id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_lc4bbuvctbdktlkdy35q5wzweu	Sonia Bertrand	Neuronal nAChR stereoselectivity to non-natural epibatidine derivatives	1999	7	.pdf	application/pdf	4223	437	67	Currents evoked by epibatidine and its derivatives on the major brain K4L2 nAChR. D : Dose-response relationships for (3)-epibatidine and methyl-(3)-epibatidine (mean of four cells, values are indicated in Table 1). Typical currents evoked, in a responsive oocyte, by acetylcholine (ACh), (+)-epibatidine and methyl-(+)-epibatidine are illustrated in Fig. 2A. Fig. 3A, the (+) enantiomers of epibatidine and methylepibatidine both evoked robust currents of comparable amplitude Sensitivity of the K7 nAChR to epibatidine and its methyl derivatives. PET images of [11C]N-methyl-(+)and (3)-epibatidine in rats. of the limited resolution of the PET images, only the total the brain activity curve is shown as % injected dose versus time in Fig. 6. Comparison of the PET images and the brain uptake curves showed interesting di¡erences in receptor binding properties of the methylated epibatidine stereoisomers. Sensitivity of epibatidine and derivatives to rat K4L2, K3L4 and K7 nAChRs	./cache/work_lc4bbuvctbdktlkdy35q5wzweu.pdf	./txt/work_lc4bbuvctbdktlkdy35q5wzweu.txt