id sid tid token lemma pos 10_1101-2021_01_06_425581 1 1 27015732 27015732 CD 10_1101-2021_01_06_425581 1 2 Periodicity periodicity NN 10_1101-2021_01_06_425581 1 3 in in IN 10_1101-2021_01_06_425581 1 4 the the DT 10_1101-2021_01_06_425581 1 5 embryo embryo NN 10_1101-2021_01_06_425581 1 6 : : : 10_1101-2021_01_06_425581 1 7 emergence emergence NN 10_1101-2021_01_06_425581 1 8 of of IN 10_1101-2021_01_06_425581 1 9 order order NN 10_1101-2021_01_06_425581 1 10 in in IN 10_1101-2021_01_06_425581 1 11 space space NN 10_1101-2021_01_06_425581 1 12 , , , 10_1101-2021_01_06_425581 1 13 diffusion diffusion NN 10_1101-2021_01_06_425581 1 14 of of IN 10_1101-2021_01_06_425581 1 15 order order NN 10_1101-2021_01_06_425581 1 16 in in IN 10_1101-2021_01_06_425581 1 17 time time NN 10_1101-2021_01_06_425581 1 18 Bradly bradly RB 10_1101-2021_01_06_425581 1 19 Alicea​1​,​2​ Alicea​1​,​2​ NNP 10_1101-2021_01_06_425581 1 20 , , , 10_1101-2021_01_06_425581 1 21 Ujjwal Ujjwal NNP 10_1101-2021_01_06_425581 1 22 Singh​1,​3 Singh​1,​3 NNP 10_1101-2021_01_06_425581 1 23 Keywords Keywords NNPS 10_1101-2021_01_06_425581 1 24 : : : 10_1101-2021_01_06_425581 1 25 Periodicity periodicity NN 10_1101-2021_01_06_425581 1 26 , , , 10_1101-2021_01_06_425581 1 27 Dynamical Dynamical NNP 10_1101-2021_01_06_425581 1 28 Systems Systems NNPS 10_1101-2021_01_06_425581 1 29 , , , 10_1101-2021_01_06_425581 1 30 ​C. ​c. ADD 10_1101-2021_01_06_425581 2 1 elegans​ elegans​ UH 10_1101-2021_01_06_425581 2 2 , , , 10_1101-2021_01_06_425581 2 3 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 2 4 , , , 10_1101-2021_01_06_425581 2 5 Developmental Developmental NNP 10_1101-2021_01_06_425581 2 6 Biology Biology NNP 10_1101-2021_01_06_425581 2 7 , , , 10_1101-2021_01_06_425581 2 8 Modeling Modeling NNP 10_1101-2021_01_06_425581 2 9 and and CC 10_1101-2021_01_06_425581 2 10 Simulation Simulation NNP 10_1101-2021_01_06_425581 2 11 Abstract Abstract NNP 10_1101-2021_01_06_425581 2 12 Does do VBZ 10_1101-2021_01_06_425581 2 13 embryonic embryonic JJ 10_1101-2021_01_06_425581 2 14 development development NN 10_1101-2021_01_06_425581 2 15 exhibit exhibit NN 10_1101-2021_01_06_425581 2 16 characteristic characteristic JJ 10_1101-2021_01_06_425581 2 17 temporal temporal JJ 10_1101-2021_01_06_425581 2 18 features feature NNS 10_1101-2021_01_06_425581 2 19 ? ? . 10_1101-2021_01_06_425581 3 1 This this DT 10_1101-2021_01_06_425581 3 2 is be VBZ 10_1101-2021_01_06_425581 3 3 quite quite RB 10_1101-2021_01_06_425581 3 4 apparent apparent JJ 10_1101-2021_01_06_425581 3 5 in in IN 10_1101-2021_01_06_425581 3 6 evolution evolution NN 10_1101-2021_01_06_425581 3 7 , , , 10_1101-2021_01_06_425581 3 8 where where WRB 10_1101-2021_01_06_425581 3 9 evolutionary evolutionary JJ 10_1101-2021_01_06_425581 3 10 change change NN 10_1101-2021_01_06_425581 3 11 has have VBZ 10_1101-2021_01_06_425581 3 12 been be VBN 10_1101-2021_01_06_425581 3 13 shown show VBN 10_1101-2021_01_06_425581 3 14 to to TO 10_1101-2021_01_06_425581 3 15 occur occur VB 10_1101-2021_01_06_425581 3 16 in in IN 10_1101-2021_01_06_425581 3 17 bursts burst NNS 10_1101-2021_01_06_425581 3 18 of of IN 10_1101-2021_01_06_425581 3 19 activity activity NN 10_1101-2021_01_06_425581 3 20 . . . 10_1101-2021_01_06_425581 4 1 Using use VBG 10_1101-2021_01_06_425581 4 2 two two CD 10_1101-2021_01_06_425581 4 3 animal animal NN 10_1101-2021_01_06_425581 4 4 models model NNS 10_1101-2021_01_06_425581 4 5 ( ( -LRB- 10_1101-2021_01_06_425581 4 6 Nematode Nematode NNP 10_1101-2021_01_06_425581 4 7 , , , 10_1101-2021_01_06_425581 4 8 ​Caenorhabditis ​caenorhabditis JJ 10_1101-2021_01_06_425581 4 9 elegans elegan NNS 10_1101-2021_01_06_425581 4 10 and and CC 10_1101-2021_01_06_425581 4 11 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 4 12 , , , 10_1101-2021_01_06_425581 4 13 ​Danio ​Danio NNP 10_1101-2021_01_06_425581 4 14 rerio​ rerio​ NNP 10_1101-2021_01_06_425581 4 15 ) ) -RRB- 10_1101-2021_01_06_425581 4 16 and and CC 10_1101-2021_01_06_425581 4 17 simulated simulate VBN 10_1101-2021_01_06_425581 4 18 data datum NNS 10_1101-2021_01_06_425581 4 19 , , , 10_1101-2021_01_06_425581 4 20 we -PRON- PRP 10_1101-2021_01_06_425581 4 21 demonstrate demonstrate VBP 10_1101-2021_01_06_425581 4 22 that that IN 10_1101-2021_01_06_425581 4 23 temporal temporal JJ 10_1101-2021_01_06_425581 4 24 heterogeneity heterogeneity NN 10_1101-2021_01_06_425581 4 25 exists exist VBZ 10_1101-2021_01_06_425581 4 26 in in IN 10_1101-2021_01_06_425581 4 27 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 4 28 at at IN 10_1101-2021_01_06_425581 4 29 the the DT 10_1101-2021_01_06_425581 4 30 cellular cellular JJ 10_1101-2021_01_06_425581 4 31 level level NN 10_1101-2021_01_06_425581 4 32 , , , 10_1101-2021_01_06_425581 4 33 and and CC 10_1101-2021_01_06_425581 4 34 may may MD 10_1101-2021_01_06_425581 4 35 have have VB 10_1101-2021_01_06_425581 4 36 functional functional JJ 10_1101-2021_01_06_425581 4 37 consequences consequence NNS 10_1101-2021_01_06_425581 4 38 . . . 10_1101-2021_01_06_425581 5 1 Cell cell NN 10_1101-2021_01_06_425581 5 2 proliferation proliferation NN 10_1101-2021_01_06_425581 5 3 and and CC 10_1101-2021_01_06_425581 5 4 division division NN 10_1101-2021_01_06_425581 5 5 from from IN 10_1101-2021_01_06_425581 5 6 cell cell NN 10_1101-2021_01_06_425581 5 7 tracking tracking NN 10_1101-2021_01_06_425581 5 8 data datum NNS 10_1101-2021_01_06_425581 5 9 is be VBZ 10_1101-2021_01_06_425581 5 10 subject subject JJ 10_1101-2021_01_06_425581 5 11 to to IN 10_1101-2021_01_06_425581 5 12 analysis analysis NN 10_1101-2021_01_06_425581 5 13 to to TO 10_1101-2021_01_06_425581 5 14 characterize characterize VB 10_1101-2021_01_06_425581 5 15 specific specific JJ 10_1101-2021_01_06_425581 5 16 features feature NNS 10_1101-2021_01_06_425581 5 17 in in IN 10_1101-2021_01_06_425581 5 18 each each DT 10_1101-2021_01_06_425581 5 19 model model NN 10_1101-2021_01_06_425581 5 20 species species NN 10_1101-2021_01_06_425581 5 21 . . . 10_1101-2021_01_06_425581 6 1 Simulated simulate VBN 10_1101-2021_01_06_425581 6 2 data data NN 10_1101-2021_01_06_425581 6 3 is be VBZ 10_1101-2021_01_06_425581 6 4 then then RB 10_1101-2021_01_06_425581 6 5 used use VBN 10_1101-2021_01_06_425581 6 6 to to TO 10_1101-2021_01_06_425581 6 7 understand understand VB 10_1101-2021_01_06_425581 6 8 what what WDT 10_1101-2021_01_06_425581 6 9 role role NN 10_1101-2021_01_06_425581 6 10 this this DT 10_1101-2021_01_06_425581 6 11 variation variation NN 10_1101-2021_01_06_425581 6 12 might may MD 10_1101-2021_01_06_425581 6 13 play play VB 10_1101-2021_01_06_425581 6 14 in in IN 10_1101-2021_01_06_425581 6 15 producing produce VBG 10_1101-2021_01_06_425581 6 16 phenotypic phenotypic NN 10_1101-2021_01_06_425581 6 17 variation variation NN 10_1101-2021_01_06_425581 6 18 in in IN 10_1101-2021_01_06_425581 6 19 the the DT 10_1101-2021_01_06_425581 6 20 adult adult NN 10_1101-2021_01_06_425581 6 21 phenotype phenotype NN 10_1101-2021_01_06_425581 6 22 . . . 10_1101-2021_01_06_425581 7 1 This this DT 10_1101-2021_01_06_425581 7 2 goes go VBZ 10_1101-2021_01_06_425581 7 3 beyond beyond IN 10_1101-2021_01_06_425581 7 4 a a DT 10_1101-2021_01_06_425581 7 5 molecular molecular JJ 10_1101-2021_01_06_425581 7 6 characterization characterization NN 10_1101-2021_01_06_425581 7 7 of of IN 10_1101-2021_01_06_425581 7 8 developmental developmental JJ 10_1101-2021_01_06_425581 7 9 regulation regulation NN 10_1101-2021_01_06_425581 7 10 to to TO 10_1101-2021_01_06_425581 7 11 provide provide VB 10_1101-2021_01_06_425581 7 12 a a DT 10_1101-2021_01_06_425581 7 13 quantitative quantitative JJ 10_1101-2021_01_06_425581 7 14 result result NN 10_1101-2021_01_06_425581 7 15 at at IN 10_1101-2021_01_06_425581 7 16 the the DT 10_1101-2021_01_06_425581 7 17 phenotypic phenotypic JJ 10_1101-2021_01_06_425581 7 18 scale scale NN 10_1101-2021_01_06_425581 7 19 of of IN 10_1101-2021_01_06_425581 7 20 complexity complexity NN 10_1101-2021_01_06_425581 7 21 . . . 10_1101-2021_01_06_425581 8 1 Introduction introduction NN 10_1101-2021_01_06_425581 8 2 While while IN 10_1101-2021_01_06_425581 8 3 the the DT 10_1101-2021_01_06_425581 8 4 case case NN 10_1101-2021_01_06_425581 8 5 for for IN 10_1101-2021_01_06_425581 8 6 the the DT 10_1101-2021_01_06_425581 8 7 effects effect NNS 10_1101-2021_01_06_425581 8 8 of of IN 10_1101-2021_01_06_425581 8 9 " " `` 10_1101-2021_01_06_425581 8 10 tempo tempo NN 10_1101-2021_01_06_425581 8 11 and and CC 10_1101-2021_01_06_425581 8 12 mode mode NN 10_1101-2021_01_06_425581 8 13 " " '' 10_1101-2021_01_06_425581 8 14 [ [ -LRB- 10_1101-2021_01_06_425581 8 15 1 1 CD 10_1101-2021_01_06_425581 8 16 ] ] -RRB- 10_1101-2021_01_06_425581 8 17 have have VBP 10_1101-2021_01_06_425581 8 18 been be VBN 10_1101-2021_01_06_425581 8 19 made make VBN 10_1101-2021_01_06_425581 8 20 for for IN 10_1101-2021_01_06_425581 8 21 the the DT 10_1101-2021_01_06_425581 8 22 evolutionary evolutionary JJ 10_1101-2021_01_06_425581 8 23 process process NN 10_1101-2021_01_06_425581 8 24 , , , 10_1101-2021_01_06_425581 8 25 a a DT 10_1101-2021_01_06_425581 8 26 similar similar JJ 10_1101-2021_01_06_425581 8 27 relationship relationship NN 10_1101-2021_01_06_425581 8 28 between between IN 10_1101-2021_01_06_425581 8 29 phenotypic phenotypic NN 10_1101-2021_01_06_425581 8 30 change change NN 10_1101-2021_01_06_425581 8 31 , , , 10_1101-2021_01_06_425581 8 32 time time NN 10_1101-2021_01_06_425581 8 33 , , , 10_1101-2021_01_06_425581 8 34 and and CC 10_1101-2021_01_06_425581 8 35 space space NN 10_1101-2021_01_06_425581 8 36 may may MD 10_1101-2021_01_06_425581 8 37 also also RB 10_1101-2021_01_06_425581 8 38 exist exist VB 10_1101-2021_01_06_425581 8 39 in in IN 10_1101-2021_01_06_425581 8 40 development development NN 10_1101-2021_01_06_425581 8 41 . . . 10_1101-2021_01_06_425581 9 1 One one CD 10_1101-2021_01_06_425581 9 2 obvious obvious JJ 10_1101-2021_01_06_425581 9 3 answer answer NN 10_1101-2021_01_06_425581 9 4 to to IN 10_1101-2021_01_06_425581 9 5 this this DT 10_1101-2021_01_06_425581 9 6 question question NN 10_1101-2021_01_06_425581 9 7 is be VBZ 10_1101-2021_01_06_425581 9 8 to to TO 10_1101-2021_01_06_425581 9 9 examine examine VB 10_1101-2021_01_06_425581 9 10 the the DT 10_1101-2021_01_06_425581 9 11 expression expression NN 10_1101-2021_01_06_425581 9 12 and and CC 10_1101-2021_01_06_425581 9 13 sequence sequence NN 10_1101-2021_01_06_425581 9 14 variation variation NN 10_1101-2021_01_06_425581 9 15 of of IN 10_1101-2021_01_06_425581 9 16 genes gene NNS 10_1101-2021_01_06_425581 9 17 associated associate VBN 10_1101-2021_01_06_425581 9 18 with with IN 10_1101-2021_01_06_425581 9 19 cell cell NN 10_1101-2021_01_06_425581 9 20 cycle cycle NN 10_1101-2021_01_06_425581 9 21 and and CC 10_1101-2021_01_06_425581 9 22 developmental developmental JJ 10_1101-2021_01_06_425581 9 23 patterning patterning NN 10_1101-2021_01_06_425581 9 24 [ [ -LRB- 10_1101-2021_01_06_425581 9 25 2 2 CD 10_1101-2021_01_06_425581 9 26 ] ] -RRB- 10_1101-2021_01_06_425581 9 27 . . . 10_1101-2021_01_06_425581 10 1 However however RB 10_1101-2021_01_06_425581 10 2 , , , 10_1101-2021_01_06_425581 10 3 there there EX 10_1101-2021_01_06_425581 10 4 is be VBZ 10_1101-2021_01_06_425581 10 5 a a DT 10_1101-2021_01_06_425581 10 6 potentially potentially RB 10_1101-2021_01_06_425581 10 7 more more RBR 10_1101-2021_01_06_425581 10 8 compelling compelling JJ 10_1101-2021_01_06_425581 10 9 top top RB 10_1101-2021_01_06_425581 10 10 - - HYPH 10_1101-2021_01_06_425581 10 11 down down NN 10_1101-2021_01_06_425581 10 12 explanation explanation NN 10_1101-2021_01_06_425581 10 13 . . . 10_1101-2021_01_06_425581 11 1 We -PRON- PRP 10_1101-2021_01_06_425581 11 2 will will MD 10_1101-2021_01_06_425581 11 3 use use VB 10_1101-2021_01_06_425581 11 4 two two CD 10_1101-2021_01_06_425581 11 5 model model NN 10_1101-2021_01_06_425581 11 6 organisms organism NNS 10_1101-2021_01_06_425581 11 7 to to TO 10_1101-2021_01_06_425581 11 8 demonstrate demonstrate VB 10_1101-2021_01_06_425581 11 9 how how WRB 10_1101-2021_01_06_425581 11 10 periodicity periodicity NN 10_1101-2021_01_06_425581 11 11 becomes become VBZ 10_1101-2021_01_06_425581 11 12 less less RBR 10_1101-2021_01_06_425581 11 13 synchronized synchronize VBN 10_1101-2021_01_06_425581 11 14 over over IN 10_1101-2021_01_06_425581 11 15 developmental developmental JJ 10_1101-2021_01_06_425581 11 16 time time NN 10_1101-2021_01_06_425581 11 17 and and CC 10_1101-2021_01_06_425581 11 18 space space NN 10_1101-2021_01_06_425581 11 19 . . . 