	13	mutations	mutation	NNS
cord-321868-xk4yuibj	119	14	at	at	IN
cord-321868-xk4yuibj	119	15	each	each	DT
cord-321868-xk4yuibj	119	16	position	position	NN
cord-321868-xk4yuibj	119	17	of	of	IN
cord-321868-xk4yuibj	119	18	the	the	DT
cord-321868-xk4yuibj	119	19	9	9	CD
cord-321868-xk4yuibj	119	20	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	119	21	minimal	minimal	JJ
cord-321868-xk4yuibj	119	22	sequence	sequence	NN
cord-321868-xk4yuibj	119	23	defined	define	VBN
cord-321868-xk4yuibj	119	24	above	above	RB
cord-321868-xk4yuibj	119	25	.	.	.
cord-321868-xk4yuibj	120	1	The	the	DT
cord-321868-xk4yuibj	120	2	three	three	CD
cord-321868-xk4yuibj	120	3	mutations	mutation	NNS
cord-321868-xk4yuibj	120	4	at	at	IN
cord-321868-xk4yuibj	120	5	each	each	DT
cord-321868-xk4yuibj	120	6	position	position	NN
cord-321868-xk4yuibj	120	7	were	be	VBD
cord-321868-xk4yuibj	120	8	tested	test	VBN
cord-321868-xk4yuibj	120	9	for	for	IN
cord-321868-xk4yuibj	120	10	their	-PRON-	PRP$
cord-321868-xk4yuibj	120	11	effect	effect	NN
cord-321868-xk4yuibj	120	12	on	on	IN
cord-321868-xk4yuibj	120	13	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	120	14	after	after	IN
cord-321868-xk4yuibj	120	15	cloning	clone	VBG
cord-321868-xk4yuibj	120	16	into	into	IN
cord-321868-xk4yuibj	120	17	the	the	DT
cord-321868-xk4yuibj	120	18	HIS4A::lacZframeshift	HIS4A::lacZframeshift	NNP
cord-321868-xk4yuibj	120	19	reporter	reporter	NN
cord-321868-xk4yuibj	120	20	plasmid	plasmid	NN
cord-321868-xk4yuibj	120	21	pMB38	pMB38	NNS
cord-321868-xk4yuibj	120	22	between	between	IN
cord-321868-xk4yuibj	120	23	the	the	DT
cord-321868-xk4yuibj	120	24	BamHl	BamHl	NNP
cord-321868-xk4yuibj	120	25	and	and	CC
cord-321868-xk4yuibj	120	26	Kpnl	Kpnl	NNP
cord-321868-xk4yuibj	120	27	sites	site	NNS
cord-321868-xk4yuibj	120	28	as	as	IN
cord-321868-xk4yuibj	120	29	described	describe	VBN
cord-321868-xk4yuibj	120	30	in	in	IN
cord-321868-xk4yuibj	120	31	Experimental	Experimental	NNP
cord-321868-xk4yuibj	120	32	Procedures	procedure	NNS
cord-321868-xk4yuibj	120	33	.	.	.
cord-321868-xk4yuibj	121	1	The	the	DT
cord-321868-xk4yuibj	121	2	results	result	NNS
cord-321868-xk4yuibj	121	3	are	be	VBP
cord-321868-xk4yuibj	121	4	depicted	depict	VBN
cord-321868-xk4yuibj	121	5	graphically	graphically	RB
cord-321868-xk4yuibj	121	6	in	in	IN
cord-321868-xk4yuibj	121	7	Figure	figure	NN
cord-321868-xk4yuibj	121	8	2	2	CD
cord-321868-xk4yuibj	121	9	.	.	.
cord-321868-xk4yuibj	122	1	The	the	DT
cord-321868-xk4yuibj	122	2	nucleotide	nucleotide	NN
cord-321868-xk4yuibj	122	3	immediately	immediately	RB
cord-321868-xk4yuibj	122	4	5'of	5'of	CD
cord-321868-xk4yuibj	122	5	the	the	DT
cord-321868-xk4yuibj	122	6	9	9	CD
cord-321868-xk4yuibj	122	7	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	122	8	minimal	minimal	JJ
cord-321868-xk4yuibj	122	9	sequence	sequence	NN
cord-321868-xk4yuibj	122	10	is	be	VBZ
cord-321868-xk4yuibj	122	11	unimportant	unimportant	JJ
cord-321868-xk4yuibj	122	12	for	for	IN
cord-321868-xk4yuibj	122	13	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	122	14	,	,	,
cord-321868-xk4yuibj	122	15	as	as	IN
cord-321868-xk4yuibj	122	16	it	-PRON-	PRP
cord-321868-xk4yuibj	122	17	can	can	MD
cord-321868-xk4yuibj	122	18	be	be	VB
cord-321868-xk4yuibj	122	19	any	any	DT
cord-321868-xk4yuibj	122	20	of	of	IN
cord-321868-xk4yuibj	122	21	the	the	DT
cord-321868-xk4yuibj	122	22	four	four	CD
cord-321868-xk4yuibj	122	23	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	122	24	.	.	.
cord-321868-xk4yuibj	123	1	The	the	DT
cord-321868-xk4yuibj	123	2	eighth	eighth	JJ
cord-321868-xk4yuibj	123	3	and	and	CC
cord-321868-xk4yuibj	123	4	ninth	ninth	JJ
cord-321868-xk4yuibj	123	5	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	123	6	can	can	MD
cord-321868-xk4yuibj	123	7	also	also	RB
cord-321868-xk4yuibj	123	8	be	be	VB
cord-321868-xk4yuibj	123	9	changed	change	VBN
cord-321868-xk4yuibj	123	10	to	to	IN
cord-321868-xk4yuibj	123	11	any	any	DT
cord-321868-xk4yuibj	123	12	base	base	NN
cord-321868-xk4yuibj	123	13	without	without	IN
cord-321868-xk4yuibj	123	14	affecting	affect	VBG
cord-321868-xk4yuibj	123	15	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	123	16	.	.	.
cord-321868-xk4yuibj	124	1	However	however	RB
cord-321868-xk4yuibj	124	2	,	,	,
cord-321868-xk4yuibj	124	3	any	any	DT
cord-321868-xk4yuibj	124	4	change	change	NN
cord-321868-xk4yuibj	124	5	to	to	IN
cord-321868-xk4yuibj	124	6	the	the	DT
cord-321868-xk4yuibj	124	7	remaining	remain	VBG
cord-321868-xk4yuibj	124	8	7	7	CD
cord-321868-xk4yuibj	124	9	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	124	10	drastically	drastically	RB
cord-321868-xk4yuibj	124	11	reduces	reduce	VBZ
cord-321868-xk4yuibj	124	12	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	124	13	.	.	.
cord-321868-xk4yuibj	125	1	The	the	DT
cord-321868-xk4yuibj	125	2	essential	essential	JJ
cord-321868-xk4yuibj	125	3	bases	basis	NNS
cord-321868-xk4yuibj	125	4	,	,	,
cord-321868-xk4yuibj	125	5	CUU	CUU	NNP
cord-321868-xk4yuibj	125	6	-	-	HYPH
cord-321868-xk4yuibj	125	7	AGG	agg	NN
cord-321868-xk4yuibj	125	8	-	-	HYPH
cord-321868-xk4yuibj	125	9	C	C	NNP
cord-321868-xk4yuibj	125	10	,	,	,
cord-321868-xk4yuibj	125	11	include	include	VBP
cord-321868-xk4yuibj	125	12	two	two	CD
cord-321868-xk4yuibj	125	13	codons	codon	NNS
cord-321868-xk4yuibj	125	14	of	of	IN
cord-321868-xk4yuibj	125	15	the	the	DT
cord-321868-xk4yuibj	125	16	NA	NA	NNP
cord-321868-xk4yuibj	125	17	reading	reading	NN
cord-321868-xk4yuibj	125	18	frame	frame	NN
cord-321868-xk4yuibj	125	19	plus	plus	IN
cord-321868-xk4yuibj	125	20	a	a	DT
cord-321868-xk4yuibj	125	21	seventh	seventh	JJ
cord-321868-xk4yuibj	125	22	base	base	NN
cord-321868-xk4yuibj	125	23	.	.	.
cord-321868-xk4yuibj	126	1	As	as	IN
cord-321868-xk4yuibj	126	2	can	can	MD
cord-321868-xk4yuibj	126	3	be	be	VB
cord-321868-xk4yuibj	126	4	seen	see	VBN
cord-321868-xk4yuibj	126	5	from	from	IN
cord-321868-xk4yuibj	126	6	closer	close	JJR
cord-321868-xk4yuibj	126	7	inspection	inspection	NN
cord-321868-xk4yuibj	126	8	of	of	IN
cord-321868-xk4yuibj	126	9	the	the	DT
cord-321868-xk4yuibj	126	10	data	datum	NNS
cord-321868-xk4yuibj	126	11	,	,	,
cord-321868-xk4yuibj	126	12	some	some	DT
cord-321868-xk4yuibj	126	13	changes	change	NNS
cord-321868-xk4yuibj	126	14	allow	allow	VBP
cord-321868-xk4yuibj	126	15	lower	low	JJR
cord-321868-xk4yuibj	126	16	levels	level	NNS
cord-321868-xk4yuibj	126	17	of	of	IN
cord-321868-xk4yuibj	126	18	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	126	19	that	that	WDT
cord-321868-xk4yuibj	126	20	are	be	VBP
cord-321868-xk4yuibj	126	21	above	above	IN
cord-321868-xk4yuibj	126	22	background	background	NN
cord-321868-xk4yuibj	126	23	.	.	.
cord-321868-xk4yuibj	127	1	C	C	NNP
cord-321868-xk4yuibj	127	2	or	or	CC
cord-321868-xk4yuibj	127	3	G	g	NN
cord-321868-xk4yuibj	127	4	substitutions	substitution	NNS
cord-321868-xk4yuibj	127	5	for	for	IN
cord-321868-xk4yuibj	127	6	U	U	NNP
cord-321868-xk4yuibj	127	7	at	at	IN
cord-321868-xk4yuibj	127	8	the	the	DT
cord-321868-xk4yuibj	127	9	wobble	wobble	NN
cord-321868-xk4yuibj	127	10	position	position	NN
cord-321868-xk4yuibj	127	11	of	of	IN
cord-321868-xk4yuibj	127	12	the	the	DT
cord-321868-xk4yuibj	127	13	first	first	JJ
cord-321868-xk4yuibj	127	14	codon	codon	NN
cord-321868-xk4yuibj	127	15	allows	allow	VBZ
cord-321868-xk4yuibj	127	16	approximately	approximately	RB
cord-321868-xk4yuibj	127	17	2	2	CD
cord-321868-xk4yuibj	127	18	%	%	NN
cord-321868-xk4yuibj	127	19	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	127	20	.	.	.
cord-321868-xk4yuibj	128	1	Substitution	substitution	NN
cord-321868-xk4yuibj	128	2	of	of	IN
cord-321868-xk4yuibj	128	3	C	C	NNP
cord-321868-xk4yuibj	128	4	or	or	CC
cord-321868-xk4yuibj	128	5	U	U	NNP
cord-321868-xk4yuibj	128	6	for	for	IN
cord-321868-xk4yuibj	128	7	A	a	NN
cord-321868-xk4yuibj	128	8	at	at	IN
cord-321868-xk4yuibj	128	9	the	the	DT
cord-321868-xk4yuibj	128	10	first	first	JJ
cord-321868-xk4yuibj	128	11	position	position	NN
cord-321868-xk4yuibj	128	12	of	of	IN
cord-321868-xk4yuibj	128	13	the	the	DT
cord-321868-xk4yuibj	128	14	second	second	JJ
cord-321868-xk4yuibj	128	15	codon	codon	NN
cord-321868-xk4yuibj	128	16	and	and	CC
cord-321868-xk4yuibj	128	17	replacement	replacement	NN
cord-321868-xk4yuibj	128	18	of	of	IN
cord-321868-xk4yuibj	128	19	G	g	NN
cord-321868-xk4yuibj	128	20	with	with	IN
cord-321868-xk4yuibj	128	21	U	U	NNP
cord-321868-xk4yuibj	128	22	at	at	IN
cord-321868-xk4yuibj	128	23	the	the	DT
cord-321868-xk4yuibj	128	24	wobble	wobble	NN
cord-321868-xk4yuibj	128	25	position	position	NN
cord-321868-xk4yuibj	128	26	of	of	IN
cord-321868-xk4yuibj	128	27	the	the	DT
cord-321868-xk4yuibj	128	28	second	second	JJ
cord-321868-xk4yuibj	128	29	codon	codon	NN
cord-321868-xk4yuibj	128	30	also	also	RB
cord-321868-xk4yuibj	128	31	allow	allow	VBP
cord-321868-xk4yuibj	128	32	lower	low	JJR
cord-321868-xk4yuibj	128	33	levels	level	NNS
cord-321868-xk4yuibj	128	34	of	of	IN
cord-321868-xk4yuibj	128	35	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	128	36	.	.	.
cord-321868-xk4yuibj	129	1	The	the	DT
cord-321868-xk4yuibj	129	2	reason	reason	NN
cord-321868-xk4yuibj	129	3	for	for	IN
cord-321868-xk4yuibj	129	4	the	the	DT
cord-321868-xk4yuibj	129	5	necessity	necessity	NN
cord-321868-xk4yuibj	129	6	of	of	IN
cord-321868-xk4yuibj	129	7	the	the	DT
cord-321868-xk4yuibj	129	8	seventh	seventh	JJ
cord-321868-xk4yuibj	129	9	base	base	NN
cord-321868-xk4yuibj	129	10	is	be	VBZ
cord-321868-xk4yuibj	129	11	unknown	unknown	JJ
cord-321868-xk4yuibj	129	12	but	but	CC
cord-321868-xk4yuibj	129	13	can	can	MD
cord-321868-xk4yuibj	129	14	probably	probably	RB
cord-321868-xk4yuibj	129	15	be	be	VB
cord-321868-xk4yuibj	129	16	attributed	attribute	VBN
cord-321868-xk4yuibj	129	17	to	to	IN
cord-321868-xk4yuibj	129	18	a	a	DT
cord-321868-xk4yuibj	129	19	context	context	NN
cord-321868-xk4yuibj	129	20	effect	effect	NN
cord-321868-xk4yuibj	129	21	on	on	IN
cord-321868-xk4yuibj	129	22	decoding	decode	VBG
cord-321868-xk4yuibj	129	23	of	of	IN
cord-321868-xk4yuibj	129	24	the	the	DT
cord-321868-xk4yuibj	129	25	preceding	precede	VBG
cord-321868-xk4yuibj	129	26	codon	codon	NN
cord-321868-xk4yuibj	129	27	.	.	.
cord-321868-xk4yuibj	130	1	Context	context	JJ
cord-321868-xk4yuibj	130	2	effects	effect	NNS
cord-321868-xk4yuibj	130	3	are	be	VBP
cord-321868-xk4yuibj	130	4	known	know	VBN
cord-321868-xk4yuibj	130	5	to	to	TO
cord-321868-xk4yuibj	130	6	involve	involve	VB
cord-321868-xk4yuibj	130	7	the	the	DT
cord-321868-xk4yuibj	130	8	nucleotide	nucleotide	NN
cord-321868-xk4yuibj	130	9	immediately	immediately	RB
cord-321868-xk4yuibj	130	10	3'of	3'of	VBZ
cord-321868-xk4yuibj	130	11	a	a	DT
cord-321868-xk4yuibj	130	12	codon	codon	NN
cord-321868-xk4yuibj	130	13	(	(	-LRB-
cord-321868-xk4yuibj	130	14	Bossi	Bossi	NNP
cord-321868-xk4yuibj	130	15	,	,	,
cord-321868-xk4yuibj	130	16	1983	1983	CD
cord-321868-xk4yuibj	130	17	;	;	:
cord-321868-xk4yuibj	131	1	Bossi	Bossi	NNP
cord-321868-xk4yuibj	131	2	and	and	CC
cord-321868-xk4yuibj	131	3	Roth	Roth	NNP
cord-321868-xk4yuibj	131	4	,	,	,
cord-321868-xk4yuibj	131	5	1980	1980	CD
cord-321868-xk4yuibj	131	6	;	;	:
cord-321868-xk4yuibj	131	7	Carrier	Carrier	NNP
cord-321868-xk4yuibj	131	8	and	and	CC
cord-321868-xk4yuibj	131	9	Buckingham	Buckingham	NNP
cord-321868-xk4yuibj	131	10	,	,	,
cord-321868-xk4yuibj	131	11	1984	1984	CD
cord-321868-xk4yuibj	131	12	;	;	:
cord-321868-xk4yuibj	131	13	Fluck	Fluck	NNP
cord-321868-xk4yuibj	131	14	et	et	NNP
cord-321868-xk4yuibj	131	15	al	al	NNP
cord-321868-xk4yuibj	131	16	.	.	NNP
cord-321868-xk4yuibj	131	17	,	,	,
cord-321868-xk4yuibj	131	18	1977	1977	CD
cord-321868-xk4yuibj	131	19	;	;	:
cord-321868-xk4yuibj	131	20	Miller	Miller	NNP
cord-321868-xk4yuibj	131	21	and	and	CC
cord-321868-xk4yuibj	131	22	Albertini	Albertini	NNP
cord-321868-xk4yuibj	131	23	,	,	,
cord-321868-xk4yuibj	131	24	1983	1983	CD
cord-321868-xk4yuibj	131	25	;	;	.
cord-321868-xk4yuibj	132	1	Murgola	Murgola	NNP
cord-321868-xk4yuibj	132	2	et	et	NNP
cord-321868-xk4yuibj	132	3	al	al	NNP
cord-321868-xk4yuibj	132	4	.	.	NNP
cord-321868-xk4yuibj	132	5	,	,	,
cord-321868-xk4yuibj	132	6	1984	1984	CD
cord-321868-xk4yuibj	132	7	;	;	:
cord-321868-xk4yuibj	132	8	Weiss	Weiss	NNP
cord-321868-xk4yuibj	132	9	,	,	,
cord-321868-xk4yuibj	132	10	1984	1984	CD
cord-321868-xk4yuibj	132	11	;	;	:
cord-321868-xk4yuibj	132	12	Weiss	Weiss	NNP
cord-321868-xk4yuibj	132	13	and	and	CC
cord-321868-xk4yuibj	132	14	Gallant	Gallant	NNP
cord-321868-xk4yuibj	132	15	,	,	,
cord-321868-xk4yuibj	132	16	1988	1988	CD
cord-321868-xk4yuibj	132	17	)	)	-RRB-
cord-321868-xk4yuibj	132	18	.	.	.
cord-321868-xk4yuibj	133	1	Occurs	occur	VBZ
cord-321868-xk4yuibj	133	2	When	when	WRB
cord-321868-xk4yuibj	133	3	Peptidyl	Peptidyl	NNP
cord-321868-xk4yuibj	133	4	-	-	HYPH
cord-321868-xk4yuibj	133	5	tRNAbU	tRNAbU	NNP
cord-321868-xk4yuibj	133	6	Is	be	VBZ
cord-321868-xk4yuibj	133	7	Bound	bind	VBN
cord-321868-xk4yuibj	133	8	to	to	IN
cord-321868-xk4yuibj	133	9	the	the	DT
cord-321868-xk4yuibj	133	10	CUU	CUU	NNP
cord-321868-xk4yuibj	133	11	Codon	Codon	NNP
cord-321868-xk4yuibj	133	12	and	and	CC
cord-321868-xk4yuibj	133	13	Does	do	VBZ
cord-321868-xk4yuibj	133	14	Not	not	RB
cord-321868-xk4yuibj	133	15	Involve	involve	VB
cord-321868-xk4yuibj	133	16	Simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	133	17	Slippage	slippage	NN
cord-321868-xk4yuibj	134	1	The	the	DT
cord-321868-xk4yuibj	134	2	7	7	CD
cord-321868-xk4yuibj	134	3	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	134	4	minimal	minimal	JJ
cord-321868-xk4yuibj	134	5	sequence	sequence	NN
cord-321868-xk4yuibj	134	6	defined	define	VBN
cord-321868-xk4yuibj	134	7	above	above	RB
cord-321868-xk4yuibj	134	8	includes	include	VBZ
cord-321868-xk4yuibj	134	9	two	two	CD
cord-321868-xk4yuibj	134	10	unusual	unusual	JJ
cord-321868-xk4yuibj	134	11	features	feature	NNS
cord-321868-xk4yuibj	134	12	.	.	.
cord-321868-xk4yuibj	135	1	First	first	RB
cord-321868-xk4yuibj	135	2	,	,	,
cord-321868-xk4yuibj	135	3	there	there	EX
cord-321868-xk4yuibj	135	4	are	be	VBP
cord-321868-xk4yuibj	135	5	overlapping	overlap	VBG
cord-321868-xk4yuibj	135	6	leucine	leucine	NN
cord-321868-xk4yuibj	135	7	codons	codon	NNS
cord-321868-xk4yuibj	135	8	(	(	-LRB-
cord-321868-xk4yuibj	135	9	CUU	CUU	NNP
cord-321868-xk4yuibj	135	10	and	and	CC
cord-321868-xk4yuibj	135	11	UUA	UUA	NNP
cord-321868-xk4yuibj	135	12	)	)	-RRB-
cord-321868-xk4yuibj	135	13	in	in	IN
cord-321868-xk4yuibj	135	14	the	the	DT
cord-321868-xk4yuibj	135	15	0	0	CD
cord-321868-xk4yuibj	135	16	and	and	CC
cord-321868-xk4yuibj	135	17	+	+	CC
cord-321868-xk4yuibj	135	18	l	l	NN
cord-321868-xk4yuibj	135	19	reading	reading	NN
cord-321868-xk4yuibj	135	20	frames	frame	NNS
cord-321868-xk4yuibj	135	21	.	.	.
cord-321868-xk4yuibj	136	1	In	in	IN
cord-321868-xk4yuibj	136	2	nearly	nearly	RB
cord-321868-xk4yuibj	136	3	all	all	DT
cord-321868-xk4yuibj	136	4	organisms	organism	NNS
cord-321868-xk4yuibj	136	5	these	these	DT
cord-321868-xk4yuibj	136	6	two	two	CD
cord-321868-xk4yuibj	136	7	codons	codon	NNS
cord-321868-xk4yuibj	136	8	are	be	VBP
cord-321868-xk4yuibj	136	9	decoded	decode	VBN
cord-321868-xk4yuibj	136	10	by	by	IN
cord-321868-xk4yuibj	136	11	distinct	distinct	JJ
cord-321868-xk4yuibj	136	12	isoaccepting	isoaccepting	NN
cord-321868-xk4yuibj	136	13	species	specie	NNS
cord-321868-xk4yuibj	136	14	.	.	.
cord-321868-xk4yuibj	137	1	Yeast	yeast	NN
cord-321868-xk4yuibj	137	2	is	be	VBZ
cord-321868-xk4yuibj	137	3	unusual	unusual	JJ
cord-321868-xk4yuibj	137	4	in	in	IN
cord-321868-xk4yuibj	137	5	that	that	IN
cord-321868-xk4yuibj	137	6	it	-PRON-	PRP
cord-321868-xk4yuibj	137	7	encodes	encode	VBZ
cord-321868-xk4yuibj	137	8	a	a	DT
cord-321868-xk4yuibj	137	9	tRNA	trna	NN
cord-321868-xk4yuibj	137	10	,	,	,
cord-321868-xk4yuibj	137	11	tRNAf	trnaf	ADD
cord-321868-xk4yuibj	137	12	&	&	CC
cord-321868-xk4yuibj	137	13	(	(	-LRB-
cord-321868-xk4yuibj	137	14	previously	previously	RB
cord-321868-xk4yuibj	137	15	known	know	VBN
cord-321868-xk4yuibj	137	16	as	as	IN
cord-321868-xk4yuibj	137	17	tRNA	trna	NN
cord-321868-xk4yuibj	137	18	:	:	:
cord-321868-xk4yuibj	137	19	B	b	NN
cord-321868-xk4yuibj	137	20	"	"	''
cord-321868-xk4yuibj	137	21	)	)	-RRB-
cord-321868-xk4yuibj	137	22	that	that	WDT
cord-321868-xk4yuibj	137	23	decodes	decode	VBZ
cord-321868-xk4yuibj	137	24	all	all	DT
cord-321868-xk4yuibj	137	25	six	six	CD
cord-321868-xk4yuibj	137	26	leucine	leucine	NN
cord-321868-xk4yuibj	137	27	codons	codon	NNS
cord-321868-xk4yuibj	137	28	(	(	-LRB-
cord-321868-xk4yuibj	137	29	Weissenbach	Weissenbach	NNP
cord-321868-xk4yuibj	137	30	et	et	FW
cord-321868-xk4yuibj	137	31	al	al	NNP
cord-321868-xk4yuibj	137	32	.	.	NNP
cord-321868-xk4yuibj	137	33	,	,	,
cord-321868-xk4yuibj	137	34	1977	1977	CD
cord-321868-xk4yuibj	137	35	)	)	-RRB-
cord-321868-xk4yuibj	137	36	.	.	.
cord-321868-xk4yuibj	138	1	The	the	DT
cord-321868-xk4yuibj	138	2	expanded	expand	VBN
cord-321868-xk4yuibj	138	3	recognition	recognition	NN
cord-321868-xk4yuibj	138	4	requires	require	VBZ
cord-321868-xk4yuibj	138	5	an	an	DT
cord-321868-xk4yuibj	138	6	unmodified	unmodified	JJ
cord-321868-xk4yuibj	138	7	uracil	uracil	NN
cord-321868-xk4yuibj	138	8	at	at	IN
cord-321868-xk4yuibj	138	9	the	the	DT
cord-321868-xk4yuibj	138	10	wobble	wobble	NN
cord-321868-xk4yuibj	138	11	position	position	NN
cord-321868-xk4yuibj	138	12	of	of	IN
cord-321868-xk4yuibj	138	13	the	the	DT
cord-321868-xk4yuibj	138	14	anticodon	anticodon	NN
cord-321868-xk4yuibj	138	15	(	(	-LRB-
cord-321868-xk4yuibj	138	16	Randerath	Randerath	NNP
cord-321868-xk4yuibj	138	17	et	et	FW
cord-321868-xk4yuibj	138	18	al	al	NNP
cord-321868-xk4yuibj	138	19	.	.	NNP
cord-321868-xk4yuibj	138	20	,	,	,
cord-321868-xk4yuibj	138	21	1979	1979	CD
cord-321868-xk4yuibj	138	22	)	)	-RRB-
cord-321868-xk4yuibj	138	23	.	.	.
cord-321868-xk4yuibj	139	1	Frameshifting	Frameshifting	NNP
cord-321868-xk4yuibj	139	2	could	could	MD
cord-321868-xk4yuibj	139	3	involve	involve	VB
cord-321868-xk4yuibj	139	4	slippage	slippage	NN
cord-321868-xk4yuibj	139	5	of	of	IN
cord-321868-xk4yuibj	139	6	this	this	DT
cord-321868-xk4yuibj	139	7	tRNA	trna	NN
cord-321868-xk4yuibj	139	8	between	between	IN
cord-321868-xk4yuibj	139	9	the	the	DT
cord-321868-xk4yuibj	139	10	two	two	CD
cord-321868-xk4yuibj	139	11	leucine	leucine	NN
cord-321868-xk4yuibj	139	12	codons	codon	NNS
cord-321868-xk4yuibj	139	13	.	.	.
cord-321868-xk4yuibj	140	1	Second	second	RB
cord-321868-xk4yuibj	140	2	,	,	,
cord-321868-xk4yuibj	140	3	the	the	DT
cord-321868-xk4yuibj	140	4	next	next	JJ
cord-321868-xk4yuibj	140	5	codon	codon	NN
cord-321868-xk4yuibj	140	6	,	,	,
cord-321868-xk4yuibj	140	7	AGG	AGG	NNP
cord-321868-xk4yuibj	140	8	(	(	-LRB-
cord-321868-xk4yuibj	140	9	Arg	Arg	NNP
cord-321868-xk4yuibj	140	10	)	)	-RRB-
cord-321868-xk4yuibj	140	11	,	,	,
cord-321868-xk4yuibj	140	12	is	be	VBZ
cord-321868-xk4yuibj	140	13	recognized	recognize	VBN
cord-321868-xk4yuibj	140	14	by	by	IN
cord-321868-xk4yuibj	140	15	a	a	DT
cord-321868-xk4yuibj	140	16	low	low	JJ
cord-321868-xk4yuibj	140	17	-	-	HYPH
cord-321868-xk4yuibj	140	18	abundance	abundance	NN
cord-321868-xk4yuibj	140	19	tRNA	trna	NN
cord-321868-xk4yuibj	140	20	encoded	encode	VBN
cord-321868-xk4yuibj	140	21	by	by	IN
cord-321868-xk4yuibj	140	22	a	a	DT
cord-321868-xk4yuibj	140	23	single	single	JJ
cord-321868-xk4yuibj	140	24	nuclear	nuclear	JJ
cord-321868-xk4yuibj	140	25	gene	gene	NN
cord-321868-xk4yuibj	140	26	,	,	,
cord-321868-xk4yuibj	140	27	tRN	tRN	NNP
cord-321868-xk4yuibj	140	28	&	&	CC
cord-321868-xk4yuibj	140	29	?	?	NNP
cord-321868-xk4yuibj	140	30	,	,	,
cord-321868-xk4yuibj	140	31	,	,	,
cord-321868-xk4yuibj	140	32	.	.	.
cord-321868-xk4yuibj	141	1	Deletion	deletion	NN
cord-321868-xk4yuibj	141	2	of	of	IN
cord-321868-xk4yuibj	141	3	this	this	DT
cord-321868-xk4yuibj	141	4	gene	gene	NN
cord-321868-xk4yuibj	141	5	is	be	VBZ
cord-321868-xk4yuibj	141	6	lethal	lethal	JJ
cord-321868-xk4yuibj	141	7	to	to	IN
cord-321868-xk4yuibj	141	8	yeast	yeast	NN
cord-321868-xk4yuibj	142	1	(	(	-LRB-
cord-321868-xk4yuibj	142	2	Gafner	Gafner	NNP
cord-321868-xk4yuibj	142	3	et	et	NNP
cord-321868-xk4yuibj	142	4	al	al	NNP
cord-321868-xk4yuibj	142	5	.	.	NNP
cord-321868-xk4yuibj	142	6	,	,	,
cord-321868-xk4yuibj	142	7	1983	1983	CD
cord-321868-xk4yuibj	142	8	)	)	-RRB-
cord-321868-xk4yuibj	142	9	.	.	.
cord-321868-xk4yuibj	143	1	Two	two	CD
cord-321868-xk4yuibj	143	2	models	model	NNS
cord-321868-xk4yuibj	143	3	can	can	MD
cord-321868-xk4yuibj	143	4	account	account	VB
cord-321868-xk4yuibj	143	5	for	for	IN
cord-321868-xk4yuibj	143	6	the	the	DT
cord-321868-xk4yuibj	143	7	necessity	necessity	NN
cord-321868-xk4yuibj	143	8	of	of	IN
cord-321868-xk4yuibj	143	9	the	the	DT
cord-321868-xk4yuibj	143	10	CUU	CUU	NNP
cord-321868-xk4yuibj	143	11	Shown	show	VBN
cord-321868-xk4yuibj	143	12	boxed	box	VBN
cord-321868-xk4yuibj	143	13	on	on	IN
cord-321868-xk4yuibj	143	14	the	the	DT
cord-321868-xk4yuibj	143	15	x	x	NN
cord-321868-xk4yuibj	143	16	-	-	HYPH
cord-321868-xk4yuibj	143	17	axis	axis	NN
cord-321868-xk4yuibj	143	18	is	be	VBZ
cord-321868-xk4yuibj	143	19	the	the	DT
cord-321868-xk4yuibj	143	20	wild	wild	JJ
cord-321868-xk4yuibj	143	21	-	-	HYPH
cord-321868-xk4yuibj	143	22	type	type	NN
cord-321868-xk4yuibj	143	23	sequence	sequence	NN
cord-321868-xk4yuibj	143	24	of	of	IN
cord-321868-xk4yuibj	143	25	the	the	DT
cord-321868-xk4yuibj	143	26	frameshift	frameshift	NN
cord-321868-xk4yuibj	143	27	site	site	NN
cord-321868-xk4yuibj	143	28	.	.	.
cord-321868-xk4yuibj	144	1	The	the	DT
cord-321868-xk4yuibj	144	2	hatched	hatch	VBN
cord-321868-xk4yuibj	144	3	portion	portion	NN
cord-321868-xk4yuibj	144	4	indicates	indicate	VBZ
cord-321868-xk4yuibj	144	5	the	the	DT
cord-321868-xk4yuibj	144	6	essential	essential	JJ
cord-321868-xk4yuibj	144	7	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	144	8	for	for	IN
cord-321868-xk4yuibj	144	9	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	144	10	.	.	.
cord-321868-xk4yuibj	145	1	Above	above	IN
cord-321868-xk4yuibj	145	2	each	each	DT
cord-321868-xk4yuibj	145	3	boxed	box	VBN
cord-321868-xk4yuibj	145	4	nucleotide	nucleotide	NN
cord-321868-xk4yuibj	145	5	are	be	VBP
cord-321868-xk4yuibj	145	6	the	the	DT
cord-321868-xk4yuibj	145	7	miasense	miasense	NN
cord-321868-xk4yuibj	145	8	substitutions	substitution	NNS
cord-321868-xk4yuibj	145	9	generated	generate	VBN
cord-321868-xk4yuibj	145	10	for	for	IN
cord-321868-xk4yuibj	145	11	each	each	DT
cord-321868-xk4yuibj	145	12	position	position	NN
cord-321868-xk4yuibj	145	13	of	of	IN
cord-321868-xk4yuibj	145	14	the	the	DT
cord-321868-xk4yuibj	145	15	sequence	sequence	NN
cord-321868-xk4yuibj	145	16	.	.	.
cord-321868-xk4yuibj	146	1	The	the	DT
cord-321868-xk4yuibj	146	2	percent	percent	NN
cord-321868-xk4yuibj	146	3	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	146	4	for	for	IN
cord-321868-xk4yuibj	146	5	each	each	DT
cord-321868-xk4yuibj	146	6	substitution	substitution	NN
cord-321868-xk4yuibj	146	7	is	be	VBZ
cord-321868-xk4yuibj	146	8	shown	show	VBN
cord-321868-xk4yuibj	146	9	graphically	graphically	RB
cord-321868-xk4yuibj	146	10	.	.	.
cord-321868-xk4yuibj	147	1	if	if	IN
cord-321868-xk4yuibj	147	2	Ty	Ty	NNP
cord-321868-xk4yuibj	147	3	elements	element	NNS
cord-321868-xk4yuibj	147	4	employ	employ	VBP
cord-321868-xk4yuibj	147	5	a	a	DT
cord-321868-xk4yuibj	147	6	peptidyl	peptidyl	NNP
cord-321868-xk4yuibj	147	7	-	-	HYPH
cord-321868-xk4yuibj	147	8	tRNA	trna	NN
cord-321868-xk4yuibj	147	9	slippage	slippage	NN
cord-321868-xk4yuibj	147	10	method	method	NN
cord-321868-xk4yuibj	147	11	of	of	IN
cord-321868-xk4yuibj	147	12	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	147	13	as	as	IN
cord-321868-xk4yuibj	147	14	described	describe	VBN
cord-321868-xk4yuibj	147	15	in	in	IN
cord-321868-xk4yuibj	147	16	the	the	DT
cord-321868-xk4yuibj	147	17	text	text	NN
cord-321868-xk4yuibj	147	18	.	.	.
cord-321868-xk4yuibj	148	1	A	a	DT
cord-321868-xk4yuibj	148	2	partial	partial	JJ
cord-321868-xk4yuibj	148	3	RNA	rna	NN
cord-321868-xk4yuibj	148	4	sequence	sequence	NN
cord-321868-xk4yuibj	148	5	from	from	IN
cord-321868-xk4yuibj	148	6	the	the	DT
cord-321868-xk4yuibj	148	7	AUG	AUG	NNP
cord-321868-xk4yuibj	148	8	codon	codon	NN
cord-321868-xk4yuibj	148	9	is	be	VBZ
cord-321868-xk4yuibj	148	10	provided	provide	VBN
cord-321868-xk4yuibj	148	11	for	for	IN
cord-321868-xk4yuibj	148	12	reference	reference	NN
cord-321868-xk4yuibj	148	13	.	.	.
cord-321868-xk4yuibj	149	1	(	(	-LRB-
cord-321868-xk4yuibj	149	2	B	b	NN
cord-321868-xk4yuibj	149	3	)	)	-RRB-
cord-321868-xk4yuibj	149	4	Predicted	predict	VBN
cord-321868-xk4yuibj	149	5	amino	amino	NN
cord-321868-xk4yuibj	149	6	acid	acid	NN
cord-321868-xk4yuibj	149	7	sequence	sequence	NN
cord-321868-xk4yuibj	149	8	through	through	IN
cord-321868-xk4yuibj	149	9	the	the	DT
cord-321868-xk4yuibj	149	10	7	7	CD
cord-321868-xk4yuibj	149	11	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	149	12	frameshift	frameshift	NN
cord-321868-xk4yuibj	149	13	site	site	NN
cord-321868-xk4yuibj	149	14	(	(	-LRB-
cord-321868-xk4yuibj	149	15	amino	amino	JJ
cord-321868-xk4yuibj	149	16	acids	acid	NNS
cord-321868-xk4yuibj	149	17	shown	show	VBN
cord-321868-xk4yuibj	149	18	numbered	number	VBD
cord-321868-xk4yuibj	149	19	)	)	-RRB-
cord-321868-xk4yuibj	149	20	if	if	IN
cord-321868-xk4yuibj	149	21	Ty	Ty	NNP
cord-321868-xk4yuibj	149	22	elements	element	NNS
cord-321868-xk4yuibj	149	23	employ	employ	VBP
cord-321868-xk4yuibj	149	24	the	the	DT
cord-321868-xk4yuibj	149	25	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	149	26	-	-	HYPH
cord-321868-xk4yuibj	149	27	slippage	slippage	NN
cord-321868-xk4yuibj	149	28	method	method	NN
cord-321868-xk4yuibj	149	29	of	of	IN
cord-321868-xk4yuibj	149	30	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	149	31	seen	see	VBN
cord-321868-xk4yuibj	149	32	in	in	IN
cord-321868-xk4yuibj	149	33	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	149	34	of	of	IN
cord-321868-xk4yuibj	149	35	higher	high	JJR
cord-321868-xk4yuibj	149	36	cells	cell	NNS
cord-321868-xk4yuibj	149	37	.	.	.
cord-321868-xk4yuibj	150	1	A	a	DT
cord-321868-xk4yuibj	150	2	partial	partial	JJ
cord-321868-xk4yuibj	150	3	RNA	rna	NN
cord-321868-xk4yuibj	150	4	sequence	sequence	NN
cord-321868-xk4yuibj	150	5	from	from	IN
cord-321868-xk4yuibj	150	6	the	the	DT
cord-321868-xk4yuibj	150	7	AUG	AUG	NNP
cord-321868-xk4yuibj	150	8	codon	codon	NN
cord-321868-xk4yuibj	150	9	is	be	VBZ
cord-321868-xk4yuibj	150	10	provided	provide	VBN
cord-321868-xk4yuibj	150	11	for	for	IN
cord-321868-xk4yuibj	150	12	reference	reference	NN
cord-321868-xk4yuibj	150	13	.	.	.
cord-321868-xk4yuibj	151	1	(	(	-LRB-
cord-321868-xk4yuibj	151	2	C	C	NNP
cord-321868-xk4yuibj	151	3	)	)	-RRB-
cord-321868-xk4yuibj	151	4	Amino	amino	NN
cord-321868-xk4yuibj	151	5	acid	acid	NN
cord-321868-xk4yuibj	151	6	sequence	sequence	NN
cord-321868-xk4yuibj	151	7	datathrough	datathrough	IN
cord-321868-xk4yuibj	151	8	the	the	DT
cord-321868-xk4yuibj	151	9	7	7	CD
cord-321868-xk4yuibj	151	10	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	151	11	frameshift	frameshift	NN
cord-321868-xk4yuibj	151	12	site	site	NN
cord-321868-xk4yuibj	151	13	.	.	.
cord-321868-xk4yuibj	152	1	Histograms	Histograms	NNP
cord-321868-xk4yuibj	152	2	of	of	IN
cord-321868-xk4yuibj	152	3	relevant	relevant	JJ
cord-321868-xk4yuibj	152	4	PTH	PTH	NNP
cord-321868-xk4yuibj	152	5	-	-	HYPH
cord-321868-xk4yuibj	152	6	amino	amino	NN
cord-321868-xk4yuibj	152	7	acids	acid	NNS
cord-321868-xk4yuibj	152	8	through	through	IN
cord-321868-xk4yuibj	152	9	11	11	CD
cord-321868-xk4yuibj	152	10	cycles	cycle	NNS
cord-321868-xk4yuibj	152	11	of	of	IN
cord-321868-xk4yuibj	152	12	Edman	Edman	NNP
cord-321868-xk4yuibj	152	13	degradation	degradation	NN
cord-321868-xk4yuibj	152	14	are	be	VBP
cord-321868-xk4yuibj	152	15	shown	show	VBN
cord-321868-xk4yuibj	152	16	with	with	IN
cord-321868-xk4yuibj	152	17	the	the	DT
cord-321868-xk4yuibj	152	18	major	major	JJ
cord-321868-xk4yuibj	152	19	amino	amino	NN
cord-321868-xk4yuibj	152	20	acid	acid	NN
cord-321868-xk4yuibj	152	21	present	present	JJ
cord-321868-xk4yuibj	152	22	in	in	IN
cord-321868-xk4yuibj	152	23	each	each	DT
cord-321868-xk4yuibj	152	24	cycle	cycle	NN
cord-321868-xk4yuibj	152	25	indicated	indicate	VBN
cord-321868-xk4yuibj	152	26	above	above	IN
cord-321868-xk4yuibj	152	27	the	the	DT
cord-321868-xk4yuibj	152	28	histograms	histogram	NNS
cord-321868-xk4yuibj	152	29	and	and	CC
cord-321868-xk4yuibj	152	30	above	above	IN
cord-321868-xk4yuibj	152	31	the	the	DT
cord-321868-xk4yuibj	152	32	mRNA	mRNA	NNP
cord-321868-xk4yuibj	152	33	sequence	sequence	NN
cord-321868-xk4yuibj	152	34	in	in	IN
cord-321868-xk4yuibj	152	35	(	(	-LRB-
cord-321868-xk4yuibj	152	36	B	b	NN
cord-321868-xk4yuibj	152	37	)	)	-RRB-
cord-321868-xk4yuibj	152	38	.	.	.
cord-321868-xk4yuibj	153	1	Cycle	Cycle	NNP
cord-321868-xk4yuibj	153	2	8	8	CD
cord-321868-xk4yuibj	153	3	,	,	,
cord-321868-xk4yuibj	153	4	which	which	WDT
cord-321868-xk4yuibj	153	5	is	be	VBZ
cord-321868-xk4yuibj	153	6	predicted	predict	VBN
cord-321868-xk4yuibj	153	7	to	to	TO
cord-321868-xk4yuibj	153	8	yield	yield	VB
cord-321868-xk4yuibj	153	9	His	-PRON-	PRP$
cord-321868-xk4yuibj	153	10	according	accord	VBG
cord-321868-xk4yuibj	153	11	to	to	IN
cord-321868-xk4yuibj	153	12	the	the	DT
cord-321868-xk4yuibj	153	13	RNA	RNA	NNP
cord-321868-xk4yuibj	153	14	sequence	sequence	NN
cord-321868-xk4yuibj	153	15	,	,	,
cord-321868-xk4yuibj	153	16	gave	give	VBD
cord-321868-xk4yuibj	153	17	a	a	DT
cord-321868-xk4yuibj	153	18	weak	weak	JJ
cord-321868-xk4yuibj	153	19	signal	signal	NN
cord-321868-xk4yuibj	153	20	,	,	,
cord-321868-xk4yuibj	153	21	and	and	CC
cord-321868-xk4yuibj	153	22	no	no	DT
cord-321868-xk4yuibj	153	23	assignment	assignment	NN
cord-321868-xk4yuibj	153	24	was	be	VBD
cord-321868-xk4yuibj	153	25	made	make	VBN
cord-321868-xk4yuibj	153	26	.	.	.
cord-321868-xk4yuibj	154	1	No	no	DT
cord-321868-xk4yuibj	154	2	other	other	JJ
cord-321868-xk4yuibj	154	3	amino	amino	NN
cord-321868-xk4yuibj	154	4	acid	acid	NN
cord-321868-xk4yuibj	154	5	can	can	MD
cord-321868-xk4yuibj	154	6	be	be	VB
cord-321868-xk4yuibj	154	7	detected	detect	VBN
cord-321868-xk4yuibj	154	8	.	.	.
cord-321868-xk4yuibj	155	1	The	the	DT
cord-321868-xk4yuibj	155	2	14	14	CD
cord-321868-xk4yuibj	155	3	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	155	4	frameshift	frameshift	NN
cord-321868-xk4yuibj	155	5	site	site	NN
cord-321868-xk4yuibj	155	6	has	have	VBZ
cord-321868-xk4yuibj	155	7	a	a	DT
cord-321868-xk4yuibj	155	8	Gln	Gln	NNP
cord-321868-xk4yuibj	155	9	residue	residue	NN
cord-321868-xk4yuibj	155	10	(	(	-LRB-
cord-321868-xk4yuibj	155	11	rather	rather	RB
cord-321868-xk4yuibj	155	12	than	than	IN
cord-321868-xk4yuibj	155	13	His	-PRON-	PRP$
cord-321868-xk4yuibj	155	14	)	)	-RRB-
cord-321868-xk4yuibj	155	15	following	follow	VBG
cord-321868-xk4yuibj	155	16	Gly	Gly	NNP
cord-321868-xk4yuibj	155	17	.	.	.
cord-321868-xk4yuibj	156	1	The	the	DT
cord-321868-xk4yuibj	156	2	amino	amino	NN
cord-321868-xk4yuibj	156	3	acid	acid	NN
cord-321868-xk4yuibj	156	4	sequence	sequence	NN
cord-321868-xk4yuibj	156	5	through	through	IN
cord-321868-xk4yuibj	156	6	the	the	DT
cord-321868-xk4yuibj	156	7	14	14	CD
cord-321868-xk4yuibj	156	8	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	156	9	site	site	NN
cord-321868-xk4yuibj	156	10	confirms	confirm	VBZ
cord-321868-xk4yuibj	156	11	the	the	DT
cord-321868-xk4yuibj	156	12	Gln	Gln	NNP
cord-321868-xk4yuibj	156	13	residue	residue	NN
cord-321868-xk4yuibj	156	14	after	after	IN
cord-321868-xk4yuibj	156	15	Gly	Gly	NNP
cord-321868-xk4yuibj	156	16	(	(	-LRB-
cord-321868-xk4yuibj	156	17	data	datum	NNS
cord-321868-xk4yuibj	156	18	not	not	RB
cord-321868-xk4yuibj	156	19	shown	show	VBN
cord-321868-xk4yuibj	156	20	)	)	-RRB-
cord-321868-xk4yuibj	156	21	,	,	,
cord-321868-xk4yuibj	156	22	supporting	support	VBG
cord-321868-xk4yuibj	156	23	the	the	DT
cord-321868-xk4yuibj	156	24	notion	notion	NN
cord-321868-xk4yuibj	156	25	that	that	IN
cord-321868-xk4yuibj	156	26	translation	translation	NN
cord-321868-xk4yuibj	156	27	shifts	shift	VBZ
cord-321868-xk4yuibj	156	28	to	to	IN
cord-321868-xk4yuibj	156	29	the	the	DT
cord-321868-xk4yuibj	156	30	+	+	CC
cord-321868-xk4yuibj	156	31	l	l	NN
cord-321868-xk4yuibj	156	32	reading	reading	NN
cord-321868-xk4yuibj	156	33	frame	frame	NN
cord-321868-xk4yuibj	156	34	by	by	IN
cord-321868-xk4yuibj	156	35	peptidyl	peptidyl	NNP
cord-321868-xk4yuibj	156	36	-	-	HYPH
cord-321868-xk4yuibj	156	37	tRNA	trna	NN
cord-321868-xk4yuibj	156	38	slippage	slippage	NN
cord-321868-xk4yuibj	156	39	on	on	IN
cord-321868-xk4yuibj	156	40	the	the	DT
cord-321868-xk4yuibj	156	41	CUU	CUU	NNP
cord-321868-xk4yuibj	156	42	-	-	HYPH
cord-321868-xk4yuibj	156	43	Leu	Leu	NNP
cord-321868-xk4yuibj	156	44	codon	codon	NN
cord-321868-xk4yuibj	156	45	.	.	.
cord-321868-xk4yuibj	157	1	and	and	CC
cord-321868-xk4yuibj	157	2	AGG	AGG	NNP
cord-321868-xk4yuibj	157	3	codons	codon	NNS
cord-321868-xk4yuibj	157	4	.	.	.
cord-321868-xk4yuibj	158	1	In	in	IN
cord-321868-xk4yuibj	158	2	RSV	RSV	NNP
cord-321868-xk4yuibj	158	3	,	,	,
cord-321868-xk4yuibj	158	4	HIV	HIV	NNP
cord-321868-xk4yuibj	158	5	-	-	HYPH
cord-321868-xk4yuibj	158	6	l	l	NNP
cord-321868-xk4yuibj	158	7	,	,	,
cord-321868-xk4yuibj	158	8	MMTV	MMTV	NNP
cord-321868-xk4yuibj	158	9	,	,	,
cord-321868-xk4yuibj	158	10	IBV	IBV	NNP
cord-321868-xk4yuibj	158	11	,	,	,
cord-321868-xk4yuibj	158	12	bovine	bovine	JJ
cord-321868-xk4yuibj	158	13	leukemia	leukemia	NN
cord-321868-xk4yuibj	158	14	virus	virus	NN
cord-321868-xk4yuibj	158	15	(	(	-LRB-
cord-321868-xk4yuibj	158	16	BLV	BLV	NNP
cord-321868-xk4yuibj	158	17	)	)	-RRB-
cord-321868-xk4yuibj	158	18	,	,	,
cord-321868-xk4yuibj	158	19	and	and	CC
cord-321868-xk4yuibj	158	20	the	the	DT
cord-321868-xk4yuibj	158	21	simian	simian	JJ
cord-321868-xk4yuibj	158	22	retrovirus	retrovirus	NN
cord-321868-xk4yuibj	158	23	type	type	NN
cord-321868-xk4yuibj	158	24	1	1	CD
cord-321868-xk4yuibj	158	25	(	(	-LRB-
cord-321868-xk4yuibj	158	26	SRV	SRV	NNP
cord-321868-xk4yuibj	158	27	-	-	HYPH
cord-321868-xk4yuibj	158	28	l	l	NNP
cord-321868-xk4yuibj	158	29	)	)	-RRB-
cord-321868-xk4yuibj	158	30	,	,	,
cord-321868-xk4yuibj	158	31	a	a	DT
cord-321868-xk4yuibj	158	32	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	158	33	slippage	slippage	NN
cord-321868-xk4yuibj	158	34	of	of	IN
cord-321868-xk4yuibj	158	35	two	two	CD
cord-321868-xk4yuibj	158	36	tRNAs	trna	NNS
cord-321868-xk4yuibj	158	37	causes	cause	VBZ
cord-321868-xk4yuibj	158	38	a	a	DT
cord-321868-xk4yuibj	158	39	-1	-1	NN
cord-321868-xk4yuibj	158	40	frameshift	frameshift	NN
cord-321868-xk4yuibj	158	41	(	(	-LRB-
cord-321868-xk4yuibj	159	1	Jacks	Jacks	NNP
cord-321868-xk4yuibj	159	2	et	et	NNP
cord-321868-xk4yuibj	159	3	al	al	NNP
cord-321868-xk4yuibj	159	4	.	.	.
cord-321868-xk4yuibj	160	1	,	,	,
cord-321868-xk4yuibj	160	2	1988a	1988a	CD
cord-321868-xk4yuibj	160	3	(	(	-LRB-
cord-321868-xk4yuibj	160	4	Jacks	Jacks	NNP
cord-321868-xk4yuibj	160	5	et	et	NNP
cord-321868-xk4yuibj	160	6	al	al	NNP
cord-321868-xk4yuibj	160	7	.	.	NNP
cord-321868-xk4yuibj	160	8	,	,	,
cord-321868-xk4yuibj	161	1	,	,	,
cord-321868-xk4yuibj	161	2	1988b	1988b	CD
cord-321868-xk4yuibj	161	3	Wilson	Wilson	NNP
cord-321868-xk4yuibj	161	4	et	et	NNP
cord-321868-xk4yuibj	161	5	al	al	NNP
cord-321868-xk4yuibj	161	6	.	.	NNP
cord-321868-xk4yuibj	161	7	,	,	,
cord-321868-xk4yuibj	161	8	1988	1988	CD
cord-321868-xk4yuibj	161	9	)	)	-RRB-
cord-321868-xk4yuibj	161	10	.	.	.
cord-321868-xk4yuibj	162	1	The	the	DT
cord-321868-xk4yuibj	162	2	model	model	NN
cord-321868-xk4yuibj	162	3	requires	require	VBZ
cord-321868-xk4yuibj	162	4	that	that	IN
cord-321868-xk4yuibj	162	5	both	both	CC
cord-321868-xk4yuibj	162	6	the	the	DT
cord-321868-xk4yuibj	162	7	A	A	NNP
cord-321868-xk4yuibj	162	8	and	and	CC
cord-321868-xk4yuibj	162	9	P	p	NN
cord-321868-xk4yuibj	162	10	sites	site	NNS
cord-321868-xk4yuibj	162	11	be	be	VB
cord-321868-xk4yuibj	162	12	occupied	occupy	VBN
cord-321868-xk4yuibj	162	13	simultaneously	simultaneously	RB
cord-321868-xk4yuibj	162	14	to	to	TO
cord-321868-xk4yuibj	162	15	accomplish	accomplish	VB
cord-321868-xk4yuibj	162	16	the	the	DT
cord-321868-xk4yuibj	162	17	frameshift	frameshift	NN
cord-321868-xk4yuibj	162	18	.	.	.
cord-321868-xk4yuibj	163	1	This	this	DT
cord-321868-xk4yuibj	163	2	could	could	MD
cord-321868-xk4yuibj	163	3	be	be	VB
cord-321868-xk4yuibj	163	4	the	the	DT
cord-321868-xk4yuibj	163	5	case	case	NN
cord-321868-xk4yuibj	163	6	for	for	IN
cord-321868-xk4yuibj	163	7	Ty	Ty	NNP
cord-321868-xk4yuibj	163	8	,	,	,
cord-321868-xk4yuibj	163	9	yet	yet	CC
cord-321868-xk4yuibj	163	10	only	only	RB
cord-321868-xk4yuibj	163	11	the	the	DT
cord-321868-xk4yuibj	163	12	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	163	13	slip	slip	NN
cord-321868-xk4yuibj	163	14	would	would	MD
cord-321868-xk4yuibj	163	15	be	be	VB
cord-321868-xk4yuibj	163	16	in	in	IN
cord-321868-xk4yuibj	163	17	the	the	DT
cord-321868-xk4yuibj	163	18	+	+	NN
cord-321868-xk4yuibj	164	1	l	l	NNP
cord-321868-xk4yuibj	164	2	direction	direction	NN
cord-321868-xk4yuibj	164	3	from	from	IN
cord-321868-xk4yuibj	164	4	CUU	CUU	NNP
cord-321868-xk4yuibj	164	5	-	-	HYPH
cord-321868-xk4yuibj	164	6	AGG	agg	NN
cord-321868-xk4yuibj	164	7	to	to	IN
cord-321868-xk4yuibj	164	8	UUAGGC	UUAGGC	NNP
cord-321868-xk4yuibj	164	9	.	.	.
cord-321868-xk4yuibj	165	1	This	this	DT
cord-321868-xk4yuibj	165	2	would	would	MD
cord-321868-xk4yuibj	165	3	predict	predict	VB
cord-321868-xk4yuibj	165	4	a	a	DT
cord-321868-xk4yuibj	165	5	protein	protein	NN
cord-321868-xk4yuibj	165	6	sequence	sequence	NN
cord-321868-xk4yuibj	165	7	of	of	IN
cord-321868-xk4yuibj	165	8	Leu	Leu	NNP
cord-321868-xk4yuibj	165	9	-	-	HYPH
cord-321868-xk4yuibj	165	10	Arg	Arg	NNP
cord-321868-xk4yuibj	165	11	-	-	:
cord-321868-xk4yuibj	165	12	His	-PRON-	PRP$
cord-321868-xk4yuibj	165	13	through	through	IN
cord-321868-xk4yuibj	165	14	the	the	DT
cord-321868-xk4yuibj	165	15	frameshift	frameshift	NN
cord-321868-xk4yuibj	165	16	site	site	NN
cord-321868-xk4yuibj	165	17	(	(	-LRB-
cord-321868-xk4yuibj	165	18	Figure	Figure	NNP
cord-321868-xk4yuibj	165	19	38	38	CD
cord-321868-xk4yuibj	165	20	)	)	-RRB-
cord-321868-xk4yuibj	165	21	.	.	.
cord-321868-xk4yuibj	166	1	Another	another	DT
cord-321868-xk4yuibj	166	2	model	model	NN
cord-321868-xk4yuibj	166	3	predicts	predict	VBZ
cord-321868-xk4yuibj	166	4	that	that	IN
cord-321868-xk4yuibj	166	5	the	the	DT
cord-321868-xk4yuibj	166	6	ribosome	ribosome	NN
cord-321868-xk4yuibj	166	7	encountering	encounter	VBG
cord-321868-xk4yuibj	166	8	the	the	DT
cord-321868-xk4yuibj	166	9	AGG	agg	NN
cord-321868-xk4yuibj	166	10	codon	codon	NN
cord-321868-xk4yuibj	166	11	pauses	pause	VBZ
cord-321868-xk4yuibj	166	12	because	because	IN
cord-321868-xk4yuibj	166	13	of	of	IN
cord-321868-xk4yuibj	166	14	the	the	DT
cord-321868-xk4yuibj	166	15	low	low	JJ
cord-321868-xk4yuibj	166	16	availability	availability	NN
cord-321868-xk4yuibj	166	17	of	of	IN
cord-321868-xk4yuibj	166	18	tRNA$	trna$	NN
cord-321868-xk4yuibj	166	19	&	&	CC
cord-321868-xk4yuibj	166	20	.	.	.
cord-321868-xk4yuibj	167	1	In	in	IN
cord-321868-xk4yuibj	167	2	this	this	DT
cord-321868-xk4yuibj	167	3	state	state	NN
cord-321868-xk4yuibj	167	4	,	,	,
cord-321868-xk4yuibj	167	5	with	with	IN
cord-321868-xk4yuibj	167	6	peptidyl	peptidyl	NNP
cord-321868-xk4yuibj	167	7	-	-	HYPH
cord-321868-xk4yuibj	167	8	tRNA	tRNA	NNP
cord-321868-xk4yuibj	167	9	&	&	CC
cord-321868-xk4yuibj	167	10	in	in	IN
cord-321868-xk4yuibj	167	11	the	the	DT
cord-321868-xk4yuibj	167	12	P	P	NNP
cord-321868-xk4yuibj	167	13	site	site	NN
cord-321868-xk4yuibj	167	14	and	and	CC
cord-321868-xk4yuibj	167	15	a	a	DT
cord-321868-xk4yuibj	167	16	vacant	vacant	JJ
cord-321868-xk4yuibj	167	17	A	a	DT
cord-321868-xk4yuibj	167	18	site	site	NN
cord-321868-xk4yuibj	167	19	,	,	,
cord-321868-xk4yuibj	167	20	the	the	DT
cord-321868-xk4yuibj	167	21	peptidyl	peptidyl	JJ
cord-321868-xk4yuibj	167	22	-	-	HYPH
cord-321868-xk4yuibj	167	23	tRNA$	trna$	NN
cord-321868-xk4yuibj	167	24	slips	slip	NNS
cord-321868-xk4yuibj	167	25	from	from	IN
cord-321868-xk4yuibj	167	26	the	the	DT
cord-321868-xk4yuibj	167	27	CUU	CUU	NNP
cord-321868-xk4yuibj	167	28	reading	reading	NN
cord-321868-xk4yuibj	167	29	frame	frame	NN
cord-321868-xk4yuibj	167	30	to	to	IN
cord-321868-xk4yuibj	167	31	the	the	DT
cord-321868-xk4yuibj	167	32	UUA	UUA	NNP
cord-321868-xk4yuibj	167	33	(	(	-LRB-
cord-321868-xk4yuibj	167	34	+	+	CC
cord-321868-xk4yuibj	167	35	l	l	NN
cord-321868-xk4yuibj	167	36	)	)	-RRB-
cord-321868-xk4yuibj	167	37	reading	reading	NN
cord-321868-xk4yuibj	167	38	frame	frame	NN
cord-321868-xk4yuibj	167	39	.	.	.
cord-321868-xk4yuibj	168	1	This	this	DT
cord-321868-xk4yuibj	168	2	places	place	VBZ
cord-321868-xk4yuibj	168	3	the	the	DT
cord-321868-xk4yuibj	168	4	GGC	GGC	NNP
cord-321868-xk4yuibj	168	5	(	(	-LRB-
cord-321868-xk4yuibj	168	6	Gly	Gly	NNP
cord-321868-xk4yuibj	168	7	)	)	-RRB-
cord-321868-xk4yuibj	168	8	codon	codon	NN
cord-321868-xk4yuibj	168	9	in	in	IN
cord-321868-xk4yuibj	168	10	the	the	DT
cord-321868-xk4yuibj	168	11	A	A	NNP
cord-321868-xk4yuibj	168	12	site	site	NN
cord-321868-xk4yuibj	168	13	.	.	.
cord-321868-xk4yuibj	169	1	tRNA	tRNA	NNP
cord-321868-xk4yuibj	169	2	&	&	CC
cord-321868-xk4yuibj	169	3	enters	enter	VBZ
cord-321868-xk4yuibj	169	4	the	the	DT
cord-321868-xk4yuibj	169	5	A	A	NNP
cord-321868-xk4yuibj	169	6	site	site	NN
cord-321868-xk4yuibj	169	7	and	and	CC
cord-321868-xk4yuibj	169	8	translation	translation	NN
cord-321868-xk4yuibj	169	9	continues	continue	VBZ
cord-321868-xk4yuibj	169	10	in	in	IN
cord-321868-xk4yuibj	169	11	the	the	DT
cord-321868-xk4yuibj	169	12	+	+	CC
cord-321868-xk4yuibj	169	13	l	l	NN
cord-321868-xk4yuibj	169	14	reading	reading	NN
cord-321868-xk4yuibj	169	15	frame	frame	NN
cord-321868-xk4yuibj	169	16	.	.	.
cord-321868-xk4yuibj	170	1	This	this	DT
cord-321868-xk4yuibj	170	2	model	model	NN
cord-321868-xk4yuibj	170	3	predicts	predict	VBZ
cord-321868-xk4yuibj	170	4	a	a	DT
cord-321868-xk4yuibj	170	5	protein	protein	NN
cord-321868-xk4yuibj	170	6	sequence	sequence	NN
cord-321868-xk4yuibj	170	7	of	of	IN
cord-321868-xk4yuibj	170	8	Leu	Leu	NNP
cord-321868-xk4yuibj	170	9	-	-	HYPH
cord-321868-xk4yuibj	170	10	Gly	Gly	NNP
cord-321868-xk4yuibj	170	11	-	-	HYPH
cord-321868-xk4yuibj	170	12	His	-PRON-	PRP$
cord-321868-xk4yuibj	170	13	(	(	-LRB-
cord-321868-xk4yuibj	170	14	Figure	figure	NN
cord-321868-xk4yuibj	170	15	3A	3a	NN
cord-321868-xk4yuibj	170	16	)	)	-RRB-
cord-321868-xk4yuibj	170	17	.	.	.
cord-321868-xk4yuibj	171	1	To	to	TO
cord-321868-xk4yuibj	171	2	distinguish	distinguish	VB
cord-321868-xk4yuibj	171	3	between	between	IN
cord-321868-xk4yuibj	171	4	the	the	DT
cord-321868-xk4yuibj	171	5	two	two	CD
cord-321868-xk4yuibj	171	6	above	above	IN
cord-321868-xk4yuibj	171	7	scenarios	scenario	NNS
cord-321868-xk4yuibj	171	8	as	as	RB
cord-321868-xk4yuibj	171	9	well	well	RB
cord-321868-xk4yuibj	171	10	as	as	IN
cord-321868-xk4yuibj	171	11	other	other	JJ
cord-321868-xk4yuibj	171	12	models	model	NNS
cord-321868-xk4yuibj	171	13	,	,	,
cord-321868-xk4yuibj	171	14	we	-PRON-	PRP
cord-321868-xk4yuibj	171	15	determined	determine	VBD
cord-321868-xk4yuibj	171	16	the	the	DT
cord-321868-xk4yuibj	171	17	peptide	peptide	NN
cord-321868-xk4yuibj	171	18	sequence	sequence	NN
cord-321868-xk4yuibj	171	19	through	through	IN
cord-321868-xk4yuibj	171	20	the	the	DT
cord-321868-xk4yuibj	171	21	frameshift	frameshift	NN
cord-321868-xk4yuibj	171	22	site	site	NN
cord-321868-xk4yuibj	171	23	.	.	.
cord-321868-xk4yuibj	172	1	The	the	DT
cord-321868-xk4yuibj	172	2	HIS4A::lacZ	HIS4A::lacZ	NNP
cord-321868-xk4yuibj	172	3	fusion	fusion	NN
cord-321868-xk4yuibj	172	4	plasmid	plasmid	NN
cord-321868-xk4yuibj	172	5	p3p	p3p	NN
cord-321868-xk4yuibj	172	6	has	have	VBZ
cord-321868-xk4yuibj	172	7	a	a	DT
cord-321868-xk4yuibj	172	8	BamHl	BamHl	NNP
cord-321868-xk4yuibj	172	9	site	site	NN
cord-321868-xk4yuibj	172	10	incorporated	incorporate	VBN
cord-321868-xk4yuibj	172	11	after	after	IN
cord-321868-xk4yuibj	172	12	the	the	DT
cord-321868-xk4yuibj	172	13	first	first	JJ
cord-321868-xk4yuibj	172	14	two	two	CD
cord-321868-xk4yuibj	172	15	codons	codon	NNS
cord-321868-xk4yuibj	172	16	of	of	IN
cord-321868-xk4yuibj	172	17	the	the	DT
cord-321868-xk4yuibj	172	18	HI.%4	HI.%4	NNP
cord-321868-xk4yuibj	172	19	gene	gene	NN
cord-321868-xk4yuibj	172	20	.	.	.
cord-321868-xk4yuibj	173	1	The	the	DT
cord-321868-xk4yuibj	173	2	construction	construction	NN
cord-321868-xk4yuibj	173	3	is	be	VBZ
cord-321868-xk4yuibj	173	4	described	describe	VBN
cord-321868-xk4yuibj	173	5	in	in	IN
cord-321868-xk4yuibj	173	6	Experimental	Experimental	NNP
cord-321868-xk4yuibj	173	7	Procedures	procedure	NNS
cord-321868-xk4yuibj	173	8	and	and	CC
cord-321868-xk4yuibj	173	9	depicted	depict	VBN
cord-321868-xk4yuibj	173	10	in	in	IN
cord-321868-xk4yuibj	173	11	Figure	Figure	NNP
cord-321868-xk4yuibj	173	12	3	3	CD
cord-321868-xk4yuibj	173	13	.	.	.
cord-321868-xk4yuibj	174	1	The	the	DT
cord-321868-xk4yuibj	174	2	9	9	CD
cord-321868-xk4yuibj	174	3	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	174	4	frameshift	frameshift	NN
cord-321868-xk4yuibj	174	5	site	site	NN
cord-321868-xk4yuibj	174	6	,	,	,
cord-321868-xk4yuibj	174	7	flanked	flank	VBN
cord-321868-xk4yuibj	174	8	by	by	IN
cord-321868-xk4yuibj	174	9	termination	termination	NN
cord-321868-xk4yuibj	174	10	codons	codon	NNS
cord-321868-xk4yuibj	174	11	,	,	,
cord-321868-xk4yuibj	174	12	was	be	VBD
cord-321868-xk4yuibj	174	13	cloned	clone	VBN
cord-321868-xk4yuibj	174	14	at	at	IN
cord-321868-xk4yuibj	174	15	the	the	DT
cord-321868-xk4yuibj	174	16	BamHl	BamHl	NNP
cord-321868-xk4yuibj	174	17	site	site	NN
cord-321868-xk4yuibj	174	18	such	such	JJ
cord-321868-xk4yuibj	174	19	that	that	IN
cord-321868-xk4yuibj	174	20	/acZ	/acZ	NNP
cord-321868-xk4yuibj	174	21	expression	expression	NN
cord-321868-xk4yuibj	174	22	requires	require	VBZ
cord-321868-xk4yuibj	174	23	a	a	DT
cord-321868-xk4yuibj	174	24	+	+	NN
cord-321868-xk4yuibj	175	1	l	l	NN
cord-321868-xk4yuibj	175	2	frameshift	frameshift	NN
cord-321868-xk4yuibj	175	3	within	within	IN
cord-321868-xk4yuibj	175	4	the	the	DT
cord-321868-xk4yuibj	175	5	minimal	minimal	JJ
cord-321868-xk4yuibj	175	6	sequence	sequence	NN
cord-321868-xk4yuibj	175	7	.	.	.
cord-321868-xk4yuibj	176	1	After	after	IN
cord-321868-xk4yuibj	176	2	purification	purification	NN
cord-321868-xk4yuibj	176	3	of	of	IN
cord-321868-xk4yuibj	176	4	the	the	DT
cord-321868-xk4yuibj	176	5	HIS4A::lacZ	HIS4A::lacZ	NNP
cord-321868-xk4yuibj	176	6	fusion	fusion	NN
cord-321868-xk4yuibj	176	7	product	product	NN
cord-321868-xk4yuibj	176	8	,	,	,
cord-321868-xk4yuibj	176	9	the	the	DT
cord-321868-xk4yuibj	176	10	protein	protein	NN
cord-321868-xk4yuibj	176	11	was	be	VBD
cord-321868-xk4yuibj	176	12	subjected	subject	VBN
cord-321868-xk4yuibj	176	13	to	to	IN
cord-321868-xk4yuibj	176	14	14	14	CD
cord-321868-xk4yuibj	176	15	cycles	cycle	NNS
cord-321868-xk4yuibj	176	16	of	of	IN
cord-321868-xk4yuibj	176	17	Edman	Edman	NNP
cord-321868-xk4yuibj	176	18	degradation	degradation	NN
cord-321868-xk4yuibj	176	19	.	.	.
