id sid tid token lemma pos cord-006393-jcj9nqfu 1 1 key key JJ cord-006393-jcj9nqfu 1 2 : : : cord-006393-jcj9nqfu 1 3 cord-006393-jcj9nqfu cord-006393-jcj9nqfu JJ cord-006393-jcj9nqfu 1 4 authors author NNS cord-006393-jcj9nqfu 1 5 : : : cord-006393-jcj9nqfu 1 6 Tutschka Tutschka NNP cord-006393-jcj9nqfu 1 7 , , , cord-006393-jcj9nqfu 1 8 Peter Peter NNP cord-006393-jcj9nqfu 1 9 J. J. NNP cord-006393-jcj9nqfu 1 10 title title NN cord-006393-jcj9nqfu 1 11 : : : cord-006393-jcj9nqfu 2 1 The the DT cord-006393-jcj9nqfu 2 2 use use NN cord-006393-jcj9nqfu 2 3 of of IN cord-006393-jcj9nqfu 2 4 immunoglobulin immunoglobulin NN cord-006393-jcj9nqfu 2 5 in in IN cord-006393-jcj9nqfu 2 6 bone bone NN cord-006393-jcj9nqfu 2 7 marrow marrow NN cord-006393-jcj9nqfu 2 8 transplantation transplantation NN cord-006393-jcj9nqfu 2 9 date date NN cord-006393-jcj9nqfu 2 10 : : : cord-006393-jcj9nqfu 2 11 1990 1990 CD cord-006393-jcj9nqfu 2 12 journal journal NN cord-006393-jcj9nqfu 2 13 : : : cord-006393-jcj9nqfu 2 14 J J NNP cord-006393-jcj9nqfu 2 15 Clin Clin NNP cord-006393-jcj9nqfu 2 16 Immunol Immunol NNP cord-006393-jcj9nqfu 2 17 DOI doi NN cord-006393-jcj9nqfu 2 18 : : : cord-006393-jcj9nqfu 3 1 10.1007 10.1007 CD cord-006393-jcj9nqfu 3 2 / / SYM cord-006393-jcj9nqfu 3 3 bf00918696 bf00918696 NNP cord-006393-jcj9nqfu 3 4 sha sha NNP cord-006393-jcj9nqfu 3 5 : : : cord-006393-jcj9nqfu 4 1 482407fc2628230fb547d8fc3d1c151c76f1abbd 482407fc2628230fb547d8fc3d1c151c76f1abbd NNP cord-006393-jcj9nqfu 4 2 doc_id doc_id CD cord-006393-jcj9nqfu 4 3 : : : cord-006393-jcj9nqfu 5 1 6393 6393 CD cord-006393-jcj9nqfu 5 2 cord_uid cord_uid NNS cord-006393-jcj9nqfu 5 3 : : : cord-006393-jcj9nqfu 6 1 jcj9nqfu jcj9nqfu NNP cord-006393-jcj9nqfu 7 1 The the DT cord-006393-jcj9nqfu 7 2 role role NN cord-006393-jcj9nqfu 7 3 of of IN cord-006393-jcj9nqfu 7 4 bone bone NN cord-006393-jcj9nqfu 7 5 marrow marrow NN cord-006393-jcj9nqfu 7 6 transplantation transplantation NN cord-006393-jcj9nqfu 7 7 is be VBZ cord-006393-jcj9nqfu 7 8 to to TO cord-006393-jcj9nqfu 7 9 restore restore VB cord-006393-jcj9nqfu 7 10 lymphohematopoietic lymphohematopoietic JJ cord-006393-jcj9nqfu 7 11 function function NN cord-006393-jcj9nqfu 7 12 of of IN cord-006393-jcj9nqfu 7 13 a a DT cord-006393-jcj9nqfu 7 14 recipient recipient NN cord-006393-jcj9nqfu 7 15 whose whose WP$ cord-006393-jcj9nqfu 7 16 marrow marrow NN cord-006393-jcj9nqfu 7 17 has have VBZ cord-006393-jcj9nqfu 7 18 been be VBN cord-006393-jcj9nqfu 7 19 destroyed destroy VBN cord-006393-jcj9nqfu 7 20 , , , cord-006393-jcj9nqfu 7 21 either either CC cord-006393-jcj9nqfu 7 22 by by IN cord-006393-jcj9nqfu 7 23 disease disease NN cord-006393-jcj9nqfu 7 24 or or CC cord-006393-jcj9nqfu 7 25 by by IN cord-006393-jcj9nqfu 7 26 the the DT cord-006393-jcj9nqfu 7 27 preparative preparative JJ cord-006393-jcj9nqfu 7 28 therapy therapy NN cord-006393-jcj9nqfu 7 29 employed employ VBN cord-006393-jcj9nqfu 7 30 in in IN cord-006393-jcj9nqfu 7 31 an an DT cord-006393-jcj9nqfu 7 32 attempt attempt NN cord-006393-jcj9nqfu 7 33 to to TO cord-006393-jcj9nqfu 7 34 eradicate eradicate VB cord-006393-jcj9nqfu 7 35 the the DT cord-006393-jcj9nqfu 7 36 patient patient NN cord-006393-jcj9nqfu 7 37 's 's POS cord-006393-jcj9nqfu 7 38 lymphohematopoietic lymphohematopoietic JJ cord-006393-jcj9nqfu 7 39 malignancy malignancy NN cord-006393-jcj9nqfu 7 40 . . . cord-006393-jcj9nqfu 8 1 The the DT cord-006393-jcj9nqfu 8 2 restoration restoration NN cord-006393-jcj9nqfu 8 3 of of IN cord-006393-jcj9nqfu 8 4 lymphohematopoietic lymphohematopoietic JJ cord-006393-jcj9nqfu 8 5 function function NN cord-006393-jcj9nqfu 8 6 through through IN cord-006393-jcj9nqfu 8 7 the the DT cord-006393-jcj9nqfu 8 8 donor donor NN cord-006393-jcj9nqfu 8 9 graft graft NN cord-006393-jcj9nqfu 8 10 occurs occur VBZ cord-006393-jcj9nqfu 8 11 in in IN cord-006393-jcj9nqfu 8 12 stages stage NNS cord-006393-jcj9nqfu 8 13 , , , cord-006393-jcj9nqfu 8 14 requires require VBZ cord-006393-jcj9nqfu 8 15 several several JJ cord-006393-jcj9nqfu 8 16 months month NNS cord-006393-jcj9nqfu 8 17 , , , cord-006393-jcj9nqfu 8 18 and and CC cord-006393-jcj9nqfu 8 19 is be VBZ cord-006393-jcj9nqfu 8 20 often often RB cord-006393-jcj9nqfu 8 21 not not RB cord-006393-jcj9nqfu 8 22 completed complete VBN cord-006393-jcj9nqfu 8 23 until until IN cord-006393-jcj9nqfu 8 24 1 1 CD cord-006393-jcj9nqfu 8 25 to to IN cord-006393-jcj9nqfu 8 26 2 2 CD cord-006393-jcj9nqfu 8 27 years year NNS cord-006393-jcj9nqfu 8 28 after after IN cord-006393-jcj9nqfu 8 29 transplantation transplantation NN cord-006393-jcj9nqfu 8 30 . . . cord-006393-jcj9nqfu 9 1 These these DT cord-006393-jcj9nqfu 9 2 sequential sequential JJ cord-006393-jcj9nqfu 9 3 steps step NNS cord-006393-jcj9nqfu 9 4 of of IN cord-006393-jcj9nqfu 9 5 immuno immuno JJ cord-006393-jcj9nqfu 9 6 - - JJ cord-006393-jcj9nqfu 9 7 reconstitution reconstitution NN cord-006393-jcj9nqfu 9 8 are be VBP cord-006393-jcj9nqfu 9 9 associated associate VBN cord-006393-jcj9nqfu 9 10 with with IN cord-006393-jcj9nqfu 9 11 a a DT cord-006393-jcj9nqfu 9 12 number number NN cord-006393-jcj9nqfu 9 13 of of IN cord-006393-jcj9nqfu 9 14 definable definable JJ cord-006393-jcj9nqfu 9 15 and and CC cord-006393-jcj9nqfu 9 16 predictable predictable JJ cord-006393-jcj9nqfu 9 17 immune immune JJ cord-006393-jcj9nqfu 9 18 deficiencies deficiency NNS cord-006393-jcj9nqfu 9 19 and and CC cord-006393-jcj9nqfu 9 20 seem seem VBP cord-006393-jcj9nqfu 9 21 to to TO cord-006393-jcj9nqfu 9 22 be be VB cord-006393-jcj9nqfu 9 23 responsible responsible JJ cord-006393-jcj9nqfu 9 24 for for IN cord-006393-jcj9nqfu 9 25 the the DT cord-006393-jcj9nqfu 9 26 pattern pattern NN cord-006393-jcj9nqfu 9 27 of of IN cord-006393-jcj9nqfu 9 28 complications complication NNS cord-006393-jcj9nqfu 9 29 that that WDT cord-006393-jcj9nqfu 9 30 emerges emerge VBZ cord-006393-jcj9nqfu 9 31 after after IN cord-006393-jcj9nqfu 9 32 transplantation transplantation NN cord-006393-jcj9nqfu 9 33 . . . cord-006393-jcj9nqfu 10 1 Most Most JJS cord-006393-jcj9nqfu 10 2 of of IN cord-006393-jcj9nqfu 10 3 these these DT cord-006393-jcj9nqfu 10 4 complications complication NNS cord-006393-jcj9nqfu 10 5 are be VBP cord-006393-jcj9nqfu 10 6 either either CC cord-006393-jcj9nqfu 10 7 the the DT cord-006393-jcj9nqfu 10 8 result result NN cord-006393-jcj9nqfu 10 9 of of IN cord-006393-jcj9nqfu 10 10 , , , cord-006393-jcj9nqfu 10 11 or or CC cord-006393-jcj9nqfu 10 12 associated associate VBN cord-006393-jcj9nqfu 10 13 with with IN cord-006393-jcj9nqfu 10 14 , , , cord-006393-jcj9nqfu 10 15 infections infection NNS cord-006393-jcj9nqfu 10 16 that that WDT cord-006393-jcj9nqfu 10 17 also also RB cord-006393-jcj9nqfu 10 18 occur occur VBP cord-006393-jcj9nqfu 10 19 in in IN cord-006393-jcj9nqfu 10 20 an an DT cord-006393-jcj9nqfu 10 21 almost almost RB cord-006393-jcj9nqfu 10 22 predictable predictable JJ cord-006393-jcj9nqfu 10 23 pattern pattern NN cord-006393-jcj9nqfu 10 24 . . . cord-006393-jcj9nqfu 11 1 In in IN cord-006393-jcj9nqfu 11 2 the the DT cord-006393-jcj9nqfu 11 3 various various JJ cord-006393-jcj9nqfu 11 4 phases phase NNS cord-006393-jcj9nqfu 11 5 of of IN cord-006393-jcj9nqfu 11 6 immune immune JJ cord-006393-jcj9nqfu 11 7 deficiency deficiency NN cord-006393-jcj9nqfu 11 8 following follow VBG cord-006393-jcj9nqfu 11 9 sequentially sequentially RB cord-006393-jcj9nqfu 11 10 after after IN cord-006393-jcj9nqfu 11 11 transplantation transplantation NN cord-006393-jcj9nqfu 11 12 , , , cord-006393-jcj9nqfu 11 13 the the DT cord-006393-jcj9nqfu 11 14 humoral humoral JJ cord-006393-jcj9nqfu 11 15 immune immune JJ cord-006393-jcj9nqfu 11 16 system system NN cord-006393-jcj9nqfu 11 17 is be VBZ cord-006393-jcj9nqfu 11 18 greatly greatly RB cord-006393-jcj9nqfu 11 19 affected affect VBN cord-006393-jcj9nqfu 11 20 , , , cord-006393-jcj9nqfu 11 21 thus thus RB cord-006393-jcj9nqfu 11 22 raising raise VBG cord-006393-jcj9nqfu 11 23 the the DT cord-006393-jcj9nqfu 11 24 possibility possibility NN cord-006393-jcj9nqfu 11 25 that that IN cord-006393-jcj9nqfu 11 26 passively passively RB cord-006393-jcj9nqfu 11 27 administered administer VBN cord-006393-jcj9nqfu 11 28 antibodies antibody NNS cord-006393-jcj9nqfu 11 29 in in IN cord-006393-jcj9nqfu 11 30 the the DT cord-006393-jcj9nqfu 11 31 form form NN cord-006393-jcj9nqfu 11 32 of of IN cord-006393-jcj9nqfu 11 33 immune immune JJ cord-006393-jcj9nqfu 11 34 globulin globulin NN cord-006393-jcj9nqfu 11 35 therapy therapy NN cord-006393-jcj9nqfu 11 36 might may MD cord-006393-jcj9nqfu 11 37 be be VB cord-006393-jcj9nqfu 11 38 beneficial beneficial JJ cord-006393-jcj9nqfu 11 39 in in IN cord-006393-jcj9nqfu 11 40 all all DT cord-006393-jcj9nqfu 11 41 phases phase NNS cord-006393-jcj9nqfu 11 42 of of IN cord-006393-jcj9nqfu 11 43 the the DT cord-006393-jcj9nqfu 11 44 marrow marrow NN cord-006393-jcj9nqfu 11 45 transplant transplant NN cord-006393-jcj9nqfu 11 46 procedure procedure NN cord-006393-jcj9nqfu 11 47 . . . cord-006393-jcj9nqfu 12 1 This this DT cord-006393-jcj9nqfu 12 2 paper paper NN cord-006393-jcj9nqfu 12 3 attempts attempt VBZ cord-006393-jcj9nqfu 12 4 to to TO cord-006393-jcj9nqfu 12 5 summarize summarize VB cord-006393-jcj9nqfu 12 6 the the DT cord-006393-jcj9nqfu 12 7 use use NN cord-006393-jcj9nqfu 12 8 of of IN cord-006393-jcj9nqfu 12 9 immune immune JJ cord-006393-jcj9nqfu 12 10 globulin globulin NN cord-006393-jcj9nqfu 12 11 preparations preparation NNS cord-006393-jcj9nqfu 12 12 in in IN cord-006393-jcj9nqfu 12 13 clinical clinical JJ cord-006393-jcj9nqfu 12 14 bone bone NN cord-006393-jcj9nqfu 12 15 marrow marrow NN cord-006393-jcj9nqfu 12 16 transplantation transplantation NN cord-006393-jcj9nqfu 12 17 , , , cord-006393-jcj9nqfu 12 18 showing show VBG cord-006393-jcj9nqfu 12 19 the the DT cord-006393-jcj9nqfu 12 20 rationale rationale NN cord-006393-jcj9nqfu 12 21 for for IN cord-006393-jcj9nqfu 12 22 and and CC cord-006393-jcj9nqfu 12 23 some some DT cord-006393-jcj9nqfu 12 24 of of IN cord-006393-jcj9nqfu 12 25 the the DT cord-006393-jcj9nqfu 12 26 results result NNS cord-006393-jcj9nqfu 12 27 of of IN cord-006393-jcj9nqfu 12 28 therapeutic therapeutic JJ cord-006393-jcj9nqfu 12 29 immune immune JJ cord-006393-jcj9nqfu 12 30 globulin globulin NN cord-006393-jcj9nqfu 12 31 administration administration NN cord-006393-jcj9nqfu 12 32 . . . cord-006393-jcj9nqfu 13 1 Intravenous intravenous JJ cord-006393-jcj9nqfu 13 2 immune immune JJ cord-006393-jcj9nqfu 13 3 globulin globulin NN cord-006393-jcj9nqfu 13 4 ( ( -LRB- cord-006393-jcj9nqfu 13 5 IV1 IV1 NNP cord-006393-jcj9nqfu 13 6 G G NNP cord-006393-jcj9nqfu 13 7 ) ) -RRB- cord-006393-jcj9nqfu 13 8 is be VBZ cord-006393-jcj9nqfu 13 9 now now RB cord-006393-jcj9nqfu 13 10 widely widely RB cord-006393-jcj9nqfu 13 11 used use VBN cord-006393-jcj9nqfu 13 12 in in IN cord-006393-jcj9nqfu 13 13 bone bone NN cord-006393-jcj9nqfu 13 14 marrow marrow NN cord-006393-jcj9nqfu 13 15 transplantation transplantation NN cord-006393-jcj9nqfu 13 16 , , , cord-006393-jcj9nqfu 13 17 despite despite IN cord-006393-jcj9nqfu 13 18 the the DT cord-006393-jcj9nqfu 13 19 fact fact NN cord-006393-jcj9nqfu 13 20 that that IN cord-006393-jcj9nqfu 13 21 critical critical JJ cord-006393-jcj9nqfu 13 22 randomized randomize VBN cord-006393-jcj9nqfu 13 23 , , , cord-006393-jcj9nqfu 13 24 controlled control VBN cord-006393-jcj9nqfu 13 25 studies study NNS cord-006393-jcj9nqfu 13 26 necessary necessary JJ cord-006393-jcj9nqfu 13 27 to to TO cord-006393-jcj9nqfu 13 28 permit permit VB cord-006393-jcj9nqfu 13 29 utilization utilization NN cord-006393-jcj9nqfu 13 30 on on IN cord-006393-jcj9nqfu 13 31 a a DT cord-006393-jcj9nqfu 13 32 scientific scientific JJ cord-006393-jcj9nqfu 13 33 basis basis NN cord-006393-jcj9nqfu 13 34 have have VBP cord-006393-jcj9nqfu 13 35 largely largely RB cord-006393-jcj9nqfu 13 36 not not RB cord-006393-jcj9nqfu 13 37 been be VBN cord-006393-jcj9nqfu 13 38 done do VBN cord-006393-jcj9nqfu 13 39 yet yet RB cord-006393-jcj9nqfu 13 40 . . . cord-006393-jcj9nqfu 14 1 This this DT cord-006393-jcj9nqfu 14 2 paper paper NN cord-006393-jcj9nqfu 14 3 attempts attempt VBZ cord-006393-jcj9nqfu 14 4 to to TO cord-006393-jcj9nqfu 14 5 give give VB cord-006393-jcj9nqfu 14 6 an an DT cord-006393-jcj9nqfu 14 7 overview overview NN cord-006393-jcj9nqfu 14 8 of of IN cord-006393-jcj9nqfu 14 9 the the DT cord-006393-jcj9nqfu 14 10 use use NN cord-006393-jcj9nqfu 14 11 of of IN cord-006393-jcj9nqfu 14 12 immune immune JJ cord-006393-jcj9nqfu 14 13 globulins globulin NNS cord-006393-jcj9nqfu 14 14 and and CC cord-006393-jcj9nqfu 14 15 the the DT cord-006393-jcj9nqfu 14 16 rationale rationale NN cord-006393-jcj9nqfu 14 17 for for IN cord-006393-jcj9nqfu 14 18 their -PRON- PRP$ cord-006393-jcj9nqfu 14 19 use use NN cord-006393-jcj9nqfu 14 20 in in IN cord-006393-jcj9nqfu 14 21 clinical clinical JJ cord-006393-jcj9nqfu 14 22 marrow marrow NN cord-006393-jcj9nqfu 14 23 transplantation transplantation NN cord-006393-jcj9nqfu 14 24 . . . cord-006393-jcj9nqfu 15 1 Prior prior RB cord-006393-jcj9nqfu 15 2 to to IN cord-006393-jcj9nqfu 15 3 bone bone NN cord-006393-jcj9nqfu 15 4 marrow marrow NN cord-006393-jcj9nqfu 15 5 transplantation transplantation NN cord-006393-jcj9nqfu 15 6 the the DT cord-006393-jcj9nqfu 15 7 recipient recipient NN cord-006393-jcj9nqfu 15 8 's 's POS cord-006393-jcj9nqfu 15 9 marrow marrow NN cord-006393-jcj9nqfu 15 10 must must MD cord-006393-jcj9nqfu 15 11 be be VB cord-006393-jcj9nqfu 15 12 completely completely RB cord-006393-jcj9nqfu 15 13 eradicated eradicate VBN cord-006393-jcj9nqfu 15 14 . . . cord-006393-jcj9nqfu 16 1 The the DT cord-006393-jcj9nqfu 16 2 hematopoietic hematopoietic JJ cord-006393-jcj9nqfu 16 3 system system NN cord-006393-jcj9nqfu 16 4 and and CC cord-006393-jcj9nqfu 16 5 the the DT cord-006393-jcj9nqfu 16 6 immune immune JJ cord-006393-jcj9nqfu 16 7 system system NN cord-006393-jcj9nqfu 16 8 are be VBP cord-006393-jcj9nqfu 16 9 88S 88 NNS cord-006393-jcj9nqfu 16 10 then then RB cord-006393-jcj9nqfu 16 11 rebuilt rebuild VBN cord-006393-jcj9nqfu 16 12 , , , cord-006393-jcj9nqfu 16 13 almost almost RB cord-006393-jcj9nqfu 16 14 in in IN cord-006393-jcj9nqfu 16 15 their -PRON- PRP$ cord-006393-jcj9nqfu 16 16 entirety entirety NN cord-006393-jcj9nqfu 16 17 . . . cord-006393-jcj9nqfu 17 1 This this DT cord-006393-jcj9nqfu 17 2 rebuilding rebuilding NN cord-006393-jcj9nqfu 17 3 of of IN cord-006393-jcj9nqfu 17 4 the the DT cord-006393-jcj9nqfu 17 5 lymphohematopoietic lymphohematopoietic JJ cord-006393-jcj9nqfu 17 6 system system NN cord-006393-jcj9nqfu 17 7 does do VBZ cord-006393-jcj9nqfu 17 8 not not RB cord-006393-jcj9nqfu 17 9 occur occur VB cord-006393-jcj9nqfu 17 10 immediately immediately RB cord-006393-jcj9nqfu 17 11 ; ; : cord-006393-jcj9nqfu 17 12 instead instead RB cord-006393-jcj9nqfu 17 13 , , , cord-006393-jcj9nqfu 17 14 it -PRON- PRP cord-006393-jcj9nqfu 17 15 goes go VBZ cord-006393-jcj9nqfu 17 16 through through IN cord-006393-jcj9nqfu 17 17 several several JJ cord-006393-jcj9nqfu 17 18 separate separate JJ cord-006393-jcj9nqfu 17 19 , , , cord-006393-jcj9nqfu 17 20 sequential sequential JJ cord-006393-jcj9nqfu 17 21 phases phase NNS cord-006393-jcj9nqfu 17 22 which which WDT cord-006393-jcj9nqfu 17 23 are be VBP cord-006393-jcj9nqfu 17 24 associated associate VBN cord-006393-jcj9nqfu 17 25 with with IN cord-006393-jcj9nqfu 17 26 an an DT cord-006393-jcj9nqfu 17 27 almost almost RB cord-006393-jcj9nqfu 17 28 predictable predictable JJ cord-006393-jcj9nqfu 17 29 pattern pattern NN cord-006393-jcj9nqfu 17 30 of of IN cord-006393-jcj9nqfu 17 31 complications complication NNS cord-006393-jcj9nqfu 17 32 , , , cord-006393-jcj9nqfu 17 33 especially especially RB cord-006393-jcj9nqfu 17 34 infectious infectious JJ cord-006393-jcj9nqfu 17 35 complications complication NNS cord-006393-jcj9nqfu 17 36 . . . cord-006393-jcj9nqfu 18 1 In in IN cord-006393-jcj9nqfu 18 2 the the DT cord-006393-jcj9nqfu 18 3 preengraftment preengraftment NN cord-006393-jcj9nqfu 18 4 phase phase NN cord-006393-jcj9nqfu 18 5 , , , cord-006393-jcj9nqfu 18 6 pancytopenia pancytopenia NNP cord-006393-jcj9nqfu 18 7 is be VBZ cord-006393-jcj9nqfu 18 8 the the DT cord-006393-jcj9nqfu 18 9 most most RBS cord-006393-jcj9nqfu 18 10 important important JJ cord-006393-jcj9nqfu 18 11 event event NN cord-006393-jcj9nqfu 18 12 . . . cord-006393-jcj9nqfu 19 1 This this DT cord-006393-jcj9nqfu 19 2 is be VBZ cord-006393-jcj9nqfu 19 3 followed follow VBN cord-006393-jcj9nqfu 19 4 by by IN cord-006393-jcj9nqfu 19 5 an an DT cord-006393-jcj9nqfu 19 6 early early JJ cord-006393-jcj9nqfu 19 7 postengraftment postengraftment NN cord-006393-jcj9nqfu 19 8 phase phase NN cord-006393-jcj9nqfu 19 9 , , , cord-006393-jcj9nqfu 19 10 characterized characterize VBN cord-006393-jcj9nqfu 19 11 immunobiologically immunobiologically RB cord-006393-jcj9nqfu 19 12 by by IN cord-006393-jcj9nqfu 19 13 acute acute JJ cord-006393-jcj9nqfu 19 14 graft graft NN cord-006393-jcj9nqfu 19 15 - - HYPH cord-006393-jcj9nqfu 19 16 vs vs IN cord-006393-jcj9nqfu 19 17 - - HYPH cord-006393-jcj9nqfu 19 18 host host NN cord-006393-jcj9nqfu 19 19 disease disease NN cord-006393-jcj9nqfu 19 20 ( ( -LRB- cord-006393-jcj9nqfu 19 21 GVHD GVHD NNP cord-006393-jcj9nqfu 19 22 ) ) -RRB- cord-006393-jcj9nqfu 19 23 and and CC cord-006393-jcj9nqfu 19 24 severe severe JJ cord-006393-jcj9nqfu 19 25 combined combine VBN cord-006393-jcj9nqfu 19 26 immunodeficiency immunodeficiency NN cord-006393-jcj9nqfu 19 27 . . . cord-006393-jcj9nqfu 20 1 The the DT cord-006393-jcj9nqfu 20 2 late late JJ cord-006393-jcj9nqfu 20 3 postengraftment postengraftment NN cord-006393-jcj9nqfu 20 4 phase phase NN cord-006393-jcj9nqfu 20 5 is be VBZ cord-006393-jcj9nqfu 20 6 characterized characterize VBN cord-006393-jcj9nqfu 20 7 by by IN cord-006393-jcj9nqfu 20 8 chronic chronic JJ cord-006393-jcj9nqfu 20 9 GVHD GVHD NNP cord-006393-jcj9nqfu 20 10 and and CC cord-006393-jcj9nqfu 20 11 immunodeficiency immunodeficiency NN cord-006393-jcj9nqfu 20 12 but but CC cord-006393-jcj9nqfu 20 13 of of IN cord-006393-jcj9nqfu 20 14 a a DT cord-006393-jcj9nqfu 20 15 more more RBR cord-006393-jcj9nqfu 20 16 humoral humoral JJ cord-006393-jcj9nqfu 20 17 type type NN cord-006393-jcj9nqfu 20 18 . . . cord-006393-jcj9nqfu 21 1 Almost almost RB cord-006393-jcj9nqfu 21 2 predictably predictably RB cord-006393-jcj9nqfu 21 3 we -PRON- PRP cord-006393-jcj9nqfu 21 4 first first RB cord-006393-jcj9nqfu 21 5 see see VBP cord-006393-jcj9nqfu 21 6 bacterial bacterial JJ cord-006393-jcj9nqfu 21 7 infections infection NNS cord-006393-jcj9nqfu 21 8 followed follow VBN cord-006393-jcj9nqfu 21 9 by by IN cord-006393-jcj9nqfu 21 10 nonbacterial nonbacterial JJ cord-006393-jcj9nqfu 21 11 , , , cord-006393-jcj9nqfu 21 12 viral viral JJ cord-006393-jcj9nqfu 21 13 infections infection NNS cord-006393-jcj9nqfu 21 14 , , , cord-006393-jcj9nqfu 21 15 particularly particularly RB cord-006393-jcj9nqfu 21 16 interstitial interstitial JJ cord-006393-jcj9nqfu 21 17 pneumonias pneumonia NNS cord-006393-jcj9nqfu 21 18 . . . cord-006393-jcj9nqfu 22 1 Later later RB cord-006393-jcj9nqfu 22 2 , , , cord-006393-jcj9nqfu 22 3 there there EX cord-006393-jcj9nqfu 22 4 are be VBP cord-006393-jcj9nqfu 22 5 some some DT cord-006393-jcj9nqfu 22 6 well well RB cord-006393-jcj9nqfu 22 7 - - HYPH cord-006393-jcj9nqfu 22 8 defined define VBN cord-006393-jcj9nqfu 22 9 infections infection NNS cord-006393-jcj9nqfu 22 10 with with IN cord-006393-jcj9nqfu 22 11 encapsulated encapsulate VBN cord-006393-jcj9nqfu 22 12 organisms organism NNS cord-006393-jcj9nqfu 22 13 , , , cord-006393-jcj9nqfu 22 14 the the DT cord-006393-jcj9nqfu 22 15 latter latter JJ cord-006393-jcj9nqfu 22 16 sometimes sometimes RB cord-006393-jcj9nqfu 22 17 even even RB cord-006393-jcj9nqfu 22 18 very very RB cord-006393-jcj9nqfu 22 19 late late JJ cord-006393-jcj9nqfu 22 20 after after IN cord-006393-jcj9nqfu 22 21 bone bone NN cord-006393-jcj9nqfu 22 22 marrow marrow NN cord-006393-jcj9nqfu 22 