10_1101-2021_01_06_425581 12 1 In in IN 10_1101-2021_01_06_425581 12 2 the the DT 10_1101-2021_01_06_425581 12 3 case case NN 10_1101-2021_01_06_425581 12 4 of of IN 10_1101-2021_01_06_425581 12 5 the the DT 10_1101-2021_01_06_425581 12 6 nematode nematode NNP 10_1101-2021_01_06_425581 12 7 ​Caenorhabditis ​Caenorhabditis NNP 10_1101-2021_01_06_425581 12 8 elegans elegans NNPS 10_1101-2021_01_06_425581 12 9 , , , 10_1101-2021_01_06_425581 12 10 a a DT 10_1101-2021_01_06_425581 12 11 comparison comparison NN 10_1101-2021_01_06_425581 12 12 of of IN 10_1101-2021_01_06_425581 12 13 embryogenetic embryogenetic JJ 10_1101-2021_01_06_425581 12 14 and and CC 10_1101-2021_01_06_425581 12 15 postembryonic postembryonic JJ 10_1101-2021_01_06_425581 12 16 cells cell NNS 10_1101-2021_01_06_425581 12 17 ( ( -LRB- 10_1101-2021_01_06_425581 12 18 developmental developmental JJ 10_1101-2021_01_06_425581 12 19 and and CC 10_1101-2021_01_06_425581 12 20 terminally terminally RB 10_1101-2021_01_06_425581 12 21 - - HYPH 10_1101-2021_01_06_425581 12 22 differentiated differentiate VBN 10_1101-2021_01_06_425581 12 23 cell cell NN 10_1101-2021_01_06_425581 12 24 birth birth NN 10_1101-2021_01_06_425581 12 25 times time NNS 10_1101-2021_01_06_425581 12 26 acquired acquire VBD 10_1101-2021_01_06_425581 12 27 from from IN 10_1101-2021_01_06_425581 12 28 [ [ -LRB- 10_1101-2021_01_06_425581 12 29 3 3 CD 10_1101-2021_01_06_425581 12 30 ] ] -RRB- 10_1101-2021_01_06_425581 12 31 ) ) -RRB- 10_1101-2021_01_06_425581 12 32 reveals reveal VBZ 10_1101-2021_01_06_425581 12 33 two two CD 10_1101-2021_01_06_425581 12 34 general general JJ 10_1101-2021_01_06_425581 12 35 patterns pattern NNS 10_1101-2021_01_06_425581 12 36 . . . 10_1101-2021_01_06_425581 13 1 For for IN 10_1101-2021_01_06_425581 13 2 the the DT 10_1101-2021_01_06_425581 13 3 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 13 4 ( ( -LRB- 10_1101-2021_01_06_425581 13 5 ​Danio ​Danio NNP 10_1101-2021_01_06_425581 13 6 rerio rerio NN 10_1101-2021_01_06_425581 13 7 ​ ​ NNP 10_1101-2021_01_06_425581 13 8 ) ) -RRB- 10_1101-2021_01_06_425581 13 9 , , , 10_1101-2021_01_06_425581 13 10 comparisons comparison NNS 10_1101-2021_01_06_425581 13 11 within within IN 10_1101-2021_01_06_425581 13 12 and and CC 10_1101-2021_01_06_425581 13 13 between between IN 10_1101-2021_01_06_425581 13 14 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 13 15 stages stage NNS 10_1101-2021_01_06_425581 13 16 based base VBN 10_1101-2021_01_06_425581 13 17 on on IN 10_1101-2021_01_06_425581 13 18 measurements measurement NNS 10_1101-2021_01_06_425581 13 19 of of IN 10_1101-2021_01_06_425581 13 20 cell cell NN 10_1101-2021_01_06_425581 13 21 nuclei nucleus NNS 10_1101-2021_01_06_425581 13 22 in in IN 10_1101-2021_01_06_425581 13 23 the the DT 10_1101-2021_01_06_425581 13 24 animal animal NN 10_1101-2021_01_06_425581 13 25 hemisphere hemisphere NN 10_1101-2021_01_06_425581 13 26 [ [ -LRB- 10_1101-2021_01_06_425581 13 27 4 4 LS 10_1101-2021_01_06_425581 13 28 ] ] -RRB- 10_1101-2021_01_06_425581 13 29 reveal reveal VB 10_1101-2021_01_06_425581 13 30 patterns pattern NNS 10_1101-2021_01_06_425581 13 31 at at IN 10_1101-2021_01_06_425581 13 32 multiple multiple JJ 10_1101-2021_01_06_425581 13 33 scales scale NNS 10_1101-2021_01_06_425581 13 34 . . . 10_1101-2021_01_06_425581 14 1 One one CD 10_1101-2021_01_06_425581 14 2 of of IN 10_1101-2021_01_06_425581 14 3 the the DT 10_1101-2021_01_06_425581 14 4 most most RBS 10_1101-2021_01_06_425581 14 5 notable notable JJ 10_1101-2021_01_06_425581 14 6 signatures signature NNS 10_1101-2021_01_06_425581 14 7 is be VBZ 10_1101-2021_01_06_425581 14 8 burstiness burstiness JJ 10_1101-2021_01_06_425581 14 9 [ [ -LRB- 10_1101-2021_01_06_425581 14 10 5 5 CD 10_1101-2021_01_06_425581 14 11 , , , 10_1101-2021_01_06_425581 14 12 6 6 CD 10_1101-2021_01_06_425581 14 13 ] ] -RRB- 10_1101-2021_01_06_425581 14 14 , , , 10_1101-2021_01_06_425581 14 15 or or CC 10_1101-2021_01_06_425581 14 16 a a DT 10_1101-2021_01_06_425581 14 17 large large JJ 10_1101-2021_01_06_425581 14 18 number number NN 10_1101-2021_01_06_425581 14 19 of of IN 10_1101-2021_01_06_425581 14 20 events event NNS 10_1101-2021_01_06_425581 14 21 occurring occur VBG 10_1101-2021_01_06_425581 14 22 in in IN 10_1101-2021_01_06_425581 14 23 a a DT 10_1101-2021_01_06_425581 14 24 short short JJ 10_1101-2021_01_06_425581 14 25 period period NN 10_1101-2021_01_06_425581 14 26 of of IN 10_1101-2021_01_06_425581 14 27 time time NN 10_1101-2021_01_06_425581 14 28 . . . 10_1101-2021_01_06_425581 15 1 These these DT 10_1101-2021_01_06_425581 15 2 bursts burst NNS 10_1101-2021_01_06_425581 15 3 can can MD 10_1101-2021_01_06_425581 15 4 either either CC 10_1101-2021_01_06_425581 15 5 be be VB 10_1101-2021_01_06_425581 15 6 periodic periodic JJ 10_1101-2021_01_06_425581 15 7 or or CC 10_1101-2021_01_06_425581 15 8 aperiodic aperiodic JJ 10_1101-2021_01_06_425581 15 9 , , , 10_1101-2021_01_06_425581 15 10 and and CC 10_1101-2021_01_06_425581 15 11 these these DT 10_1101-2021_01_06_425581 15 12 statistical statistical JJ 10_1101-2021_01_06_425581 15 13 features feature NNS 10_1101-2021_01_06_425581 15 14 define define VBP 10_1101-2021_01_06_425581 15 15 the the DT 10_1101-2021_01_06_425581 15 16 temporal temporal JJ 10_1101-2021_01_06_425581 15 17 nature nature NN 10_1101-2021_01_06_425581 15 18 of of IN 10_1101-2021_01_06_425581 15 19 development development NN 10_1101-2021_01_06_425581 15 20 , , , 10_1101-2021_01_06_425581 15 21 potentially potentially RB 10_1101-2021_01_06_425581 15 22 in in IN 10_1101-2021_01_06_425581 15 23 a a DT 10_1101-2021_01_06_425581 15 24 universal universal JJ 10_1101-2021_01_06_425581 15 25 manner manner NN 10_1101-2021_01_06_425581 15 26 across across IN 10_1101-2021_01_06_425581 15 27 species specie NNS 10_1101-2021_01_06_425581 15 28 . . . 10_1101-2021_01_06_425581 16 1 Based base VBN 10_1101-2021_01_06_425581 16 2 on on IN 10_1101-2021_01_06_425581 16 3 two two CD 10_1101-2021_01_06_425581 16 4 species specie NNS 10_1101-2021_01_06_425581 16 5 and and CC 10_1101-2021_01_06_425581 16 6 a a DT 10_1101-2021_01_06_425581 16 7 computational computational JJ 10_1101-2021_01_06_425581 16 8 model model NN 10_1101-2021_01_06_425581 16 9 , , , 10_1101-2021_01_06_425581 16 10 we -PRON- PRP 10_1101-2021_01_06_425581 16 11 predict predict VBP 10_1101-2021_01_06_425581 16 12 that that IN 10_1101-2021_01_06_425581 16 13 periodic periodic JJ 10_1101-2021_01_06_425581 16 14 changes change NNS 10_1101-2021_01_06_425581 16 15 in in IN 10_1101-2021_01_06_425581 16 16 the the DT 10_1101-2021_01_06_425581 16 17 frequency frequency NN 10_1101-2021_01_06_425581 16 18 of of IN 10_1101-2021_01_06_425581 16 19 new new JJ 10_1101-2021_01_06_425581 16 20 cells cell NNS 10_1101-2021_01_06_425581 16 21 over over IN 10_1101-2021_01_06_425581 16 22 developmental developmental JJ 10_1101-2021_01_06_425581 16 23 time time NN 10_1101-2021_01_06_425581 16 24 represents represent VBZ 10_1101-2021_01_06_425581 16 25 cell cell NN 10_1101-2021_01_06_425581 16 26 proliferation proliferation NN 10_1101-2021_01_06_425581 16 27 without without IN 10_1101-2021_01_06_425581 16 28 functional functional JJ 10_1101-2021_01_06_425581 16 29 distinction distinction NN 10_1101-2021_01_06_425581 16 30 . . . 10_1101-2021_01_06_425581 17 1 We -PRON- PRP 10_1101-2021_01_06_425581 17 2 also also RB 10_1101-2021_01_06_425581 17 3 analyze analyze VBP 10_1101-2021_01_06_425581 17 4 the the DT 10_1101-2021_01_06_425581 17 5 intervals interval NNS 10_1101-2021_01_06_425581 17 6 between between IN 10_1101-2021_01_06_425581 17 7 bursts burst NNS 10_1101-2021_01_06_425581 17 8 in in IN 10_1101-2021_01_06_425581 17 9 cell cell NN 10_1101-2021_01_06_425581 17 10 division division NN 10_1101-2021_01_06_425581 17 11 ( ( -LRB- 10_1101-2021_01_06_425581 17 12 and and CC 10_1101-2021_01_06_425581 17 13 cell cell NN 10_1101-2021_01_06_425581 17 14 differentiation differentiation NN 10_1101-2021_01_06_425581 17 15 in in IN 10_1101-2021_01_06_425581 17 16 the the DT 10_1101-2021_01_06_425581 17 17 case case NN 10_1101-2021_01_06_425581 17 18 of of IN 10_1101-2021_01_06_425581 17 19 ​C. ​C. NNP 10_1101-2021_01_06_425581 18 1 elegans elegans NNPS 10_1101-2021_01_06_425581 18 2 ​ ​ NNP 10_1101-2021_01_06_425581 18 3 ) ) -RRB- 10_1101-2021_01_06_425581 18 4 . . . 10_1101-2021_01_06_425581 19 1 These these DT 10_1101-2021_01_06_425581 19 2 bursts burst NNS 10_1101-2021_01_06_425581 19 3 are be VBP 10_1101-2021_01_06_425581 19 4 derived derive VBN 10_1101-2021_01_06_425581 19 5 from from IN 10_1101-2021_01_06_425581 19 6 both both DT 10_1101-2021_01_06_425581 19 7 time time NN 10_1101-2021_01_06_425581 19 8 - - HYPH 10_1101-2021_01_06_425581 19 9 series series NN 10_1101-2021_01_06_425581 19 10 segmentation segmentation NN 10_1101-2021_01_06_425581 19 11 and and CC 10_1101-2021_01_06_425581 19 12 decomposition decomposition NN 10_1101-2021_01_06_425581 19 13 in in IN 10_1101-2021_01_06_425581 19 14 the the DT 10_1101-2021_01_06_425581 19 15 frequency frequency NN 10_1101-2021_01_06_425581 19 16 domain domain NN 10_1101-2021_01_06_425581 19 17 . . . 10_1101-2021_01_06_425581 20 1 We -PRON- PRP 10_1101-2021_01_06_425581 20 2 show show VBP 10_1101-2021_01_06_425581 20 3 that that IN 10_1101-2021_01_06_425581 20 4 these these DT 10_1101-2021_01_06_425581 20 5 results result NNS 10_1101-2021_01_06_425581 20 6 consistently consistently RB 10_1101-2021_01_06_425581 20 7 point point VBP 10_1101-2021_01_06_425581 20 8 to to IN 10_1101-2021_01_06_425581 20 9 great great JJ 10_1101-2021_01_06_425581 20 10 temporal temporal JJ 10_1101-2021_01_06_425581 20 11 variation variation NN 10_1101-2021_01_06_425581 20 12 at at IN 10_1101-2021_01_06_425581 20 13 the the DT 10_1101-2021_01_06_425581 20 14 cellular cellular JJ 10_1101-2021_01_06_425581 20 15 level level NN 10_1101-2021_01_06_425581 20 16 , , , 10_1101-2021_01_06_425581 20 17 and and CC 10_1101-2021_01_06_425581 20 18 may may MD 10_1101-2021_01_06_425581 20 19 play play VB 10_1101-2021_01_06_425581 20 20 a a DT 10_1101-2021_01_06_425581 20 21 role role NN 10_1101-2021_01_06_425581 20 22 in in IN 10_1101-2021_01_06_425581 20 23 shaping shape VBG 10_1101-2021_01_06_425581 20 24 morphogenesis morphogenesis NN 10_1101-2021_01_06_425581 20 25 . . . 10_1101-2021_01_06_425581 21 1 In in IN 10_1101-2021_01_06_425581 21 2 addition addition NN 10_1101-2021_01_06_425581 21 3 , , , 10_1101-2021_01_06_425581 21 4 these these DT 10_1101-2021_01_06_425581 21 5 1 1 CD 10_1101-2021_01_06_425581 21 6 ​OpenWorm ​openworm CD 10_1101-2021_01_06_425581 21 7 Foundation Foundation NNP 10_1101-2021_01_06_425581 21 8 , , , 10_1101-2021_01_06_425581 21 9 Boston Boston NNP 10_1101-2021_01_06_425581 21 10 , , , 10_1101-2021_01_06_425581 21 11 MA MA NNP 10_1101-2021_01_06_425581 21 12 USA USA NNP 10_1101-2021_01_06_425581 21 13 . . . 10_1101-2021_01_06_425581 22 1 ​balicea@openworm.org ​balicea@openworm.org NNP 10_1101-2021_01_06_425581 22 2 2 2 CD 10_1101-2021_01_06_425581 22 3 ​Orthogonal ​Orthogonal NNP 10_1101-2021_01_06_425581 22 4 Research Research NNP 10_1101-2021_01_06_425581 22 5 and and CC 10_1101-2021_01_06_425581 22 6 Education Education NNP 10_1101-2021_01_06_425581 22 7 Laboratory Laboratory NNP 10_1101-2021_01_06_425581 22 8 , , , 10_1101-2021_01_06_425581 22 9 Champaign Champaign NNP 10_1101-2021_01_06_425581 22 10 , , , 10_1101-2021_01_06_425581 22 11 IL IL NNP 10_1101-2021_01_06_425581 22 12 USA USA NNP 10_1101-2021_01_06_425581 22 13 . . . 10_1101-2021_01_06_425581 23 1 3 3 LS 10_1101-2021_01_06_425581 23 2 ​IIIT ​iiit NN 10_1101-2021_01_06_425581 23 3 Delhi Delhi NNP 10_1101-2021_01_06_425581 23 4 , , , 10_1101-2021_01_06_425581 23 5 Delhi Delhi NNP 10_1101-2021_01_06_425581 23 6 , , , 10_1101-2021_01_06_425581 23 7 India India NNP 10_1101-2021_01_06_425581 23 8 . . . 10_1101-2021_01_06_425581 24 1 .CC .CC NFP 10_1101-2021_01_06_425581 24 2 - - : 10_1101-2021_01_06_425581 24 3 BY BY NNP 10_1101-2021_01_06_425581 24 4 - - HYPH 10_1101-2021_01_06_425581 24 5 NC NC NNP 10_1101-2021_01_06_425581 24 6 4.0 4.0 CD 10_1101-2021_01_06_425581 24 7 International international JJ 10_1101-2021_01_06_425581 24 8 licensemade licensemade NN 10_1101-2021_01_06_425581 24 9 available available JJ 10_1101-2021_01_06_425581 24 10 under under IN 10_1101-2021_01_06_425581 24 11 a a DT 10_1101-2021_01_06_425581 24 12 ( ( -LRB- 10_1101-2021_01_06_425581 24 13 which which WDT 10_1101-2021_01_06_425581 24 14 was be VBD 10_1101-2021_01_06_425581 24 15 not not RB 10_1101-2021_01_06_425581 24 16 certified certify VBN 10_1101-2021_01_06_425581 24 17 by by IN 10_1101-2021_01_06_425581 24 18 peer peer NN 10_1101-2021_01_06_425581 24 19 review review NN 10_1101-2021_01_06_425581 24 20 ) ) -RRB- 10_1101-2021_01_06_425581 24 21 is be VBZ 10_1101-2021_01_06_425581 24 22 the the DT 10_1101-2021_01_06_425581 24 23 author author NN 10_1101-2021_01_06_425581 24 24 / / SYM 10_1101-2021_01_06_425581 24 25 funder funder NN 10_1101-2021_01_06_425581 24 26 , , , 10_1101-2021_01_06_425581 24 27 who who WP 10_1101-2021_01_06_425581 24 28 has have VBZ 10_1101-2021_01_06_425581 24 29 granted grant VBN 10_1101-2021_01_06_425581 24 30 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 24 31 a a DT 10_1101-2021_01_06_425581 24 32 license license NN 10_1101-2021_01_06_425581 24 33 to to TO 10_1101-2021_01_06_425581 24 34 display display VB 10_1101-2021_01_06_425581 24 35 the the DT 10_1101-2021_01_06_425581 24 36 preprint preprint NN 10_1101-2021_01_06_425581 24 37 in in IN 10_1101-2021_01_06_425581 24 38 perpetuity perpetuity NN 10_1101-2021_01_06_425581 24 39 . . . 