id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_uxpl5a7yojcsvaj2kwr44hq3sq	Carolyn C. Woodroofe	Membrane-Permeable and -Impermeable Sensors of the Zinpyr Family and Their Application to Imaging of Hippocampal Zinc In Vivo	2004	8	.pdf	application/pdf	7023	775	72	(ZP1) is a fluorescein-based bright fluorescent sensor The synthesis of fluorescent sensors for biological imaging of Zn2+ has drawn a great deal of recent attention loosely bound zinc may be imaged in the brain: the cytosol, secretory storage granules including neuronal vesicles, and in the extracellular fluids. contains an ethyl ester to aid in solubilizing and retaining the sensor in cells, was designed and synthesized We previously communicated the analogous synthesis and properties of a ZP1-derivatized sensor containing an amido functional group at the 6 position [28]. the large fluorescence increase and that the dissociation constant for binding a second zinc(II) ion to ZP1 All four sensors have lower background fluorescence (f = 0.13–0.21) in the free state compared with tirred for an additional 4 hr, then evaporated under reduced presEnhanced Fluorescence Imaging of Hippocampal Zinc Fluorescent sensors for Zn2+ based on a fluorescein platform: synthesis, properties and intracellular distribution.	./cache/work_uxpl5a7yojcsvaj2kwr44hq3sq.pdf	./txt/work_uxpl5a7yojcsvaj2kwr44hq3sq.txt