23 transplantation transplantation NN cord-006393-jcj9nqfu 22 24 . . . cord-006393-jcj9nqfu 23 1 In in IN cord-006393-jcj9nqfu 23 2 the the DT cord-006393-jcj9nqfu 23 3 preengraftment preengraftment NN cord-006393-jcj9nqfu 23 4 phase phase NN cord-006393-jcj9nqfu 23 5 there there EX cord-006393-jcj9nqfu 23 6 is be VBZ cord-006393-jcj9nqfu 23 7 complete complete JJ cord-006393-jcj9nqfu 23 8 aplasia aplasia NN cord-006393-jcj9nqfu 23 9 with with IN cord-006393-jcj9nqfu 23 10 absolute absolute JJ cord-006393-jcj9nqfu 23 11 neutropenia neutropenia NN cord-006393-jcj9nqfu 23 12 and and CC cord-006393-jcj9nqfu 23 13 a a DT cord-006393-jcj9nqfu 23 14 severe severe JJ cord-006393-jcj9nqfu 23 15 lymphopenia lymphopenia NN cord-006393-jcj9nqfu 23 16 . . . cord-006393-jcj9nqfu 24 1 Immunoglobulin immunoglobulin NN cord-006393-jcj9nqfu 24 2 levels level NNS cord-006393-jcj9nqfu 24 3 decrease decrease VBP cord-006393-jcj9nqfu 24 4 to to IN cord-006393-jcj9nqfu 24 5 less less JJR cord-006393-jcj9nqfu 24 6 than than IN cord-006393-jcj9nqfu 24 7 50 50 CD cord-006393-jcj9nqfu 24 8 % % NN cord-006393-jcj9nqfu 24 9 of of IN cord-006393-jcj9nqfu 24 10 normal normal JJ cord-006393-jcj9nqfu 24 11 about about RB cord-006393-jcj9nqfu 24 12 3 3 CD cord-006393-jcj9nqfu 24 13 weeks week NNS cord-006393-jcj9nqfu 24 14 after after IN cord-006393-jcj9nqfu 24 15 bone bone NN cord-006393-jcj9nqfu 24 16 marrow marrow NN cord-006393-jcj9nqfu 24 17 transplantation transplantation NN cord-006393-jcj9nqfu 24 18 . . . cord-006393-jcj9nqfu 25 1 The the DT cord-006393-jcj9nqfu 25 2 patient patient NN cord-006393-jcj9nqfu 25 3 's 's POS cord-006393-jcj9nqfu 25 4 defenses defense NNS cord-006393-jcj9nqfu 25 5 have have VBP cord-006393-jcj9nqfu 25 6 also also RB cord-006393-jcj9nqfu 25 7 been be VBN cord-006393-jcj9nqfu 25 8 weakened weaken VBN cord-006393-jcj9nqfu 25 9 by by IN cord-006393-jcj9nqfu 25 10 severe severe JJ cord-006393-jcj9nqfu 25 11 impairment impairment NN cord-006393-jcj9nqfu 25 12 of of IN cord-006393-jcj9nqfu 25 13 the the DT cord-006393-jcj9nqfu 25 14 physical physical JJ cord-006393-jcj9nqfu 25 15 barrier barrier NN cord-006393-jcj9nqfu 25 16 functions function NNS cord-006393-jcj9nqfu 25 17 due due IN cord-006393-jcj9nqfu 25 18 to to IN cord-006393-jcj9nqfu 25 19 the the DT cord-006393-jcj9nqfu 25 20 very very RB cord-006393-jcj9nqfu 25 21 aggressive aggressive JJ cord-006393-jcj9nqfu 25 22 preparative preparative JJ cord-006393-jcj9nqfu 25 23 therapy therapy NN cord-006393-jcj9nqfu 25 24 necessary necessary JJ cord-006393-jcj9nqfu 25 25 for for IN cord-006393-jcj9nqfu 25 26 bone bone NN cord-006393-jcj9nqfu 25 27 marrow marrow NN cord-006393-jcj9nqfu 25 28 transplantation transplantation NN cord-006393-jcj9nqfu 25 29 . . . cord-006393-jcj9nqfu 26 1 This this DT cord-006393-jcj9nqfu 26 2 gives give VBZ cord-006393-jcj9nqfu 26 3 rise rise NN cord-006393-jcj9nqfu 26 4 to to IN cord-006393-jcj9nqfu 26 5 infections infection NNS cord-006393-jcj9nqfu 26 6 derived derive VBN cord-006393-jcj9nqfu 26 7 primarily primarily RB cord-006393-jcj9nqfu 26 8 from from IN cord-006393-jcj9nqfu 26 9 the the DT cord-006393-jcj9nqfu 26 10 bacterial bacterial JJ cord-006393-jcj9nqfu 26 11 microflora microflora NN cord-006393-jcj9nqfu 26 12 reservoirs reservoir NNS cord-006393-jcj9nqfu 26 13 of of IN cord-006393-jcj9nqfu 26 14 the the DT cord-006393-jcj9nqfu 26 15 patient patient NN cord-006393-jcj9nqfu 26 16 , , , cord-006393-jcj9nqfu 26 17 such such JJ cord-006393-jcj9nqfu 26 18 as as IN cord-006393-jcj9nqfu 26 19 gram gram NN cord-006393-jcj9nqfu 26 20 - - HYPH cord-006393-jcj9nqfu 26 21 negative negative JJ cord-006393-jcj9nqfu 26 22 bacteria bacteria NNS cord-006393-jcj9nqfu 26 23 from from IN cord-006393-jcj9nqfu 26 24 the the DT cord-006393-jcj9nqfu 26 25 gastrointestinal gastrointestinal JJ cord-006393-jcj9nqfu 26 26 tract tract NN cord-006393-jcj9nqfu 26 27 and and CC cord-006393-jcj9nqfu 26 28 grampositive grampositive JJ cord-006393-jcj9nqfu 26 29 bacteria bacteria NNS cord-006393-jcj9nqfu 26 30 from from IN cord-006393-jcj9nqfu 26 31 the the DT cord-006393-jcj9nqfu 26 32 integument integument NN cord-006393-jcj9nqfu 26 33 such such JJ cord-006393-jcj9nqfu 26 34 as as IN cord-006393-jcj9nqfu 26 35 Staphylococcus Staphylococcus NNP cord-006393-jcj9nqfu 26 36 epidermidis epidermidi NNS cord-006393-jcj9nqfu 26 37 from from IN cord-006393-jcj9nqfu 26 38 the the DT cord-006393-jcj9nqfu 26 39 skin skin NN cord-006393-jcj9nqfu 26 40 . . . cord-006393-jcj9nqfu 27 1 In in IN cord-006393-jcj9nqfu 27 2 recent recent JJ cord-006393-jcj9nqfu 27 3 experience experience NN cord-006393-jcj9nqfu 27 4 gram gram NN cord-006393-jcj9nqfu 27 5 - - HYPH cord-006393-jcj9nqfu 27 6 positive positive JJ cord-006393-jcj9nqfu 27 7 bacteria bacteria NNS cord-006393-jcj9nqfu 27 8 have have VBP cord-006393-jcj9nqfu 27 9 replaced replace VBN cord-006393-jcj9nqfu 27 10 gram gram NN cord-006393-jcj9nqfu 27 11 - - HYPH cord-006393-jcj9nqfu 27 12 negative negative JJ cord-006393-jcj9nqfu 27 13 bacteria bacteria NNS cord-006393-jcj9nqfu 27 14 as as IN cord-006393-jcj9nqfu 27 15 the the DT cord-006393-jcj9nqfu 27 16 dominant dominant JJ cord-006393-jcj9nqfu 27 17 sources source NNS cord-006393-jcj9nqfu 27 18 of of IN cord-006393-jcj9nqfu 27 19 infection infection NN cord-006393-jcj9nqfu 27 20 . . . cord-006393-jcj9nqfu 28 1 In in IN cord-006393-jcj9nqfu 28 2 15 15 CD cord-006393-jcj9nqfu 28 3 to to TO cord-006393-jcj9nqfu 28 4 20 20 CD cord-006393-jcj9nqfu 28 5 % % NN cord-006393-jcj9nqfu 28 6 of of IN cord-006393-jcj9nqfu 28 7 patients patient NNS cord-006393-jcj9nqfu 28 8 in in IN cord-006393-jcj9nqfu 28 9 the the DT cord-006393-jcj9nqfu 28 10 preengraftment preengraftment NN cord-006393-jcj9nqfu 28 11 phase phase NN cord-006393-jcj9nqfu 28 12 bacteremia bacteremia NN cord-006393-jcj9nqfu 28 13 is be VBZ cord-006393-jcj9nqfu 28 14 present present JJ cord-006393-jcj9nqfu 28 15 , , , cord-006393-jcj9nqfu 28 16 usually usually RB cord-006393-jcj9nqfu 28 17 associated associate VBN cord-006393-jcj9nqfu 28 18 with with IN cord-006393-jcj9nqfu 28 19 sepsis sepsis NN cord-006393-jcj9nqfu 28 20 and and CC cord-006393-jcj9nqfu 28 21 circulatory circulatory JJ cord-006393-jcj9nqfu 28 22 collapse collapse NN cord-006393-jcj9nqfu 28 23 . . . cord-006393-jcj9nqfu 29 1 There there EX cord-006393-jcj9nqfu 29 2 are be VBP cord-006393-jcj9nqfu 29 3 several several JJ cord-006393-jcj9nqfu 29 4 theoretical theoretical JJ cord-006393-jcj9nqfu 29 5 ways way NNS cord-006393-jcj9nqfu 29 6 to to TO cord-006393-jcj9nqfu 29 7 prevent prevent VB cord-006393-jcj9nqfu 29 8 those those DT cord-006393-jcj9nqfu 29 9 early early JJ cord-006393-jcj9nqfu 29 10 infections infection NNS cord-006393-jcj9nqfu 29 11 . . . cord-006393-jcj9nqfu 30 1 First first RB cord-006393-jcj9nqfu 30 2 , , , cord-006393-jcj9nqfu 30 3 one one PRP cord-006393-jcj9nqfu 30 4 could could MD cord-006393-jcj9nqfu 30 5 try try VB cord-006393-jcj9nqfu 30 6 to to TO cord-006393-jcj9nqfu 30 7 develop develop VB cord-006393-jcj9nqfu 30 8 less less RBR cord-006393-jcj9nqfu 30 9 toxic toxic JJ cord-006393-jcj9nqfu 30 10 preparative preparative JJ cord-006393-jcj9nqfu 30 11 regimens regimen NNS cord-006393-jcj9nqfu 30 12 so so IN cord-006393-jcj9nqfu 30 13 that that IN cord-006393-jcj9nqfu 30 14 the the DT cord-006393-jcj9nqfu 30 15 barrier barrier NN cord-006393-jcj9nqfu 30 16 function function NN cord-006393-jcj9nqfu 30 17 was be VBD cord-006393-jcj9nqfu 30 18 less less RBR cord-006393-jcj9nqfu 30 19 impaired impaired JJ cord-006393-jcj9nqfu 30 20 . . . cord-006393-jcj9nqfu 31 1 The the DT cord-006393-jcj9nqfu 31 2 preparative preparative JJ cord-006393-jcj9nqfu 31 3 regimen regimen NN cord-006393-jcj9nqfu 31 4 that that IN cord-006393-jcj9nqfu 31 5 we -PRON- PRP cord-006393-jcj9nqfu 31 6 developed develop VBD cord-006393-jcj9nqfu 31 7 in in IN cord-006393-jcj9nqfu 31 8 our -PRON- PRP$ cord-006393-jcj9nqfu 31 9 center center NN cord-006393-jcj9nqfu 31 10 is be VBZ cord-006393-jcj9nqfu 31 11 one one CD cord-006393-jcj9nqfu 31 12 in in IN cord-006393-jcj9nqfu 31 13 which which WDT cord-006393-jcj9nqfu 31 14 total total JJ cord-006393-jcj9nqfu 31 15 - - HYPH cord-006393-jcj9nqfu 31 16 body body NN cord-006393-jcj9nqfu 31 17 irradiation irradiation NN cord-006393-jcj9nqfu 31 18 ( ( -LRB- cord-006393-jcj9nqfu 31 19 TBI TBI NNP cord-006393-jcj9nqfu 31 20 ) ) -RRB- cord-006393-jcj9nqfu 31 21 is be VBZ cord-006393-jcj9nqfu 31 22 replaced replace VBN cord-006393-jcj9nqfu 31 23 by by IN cord-006393-jcj9nqfu 31 24 a a DT cord-006393-jcj9nqfu 31 25 seemingly seemingly RB cord-006393-jcj9nqfu 31 26 less less RBR cord-006393-jcj9nqfu 31 27 toxic toxic JJ cord-006393-jcj9nqfu 31 28 agent agent NN cord-006393-jcj9nqfu 31 29 such such JJ cord-006393-jcj9nqfu 31 30 as as IN cord-006393-jcj9nqfu 31 31 busulfan busulfan NNP cord-006393-jcj9nqfu 31 32 ( ( -LRB- cord-006393-jcj9nqfu 31 33 1 1 CD cord-006393-jcj9nqfu 31 34 ) ) -RRB- cord-006393-jcj9nqfu 31 35 . . . cord-006393-jcj9nqfu 32 1 Such such PDT cord-006393-jcj9nqfu 32 2 a a DT cord-006393-jcj9nqfu 32 3 regimen regimen NN cord-006393-jcj9nqfu 32 4 permits permit VBZ cord-006393-jcj9nqfu 32 5 a a DT cord-006393-jcj9nqfu 32 6 very very RB cord-006393-jcj9nqfu 32 7 short short JJ cord-006393-jcj9nqfu 32 8 period period NN cord-006393-jcj9nqfu 32 9 of of IN cord-006393-jcj9nqfu 32 10 aplasia aplasia NNP cord-006393-jcj9nqfu 32 11 ( ( -LRB- cord-006393-jcj9nqfu 32 12 for for IN cord-006393-jcj9nqfu 32 13 only only RB cord-006393-jcj9nqfu 32 14 5 5 CD cord-006393-jcj9nqfu 32 15 to to TO cord-006393-jcj9nqfu 32 16 7 7 CD cord-006393-jcj9nqfu 32 17 days day NNS cord-006393-jcj9nqfu 32 18 ) ) -RRB- cord-006393-jcj9nqfu 32 19 , , , cord-006393-jcj9nqfu 32 20 which which WDT cord-006393-jcj9nqfu 32 21 markedly markedly RB cord-006393-jcj9nqfu 32 22 reduces reduce VBZ cord-006393-jcj9nqfu 32 23 the the DT cord-006393-jcj9nqfu 32 24 danger danger NN cord-006393-jcj9nqfu 32 25 to to IN cord-006393-jcj9nqfu 32 26 the the DT cord-006393-jcj9nqfu 32 27 patient patient NN cord-006393-jcj9nqfu 32 28 . . . cord-006393-jcj9nqfu 33 1 Second second RB cord-006393-jcj9nqfu 33 2 , , , cord-006393-jcj9nqfu 33 3 one one PRP cord-006393-jcj9nqfu 33 4 could could MD cord-006393-jcj9nqfu 33 5 try try VB cord-006393-jcj9nqfu 33 6 to to TO cord-006393-jcj9nqfu 33 7 reduce reduce VB cord-006393-jcj9nqfu 33 8 the the DT cord-006393-jcj9nqfu 33 9 patient patient NN cord-006393-jcj9nqfu 33 10 's 's POS cord-006393-jcj9nqfu 33 11 own own JJ cord-006393-jcj9nqfu 33 12 microflora microflora NN cord-006393-jcj9nqfu 33 13 reservoirs reservoir NNS cord-006393-jcj9nqfu 33 14 by by IN cord-006393-jcj9nqfu 33 15 providing provide VBG cord-006393-jcj9nqfu 33 16 a a DT cord-006393-jcj9nqfu 33 17 gnotobiotic gnotobiotic JJ cord-006393-jcj9nqfu 33 18 , , , cord-006393-jcj9nqfu 33 19 highly highly RB cord-006393-jcj9nqfu 33 20 restricted restrict VBN cord-006393-jcj9nqfu 33 21 environment environment NN cord-006393-jcj9nqfu 33 22 . . . cord-006393-jcj9nqfu 34 1 It -PRON- PRP cord-006393-jcj9nqfu 34 2 has have VBZ cord-006393-jcj9nqfu 34 3 been be VBN cord-006393-jcj9nqfu 34 4 shown show VBN cord-006393-jcj9nqfu 34 5 that that IN cord-006393-jcj9nqfu 34 6 patients patient NNS cord-006393-jcj9nqfu 34 7 with with IN cord-006393-jcj9nqfu 34 8 aplastic aplastic JJ cord-006393-jcj9nqfu 34 9 anemia anemia NN cord-006393-jcj9nqfu 34 10 who who WP cord-006393-jcj9nqfu 34 11 were be VBD cord-006393-jcj9nqfu 34 12 placed place VBN cord-006393-jcj9nqfu 34 13 in in IN cord-006393-jcj9nqfu 34 14 such such PDT cord-006393-jcj9nqfu 34 15 an an DT cord-006393-jcj9nqfu 34 16 environment environment NN cord-006393-jcj9nqfu 34 17 had have VBD cord-006393-jcj9nqfu 34 18 a a DT cord-006393-jcj9nqfu 34 19 significantly significantly RB cord-006393-jcj9nqfu 34 20 increased increase VBN cord-006393-jcj9nqfu 34 21 probability probability NN cord-006393-jcj9nqfu 34 22 of of IN cord-006393-jcj9nqfu 34 23 survival survival NN cord-006393-jcj9nqfu 34 24 following follow VBG cord-006393-jcj9nqfu 34 25 bone bone NN cord-006393-jcj9nqfu 34 26 marrow marrow NN cord-006393-jcj9nqfu 34 27 transplantation transplantation NN cord-006393-jcj9nqfu 34 28 ( ( -LRB- cord-006393-jcj9nqfu 34 29 2 2 CD cord-006393-jcj9nqfu 34 30 ) ) -RRB- cord-006393-jcj9nqfu 34 31 . . . cord-006393-jcj9nqfu 35 1 Third third RB cord-006393-jcj9nqfu 35 2 , , , cord-006393-jcj9nqfu 35 3 one one PRP cord-006393-jcj9nqfu 35 4 could could MD cord-006393-jcj9nqfu 35 5 try try VB cord-006393-jcj9nqfu 35 6 to to TO cord-006393-jcj9nqfu 35 7 bolster bolster VB cord-006393-jcj9nqfu 35 8 the the DT cord-006393-jcj9nqfu 35 9 humoral humoral JJ cord-006393-jcj9nqfu 35 10 immunity immunity NN cord-006393-jcj9nqfu 35 11 by by IN cord-006393-jcj9nqfu 35 12 passively passively RB cord-006393-jcj9nqfu 35 13 administering administer VBG cord-006393-jcj9nqfu 35 14 antibodies antibody NNS cord-006393-jcj9nqfu 35 15 against against IN cord-006393-jcj9nqfu 35 16 the the DT cord-006393-jcj9nqfu 35 17 relevant relevant JJ cord-006393-jcj9nqfu 35 18 microorganisms microorganism NNS cord-006393-jcj9nqfu 35 19 . . . cord-006393-jcj9nqfu 36 1 Commercially commercially RB cord-006393-jcj9nqfu 36 2 available available JJ cord-006393-jcj9nqfu 36 3 immune immune JJ cord-006393-jcj9nqfu 36 4 globulin globulin NN cord-006393-jcj9nqfu 36 5 preparations preparation NNS cord-006393-jcj9nqfu 36 6 do do VBP cord-006393-jcj9nqfu 36 7 indeed indeed RB cord-006393-jcj9nqfu 36 8 contain contain VB cord-006393-jcj9nqfu 36 9 antibodies antibody NNS cord-006393-jcj9nqfu 36 10 against against IN cord-006393-jcj9nqfu 36 11 a a DT cord-006393-jcj9nqfu 36 12 wide wide JJ cord-006393-jcj9nqfu 36 13 range range NN cord-006393-jcj9nqfu 36 14 of of IN cord-006393-jcj9nqfu 36 15 pathogens pathogen NNS cord-006393-jcj9nqfu 36 16 and and CC cord-006393-jcj9nqfu 36 17 toxins toxin NNS cord-006393-jcj9nqfu 36 18 , , , cord-006393-jcj9nqfu 36 19 in in IN cord-006393-jcj9nqfu 36 20 fact fact NN cord-006393-jcj9nqfu 36 21 against against IN cord-006393-jcj9nqfu 36 22 virtually virtually RB cord-006393-jcj9nqfu 36 23 all all PDT cord-006393-jcj9nqfu 36 24 the the DT cord-006393-jcj9nqfu 36 25 pathogenic pathogenic JJ cord-006393-jcj9nqfu 36 26 organisms organism NNS cord-006393-jcj9nqfu 36 27 that that WDT cord-006393-jcj9nqfu 36 28 are be VBP cord-006393-jcj9nqfu 36 29 important important JJ cord-006393-jcj9nqfu 36 30 for for IN cord-006393-jcj9nqfu 36 31 infections infection NNS cord-006393-jcj9nqfu 36 32 in in IN cord-006393-jcj9nqfu 36 33 the the DT cord-006393-jcj9nqfu 36 34 transplant transplant NN cord-006393-jcj9nqfu 36 35 setting setting NN cord-006393-jcj9nqfu 36 36 . . . cord-006393-jcj9nqfu 37 1 The the DT cord-006393-jcj9nqfu 37 2 activation activation NN cord-006393-jcj9nqfu 37 3 of of IN cord-006393-jcj9nqfu 37 4 the the DT cord-006393-jcj9nqfu 37 5 complement complement JJ cord-006393-jcj9nqfu 37 6 system system NN cord-006393-jcj9nqfu 37 7 by by IN cord-006393-jcj9nqfu 37 8 the the DT cord-006393-jcj9nqfu 37 9 administration administration NN cord-006393-jcj9nqfu 37 10 of of IN cord-006393-jcj9nqfu 37 11 immune immune JJ cord-006393-jcj9nqfu 37 12 globulins globulin NNS cord-006393-jcj9nqfu 37 13 will will MD cord-006393-jcj9nqfu 37 14 lead lead VB cord-006393-jcj9nqfu 37 15 to to IN cord-006393-jcj9nqfu 37 16 increased increase VBN cord-006393-jcj9nqfu 37 17 phagocytosis phagocytosis NN cord-006393-jcj9nqfu 37 18 and and CC cord-006393-jcj9nqfu 37 19 an an DT cord-006393-jcj9nqfu 37 20 increased increase VBN cord-006393-jcj9nqfu 37 21 granulocytochemotaxis granulocytochemotaxis NN cord-006393-jcj9nqfu 37 22 . . . cord-006393-jcj9nqfu 38 1 Immune immune JJ cord-006393-jcj9nqfu 38 2 globulins globulin NNS cord-006393-jcj9nqfu 38 3 may may MD cord-006393-jcj9nqfu 38 4 also also RB cord-006393-jcj9nqfu 38 5 prevent prevent VB cord-006393-jcj9nqfu 38 6 bacterial bacterial JJ cord-006393-jcj9nqfu 38 7 attachment attachment NN cord-006393-jcj9nqfu 38 8 on on IN cord-006393-jcj9nqfu 38 9 the the DT cord-006393-jcj9nqfu 38 10 mucosal mucosal JJ cord-006393-jcj9nqfu 38 11 surfaces surface NNS cord-006393-jcj9nqfu 38 12 because because IN cord-006393-jcj9nqfu 38 13 the the DT cord-006393-jcj9nqfu 38 14 receptor receptor NN cord-006393-jcj9nqfu 38 15 sites site NNS cord-006393-jcj9nqfu 38 16 will will MD cord-006393-jcj9nqfu 38 17 be be VB cord-006393-jcj9nqfu 38 18 occupied occupy VBN cord-006393-jcj9nqfu 38 19 by by IN cord-006393-jcj9nqfu 38 20 the the DT cord-006393-jcj9nqfu 38 21 infused infuse VBN cord-006393-jcj9nqfu 38 22 antibodies antibody NNS cord-006393-jcj9nqfu 38 23 . . . cord-006393-jcj9nqfu 39 1 Furthermore furthermore RB cord-006393-jcj9nqfu 39 2 , , , cord-006393-jcj9nqfu 39 3 some some DT cord-006393-jcj9nqfu 39 4 reasonably reasonably RB cord-006393-jcj9nqfu 39 5 wellcontrolled wellcontrolled JJ cord-006393-jcj9nqfu 39 6 studies study NNS cord-006393-jcj9nqfu 39 7 have have VBP cord-006393-jcj9nqfu 39 8 shown show VBN cord-006393-jcj9nqfu 39 9 that that IN cord-006393-jcj9nqfu 39 10 passive passive JJ cord-006393-jcj9nqfu 39 11 immune immune JJ cord-006393-jcj9nqfu 39 12 globulin globulin NN cord-006393-jcj9nqfu 39 13 therapy therapy NN cord-006393-jcj9nqfu 39 14 is be VBZ cord-006393-jcj9nqfu 39 15 effective effective JJ cord-006393-jcj9nqfu 39 16 for for IN cord-006393-jcj9nqfu 39 17 burn burn NN cord-006393-jcj9nqfu 39 18 patients patient NNS cord-006393-jcj9nqfu 39 19 as as RB cord-006393-jcj9nqfu 39 20 well well RB cord-006393-jcj9nqfu 39 21 as as IN cord-006393-jcj9nqfu 39 22 for for IN cord-006393-jcj9nqfu 39 23 trauma trauma NN cord-006393-jcj9nqfu 39 24 patients patient NNS cord-006393-jcj9nqfu 39 25 ( ( -LRB- cord-006393-jcj9nqfu 39 26 3 3 CD cord-006393-jcj9nqfu 39 27 , , , cord-006393-jcj9nqfu 39 28 4 4 CD cord-006393-jcj9nqfu 39 29 ) ) -RRB- cord-006393-jcj9nqfu 39 30 . . . cord-006393-jcj9nqfu 40 1 In in IN cord-006393-jcj9nqfu 40 2 our -PRON- PRP$ cord-006393-jcj9nqfu 40 3 own own JJ cord-006393-jcj9nqfu 40 4 program program NN cord-006393-jcj9nqfu 40 5 we -PRON- PRP cord-006393-jcj9nqfu 40 6 have have VBP cord-006393-jcj9nqfu 40 7 tried try VBN cord-006393-jcj9nqfu 40 8 to to TO cord-006393-jcj9nqfu 40 9 utilize utilize VB cord-006393-jcj9nqfu 40 10 all all PDT cord-006393-jcj9nqfu 40 11 the the DT cord-006393-jcj9nqfu 40 12 accepted accept VBN cord-006393-jcj9nqfu 40 13 measures measure NNS cord-006393-jcj9nqfu 40 14 for for IN cord-006393-jcj9nqfu 40 15 infectious infectious JJ cord-006393-jcj9nqfu 40 16 prophylaxis prophylaxis NN cord-006393-jcj9nqfu 40 17 . . . cord-006393-jcj9nqfu 41 1 We -PRON- PRP cord-006393-jcj9nqfu 41 2 studied study VBD cord-006393-jcj9nqfu 41 3 110 110 CD cord-006393-jcj9nqfu 41 4 consecutive consecutive JJ cord-006393-jcj9nqfu 41 5 transplant transplant NN cord-006393-jcj9nqfu 41 6 patients patient NNS cord-006393-jcj9nqfu 41 7 for for IN cord-006393-jcj9nqfu 41 8 whom whom WP cord-006393-jcj9nqfu 41 9 we -PRON- PRP cord-006393-jcj9nqfu 41 10 substituted substitute VBD cord-006393-jcj9nqfu 41 11 busulfan busulfan NN cord-006393-jcj9nqfu 41 12 in in IN cord-006393-jcj9nqfu 41 13 place place NN cord-006393-jcj9nqfu 41 14 of of IN cord-006393-jcj9nqfu 41 15 TBI TBI NNP cord-006393-jcj9nqfu 41 16 . . . cord-006393-jcj9nqfu 42 1 We -PRON- PRP cord-006393-jcj9nqfu 42 2 used use VBD cord-006393-jcj9nqfu 42 3 selective selective JJ cord-006393-jcj9nqfu 42 4 body body NN cord-006393-jcj9nqfu 42 5 decontamination decontamination NN cord-006393-jcj9nqfu 42 6 in in IN cord-006393-jcj9nqfu 42 7 an an DT cord-006393-jcj9nqfu 42 8 ultraclean ultraclean JJ cord-006393-jcj9nqfu 42 9 environment environment NN cord-006393-jcj9nqfu 42 10 and and CC cord-006393-jcj9nqfu 42 11 administered administer VBD cord-006393-jcj9nqfu 42 12 IVIG IVIG NNP cord-006393-jcj9nqfu 42 13 at at IN cord-006393-jcj9nqfu 42 14 a a DT cord-006393-jcj9nqfu 42 15 dose dose NN cord-006393-jcj9nqfu 42 16 of of IN cord-006393-jcj9nqfu 42 17 500 500 CD cord-006393-jcj9nqfu 42 18 mg mg NNP cord-006393-jcj9nqfu 42 19 / / SYM cord-006393-jcj9nqfu 42 20 kg kg NN cord-006393-jcj9nqfu 