10_1101-2021_01_06_425581 25 1 It -PRON- PRP 10_1101-2021_01_06_425581 25 2 is be VBZ 10_1101-2021_01_06_425581 25 3 The the DT 10_1101-2021_01_06_425581 25 4 copyright copyright NN 10_1101-2021_01_06_425581 25 5 holder holder NN 10_1101-2021_01_06_425581 25 6 for for IN 10_1101-2021_01_06_425581 25 7 this this DT 10_1101-2021_01_06_425581 25 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 25 9 version version NN 10_1101-2021_01_06_425581 25 10 posted post VBD 10_1101-2021_01_06_425581 25 11 January January NNP 10_1101-2021_01_06_425581 25 12 8 8 CD 10_1101-2021_01_06_425581 25 13 , , , 10_1101-2021_01_06_425581 25 14 2021 2021 CD 10_1101-2021_01_06_425581 25 15 . . . 10_1101-2021_01_06_425581 25 16 ; ; : 10_1101-2021_01_06_425581 25 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 25 18 : : : 10_1101-2021_01_06_425581 25 19 bioRxiv biorxiv VB 10_1101-2021_01_06_425581 25 20 preprint preprint NN 10_1101-2021_01_06_425581 25 21 mailto:balicea@openworm.org mailto:balicea@openworm.org NN 10_1101-2021_01_06_425581 25 22 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 25 23 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 25 24 changes change NNS 10_1101-2021_01_06_425581 25 25 in in IN 10_1101-2021_01_06_425581 25 26 frequency frequency NN 10_1101-2021_01_06_425581 25 27 and and CC 10_1101-2021_01_06_425581 25 28 periodicity periodicity NN 10_1101-2021_01_06_425581 25 29 over over IN 10_1101-2021_01_06_425581 25 30 time time NN 10_1101-2021_01_06_425581 25 31 results result NNS 10_1101-2021_01_06_425581 25 32 in in IN 10_1101-2021_01_06_425581 25 33 spatial spatial JJ 10_1101-2021_01_06_425581 25 34 variation variation NN 10_1101-2021_01_06_425581 25 35 ( ( -LRB- 10_1101-2021_01_06_425581 25 36 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 25 37 Figure Figure NNP 10_1101-2021_01_06_425581 25 38 1 1 CD 10_1101-2021_01_06_425581 25 39 ) ) -RRB- 10_1101-2021_01_06_425581 25 40 . . . 10_1101-2021_01_06_425581 26 1 To to TO 10_1101-2021_01_06_425581 26 2 characterize characterize VB 10_1101-2021_01_06_425581 26 3 spatial spatial JJ 10_1101-2021_01_06_425581 26 4 variation variation NN 10_1101-2021_01_06_425581 26 5 , , , 10_1101-2021_01_06_425581 26 6 we -PRON- PRP 10_1101-2021_01_06_425581 26 7 utilize utilize VBP 10_1101-2021_01_06_425581 26 8 embryo embryo NN 10_1101-2021_01_06_425581 26 9 networks network NNS 10_1101-2021_01_06_425581 26 10 [ [ -LRB- 10_1101-2021_01_06_425581 26 11 7 7 CD 10_1101-2021_01_06_425581 26 12 ] ] -RRB- 10_1101-2021_01_06_425581 26 13 . . . 10_1101-2021_01_06_425581 27 1 Embryo embryo NN 10_1101-2021_01_06_425581 27 2 networks network NNS 10_1101-2021_01_06_425581 27 3 are be VBP 10_1101-2021_01_06_425581 27 4 complex complex JJ 10_1101-2021_01_06_425581 27 5 networks network NNS 10_1101-2021_01_06_425581 27 6 based base VBN 10_1101-2021_01_06_425581 27 7 on on IN 10_1101-2021_01_06_425581 27 8 the the DT 10_1101-2021_01_06_425581 27 9 relative relative JJ 10_1101-2021_01_06_425581 27 10 proximity proximity NN 10_1101-2021_01_06_425581 27 11 of of IN 10_1101-2021_01_06_425581 27 12 cells cell NNS 10_1101-2021_01_06_425581 27 13 as as IN 10_1101-2021_01_06_425581 27 14 they -PRON- PRP 10_1101-2021_01_06_425581 27 15 divide divide VBP 10_1101-2021_01_06_425581 27 16 and and CC 10_1101-2021_01_06_425581 27 17 migrate migrate VBP 10_1101-2021_01_06_425581 27 18 during during IN 10_1101-2021_01_06_425581 27 19 the the DT 10_1101-2021_01_06_425581 27 20 developmental developmental JJ 10_1101-2021_01_06_425581 27 21 process process NN 10_1101-2021_01_06_425581 27 22 . . . 10_1101-2021_01_06_425581 28 1 The the DT 10_1101-2021_01_06_425581 28 2 resulting result VBG 10_1101-2021_01_06_425581 28 3 network network NN 10_1101-2021_01_06_425581 28 4 topologies topology NNS 10_1101-2021_01_06_425581 28 5 provide provide VBP 10_1101-2021_01_06_425581 28 6 not not RB 10_1101-2021_01_06_425581 28 7 only only JJ 10_1101-2021_01_06_425581 28 8 information information NN 10_1101-2021_01_06_425581 28 9 about about IN 10_1101-2021_01_06_425581 28 10 spatial spatial JJ 10_1101-2021_01_06_425581 28 11 variation variation NN 10_1101-2021_01_06_425581 28 12 , , , 10_1101-2021_01_06_425581 28 13 but but CC 10_1101-2021_01_06_425581 28 14 cellular cellular JJ 10_1101-2021_01_06_425581 28 15 interactions interaction NNS 10_1101-2021_01_06_425581 28 16 and and CC 10_1101-2021_01_06_425581 28 17 other other JJ 10_1101-2021_01_06_425581 28 18 signaling signaling NN 10_1101-2021_01_06_425581 28 19 connections connection NNS 10_1101-2021_01_06_425581 28 20 as as RB 10_1101-2021_01_06_425581 28 21 well well RB 10_1101-2021_01_06_425581 28 22 [ [ -LRB- 10_1101-2021_01_06_425581 28 23 8 8 CD 10_1101-2021_01_06_425581 28 24 , , , 10_1101-2021_01_06_425581 28 25 9 9 CD 10_1101-2021_01_06_425581 28 26 ] ] -RRB- 10_1101-2021_01_06_425581 28 27 . . . 10_1101-2021_01_06_425581 29 1 The the DT 10_1101-2021_01_06_425581 29 2 existence existence NN 10_1101-2021_01_06_425581 29 3 of of IN 10_1101-2021_01_06_425581 29 4 network network NN 10_1101-2021_01_06_425581 29 5 structure structure NN 10_1101-2021_01_06_425581 29 6 in in IN 10_1101-2021_01_06_425581 29 7 the the DT 10_1101-2021_01_06_425581 29 8 form form NN 10_1101-2021_01_06_425581 29 9 of of IN 10_1101-2021_01_06_425581 29 10 modules module NNS 10_1101-2021_01_06_425581 29 11 or or CC 10_1101-2021_01_06_425581 29 12 regions region NNS 10_1101-2021_01_06_425581 29 13 of of IN 10_1101-2021_01_06_425581 29 14 dense dense JJ 10_1101-2021_01_06_425581 29 15 connectivity connectivity NN 10_1101-2021_01_06_425581 29 16 can can MD 10_1101-2021_01_06_425581 29 17 reveal reveal VB 10_1101-2021_01_06_425581 29 18 a a DT 10_1101-2021_01_06_425581 29 19 great great JJ 10_1101-2021_01_06_425581 29 20 deal deal NN 10_1101-2021_01_06_425581 29 21 about about IN 10_1101-2021_01_06_425581 29 22 the the DT 10_1101-2021_01_06_425581 29 23 unfolding unfolding NN 10_1101-2021_01_06_425581 29 24 of of IN 10_1101-2021_01_06_425581 29 25 lineage lineage NN 10_1101-2021_01_06_425581 29 26 trees tree NNS 10_1101-2021_01_06_425581 29 27 in in IN 10_1101-2021_01_06_425581 29 28 time time NN 10_1101-2021_01_06_425581 29 29 . . . 10_1101-2021_01_06_425581 30 1 Returning return VBG 10_1101-2021_01_06_425581 30 2 to to IN 10_1101-2021_01_06_425581 30 3 the the DT 10_1101-2021_01_06_425581 30 4 first first JJ 10_1101-2021_01_06_425581 30 5 prediction prediction NN 10_1101-2021_01_06_425581 30 6 , , , 10_1101-2021_01_06_425581 30 7 we -PRON- PRP 10_1101-2021_01_06_425581 30 8 can can MD 10_1101-2021_01_06_425581 30 9 create create VB 10_1101-2021_01_06_425581 30 10 computational computational JJ 10_1101-2021_01_06_425581 30 11 summaries summary NNS 10_1101-2021_01_06_425581 30 12 of of IN 10_1101-2021_01_06_425581 30 13 cell cell NN 10_1101-2021_01_06_425581 30 14 division division NN 10_1101-2021_01_06_425581 30 15 events event NNS 10_1101-2021_01_06_425581 30 16 called call VBD 10_1101-2021_01_06_425581 30 17 numeric numeric JJ 10_1101-2021_01_06_425581 30 18 embryos embryo NNS 10_1101-2021_01_06_425581 30 19 to to TO 10_1101-2021_01_06_425581 30 20 model model VB 10_1101-2021_01_06_425581 30 21 the the DT 10_1101-2021_01_06_425581 30 22 proliferation proliferation NN 10_1101-2021_01_06_425581 30 23 of of IN 10_1101-2021_01_06_425581 30 24 cells cell NNS 10_1101-2021_01_06_425581 30 25 over over IN 10_1101-2021_01_06_425581 30 26 time time NN 10_1101-2021_01_06_425581 30 27 . . . 10_1101-2021_01_06_425581 31 1 We -PRON- PRP 10_1101-2021_01_06_425581 31 2 call call VBP 10_1101-2021_01_06_425581 31 3 these these DT 10_1101-2021_01_06_425581 31 4 computational computational JJ 10_1101-2021_01_06_425581 31 5 models model NNS 10_1101-2021_01_06_425581 31 6 , , , 10_1101-2021_01_06_425581 31 7 numeric numeric JJ 10_1101-2021_01_06_425581 31 8 embryos embryo NNS 10_1101-2021_01_06_425581 31 9 , , , 10_1101-2021_01_06_425581 31 10 and and CC 10_1101-2021_01_06_425581 31 11 can can MD 10_1101-2021_01_06_425581 31 12 be be VB 10_1101-2021_01_06_425581 31 13 used use VBN 10_1101-2021_01_06_425581 31 14 to to TO 10_1101-2021_01_06_425581 31 15 model model VB 10_1101-2021_01_06_425581 31 16 branching branch VBG 10_1101-2021_01_06_425581 31 17 events event NNS 10_1101-2021_01_06_425581 31 18 in in IN 10_1101-2021_01_06_425581 31 19 a a DT 10_1101-2021_01_06_425581 31 20 lineage lineage NN 10_1101-2021_01_06_425581 31 21 tree tree NN 10_1101-2021_01_06_425581 31 22 . . . 10_1101-2021_01_06_425581 32 1 Numeric numeric JJ 10_1101-2021_01_06_425581 32 2 embryos embryo NNS 10_1101-2021_01_06_425581 32 3 can can MD 10_1101-2021_01_06_425581 32 4 be be VB 10_1101-2021_01_06_425581 32 5 used use VBN 10_1101-2021_01_06_425581 32 6 to to TO 10_1101-2021_01_06_425581 32 7 model model VB 10_1101-2021_01_06_425581 32 8 the the DT 10_1101-2021_01_06_425581 32 9 distribution distribution NN 10_1101-2021_01_06_425581 32 10 of of IN 10_1101-2021_01_06_425581 32 11 branching branch VBG 10_1101-2021_01_06_425581 32 12 events event NNS 10_1101-2021_01_06_425581 32 13 in in IN 10_1101-2021_01_06_425581 32 14 time time NN 10_1101-2021_01_06_425581 32 15 , , , 10_1101-2021_01_06_425581 32 16 independent independent JJ 10_1101-2021_01_06_425581 32 17 of of IN 10_1101-2021_01_06_425581 32 18 cell cell NN 10_1101-2021_01_06_425581 32 19 identity identity NN 10_1101-2021_01_06_425581 32 20 or or CC 10_1101-2021_01_06_425581 32 21 spatial spatial JJ 10_1101-2021_01_06_425581 32 22 context context NN 10_1101-2021_01_06_425581 32 23 . . . 10_1101-2021_01_06_425581 33 1 Approximating approximate VBG 10_1101-2021_01_06_425581 33 2 this this DT 10_1101-2021_01_06_425581 33 3 distribution distribution NN 10_1101-2021_01_06_425581 33 4 provides provide VBZ 10_1101-2021_01_06_425581 33 5 us -PRON- PRP 10_1101-2021_01_06_425581 33 6 with with IN 10_1101-2021_01_06_425581 33 7 a a DT 10_1101-2021_01_06_425581 33 8 periodic periodic JJ 10_1101-2021_01_06_425581 33 9 time time NN 10_1101-2021_01_06_425581 33 10 - - HYPH 10_1101-2021_01_06_425581 33 11 series series NN 10_1101-2021_01_06_425581 33 12 that that WDT 10_1101-2021_01_06_425581 33 13 tells tell VBZ 10_1101-2021_01_06_425581 33 14 us -PRON- PRP 10_1101-2021_01_06_425581 33 15 something something NN 10_1101-2021_01_06_425581 33 16 about about IN 10_1101-2021_01_06_425581 33 17 the the DT 10_1101-2021_01_06_425581 33 18 speed speed NN 10_1101-2021_01_06_425581 33 19 of of IN 10_1101-2021_01_06_425581 33 20 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 33 21 : : : 10_1101-2021_01_06_425581 33 22 how how WRB 10_1101-2021_01_06_425581 33 23 quickly quickly RB 10_1101-2021_01_06_425581 33 24 can can MD 10_1101-2021_01_06_425581 33 25 different different JJ 10_1101-2021_01_06_425581 33 26 underlying underlying JJ 10_1101-2021_01_06_425581 33 27 distributions distribution NNS 10_1101-2021_01_06_425581 33 28 of of IN 10_1101-2021_01_06_425581 33 29 cell cell NN 10_1101-2021_01_06_425581 33 30 division division NN 10_1101-2021_01_06_425581 33 31 produce produce VBP 10_1101-2021_01_06_425581 33 32 a a DT 10_1101-2021_01_06_425581 33 33 phenotype phenotype NN 10_1101-2021_01_06_425581 33 34 with with IN 10_1101-2021_01_06_425581 33 35 many many JJ 10_1101-2021_01_06_425581 33 36 undifferentiated undifferentiated JJ 10_1101-2021_01_06_425581 33 37 cells cell NNS 10_1101-2021_01_06_425581 33 38 . . . 10_1101-2021_01_06_425581 34 1 The the DT 10_1101-2021_01_06_425581 34 2 rate rate NN 10_1101-2021_01_06_425581 34 3 at at IN 10_1101-2021_01_06_425581 34 4 which which WDT 10_1101-2021_01_06_425581 34 5 developmental developmental JJ 10_1101-2021_01_06_425581 34 6 cells cell NNS 10_1101-2021_01_06_425581 34 7 are be VBP 10_1101-2021_01_06_425581 34 8 produced produce VBN 10_1101-2021_01_06_425581 34 9 could could MD 10_1101-2021_01_06_425581 34 10 affect affect VB 10_1101-2021_01_06_425581 34 11 the the DT 10_1101-2021_01_06_425581 34 12 rate rate NN 10_1101-2021_01_06_425581 34 13 of of IN 10_1101-2021_01_06_425581 34 14 overall overall JJ 10_1101-2021_01_06_425581 34 15 development development NN 10_1101-2021_01_06_425581 34 16 , , , 10_1101-2021_01_06_425581 34 17 as as IN 10_1101-2021_01_06_425581 34 18 we -PRON- PRP 10_1101-2021_01_06_425581 34 19 will will MD 10_1101-2021_01_06_425581 34 20 see see VB 10_1101-2021_01_06_425581 34 21 in in IN 10_1101-2021_01_06_425581 34 22 an an DT 10_1101-2021_01_06_425581 34 23 example example NN 10_1101-2021_01_06_425581 34 24 from from IN 10_1101-2021_01_06_425581 34 25 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 34 26 . . . 10_1101-2021_01_06_425581 35 1 Finally finally RB 10_1101-2021_01_06_425581 35 2 , , , 10_1101-2021_01_06_425581 35 3 we -PRON- PRP 10_1101-2021_01_06_425581 35 4 predict predict VBP 10_1101-2021_01_06_425581 35 5 that that IN 10_1101-2021_01_06_425581 35 6 the the DT 10_1101-2021_01_06_425581 35 7 emergence emergence NN 10_1101-2021_01_06_425581 35 8 and and CC 10_1101-2021_01_06_425581 35 9 subsequent subsequent JJ 10_1101-2021_01_06_425581 35 10 changes change NNS 10_1101-2021_01_06_425581 35 11 in in IN 10_1101-2021_01_06_425581 35 12 spatiotemporal spatiotemporal JJ 10_1101-2021_01_06_425581 35 13 periodicity periodicity NN 10_1101-2021_01_06_425581 35 14 at at IN 10_1101-2021_01_06_425581 35 15 the the DT 10_1101-2021_01_06_425581 35 16 cellular cellular JJ 10_1101-2021_01_06_425581 35 17 level level NN 10_1101-2021_01_06_425581 35 18 lead lead NN 10_1101-2021_01_06_425581 35 19 to to IN 10_1101-2021_01_06_425581 35 20 regulatory regulatory JJ 10_1101-2021_01_06_425581 35 21 phase phase NN 10_1101-2021_01_06_425581 35 22 transitions transition NNS 10_1101-2021_01_06_425581 35 23 . . . 