cord-321868-xk4yuibj	177	1	The	the	DT
cord-321868-xk4yuibj	177	2	relevant	relevant	JJ
cord-321868-xk4yuibj	177	3	PTH	PTH	NNP
cord-321868-xk4yuibj	177	4	-	-	HYPH
cord-321868-xk4yuibj	177	5	amino	amino	NN
cord-321868-xk4yuibj	177	6	acids	acid	NNS
cord-321868-xk4yuibj	177	7	through	through	IN
cord-321868-xk4yuibj	177	8	the	the	DT
cord-321868-xk4yuibj	177	9	first	first	JJ
cord-321868-xk4yuibj	177	10	11	11	CD
cord-321868-xk4yuibj	177	11	cycles	cycle	NNS
cord-321868-xk4yuibj	177	12	are	be	VBP
cord-321868-xk4yuibj	177	13	shown	show	VBN
cord-321868-xk4yuibj	177	14	in	in	IN
cord-321868-xk4yuibj	177	15	Figure	Figure	NNP
cord-321868-xk4yuibj	177	16	3C	3c	NN
cord-321868-xk4yuibj	177	17	.	.	.
cord-321868-xk4yuibj	178	1	The	the	DT
cord-321868-xk4yuibj	178	2	data	datum	NNS
cord-321868-xk4yuibj	178	3	clearly	clearly	RB
cord-321868-xk4yuibj	178	4	support	support	VBP
cord-321868-xk4yuibj	178	5	the	the	DT
cord-321868-xk4yuibj	178	6	tRNAktG	tRNAktG	NNP
cord-321868-xk4yuibj	178	7	slippage	slippage	NN
cord-321868-xk4yuibj	178	8	model	model	NN
cord-321868-xk4yuibj	178	9	.	.	.
cord-321868-xk4yuibj	179	1	Glycine	Glycine	NNP
cord-321868-xk4yuibj	179	2	rather	rather	RB
cord-321868-xk4yuibj	179	3	than	than	IN
cord-321868-xk4yuibj	179	4	arginine	arginine	NN
cord-321868-xk4yuibj	179	5	is	be	VBZ
cord-321868-xk4yuibj	179	6	incorporated	incorporate	VBN
cord-321868-xk4yuibj	179	7	after	after	IN
cord-321868-xk4yuibj	179	8	leucine	leucine	NN
cord-321868-xk4yuibj	179	9	,	,	,
cord-321868-xk4yuibj	179	10	indicating	indicate	VBG
cord-321868-xk4yuibj	179	11	that	that	IN
cord-321868-xk4yuibj	179	12	the	the	DT
cord-321868-xk4yuibj	179	13	frameshift	frameshift	NN
cord-321868-xk4yuibj	179	14	event	event	NN
cord-321868-xk4yuibj	179	15	occurs	occur	VBZ
cord-321868-xk4yuibj	179	16	on	on	IN
cord-321868-xk4yuibj	179	17	the	the	DT
cord-321868-xk4yuibj	179	18	CUU	CUU	NNP
cord-321868-xk4yuibj	179	19	leucine	leucine	NN
cord-321868-xk4yuibj	179	20	codon	codon	NN
cord-321868-xk4yuibj	179	21	.	.	.
cord-321868-xk4yuibj	180	1	No	no	DT
cord-321868-xk4yuibj	180	2	significant	significant	JJ
cord-321868-xk4yuibj	180	3	amount	amount	NN
cord-321868-xk4yuibj	180	4	of	of	IN
cord-321868-xk4yuibj	180	5	arginine	arginine	NN
cord-321868-xk4yuibj	180	6	is	be	VBZ
cord-321868-xk4yuibj	180	7	detected	detect	VBN
cord-321868-xk4yuibj	180	8	at	at	IN
cord-321868-xk4yuibj	180	9	cycle	cycle	NN
cord-321868-xk4yuibj	180	10	7	7	CD
cord-321868-xk4yuibj	180	11	,	,	,
cord-321868-xk4yuibj	180	12	ruling	rule	VBG
cord-321868-xk4yuibj	180	13	out	out	RP
cord-321868-xk4yuibj	180	14	a	a	DT
cord-321868-xk4yuibj	180	15	CUU	CUU	NNP
cord-321868-xk4yuibj	180	16	-	-	HYPH
cord-321868-xk4yuibj	180	17	AGG	agg	NN
cord-321868-xk4yuibj	180	18	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	180	19	-	-	HYPH
cord-321868-xk4yuibj	180	20	slippage	slippage	NN
cord-321868-xk4yuibj	180	21	model	model	NN
cord-321868-xk4yuibj	180	22	of	of	IN
cord-321868-xk4yuibj	180	23	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	180	24	.	.	.
cord-321868-xk4yuibj	181	1	These	these	DT
cord-321868-xk4yuibj	181	2	data	datum	NNS
cord-321868-xk4yuibj	181	3	do	do	VBP
cord-321868-xk4yuibj	181	4	not	not	RB
cord-321868-xk4yuibj	181	5	rule	rule	VB
cord-321868-xk4yuibj	181	6	out	out	RP
cord-321868-xk4yuibj	181	7	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	181	8	slippage	slippage	NN
cord-321868-xk4yuibj	181	9	on	on	IN
cord-321868-xk4yuibj	181	10	CUU	CUU	NNP
cord-321868-xk4yuibj	181	11	and	and	CC
cord-321868-xk4yuibj	181	12	the	the	DT
cord-321868-xk4yuibj	181	13	codon	codon	NN
cord-321868-xk4yuibj	181	14	immediately	immediately	RB
cord-321868-xk4yuibj	181	15	upstream	upstream	RB
cord-321868-xk4yuibj	181	16	of	of	IN
cord-321868-xk4yuibj	181	17	it	-PRON-	PRP
cord-321868-xk4yuibj	181	18	;	;	:
cord-321868-xk4yuibj	181	19	this	this	DT
cord-321868-xk4yuibj	181	20	is	be	VBZ
cord-321868-xk4yuibj	181	21	very	very	RB
cord-321868-xk4yuibj	181	22	unlikely	unlikely	JJ
cord-321868-xk4yuibj	181	23	since	since	IN
cord-321868-xk4yuibj	181	24	that	that	DT
cord-321868-xk4yuibj	181	25	codon	codon	NN
cord-321868-xk4yuibj	181	26	is	be	VBZ
cord-321868-xk4yuibj	181	27	not	not	RB
cord-321868-xk4yuibj	181	28	from	from	IN
cord-321868-xk4yuibj	181	29	the	the	DT
cord-321868-xk4yuibj	181	30	Ty	Ty	NNP
cord-321868-xk4yuibj	181	31	overlap	overlap	NN
cord-321868-xk4yuibj	181	32	,	,	,
cord-321868-xk4yuibj	181	33	and	and	CC
cord-321868-xk4yuibj	181	34	can	can	MD
cord-321868-xk4yuibj	181	35	be	be	VB
cord-321868-xk4yuibj	181	36	changed	change	VBN
cord-321868-xk4yuibj	181	37	at	at	IN
cord-321868-xk4yuibj	181	38	any	any	DT
cord-321868-xk4yuibj	181	39	position	position	NN
cord-321868-xk4yuibj	181	40	with	with	IN
cord-321868-xk4yuibj	181	41	no	no	DT
cord-321868-xk4yuibj	181	42	effect	effect	NN
cord-321868-xk4yuibj	181	43	on	on	IN
cord-321868-xk4yuibj	181	44	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	181	45	.	.	.
cord-321868-xk4yuibj	182	1	Therefore	therefore	RB
cord-321868-xk4yuibj	182	2	,	,	,
cord-321868-xk4yuibj	182	3	the	the	DT
cord-321868-xk4yuibj	182	4	most	most	RBS
cord-321868-xk4yuibj	182	5	likely	likely	JJ
cord-321868-xk4yuibj	182	6	model	model	NN
cord-321868-xk4yuibj	182	7	is	be	VBZ
cord-321868-xk4yuibj	182	8	one	one	CD
cord-321868-xk4yuibj	182	9	involving	involve	VBG
cord-321868-xk4yuibj	182	10	slippage	slippage	NN
cord-321868-xk4yuibj	182	11	of	of	IN
cord-321868-xk4yuibj	182	12	a	a	DT
cord-321868-xk4yuibj	182	13	single	single	JJ
cord-321868-xk4yuibj	182	14	tRNA	trna	NN
cord-321868-xk4yuibj	182	15	bound	bind	VBN
cord-321868-xk4yuibj	182	16	to	to	IN
cord-321868-xk4yuibj	182	17	the	the	DT
cord-321868-xk4yuibj	182	18	CUU	CUU	NNP
cord-321868-xk4yuibj	182	19	codon	codon	NN
cord-321868-xk4yuibj	182	20	.	.	.
cord-321868-xk4yuibj	183	1	Occurs	occur	VBZ
cord-321868-xk4yuibj	183	2	When	when	WRB
cord-321868-xk4yuibj	183	3	the	the	DT
cord-321868-xk4yuibj	183	4	AGG	agg	NN
cord-321868-xk4yuibj	183	5	Codon	Codon	NNP
cord-321868-xk4yuibj	183	6	Is	be	VBZ
cord-321868-xk4yuibj	183	7	Unoccupied	unoccupie	VBN
cord-321868-xk4yuibj	183	8	by	by	IN
cord-321868-xk4yuibj	183	9	Its	-PRON-	PRP$
cord-321868-xk4yuibj	183	10	Cognate	Cognate	NNP
cord-321868-xk4yuibj	183	11	tFiNA	tfina	CD
cord-321868-xk4yuibj	184	1	A	a	DT
cord-321868-xk4yuibj	184	2	correlation	correlation	NN
cord-321868-xk4yuibj	184	3	exists	exist	VBZ
cord-321868-xk4yuibj	184	4	between	between	IN
cord-321868-xk4yuibj	184	5	the	the	DT
cord-321868-xk4yuibj	184	6	abundance	abundance	NN
cord-321868-xk4yuibj	184	7	of	of	IN
cord-321868-xk4yuibj	184	8	yeast	yeast	NN
cord-321868-xk4yuibj	184	9	tRNAs	trna	NNS
cord-321868-xk4yuibj	184	10	and	and	CC
cord-321868-xk4yuibj	184	11	the	the	DT
cord-321868-xk4yuibj	184	12	occurrence	occurrence	NN
cord-321868-xk4yuibj	184	13	of	of	IN
cord-321868-xk4yuibj	184	14	their	-PRON-	PRP$
cord-321868-xk4yuibj	184	15	respective	respective	JJ
cord-321868-xk4yuibj	184	16	codons	codon	NNS
cord-321868-xk4yuibj	184	17	(	(	-LRB-
cord-321868-xk4yuibj	184	18	Ikemura	Ikemura	NNP
cord-321868-xk4yuibj	184	19	,	,	,
cord-321868-xk4yuibj	184	20	1982	1982	CD
cord-321868-xk4yuibj	184	21	)	)	-RRB-
cord-321868-xk4yuibj	184	22	.	.	.
cord-321868-xk4yuibj	185	1	The	the	DT
cord-321868-xk4yuibj	185	2	second	second	JJ
cord-321868-xk4yuibj	185	3	codon	codon	NN
cord-321868-xk4yuibj	185	4	(	(	-LRB-
cord-321868-xk4yuibj	185	5	AGG	AGG	NNP
cord-321868-xk4yuibj	185	6	)	)	-RRB-
cord-321868-xk4yuibj	185	7	of	of	IN
cord-321868-xk4yuibj	185	8	the	the	DT
cord-321868-xk4yuibj	185	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	185	10	site	site	NN
cord-321868-xk4yuibj	185	11	is	be	VBZ
cord-321868-xk4yuibj	185	12	recognized	recognize	VBN
cord-321868-xk4yuibj	185	13	by	by	IN
cord-321868-xk4yuibj	185	14	a	a	DT
cord-321868-xk4yuibj	185	15	low	low	JJ
cord-321868-xk4yuibj	185	16	-	-	HYPH
cord-321868-xk4yuibj	185	17	abundance	abundance	NN
cord-321868-xk4yuibj	185	18	tRNA	trna	NN
cord-321868-xk4yuibj	185	19	encoded	encode	VBN
cord-321868-xk4yuibj	185	20	by	by	IN
cord-321868-xk4yuibj	185	21	a	a	DT
cord-321868-xk4yuibj	185	22	single	single	JJ
cord-321868-xk4yuibj	185	23	gene	gene	NN
cord-321868-xk4yuibj	185	24	.	.	.
cord-321868-xk4yuibj	186	1	As	as	IN
cord-321868-xk4yuibj	186	2	expected	expect	VBN
cord-321868-xk4yuibj	186	3	,	,	,
cord-321868-xk4yuibj	186	4	the	the	DT
cord-321868-xk4yuibj	186	5	codon	codon	NN
cord-321868-xk4yuibj	186	6	AGG	AGG	NNP
cord-321868-xk4yuibj	186	7	is	be	VBZ
cord-321868-xk4yuibj	186	8	rare	rare	JJ
cord-321868-xk4yuibj	186	9	in	in	IN
cord-321868-xk4yuibj	186	10	yeast	yeast	NN
cord-321868-xk4yuibj	186	11	genes	gene	NNS
cord-321868-xk4yuibj	186	12	(	(	-LRB-
cord-321868-xk4yuibj	186	13	Aota	Aota	NNP
cord-321868-xk4yuibj	186	14	et	et	FW
cord-321868-xk4yuibj	186	15	al	al	NNP
cord-321868-xk4yuibj	186	16	.	.	NNP
cord-321868-xk4yuibj	186	17	,	,	,
cord-321868-xk4yuibj	186	18	1988	1988	CD
cord-321868-xk4yuibj	186	19	)	)	-RRB-
cord-321868-xk4yuibj	186	20	.	.	.
cord-321868-xk4yuibj	187	1	The	the	DT
cord-321868-xk4yuibj	187	2	fact	fact	NN
cord-321868-xk4yuibj	187	3	that	that	IN
cord-321868-xk4yuibj	187	4	the	the	DT
cord-321868-xk4yuibj	187	5	rate	rate	NN
cord-321868-xk4yuibj	187	6	of	of	IN
cord-321868-xk4yuibj	187	7	aminoacyl	aminoacyl	NNP
cord-321868-xk4yuibj	187	8	-	-	HYPH
cord-321868-xk4yuibj	187	9	tRNA	trna	NN
cord-321868-xk4yuibj	187	10	binding	bind	VBG
cord-321868-xk4yuibj	187	11	to	to	IN
cord-321868-xk4yuibj	187	12	the	the	DT
cord-321868-xk4yuibj	187	13	ribosomal	ribosomal	NN
cord-321868-xk4yuibj	187	14	A	a	DT
cord-321868-xk4yuibj	187	15	site	site	NN
cord-321868-xk4yuibj	187	16	is	be	VBZ
cord-321868-xk4yuibj	187	17	proportional	proportional	JJ
cord-321868-xk4yuibj	187	18	to	to	IN
cord-321868-xk4yuibj	187	19	its	-PRON-	PRP$
cord-321868-xk4yuibj	187	20	concentration	concentration	NN
cord-321868-xk4yuibj	187	21	(	(	-LRB-
cord-321868-xk4yuibj	187	22	Thompson	Thompson	NNP
cord-321868-xk4yuibj	187	23	et	et	NNP
cord-321868-xk4yuibj	187	24	al	al	NNP
cord-321868-xk4yuibj	187	25	.	.	NNP
cord-321868-xk4yuibj	187	26	,	,	,
cord-321868-xk4yuibj	187	27	1980	1980	CD
cord-321868-xk4yuibj	187	28	)	)	-RRB-
cord-321868-xk4yuibj	187	29	has	have	VBZ
cord-321868-xk4yuibj	187	30	been	be	VBN
cord-321868-xk4yuibj	187	31	taken	take	VBN
cord-321868-xk4yuibj	187	32	to	to	TO
cord-321868-xk4yuibj	187	33	mean	mean	VB
cord-321868-xk4yuibj	187	34	that	that	IN
cord-321868-xk4yuibj	187	35	codons	codon	NNS
cord-321868-xk4yuibj	187	36	recognized	recognize	VBN
cord-321868-xk4yuibj	187	37	by	by	IN
cord-321868-xk4yuibj	187	38	abundant	abundant	JJ
cord-321868-xk4yuibj	187	39	tRNAs	trna	NNS
cord-321868-xk4yuibj	187	40	are	be	VBP
cord-321868-xk4yuibj	187	41	decoded	decode	VBN
cord-321868-xk4yuibj	187	42	quickly	quickly	RB
cord-321868-xk4yuibj	187	43	,	,	,
cord-321868-xk4yuibj	187	44	while	while	IN
cord-321868-xk4yuibj	187	45	codons	codon	NNS
cord-321868-xk4yuibj	187	46	recognized	recognize	VBN
cord-321868-xk4yuibj	187	47	by	by	IN
cord-321868-xk4yuibj	187	48	nonabundant	nonabundant	JJ
cord-321868-xk4yuibj	187	49	tRNAs	trna	NNS
cord-321868-xk4yuibj	187	50	are	be	VBP
cord-321868-xk4yuibj	187	51	decoded	decode	VBN
cord-321868-xk4yuibj	187	52	slowly	slowly	RB
cord-321868-xk4yuibj	187	53	.	.	.
cord-321868-xk4yuibj	188	1	Recent	recent	JJ
cord-321868-xk4yuibj	188	2	evidence	evidence	NN
cord-321868-xk4yuibj	188	3	suggests	suggest	VBZ
cord-321868-xk4yuibj	188	4	that	that	IN
cord-321868-xk4yuibj	188	5	translation	translation	NN
cord-321868-xk4yuibj	188	6	rate	rate	NN
cord-321868-xk4yuibj	188	7	is	be	VBZ
cord-321868-xk4yuibj	188	8	not	not	RB
cord-321868-xk4yuibj	188	9	strictly	strictly	RB
cord-321868-xk4yuibj	188	10	correlated	correlate	VBN
cord-321868-xk4yuibj	188	11	with	with	IN
cord-321868-xk4yuibj	188	12	tRNA	trna	NN
cord-321868-xk4yuibj	188	13	concentration	concentration	NN
cord-321868-xk4yuibj	188	14	,	,	,
cord-321868-xk4yuibj	188	15	since	since	IN
cord-321868-xk4yuibj	188	16	some	some	DT
cord-321868-xk4yuibj	188	17	nonabundant	nonabundant	JJ
cord-321868-xk4yuibj	188	18	tRNAs	trna	NNS
cord-321868-xk4yuibj	188	19	are	be	VBP
cord-321868-xk4yuibj	188	20	decoded	decode	VBN
cord-321868-xk4yuibj	188	21	more	more	RBR
cord-321868-xk4yuibj	188	22	quickly	quickly	RB
cord-321868-xk4yuibj	188	23	than	than	IN
cord-321868-xk4yuibj	188	24	some	some	DT
cord-321868-xk4yuibj	188	25	much	much	RB
cord-321868-xk4yuibj	188	26	more	more	RBR
cord-321868-xk4yuibj	188	27	abundant	abundant	JJ
cord-321868-xk4yuibj	188	28	tRNAs	trna	NNS
cord-321868-xk4yuibj	189	1	(	(	-LRB-
cord-321868-xk4yuibj	189	2	Bonekamp	Bonekamp	NNP
cord-321868-xk4yuibj	189	3	et	et	NNP
cord-321868-xk4yuibj	189	4	al	al	NNP
cord-321868-xk4yuibj	189	5	.	.	NNP
cord-321868-xk4yuibj	189	6	,	,	,
cord-321868-xk4yuibj	189	7	1989	1989	CD
cord-321868-xk4yuibj	189	8	)	)	-RRB-
cord-321868-xk4yuibj	189	9	.	.	.
cord-321868-xk4yuibj	190	1	Though	though	IN
cord-321868-xk4yuibj	190	2	the	the	DT
cord-321868-xk4yuibj	190	3	rule	rule	NN
cord-321868-xk4yuibj	190	4	that	that	IN
cord-321868-xk4yuibj	190	5	all	all	DT
cord-321868-xk4yuibj	190	6	low	low	JJ
cord-321868-xk4yuibj	190	7	-	-	HYPH
cord-321868-xk4yuibj	190	8	abundance	abundance	NN
cord-321868-xk4yuibj	190	9	tRNAs	trna	NNS
cord-321868-xk4yuibj	190	10	decode	decode	VBP
cord-321868-xk4yuibj	190	11	slowly	slowly	RB
cord-321868-xk4yuibj	190	12	may	may	MD
cord-321868-xk4yuibj	190	13	not	not	RB
cord-321868-xk4yuibj	190	14	be	be	VB
cord-321868-xk4yuibj	190	15	universal	universal	JJ
cord-321868-xk4yuibj	190	16	,	,	,
cord-321868-xk4yuibj	190	17	it	-PRON-	PRP
cord-321868-xk4yuibj	190	18	is	be	VBZ
cord-321868-xk4yuibj	190	19	true	true	JJ
cord-321868-xk4yuibj	190	20	that	that	IN
cord-321868-xk4yuibj	190	21	some	some	DT
cord-321868-xk4yuibj	190	22	codons	codon	NNS
cord-321868-xk4yuibj	190	23	are	be	VBP
cord-321868-xk4yuibj	190	24	very	very	RB
cord-321868-xk4yuibj	190	25	slowly	slowly	RB
cord-321868-xk4yuibj	190	26	decoded	decode	VBN
cord-321868-xk4yuibj	190	27	.	.	.
cord-321868-xk4yuibj	191	1	Interestingly	interestingly	RB
cord-321868-xk4yuibj	191	2	,	,	,
cord-321868-xk4yuibj	191	3	the	the	DT
cord-321868-xk4yuibj	191	4	tRNA&u	tRNA&u	NNP
cord-321868-xk4yuibj	191	5	of	of	IN
cord-321868-xk4yuibj	191	6	E.	E.	NNP
cord-321868-xk4yuibj	191	7	coli	coli	NNS
cord-321868-xk4yuibj	191	8	,	,	,
cord-321868-xk4yuibj	191	9	which	which	WDT
cord-321868-xk4yuibj	191	10	is	be	VBZ
cord-321868-xk4yuibj	191	11	also	also	RB
cord-321868-xk4yuibj	191	12	a	a	DT
cord-321868-xk4yuibj	191	13	rare	rare	JJ
cord-321868-xk4yuibj	191	14	tRNA	trna	NN
cord-321868-xk4yuibj	191	15	,	,	,
cord-321868-xk4yuibj	191	16	has	have	VBZ
cord-321868-xk4yuibj	191	17	a	a	DT
cord-321868-xk4yuibj	191	18	low	low	JJ
cord-321868-xk4yuibj	191	19	intrinsic	intrinsic	JJ
cord-321868-xk4yuibj	191	20	decoding	decoding	NN
cord-321868-xk4yuibj	191	21	rate	rate	NN
cord-321868-xk4yuibj	191	22	(	(	-LRB-
cord-321868-xk4yuibj	191	23	Bonekamp	Bonekamp	NNP
cord-321868-xk4yuibj	191	24	and	and	CC
cord-321868-xk4yuibj	191	25	Jensen	Jensen	NNP
cord-321868-xk4yuibj	191	26	,	,	,
cord-321868-xk4yuibj	191	27	1988	1988	CD
cord-321868-xk4yuibj	191	28	)	)	-RRB-
cord-321868-xk4yuibj	191	29	.	.	.
cord-321868-xk4yuibj	192	1	It	-PRON-	PRP
cord-321868-xk4yuibj	192	2	is	be	VBZ
cord-321868-xk4yuibj	192	3	possible	possible	JJ
cord-321868-xk4yuibj	192	4	that	that	IN
cord-321868-xk4yuibj	192	5	the	the	DT
cord-321868-xk4yuibj	192	6	very	very	RB
cord-321868-xk4yuibj	192	7	low	low	JJ
cord-321868-xk4yuibj	192	8	abundance	abundance	NN
cord-321868-xk4yuibj	192	9	of	of	IN
cord-321868-xk4yuibj	192	10	tRNA@u	tRNA@u	NNP
cord-321868-xk4yuibj	192	11	is	be	VBZ
cord-321868-xk4yuibj	192	12	necessary	necessary	JJ
cord-321868-xk4yuibj	192	13	to	to	TO
cord-321868-xk4yuibj	192	14	promote	promote	VB
cord-321868-xk4yuibj	192	15	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	192	16	by	by	IN
cord-321868-xk4yuibj	192	17	causing	cause	VBG
cord-321868-xk4yuibj	192	18	a	a	DT
cord-321868-xk4yuibj	192	19	translational	translational	JJ
cord-321868-xk4yuibj	192	20	pause	pause	NN
cord-321868-xk4yuibj	192	21	analogous	analogous	JJ
cord-321868-xk4yuibj	192	22	to	to	IN
cord-321868-xk4yuibj	192	23	the	the	DT
cord-321868-xk4yuibj	192	24	function	function	NN
cord-321868-xk4yuibj	192	25	of	of	IN
cord-321868-xk4yuibj	192	26	the	the	DT
cord-321868-xk4yuibj	192	27	nonsense	nonsense	NN
cord-321868-xk4yuibj	192	28	codon	codon	NN
cord-321868-xk4yuibj	192	29	and	and	CC
cord-321868-xk4yuibj	192	30	"	"	``
cord-321868-xk4yuibj	192	31	hungry"codons	hungry"codon	NNS
cord-321868-xk4yuibj	192	32	in	in	IN
cord-321868-xk4yuibj	192	33	E.	E.	NNP
cord-321868-xk4yuibj	192	34	coli	coli	NNS
cord-321868-xk4yuibj	193	1	frame-	frame-	NNP
cord-321868-xk4yuibj	193	2	shifts	shift	NNS
cord-321868-xk4yuibj	194	1	(	(	-LRB-
cord-321868-xk4yuibj	194	2	Weiss	Weiss	NNP
cord-321868-xk4yuibj	194	3	et	et	NNP
cord-321868-xk4yuibj	194	4	al	al	NNP
cord-321868-xk4yuibj	194	5	.	.	NNP
cord-321868-xk4yuibj	194	6	,	,	,
cord-321868-xk4yuibj	194	7	1987	1987	CD
cord-321868-xk4yuibj	194	8	.	.	.
cord-321868-xk4yuibj	195	1	If	if	IN
cord-321868-xk4yuibj	195	2	this	this	DT
cord-321868-xk4yuibj	195	3	is	be	VBZ
cord-321868-xk4yuibj	195	4	true	true	JJ
cord-321868-xk4yuibj	195	5	,	,	,
cord-321868-xk4yuibj	195	6	then	then	RB
cord-321868-xk4yuibj	195	7	it	-PRON-	PRP
cord-321868-xk4yuibj	195	8	may	may	MD
cord-321868-xk4yuibj	195	9	be	be	VB
cord-321868-xk4yuibj	195	10	possible	possible	JJ
cord-321868-xk4yuibj	195	11	to	to	TO
cord-321868-xk4yuibj	195	12	modulate	modulate	VB
cord-321868-xk4yuibj	195	13	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	195	14	by	by	IN
cord-321868-xk4yuibj	195	15	modulating	modulate	VBG
cord-321868-xk4yuibj	195	16	the	the	DT
cord-321868-xk4yuibj	195	17	amount	amount	NN
cord-321868-xk4yuibj	195	18	of	of	IN
cord-321868-xk4yuibj	195	19	the	the	DT
cord-321868-xk4yuibj	195	20	rare	rare	JJ
cord-321868-xk4yuibj	195	21	tRNA	tRNA	NNP
cord-321868-xk4yuibj	195	22	.	.	.
cord-321868-xk4yuibj	196	1	In	in	IN
cord-321868-xk4yuibj	196	2	particular	particular	JJ
cord-321868-xk4yuibj	196	3	,	,	,
cord-321868-xk4yuibj	196	4	increasing	increase	VBG
cord-321868-xk4yuibj	196	5	the	the	DT
cord-321868-xk4yuibj	196	6	in	in	IN
cord-321868-xk4yuibj	196	7	vivo	vivo	NN
cord-321868-xk4yuibj	196	8	concentration	concentration	NN
cord-321868-xk4yuibj	196	9	of	of	IN
cord-321868-xk4yuibj	196	10	the	the	DT
cord-321868-xk4yuibj	196	11	tRNA	trna	NN
cord-321868-xk4yuibj	196	12	should	should	MD
cord-321868-xk4yuibj	196	13	decrease	decrease	VB
cord-321868-xk4yuibj	196	14	the	the	DT
cord-321868-xk4yuibj	196	15	putative	putative	JJ
cord-321868-xk4yuibj	196	16	pause	pause	NN
cord-321868-xk4yuibj	196	17	,	,	,
cord-321868-xk4yuibj	196	18	and	and	CC
cord-321868-xk4yuibj	196	19	thus	thus	RB
cord-321868-xk4yuibj	196	20	decrease	decrease	VB
cord-321868-xk4yuibj	196	21	the	the	DT
cord-321868-xk4yuibj	196	22	rate	rate	NN
cord-321868-xk4yuibj	196	23	of	of	IN
cord-321868-xk4yuibj	196	24	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	196	25	.	.	.
cord-321868-xk4yuibj	197	1	The	the	DT
cord-321868-xk4yuibj	197	2	gene	gene	NN
cord-321868-xk4yuibj	197	3	for	for	IN
cord-321868-xk4yuibj	197	4	tRNA@u	tRNA@u	NNP
cord-321868-xk4yuibj	197	5	was	be	VBD
cord-321868-xk4yuibj	197	6	cloned	clone	VBN
cord-321868-xk4yuibj	197	7	onto	onto	IN
cord-321868-xk4yuibj	197	8	a	a	DT
cord-321868-xk4yuibj	197	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	197	10	reporter	reporter	NN
cord-321868-xk4yuibj	197	11	plasmid	plasmid	NN
cord-321868-xk4yuibj	197	12	,	,	,
cord-321868-xk4yuibj	197	13	pMBS&SmerWT	pmbs&smerwt	XX
cord-321868-xk4yuibj	197	14	,	,	,
cord-321868-xk4yuibj	197	15	as	as	IN
cord-321868-xk4yuibj	197	16	described	describe	VBN
cord-321868-xk4yuibj	197	17	in	in	IN
cord-321868-xk4yuibj	197	18	Experimental	Experimental	NNP
cord-321868-xk4yuibj	197	19	Procedures	procedure	NNS
cord-321868-xk4yuibj	197	20	.	.	.
cord-321868-xk4yuibj	198	1	The	the	DT
cord-321868-xk4yuibj	198	2	copy	copy	NN
cord-321868-xk4yuibj	198	3	number	number	NN
cord-321868-xk4yuibj	198	4	of	of	IN
cord-321868-xk4yuibj	198	5	this	this	DT
cord-321868-xk4yuibj	198	6	plasmid	plasmid	NN
cord-321868-xk4yuibj	198	7	is	be	VBZ
cord-321868-xk4yuibj	198	8	approximately	approximately	RB
cord-321868-xk4yuibj	198	9	four	four	CD
cord-321868-xk4yuibj	198	10	per	per	IN
cord-321868-xk4yuibj	198	11	cell	cell	NN
cord-321868-xk4yuibj	198	12	,	,	,
cord-321868-xk4yuibj	198	13	increasing	increase	VBG
cord-321868-xk4yuibj	198	14	the	the	DT
cord-321868-xk4yuibj	198	15	total	total	JJ
cord-321868-xk4yuibj	198	16	number	number	NN
cord-321868-xk4yuibj	198	17	of	of	IN
cord-321868-xk4yuibj	198	18	copies	copy	NNS
cord-321868-xk4yuibj	198	19	of	of	IN
cord-321868-xk4yuibj	198	20	the	the	DT
cord-321868-xk4yuibj	198	21	tRNA$	tRNA$	NNP
cord-321868-xk4yuibj	198	22	!	!	.
cord-321868-xk4yuibj	198	23	&	&	CC
cord-321868-xk4yuibj	198	24	gene	gene	NN
cord-321868-xk4yuibj	198	25	to	to	IN
cord-321868-xk4yuibj	198	26	five	five	CD
cord-321868-xk4yuibj	198	27	per	per	IN
cord-321868-xk4yuibj	198	28	cell	cell	NN
cord-321868-xk4yuibj	198	29	(	(	-LRB-
cord-321868-xk4yuibj	198	30	including	include	VBG
cord-321868-xk4yuibj	198	31	the	the	DT
cord-321868-xk4yuibj	198	32	one	one	CD
cord-321868-xk4yuibj	198	33	endogenous	endogenous	JJ
cord-321868-xk4yuibj	198	34	copy	copy	NN
cord-321868-xk4yuibj	198	35	)	)	-RRB-
cord-321868-xk4yuibj	198	36	.	.	.
cord-321868-xk4yuibj	199	1	The	the	DT
cord-321868-xk4yuibj	199	2	plasmid	plasmid	NN
cord-321868-xk4yuibj	199	3	contains	contain	VBZ
cord-321868-xk4yuibj	199	4	the	the	DT
cord-321868-xk4yuibj	199	5	H	H	NNP
cord-321868-xk4yuibj	199	6	/	/	SYM
cord-321868-xk4yuibj	199	7	S4A-9	s4a-9	JJ
cord-321868-xk4yuibj	199	8	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	199	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	199	10	site	site	NN
cord-321868-xk4yuibj	199	11	-	-	HYPH
cord-321868-xk4yuibj	199	12	lac	lac	NN
cord-321868-xk4yuibj	199	13	;	;	:
cord-321868-xk4yuibj	199	14	!	!	.
cord-321868-xk4yuibj	200	1	reporter	reporter	NN
cord-321868-xk4yuibj	200	2	gene	gene	NN
cord-321868-xk4yuibj	200	3	,	,	,
cord-321868-xk4yuibj	200	4	which	which	WDT
cord-321868-xk4yuibj	200	5	normally	normally	RB
cord-321868-xk4yuibj	200	6	shows	show	VBZ
cord-321868-xk4yuibj	200	7	40	40	CD
cord-321868-xk4yuibj	200	8	%	%	NN
cord-321868-xk4yuibj	200	9	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	200	10	(	(	-LRB-
cord-321868-xk4yuibj	200	11	Table	table	NN
cord-321868-xk4yuibj	200	12	3	3	CD
cord-321868-xk4yuibj	200	13	)	)	-RRB-
cord-321868-xk4yuibj	200	14	.	.	.
cord-321868-xk4yuibj	201	1	The	the	DT
cord-321868-xk4yuibj	201	2	5-fold	5-fold	CD
cord-321868-xk4yuibj	201	3	increase	increase	NN
cord-321868-xk4yuibj	201	4	in	in	IN
cord-321868-xk4yuibj	201	5	copy	copy	NN
cord-321868-xk4yuibj	201	6	number	number	NN
cord-321868-xk4yuibj	201	7	of	of	IN
cord-321868-xk4yuibj	201	8	the	the	DT
cord-321868-xk4yuibj	201	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	201	10	&	&	CC
cord-321868-xk4yuibj	201	11	severely	severely	RB
cord-321868-xk4yuibj	201	12	inhibited	inhibited	JJ
cord-321868-xk4yuibj	201	13	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	201	14	(	(	-LRB-
cord-321868-xk4yuibj	201	15	Table	Table	NNP
cord-321868-xk4yuibj	201	16	3	3	CD
cord-321868-xk4yuibj	201	17	)	)	-RRB-
cord-321868-xk4yuibj	201	18	.	.	.
cord-321868-xk4yuibj	202	1	The	the	DT
cord-321868-xk4yuibj	202	2	fact	fact	NN
cord-321868-xk4yuibj	202	3	that	that	IN
cord-321868-xk4yuibj	202	4	increasing	increase	VBG
cord-321868-xk4yuibj	202	5	the	the	DT
cord-321868-xk4yuibj	202	6	concentration	concentration	NN
cord-321868-xk4yuibj	202	7	of	of	IN
cord-321868-xk4yuibj	202	8	tRNA	tRNA	NNP
cord-321868-xk4yuibj	202	9	&	&	CC
cord-321868-xk4yuibj	202	10	causes	cause	VBZ
cord-321868-xk4yuibj	202	11	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	202	12	to	to	TO
cord-321868-xk4yuibj	202	13	decrease	decrease	VB
cord-321868-xk4yuibj	202	14	is	be	VBZ
cord-321868-xk4yuibj	202	15	incompatible	incompatible	JJ
cord-321868-xk4yuibj	202	16	with	with	IN
cord-321868-xk4yuibj	202	17	any	any	DT
cord-321868-xk4yuibj	202	18	model	model	NN
cord-321868-xk4yuibj	202	19	in	in	IN
cord-321868-xk4yuibj	202	20	which	which	WDT
cord-321868-xk4yuibj	202	21	the	the	DT
cord-321868-xk4yuibj	202	22	frameshift	frameshift	NN
cord-321868-xk4yuibj	202	23	event	event	NN
cord-321868-xk4yuibj	202	24	is	be	VBZ
cord-321868-xk4yuibj	202	25	stimulated	stimulate	VBN
cord-321868-xk4yuibj	202	26	in	in	IN
cord-321868-xk4yuibj	202	27	part	part	NN
cord-321868-xk4yuibj	202	28	by	by	IN
cord-321868-xk4yuibj	202	29	binding	bind	VBG
cord-321868-xk4yuibj	202	30	of	of	IN
cord-321868-xk4yuibj	202	31	tRNA	tRNA	NNP
cord-321868-xk4yuibj	202	32	&	&	CC
cord-321868-xk4yuibj	202	33	to	to	IN
cord-321868-xk4yuibj	202	34	the	the	DT
cord-321868-xk4yuibj	202	35	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	202	36	A	a	DT
cord-321868-xk4yuibj	202	37	site	site	NN
cord-321868-xk4yuibj	202	38	.	.	.
cord-321868-xk4yuibj	203	1	Rather	rather	RB
cord-321868-xk4yuibj	203	2	,	,	,
cord-321868-xk4yuibj	203	3	tRNA	tRNA	NNP
cord-321868-xk4yuibj	203	4	&	&	CC
cord-321868-xk4yuibj	203	5	must	must	MD
cord-321868-xk4yuibj	203	6	"	"	``
cord-321868-xk4yuibj	203	7	act	act	VB
cord-321868-xk4yuibj	203	8	"	"	''
cord-321868-xk4yuibj	203	9	by	by	IN
cord-321868-xk4yuibj	203	10	being	be	VBG
cord-321868-xk4yuibj	203	11	absent	absent	JJ
cord-321868-xk4yuibj	203	12	from	from	IN
cord-321868-xk4yuibj	203	13	the	the	DT
cord-321868-xk4yuibj	203	14	ribosome	ribosome	NN
cord-321868-xk4yuibj	203	15	since	since	IN
cord-321868-xk4yuibj	203	16	increasing	increase	VBG
cord-321868-xk4yuibj	203	17	its	-PRON-	PRP$
cord-321868-xk4yuibj	203	18	ability	ability	NN
cord-321868-xk4yuibj	203	19	to	to	TO
cord-321868-xk4yuibj	203	20	occupy	occupy	VB
cord-321868-xk4yuibj	203	21	the	the	DT
cord-321868-xk4yuibj	203	22	A	A	NNP
cord-321868-xk4yuibj	203	23	site	site	NN
cord-321868-xk4yuibj	203	24	has	have	VBZ
cord-321868-xk4yuibj	203	25	a	a	DT
cord-321868-xk4yuibj	203	26	negative	negative	JJ
cord-321868-xk4yuibj	203	27	effect	effect	NN
cord-321868-xk4yuibj	203	28	on	on	IN
cord-321868-xk4yuibj	203	29	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	203	30	.	.	.
cord-321868-xk4yuibj	204	1	We	-PRON-	PRP
cord-321868-xk4yuibj	204	2	conclude	conclude	VBP
cord-321868-xk4yuibj	204	3	that	that	IN
cord-321868-xk4yuibj	204	4	competition	competition	NN
cord-321868-xk4yuibj	204	5	for	for	IN
cord-321868-xk4yuibj	204	6	the	the	DT
cord-321868-xk4yuibj	204	7	rare	rare	NNP
cord-321868-xk4yuibj	204	8	tRNA	tRNA	NNP
cord-321868-xk4yuibj	204	9	&	&	CC
cord-321868-xk4yuibj	204	10	induces	induce	VBZ
cord-321868-xk4yuibj	204	11	a	a	DT
cord-321868-xk4yuibj	204	12	translational	translational	JJ
cord-321868-xk4yuibj	204	13	pause	pause	NN
cord-321868-xk4yuibj	204	14	that	that	WDT
cord-321868-xk4yuibj	204	15	is	be	VBZ
cord-321868-xk4yuibj	204	16	essential	essential	JJ
cord-321868-xk4yuibj	204	17	for	for	IN
cord-321868-xk4yuibj	204	18	the	the	DT
cord-321868-xk4yuibj	204	19	frameshift	frameshift	NN
cord-321868-xk4yuibj	204	20	event	event	NN
cord-321868-xk4yuibj	204	21	and	and	CC
cord-321868-xk4yuibj	204	22	that	that	IN
cord-321868-xk4yuibj	204	23	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	204	24	occurs	occur	VBZ
cord-321868-xk4yuibj	204	25	when	when	WRB
cord-321868-xk4yuibj	204	26	the	the	DT
cord-321868-xk4yuibj	204	27	ribosomal	ribosomal	NN
cord-321868-xk4yuibj	204	28	A	a	DT
cord-321868-xk4yuibj	204	29	site	site	NN
cord-321868-xk4yuibj	204	30	is	be	VBZ
cord-321868-xk4yuibj	204	31	unoccupied	unoccupied	JJ
cord-321868-xk4yuibj	204	32	.	.	.
cord-321868-xk4yuibj	205	1	Depends	depend	VBZ
cord-321868-xk4yuibj	205	2	upon	upon	IN
cord-321868-xk4yuibj	205	3	tRNA	trna	NN
cord-321868-xk4yuibj	205	4	Slippage	slippage	NN
cord-321868-xk4yuibj	205	5	between	between	IN
cord-321868-xk4yuibj	205	6	the	the	DT
cord-321868-xk4yuibj	205	7	CUU	CUU	NNP
cord-321868-xk4yuibj	205	8	and	and	CC
cord-321868-xk4yuibj	205	9	UUA	UUA	NNP
cord-321868-xk4yuibj	205	10	Leucine	Leucine	NNP
cord-321868-xk4yuibj	205	11	Codons	Codons	NNPS
cord-321868-xk4yuibj	206	1	The	the	DT
cord-321868-xk4yuibj	206	2	missense	missense	NN
cord-321868-xk4yuibj	206	3	mutagenesis	mutagenesis	NN
cord-321868-xk4yuibj	206	4	data	datum	NNS
cord-321868-xk4yuibj	206	5	demonstrate	demonstrate	VBP
cord-321868-xk4yuibj	206	6	that	that	IN
cord-321868-xk4yuibj	206	7	the	the	DT
cord-321868-xk4yuibj	206	8	CUU	CUU	NNP
cord-321868-xk4yuibj	206	9	codon	codon	NN
cord-321868-xk4yuibj	206	10	is	be	VBZ
cord-321868-xk4yuibj	206	11	essential	essential	JJ
cord-321868-xk4yuibj	206	12	for	for	IN
cord-321868-xk4yuibj	206	13	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	206	14	(	(	-LRB-
cord-321868-xk4yuibj	206	15	Figure	figure	NN
cord-321868-xk4yuibj	206	16	2	2	CD
cord-321868-xk4yuibj	206	17	)	)	-RRB-
cord-321868-xk4yuibj	206	18	.	.	.
cord-321868-xk4yuibj	207	1	We	-PRON-	PRP
cord-321868-xk4yuibj	207	2	wanted	want	VBD
cord-321868-xk4yuibj	207	3	to	to	TO
cord-321868-xk4yuibj	207	4	test	test	VB
cord-321868-xk4yuibj	207	5	directly	directly	RB
cord-321868-xk4yuibj	207	6	if	if	IN
cord-321868-xk4yuibj	207	7	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	207	8	depended	depend	VBD
cord-321868-xk4yuibj	207	9	upon	upon	IN
cord-321868-xk4yuibj	207	10	frame	frame	NN
cord-321868-xk4yuibj	207	11	slippage	slippage	NN
cord-321868-xk4yuibj	207	12	by	by	IN
cord-321868-xk4yuibj	207	13	a	a	DT
cord-321868-xk4yuibj	207	14	peptidyl	peptidyl	NN
cord-321868-xk4yuibj	207	15	-	-	:
cord-321868-xk4yuibj	207	16	tRNALeU.	trnaleu.	NN
cord-321868-xk4yuibj	208	1	If	if	IN
cord-321868-xk4yuibj	208	2	tRNAkG	tRNAkG	NNP
cord-321868-xk4yuibj	208	3	promotes	promote	VBZ
cord-321868-xk4yuibj	208	4	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	208	5	by	by	IN
cord-321868-xk4yuibj	208	6	frame	frame	NN
cord-321868-xk4yuibj	208	7	slippage	slippage	NN
cord-321868-xk4yuibj	208	8	,	,	,
cord-321868-xk4yuibj	208	9	then	then	RB
cord-321868-xk4yuibj	208	10	the	the	DT
cord-321868-xk4yuibj	208	11	rate	rate	NN
cord-321868-xk4yuibj	208	12	of	of	IN
cord-321868-xk4yuibj	208	13	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	208	14	should	should	MD
cord-321868-xk4yuibj	208	15	be	be	VB
cord-321868-xk4yuibj	208	16	directly	directly	RB
cord-321868-xk4yuibj	208	17	related	relate	VBN
cord-321868-xk4yuibj	208	18	to	to	IN
cord-321868-xk4yuibj	208	19	the	the	DT
cord-321868-xk4yuibj	208	20	frequency	frequency	NN
cord-321868-xk4yuibj	208	21	that	that	IN
cord-321868-xk4yuibj	208	22	that	that	IN
cord-321868-xk4yuibj	208	23	tRNA	tRNA	NNP
cord-321868-xk4yuibj	208	24	is	be	VBZ
cord-321868-xk4yuibj	208	25	used	use	VBN
cord-321868-xk4yuibj	208	26	to	to	TO
cord-321868-xk4yuibj	208	27	decode	decode	VB
cord-321868-xk4yuibj	208	28	the	the	DT
cord-321868-xk4yuibj	208	29	CUU	CUU	NNP
cord-321868-xk4yuibj	208	30	codon	codon	NN
cord-321868-xk4yuibj	208	31	.	.	.
cord-321868-xk4yuibj	209	1	If	if	IN
cord-321868-xk4yuibj	209	2	another	another	DT
cord-321868-xk4yuibj	209	3	isoaccepting	isoaccepting	NN
cord-321868-xk4yuibj	209	4	species	specie	NNS
cord-321868-xk4yuibj	209	5	,	,	,
cord-321868-xk4yuibj	209	6	incapable	incapable	JJ
cord-321868-xk4yuibj	209	7	of	of	IN
cord-321868-xk4yuibj	209	8	frame	frame	NN
cord-321868-xk4yuibj	209	9	slippage	slippage	NN
cord-321868-xk4yuibj	209	10	,	,	,
cord-321868-xk4yuibj	209	11	were	be	VBD
cord-321868-xk4yuibj	209	12	to	to	TO
cord-321868-xk4yuibj	209	13	compete	compete	VB
cord-321868-xk4yuibj	209	14	with	with	IN
cord-321868-xk4yuibj	209	15	tRNA$	trna$	NN
cord-321868-xk4yuibj	209	16	for	for	IN
cord-321868-xk4yuibj	209	17	binding	bind	VBG
cord-321868-xk4yuibj	209	18	to	to	IN
cord-321868-xk4yuibj	209	19	the	the	DT
cord-321868-xk4yuibj	209	20	CUU	CUU	NNP
cord-321868-xk4yuibj	209	21	codon	codon	NN
cord-321868-xk4yuibj	209	22	,	,	,
cord-321868-xk4yuibj	209	23	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	209	24	would	would	MD
cord-321868-xk4yuibj	209	25	be	be	VB
cord-321868-xk4yuibj	209	26	reduced	reduce	VBN
cord-321868-xk4yuibj	209	27	.	.	.
cord-321868-xk4yuibj	210	1	have	have	VBP
cord-321868-xk4yuibj	210	2	proposed	propose	VBN
cord-321868-xk4yuibj	210	3	a	a	DT
cord-321868-xk4yuibj	210	4	different	different	JJ
cord-321868-xk4yuibj	210	5	model	model	NN
cord-321868-xk4yuibj	210	6	for	for	IN
cord-321868-xk4yuibj	210	7	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	210	8	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	210	9	at	at	IN
cord-321868-xk4yuibj	210	10	"	"	``
cord-321868-xk4yuibj	210	11	hungry	hungry	JJ
cord-321868-xk4yuibj	210	12	"	"	''
cord-321868-xk4yuibj	210	13	codons	codon	NNS
cord-321868-xk4yuibj	210	14	in	in	IN
cord-321868-xk4yuibj	210	15	E.	E.	NNP
cord-321868-xk4yuibj	210	16	coli	coli	NNS
cord-321868-xk4yuibj	210	17	.	.	.
cord-321868-xk4yuibj	211	1	The	the	DT
cord-321868-xk4yuibj	211	2	model	model	NN
cord-321868-xk4yuibj	211	3	predicts	predict	VBZ
cord-321868-xk4yuibj	211	4	that	that	IN
cord-321868-xk4yuibj	211	5	in	in	IN
cord-321868-xk4yuibj	211	6	a	a	DT
cord-321868-xk4yuibj	211	7	situation	situation	NN
cord-321868-xk4yuibj	211	8	where	where	WRB
cord-321868-xk4yuibj	211	9	the	the	DT
cord-321868-xk4yuibj	211	10	A	A	NNP
cord-321868-xk4yuibj	211	11	site	site	NN
cord-321868-xk4yuibj	211	12	is	be	VBZ
cord-321868-xk4yuibj	211	13	unoccupied	unoccupied	JJ
cord-321868-xk4yuibj	211	14	during	during	IN
cord-321868-xk4yuibj	211	15	a	a	DT
cord-321868-xk4yuibj	211	16	very	very	RB
cord-321868-xk4yuibj	211	17	long	long	JJ
cord-321868-xk4yuibj	211	18	pause	pause	NN
cord-321868-xk4yuibj	211	19	,	,	,
cord-321868-xk4yuibj	211	20	a	a	DT
cord-321868-xk4yuibj	211	21	tRNA	trna	NN
cord-321868-xk4yuibj	211	22	can	can	MD
cord-321868-xk4yuibj	211	23	bind	bind	VB
cord-321868-xk4yuibj	211	24	out	out	IN
cord-321868-xk4yuibj	211	25	of	of	IN
cord-321868-xk4yuibj	211	26	frame	frame	NN
cord-321868-xk4yuibj	211	27	,	,	,
cord-321868-xk4yuibj	211	28	either	either	CC
cord-321868-xk4yuibj	211	29	+	+	CC
cord-321868-xk4yuibj	211	30	l	l	NN
cord-321868-xk4yuibj	211	31	or	or	CC
cord-321868-xk4yuibj	211	32	-1	-1	NNP
cord-321868-xk4yuibj	211	33	,	,	,
cord-321868-xk4yuibj	211	34	in	in	IN
cord-321868-xk4yuibj	211	35	violation	violation	NN
cord-321868-xk4yuibj	211	36	of	of	IN
cord-321868-xk4yuibj	211	37	the	the	DT
cord-321868-xk4yuibj	211	38	normal	normal	JJ
cord-321868-xk4yuibj	211	39	frame	frame	NN
cord-321868-xk4yuibj	211	40	maintenance	maintenance	NN
cord-321868-xk4yuibj	211	41	mechanism	mechanism	NN
cord-321868-xk4yuibj	211	42	.	.	.
cord-321868-xk4yuibj	212	1	If	if	IN
cord-321868-xk4yuibj	212	2	this	this	DT
cord-321868-xk4yuibj	212	3	model	model	NN
cord-321868-xk4yuibj	212	4	were	be	VBD
cord-321868-xk4yuibj	212	5	to	to	TO
cord-321868-xk4yuibj	212	6	operate	operate	VB
cord-321868-xk4yuibj	212	7	in	in	IN
cord-321868-xk4yuibj	212	8	the	the	DT
cord-321868-xk4yuibj	212	9	Ty	Ty	NNP
cord-321868-xk4yuibj	212	10	case	case	NN
cord-321868-xk4yuibj	212	11	,	,	,
cord-321868-xk4yuibj	212	12	one	one	PRP
cord-321868-xk4yuibj	212	13	would	would	MD
cord-321868-xk4yuibj	212	14	see	see	VB
cord-321868-xk4yuibj	212	15	the	the	DT
cord-321868-xk4yuibj	212	16	same	same	JJ
cord-321868-xk4yuibj	212	17	peptide	peptide	JJ
cord-321868-xk4yuibj	212	18	sequence	sequence	NN
cord-321868-xk4yuibj	212	19	at	at	IN
cord-321868-xk4yuibj	212	20	the	the	DT
cord-321868-xk4yuibj	212	21	frameshift	frameshift	NN
cord-321868-xk4yuibj	212	22	site	site	NN
cord-321868-xk4yuibj	212	23	that	that	WDT
cord-321868-xk4yuibj	212	24	we	-PRON-	PRP
cord-321868-xk4yuibj	212	25	determined	determine	VBD
cord-321868-xk4yuibj	212	26	,	,	,
cord-321868-xk4yuibj	212	27	Leu	Leu	NNP
cord-321868-xk4yuibj	212	28	-	-	HYPH
cord-321868-xk4yuibj	212	29	Gly	Gly	NNP
cord-321868-xk4yuibj	212	30	-	-	HYPH
cord-321868-xk4yuibj	212	31	His	His	NNP
cord-321868-xk4yuibj	212	32	.	.	.
cord-321868-xk4yuibj	213	1	However	however	RB
cord-321868-xk4yuibj	213	2	,	,	,
cord-321868-xk4yuibj	213	3	the	the	DT
cord-321868-xk4yuibj	213	4	ability	ability	NN
cord-321868-xk4yuibj	213	5	of	of	IN
cord-321868-xk4yuibj	213	6	the	the	DT
cord-321868-xk4yuibj	213	7	peptidyl	peptidyl	NNP
cord-321868-xk4yuibj	213	8	-	-	:
cord-321868-xk4yuibj	213	9	tRNALeU	tRNALeU	NNP
cord-321868-xk4yuibj	213	10	to	to	TO
cord-321868-xk4yuibj	213	11	slip	slip	VB
cord-321868-xk4yuibj	213	12	would	would	MD
cord-321868-xk4yuibj	213	13	be	be	VB
cord-321868-xk4yuibj	213	14	irrelevant	irrelevant	JJ
cord-321868-xk4yuibj	213	15	.	.	.
cord-321868-xk4yuibj	214	1	To	to	TO
cord-321868-xk4yuibj	214	2	test	test	VB
cord-321868-xk4yuibj	214	3	the	the	DT
cord-321868-xk4yuibj	214	4	model	model	NN
cord-321868-xk4yuibj	214	5	of	of	IN
cord-321868-xk4yuibj	214	6	peptidyl	peptidyl	NNP
cord-321868-xk4yuibj	214	7	-	-	HYPH
cord-321868-xk4yuibj	214	8	tRNALeU	tRNALeU	JJR
cord-321868-xk4yuibj	214	9	slippage	slippage	NN
cord-321868-xk4yuibj	214	10	,	,	,
cord-321868-xk4yuibj	214	11	we	-PRON-	PRP
cord-321868-xk4yuibj	214	12	constructed	construct	VBD
cord-321868-xk4yuibj	214	13	three	three	CD
cord-321868-xk4yuibj	214	14	novel	novel	JJ
cord-321868-xk4yuibj	214	15	tRNAs	trna	NNS
cord-321868-xk4yuibj	214	16	bearing	bear	VBG
cord-321868-xk4yuibj	214	17	modified	modify	VBN
cord-321868-xk4yuibj	214	18	anticodons	anticodon	NNS
cord-321868-xk4yuibj	214	19	by	by	IN
cord-321868-xk4yuibj	214	20	modifying	modify	VBG
cord-321868-xk4yuibj	214	21	the	the	DT
cord-321868-xk4yuibj	214	22	anticodon	anticodon	NN
cord-321868-xk4yuibj	214	23	of	of	IN
cord-321868-xk4yuibj	214	24	a	a	DT
cord-321868-xk4yuibj	214	25	gene	gene	NN
cord-321868-xk4yuibj	214	26	for	for	IN
cord-321868-xk4yuibj	214	27	the	the	DT
cord-321868-xk4yuibj	214	28	most	most	RBS
cord-321868-xk4yuibj	214	29	abundant	abundant	JJ
cord-321868-xk4yuibj	214	30	isoacceptor	isoacceptor	NN
cord-321868-xk4yuibj	214	31	,	,	,
cord-321868-xk4yuibj	214	32	tRNA	tRNA	NNP
cord-321868-xk4yuibj	214	33	&	&	CC
cord-321868-xk4yuibj	214	34	,	,	,
cord-321868-xk4yuibj	214	35	also	also	RB
cord-321868-xk4yuibj	214	36	known	know	VBN
cord-321868-xk4yuibj	214	37	as	as	IN
cord-321868-xk4yuibj	214	38	tRNAp	trnap	ADD
cord-321868-xk4yuibj	214	39	(	(	-LRB-
cord-321868-xk4yuibj	214	40	see	see	VB
cord-321868-xk4yuibj	214	41	Experimental	Experimental	NNP
cord-321868-xk4yuibj	214	42	Procedures	procedure	NNS
cord-321868-xk4yuibj	214	43	)	)	-RRB-
cord-321868-xk4yuibj	214	44	.	.	.
cord-321868-xk4yuibj	215	1	The	the	DT
cord-321868-xk4yuibj	215	2	first	first	JJ
cord-321868-xk4yuibj	215	3	,	,	,
cord-321868-xk4yuibj	215	4	with	with	IN
cord-321868-xk4yuibj	215	5	the	the	DT
cord-321868-xk4yuibj	215	6	anticodon	anticodon	NN
cord-321868-xk4yuibj	215	7	AAG	AAG	NNP
cord-321868-xk4yuibj	215	8	(	(	-LRB-
cord-321868-xk4yuibj	215	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	215	10	&	&	CC
cord-321868-xk4yuibj	215	11	)	)	-RRB-
cord-321868-xk4yuibj	215	12	,	,	,
cord-321868-xk4yuibj	215	13	can	can	MD
cord-321868-xk4yuibj	215	14	decode	decode	VB
cord-321868-xk4yuibj	215	15	CUU	CUU	NNP
cord-321868-xk4yuibj	215	16	but	but	CC
cord-321868-xk4yuibj	215	17	is	be	VBZ
cord-321868-xk4yuibj	215	18	incapable	incapable	JJ
cord-321868-xk4yuibj	215	19	of	of	IN
cord-321868-xk4yuibj	215	20	recognizing	recognize	VBG
cord-321868-xk4yuibj	215	21	the	the	DT
cord-321868-xk4yuibj	215	22	overlapping	overlap	VBG
cord-321868-xk4yuibj	215	23	UUA	UUA	NNP
cord-321868-xk4yuibj	215	24	codon	codon	NN
cord-321868-xk4yuibj	215	25	.	.	.
cord-321868-xk4yuibj	216	1	The	the	DT
cord-321868-xk4yuibj	216	2	second	second	JJ
cord-321868-xk4yuibj	216	3	has	have	VBZ
cord-321868-xk4yuibj	216	4	the	the	DT
cord-321868-xk4yuibj	216	5	anticodon	anticodon	NNP
cord-321868-xk4yuibj	216	6	UAG	UAG	NNP
cord-321868-xk4yuibj	216	7	(	(	-LRB-
cord-321868-xk4yuibj	216	8	termed	term	VBN
cord-321868-xk4yuibj	216	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	216	10	&	&	CC
cord-321868-xk4yuibj	216	11	,	,	,
cord-321868-xk4yuibj	216	12	to	to	TO
cord-321868-xk4yuibj	216	13	distinguish	distinguish	VB
cord-321868-xk4yuibj	216	14	it	-PRON-	PRP
cord-321868-xk4yuibj	216	15	from	from	IN
cord-321868-xk4yuibj	216	16	the	the	DT
cord-321868-xk4yuibj	216	17	wild	wild	JJ
cord-321868-xk4yuibj	216	18	-	-	HYPH
cord-321868-xk4yuibj	216	19	type	type	NN
cord-321868-xk4yuibj	216	20	tRNA$	trna$	NN
cord-321868-xk4yuibj	216	21	)	)	-RRB-
cord-321868-xk4yuibj	216	22	,	,	,
cord-321868-xk4yuibj	216	23	and	and	CC
cord-321868-xk4yuibj	216	24	the	the	DT
cord-321868-xk4yuibj	216	25	third	third	JJ
cord-321868-xk4yuibj	216	26	is	be	VBZ
cord-321868-xk4yuibj	216	27	an	an	DT
cord-321868-xk4yuibj	216	28	ochre	ochre	JJ
cord-321868-xk4yuibj	216	29	suppressor	suppressor	NN
cord-321868-xk4yuibj	216	30	with	with	IN
cord-321868-xk4yuibj	216	31	the	the	DT
cord-321868-xk4yuibj	216	32	anticodon	anticodon	NN
cord-321868-xk4yuibj	216	33	UUA	UUA	NNP
cord-321868-xk4yuibj	216	34	(	(	-LRB-
cord-321868-xk4yuibj	216	35	tRNA	tRNA	NNP
cord-321868-xk4yuibj	216	36	:	:	:
cord-321868-xk4yuibj	216	37	e	e	LS
cord-321868-xk4yuibj	216	38	,	,	,
cord-321868-xk4yuibj	216	39	"	"	''
cord-321868-xk4yuibj	216	40	,	,	,
cord-321868-xk4yuibj	216	41	)	)	-RRB-
cord-321868-xk4yuibj	216	42	.	.	.
cord-321868-xk4yuibj	217	1	The	the	DT
cord-321868-xk4yuibj	217	2	latter	latter	JJ
cord-321868-xk4yuibj	217	3	two	two	CD
cord-321868-xk4yuibj	217	4	serve	serve	VBP
cord-321868-xk4yuibj	217	5	as	as	IN
cord-321868-xk4yuibj	217	6	controls	control	NNS
cord-321868-xk4yuibj	217	7	since	since	IN
cord-321868-xk4yuibj	217	8	neither	neither	DT
cord-321868-xk4yuibj	217	9	is	be	VBZ
cord-321868-xk4yuibj	217	10	expected	expect	VBN
cord-321868-xk4yuibj	217	11	to	to	TO
cord-321868-xk4yuibj	217	12	interfere	interfere	VB
cord-321868-xk4yuibj	217	13	with	with	IN
cord-321868-xk4yuibj	217	14	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	217	15	.	.	.
cord-321868-xk4yuibj	218	1	Changing	change	VBG
cord-321868-xk4yuibj	218	2	the	the	DT
cord-321868-xk4yuibj	218	3	anticodon	anticodon	NN
cord-321868-xk4yuibj	218	4	should	should	MD
cord-321868-xk4yuibj	218	5	have	have	VB
cord-321868-xk4yuibj	218	6	no	no	DT
cord-321868-xk4yuibj	218	7	effect	effect	NN
cord-321868-xk4yuibj	218	8	on	on	IN
cord-321868-xk4yuibj	218	9	charging	charging	NN
cord-321868-xk4yuibj	218	10	of	of	IN
cord-321868-xk4yuibj	218	11	the	the	DT
cord-321868-xk4yuibj	218	12	tRNA	trna	NN
cord-321868-xk4yuibj	218	13	by	by	IN
cord-321868-xk4yuibj	218	14	leucine	leucine	NN
cord-321868-xk4yuibj	218	15	aminoacyl	aminoacyl	NNP
cord-321868-xk4yuibj	218	16	-	-	HYPH
cord-321868-xk4yuibj	218	17	tRNA	trna	NN
cord-321868-xk4yuibj	218	18	synthetase	synthetase	NN
cord-321868-xk4yuibj	218	19	for	for	IN
cord-321868-xk4yuibj	218	20	two	two	CD
cord-321868-xk4yuibj	218	21	reasons	reason	NNS
cord-321868-xk4yuibj	218	22	.	.	.
cord-321868-xk4yuibj	219	1	First	first	RB
cord-321868-xk4yuibj	219	2	,	,	,
cord-321868-xk4yuibj	219	3	leucine	leucine	NN
cord-321868-xk4yuibj	219	4	is	be	VBZ
cord-321868-xk4yuibj	219	5	encoded	encode	VBN
cord-321868-xk4yuibj	219	6	by	by	IN
cord-321868-xk4yuibj	219	7	six	six	CD
cord-321868-xk4yuibj	219	8	codons	codon	NNS
cord-321868-xk4yuibj	219	9	,	,	,
cord-321868-xk4yuibj	219	10	the	the	DT
cord-321868-xk4yuibj	219	11	only	only	JJ
cord-321868-xk4yuibj	219	12	common	common	JJ
cord-321868-xk4yuibj	219	13	feature	feature	NN
cord-321868-xk4yuibj	219	14	of	of	IN
cord-321868-xk4yuibj	219	15	which	which	WDT
cord-321868-xk4yuibj	219	16	is	be	VBZ
cord-321868-xk4yuibj	219	17	the	the	DT
cord-321868-xk4yuibj	219	18	central	central	JJ
cord-321868-xk4yuibj	219	19	U	U	NNP
cord-321868-xk4yuibj	219	20	residue	residue	NN
cord-321868-xk4yuibj	219	21	.	.	.
cord-321868-xk4yuibj	220	1	Second	second	JJ
cord-321868-xk4yuibj	220	2	,	,	,
cord-321868-xk4yuibj	220	3	functional	functional	JJ
cord-321868-xk4yuibj	220	4	amber	amber	NN
cord-321868-xk4yuibj	220	5	and	and	CC
cord-321868-xk4yuibj	220	6	ochre	ochre	NN
cord-321868-xk4yuibj	220	7	suppressor	suppressor	NN
cord-321868-xk4yuibj	220	8	forms	form	NNS
cord-321868-xk4yuibj	220	9	of	of	IN
cord-321868-xk4yuibj	220	10	tRNALeU	tRNALeU	NNS
cord-321868-xk4yuibj	220	11	exist	exist	VBP
cord-321868-xk4yuibj	220	12	(	(	-LRB-
cord-321868-xk4yuibj	220	13	Sherman	Sherman	NNP
cord-321868-xk4yuibj	220	14	,	,	,
cord-321868-xk4yuibj	220	15	1982	1982	CD
cord-321868-xk4yuibj	220	16	)	)	-RRB-
cord-321868-xk4yuibj	220	17	.	.	.
cord-321868-xk4yuibj	221	1	The	the	DT
cord-321868-xk4yuibj	221	2	tRNA	trna	NN
cord-321868-xk4yuibj	221	3	genes	gene	NNS
cord-321868-xk4yuibj	221	4	were	be	VBD
cord-321868-xk4yuibj	221	5	cloned	clone	VBN
cord-321868-xk4yuibj	221	6	into	into	IN
cord-321868-xk4yuibj	221	7	the	the	DT
cord-321868-xk4yuibj	221	8	plasmid	plasmid	NN
cord-321868-xk4yuibj	221	9	pMB38	pMB38	NNP
cord-321868-xk4yuibj	221	10	-	-	HYPH
cord-321868-xk4yuibj	221	11	9merWT	9merwt	CD
cord-321868-xk4yuibj	221	12	(	(	-LRB-
cord-321868-xk4yuibj	221	13	see	see	VB
cord-321868-xk4yuibj	221	14	previous	previous	JJ
cord-321868-xk4yuibj	221	15	section	section	NN
cord-321868-xk4yuibj	221	16	)	)	-RRB-
cord-321868-xk4yuibj	221	17	and	and	CC
cord-321868-xk4yuibj	221	18	introduced	introduce	VBN
cord-321868-xk4yuibj	221	19	into	into	IN
cord-321868-xk4yuibj	221	20	yeast	yeast	NN
cord-321868-xk4yuibj	221	21	.	.	.
cord-321868-xk4yuibj	222	1	The	the	DT
cord-321868-xk4yuibj	222	2	rate	rate	NN
cord-321868-xk4yuibj	222	3	of	of	IN
cord-321868-xk4yuibj	222	4	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	222	5	was	be	VBD
cord-321868-xk4yuibj	222	6	drastically	drastically	RB
cord-321868-xk4yuibj	222	7	lower	low	JJR
cord-321868-xk4yuibj	222	8	in	in	IN
cord-321868-xk4yuibj	222	9	the	the	DT
cord-321868-xk4yuibj	222	10	presence	presence	NN
cord-321868-xk4yuibj	222	11	of	of	IN
cord-321868-xk4yuibj	222	12	tRNA!$	trna!$	NN
cord-321868-xk4yuibj	223	1	but	but	CC
cord-321868-xk4yuibj	223	2	not	not	RB
cord-321868-xk4yuibj	223	3	with	with	IN
cord-321868-xk4yuibj	223	4	tRNA	tRNA	NNP
cord-321868-xk4yuibj	223	5	&	&	CC
cord-321868-xk4yuibj	223	6	&	&	CC
cord-321868-xk4yuibj	223	7	,	,	,
cord-321868-xk4yuibj	223	8	while	while	IN
cord-321868-xk4yuibj	223	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	223	10	&	&	CC
cord-321868-xk4yuibj	223	11	had	have	VBD
cord-321868-xk4yuibj	223	12	no	no	DT
cord-321868-xk4yuibj	223	13	effect	effect	NN
cord-321868-xk4yuibj	223	14	(	(	-LRB-
cord-321868-xk4yuibj	224	1	Table	table	NN
cord-321868-xk4yuibj	224	2	3	3	CD
cord-321868-xk4yuibj	224	3	)	)	-RRB-
cord-321868-xk4yuibj	224	4	.	.	.
cord-321868-xk4yuibj	225	1	The	the	DT
cord-321868-xk4yuibj	225	2	43-fold	43-fold	CD
cord-321868-xk4yuibj	225	3	decrease	decrease	NN
cord-321868-xk4yuibj	225	4	in	in	IN
cord-321868-xk4yuibj	225	5	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	226	1	In	in	IN
cord-321868-xk4yuibj	226	2	the	the	DT
cord-321868-xk4yuibj	226	3	presence	presence	NN
cord-321868-xk4yuibj	226	4	of	of	IN
cord-321868-xk4yuibj	226	5	tRNAfA	tRNAfA	NNP
cord-321868-xk4yuibj	226	6	;	;	,
cord-321868-xk4yuibj	226	7	suggests	suggest	VBZ
cord-321868-xk4yuibj	226	8	that	that	IN
cord-321868-xk4yuibj	226	9	it	-PRON-	PRP
cord-321868-xk4yuibj	226	10	has	have	VBZ
cord-321868-xk4yuibj	226	11	competed	compete	VBN
cord-321868-xk4yuibj	226	12	away	away	RB
cord-321868-xk4yuibj	226	13	98	98	CD
cord-321868-xk4yuibj	226	14	%	%	NN
cord-321868-xk4yuibj	226	15	of	of	IN
cord-321868-xk4yuibj	226	16	the	the	DT
cord-321868-xk4yuibj	226	17	binding	binding	NN
cord-321868-xk4yuibj	226	18	of	of	IN
cord-321868-xk4yuibj	226	19	a	a	DT
cord-321868-xk4yuibj	226	20	tRNA	trna	NN
cord-321868-xk4yuibj	226	21	responsible	responsible	JJ
cord-321868-xk4yuibj	226	22	for	for	IN
cord-321868-xk4yuibj	226	23	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	226	24	.	.	.