42 21 every every DT cord-006393-jcj9nqfu 42 22 2 2 CD cord-006393-jcj9nqfu 42 23 weeks week NNS cord-006393-jcj9nqfu 42 24 for for IN cord-006393-jcj9nqfu 42 25 a a DT cord-006393-jcj9nqfu 42 26 total total NN cord-006393-jcj9nqfu 42 27 of of IN cord-006393-jcj9nqfu 42 28 4 4 CD cord-006393-jcj9nqfu 42 29 months month NNS cord-006393-jcj9nqfu 42 30 . . . cord-006393-jcj9nqfu 43 1 With with IN cord-006393-jcj9nqfu 43 2 this this DT cord-006393-jcj9nqfu 43 3 regimen regimen NN cord-006393-jcj9nqfu 43 4 the the DT cord-006393-jcj9nqfu 43 5 incidence incidence NN cord-006393-jcj9nqfu 43 6 of of IN cord-006393-jcj9nqfu 43 7 bacteremia bacteremia NN cord-006393-jcj9nqfu 43 8 was be VBD cord-006393-jcj9nqfu 43 9 only only RB cord-006393-jcj9nqfu 43 10 2.7 2.7 CD cord-006393-jcj9nqfu 43 11 % % NN cord-006393-jcj9nqfu 43 12 and and CC cord-006393-jcj9nqfu 43 13 almost almost RB cord-006393-jcj9nqfu 43 14 half half NN cord-006393-jcj9nqfu 43 15 of of IN cord-006393-jcj9nqfu 43 16 the the DT cord-006393-jcj9nqfu 43 17 patients patient NNS cord-006393-jcj9nqfu 43 18 developed develop VBD cord-006393-jcj9nqfu 43 19 no no DT cord-006393-jcj9nqfu 43 20 fever fever NN cord-006393-jcj9nqfu 43 21 during during IN cord-006393-jcj9nqfu 43 22 aplasia aplasia NNP cord-006393-jcj9nqfu 43 23 . . . cord-006393-jcj9nqfu 44 1 Unfortunately unfortunately RB cord-006393-jcj9nqfu 44 2 , , , cord-006393-jcj9nqfu 44 3 this this DT cord-006393-jcj9nqfu 44 4 study study NN cord-006393-jcj9nqfu 44 5 was be VBD cord-006393-jcj9nqfu 44 6 not not RB cord-006393-jcj9nqfu 44 7 a a DT cord-006393-jcj9nqfu 44 8 controlled control VBN cord-006393-jcj9nqfu 44 9 one one CD cord-006393-jcj9nqfu 44 10 and and CC cord-006393-jcj9nqfu 44 11 the the DT cord-006393-jcj9nqfu 44 12 important important JJ cord-006393-jcj9nqfu 44 13 question question NN cord-006393-jcj9nqfu 44 14 if if IN cord-006393-jcj9nqfu 44 15 IVIG IVIG NNP cord-006393-jcj9nqfu 44 16 given give VBN cord-006393-jcj9nqfu 44 17 systemically systemically RB cord-006393-jcj9nqfu 44 18 wilt wilt VBP cord-006393-jcj9nqfu 44 19 reduce reduce VB cord-006393-jcj9nqfu 44 20 infectious infectious JJ cord-006393-jcj9nqfu 44 21 complications complication NNS cord-006393-jcj9nqfu 44 22 during during IN cord-006393-jcj9nqfu 44 23 aplasia aplasia NNP cord-006393-jcj9nqfu 44 24 remains remain VBZ cord-006393-jcj9nqfu 44 25 unanswered unanswered JJ cord-006393-jcj9nqfu 44 26 . . . cord-006393-jcj9nqfu 45 1 Several several JJ cord-006393-jcj9nqfu 45 2 placebo placebo NN cord-006393-jcj9nqfu 45 3 - - HYPH cord-006393-jcj9nqfu 45 4 controlled control VBN cord-006393-jcj9nqfu 45 5 trials trial NNS cord-006393-jcj9nqfu 45 6 are be VBP cord-006393-jcj9nqfu 45 7 under under IN cord-006393-jcj9nqfu 45 8 way way NN cord-006393-jcj9nqfu 45 9 in in IN cord-006393-jcj9nqfu 45 10 a a DT cord-006393-jcj9nqfu 45 11 number number NN cord-006393-jcj9nqfu 45 12 of of IN cord-006393-jcj9nqfu 45 13 transplant transplant NN cord-006393-jcj9nqfu 45 14 centers center NNS cord-006393-jcj9nqfu 45 15 to to TO cord-006393-jcj9nqfu 45 16 resolve resolve VB cord-006393-jcj9nqfu 45 17 this this DT cord-006393-jcj9nqfu 45 18 matter matter NN cord-006393-jcj9nqfu 45 19 . . . cord-006393-jcj9nqfu 46 1 From from IN cord-006393-jcj9nqfu 46 2 the the DT cord-006393-jcj9nqfu 46 3 viewpoint viewpoint NN cord-006393-jcj9nqfu 46 4 of of IN cord-006393-jcj9nqfu 46 5 the the DT cord-006393-jcj9nqfu 46 6 immunobiologist immunobiologist NN cord-006393-jcj9nqfu 46 7 , , , cord-006393-jcj9nqfu 46 8 phase phase NN cord-006393-jcj9nqfu 46 9 II II NNP cord-006393-jcj9nqfu 46 10 , , , cord-006393-jcj9nqfu 46 11 the the DT cord-006393-jcj9nqfu 46 12 phase phase NN cord-006393-jcj9nqfu 46 13 early early RB cord-006393-jcj9nqfu 46 14 after after IN cord-006393-jcj9nqfu 46 15 marrow marrow NN cord-006393-jcj9nqfu 46 16 engraftment engraftment NN cord-006393-jcj9nqfu 46 17 , , , cord-006393-jcj9nqfu 46 18 is be VBZ cord-006393-jcj9nqfu 46 19 the the DT cord-006393-jcj9nqfu 46 20 more more RBR cord-006393-jcj9nqfu 46 21 important important JJ cord-006393-jcj9nqfu 46 22 period period NN cord-006393-jcj9nqfu 46 23 . . . cord-006393-jcj9nqfu 47 1 A a DT cord-006393-jcj9nqfu 47 2 number number NN cord-006393-jcj9nqfu 47 3 of of IN cord-006393-jcj9nqfu 47 4 critical critical JJ cord-006393-jcj9nqfu 47 5 immune immune JJ cord-006393-jcj9nqfu 47 6 events event NNS cord-006393-jcj9nqfu 47 7 take take VBP cord-006393-jcj9nqfu 47 8 place place NN cord-006393-jcj9nqfu 47 9 in in IN cord-006393-jcj9nqfu 47 10 this this DT cord-006393-jcj9nqfu 47 11 second second JJ cord-006393-jcj9nqfu 47 12 phase phase NN cord-006393-jcj9nqfu 47 13 . . . cord-006393-jcj9nqfu 48 1 By by IN cord-006393-jcj9nqfu 48 2 this this DT cord-006393-jcj9nqfu 48 3 time time NN cord-006393-jcj9nqfu 48 4 host host NN cord-006393-jcj9nqfu 48 5 B b NN cord-006393-jcj9nqfu 48 6 - - HYPH cord-006393-jcj9nqfu 48 7 cell cell NN cord-006393-jcj9nqfu 48 8 immunity immunity NN cord-006393-jcj9nqfu 48 9 has have VBZ cord-006393-jcj9nqfu 48 10 disappeared disappear VBN cord-006393-jcj9nqfu 48 11 completely completely RB cord-006393-jcj9nqfu 48 12 but but CC cord-006393-jcj9nqfu 48 13 donor donor NN cord-006393-jcj9nqfu 48 14 B b NN cord-006393-jcj9nqfu 48 15 - - HYPH cord-006393-jcj9nqfu 48 16 cell cell NN cord-006393-jcj9nqfu 48 17 immunity immunity NN cord-006393-jcj9nqfu 48 18 has have VBZ cord-006393-jcj9nqfu 48 19 not not RB cord-006393-jcj9nqfu 48 20 yet yet RB cord-006393-jcj9nqfu 48 21 been be VBN cord-006393-jcj9nqfu 48 22 reestablished reestablish VBN cord-006393-jcj9nqfu 48 23 . . . cord-006393-jcj9nqfu 49 1 Adoptive adoptive JJ cord-006393-jcj9nqfu 49 2 T t NN cord-006393-jcj9nqfu 49 3 - - HYPH cord-006393-jcj9nqfu 49 4 cell cell NN cord-006393-jcj9nqfu 49 5 donor donor NN cord-006393-jcj9nqfu 49 6 immunity immunity NN cord-006393-jcj9nqfu 49 7 ( ( -LRB- cord-006393-jcj9nqfu 49 8 due due IN cord-006393-jcj9nqfu 49 9 to to IN cord-006393-jcj9nqfu 49 10 mature mature JJ cord-006393-jcj9nqfu 49 11 cells cell NNS cord-006393-jcj9nqfu 49 12 that that WDT cord-006393-jcj9nqfu 49 13 were be VBD cord-006393-jcj9nqfu 49 14 transferred transfer VBN cord-006393-jcj9nqfu 49 15 with with IN cord-006393-jcj9nqfu 49 16 the the DT cord-006393-jcj9nqfu 49 17 bone bone NN cord-006393-jcj9nqfu 49 18 marrow marrow NN cord-006393-jcj9nqfu 49 19 ) ) -RRB- cord-006393-jcj9nqfu 49 20 has have VBZ cord-006393-jcj9nqfu 49 21 disappeared disappear VBN cord-006393-jcj9nqfu 49 22 as as RB cord-006393-jcj9nqfu 49 23 well well RB cord-006393-jcj9nqfu 49 24 . . . cord-006393-jcj9nqfu 50 1 The the DT cord-006393-jcj9nqfu 50 2 function function NN cord-006393-jcj9nqfu 50 3 of of IN cord-006393-jcj9nqfu 50 4 the the DT cord-006393-jcj9nqfu 50 5 helper helper NN cord-006393-jcj9nqfu 50 6 T T NNP cord-006393-jcj9nqfu 50 7 cells cell NNS cord-006393-jcj9nqfu 50 8 is be VBZ cord-006393-jcj9nqfu 50 9 markedly markedly RB cord-006393-jcj9nqfu 50 10 impaired impair VBN cord-006393-jcj9nqfu 50 11 , , , cord-006393-jcj9nqfu 50 12 either either CC cord-006393-jcj9nqfu 50 13 because because IN cord-006393-jcj9nqfu 50 14 the the DT cord-006393-jcj9nqfu 50 15 stem stem NN cord-006393-jcj9nqfu 50 16 cells cell NNS cord-006393-jcj9nqfu 50 17 have have VBP cord-006393-jcj9nqfu 50 18 not not RB cord-006393-jcj9nqfu 50 19 yet yet RB cord-006393-jcj9nqfu 50 20 developed develop VBN cord-006393-jcj9nqfu 50 21 into into IN cord-006393-jcj9nqfu 50 22 the the DT cord-006393-jcj9nqfu 50 23 appropriate appropriate JJ cord-006393-jcj9nqfu 50 24 mature mature NN cord-006393-jcj9nqfu 50 25 T t NN cord-006393-jcj9nqfu 50 26 cells cell NNS cord-006393-jcj9nqfu 50 27 or or CC cord-006393-jcj9nqfu 50 28 because because IN cord-006393-jcj9nqfu 50 29 the the DT cord-006393-jcj9nqfu 50 30 patients patient NNS cord-006393-jcj9nqfu 50 31 are be VBP cord-006393-jcj9nqfu 50 32 receiving receive VBG cord-006393-jcj9nqfu 50 33 immunosuppressive immunosuppressive JJ cord-006393-jcj9nqfu 50 34 agents agent NNS cord-006393-jcj9nqfu 50 35 . . . cord-006393-jcj9nqfu 51 1 The the DT cord-006393-jcj9nqfu 51 2 cytotoxic cytotoxic JJ cord-006393-jcj9nqfu 51 3 effector effector NN cord-006393-jcj9nqfu 51 4 function function NN cord-006393-jcj9nqfu 51 5 is be VBZ cord-006393-jcj9nqfu 51 6 also also RB cord-006393-jcj9nqfu 51 7 impaired impair VBN cord-006393-jcj9nqfu 51 8 in in IN cord-006393-jcj9nqfu 51 9 these these DT cord-006393-jcj9nqfu 51 10 patients patient NNS cord-006393-jcj9nqfu 51 11 . . . cord-006393-jcj9nqfu 52 1 In in IN cord-006393-jcj9nqfu 52 2 addition addition NN cord-006393-jcj9nqfu 52 3 to to IN cord-006393-jcj9nqfu 52 4 these these DT cord-006393-jcj9nqfu 52 5 difficulties difficulty NNS cord-006393-jcj9nqfu 52 6 , , , cord-006393-jcj9nqfu 52 7 the the DT cord-006393-jcj9nqfu 52 8 donor donor NN cord-006393-jcj9nqfu 52 9 immune immune NN cord-006393-jcj9nqfu 52 10 system system NN cord-006393-jcj9nqfu 52 11 must must MD cord-006393-jcj9nqfu 52 12 reorient reorient VB cord-006393-jcj9nqfu 52 13 itself -PRON- PRP cord-006393-jcj9nqfu 52 14 in in IN cord-006393-jcj9nqfu 52 15 a a DT cord-006393-jcj9nqfu 52 16 different different JJ cord-006393-jcj9nqfu 52 17 MHC MHC NNP cord-006393-jcj9nqfu 52 18 - - HYPH cord-006393-jcj9nqfu 52 19 restriction restriction NN cord-006393-jcj9nqfu 52 20 setting setting NN cord-006393-jcj9nqfu 52 21 . . . cord-006393-jcj9nqfu 53 1 Furthermore furthermore RB cord-006393-jcj9nqfu 53 2 , , , cord-006393-jcj9nqfu 53 3 nonspecific nonspecific JJ cord-006393-jcj9nqfu 53 4 suppressor suppressor NN cord-006393-jcj9nqfu 53 5 cells cell NNS cord-006393-jcj9nqfu 53 6 will will MD cord-006393-jcj9nqfu 53 7 appear appear VB cord-006393-jcj9nqfu 53 8 30 30 CD cord-006393-jcj9nqfu 53 9 to to TO cord-006393-jcj9nqfu 53 10 50 50 CD cord-006393-jcj9nqfu 53 11 days day NNS cord-006393-jcj9nqfu 53 12 after after IN cord-006393-jcj9nqfu 53 13 transplantation transplantation NN cord-006393-jcj9nqfu 53 14 , , , cord-006393-jcj9nqfu 53 15 resulting result VBG cord-006393-jcj9nqfu 53 16 in in IN cord-006393-jcj9nqfu 53 17 a a DT cord-006393-jcj9nqfu 53 18 global global JJ cord-006393-jcj9nqfu 53 19 impairment impairment NN cord-006393-jcj9nqfu 53 20 of of IN cord-006393-jcj9nqfu 53 21 the the DT cord-006393-jcj9nqfu 53 22 immune immune JJ cord-006393-jcj9nqfu 53 23 defense defense NN cord-006393-jcj9nqfu 53 24 system system NN cord-006393-jcj9nqfu 53 25 . . . cord-006393-jcj9nqfu 54 1 Acute acute JJ cord-006393-jcj9nqfu 54 2 GVHD GVHD NNP cord-006393-jcj9nqfu 54 3 might may MD cord-006393-jcj9nqfu 54 4 be be VB cord-006393-jcj9nqfu 54 5 present present JJ cord-006393-jcj9nqfu 54 6 , , , cord-006393-jcj9nqfu 54 7 markedly markedly RB cord-006393-jcj9nqfu 54 8 worsening worsen VBG cord-006393-jcj9nqfu 54 9 the the DT cord-006393-jcj9nqfu 54 10 already already RB cord-006393-jcj9nqfu 54 11 present present JJ cord-006393-jcj9nqfu 54 12 immune immune JJ cord-006393-jcj9nqfu 54 13 defect defect NN cord-006393-jcj9nqfu 54 14 in in IN cord-006393-jcj9nqfu 54 15 the the DT cord-006393-jcj9nqfu 54 16 second second JJ cord-006393-jcj9nqfu 54 17 phase phase NN cord-006393-jcj9nqfu 54 18 of of IN cord-006393-jcj9nqfu 54 19 transplantation transplantation NN cord-006393-jcj9nqfu 54 20 . . . cord-006393-jcj9nqfu 55 1 An an DT cord-006393-jcj9nqfu 55 2 oversimplified oversimplified JJ cord-006393-jcj9nqfu 55 3 definition definition NN cord-006393-jcj9nqfu 55 4 of of IN cord-006393-jcj9nqfu 55 5 GVHD GVHD NNP cord-006393-jcj9nqfu 55 6 describes describe VBZ cord-006393-jcj9nqfu 55 7 it -PRON- PRP cord-006393-jcj9nqfu 55 8 as as IN cord-006393-jcj9nqfu 55 9 an an DT cord-006393-jcj9nqfu 55 10 immune immune JJ cord-006393-jcj9nqfu 55 11 attack attack NN cord-006393-jcj9nqfu 55 12 by by IN cord-006393-jcj9nqfu 55 13 donor donor NN cord-006393-jcj9nqfu 55 14 T t NN cord-006393-jcj9nqfu 55 15 lymphocytes lymphocyte NNS cord-006393-jcj9nqfu 55 16 on on IN cord-006393-jcj9nqfu 55 17 certain certain JJ cord-006393-jcj9nqfu 55 18 host host NN cord-006393-jcj9nqfu 55 19 target target NN cord-006393-jcj9nqfu 55 20 cells cell NNS cord-006393-jcj9nqfu 55 21 in in IN cord-006393-jcj9nqfu 55 22 the the DT cord-006393-jcj9nqfu 55 23 gastrointestinal gastrointestinal JJ cord-006393-jcj9nqfu 55 24 tract tract NN cord-006393-jcj9nqfu 55 25 , , , cord-006393-jcj9nqfu 55 26 the the DT cord-006393-jcj9nqfu 55 27 liver liver NN cord-006393-jcj9nqfu 55 28 , , , cord-006393-jcj9nqfu 55 29 and and CC cord-006393-jcj9nqfu 55 30 particularly particularly RB cord-006393-jcj9nqfu 55 31 , , , cord-006393-jcj9nqfu 55 32 the the DT cord-006393-jcj9nqfu 55 33 skin skin NN cord-006393-jcj9nqfu 55 34 . . . cord-006393-jcj9nqfu 56 1 The the DT cord-006393-jcj9nqfu 56 2 resultant resultant JJ cord-006393-jcj9nqfu 56 3 cutaneous cutaneous JJ cord-006393-jcj9nqfu 56 4 disease disease NN cord-006393-jcj9nqfu 56 5 is be VBZ cord-006393-jcj9nqfu 56 6 characterized characterize VBN cord-006393-jcj9nqfu 56 7 by by IN cord-006393-jcj9nqfu 56 8 discoloration discoloration NN cord-006393-jcj9nqfu 56 9 and and CC cord-006393-jcj9nqfu 56 10 desquamation desquamation NN cord-006393-jcj9nqfu 56 11 followed follow VBN cord-006393-jcj9nqfu 56 12 by by IN cord-006393-jcj9nqfu 56 13 severe severe JJ cord-006393-jcj9nqfu 56 14 erythema erythema NN cord-006393-jcj9nqfu 56 15 together together RB cord-006393-jcj9nqfu 56 16 with with IN cord-006393-jcj9nqfu 56 17 epidermal epidermal JJ cord-006393-jcj9nqfu 56 18 lysis lysis NN cord-006393-jcj9nqfu 56 19 in in IN cord-006393-jcj9nqfu 56 20 which which WDT cord-006393-jcj9nqfu 56 21 the the DT cord-006393-jcj9nqfu 56 22 entire entire JJ cord-006393-jcj9nqfu 56 23 integument integument NN cord-006393-jcj9nqfu 56 24 is be VBZ cord-006393-jcj9nqfu 56 25 affected affect VBN cord-006393-jcj9nqfu 56 26 . . . cord-006393-jcj9nqfu 57 1 A a DT cord-006393-jcj9nqfu 57 2 number number NN cord-006393-jcj9nqfu 57 3 of of IN cord-006393-jcj9nqfu 57 4 infectious infectious JJ cord-006393-jcj9nqfu 57 5 complications complication NNS cord-006393-jcj9nqfu 57 6 are be VBP cord-006393-jcj9nqfu 57 7 associated associate VBN cord-006393-jcj9nqfu 57 8 with with IN cord-006393-jcj9nqfu 57 9 acute acute JJ cord-006393-jcj9nqfu 57 10 GVHD GVHD NNP cord-006393-jcj9nqfu 57 11 , , , cord-006393-jcj9nqfu 57 12 especially especially RB cord-006393-jcj9nqfu 57 13 those those DT cord-006393-jcj9nqfu 57 14 due due JJ cord-006393-jcj9nqfu 57 15 to to IN cord-006393-jcj9nqfu 57 16 resistant resistant JJ cord-006393-jcj9nqfu 57 17 gram gram NN cord-006393-jcj9nqfu 57 18 - - HYPH cord-006393-jcj9nqfu 57 19 negative negative JJ cord-006393-jcj9nqfu 57 20 bacteria bacteria NNS cord-006393-jcj9nqfu 57 21 , , , cord-006393-jcj9nqfu 57 22 but but CC cord-006393-jcj9nqfu 57 23 also also RB cord-006393-jcj9nqfu 57 24 Candida Candida NNP cord-006393-jcj9nqfu 57 25 infections infection NNS cord-006393-jcj9nqfu 57 26 and and CC cord-006393-jcj9nqfu 57 27 gram gram NN cord-006393-jcj9nqfu 57 28 - - HYPH cord-006393-jcj9nqfu 57 29 positive positive JJ cord-006393-jcj9nqfu 57 30 infections infection NNS cord-006393-jcj9nqfu 57 31 caused cause VBN cord-006393-jcj9nqfu 57 32 by by IN cord-006393-jcj9nqfu 57 33 Corynebacteria Corynebacteria NNP cord-006393-jcj9nqfu 57 34 . . . cord-006393-jcj9nqfu 58 1 Interstitial interstitial JJ cord-006393-jcj9nqfu 58 2 pneumonia pneumonia NN cord-006393-jcj9nqfu 58 3 , , , cord-006393-jcj9nqfu 58 4 a a DT cord-006393-jcj9nqfu 58 5 very very RB cord-006393-jcj9nqfu 58 6 important important JJ cord-006393-jcj9nqfu 58 7 infection infection NN cord-006393-jcj9nqfu 58 8 which which WDT cord-006393-jcj9nqfu 58 9 is be VBZ cord-006393-jcj9nqfu 58 10 often often RB cord-006393-jcj9nqfu 58 11 associated associate VBN cord-006393-jcj9nqfu 58 12 with with IN cord-006393-jcj9nqfu 58 13 acute acute JJ cord-006393-jcj9nqfu 58 14 GVHD GVHD NNP cord-006393-jcj9nqfu 58 15 , , , cord-006393-jcj9nqfu 58 16 is be VBZ cord-006393-jcj9nqfu 58 17 discussed discuss VBN cord-006393-jcj9nqfu 58 18 shortly shortly RB cord-006393-jcj9nqfu 58 19 . . . cord-006393-jcj9nqfu 59 1 There there EX cord-006393-jcj9nqfu 59 2 is be VBZ cord-006393-jcj9nqfu 59 3 an an DT cord-006393-jcj9nqfu 59 4 intricate intricate JJ cord-006393-jcj9nqfu 59 5 relationship relationship NN cord-006393-jcj9nqfu 59 6 between between IN cord-006393-jcj9nqfu 59 7 GVHD GVHD NNP cord-006393-jcj9nqfu 59 8 and and CC cord-006393-jcj9nqfu 59 9 infections infection NNS cord-006393-jcj9nqfu 59 10 , , , cord-006393-jcj9nqfu 59 11 Germ germ NN cord-006393-jcj9nqfu 59 12 - - HYPH cord-006393-jcj9nqfu 59 13 free free JJ cord-006393-jcj9nqfu 59 14 rodents rodent NNS cord-006393-jcj9nqfu 59 15 which which WDT cord-006393-jcj9nqfu 59 16 are be VBP cord-006393-jcj9nqfu 59 17 transplanted transplant VBN cord-006393-jcj9nqfu 59 18 in in IN cord-006393-jcj9nqfu 59 19 a a DT cord-006393-jcj9nqfu 59 20 germ germ NN cord-006393-jcj9nqfu 59 21 - - HYPH cord-006393-jcj9nqfu 59 22 free free JJ cord-006393-jcj9nqfu 59 23 environment environment NN cord-006393-jcj9nqfu 59 24 will will MD cord-006393-jcj9nqfu 59 25 not not RB cord-006393-jcj9nqfu 59 26 develop develop VB cord-006393-jcj9nqfu 59 27 GVHD GVHD NNP cord-006393-jcj9nqfu 59 28 even even RB cord-006393-jcj9nqfu 59 29 if if IN cord-006393-jcj9nqfu 59 30 they -PRON- PRP cord-006393-jcj9nqfu 59 31 receive receive VBP cord-006393-jcj9nqfu 59 32 a a DT cord-006393-jcj9nqfu 59 33 mismatched mismatched JJ cord-006393-jcj9nqfu 59 34 transplant transplant NN cord-006393-jcj9nqfu 59 35 . . . cord-006393-jcj9nqfu 60 1 Conversely conversely RB cord-006393-jcj9nqfu 60 2 , , , cord-006393-jcj9nqfu 60 3 intentional intentional JJ cord-006393-jcj9nqfu 60 4 contamination contamination NN cord-006393-jcj9nqfu 60 5 of of IN cord-006393-jcj9nqfu 60 6 these these DT cord-006393-jcj9nqfu 60 7 chimeric chimeric JJ cord-006393-jcj9nqfu 60 8 animals animal NNS cord-006393-jcj9nqfu 60 9 will will MD cord-006393-jcj9nqfu 60 10 cause cause VB cord-006393-jcj9nqfu 60 11 GVHD GVHD NNP cord-006393-jcj9nqfu 60 12 ( ( -LRB- cord-006393-jcj9nqfu 60 13 5 5 CD cord-006393-jcj9nqfu 60 14 ) ) -RRB- cord-006393-jcj9nqfu 60 15 . . . cord-006393-jcj9nqfu 61 1 Patients patient NNS cord-006393-jcj9nqfu 61 2 in in IN cord-006393-jcj9nqfu 61 3 germ germ NN cord-006393-jcj9nqfu 61 4 - - HYPH cord-006393-jcj9nqfu 61 5 free free JJ cord-006393-jcj9nqfu 61 6 environments environment NNS cord-006393-jcj9nqfu 61 7 have have VBP cord-006393-jcj9nqfu 61 8 a a DT cord-006393-jcj9nqfu 61 9 reduced reduce VBN cord-006393-jcj9nqfu 61 10 incidence incidence NN cord-006393-jcj9nqfu 61 11 of of IN cord-006393-jcj9nqfu 61 12 severe severe JJ cord-006393-jcj9nqfu 61 13 GVHD GVHD NNP cord-006393-jcj9nqfu 61 14 . . . cord-006393-jcj9nqfu 62 1 Furthermore furthermore RB cord-006393-jcj9nqfu 62 2 , , , cord-006393-jcj9nqfu 62 3 cutaneous cutaneous JJ cord-006393-jcj9nqfu 62 4 GVHD GVHD NNP cord-006393-jcj9nqfu 62 5 will will MD cord-006393-jcj9nqfu 62 6 develop develop VB cord-006393-jcj9nqfu 62 7 in in IN cord-006393-jcj9nqfu 62 8 areas area NNS cord-006393-jcj9nqfu 62 9 which which WDT cord-006393-jcj9nqfu 62 10 have have VBP cord-006393-jcj9nqfu 62 11 tissue tissue NN cord-006393-jcj9nqfu 62 12 damage damage NN cord-006393-jcj9nqfu 62 13 , , , cord-006393-jcj9nqfu 62 14 especially especially RB cord-006393-jcj9nqfu 62 15 if if IN cord-006393-jcj9nqfu 62 16 this this DT cord-006393-jcj9nqfu 62 17 damage damage NN cord-006393-jcj9nqfu 62 18 is be VBZ cord-006393-jcj9nqfu 62 19 caused cause VBN cord-006393-jcj9nqfu 62 20 by by IN cord-006393-jcj9nqfu 62 21 a a DT cord-006393-jcj9nqfu 62 22 virus virus NN cord-006393-jcj9nqfu 62 23 . . . cord-006393-jcj9nqfu 63 1 Finally finally RB cord-006393-jcj9nqfu 63 2 , , , cord-006393-jcj9nqfu 63 3 viral viral JJ cord-006393-jcj9nqfu 63 4 infections infection NNS cord-006393-jcj9nqfu 63 5 are be VBP cord-006393-jcj9nqfu 63 6 known know VBN cord-006393-jcj9nqfu 63 7 to to TO cord-006393-jcj9nqfu 63 8 trigger trigger VB cord-006393-jcj9nqfu 63 9 GVHD GVHD NNP cord-006393-jcj9nqfu 63 10 in in IN cord-006393-jcj9nqfu 63 11 rats rat NNS cord-006393-jcj9nqfu 63 12 ( ( -LRB- cord-006393-jcj9nqfu 63 13 6 6 CD cord-006393-jcj9nqfu 63 14 ) ) -RRB- cord-006393-jcj9nqfu 63 15 . . . cord-006393-jcj9nqfu 64 1 Could Could MD cord-006393-jcj9nqfu 64 2 IVIG IVIG NNP cord-006393-jcj9nqfu 64 3 have have VB cord-006393-jcj9nqfu 64 4 a a DT cord-006393-jcj9nqfu 64 5 role role NN cord-006393-jcj9nqfu 64 6 in in IN cord-006393-jcj9nqfu 64 7 preventing prevent VBG cord-006393-jcj9nqfu 64 8 GVHD GVHD NNP cord-006393-jcj9nqfu 64 9 ? ? . cord-006393-jcj9nqfu 65 1 Animal animal NN cord-006393-jcj9nqfu 65 2 studies study NNS cord-006393-jcj9nqfu 65 3 , , , cord-006393-jcj9nqfu 65 4 including include VBG cord-006393-jcj9nqfu 65 5 some some DT cord-006393-jcj9nqfu 65 6 from from IN cord-006393-jcj9nqfu 65 7 our -PRON- PRP$ cord-006393-jcj9nqfu 65 8 laboratory laboratory NN cord-006393-jcj9nqfu 65 9 , , , cord-006393-jcj9nqfu 65 10 indicate indicate VBP cord-006393-jcj9nqfu 65 11 that that IN cord-006393-jcj9nqfu 65 12 when when WRB cord-006393-jcj9nqfu 65 13 antibody antibody NN cord-006393-jcj9nqfu 65 14 against against IN cord-006393-jcj9nqfu 65 15 Escherichia Escherichia NNP cord-006393-jcj9nqfu 65 16 coli coli NNS cord-006393-jcj9nqfu 65 17 is be VBZ cord-006393-jcj9nqfu 65 18 given give VBN cord-006393-jcj9nqfu 65 19 systemically systemically RB cord-006393-jcj9nqfu 65 20 to to IN cord-006393-jcj9nqfu 65 21 rats rat NNS cord-006393-jcj9nqfu 65 22 , , , cord-006393-jcj9nqfu 65 23 it -PRON- PRP cord-006393-jcj9nqfu 65 24 will will MD cord-006393-jcj9nqfu 65 25 reduce reduce VB cord-006393-jcj9nqfu 65 26 GVHD GVHD NNP cord-006393-jcj9nqfu 65 27 in in IN cord-006393-jcj9nqfu 65 28 matched match VBN cord-006393-jcj9nqfu 65 29 bone bone NN cord-006393-jcj9nqfu 65 30 marrow marrow NN cord-006393-jcj9nqfu 65 31 transplants transplant NNS cord-006393-jcj9nqfu 65 32 . . . cord-006393-jcj9nqfu 66 1 This this DT cord-006393-jcj9nqfu 66 2 suggests suggest VBZ cord-006393-jcj9nqfu 66 3 that that IN cord-006393-jcj9nqfu 66 4 IVIG IVIG NNP cord-006393-jcj9nqfu 66 5 might may MD cord-006393-jcj9nqfu 66 6 have have VB cord-006393-jcj9nqfu 66 7 some some DT cord-006393-jcj9nqfu 66 8 influence influence NN cord-006393-jcj9nqfu 66 9 on on IN cord-006393-jcj9nqfu 66 10 GVHD GVHD NNP cord-006393-jcj9nqfu 66 11 . . . cord-006393-jcj9nqfu 67 1 It -PRON- PRP cord-006393-jcj9nqfu 67 2 is be VBZ cord-006393-jcj9nqfu 67 3 possible possible JJ cord-006393-jcj9nqfu 67 4 that that IN cord-006393-jcj9nqfu 67 5 IVIG IVIG NNP cord-006393-jcj9nqfu 67 6 could could MD cord-006393-jcj9nqfu 67 7 act act VB cord-006393-jcj9nqfu 67 8 as as IN cord-006393-jcj9nqfu 67 9 an an DT cord-006393-jcj9nqfu 67 10 immune immune JJ cord-006393-jcj9nqfu 67 11 modulator modulator NN cord-006393-jcj9nqfu 67 12 . . . cord-006393-jcj9nqfu 68 1 An an DT cord-006393-jcj9nqfu 68 2 Fcdependent Fcdependent NNP cord-006393-jcj9nqfu 68 3 blockade blockade NN cord-006393-jcj9nqfu 68 4 of of IN cord-006393-jcj9nqfu 68 5 reticuloendothelial reticuloendothelial JJ cord-006393-jcj9nqfu 68 6 structures structure NNS cord-006393-jcj9nqfu 68 7 by by IN cord-006393-jcj9nqfu 68 8 IVIG IVIG NNP cord-006393-jcj9nqfu 68 9 has have VBZ cord-006393-jcj9nqfu 68 10 been be VBN cord-006393-jcj9nqfu 68 11 described describe VBN cord-006393-jcj9nqfu 68 12 and and CC cord-006393-jcj9nqfu 68 13 studies study NNS cord-006393-jcj9nqfu 68 14 in in IN cord-006393-jcj9nqfu 68 15 animal animal NN cord-006393-jcj9nqfu 68 16 models model NNS cord-006393-jcj9nqfu 68 17 have have VBP cord-006393-jcj9nqfu 68 18 shown show VBN cord-006393-jcj9nqfu 68 19 that that IN cord-006393-jcj9nqfu 68 20 immune immune JJ cord-006393-jcj9nqfu 68 21 globulins globulin NNS cord-006393-jcj9nqfu 68 22 can can MD cord-006393-jcj9nqfu 68 23 induce induce VB cord-006393-jcj9nqfu 68 24 antiidiotypic antiidiotypic JJ cord-006393-jcj9nqfu 68 25 regulation regulation NN cord-006393-jcj9nqfu 68 26 . . . cord-006393-jcj9nqfu 69 1 Also also RB cord-006393-jcj9nqfu 69 2 on on IN cord-006393-jcj9nqfu 69 3 the the DT cord-006393-jcj9nqfu 69 4 basis basis NN cord-006393-jcj9nqfu 69 5 of of IN cord-006393-jcj9nqfu 69 6 animal animal NN cord-006393-jcj9nqfu 69 7 models model NNS cord-006393-jcj9nqfu 69 8 , , , cord-006393-jcj9nqfu 69 9 we -PRON- PRP cord-006393-jcj9nqfu 69 10 know know VBP cord-006393-jcj9nqfu 69 11 that that IN cord-006393-jcj9nqfu 69 12 suppressorcell suppressorcell JJ cord-006393-jcj9nqfu 69 13 function function NN cord-006393-jcj9nqfu 69 14 can can MD cord-006393-jcj9nqfu 69 15 be be VB cord-006393-jcj9nqfu 69 16 restored restore VBN cord-006393-jcj9nqfu 69 17 with with IN cord-006393-jcj9nqfu 69 18 the the DT cord-006393-jcj9nqfu 69 19 use use NN cord-006393-jcj9nqfu 69 20 of of IN cord-006393-jcj9nqfu 69 21 IVIG IVIG NNP cord-006393-jcj9nqfu 69 22 . . . cord-006393-jcj9nqfu 70 1 Since since IN cord-006393-jcj9nqfu 70 2 specific specific JJ cord-006393-jcj9nqfu 70 3 suppressor suppressor NN cord-006393-jcj9nqfu 70 4 cells cell NNS cord-006393-jcj9nqfu 70 5 are be VBP cord-006393-jcj9nqfu 70 6 important important JJ cord-006393-jcj9nqfu 70 7 in in IN cord-006393-jcj9nqfu 70 8 counteracting counteract VBG cord-006393-jcj9nqfu 70 9 GVHD GVHD NNP cord-006393-jcj9nqfu 70 10 , , , cord-006393-jcj9nqfu 70 11 this this DT cord-006393-jcj9nqfu 70 12 is be VBZ cord-006393-jcj9nqfu 70 13 another another DT cord-006393-jcj9nqfu 70 14 instance instance NN cord-006393-jcj9nqfu 70 15 in in IN cord-006393-jcj9nqfu 70 16 which which WDT cord-006393-jcj9nqfu 70 17 IVIG IVIG NNP cord-006393-jcj9nqfu 70 18 may may MD cord-006393-jcj9nqfu 70 19 play play VB cord-006393-jcj9nqfu 70 20 a a DT cord-006393-jcj9nqfu 70 21 role role NN cord-006393-jcj9nqfu 70 22 , , , cord-006393-jcj9nqfu 70 23 at at IN cord-006393-jcj9nqfu 70 24 least least JJS cord-006393-jcj9nqfu 70 25 in in IN cord-006393-jcj9nqfu 70 26 theory theory NN cord-006393-jcj9nqfu 70 27 . . . cord-006393-jcj9nqfu 71 1 The the DT cord-006393-jcj9nqfu 71 2 most most RBS cord-006393-jcj9nqfu 71 3 important important JJ cord-006393-jcj9nqfu 71 4 effect effect NN cord-006393-jcj9nqfu 71 5 of of IN cord-006393-jcj9nqfu 71 6 IVIG IVIG NNP cord-006393-jcj9nqfu 71 7 , , , cord-006393-jcj9nqfu 71 8 however however RB cord-006393-jcj9nqfu 71 9 , , , cord-006393-jcj9nqfu 71 10 might may MD cord-006393-jcj9nqfu 71 11 be be VB cord-006393-jcj9nqfu 71 12 an an DT cord-006393-jcj9nqfu 71 13 indirect indirect JJ cord-006393-jcj9nqfu 71 14 one one NN cord-006393-jcj9nqfu 71 15 by by IN cord-006393-jcj9nqfu 71 16 which which WDT cord-006393-jcj9nqfu 71 17 prevention prevention NN cord-006393-jcj9nqfu 71 18 of of IN cord-006393-jcj9nqfu 71 19 infections infection NNS cord-006393-jcj9nqfu 71 20 will will MD cord-006393-jcj9nqfu 71 21 , , , cord-006393-jcj9nqfu 71 22 in in IN cord-006393-jcj9nqfu 71 23 turn turn NN cord-006393-jcj9nqfu 71 24 , , , cord-006393-jcj9nqfu 71 25 avert avert VB cord-006393-jcj9nqfu 71 26 the the DT cord-006393-jcj9nqfu 71 27 trigger trigger NN cord-006393-jcj9nqfu 71 28 for for IN cord-006393-jcj9nqfu 71 29 GVHD GVHD NNP cord-006393-jcj9nqfu 71 30 . . . cord-006393-jcj9nqfu 72 1 Although although IN cord-006393-jcj9nqfu 72 2 at at IN cord-006393-jcj9nqfu 72 3 the the DT cord-006393-jcj9nqfu 72 4 present present JJ cord-006393-jcj9nqfu 72 5 time time NN cord-006393-jcj9nqfu 72 6 GVHD GVHD NNP cord-006393-jcj9nqfu 72 7 is be VBZ cord-006393-jcj9nqfu 72 8 no no RB cord-006393-jcj9nqfu 72 9 longer long RBR cord-006393-jcj9nqfu 72 10 a a DT cord-006393-jcj9nqfu 72 11 major major JJ cord-006393-jcj9nqfu 72 12 problem problem NN cord-006393-jcj9nqfu 72 13 in in IN cord-006393-jcj9nqfu 72 14 most most JJS cord-006393-jcj9nqfu 72 15 transplant transplant NN cord-006393-jcj9nqfu 72 16 programs program NNS cord-006393-jcj9nqfu 72 17 , , , cord-006393-jcj9nqfu 72 18 GVHDassociated gvhdassociate VBD cord-006393-jcj9nqfu 72 19 viral viral JJ cord-006393-jcj9nqfu 72 20 infections infection NNS cord-006393-jcj9nqfu 72 21 are be VBP cord-006393-jcj9nqfu 72 22 still still RB cord-006393-jcj9nqfu 72 23 of of IN cord-006393-jcj9nqfu 72 24 great great JJ cord-006393-jcj9nqfu 72 25 importance importance NN cord-006393-jcj9nqfu 72 26 . . . cord-006393-jcj9nqfu 73 1 The the DT cord-006393-jcj9nqfu 73 2 two two CD cord-006393-jcj9nqfu 73 3 major major JJ cord-006393-jcj9nqfu 73 4 viral viral JJ cord-006393-jcj9nqfu 73 5 infections infection NNS cord-006393-jcj9nqfu 73 6 in in IN cord-006393-jcj9nqfu 73 7 phase phase NN cord-006393-jcj9nqfu 73 8 1I 1i CD cord-006393-jcj9nqfu 73 9 express express VBP cord-006393-jcj9nqfu 73 10 themselves -PRON- PRP cord-006393-jcj9nqfu 73 11 either either CC cord-006393-jcj9nqfu 73 12 as as IN cord-006393-jcj9nqfu 73 13 interstitial interstitial JJ cord-006393-jcj9nqfu 73 14 pneumonia pneumonia NN cord-006393-jcj9nqfu 73 15 or or CC cord-006393-jcj9nqfu 73 16 as as IN cord-006393-jcj9nqfu 73 17 a a DT cord-006393-jcj9nqfu 73 18 hemorrhagic hemorrhagic JJ cord-006393-jcj9nqfu 73 19 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 73 20 not not RB cord-006393-jcj9nqfu 73 21 unlike unlike IN cord-006393-jcj9nqfu 73 22 the the DT cord-006393-jcj9nqfu 73 23 necrotizing necrotize VBG cord-006393-jcj9nqfu 73 24 enterocolitis enterocolitis NN cord-006393-jcj9nqfu 73 25 in in IN cord-006393-jcj9nqfu 73 26 the the DT cord-006393-jcj9nqfu 73 27 pediatric pediatric JJ cord-006393-jcj9nqfu 73 28 population population NN cord-006393-jcj9nqfu 73 29 which which WDT cord-006393-jcj9nqfu 73 30 is be VBZ cord-006393-jcj9nqfu 73 31 described describe VBN cord-006393-jcj9nqfu 73 32 elsewhere elsewhere RB cord-006393-jcj9nqfu 73 33 in in IN cord-006393-jcj9nqfu 73 34 this this DT cord-006393-jcj9nqfu 73 35 issue issue NN cord-006393-jcj9nqfu 73 36 . . . cord-006393-jcj9nqfu 74 1 The the DT cord-006393-jcj9nqfu 74 2 interstitial interstitial JJ cord-006393-jcj9nqfu 74 3 infiltrate infiltrate NN cord-006393-jcj9nqfu 74 4 of of IN cord-006393-jcj9nqfu 74 5 the the DT cord-006393-jcj9nqfu 74 6 early early JJ cord-006393-jcj9nqfu 74 7 pneumonia pneumonia NN cord-006393-jcj9nqfu 74 8 quickly quickly RB cord-006393-jcj9nqfu 74 9 spreads spread VBZ cord-006393-jcj9nqfu 74 10 over over IN cord-006393-jcj9nqfu 74 11 both both DT cord-006393-jcj9nqfu 74 12 lungs lung NNS cord-006393-jcj9nqfu 74 13 , , , cord-006393-jcj9nqfu 74 14 often often RB cord-006393-jcj9nqfu 74 15 resulting result VBG cord-006393-jcj9nqfu 74 16 in in IN cord-006393-jcj9nqfu 74 17 a a DT cord-006393-jcj9nqfu 74 18 complete complete JJ cord-006393-jcj9nqfu 74 19 whitening whitening NN cord-006393-jcj9nqfu 75 1 ~f ~f NNP cord-006393-jcj9nqfu 75 2 the the DT cord-006393-jcj9nqfu 75 3 lungs lung NNS cord-006393-jcj9nqfu 75 4 which which WDT cord-006393-jcj9nqfu 75 5 is be VBZ cord-006393-jcj9nqfu 75 6 accompanied accompany VBN cord-006393-jcj9nqfu 75 7 by by IN cord-006393-jcj9nqfu 75 8 severe severe JJ cord-006393-jcj9nqfu 75 9 adult adult NN cord-006393-jcj9nqfu 75 10 respiratory respiratory JJ cord-006393-jcj9nqfu 75 11 disease disease NN cord-006393-jcj9nqfu 75 12 syndrome syndrome NN cord-006393-jcj9nqfu 75 13 ( ( -LRB- cord-006393-jcj9nqfu 75 14 ARDS ARDS NNP cord-006393-jcj9nqfu 75 15 ) ) -RRB- cord-006393-jcj9nqfu 75 16 . . . cord-006393-jcj9nqfu 76 1 In in IN cord-006393-jcj9nqfu 76 2 at at RB cord-006393-jcj9nqfu 76 3 least least JJS cord-006393-jcj9nqfu 76 4 half half PDT cord-006393-jcj9nqfu 76 5 the the DT cord-006393-jcj9nqfu 76 6 cases case NNS cord-006393-jcj9nqfu 76 7 , , , cord-006393-jcj9nqfu 76 8 cytomegalovirus cytomegalovirus NNP cord-006393-jcj9nqfu 76 9 ( ( -LRB- cord-006393-jcj9nqfu 76 10 CMV CMV NNP cord-006393-jcj9nqfu 76 11 ) ) -RRB- cord-006393-jcj9nqfu 76 12 is be VBZ cord-006393-jcj9nqfu 76 13 associated associate VBN cord-006393-jcj9nqfu 76 14 with with IN cord-006393-jcj9nqfu 76 15 ARDS ARDS NNP cord-006393-jcj9nqfu 76 16 . . . cord-006393-jcj9nqfu 77 1 The the DT cord-006393-jcj9nqfu 77 2 incidence incidence NN cord-006393-jcj9nqfu 77 3 of of IN cord-006393-jcj9nqfu 77 4 this this DT cord-006393-jcj9nqfu 77 5 disease disease NN cord-006393-jcj9nqfu 77 6 varies vary VBZ cord-006393-jcj9nqfu 77 7 between between IN cord-006393-jcj9nqfu 77 8 15 15 CD cord-006393-jcj9nqfu 77 9 and and CC cord-006393-jcj9nqfu 77 10 40 40 CD cord-006393-jcj9nqfu 77 11 % % NN cord-006393-jcj9nqfu 77 12 , , , cord-006393-jcj9nqfu 77 13 with with IN cord-006393-jcj9nqfu 77 14 CMV CMV NNP cord-006393-jcj9nqfu 77 15 being be VBG cord-006393-jcj9nqfu 77 16 responsible responsible JJ cord-006393-jcj9nqfu 77 17 for for IN cord-006393-jcj9nqfu 77 18 about about IN cord-006393-jcj9nqfu 77 19 half half NN cord-006393-jcj9nqfu 77 20 of of IN cord-006393-jcj9nqfu 77 21 the the DT cord-006393-jcj9nqfu 77 22 cases case NNS cord-006393-jcj9nqfu 77 23 . . . cord-006393-jcj9nqfu 78 1 When when WRB cord-006393-jcj9nqfu 78 2 CMV CMV NNP cord-006393-jcj9nqfu 78 3 is be VBZ cord-006393-jcj9nqfu 78 4 the the DT cord-006393-jcj9nqfu 78 5 agent agent NN cord-006393-jcj9nqfu 78 6 , , , cord-006393-jcj9nqfu 78 7 mortality mortality NN cord-006393-jcj9nqfu 78 8 can can MD cord-006393-jcj9nqfu 78 9 range range VB cord-006393-jcj9nqfu 78 10 from from IN cord-006393-jcj9nqfu 78 11 85 85 CD cord-006393-jcj9nqfu 78 12 to to IN cord-006393-jcj9nqfu 78 13 as as RB cord-006393-jcj9nqfu 78 14 much much JJ cord-006393-jcj9nqfu 78 15 as as IN cord-006393-jcj9nqfu 78 16 100 100 CD cord-006393-jcj9nqfu 78 17 % % NN cord-006393-jcj9nqfu 78 18 . . . cord-006393-jcj9nqfu 79 1 There there EX cord-006393-jcj9nqfu 79 2 are be VBP cord-006393-jcj9nqfu 79 3 several several JJ cord-006393-jcj9nqfu 79 4 risk risk NN cord-006393-jcj9nqfu 79 5 factors factor NNS cord-006393-jcj9nqfu 79 6 for for IN cord-006393-jcj9nqfu 79 7 the the DT cord-006393-jcj9nqfu 79 8 development development NN cord-006393-jcj9nqfu 79 9 of of IN cord-006393-jcj9nqfu 79 10 interstitial interstitial JJ cord-006393-jcj9nqfu 79 11 pneumonia pneumonia NN cord-006393-jcj9nqfu 79 12 such such JJ cord-006393-jcj9nqfu 79 13 as as IN cord-006393-jcj9nqfu 79 14 TBI TBI NNP cord-006393-jcj9nqfu 79 15 ( ( -LRB- cord-006393-jcj9nqfu 79 16 if if IN cord-006393-jcj9nqfu 79 17 the the DT cord-006393-jcj9nqfu 79 18 lung lung NN cord-006393-jcj9nqfu 79 19 dose dose NN cord-006393-jcj9nqfu 79 20 exceeds exceed VBZ cord-006393-jcj9nqfu 79 21 600 600 CD cord-006393-jcj9nqfu 79 22 rads rad NNS cord-006393-jcj9nqfu 79 23 ) ) -RRB- cord-006393-jcj9nqfu 79 24 , , , cord-006393-jcj9nqfu 79 25 acute acute JJ cord-006393-jcj9nqfu 79 26 GVHD GVHD NNP cord-006393-jcj9nqfu 79 27 , , , cord-006393-jcj9nqfu 79 28 increased increase VBN cord-006393-jcj9nqfu 79 29 age age NN cord-006393-jcj9nqfu 79 30 of of IN cord-006393-jcj9nqfu 79 31 the the DT cord-006393-jcj9nqfu 79 32 patient patient NN cord-006393-jcj9nqfu 79 33 , , , cord-006393-jcj9nqfu 79 34 CMV CMV NNP cord-006393-jcj9nqfu 79 35 seropositivity seropositivity NN cord-006393-jcj9nqfu 79 36 of of IN cord-006393-jcj9nqfu 79 37 the the DT cord-006393-jcj9nqfu 79 38 patient patient NN cord-006393-jcj9nqfu 79 39 before before IN cord-006393-jcj9nqfu 79 40 the the DT cord-006393-jcj9nqfu 79 41 transplant transplant NN cord-006393-jcj9nqfu 79 42 , , , cord-006393-jcj9nqfu 79 43 transfusion transfusion NN cord-006393-jcj9nqfu 79 44 of of IN cord-006393-jcj9nqfu 79 45 blood blood NN cord-006393-jcj9nqfu 79 46 products product NNS cord-006393-jcj9nqfu 79 47 from from IN cord-006393-jcj9nqfu 79 48 CMV CMV NNP cord-006393-jcj9nqfu 79 49 - - HYPH cord-006393-jcj9nqfu 79 50 positive positive JJ cord-006393-jcj9nqfu 79 51 donors donor NNS cord-006393-jcj9nqfu 79 52 , , , cord-006393-jcj9nqfu 79 53 inability inability NN cord-006393-jcj9nqfu 79 54 to to TO cord-006393-jcj9nqfu 79 55 generate generate VB cord-006393-jcj9nqfu 79 56 an an DT cord-006393-jcj9nqfu 79 57 antiviral antiviral JJ cord-006393-jcj9nqfu 79 58 cytotoxicity cytotoxicity NN cord-006393-jcj9nqfu 79 59 ( ( -LRB- cord-006393-jcj9nqfu 79 60 which which WDT cord-006393-jcj9nqfu 79 61 is be VBZ cord-006393-jcj9nqfu 79 62 very very RB cord-006393-jcj9nqfu 79 63 common common JJ cord-006393-jcj9nqfu 79 64 in in IN cord-006393-jcj9nqfu 79 65 the the DT cord-006393-jcj9nqfu 79 66 postengraftment postengraftment NN cord-006393-jcj9nqfu 79 67 phase phase NN cord-006393-jcj9nqfu 79 68 ) ) -RRB- cord-006393-jcj9nqfu 79 69 , , , cord-006393-jcj9nqfu 79 70 and and CC cord-006393-jcj9nqfu 79 71 inability inability NN cord-006393-jcj9nqfu 79 72 to to TO cord-006393-jcj9nqfu 79 73 mount mount VB cord-006393-jcj9nqfu 79 74 a a DT cord-006393-jcj9nqfu 79 75 humoral humoral JJ cord-006393-jcj9nqfu 79 76 antibody antibody NN cord-006393-jcj9nqfu 79 77 response response NN cord-006393-jcj9nqfu 79 78 . . . cord-006393-jcj9nqfu 80 1 The the DT cord-006393-jcj9nqfu 80 2 latter latter JJ cord-006393-jcj9nqfu 80 3 defect defect NN cord-006393-jcj9nqfu 80 4 is be VBZ cord-006393-jcj9nqfu 80 5 quite quite RB cord-006393-jcj9nqfu 80 6 important important JJ cord-006393-jcj9nqfu 80 7 and and CC cord-006393-jcj9nqfu 80 8 suggests suggest VBZ cord-006393-jcj9nqfu 80 9 a a DT cord-006393-jcj9nqfu 80 10 potential potential JJ cord-006393-jcj9nqfu 80 11 rote rote NN cord-006393-jcj9nqfu 80 12 for for IN cord-006393-jcj9nqfu 80 13 passive passive JJ cord-006393-jcj9nqfu 80 14 therapy therapy NN cord-006393-jcj9nqfu 80 15 with with IN cord-006393-jcj9nqfu 80 16 antibodies antibody NNS cord-006393-jcj9nqfu 80 17 . . . cord-006393-jcj9nqfu 81 1 Historically historically RB cord-006393-jcj9nqfu 81 2 bone bone NN cord-006393-jcj9nqfu 81 3 marrow marrow NN cord-006393-jcj9nqfu 81 4 transplant transplant NN cord-006393-jcj9nqfu 81 5 recipients recipient NNS cord-006393-jcj9nqfu 81 6 who who WP cord-006393-jcj9nqfu 81 7 have have VBP cord-006393-jcj9nqfu 81 8 high high JJ cord-006393-jcj9nqfu 81 9 titers titer NNS cord-006393-jcj9nqfu 81 10 of of IN cord-006393-jcj9nqfu 81 11 complement complement NN cord-006393-jcj9nqfu 81 12 - - HYPH cord-006393-jcj9nqfu 81 13 fixing fix VBG cord-006393-jcj9nqfu 81 14 antibodies antibody NNS cord-006393-jcj9nqfu 81 15 to to IN cord-006393-jcj9nqfu 81 16 CMV CMV NNP cord-006393-jcj9nqfu 81 17 prior prior RB cord-006393-jcj9nqfu 81 18 to to IN cord-006393-jcj9nqfu 81 19 transplant transplant NN cord-006393-jcj9nqfu 81 20 have have VBP cord-006393-jcj9nqfu 81 21 had have VBN cord-006393-jcj9nqfu 81 22 a a DT cord-006393-jcj9nqfu 81 23 better well JJR cord-006393-jcj9nqfu 81 24 prognosis prognosis NN cord-006393-jcj9nqfu 81 25 for for IN cord-006393-jcj9nqfu 81 26 overcoming overcome VBG cord-006393-jcj9nqfu 81 27 such such PDT cord-006393-jcj9nqfu 81 28 a a DT cord-006393-jcj9nqfu 81 29 severe severe JJ cord-006393-jcj9nqfu 81 30 viral viral JJ cord-006393-jcj9nqfu 81 31 pneumonia pneumonia NN cord-006393-jcj9nqfu 81 32 . . . cord-006393-jcj9nqfu 82 1 In in IN cord-006393-jcj9nqfu 82 2 the the DT cord-006393-jcj9nqfu 82 3 murine murine JJ cord-006393-jcj9nqfu 82 4 model model NN cord-006393-jcj9nqfu 82 5 , , , cord-006393-jcj9nqfu 82 6 it -PRON- PRP cord-006393-jcj9nqfu 82 7 could could MD cord-006393-jcj9nqfu 82 8 be be VB cord-006393-jcj9nqfu 82 9 shown show VBN cord-006393-jcj9nqfu 82 10 that that IN cord-006393-jcj9nqfu 82 11 passive passive JJ cord-006393-jcj9nqfu 82 12 immunization immunization NN cord-006393-jcj9nqfu 82 13 can can MD cord-006393-jcj9nqfu 82 14 modify modify VB cord-006393-jcj9nqfu 82 15 CMV CMV NNP cord-006393-jcj9nqfu 82 16 infection infection NN cord-006393-jcj9nqfu 82 17 . . . cord-006393-jcj9nqfu 83 1 Several several JJ cord-006393-jcj9nqfu 83 2 studies study NNS cord-006393-jcj9nqfu 83 3 have have VBP cord-006393-jcj9nqfu 83 4 been be VBN cord-006393-jcj9nqfu 83 5 carried carry VBN cord-006393-jcj9nqfu 83 6 out out RP cord-006393-jcj9nqfu 83 7 to to TO cord-006393-jcj9nqfu 83 8 see see VB cord-006393-jcj9nqfu 83 9 if if IN cord-006393-jcj9nqfu 83 10 passive passive JJ cord-006393-jcj9nqfu 83 11 immunization immunization NN cord-006393-jcj9nqfu 83 12 with with IN cord-006393-jcj9nqfu 83 13 antibodies antibody NNS cord-006393-jcj9nqfu 83 14 against against IN cord-006393-jcj9nqfu 83 15 CMV CMV NNP cord-006393-jcj9nqfu 83 16 would would MD cord-006393-jcj9nqfu 83 17 prevent prevent VB cord-006393-jcj9nqfu 