10_1101-2021_01_06_425581 36 1 For for IN 10_1101-2021_01_06_425581 36 2 example example NN 10_1101-2021_01_06_425581 36 3 , , , 10_1101-2021_01_06_425581 36 4 there there EX 10_1101-2021_01_06_425581 36 5 is be VBZ 10_1101-2021_01_06_425581 36 6 a a DT 10_1101-2021_01_06_425581 36 7 one one CD 10_1101-2021_01_06_425581 36 8 - - HYPH 10_1101-2021_01_06_425581 36 9 to to IN 10_1101-2021_01_06_425581 36 10 - - HYPH 10_1101-2021_01_06_425581 36 11 one one CD 10_1101-2021_01_06_425581 36 12 correspondence correspondence NN 10_1101-2021_01_06_425581 36 13 between between IN 10_1101-2021_01_06_425581 36 14 cell cell NN 10_1101-2021_01_06_425581 36 15 division division NN 10_1101-2021_01_06_425581 36 16 and and CC 10_1101-2021_01_06_425581 36 17 waves wave NNS 10_1101-2021_01_06_425581 36 18 of of IN 10_1101-2021_01_06_425581 36 19 differentiation differentiation NN 10_1101-2021_01_06_425581 36 20 after after IN 10_1101-2021_01_06_425581 36 21 the the DT 10_1101-2021_01_06_425581 36 22 syncytial syncytial JJ 10_1101-2021_01_06_425581 36 23 stage stage NN 10_1101-2021_01_06_425581 36 24 in in IN 10_1101-2021_01_06_425581 36 25 ​Drosophila ​drosophila JJ 10_1101-2021_01_06_425581 36 26 melanogaster melanogaster NN 10_1101-2021_01_06_425581 36 27 [ [ -LRB- 10_1101-2021_01_06_425581 36 28 10 10 CD 10_1101-2021_01_06_425581 36 29 ] ] -RRB- 10_1101-2021_01_06_425581 36 30 . . . 10_1101-2021_01_06_425581 37 1 In in IN 10_1101-2021_01_06_425581 37 2 a a DT 10_1101-2021_01_06_425581 37 3 similar similar JJ 10_1101-2021_01_06_425581 37 4 fashion fashion NN 10_1101-2021_01_06_425581 37 5 , , , 10_1101-2021_01_06_425581 37 6 amphibians amphibian NNS 10_1101-2021_01_06_425581 37 7 exhibit exhibit VBP 10_1101-2021_01_06_425581 37 8 a a DT 10_1101-2021_01_06_425581 37 9 decay decay NN 10_1101-2021_01_06_425581 37 10 of of IN 10_1101-2021_01_06_425581 37 11 synchrony synchrony NN 10_1101-2021_01_06_425581 37 12 of of IN 10_1101-2021_01_06_425581 37 13 division division NN 10_1101-2021_01_06_425581 37 14 [ [ -LRB- 10_1101-2021_01_06_425581 37 15 11 11 CD 10_1101-2021_01_06_425581 37 16 , , , 10_1101-2021_01_06_425581 37 17 12 12 CD 10_1101-2021_01_06_425581 37 18 ] ] -RRB- 10_1101-2021_01_06_425581 37 19 that that WDT 10_1101-2021_01_06_425581 37 20 corresponds correspond VBZ 10_1101-2021_01_06_425581 37 21 to to IN 10_1101-2021_01_06_425581 37 22 differentiation differentiation NN 10_1101-2021_01_06_425581 37 23 wave wave NN 10_1101-2021_01_06_425581 37 24 activity activity NN 10_1101-2021_01_06_425581 37 25 [ [ -LRB- 10_1101-2021_01_06_425581 37 26 13 13 CD 10_1101-2021_01_06_425581 37 27 ] ] -RRB- 10_1101-2021_01_06_425581 37 28 . . . 10_1101-2021_01_06_425581 38 1 Based base VBN 10_1101-2021_01_06_425581 38 2 on on IN 10_1101-2021_01_06_425581 38 3 data datum NNS 10_1101-2021_01_06_425581 38 4 analysis analysis NN 10_1101-2021_01_06_425581 38 5 , , , 10_1101-2021_01_06_425581 38 6 modeling modeling NN 10_1101-2021_01_06_425581 38 7 , , , 10_1101-2021_01_06_425581 38 8 and and CC 10_1101-2021_01_06_425581 38 9 literature literature NN 10_1101-2021_01_06_425581 38 10 review review NN 10_1101-2021_01_06_425581 38 11 , , , 10_1101-2021_01_06_425581 38 12 we -PRON- PRP 10_1101-2021_01_06_425581 38 13 anticipate anticipate VBP 10_1101-2021_01_06_425581 38 14 that that IN 10_1101-2021_01_06_425581 38 15 further further JJ 10_1101-2021_01_06_425581 38 16 investigation investigation NN 10_1101-2021_01_06_425581 38 17 could could MD 10_1101-2021_01_06_425581 38 18 uncover uncover VB 10_1101-2021_01_06_425581 38 19 whether whether IN 10_1101-2021_01_06_425581 38 20 , , , 10_1101-2021_01_06_425581 38 21 in in IN 10_1101-2021_01_06_425581 38 22 regulating regulate VBG 10_1101-2021_01_06_425581 38 23 embryos embryo NNS 10_1101-2021_01_06_425581 38 24 , , , 10_1101-2021_01_06_425581 38 25 mitosis mitosis NN 10_1101-2021_01_06_425581 38 26 and and CC 10_1101-2021_01_06_425581 38 27 cell cell NN 10_1101-2021_01_06_425581 38 28 differentiation differentiation NN 10_1101-2021_01_06_425581 38 29 are be VBP 10_1101-2021_01_06_425581 38 30 correlated correlate VBN 10_1101-2021_01_06_425581 38 31 . . . 10_1101-2021_01_06_425581 39 1 In in IN 10_1101-2021_01_06_425581 39 2 interpreting interpret VBG 10_1101-2021_01_06_425581 39 3 the the DT 10_1101-2021_01_06_425581 39 4 data datum NNS 10_1101-2021_01_06_425581 39 5 , , , 10_1101-2021_01_06_425581 39 6 we -PRON- PRP 10_1101-2021_01_06_425581 39 7 discuss discuss VBP 10_1101-2021_01_06_425581 39 8 the the DT 10_1101-2021_01_06_425581 39 9 potential potential JJ 10_1101-2021_01_06_425581 39 10 applicability applicability NN 10_1101-2021_01_06_425581 39 11 of of IN 10_1101-2021_01_06_425581 39 12 Holtzer Holtzer NNP 10_1101-2021_01_06_425581 39 13 ’s ’s POS 10_1101-2021_01_06_425581 39 14 quantal quantal JJ 10_1101-2021_01_06_425581 39 15 mitosis mitosis NN 10_1101-2021_01_06_425581 39 16 hypothesis hypothesis NN 10_1101-2021_01_06_425581 39 17 [ [ -LRB- 10_1101-2021_01_06_425581 39 18 14 14 CD 10_1101-2021_01_06_425581 39 19 , , , 10_1101-2021_01_06_425581 39 20 15 15 CD 10_1101-2021_01_06_425581 39 21 ] ] -RRB- 10_1101-2021_01_06_425581 39 22 as as IN 10_1101-2021_01_06_425581 39 23 it -PRON- PRP 10_1101-2021_01_06_425581 39 24 relates relate VBZ 10_1101-2021_01_06_425581 39 25 to to IN 10_1101-2021_01_06_425581 39 26 the the DT 10_1101-2021_01_06_425581 39 27 process process NN 10_1101-2021_01_06_425581 39 28 of of IN 10_1101-2021_01_06_425581 39 29 differentiation differentiation NN 10_1101-2021_01_06_425581 39 30 relative relative JJ 10_1101-2021_01_06_425581 39 31 to to IN 10_1101-2021_01_06_425581 39 32 the the DT 10_1101-2021_01_06_425581 39 33 proliferation proliferation NN 10_1101-2021_01_06_425581 39 34 of of IN 10_1101-2021_01_06_425581 39 35 developmental developmental JJ 10_1101-2021_01_06_425581 39 36 ( ( -LRB- 10_1101-2021_01_06_425581 39 37 undifferentiated undifferentiated JJ 10_1101-2021_01_06_425581 39 38 ) ) -RRB- 10_1101-2021_01_06_425581 39 39 cells cell NNS 10_1101-2021_01_06_425581 39 40 . . . 10_1101-2021_01_06_425581 40 1 Methods method NNS 10_1101-2021_01_06_425581 40 2 A a DT 10_1101-2021_01_06_425581 40 3 summary summary NN 10_1101-2021_01_06_425581 40 4 of of IN 10_1101-2021_01_06_425581 40 5 the the DT 10_1101-2021_01_06_425581 40 6 methods method NNS 10_1101-2021_01_06_425581 40 7 could could MD 10_1101-2021_01_06_425581 40 8 be be VB 10_1101-2021_01_06_425581 40 9 given give VBN 10_1101-2021_01_06_425581 40 10 here here RB 10_1101-2021_01_06_425581 40 11 for for IN 10_1101-2021_01_06_425581 40 12 smooth smooth JJ 10_1101-2021_01_06_425581 40 13 reading reading NN 10_1101-2021_01_06_425581 40 14 and and CC 10_1101-2021_01_06_425581 40 15 interest interest NN 10_1101-2021_01_06_425581 40 16 . . . 10_1101-2021_01_06_425581 41 1 All all DT 10_1101-2021_01_06_425581 41 2 materials material NNS 10_1101-2021_01_06_425581 41 3 are be VBP 10_1101-2021_01_06_425581 41 4 located locate VBN 10_1101-2021_01_06_425581 41 5 on on IN 10_1101-2021_01_06_425581 41 6 Github Github NNP 10_1101-2021_01_06_425581 41 7 : : : 10_1101-2021_01_06_425581 41 8 ​https://github.com ​https://github.com NNP 10_1101-2021_01_06_425581 41 9 / / SYM 10_1101-2021_01_06_425581 41 10 Orthogonal- Orthogonal- NNP 10_1101-2021_01_06_425581 41 11 Research Research NNP 10_1101-2021_01_06_425581 41 12 - - HYPH 10_1101-2021_01_06_425581 41 13 Lab Lab NNP 10_1101-2021_01_06_425581 41 14 / / SYM 10_1101-2021_01_06_425581 41 15 Periodicity Periodicity NNP 10_1101-2021_01_06_425581 41 16 - - HYPH 10_1101-2021_01_06_425581 41 17 in in IN 10_1101-2021_01_06_425581 41 18 - - HYPH 10_1101-2021_01_06_425581 41 19 the the DT 10_1101-2021_01_06_425581 41 20 - - HYPH 10_1101-2021_01_06_425581 41 21 Embryo embryo NN 10_1101-2021_01_06_425581 41 22 ​. ​. NN 10_1101-2021_01_06_425581 42 1 This this DT 10_1101-2021_01_06_425581 42 2 repository repository NN 10_1101-2021_01_06_425581 42 3 includes include VBZ 10_1101-2021_01_06_425581 42 4 processed process VBN 10_1101-2021_01_06_425581 42 5 data datum NNS 10_1101-2021_01_06_425581 42 6 , , , 10_1101-2021_01_06_425581 42 7 supplemental supplemental JJ 10_1101-2021_01_06_425581 42 8 materials material NNS 10_1101-2021_01_06_425581 42 9 , , , 10_1101-2021_01_06_425581 42 10 and and CC 10_1101-2021_01_06_425581 42 11 associated associate VBD 10_1101-2021_01_06_425581 42 12 code code NNP 10_1101-2021_01_06_425581 42 13 . . . 10_1101-2021_01_06_425581 43 1 Secondary secondary JJ 10_1101-2021_01_06_425581 43 2 Datasets dataset NNS 10_1101-2021_01_06_425581 43 3 The the DT 10_1101-2021_01_06_425581 43 4 ​C. ​c. NN 10_1101-2021_01_06_425581 44 1 elegans elegans NNPS 10_1101-2021_01_06_425581 44 2 ​and ​and VBD 10_1101-2021_01_06_425581 44 3 ​D. ​D. NNP 10_1101-2021_01_06_425581 45 1 rerio rerio NNP 10_1101-2021_01_06_425581 45 2 data data NN 10_1101-2021_01_06_425581 45 3 sets set NNS 10_1101-2021_01_06_425581 45 4 were be VBD 10_1101-2021_01_06_425581 45 5 acquired acquire VBN 10_1101-2021_01_06_425581 45 6 from from IN 10_1101-2021_01_06_425581 45 7 the the DT 10_1101-2021_01_06_425581 45 8 Systems Systems NNP 10_1101-2021_01_06_425581 45 9 Science Science NNP 10_1101-2021_01_06_425581 45 10 of of IN 10_1101-2021_01_06_425581 45 11 Biology Biology NNP 10_1101-2021_01_06_425581 45 12 Database Database NNP 10_1101-2021_01_06_425581 45 13 ( ( -LRB- 10_1101-2021_01_06_425581 45 14 ​http://ssbd.qbic.riken.jp/ ​http://ssbd.qbic.riken.jp/ NNP 10_1101-2021_01_06_425581 45 15 ​ ​ NNP 10_1101-2021_01_06_425581 45 16 ) ) -RRB- 10_1101-2021_01_06_425581 45 17 . . . 10_1101-2021_01_06_425581 46 1 The the DT 10_1101-2021_01_06_425581 46 2 ​C. ​C. NNP 10_1101-2021_01_06_425581 47 1 elegans elegans NNP 10_1101-2021_01_06_425581 47 2 ( ( -LRB- 10_1101-2021_01_06_425581 47 3 nematode nematode NNP 10_1101-2021_01_06_425581 47 4 ) ) -RRB- 10_1101-2021_01_06_425581 47 5 data datum NNS 10_1101-2021_01_06_425581 47 6 [ [ -LRB- 10_1101-2021_01_06_425581 47 7 16 16 CD 10_1101-2021_01_06_425581 47 8 ] ] -RRB- 10_1101-2021_01_06_425581 47 9 is be VBZ 10_1101-2021_01_06_425581 47 10 based base VBN 10_1101-2021_01_06_425581 47 11 on on IN 10_1101-2021_01_06_425581 47 12 cell cell NN 10_1101-2021_01_06_425581 47 13 tracking tracking NN 10_1101-2021_01_06_425581 47 14 of of IN 10_1101-2021_01_06_425581 47 15 the the DT 10_1101-2021_01_06_425581 47 16 nucleus nucleus NN 10_1101-2021_01_06_425581 47 17 , , , 10_1101-2021_01_06_425581 47 18 PMID:16477039 PMID:16477039 NNP 10_1101-2021_01_06_425581 47 19 . . . 10_1101-2021_01_06_425581 48 1 The the DT 10_1101-2021_01_06_425581 48 2 ​D. ​D. NNP 10_1101-2021_01_06_425581 49 1 rerio rerio NNP 10_1101-2021_01_06_425581 49 2 ( ( -LRB- 10_1101-2021_01_06_425581 49 3 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 49 4 ) ) -RRB- 10_1101-2021_01_06_425581 49 5 data datum NNS 10_1101-2021_01_06_425581 49 6 [ [ -LRB- 10_1101-2021_01_06_425581 49 7 17 17 CD 10_1101-2021_01_06_425581 49 8 ] ] -RRB- 10_1101-2021_01_06_425581 49 9 is be VBZ 10_1101-2021_01_06_425581 49 10 likewise likewise RB 10_1101-2021_01_06_425581 49 11 based base VBN 10_1101-2021_01_06_425581 49 12 on on IN 10_1101-2021_01_06_425581 49 13 cell cell NN 10_1101-2021_01_06_425581 49 14 track track NN 10_1101-2021_01_06_425581 49 15 of of IN 10_1101-2021_01_06_425581 49 16 the the DT 10_1101-2021_01_06_425581 49 17 nucleus nucleus NN 10_1101-2021_01_06_425581 49 18 , , , 10_1101-2021_01_06_425581 49 19 PMID:18845710 PMID:18845710 NNP 10_1101-2021_01_06_425581 49 20 . . . 10_1101-2021_01_06_425581 50 1 The the DT 10_1101-2021_01_06_425581 50 2 cell cell NN 10_1101-2021_01_06_425581 50 3 tracking tracking NN 10_1101-2021_01_06_425581 50 4 data datum NNS 10_1101-2021_01_06_425581 50 5 is be VBZ 10_1101-2021_01_06_425581 50 6 used use VBN 10_1101-2021_01_06_425581 50 7 to to TO 10_1101-2021_01_06_425581 50 8 determine determine VB 10_1101-2021_01_06_425581 50 9 the the DT 10_1101-2021_01_06_425581 50 10 total total JJ 10_1101-2021_01_06_425581 50 11 number number NN 10_1101-2021_01_06_425581 50 12 of of IN 10_1101-2021_01_06_425581 50 13 new new JJ 10_1101-2021_01_06_425581 50 14 cells cell NNS 10_1101-2021_01_06_425581 50 15 ( ( -LRB- 10_1101-2021_01_06_425581 50 16 cell cell NN 10_1101-2021_01_06_425581 50 17 birth birth NN 10_1101-2021_01_06_425581 50 18 time time NN 10_1101-2021_01_06_425581 50 19 ) ) -RRB- 10_1101-2021_01_06_425581 50 20 present present JJ 10_1101-2021_01_06_425581 50 21 at at IN 10_1101-2021_01_06_425581 50 22 a a DT 10_1101-2021_01_06_425581 50 23 particular particular JJ 10_1101-2021_01_06_425581 50 24 time time NN 10_1101-2021_01_06_425581 50 25 step step NN 10_1101-2021_01_06_425581 50 26 . . . 