cord-321868-xk4yuibj	227	1	Although	although	IN
cord-321868-xk4yuibj	227	2	the	the	DT
cord-321868-xk4yuibj	227	3	data	datum	NNS
cord-321868-xk4yuibj	227	4	do	do	VBP
cord-321868-xk4yuibj	227	5	not	not	RB
cord-321868-xk4yuibj	227	6	directly	directly	RB
cord-321868-xk4yuibj	227	7	identify	identify	VB
cord-321868-xk4yuibj	227	8	tRNApiG	tRNApiG	NNP
cord-321868-xk4yuibj	227	9	as	as	IN
cord-321868-xk4yuibj	227	10	the	the	DT
cord-321868-xk4yuibj	227	11	"	"	``
cord-321868-xk4yuibj	227	12	shifty	shifty	JJ
cord-321868-xk4yuibj	227	13	"	"	''
cord-321868-xk4yuibj	227	14	tRNA	trna	NN
cord-321868-xk4yuibj	227	15	,	,	,
cord-321868-xk4yuibj	227	16	they	-PRON-	PRP
cord-321868-xk4yuibj	227	17	do	do	VBP
cord-321868-xk4yuibj	227	18	demonstrate	demonstrate	VB
cord-321868-xk4yuibj	227	19	that	that	IN
cord-321868-xk4yuibj	227	20	the	the	DT
cord-321868-xk4yuibj	227	21	ability	ability	NN
cord-321868-xk4yuibj	227	22	of	of	IN
cord-321868-xk4yuibj	227	23	the	the	DT
cord-321868-xk4yuibj	227	24	tRNA	trna	NN
cord-321868-xk4yuibj	227	25	decoding	decode	VBG
cord-321868-xk4yuibj	227	26	the	the	DT
cord-321868-xk4yuibj	227	27	CUU	CUU	NNP
cord-321868-xk4yuibj	227	28	codon	codon	NN
cord-321868-xk4yuibj	227	29	to	to	TO
cord-321868-xk4yuibj	227	30	slip	slip	VB
cord-321868-xk4yuibj	227	31	to	to	IN
cord-321868-xk4yuibj	227	32	UUA	UUA	NNP
cord-321868-xk4yuibj	227	33	is	be	VBZ
cord-321868-xk4yuibj	227	34	essential	essential	JJ
cord-321868-xk4yuibj	227	35	for	for	IN
cord-321868-xk4yuibj	227	36	Ty	Ty	NNP
cord-321868-xk4yuibj	227	37	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	227	38	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	227	39	.	.	.
cord-321868-xk4yuibj	228	1	Other	other	JJ
cord-321868-xk4yuibj	228	2	Codons	Codons	NNPS
cord-321868-xk4yuibj	228	3	Decoded	decode	VBN
cord-321868-xk4yuibj	228	4	by	by	IN
cord-321868-xk4yuibj	228	5	Rare	rare	JJ
cord-321868-xk4yuibj	228	6	tRNAs	tRNAs	NNPS
cord-321868-xk4yuibj	228	7	Can	can	MD
cord-321868-xk4yuibj	228	8	not	not	RB
cord-321868-xk4yuibj	228	9	Substitute	substitute	VB
cord-321868-xk4yuibj	228	10	for	for	IN
cord-321868-xk4yuibj	228	11	AGG	agg	NN
cord-321868-xk4yuibj	229	1	If	if	IN
cord-321868-xk4yuibj	229	2	the	the	DT
cord-321868-xk4yuibj	229	3	AGG	agg	NN
cord-321868-xk4yuibj	229	4	codon	codon	NN
cord-321868-xk4yuibj	229	5	of	of	IN
cord-321868-xk4yuibj	229	6	the	the	DT
cord-321868-xk4yuibj	229	7	frameshift	frameshift	NN
cord-321868-xk4yuibj	229	8	site	site	NN
cord-321868-xk4yuibj	229	9	induces	induce	VBZ
cord-321868-xk4yuibj	229	10	a	a	DT
cord-321868-xk4yuibj	229	11	translational	translational	JJ
cord-321868-xk4yuibj	229	12	pause	pause	NN
cord-321868-xk4yuibj	229	13	as	as	IN
cord-321868-xk4yuibj	229	14	a	a	DT
cord-321868-xk4yuibj	229	15	result	result	NN
cord-321868-xk4yuibj	229	16	of	of	IN
cord-321868-xk4yuibj	229	17	the	the	DT
cord-321868-xk4yuibj	229	18	low	low	JJ
cord-321868-xk4yuibj	229	19	availability	availability	NN
cord-321868-xk4yuibj	229	20	of	of	IN
cord-321868-xk4yuibj	229	21	its	-PRON-	PRP$
cord-321868-xk4yuibj	229	22	cognate	cognate	NN
cord-321868-xk4yuibj	229	23	tRNA	tRNA	NNP
cord-321868-xk4yuibj	229	24	,	,	,
cord-321868-xk4yuibj	229	25	is	be	VBZ
cord-321868-xk4yuibj	229	26	it	-PRON-	PRP
cord-321868-xk4yuibj	229	27	possible	possible	JJ
cord-321868-xk4yuibj	229	28	to	to	TO
cord-321868-xk4yuibj	229	29	induce	induce	VB
cord-321868-xk4yuibj	229	30	a	a	DT
cord-321868-xk4yuibj	229	31	translational	translational	JJ
cord-321868-xk4yuibj	229	32	pause	pause	NN
cord-321868-xk4yuibj	229	33	by	by	IN
cord-321868-xk4yuibj	229	34	substituting	substitute	VBG
cord-321868-xk4yuibj	229	35	a	a	DT
cord-321868-xk4yuibj	229	36	codon	codon	NN
cord-321868-xk4yuibj	229	37	recognized	recognize	VBN
cord-321868-xk4yuibj	229	38	by	by	IN
cord-321868-xk4yuibj	229	39	other	other	JJ
cord-321868-xk4yuibj	229	40	low	low	JJ
cord-321868-xk4yuibj	229	41	-	-	HYPH
cord-321868-xk4yuibj	229	42	abundance	abundance	NN
cord-321868-xk4yuibj	229	43	tRNAs	trna	NNS
cord-321868-xk4yuibj	229	44	?	?	.
cord-321868-xk4yuibj	230	1	We	-PRON-	PRP
cord-321868-xk4yuibj	230	2	replaced	replace	VBD
cord-321868-xk4yuibj	230	3	the	the	DT
cord-321868-xk4yuibj	230	4	AGG	agg	NN
cord-321868-xk4yuibj	230	5	codon	codon	NN
cord-321868-xk4yuibj	230	6	with	with	IN
cord-321868-xk4yuibj	230	7	two	two	CD
cord-321868-xk4yuibj	230	8	other	other	JJ
cord-321868-xk4yuibj	230	9	codons	codon	NNS
cord-321868-xk4yuibj	230	10	known	know	VBN
cord-321868-xk4yuibj	230	11	to	to	TO
cord-321868-xk4yuibj	230	12	be	be	VB
cord-321868-xk4yuibj	230	13	recognized	recognize	VBN
cord-321868-xk4yuibj	230	14	by	by	IN
cord-321868-xk4yuibj	230	15	tRNAs	trna	NNS
cord-321868-xk4yuibj	230	16	present	present	JJ
cord-321868-xk4yuibj	230	17	in	in	IN
cord-321868-xk4yuibj	230	18	low	low	JJ
cord-321868-xk4yuibj	230	19	concentration	concentration	NN
cord-321868-xk4yuibj	230	20	:	:	:
cord-321868-xk4yuibj	230	21	CGG	CGG	NNP
cord-321868-xk4yuibj	230	22	,	,	,
cord-321868-xk4yuibj	230	23	decoded	decode	VBN
cord-321868-xk4yuibj	230	24	by	by	IN
cord-321868-xk4yuibj	230	25	tRNA&o	tRNA&o	NNP
cord-321868-xk4yuibj	230	26	(	(	-LRB-
cord-321868-xk4yuibj	230	27	M.	M.	NNP
cord-321868-xk4yuibj	230	28	Culbertson	Culbertson	NNP
cord-321868-xk4yuibj	230	29	and	and	CC
cord-321868-xk4yuibj	230	30	I.	I.	NNP
cord-321868-xk4yuibj	230	31	Edelman	Edelman	NNP
cord-321868-xk4yuibj	230	32	,	,	,
cord-321868-xk4yuibj	230	33	personal	personal	JJ
cord-321868-xk4yuibj	230	34	communication	communication	NN
cord-321868-xk4yuibj	230	35	)	)	-RRB-
cord-321868-xk4yuibj	230	36	;	;	:
cord-321868-xk4yuibj	230	37	and	and	CC
cord-321868-xk4yuibj	230	38	UCG	UCG	NNP
cord-321868-xk4yuibj	230	39	,	,	,
cord-321868-xk4yuibj	230	40	decoded	decode	VBN
cord-321868-xk4yuibj	230	41	by	by	IN
cord-321868-xk4yuibj	230	42	tRNAp$	tRNAp$	NNP
cord-321868-xk4yuibj	230	43	,	,	,
cord-321868-xk4yuibj	230	44	(	(	-LRB-
cord-321868-xk4yuibj	230	45	Etcheverry	Etcheverry	NNP
cord-321868-xk4yuibj	230	46	et	et	FW
cord-321868-xk4yuibj	230	47	al	al	NNP
cord-321868-xk4yuibj	230	48	.	.	NNP
cord-321868-xk4yuibj	230	49	,	,	,
cord-321868-xk4yuibj	230	50	1982	1982	CD
cord-321868-xk4yuibj	230	51	;	;	.
cord-321868-xk4yuibj	231	1	Olson	Olson	NNP
cord-321868-xk4yuibj	231	2	et	et	NNP
cord-321868-xk4yuibj	231	3	al	al	NNP
cord-321868-xk4yuibj	231	4	.	.	NNP
cord-321868-xk4yuibj	231	5	,	,	,
cord-321868-xk4yuibj	231	6	1981	1981	CD
cord-321868-xk4yuibj	231	7	)	)	-RRB-
cord-321868-xk4yuibj	231	8	.	.	.
cord-321868-xk4yuibj	232	1	Like	like	IN
cord-321868-xk4yuibj	232	2	the	the	DT
cord-321868-xk4yuibj	232	3	tRNA&u	tRNA&u	NNP
cord-321868-xk4yuibj	232	4	gene	gene	NN
cord-321868-xk4yuibj	232	5	,	,	,
cord-321868-xk4yuibj	232	6	the	the	DT
cord-321868-xk4yuibj	232	7	tRNA&jo	tRNA&jo	NNP
cord-321868-xk4yuibj	232	8	and	and	CC
cord-321868-xk4yuibj	232	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	232	10	&	&	CC
cord-321868-xk4yuibj	232	11	*	*	NFP
cord-321868-xk4yuibj	232	12	genes	gene	NNS
cord-321868-xk4yuibj	232	13	are	be	VBP
cord-321868-xk4yuibj	232	14	present	present	JJ
cord-321868-xk4yuibj	232	15	in	in	IN
cord-321868-xk4yuibj	232	16	single	single	JJ
cord-321868-xk4yuibj	232	17	copies	copy	NNS
cord-321868-xk4yuibj	232	18	in	in	IN
cord-321868-xk4yuibj	232	19	the	the	DT
cord-321868-xk4yuibj	232	20	haploid	haploid	JJ
cord-321868-xk4yuibj	232	21	yeast	yeast	NN
cord-321868-xk4yuibj	232	22	genome	genome	NN
cord-321868-xk4yuibj	232	23	and	and	CC
cord-321868-xk4yuibj	232	24	are	be	VBP
cord-321868-xk4yuibj	232	25	lethal	lethal	JJ
cord-321868-xk4yuibj	232	26	to	to	IN
cord-321868-xk4yuibj	232	27	the	the	DT
cord-321868-xk4yuibj	232	28	cell	cell	NN
cord-321868-xk4yuibj	232	29	if	if	IN
cord-321868-xk4yuibj	232	30	deleted	delete	VBN
cord-321868-xk4yuibj	232	31	,	,	,
cord-321868-xk4yuibj	232	32	reflecting	reflect	VBG
cord-321868-xk4yuibj	232	33	the	the	DT
cord-321868-xk4yuibj	232	34	fact	fact	NN
cord-321868-xk4yuibj	232	35	that	that	IN
cord-321868-xk4yuibj	232	36	no	no	DT
cord-321868-xk4yuibj	232	37	other	other	JJ
cord-321868-xk4yuibj	232	38	tRNAs	trna	NNS
cord-321868-xk4yuibj	232	39	are	be	VBP
cord-321868-xk4yuibj	232	40	capable	capable	JJ
cord-321868-xk4yuibj	232	41	of	of	IN
cord-321868-xk4yuibj	232	42	decoding	decode	VBG
cord-321868-xk4yuibj	232	43	the	the	DT
cord-321868-xk4yuibj	232	44	CGG	CGG	NNP
cord-321868-xk4yuibj	232	45	or	or	CC
cord-321868-xk4yuibj	232	46	UCG	UCG	NNP
cord-321868-xk4yuibj	232	47	codons	codon	NNS
cord-321868-xk4yuibj	232	48	.	.	.
cord-321868-xk4yuibj	233	1	Oligonucleotides	oligonucleotides	NN
cord-321868-xk4yuibj	233	2	containing	contain	VBG
cord-321868-xk4yuibj	233	3	CGG	CGG	NNP
cord-321868-xk4yuibj	233	4	or	or	CC
cord-321868-xk4yuibj	233	5	UCG	UCG	NNP
cord-321868-xk4yuibj	233	6	at	at	IN
cord-321868-xk4yuibj	233	7	the	the	DT
cord-321868-xk4yuibj	233	8	AGG	agg	NN
cord-321868-xk4yuibj	233	9	position	position	NN
cord-321868-xk4yuibj	233	10	of	of	IN
cord-321868-xk4yuibj	233	11	the	the	DT
cord-321868-xk4yuibj	233	12	frameshift	frameshift	NN
cord-321868-xk4yuibj	233	13	site	site	NN
cord-321868-xk4yuibj	233	14	were	be	VBD
cord-321868-xk4yuibj	233	15	cloned	clone	VBN
cord-321868-xk4yuibj	233	16	into	into	IN
cord-321868-xk4yuibj	233	17	the	the	DT
cord-321868-xk4yuibj	233	18	frameshift	frameshift	NN
cord-321868-xk4yuibj	233	19	reporter	reporter	NN
cord-321868-xk4yuibj	233	20	plasmid	plasmid	NN
cord-321868-xk4yuibj	233	21	pMB38	pMB38	NNP
cord-321868-xk4yuibj	233	22	as	as	IN
cord-321868-xk4yuibj	233	23	described	describe	VBN
cord-321868-xk4yuibj	233	24	in	in	IN
cord-321868-xk4yuibj	233	25	Experimental	Experimental	NNP
cord-321868-xk4yuibj	233	26	Procedures	procedure	NNS
cord-321868-xk4yuibj	233	27	.	.	.
cord-321868-xk4yuibj	234	1	After	after	IN
cord-321868-xk4yuibj	234	2	introduction	introduction	NN
cord-321868-xk4yuibj	234	3	into	into	IN
cord-321868-xk4yuibj	234	4	yeast	yeast	NN
cord-321868-xk4yuibj	234	5	,	,	,
cord-321868-xk4yuibj	234	6	the	the	DT
cord-321868-xk4yuibj	234	7	constructs	construct	NNS
cord-321868-xk4yuibj	234	8	were	be	VBD
cord-321868-xk4yuibj	234	9	analyzed	analyze	VBN
cord-321868-xk4yuibj	234	10	for	for	IN
cord-321868-xk4yuibj	234	11	8-galactosidase	8-galactosidase	CD
cord-321868-xk4yuibj	234	12	production	production	NN
cord-321868-xk4yuibj	234	13	.	.	.
cord-321868-xk4yuibj	235	1	Both	both	DT
cord-321868-xk4yuibj	235	2	produced	produce	VBD
cord-321868-xk4yuibj	235	3	very	very	RB
cord-321868-xk4yuibj	235	4	low	low	JJ
cord-321868-xk4yuibj	235	5	levels	level	NNS
cord-321868-xk4yuibj	235	6	of	of	IN
cord-321868-xk4yuibj	235	7	enzyme	enzyme	NN
cord-321868-xk4yuibj	235	8	,	,	,
cord-321868-xk4yuibj	235	9	corresponding	correspond	VBG
cord-321868-xk4yuibj	235	10	to	to	IN
cord-321868-xk4yuibj	235	11	1.8	1.8	CD
cord-321868-xk4yuibj	235	12	%	%	NN
cord-321868-xk4yuibj	235	13	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	235	14	for	for	IN
cord-321868-xk4yuibj	235	15	CGG	CGG	NNP
cord-321868-xk4yuibj	235	16	and	and	CC
cord-321868-xk4yuibj	235	17	0.3	0.3	CD
cord-321868-xk4yuibj	235	18	%	%	NN
cord-321868-xk4yuibj	235	19	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	235	20	for	for	IN
cord-321868-xk4yuibj	235	21	UCG	UCG	NNP
cord-321868-xk4yuibj	235	22	(	(	-LRB-
cord-321868-xk4yuibj	235	23	Table	Table	NNP
cord-321868-xk4yuibj	235	24	4	4	CD
cord-321868-xk4yuibj	235	25	)	)	-RRB-
cord-321868-xk4yuibj	235	26	.	.	.
cord-321868-xk4yuibj	236	1	The	the	DT
cord-321868-xk4yuibj	236	2	CGG	CGG	NNP
cord-321868-xk4yuibj	236	3	construct	construct	NN
cord-321868-xk4yuibj	236	4	does	do	VBZ
cord-321868-xk4yuibj	236	5	support	support	VB
cord-321868-xk4yuibj	236	6	a	a	DT
cord-321868-xk4yuibj	236	7	significant	significant	JJ
cord-321868-xk4yuibj	236	8	level	level	NN
cord-321868-xk4yuibj	236	9	of	of	IN
cord-321868-xk4yuibj	236	10	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	236	11	but	but	CC
cord-321868-xk4yuibj	236	12	still	still	RB
cord-321868-xk4yuibj	236	13	is	be	VBZ
cord-321868-xk4yuibj	236	14	about	about	RB
cord-321868-xk4yuibj	236	15	25fold	25fold	CD
cord-321868-xk4yuibj	236	16	below	below	IN
cord-321868-xk4yuibj	236	17	that	that	DT
cord-321868-xk4yuibj	236	18	of	of	IN
cord-321868-xk4yuibj	236	19	the	the	DT
cord-321868-xk4yuibj	236	20	wild	wild	JJ
cord-321868-xk4yuibj	236	21	-	-	HYPH
cord-321868-xk4yuibj	236	22	type	type	NN
cord-321868-xk4yuibj	236	23	construct	construct	NN
cord-321868-xk4yuibj	236	24	with	with	IN
cord-321868-xk4yuibj	236	25	identical	identical	JJ
cord-321868-xk4yuibj	236	26	flanking	flanking	JJ
cord-321868-xk4yuibj	236	27	sequences	sequence	NNS
cord-321868-xk4yuibj	236	28	.	.	.
cord-321868-xk4yuibj	237	1	A	a	DT
cord-321868-xk4yuibj	237	2	possible	possible	JJ
cord-321868-xk4yuibj	237	3	problem	problem	NN
cord-321868-xk4yuibj	237	4	with	with	IN
cord-321868-xk4yuibj	237	5	this	this	DT
cord-321868-xk4yuibj	237	6	experiment	experiment	NN
cord-321868-xk4yuibj	237	7	is	be	VBZ
cord-321868-xk4yuibj	237	8	the	the	DT
cord-321868-xk4yuibj	237	9	elimination	elimination	NN
cord-321868-xk4yuibj	237	10	of	of	IN
cord-321868-xk4yuibj	237	11	the	the	DT
cord-321868-xk4yuibj	237	12	UUA	UUA	NNP
cord-321868-xk4yuibj	237	13	leucine	leucine	NN
cord-321868-xk4yuibj	237	14	codon	codon	NN
cord-321868-xk4yuibj	237	15	in	in	IN
cord-321868-xk4yuibj	237	16	the	the	DT
cord-321868-xk4yuibj	237	17	+	+	CC
cord-321868-xk4yuibj	237	18	l	l	NN
cord-321868-xk4yuibj	237	19	reading	reading	NN
cord-321868-xk4yuibj	237	20	frame	frame	NN
cord-321868-xk4yuibj	237	21	.	.	.
cord-321868-xk4yuibj	238	1	Perhaps	perhaps	RB
cord-321868-xk4yuibj	238	2	tRNA$	trna$	NN
cord-321868-xk4yuibj	238	3	&	&	CC
cord-321868-xk4yuibj	238	4	can	can	MD
cord-321868-xk4yuibj	238	5	not	not	RB
cord-321868-xk4yuibj	238	6	slip	slip	VB
cord-321868-xk4yuibj	238	7	from	from	IN
cord-321868-xk4yuibj	238	8	CUU	CUU	NNP
cord-321868-xk4yuibj	238	9	to	to	IN
cord-321868-xk4yuibj	238	10	UUC	UUC	NNP
cord-321868-xk4yuibj	238	11	or	or	CC
cord-321868-xk4yuibj	238	12	UUU	UUU	NNP
cord-321868-xk4yuibj	238	13	,	,	,
cord-321868-xk4yuibj	238	14	both	both	DT
cord-321868-xk4yuibj	238	15	phenylalanine	phenylalanine	NN
cord-321868-xk4yuibj	238	16	codons	codon	NNS
cord-321868-xk4yuibj	238	17	recognized	recognize	VBN
cord-321868-xk4yuibj	238	18	by	by	IN
cord-321868-xk4yuibj	238	19	a	a	DT
cord-321868-xk4yuibj	238	20	single	single	JJ
cord-321868-xk4yuibj	238	21	isoacceptor	isoacceptor	NN
cord-321868-xk4yuibj	238	22	,	,	,
cord-321868-xk4yuibj	238	23	tRNg	tRNg	NNP
cord-321868-xk4yuibj	238	24	'	'	''
cord-321868-xk4yuibj	238	25	&	&	CC
cord-321868-xk4yuibj	238	26	,	,	,
cord-321868-xk4yuibj	238	27	also	also	RB
cord-321868-xk4yuibj	238	28	known	know	VBN
cord-321868-xk4yuibj	238	29	as	as	IN
cord-321868-xk4yuibj	238	30	tRNAPhe	tRNAPhe	NNP
cord-321868-xk4yuibj	239	1	(	(	-LRB-
cord-321868-xk4yuibj	239	2	RajBhandary	RajBhandary	NNP
cord-321868-xk4yuibj	239	3	et	et	FW
cord-321868-xk4yuibj	239	4	al	al	NNP
cord-321868-xk4yuibj	239	5	.	.	NNP
cord-321868-xk4yuibj	239	6	,	,	,
cord-321868-xk4yuibj	239	7	1987	1987	CD
cord-321868-xk4yuibj	239	8	;	;	:
cord-321868-xk4yuibj	239	9	Valenzuela	Valenzuela	NNP
cord-321868-xk4yuibj	239	10	et	et	NNP
cord-321868-xk4yuibj	239	11	al	al	NNP
cord-321868-xk4yuibj	239	12	.	.	NNP
cord-321868-xk4yuibj	239	13	,	,	,
cord-321868-xk4yuibj	239	14	1978	1978	CD
cord-321868-xk4yuibj	239	15	)	)	-RRB-
cord-321868-xk4yuibj	239	16	.	.	.
cord-321868-xk4yuibj	240	1	To	to	TO
cord-321868-xk4yuibj	240	2	control	control	VB
cord-321868-xk4yuibj	240	3	for	for	IN
cord-321868-xk4yuibj	240	4	this	this	DT
cord-321868-xk4yuibj	240	5	,	,	,
cord-321868-xk4yuibj	240	6	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	240	7	were	be	VBD
cord-321868-xk4yuibj	240	8	constructed	construct	VBN
cord-321868-xk4yuibj	240	9	containing	contain	VBG
cord-321868-xk4yuibj	240	10	the	the	DT
cord-321868-xk4yuibj	240	11	same	same	JJ
cord-321868-xk4yuibj	240	12	substitutions	substitution	NNS
cord-321868-xk4yuibj	240	13	for	for	IN
cord-321868-xk4yuibj	240	14	AGG	agg	NN
cord-321868-xk4yuibj	240	15	as	as	IN
cord-321868-xk4yuibj	240	16	above	above	RB
cord-321868-xk4yuibj	240	17	,	,	,
cord-321868-xk4yuibj	240	18	but	but	CC
cord-321868-xk4yuibj	240	19	with	with	IN
cord-321868-xk4yuibj	240	20	only	only	RB
cord-321868-xk4yuibj	240	21	the	the	DT
cord-321868-xk4yuibj	240	22	first	first	JJ
cord-321868-xk4yuibj	240	23	position	position	NN
cord-321868-xk4yuibj	240	24	C	c	NN
cord-321868-xk4yuibj	240	25	of	of	IN
cord-321868-xk4yuibj	240	26	the	the	DT
cord-321868-xk4yuibj	240	27	CUU	CUU	NNP
cord-321868-xk4yuibj	240	28	codon	codon	NN
cord-321868-xk4yuibj	240	29	changed	change	VBD
cord-321868-xk4yuibj	240	30	to	to	IN
cord-321868-xk4yuibj	241	1	U.	U.	NNP
cord-321868-xk4yuibj	241	2	We	-PRON-	PRP
cord-321868-xk4yuibj	241	3	reasoned	reason	VBD
cord-321868-xk4yuibj	241	4	that	that	IN
cord-321868-xk4yuibj	241	5	tRN@	tRN@	NNP
cord-321868-xk4yuibj	241	6	&	&	CC
cord-321868-xk4yuibj	241	7	should	should	MD
cord-321868-xk4yuibj	241	8	be	be	VB
cord-321868-xk4yuibj	241	9	able	able	JJ
cord-321868-xk4yuibj	241	10	to	to	TO
cord-321868-xk4yuibj	241	11	shift	shift	VB
cord-321868-xk4yuibj	241	12	from	from	IN
cord-321868-xk4yuibj	241	13	UUU	UUU	NNP
cord-321868-xk4yuibj	241	14	to	to	IN
cord-321868-xk4yuibj	241	15	UUU	UUU	NNP
cord-321868-xk4yuibj	241	16	or	or	CC
cord-321868-xk4yuibj	241	17	UUC	UUC	NNP
cord-321868-xk4yuibj	241	18	of	of	IN
cord-321868-xk4yuibj	241	19	the	the	DT
cord-321868-xk4yuibj	241	20	+	+	CC
cord-321868-xk4yuibj	241	21	l	l	NN
cord-321868-xk4yuibj	241	22	reading	reading	NN
cord-321868-xk4yuibj	241	23	frame	frame	NN
cord-321868-xk4yuibj	241	24	of	of	IN
cord-321868-xk4yuibj	241	25	each	each	DT
cord-321868-xk4yuibj	241	26	construct	construct	NN
cord-321868-xk4yuibj	241	27	(	(	-LRB-
cord-321868-xk4yuibj	241	28	Table	table	NN
cord-321868-xk4yuibj	241	29	4	4	CD
cord-321868-xk4yuibj	241	30	)	)	-RRB-
cord-321868-xk4yuibj	241	31	because	because	IN
cord-321868-xk4yuibj	241	32	the	the	DT
cord-321868-xk4yuibj	241	33	HIV-1	HIV-1	NNP
cord-321868-xk4yuibj	241	34	frameshift	frameshift	NN
cord-321868-xk4yuibj	241	35	event	event	NN
cord-321868-xk4yuibj	241	36	can	can	MD
cord-321868-xk4yuibj	241	37	occur	occur	VB
cord-321868-xk4yuibj	241	38	in	in	IN
cord-321868-xk4yuibj	241	39	the	the	DT
cord-321868-xk4yuibj	241	40	-1	-1	JJ
cord-321868-xk4yuibj	241	41	direction	direction	NN
cord-321868-xk4yuibj	241	42	on	on	IN
cord-321868-xk4yuibj	241	43	a	a	DT
cord-321868-xk4yuibj	241	44	string	string	NN
cord-321868-xk4yuibj	241	45	of	of	IN
cord-321868-xk4yuibj	241	46	8	8	CD
cord-321868-xk4yuibj	241	47	uracil	uracil	NN
cord-321868-xk4yuibj	241	48	residues	residue	NNS
cord-321868-xk4yuibj	241	49	in	in	IN
cord-321868-xk4yuibj	241	50	yeast	yeast	NN
cord-321868-xk4yuibj	242	1	(	(	-LRB-
cord-321868-xk4yuibj	242	2	Wilson	Wilson	NNP
cord-321868-xk4yuibj	242	3	et	et	NNP
cord-321868-xk4yuibj	242	4	al	al	NNP
cord-321868-xk4yuibj	242	5	.	.	NNP
cord-321868-xk4yuibj	242	6	,	,	,
cord-321868-xk4yuibj	242	7	1988	1988	CD
cord-321868-xk4yuibj	242	8	)	)	-RRB-
cord-321868-xk4yuibj	242	9	.	.	.
cord-321868-xk4yuibj	243	1	As	as	IN
cord-321868-xk4yuibj	243	2	can	can	MD
cord-321868-xk4yuibj	243	3	be	be	VB
cord-321868-xk4yuibj	243	4	seen	see	VBN
cord-321868-xk4yuibj	243	5	from	from	IN
cord-321868-xk4yuibj	243	6	the	the	DT
cord-321868-xk4yuibj	243	7	data	datum	NNS
cord-321868-xk4yuibj	243	8	,	,	,
cord-321868-xk4yuibj	243	9	this	this	DT
cord-321868-xk4yuibj	243	10	change	change	NN
cord-321868-xk4yuibj	243	11	did	do	VBD
cord-321868-xk4yuibj	243	12	not	not	RB
cord-321868-xk4yuibj	243	13	improve	improve	VB
cord-321868-xk4yuibj	243	14	the	the	DT
cord-321868-xk4yuibj	243	15	ability	ability	NN
cord-321868-xk4yuibj	243	16	of	of	IN
cord-321868-xk4yuibj	243	17	the	the	DT
cord-321868-xk4yuibj	243	18	sequences	sequence	NNS
cord-321868-xk4yuibj	243	19	to	to	TO
cord-321868-xk4yuibj	243	20	support	support	VB
cord-321868-xk4yuibj	243	21	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	243	22	(	(	-LRB-
cord-321868-xk4yuibj	243	23	Table	table	NN
cord-321868-xk4yuibj	243	24	4	4	CD
cord-321868-xk4yuibj	243	25	)	)	-RRB-
cord-321868-xk4yuibj	243	26	.	.	.
cord-321868-xk4yuibj	244	1	A	a	DT
cord-321868-xk4yuibj	244	2	more	more	RBR
cord-321868-xk4yuibj	244	3	controlled	control	VBN
cord-321868-xk4yuibj	244	4	experiment	experiment	NN
cord-321868-xk4yuibj	244	5	utilizes	utilize	VBZ
cord-321868-xk4yuibj	244	6	a	a	DT
cord-321868-xk4yuibj	244	7	well	well	RB
cord-321868-xk4yuibj	244	8	-	-	HYPH
cord-321868-xk4yuibj	244	9	characterized	characterize	VBN
cord-321868-xk4yuibj	244	10	set	set	NN
cord-321868-xk4yuibj	244	11	of	of	IN
cord-321868-xk4yuibj	244	12	tRNA	tRNA	NNP
cord-321868-xk4yuibj	244	13	&	&	CC
cord-321868-xk4yuibj	244	14	gene	gene	NNP
cord-321868-xk4yuibj	244	15	deletion	deletion	NN
cord-321868-xk4yuibj	244	16	constructs	construct	VBZ
cord-321868-xk4yuibj	244	17	.	.	.
cord-321868-xk4yuibj	245	1	The	the	DT
cord-321868-xk4yuibj	245	2	UAY	uay	JJ
cord-321868-xk4yuibj	245	3	codon	codon	NN
cord-321868-xk4yuibj	245	4	is	be	VBZ
cord-321868-xk4yuibj	245	5	decoded	decode	VBN
cord-321868-xk4yuibj	245	6	by	by	IN
cord-321868-xk4yuibj	245	7	an	an	DT
cord-321868-xk4yuibj	245	8	abundant	abundant	JJ
cord-321868-xk4yuibj	245	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	245	10	(	(	-LRB-
cord-321868-xk4yuibj	245	11	tRNA	tRNA	NNP
cord-321868-xk4yuibj	245	12	&	&	CC
cord-321868-xk4yuibj	245	13	;	;	:
cord-321868-xk4yuibj	245	14	also	also	RB
cord-321868-xk4yuibj	245	15	called	call	VBN
cord-321868-xk4yuibj	245	16	tRNATYr	trnatyr	CD
cord-321868-xk4yuibj	245	17	)	)	-RRB-
cord-321868-xk4yuibj	245	18	encoded	encode	VBN
cord-321868-xk4yuibj	245	19	by	by	IN
cord-321868-xk4yuibj	245	20	eight	eight	CD
cord-321868-xk4yuibj	245	21	unlinked	unlinked	JJ
cord-321868-xk4yuibj	245	22	genes	gene	NNS
cord-321868-xk4yuibj	245	23	in	in	IN
cord-321868-xk4yuibj	245	24	the	the	DT
cord-321868-xk4yuibj	245	25	haploid	haploid	JJ
cord-321868-xk4yuibj	245	26	yeast	yeast	NN
cord-321868-xk4yuibj	245	27	genome	genome	NN
cord-321868-xk4yuibj	245	28	(	(	-LRB-
cord-321868-xk4yuibj	245	29	Olson	Olson	NNP
cord-321868-xk4yuibj	245	30	et	et	NNP
cord-321868-xk4yuibj	245	31	al	al	NNP
cord-321868-xk4yuibj	245	32	.	.	NNP
cord-321868-xk4yuibj	245	33	,	,	,
cord-321868-xk4yuibj	245	34	1977	1977	CD
cord-321868-xk4yuibj	245	35	)	)	-RRB-
cord-321868-xk4yuibj	245	36	.	.	.
cord-321868-xk4yuibj	246	1	Burke	Burke	NNP
cord-321868-xk4yuibj	246	2	(	(	-LRB-
cord-321868-xk4yuibj	246	3	1988	1988	CD
cord-321868-xk4yuibj	246	4	)	)	-RRB-
cord-321868-xk4yuibj	246	5	demonstrated	demonstrate	VBD
cord-321868-xk4yuibj	246	6	that	that	IN
cord-321868-xk4yuibj	246	7	the	the	DT
cord-321868-xk4yuibj	246	8	sequential	sequential	JJ
cord-321868-xk4yuibj	246	9	deletion	deletion	NN
cord-321868-xk4yuibj	246	10	of	of	IN
cord-321868-xk4yuibj	246	11	each	each	DT
cord-321868-xk4yuibj	246	12	of	of	IN
cord-321868-xk4yuibj	246	13	the	the	DT
cord-321868-xk4yuibj	246	14	tRNA@	trna@	NN
cord-321868-xk4yuibj	246	15	,	,	,
cord-321868-xk4yuibj	246	16	,	,	,
cord-321868-xk4yuibj	246	17	genetic	genetic	JJ
cord-321868-xk4yuibj	246	18	loci	loci	NN
cord-321868-xk4yuibj	246	19	results	result	NNS
cord-321868-xk4yuibj	246	20	in	in	IN
cord-321868-xk4yuibj	246	21	a	a	DT
cord-321868-xk4yuibj	246	22	linear	linear	JJ
cord-321868-xk4yuibj	246	23	decrease	decrease	NN
cord-321868-xk4yuibj	246	24	in	in	IN
cord-321868-xk4yuibj	246	25	the	the	DT
cord-321868-xk4yuibj	246	26	pool	pool	NN
cord-321868-xk4yuibj	246	27	of	of	IN
cord-321868-xk4yuibj	246	28	aminoacyl	aminoacyl	NNP
cord-321868-xk4yuibj	246	29	-	-	:
cord-321868-xk4yuibj	246	30	tRNATyr	tRNATyr	NNP
cord-321868-xk4yuibj	246	31	within	within	IN
cord-321868-xk4yuibj	246	32	a	a	DT
cord-321868-xk4yuibj	246	33	cell	cell	NN
cord-321868-xk4yuibj	246	34	.	.	.
cord-321868-xk4yuibj	247	1	Deletion	deletion	NN
cord-321868-xk4yuibj	247	2	of	of	IN
cord-321868-xk4yuibj	247	3	up	up	IN
cord-321868-xk4yuibj	247	4	to	to	TO
cord-321868-xk4yuibj	247	5	four	four	CD
cord-321868-xk4yuibj	247	6	of	of	IN
cord-321868-xk4yuibj	247	7	the	the	DT
cord-321868-xk4yuibj	247	8	genes	gene	NNS
cord-321868-xk4yuibj	247	9	has	have	VBZ
cord-321868-xk4yuibj	247	10	no	no	DT
cord-321868-xk4yuibj	247	11	detectable	detectable	JJ
cord-321868-xk4yuibj	247	12	phenotype	phenotype	NN
cord-321868-xk4yuibj	247	13	;	;	:
cord-321868-xk4yuibj	247	14	however	however	RB
cord-321868-xk4yuibj	247	15	,	,	,
cord-321868-xk4yuibj	247	16	deleting	delete	VBG
cord-321868-xk4yuibj	247	17	five	five	CD
cord-321868-xk4yuibj	247	18	results	result	NNS
cord-321868-xk4yuibj	247	19	in	in	IN
cord-321868-xk4yuibj	247	20	a	a	DT
cord-321868-xk4yuibj	247	21	50	50	CD
cord-321868-xk4yuibj	247	22	%	%	NN
cord-321868-xk4yuibj	247	23	increase	increase	NN
cord-321868-xk4yuibj	247	24	in	in	IN
cord-321868-xk4yuibj	247	25	doubling	double	VBG
cord-321868-xk4yuibj	247	26	time	time	NN
cord-321868-xk4yuibj	247	27	,	,	,
cord-321868-xk4yuibj	247	28	deleting	delete	VBG
cord-321868-xk4yuibj	247	29	six	six	CD
cord-321868-xk4yuibj	247	30	increases	increase	NNS
cord-321868-xk4yuibj	247	31	doubling	double	VBG
cord-321868-xk4yuibj	247	32	time	time	NN
cord-321868-xk4yuibj	247	33	by	by	IN
cord-321868-xk4yuibj	247	34	800	800	CD
cord-321868-xk4yuibj	247	35	/	/	SYM
cord-321868-xk4yuibj	247	36	o	o	NN
cord-321868-xk4yuibj	247	37	,	,	,
cord-321868-xk4yuibj	247	38	and	and	CC
cord-321868-xk4yuibj	247	39	deleting	delete	VBG
cord-321868-xk4yuibj	247	40	seven	seven	CD
cord-321868-xk4yuibj	247	41	is	be	VBZ
cord-321868-xk4yuibj	247	42	lethal	lethal	JJ
cord-321868-xk4yuibj	247	43	.	.	.
cord-321868-xk4yuibj	248	1	The	the	DT
cord-321868-xk4yuibj	248	2	increase	increase	NN
cord-321868-xk4yuibj	248	3	in	in	IN
cord-321868-xk4yuibj	248	4	doubling	double	VBG
cord-321868-xk4yuibj	248	5	time	time	NN
cord-321868-xk4yuibj	248	6	unambiguously	unambiguously	RB
cord-321868-xk4yuibj	248	7	indicates	indicate	VBZ
cord-321868-xk4yuibj	248	8	that	that	IN
cord-321868-xk4yuibj	248	9	cell	cell	NN
cord-321868-xk4yuibj	248	10	growth	growth	NN
cord-321868-xk4yuibj	248	11	is	be	VBZ
cord-321868-xk4yuibj	248	12	limited	limit	VBN
cord-321868-xk4yuibj	248	13	by	by	IN
cord-321868-xk4yuibj	248	14	the	the	DT
cord-321868-xk4yuibj	248	15	availability	availability	NN
cord-321868-xk4yuibj	248	16	of	of	IN
cord-321868-xk4yuibj	248	17	the	the	DT
cord-321868-xk4yuibj	248	18	tRNA	trna	NN
cord-321868-xk4yuibj	248	19	,	,	,
cord-321868-xk4yuibj	248	20	suggesting	suggest	VBG
cord-321868-xk4yuibj	248	21	that	that	IN
cord-321868-xk4yuibj	248	22	competition	competition	NN
cord-321868-xk4yuibj	248	23	for	for	IN
cord-321868-xk4yuibj	248	24	the	the	DT
cord-321868-xk4yuibj	248	25	tRNA	trna	NN
cord-321868-xk4yuibj	248	26	would	would	MD
cord-321868-xk4yuibj	248	27	be	be	VB
cord-321868-xk4yuibj	248	28	severe	severe	JJ
cord-321868-xk4yuibj	248	29	in	in	IN
cord-321868-xk4yuibj	248	30	at	at	IN
cord-321868-xk4yuibj	248	31	least	least	JJS
cord-321868-xk4yuibj	248	32	those	those	DT
cord-321868-xk4yuibj	248	33	strains	strain	NNS
cord-321868-xk4yuibj	248	34	.	.	.
cord-321868-xk4yuibj	249	1	We	-PRON-	PRP
cord-321868-xk4yuibj	249	2	introduced	introduce	VBD
cord-321868-xk4yuibj	249	3	a	a	DT
cord-321868-xk4yuibj	249	4	frameshift	frameshift	NN
cord-321868-xk4yuibj	249	5	reporter	reporter	NN
cord-321868-xk4yuibj	249	6	plasmid	plasmid	NN
cord-321868-xk4yuibj	249	7	into	into	IN
cord-321868-xk4yuibj	249	8	strains	strain	NNS
cord-321868-xk4yuibj	249	9	containing	contain	VBG
cord-321868-xk4yuibj	249	10	two	two	CD
cord-321868-xk4yuibj	249	11	to	to	TO
cord-321868-xk4yuibj	249	12	eight	eight	CD
cord-321868-xk4yuibj	249	13	copies	copy	NNS
cord-321868-xk4yuibj	249	14	of	of	IN
cord-321868-xk4yuibj	249	15	the	the	DT
cord-321868-xk4yuibj	249	16	tRN@	trn@	JJ
cord-321868-xk4yuibj	249	17	&	&	CC
cord-321868-xk4yuibj	249	18	genetic	genetic	JJ
cord-321868-xk4yuibj	249	19	loci	locus	NNS
cord-321868-xk4yuibj	249	20	.	.	.
cord-321868-xk4yuibj	250	1	This	this	DT
cord-321868-xk4yuibj	250	2	plasmid	plasmid	NN
cord-321868-xk4yuibj	250	3	contained	contain	VBD
cord-321868-xk4yuibj	250	4	one	one	CD
cord-321868-xk4yuibj	250	5	of	of	IN
cord-321868-xk4yuibj	250	6	three	three	CD
cord-321868-xk4yuibj	250	7	versions	version	NNS
cord-321868-xk4yuibj	250	8	of	of	IN
cord-321868-xk4yuibj	250	9	the	the	DT
cord-321868-xk4yuibj	250	10	9merWT	9merwt	CD
cord-321868-xk4yuibj	250	11	frameshift	frameshift	NN
cord-321868-xk4yuibj	250	12	site	site	NN
cord-321868-xk4yuibj	250	13	:	:	:
cord-321868-xk4yuibj	250	14	one	one	CD
cord-321868-xk4yuibj	250	15	with	with	IN
cord-321868-xk4yuibj	250	16	the	the	DT
cord-321868-xk4yuibj	250	17	wild	wild	JJ
cord-321868-xk4yuibj	250	18	-	-	HYPH
cord-321868-xk4yuibj	250	19	type	type	NN
cord-321868-xk4yuibj	250	20	sequence	sequence	NN
cord-321868-xk4yuibj	250	21	(	(	-LRB-
cord-321868-xk4yuibj	250	22	CUU	CUU	NNP
cord-321868-xk4yuibj	250	23	-	-	HYPH
cord-321868-xk4yuibj	250	24	AGG	AGG	NNP
cord-321868-xk4yuibj	250	25	-	-	HYPH
cord-321868-xk4yuibj	250	26	CCA	CCA	NNP
cord-321868-xk4yuibj	250	27	)	)	-RRB-
cord-321868-xk4yuibj	250	28	,	,	,
cord-321868-xk4yuibj	250	29	one	one	CD
cord-321868-xk4yuibj	250	30	substituting	substitute	VBG
cord-321868-xk4yuibj	250	31	a	a	DT
cord-321868-xk4yuibj	250	32	UAU	UAU	NNP
cord-321868-xk4yuibj	250	33	tyrosine	tyrosine	NN
cord-321868-xk4yuibj	250	34	codon	codon	NN
cord-321868-xk4yuibj	250	35	for	for	IN
cord-321868-xk4yuibj	250	36	AGG	agg	NN
cord-321868-xk4yuibj	250	37	,	,	,
cord-321868-xk4yuibj	250	38	or	or	CC
cord-321868-xk4yuibj	250	39	one	one	NN
cord-321868-xk4yuibj	250	40	substituting	substitute	VBG
cord-321868-xk4yuibj	250	41	the	the	DT
cord-321868-xk4yuibj	250	42	codons	codon	NNS
cord-321868-xk4yuibj	250	43	UUU	UUU	NNP
cord-321868-xk4yuibj	250	44	-	-	HYPH
cord-321868-xk4yuibj	250	45	UAU	UAU	NNP
cord-321868-xk4yuibj	250	46	for	for	IN
cord-321868-xk4yuibj	250	47	CUU	CUU	NNP
cord-321868-xk4yuibj	250	48	-	-	HYPH
cord-321868-xk4yuibj	250	49	AGG	AGG	NNP
cord-321868-xk4yuibj	250	50	(	(	-LRB-
cord-321868-xk4yuibj	250	51	Table	table	NN
cord-321868-xk4yuibj	250	52	5	5	CD
cord-321868-xk4yuibj	250	53	)	)	-RRB-
cord-321868-xk4yuibj	250	54	.	.	.
cord-321868-xk4yuibj	251	1	The	the	DT
cord-321868-xk4yuibj	251	2	second	second	JJ
cord-321868-xk4yuibj	251	3	construct	construct	NN
cord-321868-xk4yuibj	251	4	would	would	MD
cord-321868-xk4yuibj	251	5	require	require	VB
cord-321868-xk4yuibj	251	6	tRNA	tRNA	NNP
cord-321868-xk4yuibj	251	7	&	&	CC
cord-321868-xk4yuibj	251	8	to	to	TO
cord-321868-xk4yuibj	251	9	slip	slip	VB
cord-321868-xk4yuibj	251	10	from	from	IN
cord-321868-xk4yuibj	251	11	CUU	CUU	NNP
cord-321868-xk4yuibj	251	12	(	(	-LRB-
cord-321868-xk4yuibj	251	13	Leu	Leu	NNP
cord-321868-xk4yuibj	251	14	)	)	-RRB-
cord-321868-xk4yuibj	251	15	to	to	IN
cord-321868-xk4yuibj	251	16	UUU	UUU	NNP
cord-321868-xk4yuibj	251	17	(	(	-LRB-
cord-321868-xk4yuibj	251	18	Phe	Phe	NNP
cord-321868-xk4yuibj	251	19	)	)	-RRB-
cord-321868-xk4yuibj	251	20	.	.	.
cord-321868-xk4yuibj	252	1	To	to	TO
cord-321868-xk4yuibj	252	2	make	make	VB
cord-321868-xk4yuibj	252	3	a	a	DT
cord-321868-xk4yuibj	252	4	slip	slip	NN
cord-321868-xk4yuibj	252	5	more	more	RBR
cord-321868-xk4yuibj	252	6	likely	likely	JJ
cord-321868-xk4yuibj	252	7	,	,	,
cord-321868-xk4yuibj	252	8	the	the	DT
cord-321868-xk4yuibj	252	9	last	last	JJ
cord-321868-xk4yuibj	252	10	construct	construct	NN
cord-321868-xk4yuibj	252	11	requires	require	VBZ
cord-321868-xk4yuibj	252	12	tRNA	tRNA	NNP
cord-321868-xk4yuibj	252	13	&	&	CC
cord-321868-xk4yuibj	252	14	to	to	TO
cord-321868-xk4yuibj	252	15	slip	slip	VB
cord-321868-xk4yuibj	252	16	from	from	IN
cord-321868-xk4yuibj	252	17	the	the	DT
cord-321868-xk4yuibj	252	18	0	0	CD
cord-321868-xk4yuibj	252	19	frame	frame	NN
cord-321868-xk4yuibj	252	20	UUU	UUU	NNP
cord-321868-xk4yuibj	252	21	codon	codon	NN
cord-321868-xk4yuibj	252	22	to	to	IN
cord-321868-xk4yuibj	252	23	the	the	DT
cord-321868-xk4yuibj	252	24	+	+	SYM
cord-321868-xk4yuibj	252	25	l	l	NN
cord-321868-xk4yuibj	252	26	frame	frame	NN
cord-321868-xk4yuibj	252	27	UUU	UUU	NNP
cord-321868-xk4yuibj	252	28	codon	codon	NN
cord-321868-xk4yuibj	252	29	to	to	TO
cord-321868-xk4yuibj	252	30	express	express	VB
cord-321868-xk4yuibj	252	31	/acZ.	/acZ.	.
cord-321868-xk4yuibj	253	1	We	-PRON-	PRP
cord-321868-xk4yuibj	253	2	reasoned	reason	VBD
cord-321868-xk4yuibj	253	3	that	that	IN
cord-321868-xk4yuibj	253	4	as	as	IN
cord-321868-xk4yuibj	253	5	the	the	DT
cord-321868-xk4yuibj	253	6	aminoacyl	aminoacyl	NNP
cord-321868-xk4yuibj	253	7	-	-	HYPH
cord-321868-xk4yuibj	253	8	tRNA	tRNA	NNP
cord-321868-xk4yuibj	253	9	&	&	CC
cord-321868-xk4yuibj	253	10	,	,	,
cord-321868-xk4yuibj	253	11	pool	pool	NN
cord-321868-xk4yuibj	253	12	drops	drop	NNS
cord-321868-xk4yuibj	253	13	with	with	IN
cord-321868-xk4yuibj	253	14	decreasing	decrease	VBG
cord-321868-xk4yuibj	253	15	copies	copy	NNS
cord-321868-xk4yuibj	253	16	of	of	IN
cord-321868-xk4yuibj	253	17	the	the	DT
cord-321868-xk4yuibj	253	18	tRNA	tRNA	NNP
cord-321868-xk4yuibj	253	19	&	&	CC
cord-321868-xk4yuibj	253	20	,	,	,
cord-321868-xk4yuibj	253	21	gene	gene	NN
cord-321868-xk4yuibj	253	22	,	,	,
cord-321868-xk4yuibj	253	23	the	the	DT
cord-321868-xk4yuibj	253	24	possibility	possibility	NN
cord-321868-xk4yuibj	253	25	of	of	IN
cord-321868-xk4yuibj	253	26	a	a	DT
cord-321868-xk4yuibj	253	27	translational	translational	JJ
cord-321868-xk4yuibj	253	28	pause	pause	NN
cord-321868-xk4yuibj	253	29	at	at	IN
cord-321868-xk4yuibj	253	30	the	the	DT
cord-321868-xk4yuibj	253	31	UAU	UAU	NNP
cord-321868-xk4yuibj	253	32	codon	codon	NN
cord-321868-xk4yuibj	253	33	would	would	MD
cord-321868-xk4yuibj	253	34	increase	increase	VB
cord-321868-xk4yuibj	253	35	because	because	IN
cord-321868-xk4yuibj	253	36	of	of	IN
cord-321868-xk4yuibj	253	37	the	the	DT
cord-321868-xk4yuibj	253	38	apparent	apparent	JJ
cord-321868-xk4yuibj	253	39	severe	severe	JJ
cord-321868-xk4yuibj	253	40	competition	competition	NN
cord-321868-xk4yuibj	253	41	for	for	IN
cord-321868-xk4yuibj	253	42	the	the	DT
cord-321868-xk4yuibj	253	43	tRNA	tRNA	NNP
cord-321868-xk4yuibj	253	44	.	.	.
cord-321868-xk4yuibj	254	1	This	this	DT
cord-321868-xk4yuibj	254	2	pause	pause	NN
cord-321868-xk4yuibj	254	3	may	may	MD
cord-321868-xk4yuibj	254	4	allow	allow	VB
cord-321868-xk4yuibj	254	5	a	a	DT
cord-321868-xk4yuibj	254	6	frameshift	frameshift	NN
cord-321868-xk4yuibj	254	7	event	event	NN
cord-321868-xk4yuibj	254	8	to	to	TO
cord-321868-xk4yuibj	254	9	occur	occur	VB
cord-321868-xk4yuibj	254	10	at	at	IN
cord-321868-xk4yuibj	254	11	the	the	DT
cord-321868-xk4yuibj	254	12	upstream	upstream	JJ
cord-321868-xk4yuibj	254	13	codon	codon	NN
cord-321868-xk4yuibj	254	14	.	.	.
cord-321868-xk4yuibj	255	1	The	the	DT
cord-321868-xk4yuibj	255	2	results	result	NNS
cord-321868-xk4yuibj	255	3	are	be	VBP
cord-321868-xk4yuibj	255	4	displayed	display	VBN
cord-321868-xk4yuibj	255	5	in	in	IN
cord-321868-xk4yuibj	255	6	Table	Table	NNP
cord-321868-xk4yuibj	255	7	5	5	CD
cord-321868-xk4yuibj	255	8	.	.	.
cord-321868-xk4yuibj	256	1	Neither	neither	DT
cord-321868-xk4yuibj	256	2	construct	construct	VB
cord-321868-xk4yuibj	256	3	incorporating	incorporate	VBG
cord-321868-xk4yuibj	256	4	a	a	DT
cord-321868-xk4yuibj	256	5	UAU	UAU	NNP
cord-321868-xk4yuibj	256	6	"	"	``
cord-321868-xk4yuibj	256	7	pause	pause	NN
cord-321868-xk4yuibj	256	8	"	"	''
cord-321868-xk4yuibj	256	9	codon	codon	NN
cord-321868-xk4yuibj	256	10	allows	allow	VBZ
cord-321868-xk4yuibj	256	11	appreciable	appreciable	JJ
cord-321868-xk4yuibj	256	12	levels	level	NNS
cord-321868-xk4yuibj	256	13	of	of	IN
cord-321868-xk4yuibj	256	14	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	256	15	in	in	IN
cord-321868-xk4yuibj	256	16	any	any	DT
cord-321868-xk4yuibj	256	17	of	of	IN
cord-321868-xk4yuibj	256	18	the	the	DT
cord-321868-xk4yuibj	256	19	deletion	deletion	NN
cord-321868-xk4yuibj	256	20	strains	strain	NNS
cord-321868-xk4yuibj	256	21	,	,	,
cord-321868-xk4yuibj	256	22	while	while	IN
cord-321868-xk4yuibj	256	23	the	the	DT
cord-321868-xk4yuibj	256	24	wild	wild	JJ
cord-321868-xk4yuibj	256	25	-	-	HYPH
cord-321868-xk4yuibj	256	26	type	type	NN
cord-321868-xk4yuibj	256	27	construct	construct	NN
cord-321868-xk4yuibj	256	28	shows	show	VBZ
cord-321868-xk4yuibj	256	29	normal	normal	JJ
cord-321868-xk4yuibj	256	30	amounts	amount	NNS
cord-321868-xk4yuibj	256	31	of	of	IN
cord-321868-xk4yuibj	256	32	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	256	33	.	.	.
cord-321868-xk4yuibj	257	1	We	-PRON-	PRP
cord-321868-xk4yuibj	257	2	conclude	conclude	VBP
cord-321868-xk4yuibj	257	3	from	from	IN
cord-321868-xk4yuibj	257	4	these	these	DT
cord-321868-xk4yuibj	257	5	data	datum	NNS
cord-321868-xk4yuibj	257	6	that	that	WDT
cord-321868-xk4yuibj	257	7	the	the	DT
cord-321868-xk4yuibj	257	8	fact	fact	NN
cord-321868-xk4yuibj	257	9	that	that	IN
cord-321868-xk4yuibj	257	10	a	a	DT
cord-321868-xk4yuibj	257	11	codon	codon	NN
cord-321868-xk4yuibj	257	12	is	be	VBZ
cord-321868-xk4yuibj	257	13	decoded	decode	VBN
cord-321868-xk4yuibj	257	14	by	by	IN
cord-321868-xk4yuibj	257	15	a	a	DT
cord-321868-xk4yuibj	257	16	limiting	limit	VBG
cord-321868-xk4yuibj	257	17	tRNA	trna	NN
cord-321868-xk4yuibj	257	18	in	in	IN
cord-321868-xk4yuibj	257	19	itself	-PRON-	PRP
cord-321868-xk4yuibj	257	20	is	be	VBZ
cord-321868-xk4yuibj	257	21	not	not	RB
cord-321868-xk4yuibj	257	22	sufficient	sufficient	JJ
cord-321868-xk4yuibj	257	23	to	to	TO
cord-321868-xk4yuibj	257	24	cause	cause	VB
cord-321868-xk4yuibj	257	25	a	a	DT
cord-321868-xk4yuibj	257	26	translational	translational	JJ
cord-321868-xk4yuibj	257	27	pause	pause	NN
cord-321868-xk4yuibj	257	28	capable	capable	JJ
cord-321868-xk4yuibj	257	29	of	of	IN
cord-321868-xk4yuibj	257	30	inducing	induce	VBG
cord-321868-xk4yuibj	257	31	detectable	detectable	JJ
cord-321868-xk4yuibj	257	32	translational	translational	JJ
cord-321868-xk4yuibj	257	33	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	257	34	.	.	.
cord-321868-xk4yuibj	258	1	Is	be	VBZ
cord-321868-xk4yuibj	258	2	Inhibited	inhibit	VBN
cord-321868-xk4yuibj	258	3	by	by	IN
cord-321868-xk4yuibj	258	4	Proximity	Proximity	NNP
cord-321868-xk4yuibj	258	5	to	to	IN
cord-321868-xk4yuibj	258	6	the	the	DT
cord-321868-xk4yuibj	258	7	Initiation	Initiation	NNP
cord-321868-xk4yuibj	258	8	Codon	Codon	NNP
cord-321868-xk4yuibj	259	1	We	-PRON-	PRP
cord-321868-xk4yuibj	259	2	previously	previously	RB
cord-321868-xk4yuibj	259	3	demonstrated	demonstrate	VBD
cord-321868-xk4yuibj	259	4	that	that	IN
cord-321868-xk4yuibj	259	5	placing	place	VBG
cord-321868-xk4yuibj	259	6	the	the	DT
cord-321868-xk4yuibj	259	7	14	14	CD
cord-321868-xk4yuibj	259	8	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	259	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	259	10	site	site	NN
cord-321868-xk4yuibj	259	11	in	in	IN
cord-321868-xk4yuibj	259	12	immediate	immediate	JJ
cord-321868-xk4yuibj	259	13	proximity	proximity	NN
cord-321868-xk4yuibj	259	14	to	to	IN
cord-321868-xk4yuibj	259	15	the	the	DT
cord-321868-xk4yuibj	259	16	translational	translational	JJ
cord-321868-xk4yuibj	259	17	initiation	initiation	NN
cord-321868-xk4yuibj	259	18	codon	codon	NNP
cord-321868-xk4yuibj	259	19	inhibits	inhibit	VBZ
cord-321868-xk4yuibj	259	20	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	259	21	(	(	-LRB-
cord-321868-xk4yuibj	259	22	Clare	Clare	NNP
cord-321868-xk4yuibj	259	23	et	et	NNP
cord-321868-xk4yuibj	259	24	al	al	NNP
cord-321868-xk4yuibj	259	25	.	.	NNP
cord-321868-xk4yuibj	259	26	,	,	,
cord-321868-xk4yuibj	259	27	1988	1988	CD
cord-321868-xk4yuibj	259	28	)	)	-RRB-
cord-321868-xk4yuibj	259	29	.	.	.
cord-321868-xk4yuibj	260	1	Placing	place	VBG
cord-321868-xk4yuibj	260	2	the	the	DT
cord-321868-xk4yuibj	260	3	CUU	CUU	NNP
cord-321868-xk4yuibj	260	4	codon	codon	NN
cord-321868-xk4yuibj	260	5	of	of	IN
cord-321868-xk4yuibj	260	6	the	the	DT
cord-321868-xk4yuibj	260	7	frameshift	frameshift	NN
cord-321868-xk4yuibj	260	8	site	site	NN
cord-321868-xk4yuibj	260	9	three	three	CD
cord-321868-xk4yuibj	260	10	codons	codon	NNS
cord-321868-xk4yuibj	260	11	downstream	downstream	RB
cord-321868-xk4yuibj	260	12	of	of	IN
cord-321868-xk4yuibj	260	13	the	the	DT
cord-321868-xk4yuibj	260	14	Ty2	ty2	CD
cord-321868-xk4yuibj	260	15	-	-	SYM
cord-321868-xk4yuibj	260	16	917	917	CD
cord-321868-xk4yuibj	260	17	AUG	AUG	NNP
cord-321868-xk4yuibj	260	18	codon	codon	NN
cord-321868-xk4yuibj	260	19	abolished	abolish	VBD
cord-321868-xk4yuibj	260	20	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	260	21	.	.	.
cord-321868-xk4yuibj	261	1	When	when	WRB
cord-321868-xk4yuibj	261	2	this	this	DT
cord-321868-xk4yuibj	261	3	codon	codon	NN
cord-321868-xk4yuibj	261	4	was	be	VBD
cord-321868-xk4yuibj	261	5	positioned	position	VBN
cord-321868-xk4yuibj	261	6	31	31	CD
cord-321868-xk4yuibj	261	7	codons	codon	NNS
cord-321868-xk4yuibj	261	8	downstream	downstream	NN
cord-321868-xk4yuibj	261	9	,	,	,
cord-321868-xk4yuibj	261	10	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	261	11	was	be	VBD
cord-321868-xk4yuibj	261	12	restored	restore	VBN
cord-321868-xk4yuibj	261	13	.	.	.
cord-321868-xk4yuibj	262	1	This	this	DT
cord-321868-xk4yuibj	262	2	suppression	suppression	NN
cord-321868-xk4yuibj	262	3	could	could	MD
cord-321868-xk4yuibj	262	4	be	be	VB
cord-321868-xk4yuibj	262	5	a	a	DT
cord-321868-xk4yuibj	262	6	context	context	NN
cord-321868-xk4yuibj	262	7	effect	effect	NN
cord-321868-xk4yuibj	262	8	around	around	IN
cord-321868-xk4yuibj	262	9	the	the	DT
cord-321868-xk4yuibj	262	10	Ty2	ty2	CD
cord-321868-xk4yuibj	262	11	-	-	HYPH
cord-321868-xk4yuibj	262	12	917	917	CD
cord-321868-xk4yuibj	262	13	initiation	initiation	NN
cord-321868-xk4yuibj	262	14	codon	codon	NN
cord-321868-xk4yuibj	262	15	(	(	-LRB-
cord-321868-xk4yuibj	262	16	in	in	IN
cord-321868-xk4yuibj	262	17	which	which	WDT
cord-321868-xk4yuibj	262	18	case	case	NN
cord-321868-xk4yuibj	262	19	the	the	DT
cord-321868-xk4yuibj	262	20	sequence	sequence	NN
cord-321868-xk4yuibj	262	21	around	around	IN
cord-321868-xk4yuibj	262	22	the	the	DT
cord-321868-xk4yuibj	262	23	initiation	initiation	NN
cord-321868-xk4yuibj	262	24	codon	codon	NN
cord-321868-xk4yuibj	262	25	would	would	MD
cord-321868-xk4yuibj	262	26	suppress	suppress	VB
cord-321868-xk4yuibj	262	27	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	262	28	even	even	RB
cord-321868-xk4yuibj	262	29	if	if	IN
cord-321868-xk4yuibj	262	30	positioned	position	VBN
cord-321868-xk4yuibj	262	31	far	far	RB
cord-321868-xk4yuibj	262	32	downstream	downstream	RB
cord-321868-xk4yuibj	262	33	within	within	IN
cord-321868-xk4yuibj	262	34	a	a	DT
cord-321868-xk4yuibj	262	35	gene	gene	NN
cord-321868-xk4yuibj	262	36	)	)	-RRB-
cord-321868-xk4yuibj	262	37	,	,	,
cord-321868-xk4yuibj	262	38	or	or	CC
cord-321868-xk4yuibj	262	39	it	-PRON-	PRP
cord-321868-xk4yuibj	262	40	could	could	MD
cord-321868-xk4yuibj	262	41	be	be	VB
cord-321868-xk4yuibj	262	42	an	an	DT
cord-321868-xk4yuibj	262	43	effect	effect	NN
cord-321868-xk4yuibj	262	44	of	of	IN
cord-321868-xk4yuibj	262	45	initiation	initiation	NN
cord-321868-xk4yuibj	262	46	itself	-PRON-	PRP
cord-321868-xk4yuibj	262	47	.	.	.
cord-321868-xk4yuibj	263	1	To	to	TO
cord-321868-xk4yuibj	263	2	test	test	VB
cord-321868-xk4yuibj	263	3	the	the	DT
cord-321868-xk4yuibj	263	4	former	former	JJ
cord-321868-xk4yuibj	263	5	possibility	possibility	NN
cord-321868-xk4yuibj	263	6	,	,	,
cord-321868-xk4yuibj	263	7	we	-PRON-	PRP
cord-321868-xk4yuibj	263	8	synthesized	synthesize	VBD
cord-321868-xk4yuibj	263	9	an	an	DT
cord-321868-xk4yuibj	263	10	oligonucleotide	oligonucleotide	JJ
cord-321868-xk4yuibj	263	11	encompassing	encompass	VBG
cord-321868-xk4yuibj	263	12	a	a	DT
cord-321868-xk4yuibj	263	13	region	region	NN
cord-321868-xk4yuibj	263	14	from	from	IN
cord-321868-xk4yuibj	263	15	15	15	CD
cord-321868-xk4yuibj	263	16	bp	bp	NNP
cord-321868-xk4yuibj	263	17	upstream	upstream	RB
cord-321868-xk4yuibj	263	18	of	of	IN
cord-321868-xk4yuibj	263	19	the	the	DT
cord-321868-xk4yuibj	263	20	Ty2	ty2	CD
cord-321868-xk4yuibj	263	21	-	-	SYM
cord-321868-xk4yuibj	263	22	917	917	CD
cord-321868-xk4yuibj	263	23	AUG	AUG	NNP
cord-321868-xk4yuibj	263	24	,	,	,
cord-321868-xk4yuibj	263	25	through	through	IN
cord-321868-xk4yuibj	263	26	the	the	DT
cord-321868-xk4yuibj	263	27	14	14	CD
cord-321868-xk4yuibj	263	28	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	263	29	frameshift	frameshift	NN
cord-321868-xk4yuibj	263	30	site	site	NN
cord-321868-xk4yuibj	263	31	(	(	-LRB-
cord-321868-xk4yuibj	263	32	which	which	WDT
cord-321868-xk4yuibj	263	33	was	be	VBD
cord-321868-xk4yuibj	263	34	fused	fuse	VBN
cord-321868-xk4yuibj	263	35	at	at	IN
cord-321868-xk4yuibj	263	36	the	the	DT
cord-321868-xk4yuibj	263	37	Ty2	ty2	CD
cord-321868-xk4yuibj	263	38	-	-	SYM
cord-321868-xk4yuibj	263	39	917	917	CD
cord-321868-xk4yuibj	263	40	AUG	AUG	NNP
cord-321868-xk4yuibj	263	41	)	)	-RRB-
cord-321868-xk4yuibj	263	42	,	,	,
cord-321868-xk4yuibj	263	43	and	and	CC
cord-321868-xk4yuibj	263	44	15	15	CD
cord-321868-xk4yuibj	263	45	bp	bp	NNP
cord-321868-xk4yuibj	263	46	downstream	downstream	NNP
cord-321868-xk4yuibj	263	47	.	.	.
cord-321868-xk4yuibj	264	1	The	the	DT
cord-321868-xk4yuibj	264	2	oligonucleotide	oligonucleotide	NN
cord-321868-xk4yuibj	264	3	,	,	,
cord-321868-xk4yuibj	264	4	when	when	WRB
cord-321868-xk4yuibj	264	5	inserted	insert	VBN
cord-321868-xk4yuibj	264	6	between	between	IN
cord-321868-xk4yuibj	264	7	a	a	DT
cord-321868-xk4yuibj	264	8	NA917deletion	NA917deletion	NNP
cord-321868-xk4yuibj	264	9	929	929	CD
cord-321868-xk4yuibj	264	10	bp	bp	NNP
cord-321868-xk4yuibj	264	11	downstream	downstream	NN
cord-321868-xk4yuibj	264	12	of	of	IN
cord-321868-xk4yuibj	264	13	the	the	DT
cord-321868-xk4yuibj	264	14	initiation	initiation	NN
cord-321868-xk4yuibj	264	15	codon	codon	NN
cord-321868-xk4yuibj	264	16	and	and	CC
cord-321868-xk4yuibj	264	17	the	the	DT
cord-321868-xk4yuibj	264	18	/acZ	/acZ	NNP
cord-321868-xk4yuibj	264	19	gene	gene	NN
cord-321868-xk4yuibj	264	20	(	(	-LRB-
cord-321868-xk4yuibj	264	21	in	in	IN
cord-321868-xk4yuibj	264	22	the	the	DT
cord-321868-xk4yuibj	264	23	+	+	CC
cord-321868-xk4yuibj	264	24	l	l	NN
cord-321868-xk4yuibj	264	25	reading	reading	NN
cord-321868-xk4yuibj	264	26	frame	frame	NN
cord-321868-xk4yuibj	264	27	)	)	-RRB-
cord-321868-xk4yuibj	264	28	,	,	,
cord-321868-xk4yuibj	264	29	supported	support	VBD
cord-321868-xk4yuibj	264	30	normal	normal	JJ
cord-321868-xk4yuibj	264	31	levels	level	NNS
cord-321868-xk4yuibj	264	32	of	of	IN
cord-321868-xk4yuibj	264	33	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	264	34	(	(	-LRB-
cord-321868-xk4yuibj	264	35	data	datum	NNS
cord-321868-xk4yuibj	264	36	not	not	RB
cord-321868-xk4yuibj	264	37	shown	show	VBN
cord-321868-xk4yuibj	264	38	)	)	-RRB-
cord-321868-xk4yuibj	264	39	.	.	.
