id author title date pages extension mime words sentences flesch summary cache txt cord-303662-ro9879dl Wang, Fun-In Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated 1990-11-30 .txt text/plain 3778 213 48 Un-In view of the finding that whole body irradiairradiated mice demonstrated intense disease at tion at day 6 p.i. prevents JHMV-induced paraday 9 p.i. By contrast, mice given 850 rad at day 6 lytic-demyelinating disease, differential irradiation p.i. had few histological changes at day 9 p.i. In studies were conducted to determine whether critiaddition, a second mouse strain, BALB/cJ mice cal radiosensitive targets reside in the systemic or a Immune donor mice were 6-week-old C57BL/6J males given 106 PFU of JHMV 2.2-V-1 i.p. 6 days prior to transfer. These they resemble the original JHMV isolates, which experiments indicate that populations of murine in early passages primarily caused a nonfatal paradonor spleen cells, which are enriched for T lytic disease (Bailey et al., 1949; Cheever et al., lymphocytes and appear to be MHC-restricted, 1949) ; only after many i.c. passages did the virus restore demyelination to infected, irradiated re-acquire marked neurovirulence. ./cache/cord-303662-ro9879dl.txt ./txt/cord-303662-ro9879dl.txt