10_1101-2021_01_06_425581 51 1 For for IN 10_1101-2021_01_06_425581 51 2 the the DT 10_1101-2021_01_06_425581 51 3 ​C. ​C. NNP 10_1101-2021_01_06_425581 52 1 elegans elegans NNPS 10_1101-2021_01_06_425581 52 2 ​data ​data NNP 10_1101-2021_01_06_425581 52 3 , , , 10_1101-2021_01_06_425581 52 4 cell cell NN 10_1101-2021_01_06_425581 52 5 births birth NNS 10_1101-2021_01_06_425581 52 6 correspond correspond VBP 10_1101-2021_01_06_425581 52 7 to to IN 10_1101-2021_01_06_425581 52 8 minutes minute NNS 10_1101-2021_01_06_425581 52 9 of of IN 10_1101-2021_01_06_425581 52 10 developmental developmental JJ 10_1101-2021_01_06_425581 52 11 time time NN 10_1101-2021_01_06_425581 52 12 , , , 10_1101-2021_01_06_425581 52 13 and and CC 10_1101-2021_01_06_425581 52 14 windows window NNS 10_1101-2021_01_06_425581 52 15 of of IN 10_1101-2021_01_06_425581 52 16 size size NN 10_1101-2021_01_06_425581 52 17 five five CD 10_1101-2021_01_06_425581 52 18 ( ( -LRB- 10_1101-2021_01_06_425581 52 19 5 5 CD 10_1101-2021_01_06_425581 52 20 minutes minute NNS 10_1101-2021_01_06_425581 52 21 of of IN 10_1101-2021_01_06_425581 52 22 developmental developmental JJ 10_1101-2021_01_06_425581 52 23 time time NN 10_1101-2021_01_06_425581 52 24 ) ) -RRB- 10_1101-2021_01_06_425581 52 25 is be VBZ 10_1101-2021_01_06_425581 52 26 used use VBN 10_1101-2021_01_06_425581 52 27 for for IN 10_1101-2021_01_06_425581 52 28 the the DT 10_1101-2021_01_06_425581 52 29 time time NN 10_1101-2021_01_06_425581 52 30 - - HYPH 10_1101-2021_01_06_425581 52 31 series series NN 10_1101-2021_01_06_425581 52 32 plots plot NNS 10_1101-2021_01_06_425581 52 33 and and CC 10_1101-2021_01_06_425581 52 34 histograms histogram NNS 10_1101-2021_01_06_425581 52 35 . . . 10_1101-2021_01_06_425581 53 1 Since since IN 10_1101-2021_01_06_425581 53 2 lineage lineage NN 10_1101-2021_01_06_425581 53 3 trees tree NNS 10_1101-2021_01_06_425581 53 4 and and CC 10_1101-2021_01_06_425581 53 5 the the DT 10_1101-2021_01_06_425581 53 6 nature nature NN 10_1101-2021_01_06_425581 53 7 of of IN 10_1101-2021_01_06_425581 53 8 developmental developmental JJ 10_1101-2021_01_06_425581 53 9 1 1 CD 10_1101-2021_01_06_425581 53 10 .CC .CC NFP 10_1101-2021_01_06_425581 53 11 - - HYPH 10_1101-2021_01_06_425581 53 12 BY BY NNP 10_1101-2021_01_06_425581 53 13 - - HYPH 10_1101-2021_01_06_425581 53 14 NC NC NNP 10_1101-2021_01_06_425581 53 15 4.0 4.0 CD 10_1101-2021_01_06_425581 53 16 International international JJ 10_1101-2021_01_06_425581 53 17 licensemade licensemade NN 10_1101-2021_01_06_425581 53 18 available available JJ 10_1101-2021_01_06_425581 53 19 under under IN 10_1101-2021_01_06_425581 53 20 a a DT 10_1101-2021_01_06_425581 53 21 ( ( -LRB- 10_1101-2021_01_06_425581 53 22 which which WDT 10_1101-2021_01_06_425581 53 23 was be VBD 10_1101-2021_01_06_425581 53 24 not not RB 10_1101-2021_01_06_425581 53 25 certified certify VBN 10_1101-2021_01_06_425581 53 26 by by IN 10_1101-2021_01_06_425581 53 27 peer peer NN 10_1101-2021_01_06_425581 53 28 review review NN 10_1101-2021_01_06_425581 53 29 ) ) -RRB- 10_1101-2021_01_06_425581 53 30 is be VBZ 10_1101-2021_01_06_425581 53 31 the the DT 10_1101-2021_01_06_425581 53 32 author author NN 10_1101-2021_01_06_425581 53 33 / / SYM 10_1101-2021_01_06_425581 53 34 funder funder NN 10_1101-2021_01_06_425581 53 35 , , , 10_1101-2021_01_06_425581 53 36 who who WP 10_1101-2021_01_06_425581 53 37 has have VBZ 10_1101-2021_01_06_425581 53 38 granted grant VBN 10_1101-2021_01_06_425581 53 39 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 53 40 a a DT 10_1101-2021_01_06_425581 53 41 license license NN 10_1101-2021_01_06_425581 53 42 to to TO 10_1101-2021_01_06_425581 53 43 display display VB 10_1101-2021_01_06_425581 53 44 the the DT 10_1101-2021_01_06_425581 53 45 preprint preprint NN 10_1101-2021_01_06_425581 53 46 in in IN 10_1101-2021_01_06_425581 53 47 perpetuity perpetuity NN 10_1101-2021_01_06_425581 53 48 . . . 10_1101-2021_01_06_425581 54 1 It -PRON- PRP 10_1101-2021_01_06_425581 54 2 is be VBZ 10_1101-2021_01_06_425581 54 3 The the DT 10_1101-2021_01_06_425581 54 4 copyright copyright NN 10_1101-2021_01_06_425581 54 5 holder holder NN 10_1101-2021_01_06_425581 54 6 for for IN 10_1101-2021_01_06_425581 54 7 this this DT 10_1101-2021_01_06_425581 54 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 54 9 version version NN 10_1101-2021_01_06_425581 54 10 posted post VBD 10_1101-2021_01_06_425581 54 11 January January NNP 10_1101-2021_01_06_425581 54 12 8 8 CD 10_1101-2021_01_06_425581 54 13 , , , 10_1101-2021_01_06_425581 54 14 2021 2021 CD 10_1101-2021_01_06_425581 54 15 . . . 10_1101-2021_01_06_425581 54 16 ; ; : 10_1101-2021_01_06_425581 54 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 54 18 : : : 10_1101-2021_01_06_425581 54 19 bioRxiv biorxiv VB 10_1101-2021_01_06_425581 54 20 preprint preprint NN 10_1101-2021_01_06_425581 54 21 https://github.com/Orthogonal-Research-Lab/Periodicity-in-the-Embryo https://github.com/Orthogonal-Research-Lab/Periodicity-in-the-Embryo NNP 10_1101-2021_01_06_425581 54 22 https://github.com/Orthogonal-Research-Lab/Periodicity-in-the-Embryo https://github.com/Orthogonal-Research-Lab/Periodicity-in-the-Embryo NNP 10_1101-2021_01_06_425581 54 23 http://ssbd.qbic.riken.jp/ http://ssbd.qbic.riken.jp/ NNP 10_1101-2021_01_06_425581 54 24 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 54 25 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 54 26 cell cell NN 10_1101-2021_01_06_425581 54 27 identification identification NN 10_1101-2021_01_06_425581 54 28 are be VBP 10_1101-2021_01_06_425581 54 29 different different JJ 10_1101-2021_01_06_425581 54 30 in in IN 10_1101-2021_01_06_425581 54 31 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 54 32 , , , 10_1101-2021_01_06_425581 54 33 cell cell NN 10_1101-2021_01_06_425581 54 34 births birth NNS 10_1101-2021_01_06_425581 54 35 correspond correspond VBP 10_1101-2021_01_06_425581 54 36 to to IN 10_1101-2021_01_06_425581 54 37 the the DT 10_1101-2021_01_06_425581 54 38 number number NN 10_1101-2021_01_06_425581 54 39 of of IN 10_1101-2021_01_06_425581 54 40 observed observe VBN 10_1101-2021_01_06_425581 54 41 cells cell NNS 10_1101-2021_01_06_425581 54 42 at at IN 10_1101-2021_01_06_425581 54 43 discrete discrete JJ 10_1101-2021_01_06_425581 54 44 points point NNS 10_1101-2021_01_06_425581 54 45 in in IN 10_1101-2021_01_06_425581 54 46 developmental developmental JJ 10_1101-2021_01_06_425581 54 47 time time NN 10_1101-2021_01_06_425581 54 48 . . . 10_1101-2021_01_06_425581 55 1 Windows window NNS 10_1101-2021_01_06_425581 55 2 representing represent VBG 10_1101-2021_01_06_425581 55 3 a a DT 10_1101-2021_01_06_425581 55 4 certain certain JJ 10_1101-2021_01_06_425581 55 5 number number NN 10_1101-2021_01_06_425581 55 6 of of IN 10_1101-2021_01_06_425581 55 7 cells cell NNS 10_1101-2021_01_06_425581 55 8 in in IN 10_1101-2021_01_06_425581 55 9 the the DT 10_1101-2021_01_06_425581 55 10 embryo embryo NN 10_1101-2021_01_06_425581 55 11 observed observe VBD 10_1101-2021_01_06_425581 55 12 at at IN 10_1101-2021_01_06_425581 55 13 a a DT 10_1101-2021_01_06_425581 55 14 given give VBN 10_1101-2021_01_06_425581 55 15 sampling sampling NN 10_1101-2021_01_06_425581 55 16 point point NN 10_1101-2021_01_06_425581 55 17 are be VBP 10_1101-2021_01_06_425581 55 18 used use VBN 10_1101-2021_01_06_425581 55 19 instead instead RB 10_1101-2021_01_06_425581 55 20 of of IN 10_1101-2021_01_06_425581 55 21 directly directly RB 10_1101-2021_01_06_425581 55 22 converting convert VBG 10_1101-2021_01_06_425581 55 23 this this DT 10_1101-2021_01_06_425581 55 24 process process NN 10_1101-2021_01_06_425581 55 25 to to IN 10_1101-2021_01_06_425581 55 26 minutes minute NNS 10_1101-2021_01_06_425581 55 27 of of IN 10_1101-2021_01_06_425581 55 28 developmental developmental JJ 10_1101-2021_01_06_425581 55 29 time time NN 10_1101-2021_01_06_425581 55 30 . . . 10_1101-2021_01_06_425581 56 1 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 56 2 Developmental Developmental NNP 10_1101-2021_01_06_425581 56 3 Stages Stages NNPS 10_1101-2021_01_06_425581 56 4 Estimates Estimates NNPS 10_1101-2021_01_06_425581 56 5 and and CC 10_1101-2021_01_06_425581 56 6 calculations calculation NNS 10_1101-2021_01_06_425581 56 7 of of IN 10_1101-2021_01_06_425581 56 8 ​D. ​D. NNP 10_1101-2021_01_06_425581 57 1 rerio rerio VB 10_1101-2021_01_06_425581 57 2 developmental developmental JJ 10_1101-2021_01_06_425581 57 3 stages stage NNS 10_1101-2021_01_06_425581 57 4 are be VBP 10_1101-2021_01_06_425581 57 5 derived derive VBN 10_1101-2021_01_06_425581 57 6 from from IN 10_1101-2021_01_06_425581 57 7 [ [ -LRB- 10_1101-2021_01_06_425581 57 8 18 18 CD 10_1101-2021_01_06_425581 57 9 ] ] -RRB- 10_1101-2021_01_06_425581 57 10 and and CC 10_1101-2021_01_06_425581 57 11 the the DT 10_1101-2021_01_06_425581 57 12 ZFIN ZFIN NNP 10_1101-2021_01_06_425581 57 13 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 57 14 Developmental Developmental NNP 10_1101-2021_01_06_425581 57 15 Staging Staging NNP 10_1101-2021_01_06_425581 57 16 Series Series NNP 10_1101-2021_01_06_425581 57 17 web web NN 10_1101-2021_01_06_425581 57 18 resource resource NN 10_1101-2021_01_06_425581 57 19 ( ( -LRB- 10_1101-2021_01_06_425581 57 20 ​https://zfin.org ​https://zfin.org NNP 10_1101-2021_01_06_425581 57 21 / / SYM 10_1101-2021_01_06_425581 57 22 zf_info zf_info NNP 10_1101-2021_01_06_425581 57 23 / / SYM 10_1101-2021_01_06_425581 57 24 zfbook zfbook NNP 10_1101-2021_01_06_425581 57 25 / / SYM 10_1101-2021_01_06_425581 57 26 stages/​ stages/​ NNP 10_1101-2021_01_06_425581 57 27 ) ) -RRB- 10_1101-2021_01_06_425581 57 28 . . . 10_1101-2021_01_06_425581 58 1 Where where WRB 10_1101-2021_01_06_425581 58 2 applicable applicable JJ 10_1101-2021_01_06_425581 58 3 , , , 10_1101-2021_01_06_425581 58 4 embryo embryo NN 10_1101-2021_01_06_425581 58 5 stages stage NNS 10_1101-2021_01_06_425581 58 6 are be VBP 10_1101-2021_01_06_425581 58 7 approximated approximate VBN 10_1101-2021_01_06_425581 58 8 from from IN 10_1101-2021_01_06_425581 58 9 the the DT 10_1101-2021_01_06_425581 58 10 number number NN 10_1101-2021_01_06_425581 58 11 of of IN 10_1101-2021_01_06_425581 58 12 cells cell NNS 10_1101-2021_01_06_425581 58 13 observed observe VBN 10_1101-2021_01_06_425581 58 14 at at IN 10_1101-2021_01_06_425581 58 15 any any DT 10_1101-2021_01_06_425581 58 16 given give VBN 10_1101-2021_01_06_425581 58 17 point point NN 10_1101-2021_01_06_425581 58 18 in in IN 10_1101-2021_01_06_425581 58 19 developmental developmental JJ 10_1101-2021_01_06_425581 58 20 time time NN 10_1101-2021_01_06_425581 58 21 . . . 10_1101-2021_01_06_425581 59 1 Peak peak NN 10_1101-2021_01_06_425581 59 2 - - HYPH 10_1101-2021_01_06_425581 59 3 finding finding NN 10_1101-2021_01_06_425581 59 4 method method NN 10_1101-2021_01_06_425581 59 5 For for IN 10_1101-2021_01_06_425581 59 6 both both CC 10_1101-2021_01_06_425581 59 7 the the DT 10_1101-2021_01_06_425581 59 8 ​C. ​C. NNS 10_1101-2021_01_06_425581 60 1 elegans elegans NNPS 10_1101-2021_01_06_425581 60 2 and and CC 10_1101-2021_01_06_425581 60 3 ​D. ​D. NNP 10_1101-2021_01_06_425581 61 1 rerio rerio NNP 10_1101-2021_01_06_425581 61 2 data data NNP 10_1101-2021_01_06_425581 61 3 , , , 10_1101-2021_01_06_425581 61 4 a a DT 10_1101-2021_01_06_425581 61 5 peak peak NN 10_1101-2021_01_06_425581 61 6 finding finding NN 10_1101-2021_01_06_425581 61 7 method method NN 10_1101-2021_01_06_425581 61 8 is be VBZ 10_1101-2021_01_06_425581 61 9 used use VBN 10_1101-2021_01_06_425581 61 10 to to TO 10_1101-2021_01_06_425581 61 11 evaluate evaluate VB 10_1101-2021_01_06_425581 61 12 periodicity periodicity NN 10_1101-2021_01_06_425581 61 13 and and CC 10_1101-2021_01_06_425581 61 14 to to TO 10_1101-2021_01_06_425581 61 15 generate generate VB 10_1101-2021_01_06_425581 61 16 data data NN 10_1101-2021_01_06_425581 61 17 points point NNS 10_1101-2021_01_06_425581 61 18 representing represent VBG 10_1101-2021_01_06_425581 61 19 distinct distinct JJ 10_1101-2021_01_06_425581 61 20 bursts burst NNS 10_1101-2021_01_06_425581 61 21 of of IN 10_1101-2021_01_06_425581 61 22 cell cell NN 10_1101-2021_01_06_425581 61 23 birth birth NN 10_1101-2021_01_06_425581 61 24 . . . 10_1101-2021_01_06_425581 62 1 Briefly briefly RB 10_1101-2021_01_06_425581 62 2 , , , 10_1101-2021_01_06_425581 62 3 local local JJ 10_1101-2021_01_06_425581 62 4 peaks peak NNS 10_1101-2021_01_06_425581 62 5 in in IN 10_1101-2021_01_06_425581 62 6 the the DT 10_1101-2021_01_06_425581 62 7 cell cell NN 10_1101-2021_01_06_425581 62 8 division division NN 10_1101-2021_01_06_425581 62 9 series series NN 10_1101-2021_01_06_425581 62 10 are be VBP 10_1101-2021_01_06_425581 62 11 discovered discover VBN 10_1101-2021_01_06_425581 62 12 by by IN 10_1101-2021_01_06_425581 62 13 finding find VBG 10_1101-2021_01_06_425581 62 14 the the DT 10_1101-2021_01_06_425581 62 15 highest high JJS 10_1101-2021_01_06_425581 62 16 value value NN 10_1101-2021_01_06_425581 62 17 around around IN 10_1101-2021_01_06_425581 62 18 the the DT 10_1101-2021_01_06_425581 62 19 peak peak NN 10_1101-2021_01_06_425581 62 20 over over IN 10_1101-2021_01_06_425581 62 21 an an DT 10_1101-2021_01_06_425581 62 22 interval interval NN 10_1101-2021_01_06_425581 62 23 of of IN 10_1101-2021_01_06_425581 62 24 10 10 CD 10_1101-2021_01_06_425581 62 25 data datum NNS 10_1101-2021_01_06_425581 62 26 points point NNS 10_1101-2021_01_06_425581 62 27 . . . 