cord-321868-xk4yuibj	265	1	This	this	DT
cord-321868-xk4yuibj	265	2	suggests	suggest	VBZ
cord-321868-xk4yuibj	265	3	that	that	IN
cord-321868-xk4yuibj	265	4	proximity	proximity	NN
cord-321868-xk4yuibj	265	5	alone	alone	RB
cord-321868-xk4yuibj	265	6	causes	cause	VBZ
cord-321868-xk4yuibj	265	7	the	the	DT
cord-321868-xk4yuibj	265	8	suppression	suppression	NN
cord-321868-xk4yuibj	265	9	of	of	IN
cord-321868-xk4yuibj	265	10	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	265	11	.	.	.
cord-321868-xk4yuibj	266	1	To	to	TO
cord-321868-xk4yuibj	266	2	determine	determine	VB
cord-321868-xk4yuibj	266	3	the	the	DT
cord-321868-xk4yuibj	266	4	minimal	minimal	JJ
cord-321868-xk4yuibj	266	5	distance	distance	NN
cord-321868-xk4yuibj	266	6	between	between	IN
cord-321868-xk4yuibj	266	7	the	the	DT
cord-321868-xk4yuibj	266	8	AUG	AUG	NNP
cord-321868-xk4yuibj	266	9	initiation	initiation	NN
cord-321868-xk4yuibj	266	10	codon	codon	NN
cord-321868-xk4yuibj	266	11	and	and	CC
cord-321868-xk4yuibj	266	12	the	the	DT
cord-321868-xk4yuibj	266	13	14	14	CD
cord-321868-xk4yuibj	266	14	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	266	15	frameshift	frameshift	NN
cord-321868-xk4yuibj	266	16	site	site	NN
cord-321868-xk4yuibj	266	17	,	,	,
cord-321868-xk4yuibj	266	18	we	-PRON-	PRP
cord-321868-xk4yuibj	266	19	placed	place	VBD
cord-321868-xk4yuibj	266	20	the	the	DT
cord-321868-xk4yuibj	266	21	frameshift	frameshift	NN
cord-321868-xk4yuibj	266	22	site	site	NN
cord-321868-xk4yuibj	266	23	at	at	IN
cord-321868-xk4yuibj	266	24	increasingly	increasingly	RB
cord-321868-xk4yuibj	266	25	farther	farther	JJ
cord-321868-xk4yuibj	266	26	codon	codon	NN
cord-321868-xk4yuibj	266	27	intervals	interval	NNS
cord-321868-xk4yuibj	266	28	from	from	IN
cord-321868-xk4yuibj	266	29	the	the	DT
cord-321868-xk4yuibj	266	30	HEM	HEM	NNP
cord-321868-xk4yuibj	266	31	initiation	initiation	NN
cord-321868-xk4yuibj	266	32	codon	codon	NN
cord-321868-xk4yuibj	266	33	.	.	.
cord-321868-xk4yuibj	267	1	BamHl	BamHl	NNP
cord-321868-xk4yuibj	267	2	sites	site	NNS
cord-321868-xk4yuibj	267	3	were	be	VBD
cord-321868-xk4yuibj	267	4	introduced	introduce	VBN
cord-321868-xk4yuibj	267	5	in	in	IN
cord-321868-xk4yuibj	267	6	the	the	DT
cord-321868-xk4yuibj	267	7	HIS4A	HIS4A	NNP
cord-321868-xk4yuibj	267	8	gene	gene	NN
cord-321868-xk4yuibj	267	9	at	at	IN
cord-321868-xk4yuibj	267	10	codon	codon	NN
cord-321868-xk4yuibj	267	11	intervals	interval	NNS
cord-321868-xk4yuibj	267	12	beginning	begin	VBG
cord-321868-xk4yuibj	267	13	at	at	IN
cord-321868-xk4yuibj	267	14	the	the	DT
cord-321868-xk4yuibj	267	15	second	second	JJ
cord-321868-xk4yuibj	267	16	codon	codon	NN
cord-321868-xk4yuibj	267	17	and	and	CC
cord-321868-xk4yuibj	267	18	ending	end	VBG
cord-321868-xk4yuibj	267	19	at	at	IN
cord-321868-xk4yuibj	267	20	the	the	DT
cord-321868-xk4yuibj	267	21	seventh	seventh	JJ
cord-321868-xk4yuibj	267	22	codon	codon	NN
cord-321868-xk4yuibj	267	23	as	as	IN
cord-321868-xk4yuibj	267	24	described	describe	VBN
cord-321868-xk4yuibj	267	25	in	in	IN
cord-321868-xk4yuibj	267	26	Experimental	Experimental	NNP
cord-321868-xk4yuibj	267	27	Procedures	procedure	NNS
cord-321868-xk4yuibj	267	28	.	.	.
cord-321868-xk4yuibj	268	1	Introduction	introduction	NN
cord-321868-xk4yuibj	268	2	of	of	IN
cord-321868-xk4yuibj	268	3	the	the	DT
cord-321868-xk4yuibj	268	4	14	14	CD
cord-321868-xk4yuibj	268	5	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	268	6	frameshift	frameshift	NN
cord-321868-xk4yuibj	268	7	sequence	sequence	NN
cord-321868-xk4yuibj	268	8	into	into	IN
cord-321868-xk4yuibj	268	9	each	each	DT
cord-321868-xk4yuibj	268	10	of	of	IN
cord-321868-xk4yuibj	268	11	the	the	DT
cord-321868-xk4yuibj	268	12	six	six	CD
cord-321868-xk4yuibj	268	13	"	"	``
cord-321868-xk4yuibj	268	14	proximity	proximity	NN
cord-321868-xk4yuibj	268	15	constructs	construct	NNS
cord-321868-xk4yuibj	268	16	"	"	''
cord-321868-xk4yuibj	268	17	allowed	allow	VBD
cord-321868-xk4yuibj	268	18	a	a	DT
cord-321868-xk4yuibj	268	19	measure	measure	NN
cord-321868-xk4yuibj	268	20	of	of	IN
cord-321868-xk4yuibj	268	21	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	268	22	into	into	IN
cord-321868-xk4yuibj	268	23	the	the	DT
cord-321868-xk4yuibj	268	24	downstream	downstream	NN
cord-321868-xk4yuibj	268	25	/acZ	/acZ	NNP
cord-321868-xk4yuibj	268	26	gene	gene	NN
cord-321868-xk4yuibj	268	27	.	.	.
cord-321868-xk4yuibj	269	1	As	as	IN
cord-321868-xk4yuibj	269	2	we	-PRON-	PRP
cord-321868-xk4yuibj	269	3	saw	see	VBD
cord-321868-xk4yuibj	269	4	with	with	IN
cord-321868-xk4yuibj	269	5	the	the	DT
cord-321868-xk4yuibj	269	6	Ty2	ty2	CD
cord-321868-xk4yuibj	269	7	-	-	SYM
cord-321868-xk4yuibj	269	8	917	917	CD
cord-321868-xk4yuibj	269	9	construct	construct	NN
cord-321868-xk4yuibj	269	10	,	,	,
cord-321868-xk4yuibj	269	11	placement	placement	NN
cord-321868-xk4yuibj	269	12	of	of	IN
cord-321868-xk4yuibj	269	13	the	the	DT
cord-321868-xk4yuibj	269	14	CUU	CUU	NNP
cord-321868-xk4yuibj	269	15	codon	codon	NN
cord-321868-xk4yuibj	269	16	of	of	IN
cord-321868-xk4yuibj	269	17	the	the	DT
cord-321868-xk4yuibj	269	18	frameshift	frameshift	NN
cord-321868-xk4yuibj	269	19	site	site	NN
cord-321868-xk4yuibj	269	20	three	three	CD
cord-321868-xk4yuibj	269	21	codons	codon	NNS
cord-321868-xk4yuibj	269	22	downstream	downstream	RB
cord-321868-xk4yuibj	269	23	of	of	IN
cord-321868-xk4yuibj	269	24	the	the	DT
cord-321868-xk4yuibj	269	25	HIS4	HIS4	NNP
cord-321868-xk4yuibj	269	26	AUG	AUG	NNP
cord-321868-xk4yuibj	269	27	in	in	IN
cord-321868-xk4yuibj	269	28	construction	construction	NN
cord-321868-xk4yuibj	269	29	p2p	p2p	NN
cord-321868-xk4yuibj	269	30	resulted	result	VBD
cord-321868-xk4yuibj	269	31	in	in	IN
cord-321868-xk4yuibj	269	32	no	no	DT
cord-321868-xk4yuibj	269	33	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	269	34	(	(	-LRB-
cord-321868-xk4yuibj	269	35	Table	Table	NNP
cord-321868-xk4yuibj	269	36	6	6	CD
cord-321868-xk4yuibj	269	37	)	)	-RRB-
cord-321868-xk4yuibj	269	38	.	.	.
cord-321868-xk4yuibj	270	1	However	however	RB
cord-321868-xk4yuibj	270	2	,	,	,
cord-321868-xk4yuibj	270	3	construction	construction	NN
cord-321868-xk4yuibj	270	4	p3p	p3p	NN
cord-321868-xk4yuibj	270	5	,	,	,
cord-321868-xk4yuibj	270	6	which	which	WDT
cord-321868-xk4yuibj	270	7	places	place	VBZ
cord-321868-xk4yuibj	270	8	the	the	DT
cord-321868-xk4yuibj	270	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	270	10	site	site	NN
cord-321868-xk4yuibj	270	11	at	at	IN
cord-321868-xk4yuibj	270	12	a	a	DT
cord-321868-xk4yuibj	270	13	position	position	NN
cord-321868-xk4yuibj	270	14	four	four	CD
cord-321868-xk4yuibj	270	15	codons	codon	NNS
cord-321868-xk4yuibj	270	16	downstream	downstream	RB
cord-321868-xk4yuibj	270	17	,	,	,
cord-321868-xk4yuibj	270	18	shows	show	VBZ
cord-321868-xk4yuibj	270	19	appreciable	appreciable	JJ
cord-321868-xk4yuibj	270	20	levels	level	NNS
cord-321868-xk4yuibj	270	21	of	of	IN
cord-321868-xk4yuibj	270	22	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	270	23	,	,	,
cord-321868-xk4yuibj	270	24	with	with	IN
cord-321868-xk4yuibj	270	25	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	270	26	occurring	occur	VBG
cord-321868-xk4yuibj	270	27	at	at	IN
cord-321868-xk4yuibj	270	28	about	about	RB
cord-321868-xk4yuibj	270	29	70	70	CD
cord-321868-xk4yuibj	270	30	/	/	SYM
cord-321868-xk4yuibj	270	31	o	o	NN
cord-321868-xk4yuibj	270	32	.	.	.
cord-321868-xk4yuibj	271	1	Placement	placement	NN
cord-321868-xk4yuibj	271	2	of	of	IN
cord-321868-xk4yuibj	271	3	the	the	DT
cord-321868-xk4yuibj	271	4	site	site	NN
cord-321868-xk4yuibj	271	5	five	five	CD
cord-321868-xk4yuibj	271	6	,	,	,
cord-321868-xk4yuibj	271	7	six	six	CD
cord-321868-xk4yuibj	271	8	,	,	,
cord-321868-xk4yuibj	271	9	seven	seven	CD
cord-321868-xk4yuibj	271	10	,	,	,
cord-321868-xk4yuibj	271	11	or	or	CC
cord-321868-xk4yuibj	271	12	eight	eight	CD
cord-321868-xk4yuibj	271	13	codons	codon	NNS
cord-321868-xk4yuibj	271	14	downstream	downstream	RB
cord-321868-xk4yuibj	271	15	of	of	IN
cord-321868-xk4yuibj	271	16	the	the	DT
cord-321868-xk4yuibj	271	17	AUG	AUG	NNP
cord-321868-xk4yuibj	271	18	codon	codon	NN
cord-321868-xk4yuibj	271	19	showed	show	VBD
cord-321868-xk4yuibj	271	20	frameshift	frameshift	NN
cord-321868-xk4yuibj	271	21	activity	activity	NN
cord-321868-xk4yuibj	271	22	at	at	IN
cord-321868-xk4yuibj	271	23	near	near	IN
cord-321868-xk4yuibj	271	24	wild	wild	JJ
cord-321868-xk4yuibj	271	25	-	-	HYPH
cord-321868-xk4yuibj	271	26	type	type	NN
cord-321868-xk4yuibj	271	27	levels	level	NNS
cord-321868-xk4yuibj	271	28	.	.	.
cord-321868-xk4yuibj	272	1	We	-PRON-	PRP
cord-321868-xk4yuibj	272	2	hypothesize	hypothesize	VBP
cord-321868-xk4yuibj	272	3	that	that	IN
cord-321868-xk4yuibj	272	4	the	the	DT
cord-321868-xk4yuibj	272	5	ribosome	ribosome	NN
cord-321868-xk4yuibj	272	6	becomes	become	VBZ
cord-321868-xk4yuibj	272	7	competent	competent	JJ
cord-321868-xk4yuibj	272	8	to	to	TO
cord-321868-xk4yuibj	272	9	frameshift	frameshift	VB
cord-321868-xk4yuibj	272	10	during	during	IN
cord-321868-xk4yuibj	272	11	the	the	DT
cord-321868-xk4yuibj	272	12	initial	initial	JJ
cord-321868-xk4yuibj	272	13	stages	stage	NNS
cord-321868-xk4yuibj	272	14	of	of	IN
cord-321868-xk4yuibj	272	15	elongation	elongation	NN
cord-321868-xk4yuibj	272	16	following	follow	VBG
cord-321868-xk4yuibj	272	17	initiation	initiation	NN
cord-321868-xk4yuibj	272	18	,	,	,
cord-321868-xk4yuibj	272	19	apparently	apparently	RB
cord-321868-xk4yuibj	272	20	with	with	IN
cord-321868-xk4yuibj	272	21	an	an	DT
cord-321868-xk4yuibj	272	22	abrupt	abrupt	JJ
cord-321868-xk4yuibj	272	23	transition	transition	NN
cord-321868-xk4yuibj	272	24	after	after	IN
cord-321868-xk4yuibj	272	25	the	the	DT
cord-321868-xk4yuibj	272	26	fourth	fourth	JJ
cord-321868-xk4yuibj	272	27	codon	codon	NN
cord-321868-xk4yuibj	272	28	of	of	IN
cord-321868-xk4yuibj	272	29	the	the	DT
cord-321868-xk4yuibj	272	30	gene	gene	NN
cord-321868-xk4yuibj	272	31	.	.	.
cord-321868-xk4yuibj	273	1	Translation	translation	NN
cord-321868-xk4yuibj	273	2	initiation	initiation	NN
cord-321868-xk4yuibj	273	3	in	in	IN
cord-321868-xk4yuibj	273	4	eukaryotes	eukaryote	NNS
cord-321868-xk4yuibj	273	5	occurs	occur	VBZ
cord-321868-xk4yuibj	273	6	by	by	IN
cord-321868-xk4yuibj	273	7	a	a	DT
cord-321868-xk4yuibj	273	8	mechanism	mechanism	NN
cord-321868-xk4yuibj	273	9	fundamentally	fundamentally	RB
cord-321868-xk4yuibj	273	10	different	different	JJ
cord-321868-xk4yuibj	273	11	from	from	IN
cord-321868-xk4yuibj	273	12	that	that	DT
cord-321868-xk4yuibj	273	13	in	in	IN
cord-321868-xk4yuibj	273	14	prokaryotes	prokaryote	NNS
cord-321868-xk4yuibj	273	15	.	.	.
cord-321868-xk4yuibj	274	1	The	the	DT
cord-321868-xk4yuibj	274	2	ribosome	ribosome	NN
cord-321868-xk4yuibj	274	3	binds	bind	VBZ
cord-321868-xk4yuibj	274	4	to	to	IN
cord-321868-xk4yuibj	274	5	the	the	DT
cord-321868-xk4yuibj	274	6	5	5	CD
cord-321868-xk4yuibj	274	7	'	'	NN
cord-321868-xk4yuibj	274	8	end	end	NN
cord-321868-xk4yuibj	274	9	of	of	IN
cord-321868-xk4yuibj	274	10	the	the	DT
cord-321868-xk4yuibj	274	11	mRNA	mrna	NN
cord-321868-xk4yuibj	274	12	and	and	CC
cord-321868-xk4yuibj	274	13	"	"	``
cord-321868-xk4yuibj	274	14	scans	scan	NNS
cord-321868-xk4yuibj	274	15	"	"	''
cord-321868-xk4yuibj	274	16	to	to	IN
cord-321868-xk4yuibj	274	17	the	the	DT
cord-321868-xk4yuibj	274	18	initiation	initiation	NN
cord-321868-xk4yuibj	274	19	codon	codon	NN
cord-321868-xk4yuibj	274	20	,	,	,
cord-321868-xk4yuibj	274	21	usually	usually	RB
cord-321868-xk4yuibj	274	22	the	the	DT
cord-321868-xk4yuibj	274	23	first	first	JJ
cord-321868-xk4yuibj	274	24	AUG	AUG	NNP
cord-321868-xk4yuibj	274	25	codon	codon	NN
cord-321868-xk4yuibj	274	26	in	in	IN
cord-321868-xk4yuibj	274	27	the	the	DT
cord-321868-xk4yuibj	274	28	message	message	NN
cord-321868-xk4yuibj	274	29	.	.	.
cord-321868-xk4yuibj	275	1	The	the	DT
cord-321868-xk4yuibj	275	2	AUG	AUG	NNP
cord-321868-xk4yuibj	275	3	codon	codon	NN
cord-321868-xk4yuibj	275	4	acts	act	VBZ
cord-321868-xk4yuibj	275	5	as	as	IN
cord-321868-xk4yuibj	275	6	a	a	DT
cord-321868-xk4yuibj	275	7	starting	starting	NN
cord-321868-xk4yuibj	275	8	point	point	NN
cord-321868-xk4yuibj	275	9	for	for	IN
cord-321868-xk4yuibj	275	10	translation	translation	NN
cord-321868-xk4yuibj	275	11	and	and	CC
cord-321868-xk4yuibj	275	12	establishes	establish	VBZ
cord-321868-xk4yuibj	275	13	the	the	DT
cord-321868-xk4yuibj	275	14	reading	reading	NN
cord-321868-xk4yuibj	275	15	frame	frame	NN
cord-321868-xk4yuibj	275	16	of	of	IN
cord-321868-xk4yuibj	275	17	the	the	DT
cord-321868-xk4yuibj	275	18	message	message	NN
cord-321868-xk4yuibj	275	19	.	.	.
cord-321868-xk4yuibj	276	1	Disruption	disruption	NN
cord-321868-xk4yuibj	276	2	of	of	IN
cord-321868-xk4yuibj	276	3	the	the	DT
cord-321868-xk4yuibj	276	4	reading	reading	NN
cord-321868-xk4yuibj	276	5	frame	frame	NN
cord-321868-xk4yuibj	276	6	occurs	occur	VBZ
cord-321868-xk4yuibj	276	7	only	only	RB
cord-321868-xk4yuibj	276	8	rarely	rarely	RB
cord-321868-xk4yuibj	276	9	during	during	IN
cord-321868-xk4yuibj	276	10	elongation	elongation	NN
cord-321868-xk4yuibj	276	11	,	,	,
cord-321868-xk4yuibj	276	12	but	but	CC
cord-321868-xk4yuibj	276	13	several	several	JJ
cord-321868-xk4yuibj	276	14	instances	instance	NNS
cord-321868-xk4yuibj	276	15	of	of	IN
cord-321868-xk4yuibj	276	16	reading	read	VBG
cord-321868-xk4yuibj	276	17	frame	frame	NN
cord-321868-xk4yuibj	276	18	shifts	shift	NNS
cord-321868-xk4yuibj	276	19	have	have	VBP
cord-321868-xk4yuibj	276	20	been	be	VBN
cord-321868-xk4yuibj	276	21	observed	observe	VBN
cord-321868-xk4yuibj	276	22	.	.	.
cord-321868-xk4yuibj	277	1	The	the	DT
cord-321868-xk4yuibj	277	2	phages	phage	NNS
cord-321868-xk4yuibj	277	3	f2	f2	NNP
cord-321868-xk4yuibj	277	4	and	and	CC
cord-321868-xk4yuibj	277	5	MS2	MS2	NNP
cord-321868-xk4yuibj	277	6	(	(	-LRB-
cord-321868-xk4yuibj	277	7	Beremand	Beremand	NNP
cord-321868-xk4yuibj	277	8	and	and	CC
cord-321868-xk4yuibj	277	9	Blumenthal	Blumenthal	NNP
cord-321868-xk4yuibj	277	10	,	,	,
cord-321868-xk4yuibj	277	11	1979	1979	CD
cord-321868-xk4yuibj	277	12	;	;	:
cord-321868-xk4yuibj	277	13	Kastelein	Kastelein	NNP
cord-321868-xk4yuibj	277	14	et	et	NNP
cord-321868-xk4yuibj	277	15	al	al	NNP
cord-321868-xk4yuibj	277	16	.	.	NNP
cord-321868-xk4yuibj	277	17	,	,	,
cord-321868-xk4yuibj	277	18	1982	1982	CD
cord-321868-xk4yuibj	277	19	)	)	-RRB-
cord-321868-xk4yuibj	277	20	express	express	VBP
cord-321868-xk4yuibj	277	21	their	-PRON-	PRP$
cord-321868-xk4yuibj	277	22	lysis	lysis	NN
cord-321868-xk4yuibj	277	23	genes	gene	NNS
cord-321868-xk4yuibj	277	24	through	through	IN
cord-321868-xk4yuibj	277	25	a	a	DT
cord-321868-xk4yuibj	277	26	mechanism	mechanism	NN
cord-321868-xk4yuibj	277	27	that	that	WDT
cord-321868-xk4yuibj	277	28	involves	involve	VBZ
cord-321868-xk4yuibj	277	29	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	277	30	within	within	IN
cord-321868-xk4yuibj	277	31	the	the	DT
cord-321868-xk4yuibj	277	32	upstream	upstream	JJ
cord-321868-xk4yuibj	277	33	coat	coat	NN
cord-321868-xk4yuibj	277	34	cistron	cistron	NN
cord-321868-xk4yuibj	277	35	.	.	.
cord-321868-xk4yuibj	278	1	Spontaneous	spontaneous	JJ
cord-321868-xk4yuibj	278	2	readthrough	readthrough	NN
cord-321868-xk4yuibj	278	3	of	of	IN
cord-321868-xk4yuibj	278	4	leaky	leaky	JJ
cord-321868-xk4yuibj	278	5	frameshift	frameshift	NN
cord-321868-xk4yuibj	278	6	mutations	mutation	NNS
cord-321868-xk4yuibj	278	7	occurs	occur	VBZ
cord-321868-xk4yuibj	278	8	within	within	IN
cord-321868-xk4yuibj	278	9	the	the	DT
cord-321868-xk4yuibj	278	10	0x0	0x0	CD
cord-321868-xk4yuibj	278	11	gene	gene	NN
cord-321868-xk4yuibj	278	12	of	of	IN
cord-321868-xk4yuibj	278	13	yeast	yeast	NN
cord-321868-xk4yuibj	278	14	mitochondria	mitochondrion	NNS
cord-321868-xk4yuibj	278	15	(	(	-LRB-
cord-321868-xk4yuibj	278	16	Fox	Fox	NNP
cord-321868-xk4yuibj	278	17	and	and	CC
cord-321868-xk4yuibj	278	18	Weiss	Weiss	NNP
cord-321868-xk4yuibj	278	19	-	-	HYPH
cord-321868-xk4yuibj	278	20	Bummer	Bummer	NNP
cord-321868-xk4yuibj	278	21	,	,	,
cord-321868-xk4yuibj	278	22	1980	1980	CD
cord-321868-xk4yuibj	278	23	)	)	-RRB-
cord-321868-xk4yuibj	278	24	.	.	.
cord-321868-xk4yuibj	279	1	The	the	DT
cord-321868-xk4yuibj	279	2	addition	addition	NN
cord-321868-xk4yuibj	279	3	of	of	IN
cord-321868-xk4yuibj	279	4	a	a	DT
cord-321868-xk4yuibj	279	5	carboxy	carboxy	JJ
cord-321868-xk4yuibj	279	6	-	-	HYPH
cord-321868-xk4yuibj	279	7	terminal	terminal	NN
cord-321868-xk4yuibj	279	8	extension	extension	NN
cord-321868-xk4yuibj	279	9	onto	onto	IN
cord-321868-xk4yuibj	279	10	the	the	DT
cord-321868-xk4yuibj	279	11	phage	phage	NN
cord-321868-xk4yuibj	280	1	T7	T7	NNP
cord-321868-xk4yuibj	280	2	major	major	JJ
cord-321868-xk4yuibj	280	3	coat	coat	NN
cord-321868-xk4yuibj	280	4	protein	protein	NN
cord-321868-xk4yuibj	280	5	also	also	RB
cord-321868-xk4yuibj	280	6	occurs	occur	VBZ
cord-321868-xk4yuibj	280	7	by	by	IN
cord-321868-xk4yuibj	280	8	a	a	DT
cord-321868-xk4yuibj	280	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	280	10	during	during	IN
cord-321868-xk4yuibj	280	11	translation	translation	NN
cord-321868-xk4yuibj	280	12	(	(	-LRB-
cord-321868-xk4yuibj	280	13	Dunn	Dunn	NNP
cord-321868-xk4yuibj	280	14	and	and	CC
cord-321868-xk4yuibj	280	15	Studier	Studier	NNP
cord-321868-xk4yuibj	280	16	,	,	,
cord-321868-xk4yuibj	280	17	1983	1983	CD
cord-321868-xk4yuibj	280	18	)	)	-RRB-
cord-321868-xk4yuibj	280	19	.	.	.
cord-321868-xk4yuibj	281	1	Synthesis	synthesis	NN
cord-321868-xk4yuibj	281	2	of	of	IN
cord-321868-xk4yuibj	281	3	the	the	DT
cord-321868-xk4yuibj	281	4	E.	E.	NNP
cord-321868-xk4yuibj	281	5	coli	coli	NNS
cord-321868-xk4yuibj	281	6	peptide	peptide	NN
cord-321868-xk4yuibj	281	7	release	release	NN
cord-321868-xk4yuibj	281	8	factor	factor	NN
cord-321868-xk4yuibj	281	9	2	2	CD
cord-321868-xk4yuibj	281	10	(	(	-LRB-
cord-321868-xk4yuibj	281	11	RF2	RF2	NNP
cord-321868-xk4yuibj	281	12	)	)	-RRB-
cord-321868-xk4yuibj	281	13	requires	require	VBZ
cord-321868-xk4yuibj	281	14	a	a	DT
cord-321868-xk4yuibj	281	15	+	+	SYM
cord-321868-xk4yuibj	281	16	l	l	NN
cord-321868-xk4yuibj	281	17	frameshift	frameshift	NN
cord-321868-xk4yuibj	281	18	at	at	IN
cord-321868-xk4yuibj	281	19	an	an	DT
cord-321868-xk4yuibj	281	20	in	in	IN
cord-321868-xk4yuibj	281	21	-	-	HYPH
cord-321868-xk4yuibj	281	22	frame	frame	NN
cord-321868-xk4yuibj	281	23	UGA	UGA	NNP
cord-321868-xk4yuibj	281	24	codon	codon	NN
cord-321868-xk4yuibj	281	25	(	(	-LRB-
cord-321868-xk4yuibj	281	26	Craigen	Craigen	NNP
cord-321868-xk4yuibj	281	27	and	and	CC
cord-321868-xk4yuibj	281	28	Caskey	Caskey	NNP
cord-321868-xk4yuibj	281	29	,	,	,
cord-321868-xk4yuibj	281	30	1986	1986	CD
cord-321868-xk4yuibj	281	31	;	;	.
cord-321868-xk4yuibj	282	1	Craigen	Craigen	NNP
cord-321868-xk4yuibj	282	2	et	et	NNP
cord-321868-xk4yuibj	282	3	al	al	NNP
cord-321868-xk4yuibj	282	4	.	.	.
cord-321868-xk4yuibj	283	1	,	,	,
cord-321868-xk4yuibj	283	2	1985	1985	CD
cord-321868-xk4yuibj	283	3	)	)	-RRB-
cord-321868-xk4yuibj	283	4	,	,	,
cord-321868-xk4yuibj	283	5	while	while	IN
cord-321868-xk4yuibj	283	6	some	some	DT
cord-321868-xk4yuibj	283	7	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	283	8	and	and	CC
cord-321868-xk4yuibj	283	9	coronaviruses	coronaviruse	NNS
cord-321868-xk4yuibj	283	10	of	of	IN
cord-321868-xk4yuibj	283	11	higher	high	JJR
cord-321868-xk4yuibj	283	12	eukaryotes	eukaryote	NNS
cord-321868-xk4yuibj	283	13	employ	employ	VBP
cord-321868-xk4yuibj	283	14	a	a	DT
cord-321868-xk4yuibj	283	15	-1	-1	NN
cord-321868-xk4yuibj	283	16	frameshift	frameshift	NN
cord-321868-xk4yuibj	283	17	to	to	TO
cord-321868-xk4yuibj	283	18	express	express	VB
cord-321868-xk4yuibj	283	19	the	the	DT
cord-321868-xk4yuibj	283	20	products	product	NNS
cord-321868-xk4yuibj	283	21	of	of	IN
cord-321868-xk4yuibj	283	22	their	-PRON-	PRP$
cord-321868-xk4yuibj	283	23	pal	pal	NN
cord-321868-xk4yuibj	283	24	(	(	-LRB-
cord-321868-xk4yuibj	283	25	or	or	CC
cord-321868-xk4yuibj	283	26	pro	pro	JJ
cord-321868-xk4yuibj	283	27	)	)	-RRB-
cord-321868-xk4yuibj	283	28	and	and	CC
cord-321868-xk4yuibj	283	29	F2	f2	NN
cord-321868-xk4yuibj	283	30	genes	gene	NNS
cord-321868-xk4yuibj	283	31	,	,	,
cord-321868-xk4yuibj	283	32	respectively	respectively	RB
cord-321868-xk4yuibj	283	33	(	(	-LRB-
cord-321868-xk4yuibj	283	34	Brierley	Brierley	NNP
cord-321868-xk4yuibj	283	35	et	et	NNP
cord-321868-xk4yuibj	283	36	al	al	NNP
cord-321868-xk4yuibj	283	37	.	.	NNP
cord-321868-xk4yuibj	283	38	,	,	,
cord-321868-xk4yuibj	283	39	1987	1987	CD
cord-321868-xk4yuibj	283	40	(	(	-LRB-
cord-321868-xk4yuibj	283	41	Brierley	Brierley	NNP
cord-321868-xk4yuibj	283	42	et	et	NNP
cord-321868-xk4yuibj	283	43	al	al	NNP
cord-321868-xk4yuibj	283	44	.	.	NNP
cord-321868-xk4yuibj	283	45	,	,	,
cord-321868-xk4yuibj	283	46	,	,	,
cord-321868-xk4yuibj	283	47	1989	1989	CD
cord-321868-xk4yuibj	283	48	Jacks	Jacks	NNPS
cord-321868-xk4yuibj	283	49	et	et	NNP
cord-321868-xk4yuibj	283	50	al	al	NNP
cord-321868-xk4yuibj	283	51	.	.	NNP
cord-321868-xk4yuibj	283	52	,	,	,
cord-321868-xk4yuibj	284	1	1987	1987	CD
cord-321868-xk4yuibj	284	2	Jacks	Jacks	NNPS
cord-321868-xk4yuibj	284	3	et	et	NNP
cord-321868-xk4yuibj	284	4	al	al	NNP
cord-321868-xk4yuibj	284	5	.	.	.
cord-321868-xk4yuibj	285	1	,	,	,
cord-321868-xk4yuibj	285	2	,	,	,
cord-321868-xk4yuibj	285	3	1988a	1988a	CD
cord-321868-xk4yuibj	285	4	Jacks	Jacks	NNP
cord-321868-xk4yuibj	285	5	et	et	NNP
cord-321868-xk4yuibj	285	6	al	al	NNP
cord-321868-xk4yuibj	285	7	.	.	.
cord-321868-xk4yuibj	286	1	,	,	,
cord-321868-xk4yuibj	286	2	,	,	,
cord-321868-xk4yuibj	286	3	1988b	1988b	CD
cord-321868-xk4yuibj	286	4	Jacks	Jacks	NNPS
cord-321868-xk4yuibj	286	5	and	and	CC
cord-321868-xk4yuibj	286	6	Varmus	Varmus	NNP
cord-321868-xk4yuibj	286	7	,	,	,
cord-321868-xk4yuibj	286	8	1985	1985	CD
cord-321868-xk4yuibj	286	9	;	;	:
cord-321868-xk4yuibj	286	10	Wilson	Wilson	NNP
cord-321868-xk4yuibj	286	11	et	et	NNP
cord-321868-xk4yuibj	286	12	al	al	NNP
cord-321868-xk4yuibj	286	13	.	.	NNP
cord-321868-xk4yuibj	286	14	,	,	,
cord-321868-xk4yuibj	286	15	1988	1988	CD
cord-321868-xk4yuibj	286	16	)	)	-RRB-
cord-321868-xk4yuibj	286	17	.	.	.
cord-321868-xk4yuibj	287	1	Frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	287	2	in	in	IN
cord-321868-xk4yuibj	287	3	the	the	DT
cord-321868-xk4yuibj	287	4	two	two	CD
cord-321868-xk4yuibj	287	5	best	well	RBS
cord-321868-xk4yuibj	287	6	-	-	HYPH
cord-321868-xk4yuibj	287	7	studied	study	VBN
cord-321868-xk4yuibj	287	8	systems	system	NNS
cord-321868-xk4yuibj	287	9	,	,	,
cord-321868-xk4yuibj	287	10	the	the	DT
cord-321868-xk4yuibj	287	11	RF2	RF2	NNP
cord-321868-xk4yuibj	287	12	gene	gene	NN
cord-321868-xk4yuibj	287	13	of	of	IN
cord-321868-xk4yuibj	287	14	E.	E.	NNP
cord-321868-xk4yuibj	287	15	coli	coli	NNS
cord-321868-xk4yuibj	287	16	and	and	CC
cord-321868-xk4yuibj	287	17	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	287	18	of	of	IN
cord-321868-xk4yuibj	287	19	higher	high	JJR
cord-321868-xk4yuibj	287	20	eukaryotes	eukaryote	NNS
cord-321868-xk4yuibj	287	21	,	,	,
cord-321868-xk4yuibj	287	22	have	have	VBP
cord-321868-xk4yuibj	287	23	several	several	JJ
cord-321868-xk4yuibj	287	24	unifying	unifying	JJ
cord-321868-xk4yuibj	287	25	features	feature	NNS
cord-321868-xk4yuibj	287	26	.	.	.
cord-321868-xk4yuibj	288	1	Codon	Codon	NNP
cord-321868-xk4yuibj	288	2	26	26	CD
cord-321868-xk4yuibj	288	3	of	of	IN
cord-321868-xk4yuibj	288	4	the	the	DT
cord-321868-xk4yuibj	288	5	RF2	RF2	NNP
cord-321868-xk4yuibj	288	6	gene	gene	NN
cord-321868-xk4yuibj	288	7	of	of	IN
cord-321868-xk4yuibj	288	8	E.	E.	NNP
cord-321868-xk4yuibj	288	9	coli	coli	NNS
cord-321868-xk4yuibj	288	10	is	be	VBZ
cord-321868-xk4yuibj	288	11	an	an	DT
cord-321868-xk4yuibj	288	12	in	in	IN
cord-321868-xk4yuibj	288	13	-	-	HYPH
cord-321868-xk4yuibj	288	14	frame	frame	NN
cord-321868-xk4yuibj	288	15	UGA	UGA	NNP
cord-321868-xk4yuibj	288	16	termination	termination	NN
cord-321868-xk4yuibj	288	17	codon	codon	NN
cord-321868-xk4yuibj	288	18	,	,	,
cord-321868-xk4yuibj	288	19	one	one	CD
cord-321868-xk4yuibj	288	20	of	of	IN
cord-321868-xk4yuibj	288	21	two	two	CD
cord-321868-xk4yuibj	288	22	codons	codon	NNS
cord-321868-xk4yuibj	288	23	recognized	recognize	VBN
cord-321868-xk4yuibj	288	24	by	by	IN
cord-321868-xk4yuibj	288	25	RF2	RF2	NNP
cord-321868-xk4yuibj	288	26	(	(	-LRB-
cord-321868-xk4yuibj	288	27	Scolnick	Scolnick	NNP
cord-321868-xk4yuibj	288	28	and	and	CC
cord-321868-xk4yuibj	288	29	Caskey	Caskey	NNP
cord-321868-xk4yuibj	288	30	,	,	,
cord-321868-xk4yuibj	288	31	1969	1969	CD
cord-321868-xk4yuibj	288	32	)	)	-RRB-
cord-321868-xk4yuibj	288	33	.	.	.
cord-321868-xk4yuibj	289	1	The	the	DT
cord-321868-xk4yuibj	289	2	UGA	UGA	NNP
cord-321868-xk4yuibj	289	3	codon	codon	NN
cord-321868-xk4yuibj	289	4	is	be	VBZ
cord-321868-xk4yuibj	289	5	probably	probably	RB
cord-321868-xk4yuibj	289	6	the	the	DT
cord-321868-xk4yuibj	289	7	site	site	NN
cord-321868-xk4yuibj	289	8	of	of	IN
cord-321868-xk4yuibj	289	9	an	an	DT
cord-321868-xk4yuibj	289	10	autogenous	autogenous	JJ
cord-321868-xk4yuibj	289	11	control	control	NN
cord-321868-xk4yuibj	289	12	system	system	NN
cord-321868-xk4yuibj	289	13	.	.	.
cord-321868-xk4yuibj	290	1	Instead	instead	RB
cord-321868-xk4yuibj	290	2	of	of	IN
cord-321868-xk4yuibj	290	3	prematurely	prematurely	RB
cord-321868-xk4yuibj	290	4	terminating	terminate	VBG
cord-321868-xk4yuibj	290	5	at	at	IN
cord-321868-xk4yuibj	290	6	the	the	DT
cord-321868-xk4yuibj	290	7	UGA	UGA	NNP
cord-321868-xk4yuibj	290	8	codon	codon	NN
cord-321868-xk4yuibj	290	9	,	,	,
cord-321868-xk4yuibj	290	10	50	50	CD
cord-321868-xk4yuibj	290	11	%	%	NN
cord-321868-xk4yuibj	290	12	of	of	IN
cord-321868-xk4yuibj	290	13	the	the	DT
cord-321868-xk4yuibj	290	14	ribosomes	ribosome	NNS
cord-321868-xk4yuibj	290	15	shift	shift	VBP
cord-321868-xk4yuibj	290	16	into	into	IN
cord-321868-xk4yuibj	290	17	the	the	DT
cord-321868-xk4yuibj	290	18	+	+	NN
cord-321868-xk4yuibj	290	19	l	l	NN
cord-321868-xk4yuibj	290	20	frame	frame	NN
cord-321868-xk4yuibj	290	21	at	at	IN
cord-321868-xk4yuibj	290	22	the	the	DT
cord-321868-xk4yuibj	290	23	position	position	NN
cord-321868-xk4yuibj	290	24	of	of	IN
cord-321868-xk4yuibj	290	25	the	the	DT
cord-321868-xk4yuibj	290	26	CUU	CUU	NNP
cord-321868-xk4yuibj	290	27	(	(	-LRB-
cord-321868-xk4yuibj	290	28	Leu	Leu	NNP
cord-321868-xk4yuibj	290	29	)	)	-RRB-
cord-321868-xk4yuibj	290	30	codon	codon	NN
cord-321868-xk4yuibj	290	31	immediately	immediately	RB
cord-321868-xk4yuibj	290	32	preceding	precede	VBG
cord-321868-xk4yuibj	290	33	the	the	DT
cord-321868-xk4yuibj	290	34	UGA	UGA	NNP
cord-321868-xk4yuibj	290	35	(	(	-LRB-
cord-321868-xk4yuibj	290	36	Craigen	Craigen	NNP
cord-321868-xk4yuibj	290	37	and	and	CC
cord-321868-xk4yuibj	290	38	Caskey	Caskey	NNP
cord-321868-xk4yuibj	290	39	,	,	,
cord-321868-xk4yuibj	290	40	1986	1986	CD
cord-321868-xk4yuibj	290	41	;	;	.
cord-321868-xk4yuibj	291	1	Craigen	Craigen	NNP
cord-321868-xk4yuibj	291	2	et	et	NNP
cord-321868-xk4yuibj	291	3	al	al	NNP
cord-321868-xk4yuibj	291	4	.	.	NNP
cord-321868-xk4yuibj	291	5	,	,	,
cord-321868-xk4yuibj	291	6	1985	1985	CD
cord-321868-xk4yuibj	291	7	)	)	-RRB-
cord-321868-xk4yuibj	291	8	.	.	.
cord-321868-xk4yuibj	292	1	In	in	IN
cord-321868-xk4yuibj	292	2	an	an	DT
cord-321868-xk4yuibj	292	3	exhaustive	exhaustive	JJ
cord-321868-xk4yuibj	292	4	study	study	NN
cord-321868-xk4yuibj	292	5	,	,	,
cord-321868-xk4yuibj	292	6	Weiss	Weiss	NNP
cord-321868-xk4yuibj	292	7	et	et	NNP
cord-321868-xk4yuibj	292	8	al	al	NNP
cord-321868-xk4yuibj	292	9	.	.	.
cord-321868-xk4yuibj	293	1	(	(	-LRB-
cord-321868-xk4yuibj	293	2	1987	1987	CD
cord-321868-xk4yuibj	293	3	have	have	VBP
cord-321868-xk4yuibj	293	4	defined	define	VBN
cord-321868-xk4yuibj	293	5	the	the	DT
cord-321868-xk4yuibj	293	6	minimal	minimal	JJ
cord-321868-xk4yuibj	293	7	requirements	requirement	NNS
cord-321868-xk4yuibj	293	8	of	of	IN
cord-321868-xk4yuibj	293	9	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	293	10	in	in	IN
cord-321868-xk4yuibj	293	11	E.	E.	NNP
cord-321868-xk4yuibj	293	12	coli	coli	NNS
cord-321868-xk4yuibj	293	13	.	.	.
cord-321868-xk4yuibj	294	1	They	-PRON-	PRP
cord-321868-xk4yuibj	294	2	find	find	VBP
cord-321868-xk4yuibj	294	3	that	that	IN
cord-321868-xk4yuibj	294	4	the	the	DT
cord-321868-xk4yuibj	294	5	three	three	CD
cord-321868-xk4yuibj	294	6	things	thing	NNS
cord-321868-xk4yuibj	294	7	necessary	necessary	JJ
cord-321868-xk4yuibj	294	8	for	for	IN
cord-321868-xk4yuibj	294	9	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	294	10	to	to	TO
cord-321868-xk4yuibj	294	11	occur	occur	VB
cord-321868-xk4yuibj	294	12	are	be	VBP
cord-321868-xk4yuibj	294	13	a	a	DT
cord-321868-xk4yuibj	294	14	"	"	``
cord-321868-xk4yuibj	294	15	slippery	slippery	JJ
cord-321868-xk4yuibj	294	16	run:'or	run:'or	JJ
cord-321868-xk4yuibj	294	17	repeat	repeat	NN
cord-321868-xk4yuibj	294	18	of	of	IN
cord-321868-xk4yuibj	294	19	several	several	JJ
cord-321868-xk4yuibj	294	20	identical	identical	JJ
cord-321868-xk4yuibj	294	21	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	294	22	in	in	IN
cord-321868-xk4yuibj	294	23	the	the	DT
cord-321868-xk4yuibj	294	24	RNA	RNA	NNP
cord-321868-xk4yuibj	294	25	,	,	,
cord-321868-xk4yuibj	294	26	followed	follow	VBD
cord-321868-xk4yuibj	294	27	immediately	immediately	RB
cord-321868-xk4yuibj	294	28	by	by	IN
cord-321868-xk4yuibj	294	29	a	a	DT
cord-321868-xk4yuibj	294	30	termination	termination	NN
cord-321868-xk4yuibj	294	31	codon	codon	NN
cord-321868-xk4yuibj	294	32	and	and	CC
cord-321868-xk4yuibj	294	33	preceded	precede	VBN
cord-321868-xk4yuibj	294	34	by	by	IN
cord-321868-xk4yuibj	294	35	a	a	DT
cord-321868-xk4yuibj	294	36	Shine	Shine	NNP
cord-321868-xk4yuibj	294	37	-	-	HYPH
cord-321868-xk4yuibj	294	38	Dalgarno	Dalgarno	NNP
cord-321868-xk4yuibj	294	39	sequence	sequence	NN
cord-321868-xk4yuibj	294	40	(	(	-LRB-
cord-321868-xk4yuibj	294	41	Shine	Shine	NNP
cord-321868-xk4yuibj	294	42	and	and	CC
cord-321868-xk4yuibj	294	43	Dalgarno	Dalgarno	NNP
cord-321868-xk4yuibj	294	44	,	,	,
cord-321868-xk4yuibj	294	45	1974	1974	CD
cord-321868-xk4yuibj	294	46	)	)	-RRB-
cord-321868-xk4yuibj	294	47	a	a	DT
cord-321868-xk4yuibj	294	48	precise	precise	JJ
cord-321868-xk4yuibj	294	49	distance	distance	NN
cord-321868-xk4yuibj	294	50	away	away	RB
cord-321868-xk4yuibj	294	51	.	.	.
cord-321868-xk4yuibj	295	1	Constructs	construct	NNS
cord-321868-xk4yuibj	295	2	were	be	VBD
cord-321868-xk4yuibj	295	3	made	make	VBN
cord-321868-xk4yuibj	295	4	that	that	IN
cord-321868-xk4yuibj	295	5	frameshifted	frameshifte	VBN
cord-321868-xk4yuibj	295	6	-2	-2	NNP
cord-321868-xk4yuibj	295	7	,	,	,
cord-321868-xk4yuibj	295	8	-1	-1	NNP
cord-321868-xk4yuibj	295	9	,	,	,
cord-321868-xk4yuibj	295	10	+	+	CC
cord-321868-xk4yuibj	296	1	l	l	NNP
cord-321868-xk4yuibj	296	2	,	,	,
cord-321868-xk4yuibj	296	3	+2	+2	NNP
cord-321868-xk4yuibj	296	4	,	,	,
cord-321868-xk4yuibj	296	5	+5	+5	NNP
cord-321868-xk4yuibj	296	6	,	,	,
cord-321868-xk4yuibj	296	7	and	and	CC
cord-321868-xk4yuibj	296	8	+6	+6	LS
cord-321868-xk4yuibj	296	9	with	with	IN
cord-321868-xk4yuibj	296	10	varying	vary	VBG
cord-321868-xk4yuibj	296	11	efficiency	efficiency	NN
cord-321868-xk4yuibj	296	12	.	.	.
cord-321868-xk4yuibj	297	1	The	the	DT
cord-321868-xk4yuibj	297	2	proposed	propose	VBN
cord-321868-xk4yuibj	297	3	mechanism	mechanism	NN
cord-321868-xk4yuibj	297	4	involves	involve	VBZ
cord-321868-xk4yuibj	297	5	binding	binding	NN
cord-321868-xk4yuibj	297	6	of	of	IN
cord-321868-xk4yuibj	297	7	a	a	DT
cord-321868-xk4yuibj	297	8	tRNA	trna	NN
cord-321868-xk4yuibj	297	9	in	in	IN
cord-321868-xk4yuibj	297	10	the	the	DT
cord-321868-xk4yuibj	297	11	"	"	``
cord-321868-xk4yuibj	297	12	slippery	slippery	JJ
cord-321868-xk4yuibj	297	13	run	run	NN
cord-321868-xk4yuibj	297	14	.	.	.
cord-321868-xk4yuibj	297	15	"	"	''
cord-321868-xk4yuibj	298	1	A	a	DT
cord-321868-xk4yuibj	298	2	translational	translational	JJ
cord-321868-xk4yuibj	298	3	pause	pause	NN
cord-321868-xk4yuibj	298	4	,	,	,
cord-321868-xk4yuibj	298	5	induced	induce	VBN
cord-321868-xk4yuibj	298	6	by	by	IN
cord-321868-xk4yuibj	298	7	the	the	DT
cord-321868-xk4yuibj	298	8	slow	slow	JJ
cord-321868-xk4yuibj	298	9	process	process	NN
cord-321868-xk4yuibj	298	10	of	of	IN
cord-321868-xk4yuibj	298	11	termination	termination	NN
cord-321868-xk4yuibj	298	12	at	at	IN
cord-321868-xk4yuibj	298	13	the	the	DT
cord-321868-xk4yuibj	298	14	nonsense	nonsense	NN
cord-321868-xk4yuibj	298	15	codon	codon	NN
cord-321868-xk4yuibj	298	16	,	,	,
cord-321868-xk4yuibj	298	17	allows	allow	VBZ
cord-321868-xk4yuibj	298	18	an	an	DT
cord-321868-xk4yuibj	298	19	interaction	interaction	NN
cord-321868-xk4yuibj	298	20	between	between	IN
cord-321868-xk4yuibj	298	21	the	the	DT
cord-321868-xk4yuibj	298	22	Shine	Shine	NNP
cord-321868-xk4yuibj	298	23	-	-	HYPH
cord-321868-xk4yuibj	298	24	Dalgarno	Dalgarno	NNP
cord-321868-xk4yuibj	298	25	-	-	HYPH
cord-321868-xk4yuibj	298	26	like	like	JJ
cord-321868-xk4yuibj	298	27	sequence	sequence	NN
cord-321868-xk4yuibj	298	28	upstream	upstream	RB
cord-321868-xk4yuibj	298	29	of	of	IN
cord-321868-xk4yuibj	298	30	the	the	DT
cord-321868-xk4yuibj	298	31	frameshift	frameshift	NN
cord-321868-xk4yuibj	298	32	site	site	NN
cord-321868-xk4yuibj	298	33	and	and	CC
cord-321868-xk4yuibj	298	34	the	the	DT
cord-321868-xk4yuibj	298	35	16s	16s	NNPS
cord-321868-xk4yuibj	298	36	RNA	RNA	NNP
cord-321868-xk4yuibj	298	37	.	.	.
cord-321868-xk4yuibj	299	1	The	the	DT
cord-321868-xk4yuibj	299	2	interaction	interaction	NN
cord-321868-xk4yuibj	299	3	"	"	``
cord-321868-xk4yuibj	299	4	pulls	pull	VBZ
cord-321868-xk4yuibj	299	5	"	"	''
cord-321868-xk4yuibj	299	6	or	or	CC
cord-321868-xk4yuibj	299	7	"	"	``
cord-321868-xk4yuibj	299	8	pushes	push	VBZ
cord-321868-xk4yuibj	299	9	"	"	''
cord-321868-xk4yuibj	299	10	the	the	DT
cord-321868-xk4yuibj	299	11	ribosome	ribosome	NN
cord-321868-xk4yuibj	299	12	,	,	,
cord-321868-xk4yuibj	299	13	causing	cause	VBG
cord-321868-xk4yuibj	299	14	the	the	DT
cord-321868-xk4yuibj	299	15	tRNA	trna	NN
cord-321868-xk4yuibj	299	16	to	to	TO
cord-321868-xk4yuibj	299	17	slip	slip	VB
cord-321868-xk4yuibj	299	18	along	along	IN
cord-321868-xk4yuibj	299	19	the	the	DT
cord-321868-xk4yuibj	299	20	slippery	slippery	JJ
cord-321868-xk4yuibj	299	21	run	run	NN
cord-321868-xk4yuibj	299	22	.	.	.
cord-321868-xk4yuibj	300	1	Translation	translation	NN
cord-321868-xk4yuibj	300	2	then	then	RB
cord-321868-xk4yuibj	300	3	continues	continue	VBZ
cord-321868-xk4yuibj	300	4	in	in	IN
cord-321868-xk4yuibj	300	5	the	the	DT
cord-321868-xk4yuibj	300	6	new	new	JJ
cord-321868-xk4yuibj	300	7	frame	frame	NN
cord-321868-xk4yuibj	300	8	.	.	.
cord-321868-xk4yuibj	301	1	The	the	DT
cord-321868-xk4yuibj	301	2	mechanism	mechanism	NN
cord-321868-xk4yuibj	301	3	of	of	IN
cord-321868-xk4yuibj	301	4	-1	-1	NN
cord-321868-xk4yuibj	301	5	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	301	6	in	in	IN
cord-321868-xk4yuibj	301	7	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	301	8	has	have	VBZ
cord-321868-xk4yuibj	301	9	been	be	VBN
cord-321868-xk4yuibj	301	10	shown	show	VBN
cord-321868-xk4yuibj	301	11	to	to	TO
cord-321868-xk4yuibj	301	12	involve	involve	VB
cord-321868-xk4yuibj	301	13	both	both	CC
cord-321868-xk4yuibj	301	14	a	a	DT
cord-321868-xk4yuibj	301	15	specific	specific	JJ
cord-321868-xk4yuibj	301	16	"	"	``
cord-321868-xk4yuibj	301	17	slippery	slippery	JJ
cord-321868-xk4yuibj	301	18	"	"	''
cord-321868-xk4yuibj	301	19	sequence	sequence	NN
cord-321868-xk4yuibj	301	20	and	and	CC
cord-321868-xk4yuibj	301	21	,	,	,
cord-321868-xk4yuibj	301	22	in	in	IN
cord-321868-xk4yuibj	301	23	some	some	DT
cord-321868-xk4yuibj	301	24	cases	case	NNS
cord-321868-xk4yuibj	301	25	,	,	,
cord-321868-xk4yuibj	301	26	a	a	DT
cord-321868-xk4yuibj	301	27	conserved	conserved	JJ
cord-321868-xk4yuibj	301	28	secondary	secondary	JJ
cord-321868-xk4yuibj	301	29	structure	structure	NN
cord-321868-xk4yuibj	301	30	.	.	.
cord-321868-xk4yuibj	302	1	Jacks	Jacks	NNP
cord-321868-xk4yuibj	302	2	et	et	NNP
cord-321868-xk4yuibj	302	3	al	al	NNP
cord-321868-xk4yuibj	302	4	.	.	.
cord-321868-xk4yuibj	303	1	(	(	-LRB-
cord-321868-xk4yuibj	303	2	1988a	1988a	CD
cord-321868-xk4yuibj	303	3	)	)	-RRB-
cord-321868-xk4yuibj	303	4	showed	show	VBD
cord-321868-xk4yuibj	303	5	that	that	IN
cord-321868-xk4yuibj	303	6	three	three	CD
cord-321868-xk4yuibj	303	7	subsets	subset	NNS
cord-321868-xk4yuibj	303	8	of	of	IN
cord-321868-xk4yuibj	303	9	repetitive	repetitive	JJ
cord-321868-xk4yuibj	303	10	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	303	11	conserved	conserve	VBN
cord-321868-xk4yuibj	303	12	among	among	IN
cord-321868-xk4yuibj	303	13	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	303	14	constitute	constitute	VBP
cord-321868-xk4yuibj	303	15	the	the	DT
cord-321868-xk4yuibj	303	16	sites	site	NNS
cord-321868-xk4yuibj	303	17	of	of	IN
cord-321868-xk4yuibj	303	18	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	303	19	.	.	.
cord-321868-xk4yuibj	304	1	Protein	protein	NN
cord-321868-xk4yuibj	304	2	sequence	sequence	NN
cord-321868-xk4yuibj	304	3	analysis	analysis	NN
cord-321868-xk4yuibj	304	4	and	and	CC
cord-321868-xk4yuibj	304	5	sitedirected	sitedirected	JJ
cord-321868-xk4yuibj	304	6	mutagenesis	mutagenesis	NN
cord-321868-xk4yuibj	304	7	of	of	IN
cord-321868-xk4yuibj	304	8	the	the	DT
cord-321868-xk4yuibj	304	9	gag	gag	NN
cord-321868-xk4yuibj	304	10	-	-	HYPH
cord-321868-xk4yuibj	304	11	pro	pro	JJ
cord-321868-xk4yuibj	304	12	fusion	fusion	NN
cord-321868-xk4yuibj	304	13	junction	junction	NN
cord-321868-xk4yuibj	304	14	from	from	IN
cord-321868-xk4yuibj	304	15	MMTV	MMTV	NNP
cord-321868-xk4yuibj	305	1	(	(	-LRB-
cord-321868-xk4yuibj	305	2	Jacks	Jacks	NNP
cord-321868-xk4yuibj	305	3	et	et	NNP
cord-321868-xk4yuibj	305	4	al	al	NNP
cord-321868-xk4yuibj	305	5	.	.	NNP
cord-321868-xk4yuibj	305	6	,	,	,
cord-321868-xk4yuibj	305	7	1987	1987	CD
cord-321868-xk4yuibj	305	8	)	)	-RRB-
cord-321868-xk4yuibj	306	1	HIV-1	HIV-1	NNP
cord-321868-xk4yuibj	307	1	(	(	-LRB-
cord-321868-xk4yuibj	307	2	Jacks	Jacks	NNP
cord-321868-xk4yuibj	307	3	et	et	NNP
cord-321868-xk4yuibj	307	4	al	al	NNP
cord-321868-xk4yuibj	307	5	.	.	.
cord-321868-xk4yuibj	308	1	,	,	,
cord-321868-xk4yuibj	308	2	1988b	1988b	CD
cord-321868-xk4yuibj	308	3	Wilson	Wilson	NNP
cord-321868-xk4yuibj	308	4	et	et	NNP
cord-321868-xk4yuibj	308	5	al	al	NNP
cord-321868-xk4yuibj	308	6	.	.	NNP
cord-321868-xk4yuibj	308	7	,	,	,
cord-321868-xk4yuibj	308	8	1988	1988	CD
cord-321868-xk4yuibj	308	9	)	)	-RRB-
cord-321868-xk4yuibj	308	10	and	and	CC
cord-321868-xk4yuibj	308	11	RSV	RSV	NNP
cord-321868-xk4yuibj	308	12	(	(	-LRB-
cord-321868-xk4yuibj	308	13	Jacks	Jacks	NNP
cord-321868-xk4yuibj	308	14	et	et	NNP
cord-321868-xk4yuibj	308	15	al	al	NNP
cord-321868-xk4yuibj	308	16	.	.	NNP
cord-321868-xk4yuibj	308	17	,	,	,
cord-321868-xk4yuibj	308	18	1988a	1988a	CD
cord-321868-xk4yuibj	308	19	)	)	-RRB-
cord-321868-xk4yuibj	308	20	demonstrated	demonstrate	VBD
cord-321868-xk4yuibj	308	21	that	that	IN
cord-321868-xk4yuibj	308	22	the	the	DT
cord-321868-xk4yuibj	308	23	event	event	NN
cord-321868-xk4yuibj	308	24	occurs	occur	VBZ
cord-321868-xk4yuibj	308	25	at	at	IN
cord-321868-xk4yuibj	308	26	these	these	DT
cord-321868-xk4yuibj	308	27	repetitive	repetitive	JJ
cord-321868-xk4yuibj	308	28	sequences	sequence	NNS
cord-321868-xk4yuibj	308	29	:	:	:
cord-321868-xk4yuibj	308	30	in	in	IN
cord-321868-xk4yuibj	308	31	MMTV	MMTV	NNS
cord-321868-xk4yuibj	308	32	at	at	IN
cord-321868-xk4yuibj	308	33	the	the	DT
cord-321868-xk4yuibj	308	34	sequence	sequence	NN
cord-321868-xk4yuibj	309	1	A	a	LS
cord-321868-xk4yuibj	309	2	-	-	HYPH
cord-321868-xk4yuibj	309	3	AAA	aaa	NN
cord-321868-xk4yuibj	309	4	-	-	HYPH
cord-321868-xk4yuibj	309	5	AAC	aac	NN
cord-321868-xk4yuibj	310	1	(	(	-LRB-
cord-321868-xk4yuibj	310	2	shown	show	VBN
cord-321868-xk4yuibj	310	3	as	as	IN
cord-321868-xk4yuibj	310	4	gag	gag	NN
cord-321868-xk4yuibj	310	5	frame	frame	NN
cord-321868-xk4yuibj	310	6	codons	codon	NNS
cord-321868-xk4yuibj	310	7	)	)	-RRB-
cord-321868-xk4yuibj	310	8	,	,	,
cord-321868-xk4yuibj	310	9	in	in	IN
cord-321868-xk4yuibj	310	10	HIV	HIV	NNP
cord-321868-xk4yuibj	310	11	-	-	HYPH
cord-321868-xk4yuibj	310	12	l	l	NNP
cord-321868-xk4yuibj	310	13	at	at	IN
cord-321868-xk4yuibj	310	14	the	the	DT
cord-321868-xk4yuibj	310	15	sequence	sequence	NN
cord-321868-xk4yuibj	310	16	U	U	NNP
cord-321868-xk4yuibj	310	17	-	-	HYPH
cord-321868-xk4yuibj	310	18	UUU	UUU	NNP
cord-321868-xk4yuibj	310	19	-	-	HYPH
cord-321868-xk4yuibj	310	20	UUA	UUA	NNP
cord-321868-xk4yuibj	310	21	,	,	,
cord-321868-xk4yuibj	310	22	and	and	CC
cord-321868-xk4yuibj	310	23	in	in	IN
cord-321868-xk4yuibj	310	24	RSV	RSV	NNP
cord-321868-xk4yuibj	310	25	at	at	IN
cord-321868-xk4yuibj	310	26	the	the	DT
cord-321868-xk4yuibj	310	27	sequence	sequence	NN
cord-321868-xk4yuibj	310	28	A	A	NNP
cord-321868-xk4yuibj	310	29	-	-	HYPH
cord-321868-xk4yuibj	310	30	AAU	AAU	NNP
cord-321868-xk4yuibj	310	31	-	-	HYPH
cord-321868-xk4yuibj	310	32	UUA	UUA	NNP
cord-321868-xk4yuibj	310	33	.	.	.
cord-321868-xk4yuibj	311	1	Similar	similar	JJ
cord-321868-xk4yuibj	311	2	sequences	sequence	NNS
cord-321868-xk4yuibj	311	3	from	from	IN
cord-321868-xk4yuibj	311	4	IBV	IBV	NNP
cord-321868-xk4yuibj	311	5	,	,	,
cord-321868-xk4yuibj	311	6	BLV	BLV	NNP
cord-321868-xk4yuibj	311	7	,	,	,
cord-321868-xk4yuibj	311	8	and	and	CC
cord-321868-xk4yuibj	311	9	SRV-1	SRV-1	NNP
cord-321868-xk4yuibj	311	10	can	can	MD
cord-321868-xk4yuibj	311	11	also	also	RB
cord-321868-xk4yuibj	311	12	support	support	VB
cord-321868-xk4yuibj	311	13	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	311	14	(	(	-LRB-
cord-321868-xk4yuibj	311	15	Jacks	Jacks	NNP
cord-321868-xk4yuibj	311	16	et	et	NNP
cord-321868-xk4yuibj	311	17	al	al	NNP
cord-321868-xk4yuibj	311	18	.	.	NNP
cord-321868-xk4yuibj	311	19	,	,	,
cord-321868-xk4yuibj	311	20	1988a	1988a	CD
cord-321868-xk4yuibj	311	21	)	)	-RRB-
cord-321868-xk4yuibj	311	22	.	.	.
cord-321868-xk4yuibj	312	1	Most	Most	JJS
cord-321868-xk4yuibj	312	2	retrovirus	retrovirus	NN
cord-321868-xk4yuibj	312	3	frameshift	frameshift	NN
cord-321868-xk4yuibj	312	4	events	event	NNS
cord-321868-xk4yuibj	312	5	also	also	RB
cord-321868-xk4yuibj	312	6	require	require	VBP
cord-321868-xk4yuibj	312	7	a	a	DT
cord-321868-xk4yuibj	312	8	conserved	conserved	JJ
cord-321868-xk4yuibj	312	9	pseudoknot	pseudoknot	NN
cord-321868-xk4yuibj	312	10	structure	structure	NN
cord-321868-xk4yuibj	312	11	located	locate	VBN
cord-321868-xk4yuibj	312	12	immediately	immediately	RB
cord-321868-xk4yuibj	312	13	downstream	downstream	RB
cord-321868-xk4yuibj	312	14	of	of	IN
cord-321868-xk4yuibj	312	15	all	all	DT
cord-321868-xk4yuibj	312	16	retroviral	retroviral	NN
cord-321868-xk4yuibj	312	17	frameshift	frameshift	NN
cord-321868-xk4yuibj	312	18	sites	site	NNS
cord-321868-xk4yuibj	312	19	(	(	-LRB-
cord-321868-xk4yuibj	313	1	Jacks	Jacks	NNP
cord-321868-xk4yuibj	313	2	et	et	NNP
cord-321868-xk4yuibj	313	3	al	al	NNP
cord-321868-xk4yuibj	313	4	.	.	.
cord-321868-xk4yuibj	314	1	,	,	,
cord-321868-xk4yuibj	314	2	1988a	1988a	CD
cord-321868-xk4yuibj	314	3	)	)	-RRB-
cord-321868-xk4yuibj	314	4	,	,	,
cord-321868-xk4yuibj	314	5	a	a	DT
cord-321868-xk4yuibj	314	6	requirement	requirement	NN
cord-321868-xk4yuibj	314	7	also	also	RB
cord-321868-xk4yuibj	314	8	seen	see	VBN
cord-321868-xk4yuibj	314	9	in	in	IN
cord-321868-xk4yuibj	314	10	IBV	IBV	NNP
cord-321868-xk4yuibj	314	11	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	315	1	(	(	-LRB-
cord-321868-xk4yuibj	315	2	Brierley	Brierley	NNP
cord-321868-xk4yuibj	315	3	et	et	NNP
cord-321868-xk4yuibj	315	4	al	al	NNP
cord-321868-xk4yuibj	315	5	.	.	NNP
cord-321868-xk4yuibj	315	6	,	,	,
cord-321868-xk4yuibj	315	7	1989	1989	CD
cord-321868-xk4yuibj	315	8	)	)	-RRB-
cord-321868-xk4yuibj	315	9	.	.	.
cord-321868-xk4yuibj	316	1	Notably	notably	RB
cord-321868-xk4yuibj	316	2	,	,	,
cord-321868-xk4yuibj	316	3	HIV-1	HIV-1	NNP
cord-321868-xk4yuibj	316	4	does	do	VBZ
cord-321868-xk4yuibj	316	5	not	not	RB
cord-321868-xk4yuibj	316	6	require	require	VB
cord-321868-xk4yuibj	316	7	its	-PRON-	PRP$
cord-321868-xk4yuibj	316	8	pseudoknot	pseudoknot	NN
cord-321868-xk4yuibj	316	9	structure	structure	NN
cord-321868-xk4yuibj	316	10	for	for	IN
cord-321868-xk4yuibj	316	11	frameshifting	frameshifting	NNP
cord-321868-xk4yuibj	317	1	(	(	-LRB-
cord-321868-xk4yuibj	317	2	Jacks	Jacks	NNP
cord-321868-xk4yuibj	317	3	et	et	NNP
cord-321868-xk4yuibj	317	4	al	al	NNP
cord-321868-xk4yuibj	317	5	.	.	.
cord-321868-xk4yuibj	318	1	,	,	,
cord-321868-xk4yuibj	318	2	1988a	1988a	CD
cord-321868-xk4yuibj	318	3	;	;	:
cord-321868-xk4yuibj	318	4	Wilson	Wilson	NNP
cord-321868-xk4yuibj	318	5	et	et	NNP
cord-321868-xk4yuibj	318	6	al	al	NNP
cord-321868-xk4yuibj	318	7	.	.	NNP
cord-321868-xk4yuibj	318	8	,	,	,
cord-321868-xk4yuibj	318	9	1988	1988	CD
cord-321868-xk4yuibj	318	10	)	)	-RRB-
cord-321868-xk4yuibj	318	11	.	.	.
cord-321868-xk4yuibj	319	1	This	this	DT
cord-321868-xk4yuibj	319	2	pseudoknot	pseudoknot	NN
cord-321868-xk4yuibj	319	3	structure	structure	NN
cord-321868-xk4yuibj	319	4	may	may	MD
cord-321868-xk4yuibj	319	5	be	be	VB
cord-321868-xk4yuibj	319	6	required	require	VBN
cord-321868-xk4yuibj	319	7	to	to	TO
cord-321868-xk4yuibj	319	8	induce	induce	VB
cord-321868-xk4yuibj	319	9	a	a	DT
cord-321868-xk4yuibj	319	10	translational	translational	JJ
cord-321868-xk4yuibj	319	11	pause	pause	NN
cord-321868-xk4yuibj	319	12	(	(	-LRB-
cord-321868-xk4yuibj	319	13	Jacks	Jacks	NNP
cord-321868-xk4yuibj	319	14	et	et	NNP
cord-321868-xk4yuibj	319	15	al	al	NNP
cord-321868-xk4yuibj	319	16	.	.	NNP
cord-321868-xk4yuibj	319	17	,	,	,
cord-321868-xk4yuibj	319	18	1988a	1988a	CD
cord-321868-xk4yuibj	319	19	)	)	-RRB-
cord-321868-xk4yuibj	319	20	.	.	.
cord-321868-xk4yuibj	320	1	Like	like	IN
cord-321868-xk4yuibj	320	2	the	the	DT
cord-321868-xk4yuibj	320	3	translational	translational	JJ
cord-321868-xk4yuibj	320	4	pause	pause	NN
cord-321868-xk4yuibj	320	5	in	in	IN
cord-321868-xk4yuibj	320	6	the	the	DT
cord-321868-xk4yuibj	320	7	E.	E.	NNP
cord-321868-xk4yuibj	320	8	coli	coli	NNS
cord-321868-xk4yuibj	320	9	case	case	NN
cord-321868-xk4yuibj	320	10	,	,	,
cord-321868-xk4yuibj	320	11	the	the	DT
cord-321868-xk4yuibj	320	12	pause	pause	NN
cord-321868-xk4yuibj	320	13	induced	induce	VBN
cord-321868-xk4yuibj	320	14	by	by	IN
cord-321868-xk4yuibj	320	15	the	the	DT
cord-321868-xk4yuibj	320	16	pseudoknot	pseudoknot	NNP
cord-321868-xk4yuibj	320	17	allows	allow	VBZ
cord-321868-xk4yuibj	320	18	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	320	19	to	to	TO
cord-321868-xk4yuibj	320	20	occur	occur	VB
cord-321868-xk4yuibj	320	21	on	on	IN
cord-321868-xk4yuibj	320	22	the	the	DT
cord-321868-xk4yuibj	320	23	slippery	slippery	JJ
cord-321868-xk4yuibj	320	24	sequence	sequence	NN
cord-321868-xk4yuibj	320	25	.	.	.