83 18 interstitial interstitial JJ cord-006393-jcj9nqfu 83 19 pneumonia pneumonia NN cord-006393-jcj9nqfu 83 20 . . . cord-006393-jcj9nqfu 84 1 Investigators investigator NNS cord-006393-jcj9nqfu 84 2 from from IN cord-006393-jcj9nqfu 84 3 UCLA UCLA NNP cord-006393-jcj9nqfu 84 4 , , , cord-006393-jcj9nqfu 84 5 Minnesota Minnesota NNP cord-006393-jcj9nqfu 84 6 , , , cord-006393-jcj9nqfu 84 7 and and CC cord-006393-jcj9nqfu 84 8 Sloan Sloan NNP cord-006393-jcj9nqfu 84 9 - - HYPH cord-006393-jcj9nqfu 84 10 Kettering Kettering NNP cord-006393-jcj9nqfu 84 11 all all DT cord-006393-jcj9nqfu 84 12 showed show VBD cord-006393-jcj9nqfu 84 13 , , , cord-006393-jcj9nqfu 84 14 in in IN cord-006393-jcj9nqfu 84 15 reasonably reasonably RB cord-006393-jcj9nqfu 84 16 well well RB cord-006393-jcj9nqfu 84 17 - - HYPH cord-006393-jcj9nqfu 84 18 controlled control VBN cord-006393-jcj9nqfu 84 19 studies study NNS cord-006393-jcj9nqfu 84 20 , , , cord-006393-jcj9nqfu 84 21 that that IN cord-006393-jcj9nqfu 84 22 the the DT cord-006393-jcj9nqfu 84 23 incidence incidence NN cord-006393-jcj9nqfu 84 24 of of IN cord-006393-jcj9nqfu 84 25 CMV CMV NNP cord-006393-jcj9nqfu 84 26 interstitial interstitial JJ cord-006393-jcj9nqfu 84 27 pneumonia pneumonia NN cord-006393-jcj9nqfu 84 28 was be VBD cord-006393-jcj9nqfu 84 29 reduced reduce VBN cord-006393-jcj9nqfu 84 30 in in IN cord-006393-jcj9nqfu 84 31 patients patient NNS cord-006393-jcj9nqfu 84 32 given give VBN cord-006393-jcj9nqfu 84 33 high high JJ cord-006393-jcj9nqfu 84 34 - - HYPH cord-006393-jcj9nqfu 84 35 titered titered JJ cord-006393-jcj9nqfu 84 36 antibody antibody NN cord-006393-jcj9nqfu 84 37 preparations preparation NNS cord-006393-jcj9nqfu 84 38 compared compare VBN cord-006393-jcj9nqfu 84 39 to to IN cord-006393-jcj9nqfu 84 40 that that DT cord-006393-jcj9nqfu 84 41 in in IN cord-006393-jcj9nqfu 84 42 the the DT cord-006393-jcj9nqfu 84 43 control control NN cord-006393-jcj9nqfu 84 44 group group NN cord-006393-jcj9nqfu 84 45 . . . cord-006393-jcj9nqfu 85 1 This this DT cord-006393-jcj9nqfu 85 2 finding finding NN cord-006393-jcj9nqfu 85 3 triggered trigger VBD cord-006393-jcj9nqfu 85 4 numerous numerous JJ cord-006393-jcj9nqfu 85 5 other other JJ cord-006393-jcj9nqfu 85 6 studies study NNS cord-006393-jcj9nqfu 85 7 , , , cord-006393-jcj9nqfu 85 8 mostly mostly RB cord-006393-jcj9nqfu 85 9 uncontrolled uncontrolled JJ cord-006393-jcj9nqfu 85 10 , , , cord-006393-jcj9nqfu 85 11 which which WDT cord-006393-jcj9nqfu 85 12 can can MD cord-006393-jcj9nqfu 85 13 be be VB cord-006393-jcj9nqfu 85 14 summarized summarize VBN cord-006393-jcj9nqfu 85 15 as as IN cord-006393-jcj9nqfu 85 16 follows follow VBZ cord-006393-jcj9nqfu 85 17 . . . cord-006393-jcj9nqfu 86 1 IVIG IVIG NNP cord-006393-jcj9nqfu 86 2 is be VBZ cord-006393-jcj9nqfu 86 3 effective effective JJ cord-006393-jcj9nqfu 86 4 in in IN cord-006393-jcj9nqfu 86 5 preventing prevent VBG cord-006393-jcj9nqfu 86 6 CMV CMV NNP cord-006393-jcj9nqfu 86 7 infections infection NNS cord-006393-jcj9nqfu 86 8 in in IN cord-006393-jcj9nqfu 86 9 CMV CMV NNP cord-006393-jcj9nqfu 86 10 - - HYPH cord-006393-jcj9nqfu 86 11 seronegative seronegative JJ cord-006393-jcj9nqfu 86 12 recipients recipient NNS cord-006393-jcj9nqfu 86 13 who who WP cord-006393-jcj9nqfu 86 14 receive receive VBP cord-006393-jcj9nqfu 86 15 CMVseronegative cmvseronegative JJ cord-006393-jcj9nqfu 86 16 grafts graft NNS cord-006393-jcj9nqfu 86 17 . . . cord-006393-jcj9nqfu 87 1 It -PRON- PRP cord-006393-jcj9nqfu 87 2 is be VBZ cord-006393-jcj9nqfu 87 3 likely likely JJ cord-006393-jcj9nqfu 87 4 to to TO cord-006393-jcj9nqfu 87 5 be be VB cord-006393-jcj9nqfu 87 6 ineffective ineffective JJ cord-006393-jcj9nqfu 87 7 in in IN cord-006393-jcj9nqfu 87 8 preventing prevent VBG cord-006393-jcj9nqfu 87 9 the the DT cord-006393-jcj9nqfu 87 10 development development NN cord-006393-jcj9nqfu 87 11 of of IN cord-006393-jcj9nqfu 87 12 interstitial interstitial JJ cord-006393-jcj9nqfu 87 13 pneumonia pneumonia NN cord-006393-jcj9nqfu 87 14 in in IN cord-006393-jcj9nqfu 87 15 seronegative seronegative JJ cord-006393-jcj9nqfu 87 16 recipients recipient NNS cord-006393-jcj9nqfu 87 17 who who WP cord-006393-jcj9nqfu 87 18 receive receive VBP cord-006393-jcj9nqfu 87 19 seropositive seropositive JJ cord-006393-jcj9nqfu 87 20 grafts graft NNS cord-006393-jcj9nqfu 87 21 . . . cord-006393-jcj9nqfu 88 1 Furthermore furthermore RB cord-006393-jcj9nqfu 88 2 , , , cord-006393-jcj9nqfu 88 3 it -PRON- PRP cord-006393-jcj9nqfu 88 4 is be VBZ cord-006393-jcj9nqfu 88 5 likely likely JJ cord-006393-jcj9nqfu 88 6 to to TO cord-006393-jcj9nqfu 88 7 be be VB cord-006393-jcj9nqfu 88 8 ineffective ineffective JJ cord-006393-jcj9nqfu 88 9 in in IN cord-006393-jcj9nqfu 88 10 CMV CMV NNP cord-006393-jcj9nqfu 88 11 - - HYPH cord-006393-jcj9nqfu 88 12 seronegative seronegative JJ cord-006393-jcj9nqfu 88 13 recipients recipient NNS cord-006393-jcj9nqfu 88 14 who who WP cord-006393-jcj9nqfu 88 15 receive receive VBP cord-006393-jcj9nqfu 88 16 CMV CMV NNP cord-006393-jcj9nqfu 88 17 - - HYPH cord-006393-jcj9nqfu 88 18 seropositive seropositive JJ cord-006393-jcj9nqfu 88 19 blood blood NN cord-006393-jcj9nqfu 88 20 products product NNS cord-006393-jcj9nqfu 88 21 ; ; : cord-006393-jcj9nqfu 88 22 however however RB cord-006393-jcj9nqfu 88 23 , , , cord-006393-jcj9nqfu 88 24 the the DT cord-006393-jcj9nqfu 88 25 latter latter JJ cord-006393-jcj9nqfu 88 26 statement statement NN cord-006393-jcj9nqfu 88 27 is be VBZ cord-006393-jcj9nqfu 88 28 not not RB cord-006393-jcj9nqfu 88 29 fully fully RB cord-006393-jcj9nqfu 88 30 substantiated substantiate VBN cord-006393-jcj9nqfu 88 31 and and CC cord-006393-jcj9nqfu 88 32 a a DT cord-006393-jcj9nqfu 88 33 number number NN cord-006393-jcj9nqfu 88 34 of of IN cord-006393-jcj9nqfu 88 35 studies study NNS cord-006393-jcj9nqfu 88 36 are be VBP cord-006393-jcj9nqfu 88 37 in in IN cord-006393-jcj9nqfu 88 38 progress progress NN cord-006393-jcj9nqfu 88 39 to to TO cord-006393-jcj9nqfu 88 40 delineate delineate VB cord-006393-jcj9nqfu 88 41 that that DT cord-006393-jcj9nqfu 88 42 point point NN cord-006393-jcj9nqfu 88 43 . . . cord-006393-jcj9nqfu 89 1 It -PRON- PRP cord-006393-jcj9nqfu 89 2 is be VBZ cord-006393-jcj9nqfu 89 3 likely likely JJ cord-006393-jcj9nqfu 89 4 that that IN cord-006393-jcj9nqfu 89 5 immunoglobulin immunoglobulin NN cord-006393-jcj9nqfu 89 6 is be VBZ cord-006393-jcj9nqfu 89 7 ineffective ineffective JJ cord-006393-jcj9nqfu 89 8 in in IN cord-006393-jcj9nqfu 89 9 CMV CMV NNP cord-006393-jcj9nqfu 89 10 - - HYPH cord-006393-jcj9nqfu 89 11 seropositive seropositive JJ cord-006393-jcj9nqfu 89 12 recipients recipient NNS cord-006393-jcj9nqfu 89 13 who who WP cord-006393-jcj9nqfu 89 14 receive receive VBP cord-006393-jcj9nqfu 89 15 either either CC cord-006393-jcj9nqfu 89 16 CMV CMV NNP cord-006393-jcj9nqfu 89 17 - - HYPH cord-006393-jcj9nqfu 89 18 seropositive seropositive JJ cord-006393-jcj9nqfu 89 19 or or CC cord-006393-jcj9nqfu 89 20 CMV CMV NNP cord-006393-jcj9nqfu 89 21 - - HYPH cord-006393-jcj9nqfu 89 22 seronegative seronegative JJ cord-006393-jcj9nqfu 89 23 blood blood NN cord-006393-jcj9nqfu 89 24 products product NNS cord-006393-jcj9nqfu 89 25 . . . cord-006393-jcj9nqfu 90 1 We -PRON- PRP cord-006393-jcj9nqfu 90 2 conducted conduct VBD cord-006393-jcj9nqfu 90 3 our -PRON- PRP$ cord-006393-jcj9nqfu 90 4 own own JJ cord-006393-jcj9nqfu 90 5 trial trial NN cord-006393-jcj9nqfu 90 6 with with IN cord-006393-jcj9nqfu 90 7 IVIG IVIG NNP cord-006393-jcj9nqfu 90 8 in in IN cord-006393-jcj9nqfu 90 9 which which WDT cord-006393-jcj9nqfu 90 10 119 119 CD cord-006393-jcj9nqfu 90 11 patients patient NNS cord-006393-jcj9nqfu 90 12 were be VBD cord-006393-jcj9nqfu 90 13 enrolled enrol VBN cord-006393-jcj9nqfu 90 14 ( ( -LRB- cord-006393-jcj9nqfu 90 15 7 7 CD cord-006393-jcj9nqfu 90 16 ) ) -RRB- cord-006393-jcj9nqfu 90 17 . . . cord-006393-jcj9nqfu 91 1 Slightly slightly RB cord-006393-jcj9nqfu 91 2 more more JJR cord-006393-jcj9nqfu 91 3 than than IN cord-006393-jcj9nqfu 91 4 half half NN cord-006393-jcj9nqfu 91 5 of of IN cord-006393-jcj9nqfu 91 6 the the DT cord-006393-jcj9nqfu 91 7 patients patient NNS cord-006393-jcj9nqfu 91 8 were be VBD cord-006393-jcj9nqfu 91 9 CMV CMV NNP cord-006393-jcj9nqfu 91 10 seronegative seronegative JJ cord-006393-jcj9nqfu 91 11 . . . cord-006393-jcj9nqfu 92 1 The the DT cord-006393-jcj9nqfu 92 2 median median JJ cord-006393-jcj9nqfu 92 3 observation observation NN cord-006393-jcj9nqfu 92 4 time time NN cord-006393-jcj9nqfu 92 5 was be VBD cord-006393-jcj9nqfu 92 6 29 29 CD cord-006393-jcj9nqfu 92 7 months month NNS cord-006393-jcj9nqfu 92 8 . . . cord-006393-jcj9nqfu 93 1 All all PDT cord-006393-jcj9nqfu 93 2 the the DT cord-006393-jcj9nqfu 93 3 patients patient NNS cord-006393-jcj9nqfu 93 4 received receive VBD cord-006393-jcj9nqfu 93 5 CMV CMV NNP cord-006393-jcj9nqfu 93 6 - - HYPH cord-006393-jcj9nqfu 93 7 negative negative JJ cord-006393-jcj9nqfu 93 8 blood blood NN cord-006393-jcj9nqfu 93 9 products product NNS cord-006393-jcj9nqfu 93 10 and and CC cord-006393-jcj9nqfu 93 11 were be VBD cord-006393-jcj9nqfu 93 12 given give VBN cord-006393-jcj9nqfu 93 13 500 500 CD cord-006393-jcj9nqfu 93 14 mg mg NNP cord-006393-jcj9nqfu 93 15 / / SYM cord-006393-jcj9nqfu 93 16 kg kg NNS cord-006393-jcj9nqfu 93 17 of of IN cord-006393-jcj9nqfu 93 18 IVIG IVIG NNP cord-006393-jcj9nqfu 93 19 every every DT cord-006393-jcj9nqfu 93 20 2 2 CD cord-006393-jcj9nqfu 93 21 weeks week NNS cord-006393-jcj9nqfu 93 22 for for IN cord-006393-jcj9nqfu 93 23 eight eight CD cord-006393-jcj9nqfu 93 24 administrations administration NNS cord-006393-jcj9nqfu 93 25 . . . cord-006393-jcj9nqfu 94 1 There there EX cord-006393-jcj9nqfu 94 2 were be VBD cord-006393-jcj9nqfu 94 3 no no DT cord-006393-jcj9nqfu 94 4 CMV CMV NNP cord-006393-jcj9nqfu 94 5 infections infection NNS cord-006393-jcj9nqfu 94 6 and and CC cord-006393-jcj9nqfu 94 7 there there EX cord-006393-jcj9nqfu 94 8 was be VBD cord-006393-jcj9nqfu 94 9 no no DT cord-006393-jcj9nqfu 94 10 CMV CMV NNP cord-006393-jcj9nqfu 94 11 pneumonia pneumonia NN cord-006393-jcj9nqfu 94 12 in in IN cord-006393-jcj9nqfu 94 13 the the DT cord-006393-jcj9nqfu 94 14 first first JJ cord-006393-jcj9nqfu 94 15 group group NN cord-006393-jcj9nqfu 94 16 of of IN cord-006393-jcj9nqfu 94 17 57 57 CD cord-006393-jcj9nqfu 94 18 patients patient NNS cord-006393-jcj9nqfu 94 19 , , , cord-006393-jcj9nqfu 94 20 who who WP cord-006393-jcj9nqfu 94 21 were be VBD cord-006393-jcj9nqfu 94 22 CMV CMV NNP cord-006393-jcj9nqfu 94 23 seronegative seronegative JJ cord-006393-jcj9nqfu 94 24 and and CC cord-006393-jcj9nqfu 94 25 had have VBD cord-006393-jcj9nqfu 94 26 received receive VBN cord-006393-jcj9nqfu 94 27 a a DT cord-006393-jcj9nqfu 94 28 graft graft NN cord-006393-jcj9nqfu 94 29 from from IN cord-006393-jcj9nqfu 94 30 a a DT cord-006393-jcj9nqfu 94 31 CMVseronegative cmvseronegative JJ cord-006393-jcj9nqfu 94 32 donor donor NN cord-006393-jcj9nqfu 94 33 . . . cord-006393-jcj9nqfu 95 1 In in IN cord-006393-jcj9nqfu 95 2 the the DT cord-006393-jcj9nqfu 95 3 next next JJ cord-006393-jcj9nqfu 95 4 group group NN cord-006393-jcj9nqfu 95 5 of of IN cord-006393-jcj9nqfu 95 6 CMVseronegative CMVseronegative NNP cord-006393-jcj9nqfu 95 7 recipients recipient NNS cord-006393-jcj9nqfu 95 8 , , , cord-006393-jcj9nqfu 95 9 who who WP cord-006393-jcj9nqfu 95 10 were be VBD cord-006393-jcj9nqfu 95 11 given give VBN cord-006393-jcj9nqfu 95 12 a a DT cord-006393-jcj9nqfu 95 13 graft graft NN cord-006393-jcj9nqfu 95 14 from from IN cord-006393-jcj9nqfu 95 15 a a DT cord-006393-jcj9nqfu 95 16 CMV CMV NNP cord-006393-jcj9nqfu 95 17 - - HYPH cord-006393-jcj9nqfu 95 18 seropositive seropositive JJ cord-006393-jcj9nqfu 95 19 donor donor NN cord-006393-jcj9nqfu 95 20 , , , cord-006393-jcj9nqfu 95 21 3 3 CD cord-006393-jcj9nqfu 95 22 of of IN cord-006393-jcj9nqfu 95 23 12 12 CD cord-006393-jcj9nqfu 95 24 patients patient NNS cord-006393-jcj9nqfu 95 25 developed develop VBN cord-006393-jcj9nqfu 95 26 viremia viremia NN cord-006393-jcj9nqfu 95 27 or or CC cord-006393-jcj9nqfu 95 28 viruria viruria NN cord-006393-jcj9nqfu 95 29 but but CC cord-006393-jcj9nqfu 95 30 none none NN cord-006393-jcj9nqfu 95 31 of of IN cord-006393-jcj9nqfu 95 32 them -PRON- PRP cord-006393-jcj9nqfu 95 33 developed develop VBD cord-006393-jcj9nqfu 95 34 pneumonia pneumonia NN cord-006393-jcj9nqfu 95 35 . . . cord-006393-jcj9nqfu 96 1 The the DT cord-006393-jcj9nqfu 96 2 low low JJ cord-006393-jcj9nqfu 96 3 incidence incidence NN cord-006393-jcj9nqfu 96 4 of of IN cord-006393-jcj9nqfu 96 5 CMV CMV NNP cord-006393-jcj9nqfu 96 6 interstitial interstitial JJ cord-006393-jcj9nqfu 96 7 pneumonia pneumonia NN cord-006393-jcj9nqfu 96 8 in in IN cord-006393-jcj9nqfu 96 9 this this DT cord-006393-jcj9nqfu 96 10 group group NN cord-006393-jcj9nqfu 96 11 indicated indicate VBD cord-006393-jcj9nqfu 96 12 that that IN cord-006393-jcj9nqfu 96 13 IVIG IVIG NNP cord-006393-jcj9nqfu 96 14 might may MD cord-006393-jcj9nqfu 96 15 be be VB cord-006393-jcj9nqfu 96 16 effective effective JJ cord-006393-jcj9nqfu 96 17 in in IN cord-006393-jcj9nqfu 96 18 the the DT cord-006393-jcj9nqfu 96 19 CMV CMV NNP cord-006393-jcj9nqfu 96 20 - - HYPH cord-006393-jcj9nqfu 96 21 seronegative seronegative JJ cord-006393-jcj9nqfu 96 22 patient patient NN cord-006393-jcj9nqfu 96 23 even even RB cord-006393-jcj9nqfu 96 24 when when WRB cord-006393-jcj9nqfu 96 25 receiving receive VBG cord-006393-jcj9nqfu 96 26 a a DT cord-006393-jcj9nqfu 96 27 seropositive seropositive JJ cord-006393-jcj9nqfu 96 28 donor donor NN cord-006393-jcj9nqfu 96 29 graft graft NN cord-006393-jcj9nqfu 96 30 . . . cord-006393-jcj9nqfu 97 1 Unfortunately unfortunately RB cord-006393-jcj9nqfu 97 2 , , , cord-006393-jcj9nqfu 97 3 IVIG IVIG NNP cord-006393-jcj9nqfu 97 4 was be VBD cord-006393-jcj9nqfu 97 5 largely largely RB cord-006393-jcj9nqfu 97 6 ineffective ineffective JJ cord-006393-jcj9nqfu 97 7 in in IN cord-006393-jcj9nqfu 97 8 seropositive seropositive JJ cord-006393-jcj9nqfu 97 9 patients patient NNS cord-006393-jcj9nqfu 97 10 . . . cord-006393-jcj9nqfu 98 1 Of of IN cord-006393-jcj9nqfu 98 2 the the DT cord-006393-jcj9nqfu 98 3 50 50 CD cord-006393-jcj9nqfu 98 4 seropositive seropositive JJ cord-006393-jcj9nqfu 98 5 recipients recipient NNS cord-006393-jcj9nqfu 98 6 , , , cord-006393-jcj9nqfu 98 7 33 33 CD cord-006393-jcj9nqfu 98 8 ( ( -LRB- cord-006393-jcj9nqfu 98 9 66 66 CD cord-006393-jcj9nqfu 98 10 % % NN cord-006393-jcj9nqfu 98 11 ) ) -RRB- cord-006393-jcj9nqfu 98 12 developed develop VBD cord-006393-jcj9nqfu 98 13 a a DT cord-006393-jcj9nqfu 98 14 positive positive JJ cord-006393-jcj9nqfu 98 15 CMV CMV NNP cord-006393-jcj9nqfu 98 16 culture culture NN cord-006393-jcj9nqfu 98 17 and and CC cord-006393-jcj9nqfu 98 18 8 8 CD cord-006393-jcj9nqfu 98 19 developed develop VBD cord-006393-jcj9nqfu 98 20 CMV CMV NNP cord-006393-jcj9nqfu 98 21 pneumonia pneumonia NN cord-006393-jcj9nqfu 98 22 , , , cord-006393-jcj9nqfu 98 23 which which WDT cord-006393-jcj9nqfu 98 24 was be VBD cord-006393-jcj9nqfu 98 25 fatal fatal JJ cord-006393-jcj9nqfu 98 26 in in IN cord-006393-jcj9nqfu 98 27 6 6 CD cord-006393-jcj9nqfu 98 28 cases case NNS cord-006393-jcj9nqfu 98 29 . . . cord-006393-jcj9nqfu 99 1 When when WRB cord-006393-jcj9nqfu 99 2 all all DT cord-006393-jcj9nqfu 99 3 groups group NNS cord-006393-jcj9nqfu 99 4 are be VBP cord-006393-jcj9nqfu 99 5 combined combine VBN cord-006393-jcj9nqfu 99 6 the the DT cord-006393-jcj9nqfu 99 7 overall overall JJ cord-006393-jcj9nqfu 99 8 effect effect NN cord-006393-jcj9nqfu 99 9 of of IN cord-006393-jcj9nqfu 99 10 IVIG IVIG NNP cord-006393-jcj9nqfu 99 11 appears appear VBZ cord-006393-jcj9nqfu 99 12 impressive impressive JJ cord-006393-jcj9nqfu 99 13 : : : cord-006393-jcj9nqfu 99 14 a a DT cord-006393-jcj9nqfu 99 15 13 13 CD cord-006393-jcj9nqfu 99 16 % % NN cord-006393-jcj9nqfu 99 17 incidence incidence NN cord-006393-jcj9nqfu 99 18 of of IN cord-006393-jcj9nqfu 99 19 CMV CMV NNP cord-006393-jcj9nqfu 99 20 infection infection NN cord-006393-jcj9nqfu 99 21 and and CC cord-006393-jcj9nqfu 99 22 a a DT cord-006393-jcj9nqfu 99 23 7 7 CD cord-006393-jcj9nqfu 99 24 % % NN cord-006393-jcj9nqfu 99 25 incidence incidence NN cord-006393-jcj9nqfu 99 26 of of IN cord-006393-jcj9nqfu 99 27 CMV CMV NNP cord-006393-jcj9nqfu 99 28 pneumonia pneumonia NN cord-006393-jcj9nqfu 99 29 , , , cord-006393-jcj9nqfu 99 30 suggesting suggest VBG cord-006393-jcj9nqfu 99 31 that that IN cord-006393-jcj9nqfu 99 32 IVIG IVIG NNP cord-006393-jcj9nqfu 99 33 was be VBD cord-006393-jcj9nqfu 99 34 able able JJ cord-006393-jcj9nqfu 99 35 to to TO cord-006393-jcj9nqfu 99 36 reduce reduce VB cord-006393-jcj9nqfu 99 37 the the DT cord-006393-jcj9nqfu 99 38 incidence incidence NN cord-006393-jcj9nqfu 99 39 of of IN cord-006393-jcj9nqfu 99 40 CMV CMV NNP cord-006393-jcj9nqfu 99 41 pneumonia pneumonia NN cord-006393-jcj9nqfu 99 42 , , , cord-006393-jcj9nqfu 99 43 perhaps perhaps RB cord-006393-jcj9nqfu 99 44 even even RB cord-006393-jcj9nqfu 99 45 in in IN cord-006393-jcj9nqfu 99 46 CMV CMV NNP cord-006393-jcj9nqfu 99 47 - - HYPH cord-006393-jcj9nqfu 99 48 seropositive seropositive JJ cord-006393-jcj9nqfu 99 49 patients patient NNS cord-006393-jcj9nqfu 99 50 . . . cord-006393-jcj9nqfu 100 1 We -PRON- PRP cord-006393-jcj9nqfu 100 2 tried try VBD cord-006393-jcj9nqfu 100 3 to to TO cord-006393-jcj9nqfu 100 4 obtain obtain VB cord-006393-jcj9nqfu 100 5 more more RBR cord-006393-jcj9nqfu 100 6 definitive definitive JJ cord-006393-jcj9nqfu 100 7 information information NN cord-006393-jcj9nqfu 100 8 about about IN cord-006393-jcj9nqfu 100 9 the the DT cord-006393-jcj9nqfu 100 10 role role NN cord-006393-jcj9nqfu 100 11 of of IN cord-006393-jcj9nqfu 100 12 IVIG IVIG NNP cord-006393-jcj9nqfu 100 13 in in IN cord-006393-jcj9nqfu 100 14 seropositive seropositive JJ cord-006393-jcj9nqfu 100 15 recipients recipient NNS cord-006393-jcj9nqfu 100 16 . . . cord-006393-jcj9nqfu 101 1 We -PRON- PRP cord-006393-jcj9nqfu 101 2 were be VBD cord-006393-jcj9nqfu 101 3 unwilling unwilling JJ cord-006393-jcj9nqfu 101 4 to to TO cord-006393-jcj9nqfu 101 5 do do VB cord-006393-jcj9nqfu 101 6 a a DT cord-006393-jcj9nqfu 101 7 randomized randomized JJ cord-006393-jcj9nqfu 101 8 , , , cord-006393-jcj9nqfu 101 9 placebocontrolled placebocontrolled JJ cord-006393-jcj9nqfu 101 10 study study NN cord-006393-jcj9nqfu 101 11 since since IN cord-006393-jcj9nqfu 101 12 we -PRON- PRP cord-006393-jcj9nqfu 101 13 had have VBD cord-006393-jcj9nqfu 101 14 ethical ethical JJ cord-006393-jcj9nqfu 101 15 problems problem NNS cord-006393-jcj9nqfu 101 16 with with IN cord-006393-jcj9nqfu 101 17 not not RB cord-006393-jcj9nqfu 101 18 treating treat VBG cord-006393-jcj9nqfu 101 19 all all PDT cord-006393-jcj9nqfu 101 20 our -PRON- PRP$ cord-006393-jcj9nqfu 101 21 patients patient NNS cord-006393-jcj9nqfu 101 22 with with IN cord-006393-jcj9nqfu 101 23 IVIG IVIG NNP cord-006393-jcj9nqfu 101 24 . . . cord-006393-jcj9nqfu 102 1 We -PRON- PRP cord-006393-jcj9nqfu 102 2 speculated speculate VBD cord-006393-jcj9nqfu 102 3 that that IN cord-006393-jcj9nqfu 102 4 if if IN cord-006393-jcj9nqfu 102 5 we -PRON- PRP cord-006393-jcj9nqfu 102 6 were be VBD cord-006393-jcj9nqfu 102 7 to to TO cord-006393-jcj9nqfu 102 8 give give VB cord-006393-jcj9nqfu 102 9 IVIG IVIG NNP cord-006393-jcj9nqfu 102 10 to to IN cord-006393-jcj9nqfu 102 11 seropositive seropositive JJ cord-006393-jcj9nqfu 102 12 patients patient NNS cord-006393-jcj9nqfu 102 13 in in IN cord-006393-jcj9nqfu 102 14 higher high JJR cord-006393-jcj9nqfu 102 15 doses dose NNS cord-006393-jcj9nqfu 102 16 and and CC cord-006393-jcj9nqfu 102 17 more more RBR cord-006393-jcj9nqfu 102 18 frequently frequently RB cord-006393-jcj9nqfu 102 19 , , , cord-006393-jcj9nqfu 102 20 we -PRON- PRP cord-006393-jcj9nqfu 102 21 might may MD cord-006393-jcj9nqfu 102 22 prevent prevent VB cord-006393-jcj9nqfu 102 23 not not RB cord-006393-jcj9nqfu 102 24 only only RB cord-006393-jcj9nqfu 102 25 CMV CMV NNP