10_1101-2021_01_06_425581 63 1 The the DT 10_1101-2021_01_06_425581 63 2 data datum NNS 10_1101-2021_01_06_425581 63 3 are be VBP 10_1101-2021_01_06_425581 63 4 then then RB 10_1101-2021_01_06_425581 63 5 visually visually RB 10_1101-2021_01_06_425581 63 6 inspected inspect VBN 10_1101-2021_01_06_425581 63 7 to to TO 10_1101-2021_01_06_425581 63 8 ensure ensure VB 10_1101-2021_01_06_425581 63 9 that that IN 10_1101-2021_01_06_425581 63 10 local local JJ 10_1101-2021_01_06_425581 63 11 maximal maximal JJ 10_1101-2021_01_06_425581 63 12 fluctuations fluctuation NNS 10_1101-2021_01_06_425581 63 13 were be VBD 10_1101-2021_01_06_425581 63 14 not not RB 10_1101-2021_01_06_425581 63 15 selected select VBN 10_1101-2021_01_06_425581 63 16 . . . 10_1101-2021_01_06_425581 64 1 Using use VBG 10_1101-2021_01_06_425581 64 2 this this DT 10_1101-2021_01_06_425581 64 3 segmentation segmentation NN 10_1101-2021_01_06_425581 64 4 method method NN 10_1101-2021_01_06_425581 64 5 , , , 10_1101-2021_01_06_425581 64 6 we -PRON- PRP 10_1101-2021_01_06_425581 64 7 are be VBP 10_1101-2021_01_06_425581 64 8 able able JJ 10_1101-2021_01_06_425581 64 9 to to TO 10_1101-2021_01_06_425581 64 10 define define VB 10_1101-2021_01_06_425581 64 11 intervals interval NNS 10_1101-2021_01_06_425581 64 12 between between IN 10_1101-2021_01_06_425581 64 13 peaks peak NNS 10_1101-2021_01_06_425581 64 14 in in IN 10_1101-2021_01_06_425581 64 15 a a DT 10_1101-2021_01_06_425581 64 16 way way NN 10_1101-2021_01_06_425581 64 17 that that WDT 10_1101-2021_01_06_425581 64 18 allows allow VBZ 10_1101-2021_01_06_425581 64 19 for for IN 10_1101-2021_01_06_425581 64 20 the the DT 10_1101-2021_01_06_425581 64 21 aperiodic aperiodic JJ 10_1101-2021_01_06_425581 64 22 regions region NNS 10_1101-2021_01_06_425581 64 23 of of IN 10_1101-2021_01_06_425581 64 24 our -PRON- PRP$ 10_1101-2021_01_06_425581 64 25 series series NN 10_1101-2021_01_06_425581 64 26 to to TO 10_1101-2021_01_06_425581 64 27 be be VB 10_1101-2021_01_06_425581 64 28 compared compare VBN 10_1101-2021_01_06_425581 64 29 to to IN 10_1101-2021_01_06_425581 64 30 the the DT 10_1101-2021_01_06_425581 64 31 highly highly RB 10_1101-2021_01_06_425581 64 32 periodic periodic JJ 10_1101-2021_01_06_425581 64 33 regions region NNS 10_1101-2021_01_06_425581 64 34 . . . 10_1101-2021_01_06_425581 65 1 The the DT 10_1101-2021_01_06_425581 65 2 peak peak NN 10_1101-2021_01_06_425581 65 3 finding finding NN 10_1101-2021_01_06_425581 65 4 method method NN 10_1101-2021_01_06_425581 65 5 results result NNS 10_1101-2021_01_06_425581 65 6 are be VBP 10_1101-2021_01_06_425581 65 7 supplemented supplement VBN 10_1101-2021_01_06_425581 65 8 by by IN 10_1101-2021_01_06_425581 65 9 a a DT 10_1101-2021_01_06_425581 65 10 Fast Fast NNP 10_1101-2021_01_06_425581 65 11 Frequency Frequency NNP 10_1101-2021_01_06_425581 65 12 Analysis Analysis NNP 10_1101-2021_01_06_425581 65 13 ( ( -LRB- 10_1101-2021_01_06_425581 65 14 FFT FFT NNP 10_1101-2021_01_06_425581 65 15 ) ) -RRB- 10_1101-2021_01_06_425581 65 16 of of IN 10_1101-2021_01_06_425581 65 17 cell cell NN 10_1101-2021_01_06_425581 65 18 divisions division NNS 10_1101-2021_01_06_425581 65 19 in in IN 10_1101-2021_01_06_425581 65 20 ​C. ​C. NNP 10_1101-2021_01_06_425581 66 1 elegans elegans NNPS 10_1101-2021_01_06_425581 66 2 embryo embryo NNP 10_1101-2021_01_06_425581 66 3 ( ( -LRB- 10_1101-2021_01_06_425581 66 4 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 66 5 Figure Figure NNP 10_1101-2021_01_06_425581 66 6 2 2 CD 10_1101-2021_01_06_425581 66 7 ) ) -RRB- 10_1101-2021_01_06_425581 66 8 , , , 10_1101-2021_01_06_425581 66 9 cell cell NN 10_1101-2021_01_06_425581 66 10 differentiation differentiation NN 10_1101-2021_01_06_425581 66 11 events event NNS 10_1101-2021_01_06_425581 66 12 in in IN 10_1101-2021_01_06_425581 66 13 ​C. ​c. ADD 10_1101-2021_01_06_425581 67 1 elegans elegans NNPS 10_1101-2021_01_06_425581 67 2 embryo embryo NNP 10_1101-2021_01_06_425581 67 3 ( ( -LRB- 10_1101-2021_01_06_425581 67 4 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 67 5 Figure Figure NNP 10_1101-2021_01_06_425581 67 6 3 3 CD 10_1101-2021_01_06_425581 67 7 ) ) -RRB- 10_1101-2021_01_06_425581 67 8 , , , 10_1101-2021_01_06_425581 67 9 and and CC 10_1101-2021_01_06_425581 67 10 time time NN 10_1101-2021_01_06_425581 67 11 series series NN 10_1101-2021_01_06_425581 67 12 for for IN 10_1101-2021_01_06_425581 67 13 cell cell NN 10_1101-2021_01_06_425581 67 14 divisions division NNS 10_1101-2021_01_06_425581 67 15 in in IN 10_1101-2021_01_06_425581 67 16 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 67 17 embryo embryo NN 10_1101-2021_01_06_425581 67 18 ( ( -LRB- 10_1101-2021_01_06_425581 67 19 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 67 20 Figure Figure NNP 10_1101-2021_01_06_425581 67 21 4 4 CD 10_1101-2021_01_06_425581 67 22 ) ) -RRB- 10_1101-2021_01_06_425581 67 23 . . . 10_1101-2021_01_06_425581 68 1 The the DT 10_1101-2021_01_06_425581 68 2 power power NN 10_1101-2021_01_06_425581 68 3 spectra spectra NNP 10_1101-2021_01_06_425581 68 4 largely largely RB 10_1101-2021_01_06_425581 68 5 confirm confirm VBP 10_1101-2021_01_06_425581 68 6 the the DT 10_1101-2021_01_06_425581 68 7 nature nature NN 10_1101-2021_01_06_425581 68 8 of of IN 10_1101-2021_01_06_425581 68 9 our -PRON- PRP$ 10_1101-2021_01_06_425581 68 10 interval interval NN 10_1101-2021_01_06_425581 68 11 and and CC 10_1101-2021_01_06_425581 68 12 peak peak NN 10_1101-2021_01_06_425581 68 13 analysis analysis NN 10_1101-2021_01_06_425581 68 14 . . . 10_1101-2021_01_06_425581 69 1 While while IN 10_1101-2021_01_06_425581 69 2 the the DT 10_1101-2021_01_06_425581 69 3 analysis analysis NN 10_1101-2021_01_06_425581 69 4 of of IN 10_1101-2021_01_06_425581 69 5 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 69 6 reveals reveal VBZ 10_1101-2021_01_06_425581 69 7 a a DT 10_1101-2021_01_06_425581 69 8 power power NN 10_1101-2021_01_06_425581 69 9 spectrum spectrum NN 10_1101-2021_01_06_425581 69 10 at at IN 10_1101-2021_01_06_425581 69 11 a a DT 10_1101-2021_01_06_425581 69 12 single single JJ 10_1101-2021_01_06_425581 69 13 scale scale NN 10_1101-2021_01_06_425581 69 14 , , , 10_1101-2021_01_06_425581 69 15 the the DT 10_1101-2021_01_06_425581 69 16 C. C. NNP 10_1101-2021_01_06_425581 69 17 elegans elegans NNPS 10_1101-2021_01_06_425581 69 18 embryo embryo VBD 10_1101-2021_01_06_425581 69 19 reveals reveal VBZ 10_1101-2021_01_06_425581 69 20 a a DT 10_1101-2021_01_06_425581 69 21 power power NN 10_1101-2021_01_06_425581 69 22 spectrum spectrum NN 10_1101-2021_01_06_425581 69 23 of of IN 10_1101-2021_01_06_425581 69 24 multiple multiple JJ 10_1101-2021_01_06_425581 69 25 time time NN 10_1101-2021_01_06_425581 69 26 scales scale NNS 10_1101-2021_01_06_425581 69 27 for for IN 10_1101-2021_01_06_425581 69 28 both both DT 10_1101-2021_01_06_425581 69 29 cell cell NN 10_1101-2021_01_06_425581 69 30 divisions division NNS 10_1101-2021_01_06_425581 69 31 and and CC 10_1101-2021_01_06_425581 69 32 differentiations differentiation NNS 10_1101-2021_01_06_425581 69 33 . . . 10_1101-2021_01_06_425581 70 1 Embryo embryo NN 10_1101-2021_01_06_425581 70 2 Networks network NNS 10_1101-2021_01_06_425581 70 3 The the DT 10_1101-2021_01_06_425581 70 4 full full JJ 10_1101-2021_01_06_425581 70 5 methodology methodology NN 10_1101-2021_01_06_425581 70 6 for for IN 10_1101-2021_01_06_425581 70 7 constructing construct VBG 10_1101-2021_01_06_425581 70 8 and and CC 10_1101-2021_01_06_425581 70 9 evaluating evaluate VBG 10_1101-2021_01_06_425581 70 10 can can MD 10_1101-2021_01_06_425581 70 11 be be VB 10_1101-2021_01_06_425581 70 12 found find VBN 10_1101-2021_01_06_425581 70 13 in in IN 10_1101-2021_01_06_425581 70 14 [ [ -LRB- 10_1101-2021_01_06_425581 70 15 7 7 CD 10_1101-2021_01_06_425581 70 16 ] ] -RRB- 10_1101-2021_01_06_425581 70 17 . . . 10_1101-2021_01_06_425581 71 1 Briefly briefly RB 10_1101-2021_01_06_425581 71 2 , , , 10_1101-2021_01_06_425581 71 3 embryo embryo NN 10_1101-2021_01_06_425581 71 4 networks network NNS 10_1101-2021_01_06_425581 71 5 are be VBP 10_1101-2021_01_06_425581 71 6 complex complex JJ 10_1101-2021_01_06_425581 71 7 networks network NNS 10_1101-2021_01_06_425581 71 8 constructed construct VBN 10_1101-2021_01_06_425581 71 9 from from IN 10_1101-2021_01_06_425581 71 10 the the DT 10_1101-2021_01_06_425581 71 11 locations location NNS 10_1101-2021_01_06_425581 71 12 of of IN 10_1101-2021_01_06_425581 71 13 cells cell NNS 10_1101-2021_01_06_425581 71 14 in in IN 10_1101-2021_01_06_425581 71 15 an an DT 10_1101-2021_01_06_425581 71 16 embryo embryo NN 10_1101-2021_01_06_425581 71 17 . . . 10_1101-2021_01_06_425581 72 1 Nodes node NNS 10_1101-2021_01_06_425581 72 2 are be VBP 10_1101-2021_01_06_425581 72 3 represented represent VBN 10_1101-2021_01_06_425581 72 4 by by IN 10_1101-2021_01_06_425581 72 5 centroids centroid NNS 10_1101-2021_01_06_425581 72 6 representing represent VBG 10_1101-2021_01_06_425581 72 7 cell cell NN 10_1101-2021_01_06_425581 72 8 nuclei nucleus NNS 10_1101-2021_01_06_425581 72 9 , , , 10_1101-2021_01_06_425581 72 10 and and CC 10_1101-2021_01_06_425581 72 11 edges edge NNS 10_1101-2021_01_06_425581 72 12 represent represent VBP 10_1101-2021_01_06_425581 72 13 the the DT 10_1101-2021_01_06_425581 72 14 spatial spatial JJ 10_1101-2021_01_06_425581 72 15 ( ( -LRB- 10_1101-2021_01_06_425581 72 16 Euclidean Euclidean NNP 10_1101-2021_01_06_425581 72 17 ) ) -RRB- 10_1101-2021_01_06_425581 72 18 distance distance NN 10_1101-2021_01_06_425581 72 19 between between IN 10_1101-2021_01_06_425581 72 20 cells cell NNS 10_1101-2021_01_06_425581 72 21 in in IN 10_1101-2021_01_06_425581 72 22 a a DT 10_1101-2021_01_06_425581 72 23 three- three- JJ 10_1101-2021_01_06_425581 72 24 ( ( -LRB- 10_1101-2021_01_06_425581 72 25 static static JJ 10_1101-2021_01_06_425581 72 26 ) ) -RRB- 10_1101-2021_01_06_425581 72 27 or or CC 10_1101-2021_01_06_425581 72 28 four- four- NNP 10_1101-2021_01_06_425581 72 29 ( ( -LRB- 10_1101-2021_01_06_425581 72 30 dynamic dynamic JJ 10_1101-2021_01_06_425581 72 31 ) ) -RRB- 10_1101-2021_01_06_425581 72 32 dimensional dimensional JJ 10_1101-2021_01_06_425581 72 33 graph graph NN 10_1101-2021_01_06_425581 72 34 . . . 10_1101-2021_01_06_425581 73 1 All all DT 10_1101-2021_01_06_425581 73 2 nuclei nucleus NNS 10_1101-2021_01_06_425581 73 3 are be VBP 10_1101-2021_01_06_425581 73 4 plotted plot VBN 10_1101-2021_01_06_425581 73 5 in in IN 10_1101-2021_01_06_425581 73 6 embryo embryo NN 10_1101-2021_01_06_425581 73 7 space space NN 10_1101-2021_01_06_425581 73 8 , , , 10_1101-2021_01_06_425581 73 9 which which WDT 10_1101-2021_01_06_425581 73 10 is be VBZ 10_1101-2021_01_06_425581 73 11 a a DT 10_1101-2021_01_06_425581 73 12 coordinate coordinate JJ 10_1101-2021_01_06_425581 73 13 system system NN 10_1101-2021_01_06_425581 73 14 normalized normalize VBD 10_1101-2021_01_06_425581 73 15 to to IN 10_1101-2021_01_06_425581 73 16 the the DT 10_1101-2021_01_06_425581 73 17 center center NN 10_1101-2021_01_06_425581 73 18 point point NN 10_1101-2021_01_06_425581 73 19 between between IN 10_1101-2021_01_06_425581 73 20 all all DT 10_1101-2021_01_06_425581 73 21 cell cell NN 10_1101-2021_01_06_425581 73 22 locations location NNS 10_1101-2021_01_06_425581 73 23 in in IN 10_1101-2021_01_06_425581 73 24 a a DT 10_1101-2021_01_06_425581 73 25 complete complete JJ 10_1101-2021_01_06_425581 73 26 embryo embryo NN 10_1101-2021_01_06_425581 73 27 . . . 10_1101-2021_01_06_425581 74 1 For for IN 10_1101-2021_01_06_425581 74 2 example example NN 10_1101-2021_01_06_425581 74 3 , , , 10_1101-2021_01_06_425581 74 4 an an DT 10_1101-2021_01_06_425581 74 5 edge edge NN 10_1101-2021_01_06_425581 74 6 of of IN 10_1101-2021_01_06_425581 74 7 length length NN 10_1101-2021_01_06_425581 74 8 1.0 1.0 CD 10_1101-2021_01_06_425581 74 9 represents represent VBZ 10_1101-2021_01_06_425581 74 10 two two CD 10_1101-2021_01_06_425581 74 11 centroids centroid NNS 10_1101-2021_01_06_425581 74 12 at at IN 10_1101-2021_01_06_425581 74 13 opposite opposite JJ 10_1101-2021_01_06_425581 74 14 edges edge NNS 10_1101-2021_01_06_425581 74 15 of of IN 10_1101-2021_01_06_425581 74 16 the the DT 10_1101-2021_01_06_425581 74 17 embryo embryo NN 10_1101-2021_01_06_425581 74 18 space space NN 10_1101-2021_01_06_425581 74 19 . . . 