cord-321868-xk4yuibj	321	1	Unlike	unlike	IN
cord-321868-xk4yuibj	321	2	E.	E.	NNP
cord-321868-xk4yuibj	321	3	coli	coli	NNS
cord-321868-xk4yuibj	321	4	,	,	,
cord-321868-xk4yuibj	321	5	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	321	6	appears	appear	VBZ
cord-321868-xk4yuibj	321	7	to	to	TO
cord-321868-xk4yuibj	321	8	involve	involve	VB
cord-321868-xk4yuibj	321	9	two	two	CD
cord-321868-xk4yuibj	321	10	tRNAs	trna	NNS
cord-321868-xk4yuibj	321	11	that	that	WDT
cord-321868-xk4yuibj	321	12	recognize	recognize	VBP
cord-321868-xk4yuibj	321	13	two	two	CD
cord-321868-xk4yuibj	321	14	codons	codon	NNS
cord-321868-xk4yuibj	321	15	of	of	IN
cord-321868-xk4yuibj	321	16	the	the	DT
cord-321868-xk4yuibj	321	17	slippery	slippery	JJ
cord-321868-xk4yuibj	321	18	sequence	sequence	NN
cord-321868-xk4yuibj	321	19	in	in	IN
cord-321868-xk4yuibj	321	20	the	the	DT
cord-321868-xk4yuibj	321	21	gag	gag	NN
cord-321868-xk4yuibj	321	22	reading	reading	NN
cord-321868-xk4yuibj	321	23	frame	frame	NN
cord-321868-xk4yuibj	321	24	.	.	.
cord-321868-xk4yuibj	322	1	Jacks	Jacks	NNP
cord-321868-xk4yuibj	322	2	et	et	NNP
cord-321868-xk4yuibj	322	3	al	al	NNP
cord-321868-xk4yuibj	322	4	.	.	.
cord-321868-xk4yuibj	323	1	(	(	-LRB-
cord-321868-xk4yuibj	323	2	1988a	1988a	CD
cord-321868-xk4yuibj	323	3	)	)	-RRB-
cord-321868-xk4yuibj	323	4	showed	show	VBD
cord-321868-xk4yuibj	323	5	that	that	IN
cord-321868-xk4yuibj	323	6	the	the	DT
cord-321868-xk4yuibj	323	7	frameshift	frameshift	NN
cord-321868-xk4yuibj	323	8	event	event	NN
cord-321868-xk4yuibj	323	9	involves	involve	VBZ
cord-321868-xk4yuibj	323	10	a	a	DT
cord-321868-xk4yuibj	323	11	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	323	12	slippage	slippage	NN
cord-321868-xk4yuibj	323	13	of	of	IN
cord-321868-xk4yuibj	323	14	these	these	DT
cord-321868-xk4yuibj	323	15	tRNAs	trna	NNS
cord-321868-xk4yuibj	323	16	in	in	IN
cord-321868-xk4yuibj	323	17	the	the	DT
cord-321868-xk4yuibj	323	18	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	323	19	A	a	NN
cord-321868-xk4yuibj	323	20	and	and	CC
cord-321868-xk4yuibj	323	21	P	p	NN
cord-321868-xk4yuibj	323	22	sites	site	NNS
cord-321868-xk4yuibj	323	23	.	.	.
cord-321868-xk4yuibj	324	1	Because	because	IN
cord-321868-xk4yuibj	324	2	certain	certain	JJ
cord-321868-xk4yuibj	324	3	changes	change	NNS
cord-321868-xk4yuibj	324	4	are	be	VBP
cord-321868-xk4yuibj	324	5	allowed	allow	VBN
cord-321868-xk4yuibj	324	6	in	in	IN
cord-321868-xk4yuibj	324	7	the	the	DT
cord-321868-xk4yuibj	324	8	A	A	NNP
cord-321868-xk4yuibj	324	9	and	and	CC
cord-321868-xk4yuibj	324	10	P	p	NN
cord-321868-xk4yuibj	324	11	site	site	NN
cord-321868-xk4yuibj	324	12	codons	codon	NNS
cord-321868-xk4yuibj	324	13	and	and	CC
cord-321868-xk4yuibj	324	14	because	because	IN
cord-321868-xk4yuibj	324	15	several	several	JJ
cord-321868-xk4yuibj	324	16	different	different	JJ
cord-321868-xk4yuibj	324	17	sites	site	NNS
cord-321868-xk4yuibj	324	18	exist	exist	VBP
cord-321868-xk4yuibj	324	19	(	(	-LRB-
cord-321868-xk4yuibj	324	20	see	see	VB
cord-321868-xk4yuibj	324	21	above	above	RB
cord-321868-xk4yuibj	324	22	)	)	-RRB-
cord-321868-xk4yuibj	324	23	,	,	,
cord-321868-xk4yuibj	324	24	more	more	JJR
cord-321868-xk4yuibj	324	25	than	than	IN
cord-321868-xk4yuibj	324	26	one	one	CD
cord-321868-xk4yuibj	324	27	tRNA	trna	NN
cord-321868-xk4yuibj	324	28	(	(	-LRB-
cord-321868-xk4yuibj	324	29	termed	term	VBN
cord-321868-xk4yuibj	324	30	"	"	``
cord-321868-xk4yuibj	324	31	shifty	shifty	JJ
cord-321868-xk4yuibj	324	32	"	"	''
cord-321868-xk4yuibj	324	33	tRNAs	trna	NNS
cord-321868-xk4yuibj	324	34	)	)	-RRB-
cord-321868-xk4yuibj	324	35	is	be	VBZ
cord-321868-xk4yuibj	324	36	competent	competent	JJ
cord-321868-xk4yuibj	324	37	to	to	TO
cord-321868-xk4yuibj	324	38	frameshift	frameshift	NN
cord-321868-xk4yuibj	324	39	.	.	.
cord-321868-xk4yuibj	325	1	Frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	325	2	in	in	IN
cord-321868-xk4yuibj	325	3	Ty	Ty	NNP
cord-321868-xk4yuibj	325	4	elements	element	NNS
cord-321868-xk4yuibj	325	5	initially	initially	RB
cord-321868-xk4yuibj	325	6	appeared	appear	VBD
cord-321868-xk4yuibj	325	7	to	to	TO
cord-321868-xk4yuibj	325	8	lack	lack	VB
cord-321868-xk4yuibj	325	9	all	all	DT
cord-321868-xk4yuibj	325	10	of	of	IN
cord-321868-xk4yuibj	325	11	the	the	DT
cord-321868-xk4yuibj	325	12	features	feature	NNS
cord-321868-xk4yuibj	325	13	identified	identify	VBN
cord-321868-xk4yuibj	325	14	in	in	IN
cord-321868-xk4yuibj	325	15	other	other	JJ
cord-321868-xk4yuibj	325	16	frameshift	frameshift	NN
cord-321868-xk4yuibj	325	17	sites	site	NNS
cord-321868-xk4yuibj	325	18	.	.	.
cord-321868-xk4yuibj	326	1	No	no	DT
cord-321868-xk4yuibj	326	2	homopolymeric	homopolymeric	JJ
cord-321868-xk4yuibj	326	3	string	string	NN
cord-321868-xk4yuibj	326	4	of	of	IN
cord-321868-xk4yuibj	326	5	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	326	6	is	be	VBZ
cord-321868-xk4yuibj	326	7	necessary	necessary	JJ
cord-321868-xk4yuibj	326	8	in	in	IN
cord-321868-xk4yuibj	326	9	the	the	DT
cord-321868-xk4yuibj	326	10	region	region	NN
cord-321868-xk4yuibj	326	11	of	of	IN
cord-321868-xk4yuibj	326	12	the	the	DT
cord-321868-xk4yuibj	326	13	frameshift	frameshift	NN
cord-321868-xk4yuibj	326	14	event	event	NN
cord-321868-xk4yuibj	326	15	.	.	.
cord-321868-xk4yuibj	327	1	Frameshifting	frameshifting	NN
cord-321868-xk4yuibj	327	2	requires	require	VBZ
cord-321868-xk4yuibj	327	3	neither	neither	CC
cord-321868-xk4yuibj	327	4	a	a	DT
cord-321868-xk4yuibj	327	5	nearby	nearby	JJ
cord-321868-xk4yuibj	327	6	termination	termination	NN
cord-321868-xk4yuibj	327	7	codon	codon	NN
cord-321868-xk4yuibj	327	8	nor	nor	CC
cord-321868-xk4yuibj	327	9	a	a	DT
cord-321868-xk4yuibj	327	10	downstream	downstream	JJ
cord-321868-xk4yuibj	327	11	RNA	RNA	NNP
cord-321868-xk4yuibj	327	12	secondary	secondary	JJ
cord-321868-xk4yuibj	327	13	structure	structure	NN
cord-321868-xk4yuibj	327	14	to	to	TO
cord-321868-xk4yuibj	327	15	induce	induce	VB
cord-321868-xk4yuibj	327	16	a	a	DT
cord-321868-xk4yuibj	327	17	translational	translational	JJ
cord-321868-xk4yuibj	327	18	pause	pause	NN
cord-321868-xk4yuibj	327	19	.	.	.
cord-321868-xk4yuibj	328	1	Previously	previously	RB
cord-321868-xk4yuibj	328	2	,	,	,
cord-321868-xk4yuibj	328	3	we	-PRON-	PRP
cord-321868-xk4yuibj	328	4	showed	show	VBD
cord-321868-xk4yuibj	328	5	that	that	IN
cord-321868-xk4yuibj	328	6	a	a	DT
cord-321868-xk4yuibj	328	7	14	14	CD
cord-321868-xk4yuibj	328	8	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	328	9	sequence	sequence	NN
cord-321868-xk4yuibj	328	10	is	be	VBZ
cord-321868-xk4yuibj	328	11	necessary	necessary	JJ
cord-321868-xk4yuibj	328	12	and	and	CC
cord-321868-xk4yuibj	328	13	sufficient	sufficient	JJ
cord-321868-xk4yuibj	328	14	to	to	TO
cord-321868-xk4yuibj	328	15	induce	induce	VB
cord-321868-xk4yuibj	328	16	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	328	17	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	328	18	even	even	RB
cord-321868-xk4yuibj	328	19	when	when	WRB
cord-321868-xk4yuibj	328	20	placed	place	VBN
cord-321868-xk4yuibj	328	21	within	within	IN
cord-321868-xk4yuibj	328	22	a	a	DT
cord-321868-xk4yuibj	328	23	completely	completely	RB
cord-321868-xk4yuibj	328	24	heterologous	heterologous	JJ
cord-321868-xk4yuibj	328	25	context	context	NN
cord-321868-xk4yuibj	328	26	,	,	,
cord-321868-xk4yuibj	328	27	the	the	DT
cord-321868-xk4yuibj	328	28	HIS4	HIS4	NNP
cord-321868-xk4yuibj	328	29	gene	gene	NN
cord-321868-xk4yuibj	328	30	of	of	IN
cord-321868-xk4yuibj	328	31	yeast	yeast	NN
cord-321868-xk4yuibj	328	32	(	(	-LRB-
cord-321868-xk4yuibj	328	33	Clare	Clare	NNP
cord-321868-xk4yuibj	328	34	et	et	NNP
cord-321868-xk4yuibj	328	35	al	al	NNP
cord-321868-xk4yuibj	328	36	.	.	NNP
cord-321868-xk4yuibj	328	37	,	,	,
cord-321868-xk4yuibj	328	38	1988	1988	CD
cord-321868-xk4yuibj	328	39	)	)	-RRB-
cord-321868-xk4yuibj	328	40	.	.	.
cord-321868-xk4yuibj	329	1	RNA	RNA	NNP
cord-321868-xk4yuibj	329	2	sequencing	sequencing	NN
cord-321868-xk4yuibj	329	3	of	of	IN
cord-321868-xk4yuibj	329	4	an	an	DT
cord-321868-xk4yuibj	329	5	mRNA	mrna	NN
cord-321868-xk4yuibj	329	6	containing	contain	VBG
cord-321868-xk4yuibj	329	7	this	this	DT
cord-321868-xk4yuibj	329	8	frameshift	frameshift	NN
cord-321868-xk4yuibj	329	9	site	site	NN
cord-321868-xk4yuibj	329	10	demonstrated	demonstrate	VBD
cord-321868-xk4yuibj	329	11	that	that	IN
cord-321868-xk4yuibj	329	12	the	the	DT
cord-321868-xk4yuibj	329	13	DNA	DNA	NNP
cord-321868-xk4yuibj	329	14	and	and	CC
cord-321868-xk4yuibj	329	15	RNA	RNA	NNP
cord-321868-xk4yuibj	329	16	sequences	sequence	NNS
cord-321868-xk4yuibj	329	17	are	be	VBP
cord-321868-xk4yuibj	329	18	exactly	exactly	RB
cord-321868-xk4yuibj	329	19	colinear	colinear	JJ
cord-321868-xk4yuibj	329	20	,	,	,
cord-321868-xk4yuibj	329	21	ruling	rule	VBG
cord-321868-xk4yuibj	329	22	out	out	RP
cord-321868-xk4yuibj	329	23	any	any	DT
cord-321868-xk4yuibj	329	24	pretranslational	pretranslational	JJ
cord-321868-xk4yuibj	329	25	mechanism	mechanism	NN
cord-321868-xk4yuibj	329	26	.	.	.
cord-321868-xk4yuibj	330	1	In	in	IN
cord-321868-xk4yuibj	330	2	this	this	DT
cord-321868-xk4yuibj	330	3	report	report	NN
cord-321868-xk4yuibj	330	4	we	-PRON-	PRP
cord-321868-xk4yuibj	330	5	show	show	VBP
cord-321868-xk4yuibj	330	6	that	that	IN
cord-321868-xk4yuibj	330	7	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	330	8	occurs	occur	VBZ
cord-321868-xk4yuibj	330	9	within	within	IN
cord-321868-xk4yuibj	330	10	the	the	DT
cord-321868-xk4yuibj	330	11	14	14	CD
cord-321868-xk4yuibj	330	12	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	330	13	sequence	sequence	NN
cord-321868-xk4yuibj	330	14	.	.	.
cord-321868-xk4yuibj	331	1	Since	since	IN
cord-321868-xk4yuibj	331	2	the	the	DT
cord-321868-xk4yuibj	331	3	sequence	sequence	NN
cord-321868-xk4yuibj	331	4	is	be	VBZ
cord-321868-xk4yuibj	331	5	flanked	flank	VBN
cord-321868-xk4yuibj	331	6	with	with	IN
cord-321868-xk4yuibj	331	7	termination	termination	NN
cord-321868-xk4yuibj	331	8	codons	codon	NNS
cord-321868-xk4yuibj	331	9	,	,	,
cord-321868-xk4yuibj	331	10	upstream	upstream	RB
cord-321868-xk4yuibj	331	11	in	in	IN
cord-321868-xk4yuibj	331	12	the	the	DT
cord-321868-xk4yuibj	331	13	p	p	NN
cord-321868-xk4yuibj	331	14	/	/	SYM
cord-321868-xk4yuibj	331	15	B	b	NN
cord-321868-xk4yuibj	331	16	reading	reading	NN
cord-321868-xk4yuibj	331	17	frame	frame	NN
cord-321868-xk4yuibj	331	18	and	and	CC
cord-321868-xk4yuibj	331	19	downstream	downstream	VB
cord-321868-xk4yuibj	331	20	in	in	IN
cord-321868-xk4yuibj	331	21	the	the	DT
cord-321868-xk4yuibj	331	22	TY4	ty4	NN
cord-321868-xk4yuibj	331	23	reading	reading	NN
cord-321868-xk4yuibj	331	24	frame	frame	NN
cord-321868-xk4yuibj	331	25	,	,	,
cord-321868-xk4yuibj	331	26	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	331	27	is	be	VBZ
cord-321868-xk4yuibj	331	28	confined	confine	VBN
cord-321868-xk4yuibj	331	29	to	to	TO
cord-321868-xk4yuibj	331	30	occur	occur	VB
cord-321868-xk4yuibj	331	31	within	within	IN
cord-321868-xk4yuibj	331	32	the	the	DT
cord-321868-xk4yuibj	331	33	window	window	NN
cord-321868-xk4yuibj	331	34	between	between	IN
cord-321868-xk4yuibj	331	35	the	the	DT
cord-321868-xk4yuibj	331	36	termination	termination	NN
cord-321868-xk4yuibj	331	37	codons	codon	NNS
cord-321868-xk4yuibj	331	38	.	.	.
cord-321868-xk4yuibj	332	1	Expression	expression	NN
cord-321868-xk4yuibj	332	2	of	of	IN
cord-321868-xk4yuibj	332	3	the	the	DT
cord-321868-xk4yuibj	332	4	downstream	downstream	NN
cord-321868-xk4yuibj	332	5	lacZ	lacZ	NNP
cord-321868-xk4yuibj	332	6	gene	gene	NN
cord-321868-xk4yuibj	332	7	,	,	,
cord-321868-xk4yuibj	332	8	in	in	IN
cord-321868-xk4yuibj	332	9	the	the	DT
cord-321868-xk4yuibj	332	10	+	+	CC
cord-321868-xk4yuibj	332	11	l	l	NN
cord-321868-xk4yuibj	332	12	reading	reading	NN
cord-321868-xk4yuibj	332	13	frame	frame	NN
cord-321868-xk4yuibj	332	14	,	,	,
cord-321868-xk4yuibj	332	15	is	be	VBZ
cord-321868-xk4yuibj	332	16	unaffected	unaffected	JJ
cord-321868-xk4yuibj	332	17	by	by	IN
cord-321868-xk4yuibj	332	18	the	the	DT
cord-321868-xk4yuibj	332	19	termination	termination	NN
cord-321868-xk4yuibj	332	20	codons	codon	NNS
cord-321868-xk4yuibj	332	21	.	.	.
cord-321868-xk4yuibj	333	1	We	-PRON-	PRP
cord-321868-xk4yuibj	333	2	show	show	VBP
cord-321868-xk4yuibj	333	3	that	that	IN
cord-321868-xk4yuibj	333	4	the	the	DT
cord-321868-xk4yuibj	333	5	frameshift	frameshift	NN
cord-321868-xk4yuibj	333	6	event	event	NN
cord-321868-xk4yuibj	333	7	is	be	VBZ
cord-321868-xk4yuibj	333	8	directional	directional	JJ
cord-321868-xk4yuibj	333	9	and	and	CC
cord-321868-xk4yuibj	333	10	reading	read	VBG
cord-321868-xk4yuibj	333	11	frame	frame	NN
cord-321868-xk4yuibj	333	12	specific	specific	JJ
cord-321868-xk4yuibj	333	13	.	.	.
cord-321868-xk4yuibj	334	1	Three	three	CD
cord-321868-xk4yuibj	334	2	different	different	JJ
cord-321868-xk4yuibj	334	3	constructs	construct	NNS
cord-321868-xk4yuibj	334	4	allow	allow	VBP
cord-321868-xk4yuibj	334	5	translation	translation	NN
cord-321868-xk4yuibj	334	6	to	to	TO
cord-321868-xk4yuibj	334	7	occur	occur	VB
cord-321868-xk4yuibj	334	8	into	into	IN
cord-321868-xk4yuibj	334	9	each	each	DT
cord-321868-xk4yuibj	334	10	of	of	IN
cord-321868-xk4yuibj	334	11	the	the	DT
cord-321868-xk4yuibj	334	12	three	three	CD
cord-321868-xk4yuibj	334	13	reading	reading	NN
cord-321868-xk4yuibj	334	14	frames	frame	NNS
cord-321868-xk4yuibj	334	15	of	of	IN
cord-321868-xk4yuibj	334	16	the	the	DT
cord-321868-xk4yuibj	334	17	frameshift	frameshift	NN
cord-321868-xk4yuibj	334	18	site	site	NN
cord-321868-xk4yuibj	334	19	.	.	.
cord-321868-xk4yuibj	335	1	For	for	IN
cord-321868-xk4yuibj	335	2	each	each	DT
cord-321868-xk4yuibj	335	3	construct	construct	NN
cord-321868-xk4yuibj	335	4	,	,	,
cord-321868-xk4yuibj	335	5	the	the	DT
cord-321868-xk4yuibj	335	6	/acZ	/acZ	NNP
cord-321868-xk4yuibj	335	7	gene	gene	NN
cord-321868-xk4yuibj	335	8	is	be	VBZ
cord-321868-xk4yuibj	335	9	fused	fuse	VBN
cord-321868-xk4yuibj	335	10	downstream	downstream	RB
cord-321868-xk4yuibj	335	11	in	in	IN
cord-321868-xk4yuibj	335	12	all	all	DT
cord-321868-xk4yuibj	335	13	three	three	CD
cord-321868-xk4yuibj	335	14	reading	read	VBG
cord-321868-xk4yuibj	335	15	frames	frame	NNS
cord-321868-xk4yuibj	335	16	.	.	.
cord-321868-xk4yuibj	336	1	This	this	DT
cord-321868-xk4yuibj	336	2	allows	allow	VBZ
cord-321868-xk4yuibj	336	3	an	an	DT
cord-321868-xk4yuibj	336	4	assay	assay	NN
cord-321868-xk4yuibj	336	5	for	for	IN
cord-321868-xk4yuibj	336	6	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	336	7	from	from	IN
cord-321868-xk4yuibj	336	8	each	each	DT
cord-321868-xk4yuibj	336	9	of	of	IN
cord-321868-xk4yuibj	336	10	the	the	DT
cord-321868-xk4yuibj	336	11	reading	reading	NN
cord-321868-xk4yuibj	336	12	frames	frame	NNS
cord-321868-xk4yuibj	336	13	in	in	IN
cord-321868-xk4yuibj	336	14	either	either	CC
cord-321868-xk4yuibj	336	15	the	the	DT
cord-321868-xk4yuibj	336	16	+	+	SYM
cord-321868-xk4yuibj	336	17	l	l	NN
cord-321868-xk4yuibj	336	18	or	or	CC
cord-321868-xk4yuibj	336	19	-1	-1	JJ
cord-321868-xk4yuibj	336	20	direction	direction	NN
cord-321868-xk4yuibj	336	21	.	.	.
cord-321868-xk4yuibj	337	1	Translation	translation	NN
cord-321868-xk4yuibj	337	2	into	into	IN
cord-321868-xk4yuibj	337	3	the	the	DT
cord-321868-xk4yuibj	337	4	frameshift	frameshift	NN
cord-321868-xk4yuibj	337	5	sequence	sequence	NN
cord-321868-xk4yuibj	337	6	in	in	IN
cord-321868-xk4yuibj	337	7	the	the	DT
cord-321868-xk4yuibj	337	8	0	0	CD
cord-321868-xk4yuibj	337	9	,	,	,
cord-321868-xk4yuibj	337	10	or	or	CC
cord-321868-xk4yuibj	337	11	p	p	NN
cord-321868-xk4yuibj	337	12	/	/	SYM
cord-321868-xk4yuibj	337	13	A	a	NN
cord-321868-xk4yuibj	337	14	,	,	,
cord-321868-xk4yuibj	337	15	reading	reading	NN
cord-321868-xk4yuibj	337	16	frame	frame	NN
cord-321868-xk4yuibj	337	17	(	(	-LRB-
cord-321868-xk4yuibj	337	18	the	the	DT
cord-321868-xk4yuibj	337	19	normal	normal	JJ
cord-321868-xk4yuibj	337	20	reading	reading	NN
cord-321868-xk4yuibj	337	21	frame	frame	NN
cord-321868-xk4yuibj	337	22	of	of	IN
cord-321868-xk4yuibj	337	23	the	the	DT
cord-321868-xk4yuibj	337	24	frameshift	frameshift	NN
cord-321868-xk4yuibj	337	25	site	site	NN
cord-321868-xk4yuibj	337	26	)	)	-RRB-
cord-321868-xk4yuibj	337	27	allows	allow	VBZ
cord-321868-xk4yuibj	337	28	wild	wild	JJ
cord-321868-xk4yuibj	337	29	-	-	HYPH
cord-321868-xk4yuibj	337	30	type	type	NN
cord-321868-xk4yuibj	337	31	levels	level	NNS
cord-321868-xk4yuibj	337	32	of	of	IN
cord-321868-xk4yuibj	337	33	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	337	34	in	in	IN
cord-321868-xk4yuibj	337	35	the	the	DT
cord-321868-xk4yuibj	337	36	+	+	CC
cord-321868-xk4yuibj	337	37	l	l	NN
cord-321868-xk4yuibj	337	38	direction	direction	NN
cord-321868-xk4yuibj	337	39	.	.	.
cord-321868-xk4yuibj	338	1	However	however	RB
cord-321868-xk4yuibj	338	2	,	,	,
cord-321868-xk4yuibj	338	3	translating	translate	VBG
cord-321868-xk4yuibj	338	4	the	the	DT
cord-321868-xk4yuibj	338	5	+	+	SYM
cord-321868-xk4yuibj	338	6	l	l	NN
cord-321868-xk4yuibj	338	7	or	or	CC
cord-321868-xk4yuibj	338	8	-1	-1	IN
cord-321868-xk4yuibj	338	9	reading	reading	NN
cord-321868-xk4yuibj	338	10	frames	frame	NNS
cord-321868-xk4yuibj	338	11	allows	allow	VBZ
cord-321868-xk4yuibj	338	12	no	no	DT
cord-321868-xk4yuibj	338	13	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	338	14	in	in	IN
cord-321868-xk4yuibj	338	15	the	the	DT
cord-321868-xk4yuibj	338	16	+	+	CC
cord-321868-xk4yuibj	338	17	l	l	NN
cord-321868-xk4yuibj	338	18	direction	direction	NN
cord-321868-xk4yuibj	338	19	,	,	,
cord-321868-xk4yuibj	338	20	demonstrating	demonstrate	VBG
cord-321868-xk4yuibj	338	21	the	the	DT
cord-321868-xk4yuibj	338	22	reading	reading	NN
cord-321868-xk4yuibj	338	23	frame	frame	NN
cord-321868-xk4yuibj	338	24	specificity	specificity	NN
cord-321868-xk4yuibj	338	25	of	of	IN
cord-321868-xk4yuibj	338	26	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	338	27	.	.	.
cord-321868-xk4yuibj	339	1	Frameshifting	frameshifting	NN
cord-321868-xk4yuibj	339	2	does	do	VBZ
cord-321868-xk4yuibj	339	3	not	not	RB
cord-321868-xk4yuibj	339	4	occur	occur	VB
cord-321868-xk4yuibj	339	5	in	in	IN
cord-321868-xk4yuibj	339	6	the	the	DT
cord-321868-xk4yuibj	339	7	-1	-1	JJ
cord-321868-xk4yuibj	339	8	direction	direction	NN
cord-321868-xk4yuibj	339	9	from	from	IN
cord-321868-xk4yuibj	339	10	any	any	DT
cord-321868-xk4yuibj	339	11	of	of	IN
cord-321868-xk4yuibj	339	12	the	the	DT
cord-321868-xk4yuibj	339	13	three	three	CD
cord-321868-xk4yuibj	339	14	reading	reading	NN
cord-321868-xk4yuibj	339	15	frames	frame	NNS
cord-321868-xk4yuibj	339	16	,	,	,
cord-321868-xk4yuibj	339	17	indicating	indicate	VBG
cord-321868-xk4yuibj	339	18	that	that	IN
cord-321868-xk4yuibj	339	19	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	339	20	is	be	VBZ
cord-321868-xk4yuibj	339	21	directional	directional	JJ
cord-321868-xk4yuibj	339	22	.	.	.
cord-321868-xk4yuibj	340	1	A	a	DT
cord-321868-xk4yuibj	340	2	Model	model	NN
cord-321868-xk4yuibj	340	3	for	for	IN
cord-321868-xk4yuibj	340	4	Ty	Ty	NNP
cord-321868-xk4yuibj	340	5	Frameshifting	Frameshifting	NNP
cord-321868-xk4yuibj	340	6	Deletion	Deletion	NNP
cord-321868-xk4yuibj	340	7	analysis	analysis	NN
cord-321868-xk4yuibj	340	8	and	and	CC
cord-321868-xk4yuibj	340	9	missense	missense	NN
cord-321868-xk4yuibj	340	10	mutagenesis	mutagenesis	NN
cord-321868-xk4yuibj	340	11	define	define	VBP
cord-321868-xk4yuibj	340	12	7	7	CD
cord-321868-xk4yuibj	340	13	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	340	14	essential	essential	JJ
cord-321868-xk4yuibj	340	15	for	for	IN
cord-321868-xk4yuibj	340	16	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	340	17	.	.	.
cord-321868-xk4yuibj	341	1	This	this	DT
cord-321868-xk4yuibj	341	2	sequence	sequence	NN
cord-321868-xk4yuibj	341	3	,	,	,
cord-321868-xk4yuibj	341	4	CUU	CUU	NNP
cord-321868-xk4yuibj	341	5	-	-	HYPH
cord-321868-xk4yuibj	341	6	AGG	agg	NN
cord-321868-xk4yuibj	341	7	-	-	HYPH
cord-321868-xk4yuibj	341	8	C	C	NNP
cord-321868-xk4yuibj	341	9	,	,	,
cord-321868-xk4yuibj	341	10	has	have	VBZ
cord-321868-xk4yuibj	341	11	some	some	DT
cord-321868-xk4yuibj	341	12	interesting	interesting	JJ
cord-321868-xk4yuibj	341	13	characteristics	characteristic	NNS
cord-321868-xk4yuibj	341	14	.	.	.
cord-321868-xk4yuibj	342	1	Over	over	IN
cord-321868-xk4yuibj	342	2	-	-	HYPH
cord-321868-xk4yuibj	342	3	lapping	lap	VBG
cord-321868-xk4yuibj	342	4	leucine	leucine	NN
cord-321868-xk4yuibj	342	5	codons	codon	NNS
cord-321868-xk4yuibj	342	6	,	,	,
cord-321868-xk4yuibj	342	7	CUU	CUU	NNP
cord-321868-xk4yuibj	342	8	in	in	IN
cord-321868-xk4yuibj	342	9	the	the	DT
cord-321868-xk4yuibj	342	10	0	0	CD
cord-321868-xk4yuibj	342	11	frame	frame	NN
cord-321868-xk4yuibj	342	12	and	and	CC
cord-321868-xk4yuibj	342	13	UUA	UUA	NNP
cord-321868-xk4yuibj	342	14	in	in	IN
cord-321868-xk4yuibj	342	15	the	the	DT
cord-321868-xk4yuibj	342	16	+	+	NN
cord-321868-xk4yuibj	342	17	l	l	NN
cord-321868-xk4yuibj	342	18	frame	frame	NN
cord-321868-xk4yuibj	342	19	,	,	,
cord-321868-xk4yuibj	342	20	are	be	VBP
cord-321868-xk4yuibj	342	21	recognized	recognize	VBN
cord-321868-xk4yuibj	342	22	by	by	IN
cord-321868-xk4yuibj	342	23	a	a	DT
cord-321868-xk4yuibj	342	24	single	single	JJ
cord-321868-xk4yuibj	342	25	isoacceptor	isoacceptor	NN
cord-321868-xk4yuibj	342	26	in	in	IN
cord-321868-xk4yuibj	342	27	yeast	yeast	NN
cord-321868-xk4yuibj	342	28	,	,	,
cord-321868-xk4yuibj	342	29	tRNA	tRNA	NNP
cord-321868-xk4yuibj	342	30	&	&	CC
cord-321868-xk4yuibj	342	31	.	.	.
cord-321868-xk4yuibj	343	1	This	this	DT
cord-321868-xk4yuibj	343	2	tRNA	trna	NN
cord-321868-xk4yuibj	343	3	can	can	MD
cord-321868-xk4yuibj	343	4	recognize	recognize	VB
cord-321868-xk4yuibj	343	5	all	all	DT
cord-321868-xk4yuibj	343	6	six	six	CD
cord-321868-xk4yuibj	343	7	of	of	IN
cord-321868-xk4yuibj	343	8	the	the	DT
cord-321868-xk4yuibj	343	9	leucine	leucine	NN
cord-321868-xk4yuibj	343	10	codons	codon	NNS
cord-321868-xk4yuibj	343	11	by	by	IN
cord-321868-xk4yuibj	343	12	virtue	virtue	NN
cord-321868-xk4yuibj	343	13	of	of	IN
cord-321868-xk4yuibj	343	14	an	an	DT
cord-321868-xk4yuibj	343	15	unmodified	unmodified	JJ
cord-321868-xk4yuibj	343	16	uracil	uracil	NN
cord-321868-xk4yuibj	343	17	in	in	IN
cord-321868-xk4yuibj	343	18	its	-PRON-	PRP$
cord-321868-xk4yuibj	343	19	wobble	wobble	NN
cord-321868-xk4yuibj	343	20	position	position	NN
cord-321868-xk4yuibj	343	21	(	(	-LRB-
cord-321868-xk4yuibj	343	22	Randerath	Randerath	NNP
cord-321868-xk4yuibj	343	23	et	et	FW
cord-321868-xk4yuibj	343	24	al	al	NNP
cord-321868-xk4yuibj	343	25	.	.	NNP
cord-321868-xk4yuibj	343	26	,	,	,
cord-321868-xk4yuibj	343	27	1979	1979	CD
cord-321868-xk4yuibj	343	28	;	;	:
cord-321868-xk4yuibj	343	29	Weissenbach	Weissenbach	NNP
cord-321868-xk4yuibj	343	30	et	et	FW
cord-321868-xk4yuibj	343	31	al	al	NNP
cord-321868-xk4yuibj	343	32	.	.	NNP
cord-321868-xk4yuibj	343	33	,	,	,
cord-321868-xk4yuibj	343	34	1977	1977	CD
cord-321868-xk4yuibj	343	35	)	)	-RRB-
cord-321868-xk4yuibj	343	36	.	.	.
cord-321868-xk4yuibj	344	1	Modified	modified	JJ
cord-321868-xk4yuibj	344	2	uracil	uracil	NN
cord-321868-xk4yuibj	344	3	residues	residue	NNS
cord-321868-xk4yuibj	344	4	recognize	recognize	VBP
cord-321868-xk4yuibj	344	5	only	only	RB
cord-321868-xk4yuibj	344	6	purines	purine	NNS
cord-321868-xk4yuibj	344	7	,	,	,
cord-321868-xk4yuibj	344	8	whereas	whereas	IN
cord-321868-xk4yuibj	344	9	an	an	DT
cord-321868-xk4yuibj	344	10	unmodified	unmodified	JJ
cord-321868-xk4yuibj	344	11	uracil	uracil	NN
cord-321868-xk4yuibj	344	12	can	can	MD
cord-321868-xk4yuibj	344	13	recognize	recognize	VB
cord-321868-xk4yuibj	344	14	all	all	DT
cord-321868-xk4yuibj	344	15	four	four	CD
cord-321868-xk4yuibj	344	16	bases	basis	NNS
cord-321868-xk4yuibj	344	17	(	(	-LRB-
cord-321868-xk4yuibj	344	18	Heckman	Heckman	NNP
cord-321868-xk4yuibj	344	19	et	et	NNP
cord-321868-xk4yuibj	344	20	al	al	NNP
cord-321868-xk4yuibj	344	21	.	.	NNP
cord-321868-xk4yuibj	344	22	,	,	,
cord-321868-xk4yuibj	344	23	1980	1980	CD
cord-321868-xk4yuibj	344	24	;	;	:
cord-321868-xk4yuibj	344	25	Sibler	Sibler	NNP
cord-321868-xk4yuibj	344	26	et	et	NNP
cord-321868-xk4yuibj	344	27	al	al	NNP
cord-321868-xk4yuibj	344	28	.	.	NNP
cord-321868-xk4yuibj	344	29	,	,	,
cord-321868-xk4yuibj	344	30	1988	1988	CD
cord-321868-xk4yuibj	344	31	)	)	-RRB-
cord-321868-xk4yuibj	344	32	;	;	,
cord-321868-xk4yuibj	344	33	unmodified	unmodified	JJ
cord-321868-xk4yuibj	344	34	uracil	uracil	NN
cord-321868-xk4yuibj	344	35	residues	residue	NNS
cord-321868-xk4yuibj	344	36	(	(	-LRB-
cord-321868-xk4yuibj	344	37	and	and	CC
cord-321868-xk4yuibj	344	38	consequently	consequently	RB
cord-321868-xk4yuibj	344	39	,	,	,
cord-321868-xk4yuibj	344	40	recognition	recognition	NN
cord-321868-xk4yuibj	344	41	of	of	IN
cord-321868-xk4yuibj	344	42	four	four	CD
cord-321868-xk4yuibj	344	43	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	344	44	)	)	-RRB-
cord-321868-xk4yuibj	344	45	is	be	VBZ
cord-321868-xk4yuibj	344	46	common	common	JJ
cord-321868-xk4yuibj	344	47	in	in	IN
cord-321868-xk4yuibj	344	48	mitochondrial	mitochondrial	JJ
cord-321868-xk4yuibj	344	49	tRNAs	trna	NNS
cord-321868-xk4yuibj	345	1	(	(	-LRB-
cord-321868-xk4yuibj	345	2	Barrel1	Barrel1	NNP
cord-321868-xk4yuibj	345	3	et	et	NNP
cord-321868-xk4yuibj	345	4	al	al	NNP
cord-321868-xk4yuibj	345	5	.	.	NNP
cord-321868-xk4yuibj	345	6	,	,	,
cord-321868-xk4yuibj	345	7	1980	1980	CD
cord-321868-xk4yuibj	345	8	;	;	.
cord-321868-xk4yuibj	346	1	Bonitz	Bonitz	NNP
cord-321868-xk4yuibj	346	2	et	et	NNP
cord-321868-xk4yuibj	346	3	al	al	NNP
cord-321868-xk4yuibj	346	4	.	.	NNP
cord-321868-xk4yuibj	346	5	,	,	,
cord-321868-xk4yuibj	346	6	1980	1980	CD
cord-321868-xk4yuibj	346	7	;	;	:
cord-321868-xk4yuibj	346	8	Heckman	Heckman	NNP
cord-321868-xk4yuibj	346	9	et	et	NNP
cord-321868-xk4yuibj	346	10	al	al	NNP
cord-321868-xk4yuibj	346	11	.	.	NNP
cord-321868-xk4yuibj	346	12	,	,	,
cord-321868-xk4yuibj	346	13	1980	1980	CD
cord-321868-xk4yuibj	346	14	;	;	:
cord-321868-xk4yuibj	346	15	Sibler	Sibler	NNP
cord-321868-xk4yuibj	346	16	et	et	NNP
cord-321868-xk4yuibj	346	17	al	al	NNP
cord-321868-xk4yuibj	346	18	.	.	NNP
cord-321868-xk4yuibj	346	19	,	,	,
cord-321868-xk4yuibj	346	20	1988	1988	CD
cord-321868-xk4yuibj	346	21	)	)	-RRB-
cord-321868-xk4yuibj	346	22	,	,	,
cord-321868-xk4yuibj	346	23	where	where	WRB
cord-321868-xk4yuibj	346	24	a	a	DT
cord-321868-xk4yuibj	346	25	much	much	RB
cord-321868-xk4yuibj	346	26	smaller	small	JJR
cord-321868-xk4yuibj	346	27	number	number	NN
cord-321868-xk4yuibj	346	28	of	of	IN
cord-321868-xk4yuibj	346	29	tRNAs	trna	NNS
cord-321868-xk4yuibj	346	30	are	be	VBP
cord-321868-xk4yuibj	346	31	sufficient	sufficient	JJ
cord-321868-xk4yuibj	346	32	to	to	TO
cord-321868-xk4yuibj	346	33	translate	translate	VB
cord-321868-xk4yuibj	346	34	all	all	PDT
cord-321868-xk4yuibj	346	35	the	the	DT
cord-321868-xk4yuibj	346	36	codons	codon	NNS
cord-321868-xk4yuibj	346	37	of	of	IN
cord-321868-xk4yuibj	346	38	the	the	DT
cord-321868-xk4yuibj	346	39	mitochondrial	mitochondrial	JJ
cord-321868-xk4yuibj	346	40	genome	genome	NN
cord-321868-xk4yuibj	346	41	.	.	.
cord-321868-xk4yuibj	347	1	This	this	DT
cord-321868-xk4yuibj	347	2	characteristic	characteristic	NN
cord-321868-xk4yuibj	347	3	makes	make	VBZ
cord-321868-xk4yuibj	347	4	this	this	DT
cord-321868-xk4yuibj	347	5	tRNA	trna	NN
cord-321868-xk4yuibj	347	6	an	an	DT
cord-321868-xk4yuibj	347	7	ideal	ideal	JJ
cord-321868-xk4yuibj	347	8	candidate	candidate	NN
cord-321868-xk4yuibj	347	9	for	for	IN
cord-321868-xk4yuibj	347	10	a	a	DT
cord-321868-xk4yuibj	347	11	shifty	shifty	JJ
cord-321868-xk4yuibj	347	12	tRNA	tRNA	NNP
cord-321868-xk4yuibj	347	13	,	,	,
cord-321868-xk4yuibj	347	14	as	as	IN
cord-321868-xk4yuibj	347	15	it	-PRON-	PRP
cord-321868-xk4yuibj	347	16	is	be	VBZ
cord-321868-xk4yuibj	347	17	a	a	DT
cord-321868-xk4yuibj	347	18	major	major	JJ
cord-321868-xk4yuibj	347	19	isoacceptor	isoacceptor	NN
cord-321868-xk4yuibj	347	20	for	for	IN
cord-321868-xk4yuibj	347	21	leucine	leucine	NN
cord-321868-xk4yuibj	347	22	(	(	-LRB-
cord-321868-xk4yuibj	347	23	present	present	JJ
cord-321868-xk4yuibj	347	24	at	at	IN
cord-321868-xk4yuibj	347	25	48	48	CD
cord-321868-xk4yuibj	347	26	%	%	NN
cord-321868-xk4yuibj	347	27	the	the	DT
cord-321868-xk4yuibj	347	28	level	level	NN
cord-321868-xk4yuibj	347	29	of	of	IN
cord-321868-xk4yuibj	347	30	the	the	DT
cord-321868-xk4yuibj	347	31	most	most	RBS
cord-321868-xk4yuibj	347	32	abundant	abundant	JJ
cord-321868-xk4yuibj	347	33	isoacceptor	isoacceptor	NN
cord-321868-xk4yuibj	347	34	,	,	,
cord-321868-xk4yuibj	347	35	tRNAcAA	tRNAcAA	NNP
cord-321868-xk4yuibj	347	36	,	,	,
cord-321868-xk4yuibj	347	37	Leu	Leu	NNP
cord-321868-xk4yuibj	347	38	*	*	NFP
cord-321868-xk4yuibj	347	39	Ikemura	Ikemura	NNP
cord-321868-xk4yuibj	347	40	,	,	,
cord-321868-xk4yuibj	347	41	1982	1982	CD
cord-321868-xk4yuibj	347	42	)	)	-RRB-
cord-321868-xk4yuibj	347	43	and	and	CC
cord-321868-xk4yuibj	347	44	satisfies	satisfie	NNS
cord-321868-xk4yuibj	347	45	wobble	wobble	VBP
cord-321868-xk4yuibj	347	46	rules	rule	NNS
cord-321868-xk4yuibj	347	47	in	in	IN
cord-321868-xk4yuibj	347	48	both	both	DT
cord-321868-xk4yuibj	347	49	reading	read	VBG
cord-321868-xk4yuibj	347	50	frames	frame	NNS
cord-321868-xk4yuibj	347	51	.	.	.
cord-321868-xk4yuibj	348	1	The	the	DT
cord-321868-xk4yuibj	348	2	second	second	JJ
cord-321868-xk4yuibj	348	3	unique	unique	JJ
cord-321868-xk4yuibj	348	4	characteristic	characteristic	NN
cord-321868-xk4yuibj	348	5	of	of	IN
cord-321868-xk4yuibj	348	6	this	this	DT
cord-321868-xk4yuibj	348	7	sequence	sequence	NN
cord-321868-xk4yuibj	348	8	is	be	VBZ
cord-321868-xk4yuibj	348	9	the	the	DT
cord-321868-xk4yuibj	348	10	AGG	agg	NN
cord-321868-xk4yuibj	348	11	codon	codon	NN
cord-321868-xk4yuibj	348	12	.	.	.
cord-321868-xk4yuibj	349	1	This	this	DT
cord-321868-xk4yuibj	349	2	codon	codon	NN
cord-321868-xk4yuibj	349	3	is	be	VBZ
cord-321868-xk4yuibj	349	4	recognized	recognize	VBN
cord-321868-xk4yuibj	349	5	by	by	IN
cord-321868-xk4yuibj	349	6	a	a	DT
cord-321868-xk4yuibj	349	7	low	low	JJ
cord-321868-xk4yuibj	349	8	-	-	HYPH
cord-321868-xk4yuibj	349	9	abundance	abundance	NN
cord-321868-xk4yuibj	349	10	tRNA	trna	NN
cord-321868-xk4yuibj	349	11	,	,	,
cord-321868-xk4yuibj	349	12	tRNA$'u	tRNA$'u	NNP
cord-321868-xk4yuibj	349	13	,	,	,
cord-321868-xk4yuibj	349	14	a	a	DT
cord-321868-xk4yuibj	349	15	single	single	JJ
cord-321868-xk4yuibj	349	16	-	-	HYPH
cord-321868-xk4yuibj	349	17	copy	copy	NN
cord-321868-xk4yuibj	349	18	essential	essential	JJ
cord-321868-xk4yuibj	349	19	gene	gene	NN
cord-321868-xk4yuibj	349	20	.	.	.
cord-321868-xk4yuibj	350	1	These	these	DT
cord-321868-xk4yuibj	350	2	two	two	CD
cord-321868-xk4yuibj	350	3	characteristics	characteristic	NNS
cord-321868-xk4yuibj	350	4	suggest	suggest	VBP
cord-321868-xk4yuibj	350	5	a	a	DT
cord-321868-xk4yuibj	350	6	model	model	NN
cord-321868-xk4yuibj	350	7	for	for	IN
cord-321868-xk4yuibj	350	8	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	350	9	that	that	WDT
cord-321868-xk4yuibj	350	10	retains	retain	VBZ
cord-321868-xk4yuibj	350	11	features	feature	NNS
cord-321868-xk4yuibj	350	12	of	of	IN
cord-321868-xk4yuibj	350	13	frameshift	frameshift	NN
cord-321868-xk4yuibj	350	14	sites	site	NNS
cord-321868-xk4yuibj	350	15	in	in	IN
cord-321868-xk4yuibj	350	16	other	other	JJ
cord-321868-xk4yuibj	350	17	systems	system	NNS
cord-321868-xk4yuibj	350	18	.	.	.
cord-321868-xk4yuibj	351	1	A	a	DT
cord-321868-xk4yuibj	351	2	slippery	slippery	JJ
cord-321868-xk4yuibj	351	3	sequence	sequence	NN
cord-321868-xk4yuibj	351	4	,	,	,
cord-321868-xk4yuibj	351	5	CUU	CUU	NNP
cord-321868-xk4yuibj	351	6	in	in	IN
cord-321868-xk4yuibj	351	7	the	the	DT
cord-321868-xk4yuibj	351	8	0	0	CD
cord-321868-xk4yuibj	351	9	frame	frame	NN
cord-321868-xk4yuibj	351	10	to	to	IN
cord-321868-xk4yuibj	351	11	UUA	UUA	NNP
cord-321868-xk4yuibj	351	12	in	in	IN
cord-321868-xk4yuibj	351	13	the	the	DT
cord-321868-xk4yuibj	351	14	+	+	NN
cord-321868-xk4yuibj	351	15	l	l	NN
cord-321868-xk4yuibj	351	16	frame	frame	NN
cord-321868-xk4yuibj	351	17	,	,	,
cord-321868-xk4yuibj	351	18	is	be	VBZ
cord-321868-xk4yuibj	351	19	possible	possible	JJ
cord-321868-xk4yuibj	351	20	because	because	IN
cord-321868-xk4yuibj	351	21	of	of	IN
cord-321868-xk4yuibj	351	22	the	the	DT
cord-321868-xk4yuibj	351	23	unique	unique	NNP
cord-321868-xk4yuibj	351	24	tRNA	tRNA	NNP
cord-321868-xk4yuibj	351	25	&	&	CC
cord-321868-xk4yuibj	351	26	.	.	.
cord-321868-xk4yuibj	352	1	A	a	DT
cord-321868-xk4yuibj	352	2	translational	translational	JJ
cord-321868-xk4yuibj	352	3	pause	pause	NN
cord-321868-xk4yuibj	352	4	could	could	MD
cord-321868-xk4yuibj	352	5	be	be	VB
cord-321868-xk4yuibj	352	6	induced	induce	VBN
cord-321868-xk4yuibj	352	7	by	by	IN
cord-321868-xk4yuibj	352	8	the	the	DT
cord-321868-xk4yuibj	352	9	low	low	JJ
cord-321868-xk4yuibj	352	10	-	-	HYPH
cord-321868-xk4yuibj	352	11	abundance	abundance	NN
cord-321868-xk4yuibj	352	12	tRNA'$$	trna'$$	NN
cord-321868-xk4yuibj	352	13	,	,	,
cord-321868-xk4yuibj	352	14	.	.	.
cord-321868-xk4yuibj	353	1	Pausing	pause	VBG
cord-321868-xk4yuibj	353	2	and	and	CC
cord-321868-xk4yuibj	353	3	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	353	4	at	at	IN
cord-321868-xk4yuibj	353	5	"	"	``
cord-321868-xk4yuibj	353	6	hungry	hungry	JJ
cord-321868-xk4yuibj	353	7	"	"	''
cord-321868-xk4yuibj	353	8	codons	codon	NNS
cord-321868-xk4yuibj	353	9	,	,	,
cord-321868-xk4yuibj	353	10	codons	codon	NNS
cord-321868-xk4yuibj	353	11	whose	whose	WP$
cord-321868-xk4yuibj	353	12	cognate	cognate	JJ
cord-321868-xk4yuibj	353	13	tRNA	trna	NN
cord-321868-xk4yuibj	353	14	is	be	VBZ
cord-321868-xk4yuibj	353	15	in	in	IN
cord-321868-xk4yuibj	353	16	short	short	JJ
cord-321868-xk4yuibj	353	17	supply	supply	NN
cord-321868-xk4yuibj	353	18	,	,	,
cord-321868-xk4yuibj	353	19	occurs	occur	VBZ
cord-321868-xk4yuibj	353	20	in	in	IN
cord-321868-xk4yuibj	353	21	other	other	JJ
cord-321868-xk4yuibj	353	22	systems	system	NNS
cord-321868-xk4yuibj	353	23	(	(	-LRB-
cord-321868-xk4yuibj	353	24	Spanjaard	Spanjaard	NNP
cord-321868-xk4yuibj	353	25	and	and	CC
cord-321868-xk4yuibj	353	26	van	van	NNP
cord-321868-xk4yuibj	353	27	Duin	Duin	NNP
cord-321868-xk4yuibj	353	28	,	,	,
cord-321868-xk4yuibj	353	29	1988	1988	CD
cord-321868-xk4yuibj	353	30	;	;	:
cord-321868-xk4yuibj	353	31	and	and	CC
cord-321868-xk4yuibj	353	32	,	,	,
cord-321868-xk4yuibj	353	33	in	in	IN
cord-321868-xk4yuibj	353	34	Ty	Ty	NNP
cord-321868-xk4yuibj	353	35	elements	element	NNS
cord-321868-xk4yuibj	353	36	,	,	,
cord-321868-xk4yuibj	353	37	may	may	MD
cord-321868-xk4yuibj	353	38	satisfy	satisfy	VB
cord-321868-xk4yuibj	353	39	the	the	DT
cord-321868-xk4yuibj	353	40	apparent	apparent	JJ
cord-321868-xk4yuibj	353	41	requirement	requirement	NN
cord-321868-xk4yuibj	353	42	for	for	IN
cord-321868-xk4yuibj	353	43	a	a	DT
cord-321868-xk4yuibj	353	44	translational	translational	JJ
cord-321868-xk4yuibj	353	45	pause	pause	NN
cord-321868-xk4yuibj	353	46	to	to	TO
cord-321868-xk4yuibj	353	47	induce	induce	VB
cord-321868-xk4yuibj	353	48	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	353	49	.	.	.
cord-321868-xk4yuibj	354	1	The	the	DT
cord-321868-xk4yuibj	354	2	model	model	NN
cord-321868-xk4yuibj	354	3	,	,	,
cord-321868-xk4yuibj	354	4	diagrammed	diagram	VBN
cord-321868-xk4yuibj	354	5	in	in	IN
cord-321868-xk4yuibj	354	6	Figure	Figure	NNP
cord-321868-xk4yuibj	354	7	4	4	CD
cord-321868-xk4yuibj	354	8	,	,	,
cord-321868-xk4yuibj	354	9	states	state	VBZ
cord-321868-xk4yuibj	354	10	that	that	WDT
cord-321868-xk4yuibj	354	11	ribosomes	ribosomes	VBP
cord-321868-xk4yuibj	354	12	encountering	encounter	VBG
cord-321868-xk4yuibj	354	13	the	the	DT
cord-321868-xk4yuibj	354	14	AGG	agg	NN
cord-321868-xk4yuibj	354	15	codon	codon	NN
cord-321868-xk4yuibj	354	16	pause	pause	NN
cord-321868-xk4yuibj	354	17	because	because	IN
cord-321868-xk4yuibj	354	18	of	of	IN
cord-321868-xk4yuibj	354	19	the	the	DT
cord-321868-xk4yuibj	354	20	low	low	JJ
cord-321868-xk4yuibj	354	21	availability	availability	NN
cord-321868-xk4yuibj	354	22	of	of	IN
cord-321868-xk4yuibj	354	23	tRNA$u	trna$u	NN
cord-321868-xk4yuibj	354	24	.	.	.
cord-321868-xk4yuibj	355	1	Peptidyl	Peptidyl	NNP
cord-321868-xk4yuibj	355	2	-	-	HYPH
cord-321868-xk4yuibj	355	3	tRNA&e	tRNA&e	NNP
cord-321868-xk4yuibj	355	4	,	,	,
cord-321868-xk4yuibj	355	5	in	in	IN
cord-321868-xk4yuibj	355	6	the	the	DT
cord-321868-xk4yuibj	355	7	P	p	NN
cord-321868-xk4yuibj	355	8	site	site	NN
cord-321868-xk4yuibj	355	9	of	of	IN
cord-321868-xk4yuibj	355	10	the	the	DT
cord-321868-xk4yuibj	355	11	ribosome	ribosome	NN
cord-321868-xk4yuibj	355	12	(	(	-LRB-
cord-321868-xk4yuibj	355	13	on	on	IN
cord-321868-xk4yuibj	355	14	the	the	DT
cord-321868-xk4yuibj	355	15	CUU	CUU	NNP
cord-321868-xk4yuibj	355	16	codon	codon	NN
cord-321868-xk4yuibj	355	17	)	)	-RRB-
cord-321868-xk4yuibj	355	18	,	,	,
cord-321868-xk4yuibj	355	19	slips	slip	VBZ
cord-321868-xk4yuibj	355	20	forward	forward	RB
cord-321868-xk4yuibj	356	1	+	+	CC
cord-321868-xk4yuibj	357	1	l	l	NN
cord-321868-xk4yuibj	357	2	during	during	IN
cord-321868-xk4yuibj	357	3	the	the	DT
cord-321868-xk4yuibj	357	4	pause	pause	NN
cord-321868-xk4yuibj	357	5	onto	onto	IN
cord-321868-xk4yuibj	357	6	the	the	DT
cord-321868-xk4yuibj	357	7	UUA	UUA	NNP
cord-321868-xk4yuibj	357	8	codon	codon	NN
cord-321868-xk4yuibj	357	9	.	.	.
cord-321868-xk4yuibj	358	1	Translation	translation	NN
cord-321868-xk4yuibj	358	2	continues	continue	VBZ
cord-321868-xk4yuibj	358	3	in	in	IN
cord-321868-xk4yuibj	358	4	the	the	DT
cord-321868-xk4yuibj	358	5	+	+	CC
cord-321868-xk4yuibj	358	6	l	l	NN
cord-321868-xk4yuibj	358	7	reading	reading	NN
cord-321868-xk4yuibj	358	8	frame	frame	NN
cord-321868-xk4yuibj	358	9	.	.	.
cord-321868-xk4yuibj	359	1	We	-PRON-	PRP
cord-321868-xk4yuibj	359	2	have	have	VBP
cord-321868-xk4yuibj	359	3	provided	provide	VBN
cord-321868-xk4yuibj	359	4	experimental	experimental	JJ
cord-321868-xk4yuibj	359	5	evidence	evidence	NN
cord-321868-xk4yuibj	359	6	to	to	TO
cord-321868-xk4yuibj	359	7	support	support	VB
cord-321868-xk4yuibj	359	8	this	this	DT
cord-321868-xk4yuibj	359	9	hypothesis	hypothesis	NN
cord-321868-xk4yuibj	359	10	.	.	.
cord-321868-xk4yuibj	360	1	Peptide	peptide	NN
cord-321868-xk4yuibj	360	2	sequencing	sequencing	NN
cord-321868-xk4yuibj	360	3	through	through	IN
cord-321868-xk4yuibj	360	4	the	the	DT
cord-321868-xk4yuibj	360	5	frameshift	frameshift	NN
cord-321868-xk4yuibj	360	6	site	site	NN
cord-321868-xk4yuibj	360	7	indicates	indicate	VBZ
cord-321868-xk4yuibj	360	8	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	360	9	at	at	IN
cord-321868-xk4yuibj	360	10	the	the	DT
cord-321868-xk4yuibj	360	11	CUU	CUU	NNP
cord-321868-xk4yuibj	360	12	codon	codon	NN
cord-321868-xk4yuibj	360	13	,	,	,
cord-321868-xk4yuibj	360	14	eliminating	eliminate	VBG
cord-321868-xk4yuibj	360	15	the	the	DT
cord-321868-xk4yuibj	360	16	simultaneous	simultaneous	JJ
cord-321868-xk4yuibj	360	17	-	-	HYPH
cord-321868-xk4yuibj	360	18	slippage	slippage	NN
cord-321868-xk4yuibj	360	19	model	model	NN
cord-321868-xk4yuibj	360	20	of	of	IN
cord-321868-xk4yuibj	360	21	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	360	22	seen	see	VBN
cord-321868-xk4yuibj	360	23	in	in	IN
cord-321868-xk4yuibj	360	24	retroviruses	retrovirus	NNS
cord-321868-xk4yuibj	360	25	.	.	.
cord-321868-xk4yuibj	361	1	Overproduction	overproduction	NN
cord-321868-xk4yuibj	361	2	of	of	IN
cord-321868-xk4yuibj	361	3	tRNA$u	trna$u	NN
cord-321868-xk4yuibj	361	4	decreases	decrease	NNS
cord-321868-xk4yuibj	361	5	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	361	6	approximately	approximately	RB
cord-321868-xk4yuibj	361	7	43-fold	43-fold	CD
cord-321868-xk4yuibj	361	8	,	,	,
cord-321868-xk4yuibj	361	9	presumably	presumably	RB
cord-321868-xk4yuibj	361	10	by	by	IN
cord-321868-xk4yuibj	361	11	eliminating	eliminate	VBG
cord-321868-xk4yuibj	361	12	the	the	DT
cord-321868-xk4yuibj	361	13	translational	translational	JJ
cord-321868-xk4yuibj	361	14	pause	pause	NN
cord-321868-xk4yuibj	361	15	at	at	IN
cord-321868-xk4yuibj	361	16	the	the	DT
cord-321868-xk4yuibj	361	17	AGG	agg	NN
cord-321868-xk4yuibj	361	18	codon	codon	NN
cord-321868-xk4yuibj	361	19	.	.	.
cord-321868-xk4yuibj	362	1	Since	since	IN
cord-321868-xk4yuibj	362	2	tRNA	tRNA	NNP
cord-321868-xk4yuibj	362	3	'	'	POS
cord-321868-xk4yuibj	362	4	&	&	CC
cord-321868-xk4yuibj	362	5	is	be	VBZ
cord-321868-xk4yuibj	362	6	now	now	RB
cord-321868-xk4yuibj	362	7	abundant	abundant	JJ
cord-321868-xk4yuibj	362	8	in	in	IN
cord-321868-xk4yuibj	362	9	this	this	DT
cord-321868-xk4yuibj	362	10	background	background	NN
cord-321868-xk4yuibj	362	11	,	,	,
cord-321868-xk4yuibj	362	12	translation	translation	NN
cord-321868-xk4yuibj	362	13	continues	continue	VBZ
cord-321868-xk4yuibj	362	14	in	in	IN
cord-321868-xk4yuibj	362	15	the	the	DT
cord-321868-xk4yuibj	362	16	0	0	CD
cord-321868-xk4yuibj	362	17	frame	frame	NN
cord-321868-xk4yuibj	362	18	and	and	CC
cord-321868-xk4yuibj	362	19	terminates	terminate	VBZ
cord-321868-xk4yuibj	362	20	immediately	immediately	RB
cord-321868-xk4yuibj	362	21	downstream	downstream	JJ
cord-321868-xk4yuibj	362	22	.	.	.
cord-321868-xk4yuibj	363	1	This	this	DT
cord-321868-xk4yuibj	363	2	suggests	suggest	VBZ
cord-321868-xk4yuibj	363	3	that	that	IN
cord-321868-xk4yuibj	363	4	a	a	DT
cord-321868-xk4yuibj	363	5	translational	translational	JJ
cord-321868-xk4yuibj	363	6	pause	pause	NN
cord-321868-xk4yuibj	363	7	is	be	VBZ
cord-321868-xk4yuibj	363	8	an	an	DT
cord-321868-xk4yuibj	363	9	essential	essential	JJ
cord-321868-xk4yuibj	363	10	component	component	NN
cord-321868-xk4yuibj	363	11	of	of	IN
cord-321868-xk4yuibj	363	12	the	the	DT
cord-321868-xk4yuibj	363	13	frameshift	frameshift	NN
cord-321868-xk4yuibj	363	14	event	event	NN
cord-321868-xk4yuibj	363	15	in	in	IN
cord-321868-xk4yuibj	363	16	Ty	Ty	NNP
cord-321868-xk4yuibj	363	17	as	as	IN
cord-321868-xk4yuibj	363	18	it	-PRON-	PRP
cord-321868-xk4yuibj	363	19	seems	seem	VBZ
cord-321868-xk4yuibj	363	20	to	to	TO
cord-321868-xk4yuibj	363	21	be	be	VB
cord-321868-xk4yuibj	363	22	in	in	IN
cord-321868-xk4yuibj	363	23	other	other	JJ
cord-321868-xk4yuibj	363	24	systems	system	NNS
cord-321868-xk4yuibj	363	25	.	.	.
cord-321868-xk4yuibj	364	1	Significantly	significantly	RB
cord-321868-xk4yuibj	364	2	,	,	,
cord-321868-xk4yuibj	364	3	a	a	DT
cord-321868-xk4yuibj	364	4	high	high	JJ
cord-321868-xk4yuibj	364	5	copy	copy	NN
cord-321868-xk4yuibj	364	6	number	number	NN
cord-321868-xk4yuibj	364	7	suppressor	suppressor	NN
cord-321868-xk4yuibj	364	8	of	of	IN
cord-321868-xk4yuibj	364	9	Ty	ty	JJ
cord-321868-xk4yuibj	364	10	transposition	transposition	NN
cord-321868-xk4yuibj	364	11	maps	map	NNS
cord-321868-xk4yuibj	364	12	to	to	IN
cord-321868-xk4yuibj	364	13	the	the	DT
cord-321868-xk4yuibj	364	14	tRNA$	trna$	NN
cord-321868-xk4yuibj	364	15	gene	gene	NN
cord-321868-xk4yuibj	364	16	,	,	,
cord-321868-xk4yuibj	364	17	a	a	DT
cord-321868-xk4yuibj	364	18	result	result	NN
cord-321868-xk4yuibj	364	19	that	that	WDT
cord-321868-xk4yuibj	364	20	directly	directly	RB
cord-321868-xk4yuibj	364	21	supports	support	VBZ
cord-321868-xk4yuibj	364	22	the	the	DT
cord-321868-xk4yuibj	364	23	importance	importance	NN
cord-321868-xk4yuibj	364	24	of	of	IN
cord-321868-xk4yuibj	364	25	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	364	26	in	in	IN
cord-321868-xk4yuibj	364	27	the	the	DT
cord-321868-xk4yuibj	364	28	expression	expression	NN
cord-321868-xk4yuibj	364	29	of	of	IN
cord-321868-xk4yuibj	364	30	the	the	DT
cord-321868-xk4yuibj	364	31	p	p	NN
cord-321868-xk4yuibj	364	32	/	/	SYM
cord-321868-xk4yuibj	364	33	B	b	NN
cord-321868-xk4yuibj	364	34	gene	gene	NN
cord-321868-xk4yuibj	364	35	and	and	CC
cord-321868-xk4yuibj	364	36	hence	hence	RB
cord-321868-xk4yuibj	364	37	in	in	IN
cord-321868-xk4yuibj	364	38	transposition	transposition	NN
cord-321868-xk4yuibj	364	39	(	(	-LRB-
cord-321868-xk4yuibj	364	40	H.	H.	NNP
cord-321868-xk4yuibj	364	41	Xu	Xu	NNP
cord-321868-xk4yuibj	364	42	and	and	CC
cord-321868-xk4yuibj	364	43	J.	J.	NNP
cord-321868-xk4yuibj	364	44	D.	D.	NNP
cord-321868-xk4yuibj	364	45	Boeke	Boeke	NNP
cord-321868-xk4yuibj	364	46	,	,	,
cord-321868-xk4yuibj	364	47	personal	personal	JJ
cord-321868-xk4yuibj	364	48	communication	communication	NN
cord-321868-xk4yuibj	364	49	)	)	-RRB-
cord-321868-xk4yuibj	364	50	.	.	.
cord-321868-xk4yuibj	365	1	A	a	DT
cord-321868-xk4yuibj	365	2	second	second	JJ
cord-321868-xk4yuibj	365	3	result	result	NN
cord-321868-xk4yuibj	365	4	implicates	implicate	VBZ
cord-321868-xk4yuibj	365	5	tRNA$o	trna$o	XX
cord-321868-xk4yuibj	365	6	as	as	IN
cord-321868-xk4yuibj	365	7	the	the	DT
cord-321868-xk4yuibj	365	8	slippery	slippery	JJ
cord-321868-xk4yuibj	365	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	365	10	.	.	.
cord-321868-xk4yuibj	366	1	Since	since	IN
cord-321868-xk4yuibj	366	2	this	this	DT
cord-321868-xk4yuibj	366	3	tRNA	trna	NN
cord-321868-xk4yuibj	366	4	may	may	MD
cord-321868-xk4yuibj	366	5	be	be	VB
cord-321868-xk4yuibj	366	6	the	the	DT
cord-321868-xk4yuibj	366	7	only	only	JJ
cord-321868-xk4yuibj	366	8	tRNA	trna	NN
cord-321868-xk4yuibj	366	9	that	that	WDT
cord-321868-xk4yuibj	366	10	can	can	MD
cord-321868-xk4yuibj	366	11	decode	decode	VB
cord-321868-xk4yuibj	366	12	CUU	CUU	NNP
cord-321868-xk4yuibj	366	13	,	,	,
cord-321868-xk4yuibj	366	14	we	-PRON-	PRP
cord-321868-xk4yuibj	366	15	reasoned	reason	VBD
cord-321868-xk4yuibj	366	16	that	that	IN
cord-321868-xk4yuibj	366	17	overproduction	overproduction	NN
cord-321868-xk4yuibj	366	18	of	of	IN
cord-321868-xk4yuibj	366	19	a	a	DT
cord-321868-xk4yuibj	366	20	second	second	JJ
cord-321868-xk4yuibj	366	21	tRNA	trna	NN
cord-321868-xk4yuibj	366	22	that	that	WDT
cord-321868-xk4yuibj	366	23	decodes	decode	VBZ
cord-321868-xk4yuibj	366	24	CUU	CUU	NNP
cord-321868-xk4yuibj	366	25	exclusively	exclusively	RB
cord-321868-xk4yuibj	366	26	would	would	MD
cord-321868-xk4yuibj	366	27	compete	compete	VB
cord-321868-xk4yuibj	366	28	with	with	IN
cord-321868-xk4yuibj	366	29	tRNA/-	tRNA/-	NNP
cord-321868-xk4yuibj	366	30	&	&	CC
cord-321868-xk4yuibj	366	31	and	and	CC
cord-321868-xk4yuibj	366	32	reduce	reduce	VB
cord-321868-xk4yuibj	366	33	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	366	34	.	.	.
cord-321868-xk4yuibj	367	1	This	this	DT
cord-321868-xk4yuibj	367	2	second	second	JJ
cord-321868-xk4yuibj	367	3	tRNA	trna	NN
cord-321868-xk4yuibj	367	4	would	would	MD
cord-321868-xk4yuibj	367	5	not	not	RB
cord-321868-xk4yuibj	367	6	be	be	VB
cord-321868-xk4yuibj	367	7	expected	expect	VBN
cord-321868-xk4yuibj	367	8	The	the	DT
cord-321868-xk4yuibj	367	9	first	first	JJ
cord-321868-xk4yuibj	367	10	step	step	NN
cord-321868-xk4yuibj	367	11	necessitates	necessitate	VBZ
cord-321868-xk4yuibj	367	12	recognition	recognition	NN
cord-321868-xk4yuibj	367	13	of	of	IN
cord-321868-xk4yuibj	367	14	the	the	DT
cord-321868-xk4yuibj	367	15	CUU	CUU	NNP
cord-321868-xk4yuibj	367	16	codon	codon	NN
cord-321868-xk4yuibj	367	17	by	by	IN
cord-321868-xk4yuibj	367	18	tRNA	tRNA	NNP
cord-321868-xk4yuibj	367	19	&	&	CC
cord-321868-xk4yuibj	367	20	.	.	.
