id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006393-jcj9nqfu	Tutschka, Peter J.	The use of immunoglobulin in bone marrow transplantation	1990		.txt	text/plain	3392	176	45	The role of bone marrow transplantation is to restore lymphohematopoietic function of a recipient whose marrow has been destroyed, either by disease or by the preparative therapy employed in an attempt to eradicate the patient's lymphohematopoietic malignancy. There are several risk factors for the development of interstitial pneumonia such as TBI (if the lung dose exceeds 600 rads), acute GVHD, increased age of the patient, CMV seropositivity of the patient before the transplant, transfusion of blood products from CMV-positive donors, inability to generate an antiviral cytotoxicity (which is very common in the postengraftment phase), and inability to mount a humoral antibody response. Investigators from UCLA, Minnesota, and Sloan-Kettering all showed, in reasonably well-controlled studies, that the incidence of CMV interstitial pneumonia was reduced in patients given high-titered antibody preparations compared to that in the control group. The low incidence of CMV interstitial pneumonia in this group indicated that IVIG might be effective in the CMV-seronegative patient even when receiving a seropositive donor graft.	./cache/cord-006393-jcj9nqfu.txt	./txt/cord-006393-jcj9nqfu.txt