cord-006393-jcj9nqfu 102 26 excretion excretion NN cord-006393-jcj9nqfu 102 27 ( ( -LRB- cord-006393-jcj9nqfu 102 28 such such JJ cord-006393-jcj9nqfu 102 29 as as IN cord-006393-jcj9nqfu 102 30 viremia viremia NN cord-006393-jcj9nqfu 102 31 or or CC cord-006393-jcj9nqfu 102 32 viruria viruria NNP cord-006393-jcj9nqfu 102 33 ) ) -RRB- cord-006393-jcj9nqfu 102 34 but but CC cord-006393-jcj9nqfu 102 35 also also RB cord-006393-jcj9nqfu 102 36 the the DT cord-006393-jcj9nqfu 102 37 development development NN cord-006393-jcj9nqfu 102 38 of of IN cord-006393-jcj9nqfu 102 39 CMV CMV NNP cord-006393-jcj9nqfu 102 40 infection infection NN cord-006393-jcj9nqfu 102 41 . . . cord-006393-jcj9nqfu 103 1 For for IN cord-006393-jcj9nqfu 103 2 these these DT cord-006393-jcj9nqfu 103 3 reasons reason NNS cord-006393-jcj9nqfu 103 4 we -PRON- PRP cord-006393-jcj9nqfu 103 5 limited limit VBD cord-006393-jcj9nqfu 103 6 our -PRON- PRP$ cord-006393-jcj9nqfu 103 7 study study NN cord-006393-jcj9nqfu 103 8 to to IN cord-006393-jcj9nqfu 103 9 CMV CMV NNP cord-006393-jcj9nqfu 103 10 - - HYPH cord-006393-jcj9nqfu 103 11 seropositive seropositive JJ cord-006393-jcj9nqfu 103 12 recipients recipient NNS cord-006393-jcj9nqfu 103 13 and and CC cord-006393-jcj9nqfu 103 14 stratified stratify VBD cord-006393-jcj9nqfu 103 15 them -PRON- PRP cord-006393-jcj9nqfu 103 16 between between IN cord-006393-jcj9nqfu 103 17 two two CD cord-006393-jcj9nqfu 103 18 IVIG IVIG NNP cord-006393-jcj9nqfu 103 19 schedules schedule NNS cord-006393-jcj9nqfu 103 20 , , , cord-006393-jcj9nqfu 103 21 giving give VBG cord-006393-jcj9nqfu 103 22 either either CC cord-006393-jcj9nqfu 103 23 500 500 CD cord-006393-jcj9nqfu 103 24 mg mg NN cord-006393-jcj9nqfu 103 25 / / SYM cord-006393-jcj9nqfu 103 26 kg kg NN cord-006393-jcj9nqfu 103 27 every every DT cord-006393-jcj9nqfu 103 28 2 2 CD cord-006393-jcj9nqfu 103 29 weeks week NNS cord-006393-jcj9nqfu 103 30 for for IN cord-006393-jcj9nqfu 103 31 4 4 CD cord-006393-jcj9nqfu 103 32 months month NNS cord-006393-jcj9nqfu 103 33 or or CC cord-006393-jcj9nqfu 103 34 500 500 CD cord-006393-jcj9nqfu 103 35 mg mg NNP cord-006393-jcj9nqfu 103 36 / / SYM cord-006393-jcj9nqfu 103 37 kg kg NN cord-006393-jcj9nqfu 103 38 every every DT cord-006393-jcj9nqfu 103 39 week week NN cord-006393-jcj9nqfu 103 40 for for IN cord-006393-jcj9nqfu 103 41 4 4 CD cord-006393-jcj9nqfu 103 42 months month NNS cord-006393-jcj9nqfu 103 43 . . . cord-006393-jcj9nqfu 104 1 If if IN cord-006393-jcj9nqfu 104 2 patients patient NNS cord-006393-jcj9nqfu 104 3 became become VBD cord-006393-jcj9nqfu 104 4 excretors excretor NNS cord-006393-jcj9nqfu 104 5 of of IN cord-006393-jcj9nqfu 104 6 the the DT cord-006393-jcj9nqfu 104 7 virus virus NN cord-006393-jcj9nqfu 104 8 , , , cord-006393-jcj9nqfu 104 9 they -PRON- PRP cord-006393-jcj9nqfu 104 10 received receive VBD cord-006393-jcj9nqfu 104 11 a a DT cord-006393-jcj9nqfu 104 12 dose dose NN cord-006393-jcj9nqfu 104 13 of of IN cord-006393-jcj9nqfu 104 14 500 500 CD cord-006393-jcj9nqfu 104 15 mg mg NNP cord-006393-jcj9nqfu 104 16 / / SYM cord-006393-jcj9nqfu 104 17 kg kg NNP cord-006393-jcj9nqfu 104 18 daily daily RB cord-006393-jcj9nqfu 104 19 for for IN cord-006393-jcj9nqfu 104 20 10 10 CD cord-006393-jcj9nqfu 104 21 days day NNS cord-006393-jcj9nqfu 104 22 . . . cord-006393-jcj9nqfu 105 1 There there EX cord-006393-jcj9nqfu 105 2 were be VBD cord-006393-jcj9nqfu 105 3 24 24 CD cord-006393-jcj9nqfu 105 4 patients patient NNS cord-006393-jcj9nqfu 105 5 in in IN cord-006393-jcj9nqfu 105 6 the the DT cord-006393-jcj9nqfu 105 7 standard standard JJ cord-006393-jcj9nqfu 105 8 group group NN cord-006393-jcj9nqfu 105 9 and and CC cord-006393-jcj9nqfu 105 10 22 22 CD cord-006393-jcj9nqfu 105 11 in in IN cord-006393-jcj9nqfu 105 12 the the DT cord-006393-jcj9nqfu 105 13 high high JJ cord-006393-jcj9nqfu 105 14 - - HYPH cord-006393-jcj9nqfu 105 15 dose dose NN cord-006393-jcj9nqfu 105 16 group group NN cord-006393-jcj9nqfu 105 17 . . . cord-006393-jcj9nqfu 106 1 We -PRON- PRP cord-006393-jcj9nqfu 106 2 observed observe VBD cord-006393-jcj9nqfu 106 3 no no DT cord-006393-jcj9nqfu 106 4 difference difference NN cord-006393-jcj9nqfu 106 5 in in IN cord-006393-jcj9nqfu 106 6 the the DT cord-006393-jcj9nqfu 106 7 number number NN cord-006393-jcj9nqfu 106 8 of of IN cord-006393-jcj9nqfu 106 9 patients patient NNS cord-006393-jcj9nqfu 106 10 who who WP cord-006393-jcj9nqfu 106 11 became become VBD cord-006393-jcj9nqfu 106 12 excretors--15 excretors--15 JJ cord-006393-jcj9nqfu 106 13 in in IN cord-006393-jcj9nqfu 106 14 the the DT cord-006393-jcj9nqfu 106 15 standard standard JJ cord-006393-jcj9nqfu 106 16 - - HYPH cord-006393-jcj9nqfu 106 17 dose dose NN cord-006393-jcj9nqfu 106 18 group group NN cord-006393-jcj9nqfu 106 19 and and CC cord-006393-jcj9nqfu 106 20 17 17 CD cord-006393-jcj9nqfu 106 21 in in IN cord-006393-jcj9nqfu 106 22 the the DT cord-006393-jcj9nqfu 106 23 high high JJ cord-006393-jcj9nqfu 106 24 - - HYPH cord-006393-jcj9nqfu 106 25 dose dose NN cord-006393-jcj9nqfu 106 26 group group NN cord-006393-jcj9nqfu 106 27 . . . cord-006393-jcj9nqfu 107 1 There there EX cord-006393-jcj9nqfu 107 2 was be VBD cord-006393-jcj9nqfu 107 3 no no DT cord-006393-jcj9nqfu 107 4 difference difference NN cord-006393-jcj9nqfu 107 5 in in IN cord-006393-jcj9nqfu 107 6 the the DT cord-006393-jcj9nqfu 107 7 number number NN cord-006393-jcj9nqfu 107 8 of of IN cord-006393-jcj9nqfu 107 9 patients patient NNS cord-006393-jcj9nqfu 107 10 that that WDT cord-006393-jcj9nqfu 107 11 developed develop VBD cord-006393-jcj9nqfu 107 12 systemic systemic JJ cord-006393-jcj9nqfu 107 13 disease disease NN cord-006393-jcj9nqfu 107 14 or or CC cord-006393-jcj9nqfu 107 15 in in IN cord-006393-jcj9nqfu 107 16 the the DT cord-006393-jcj9nqfu 107 17 number number NN cord-006393-jcj9nqfu 107 18 of of IN cord-006393-jcj9nqfu 107 19 fatalities fatality NNS cord-006393-jcj9nqfu 107 20 observed observe VBD cord-006393-jcj9nqfu 107 21 . . . cord-006393-jcj9nqfu 108 1 Thus thus RB cord-006393-jcj9nqfu 108 2 , , , cord-006393-jcj9nqfu 108 3 a a DT cord-006393-jcj9nqfu 108 4 higher high JJR cord-006393-jcj9nqfu 108 5 dose dose NN cord-006393-jcj9nqfu 108 6 of of IN cord-006393-jcj9nqfu 108 7 antibody antibody NN cord-006393-jcj9nqfu 108 8 does do VBZ cord-006393-jcj9nqfu 108 9 not not RB cord-006393-jcj9nqfu 108 10 appear appear VB cord-006393-jcj9nqfu 108 11 to to TO cord-006393-jcj9nqfu 108 12 be be VB cord-006393-jcj9nqfu 108 13 more more RBR cord-006393-jcj9nqfu 108 14 beneficial beneficial JJ cord-006393-jcj9nqfu 108 15 than than IN cord-006393-jcj9nqfu 108 16 a a DT cord-006393-jcj9nqfu 108 17 lower low JJR cord-006393-jcj9nqfu 108 18 dose dose NN cord-006393-jcj9nqfu 108 19 in in IN cord-006393-jcj9nqfu 108 20 preventing prevent VBG cord-006393-jcj9nqfu 108 21 CMV CMV NNP cord-006393-jcj9nqfu 108 22 disease disease NN cord-006393-jcj9nqfu 108 23 . . . cord-006393-jcj9nqfu 109 1 New new JJ cord-006393-jcj9nqfu 109 2 strategies strategy NNS cord-006393-jcj9nqfu 109 3 need need VBP cord-006393-jcj9nqfu 109 4 to to TO cord-006393-jcj9nqfu 109 5 be be VB cord-006393-jcj9nqfu 109 6 developed develop VBN cord-006393-jcj9nqfu 109 7 to to TO cord-006393-jcj9nqfu 109 8 overcome overcome VB cord-006393-jcj9nqfu 109 9 the the DT cord-006393-jcj9nqfu 109 10 severe severe JJ cord-006393-jcj9nqfu 109 11 problem problem NN cord-006393-jcj9nqfu 109 12 presented present VBN cord-006393-jcj9nqfu 109 13 by by IN cord-006393-jcj9nqfu 109 14 the the DT cord-006393-jcj9nqfu 109 15 CMV CMV NNP cord-006393-jcj9nqfu 109 16 - - HYPH cord-006393-jcj9nqfu 109 17 seropositive seropositive JJ cord-006393-jcj9nqfu 109 18 patient patient NN cord-006393-jcj9nqfu 109 19 . . . cord-006393-jcj9nqfu 110 1 The the DT cord-006393-jcj9nqfu 110 2 treatment treatment NN cord-006393-jcj9nqfu 110 3 of of IN cord-006393-jcj9nqfu 110 4 established establish VBN cord-006393-jcj9nqfu 110 5 CMV CMV NNP cord-006393-jcj9nqfu 110 6 pneumonia pneumonia NN cord-006393-jcj9nqfu 110 7 is be VBZ cord-006393-jcj9nqfu 110 8 not not RB cord-006393-jcj9nqfu 110 9 very very RB cord-006393-jcj9nqfu 110 10 effective effective JJ cord-006393-jcj9nqfu 110 11 . . . cord-006393-jcj9nqfu 111 1 We -PRON- PRP cord-006393-jcj9nqfu 111 2 have have VBP cord-006393-jcj9nqfu 111 3 learned learn VBN cord-006393-jcj9nqfu 111 4 that that IN cord-006393-jcj9nqfu 111 5 ARA ARA NNP cord-006393-jcj9nqfu 111 6 - - HYPH cord-006393-jcj9nqfu 111 7 A A NNP cord-006393-jcj9nqfu 111 8 , , , cord-006393-jcj9nqfu 111 9 acyclovir acyclovir NN cord-006393-jcj9nqfu 111 10 , , , cord-006393-jcj9nqfu 111 11 and and CC cord-006393-jcj9nqfu 111 12 TFT TFT NNP cord-006393-jcj9nqfu 111 13 are be VBP cord-006393-jcj9nqfu 111 14 not not RB cord-006393-jcj9nqfu 111 15 effective effective JJ cord-006393-jcj9nqfu 111 16 in in IN cord-006393-jcj9nqfu 111 17 the the DT cord-006393-jcj9nqfu 111 18 therapy therapy NN cord-006393-jcj9nqfu 111 19 of of IN cord-006393-jcj9nqfu 111 20 this this DT cord-006393-jcj9nqfu 111 21 disease disease NN cord-006393-jcj9nqfu 111 22 , , , cord-006393-jcj9nqfu 111 23 although although IN cord-006393-jcj9nqfu 111 24 acyclovir acyclovir NNP cord-006393-jcj9nqfu 111 25 might may MD cord-006393-jcj9nqfu 111 26 be be VB cord-006393-jcj9nqfu 111 27 effective effective JJ cord-006393-jcj9nqfu 111 28 as as IN cord-006393-jcj9nqfu 111 29 a a DT cord-006393-jcj9nqfu 111 30 preventive preventive JJ cord-006393-jcj9nqfu 111 31 agent agent NN cord-006393-jcj9nqfu 111 32 . . . cord-006393-jcj9nqfu 112 1 IVIG IVIG NNP cord-006393-jcj9nqfu 112 2 alone alone RB cord-006393-jcj9nqfu 112 3 is be VBZ cord-006393-jcj9nqfu 112 4 as as RB cord-006393-jcj9nqfu 112 5 effective effective JJ cord-006393-jcj9nqfu 112 6 as as IN cord-006393-jcj9nqfu 112 7 9(l,3-dihydroxy-2-proxymethyl 9(l,3-dihydroxy-2-proxymethyl CD cord-006393-jcj9nqfu 112 8 ) ) -RRB- cord-006393-jcj9nqfu 112 9 guanine guanine NN cord-006393-jcj9nqfu 112 10 ( ( -LRB- cord-006393-jcj9nqfu 112 11 DHPG DHPG NNP cord-006393-jcj9nqfu 112 12 ) ) -RRB- cord-006393-jcj9nqfu 112 13 alone alone RB cord-006393-jcj9nqfu 112 14 in in IN cord-006393-jcj9nqfu 112 15 treating treat VBG cord-006393-jcj9nqfu 112 16 established establish VBN cord-006393-jcj9nqfu 112 17 CMV CMV NNP cord-006393-jcj9nqfu 112 18 pneumonia pneumonia NN cord-006393-jcj9nqfu 112 19 , , , cord-006393-jcj9nqfu 112 20 but but CC cord-006393-jcj9nqfu 112 21 surprisingly surprisingly RB cord-006393-jcj9nqfu 112 22 , , , cord-006393-jcj9nqfu 112 23 the the DT cord-006393-jcj9nqfu 112 24 combination combination NN cord-006393-jcj9nqfu 112 25 of of IN cord-006393-jcj9nqfu 112 26 IVIG IVIG NNP cord-006393-jcj9nqfu 112 27 and and CC cord-006393-jcj9nqfu 112 28 DHPG DHPG NNP cord-006393-jcj9nqfu 112 29 is be VBZ cord-006393-jcj9nqfu 112 30 quite quite RB cord-006393-jcj9nqfu 112 31 effective effective JJ cord-006393-jcj9nqfu 112 32 , , , cord-006393-jcj9nqfu 112 33 and and CC cord-006393-jcj9nqfu 112 34 in in IN cord-006393-jcj9nqfu 112 35 a a DT cord-006393-jcj9nqfu 112 36 number number NN cord-006393-jcj9nqfu 112 37 of of IN cord-006393-jcj9nqfu 112 38 studies study NNS cord-006393-jcj9nqfu 112 39 it -PRON- PRP cord-006393-jcj9nqfu 112 40 has have VBZ cord-006393-jcj9nqfu 112 41 reduced reduce VBN cord-006393-jcj9nqfu 112 42 the the DT cord-006393-jcj9nqfu 112 43 mortality mortality NN cord-006393-jcj9nqfu 112 44 rate rate NN cord-006393-jcj9nqfu 112 45 from from IN cord-006393-jcj9nqfu 112 46 85 85 CD cord-006393-jcj9nqfu 112 47 to to TO cord-006393-jcj9nqfu 112 48 50 50 CD cord-006393-jcj9nqfu 112 49 - - SYM cord-006393-jcj9nqfu 112 50 60 60 CD cord-006393-jcj9nqfu 112 51 % % NN cord-006393-jcj9nqfu 112 52 ( ( -LRB- cord-006393-jcj9nqfu 112 53 8 8 CD cord-006393-jcj9nqfu 112 54 , , , cord-006393-jcj9nqfu 112 55 9 9 CD cord-006393-jcj9nqfu 112 56 ) ) -RRB- cord-006393-jcj9nqfu 112 57 . . . cord-006393-jcj9nqfu 113 1 Hemorrhagic hemorrhagic JJ cord-006393-jcj9nqfu 113 2 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 113 3 is be VBZ cord-006393-jcj9nqfu 113 4 the the DT cord-006393-jcj9nqfu 113 5 other other JJ cord-006393-jcj9nqfu 113 6 major major JJ cord-006393-jcj9nqfu 113 7 viral viral JJ cord-006393-jcj9nqfu 113 8 complication complication NN cord-006393-jcj9nqfu 113 9 in in IN cord-006393-jcj9nqfu 113 10 the the DT cord-006393-jcj9nqfu 113 11 early early JJ cord-006393-jcj9nqfu 113 12 postengraftment postengraftment NN cord-006393-jcj9nqfu 113 13 phase phase NN cord-006393-jcj9nqfu 113 14 ( ( -LRB- cord-006393-jcj9nqfu 113 15 10 10 CD cord-006393-jcj9nqfu 113 16 ) ) -RRB- cord-006393-jcj9nqfu 113 17 . . . cord-006393-jcj9nqfu 114 1 The the DT cord-006393-jcj9nqfu 114 2 mortality mortality NN cord-006393-jcj9nqfu 114 3 is be VBZ cord-006393-jcj9nqfu 114 4 relatively relatively RB cord-006393-jcj9nqfu 114 5 high high JJ cord-006393-jcj9nqfu 114 6 ( ( -LRB- cord-006393-jcj9nqfu 114 7 29 29 CD cord-006393-jcj9nqfu 114 8 % % NN cord-006393-jcj9nqfu 114 9 ) ) -RRB- cord-006393-jcj9nqfu 114 10 even even RB cord-006393-jcj9nqfu 114 11 in in IN cord-006393-jcj9nqfu 114 12 the the DT cord-006393-jcj9nqfu 114 13 absence absence NN cord-006393-jcj9nqfu 114 14 of of IN cord-006393-jcj9nqfu 114 15 acute acute JJ cord-006393-jcj9nqfu 114 16 GVHD GVHD NNP cord-006393-jcj9nqfu 114 17 . . . cord-006393-jcj9nqfu 115 1 A a DT cord-006393-jcj9nqfu 115 2 number number NN cord-006393-jcj9nqfu 115 3 of of IN cord-006393-jcj9nqfu 115 4 viruses virus NNS cord-006393-jcj9nqfu 115 5 ( ( -LRB- cord-006393-jcj9nqfu 115 6 such such JJ cord-006393-jcj9nqfu 115 7 as as IN cord-006393-jcj9nqfu 115 8 rotavirus rotavirus NN cord-006393-jcj9nqfu 115 9 ) ) -RRB- cord-006393-jcj9nqfu 115 10 are be VBP cord-006393-jcj9nqfu 115 11 associated associate VBN cord-006393-jcj9nqfu 115 12 with with IN cord-006393-jcj9nqfu 115 13 hemorrhagic hemorrhagic JJ cord-006393-jcj9nqfu 115 14 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 115 15 , , , cord-006393-jcj9nqfu 115 16 but but CC cord-006393-jcj9nqfu 115 17 recently recently RB cord-006393-jcj9nqfu 115 18 CMV CMV NNP cord-006393-jcj9nqfu 115 19 is be VBZ cord-006393-jcj9nqfu 115 20 becoming become VBG cord-006393-jcj9nqfu 115 21 prevalent prevalent JJ cord-006393-jcj9nqfu 115 22 . . . cord-006393-jcj9nqfu 116 1 About about RB cord-006393-jcj9nqfu 116 2 half half NN cord-006393-jcj9nqfu 116 3 of of IN cord-006393-jcj9nqfu 116 4 the the DT cord-006393-jcj9nqfu 116 5 cases case NNS cord-006393-jcj9nqfu 116 6 of of IN cord-006393-jcj9nqfu 116 7 hemorrhagic hemorrhagic JJ cord-006393-jcj9nqfu 116 8 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 116 9 in in IN cord-006393-jcj9nqfu 116 10 our -PRON- PRP$ cord-006393-jcj9nqfu 116 11 own own JJ cord-006393-jcj9nqfu 116 12 patient patient JJ cord-006393-jcj9nqfu 116 13 population population NN cord-006393-jcj9nqfu 116 14 are be VBP cord-006393-jcj9nqfu 116 15 now now RB cord-006393-jcj9nqfu 116 16 due due JJ cord-006393-jcj9nqfu 116 17 to to IN cord-006393-jcj9nqfu 116 18 CMV CMV NNP cord-006393-jcj9nqfu 116 19 ; ; : cord-006393-jcj9nqfu 116 20 the the DT cord-006393-jcj9nqfu 116 21 remainder remainder NN cord-006393-jcj9nqfu 116 22 are be VBP cord-006393-jcj9nqfu 116 23 split split VBN cord-006393-jcj9nqfu 116 24 between between IN cord-006393-jcj9nqfu 116 25 rotavirus rotavirus NN cord-006393-jcj9nqfu 116 26 and and CC cord-006393-jcj9nqfu 116 27 adenovirus adenovirus NN cord-006393-jcj9nqfu 116 28 . . . cord-006393-jcj9nqfu 117 1 Effective effective JJ cord-006393-jcj9nqfu 117 2 measures measure NNS cord-006393-jcj9nqfu 117 3 to to TO cord-006393-jcj9nqfu 117 4 prevent prevent VB cord-006393-jcj9nqfu 117 5 this this DT cord-006393-jcj9nqfu 117 6 syndrome syndrome NN cord-006393-jcj9nqfu 117 7 might may MD cord-006393-jcj9nqfu 117 8 include include VB cord-006393-jcj9nqfu 117 9 the the DT cord-006393-jcj9nqfu 117 10 following follow VBG cord-006393-jcj9nqfu 117 11 : : : cord-006393-jcj9nqfu 117 12 strict strict JJ cord-006393-jcj9nqfu 117 13 isolation isolation NN cord-006393-jcj9nqfu 117 14 , , , cord-006393-jcj9nqfu 117 15 effective effective JJ cord-006393-jcj9nqfu 117 16 prevention prevention NN cord-006393-jcj9nqfu 117 17 of of IN cord-006393-jcj9nqfu 117 18 GVHD GVHD NNP cord-006393-jcj9nqfu 117 19 ( ( -LRB- cord-006393-jcj9nqfu 117 20 since since IN cord-006393-jcj9nqfu 117 21 GVHD GVHD NNP cord-006393-jcj9nqfu 117 22 might may MD cord-006393-jcj9nqfu 117 23 well well RB cord-006393-jcj9nqfu 117 24 set set VB cord-006393-jcj9nqfu 117 25 the the DT cord-006393-jcj9nqfu 117 26 stage stage NN cord-006393-jcj9nqfu 117 27 for for IN cord-006393-jcj9nqfu 117 28 hemorrhagic hemorrhagic JJ cord-006393-jcj9nqfu 117 29 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 117 30 ) ) -RRB- cord-006393-jcj9nqfu 117 31 , , , cord-006393-jcj9nqfu 117 32 and and CC cord-006393-jcj9nqfu 117 33 possibly possibly RB cord-006393-jcj9nqfu 117 34 therapy therapy NN cord-006393-jcj9nqfu 117 35 with with IN cord-006393-jcj9nqfu 117 36 orally orally RB cord-006393-jcj9nqfu 117 37 administered administer VBN cord-006393-jcj9nqfu 117 38 immune immune JJ cord-006393-jcj9nqfu 117 39 globulin globulin NN cord-006393-jcj9nqfu 117 40 . . . cord-006393-jcj9nqfu 118 1 There there EX cord-006393-jcj9nqfu 118 2 might may MD cord-006393-jcj9nqfu 118 3 be be VB cord-006393-jcj9nqfu 118 4 a a DT cord-006393-jcj9nqfu 118 5 rationale rationale NN cord-006393-jcj9nqfu 118 6 for for IN cord-006393-jcj9nqfu 118 7 such such PDT cord-006393-jcj9nqfu 118 8 a a DT cord-006393-jcj9nqfu 118 9 therapy therapy NN cord-006393-jcj9nqfu 118 10 if if IN cord-006393-jcj9nqfu 118 11 we -PRON- PRP cord-006393-jcj9nqfu 118 12 consider consider VBP cord-006393-jcj9nqfu 118 13 that that IN cord-006393-jcj9nqfu 118 14 the the DT cord-006393-jcj9nqfu 118 15 gastrointestinal gastrointestinal JJ cord-006393-jcj9nqfu 118 16 tract tract NN cord-006393-jcj9nqfu 118 17 is be VBZ cord-006393-jcj9nqfu 118 18 severely severely RB cord-006393-jcj9nqfu 118 19 injured injure VBN cord-006393-jcj9nqfu 118 20 after after IN cord-006393-jcj9nqfu 118 21 transplantation transplantation NN cord-006393-jcj9nqfu 118 22 . . . cord-006393-jcj9nqfu 119 1 The the DT cord-006393-jcj9nqfu 119 2 preparative preparative JJ cord-006393-jcj9nqfu 119 3 therapy therapy NN cord-006393-jcj9nqfu 119 4 as as RB cord-006393-jcj9nqfu 119 5 well well RB cord-006393-jcj9nqfu 119 6 as as IN cord-006393-jcj9nqfu 119 7 GVHD GVHD NNP cord-006393-jcj9nqfu 119 8 have have VBP cord-006393-jcj9nqfu 119 9 caused cause VBN cord-006393-jcj9nqfu 119 10 severe severe JJ cord-006393-jcj9nqfu 119 11 mucosal mucosal JJ cord-006393-jcj9nqfu 119 12 injury injury NN cord-006393-jcj9nqfu 119 13 . . . cord-006393-jcj9nqfu 120 1 The the DT cord-006393-jcj9nqfu 120 2 Peyer Peyer NNP cord-006393-jcj9nqfu 120 3 's 's POS cord-006393-jcj9nqfu 120 4 patches patch NNS cord-006393-jcj9nqfu 120 5 and and CC cord-006393-jcj9nqfu 120 6 other other JJ cord-006393-jcj9nqfu 120 7 gutassociated gutassociate VBN cord-006393-jcj9nqfu 120 8 lymphoid lymphoid JJ cord-006393-jcj9nqfu 120 9 tissues tissue NNS cord-006393-jcj9nqfu 120 10 have have VBP cord-006393-jcj9nqfu 120 11 been be VBN cord-006393-jcj9nqfu 120 12 destroyed destroy VBN cord-006393-jcj9nqfu 120 13 and and CC cord-006393-jcj9nqfu 120 14 must must MD cord-006393-jcj9nqfu 120 15 be be VB cord-006393-jcj9nqfu 120 16 rebuilt rebuild VBN cord-006393-jcj9nqfu 120 17 . . . cord-006393-jcj9nqfu 121 1 In in IN cord-006393-jcj9nqfu 121 2 the the DT cord-006393-jcj9nqfu 121 3 lamina lamina NNP cord-006393-jcj9nqfu 121 4 propria propria NNP cord-006393-jcj9nqfu 121 5 IgA IgA NNP cord-006393-jcj9nqfu 121 6 - - HYPH cord-006393-jcj9nqfu 121 7 and and CC cord-006393-jcj9nqfu 121 8 IgM IgM NNP cord-006393-jcj9nqfu 121 9 - - HYPH cord-006393-jcj9nqfu 121 10 producing produce VBG cord-006393-jcj9nqfu 121 11 plasma plasma NN cord-006393-jcj9nqfu 121 12 cells cell NNS cord-006393-jcj9nqfu 121 13 have have VBP cord-006393-jcj9nqfu 121 14 disappeared disappear VBN cord-006393-jcj9nqfu 121 15 . . . cord-006393-jcj9nqfu 122 1 Most most RBS cord-006393-jcj9nqfu 122 2 importantly importantly