cord-321868-xk4yuibj	368	1	Owing	owe	VBG
cord-321868-xk4yuibj	368	2	to	to	IN
cord-321868-xk4yuibj	368	3	the	the	DT
cord-321868-xk4yuibj	368	4	low	low	JJ
cord-321868-xk4yuibj	368	5	availability	availability	NN
cord-321868-xk4yuibj	368	6	of	of	IN
cord-321868-xk4yuibj	368	7	tRNA	tRNA	NNP
cord-321868-xk4yuibj	368	8	'	'	POS
cord-321868-xk4yuibj	368	9	&	&	CC
cord-321868-xk4yuibj	368	10	,	,	,
cord-321868-xk4yuibj	368	11	a	a	DT
cord-321868-xk4yuibj	368	12	translational	translational	JJ
cord-321868-xk4yuibj	368	13	pause	pause	NN
cord-321868-xk4yuibj	368	14	at	at	IN
cord-321868-xk4yuibj	368	15	the	the	DT
cord-321868-xk4yuibj	368	16	AGG	agg	NN
cord-321868-xk4yuibj	368	17	codon	codon	NN
cord-321868-xk4yuibj	368	18	allows	allow	VBZ
cord-321868-xk4yuibj	368	19	time	time	NN
cord-321868-xk4yuibj	368	20	for	for	IN
cord-321868-xk4yuibj	368	21	a	a	DT
cord-321868-xk4yuibj	368	22	frameshift	frameshift	NN
cord-321868-xk4yuibj	368	23	to	to	TO
cord-321868-xk4yuibj	368	24	occur	occur	VB
cord-321868-xk4yuibj	368	25	at	at	IN
cord-321868-xk4yuibj	368	26	steo	steo	NN
cord-321868-xk4yuibj	368	27	2	2	CD
cord-321868-xk4yuibj	368	28	.	.	.
cord-321868-xk4yuibj	369	1	The	the	DT
cord-321868-xk4yuibj	369	2	commitment	commitment	NN
cord-321868-xk4yuibj	369	3	to	to	IN
cord-321868-xk4yuibj	369	4	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	369	5	occurs	occur	VBZ
cord-321868-xk4yuibj	369	6	at	at	IN
cord-321868-xk4yuibj	369	7	step	step	NN
cord-321868-xk4yuibj	369	8	3	3	CD
cord-321868-xk4yuibj	369	9	when	when	WRB
cord-321868-xk4yuibj	369	10	the	the	DT
cord-321868-xk4yuibj	369	11	next	next	JJ
cord-321868-xk4yuibj	369	12	+1	+1	HYPH
cord-321868-xk4yuibj	369	13	frame	frame	NN
cord-321868-xk4yuibj	369	14	codon	codon	NN
cord-321868-xk4yuibj	369	15	is	be	VBZ
cord-321868-xk4yuibj	369	16	recognized	recognize	VBN
cord-321868-xk4yuibj	369	17	by	by	IN
cord-321868-xk4yuibj	369	18	its	-PRON-	PRP$
cord-321868-xk4yuibj	369	19	cognate	cognate	JJ
cord-321868-xk4yuibj	369	20	tRNA	tRNA	NNP
cord-321868-xk4yuibj	369	21	.	.	.
cord-321868-xk4yuibj	369	22	to	to	TO
cord-321868-xk4yuibj	369	23	be	be	VB
cord-321868-xk4yuibj	369	24	able	able	JJ
cord-321868-xk4yuibj	369	25	to	to	TO
cord-321868-xk4yuibj	369	26	slip	slip	VB
cord-321868-xk4yuibj	369	27	onto	onto	IN
cord-321868-xk4yuibj	369	28	UUA	UUA	NNP
cord-321868-xk4yuibj	369	29	.	.	.
cord-321868-xk4yuibj	370	1	Changing	change	VBG
cord-321868-xk4yuibj	370	2	the	the	DT
cord-321868-xk4yuibj	370	3	anticodon	anticodon	NN
cord-321868-xk4yuibj	370	4	of	of	IN
cord-321868-xk4yuibj	370	5	tRNA	tRNA	NNP
cord-321868-xk4yuibj	370	6	&	&	CC
cord-321868-xk4yuibj	370	7	,	,	,
cord-321868-xk4yuibj	370	8	to	to	TO
cord-321868-xk4yuibj	370	9	create	create	VB
cord-321868-xk4yuibj	370	10	tRNA	tRNA	NNP
cord-321868-xk4yuibj	370	11	&	&	CC
cord-321868-xk4yuibj	370	12	and	and	CC
cord-321868-xk4yuibj	370	13	overproducing	overproduce	VBG
cord-321868-xk4yuibj	370	14	this	this	DT
cord-321868-xk4yuibj	370	15	tRNA	tRNA	NNP
cord-321868-xk4yuibj	370	16	results	result	VBZ
cord-321868-xk4yuibj	370	17	in	in	IN
cord-321868-xk4yuibj	370	18	a	a	DT
cord-321868-xk4yuibj	370	19	43-fold	43-fold	CD
cord-321868-xk4yuibj	370	20	inhibition	inhibition	NN
cord-321868-xk4yuibj	370	21	of	of	IN
cord-321868-xk4yuibj	370	22	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	370	23	.	.	.
cord-321868-xk4yuibj	371	1	Clearly	clearly	RB
cord-321868-xk4yuibj	371	2	,	,	,
cord-321868-xk4yuibj	371	3	this	this	DT
cord-321868-xk4yuibj	371	4	result	result	NN
cord-321868-xk4yuibj	371	5	demonstrates	demonstrate	VBZ
cord-321868-xk4yuibj	371	6	the	the	DT
cord-321868-xk4yuibj	371	7	importance	importance	NN
cord-321868-xk4yuibj	371	8	of	of	IN
cord-321868-xk4yuibj	371	9	tRNAfze	tRNAfze	NNP
cord-321868-xk4yuibj	371	10	in	in	IN
cord-321868-xk4yuibj	371	11	the	the	DT
cord-321868-xk4yuibj	371	12	frameshift	frameshift	NN
cord-321868-xk4yuibj	371	13	event	event	NN
cord-321868-xk4yuibj	371	14	.	.	.
cord-321868-xk4yuibj	372	1	As	as	IN
cord-321868-xk4yuibj	372	2	indicated	indicate	VBN
cord-321868-xk4yuibj	372	3	by	by	IN
cord-321868-xk4yuibj	372	4	the	the	DT
cord-321868-xk4yuibj	372	5	missense	missense	NN
cord-321868-xk4yuibj	372	6	mutagenesis	mutagenesis	NN
cord-321868-xk4yuibj	372	7	data	datum	NNS
cord-321868-xk4yuibj	372	8	,	,	,
cord-321868-xk4yuibj	372	9	some	some	DT
cord-321868-xk4yuibj	372	10	changes	change	NNS
cord-321868-xk4yuibj	372	11	in	in	IN
cord-321868-xk4yuibj	372	12	the	the	DT
cord-321868-xk4yuibj	372	13	7	7	CD
cord-321868-xk4yuibj	372	14	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	372	15	sequence	sequence	NN
cord-321868-xk4yuibj	372	16	allow	allow	VBP
cord-321868-xk4yuibj	372	17	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	372	18	at	at	IN
cord-321868-xk4yuibj	372	19	low	low	JJ
cord-321868-xk4yuibj	372	20	levels	level	NNS
cord-321868-xk4yuibj	372	21	.	.	.
cord-321868-xk4yuibj	373	1	These	these	DT
cord-321868-xk4yuibj	373	2	changes	change	NNS
cord-321868-xk4yuibj	373	3	allow	allow	VBP
cord-321868-xk4yuibj	373	4	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	373	5	at	at	IN
cord-321868-xk4yuibj	373	6	levels	level	NNS
cord-321868-xk4yuibj	373	7	of	of	IN
cord-321868-xk4yuibj	373	8	approximately	approximately	RB
cord-321868-xk4yuibj	373	9	20-to	20-to	CD
cord-321868-xk4yuibj	373	10	30-fold	30-fold	RB
cord-321868-xk4yuibj	373	11	below	below	IN
cord-321868-xk4yuibj	373	12	that	that	DT
cord-321868-xk4yuibj	373	13	of	of	IN
cord-321868-xk4yuibj	373	14	the	the	DT
cord-321868-xk4yuibj	373	15	wild	wild	JJ
cord-321868-xk4yuibj	373	16	-	-	HYPH
cord-321868-xk4yuibj	373	17	type	type	NN
cord-321868-xk4yuibj	373	18	sequence	sequence	NN
cord-321868-xk4yuibj	373	19	.	.	.
cord-321868-xk4yuibj	374	1	It	-PRON-	PRP
cord-321868-xk4yuibj	374	2	is	be	VBZ
cord-321868-xk4yuibj	374	3	difficult	difficult	JJ
cord-321868-xk4yuibj	374	4	to	to	TO
cord-321868-xk4yuibj	374	5	ascertain	ascertain	VB
cord-321868-xk4yuibj	374	6	why	why	WRB
cord-321868-xk4yuibj	374	7	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	374	8	can	can	MD
cord-321868-xk4yuibj	374	9	occur	occur	VB
cord-321868-xk4yuibj	374	10	in	in	IN
cord-321868-xk4yuibj	374	11	some	some	DT
cord-321868-xk4yuibj	374	12	of	of	IN
cord-321868-xk4yuibj	374	13	these	these	DT
cord-321868-xk4yuibj	374	14	cases	case	NNS
cord-321868-xk4yuibj	374	15	;	;	:
cord-321868-xk4yuibj	374	16	however	however	RB
cord-321868-xk4yuibj	374	17	,	,	,
cord-321868-xk4yuibj	374	18	the	the	DT
cord-321868-xk4yuibj	374	19	two	two	CD
cord-321868-xk4yuibj	374	20	cases	case	NNS
cord-321868-xk4yuibj	374	21	showing	show	VBG
cord-321868-xk4yuibj	374	22	the	the	DT
cord-321868-xk4yuibj	374	23	highest	high	JJS
cord-321868-xk4yuibj	374	24	levels	level	NNS
cord-321868-xk4yuibj	374	25	of	of	IN
cord-321868-xk4yuibj	374	26	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	374	27	may	may	MD
cord-321868-xk4yuibj	374	28	share	share	VB
cord-321868-xk4yuibj	374	29	some	some	DT
cord-321868-xk4yuibj	374	30	features	feature	NNS
cord-321868-xk4yuibj	374	31	with	with	IN
cord-321868-xk4yuibj	374	32	the	the	DT
cord-321868-xk4yuibj	374	33	wild	wild	JJ
cord-321868-xk4yuibj	374	34	-	-	HYPH
cord-321868-xk4yuibj	374	35	type	type	NN
cord-321868-xk4yuibj	374	36	sequence	sequence	NN
cord-321868-xk4yuibj	374	37	.	.	.
cord-321868-xk4yuibj	375	1	The	the	DT
cord-321868-xk4yuibj	375	2	A	a	NN
cord-321868-xk4yuibj	375	3	to	to	IN
cord-321868-xk4yuibj	375	4	C	C	NNP
cord-321868-xk4yuibj	375	5	change	change	NN
cord-321868-xk4yuibj	375	6	at	at	IN
cord-321868-xk4yuibj	375	7	the	the	DT
cord-321868-xk4yuibj	375	8	first	first	JJ
cord-321868-xk4yuibj	375	9	position	position	NN
cord-321868-xk4yuibj	375	10	of	of	IN
cord-321868-xk4yuibj	375	11	the	the	DT
cord-321868-xk4yuibj	375	12	second	second	JJ
cord-321868-xk4yuibj	375	13	codon	codon	NN
cord-321868-xk4yuibj	375	14	produces	produce	VBZ
cord-321868-xk4yuibj	375	15	a	a	DT
cord-321868-xk4yuibj	375	16	CGG	CGG	NNP
cord-321868-xk4yuibj	375	17	arginine	arginine	NN
cord-321868-xk4yuibj	375	18	codon	codon	NN
cord-321868-xk4yuibj	375	19	in	in	IN
cord-321868-xk4yuibj	375	20	the	the	DT
cord-321868-xk4yuibj	375	21	0	0	CD
cord-321868-xk4yuibj	375	22	frame	frame	NN
cord-321868-xk4yuibj	375	23	and	and	CC
cord-321868-xk4yuibj	375	24	a	a	DT
cord-321868-xk4yuibj	375	25	ULJC	ULJC	NNP
cord-321868-xk4yuibj	375	26	phenylalanine	phenylalanine	NN
cord-321868-xk4yuibj	375	27	codon	codon	NN
cord-321868-xk4yuibj	375	28	in	in	IN
cord-321868-xk4yuibj	375	29	the	the	DT
cord-321868-xk4yuibj	375	30	+	+	SYM
cord-321868-xk4yuibj	375	31	l	l	NN
cord-321868-xk4yuibj	375	32	frame	frame	NN
cord-321868-xk4yuibj	375	33	.	.	.
cord-321868-xk4yuibj	376	1	CGG	CGG	NNP
cord-321868-xk4yuibj	376	2	is	be	VBZ
cord-321868-xk4yuibj	376	3	a	a	DT
cord-321868-xk4yuibj	376	4	codon	codon	NN
cord-321868-xk4yuibj	376	5	recognized	recognize	VBN
cord-321868-xk4yuibj	376	6	by	by	IN
cord-321868-xk4yuibj	376	7	a	a	DT
cord-321868-xk4yuibj	376	8	rare	rare	JJ
cord-321868-xk4yuibj	376	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	376	10	,	,	,
cord-321868-xk4yuibj	376	11	tRNA	tRNA	NNP
cord-321868-xk4yuibj	376	12	&	&	CC
cord-321868-xk4yuibj	376	13	.	.	.
cord-321868-xk4yuibj	377	1	A	a	DT
cord-321868-xk4yuibj	377	2	possible	possible	JJ
cord-321868-xk4yuibj	377	3	reason	reason	NN
cord-321868-xk4yuibj	377	4	why	why	WRB
cord-321868-xk4yuibj	377	5	this	this	DT
cord-321868-xk4yuibj	377	6	sequence	sequence	NN
cord-321868-xk4yuibj	377	7	does	do	VBZ
cord-321868-xk4yuibj	377	8	not	not	RB
cord-321868-xk4yuibj	377	9	support	support	VB
cord-321868-xk4yuibj	377	10	higher	high	JJR
cord-321868-xk4yuibj	377	11	levels	level	NNS
cord-321868-xk4yuibj	377	12	of	of	IN
cord-321868-xk4yuibj	377	13	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	377	14	is	be	VBZ
cord-321868-xk4yuibj	377	15	seen	see	VBN
cord-321868-xk4yuibj	377	16	in	in	IN
cord-321868-xk4yuibj	377	17	the	the	DT
cord-321868-xk4yuibj	377	18	codon	codon	NN
cord-321868-xk4yuibj	377	19	usage	usage	NN
cord-321868-xk4yuibj	377	20	pattern	pattern	NN
cord-321868-xk4yuibj	377	21	for	for	IN
cord-321868-xk4yuibj	377	22	CGG	CGG	NNP
cord-321868-xk4yuibj	377	23	.	.	.
cord-321868-xk4yuibj	378	1	CGG	CGG	NNP
cord-321868-xk4yuibj	378	2	appears	appear	VBZ
cord-321868-xk4yuibj	378	3	at	at	IN
cord-321868-xk4yuibj	378	4	a	a	DT
cord-321868-xk4yuibj	378	5	level	level	NN
cord-321868-xk4yuibj	378	6	7-fold	7-fold	CD
cord-321868-xk4yuibj	378	7	below	below	IN
cord-321868-xk4yuibj	378	8	that	that	DT
cord-321868-xk4yuibj	378	9	of	of	IN
cord-321868-xk4yuibj	378	10	AGG	agg	NN
cord-321868-xk4yuibj	378	11	in	in	IN
cord-321868-xk4yuibj	378	12	yeast	yeast	NN
cord-321868-xk4yuibj	378	13	genes	gene	NNS
cord-321868-xk4yuibj	378	14	(	(	-LRB-
cord-321868-xk4yuibj	378	15	Aota	Aota	NNP
cord-321868-xk4yuibj	378	16	et	et	FW
cord-321868-xk4yuibj	378	17	al	al	NNP
cord-321868-xk4yuibj	378	18	.	.	NNP
cord-321868-xk4yuibj	378	19	,	,	,
cord-321868-xk4yuibj	378	20	1988	1988	CD
cord-321868-xk4yuibj	378	21	)	)	-RRB-
cord-321868-xk4yuibj	378	22	.	.	.
cord-321868-xk4yuibj	379	1	The	the	DT
cord-321868-xk4yuibj	379	2	lower	low	JJR
cord-321868-xk4yuibj	379	3	demand	demand	NN
cord-321868-xk4yuibj	379	4	for	for	IN
cord-321868-xk4yuibj	379	5	tRNA$zo	tRNA$zo	NNP
cord-321868-xk4yuibj	379	6	could	could	MD
cord-321868-xk4yuibj	379	7	reduce	reduce	VB
cord-321868-xk4yuibj	379	8	the	the	DT
cord-321868-xk4yuibj	379	9	length	length	NN
cord-321868-xk4yuibj	379	10	of	of	IN
cord-321868-xk4yuibj	379	11	the	the	DT
cord-321868-xk4yuibj	379	12	translational	translational	JJ
cord-321868-xk4yuibj	379	13	pause	pause	NN
cord-321868-xk4yuibj	379	14	needed	need	VBN
cord-321868-xk4yuibj	379	15	for	for	IN
cord-321868-xk4yuibj	379	16	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	379	17	.	.	.
cord-321868-xk4yuibj	380	1	This	this	DT
cord-321868-xk4yuibj	380	2	should	should	MD
cord-321868-xk4yuibj	380	3	result	result	VB
cord-321868-xk4yuibj	380	4	in	in	IN
cord-321868-xk4yuibj	380	5	a	a	DT
cord-321868-xk4yuibj	380	6	lower	low	JJR
cord-321868-xk4yuibj	380	7	proportion	proportion	NN
cord-321868-xk4yuibj	380	8	of	of	IN
cord-321868-xk4yuibj	380	9	frameshift	frameshift	NN
cord-321868-xk4yuibj	380	10	events	event	NNS
cord-321868-xk4yuibj	380	11	occurring	occur	VBG
cord-321868-xk4yuibj	380	12	before	before	IN
cord-321868-xk4yuibj	380	13	translation	translation	NN
cord-321868-xk4yuibj	380	14	continues	continue	VBZ
cord-321868-xk4yuibj	380	15	by	by	IN
cord-321868-xk4yuibj	380	16	insertion	insertion	NN
cord-321868-xk4yuibj	380	17	of	of	IN
cord-321868-xk4yuibj	380	18	arginine	arginine	NN
cord-321868-xk4yuibj	380	19	at	at	IN
cord-321868-xk4yuibj	380	20	the	the	DT
cord-321868-xk4yuibj	380	21	in	in	IN
cord-321868-xk4yuibj	380	22	-	-	HYPH
cord-321868-xk4yuibj	380	23	frame	frame	NN
cord-321868-xk4yuibj	380	24	CGG	CGG	NNP
cord-321868-xk4yuibj	380	25	codon	codon	NN
cord-321868-xk4yuibj	380	26	.	.	.
cord-321868-xk4yuibj	381	1	The	the	DT
cord-321868-xk4yuibj	381	2	G	g	NN
cord-321868-xk4yuibj	381	3	to	to	TO
cord-321868-xk4yuibj	381	4	U	u	PRP
cord-321868-xk4yuibj	381	5	change	change	NN
cord-321868-xk4yuibj	381	6	at	at	IN
cord-321868-xk4yuibj	381	7	the	the	DT
cord-321868-xk4yuibj	381	8	third	third	JJ
cord-321868-xk4yuibj	381	9	position	position	NN
cord-321868-xk4yuibj	381	10	of	of	IN
cord-321868-xk4yuibj	381	11	the	the	DT
cord-321868-xk4yuibj	381	12	second	second	JJ
cord-321868-xk4yuibj	381	13	codon	codon	NN
cord-321868-xk4yuibj	381	14	retains	retain	VBZ
cord-321868-xk4yuibj	381	15	the	the	DT
cord-321868-xk4yuibj	381	16	CUU	CUU	NNP
cord-321868-xk4yuibj	381	17	to	to	IN
cord-321868-xk4yuibj	381	18	UUA	uua	VB
cord-321868-xk4yuibj	381	19	slippery	slippery	JJ
cord-321868-xk4yuibj	381	20	sequence	sequence	NN
cord-321868-xk4yuibj	381	21	but	but	CC
cord-321868-xk4yuibj	381	22	changes	change	VBZ
cord-321868-xk4yuibj	381	23	the	the	DT
cord-321868-xk4yuibj	381	24	AGG	agg	NN
cord-321868-xk4yuibj	381	25	-	-	HYPH
cord-321868-xk4yuibj	381	26	Arg	arg	NN
cord-321868-xk4yuibj	381	27	codon	codon	NN
cord-321868-xk4yuibj	381	28	to	to	IN
cord-321868-xk4yuibj	381	29	AGU	AGU	NNP
cord-321868-xk4yuibj	381	30	-	-	HYPH
cord-321868-xk4yuibj	381	31	Ser	Ser	NNP
cord-321868-xk4yuibj	381	32	.	.	.
cord-321868-xk4yuibj	382	1	AGU	AGU	NNP
cord-321868-xk4yuibj	382	2	must	must	MD
cord-321868-xk4yuibj	382	3	also	also	RB
cord-321868-xk4yuibj	382	4	allow	allow	VB
cord-321868-xk4yuibj	382	5	a	a	DT
cord-321868-xk4yuibj	382	6	shorter	short	JJR
cord-321868-xk4yuibj	382	7	pause	pause	NN
cord-321868-xk4yuibj	382	8	;	;	:
cord-321868-xk4yuibj	382	9	the	the	DT
cord-321868-xk4yuibj	382	10	tRNA	trna	NN
cord-321868-xk4yuibj	382	11	that	that	WDT
cord-321868-xk4yuibj	382	12	decodes	decode	VBZ
cord-321868-xk4yuibj	382	13	it	-PRON-	PRP
cord-321868-xk4yuibj	382	14	has	have	VBZ
cord-321868-xk4yuibj	382	15	not	not	RB
cord-321868-xk4yuibj	382	16	been	be	VBN
cord-321868-xk4yuibj	382	17	identified	identify	VBN
cord-321868-xk4yuibj	382	18	,	,	,
cord-321868-xk4yuibj	382	19	so	so	IN
cord-321868-xk4yuibj	382	20	we	-PRON-	PRP
cord-321868-xk4yuibj	382	21	do	do	VBP
cord-321868-xk4yuibj	382	22	not	not	RB
cord-321868-xk4yuibj	382	23	know	know	VB
cord-321868-xk4yuibj	382	24	if	if	IN
cord-321868-xk4yuibj	382	25	it	-PRON-	PRP
cord-321868-xk4yuibj	382	26	is	be	VBZ
cord-321868-xk4yuibj	382	27	a	a	DT
cord-321868-xk4yuibj	382	28	rare	rare	JJ
cord-321868-xk4yuibj	382	29	or	or	CC
cord-321868-xk4yuibj	382	30	abundant	abundant	JJ
cord-321868-xk4yuibj	382	31	tRNA	trna	NN
cord-321868-xk4yuibj	382	32	.	.	.
cord-321868-xk4yuibj	383	1	Thus	thus	RB
cord-321868-xk4yuibj	383	2	far	far	RB
cord-321868-xk4yuibj	383	3	,	,	,
cord-321868-xk4yuibj	383	4	attempts	attempt	VBZ
cord-321868-xk4yuibj	383	5	to	to	TO
cord-321868-xk4yuibj	383	6	create	create	VB
cord-321868-xk4yuibj	383	7	a	a	DT
cord-321868-xk4yuibj	383	8	frameshift	frameshift	NN
cord-321868-xk4yuibj	383	9	site	site	NN
cord-321868-xk4yuibj	383	10	by	by	IN
cord-321868-xk4yuibj	383	11	replacing	replace	VBG
cord-321868-xk4yuibj	383	12	the	the	DT
cord-321868-xk4yuibj	383	13	AGO	AGO	NNP
cord-321868-xk4yuibj	383	14	codon	codon	NN
cord-321868-xk4yuibj	383	15	with	with	IN
cord-321868-xk4yuibj	383	16	other	other	JJ
cord-321868-xk4yuibj	383	17	codons	codon	NNS
cord-321868-xk4yuibj	383	18	recognized	recognize	VBN
cord-321868-xk4yuibj	383	19	by	by	IN
cord-321868-xk4yuibj	383	20	nonabundant	nonabundant	JJ
cord-321868-xk4yuibj	383	21	tRNAs	trna	NNS
cord-321868-xk4yuibj	383	22	have	have	VBP
cord-321868-xk4yuibj	383	23	failed	fail	VBN
cord-321868-xk4yuibj	383	24	.	.	.
cord-321868-xk4yuibj	384	1	An	an	DT
cord-321868-xk4yuibj	384	2	experiment	experiment	NN
cord-321868-xk4yuibj	384	3	that	that	WDT
cord-321868-xk4yuibj	384	4	definitively	definitively	RB
cord-321868-xk4yuibj	384	5	tests	test	VBZ
cord-321868-xk4yuibj	384	6	this	this	DT
cord-321868-xk4yuibj	384	7	hypothesis	hypothesis	NN
cord-321868-xk4yuibj	384	8	uses	use	VBZ
cord-321868-xk4yuibj	384	9	a	a	DT
cord-321868-xk4yuibj	384	10	family	family	NN
cord-321868-xk4yuibj	384	11	of	of	IN
cord-321868-xk4yuibj	384	12	strains	strain	NNS
cord-321868-xk4yuibj	384	13	retaining	retain	VBG
cord-321868-xk4yuibj	384	14	from	from	IN
cord-321868-xk4yuibj	384	15	eight	eight	CD
cord-321868-xk4yuibj	384	16	to	to	IN
cord-321868-xk4yuibj	384	17	only	only	RB
cord-321868-xk4yuibj	384	18	two	two	CD
cord-321868-xk4yuibj	384	19	of	of	IN
cord-321868-xk4yuibj	384	20	the	the	DT
cord-321868-xk4yuibj	384	21	tRNA$	tRNA$	NNP
cord-321868-xk4yuibj	384	22	&	&	CC
cord-321868-xk4yuibj	384	23	genes	gene	NNS
cord-321868-xk4yuibj	384	24	,	,	,
cord-321868-xk4yuibj	384	25	the	the	DT
cord-321868-xk4yuibj	384	26	expectation	expectation	NN
cord-321868-xk4yuibj	384	27	being	be	VBG
cord-321868-xk4yuibj	384	28	that	that	IN
cord-321868-xk4yuibj	384	29	when	when	WRB
cord-321868-xk4yuibj	384	30	the	the	DT
cord-321868-xk4yuibj	384	31	cell	cell	NN
cord-321868-xk4yuibj	384	32	is	be	VBZ
cord-321868-xk4yuibj	384	33	limited	limit	VBN
cord-321868-xk4yuibj	384	34	for	for	IN
cord-321868-xk4yuibj	384	35	tRNA	trna	NN
cord-321868-xk4yuibj	384	36	decoding	decode	VBG
cord-321868-xk4yuibj	384	37	the	the	DT
cord-321868-xk4yuibj	384	38	two	two	CD
cord-321868-xk4yuibj	384	39	tyrosine	tyrosine	NN
cord-321868-xk4yuibj	384	40	codons	codon	NNS
cord-321868-xk4yuibj	384	41	,	,	,
cord-321868-xk4yuibj	384	42	competition	competition	NN
cord-321868-xk4yuibj	384	43	for	for	IN
cord-321868-xk4yuibj	384	44	the	the	DT
cord-321868-xk4yuibj	384	45	aminoacyl	aminoacyl	NNP
cord-321868-xk4yuibj	384	46	-	-	HYPH
cord-321868-xk4yuibj	384	47	tRNA	tRNA	NNP
cord-321868-xk4yuibj	384	48	will	will	MD
cord-321868-xk4yuibj	384	49	be	be	VB
cord-321868-xk4yuibj	384	50	severe	severe	JJ
cord-321868-xk4yuibj	384	51	and	and	CC
cord-321868-xk4yuibj	384	52	a	a	DT
cord-321868-xk4yuibj	384	53	substantial	substantial	JJ
cord-321868-xk4yuibj	384	54	translational	translational	JJ
cord-321868-xk4yuibj	384	55	pause	pause	NN
cord-321868-xk4yuibj	384	56	should	should	MD
cord-321868-xk4yuibj	384	57	result	result	VB
cord-321868-xk4yuibj	384	58	.	.	.
cord-321868-xk4yuibj	385	1	The	the	DT
cord-321868-xk4yuibj	385	2	fact	fact	NN
cord-321868-xk4yuibj	385	3	that	that	IN
cord-321868-xk4yuibj	385	4	this	this	DT
cord-321868-xk4yuibj	385	5	,	,	,
cord-321868-xk4yuibj	385	6	too	too	RB
cord-321868-xk4yuibj	385	7	,	,	,
cord-321868-xk4yuibj	385	8	failed	fail	VBD
cord-321868-xk4yuibj	385	9	forces	force	NNS
cord-321868-xk4yuibj	385	10	us	-PRON-	PRP
cord-321868-xk4yuibj	385	11	to	to	TO
cord-321868-xk4yuibj	385	12	conclude	conclude	VB
cord-321868-xk4yuibj	385	13	either	either	CC
cord-321868-xk4yuibj	385	14	that	that	IN
cord-321868-xk4yuibj	385	15	competition	competition	NN
cord-321868-xk4yuibj	385	16	for	for	IN
cord-321868-xk4yuibj	385	17	the	the	DT
cord-321868-xk4yuibj	385	18	tRNA	tRNA	NNP
cord-321868-xk4yuibj	385	19	&	&	CC
cord-321868-xk4yuibj	385	20	,	,	,
cord-321868-xk4yuibj	385	21	is	be	VBZ
cord-321868-xk4yuibj	385	22	especially	especially	RB
cord-321868-xk4yuibj	385	23	severe	severe	JJ
cord-321868-xk4yuibj	385	24	or	or	CC
cord-321868-xk4yuibj	385	25	that	that	IN
cord-321868-xk4yuibj	385	26	the	the	DT
cord-321868-xk4yuibj	385	27	translational	translational	JJ
cord-321868-xk4yuibj	385	28	pause	pause	NN
cord-321868-xk4yuibj	385	29	induced	induce	VBN
cord-321868-xk4yuibj	385	30	by	by	IN
cord-321868-xk4yuibj	385	31	competition	competition	NN
cord-321868-xk4yuibj	385	32	for	for	IN
cord-321868-xk4yuibj	385	33	the	the	DT
cord-321868-xk4yuibj	385	34	tRNA	trna	NN
cord-321868-xk4yuibj	385	35	is	be	VBZ
cord-321868-xk4yuibj	385	36	not	not	RB
cord-321868-xk4yuibj	385	37	the	the	DT
cord-321868-xk4yuibj	385	38	only	only	JJ
cord-321868-xk4yuibj	385	39	function	function	NN
cord-321868-xk4yuibj	385	40	of	of	IN
cord-321868-xk4yuibj	385	41	the	the	DT
cord-321868-xk4yuibj	385	42	AGG	agg	NN
cord-321868-xk4yuibj	385	43	codon	codon	NN
cord-321868-xk4yuibj	385	44	,	,	,
cord-321868-xk4yuibj	385	45	the	the	DT
cord-321868-xk4yuibj	385	46	second	second	JJ
cord-321868-xk4yuibj	385	47	role	role	NN
cord-321868-xk4yuibj	385	48	not	not	RB
cord-321868-xk4yuibj	385	49	being	be	VBG
cord-321868-xk4yuibj	385	50	satisfied	satisfied	JJ
cord-321868-xk4yuibj	385	51	by	by	IN
cord-321868-xk4yuibj	385	52	the	the	DT
cord-321868-xk4yuibj	385	53	other	other	JJ
cord-321868-xk4yuibj	385	54	codons	codon	NNS
cord-321868-xk4yuibj	385	55	tested	test	VBN
cord-321868-xk4yuibj	385	56	.	.	.
cord-321868-xk4yuibj	386	1	A	a	DT
cord-321868-xk4yuibj	386	2	more	more	RBR
cord-321868-xk4yuibj	386	3	exhaustive	exhaustive	JJ
cord-321868-xk4yuibj	386	4	search	search	NN
cord-321868-xk4yuibj	386	5	for	for	IN
cord-321868-xk4yuibj	386	6	possible	possible	JJ
cord-321868-xk4yuibj	386	7	substitute	substitute	NN
cord-321868-xk4yuibj	386	8	"	"	``
cord-321868-xk4yuibj	386	9	pause	pause	NN
cord-321868-xk4yuibj	386	10	"	"	''
cord-321868-xk4yuibj	386	11	codons	codon	NNS
cord-321868-xk4yuibj	386	12	may	may	MD
cord-321868-xk4yuibj	386	13	determine	determine	VB
cord-321868-xk4yuibj	386	14	which	which	WDT
cord-321868-xk4yuibj	386	15	possibility	possibility	NN
cord-321868-xk4yuibj	386	16	is	be	VBZ
cord-321868-xk4yuibj	386	17	correct	correct	JJ
cord-321868-xk4yuibj	386	18	.	.	.
cord-321868-xk4yuibj	387	1	Remarkably	remarkably	RB
cord-321868-xk4yuibj	387	2	,	,	,
cord-321868-xk4yuibj	387	3	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	387	4	in	in	IN
cord-321868-xk4yuibj	387	5	Ty	Ty	NNP
cord-321868-xk4yuibj	387	6	elements	element	NNS
cord-321868-xk4yuibj	387	7	is	be	VBZ
cord-321868-xk4yuibj	387	8	inhibited	inhibit	VBN
cord-321868-xk4yuibj	387	9	by	by	IN
cord-321868-xk4yuibj	387	10	the	the	DT
cord-321868-xk4yuibj	387	11	proximity	proximity	NN
cord-321868-xk4yuibj	387	12	of	of	IN
cord-321868-xk4yuibj	387	13	the	the	DT
cord-321868-xk4yuibj	387	14	frameshift	frameshift	NN
cord-321868-xk4yuibj	387	15	site	site	NN
cord-321868-xk4yuibj	387	16	to	to	IN
cord-321868-xk4yuibj	387	17	the	the	DT
cord-321868-xk4yuibj	387	18	translational	translational	JJ
cord-321868-xk4yuibj	387	19	initiation	initiation	NN
cord-321868-xk4yuibj	387	20	codon	codon	NNP
cord-321868-xk4yuibj	387	21	.	.	.
cord-321868-xk4yuibj	388	1	This	this	DT
cord-321868-xk4yuibj	388	2	phenomenon	phenomenon	NN
cord-321868-xk4yuibj	388	3	was	be	VBD
cord-321868-xk4yuibj	388	4	first	first	RB
cord-321868-xk4yuibj	388	5	observed	observe	VBN
cord-321868-xk4yuibj	388	6	by	by	IN
cord-321868-xk4yuibj	388	7	placement	placement	NN
cord-321868-xk4yuibj	388	8	of	of	IN
cord-321868-xk4yuibj	388	9	the	the	DT
cord-321868-xk4yuibj	388	10	14	14	CD
cord-321868-xk4yuibj	388	11	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	388	12	frameshift	frameshift	NN
cord-321868-xk4yuibj	388	13	site	site	NN
cord-321868-xk4yuibj	388	14	within	within	IN
cord-321868-xk4yuibj	388	15	four	four	CD
cord-321868-xk4yuibj	388	16	codons	codon	NNS
cord-321868-xk4yuibj	388	17	of	of	IN
cord-321868-xk4yuibj	388	18	the	the	DT
cord-321868-xk4yuibj	388	19	initiation	initiation	NN
cord-321868-xk4yuibj	388	20	codon	codon	NN
cord-321868-xk4yuibj	388	21	of	of	IN
cord-321868-xk4yuibj	388	22	Ty2	ty2	CD
cord-321868-xk4yuibj	388	23	-	-	HYPH
cord-321868-xk4yuibj	388	24	917	917	CD
cord-321868-xk4yuibj	389	1	(	(	-LRB-
cord-321868-xk4yuibj	389	2	Clare	Clare	NNP
cord-321868-xk4yuibj	389	3	et	et	NNP
cord-321868-xk4yuibj	389	4	al	al	NNP
cord-321868-xk4yuibj	389	5	.	.	NNP
cord-321868-xk4yuibj	389	6	,	,	,
cord-321868-xk4yuibj	389	7	1988	1988	CD
cord-321868-xk4yuibj	389	8	)	)	-RRB-
cord-321868-xk4yuibj	389	9	.	.	.
cord-321868-xk4yuibj	390	1	Frameshifting	Frameshifting	NNP
cord-321868-xk4yuibj	390	2	was	be	VBD
cord-321868-xk4yuibj	390	3	completely	completely	RB
cord-321868-xk4yuibj	390	4	inhibited	inhibit	VBN
cord-321868-xk4yuibj	390	5	.	.	.
cord-321868-xk4yuibj	391	1	Similarly	similarly	RB
cord-321868-xk4yuibj	391	2	,	,	,
cord-321868-xk4yuibj	391	3	placement	placement	NN
cord-321868-xk4yuibj	391	4	of	of	IN
cord-321868-xk4yuibj	391	5	the	the	DT
cord-321868-xk4yuibj	391	6	site	site	NN
cord-321868-xk4yuibj	391	7	the	the	DT
cord-321868-xk4yuibj	391	8	same	same	JJ
cord-321868-xk4yuibj	391	9	distance	distance	NN
cord-321868-xk4yuibj	391	10	from	from	IN
cord-321868-xk4yuibj	391	11	the	the	DT
cord-321868-xk4yuibj	391	12	I-/MA	I-/MA	NNP
cord-321868-xk4yuibj	391	13	initiation	initiation	NN
cord-321868-xk4yuibj	391	14	codon	codon	NN
cord-321868-xk4yuibj	391	15	inhibits	inhibit	VBZ
cord-321868-xk4yuibj	391	16	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	391	17	.	.	.
cord-321868-xk4yuibj	392	1	Addition	addition	NN
cord-321868-xk4yuibj	392	2	of	of	IN
cord-321868-xk4yuibj	392	3	another	another	DT
cord-321868-xk4yuibj	392	4	codon	codon	NN
cord-321868-xk4yuibj	392	5	between	between	IN
cord-321868-xk4yuibj	392	6	the	the	DT
cord-321868-xk4yuibj	392	7	initiation	initiation	NN
cord-321868-xk4yuibj	392	8	codon	codon	NN
cord-321868-xk4yuibj	392	9	and	and	CC
cord-321868-xk4yuibj	392	10	the	the	DT
cord-321868-xk4yuibj	392	11	frameshift	frameshift	NN
cord-321868-xk4yuibj	392	12	site	site	NN
cord-321868-xk4yuibj	392	13	restores	restore	VBZ
cord-321868-xk4yuibj	392	14	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	392	15	.	.	.
cord-321868-xk4yuibj	393	1	This	this	DT
cord-321868-xk4yuibj	393	2	proximity	proximity	NN
cord-321868-xk4yuibj	393	3	effect	effect	NN
cord-321868-xk4yuibj	393	4	has	have	VBZ
cord-321868-xk4yuibj	393	5	not	not	RB
cord-321868-xk4yuibj	393	6	been	be	VBN
cord-321868-xk4yuibj	393	7	observed	observe	VBN
cord-321868-xk4yuibj	393	8	or	or	CC
cord-321868-xk4yuibj	393	9	examined	examine	VBN
cord-321868-xk4yuibj	393	10	in	in	IN
cord-321868-xk4yuibj	393	11	other	other	JJ
cord-321868-xk4yuibj	393	12	systems	system	NNS
cord-321868-xk4yuibj	393	13	and	and	CC
cord-321868-xk4yuibj	393	14	may	may	MD
cord-321868-xk4yuibj	393	15	be	be	VB
cord-321868-xk4yuibj	393	16	a	a	DT
cord-321868-xk4yuibj	393	17	general	general	JJ
cord-321868-xk4yuibj	393	18	phenomenon	phenomenon	NN
cord-321868-xk4yuibj	393	19	.	.	.
cord-321868-xk4yuibj	394	1	We	-PRON-	PRP
cord-321868-xk4yuibj	394	2	hypothesize	hypothesize	VBP
cord-321868-xk4yuibj	394	3	that	that	DT
cord-321868-xk4yuibj	394	4	translation	translation	NN
cord-321868-xk4yuibj	394	5	immediately	immediately	RB
cord-321868-xk4yuibj	394	6	after	after	IN
cord-321868-xk4yuibj	394	7	initiation	initiation	NN
cord-321868-xk4yuibj	394	8	might	may	MD
cord-321868-xk4yuibj	394	9	be	be	VB
cord-321868-xk4yuibj	394	10	fundamentally	fundamentally	RB
cord-321868-xk4yuibj	394	11	different	different	JJ
cord-321868-xk4yuibj	394	12	from	from	IN
cord-321868-xk4yuibj	394	13	that	that	DT
cord-321868-xk4yuibj	394	14	during	during	IN
cord-321868-xk4yuibj	394	15	the	the	DT
cord-321868-xk4yuibj	394	16	elongation	elongation	NN
cord-321868-xk4yuibj	394	17	phase	phase	NN
cord-321868-xk4yuibj	394	18	.	.	.
cord-321868-xk4yuibj	395	1	This	this	DT
cord-321868-xk4yuibj	395	2	difference	difference	NN
cord-321868-xk4yuibj	395	3	could	could	MD
cord-321868-xk4yuibj	395	4	perturb	perturb	VB
cord-321868-xk4yuibj	395	5	the	the	DT
cord-321868-xk4yuibj	395	6	ribosome	ribosome	NN
cord-321868-xk4yuibj	395	7	's	's	POS
cord-321868-xk4yuibj	395	8	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	395	9	ability	ability	NN
cord-321868-xk4yuibj	395	10	.	.	.
cord-321868-xk4yuibj	396	1	Experiments	experiment	NNS
cord-321868-xk4yuibj	396	2	are	be	VBP
cord-321868-xk4yuibj	396	3	under	under	IN
cord-321868-xk4yuibj	396	4	way	way	NN
cord-321868-xk4yuibj	396	5	to	to	TO
cord-321868-xk4yuibj	396	6	understand	understand	VB
cord-321868-xk4yuibj	396	7	what	what	WDT
cord-321868-xk4yuibj	396	8	elements	element	NNS
cord-321868-xk4yuibj	396	9	determine	determine	VBP
cord-321868-xk4yuibj	396	10	the	the	DT
cord-321868-xk4yuibj	396	11	ribosome	ribosome	NN
cord-321868-xk4yuibj	396	12	's	's	POS
cord-321868-xk4yuibj	396	13	ability	ability	NN
cord-321868-xk4yuibj	396	14	to	to	TO
cord-321868-xk4yuibj	396	15	frameshift	frameshift	VB
cord-321868-xk4yuibj	396	16	early	early	RB
cord-321868-xk4yuibj	396	17	in	in	IN
cord-321868-xk4yuibj	396	18	elongation	elongation	NN
cord-321868-xk4yuibj	396	19	.	.	.
cord-321868-xk4yuibj	397	1	Yeast	yeast	NN
cord-321868-xk4yuibj	397	2	Strains	Strains	NNPS
cord-321868-xk4yuibj	397	3	,	,	,
cord-321868-xk4yuibj	397	4	Media	medium	NNS
cord-321868-xk4yuibj	397	5	,	,	,
cord-321868-xk4yuibj	397	6	and	and	CC
cord-321868-xk4yuibj	397	7	General	General	NNP
cord-321868-xk4yuibj	397	8	Methods	Methods	NNPS
cord-321868-xk4yuibj	398	1	The	the	DT
cord-321868-xk4yuibj	398	2	S.	S.	NNP
cord-321868-xk4yuibj	398	3	cerevisiae	cerevisiae	NN
cord-321868-xk4yuibj	398	4	strain	strain	NN
cord-321868-xk4yuibj	398	5	used	use	VBN
cord-321868-xk4yuibj	398	6	for	for	IN
cord-321868-xk4yuibj	398	7	this	this	DT
cord-321868-xk4yuibj	398	8	work	work	NN
cord-321868-xk4yuibj	398	9	unless	unless	IN
cord-321868-xk4yuibj	398	10	otherwise	otherwise	RB
cord-321868-xk4yuibj	398	11	indicated	indicate	VBD
cord-321868-xk4yuibj	398	12	is	be	VBZ
cord-321868-xk4yuibj	398	13	337	337	CD
cord-321868-xk4yuibj	398	14	-	-	HYPH
cord-321868-xk4yuibj	398	15	1D	1d	CD
cord-321868-xk4yuibj	398	16	(	(	-LRB-
cord-321868-xk4yuibj	398	17	a	a	DT
cord-321868-xk4yuibj	398	18	hi&A38um3	hi&a38um3	JJ
cord-321868-xk4yuibj	398	19	-	-	HYPH
cord-321868-xk4yuibj	398	20	52	52	CD
cord-321868-xk4yuibj	398	21	trpl-289	trpl-289	NN
cord-321868-xk4yuibj	398	22	HO	HO	NNP
cord-321868-xk4yuibj	398	23	/	/	SYM
cord-321868-xk4yuibj	398	24	J	J	NNP
cord-321868-xk4yuibj	398	25	-	-	HYPH
cord-321868-xk4yuibj	398	26	l	l	NNP
cord-321868-xk4yuibj	398	27	)	)	-RRB-
cord-321868-xk4yuibj	398	28	.	.	.
cord-321868-xk4yuibj	399	1	Analysis	analysis	NN
cord-321868-xk4yuibj	399	2	of	of	IN
cord-321868-xk4yuibj	399	3	directionality	directionality	NN
cord-321868-xk4yuibj	399	4	plasmids	plasmid	NNS
cord-321868-xk4yuibj	399	5	was	be	VBD
cord-321868-xk4yuibj	399	6	also	also	RB
cord-321868-xk4yuibj	399	7	done	do	VBN
cord-321868-xk4yuibj	399	8	in	in	IN
cord-321868-xk4yuibj	399	9	strain	strain	NN
cord-321868-xk4yuibj	400	1	LO361	LO361	NNP
cord-321868-xk4yuibj	400	2	(	(	-LRB-
cord-321868-xk4yuibj	400	3	a	a	DT
cord-321868-xk4yuibj	400	4	his&z8	his&z8	JJ
cord-321868-xk4yuibj	400	5	lysl-1-o	lysl-1-o	:
cord-321868-xk4yuibj	400	6	met8-l	met8-l	NNP
cord-321868-xk4yuibj	400	7	-	-	HYPH
cord-321868-xk4yuibj	400	8	am	am	NNP
cord-321868-xk4yuibj	400	9	sup43	sup43	CD
cord-321868-xk4yuibj	401	1	ura3	ura3	CD
cord-321868-xk4yuibj	401	2	-	-	SYM
cord-321868-xk4yuibj	401	3	52	52	CD
cord-321868-xk4yuibj	401	4	)	)	-RRB-
cord-321868-xk4yuibj	401	5	kindly	kindly	RB
cord-321868-xk4yuibj	401	6	provided	provide	VBN
cord-321868-xk4yuibj	401	7	by	by	IN
cord-321868-xk4yuibj	401	8	Gerald	Gerald	NNP
cord-321868-xk4yuibj	401	9	Fink	Fink	NNP
cord-321868-xk4yuibj	401	10	.	.	.
cord-321868-xk4yuibj	402	1	This	this	DT
cord-321868-xk4yuibj	402	2	strain	strain	NN
cord-321868-xk4yuibj	402	3	carries	carry	VBZ
cord-321868-xk4yuibj	402	4	a	a	DT
cord-321868-xk4yuibj	402	5	temperature	temperature	NN
cord-321868-xk4yuibj	402	6	-	-	HYPH
cord-321868-xk4yuibj	402	7	sensitive	sensitive	JJ
cord-321868-xk4yuibj	402	8	amber	amber	NN
cord-321868-xk4yuibj	402	9	suppressor	suppressor	NN
cord-321868-xk4yuibj	402	10	,	,	,
cord-321868-xk4yuibj	402	11	suppressing	suppress	VBG
cord-321868-xk4yuibj	402	12	at	at	IN
cord-321868-xk4yuibj	402	13	3tX	3tx	CD
cord-321868-xk4yuibj	402	14	but	but	CC
cord-321868-xk4yuibj	402	15	not	not	RB
cord-321868-xk4yuibj	402	16	at	at	IN
cord-321868-xk4yuibj	402	17	37	37	CD
cord-321868-xk4yuibj	402	18	%	%	NN
cord-321868-xk4yuibj	402	19	.	.	.
cord-321868-xk4yuibj	403	1	Analysis	analysis	NN
cord-321868-xk4yuibj	403	2	of	of	IN
cord-321868-xk4yuibj	403	3	tyrosine	tyrosine	NN
cord-321868-xk4yuibj	403	4	codon	codon	NN
cord-321868-xk4yuibj	403	5	substitutions	substitution	NNS
cord-321868-xk4yuibj	403	6	was	be	VBD
cord-321868-xk4yuibj	403	7	done	do	VBN
cord-321868-xk4yuibj	403	8	in	in	IN
cord-321868-xk4yuibj	403	9	strains	strain	NNS
cord-321868-xk4yuibj	403	10	kindly	kindly	RB
cord-321868-xk4yuibj	403	11	provided	provide	VBN
cord-321868-xk4yuibj	403	12	by	by	IN
cord-321868-xk4yuibj	403	13	Maynard	Maynard	NNP
cord-321868-xk4yuibj	403	14	Olson	Olson	NNP
cord-321868-xk4yuibj	403	15	.	.	.
cord-321868-xk4yuibj	404	1	The	the	DT
cord-321868-xk4yuibj	404	2	strains	strain	NNS
cord-321868-xk4yuibj	404	3	are	be	VBP
cord-321868-xk4yuibj	404	4	deleted	delete	VBN
cord-321868-xk4yuibj	404	5	for	for	IN
cord-321868-xk4yuibj	404	6	one	one	CD
cord-321868-xk4yuibj	404	7	to	to	TO
cord-321868-xk4yuibj	404	8	six	six	CD
cord-321868-xk4yuibj	404	9	copies	copy	NNS
cord-321868-xk4yuibj	404	10	of	of	IN
cord-321868-xk4yuibj	404	11	the	the	DT
cord-321868-xk4yuibj	404	12	eight	eight	CD
cord-321868-xk4yuibj	404	13	tRNA	tRNA	NNP
cord-321868-xk4yuibj	404	14	&	&	CC
cord-321868-xk4yuibj	404	15	genetic	genetic	JJ
cord-321868-xk4yuibj	404	16	loci	locus	NNS
cord-321868-xk4yuibj	404	17	(	(	-LRB-
cord-321868-xk4yuibj	404	18	sup2	sup2	NN
cord-321868-xk4yuibj	404	19	-	-	HYPH
cord-321868-xk4yuibj	404	20	3	3	CD
cord-321868-xk4yuibj	404	21	,	,	,
cord-321868-xk4yuibj	404	22	71	71	CD
cord-321868-xk4yuibj	404	23	)	)	-RRB-
cord-321868-xk4yuibj	404	24	and	and	CC
cord-321868-xk4yuibj	404	25	have	have	VBP
cord-321868-xk4yuibj	404	26	the	the	DT
cord-321868-xk4yuibj	404	27	following	following	JJ
cord-321868-xk4yuibj	404	28	genotype	genotype	NN
cord-321868-xk4yuibj	404	29	:	:	:
cord-321868-xk4yuibj	404	30	MAW	MAW	NNP
cord-321868-xk4yuibj	404	31	or	or	CC
cord-321868-xk4yuibj	404	32	a	a	DT
cord-321868-xk4yuibj	404	33	a&2-l	a&2-l	NN
cord-321868-xk4yuibj	404	34	-	-	HYPH
cord-321868-xk4yuibj	404	35	o	o	NN
cord-321868-xk4yuibj	404	36	/ys2	/ys2	.
cord-321868-xk4yuibj	404	37	-	-	:
cord-321868-xk4yuibj	404	38	7-o	7-o	CD
cord-321868-xk4yuibj	404	39	trp52-o	trp52-o	NNP
cord-321868-xk4yuibj	404	40	leul-12	leul-12	NNP
cord-321868-xk4yuibj	404	41	canlloo-0	canlloo-0	NNP
cord-321868-xk4yuibj	404	42	~~3	~~3	NNP
cord-321868-xk4yuibj	404	43	-	-	HYPH
cord-321868-xk4yuibj	404	44	1	1	CD
cord-321868-xk4yuibj	404	45	met4-l	met4-l	NNP
cord-321868-xk4yuibj	404	46	-	-	HYPH
cord-321868-xk4yuibj	404	47	o	o	NNP
cord-321868-xk4yuibj	404	48	(	(	-LRB-
cord-321868-xk4yuibj	404	49	Burke	Burke	NNP
cord-321868-xk4yuibj	404	50	,	,	,
cord-321868-xk4yuibj	404	51	1988	1988	CD
cord-321868-xk4yuibj	404	52	)	)	-RRB-
cord-321868-xk4yuibj	404	53	.	.	.
cord-321868-xk4yuibj	405	1	Strain	strain	NN
cord-321868-xk4yuibj	405	2	ABl143	ABl143	NNS
cord-321868-xk4yuibj	405	3	is	be	VBZ
cord-321868-xk4yuibj	405	4	deleted	delete	VBN
cord-321868-xk4yuibj	405	5	for	for	IN
cord-321868-xk4yuibj	405	6	sup8	sup8	NN
cord-321868-xk4yuibj	405	7	;	;	:
cord-321868-xk4yuibj	405	8	 	 	_SP
cord-321868-xk4yuibj	405	9	The	the	DT
cord-321868-xk4yuibj	405	10	plasmid	plasmid	NN
cord-321868-xk4yuibj	405	11	pMB38	pmb38	NN
cord-321868-xk4yuibj	405	12	is	be	VBZ
cord-321868-xk4yuibj	405	13	shown	show	VBN
cord-321868-xk4yuibj	405	14	in	in	IN
cord-321868-xk4yuibj	405	15	Figure	figure	NN
cord-321868-xk4yuibj	405	16	1	1	CD
cord-321868-xk4yuibj	405	17	.	.	.
cord-321868-xk4yuibj	406	1	This	this	DT
cord-321868-xk4yuibj	406	2	plasmid	plasmid	NN
cord-321868-xk4yuibj	406	3	contains	contain	VBZ
cord-321868-xk4yuibj	406	4	the	the	DT
cord-321868-xk4yuibj	406	5	URA3	URA3	NNP
cord-321868-xk4yuibj	406	6	gene	gene	NN
cord-321868-xk4yuibj	406	7	and	and	CC
cord-321868-xk4yuibj	406	8	the	the	DT
cord-321868-xk4yuibj	406	9	2um	2um	JJ
cord-321868-xk4yuibj	406	10	origin	origin	NN
cord-321868-xk4yuibj	406	11	of	of	IN
cord-321868-xk4yuibj	406	12	replication	replication	NN
cord-321868-xk4yuibj	406	13	from	from	IN
cord-321868-xk4yuibj	406	14	pLGSD5	pLGSD5	NNP
cord-321868-xk4yuibj	406	15	(	(	-LRB-
cord-321868-xk4yuibj	406	16	Guarente	Guarente	NNP
cord-321868-xk4yuibj	406	17	et	et	FW
cord-321868-xk4yuibj	406	18	al	al	NNP
cord-321868-xk4yuibj	406	19	.	.	NNP
cord-321868-xk4yuibj	406	20	,	,	,
cord-321868-xk4yuibj	406	21	1982	1982	CD
cord-321868-xk4yuibj	406	22	)	)	-RRB-
cord-321868-xk4yuibj	406	23	and	and	CC
cord-321868-xk4yuibj	406	24	a	a	DT
cord-321868-xk4yuibj	406	25	Struncated	Struncated	NNP
cord-321868-xk4yuibj	406	26	/acZ	/acZ	NNP
cord-321868-xk4yuibj	406	27	gene	gene	NN
cord-321868-xk4yuibj	406	28	from	from	IN
cord-321868-xk4yuibj	406	29	pMC1790	pmc1790	NN
cord-321868-xk4yuibj	406	30	(	(	-LRB-
cord-321868-xk4yuibj	406	31	Casadaban	Casadaban	NNP
cord-321868-xk4yuibj	406	32	et	et	NNP
cord-321868-xk4yuibj	406	33	al	al	NNP
cord-321868-xk4yuibj	406	34	.	.	NNP
cord-321868-xk4yuibj	406	35	,	,	,
cord-321868-xk4yuibj	406	36	1983	1983	CD
cord-321868-xk4yuibj	406	37	)	)	-RRB-
cord-321868-xk4yuibj	406	38	;	;	:
cord-321868-xk4yuibj	406	39	the	the	DT
cord-321868-xk4yuibj	406	40	construction	construction	NN
cord-321868-xk4yuibj	406	41	of	of	IN
cord-321868-xk4yuibj	406	42	this	this	DT
cord-321868-xk4yuibj	406	43	portion	portion	NN
cord-321868-xk4yuibj	406	44	of	of	IN
cord-321868-xk4yuibj	406	45	the	the	DT
cord-321868-xk4yuibj	406	46	plasmid	plasmid	NN
cord-321868-xk4yuibj	406	47	has	have	VBZ
cord-321868-xk4yuibj	406	48	been	be	VBN
cord-321868-xk4yuibj	406	49	described	describe	VBN
cord-321868-xk4yuibj	406	50	(	(	-LRB-
cord-321868-xk4yuibj	407	1	Liao	Liao	NNP
cord-321868-xk4yuibj	407	2	et	et	NNP
cord-321868-xk4yuibj	407	3	al	al	NNP
cord-321868-xk4yuibj	407	4	.	.	NNP
cord-321868-xk4yuibj	407	5	,	,	,
cord-321868-xk4yuibj	407	6	1987	1987	CD
cord-321868-xk4yuibj	407	7	)	)	-RRB-
cord-321868-xk4yuibj	407	8	.	.	.
cord-321868-xk4yuibj	408	1	The	the	DT
cord-321868-xk4yuibj	408	2	HIS4.A	HIS4.A	NNP
cord-321868-xk4yuibj	408	3	gene	gene	NN
cord-321868-xk4yuibj	408	4	was	be	VBD
cord-321868-xk4yuibj	408	5	introduced	introduce	VBN
cord-321868-xk4yuibj	408	6	as	as	IN
cord-321868-xk4yuibj	408	7	a	a	DT
cord-321868-xk4yuibj	408	8	1.2	1.2	CD
cord-321868-xk4yuibj	408	9	kb	kb	NNP
cord-321868-xk4yuibj	408	10	Sall	Sall	NNP
cord-321868-xk4yuibj	408	11	-	-	HYPH
cord-321868-xk4yuibj	408	12	BamHI	BamHI	NNP
cord-321868-xk4yuibj	408	13	fragment	fragment	NN
cord-321868-xk4yuibj	408	14	between	between	IN
cord-321868-xk4yuibj	408	15	the	the	DT
cord-321868-xk4yuibj	408	16	Xhol	Xhol	NNP
cord-321868-xk4yuibj	408	17	and	and	CC
cord-321868-xk4yuibj	408	18	BamHl	BamHl	NNP
cord-321868-xk4yuibj	408	19	sites	site	NNS
cord-321868-xk4yuibj	408	20	of	of	IN
cord-321868-xk4yuibj	408	21	pNoUp	pNoUp	NNP
cord-321868-xk4yuibj	409	1	(	(	-LRB-
cord-321868-xk4yuibj	409	2	Liao	Liao	NNP
cord-321868-xk4yuibj	409	3	et	et	NNP
cord-321868-xk4yuibj	409	4	al	al	NNP
cord-321868-xk4yuibj	409	5	.	.	NNP
cord-321868-xk4yuibj	409	6	,	,	,
cord-321868-xk4yuibj	409	7	1987	1987	CD
cord-321868-xk4yuibj	409	8	)	)	-RRB-
cord-321868-xk4yuibj	409	9	.	.	.
cord-321868-xk4yuibj	410	1	Replacement	replacement	NN
cord-321868-xk4yuibj	410	2	of	of	IN
cord-321868-xk4yuibj	410	3	the	the	DT
cord-321868-xk4yuibj	410	4	BamHI	bamhi	NN
cord-321868-xk4yuibj	410	5	-	-	HYPH
cord-321868-xk4yuibj	410	6	Sacl	Sacl	NNP
cord-321868-xk4yuibj	410	7	laczfragment	laczfragment	NN
cord-321868-xk4yuibj	410	8	with	with	IN
cord-321868-xk4yuibj	410	9	the	the	DT
cord-321868-xk4yuibj	410	10	complementary	complementary	JJ
cord-321868-xk4yuibj	410	11	fragment	fragment	NN
cord-321868-xk4yuibj	410	12	containing	contain	VBG
cord-321868-xk4yuibj	410	13	the	the	DT
cord-321868-xk4yuibj	410	14	BamHI	BamHI	NNP
cord-321868-xk4yuibj	410	15	-	-	HYPH
cord-321868-xk4yuibj	410	16	Kpnl	Kpnl	NNP
cord-321868-xk4yuibj	410	17	linker	linker	NN
cord-321868-xk4yuibj	410	18	at	at	IN
cord-321868-xk4yuibj	410	19	the	the	DT
cord-321868-xk4yuibj	410	20	5'end	5'end	CD
cord-321868-xk4yuibj	410	21	of	of	IN
cord-321868-xk4yuibj	410	22	/a&creates	/a&creates	CD
cord-321868-xk4yuibj	410	23	pMB38	pMB38	NNS
cord-321868-xk4yuibj	410	24	.	.	.
cord-321868-xk4yuibj	411	1	The	the	DT
cord-321868-xk4yuibj	411	2	laczgene	laczgene	NN
cord-321868-xk4yuibj	411	3	is	be	VBZ
cord-321868-xk4yuibj	411	4	fused	fuse	VBN
cord-321868-xk4yuibj	411	5	via	via	IN
cord-321868-xk4yuibj	411	6	a	a	DT
cord-321868-xk4yuibj	411	7	BamHI	BamHI	NNP
cord-321868-xk4yuibj	411	8	-	-	HYPH
cord-321868-xk4yuibj	411	9	Kpnl	Kpnl	NNP
cord-321868-xk4yuibj	411	10	linker	linker	NN
cord-321868-xk4yuibj	411	11	to	to	IN
cord-321868-xk4yuibj	411	12	the	the	DT
cord-321868-xk4yuibj	411	13	HIS4A	HIS4A	NNP
cord-321868-xk4yuibj	411	14	gene	gene	NN
cord-321868-xk4yuibj	411	15	33	33	CD
cord-321868-xk4yuibj	411	16	codons	codon	NNS
cord-321868-xk4yuibj	411	17	downstream	downstream	RB
cord-321868-xk4yuibj	411	18	of	of	IN
cord-321868-xk4yuibj	411	19	the	the	DT
cord-321868-xk4yuibj	411	20	HI.%4	HI.%4	NNP
cord-321868-xk4yuibj	411	21	initiation	initiation	NN
cord-321868-xk4yuibj	411	22	codon	codon	NN
cord-321868-xk4yuibj	411	23	.	.	.
cord-321868-xk4yuibj	412	1	Missense	Missense	NNP
cord-321868-xk4yuibj	412	2	,	,	,
cord-321868-xk4yuibj	412	3	codon	codon	NN
cord-321868-xk4yuibj	412	4	substitution	substitution	NN
cord-321868-xk4yuibj	412	5	,	,	,
cord-321868-xk4yuibj	412	6	and	and	CC
cord-321868-xk4yuibj	412	7	directionality	directionality	NN
cord-321868-xk4yuibj	412	8	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	412	9	containing	contain	VBG
cord-321868-xk4yuibj	412	10	the	the	DT
cord-321868-xk4yuibj	412	11	9	9	CD
cord-321868-xk4yuibj	412	12	bp	bp	NNP
cord-321868-xk4yuibj	412	13	and	and	CC
cord-321868-xk4yuibj	412	14	14	14	CD
cord-321868-xk4yuibj	412	15	bp	bp	NNP
cord-321868-xk4yuibj	412	16	frameshift	frameshift	NN
cord-321868-xk4yuibj	412	17	sites	site	NNS
cord-321868-xk4yuibj	412	18	were	be	VBD
cord-321868-xk4yuibj	412	19	introduced	introduce	VBN
cord-321868-xk4yuibj	412	20	between	between	IN
cord-321868-xk4yuibj	412	21	the	the	DT
cord-321868-xk4yuibj	412	22	BamHl	BamHl	NNP
cord-321868-xk4yuibj	412	23	and	and	CC
cord-321868-xk4yuibj	412	24	Kpnl	Kpnl	NNP
cord-321868-xk4yuibj	412	25	sites	site	NNS
cord-321868-xk4yuibj	412	26	as	as	IN
cord-321868-xk4yuibj	412	27	described	describe	VBN
cord-321868-xk4yuibj	412	28	by	by	IN
cord-321868-xk4yuibj	412	29	Derbyshire	Derbyshire	NNP
cord-321868-xk4yuibj	412	30	et	et	NNP
cord-321868-xk4yuibj	412	31	al	al	NNP
cord-321868-xk4yuibj	412	32	.	.	.
cord-321868-xk4yuibj	413	1	(	(	-LRB-
cord-321868-xk4yuibj	413	2	1986	1986	CD
cord-321868-xk4yuibj	413	3	)	)	-RRB-
cord-321868-xk4yuibj	413	4	.	.	.
cord-321868-xk4yuibj	414	1	The	the	DT
cord-321868-xk4yuibj	414	2	sequences	sequence	NNS
cord-321868-xk4yuibj	414	3	of	of	IN
cord-321868-xk4yuibj	414	4	directionality	directionality	NN
cord-321868-xk4yuibj	414	5	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	414	6	are	be	VBP
cord-321868-xk4yuibj	414	7	shown	show	VBN
cord-321868-xk4yuibj	414	8	in	in	IN
cord-321868-xk4yuibj	414	9	Table	Table	NNP
cord-321868-xk4yuibj	414	10	7	7	CD
cord-321868-xk4yuibj	414	11	.	.	.
cord-321868-xk4yuibj	415	1	Missense	missense	NN
cord-321868-xk4yuibj	415	2	and	and	CC
cord-321868-xk4yuibj	415	3	codon	codon	NN
cord-321868-xk4yuibj	415	4	substitution	substitution	NN
cord-321868-xk4yuibj	415	5	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	415	6	have	have	VBP
cord-321868-xk4yuibj	415	7	the	the	DT
cord-321868-xk4yuibj	415	8	following	follow	VBG
cord-321868-xk4yuibj	415	9	general	general	JJ
cord-321868-xk4yuibj	415	10	sequence	sequence	NN
cord-321868-xk4yuibj	415	11	:	:	:
cord-321868-xk4yuibj	415	12	SGATCCGCTGACACTT	SGATCCGCTGACACTT	NNP
cord-321868-xk4yuibj	415	13	~	~	NFP
cord-321868-xk4yuibj	415	14	GCCA	GCCA	NNP
cord-321868-xk4yuibj	415	15	-	-	HYPH
cord-321868-xk4yuibj	415	16	TGAGGTAC-3	TGAGGTAC-3	NNP
cord-321868-xk4yuibj	415	17	'	'	''
cord-321868-xk4yuibj	415	18	.	.	.
cord-321868-xk4yuibj	416	1	This	this	DT
cord-321868-xk4yuibj	416	2	oligonucleotide	oligonucleotide	NN
cord-321868-xk4yuibj	416	3	contains	contain	VBZ
cord-321868-xk4yuibj	416	4	5'and	5'and	CD
cord-321868-xk4yuibj	416	5	3'overhangs	3'overhangs	CD
cord-321868-xk4yuibj	416	6	complementary	complementary	JJ
cord-321868-xk4yuibj	416	7	to	to	IN
cord-321868-xk4yuibj	416	8	BamHl	BamHl	NNP
cord-321868-xk4yuibj	416	9	and	and	CC
cord-321868-xk4yuibj	416	10	Kpnl	Kpnl	NNP
cord-321868-xk4yuibj	416	11	half	half	JJ
cord-321868-xk4yuibj	416	12	-	-	HYPH
cord-321868-xk4yuibj	416	13	sites	site	NNS
cord-321868-xk4yuibj	416	14	,	,	,
cord-321868-xk4yuibj	416	15	respectively	respectively	RB
cord-321868-xk4yuibj	416	16	.	.	.
cord-321868-xk4yuibj	417	1	This	this	DT
cord-321868-xk4yuibj	417	2	allowed	allow	VBD
cord-321868-xk4yuibj	417	3	cloning	clone	VBG
cord-321868-xk4yuibj	417	4	into	into	IN
cord-321868-xk4yuibj	417	5	pMB38	pMB38	NNS
cord-321868-xk4yuibj	417	6	as	as	IN
cord-321868-xk4yuibj	417	7	described	describe	VBN
cord-321868-xk4yuibj	417	8	above	above	RB
cord-321868-xk4yuibj	417	9	.	.	.
cord-321868-xk4yuibj	418	1	The	the	DT
cord-321868-xk4yuibj	418	2	underlined	underlined	JJ
cord-321868-xk4yuibj	418	3	region	region	NN
cord-321868-xk4yuibj	418	4	was	be	VBD
cord-321868-xk4yuibj	418	5	subjected	subject	VBN
cord-321868-xk4yuibj	418	6	to	to	IN
cord-321868-xk4yuibj	418	7	missense	missense	NN
cord-321868-xk4yuibj	418	8	mutagenesis	mutagenesis	NN
cord-321868-xk4yuibj	418	9	as	as	IN
cord-321868-xk4yuibj	418	10	described	describe	VBN
cord-321868-xk4yuibj	418	11	in	in	IN
cord-321868-xk4yuibj	418	12	the	the	DT
cord-321868-xk4yuibj	418	13	text	text	NN
cord-321868-xk4yuibj	418	14	or	or	CC
cord-321868-xk4yuibj	418	15	changed	change	VBD
cord-321868-xk4yuibj	418	16	to	to	IN
cord-321868-xk4yuibj	418	17	specific	specific	JJ
cord-321868-xk4yuibj	418	18	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	418	19	as	as	IN
cord-321868-xk4yuibj	418	20	described	describe	VBN
cord-321868-xk4yuibj	418	21	in	in	IN
cord-321868-xk4yuibj	418	22	the	the	DT
cord-321868-xk4yuibj	418	23	section	section	NN
cord-321868-xk4yuibj	418	24	on	on	IN
cord-321868-xk4yuibj	418	25	codon	codon	NN
cord-321868-xk4yuibj	418	26	substitutions	substitution	NNS
cord-321868-xk4yuibj	418	27	(	(	-LRB-
cord-321868-xk4yuibj	418	28	see	see	VB
cord-321868-xk4yuibj	418	29	Table	Table	NNP
cord-321868-xk4yuibj	418	30	7	7	CD
cord-321868-xk4yuibj	418	31	)	)	-RRB-
cord-321868-xk4yuibj	418	32	.	.	.