10_1101-2021_01_06_425581 75 1 A a DT 10_1101-2021_01_06_425581 75 2 distance distance NN 10_1101-2021_01_06_425581 75 3 threshold threshold NN 10_1101-2021_01_06_425581 75 4 is be VBZ 10_1101-2021_01_06_425581 75 5 then then RB 10_1101-2021_01_06_425581 75 6 derived derive VBN 10_1101-2021_01_06_425581 75 7 from from IN 10_1101-2021_01_06_425581 75 8 the the DT 10_1101-2021_01_06_425581 75 9 length length NN 10_1101-2021_01_06_425581 75 10 of of IN 10_1101-2021_01_06_425581 75 11 the the DT 10_1101-2021_01_06_425581 75 12 edge edge NN 10_1101-2021_01_06_425581 75 13 : : : 10_1101-2021_01_06_425581 75 14 in in IN 10_1101-2021_01_06_425581 75 15 this this DT 10_1101-2021_01_06_425581 75 16 paper paper NN 10_1101-2021_01_06_425581 75 17 , , , 10_1101-2021_01_06_425581 75 18 a a DT 10_1101-2021_01_06_425581 75 19 distance distance NN 10_1101-2021_01_06_425581 75 20 threshold threshold NN 10_1101-2021_01_06_425581 75 21 of of IN 10_1101-2021_01_06_425581 75 22 0.05 0.05 CD 10_1101-2021_01_06_425581 75 23 is be VBZ 10_1101-2021_01_06_425581 75 24 used use VBN 10_1101-2021_01_06_425581 75 25 , , , 10_1101-2021_01_06_425581 75 26 excluding exclude VBG 10_1101-2021_01_06_425581 75 27 all all DT 10_1101-2021_01_06_425581 75 28 but but IN 10_1101-2021_01_06_425581 75 29 the the DT 10_1101-2021_01_06_425581 75 30 cell cell NN 10_1101-2021_01_06_425581 75 31 nuclei nucleus NNS 10_1101-2021_01_06_425581 75 32 in in IN 10_1101-2021_01_06_425581 75 33 very very RB 10_1101-2021_01_06_425581 75 34 close close JJ 10_1101-2021_01_06_425581 75 35 proximity proximity NN 10_1101-2021_01_06_425581 75 36 to to IN 10_1101-2021_01_06_425581 75 37 each each DT 10_1101-2021_01_06_425581 75 38 other other JJ 10_1101-2021_01_06_425581 75 39 . . . 10_1101-2021_01_06_425581 76 1 Numeric Numeric NNP 10_1101-2021_01_06_425581 76 2 Embryo Embryo NNP 10_1101-2021_01_06_425581 76 3 Numeric Numeric NNP 10_1101-2021_01_06_425581 76 4 embryos embryo NNS 10_1101-2021_01_06_425581 76 5 are be VBP 10_1101-2021_01_06_425581 76 6 statistical statistical JJ 10_1101-2021_01_06_425581 76 7 summaries summary NNS 10_1101-2021_01_06_425581 76 8 of of IN 10_1101-2021_01_06_425581 76 9 the the DT 10_1101-2021_01_06_425581 76 10 type type NN 10_1101-2021_01_06_425581 76 11 of of IN 10_1101-2021_01_06_425581 76 12 information information NN 10_1101-2021_01_06_425581 76 13 acquired acquire VBN 10_1101-2021_01_06_425581 76 14 from from IN 10_1101-2021_01_06_425581 76 15 our -PRON- PRP$ 10_1101-2021_01_06_425581 76 16 secondary secondary JJ 10_1101-2021_01_06_425581 76 17 datasets dataset NNS 10_1101-2021_01_06_425581 76 18 , , , 10_1101-2021_01_06_425581 76 19 but but CC 10_1101-2021_01_06_425581 76 20 in in IN 10_1101-2021_01_06_425581 76 21 a a DT 10_1101-2021_01_06_425581 76 22 more more RBR 10_1101-2021_01_06_425581 76 23 generic generic JJ 10_1101-2021_01_06_425581 76 24 manner manner NN 10_1101-2021_01_06_425581 76 25 . . . 10_1101-2021_01_06_425581 77 1 Numeric numeric JJ 10_1101-2021_01_06_425581 77 2 embryos embryo NNS 10_1101-2021_01_06_425581 77 3 are be VBP 10_1101-2021_01_06_425581 77 4 based base VBN 10_1101-2021_01_06_425581 77 5 on on IN 10_1101-2021_01_06_425581 77 6 generated generate VBN 10_1101-2021_01_06_425581 77 7 pseudo pseudo NNP 10_1101-2021_01_06_425581 77 8 data datum NNS 10_1101-2021_01_06_425581 77 9 and and CC 10_1101-2021_01_06_425581 77 10 are be VBP 10_1101-2021_01_06_425581 77 11 meant mean VBN 10_1101-2021_01_06_425581 77 12 to to TO 10_1101-2021_01_06_425581 77 13 capture capture VB 10_1101-2021_01_06_425581 77 14 the the DT 10_1101-2021_01_06_425581 77 15 structure structure NN 10_1101-2021_01_06_425581 77 16 of of IN 10_1101-2021_01_06_425581 77 17 hypothetical hypothetical JJ 10_1101-2021_01_06_425581 77 18 developmental developmental JJ 10_1101-2021_01_06_425581 77 19 scenarios scenario NNS 10_1101-2021_01_06_425581 77 20 . . . 10_1101-2021_01_06_425581 78 1 All all DT 10_1101-2021_01_06_425581 78 2 analyses analysis NNS 10_1101-2021_01_06_425581 78 3 of of IN 10_1101-2021_01_06_425581 78 4 our -PRON- PRP$ 10_1101-2021_01_06_425581 78 5 pseudo pseudo NN 10_1101-2021_01_06_425581 78 6 data datum NNS 10_1101-2021_01_06_425581 78 7 were be VBD 10_1101-2021_01_06_425581 78 8 conducted conduct VBN 10_1101-2021_01_06_425581 78 9 using use VBG 10_1101-2021_01_06_425581 78 10 SciLab SciLab NNP 10_1101-2021_01_06_425581 78 11 6.1 6.1 CD 10_1101-2021_01_06_425581 78 12 ( ( -LRB- 10_1101-2021_01_06_425581 78 13 Paris Paris NNP 10_1101-2021_01_06_425581 78 14 , , , 10_1101-2021_01_06_425581 78 15 France France NNP 10_1101-2021_01_06_425581 78 16 ) ) -RRB- 10_1101-2021_01_06_425581 78 17 . . . 10_1101-2021_01_06_425581 79 1 Each each DT 10_1101-2021_01_06_425581 79 2 numeric numeric JJ 10_1101-2021_01_06_425581 79 3 embryo embryo NN 10_1101-2021_01_06_425581 79 4 consists consist VBZ 10_1101-2021_01_06_425581 79 5 of of IN 10_1101-2021_01_06_425581 79 6 one one CD 10_1101-2021_01_06_425581 79 7 or or CC 10_1101-2021_01_06_425581 79 8 more more JJR 10_1101-2021_01_06_425581 79 9 vectors vector NNS 10_1101-2021_01_06_425581 79 10 describing describe VBG 10_1101-2021_01_06_425581 79 11 rounds round NNS 10_1101-2021_01_06_425581 79 12 of of IN 10_1101-2021_01_06_425581 79 13 cell cell NN 10_1101-2021_01_06_425581 79 14 division division NN 10_1101-2021_01_06_425581 79 15 in in IN 10_1101-2021_01_06_425581 79 16 the the DT 10_1101-2021_01_06_425581 79 17 embryo embryo NN 10_1101-2021_01_06_425581 79 18 . . . 10_1101-2021_01_06_425581 80 1 Briefly briefly RB 10_1101-2021_01_06_425581 80 2 , , , 10_1101-2021_01_06_425581 80 3 each each DT 10_1101-2021_01_06_425581 80 4 minute minute NN 10_1101-2021_01_06_425581 80 5 of of IN 10_1101-2021_01_06_425581 80 6 developmental developmental JJ 10_1101-2021_01_06_425581 80 7 time time NN 10_1101-2021_01_06_425581 80 8 is be VBZ 10_1101-2021_01_06_425581 80 9 represented represent VBN 10_1101-2021_01_06_425581 80 10 by by IN 10_1101-2021_01_06_425581 80 11 either either CC 10_1101-2021_01_06_425581 80 12 a a DT 10_1101-2021_01_06_425581 80 13 zero zero CD 10_1101-2021_01_06_425581 80 14 or or CC 10_1101-2021_01_06_425581 80 15 a a DT 10_1101-2021_01_06_425581 80 16 positive positive JJ 10_1101-2021_01_06_425581 80 17 non non JJ 10_1101-2021_01_06_425581 80 18 - - JJ 10_1101-2021_01_06_425581 80 19 zero zero JJ 10_1101-2021_01_06_425581 80 20 value value NN 10_1101-2021_01_06_425581 80 21 . . . 10_1101-2021_01_06_425581 81 1 For for IN 10_1101-2021_01_06_425581 81 2 2 2 CD 10_1101-2021_01_06_425581 81 3 .CC .CC , 10_1101-2021_01_06_425581 81 4 - - HYPH 10_1101-2021_01_06_425581 81 5 BY BY NNP 10_1101-2021_01_06_425581 81 6 - - HYPH 10_1101-2021_01_06_425581 81 7 NC NC NNP 10_1101-2021_01_06_425581 81 8 4.0 4.0 CD 10_1101-2021_01_06_425581 81 9 International international JJ 10_1101-2021_01_06_425581 81 10 licensemade licensemade NN 10_1101-2021_01_06_425581 81 11 available available JJ 10_1101-2021_01_06_425581 81 12 under under IN 10_1101-2021_01_06_425581 81 13 a a DT 10_1101-2021_01_06_425581 81 14 ( ( -LRB- 10_1101-2021_01_06_425581 81 15 which which WDT 10_1101-2021_01_06_425581 81 16 was be VBD 10_1101-2021_01_06_425581 81 17 not not RB 10_1101-2021_01_06_425581 81 18 certified certify VBN 10_1101-2021_01_06_425581 81 19 by by IN 10_1101-2021_01_06_425581 81 20 peer peer NN 10_1101-2021_01_06_425581 81 21 review review NN 10_1101-2021_01_06_425581 81 22 ) ) -RRB- 10_1101-2021_01_06_425581 81 23 is be VBZ 10_1101-2021_01_06_425581 81 24 the the DT 10_1101-2021_01_06_425581 81 25 author author NN 10_1101-2021_01_06_425581 81 26 / / SYM 10_1101-2021_01_06_425581 81 27 funder funder NN 10_1101-2021_01_06_425581 81 28 , , , 10_1101-2021_01_06_425581 81 29 who who WP 10_1101-2021_01_06_425581 81 30 has have VBZ 10_1101-2021_01_06_425581 81 31 granted grant VBN 10_1101-2021_01_06_425581 81 32 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 81 33 a a DT 10_1101-2021_01_06_425581 81 34 license license NN 10_1101-2021_01_06_425581 81 35 to to TO 10_1101-2021_01_06_425581 81 36 display display VB 10_1101-2021_01_06_425581 81 37 the the DT 10_1101-2021_01_06_425581 81 38 preprint preprint NN 10_1101-2021_01_06_425581 81 39 in in IN 10_1101-2021_01_06_425581 81 40 perpetuity perpetuity NN 10_1101-2021_01_06_425581 81 41 . . . 10_1101-2021_01_06_425581 82 1 It -PRON- PRP 10_1101-2021_01_06_425581 82 2 is be VBZ 10_1101-2021_01_06_425581 82 3 The the DT 10_1101-2021_01_06_425581 82 4 copyright copyright NN 10_1101-2021_01_06_425581 82 5 holder holder NN 10_1101-2021_01_06_425581 82 6 for for IN 10_1101-2021_01_06_425581 82 7 this this DT 10_1101-2021_01_06_425581 82 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 82 9 version version NN 10_1101-2021_01_06_425581 82 10 posted post VBD 10_1101-2021_01_06_425581 82 11 January January NNP 10_1101-2021_01_06_425581 82 12 8 8 CD 10_1101-2021_01_06_425581 82 13 , , , 10_1101-2021_01_06_425581 82 14 2021 2021 CD 10_1101-2021_01_06_425581 82 15 . . . 10_1101-2021_01_06_425581 82 16 ; ; : 10_1101-2021_01_06_425581 82 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 82 18 : : : 10_1101-2021_01_06_425581 82 19 bioRxiv biorxiv VB 10_1101-2021_01_06_425581 82 20 preprint preprint NN 10_1101-2021_01_06_425581 82 21 https://zfin.org/zf_info/zfbook/stages/ https://zfin.org/zf_info/zfbook/stages/ JJ 10_1101-2021_01_06_425581 82 22 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 NNP 10_1101-2021_01_06_425581 82 23 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NN 10_1101-2021_01_06_425581 82 24 purposes purpose NNS 10_1101-2021_01_06_425581 82 25 of of IN 10_1101-2021_01_06_425581 82 26 temporal temporal JJ 10_1101-2021_01_06_425581 82 27 comparison comparison NN 10_1101-2021_01_06_425581 82 28 , , , 10_1101-2021_01_06_425581 82 29 all all DT 10_1101-2021_01_06_425581 82 30 non non JJ 10_1101-2021_01_06_425581 82 31 - - JJ 10_1101-2021_01_06_425581 82 32 zero zero JJ 10_1101-2021_01_06_425581 82 33 values value NNS 10_1101-2021_01_06_425581 82 34 are be VBP 10_1101-2021_01_06_425581 82 35 thresholded thresholde VBN 10_1101-2021_01_06_425581 82 36 to to IN 10_1101-2021_01_06_425581 82 37 one one CD 10_1101-2021_01_06_425581 82 38 . . . 10_1101-2021_01_06_425581 83 1 To to TO 10_1101-2021_01_06_425581 83 2 generate generate VB 10_1101-2021_01_06_425581 83 3 cell cell NN 10_1101-2021_01_06_425581 83 4 division division NN 10_1101-2021_01_06_425581 83 5 intervals interval NNS 10_1101-2021_01_06_425581 83 6 of of IN 10_1101-2021_01_06_425581 83 7 different different JJ 10_1101-2021_01_06_425581 83 8 sizes size NNS 10_1101-2021_01_06_425581 83 9 , , , 10_1101-2021_01_06_425581 83 10 we -PRON- PRP 10_1101-2021_01_06_425581 83 11 start start VBP 10_1101-2021_01_06_425581 83 12 with with IN 10_1101-2021_01_06_425581 83 13 a a DT 10_1101-2021_01_06_425581 83 14 uniform uniform JJ 10_1101-2021_01_06_425581 83 15 distribution distribution NN 10_1101-2021_01_06_425581 83 16 ( ( -LRB- 10_1101-2021_01_06_425581 83 17 division division NN 10_1101-2021_01_06_425581 83 18 events event NNS 10_1101-2021_01_06_425581 83 19 occur occur VBP 10_1101-2021_01_06_425581 83 20 every every DT 10_1101-2021_01_06_425581 83 21 ​n ​n NN 10_1101-2021_01_06_425581 83 22 minutes minute NNS 10_1101-2021_01_06_425581 83 23 ) ) -RRB- 10_1101-2021_01_06_425581 83 24 and and CC 10_1101-2021_01_06_425581 83 25 then then RB 10_1101-2021_01_06_425581 83 26 compare compare VB 10_1101-2021_01_06_425581 83 27 this this DT 10_1101-2021_01_06_425581 83 28 with with IN 10_1101-2021_01_06_425581 83 29 a a DT 10_1101-2021_01_06_425581 83 30 distribution distribution NN 10_1101-2021_01_06_425581 83 31 generated generate VBN 10_1101-2021_01_06_425581 83 32 using use VBG 10_1101-2021_01_06_425581 83 33 the the DT 10_1101-2021_01_06_425581 83 34 grand grand JJ 10_1101-2021_01_06_425581 83 35 function function NN 10_1101-2021_01_06_425581 83 36 in in IN 10_1101-2021_01_06_425581 83 37 SciLab SciLab NNP 10_1101-2021_01_06_425581 83 38 . . . 10_1101-2021_01_06_425581 84 1 For for IN 10_1101-2021_01_06_425581 84 2 the the DT 10_1101-2021_01_06_425581 84 3 Poisson Poisson NNP 10_1101-2021_01_06_425581 84 4 distribution distribution NN 10_1101-2021_01_06_425581 84 5 , , , 10_1101-2021_01_06_425581 84 6 we -PRON- PRP 10_1101-2021_01_06_425581 84 7 use use VBP 10_1101-2021_01_06_425581 84 8 a a DT 10_1101-2021_01_06_425581 84 9 𝜆 𝜆 NN 10_1101-2021_01_06_425581 84 10 = = SYM 10_1101-2021_01_06_425581 84 11 0.1 0.1 CD 10_1101-2021_01_06_425581 84 12 ( ( -LRB- 10_1101-2021_01_06_425581 84 13 except except IN 10_1101-2021_01_06_425581 84 14 where where WRB 10_1101-2021_01_06_425581 84 15 otherwise otherwise RB 10_1101-2021_01_06_425581 84 16 noted note VBN 10_1101-2021_01_06_425581 84 17 ) ) -RRB- 10_1101-2021_01_06_425581 84 18 , , , 10_1101-2021_01_06_425581 84 19 while while IN 10_1101-2021_01_06_425581 84 20 for for IN 10_1101-2021_01_06_425581 84 21 the the DT 10_1101-2021_01_06_425581 84 22 Binomial Binomial NNP 10_1101-2021_01_06_425581 84 23 distribution distribution NN 10_1101-2021_01_06_425581 84 24 , , , 10_1101-2021_01_06_425581 84 25 we -PRON- PRP 10_1101-2021_01_06_425581 84 26 use use VBP 10_1101-2021_01_06_425581 84 27 parameters parameter NNS 10_1101-2021_01_06_425581 84 28 ​N ​N NNP 10_1101-2021_01_06_425581 84 29 ​= ​= NNP 10_1101-2021_01_06_425581 84 30 1.0 1.0 CD 10_1101-2021_01_06_425581 84 31 and and CC 10_1101-2021_01_06_425581 84 32 ​p ​p NN 10_1101-2021_01_06_425581 84 33 ​= ​= NNP 10_1101-2021_01_06_425581 84 34 0.5 0.5 CD 10_1101-2021_01_06_425581 84 35 . . . 10_1101-2021_01_06_425581 85 1 This this DT 10_1101-2021_01_06_425581 85 2 produces produce VBZ 10_1101-2021_01_06_425581 85 3 intervals interval NNS 10_1101-2021_01_06_425581 85 4 that that WDT 10_1101-2021_01_06_425581 85 5 are be VBP 10_1101-2021_01_06_425581 85 6 variable variable JJ 10_1101-2021_01_06_425581 85 7 over over IN 10_1101-2021_01_06_425581 85 8 developmental developmental JJ 10_1101-2021_01_06_425581 85 9 time time NN 10_1101-2021_01_06_425581 85 10 . . . 