RB cord-006393-jcj9nqfu 122 3 the the DT cord-006393-jcj9nqfu 122 4 degradation degradation NN cord-006393-jcj9nqfu 122 5 of of IN cord-006393-jcj9nqfu 122 6 IgG igg NN cord-006393-jcj9nqfu 122 7 when when WRB cord-006393-jcj9nqfu 122 8 administered administer VBN cord-006393-jcj9nqfu 122 9 orally orally RB cord-006393-jcj9nqfu 122 10 is be VBZ cord-006393-jcj9nqfu 122 11 much much RB cord-006393-jcj9nqfu 122 12 impaired impaired JJ cord-006393-jcj9nqfu 122 13 in in IN cord-006393-jcj9nqfu 122 14 such such PDT cord-006393-jcj9nqfu 122 15 a a DT cord-006393-jcj9nqfu 122 16 devastated devastated JJ cord-006393-jcj9nqfu 122 17 gut gut NN cord-006393-jcj9nqfu 122 18 . . . cord-006393-jcj9nqfu 123 1 It -PRON- PRP cord-006393-jcj9nqfu 123 2 has have VBZ cord-006393-jcj9nqfu 123 3 been be VBN cord-006393-jcj9nqfu 123 4 shown show VBN cord-006393-jcj9nqfu 123 5 that that IN cord-006393-jcj9nqfu 123 6 IgG IgG NNP cord-006393-jcj9nqfu 123 7 antibody antibody NN cord-006393-jcj9nqfu 123 8 survives survive VBZ cord-006393-jcj9nqfu 123 9 passage passage NN cord-006393-jcj9nqfu 123 10 through through IN cord-006393-jcj9nqfu 123 11 the the DT cord-006393-jcj9nqfu 123 12 gastrointestinal gastrointestinal JJ cord-006393-jcj9nqfu 123 13 tract tract NN cord-006393-jcj9nqfu 123 14 and and CC cord-006393-jcj9nqfu 123 15 emerges emerge VBZ cord-006393-jcj9nqfu 123 16 as as IN cord-006393-jcj9nqfu 123 17 an an DT cord-006393-jcj9nqfu 123 18 intact intact JJ cord-006393-jcj9nqfu 123 19 molecule molecule NN cord-006393-jcj9nqfu 123 20 . . . cord-006393-jcj9nqfu 124 1 This this DT cord-006393-jcj9nqfu 124 2 led lead VBD cord-006393-jcj9nqfu 124 3 us -PRON- PRP cord-006393-jcj9nqfu 124 4 to to TO cord-006393-jcj9nqfu 124 5 consider consider VB cord-006393-jcj9nqfu 124 6 administering administer VBG cord-006393-jcj9nqfu 124 7 IVIG IVIG NNP cord-006393-jcj9nqfu 124 8 orally orally RB cord-006393-jcj9nqfu 124 9 to to IN cord-006393-jcj9nqfu 124 10 patients patient NNS cord-006393-jcj9nqfu 124 11 at at IN cord-006393-jcj9nqfu 124 12 risk risk NN cord-006393-jcj9nqfu 124 13 for for IN cord-006393-jcj9nqfu 124 14 hemorrhagic hemorrhagic JJ cord-006393-jcj9nqfu 124 15 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 124 16 . . . cord-006393-jcj9nqfu 125 1 We -PRON- PRP cord-006393-jcj9nqfu 125 2 conducted conduct VBD cord-006393-jcj9nqfu 125 3 a a DT cord-006393-jcj9nqfu 125 4 pilot pilot NN cord-006393-jcj9nqfu 125 5 trial trial NN cord-006393-jcj9nqfu 125 6 in in IN cord-006393-jcj9nqfu 125 7 which which WDT cord-006393-jcj9nqfu 125 8 30 30 CD cord-006393-jcj9nqfu 125 9 patients patient NNS cord-006393-jcj9nqfu 125 10 were be VBD cord-006393-jcj9nqfu 125 11 given give VBN cord-006393-jcj9nqfu 125 12 IVIG IVIG NNP cord-006393-jcj9nqfu 125 13 orally orally RB cord-006393-jcj9nqfu 125 14 at at IN cord-006393-jcj9nqfu 125 15 a a DT cord-006393-jcj9nqfu 125 16 dose dose NN cord-006393-jcj9nqfu 125 17 of of IN cord-006393-jcj9nqfu 125 18 50 50 CD cord-006393-jcj9nqfu 125 19 mg mg NNP cord-006393-jcj9nqfu 125 20 / / SYM cord-006393-jcj9nqfu 125 21 kg kg NN cord-006393-jcj9nqfu 125 22 for for IN cord-006393-jcj9nqfu 125 23 4 4 CD cord-006393-jcj9nqfu 125 24 weeks week NNS cord-006393-jcj9nqfu 125 25 . . . cord-006393-jcj9nqfu 126 1 Prior prior RB cord-006393-jcj9nqfu 126 2 to to IN cord-006393-jcj9nqfu 126 3 administration administration NN cord-006393-jcj9nqfu 126 4 of of IN cord-006393-jcj9nqfu 126 5 IVIG IVIG NNP cord-006393-jcj9nqfu 126 6 we -PRON- PRP cord-006393-jcj9nqfu 126 7 could could MD cord-006393-jcj9nqfu 126 8 not not RB cord-006393-jcj9nqfu 126 9 demonstrate demonstrate VB cord-006393-jcj9nqfu 126 10 any any DT cord-006393-jcj9nqfu 126 11 IgG igg NN cord-006393-jcj9nqfu 126 12 in in IN cord-006393-jcj9nqfu 126 13 the the DT cord-006393-jcj9nqfu 126 14 stool stool NN cord-006393-jcj9nqfu 126 15 . . . cord-006393-jcj9nqfu 127 1 After after IN cord-006393-jcj9nqfu 127 2 oral oral JJ cord-006393-jcj9nqfu 127 3 administration administration NN cord-006393-jcj9nqfu 127 4 of of IN cord-006393-jcj9nqfu 127 5 IVIG IVIG NNP cord-006393-jcj9nqfu 127 6 , , , cord-006393-jcj9nqfu 127 7 20 20 CD cord-006393-jcj9nqfu 127 8 of of IN cord-006393-jcj9nqfu 127 9 30 30 CD cord-006393-jcj9nqfu 127 10 patients patient NNS cord-006393-jcj9nqfu 127 11 had have VBD cord-006393-jcj9nqfu 127 12 considerable considerable JJ cord-006393-jcj9nqfu 127 13 amounts amount NNS cord-006393-jcj9nqfu 127 14 of of IN cord-006393-jcj9nqfu 127 15 IgG igg NN cord-006393-jcj9nqfu 127 16 , , , cord-006393-jcj9nqfu 127 17 up up IN cord-006393-jcj9nqfu 127 18 to to TO cord-006393-jcj9nqfu 127 19 400 400 CD cord-006393-jcj9nqfu 127 20 mg mg NNP cord-006393-jcj9nqfu 127 21 / / SYM cord-006393-jcj9nqfu 127 22 dl dl NNP cord-006393-jcj9nqfu 127 23 , , , cord-006393-jcj9nqfu 127 24 in in IN cord-006393-jcj9nqfu 127 25 the the DT cord-006393-jcj9nqfu 127 26 stool stool NN cord-006393-jcj9nqfu 127 27 . . . cord-006393-jcj9nqfu 128 1 Eighteen eighteen CD cord-006393-jcj9nqfu 128 2 patients patient NNS cord-006393-jcj9nqfu 128 3 had have VBD cord-006393-jcj9nqfu 128 4 greater great JJR cord-006393-jcj9nqfu 128 5 than than IN cord-006393-jcj9nqfu 128 6 20 20 CD cord-006393-jcj9nqfu 128 7 mg mg NNP cord-006393-jcj9nqfu 128 8 / / SYM cord-006393-jcj9nqfu 128 9 dl dl NN cord-006393-jcj9nqfu 128 10 . . . cord-006393-jcj9nqfu 129 1 Only only RB cord-006393-jcj9nqfu 129 2 1 1 CD cord-006393-jcj9nqfu 129 3 of of IN cord-006393-jcj9nqfu 129 4 the the DT cord-006393-jcj9nqfu 129 5 30 30 CD cord-006393-jcj9nqfu 129 6 patients patient NNS cord-006393-jcj9nqfu 129 7 developed develop VBD cord-006393-jcj9nqfu 129 8 a a DT cord-006393-jcj9nqfu 129 9 positive positive JJ cord-006393-jcj9nqfu 129 10 adenovirus adenovirus NN cord-006393-jcj9nqfu 129 11 culture culture NN cord-006393-jcj9nqfu 129 12 and and CC cord-006393-jcj9nqfu 129 13 12 12 CD cord-006393-jcj9nqfu 129 14 patients patient NNS cord-006393-jcj9nqfu 129 15 remained remain VBD cord-006393-jcj9nqfu 129 16 afebrile afebrile JJ cord-006393-jcj9nqfu 129 17 ( ( -LRB- cord-006393-jcj9nqfu 129 18 11 11 CD cord-006393-jcj9nqfu 129 19 ) ) -RRB- cord-006393-jcj9nqfu 129 20 . . . cord-006393-jcj9nqfu 130 1 We -PRON- PRP cord-006393-jcj9nqfu 130 2 have have VBP cord-006393-jcj9nqfu 130 3 just just RB cord-006393-jcj9nqfu 130 4 completed complete VBN cord-006393-jcj9nqfu 130 5 a a DT cord-006393-jcj9nqfu 130 6 double double JJ cord-006393-jcj9nqfu 130 7 - - HYPH cord-006393-jcj9nqfu 130 8 blind blind JJ cord-006393-jcj9nqfu 130 9 , , , cord-006393-jcj9nqfu 130 10 randomized randomized JJ cord-006393-jcj9nqfu 130 11 study study NN cord-006393-jcj9nqfu 130 12 comparing compare VBG cord-006393-jcj9nqfu 130 13 orally orally RB cord-006393-jcj9nqfu 130 14 administered administer VBN cord-006393-jcj9nqfu 130 15 IVIG IVIG NNP cord-006393-jcj9nqfu 130 16 to to IN cord-006393-jcj9nqfu 130 17 placebo placebo NN cord-006393-jcj9nqfu 130 18 . . . cord-006393-jcj9nqfu 131 1 Hopefully hopefully RB cord-006393-jcj9nqfu 131 2 , , , cord-006393-jcj9nqfu 131 3 the the DT cord-006393-jcj9nqfu 131 4 analysis analysis NN cord-006393-jcj9nqfu 131 5 of of IN cord-006393-jcj9nqfu 131 6 the the DT cord-006393-jcj9nqfu 131 7 study study NN cord-006393-jcj9nqfu 131 8 will will MD cord-006393-jcj9nqfu 131 9 show show VB cord-006393-jcj9nqfu 131 10 that that IN cord-006393-jcj9nqfu 131 11 the the DT cord-006393-jcj9nqfu 131 12 concept concept NN cord-006393-jcj9nqfu 131 13 of of IN cord-006393-jcj9nqfu 131 14 oral oral JJ cord-006393-jcj9nqfu 131 15 administration administration NN cord-006393-jcj9nqfu 131 16 of of IN cord-006393-jcj9nqfu 131 17 immune immune JJ cord-006393-jcj9nqfu 131 18 globulin globulin NN cord-006393-jcj9nqfu 131 19 has have VBZ cord-006393-jcj9nqfu 131 20 some some DT cord-006393-jcj9nqfu 131 21 merit merit NN cord-006393-jcj9nqfu 131 22 . . . cord-006393-jcj9nqfu 132 1 The the DT cord-006393-jcj9nqfu 132 2 immunobiology immunobiology NN cord-006393-jcj9nqfu 132 3 of of IN cord-006393-jcj9nqfu 132 4 phase phase NN cord-006393-jcj9nqfu 132 5 III III NNP cord-006393-jcj9nqfu 132 6 , , , cord-006393-jcj9nqfu 132 7 the the DT cord-006393-jcj9nqfu 132 8 late late JJ cord-006393-jcj9nqfu 132 9 postengraftment postengraftment NN cord-006393-jcj9nqfu 132 10 phase phase NN cord-006393-jcj9nqfu 132 11 , , , cord-006393-jcj9nqfu 132 12 is be VBZ cord-006393-jcj9nqfu 132 13 characterized characterize VBN cord-006393-jcj9nqfu 132 14 by by IN cord-006393-jcj9nqfu 132 15 a a DT cord-006393-jcj9nqfu 132 16 continuous continuous JJ cord-006393-jcj9nqfu 132 17 impairment impairment NN cord-006393-jcj9nqfu 132 18 of of IN cord-006393-jcj9nqfu 132 19 the the DT cord-006393-jcj9nqfu 132 20 T T NNP cord-006393-jcj9nqfu 132 21 helper helper NN cord-006393-jcj9nqfu 132 22 - - HYPH cord-006393-jcj9nqfu 132 23 cell cell NN cord-006393-jcj9nqfu 132 24 function function NN cord-006393-jcj9nqfu 132 25 , , , cord-006393-jcj9nqfu 132 26 a a DT cord-006393-jcj9nqfu 132 27 continuous continuous JJ cord-006393-jcj9nqfu 132 28 defect defect NN cord-006393-jcj9nqfu 132 29 in in IN cord-006393-jcj9nqfu 132 30 humoral humoral JJ cord-006393-jcj9nqfu 132 31 immunity immunity NN cord-006393-jcj9nqfu 132 32 , , , cord-006393-jcj9nqfu 132 33 and and CC cord-006393-jcj9nqfu 132 34 , , , cord-006393-jcj9nqfu 132 35 in in IN cord-006393-jcj9nqfu 132 36 particular particular JJ cord-006393-jcj9nqfu 132 37 , , , cord-006393-jcj9nqfu 132 38 the the DT cord-006393-jcj9nqfu 132 39 development development NN cord-006393-jcj9nqfu 132 40 of of IN cord-006393-jcj9nqfu 132 41 chronic chronic JJ cord-006393-jcj9nqfu 132 42 GVHD GVHD NNP cord-006393-jcj9nqfu 132 43 . . . cord-006393-jcj9nqfu 133 1 A a DT cord-006393-jcj9nqfu 133 2 number number NN cord-006393-jcj9nqfu 133 3 of of IN cord-006393-jcj9nqfu 133 4 infections infection NNS cord-006393-jcj9nqfu 133 5 are be VBP cord-006393-jcj9nqfu 133 6 seen see VBN cord-006393-jcj9nqfu 133 7 in in IN cord-006393-jcj9nqfu 133 8 this this DT cord-006393-jcj9nqfu 133 9 posttransplant posttransplant NN cord-006393-jcj9nqfu 133 10 phase phase NN cord-006393-jcj9nqfu 133 11 , , , cord-006393-jcj9nqfu 133 12 especially especially RB cord-006393-jcj9nqfu 133 13 sinopulmonary sinopulmonary JJ cord-006393-jcj9nqfu 133 14 infections infection NNS cord-006393-jcj9nqfu 133 15 with with IN cord-006393-jcj9nqfu 133 16 encapsulated encapsulate VBN cord-006393-jcj9nqfu 133 17 organisms organism NNS cord-006393-jcj9nqfu 133 18 such such JJ cord-006393-jcj9nqfu 133 19 as as IN cord-006393-jcj9nqfu 133 20 Streptococcus streptococcus NN cord-006393-jcj9nqfu 133 21 pneumoniae pneumoniae NN cord-006393-jcj9nqfu 133 22 . . . cord-006393-jcj9nqfu 134 1 Initially initially RB cord-006393-jcj9nqfu 134 2 we -PRON- PRP cord-006393-jcj9nqfu 134 3 thought think VBD cord-006393-jcj9nqfu 134 4 that that IN cord-006393-jcj9nqfu 134 5 the the DT cord-006393-jcj9nqfu 134 6 hyposplenism hyposplenism NN cord-006393-jcj9nqfu 134 7 associated associate VBN cord-006393-jcj9nqfu 134 8 with with IN cord-006393-jcj9nqfu 134 9 chronic chronic JJ cord-006393-jcj9nqfu 134 10 GVHD GVHD NNP cord-006393-jcj9nqfu 134 11 was be VBD cord-006393-jcj9nqfu 134 12 responsible responsible JJ cord-006393-jcj9nqfu 134 13 for for IN cord-006393-jcj9nqfu 134 14 these these DT cord-006393-jcj9nqfu 134 15 infections infection NNS cord-006393-jcj9nqfu 134 16 ( ( -LRB- cord-006393-jcj9nqfu 134 17 12 12 CD cord-006393-jcj9nqfu 134 18 ) ) -RRB- cord-006393-jcj9nqfu 134 19 . . . cord-006393-jcj9nqfu 135 1 However however RB cord-006393-jcj9nqfu 135 2 , , , cord-006393-jcj9nqfu 135 3 we -PRON- PRP cord-006393-jcj9nqfu 135 4 considered consider VBD cord-006393-jcj9nqfu 135 5 that that IN cord-006393-jcj9nqfu 135 6 there there EX cord-006393-jcj9nqfu 135 7 might may MD cord-006393-jcj9nqfu 135 8 also also RB cord-006393-jcj9nqfu 135 9 be be VB cord-006393-jcj9nqfu 135 10 an an DT cord-006393-jcj9nqfu 135 11 association association NN cord-006393-jcj9nqfu 135 12 with with IN cord-006393-jcj9nqfu 135 13 an an DT cord-006393-jcj9nqfu 135 14 IgGsubclass IgGsubclass NNP cord-006393-jcj9nqfu 135 15 deficiency deficiency NN cord-006393-jcj9nqfu 135 16 and and CC cord-006393-jcj9nqfu 135 17 we -PRON- PRP cord-006393-jcj9nqfu 135 18 conducted conduct VBD cord-006393-jcj9nqfu 135 19 a a DT cord-006393-jcj9nqfu 135 20 small small JJ cord-006393-jcj9nqfu 135 21 study study NN cord-006393-jcj9nqfu 135 22 . . . cord-006393-jcj9nqfu 136 1 IgG IgG NNP cord-006393-jcj9nqfu 136 2 subclasses subclass NNS cord-006393-jcj9nqfu 136 3 were be VBD cord-006393-jcj9nqfu 136 4 determined determine VBN cord-006393-jcj9nqfu 136 5 in in IN cord-006393-jcj9nqfu 136 6 28 28 CD cord-006393-jcj9nqfu 136 7 patients patient NNS cord-006393-jcj9nqfu 136 8 . . . cord-006393-jcj9nqfu 137 1 One one CD cord-006393-jcj9nqfu 137 2 group group NN cord-006393-jcj9nqfu 137 3 of of IN cord-006393-jcj9nqfu 137 4 14 14 CD cord-006393-jcj9nqfu 137 5 patients patient NNS cord-006393-jcj9nqfu 137 6 showed show VBD cord-006393-jcj9nqfu 137 7 a a DT cord-006393-jcj9nqfu 137 8 marked mark VBN cord-006393-jcj9nqfu 137 9 IgG2-subclass IgG2-subclass NNP cord-006393-jcj9nqfu 137 10 deficiency deficiency NN cord-006393-jcj9nqfu 137 11 with with IN cord-006393-jcj9nqfu 137 12 a a DT cord-006393-jcj9nqfu 137 13 very very RB cord-006393-jcj9nqfu 137 14 high high JJ cord-006393-jcj9nqfu 137 15 infection infection NN cord-006393-jcj9nqfu 137 16 rate rate NN cord-006393-jcj9nqfu 137 17 . . . cord-006393-jcj9nqfu 138 1 Twelve twelve CD cord-006393-jcj9nqfu 138 2 of of IN cord-006393-jcj9nqfu 138 3 these these DT cord-006393-jcj9nqfu 138 4 14 14 CD cord-006393-jcj9nqfu 138 5 patients patient NNS cord-006393-jcj9nqfu 138 6 developed develop VBD cord-006393-jcj9nqfu 138 7 infections infection NNS cord-006393-jcj9nqfu 138 8 with with IN cord-006393-jcj9nqfu 138 9 gram gram NN cord-006393-jcj9nqfu 138 10 - - HYPH cord-006393-jcj9nqfu 138 11 positive positive JJ cord-006393-jcj9nqfu 138 12 organisms organism NNS cord-006393-jcj9nqfu 138 13 . . . cord-006393-jcj9nqfu 139 1 Another another DT cord-006393-jcj9nqfu 139 2 group group NN cord-006393-jcj9nqfu 139 3 of of IN cord-006393-jcj9nqfu 139 4 14 14 CD cord-006393-jcj9nqfu 139 5 patients patient NNS cord-006393-jcj9nqfu 139 6 with with IN cord-006393-jcj9nqfu 139 7 no no DT cord-006393-jcj9nqfu 139 8 IgG2-subclass IgG2-subclass NNP cord-006393-jcj9nqfu 139 9 deficiency deficiency NN cord-006393-jcj9nqfu 139 10 had have VBD cord-006393-jcj9nqfu 139 11 a a DT cord-006393-jcj9nqfu 139 12 very very RB cord-006393-jcj9nqfu 139 13 low low JJ cord-006393-jcj9nqfu 139 14 infection infection NN cord-006393-jcj9nqfu 139 15 rate rate NN cord-006393-jcj9nqfu 139 16 , , , cord-006393-jcj9nqfu 139 17 with with IN cord-006393-jcj9nqfu 139 18 only only RB cord-006393-jcj9nqfu 139 19 2 2 CD cord-006393-jcj9nqfu 139 20 of of IN cord-006393-jcj9nqfu 139 21 14 14 CD cord-006393-jcj9nqfu 139 22 being be VBG cord-006393-jcj9nqfu 139 23 infected infect VBN cord-006393-jcj9nqfu 139 24 . . . cord-006393-jcj9nqfu 140 1 Studying study VBG cord-006393-jcj9nqfu 140 2 these these DT cord-006393-jcj9nqfu 140 3 patients patient NNS cord-006393-jcj9nqfu 140 4 further far RBR cord-006393-jcj9nqfu 140 5 we -PRON- PRP cord-006393-jcj9nqfu 140 6 could could MD cord-006393-jcj9nqfu 140 7 show show VB cord-006393-jcj9nqfu 140 8 that that IN cord-006393-jcj9nqfu 140 9 the the DT cord-006393-jcj9nqfu 140 10 patients patient NNS cord-006393-jcj9nqfu 140 11 continued continue VBD cord-006393-jcj9nqfu 140 12 to to TO cord-006393-jcj9nqfu 140 13 show show VB cord-006393-jcj9nqfu 140 14 subclass subclass NN cord-006393-jcj9nqfu 140 15 deficiency deficiency NN cord-006393-jcj9nqfu 140 16 even even RB cord-006393-jcj9nqfu 140 17 after after IN cord-006393-jcj9nqfu 140 18 they -PRON- PRP cord-006393-jcj9nqfu 140 19 resolved resolve VBD cord-006393-jcj9nqfu 140 20 the the DT cord-006393-jcj9nqfu 140 21 infections infection NNS cord-006393-jcj9nqfu 140 22 . . . cord-006393-jcj9nqfu 141 1 However however RB cord-006393-jcj9nqfu 141 2 , , , cord-006393-jcj9nqfu 141 3 it -PRON- PRP cord-006393-jcj9nqfu 141 4 is be VBZ cord-006393-jcj9nqfu 141 5 not not RB cord-006393-jcj9nqfu 141 6 only only RB cord-006393-jcj9nqfu 141 7 IgG2 igg2 JJ cord-006393-jcj9nqfu 141 8 but but CC cord-006393-jcj9nqfu 141 9 also also RB cord-006393-jcj9nqfu 142 1 IgG4 igg4 CD cord-006393-jcj9nqfu 142 2 subclass subclass NN cord-006393-jcj9nqfu 142 3 which which WDT cord-006393-jcj9nqfu 142 4 was be VBD cord-006393-jcj9nqfu 142 5 markedly markedly RB cord-006393-jcj9nqfu 142 6 reduced reduce VBN cord-006393-jcj9nqfu 142 7 ( ( -LRB- cord-006393-jcj9nqfu 142 8 13 13 CD cord-006393-jcj9nqfu 142 9 ) ) -RRB- cord-006393-jcj9nqfu 142 10 . . . cord-006393-jcj9nqfu 143 1 To to TO cord-006393-jcj9nqfu 143 2 prevent prevent VB cord-006393-jcj9nqfu 143 3 these these DT cord-006393-jcj9nqfu 143 4 late late JJ cord-006393-jcj9nqfu 143 5 infections infection NNS cord-006393-jcj9nqfu 143 6 one one PRP cord-006393-jcj9nqfu 143 7 could could MD cord-006393-jcj9nqfu 143 8 maintain maintain VB cord-006393-jcj9nqfu 143 9 coverage coverage NN cord-006393-jcj9nqfu 143 10 against against IN cord-006393-jcj9nqfu 143 11 gram gram NN cord-006393-jcj9nqfu 143 12 - - HYPH cord-006393-jcj9nqfu 143 13 positive positive JJ cord-006393-jcj9nqfu 143 14 organisms organism NNS cord-006393-jcj9nqfu 143 15 beyond beyond IN cord-006393-jcj9nqfu 143 16 day day NN cord-006393-jcj9nqfu 143 17 I00 I00 NNP cord-006393-jcj9nqfu 143 18 and and CC cord-006393-jcj9nqfu 143 19 should should MD cord-006393-jcj9nqfu 143 20 maintain maintain VB cord-006393-jcj9nqfu 143 21 gram gram NN cord-006393-jcj9nqfu 143 22 - - HYPH cord-006393-jcj9nqfu 143 23 positive positive JJ cord-006393-jcj9nqfu 143 24 coverage coverage NN cord-006393-jcj9nqfu 143 25 for for IN cord-006393-jcj9nqfu 143 26 an an DT cord-006393-jcj9nqfu 143 27 even even RB cord-006393-jcj9nqfu 143 28 longer long JJR cord-006393-jcj9nqfu 143 29 period period NN cord-006393-jcj9nqfu 143 30 in in IN cord-006393-jcj9nqfu 143 31 patients patient NNS cord-006393-jcj9nqfu 143 32 who who WP cord-006393-jcj9nqfu 143 33 demonstrate demonstrate VBP cord-006393-jcj9nqfu 143 34 chronic chronic JJ cord-006393-jcj9nqfu 143 35 GVHD GVHD NNP cord-006393-jcj9nqfu 143 36 . . . cord-006393-jcj9nqfu 144 1 Most most RBS cord-006393-jcj9nqfu 144 2 importantly importantly RB cord-006393-jcj9nqfu 144 3 , , , cord-006393-jcj9nqfu 144 4 one one PRP cord-006393-jcj9nqfu 144 5 should should MD cord-006393-jcj9nqfu 144 6 maintain maintain VB cord-006393-jcj9nqfu 144 7 IVIG IVIG NNP cord-006393-jcj9nqfu 144 8 supplementation supplementation NN cord-006393-jcj9nqfu 144 9 beyond beyond IN cord-006393-jcj9nqfu 144 10 day day NN cord-006393-jcj9nqfu 144 11 120 120 CD cord-006393-jcj9nqfu 144 12 for for IN cord-006393-jcj9nqfu 144 13 the the DT cord-006393-jcj9nqfu 144 14 first first JJ cord-006393-jcj9nqfu 144 15 year year NN cord-006393-jcj9nqfu 144 16 . . . cord-006393-jcj9nqfu 145 1 In in IN cord-006393-jcj9nqfu 145 2 our -PRON- PRP$ cord-006393-jcj9nqfu 145 3 transplant transplant NN cord-006393-jcj9nqfu 145 4 center center NN cord-006393-jcj9nqfu 145 5 we -PRON- PRP cord-006393-jcj9nqfu 145 6 continue continue VBP cord-006393-jcj9nqfu 145 7 IVIG IVIG NNP cord-006393-jcj9nqfu 145 8 supplementation supplementation NN cord-006393-jcj9nqfu 145 9 as as RB cord-006393-jcj9nqfu 145 10 long long RB cord-006393-jcj9nqfu 145 11 as as IN cord-006393-jcj9nqfu 145 12 the the DT cord-006393-jcj9nqfu 145 13 subclass subclass NN cord-006393-jcj9nqfu 145 14 deficiency deficiency NN cord-006393-jcj9nqfu 145 15 persists persist VBZ cord-006393-jcj9nqfu 145 16 , , , cord-006393-jcj9nqfu 145 17 not not RB cord-006393-jcj9nqfu 145 18 unlike unlike IN cord-006393-jcj9nqfu 145 19 a a DT cord-006393-jcj9nqfu 145 20 patient patient NN cord-006393-jcj9nqfu 145 21 with with IN cord-006393-jcj9nqfu 145 22 an an DT cord-006393-jcj9nqfu 145 23 inborn inborn JJ cord-006393-jcj9nqfu 145 24 IgGsubclass IgGsubclass NNP cord-006393-jcj9nqfu 145 25 deficiency deficiency NN cord-006393-jcj9nqfu 145 26 