cord-321868-xk4yuibj	419	1	An	an	DT
cord-321868-xk4yuibj	419	2	oligonucleotide	oligonucleotide	JJ
cord-321868-xk4yuibj	419	3	identical	identical	JJ
cord-321868-xk4yuibj	419	4	to	to	IN
cord-321868-xk4yuibj	419	5	this	this	DT
cord-321868-xk4yuibj	419	6	except	except	IN
cord-321868-xk4yuibj	419	7	for	for	IN
cord-321868-xk4yuibj	419	8	an	an	DT
cord-321868-xk4yuibj	419	9	addition	addition	NN
cord-321868-xk4yuibj	419	10	of	of	IN
cord-321868-xk4yuibj	419	11	2	2	CD
cord-321868-xk4yuibj	419	12	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	419	13	following	follow	VBG
cord-321868-xk4yuibj	419	14	the	the	DT
cord-321868-xk4yuibj	419	15	underlined	underline	VBN
cord-321868-xk4yuibj	419	16	sequence	sequence	NN
cord-321868-xk4yuibj	419	17	fuses	fuse	VBZ
cord-321868-xk4yuibj	419	18	the	the	DT
cord-321868-xk4yuibj	419	19	upstream	upstream	JJ
cord-321868-xk4yuibj	419	20	and	and	CC
cord-321868-xk4yuibj	419	21	downstream	downstream	JJ
cord-321868-xk4yuibj	419	22	reading	reading	NN
cord-321868-xk4yuibj	419	23	frames	frame	NNS
cord-321868-xk4yuibj	419	24	in	in	IN
cord-321868-xk4yuibj	419	25	frame	frame	NN
cord-321868-xk4yuibj	419	26	.	.	.
cord-321868-xk4yuibj	420	1	This	this	DT
cord-321868-xk4yuibj	420	2	oligonucleotide	oligonucleotide	NN
cord-321868-xk4yuibj	420	3	(	(	-LRB-
cord-321868-xk4yuibj	420	4	called	call	VBN
cord-321868-xk4yuibj	420	5	Smer	Smer	NNP
cord-321868-xk4yuibj	420	6	-	-	HYPH
cord-321868-xk4yuibj	420	7	fusion	fusion	NN
cord-321868-xk4yuibj	420	8	;	;	:
cord-321868-xk4yuibj	420	9	Table	Table	NNP
cord-321868-xk4yuibj	420	10	7	7	CD
cord-321868-xk4yuibj	420	11	)	)	-RRB-
cord-321868-xk4yuibj	420	12	allows	allow	VBZ
cord-321868-xk4yuibj	420	13	for	for	IN
cord-321868-xk4yuibj	420	14	quantitation	quantitation	NN
cord-321868-xk4yuibj	420	15	of	of	IN
cord-321868-xk4yuibj	420	16	the	the	DT
cord-321868-xk4yuibj	420	17	level	level	NN
cord-321868-xk4yuibj	420	18	of	of	IN
cord-321868-xk4yuibj	420	19	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	420	20	.	.	.
cord-321868-xk4yuibj	421	1	Top	top	JJ
cord-321868-xk4yuibj	421	2	and	and	CC
cord-321868-xk4yuibj	421	3	bottom	bottom	JJ
cord-321868-xk4yuibj	421	4	strands	strand	NNS
cord-321868-xk4yuibj	421	5	of	of	IN
cord-321868-xk4yuibj	421	6	flanking	flank	VBG
cord-321868-xk4yuibj	421	7	terminator	terminator	NN
cord-321868-xk4yuibj	421	8	and	and	CC
cord-321868-xk4yuibj	421	9	codon	codon	NN
cord-321868-xk4yuibj	421	10	deletion	deletion	NN
cord-321868-xk4yuibj	421	11	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	421	12	,	,	,
cord-321868-xk4yuibj	421	13	depicted	depict	VBN
cord-321868-xk4yuibj	421	14	in	in	IN
cord-321868-xk4yuibj	421	15	Table	Table	NNP
cord-321868-xk4yuibj	421	16	7	7	CD
cord-321868-xk4yuibj	421	17	,	,	,
cord-321868-xk4yuibj	421	18	were	be	VBD
cord-321868-xk4yuibj	421	19	annealed	anneal	VBN
cord-321868-xk4yuibj	421	20	and	and	CC
cord-321868-xk4yuibj	421	21	cloned	clone	VBN
cord-321868-xk4yuibj	421	22	into	into	IN
cord-321868-xk4yuibj	421	23	the	the	DT
cord-321868-xk4yuibj	421	24	BamHl	BamHl	NNP
cord-321868-xk4yuibj	421	25	site	site	NN
cord-321868-xk4yuibj	421	26	of	of	IN
cord-321868-xk4yuibj	421	27	pMB25	pMB25	NNP
cord-321868-xk4yuibj	421	28	as	as	IN
cord-321868-xk4yuibj	421	29	described	describe	VBN
cord-321868-xk4yuibj	421	30	in	in	IN
cord-321868-xk4yuibj	421	31	Clare	Clare	NNP
cord-321868-xk4yuibj	421	32	et	et	NNP
cord-321868-xk4yuibj	421	33	al	al	NNP
cord-321868-xk4yuibj	421	34	.	.	.
cord-321868-xk4yuibj	422	1	(	(	-LRB-
cord-321868-xk4yuibj	422	2	1988	1988	CD
cord-321868-xk4yuibj	422	3	)	)	-RRB-
cord-321868-xk4yuibj	422	4	.	.	.
cord-321868-xk4yuibj	423	1	pMB25	pMB25	NNP
cord-321868-xk4yuibj	423	2	is	be	VBZ
cord-321868-xk4yuibj	423	3	identical	identical	JJ
cord-321868-xk4yuibj	423	4	to	to	IN
cord-321868-xk4yuibj	423	5	pMB38	pMB38	NNS
cord-321868-xk4yuibj	423	6	except	except	IN
cord-321868-xk4yuibj	423	7	that	that	IN
cord-321868-xk4yuibj	423	8	it	-PRON-	PRP
cord-321868-xk4yuibj	423	9	lacks	lack	VBZ
cord-321868-xk4yuibj	423	10	the	the	DT
cord-321868-xk4yuibj	423	11	Kpnl	Kpnl	NNP
cord-321868-xk4yuibj	423	12	site	site	NN
cord-321868-xk4yuibj	423	13	at	at	IN
cord-321868-xk4yuibj	423	14	the	the	DT
cord-321868-xk4yuibj	423	15	junction	junction	NN
cord-321868-xk4yuibj	423	16	of	of	IN
cord-321868-xk4yuibj	423	17	H	H	NNP
cord-321868-xk4yuibj	423	18	/	/	SYM
cord-321868-xk4yuibj	423	19	WA	WA	NNP
cord-321868-xk4yuibj	423	20	and	and	CC
cord-321868-xk4yuibj	423	21	lacZ.	lacZ.	NNP
cord-321868-xk4yuibj	423	22	Construction	Construction	NNP
cord-321868-xk4yuibj	423	23	of	of	IN
cord-321868-xk4yuibj	423	24	"	"	``
cord-321868-xk4yuibj	423	25	proximity	proximity	NN
cord-321868-xk4yuibj	423	26	"	"	''
cord-321868-xk4yuibj	423	27	mutations	mutation	NNS
cord-321868-xk4yuibj	423	28	in	in	IN
cord-321868-xk4yuibj	423	29	the	the	DT
cord-321868-xk4yuibj	423	30	HIS4A	HIS4A	NNP
cord-321868-xk4yuibj	423	31	gene	gene	NN
cord-321868-xk4yuibj	423	32	was	be	VBD
cord-321868-xk4yuibj	423	33	done	do	VBN
cord-321868-xk4yuibj	423	34	by	by	IN
cord-321868-xk4yuibj	423	35	utilizing	utilize	VBG
cord-321868-xk4yuibj	423	36	the	the	DT
cord-321868-xk4yuibj	423	37	polymerase	polymerase	NN
cord-321868-xk4yuibj	423	38	chain	chain	NN
cord-321868-xk4yuibj	423	39	reaction	reaction	NN
cord-321868-xk4yuibj	423	40	(	(	-LRB-
cord-321868-xk4yuibj	423	41	PCR	PCR	NNP
cord-321868-xk4yuibj	423	42	)	)	-RRB-
cord-321868-xk4yuibj	423	43	.	.	.
cord-321868-xk4yuibj	424	1	An	an	DT
cord-321868-xk4yuibj	424	2	oligonucleotide	oligonucleotide	NN
cord-321868-xk4yuibj	424	3	,	,	,
cord-321868-xk4yuibj	424	4	Sal	Sal	NNP
cord-321868-xk4yuibj	424	5	-	-	HYPH
cord-321868-xk4yuibj	424	6	upstream	upstream	NNP
cord-321868-xk4yuibj	424	7	(	(	-LRB-
cord-321868-xk4yuibj	424	8	see	see	VB
cord-321868-xk4yuibj	424	9	Table	Table	NNP
cord-321868-xk4yuibj	424	10	7	7	CD
cord-321868-xk4yuibj	424	11	)	)	-RRB-
cord-321868-xk4yuibj	424	12	of	of	IN
cord-321868-xk4yuibj	424	13	which	which	WDT
cord-321868-xk4yuibj	424	14	the	the	DT
cord-321868-xk4yuibj	424	15	3	3	CD
cord-321868-xk4yuibj	424	16	'	'	SYM
cord-321868-xk4yuibj	424	17	20	20	CD
cord-321868-xk4yuibj	424	18	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	424	19	are	be	VBP
cord-321868-xk4yuibj	424	20	complementary	complementary	JJ
cord-321868-xk4yuibj	424	21	to	to	IN
cord-321868-xk4yuibj	424	22	the	the	DT
cord-321868-xk4yuibj	424	23	noncoding	noncoding	JJ
cord-321868-xk4yuibj	424	24	strand	strand	NN
cord-321868-xk4yuibj	424	25	of	of	IN
cord-321868-xk4yuibj	424	26	the	the	DT
cord-321868-xk4yuibj	424	27	HIS4.A	HIS4.A	NNP
cord-321868-xk4yuibj	424	28	gene	gene	NN
cord-321868-xk4yuibj	424	29	,	,	,
cord-321868-xk4yuibj	424	30	primes	prime	VBZ
cord-321868-xk4yuibj	424	31	synthesis	synthesis	NN
cord-321868-xk4yuibj	424	32	of	of	IN
cord-321868-xk4yuibj	424	33	the	the	DT
cord-321868-xk4yuibj	424	34	coding	code	VBG
cord-321868-xk4yuibj	424	35	strand	strand	NN
cord-321868-xk4yuibj	424	36	beginning	begin	VBG
cord-321868-xk4yuibj	424	37	708	708	CD
cord-321868-xk4yuibj	424	38	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	424	39	upstream	upstream	RB
cord-321868-xk4yuibj	424	40	of	of	IN
cord-321868-xk4yuibj	424	41	the	the	DT
cord-321868-xk4yuibj	424	42	protein	protein	NN
cord-321868-xk4yuibj	424	43	coding	code	VBG
cord-321868-xk4yuibj	424	44	region	region	NN
cord-321868-xk4yuibj	424	45	(	(	-LRB-
cord-321868-xk4yuibj	424	46	Donahue	Donahue	NNP
cord-321868-xk4yuibj	424	47	et	et	NNP
cord-321868-xk4yuibj	424	48	al	al	NNP
cord-321868-xk4yuibj	424	49	.	.	NNP
cord-321868-xk4yuibj	424	50	,	,	,
cord-321868-xk4yuibj	424	51	1982	1982	CD
cord-321868-xk4yuibj	424	52	)	)	-RRB-
cord-321868-xk4yuibj	424	53	.	.	.
cord-321868-xk4yuibj	425	1	Downstream	downstream	RB
cord-321868-xk4yuibj	425	2	,	,	,
cord-321868-xk4yuibj	425	3	six	six	CD
cord-321868-xk4yuibj	425	4	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	425	5	,	,	,
cord-321868-xk4yuibj	425	6	of	of	IN
cord-321868-xk4yuibj	425	7	which	which	WDT
cord-321868-xk4yuibj	425	8	the	the	DT
cord-321868-xk4yuibj	425	9	3'20	3'20	CD
cord-321868-xk4yuibj	425	10	nucleotides	nucleotide	NNS
cord-321868-xk4yuibj	425	11	are	be	VBP
cord-321868-xk4yuibj	425	12	complementary	complementary	JJ
cord-321868-xk4yuibj	425	13	to	to	IN
cord-321868-xk4yuibj	425	14	the	the	DT
cord-321868-xk4yuibj	425	15	coding	code	VBG
cord-321868-xk4yuibj	425	16	strand	strand	NN
cord-321868-xk4yuibj	425	17	,	,	,
cord-321868-xk4yuibj	425	18	prime	prime	JJ
cord-321868-xk4yuibj	425	19	synthesis	synthesis	NN
cord-321868-xk4yuibj	425	20	of	of	IN
cord-321868-xk4yuibj	425	21	the	the	DT
cord-321868-xk4yuibj	425	22	noncoding	noncoding	JJ
cord-321868-xk4yuibj	425	23	strand	strand	NN
cord-321868-xk4yuibj	425	24	at	at	IN
cord-321868-xk4yuibj	425	25	codon	codon	NN
cord-321868-xk4yuibj	425	26	intervals	interval	NNS
cord-321868-xk4yuibj	425	27	immediately	immediately	RB
cord-321868-xk4yuibj	425	28	after	after	IN
cord-321868-xk4yuibj	425	29	the	the	DT
cord-321868-xk4yuibj	425	30	initiation	initiation	NN
cord-321868-xk4yuibj	425	31	codon	codon	NN
cord-321868-xk4yuibj	425	32	.	.	.
cord-321868-xk4yuibj	426	1	The	the	DT
cord-321868-xk4yuibj	426	2	sequences	sequence	NNS
cord-321868-xk4yuibj	426	3	of	of	IN
cord-321868-xk4yuibj	426	4	these	these	DT
cord-321868-xk4yuibj	426	5	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	426	6	(	(	-LRB-
cord-321868-xk4yuibj	426	7	called	call	VBN
cord-321868-xk4yuibj	426	8	2p-7p	2p-7p	CD
cord-321868-xk4yuibj	426	9	)	)	-RRB-
cord-321868-xk4yuibj	426	10	are	be	VBP
cord-321868-xk4yuibj	426	11	listed	list	VBN
cord-321868-xk4yuibj	426	12	in	in	IN
cord-321868-xk4yuibj	426	13	Table	Table	NNP
cord-321868-xk4yuibj	426	14	7	7	CD
cord-321868-xk4yuibj	426	15	.	.	.
cord-321868-xk4yuibj	427	1	PCR	PCR	NNP
cord-321868-xk4yuibj	427	2	reactions	reaction	NNS
cord-321868-xk4yuibj	427	3	were	be	VBD
cord-321868-xk4yuibj	427	4	done	do	VBN
cord-321868-xk4yuibj	427	5	as	as	IN
cord-321868-xk4yuibj	427	6	described	describe	VBN
cord-321868-xk4yuibj	427	7	by	by	IN
cord-321868-xk4yuibj	427	8	the	the	DT
cord-321868-xk4yuibj	427	9	manufacturer	manufacturer	NN
cord-321868-xk4yuibj	427	10	(	(	-LRB-
cord-321868-xk4yuibj	427	11	Cetus	Cetus	NNP
cord-321868-xk4yuibj	427	12	Corporation	Corporation	NNP
cord-321868-xk4yuibj	427	13	)	)	-RRB-
cord-321868-xk4yuibj	427	14	on	on	IN
cord-321868-xk4yuibj	427	15	plasmid	plasmid	NNP
cord-321868-xk4yuibj	427	16	pSal1	pSal1	NNP
cord-321868-xk4yuibj	427	17	,	,	,
cord-321868-xk4yuibj	427	18	which	which	WDT
cord-321868-xk4yuibj	427	19	contains	contain	VBZ
cord-321868-xk4yuibj	427	20	the	the	DT
cord-321868-xk4yuibj	427	21	complete	complete	JJ
cord-321868-xk4yuibj	427	22	HIS4	HIS4	NNP
cord-321868-xk4yuibj	427	23	gene	gene	NN
cord-321868-xk4yuibj	427	24	.	.	.
cord-321868-xk4yuibj	428	1	The	the	DT
cord-321868-xk4yuibj	428	2	upstream	upstream	JJ
cord-321868-xk4yuibj	428	3	oligonucleotide	oligonucleotide	NN
cord-321868-xk4yuibj	428	4	incorporates	incorporate	VBZ
cord-321868-xk4yuibj	428	5	a	a	DT
cord-321868-xk4yuibj	428	6	Sall	Sall	NNP
cord-321868-xk4yuibj	428	7	restriction	restriction	NN
cord-321868-xk4yuibj	428	8	site	site	NN
cord-321868-xk4yuibj	428	9	with	with	IN
cord-321868-xk4yuibj	428	10	the	the	DT
cord-321868-xk4yuibj	428	11	downstream	downstream	JJ
cord-321868-xk4yuibj	428	12	oligonucleotides	oligonucleotide	NNS
cord-321868-xk4yuibj	428	13	incorporating	incorporate	VBG
cord-321868-xk4yuibj	428	14	a	a	DT
cord-321868-xk4yuibj	428	15	BamHl	BamHl	NNP
cord-321868-xk4yuibj	428	16	site	site	NN
cord-321868-xk4yuibj	428	17	.	.	.
cord-321868-xk4yuibj	429	1	The	the	DT
cord-321868-xk4yuibj	429	2	PCR	PCR	NNP
cord-321868-xk4yuibj	429	3	-	-	HYPH
cord-321868-xk4yuibj	429	4	generated	generate	VBN
cord-321868-xk4yuibj	429	5	frag	frag	NN
cord-321868-xk4yuibj	429	6	ments	ment	NNS
cord-321868-xk4yuibj	429	7	were	be	VBD
cord-321868-xk4yuibj	429	8	digested	digest	VBN
cord-321868-xk4yuibj	429	9	with	with	IN
cord-321868-xk4yuibj	429	10	Sall	Sall	NNP
cord-321868-xk4yuibj	429	11	and	and	CC
cord-321868-xk4yuibj	429	12	BamHl	BamHl	NNP
cord-321868-xk4yuibj	429	13	and	and	CC
cord-321868-xk4yuibj	429	14	cloned	clone	VBN
cord-321868-xk4yuibj	429	15	into	into	IN
cord-321868-xk4yuibj	429	16	theXhol	theXhol	NNP
cord-321868-xk4yuibj	429	17	and	and	CC
cord-321868-xk4yuibj	429	18	BamHl	BamHl	NNP
cord-321868-xk4yuibj	429	19	sites	site	NNS
cord-321868-xk4yuibj	429	20	of	of	IN
cord-321868-xk4yuibj	429	21	pNoUp	pNoUp	NNP
cord-321868-xk4yuibj	429	22	.	.	.
cord-321868-xk4yuibj	430	1	Subsequently	subsequently	RB
cord-321868-xk4yuibj	430	2	,	,	,
cord-321868-xk4yuibj	430	3	the	the	DT
cord-321868-xk4yuibj	430	4	BamHI	bamhi	NN
cord-321868-xk4yuibj	430	5	-	-	HYPH
cord-321868-xk4yuibj	430	6	Sacl	Sacl	NNP
cord-321868-xk4yuibj	430	7	laczfragment	laczfragment	NN
cord-321868-xk4yuibj	430	8	of	of	IN
cord-321868-xk4yuibj	430	9	pNoUp	pNoUp	NNP
cord-321868-xk4yuibj	430	10	was	be	VBD
cord-321868-xk4yuibj	430	11	replaced	replace	VBN
cord-321868-xk4yuibj	430	12	by	by	IN
cord-321868-xk4yuibj	430	13	either	either	CC
cord-321868-xk4yuibj	430	14	the	the	DT
cord-321868-xk4yuibj	430	15	BamHI	BamHI	NNP
cord-321868-xk4yuibj	430	16	-	-	HYPH
cord-321868-xk4yuibj	430	17	Sacl	Sacl	NNP
cord-321868-xk4yuibj	430	18	/acZ	/acZ	NNP
cord-321868-xk4yuibj	430	19	fragment	fragment	NN
cord-321868-xk4yuibj	430	20	of	of	IN
cord-321868-xk4yuibj	430	21	pMBS&SmerVvT	pMBS&SmerVvT	NNS
cord-321868-xk4yuibj	430	22	or	or	CC
cord-321868-xk4yuibj	430	23	the	the	DT
cord-321868-xk4yuibj	430	24	BamHI	BamHI	NNP
cord-321868-xk4yuibj	430	25	-	-	HYPH
cord-321868-xk4yuibj	430	26	Sacl	Sacl	NNP
cord-321868-xk4yuibj	430	27	/acZ	/acZ	NNP
cord-321868-xk4yuibj	430	28	fragment	fragment	NN
cord-321868-xk4yuibj	430	29	from	from	IN
cord-321868-xk4yuibj	430	30	pTy1812Al225-CO	pTy1812Al225-CO	NNP
cord-321868-xk4yuibj	431	1	(	(	-LRB-
cord-321868-xk4yuibj	431	2	Clare	Clare	NNP
cord-321868-xk4yuibj	431	3	et	et	NNP
cord-321868-xk4yuibj	431	4	al	al	NNP
cord-321868-xk4yuibj	431	5	.	.	NNP
cord-321868-xk4yuibj	431	6	,	,	,
cord-321868-xk4yuibj	431	7	1988	1988	CD
cord-321868-xk4yuibj	431	8	)	)	-RRB-
cord-321868-xk4yuibj	431	9	to	to	TO
cord-321868-xk4yuibj	431	10	incorporate	incorporate	VB
cord-321868-xk4yuibj	431	11	the	the	DT
cord-321868-xk4yuibj	431	12	9	9	CD
cord-321868-xk4yuibj	431	13	bp	bp	NNP
cord-321868-xk4yuibj	431	14	and	and	CC
cord-321868-xk4yuibj	431	15	14	14	CD
cord-321868-xk4yuibj	431	16	bp	bp	NNP
cord-321868-xk4yuibj	431	17	frameshift	frameshift	NN
cord-321868-xk4yuibj	431	18	sites	site	NNS
cord-321868-xk4yuibj	431	19	,	,	,
cord-321868-xk4yuibj	431	20	respectively	respectively	RB
cord-321868-xk4yuibj	431	21	.	.	.
cord-321868-xk4yuibj	432	1	The	the	DT
cord-321868-xk4yuibj	432	2	plasmid	plasmid	NN
cord-321868-xk4yuibj	432	3	used	use	VBD
cord-321868-xk4yuibj	432	4	to	to	TO
cord-321868-xk4yuibj	432	5	overexpress	overexpress	VB
cord-321868-xk4yuibj	432	6	tRNA	tRNA	NNP
cord-321868-xk4yuibj	432	7	&	&	CC
cord-321868-xk4yuibj	432	8	was	be	VBD
cord-321868-xk4yuibj	432	9	pMB3E9merWT	pmb3e9merwt	XX
cord-321868-xk4yuibj	433	1	This	this	DT
cord-321868-xk4yuibj	433	2	plasmid	plasmid	NN
cord-321868-xk4yuibj	433	3	contains	contain	VBZ
cord-321868-xk4yuibj	433	4	the	the	DT
cord-321868-xk4yuibj	433	5	missense	missense	NN
cord-321868-xk4yuibj	433	6	oligonucleotide	oligonucleotide	NN
cord-321868-xk4yuibj	433	7	depicted	depict	VBN
cord-321868-xk4yuibj	433	8	above	above	RB
cord-321868-xk4yuibj	433	9	with	with	IN
cord-321868-xk4yuibj	433	10	the	the	DT
cord-321868-xk4yuibj	433	11	wild	wild	JJ
cord-321868-xk4yuibj	433	12	-	-	HYPH
cord-321868-xk4yuibj	433	13	type	type	NN
cord-321868-xk4yuibj	433	14	9	9	CD
cord-321868-xk4yuibj	433	15	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	433	16	frameshift	frameshift	NN
cord-321868-xk4yuibj	433	17	site	site	NN
cord-321868-xk4yuibj	433	18	.	.	.
cord-321868-xk4yuibj	434	1	The	the	DT
cord-321868-xk4yuibj	434	2	unique	unique	JJ
cord-321868-xk4yuibj	434	3	TtHllll	TtHllll	NNP
cord-321868-xk4yuibj	434	4	site	site	NN
cord-321868-xk4yuibj	434	5	was	be	VBD
cord-321868-xk4yuibj	434	6	blunted	blunt	VBN
cord-321868-xk4yuibj	434	7	with	with	IN
cord-321868-xk4yuibj	434	8	DNA	dna	NN
cord-321868-xk4yuibj	434	9	polymerase	polymerase	NN
cord-321868-xk4yuibj	434	10	I	-PRON-	PRP
cord-321868-xk4yuibj	434	11	large	large	JJ
cord-321868-xk4yuibj	434	12	fragment	fragment	NN
cord-321868-xk4yuibj	434	13	and	and	CC
cord-321868-xk4yuibj	434	14	joined	join	VBD
cord-321868-xk4yuibj	434	15	to	to	IN
cord-321868-xk4yuibj	434	16	Sall	Sall	NNP
cord-321868-xk4yuibj	434	17	8-mer	8-mer	CD
cord-321868-xk4yuibj	434	18	linkers	linker	NNS
cord-321868-xk4yuibj	434	19	(	(	-LRB-
cord-321868-xk4yuibj	434	20	New	New	NNP
cord-321868-xk4yuibj	434	21	England	England	NNP
cord-321868-xk4yuibj	434	22	Biolabs	Biolabs	NNP
cord-321868-xk4yuibj	434	23	)	)	-RRB-
cord-321868-xk4yuibj	434	24	.	.	.
cord-321868-xk4yuibj	435	1	The	the	DT
cord-321868-xk4yuibj	435	2	plasmid	plasmid	NN
cord-321868-xk4yuibj	435	3	HI3	HI3	NNS
cord-321868-xk4yuibj	435	4	(	(	-LRB-
cord-321868-xk4yuibj	435	5	Gafner	Gafner	NNP
cord-321868-xk4yuibj	435	6	et	et	NNP
cord-321868-xk4yuibj	435	7	al	al	NNP
cord-321868-xk4yuibj	435	8	.	.	NNP
cord-321868-xk4yuibj	435	9	,	,	,
cord-321868-xk4yuibj	435	10	1983	1983	CD
cord-321868-xk4yuibj	435	11	)	)	-RRB-
cord-321868-xk4yuibj	435	12	the	the	DT
cord-321868-xk4yuibj	435	13	kind	kind	JJ
cord-321868-xk4yuibj	435	14	gift	gift	NN
cord-321868-xk4yuibj	435	15	of	of	IN
cord-321868-xk4yuibj	435	16	Peter	Peter	NNP
cord-321868-xk4yuibj	435	17	Philippsen	Philippsen	NNP
cord-321868-xk4yuibj	435	18	,	,	,
cord-321868-xk4yuibj	435	19	contains	contain	VBZ
cord-321868-xk4yuibj	435	20	a	a	DT
cord-321868-xk4yuibj	435	21	2.15	2.15	CD
cord-321868-xk4yuibj	435	22	kb	kb	NNP
cord-321868-xk4yuibj	435	23	Xhol	Xhol	NNP
cord-321868-xk4yuibj	435	24	fragment	fragment	NN
cord-321868-xk4yuibj	435	25	carrying	carry	VBG
cord-321868-xk4yuibj	435	26	the	the	DT
cord-321868-xk4yuibj	435	27	gene	gene	NN
cord-321868-xk4yuibj	435	28	for	for	IN
cord-321868-xk4yuibj	435	29	tRNA	tRNA	NNP
cord-321868-xk4yuibj	435	30	!	!	.
cord-321868-xk4yuibj	435	31	&	&	CC
cord-321868-xk4yuibj	435	32	.	.	.
cord-321868-xk4yuibj	436	1	This	this	DT
cord-321868-xk4yuibj	436	2	Xhol	Xhol	NNP
cord-321868-xk4yuibj	436	3	fragment	fragment	NN
cord-321868-xk4yuibj	436	4	was	be	VBD
cord-321868-xk4yuibj	436	5	cloned	clone	VBN
cord-321868-xk4yuibj	436	6	into	into	IN
cord-321868-xk4yuibj	436	7	the	the	DT
cord-321868-xk4yuibj	436	8	Sall	Sall	NNP
cord-321868-xk4yuibj	436	9	site	site	NN
cord-321868-xk4yuibj	436	10	of	of	IN
cord-321868-xk4yuibj	436	11	pMB38	pMB38	NNS
cord-321868-xk4yuibj	436	12	-	-	HYPH
cord-321868-xk4yuibj	436	13	9merWT	9merwt	CD
cord-321868-xk4yuibj	436	14	to	to	TO
cord-321868-xk4yuibj	436	15	create	create	VB
cord-321868-xk4yuibj	436	16	the	the	DT
cord-321868-xk4yuibj	436	17	plasmid	plasmid	NN
cord-321868-xk4yuibj	437	1	pMB36-SmerWT	pMB36-SmerWT	NNP
cord-321868-xk4yuibj	437	2	-	-	HYPH
cord-321868-xk4yuibj	437	3	tRNA$$	trna$$	CD
cord-321868-xk4yuibj	437	4	Le	Le	NNP
cord-321868-xk4yuibj	438	1	"	"	''
cord-321868-xk4yuibj	439	1	The	the	DT
cord-321868-xk4yuibj	439	2	tRNA	trna	NN
cord-321868-xk4yuibj	439	3	genes	gene	NNS
cord-321868-xk4yuibj	439	4	encoding	encode	VBG
cord-321868-xk4yuibj	439	5	tRNA	tRNA	NNP
cord-321868-xk4yuibj	439	6	&	&	CC
cord-321868-xk4yuibj	439	7	tRNA	tRNA	NNP
cord-321868-xk4yuibj	439	8	,	,	,
cord-321868-xk4yuibj	439	9	,	,	,
cord-321868-xk4yuibj	439	10	,	,	,
cord-321868-xk4yuibj	439	11	,	,	,
cord-321868-xk4yuibj	439	12	and	and	CC
cord-321868-xk4yuibj	439	13	tRNA	tRNA	NNP
cord-321868-xk4yuibj	439	14	,	,	,
cord-321868-xk4yuibj	439	15	u	u	NNP
cord-321868-xk4yuibj	439	16	,	,	,
cord-321868-xk4yuibj	439	17	"	"	''
cord-321868-xk4yuibj	439	18	"	"	``
cord-321868-xk4yuibj	439	19	were	be	VBD
cord-321868-xk4yuibj	439	20	overexpressed	overexpresse	VBN
cord-321868-xk4yuibj	439	21	on	on	IN
cord-321868-xk4yuibj	439	22	the	the	DT
cord-321868-xk4yuibj	439	23	same	same	JJ
cord-321868-xk4yuibj	439	24	pMB38	pMB38	NNS
cord-321868-xk4yuibj	439	25	-	-	HYPH
cord-321868-xk4yuibj	439	26	9merWf	9merwf	CD
cord-321868-xk4yuibj	439	27	plasmid	plasmid	NN
cord-321868-xk4yuibj	439	28	.	.	.
cord-321868-xk4yuibj	440	1	A	a	DT
cord-321868-xk4yuibj	440	2	gene	gene	NN
cord-321868-xk4yuibj	440	3	for	for	IN
cord-321868-xk4yuibj	440	4	tRNA	tRNA	NNP
cord-321868-xk4yuibj	440	5	&	&	CC
cord-321868-xk4yuibj	440	6	is	be	VBZ
cord-321868-xk4yuibj	440	7	found	find	VBN
cord-321868-xk4yuibj	440	8	immediately	immediately	RB
cord-321868-xk4yuibj	440	9	upstream	upstream	RB
cord-321868-xk4yuibj	440	10	of	of	IN
cord-321868-xk4yuibj	440	11	the	the	DT
cord-321868-xk4yuibj	440	12	LEUP	LEUP	NNP
cord-321868-xk4yuibj	440	13	gene	gene	NN
cord-321868-xk4yuibj	440	14	.	.	.
cord-321868-xk4yuibj	441	1	PCR	PCR	NNP
cord-321868-xk4yuibj	441	2	was	be	VBD
cord-321868-xk4yuibj	441	3	performed	perform	VBN
cord-321868-xk4yuibj	441	4	on	on	IN
cord-321868-xk4yuibj	441	5	a	a	DT
cord-321868-xk4yuibj	441	6	plasmid	plasmid	NN
cord-321868-xk4yuibj	441	7	bearing	bear	VBG
cord-321868-xk4yuibj	441	8	the	the	DT
cord-321868-xk4yuibj	441	9	2.2	2.2	CD
cord-321868-xk4yuibj	441	10	kb	kb	NNP
cord-321868-xk4yuibj	441	11	Xhol	Xhol	NNP
cord-321868-xk4yuibj	441	12	-	-	HYPH
cord-321868-xk4yuibj	441	13	Sall	Sall	NNP
cord-321868-xk4yuibj	441	14	fragment	fragment	NN
cord-321868-xk4yuibj	441	15	carry	carry	VBP
cord-321868-xk4yuibj	441	16	ing	ing	DT
cord-321868-xk4yuibj	441	17	LEUP	LEUP	NNP
cord-321868-xk4yuibj	441	18	using	use	VBG
cord-321868-xk4yuibj	441	19	the	the	DT
cord-321868-xk4yuibj	441	20	Sal	Sal	NNP
cord-321868-xk4yuibj	441	21	-	-	HYPH
cord-321868-xk4yuibj	441	22	downstream	downstream	NN
cord-321868-xk4yuibj	441	23	and	and	CC
cord-321868-xk4yuibj	441	24	ENX	enx	NN
cord-321868-xk4yuibj	441	25	-	-	HYPH
cord-321868-xk4yuibj	441	26	upstream	upstream	NN
cord-321868-xk4yuibj	441	27	primers	primer	NNS
cord-321868-xk4yuibj	441	28	(	(	-LRB-
cord-321868-xk4yuibj	441	29	see	see	VB
cord-321868-xk4yuibj	441	30	Table	Table	NNP
cord-321868-xk4yuibj	441	31	7	7	CD
cord-321868-xk4yuibj	441	32	)	)	-RRB-
cord-321868-xk4yuibj	441	33	.	.	.
cord-321868-xk4yuibj	442	1	The	the	DT
cord-321868-xk4yuibj	442	2	product	product	NN
cord-321868-xk4yuibj	442	3	was	be	VBD
cord-321868-xk4yuibj	442	4	a	a	DT
cord-321868-xk4yuibj	442	5	548	548	CD
cord-321868-xk4yuibj	442	6	bp	bp	NNP
cord-321868-xk4yuibj	442	7	fragment	fragment	NN
cord-321868-xk4yuibj	442	8	with	with	IN
cord-321868-xk4yuibj	442	9	EcoRI	EcoRI	NNP
cord-321868-xk4yuibj	442	10	,	,	,
cord-321868-xk4yuibj	442	11	Ndel	Ndel	NNP
cord-321868-xk4yuibj	442	12	,	,	,
cord-321868-xk4yuibj	442	13	and	and	CC
cord-321868-xk4yuibj	442	14	Xhol	Xhol	NNP
cord-321868-xk4yuibj	442	15	sites	site	NNS
cord-321868-xk4yuibj	442	16	at	at	IN
cord-321868-xk4yuibj	442	17	the	the	DT
cord-321868-xk4yuibj	442	18	upstream	upstream	JJ
cord-321868-xk4yuibj	442	19	end	end	NN
cord-321868-xk4yuibj	442	20	of	of	IN
cord-321868-xk4yuibj	442	21	the	the	DT
cord-321868-xk4yuibj	442	22	tRNA	tRNA	NNP
cord-321868-xk4yuibj	442	23	fragment	fragment	NN
cord-321868-xk4yuibj	442	24	and	and	CC
cord-321868-xk4yuibj	442	25	a	a	DT
cord-321868-xk4yuibj	442	26	Sall	Sall	NNP
cord-321868-xk4yuibj	442	27	site	site	NN
cord-321868-xk4yuibj	442	28	at	at	IN
cord-321868-xk4yuibj	442	29	the	the	DT
cord-321868-xk4yuibj	442	30	downstream	downstream	JJ
cord-321868-xk4yuibj	442	31	end	end	NN
cord-321868-xk4yuibj	442	32	.	.	.
cord-321868-xk4yuibj	443	1	Ndel	Ndel	NNP
cord-321868-xk4yuibj	443	2	-	-	HYPH
cord-321868-xk4yuibj	443	3	and	and	CC
cord-321868-xk4yuibj	443	4	Sallcleaved	Sallcleaved	NNP
cord-321868-xk4yuibj	443	5	fragment	fragment	NN
cord-321868-xk4yuibj	443	6	was	be	VBD
cord-321868-xk4yuibj	443	7	cloned	clone	VBN
cord-321868-xk4yuibj	443	8	into	into	IN
cord-321868-xk4yuibj	443	9	pUCl3	pucl3	NN
cord-321868-xk4yuibj	443	10	between	between	IN
cord-321868-xk4yuibj	443	11	the	the	DT
cord-321868-xk4yuibj	443	12	unique	unique	JJ
cord-321868-xk4yuibj	443	13	Ndel	Ndel	NNP
cord-321868-xk4yuibj	443	14	and	and	CC
cord-321868-xk4yuibj	443	15	Sall	Sall	NNP
cord-321868-xk4yuibj	443	16	sites	site	NNS
cord-321868-xk4yuibj	443	17	.	.	.
cord-321868-xk4yuibj	444	1	The	the	DT
cord-321868-xk4yuibj	444	2	resulting	result	VBG
cord-321868-xk4yuibj	444	3	clone	clone	NN
cord-321868-xk4yuibj	444	4	lacks	lack	VBZ
cord-321868-xk4yuibj	444	5	the	the	DT
cord-321868-xk4yuibj	444	6	unique	unique	JJ
cord-321868-xk4yuibj	444	7	Narl	Narl	NNP
cord-321868-xk4yuibj	444	8	site	site	NN
cord-321868-xk4yuibj	444	9	of	of	IN
cord-321868-xk4yuibj	444	10	pUC13	pUC13	NNS
cord-321868-xk4yuibj	444	11	,	,	,
cord-321868-xk4yuibj	444	12	but	but	CC
cord-321868-xk4yuibj	444	13	introduces	introduce	VBZ
cord-321868-xk4yuibj	444	14	a	a	DT
cord-321868-xk4yuibj	444	15	unique	unique	JJ
cord-321868-xk4yuibj	444	16	Narl	Narl	NNP
cord-321868-xk4yuibj	444	17	site	site	NN
cord-321868-xk4yuibj	444	18	in	in	IN
cord-321868-xk4yuibj	444	19	the	the	DT
cord-321868-xk4yuibj	444	20	insert	insert	NN
cord-321868-xk4yuibj	444	21	starting	start	VBG
cord-321868-xk4yuibj	444	22	11	11	CD
cord-321868-xk4yuibj	444	23	bp	bp	NNP
cord-321868-xk4yuibj	444	24	upstream	upstream	RB
cord-321868-xk4yuibj	444	25	of	of	IN
cord-321868-xk4yuibj	444	26	the	the	DT
cord-321868-xk4yuibj	444	27	anticodon	anticodon	NN
cord-321868-xk4yuibj	444	28	of	of	IN
cord-321868-xk4yuibj	444	29	tRNALgA.	tRNALgA.	NNP
cord-321868-xk4yuibj	445	1	To	to	TO
cord-321868-xk4yuibj	445	2	construct	construct	VB
cord-321868-xk4yuibj	445	3	the	the	DT
cord-321868-xk4yuibj	445	4	three	three	CD
cord-321868-xk4yuibj	445	5	codon	codon	NN
cord-321868-xk4yuibj	445	6	replacements	replacement	NNS
cord-321868-xk4yuibj	445	7	of	of	IN
cord-321868-xk4yuibj	445	8	tRNAL	trnal	NN
cord-321868-xk4yuibj	446	1	&	&	CC
cord-321868-xk4yuibj	446	2	,	,	,
cord-321868-xk4yuibj	446	3	we	-PRON-	PRP
cord-321868-xk4yuibj	446	4	adapted	adapt	VBD
cord-321868-xk4yuibj	446	5	a	a	DT
cord-321868-xk4yuibj	446	6	PCR	PCR	NNP
cord-321868-xk4yuibj	446	7	procedure	procedure	NN
cord-321868-xk4yuibj	446	8	in	in	IN
cord-321868-xk4yuibj	446	9	which	which	WDT
cord-321868-xk4yuibj	446	10	a	a	DT
cord-321868-xk4yuibj	446	11	whole	whole	JJ
cord-321868-xk4yuibj	446	12	plasmid	plasmid	NN
cord-321868-xk4yuibj	446	13	is	be	VBZ
cord-321868-xk4yuibj	446	14	amplified	amplify	VBN
cord-321868-xk4yuibj	446	15	using	use	VBG
cord-321868-xk4yuibj	446	16	two	two	CD
cord-321868-xk4yuibj	446	17	adjacent	adjacent	JJ
cord-321868-xk4yuibj	446	18	,	,	,
cord-321868-xk4yuibj	446	19	divergent	divergent	JJ
cord-321868-xk4yuibj	446	20	primers	primer	NNS
cord-321868-xk4yuibj	446	21	(	(	-LRB-
cord-321868-xk4yuibj	446	22	Hemsley	Hemsley	NNP
cord-321868-xk4yuibj	446	23	et	et	NNP
cord-321868-xk4yuibj	446	24	al	al	NNP
cord-321868-xk4yuibj	446	25	.	.	NNP
cord-321868-xk4yuibj	446	26	,	,	,
cord-321868-xk4yuibj	446	27	1989	1989	CD
cord-321868-xk4yuibj	446	28	)	)	-RRB-
cord-321868-xk4yuibj	446	29	.	.	.
cord-321868-xk4yuibj	447	1	The	the	DT
cord-321868-xk4yuibj	447	2	Narl	Narl	NNP
cord-321868-xk4yuibj	447	3	-	-	HYPH
cord-321868-xk4yuibj	447	4	opposite	opposite	JJ
cord-321868-xk4yuibj	447	5	strand	strand	NN
cord-321868-xk4yuibj	447	6	primer	primer	NN
cord-321868-xk4yuibj	447	7	(	(	-LRB-
cord-321868-xk4yuibj	447	8	Table	Table	NNP
cord-321868-xk4yuibj	447	9	7	7	CD
cord-321868-xk4yuibj	447	10	)	)	-RRB-
cord-321868-xk4yuibj	447	11	primes	prime	VBZ
cord-321868-xk4yuibj	447	12	synthesis	synthesis	NN
cord-321868-xk4yuibj	447	13	from	from	IN
cord-321868-xk4yuibj	447	14	the	the	DT
cord-321868-xk4yuibj	447	15	unique	unique	JJ
cord-321868-xk4yuibj	447	16	Narl	Narl	NNP
cord-321868-xk4yuibj	447	17	site	site	NN
cord-321868-xk4yuibj	447	18	in	in	IN
cord-321868-xk4yuibj	447	19	the	the	DT
cord-321868-xk4yuibj	447	20	direction	direction	NN
cord-321868-xk4yuibj	447	21	away	away	RB
cord-321868-xk4yuibj	447	22	from	from	IN
cord-321868-xk4yuibj	447	23	the	the	DT
cord-321868-xk4yuibj	447	24	tRNALgA	tRNALgA	NNP
cord-321868-xk4yuibj	447	25	anticodon	anticodon	NN
cord-321868-xk4yuibj	447	26	.	.	.
cord-321868-xk4yuibj	448	1	Three	three	CD
cord-321868-xk4yuibj	448	2	primers	primer	NNS
cord-321868-xk4yuibj	448	3	incorporating	incorporate	VBG
cord-321868-xk4yuibj	448	4	the	the	DT
cord-321868-xk4yuibj	448	5	novel	novel	JJ
cord-321868-xk4yuibj	448	6	anticodons	anticodon	NNS
cord-321868-xk4yuibj	448	7	,	,	,
cord-321868-xk4yuibj	448	8	the	the	DT
cord-321868-xk4yuibj	448	9	AAG	AAG	NNP
cord-321868-xk4yuibj	448	10	,	,	,
cord-321868-xk4yuibj	448	11	UAG	UAG	NNP
cord-321868-xk4yuibj	448	12	.	.	.
cord-321868-xk4yuibj	449	1	and	and	CC
cord-321868-xk4yuibj	449	2	AAU	AAU	NNP
cord-321868-xk4yuibj	449	3	primers	primer	NNS
cord-321868-xk4yuibj	449	4	(	(	-LRB-
cord-321868-xk4yuibj	449	5	Table	Table	NNP
cord-321868-xk4yuibj	449	6	 	 	_SP
cord-321868-xk4yuibj	449	7	3	3	CD
cord-321868-xk4yuibj	449	8	)	)	-RRB-
cord-321868-xk4yuibj	449	9	prime	prime	JJ
cord-321868-xk4yuibj	449	10	synthesis	synthesis	NN
cord-321868-xk4yuibj	449	11	from	from	IN
cord-321868-xk4yuibj	449	12	the	the	DT
cord-321868-xk4yuibj	449	13	Narl	Narl	NNP
cord-321868-xk4yuibj	449	14	site	site	NN
cord-321868-xk4yuibj	449	15	in	in	IN
cord-321868-xk4yuibj	449	16	the	the	DT
cord-321868-xk4yuibj	449	17	opposite	opposite	JJ
cord-321868-xk4yuibj	449	18	direction	direction	NN
cord-321868-xk4yuibj	449	19	.	.	.
cord-321868-xk4yuibj	450	1	The	the	DT
cord-321868-xk4yuibj	450	2	product	product	NN
cord-321868-xk4yuibj	450	3	is	be	VBZ
cord-321868-xk4yuibj	450	4	a	a	DT
cord-321868-xk4yuibj	450	5	linear	linear	JJ
cord-321868-xk4yuibj	450	6	form	form	NN
cord-321868-xk4yuibj	450	7	of	of	IN
cord-321868-xk4yuibj	450	8	the	the	DT
cord-321868-xk4yuibj	450	9	plasmid	plasmid	NN
cord-321868-xk4yuibj	450	10	with	with	IN
cord-321868-xk4yuibj	450	11	Narl	Narl	NNP
cord-321868-xk4yuibj	450	12	sites	site	NNS
cord-321868-xk4yuibj	450	13	at	at	IN
cord-321868-xk4yuibj	450	14	either	either	DT
cord-321868-xk4yuibj	450	15	end	end	NN
cord-321868-xk4yuibj	450	16	carrying	carry	VBG
cord-321868-xk4yuibj	450	17	the	the	DT
cord-321868-xk4yuibj	450	18	novel	novel	JJ
cord-321868-xk4yuibj	450	19	anticodons	anticodon	NNS
cord-321868-xk4yuibj	450	20	.	.	.
cord-321868-xk4yuibj	451	1	The	the	DT
cord-321868-xk4yuibj	451	2	product	product	NN
cord-321868-xk4yuibj	451	3	is	be	VBZ
cord-321868-xk4yuibj	451	4	digested	digest	VBN
cord-321868-xk4yuibj	451	5	with	with	IN
cord-321868-xk4yuibj	451	6	Narl	Narl	NNP
cord-321868-xk4yuibj	451	7	and	and	CC
cord-321868-xk4yuibj	451	8	recircularized	recircularize	VBN
cord-321868-xk4yuibj	451	9	to	to	TO
cord-321868-xk4yuibj	451	10	recover	recover	VB
cord-321868-xk4yuibj	451	11	the	the	DT
cord-321868-xk4yuibj	451	12	plasmids	plasmid	NNS
cord-321868-xk4yuibj	451	13	bearing	bear	VBG
cord-321868-xk4yuibj	451	14	the	the	DT
cord-321868-xk4yuibj	451	15	novel	novel	NN
cord-321868-xk4yuibj	451	16	tRNA	tRNA	NNP
cord-321868-xk4yuibj	451	17	genes	gene	NNS
cord-321868-xk4yuibj	451	18	.	.	.
cord-321868-xk4yuibj	452	1	The	the	DT
cord-321868-xk4yuibj	452	2	Xhol	Xhol	NNP
cord-321868-xk4yuibj	452	3	-	-	HYPH
cord-321868-xk4yuibj	452	4	Sal1	Sal1	NNP
cord-321868-xk4yuibj	452	5	fragment	fragment	NN
cord-321868-xk4yuibj	452	6	encompassing	encompass	VBG
cord-321868-xk4yuibj	452	7	each	each	DT
cord-321868-xk4yuibj	452	8	gene	gene	NN
cord-321868-xk4yuibj	452	9	was	be	VBD
cord-321868-xk4yuibj	452	10	transferred	transfer	VBN
cord-321868-xk4yuibj	452	11	into	into	IN
cord-321868-xk4yuibj	452	12	the	the	DT
cord-321868-xk4yuibj	452	13	Sal1	Sal1	NNP
cord-321868-xk4yuibj	452	14	site	site	NN
cord-321868-xk4yuibj	452	15	of	of	IN
cord-321868-xk4yuibj	452	16	pMB38	pMB38	NNS
cord-321868-xk4yuibj	452	17	-	-	HYPH
cord-321868-xk4yuibj	452	18	9merWT	9merwt	CD
cord-321868-xk4yuibj	452	19	and	and	CC
cord-321868-xk4yuibj	452	20	isolates	isolate	NNS
cord-321868-xk4yuibj	452	21	of	of	IN
cord-321868-xk4yuibj	452	22	each	each	DT
cord-321868-xk4yuibj	452	23	in	in	IN
cord-321868-xk4yuibj	452	24	which	which	WDT
cord-321868-xk4yuibj	452	25	the	the	DT
cord-321868-xk4yuibj	452	26	tRNA	tRNA	NNP
cord-321868-xk4yuibj	452	27	gene	gene	NN
cord-321868-xk4yuibj	452	28	is	be	VBZ
cord-321868-xk4yuibj	452	29	oriented	orient	VBN
cord-321868-xk4yuibj	452	30	pointing	point	VBG
cord-321868-xk4yuibj	452	31	toward	toward	IN
cord-321868-xk4yuibj	452	32	the	the	DT
cord-321868-xk4yuibj	452	33	3'end	3'end	CD
cord-321868-xk4yuibj	452	34	of	of	IN
cord-321868-xk4yuibj	452	35	the	the	DT
cord-321868-xk4yuibj	452	36	/acZ	/acZ	NNP
cord-321868-xk4yuibj	452	37	gene	gene	NN
cord-321868-xk4yuibj	452	38	of	of	IN
cord-321868-xk4yuibj	452	39	the	the	DT
cord-321868-xk4yuibj	452	40	plasmid	plasmid	NN
cord-321868-xk4yuibj	452	41	were	be	VBD
cord-321868-xk4yuibj	452	42	selected	select	VBN
cord-321868-xk4yuibj	452	43	.	.	.
cord-321868-xk4yuibj	453	1	These	these	DT
cord-321868-xk4yuibj	453	2	plasmids	plasmid	NNS
cord-321868-xk4yuibj	453	3	are	be	VBP
cord-321868-xk4yuibj	453	4	pMB38-SmerWT	pMB38-SmerWT	NNP
cord-321868-xk4yuibj	453	5	-	-	HYPH
cord-321868-xk4yuibj	453	6	tRNA	tRNA	NNP
cord-321868-xk4yuibj	453	7	&	&	CC
cord-321868-xk4yuibj	453	8	&	&	CC
cord-321868-xk4yuibj	453	9	pMB38-SmerWT	pMB38-SmerWT	NNP
cord-321868-xk4yuibj	453	10	-	-	HYPH
cord-321868-xk4yuibj	453	11	tRNAt	tRNAt	NNPS
cord-321868-xk4yuibj	453	12	&	&	CC
cord-321868-xk4yuibj	453	13	,	,	,
cord-321868-xk4yuibj	453	14	and	and	CC
cord-321868-xk4yuibj	453	15	pMB3&9merWT	pMB3&9merWT	NNP
cord-321868-xk4yuibj	453	16	-	-	HYPH
cord-321868-xk4yuibj	453	17	tRNA	tRNA	NNP
cord-321868-xk4yuibj	453	18	&	&	CC
cord-321868-xk4yuibj	453	19	pGalactosidase	pGalactosidase	NNP
cord-321868-xk4yuibj	453	20	Purification	Purification	NNP
cord-321868-xk4yuibj	453	21	and	and	CC
cord-321868-xk4yuibj	453	22	Protein	Protein	NNP
cord-321868-xk4yuibj	453	23	Sequencing	Sequencing	NNP
cord-321868-xk4yuibj	454	1	The	the	DT
cord-321868-xk4yuibj	454	2	protocol	protocol	NN
cord-321868-xk4yuibj	454	3	for	for	IN
cord-321868-xk4yuibj	454	4	p	p	NN
cord-321868-xk4yuibj	454	5	-	-	HYPH
cord-321868-xk4yuibj	454	6	galactosidase	galactosidase	NN
cord-321868-xk4yuibj	454	7	purification	purification	NN
cord-321868-xk4yuibj	454	8	from	from	IN
cord-321868-xk4yuibj	454	9	yeast	yeast	NN
cord-321868-xk4yuibj	454	10	was	be	VBD
cord-321868-xk4yuibj	454	11	provided	provide	VBN
cord-321868-xk4yuibj	454	12	by	by	IN
cord-321868-xk4yuibj	454	13	Robert	Robert	NNP
cord-321868-xk4yuibj	454	14	Weiss	Weiss	NNP
cord-321868-xk4yuibj	454	15	and	and	CC
cord-321868-xk4yuibj	454	16	is	be	VBZ
cord-321868-xk4yuibj	454	17	essentially	essentially	RB
cord-321868-xk4yuibj	454	18	as	as	IN
cord-321868-xk4yuibj	454	19	described	describe	VBN
cord-321868-xk4yuibj	454	20	(	(	-LRB-
cord-321868-xk4yuibj	454	21	Weiss	Weiss	NNP
cord-321868-xk4yuibj	454	22	et	et	NNP
cord-321868-xk4yuibj	454	23	al	al	NNP
cord-321868-xk4yuibj	454	24	.	.	NNP
cord-321868-xk4yuibj	454	25	,	,	,
cord-321868-xk4yuibj	454	26	1989	1989	CD
cord-321868-xk4yuibj	454	27	)	)	-RRB-
cord-321868-xk4yuibj	454	28	.	.	.
cord-321868-xk4yuibj	455	1	Yeast	yeast	NN
cord-321868-xk4yuibj	455	2	strain	strain	NN
cord-321868-xk4yuibj	455	3	387-lD	387-ld	CD
cord-321868-xk4yuibj	455	4	,	,	,
cord-321868-xk4yuibj	455	5	transformed	transform	VBN
cord-321868-xk4yuibj	455	6	with	with	IN
cord-321868-xk4yuibj	455	7	plasmid	plasmid	NN
cord-321868-xk4yuibj	456	1	p3p-9merWT	p3p-9merWT	NNP
cord-321868-xk4yuibj	456	2	.	.	.
cord-321868-xk4yuibj	456	3	was	be	VBD
cord-321868-xk4yuibj	456	4	grown	grow	VBN
cord-321868-xk4yuibj	456	5	at	at	IN
cord-321868-xk4yuibj	456	6	30	30	CD
cord-321868-xk4yuibj	456	7	%	%	NN
cord-321868-xk4yuibj	456	8	in	in	IN
cord-321868-xk4yuibj	456	9	18	18	CD
cord-321868-xk4yuibj	456	10	liters	liter	NNS
cord-321868-xk4yuibj	456	11	of	of	IN
cord-321868-xk4yuibj	456	12	SD	sd	NN
cord-321868-xk4yuibj	456	13	minimal	minimal	JJ
cord-321868-xk4yuibj	456	14	medium	medium	NN
cord-321868-xk4yuibj	456	15	supplemented	supplement	VBN
cord-321868-xk4yuibj	456	16	with	with	IN
cord-321868-xk4yuibj	456	17	20	20	CD
cord-321868-xk4yuibj	456	18	mgll	mgll	NNS
cord-321868-xk4yuibj	456	19	of	of	IN
cord-321868-xk4yuibj	456	20	histidine	histidine	NN
cord-321868-xk4yuibj	456	21	and	and	CC
cord-321868-xk4yuibj	456	22	tryptophan	tryptophan	NN
cord-321868-xk4yuibj	456	23	and	and	CC
cord-321868-xk4yuibj	456	24	2	2	CD
cord-321868-xk4yuibj	456	25	%	%	NN
cord-321868-xk4yuibj	456	26	glucose	glucose	NN
cord-321868-xk4yuibj	456	27	.	.	.
cord-321868-xk4yuibj	457	1	At	at	IN
cord-321868-xk4yuibj	457	2	a	a	DT
cord-321868-xk4yuibj	457	3	culture	culture	NN
cord-321868-xk4yuibj	457	4	density	density	NN
cord-321868-xk4yuibj	457	5	of	of	IN
cord-321868-xk4yuibj	457	6	~'&I	~'&i	NN
cord-321868-xk4yuibj	457	7	=	=	SYM
cord-321868-xk4yuibj	457	8	1	1	CD
cord-321868-xk4yuibj	457	9	,	,	,
cord-321868-xk4yuibj	457	10	the	the	DT
cord-321868-xk4yuibj	457	11	cells	cell	NNS
cord-321868-xk4yuibj	457	12	were	be	VBD
cord-321868-xk4yuibj	457	13	pelleted	pellete	VBN
cord-321868-xk4yuibj	457	14	,	,	,
cord-321868-xk4yuibj	457	15	washed	wash	VBN
cord-321868-xk4yuibj	457	16	with	with	IN
cord-321868-xk4yuibj	457	17	one	one	CD
cord-321868-xk4yuibj	457	18	-	-	HYPH
cord-321868-xk4yuibj	457	19	fourth	fourth	JJ
cord-321868-xk4yuibj	457	20	volume	volume	NN
cord-321868-xk4yuibj	457	21	of	of	IN
cord-321868-xk4yuibj	457	22	buffer	buffer	NN
cord-321868-xk4yuibj	457	23	A	a	NN
cord-321868-xk4yuibj	457	24	(	(	-LRB-
cord-321868-xk4yuibj	457	25	50	50	CD
cord-321868-xk4yuibj	457	26	mM	mM	NNP
cord-321868-xk4yuibj	457	27	Tris	Tris	NNP
cord-321868-xk4yuibj	457	28	-	-	HYPH
cord-321868-xk4yuibj	457	29	HCI	HCI	NNP
cord-321868-xk4yuibj	457	30	[	[	-LRB-
cord-321868-xk4yuibj	457	31	pH	pH	NNP
cord-321868-xk4yuibj	457	32	7.41	7.41	CD
cord-321868-xk4yuibj	457	33	,	,	,
cord-321868-xk4yuibj	457	34	150	150	CD
cord-321868-xk4yuibj	457	35	mM	mm	CD
cord-321868-xk4yuibj	457	36	NaCI	naci	NN
cord-321868-xk4yuibj	457	37	,	,	,
cord-321868-xk4yuibj	457	38	5	5	CD
cord-321868-xk4yuibj	457	39	mM	mm	CD
cord-321868-xk4yuibj	457	40	EDTA	EDTA	NNP
cord-321868-xk4yuibj	457	41	.	.	.
cord-321868-xk4yuibj	458	1	0.1	0.1	CD
cord-321868-xk4yuibj	458	2	%	%	NN
cord-321868-xk4yuibj	458	3	Tween	Tween	NNP
cord-321868-xk4yuibj	458	4	20	20	CD
cord-321868-xk4yuibj	458	5	,	,	,
cord-321868-xk4yuibj	458	6	10	10	CD
cord-321868-xk4yuibj	458	7	mM	mm	CD
cord-321868-xk4yuibj	458	8	&	&	CC
cord-321868-xk4yuibj	458	9	mercaptoethanol	mercaptoethanol	NNP
cord-321868-xk4yuibj	458	10	,	,	,
cord-321868-xk4yuibj	458	11	and	and	CC
cord-321868-xk4yuibj	458	12	0.5	0.5	CD
cord-321868-xk4yuibj	458	13	mM	mm	CD
cord-321868-xk4yuibj	458	14	PMSF	PMSF	NNP
cord-321868-xk4yuibj	458	15	)	)	-RRB-
cord-321868-xk4yuibj	458	16	,	,	,
cord-321868-xk4yuibj	458	17	and	and	CC
cord-321868-xk4yuibj	458	18	then	then	RB
cord-321868-xk4yuibj	458	19	resuspended	resuspend	VBD
cord-321868-xk4yuibj	458	20	in	in	IN
cord-321868-xk4yuibj	458	21	the	the	DT
cord-321868-xk4yuibj	458	22	same	same	JJ
cord-321868-xk4yuibj	458	23	buffer	buffer	NN
cord-321868-xk4yuibj	458	24	(	(	-LRB-
cord-321868-xk4yuibj	458	25	3	3	CD
cord-321868-xk4yuibj	458	26	ml	ml	NN
cord-321868-xk4yuibj	458	27	of	of	IN
cord-321868-xk4yuibj	458	28	buffer	buffer	NN
cord-321868-xk4yuibj	458	29	per	per	IN
cord-321868-xk4yuibj	458	30	gram	gram	NN
cord-321868-xk4yuibj	458	31	of	of	IN
cord-321868-xk4yuibj	458	32	cells	cell	NNS
cord-321868-xk4yuibj	458	33	)	)	-RRB-
cord-321868-xk4yuibj	458	34	.	.	.
cord-321868-xk4yuibj	459	1	Cells	cell	NNS
cord-321868-xk4yuibj	459	2	were	be	VBD
cord-321868-xk4yuibj	459	3	broken	break	VBN
cord-321868-xk4yuibj	459	4	using	use	VBG
cord-321868-xk4yuibj	459	5	10	10	CD
cord-321868-xk4yuibj	459	6	g	g	NN
cord-321868-xk4yuibj	459	7	of	of	IN
cord-321868-xk4yuibj	459	8	400	400	CD
cord-321868-xk4yuibj	459	9	urn	urn	NN
cord-321868-xk4yuibj	459	10	glass	glass	NN
cord-321868-xk4yuibj	459	11	beads	bead	NNS
cord-321868-xk4yuibj	459	12	(	(	-LRB-
cord-321868-xk4yuibj	459	13	Sigma	Sigma	NNP
cord-321868-xk4yuibj	459	14	)	)	-RRB-
cord-321868-xk4yuibj	459	15	per	per	IN
cord-321868-xk4yuibj	459	16	4	4	CD
cord-321868-xk4yuibj	459	17	ml	ml	NNS
cord-321868-xk4yuibj	459	18	of	of	IN
cord-321868-xk4yuibj	459	19	suspension	suspension	NN
cord-321868-xk4yuibj	459	20	by	by	IN
cord-321868-xk4yuibj	459	21	vortexing	vortexe	VBG
cord-321868-xk4yuibj	459	22	for	for	IN
cord-321868-xk4yuibj	459	23	4	4	CD
cord-321868-xk4yuibj	459	24	min	min	NN
cord-321868-xk4yuibj	459	25	with	with	IN
cord-321868-xk4yuibj	459	26	1	1	CD
cord-321868-xk4yuibj	459	27	min	min	NNP
cord-321868-xk4yuibj	459	28	incubations	incubation	NNS
cord-321868-xk4yuibj	459	29	on	on	IN
cord-321868-xk4yuibj	459	30	ice	ice	NN
cord-321868-xk4yuibj	459	31	between	between	IN
cord-321868-xk4yuibj	459	32	each	each	DT
cord-321868-xk4yuibj	459	33	minute	minute	NN
cord-321868-xk4yuibj	459	34	of	of	IN
cord-321868-xk4yuibj	459	35	vortexing	vortexing	NN
cord-321868-xk4yuibj	459	36	.	.	.
cord-321868-xk4yuibj	460	1	Cell	cell	NN
cord-321868-xk4yuibj	460	2	debris	debris	NN
cord-321868-xk4yuibj	460	3	and	and	CC
cord-321868-xk4yuibj	460	4	beads	bead	NNS
cord-321868-xk4yuibj	460	5	were	be	VBD
cord-321868-xk4yuibj	460	6	pelleted	pellete	VBN
cord-321868-xk4yuibj	460	7	by	by	IN
cord-321868-xk4yuibj	460	8	centrifugation	centrifugation	NN
cord-321868-xk4yuibj	460	9	at	at	IN
cord-321868-xk4yuibj	460	10	2000	2000	CD
cord-321868-xk4yuibj	460	11	x	x	SYM
cord-321868-xk4yuibj	460	12	g	g	NN
cord-321868-xk4yuibj	460	13	for	for	IN
cord-321868-xk4yuibj	460	14	15	15	CD
cord-321868-xk4yuibj	460	15	min	min	NN
cord-321868-xk4yuibj	460	16	.	.	.
cord-321868-xk4yuibj	461	1	The	the	DT
cord-321868-xk4yuibj	461	2	resulting	result	VBG
cord-321868-xk4yuibj	461	3	supernatant	supernatant	NN
cord-321868-xk4yuibj	461	4	was	be	VBD
cord-321868-xk4yuibj	461	5	then	then	RB
cord-321868-xk4yuibj	461	6	centrifuged	centrifuge	VBN
cord-321868-xk4yuibj	461	7	for	for	IN
cord-321868-xk4yuibj	461	8	90	90	CD
cord-321868-xk4yuibj	461	9	min	min	NN
cord-321868-xk4yuibj	461	10	at	at	IN
cord-321868-xk4yuibj	461	11	100,000	100,000	CD
cord-321868-xk4yuibj	461	12	x	x	SYM
cord-321868-xk4yuibj	461	13	g	g	NN
cord-321868-xk4yuibj	461	14	in	in	IN
cord-321868-xk4yuibj	461	15	a	a	DT
cord-321868-xk4yuibj	461	16	Beckman	Beckman	NNP
cord-321868-xk4yuibj	461	17	TLlOO	TLlOO	NNP
cord-321868-xk4yuibj	461	18	centrifuge	centrifuge	NN
cord-321868-xk4yuibj	461	19	to	to	IN
cord-321868-xk4yuibj	461	20	pellet	pellet	NN
cord-321868-xk4yuibj	461	21	organelles	organelle	NNS
cord-321868-xk4yuibj	461	22	.	.	.
cord-321868-xk4yuibj	462	1	A	a	DT
cord-321868-xk4yuibj	462	2	clear	clear	JJ
cord-321868-xk4yuibj	462	3	supernatant	supernatant	NN
cord-321868-xk4yuibj	462	4	was	be	VBD
cord-321868-xk4yuibj	462	5	collected	collect	VBN
cord-321868-xk4yuibj	462	6	and	and	CC
cord-321868-xk4yuibj	462	7	passed	pass	VBN
cord-321868-xk4yuibj	462	8	over	over	RP
cord-321868-xk4yuibj	462	9	an	an	DT
cord-321868-xk4yuibj	462	10	anti+-galactosidase	anti+-galactosidase	NNP
cord-321868-xk4yuibj	462	11	immunoaffinity	immunoaffinity	NN
cord-321868-xk4yuibj	462	12	column	column	NN
cord-321868-xk4yuibj	462	13	(	(	-LRB-
cord-321868-xk4yuibj	462	14	Protosorb	Protosorb	NNP
cord-321868-xk4yuibj	462	15	,	,	,
cord-321868-xk4yuibj	462	16	Promega	Promega	NNP
cord-321868-xk4yuibj	462	17	Biotec	Biotec	NNP
cord-321868-xk4yuibj	462	18	)	)	-RRB-
cord-321868-xk4yuibj	462	19	equilibrated	equilibrate	VBN
cord-321868-xk4yuibj	462	20	with	with	IN
cord-321868-xk4yuibj	462	21	buffer	buffer	NN
cord-321868-xk4yuibj	462	22	A.	a.	NN
cord-321868-xk4yuibj	463	1	The	the	DT
cord-321868-xk4yuibj	463	2	eluate	eluate	NN
cord-321868-xk4yuibj	463	3	was	be	VBD
cord-321868-xk4yuibj	463	4	concentrated	concentrate	VBN
cord-321868-xk4yuibj	463	5	with	with	IN
cord-321868-xk4yuibj	463	6	a	a	DT
cord-321868-xk4yuibj	463	7	Centricon	Centricon	NNP
cord-321868-xk4yuibj	463	8	30	30	CD
cord-321868-xk4yuibj	463	9	centrifuge	centrifuge	NN
cord-321868-xk4yuibj	463	10	chamber	chamber	NN
cord-321868-xk4yuibj	463	11	(	(	-LRB-
cord-321868-xk4yuibj	463	12	Amicon	Amicon	NNP
cord-321868-xk4yuibj	463	13	)	)	-RRB-
cord-321868-xk4yuibj	463	14	,	,	,
cord-321868-xk4yuibj	463	15	washed	wash	VBD
cord-321868-xk4yuibj	463	16	four	four	CD
cord-321868-xk4yuibj	463	17	times	time	NNS
cord-321868-xk4yuibj	463	18	with	with	IN
cord-321868-xk4yuibj	463	19	HPLC	HPLC	NNP
cord-321868-xk4yuibj	463	20	-	-	HYPH
cord-321868-xk4yuibj	463	21	grade	grade	NN
cord-321868-xk4yuibj	463	22	water	water	NN
cord-321868-xk4yuibj	463	23	,	,	,
cord-321868-xk4yuibj	463	24	and	and	CC
cord-321868-xk4yuibj	463	25	then	then	RB
cord-321868-xk4yuibj	463	26	placed	place	VBN
cord-321868-xk4yuibj	463	27	in	in	IN
cord-321868-xk4yuibj	463	28	the	the	DT
cord-321868-xk4yuibj	463	29	cartridge	cartridge	NN
cord-321868-xk4yuibj	463	30	of	of	IN
cord-321868-xk4yuibj	463	31	an	an	DT
cord-321868-xk4yuibj	463	32	Applied	Applied	NNP
cord-321868-xk4yuibj	463	33	Biosystems	Biosystems	NNP
cord-321868-xk4yuibj	463	34	475A	475a	CD
cord-321868-xk4yuibj	463	35	protein	protein	NN
cord-321868-xk4yuibj	463	36	sequencer	sequencer	NN
cord-321868-xk4yuibj	463	37	equipped	equip	VBN
cord-321868-xk4yuibj	463	38	with	with	IN
cord-321868-xk4yuibj	463	39	an	an	DT
cord-321868-xk4yuibj	463	40	on	on	IN
cord-321868-xk4yuibj	463	41	-	-	HYPH
cord-321868-xk4yuibj	463	42	line	line	NN
cord-321868-xk4yuibj	463	43	Applied	Applied	NNP
cord-321868-xk4yuibj	463	44	Biosystems	Biosystems	NNP
cord-321868-xk4yuibj	463	45	120A	120A	NNP
cord-321868-xk4yuibj	463	46	high	high	JJ
cord-321868-xk4yuibj	463	47	performance	performance	NN
cord-321868-xk4yuibj	463	48	liquid	liquid	NN
cord-321868-xk4yuibj	463	49	chromatography	chromatography	NN
cord-321868-xk4yuibj	463	50	analyzer	analyzer	NN
cord-321868-xk4yuibj	463	51	.	.	.
cord-321868-xk4yuibj	463	52	!	!	.
