Editorial Gerontology 2019;65:103–105 Pillars of Successful Research: Serendipity, Pasteur’s Axiom, Kairos, and Luck Published online: February 8, 2019 © 2019 S. Karger AG, Basel E-Mail karger@karger.com www.karger.com/ger DOI: 10.1159/000495861 For reasons I can only guess, I have apparently been a good teacher and mentor for many students and postdocs who later became highly successful scientists in many dif- ferent disciplines all over the world. In this Editorial, I will therefore try to discuss obvious and less salient circum- stances that impinge on the lives and professional achieve- ments of a scientist. Successful research depends on factors that are either inborn or acquired as well as spontaneously arising or consciously planned opportunities. Inborn prerequisites for successful scientific work include intellectual capacity – often restricted to a narrow scientific spectrum – pas- sion, original ideas, potential for lateral thinking, deter- mination for hard work (scientific results are based on 1% inspiration and 99% transpiration – Thomas A. Edison), and persistence. Constituents of a scientific career that can be planned to a certain extent are the choice of one’s specific research discipline or even special niche and the selection of an optimal working group or an institution led by a compe- tent mentor providing good and critical guidance through the jungle of your student days and your later indepen- dent life when you lead your own group or a larger enter- prise (do not forget that the best way to compete for a Nobel Prize is to first work in the laboratory of a Nobel laureate!). Finally, pure necessity in the course of a re- search project often leads to the development of new methods that are needed to overcome technical obstacles. In addition to these obvious ingredients of successful research, other, more ephemeral circumstances play es- sential roles. Some of these are intimately dependent on prior professional experience and therefore give prefer- ence to older scientists. For me, the most important rep- resentatives of these imponderabilities are Serendipity, Pasteur’s Axiom, Kairos, and, of course, pure luck. The term Serendipity is used in the English literature describing a finding that a person – in the present case a scientist – has originally not looked for. This notion was first coined by Horace Walpole, 4th Earl of Oxford (1717– 1797), alluding to an old Persian tale that described the adventures of the three princes of the land Serendip, the former island of Ceylon, now Sri Lanka. These princes swarmed out to their kingdom in disguise to look for typ- ical characteristics – wishes and achievements – of their people and were confronted continually with something different from their expectations. A telling example for a serendipitous finding is the dis- covery of America by Christoph Columbus or – more prosaic – that of the functional properties of Viagra. Ev- ery reader of this Editorial – including myself as its author – will certainly be able to cite numerous examples of ser- endipitous findings that occurred in the course of her/his own work and recall the surprise and satisfaction accom- panying this event. Equally important are discoveries based on Louis Pas- teur’s Axiom that “chance smiles at the prepared mind.” WickGerontology 2019;65:103–105104 DOI: 10.1159/000495861 In my own career, I was often confronted with unexpect- ed results from our own or other laboratories that I was able to interpret differently than my younger or less ex- perienced colleagues due to my longer and broader theo- retical and practical experiences. Thus, Serendipity and Pasteur’s Axiom are two no- tions that often contribute to the success of research de- pending on prior knowledge of a scientist. What about Kairos? Kairos has two meanings: on the one hand, it is the name of the ancient Greek god of the right moment or the right opportunity; on the other hand, it also denotes the right moment or opportunity itself that must not be missed because it will never arise again. The god Kairos is bald in front and wears a stack of hair on the back of his head (Fig.  1). Hence, a German proverb translated into English is “to seize an opportunity at its stack of hair.” In my own life as a group leader, teacher, and mentor, Kairos often meant the fortuitous gathering of exception- ally gifted young and older scientists at a certain period in our laboratory that created a unique collegial intellectual atmosphere, resulting in exceptional scientific moments and the beginning of many successful careers in different fields of research. All these considerations are, of course, not specific for research, but pertinent to all aspects of human life, and so is the least projectable, but most important facet – pure luck. For me, as the Editor-in-Chief of Gerontology, the year 2018 was again filled with pleasure and excitement upon the receipt of an ever-increasing number of interesting manuscripts for all sections. This was also the reason that we – together with the Editors for the topics Regeneration (Günter Lepperdinger) and Technology (Bijan Najafi) that so far were combined into one section – decided to run these as separate, independent sections starting in October 2018. One problem of being confronted with the increasing influx of so many manuscripts was their often purely de- scriptive nature. We have therefore added a sentence to our Mission Statement explaining that by definition, ger- ontology is interested in studies on mechanisms that pos- sibly underlie any described experimental, clinical, or other phenomenon. Furthermore, the Section Editors were instrumental in conveying the message to all authors that Gerontology is the only gerontological journal that addresses a very broad readership from many disciplines, requiring man- uscripts to be written in a style that can be understood by this diverse audience. As mentioned in my 2018 Editorial, the impact factor of Gerontology had risen above average for the year 2017. In 2018, a slight drop occurred due to the fact that our publishing house, Karger, had generously allowed us a significant increase of the number of pages for the evalu- ated period to work off our backload of accepted papers waiting in the pipeline. As every year, several members have rotated off our Editorial Board, and I would like to take this opportunity to thank them again for their intellectual input and dona- tion of time. Johannes Attems, Newcastle upon Tyne, UK, has to focus more intensively on a journal that he is editing and asked to be relieved from his duties as one of our three editors for the Clinical Section. He will, however, be fur- ther associated with Gerontology as a member of its Edito- rial Board. Peter Pietschmann, Vienna, Austria, an expe- rienced and highly competent member of our Editorial Board, will act as the new third Editor of the Clinical Sec- tion. Fig. 1. Agnostizi, Kairos-Relief von Lysippos, Kopie in Trogir, CC BY-SA 3.0. Pillars of Successful Research: Serendipity, Pasteur’s Axiom, Kairos, and Luck 105Gerontology 2019;65:103–105 DOI: 10.1159/000495861 David Gardiner, Irvine, CA, USA, has agreed to be- come the second editor for the new, independent Regen- erative Section, and Michael Schwenk, Heidelberg, Ger- many, will act as the second editor of the Technological Section. I am looking forward to our collaboration with great anticipation. Newly recruited members of the Editorial Board of Gerontology are Michael Beach, Marwan Sabbagh, and Timothy Farrell for the Clinical Section, and Dale Dan- nefer and Kira Birditt for the Behavioural Science Section. Thanks and Welcome! Finally, I would like to thank all Section Editors, mem- bers of the Editorial Board, reviewers, the staff of Karger – especially Mr. Nold, as the responsible representative for our journal – and Christine Süss from the Editorial office, for their ideas, dedication, and commitment to Gerontology during the year 2018! G. Wick, Innsbruck