syndrome syndrome NN cord-006393-jcj9nqfu 145 27 . . . cord-006393-jcj9nqfu 146 1 Utilizing utilize VBG cord-006393-jcj9nqfu 146 2 this this DT cord-006393-jcj9nqfu 146 3 strategy strategy NN cord-006393-jcj9nqfu 146 4 one one PRP cord-006393-jcj9nqfu 146 5 can can MD cord-006393-jcj9nqfu 146 6 virtually virtually RB cord-006393-jcj9nqfu 146 7 eliminate eliminate VB cord-006393-jcj9nqfu 146 8 late late JJ cord-006393-jcj9nqfu 146 9 gram gram NN cord-006393-jcj9nqfu 146 10 - - HYPH cord-006393-jcj9nqfu 146 11 positive positive JJ cord-006393-jcj9nqfu 146 12 infections infection NNS cord-006393-jcj9nqfu 146 13 . . . cord-006393-jcj9nqfu 147 1 Since since IN cord-006393-jcj9nqfu 147 2 there there EX cord-006393-jcj9nqfu 147 3 are be VBP cord-006393-jcj9nqfu 147 4 a a DT cord-006393-jcj9nqfu 147 5 number number NN cord-006393-jcj9nqfu 147 6 of of IN cord-006393-jcj9nqfu 147 7 sequential sequential JJ cord-006393-jcj9nqfu 147 8 events event NNS cord-006393-jcj9nqfu 147 9 in in IN cord-006393-jcj9nqfu 147 10 the the DT cord-006393-jcj9nqfu 147 11 immunobiology immunobiology NN cord-006393-jcj9nqfu 147 12 after after IN cord-006393-jcj9nqfu 147 13 transplantation transplantation NN cord-006393-jcj9nqfu 147 14 which which WDT cord-006393-jcj9nqfu 147 15 correlate correlate VBP cord-006393-jcj9nqfu 147 16 with with IN cord-006393-jcj9nqfu 147 17 infectious infectious JJ cord-006393-jcj9nqfu 147 18 patterns pattern NNS cord-006393-jcj9nqfu 147 19 , , , cord-006393-jcj9nqfu 147 20 it -PRON- PRP cord-006393-jcj9nqfu 147 21 should should MD cord-006393-jcj9nqfu 147 22 be be VB cord-006393-jcj9nqfu 147 23 possible possible JJ cord-006393-jcj9nqfu 147 24 to to TO cord-006393-jcj9nqfu 147 25 develop develop VB cord-006393-jcj9nqfu 147 26 rational rational JJ cord-006393-jcj9nqfu 147 27 strategies strategy NNS cord-006393-jcj9nqfu 147 28 to to TO cord-006393-jcj9nqfu 147 29 counteract counteract VB cord-006393-jcj9nqfu 147 30 the the DT cord-006393-jcj9nqfu 147 31 various various JJ cord-006393-jcj9nqfu 147 32 immune immune JJ cord-006393-jcj9nqfu 147 33 defects defect NNS cord-006393-jcj9nqfu 147 34 . . . cord-006393-jcj9nqfu 148 1 The the DT cord-006393-jcj9nqfu 148 2 prophylactic prophylactic JJ cord-006393-jcj9nqfu 148 3 and and CC cord-006393-jcj9nqfu 148 4 therapeutic therapeutic JJ cord-006393-jcj9nqfu 148 5 use use NN cord-006393-jcj9nqfu 148 6 of of IN cord-006393-jcj9nqfu 148 7 IVIG IVIG NNP cord-006393-jcj9nqfu 148 8 might may MD cord-006393-jcj9nqfu 148 9 have have VB cord-006393-jcj9nqfu 148 10 a a DT cord-006393-jcj9nqfu 148 11 central central JJ cord-006393-jcj9nqfu 148 12 role role NN cord-006393-jcj9nqfu 148 13 because because IN cord-006393-jcj9nqfu 148 14 it -PRON- PRP cord-006393-jcj9nqfu 148 15 is be VBZ cord-006393-jcj9nqfu 148 16 likely likely JJ cord-006393-jcj9nqfu 148 17 to to TO cord-006393-jcj9nqfu 148 18 affect affect VB cord-006393-jcj9nqfu 148 19 all all DT cord-006393-jcj9nqfu 148 20 phases phase NNS cord-006393-jcj9nqfu 148 21 of of IN cord-006393-jcj9nqfu 148 22 bone bone NN cord-006393-jcj9nqfu 148 23 marrow marrow NN cord-006393-jcj9nqfu 148 24 transplantation transplantation NN cord-006393-jcj9nqfu 148 25 . . . cord-006393-jcj9nqfu 149 1 We -PRON- PRP cord-006393-jcj9nqfu 149 2 know know VBP cord-006393-jcj9nqfu 149 3 that that IN cord-006393-jcj9nqfu 149 4 immune immune JJ cord-006393-jcj9nqfu 149 5 globulins globulin NNS cord-006393-jcj9nqfu 149 6 have have VBP cord-006393-jcj9nqfu 149 7 a a DT cord-006393-jcj9nqfu 149 8 beneficial beneficial JJ cord-006393-jcj9nqfu 149 9 effect effect NN cord-006393-jcj9nqfu 149 10 in in IN cord-006393-jcj9nqfu 149 11 both both CC cord-006393-jcj9nqfu 149 12 the the DT cord-006393-jcj9nqfu 149 13 prevention prevention NN cord-006393-jcj9nqfu 149 14 and and CC cord-006393-jcj9nqfu 149 15 the the DT cord-006393-jcj9nqfu 149 16 treatment treatment NN cord-006393-jcj9nqfu 149 17 of of IN cord-006393-jcj9nqfu 149 18 viral viral JJ cord-006393-jcj9nqfu 149 19 interstitial interstitial JJ cord-006393-jcj9nqfu 149 20 pneumonia pneumonia NN cord-006393-jcj9nqfu 149 21 . . . cord-006393-jcj9nqfu 150 1 It -PRON- PRP cord-006393-jcj9nqfu 150 2 is be VBZ cord-006393-jcj9nqfu 150 3 likely likely JJ cord-006393-jcj9nqfu 150 4 that that IN cord-006393-jcj9nqfu 150 5 immune immune JJ cord-006393-jcj9nqfu 150 6 globulin globulin NN cord-006393-jcj9nqfu 150 7 will will MD cord-006393-jcj9nqfu 150 8 also also RB cord-006393-jcj9nqfu 150 9 have have VB cord-006393-jcj9nqfu 150 10 a a DT cord-006393-jcj9nqfu 150 11 beneficial beneficial JJ cord-006393-jcj9nqfu 150 12 effect effect NN cord-006393-jcj9nqfu 150 13 in in IN cord-006393-jcj9nqfu 150 14 the the DT cord-006393-jcj9nqfu 150 15 prevention prevention NN cord-006393-jcj9nqfu 150 16 of of IN cord-006393-jcj9nqfu 150 17 viral viral JJ cord-006393-jcj9nqfu 150 18 enteritis enteritis NN cord-006393-jcj9nqfu 150 19 and and CC cord-006393-jcj9nqfu 150 20 in in IN cord-006393-jcj9nqfu 150 21 counteracting counteract VBG cord-006393-jcj9nqfu 150 22 late late JJ cord-006393-jcj9nqfu 150 23 subclass subclass NN cord-006393-jcj9nqfu 150 24 deficiency deficiency NN cord-006393-jcj9nqfu 150 25 . . . cord-006393-jcj9nqfu 151 1 There there EX cord-006393-jcj9nqfu 151 2 may may MD cord-006393-jcj9nqfu 151 3 also also RB cord-006393-jcj9nqfu 151 4 be be VB cord-006393-jcj9nqfu 151 5 some some DT cord-006393-jcj9nqfu 151 6 modulating modulate VBG cord-006393-jcj9nqfu 151 7 influence influence NN cord-006393-jcj9nqfu 151 8 on on IN cord-006393-jcj9nqfu 151 9 the the DT cord-006393-jcj9nqfu 151 10 entire entire JJ cord-006393-jcj9nqfu 151 11 immunobiology immunobiology NN cord-006393-jcj9nqfu 151 12 of of IN cord-006393-jcj9nqfu 151 13 bone bone NN cord-006393-jcj9nqfu 151 14 marrow marrow NN cord-006393-jcj9nqfu 151 15 transplantation transplantation NN cord-006393-jcj9nqfu 151 16 . . . cord-006393-jcj9nqfu 152 1 Bone bone NN cord-006393-jcj9nqfu 152 2 marrow marrow NN cord-006393-jcj9nqfu 152 3 transplantation transplantation NN cord-006393-jcj9nqfu 152 4 for for IN cord-006393-jcj9nqfu 152 5 leukemia leukemia NN cord-006393-jcj9nqfu 152 6 following follow VBG cord-006393-jcj9nqfu 152 7 a a DT cord-006393-jcj9nqfu 152 8 new new JJ cord-006393-jcj9nqfu 152 9 busuIfan busuifan NN cord-006393-jcj9nqfu 152 10 and and CC cord-006393-jcj9nqfu 152 11 cyclophosphamide cyclophosphamide JJ cord-006393-jcj9nqfu 152 12 regimen regimen NN cord-006393-jcj9nqfu 152 13 Graft graft NN cord-006393-jcj9nqfu 152 14 versus versus IN cord-006393-jcj9nqfu 152 15 host host NN cord-006393-jcj9nqfu 152 16 disease disease NN cord-006393-jcj9nqfu 152 17 and and CC cord-006393-jcj9nqfu 152 18 survival survival NN cord-006393-jcj9nqfu 152 19 in in IN cord-006393-jcj9nqfu 152 20 patients patient NNS cord-006393-jcj9nqfu 152 21 with with IN cord-006393-jcj9nqfu 152 22 aplastic aplastic JJ cord-006393-jcj9nqfu 152 23 anemia anemia NN cord-006393-jcj9nqfu 152 24 treated treat VBN cord-006393-jcj9nqfu 152 25 by by IN cord-006393-jcj9nqfu 152 26 marrow marrow NN cord-006393-jcj9nqfu 152 27 grafts graft NNS cord-006393-jcj9nqfu 152 28 from from IN cord-006393-jcj9nqfu 152 29 HLA HLA NNP cord-006393-jcj9nqfu 152 30 - - HYPH cord-006393-jcj9nqfu 152 31 identical identical JJ cord-006393-jcj9nqfu 152 32 siblings sibling NNS cord-006393-jcj9nqfu 152 33 : : : cord-006393-jcj9nqfu 152 34 Beneficial beneficial JJ cord-006393-jcj9nqfu 152 35 effect effect NN cord-006393-jcj9nqfu 152 36 of of IN cord-006393-jcj9nqfu 152 37 a a DT cord-006393-jcj9nqfu 152 38 protective protective JJ cord-006393-jcj9nqfu 152 39 environment environment NN cord-006393-jcj9nqfu 152 40 Clinical clinical JJ cord-006393-jcj9nqfu 152 41 Use Use NNP cord-006393-jcj9nqfu 152 42 of of IN cord-006393-jcj9nqfu 152 43 Intravenous Intravenous NNP cord-006393-jcj9nqfu 152 44 Immunoglobulins Immunoglobulins NNP cord-006393-jcj9nqfu 152 45 Antibody Antibody NNP cord-006393-jcj9nqfu 152 46 therapy therapy NN cord-006393-jcj9nqfu 152 47 in in IN cord-006393-jcj9nqfu 152 48 gram gram JJ cord-006393-jcj9nqfu 152 49 - - HYPH cord-006393-jcj9nqfu 152 50 negative negative JJ cord-006393-jcj9nqfu 152 51 bacterial bacterial JJ cord-006393-jcj9nqfu 152 52 disease disease NN cord-006393-jcj9nqfu 153 1 The the DT cord-006393-jcj9nqfu 153 2 role role NN cord-006393-jcj9nqfu 153 3 of of IN cord-006393-jcj9nqfu 153 4 microflora microflora NN cord-006393-jcj9nqfu 153 5 in in IN cord-006393-jcj9nqfu 153 6 development development NN cord-006393-jcj9nqfu 153 7 of of IN cord-006393-jcj9nqfu 153 8 graft graft NN cord-006393-jcj9nqfu 153 9 versus versus IN cord-006393-jcj9nqfu 153 10 host host NN cord-006393-jcj9nqfu 153 11 disease disease NN cord-006393-jcj9nqfu 153 12 Graftvs Graftvs NNP cord-006393-jcj9nqfu 153 13 - - HYPH cord-006393-jcj9nqfu 153 14 host host NN cord-006393-jcj9nqfu 153 15 disease disease NN cord-006393-jcj9nqfu 153 16 and and CC cord-006393-jcj9nqfu 153 17 sialodacryoadenitis sialodacryoadenitis JJ cord-006393-jcj9nqfu 153 18 viral viral JJ cord-006393-jcj9nqfu 153 19 infection infection NN cord-006393-jcj9nqfu 153 20 in in IN cord-006393-jcj9nqfu 153 21 bone bone NN cord-006393-jcj9nqfu 153 22 marrow marrow NN cord-006393-jcj9nqfu 153 23 transplanted transplant VBD cord-006393-jcj9nqfu 153 24 rats rat NNS cord-006393-jcj9nqfu 153 25 Cytomegalovirus Cytomegalovirus NNP cord-006393-jcj9nqfu 153 26 ( ( -LRB- cord-006393-jcj9nqfu 153 27 CMV CMV NNP cord-006393-jcj9nqfu 153 28 ) ) -RRB- cord-006393-jcj9nqfu 153 29 infection infection NN cord-006393-jcj9nqfu 153 30 in in IN cord-006393-jcj9nqfu 153 31 bone bone NN cord-006393-jcj9nqfu 153 32 marrow marrow NN cord-006393-jcj9nqfu 153 33 transplant transplant NN cord-006393-jcj9nqfu 153 34 recipients recipient NNS cord-006393-jcj9nqfu 153 35 : : : cord-006393-jcj9nqfu 154 1 Use use NN cord-006393-jcj9nqfu 154 2 of of IN cord-006393-jcj9nqfu 154 3 intravenous intravenous JJ cord-006393-jcj9nqfu 154 4 gammaglobulin gammaglobulin NN cord-006393-jcj9nqfu 154 5 as as IN cord-006393-jcj9nqfu 154 6 prophylactic prophylactic JJ cord-006393-jcj9nqfu 154 7 and and CC cord-006393-jcj9nqfu 154 8 therapeutic therapeutic JJ cord-006393-jcj9nqfu 154 9 agents agent NNS cord-006393-jcj9nqfu 154 10 Successful successful JJ cord-006393-jcj9nqfu 154 11 treatment treatment NN cord-006393-jcj9nqfu 154 12 of of IN cord-006393-jcj9nqfu 154 13 serious serious JJ cord-006393-jcj9nqfu 154 14 cytomegalovirus cytomegalovirus NN cord-006393-jcj9nqfu 154 15 disease disease NN cord-006393-jcj9nqfu 154 16 with with IN cord-006393-jcj9nqfu 154 17 9(1,3-dihydroxy-2-propoxymethyl 9(1,3-dihydroxy-2-propoxymethyl CD cord-006393-jcj9nqfu 154 18 ) ) -RRB- cord-006393-jcj9nqfu 154 19 guanine guanine NN cord-006393-jcj9nqfu 154 20 in in IN cord-006393-jcj9nqfu 154 21 bone bone NN cord-006393-jcj9nqfu 154 22 marrow marrow NN cord-006393-jcj9nqfu 154 23 transplant transplant NN cord-006393-jcj9nqfu 154 24 ( ( -LRB- cord-006393-jcj9nqfu 154 25 BMT BMT NNP cord-006393-jcj9nqfu 154 26 ) ) -RRB- cord-006393-jcj9nqfu 154 27 patients patient NNS cord-006393-jcj9nqfu 155 1 The the DT cord-006393-jcj9nqfu 155 2 diagnostic diagnostic JJ cord-006393-jcj9nqfu 155 3 , , , cord-006393-jcj9nqfu 155 4 prophylactic prophylactic JJ cord-006393-jcj9nqfu 155 5 and and CC cord-006393-jcj9nqfu 155 6 therapeutic therapeutic JJ cord-006393-jcj9nqfu 155 7 uses use NNS cord-006393-jcj9nqfu 155 8 of of IN cord-006393-jcj9nqfu 155 9 monoclonal monoclonal JJ cord-006393-jcj9nqfu 155 10 antibodies antibody NNS cord-006393-jcj9nqfu 155 11 to to IN cord-006393-jcj9nqfu 155 12 human human JJ cord-006393-jcj9nqfu 155 13 cytomegalovirus cytomegalovirus NN cord-006393-jcj9nqfu 155 14 Infectious infectious JJ cord-006393-jcj9nqfu 155 15 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 155 16 in in IN cord-006393-jcj9nqfu 155 17 bone bone NN cord-006393-jcj9nqfu 155 18 marrow marrow NN cord-006393-jcj9nqfu 155 19 transplant transplant NN cord-006393-jcj9nqfu 155 20 recipients recipient NNS cord-006393-jcj9nqfu 155 21 Oral oral JJ cord-006393-jcj9nqfu 155 22 administration administration NN cord-006393-jcj9nqfu 155 23 of of IN cord-006393-jcj9nqfu 155 24 IgG IgG NNP cord-006393-jcj9nqfu 155 25 in in IN cord-006393-jcj9nqfu 155 26 marrow marrow NN cord-006393-jcj9nqfu 155 27 transplant transplant NN cord-006393-jcj9nqfu 155 28 recipients recipient NNS cord-006393-jcj9nqfu 155 29 Functional functional JJ cord-006393-jcj9nqfu 155 30 asplenia asplenia NN cord-006393-jcj9nqfu 155 31 in in IN cord-006393-jcj9nqfu 155 32 patients patient NNS cord-006393-jcj9nqfu 155 33 with with IN cord-006393-jcj9nqfu 155 34 chronic chronic JJ cord-006393-jcj9nqfu 155 35 graftversus graftversus NN cord-006393-jcj9nqfu 155 36 - - HYPH cord-006393-jcj9nqfu 155 37 host host NN cord-006393-jcj9nqfu 155 38 disease disease NN cord-006393-jcj9nqfu 155 39 : : : cord-006393-jcj9nqfu 155 40 Concise concise JJ cord-006393-jcj9nqfu 155 41 communication communication NN cord-006393-jcj9nqfu 155 42 IgG igg NN cord-006393-jcj9nqfu 155 43 subclass subclass NN cord-006393-jcj9nqfu 155 44 deficiency deficiency NN cord-006393-jcj9nqfu 155 45 and and CC cord-006393-jcj9nqfu 155 46 pneumococcal pneumococcal JJ cord-006393-jcj9nqfu 155 47 pneumonia pneumonia NN cord-006393-jcj9nqfu 155 48 following follow VBG cord-006393-jcj9nqfu 155 49 allogeneic allogeneic IN cord-006393-jcj9nqfu 155 50 marrow marrow NN cord-006393-jcj9nqfu 155 51 transplantation transplantation NN cord-006393-jcj9nqfu 155 52 Dr. Dr. NNP cord-006393-jcj9nqfu 155 53 Gulati Gulati NNP cord-006393-jcj9nqfu 155 54 : : : cord-006393-jcj9nqfu 155 55 What what WP cord-006393-jcj9nqfu 155 56 has have VBZ cord-006393-jcj9nqfu 155 57 been be VBN cord-006393-jcj9nqfu 155 58 your -PRON- PRP$ cord-006393-jcj9nqfu 155 59 experience experience NN cord-006393-jcj9nqfu 155 60 with with IN cord-006393-jcj9nqfu 155 61 autologous autologous JJ cord-006393-jcj9nqfu 155 62 transplants transplant NNS cord-006393-jcj9nqfu 155 63 ? ? . cord-006393-jcj9nqfu 156 1 Do do VBP cord-006393-jcj9nqfu 156 2 you -PRON- PRP cord-006393-jcj9nqfu 156 3 need need VB cord-006393-jcj9nqfu 156 4 to to TO cord-006393-jcj9nqfu 156 5 do do VB cord-006393-jcj9nqfu 156 6 all all PDT cord-006393-jcj9nqfu 156 7 this this DT cord-006393-jcj9nqfu 156 8 with with IN cord-006393-jcj9nqfu 156 9 patients patient NNS cord-006393-jcj9nqfu 156 10 who who WP cord-006393-jcj9nqfu 156 11 are be VBP cord-006393-jcj9nqfu 156 12 undergoing undergo VBG cord-006393-jcj9nqfu 156 13 autologous autologous JJ cord-006393-jcj9nqfu 156 14 transplants?Dr transplants?dr XX cord-006393-jcj9nqfu 156 15 . . . cord-006393-jcj9nqfu 157 1 Tutschka Tutschka NNP cord-006393-jcj9nqfu 157 2 : : : cord-006393-jcj9nqfu 158 1 I -PRON- PRP cord-006393-jcj9nqfu 158 2 do do VBP cord-006393-jcj9nqfu 158 3 not not RB cord-006393-jcj9nqfu 158 4 think think VB cord-006393-jcj9nqfu 158 5 so so RB cord-006393-jcj9nqfu 158 6 . . . cord-006393-jcj9nqfu 159 1 The the DT cord-006393-jcj9nqfu 159 2 incidence incidence NN cord-006393-jcj9nqfu 159 3 of of IN cord-006393-jcj9nqfu 159 4 interstitial interstitial JJ cord-006393-jcj9nqfu 159 5 pneumonia pneumonia NN cord-006393-jcj9nqfu 159 6 as as RB cord-006393-jcj9nqfu 159 7 well well RB cord-006393-jcj9nqfu 159 8 as as IN cord-006393-jcj9nqfu 159 9 hemorrhagic hemorrhagic JJ cord-006393-jcj9nqfu 159 10 gastroenteritis gastroenteritis NN cord-006393-jcj9nqfu 159 11 is be VBZ cord-006393-jcj9nqfu 159 12 much much RB cord-006393-jcj9nqfu 159 13 reduced reduce VBN cord-006393-jcj9nqfu 159 14 in in IN cord-006393-jcj9nqfu 159 15 autologous autologous JJ cord-006393-jcj9nqfu 159 16 transplants transplant NNS cord-006393-jcj9nqfu 159 17 - - : cord-006393-jcj9nqfu 159 18 perhaps perhaps RB cord-006393-jcj9nqfu 159 19 a a DT cord-006393-jcj9nqfu 159 20 quarter quarter NN cord-006393-jcj9nqfu 159 21 of of IN cord-006393-jcj9nqfu 159 22 that that DT cord-006393-jcj9nqfu 159 23 seen see VBN cord-006393-jcj9nqfu 159 24 in in IN cord-006393-jcj9nqfu 159 25 allogeneic allogeneic NN cord-006393-jcj9nqfu 159 26 transplants transplant NNS cord-006393-jcj9nqfu 159 27 . . . cord-006393-jcj9nqfu 160 1 Furthermore furthermore RB cord-006393-jcj9nqfu 160 2 , , , cord-006393-jcj9nqfu 160 3 the the DT cord-006393-jcj9nqfu 160 4 immune immune JJ cord-006393-jcj9nqfu 160 5 system system NN cord-006393-jcj9nqfu 160 6 recovers recover VBZ cord-006393-jcj9nqfu 160 7 much much RB cord-006393-jcj9nqfu 160 8 more more RBR cord-006393-jcj9nqfu 160 9 readily readily RB cord-006393-jcj9nqfu 160 10 after after IN cord-006393-jcj9nqfu 160 11 autologous autologous JJ cord-006393-jcj9nqfu 160 12 bone bone NN cord-006393-jcj9nqfu 160 13 marrow marrow NN cord-006393-jcj9nqfu 160 14 transplantation transplantation NN cord-006393-jcj9nqfu 160 15 . . . cord-006393-jcj9nqfu 161 1 On on IN cord-006393-jcj9nqfu 161 2 the the DT cord-006393-jcj9nqfu 161 3 other other JJ cord-006393-jcj9nqfu 161 4 hand hand NN cord-006393-jcj9nqfu 161 5 , , , cord-006393-jcj9nqfu 161 6 autologous autologous JJ cord-006393-jcj9nqfu 161 7 transplantation transplantation NN cord-006393-jcj9nqfu 161 8 patients patient NNS cord-006393-jcj9nqfu 161 9 might may MD cord-006393-jcj9nqfu 161 10 provide provide VB cord-006393-jcj9nqfu 161 11 an an DT cord-006393-jcj9nqfu 161 12 excellent excellent JJ cord-006393-jcj9nqfu 161 13 target target NN cord-006393-jcj9nqfu 161 14 population population NN cord-006393-jcj9nqfu 161 15 in in IN cord-006393-jcj9nqfu 161 16 which which WDT cord-006393-jcj9nqfu 161 17 to to TO cord-006393-jcj9nqfu 161 18 study study VB cord-006393-jcj9nqfu 161 19 more more RBR cord-006393-jcj9nqfu 161 20 nonspecific nonspecific JJ cord-006393-jcj9nqfu 161 21 effects effect NNS cord-006393-jcj9nqfu 161 22 , , , cord-006393-jcj9nqfu 161 23 such such JJ cord-006393-jcj9nqfu 161 24 as as IN cord-006393-jcj9nqfu 161 25 the the DT cord-006393-jcj9nqfu 161 26 reduction reduction NN cord-006393-jcj9nqfu 161 27 of of IN cord-006393-jcj9nqfu 161 28 infections infection NNS cord-006393-jcj9nqfu 161 29 during during IN cord-006393-jcj9nqfu 161 30 aplasia aplasia NNP cord-006393-jcj9nqfu 161 31 , , , cord-006393-jcj9nqfu 161 32 because because IN cord-006393-jcj9nqfu 161 33 we -PRON- PRP cord-006393-jcj9nqfu 161 34 do do VBP cord-006393-jcj9nqfu 161 35 not not RB cord-006393-jcj9nqfu 161 36 have have VB cord-006393-jcj9nqfu 161 37 the the DT cord-006393-jcj9nqfu 161 38 compounding compounding NN cord-006393-jcj9nqfu 161 39 variables variable NNS cord-006393-jcj9nqfu 161 40 of of IN cord-006393-jcj9nqfu 161 41 GVHD GVHD NNP cord-006393-jcj9nqfu 161 42 , , , cord-006393-jcj9nqfu 161 43 immune immune JJ cord-006393-jcj9nqfu 161 44 modulation modulation NN cord-006393-jcj9nqfu 161 45 phases phase NNS cord-006393-jcj9nqfu 161 46 , , , cord-006393-jcj9nqfu 161 47 and and CC cord-006393-jcj9nqfu 161 48 so so RB cord-006393-jcj9nqfu 161 49 on on RB cord-006393-jcj9nqfu 161 50 . . . cord-006393-jcj9nqfu 162 1 We -PRON- PRP cord-006393-jcj9nqfu 162 2 are be VBP cord-006393-jcj9nqfu 162 3 currently currently RB cord-006393-jcj9nqfu 162 4 not not RB cord-006393-jcj9nqfu 162 5 using use VBG cord-006393-jcj9nqfu 162 6 IVIG IVIG NNP cord-006393-jcj9nqfu 162 7 to to IN cord-006393-jcj9nqfu 162 8 the the DT cord-006393-jcj9nqfu 162 9 same same JJ cord-006393-jcj9nqfu 162 10 extent extent NN cord-006393-jcj9nqfu 162 11 in in IN cord-006393-jcj9nqfu 162 12 autologous autologous JJ cord-006393-jcj9nqfu 162 13 transplants transplant NNS cord-006393-jcj9nqfu 162 14 as as IN cord-006393-jcj9nqfu 162 15 we -PRON- PRP cord-006393-jcj9nqfu 162 16 do do VBP cord-006393-jcj9nqfu 162 17 in in IN cord-006393-jcj9nqfu 162 18 aUogeneic aUogeneic NNP cord-006393-jcj9nqfu 162 19 transplants transplant NNS cord-006393-jcj9nqfu 163 1 but but CC cord-006393-jcj9nqfu 163 2 I -PRON- PRP cord-006393-jcj9nqfu 163 3 think think VBP cord-006393-jcj9nqfu 163 4 it -PRON- PRP cord-006393-jcj9nqfu 163 5 is be VBZ cord-006393-jcj9nqfu 163 6 a a DT cord-006393-jcj9nqfu 163 7 good good JJ cord-006393-jcj9nqfu 163 8 study study NN cord-006393-jcj9nqfu 163 9 population population NN cord-006393-jcj9nqfu 163 10 . . .