cord-321868-xk4yuibj	464	1	3-Galactosidase	3-Galactosidase	NNP
cord-321868-xk4yuibj	464	2	Assay	Assay	NNP
cord-321868-xk4yuibj	464	3	and	and	CC
cord-321868-xk4yuibj	464	4	DNA	DNA	NNP
cord-321868-xk4yuibj	465	1	Sequencing	sequence	VBG
cord-321868-xk4yuibj	465	2	Three	three	CD
cord-321868-xk4yuibj	465	3	transformants	transformant	NNS
cord-321868-xk4yuibj	465	4	of	of	IN
cord-321868-xk4yuibj	465	5	each	each	DT
cord-321868-xk4yuibj	465	6	plasmid	plasmid	NN
cord-321868-xk4yuibj	465	7	were	be	VBD
cord-321868-xk4yuibj	465	8	each	each	DT
cord-321868-xk4yuibj	465	9	assayed	assay	VBN
cord-321868-xk4yuibj	465	10	in	in	IN
cord-321868-xk4yuibj	465	11	triplicate	triplicate	NN
cord-321868-xk4yuibj	465	12	for	for	IN
cord-321868-xk4yuibj	465	13	f%galactosidase	f%galactosidase	NN
cord-321868-xk4yuibj	465	14	activity	activity	NN
cord-321868-xk4yuibj	465	15	as	as	IN
cord-321868-xk4yuibj	465	16	described	describe	VBN
cord-321868-xk4yuibj	465	17	(	(	-LRB-
cord-321868-xk4yuibj	465	18	Farabaugh	Farabaugh	NNP
cord-321868-xk4yuibj	465	19	et	et	FW
cord-321868-xk4yuibj	465	20	al	al	NNP
cord-321868-xk4yuibj	465	21	.	.	NNP
cord-321868-xk4yuibj	465	22	,	,	,
cord-321868-xk4yuibj	465	23	1989	1989	CD
cord-321868-xk4yuibj	465	24	)	)	-RRB-
cord-321868-xk4yuibj	465	25	.	.	.
cord-321868-xk4yuibj	466	1	All	all	DT
cord-321868-xk4yuibj	466	2	constructionsdescribed	constructionsdescribe	VBD
cord-321868-xk4yuibj	466	3	in	in	IN
cord-321868-xk4yuibj	466	4	this	this	DT
cord-321868-xk4yuibj	466	5	paper	paper	NN
cord-321868-xk4yuibj	466	6	were	be	VBD
cord-321868-xk4yuibj	466	7	sequenced	sequence	VBN
cord-321868-xk4yuibj	466	8	by	by	IN
cord-321868-xk4yuibj	466	9	the	the	DT
cord-321868-xk4yuibj	466	10	chain	chain	NN
cord-321868-xk4yuibj	466	11	termination	termination	NN
cord-321868-xk4yuibj	466	12	technique	technique	NN
cord-321868-xk4yuibj	466	13	(	(	-LRB-
cord-321868-xk4yuibj	466	14	Sanger	Sanger	NNP
cord-321868-xk4yuibj	466	15	et	et	NNP
cord-321868-xk4yuibj	466	16	al	al	NNP
cord-321868-xk4yuibj	466	17	.	.	NNP
cord-321868-xk4yuibj	466	18	,	,	,
cord-321868-xk4yuibj	466	19	1977	1977	CD
cord-321868-xk4yuibj	466	20	)	)	-RRB-
cord-321868-xk4yuibj	466	21	from	from	IN
cord-321868-xk4yuibj	466	22	plasmids	plasmid	NNS
cord-321868-xk4yuibj	466	23	prepared	prepare	VBN
cord-321868-xk4yuibj	466	24	as	as	IN
cord-321868-xk4yuibj	466	25	described	describe	VBN
cord-321868-xk4yuibj	466	26	by	by	IN
cord-321868-xk4yuibj	466	27	Mierendorf	Mierendorf	NNP
cord-321868-xk4yuibj	466	28	and	and	CC
cord-321868-xk4yuibj	466	29	Pfeffer	Pfeffer	NNP
cord-321868-xk4yuibj	466	30	(	(	-LRB-
cord-321868-xk4yuibj	466	31	1987	1987	CD
cord-321868-xk4yuibj	466	32	)	)	-RRB-
cord-321868-xk4yuibj	466	33	.	.	.
cord-321868-xk4yuibj	467	1	We	-PRON-	PRP
cord-321868-xk4yuibj	467	2	are	be	VBP
cord-321868-xk4yuibj	467	3	grateful	grateful	JJ
cord-321868-xk4yuibj	467	4	to	to	IN
cord-321868-xk4yuibj	467	5	Robert	Robert	NNP
cord-321868-xk4yuibj	467	6	Weiss	Weiss	NNP
cord-321868-xk4yuibj	467	7	for	for	IN
cord-321868-xk4yuibj	467	8	providing	provide	VBG
cord-321868-xk4yuibj	467	9	us	-PRON-	PRP
cord-321868-xk4yuibj	467	10	with	with	IN
cord-321868-xk4yuibj	467	11	the	the	DT
cord-321868-xk4yuibj	467	12	protocol	protocol	NN
cord-321868-xk4yuibj	467	13	for	for	IN
cord-321868-xk4yuibj	467	14	j%galactosidase	j%galactosidase	NN
cord-321868-xk4yuibj	467	15	purification	purification	NN
cord-321868-xk4yuibj	467	16	from	from	IN
cord-321868-xk4yuibj	467	17	yeast	yeast	NN
cord-321868-xk4yuibj	467	18	and	and	CC
cord-321868-xk4yuibj	467	19	for	for	IN
cord-321868-xk4yuibj	467	20	sequencing	sequence	VBG
cord-321868-xk4yuibj	467	21	the	the	DT
cord-321868-xk4yuibj	467	22	frameshift	frameshift	NN
cord-321868-xk4yuibj	467	23	protein	protein	NN
cord-321868-xk4yuibj	467	24	.	.	.
cord-321868-xk4yuibj	468	1	We	-PRON-	PRP
cord-321868-xk4yuibj	468	2	thank	thank	VBP
cord-321868-xk4yuibj	468	3	i	i	PRP
cord-321868-xk4yuibj	468	4	?	?	.
cord-321868-xk4yuibj	469	1	Philippsen	Philippsen	NNP
cord-321868-xk4yuibj	469	2	,	,	,
cord-321868-xk4yuibj	469	3	M.	M.	NNP
cord-321868-xk4yuibj	469	4	Olson	Olson	NNP
cord-321868-xk4yuibj	469	5	,	,	,
cord-321868-xk4yuibj	469	6	and	and	CC
cord-321868-xk4yuibj	469	7	G.	G.	NNP
cord-321868-xk4yuibj	469	8	Fink	Fink	NNP
cord-321868-xk4yuibj	469	9	for	for	IN
cord-321868-xk4yuibj	469	10	providing	provide	VBG
cord-321868-xk4yuibj	469	11	the	the	DT
cord-321868-xk4yuibj	469	12	clones	clone	NNS
cord-321868-xk4yuibj	469	13	and	and	CC
cord-321868-xk4yuibj	469	14	yeast	yeast	NN
cord-321868-xk4yuibj	469	15	strains	strain	NNS
cord-321868-xk4yuibj	469	16	indicated	indicate	VBN
cord-321868-xk4yuibj	469	17	above	above	RB
cord-321868-xk4yuibj	469	18	.	.	.
cord-321868-xk4yuibj	470	1	This	this	DT
cord-321868-xk4yuibj	470	2	work	work	NN
cord-321868-xk4yuibj	470	3	was	be	VBD
cord-321868-xk4yuibj	470	4	supported	support	VBN
cord-321868-xk4yuibj	470	5	by	by	IN
cord-321868-xk4yuibj	470	6	U.S.	U.S.	NNP
cord-321868-xk4yuibj	470	7	Public	Public	NNP
cord-321868-xk4yuibj	470	8	Health	Health	NNP
cord-321868-xk4yuibj	470	9	Service	Service	NNP
cord-321868-xk4yuibj	470	10	grant	grant	NN
cord-321868-xk4yuibj	470	11	GM	GM	NNP
cord-321868-xk4yuibj	470	12	29480	29480	CD
cord-321868-xk4yuibj	470	13	.	.	.
cord-321868-xk4yuibj	471	1	The	the	DT
cord-321868-xk4yuibj	471	2	costs	cost	NNS
cord-321868-xk4yuibj	471	3	of	of	IN
cord-321868-xk4yuibj	471	4	publication	publication	NN
cord-321868-xk4yuibj	471	5	of	of	IN
cord-321868-xk4yuibj	471	6	this	this	DT
cord-321868-xk4yuibj	471	7	article	article	NN
cord-321868-xk4yuibj	471	8	were	be	VBD
cord-321868-xk4yuibj	471	9	defrayed	defray	VBN
cord-321868-xk4yuibj	471	10	in	in	IN
cord-321868-xk4yuibj	471	11	part	part	NN
cord-321868-xk4yuibj	471	12	by	by	IN
cord-321868-xk4yuibj	471	13	the	the	DT
cord-321868-xk4yuibj	471	14	payment	payment	NN
cord-321868-xk4yuibj	471	15	of	of	IN
cord-321868-xk4yuibj	471	16	page	page	NN
cord-321868-xk4yuibj	471	17	charges	charge	NNS
cord-321868-xk4yuibj	471	18	.	.	.
cord-321868-xk4yuibj	472	1	This	this	DT
cord-321868-xk4yuibj	472	2	article	article	NN
cord-321868-xk4yuibj	472	3	must	must	MD
cord-321868-xk4yuibj	472	4	therefore	therefore	RB
cord-321868-xk4yuibj	472	5	be	be	VB
cord-321868-xk4yuibj	472	6	hereby	hereby	RB
cord-321868-xk4yuibj	472	7	marked	mark	VBN
cord-321868-xk4yuibj	472	8	"	"	``
cord-321868-xk4yuibj	472	9	advertisement	advertisement	NN
cord-321868-xk4yuibj	472	10	"	"	''
cord-321868-xk4yuibj	472	11	in	in	IN
cord-321868-xk4yuibj	472	12	accordance	accordance	NN
cord-321868-xk4yuibj	472	13	with	with	IN
cord-321868-xk4yuibj	472	14	18	18	CD
cord-321868-xk4yuibj	472	15	U.S.C.	U.S.C.	NNP
cord-321868-xk4yuibj	472	16	Section	Section	NNP
cord-321868-xk4yuibj	472	17	1734	1734	CD
cord-321868-xk4yuibj	472	18	solely	solely	RB
cord-321868-xk4yuibj	472	19	to	to	TO
cord-321868-xk4yuibj	472	20	indicate	indicate	VB
cord-321868-xk4yuibj	472	21	this	this	DT
cord-321868-xk4yuibj	472	22	fact	fact	NN
cord-321868-xk4yuibj	472	23	.	.	.
cord-321868-xk4yuibj	473	1	Received	receive	VBN
cord-321868-xk4yuibj	473	2	April	April	NNP
cord-321868-xk4yuibj	473	3	6	6	CD
cord-321868-xk4yuibj	473	4	,	,	,
cord-321868-xk4yuibj	473	5	1990	1990	CD
cord-321868-xk4yuibj	473	6	;	;	,
cord-321868-xk4yuibj	473	7	revised	revise	VBN
cord-321868-xk4yuibj	473	8	May	May	NNP
cord-321868-xk4yuibj	473	9	9	9	CD
cord-321868-xk4yuibj	473	10	,	,	,
cord-321868-xk4yuibj	473	11	1990	1990	CD
cord-321868-xk4yuibj	473	12	.	.	.
cord-321868-xk4yuibj	473	13	 	 	_SP
cord-321868-xk4yuibj	474	1	The	the	DT
cord-321868-xk4yuibj	474	2	functions	function	NNS
cord-321868-xk4yuibj	474	3	and	and	CC
cord-321868-xk4yuibj	474	4	relationships	relationship	NNS
cord-321868-xk4yuibj	474	5	of	of	IN
cord-321868-xk4yuibj	474	6	Ty	Ty	NNP
cord-321868-xk4yuibj	474	7	-	-	HYPH
cord-321868-xk4yuibj	474	8	VLP	VLP	NNP
cord-321868-xk4yuibj	474	9	proteins	protein	NNS
cord-321868-xk4yuibj	474	10	in	in	IN
cord-321868-xk4yuibj	474	11	yeast	yeast	NN
cord-321868-xk4yuibj	474	12	reflect	reflect	VBP
cord-321868-xk4yuibj	474	13	those	those	DT
cord-321868-xk4yuibj	474	14	of	of	IN
cord-321868-xk4yuibj	474	15	mammalian	mammalian	JJ
cord-321868-xk4yuibj	474	16	retroviral	retroviral	NN
cord-321868-xk4yuibj	474	17	proteins	protein	NNS
cord-321868-xk4yuibj	474	18	Codon	Codon	NNP
cord-321868-xk4yuibj	474	19	usage	usage	NN
cord-321868-xk4yuibj	474	20	tabulated	tabulate	VBN
cord-321868-xk4yuibj	474	21	from	from	IN
cord-321868-xk4yuibj	474	22	the	the	DT
cord-321868-xk4yuibj	474	23	GenBank	GenBank	NNP
cord-321868-xk4yuibj	474	24	genetic	genetic	JJ
cord-321868-xk4yuibj	474	25	sequence	sequence	NN
cord-321868-xk4yuibj	474	26	data	data	NN
cord-321868-xk4yuibj	474	27	Different	different	JJ
cord-321868-xk4yuibj	474	28	pattern	pattern	NN
cord-321868-xk4yuibj	474	29	of	of	IN
cord-321868-xk4yuibj	474	30	codon	codon	NN
cord-321868-xk4yuibj	474	31	recognition	recognition	NN
cord-321868-xk4yuibj	474	32	by	by	IN
cord-321868-xk4yuibj	474	33	mammalian	mammalian	JJ
cord-321868-xk4yuibj	474	34	mitochondrial	mitochondrial	NN
cord-321868-xk4yuibj	474	35	tANAs	tanas	ADD
cord-321868-xk4yuibj	474	36	Ty	ty	NN
cord-321868-xk4yuibj	474	37	elements	element	NNS
cord-321868-xk4yuibj	474	38	transpose	transpose	VBP
cord-321868-xk4yuibj	474	39	through	through	IN
cord-321868-xk4yuibj	474	40	an	an	DT
cord-321868-xk4yuibj	474	41	RNA	RNA	NNP
cord-321868-xk4yuibj	474	42	intermediate	intermediate	NN
cord-321868-xk4yuibj	474	43	The	the	DT
cord-321868-xk4yuibj	474	44	AGG	agg	NN
cord-321868-xk4yuibj	474	45	codon	codon	NN
cord-321868-xk4yuibj	474	46	is	be	VBZ
cord-321868-xk4yuibj	474	47	translated	translate	VBN
cord-321868-xk4yuibj	474	48	slowly	slowly	RB
cord-321868-xk4yuibj	474	49	in	in	RB
cord-321868-xk4yuibj	475	1	f.	f.	NNP
cord-321868-xk4yuibj	475	2	co/	co/	NNP
cord-321868-xk4yuibj	476	1	i	i	PRP
cord-321868-xk4yuibj	476	2	even	even	RB
cord-321868-xk4yuibj	476	3	at	at	IN
cord-321868-xk4yuibj	476	4	very	very	RB
cord-321868-xk4yuibj	476	5	low	low	JJ
cord-321868-xk4yuibj	476	6	expression	expression	NN
cord-321868-xk4yuibj	476	7	levels	level	NNS
cord-321868-xk4yuibj	476	8	Codon	Codon	NNP
cord-321868-xk4yuibj	476	9	recognition	recognition	NN
cord-321868-xk4yuibj	476	10	rules	rule	NNS
cord-321868-xk4yuibj	476	11	in	in	IN
cord-321868-xk4yuibj	476	12	yeast	yeast	NN
cord-321868-xk4yuibj	476	13	mitochondria	mitochondrion	NNS
cord-321868-xk4yuibj	476	14	Context	context	JJ
cord-321868-xk4yuibj	476	15	effects	effect	NNS
cord-321868-xk4yuibj	476	16	:	:	:
cord-321868-xk4yuibj	476	17	translation	translation	NN
cord-321868-xk4yuibj	476	18	of	of	IN
cord-321868-xk4yuibj	476	19	UAG	UAG	NNP
cord-321868-xk4yuibj	476	20	codon	codon	NN
cord-321868-xk4yuibj	476	21	by	by	IN
cord-321868-xk4yuibj	476	22	suppressor	suppressor	NN
cord-321868-xk4yuibj	476	23	tRNA	tRNA	NNP
cord-321868-xk4yuibj	476	24	is	be	VBZ
cord-321868-xk4yuibj	476	25	affected	affect	VBN
cord-321868-xk4yuibj	476	26	by	by	IN
cord-321868-xk4yuibj	476	27	the	the	DT
cord-321868-xk4yuibj	476	28	sequence	sequence	NN
cord-321868-xk4yuibj	476	29	following	follow	VBG
cord-321868-xk4yuibj	476	30	UAG	UAG	NNP
cord-321868-xk4yuibj	476	31	in	in	IN
cord-321868-xk4yuibj	476	32	the	the	DT
cord-321868-xk4yuibj	476	33	message	message	NN
cord-321868-xk4yuibj	476	34	The	the	DT
cord-321868-xk4yuibj	476	35	influence	influence	NN
cord-321868-xk4yuibj	476	36	of	of	IN
cord-321868-xk4yuibj	476	37	codon	codon	NN
cord-321868-xk4yuibj	476	38	context	context	NN
cord-321868-xk4yuibj	476	39	on	on	IN
cord-321868-xk4yuibj	476	40	genetic	genetic	JJ
cord-321868-xk4yuibj	476	41	code	code	NN
cord-321868-xk4yuibj	476	42	translation	translation	NN
cord-321868-xk4yuibj	477	1	An	an	DT
cord-321868-xk4yuibj	477	2	efficient	efficient	JJ
cord-321868-xk4yuibj	477	3	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	477	4	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	477	5	signal	signal	NN
cord-321868-xk4yuibj	477	6	in	in	IN
cord-321868-xk4yuibj	477	7	the	the	DT
cord-321868-xk4yuibj	477	8	polymerase	polymerase	NN
cord-321868-xk4yuibj	477	9	-	-	HYPH
cord-321868-xk4yuibj	477	10	encoding	encode	VBG
cord-321868-xk4yuibj	477	11	region	region	NN
cord-321868-xk4yuibj	477	12	of	of	IN
cord-321868-xk4yuibj	477	13	the	the	DT
cord-321868-xk4yuibj	477	14	coronavirus	coronavirus	NN
cord-321868-xk4yuibj	477	15	IBV	IBV	NNP
cord-321868-xk4yuibj	477	16	Characterization	characterization	NN
cord-321868-xk4yuibj	477	17	of	of	IN
cord-321868-xk4yuibj	477	18	an	an	DT
cord-321868-xk4yuibj	477	19	efficient	efficient	JJ
cord-321868-xk4yuibj	477	20	coronavirus	coronavirus	NN
cord-321868-xk4yuibj	477	21	ribosomal	ribosomal	NN
cord-321868-xk4yuibj	477	22	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	477	23	signal	signal	NN
cord-321868-xk4yuibj	477	24	:	:	:
cord-321868-xk4yuibj	477	25	requirement	requirement	NN
cord-321868-xk4yuibj	477	26	for	for	IN
cord-321868-xk4yuibj	477	27	an	an	DT
cord-321868-xk4yuibj	477	28	RNA	RNA	NNP
cord-321868-xk4yuibj	477	29	pseudoknot	pseudoknot	NN
cord-321868-xk4yuibj	477	30	Molecular	molecular	JJ
cord-321868-xk4yuibj	477	31	genetics	genetic	NNS
cord-321868-xk4yuibj	477	32	of	of	IN
cord-321868-xk4yuibj	477	33	yeast	yeast	NN
cord-321868-xk4yuibj	477	34	chromosomes	chromosome	VBZ
cord-321868-xk4yuibj	477	35	Evidence	evidence	NN
cord-321868-xk4yuibj	477	36	for	for	IN
cord-321868-xk4yuibj	477	37	transposition	transposition	NN
cord-321868-xk4yuibj	477	38	of	of	IN
cord-321868-xk4yuibj	477	39	dispersed	disperse	VBN
cord-321868-xk4yuibj	477	40	repetitive	repetitive	JJ
cord-321868-xk4yuibj	477	41	DNA	dna	NN
cord-321868-xk4yuibj	477	42	families	family	NNS
cord-321868-xk4yuibj	477	43	in	in	IN
cord-321868-xk4yuibj	477	44	yeast	yeast	NN
cord-321868-xk4yuibj	478	1	An	an	DT
cord-321868-xk4yuibj	478	2	effect	effect	NN
cord-321868-xk4yuibj	478	3	of	of	IN
cord-321868-xk4yuibj	478	4	codon	codon	NN
cord-321868-xk4yuibj	478	5	context	context	NN
cord-321868-xk4yuibj	478	6	on	on	IN
cord-321868-xk4yuibj	478	7	the	the	DT
cord-321868-xk4yuibj	478	8	mistranslation	mistranslation	NN
cord-321868-xk4yuibj	478	9	of	of	IN
cord-321868-xk4yuibj	478	10	UGU	UGU	NNP
cord-321868-xk4yuibj	478	11	codons	codon	NNS
cord-321868-xk4yuibj	478	12	in	in	IN
cord-321868-xk4yuibj	478	13	vitro	vitro	FW
cord-321868-xk4yuibj	478	14	6Galactosidase	6Galactosidase	NNP
cord-321868-xk4yuibj	478	15	gene	gene	NN
cord-321868-xk4yuibj	478	16	fusions	fusion	NNS
cord-321868-xk4yuibj	478	17	for	for	IN
cord-321868-xk4yuibj	478	18	analyzing	analyze	VBG
cord-321868-xk4yuibj	478	19	gene	gene	NN
cord-321868-xk4yuibj	478	20	expression	expression	NN
cord-321868-xk4yuibj	478	21	in	in	IN
cord-321868-xk4yuibj	478	22	Escherichia	Escherichia	NNP
cord-321868-xk4yuibj	478	23	co	co	NN
cord-321868-xk4yuibj	478	24	/	/	SYM
cord-321868-xk4yuibj	478	25	i	i	NN
cord-321868-xk4yuibj	478	26	and	and	CC
cord-321868-xk4yuibj	478	27	yeast	yeast	NN
cord-321868-xk4yuibj	478	28	tRNAy	trnay	CD
cord-321868-xk4yuibj	478	29	'	'	POS
cord-321868-xk4yuibj	478	30	functions	function	NNS
cord-321868-xk4yuibj	478	31	in	in	IN
cord-321868-xk4yuibj	478	32	directing	direct	VBG
cord-321868-xk4yuibj	478	33	the	the	DT
cord-321868-xk4yuibj	478	34	scanning	scanning	NN
cord-321868-xk4yuibj	478	35	ribosome	ribosome	NN
cord-321868-xk4yuibj	478	36	to	to	IN
cord-321868-xk4yuibj	478	37	the	the	DT
cord-321868-xk4yuibj	478	38	start	start	NN
cord-321868-xk4yuibj	478	39	site	site	NN
cord-321868-xk4yuibj	478	40	of	of	IN
cord-321868-xk4yuibj	478	41	translation	translation	NN
cord-321868-xk4yuibj	478	42	Nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	478	43	sequence	sequence	NN
cord-321868-xk4yuibj	478	44	of	of	IN
cord-321868-xk4yuibj	478	45	a	a	DT
cord-321868-xk4yuibj	478	46	yeast	yeast	NN
cord-321868-xk4yuibj	478	47	Ty	ty	NN
cord-321868-xk4yuibj	478	48	element	element	NN
cord-321868-xk4yuibj	478	49	:	:	:
cord-321868-xk4yuibj	478	50	evidence	evidence	NN
cord-321868-xk4yuibj	478	51	for	for	IN
cord-321868-xk4yuibj	478	52	an	an	DT
cord-321868-xk4yuibj	478	53	unusual	unusual	JJ
cord-321868-xk4yuibj	478	54	mechanism	mechanism	NN
cord-321868-xk4yuibj	478	55	of	of	IN
cord-321868-xk4yuibj	478	56	gene	gene	NN
cord-321868-xk4yuibj	478	57	expression	expression	NN
cord-321868-xk4yuibj	478	58	Efficient	efficient	JJ
cord-321868-xk4yuibj	478	59	translational	translational	JJ
cord-321868-xk4yuibj	478	60	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	478	61	occurs	occur	VBZ
cord-321868-xk4yuibj	478	62	within	within	IN
cord-321868-xk4yuibj	478	63	a	a	DT
cord-321868-xk4yuibj	478	64	conserved	conserved	JJ
cord-321868-xk4yuibj	478	65	sequence	sequence	NN
cord-321868-xk4yuibj	478	66	of	of	IN
cord-321868-xk4yuibj	478	67	the	the	DT
cord-321868-xk4yuibj	478	68	overlap	overlap	NN
cord-321868-xk4yuibj	478	69	between	between	IN
cord-321868-xk4yuibj	478	70	the	the	DT
cord-321868-xk4yuibj	478	71	two	two	CD
cord-321868-xk4yuibj	478	72	genes	gene	NNS
cord-321868-xk4yuibj	478	73	of	of	IN
cord-321868-xk4yuibj	478	74	a	a	DT
cord-321868-xk4yuibj	478	75	yeast	yeast	NN
cord-321868-xk4yuibj	478	76	Tyl	Tyl	NNP
cord-321868-xk4yuibj	478	77	transposon	transposon	NN
cord-321868-xk4yuibj	478	78	Structure	Structure	NNP
cord-321868-xk4yuibj	478	79	of	of	IN
cord-321868-xk4yuibj	478	80	yeast	yeast	NN
cord-321868-xk4yuibj	478	81	phenylalanine	phenylalanine	NN
cord-321868-xk4yuibj	478	82	-	-	HYPH
cord-321868-xk4yuibj	478	83	tRNA	trna	NN
cord-321868-xk4yuibj	478	84	genes	gene	NNS
cord-321868-xk4yuibj	478	85	:	:	:
cord-321868-xk4yuibj	478	86	an	an	DT
cord-321868-xk4yuibj	478	87	intervening	intervene	VBG
cord-321868-xk4yuibj	478	88	DNA	dna	NN
cord-321868-xk4yuibj	478	89	segment	segment	NN
cord-321868-xk4yuibj	478	90	within	within	IN
cord-321868-xk4yuibj	478	91	the	the	DT
cord-321868-xk4yuibj	478	92	region	region	NN
cord-321868-xk4yuibj	478	93	coding	code	VBG
cord-321868-xk4yuibj	478	94	for	for	IN
cord-321868-xk4yuibj	478	95	the	the	DT
cord-321868-xk4yuibj	478	96	tRNA	tRNA	NNP
cord-321868-xk4yuibj	478	97	Retroviruses	Retroviruses	NNPS
cord-321868-xk4yuibj	478	98	.	.	.
cord-321868-xk4yuibj	479	1	In	in	IN
cord-321868-xk4yuibj	479	2	Mobile	Mobile	NNP
cord-321868-xk4yuibj	479	3	Genetic	Genetic	NNP
cord-321868-xk4yuibj	479	4	Elements	Elements	NNP
cord-321868-xk4yuibj	479	5	Molecular	Molecular	NNP
cord-321868-xk4yuibj	479	6	model	model	NN
cord-321868-xk4yuibj	479	7	of	of	IN
cord-321868-xk4yuibj	479	8	ribosome	ribosome	NN
cord-321868-xk4yuibj	479	9	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	479	10	Frameshift	Frameshift	NNP
cord-321868-xk4yuibj	479	11	suppression	suppression	NN
cord-321868-xk4yuibj	479	12	in	in	IN
cord-321868-xk4yuibj	479	13	aminoacyl	aminoacyl	NNP
cord-321868-xk4yuibj	479	14	-	-	HYPH
cord-321868-xk4yuibj	479	15	tRNA	trna	NN
cord-321868-xk4yuibj	479	16	limited	limited	JJ
cord-321868-xk4yuibj	479	17	cells	cell	NNS
cord-321868-xk4yuibj	479	18	Slippery	slippery	JJ
cord-321868-xk4yuibj	479	19	runs	run	NNS
cord-321868-xk4yuibj	479	20	,	,	,
cord-321868-xk4yuibj	479	21	shifty	shifty	JJ
cord-321868-xk4yuibj	479	22	stops	stop	NNS
cord-321868-xk4yuibj	479	23	,	,	,
cord-321868-xk4yuibj	479	24	backward	backward	JJ
cord-321868-xk4yuibj	479	25	steps	step	NNS
cord-321868-xk4yuibj	479	26	,	,	,
cord-321868-xk4yuibj	479	27	and	and	CC
cord-321868-xk4yuibj	479	28	forward	forward	JJ
cord-321868-xk4yuibj	479	29	hops	hop	NNS
cord-321868-xk4yuibj	479	30	:	:	.
cord-321868-xk4yuibj	479	31	-2	-2	ADD
cord-321868-xk4yuibj	480	1	,	,	,
cord-321868-xk4yuibj	480	2	-1	-1	CD
cord-321868-xk4yuibj	480	3	,	,	,
cord-321868-xk4yuibj	481	1	+	+	CC
cord-321868-xk4yuibj	482	1	l	l	NNP
cord-321868-xk4yuibj	482	2	,	,	,
cord-321868-xk4yuibj	482	3	+2	+2	NNP
cord-321868-xk4yuibj	482	4	,	,	,
cord-321868-xk4yuibj	482	5	+5	+5	NNP
cord-321868-xk4yuibj	482	6	,	,	,
cord-321868-xk4yuibj	482	7	and	and	CC
cord-321868-xk4yuibj	482	8	+6	+6	CD
cord-321868-xk4yuibj	482	9	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	482	10	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	482	11	.	.	.
cord-321868-xk4yuibj	483	1	Cold	cold	JJ
cord-321868-xk4yuibj	483	2	Spring	Spring	NNP
cord-321868-xk4yuibj	483	3	Harbor	Harbor	NNP
cord-321868-xk4yuibj	483	4	Symp	Symp	NNP
cord-321868-xk4yuibj	483	5	Reading	reading	NN
cord-321868-xk4yuibj	483	6	-	-	HYPH
cord-321868-xk4yuibj	483	7	frame	frame	NN
cord-321868-xk4yuibj	483	8	switch	switch	NN
cord-321868-xk4yuibj	483	9	caused	cause	VBN
cord-321868-xk4yuibj	483	10	by	by	IN
cord-321868-xk4yuibj	483	11	basepair	basepair	NNP
cord-321868-xk4yuibj	483	12	formation	formation	NN
cord-321868-xk4yuibj	483	13	between	between	IN
cord-321868-xk4yuibj	483	14	the	the	DT
cord-321868-xk4yuibj	483	15	3'end	3'end	CD
cord-321868-xk4yuibj	483	16	of	of	IN
cord-321868-xk4yuibj	483	17	16s	16s	NNPS
cord-321868-xk4yuibj	483	18	rRNA	rRNA	NNP
cord-321868-xk4yuibj	483	19	and	and	CC
cord-321868-xk4yuibj	484	1	the	the	DT
cord-321868-xk4yuibj	484	2	mRNA	mRNA	NNP
cord-321868-xk4yuibj	484	3	during	during	IN
cord-321868-xk4yuibj	484	4	elongation	elongation	NN
cord-321868-xk4yuibj	484	5	of	of	IN
cord-321868-xk4yuibj	484	6	protein	protein	NN
cord-321868-xk4yuibj	484	7	synthesis	synthesis	NN
cord-321868-xk4yuibj	484	8	in	in	IN
cord-321868-xk4yuibj	484	9	Escherichia	Escherichia	NNP
cord-321868-xk4yuibj	485	1	co	co	NNP
cord-321868-xk4yuibj	485	2	/	/	SYM
cord-321868-xk4yuibj	485	3	i	i	PRP
cord-321868-xk4yuibj	485	4	f.	f.	VBP
cord-321868-xk4yuibj	485	5	co/	co/	NNP
cord-321868-xk4yuibj	486	1	i	i	PRP
cord-321868-xk4yuibj	486	2	ribosomes	ribosomes	VBP
cord-321868-xk4yuibj	486	3	re	re	NN
cord-321868-xk4yuibj	486	4	-	-	NN
cord-321868-xk4yuibj	486	5	phase	phase	NN
cord-321868-xk4yuibj	487	1	on	on	IN
cord-321868-xk4yuibj	487	2	retroviral	retroviral	JJ
cord-321868-xk4yuibj	487	3	frameshift	frameshift	NN
cord-321868-xk4yuibj	487	4	signals	signal	NNS
cord-321868-xk4yuibj	487	5	at	at	IN
cord-321868-xk4yuibj	487	6	rates	rate	NNS
cord-321868-xk4yuibj	487	7	ranging	range	VBG
cord-321868-xk4yuibj	487	8	from	from	IN
cord-321868-xk4yuibj	487	9	2	2	CD
cord-321868-xk4yuibj	487	10	to	to	TO
cord-321868-xk4yuibj	487	11	50	50	CD
cord-321868-xk4yuibj	487	12	percent	percent	NN
cord-321868-xk4yuibj	487	13	On	on	IN
cord-321868-xk4yuibj	487	14	the	the	DT
cord-321868-xk4yuibj	487	15	mechanism	mechanism	NN
cord-321868-xk4yuibj	487	16	of	of	IN
cord-321868-xk4yuibj	487	17	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	487	18	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	487	19	at	at	IN
cord-321868-xk4yuibj	487	20	hungry	hungry	JJ
cord-321868-xk4yuibj	487	21	codons	codon	NNS
cord-321868-xk4yuibj	487	22	Yeast	Yeast	NNP
cord-321868-xk4yuibj	487	23	tRNALBU	tRNALBU	NNP
cord-321868-xk4yuibj	487	24	(	(	-LRB-
cord-321868-xk4yuibj	487	25	anticodon	anticodon	NNP
cord-321868-xk4yuibj	487	26	UAG	UAG	NNP
cord-321868-xk4yuibj	487	27	)	)	-RRB-
cord-321868-xk4yuibj	487	28	translates	translate	VBZ
cord-321868-xk4yuibj	487	29	all	all	DT
cord-321868-xk4yuibj	487	30	six	six	CD
cord-321868-xk4yuibj	487	31	leucine	leucine	NN
cord-321868-xk4yuibj	487	32	codons	codon	NNS
cord-321868-xk4yuibj	487	33	in	in	IN
cord-321868-xk4yuibj	487	34	extracts	extract	NNS
cord-321868-xk4yuibj	487	35	from	from	IN
cord-321868-xk4yuibj	487	36	interferon	interferon	NN
cord-321868-xk4yuibj	487	37	treated	treat	VBD
cord-321868-xk4yuibj	487	38	ceils	ceils	NNP
cord-321868-xk4yuibj	487	39	Expression	Expression	NNP
cord-321868-xk4yuibj	487	40	strategies	strategy	NNS
cord-321868-xk4yuibj	487	41	of	of	IN
cord-321868-xk4yuibj	487	42	the	the	DT
cord-321868-xk4yuibj	487	43	yeast	yeast	NN
cord-321868-xk4yuibj	487	44	retrotransposon	retrotransposon	NN
cord-321868-xk4yuibj	487	45	Ty	Ty	NNP
cord-321868-xk4yuibj	487	46	:	:	:
cord-321868-xk4yuibj	487	47	a	a	DT
cord-321868-xk4yuibj	487	48	short	short	JJ
cord-321868-xk4yuibj	487	49	sequence	sequence	NN
cord-321868-xk4yuibj	487	50	directs	direct	VBZ
cord-321868-xk4yuibj	487	51	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	487	52	frameshifting	frameshifte	VBG
cord-321868-xk4yuibj	487	53	HIV	HIV	NNP
cord-321868-xk4yuibj	487	54	expression	expression	NN
cord-321868-xk4yuibj	487	55	strategies	strategy	NNS
cord-321868-xk4yuibj	487	56	:	:	:
cord-321868-xk4yuibj	487	57	ribosomal	ribosomal	JJ
cord-321868-xk4yuibj	487	58	frameshifting	frameshifting	NN
cord-321868-xk4yuibj	487	59	is	be	VBZ
cord-321868-xk4yuibj	487	60	directed	direct	VBN
cord-321868-xk4yuibj	487	61	by	by	IN
cord-321868-xk4yuibj	487	62	a	a	DT
cord-321868-xk4yuibj	487	63	short	short	JJ
cord-321868-xk4yuibj	487	64	sequence	sequence	NN
cord-321868-xk4yuibj	487	65	in	in	IN
cord-321868-xk4yuibj	487	66	both	both	DT
cord-321868-xk4yuibj	487	67	mammalian	mammalian	JJ
cord-321868-xk4yuibj	487	68	and	and	CC
cord-321868-xk4yuibj	487	69	yeast	yeast	NN
cord-321868-xk4yuibj	487	70	systems	system	NNS
cord-321868-xk4yuibj	487	71	Craigen	Craigen	NNP
cord-321868-xk4yuibj	487	72	,	,	,
cord-321868-xk4yuibj	487	73	W.	W.	NNP
cord-321868-xk4yuibj	487	74	J	J	NNP
cord-321868-xk4yuibj	487	75	..	..	NFP
cord-321868-xk4yuibj	487	76	and	and	CC
cord-321868-xk4yuibj	487	77	Caskey	Caskey	NNP
cord-321868-xk4yuibj	487	78	,	,	,
cord-321868-xk4yuibj	487	79	C.	C.	NNP
cord-321868-xk4yuibj	487	80	T.	T.	NNP
cord-321868-xk4yuibj	487	81	(	(	-LRB-
cord-321868-xk4yuibj	487	82	1986	1986	CD
cord-321868-xk4yuibj	487	83	)	)	-RRB-
cord-321868-xk4yuibj	487	84	.	.	.
cord-321868-xk4yuibj	488	1	Expression	expression	NN
cord-321868-xk4yuibj	488	2	of	of	IN
cord-321868-xk4yuibj	488	3	peptide	peptide	NN
cord-321868-xk4yuibj	488	4	chain	chain	NN
cord-321868-xk4yuibj	488	5	release	release	NN
cord-321868-xk4yuibj	488	6	factor	factor	NN
cord-321868-xk4yuibj	488	7	2	2	CD
cord-321868-xk4yuibj	488	8	requires	require	VBZ
cord-321868-xk4yuibj	488	9	high	high	JJ
cord-321868-xk4yuibj	488	10	-	-	HYPH
cord-321868-xk4yuibj	488	11	efficiency	efficiency	NN
cord-321868-xk4yuibj	488	12	frameshift	frameshift	NN
cord-321868-xk4yuibj	488	13	.	.	.
cord-321868-xk4yuibj	489	1	Nature	nature	NN
cord-321868-xk4yuibj	489	2	322	322	CD
cord-321868-xk4yuibj	489	3	,	,	,
cord-321868-xk4yuibj	489	4	273	273	CD
cord-321868-xk4yuibj	489	5	-	-	HYPH
cord-321868-xk4yuibj	489	6	275.Craigen	275.craigen	CD
cord-321868-xk4yuibj	489	7	,	,	,
cord-321868-xk4yuibj	489	8	W.	W.	NNP
cord-321868-xk4yuibj	489	9	J.	J.	NNP
cord-321868-xk4yuibj	489	10	,	,	,
cord-321868-xk4yuibj	489	11	Cook	Cook	NNP
cord-321868-xk4yuibj	489	12	,	,	,
cord-321868-xk4yuibj	489	13	R.	R.	NNP
cord-321868-xk4yuibj	489	14	G	G	NNP
cord-321868-xk4yuibj	489	15	..	..	NFP
cord-321868-xk4yuibj	489	16	Tate	Tate	NNP
cord-321868-xk4yuibj	489	17	,	,	,
cord-321868-xk4yuibj	489	18	W.	W.	NNP
cord-321868-xk4yuibj	489	19	P.	P.	NNP
cord-321868-xk4yuibj	489	20	,	,	,
cord-321868-xk4yuibj	489	21	and	and	CC
cord-321868-xk4yuibj	489	22	Caskey	Caskey	NNP
cord-321868-xk4yuibj	489	23	,	,	,
cord-321868-xk4yuibj	489	24	C.	C.	NNP
cord-321868-xk4yuibj	489	25	T.	T.	NNP
cord-321868-xk4yuibj	489	26	(	(	-LRB-
cord-321868-xk4yuibj	489	27	1985	1985	CD
cord-321868-xk4yuibj	489	28	)	)	-RRB-
cord-321868-xk4yuibj	489	29	.	.	.
cord-321868-xk4yuibj	490	1	Bacterial	bacterial	JJ
cord-321868-xk4yuibj	490	2	peptide	peptide	NN
cord-321868-xk4yuibj	490	3	chain	chain	NN
cord-321868-xk4yuibj	490	4	release	release	NN
cord-321868-xk4yuibj	490	5	factors	factor	NNS
cord-321868-xk4yuibj	490	6	:	:	:
cord-321868-xk4yuibj	490	7	conserved	conserved	JJ
cord-321868-xk4yuibj	490	8	primary	primary	JJ
cord-321868-xk4yuibj	490	9	structure	structure	NN
cord-321868-xk4yuibj	490	10	and	and	CC
cord-321868-xk4yuibj	490	11	possible	possible	JJ
cord-321868-xk4yuibj	490	12	frameshift	frameshift	NN
cord-321868-xk4yuibj	490	13	regulation	regulation	NN
cord-321868-xk4yuibj	490	14	of	of	IN
cord-321868-xk4yuibj	490	15	release	release	NN
cord-321868-xk4yuibj	490	16	factor	factor	NN
cord-321868-xk4yuibj	490	17	2	2	CD
cord-321868-xk4yuibj	490	18	.	.	.
cord-321868-xk4yuibj	491	1	Proc	proc	VB
cord-321868-xk4yuibj	491	2	.	.	.
cord-321868-xk4yuibj	492	1	Natl	Natl	NNP
cord-321868-xk4yuibj	492	2	.	.	.
cord-321868-xk4yuibj	493	1	Acad	Acad	NNP
cord-321868-xk4yuibj	493	2	.	.	.
cord-321868-xk4yuibj	494	1	Sci	Sci	NNP
cord-321868-xk4yuibj	494	2	USA	USA	NNP
cord-321868-xk4yuibj	494	3	82	82	CD
cord-321868-xk4yuibj	494	4	,	,	,
cord-321868-xk4yuibj	494	5	3616	3616	CD
cord-321868-xk4yuibj	494	6	-	-	HYPH
cord-321868-xk4yuibj	494	7	3620.Derbyshire	3620.derbyshire	CD
cord-321868-xk4yuibj	494	8	,	,	,
cord-321868-xk4yuibj	494	9	K.	K.	NNP
cord-321868-xk4yuibj	494	10	M.	M.	NNP
cord-321868-xk4yuibj	494	11	,	,	,
cord-321868-xk4yuibj	494	12	Salvo	Salvo	NNP
cord-321868-xk4yuibj	494	13	,	,	,
cord-321868-xk4yuibj	494	14	J.	J.	NNP
cord-321868-xk4yuibj	494	15	J.	J.	NNP
cord-321868-xk4yuibj	494	16	,	,	,
cord-321868-xk4yuibj	494	17	and	and	CC
cord-321868-xk4yuibj	494	18	Grindley	Grindley	NNP
cord-321868-xk4yuibj	494	19	,	,	,
cord-321868-xk4yuibj	495	1	N.	N.	NNP
cord-321868-xk4yuibj	495	2	D.	D.	NNP
cord-321868-xk4yuibj	495	3	F.	F.	NNP
cord-321868-xk4yuibj	495	4	(	(	-LRB-
cord-321868-xk4yuibj	495	5	1986	1986	CD
cord-321868-xk4yuibj	495	6	)	)	-RRB-
cord-321868-xk4yuibj	495	7	.	.	.
cord-321868-xk4yuibj	496	1	A	a	DT
cord-321868-xk4yuibj	496	2	simple	simple	JJ
cord-321868-xk4yuibj	496	3	and	and	CC
cord-321868-xk4yuibj	496	4	efficient	efficient	JJ
cord-321868-xk4yuibj	496	5	procedure	procedure	NN
cord-321868-xk4yuibj	496	6	for	for	IN
cord-321868-xk4yuibj	496	7	saturation	saturation	NN
cord-321868-xk4yuibj	496	8	mutagenesis	mutagenesis	NN
cord-321868-xk4yuibj	496	9	using	use	VBG
cord-321868-xk4yuibj	496	10	mixed	mixed	JJ
cord-321868-xk4yuibj	496	11	oligodeoxynucleotides	oligodeoxynucleotide	NNS
cord-321868-xk4yuibj	496	12	.	.	.
cord-321868-xk4yuibj	497	1	Gene	gene	NN
cord-321868-xk4yuibj	497	2	46	46	CD
cord-321868-xk4yuibj	497	3	,	,	,
cord-321868-xk4yuibj	497	4	145	145	CD
cord-321868-xk4yuibj	497	5	-	-	SYM
cord-321868-xk4yuibj	497	6	152.Donahue	152.donahue	CD
cord-321868-xk4yuibj	497	7	,	,	,
cord-321868-xk4yuibj	497	8	T.	T.	NNP
cord-321868-xk4yuibj	497	9	F.	F.	NNP
cord-321868-xk4yuibj	497	10	,	,	,
cord-321868-xk4yuibj	497	11	Farabaugh	Farabaugh	NNP
cord-321868-xk4yuibj	497	12	,	,	,
cord-321868-xk4yuibj	497	13	f	f	NNP
cord-321868-xk4yuibj	497	14	?	?	.
cord-321868-xk4yuibj	497	15	J.	J.	NNP
cord-321868-xk4yuibj	497	16	,	,	,
cord-321868-xk4yuibj	497	17	and	and	CC
cord-321868-xk4yuibj	497	18	Fink	Fink	NNP
cord-321868-xk4yuibj	497	19	,	,	,
cord-321868-xk4yuibj	497	20	G.	G.	NNP
cord-321868-xk4yuibj	497	21	R.	R.	NNP
cord-321868-xk4yuibj	497	22	(	(	-LRB-
cord-321868-xk4yuibj	497	23	1982	1982	CD
cord-321868-xk4yuibj	497	24	)	)	-RRB-
cord-321868-xk4yuibj	497	25	.	.	.
cord-321868-xk4yuibj	498	1	Fox	Fox	NNP
cord-321868-xk4yuibj	498	2	,	,	,
cord-321868-xk4yuibj	498	3	T.	T.	NNP
cord-321868-xk4yuibj	498	4	D.	D.	NNP
cord-321868-xk4yuibj	498	5	,	,	,
cord-321868-xk4yuibj	498	6	and	and	CC
cord-321868-xk4yuibj	498	7	Weiss	Weiss	NNP
cord-321868-xk4yuibj	498	8	-	-	HYPH
cord-321868-xk4yuibj	498	9	Brummer	Brummer	NNP
cord-321868-xk4yuibj	498	10	,	,	,
cord-321868-xk4yuibj	498	11	8	8	CD
cord-321868-xk4yuibj	498	12	.	.	.
cord-321868-xk4yuibj	499	1	(	(	-LRB-
cord-321868-xk4yuibj	499	2	1980	1980	CD
cord-321868-xk4yuibj	499	3	)	)	-RRB-
cord-321868-xk4yuibj	499	4	.	.	.
cord-321868-xk4yuibj	500	1	Leaky	leaky	JJ
cord-321868-xk4yuibj	500	2	+	+	CC
cord-321868-xk4yuibj	500	3	l	l	NN
cord-321868-xk4yuibj	500	4	and	and	CC
cord-321868-xk4yuibj	500	5	-1	-1	NNP
cord-321868-xk4yuibj	500	6	frame	frame	JJ
cord-321868-xk4yuibj	500	7	shift	shift	NN
cord-321868-xk4yuibj	500	8	mutations	mutation	NNS
cord-321868-xk4yuibj	500	9	at	at	IN
cord-321868-xk4yuibj	500	10	the	the	DT
cord-321868-xk4yuibj	500	11	same	same	JJ
cord-321868-xk4yuibj	500	12	site	site	NN
cord-321868-xk4yuibj	500	13	in	in	IN
cord-321868-xk4yuibj	500	14	a	a	DT
cord-321868-xk4yuibj	500	15	yeast	yeast	NN
cord-321868-xk4yuibj	500	16	mitochondrial	mitochondrial	NN
cord-321868-xk4yuibj	500	17	gene	gene	NN
cord-321868-xk4yuibj	500	18	.	.	.
cord-321868-xk4yuibj	501	1	Nature	nature	NN
cord-321868-xk4yuibj	501	2	288	288	CD
cord-321868-xk4yuibj	501	3	,	,	,
cord-321868-xk4yuibj	501	4	60	60	CD
cord-321868-xk4yuibj	501	5	-	-	SYM
cord-321868-xk4yuibj	501	6	63.Gafner	63.gafner	CD
cord-321868-xk4yuibj	501	7	,	,	,
cord-321868-xk4yuibj	501	8	J.	J.	NNP
cord-321868-xk4yuibj	501	9	,	,	,
cord-321868-xk4yuibj	501	10	De	De	NNP
cord-321868-xk4yuibj	501	11	Robertis	Robertis	NNP
cord-321868-xk4yuibj	501	12	,	,	,
cord-321868-xk4yuibj	501	13	E.	E.	NNP
cord-321868-xk4yuibj	501	14	M.	M.	NNP
cord-321868-xk4yuibj	501	15	,	,	,
cord-321868-xk4yuibj	501	16	and	and	CC
cord-321868-xk4yuibj	501	17	Philippsen	Philippsen	NNP
cord-321868-xk4yuibj	501	18	,	,	,
cord-321868-xk4yuibj	501	19	f	f	NNP
cord-321868-xk4yuibj	501	20	?	?	.
cord-321868-xk4yuibj	502	1	(	(	-LRB-
cord-321868-xk4yuibj	502	2	1963	1963	CD
cord-321868-xk4yuibj	502	3	)	)	-RRB-
cord-321868-xk4yuibj	502	4	.	.	.
cord-321868-xk4yuibj	503	1	Delta	Delta	NNP
cord-321868-xk4yuibj	503	2	sequences	sequence	NNS
cord-321868-xk4yuibj	503	3	in	in	IN
cord-321868-xk4yuibj	503	4	the	the	DT
cord-321868-xk4yuibj	503	5	5	5	CD
cord-321868-xk4yuibj	503	6	'	'	``
cord-321868-xk4yuibj	503	7	non	non	JJ
cord-321868-xk4yuibj	503	8	-	-	JJ
cord-321868-xk4yuibj	503	9	coding	coding	JJ
cord-321868-xk4yuibj	503	10	region	region	NN
cord-321868-xk4yuibj	503	11	of	of	IN
cord-321868-xk4yuibj	503	12	yeast	yeast	NN
cord-321868-xk4yuibj	503	13	tRNA	tRNA	NNP
cord-321868-xk4yuibj	503	14	genes	gene	NNS
cord-321868-xk4yuibj	503	15	,	,	,
cord-321868-xk4yuibj	503	16	EMBO	EMBO	NNP
cord-321868-xk4yuibj	503	17	J.	J.	NNP
cord-321868-xk4yuibj	503	18	2	2	CD
cord-321868-xk4yuibj	503	19	,	,	,
cord-321868-xk4yuibj	503	20	583	583	CD
cord-321868-xk4yuibj	503	21	-	-	SYM
cord-321868-xk4yuibj	503	22	591.Garfinkel	591.garfinkel	CD
cord-321868-xk4yuibj	503	23	,	,	,
cord-321868-xk4yuibj	503	24	D.	D.	NNP
cord-321868-xk4yuibj	503	25	J.	J.	NNP
cord-321868-xk4yuibj	503	26	,	,	,
cord-321868-xk4yuibj	503	27	Boeke	Boeke	NNP
cord-321868-xk4yuibj	503	28	,	,	,
cord-321868-xk4yuibj	503	29	J.	J.	NNP
cord-321868-xk4yuibj	503	30	D.	D.	NNP
cord-321868-xk4yuibj	503	31	,	,	,
cord-321868-xk4yuibj	503	32	and	and	CC
cord-321868-xk4yuibj	504	1	Fink	Fink	NNP
cord-321868-xk4yuibj	504	2	,	,	,
cord-321868-xk4yuibj	504	3	G.	G.	NNP
cord-321868-xk4yuibj	504	4	R.	R.	NNP
cord-321868-xk4yuibj	504	5	(	(	-LRB-
cord-321868-xk4yuibj	504	6	1965	1965	CD
cord-321868-xk4yuibj	504	7	)	)	-RRB-
cord-321868-xk4yuibj	504	8	.	.	.
cord-321868-xk4yuibj	505	1	Ty	ty	NN
cord-321868-xk4yuibj	505	2	element	element	NN
cord-321868-xk4yuibj	505	3	transposition	transposition	NN
cord-321868-xk4yuibj	505	4	:	:	:
cord-321868-xk4yuibj	505	5	reverse	reverse	JJ
cord-321868-xk4yuibj	505	6	transcriptase	transcriptase	NN
cord-321868-xk4yuibj	505	7	and	and	CC
cord-321868-xk4yuibj	505	8	virus	virus	NN
cord-321868-xk4yuibj	505	9	-	-	HYPH
cord-321868-xk4yuibj	505	10	like	like	JJ
cord-321868-xk4yuibj	505	11	particles	particle	NNS
cord-321868-xk4yuibj	505	12	,	,	,
cord-321868-xk4yuibj	505	13	Cell	cell	NN
cord-321868-xk4yuibj	505	14	42	42	CD
cord-321868-xk4yuibj	505	15	,	,	,
cord-321868-xk4yuibj	505	16	507	507	CD
cord-321868-xk4yuibj	505	17	-	-	SYM
cord-321868-xk4yuibj	505	18	517.Guarente	517.guarente	CD
cord-321868-xk4yuibj	505	19	,	,	,
cord-321868-xk4yuibj	505	20	L.	L.	NNP
cord-321868-xk4yuibj	505	21	,	,	,
cord-321868-xk4yuibj	505	22	Yocum	Yocum	NNP
cord-321868-xk4yuibj	505	23	,	,	,
cord-321868-xk4yuibj	505	24	R.	R.	NNP
cord-321868-xk4yuibj	505	25	,	,	,
cord-321868-xk4yuibj	505	26	and	and	CC
cord-321868-xk4yuibj	505	27	Gifford	Gifford	NNP
cord-321868-xk4yuibj	505	28	,	,	,
cord-321868-xk4yuibj	505	29	t	t	NNP
cord-321868-xk4yuibj	505	30	?	?	.
cord-321868-xk4yuibj	505	31	(	(	-LRB-
cord-321868-xk4yuibj	505	32	1982	1982	CD
cord-321868-xk4yuibj	505	33	)	)	-RRB-
cord-321868-xk4yuibj	505	34	.	.	.
cord-321868-xk4yuibj	506	1	A	a	DT
cord-321868-xk4yuibj	506	2	GALlO	GALlO	NNP
cord-321868-xk4yuibj	506	3	-	-	HYPH
cord-321868-xk4yuibj	506	4	CYCI	CYCI	NNP
cord-321868-xk4yuibj	506	5	hybrid	hybrid	NN
cord-321868-xk4yuibj	506	6	yeast	yeast	NN
cord-321868-xk4yuibj	506	7	promoter	promoter	NN
cord-321868-xk4yuibj	506	8	identifies	identify	VBZ
cord-321868-xk4yuibj	506	9	the	the	DT
cord-321868-xk4yuibj	506	10	GAL4	GAL4	NNP
cord-321868-xk4yuibj	506	11	regulatory	regulatory	JJ
cord-321868-xk4yuibj	506	12	region	region	NN
cord-321868-xk4yuibj	506	13	as	as	IN
cord-321868-xk4yuibj	506	14	an	an	DT
cord-321868-xk4yuibj	506	15	upstream	upstream	JJ
cord-321868-xk4yuibj	506	16	site	site	NN
cord-321868-xk4yuibj	506	17	.	.	.
cord-321868-xk4yuibj	507	1	Proc	proc	VB
cord-321868-xk4yuibj	507	2	.	.	.
cord-321868-xk4yuibj	508	1	Natl	Natl	NNP
cord-321868-xk4yuibj	508	2	.	.	.
cord-321868-xk4yuibj	509	1	Acad	Acad	NNP
cord-321868-xk4yuibj	509	2	.	.	.
cord-321868-xk4yuibj	510	1	Sci	Sci	NNP
cord-321868-xk4yuibj	510	2	.	.	NNP
cord-321868-xk4yuibj	510	3	USA	USA	NNP
cord-321868-xk4yuibj	510	4	79	79	CD
cord-321868-xk4yuibj	510	5	,	,	,
cord-321868-xk4yuibj	510	6	7410	7410	CD
cord-321868-xk4yuibj	510	7	-	-	HYPH
cord-321868-xk4yuibj	510	8	7414	7414	CD
cord-321868-xk4yuibj	510	9	.	.	.
cord-321868-xk4yuibj	511	1	F	F	NNP
cord-321868-xk4yuibj	511	2	,	,	,
cord-321868-xk4yuibj	511	3	and	and	CC
cord-321868-xk4yuibj	511	4	Hall	Hall	NNP
cord-321868-xk4yuibj	511	5	,	,	,
cord-321868-xk4yuibj	511	6	8	8	CD
cord-321868-xk4yuibj	511	7	.	.	.
cord-321868-xk4yuibj	511	8	D.	D.	NNP
cord-321868-xk4yuibj	511	9	(	(	-LRB-
cord-321868-xk4yuibj	511	10	1977	1977	CD
cord-321868-xk4yuibj	511	11	)	)	-RRB-
cord-321868-xk4yuibj	511	12	.	.	.
cord-321868-xk4yuibj	512	1	Molecular	molecular	JJ
cord-321868-xk4yuibj	512	2	characterization	characterization	NN
cord-321868-xk4yuibj	512	3	of	of	IN
cord-321868-xk4yuibj	512	4	the	the	DT
cord-321868-xk4yuibj	512	5	tyrosine	tyrosine	NN
cord-321868-xk4yuibj	512	6	tRNA	trna	NN
cord-321868-xk4yuibj	512	7	genes	gene	NNS
cord-321868-xk4yuibj	512	8	in	in	IN
cord-321868-xk4yuibj	512	9	yeast	yeast	NN
cord-321868-xk4yuibj	512	10	.	.	.
cord-321868-xk4yuibj	513	1	Nature	nature	NN
cord-321868-xk4yuibj	513	2	267	267	CD
cord-321868-xk4yuibj	513	3	,	,	,
cord-321868-xk4yuibj	513	4	639	639	CD
cord-321868-xk4yuibj	513	5	-	-	HYPH
cord-321868-xk4yuibj	513	6	641.Olson	641.olson	CD
cord-321868-xk4yuibj	513	7	,	,	,
cord-321868-xk4yuibj	513	8	M.	M.	NNP
cord-321868-xk4yuibj	513	9	V.	V.	NNP
cord-321868-xk4yuibj	513	10	,	,	,
cord-321868-xk4yuibj	513	11	Page	Page	NNP
cord-321868-xk4yuibj	513	12	,	,	,
cord-321868-xk4yuibj	513	13	G.	G.	NNP
cord-321868-xk4yuibj	513	14	S.	S.	NNP
cord-321868-xk4yuibj	513	15	,	,	,
cord-321868-xk4yuibj	513	16	Sentenac	Sentenac	NNP
cord-321868-xk4yuibj	513	17	,	,	,
cord-321868-xk4yuibj	513	18	A.	A.	NNP
cord-321868-xk4yuibj	513	19	,	,	,
cord-321868-xk4yuibj	513	20	Piper	Piper	NNP
cord-321868-xk4yuibj	513	21	,	,	,
cord-321868-xk4yuibj	513	22	F	F	NNP
cord-321868-xk4yuibj	513	23	!	!	.
cord-321868-xk4yuibj	514	1	W.	W.	NNP
cord-321868-xk4yuibj	514	2	,	,	,
cord-321868-xk4yuibj	514	3	Worthington	Worthington	NNP
cord-321868-xk4yuibj	514	4	,	,	,
cord-321868-xk4yuibj	514	5	M	M	NNP
cord-321868-xk4yuibj	514	6	..	..	NNP
cord-321868-xk4yuibj	514	7	Weiss	Weiss	NNP
cord-321868-xk4yuibj	514	8	,	,	,
cord-321868-xk4yuibj	514	9	R.	R.	NNP
cord-321868-xk4yuibj	514	10	B.	B.	NNP
cord-321868-xk4yuibj	514	11	,	,	,
cord-321868-xk4yuibj	514	12	and	and	CC
cord-321868-xk4yuibj	514	13	Hall	Hall	NNP
cord-321868-xk4yuibj	514	14	,	,	,
cord-321868-xk4yuibj	514	15	8	8	CD
cord-321868-xk4yuibj	514	16	.	.	.
cord-321868-xk4yuibj	514	17	D.	D.	NNP
cord-321868-xk4yuibj	514	18	(	(	-LRB-
cord-321868-xk4yuibj	514	19	1981	1981	CD
cord-321868-xk4yuibj	514	20	)	)	-RRB-
cord-321868-xk4yuibj	514	21	.	.	.
cord-321868-xk4yuibj	515	1	Only	only	RB
cord-321868-xk4yuibj	515	2	one	one	CD
cord-321868-xk4yuibj	515	3	of	of	IN
cord-321868-xk4yuibj	515	4	two	two	CD
cord-321868-xk4yuibj	515	5	closely	closely	RB
cord-321868-xk4yuibj	515	6	related	relate	VBN
cord-321868-xk4yuibj	515	7	yeast	yeast	NN
cord-321868-xk4yuibj	515	8	suppressor	suppressor	NN
cord-321868-xk4yuibj	515	9	tRNA	tRNA	NNP
cord-321868-xk4yuibj	515	10	genes	gene	NNS
cord-321868-xk4yuibj	515	11	contains	contain	VBZ
cord-321868-xk4yuibj	515	12	an	an	DT
cord-321868-xk4yuibj	515	13	intervening	intervene	VBG
cord-321868-xk4yuibj	515	14	sequence	sequence	NN
cord-321868-xk4yuibj	515	15	.	.	.
cord-321868-xk4yuibj	516	1	Nature	nature	NN
cord-321868-xk4yuibj	516	2	291	291	CD
cord-321868-xk4yuibj	516	3	,	,	,
cord-321868-xk4yuibj	516	4	464	464	CD
cord-321868-xk4yuibj	516	5	-	-	SYM
cord-321868-xk4yuibj	516	6	469	469	CD
cord-321868-xk4yuibj	516	7	.	.	.
cord-321868-xk4yuibj	517	1	RajBhandary	rajbhandary	RB
cord-321868-xk4yuibj	517	2	,	,	,
cord-321868-xk4yuibj	517	3	U.	U.	NNP
cord-321868-xk4yuibj	517	4	L.	L.	NNP
cord-321868-xk4yuibj	517	5	,	,	,
cord-321868-xk4yuibj	517	6	Chang	Chang	NNP
cord-321868-xk4yuibj	517	7	,	,	,
cord-321868-xk4yuibj	517	8	J.	J.	NNP
cord-321868-xk4yuibj	517	9	H.	H.	NNP
cord-321868-xk4yuibj	517	10	,	,	,
cord-321868-xk4yuibj	517	11	Stuart	Stuart	NNP
cord-321868-xk4yuibj	517	12	,	,	,
cord-321868-xk4yuibj	517	13	A.	A.	NNP
cord-321868-xk4yuibj	517	14	,	,	,
cord-321868-xk4yuibj	517	15	Faulkner	Faulkner	NNP
cord-321868-xk4yuibj	517	16	,	,	,
cord-321868-xk4yuibj	517	17	B.	B.	NNP
cord-321868-xk4yuibj	517	18	D.	D.	NNP
cord-321868-xk4yuibj	517	19	,	,	,
cord-321868-xk4yuibj	517	20	Hoskinson	Hoskinson	NNP
cord-321868-xk4yuibj	517	21	,	,	,
cord-321868-xk4yuibj	517	22	R.	R.	NNP
cord-321868-xk4yuibj	517	23	M.	M.	NNP
cord-321868-xk4yuibj	517	24	,	,	,
cord-321868-xk4yuibj	517	25	and	and	CC
cord-321868-xk4yuibj	517	26	Khorana	Khorana	NNP
cord-321868-xk4yuibj	517	27	,	,	,
cord-321868-xk4yuibj	517	28	H.	H.	NNP
cord-321868-xk4yuibj	517	29	G.	G.	NNP
cord-321868-xk4yuibj	517	30	(	(	-LRB-
cord-321868-xk4yuibj	517	31	1967	1967	CD
cord-321868-xk4yuibj	517	32	)	)	-RRB-
cord-321868-xk4yuibj	517	33	.	.	.
cord-321868-xk4yuibj	518	1	The	the	DT
cord-321868-xk4yuibj	518	2	primary	primary	JJ
cord-321868-xk4yuibj	518	3	structure	structure	NN
cord-321868-xk4yuibj	518	4	of	of	IN
cord-321868-xk4yuibj	518	5	yeast	yeast	NN
cord-321868-xk4yuibj	518	6	phenylalanine	phenylalanine	NN
cord-321868-xk4yuibj	518	7	transfer	transfer	NN
cord-321868-xk4yuibj	518	8	RNA	RNA	NNP
cord-321868-xk4yuibj	518	9	.	.	.
cord-321868-xk4yuibj	519	1	Proc	proc	VB
cord-321868-xk4yuibj	519	2	.	.	.
cord-321868-xk4yuibj	520	1	Natl	Natl	NNP
cord-321868-xk4yuibj	520	2	.	.	.
cord-321868-xk4yuibj	521	1	Acad	Acad	NNP
cord-321868-xk4yuibj	521	2	.	.	.
cord-321868-xk4yuibj	522	1	Sci	Sci	NNP
cord-321868-xk4yuibj	522	2	.	.	NNP
cord-321868-xk4yuibj	522	3	USA	USA	NNP
cord-321868-xk4yuibj	522	4	57	57	CD
cord-321868-xk4yuibj	522	5	,	,	,
cord-321868-xk4yuibj	522	6	751	751	CD
cord-321868-xk4yuibj	522	7	-	-	SYM
cord-321868-xk4yuibj	522	8	758.Randerath	758.randerath	CD
cord-321868-xk4yuibj	522	9	.	.	.
cord-321868-xk4yuibj	523	1	E.	E.	NNP
cord-321868-xk4yuibj	523	2	,	,	,
cord-321868-xk4yuibj	523	3	Gupta	Gupta	NNP
cord-321868-xk4yuibj	523	4	,	,	,
cord-321868-xk4yuibj	523	5	R.	R.	NNP
cord-321868-xk4yuibj	523	6	C.	C.	NNP
cord-321868-xk4yuibj	523	7	,	,	,
cord-321868-xk4yuibj	523	8	Chia	Chia	NNP
cord-321868-xk4yuibj	523	9	,	,	,
cord-321868-xk4yuibj	523	10	L.	L.	NNP
cord-321868-xk4yuibj	523	11	L.	L.	NNP
cord-321868-xk4yuibj	523	12	S.	S.	NNP
cord-321868-xk4yuibj	523	13	Y.	Y.	NNP
cord-321868-xk4yuibj	523	14	,	,	,
cord-321868-xk4yuibj	523	15	Chang	Chang	NNP
cord-321868-xk4yuibj	523	16	.	.	.
cord-321868-xk4yuibj	524	1	S.	S.	NNP
cord-321868-xk4yuibj	524	2	H.	H.	NNP
cord-321868-xk4yuibj	524	3	,	,	,
cord-321868-xk4yuibj	524	4	and	and	CC
cord-321868-xk4yuibj	524	5	Randerath	Randerath	NNP
cord-321868-xk4yuibj	524	6	,	,	,
cord-321868-xk4yuibj	525	1	K.	K.	NNP
cord-321868-xk4yuibj	525	2	(	(	-LRB-
cord-321868-xk4yuibj	525	3	1979	1979	CD
cord-321868-xk4yuibj	525	4	)	)	-RRB-
cord-321868-xk4yuibj	525	5	.	.	.
cord-321868-xk4yuibj	526	1	Yeast	yeast	NN
cord-321868-xk4yuibj	526	2	tRNAbr$	trnabr$	CD
cord-321868-xk4yuibj	526	3	Purification	purification	NN
cord-321868-xk4yuibj	526	4	,	,	,
cord-321868-xk4yuibj	526	5	properties	property	NNS
cord-321868-xk4yuibj	526	6	,	,	,
cord-321868-xk4yuibj	526	7	and	and	CC
cord-321868-xk4yuibj	526	8	determination	determination	NN
cord-321868-xk4yuibj	526	9	of	of	IN
cord-321868-xk4yuibj	526	10	the	the	DT
cord-321868-xk4yuibj	526	11	nucleotide	nucleotide	JJ
cord-321868-xk4yuibj	526	12	sequence	sequence	NN
cord-321868-xk4yuibj	526	13	by	by	IN
cord-321868-xk4yuibj	526	14	radioactive	radioactive	JJ
cord-321868-xk4yuibj	526	15	derivative	derivative	JJ
cord-321868-xk4yuibj	526	16	methods	method	NNS
cord-321868-xk4yuibj	526	17	.	.	.
cord-321868-xk4yuibj	527	1	Eur	Eur	NNP
cord-321868-xk4yuibj	527	2	.	.	.
cord-321868-xk4yuibj	527	3	J.	J.	NNP
cord-321868-xk4yuibj	527	4	Biochem	Biochem	NNP
cord-321868-xk4yuibj	527	5	.	.	.
cord-321868-xk4yuibj	528	1	93	93	CD
cord-321868-xk4yuibj	528	2	,	,	,
cord-321868-xk4yuibj	528	3	79	79	CD
cord-321868-xk4yuibj	528	4	-	-	SYM
cord-321868-xk4yuibj	528	5	94	94	CD
cord-321868-xk4yuibj	528	6	.	.	.
cord-321868-xk4yuibj	529	1	Sanger	Sanger	NNP
cord-321868-xk4yuibj	529	2	,	,	,
cord-321868-xk4yuibj	529	3	F.	F.	NNP
cord-321868-xk4yuibj	529	4	,	,	,
cord-321868-xk4yuibj	529	5	Nicklen	Nicklen	NNP
cord-321868-xk4yuibj	529	6	,	,	,
cord-321868-xk4yuibj	529	7	S	S	NNP
cord-321868-xk4yuibj	529	8	..	..	NFP
cord-321868-xk4yuibj	529	9	and	and	CC
cord-321868-xk4yuibj	529	10	Coulson	Coulson	NNP
cord-321868-xk4yuibj	529	11	,	,	,
cord-321868-xk4yuibj	529	12	A.	A.	NNP
cord-321868-xk4yuibj	529	13	R.	R.	NNP
cord-321868-xk4yuibj	529	14	(	(	-LRB-
cord-321868-xk4yuibj	529	15	1977	1977	CD
cord-321868-xk4yuibj	529	16	)	)	-RRB-
cord-321868-xk4yuibj	529	17	 	 	_SP