10_1101-2021_01_06_425581 86 1 Results result NNS 10_1101-2021_01_06_425581 86 2 Our -PRON- PRP$ 10_1101-2021_01_06_425581 86 3 analysis analysis NN 10_1101-2021_01_06_425581 86 4 will will MD 10_1101-2021_01_06_425581 86 5 proceed proceed VB 10_1101-2021_01_06_425581 86 6 from from IN 10_1101-2021_01_06_425581 86 7 ​C. ​c. ADD 10_1101-2021_01_06_425581 87 1 elegans elegan NNS 10_1101-2021_01_06_425581 87 2 to to IN 10_1101-2021_01_06_425581 87 3 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 87 4 , , , 10_1101-2021_01_06_425581 87 5 to to IN 10_1101-2021_01_06_425581 87 6 a a DT 10_1101-2021_01_06_425581 87 7 comparison comparison NN 10_1101-2021_01_06_425581 87 8 of of IN 10_1101-2021_01_06_425581 87 9 the the DT 10_1101-2021_01_06_425581 87 10 two two CD 10_1101-2021_01_06_425581 87 11 species specie NNS 10_1101-2021_01_06_425581 87 12 , , , 10_1101-2021_01_06_425581 87 13 then then RB 10_1101-2021_01_06_425581 87 14 to to IN 10_1101-2021_01_06_425581 87 15 a a DT 10_1101-2021_01_06_425581 87 16 network network NN 10_1101-2021_01_06_425581 87 17 analysis analysis NN 10_1101-2021_01_06_425581 87 18 , , , 10_1101-2021_01_06_425581 87 19 and and CC 10_1101-2021_01_06_425581 87 20 finally finally RB 10_1101-2021_01_06_425581 87 21 to to IN 10_1101-2021_01_06_425581 87 22 a a DT 10_1101-2021_01_06_425581 87 23 simulation simulation NN 10_1101-2021_01_06_425581 87 24 of of IN 10_1101-2021_01_06_425581 87 25 cell cell NN 10_1101-2021_01_06_425581 87 26 division division NN 10_1101-2021_01_06_425581 87 27 in in IN 10_1101-2021_01_06_425581 87 28 development development NN 10_1101-2021_01_06_425581 87 29 . . . 10_1101-2021_01_06_425581 88 1 First first RB 10_1101-2021_01_06_425581 88 2 , , , 10_1101-2021_01_06_425581 88 3 we -PRON- PRP 10_1101-2021_01_06_425581 88 4 plot plot VBP 10_1101-2021_01_06_425581 88 5 the the DT 10_1101-2021_01_06_425581 88 6 developmental developmental JJ 10_1101-2021_01_06_425581 88 7 cell cell NN 10_1101-2021_01_06_425581 88 8 division division NN 10_1101-2021_01_06_425581 88 9 dynamics dynamic NNS 10_1101-2021_01_06_425581 88 10 in in IN 10_1101-2021_01_06_425581 88 11 ​C. ​C. NNP 10_1101-2021_01_06_425581 89 1 elegans elegans NNPS 10_1101-2021_01_06_425581 89 2 and and CC 10_1101-2021_01_06_425581 89 3 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 89 4 in in IN 10_1101-2021_01_06_425581 89 5 Figures Figures NNP 10_1101-2021_01_06_425581 89 6 1 1 CD 10_1101-2021_01_06_425581 89 7 and and CC 10_1101-2021_01_06_425581 89 8 3 3 CD 10_1101-2021_01_06_425581 89 9 , , , 10_1101-2021_01_06_425581 89 10 respectively respectively RB 10_1101-2021_01_06_425581 89 11 , , , 10_1101-2021_01_06_425581 89 12 and and CC 10_1101-2021_01_06_425581 89 13 cell cell NN 10_1101-2021_01_06_425581 89 14 differentiation differentiation NN 10_1101-2021_01_06_425581 89 15 in in IN 10_1101-2021_01_06_425581 89 16 ​C. ​c. ADD 10_1101-2021_01_06_425581 90 1 elegans elegans NNPS 10_1101-2021_01_06_425581 90 2 in in IN 10_1101-2021_01_06_425581 90 3 Figure Figure NNP 10_1101-2021_01_06_425581 90 4 1 1 CD 10_1101-2021_01_06_425581 90 5 . . . 10_1101-2021_01_06_425581 91 1 We -PRON- PRP 10_1101-2021_01_06_425581 91 2 then then RB 10_1101-2021_01_06_425581 91 3 examine examine VBP 10_1101-2021_01_06_425581 91 4 the the DT 10_1101-2021_01_06_425581 91 5 intervals interval NNS 10_1101-2021_01_06_425581 91 6 between between IN 10_1101-2021_01_06_425581 91 7 cell cell NN 10_1101-2021_01_06_425581 91 8 division division NN 10_1101-2021_01_06_425581 91 9 events event NNS 10_1101-2021_01_06_425581 91 10 ( ( -LRB- 10_1101-2021_01_06_425581 91 11 ​C. ​c. ADD 10_1101-2021_01_06_425581 92 1 elegans elegans NNPS 10_1101-2021_01_06_425581 92 2 ​ ​ NNP 10_1101-2021_01_06_425581 92 3 ) ) -RRB- 10_1101-2021_01_06_425581 92 4 and and CC 10_1101-2021_01_06_425581 92 5 relative relative JJ 10_1101-2021_01_06_425581 92 6 frequency frequency NN 10_1101-2021_01_06_425581 92 7 of of IN 10_1101-2021_01_06_425581 92 8 birth birth NN 10_1101-2021_01_06_425581 92 9 rates rate NNS 10_1101-2021_01_06_425581 92 10 across across IN 10_1101-2021_01_06_425581 92 11 development development NN 10_1101-2021_01_06_425581 92 12 ( ( -LRB- 10_1101-2021_01_06_425581 92 13 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 92 14 ) ) -RRB- 10_1101-2021_01_06_425581 92 15 in in IN 10_1101-2021_01_06_425581 92 16 Figures Figures NNP 10_1101-2021_01_06_425581 92 17 2 2 CD 10_1101-2021_01_06_425581 92 18 and and CC 10_1101-2021_01_06_425581 92 19 4 4 CD 10_1101-2021_01_06_425581 92 20 , , , 10_1101-2021_01_06_425581 92 21 respectively respectively RB 10_1101-2021_01_06_425581 92 22 . . . 10_1101-2021_01_06_425581 93 1 Focusing focus VBG 10_1101-2021_01_06_425581 93 2 on on IN 10_1101-2021_01_06_425581 93 3 the the DT 10_1101-2021_01_06_425581 93 4 peaks peak NNS 10_1101-2021_01_06_425581 93 5 ( ( -LRB- 10_1101-2021_01_06_425581 93 6 maximum maximum NN 10_1101-2021_01_06_425581 93 7 of of IN 10_1101-2021_01_06_425581 93 8 bursts burst NNS 10_1101-2021_01_06_425581 93 9 of of IN 10_1101-2021_01_06_425581 93 10 cell cell NN 10_1101-2021_01_06_425581 93 11 births birth NNS 10_1101-2021_01_06_425581 93 12 ) ) -RRB- 10_1101-2021_01_06_425581 93 13 shown show VBN 10_1101-2021_01_06_425581 93 14 in in IN 10_1101-2021_01_06_425581 93 15 Figures Figures NNP 10_1101-2021_01_06_425581 93 16 1 1 CD 10_1101-2021_01_06_425581 93 17 and and CC 10_1101-2021_01_06_425581 93 18 3 3 CD 10_1101-2021_01_06_425581 93 19 , , , 10_1101-2021_01_06_425581 93 20 Figure Figure NNP 10_1101-2021_01_06_425581 93 21 5 5 CD 10_1101-2021_01_06_425581 93 22 shows show VBZ 10_1101-2021_01_06_425581 93 23 the the DT 10_1101-2021_01_06_425581 93 24 distribution distribution NN 10_1101-2021_01_06_425581 93 25 of of IN 10_1101-2021_01_06_425581 93 26 intervals interval NNS 10_1101-2021_01_06_425581 93 27 between between IN 10_1101-2021_01_06_425581 93 28 peak peak NN 10_1101-2021_01_06_425581 93 29 values value NNS 10_1101-2021_01_06_425581 93 30 for for IN 10_1101-2021_01_06_425581 93 31 ​C. ​c. ADD 10_1101-2021_01_06_425581 94 1 elegans elegans NNPS 10_1101-2021_01_06_425581 94 2 and and CC 10_1101-2021_01_06_425581 94 3 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 94 4 . . . 10_1101-2021_01_06_425581 95 1 Figure figure NN 10_1101-2021_01_06_425581 95 2 6 6 CD 10_1101-2021_01_06_425581 95 3 helps help VBZ 10_1101-2021_01_06_425581 95 4 us -PRON- PRP 10_1101-2021_01_06_425581 95 5 extend extend VB 10_1101-2021_01_06_425581 95 6 this this DT 10_1101-2021_01_06_425581 95 7 finding finding NN 10_1101-2021_01_06_425581 95 8 from from IN 10_1101-2021_01_06_425581 95 9 temporal temporal JJ 10_1101-2021_01_06_425581 95 10 dynamics dynamic NNS 10_1101-2021_01_06_425581 95 11 to to TO 10_1101-2021_01_06_425581 95 12 connectivity connectivity VB 10_1101-2021_01_06_425581 95 13 between between IN 10_1101-2021_01_06_425581 95 14 cells cell NNS 10_1101-2021_01_06_425581 95 15 and and CC 10_1101-2021_01_06_425581 95 16 spatial spatial JJ 10_1101-2021_01_06_425581 95 17 distributions distribution NNS 10_1101-2021_01_06_425581 95 18 of of IN 10_1101-2021_01_06_425581 95 19 newly newly RB 10_1101-2021_01_06_425581 95 20 - - HYPH 10_1101-2021_01_06_425581 95 21 born bear VBN 10_1101-2021_01_06_425581 95 22 cells cell NNS 10_1101-2021_01_06_425581 95 23 . . . 10_1101-2021_01_06_425581 96 1 We -PRON- PRP 10_1101-2021_01_06_425581 96 2 conclude conclude VBP 10_1101-2021_01_06_425581 96 3 with with IN 10_1101-2021_01_06_425581 96 4 an an DT 10_1101-2021_01_06_425581 96 5 investigation investigation NN 10_1101-2021_01_06_425581 96 6 of of IN 10_1101-2021_01_06_425581 96 7 how how WRB 10_1101-2021_01_06_425581 96 8 the the DT 10_1101-2021_01_06_425581 96 9 intervals interval NNS 10_1101-2021_01_06_425581 96 10 found find VBD 10_1101-2021_01_06_425581 96 11 between between IN 10_1101-2021_01_06_425581 96 12 cell cell NN 10_1101-2021_01_06_425581 96 13 divisions division NNS 10_1101-2021_01_06_425581 96 14 can can MD 10_1101-2021_01_06_425581 96 15 be be VB 10_1101-2021_01_06_425581 96 16 modeled model VBN 10_1101-2021_01_06_425581 96 17 using use VBG 10_1101-2021_01_06_425581 96 18 various various JJ 10_1101-2021_01_06_425581 96 19 statistical statistical JJ 10_1101-2021_01_06_425581 96 20 distributions distribution NNS 10_1101-2021_01_06_425581 96 21 and and CC 10_1101-2021_01_06_425581 96 22 is be VBZ 10_1101-2021_01_06_425581 96 23 shown show VBN 10_1101-2021_01_06_425581 96 24 in in IN 10_1101-2021_01_06_425581 96 25 Figure Figure NNP 10_1101-2021_01_06_425581 96 26 7 7 CD 10_1101-2021_01_06_425581 96 27 . . . 10_1101-2021_01_06_425581 97 1 These these DT 10_1101-2021_01_06_425581 97 2 simulations simulation NNS 10_1101-2021_01_06_425581 97 3 ( ( -LRB- 10_1101-2021_01_06_425581 97 4 called call VBN 10_1101-2021_01_06_425581 97 5 numeric numeric JJ 10_1101-2021_01_06_425581 97 6 embryos embryo NNS 10_1101-2021_01_06_425581 97 7 ) ) -RRB- 10_1101-2021_01_06_425581 97 8 can can MD 10_1101-2021_01_06_425581 97 9 reveal reveal VB 10_1101-2021_01_06_425581 97 10 properties property NNS 10_1101-2021_01_06_425581 97 11 related relate VBN 10_1101-2021_01_06_425581 97 12 to to IN 10_1101-2021_01_06_425581 97 13 the the DT 10_1101-2021_01_06_425581 97 14 speed speed NN 10_1101-2021_01_06_425581 97 15 of of IN 10_1101-2021_01_06_425581 97 16 development development NN 10_1101-2021_01_06_425581 97 17 , , , 10_1101-2021_01_06_425581 97 18 particularly particularly RB 10_1101-2021_01_06_425581 97 19 the the DT 10_1101-2021_01_06_425581 97 20 linear linear NN 10_1101-2021_01_06_425581 97 21 and and CC 10_1101-2021_01_06_425581 97 22 nonlinear nonlinear JJ 10_1101-2021_01_06_425581 97 23 accumulation accumulation NN 10_1101-2021_01_06_425581 97 24 of of IN 10_1101-2021_01_06_425581 97 25 cells cell NNS 10_1101-2021_01_06_425581 97 26 . . . 10_1101-2021_01_06_425581 98 1 Caenorhabditis caenorhabditis NN 10_1101-2021_01_06_425581 98 2 elegans elegan NNS 10_1101-2021_01_06_425581 98 3 ​ ​ JJ 10_1101-2021_01_06_425581 98 4 Example Example NNP 10_1101-2021_01_06_425581 98 5 To to TO 10_1101-2021_01_06_425581 98 6 understand understand VB 10_1101-2021_01_06_425581 98 7 the the DT 10_1101-2021_01_06_425581 98 8 temporal temporal JJ 10_1101-2021_01_06_425581 98 9 nature nature NN 10_1101-2021_01_06_425581 98 10 of of IN 10_1101-2021_01_06_425581 98 11 cell cell NN 10_1101-2021_01_06_425581 98 12 division division NN 10_1101-2021_01_06_425581 98 13 and and CC 10_1101-2021_01_06_425581 98 14 differentiation differentiation NN 10_1101-2021_01_06_425581 98 15 , , , 10_1101-2021_01_06_425581 98 16 we -PRON- PRP 10_1101-2021_01_06_425581 98 17 start start VBP 10_1101-2021_01_06_425581 98 18 by by IN 10_1101-2021_01_06_425581 98 19 looking look VBG 10_1101-2021_01_06_425581 98 20 at at IN 10_1101-2021_01_06_425581 98 21 patterns pattern NNS 10_1101-2021_01_06_425581 98 22 in in IN 10_1101-2021_01_06_425581 98 23 ​C. ​C. NNP 10_1101-2021_01_06_425581 99 1 elegans elegans NNPS 10_1101-2021_01_06_425581 99 2 development development NN 10_1101-2021_01_06_425581 99 3 over over IN 10_1101-2021_01_06_425581 99 4 time time NN 10_1101-2021_01_06_425581 99 5 . . . 10_1101-2021_01_06_425581 100 1 Figure figure NN 10_1101-2021_01_06_425581 100 2 1 1 CD 10_1101-2021_01_06_425581 100 3 shows show VBZ 10_1101-2021_01_06_425581 100 4 a a DT 10_1101-2021_01_06_425581 100 5 time time NN 10_1101-2021_01_06_425581 100 6 series series NN 10_1101-2021_01_06_425581 100 7 of of IN 10_1101-2021_01_06_425581 100 8 such such JJ 10_1101-2021_01_06_425581 100 9 events event NNS 10_1101-2021_01_06_425581 100 10 from from IN 10_1101-2021_01_06_425581 100 11 zygote zygote NNP 10_1101-2021_01_06_425581 100 12 to to IN 10_1101-2021_01_06_425581 100 13 adulthood adulthood NN 10_1101-2021_01_06_425581 100 14 . . . 10_1101-2021_01_06_425581 101 1 We -PRON- PRP 10_1101-2021_01_06_425581 101 2 are be VBP 10_1101-2021_01_06_425581 101 3 particularly particularly RB 10_1101-2021_01_06_425581 101 4 interested interested JJ 10_1101-2021_01_06_425581 101 5 in in IN 10_1101-2021_01_06_425581 101 6 potential potential JJ 10_1101-2021_01_06_425581 101 7 spikes spike NNS 10_1101-2021_01_06_425581 101 8 or or CC 10_1101-2021_01_06_425581 101 9 bursts burst NNS 10_1101-2021_01_06_425581 101 10 of of IN 10_1101-2021_01_06_425581 101 11 events event NNS 10_1101-2021_01_06_425581 101 12 in in IN 10_1101-2021_01_06_425581 101 13 a a DT 10_1101-2021_01_06_425581 101 14 short short JJ 10_1101-2021_01_06_425581 101 15 period period NN 10_1101-2021_01_06_425581 101 16 of of IN 10_1101-2021_01_06_425581 101 17 time time NN 10_1101-2021_01_06_425581 101 18 . . . 10_1101-2021_01_06_425581 102 1 Figure figure NN 10_1101-2021_01_06_425581 102 2 1 1 CD 10_1101-2021_01_06_425581 102 3 shows show VBZ 10_1101-2021_01_06_425581 102 4 the the DT 10_1101-2021_01_06_425581 102 5 fluctuations fluctuation NNS 10_1101-2021_01_06_425581 102 6 in in IN 10_1101-2021_01_06_425581 102 7 cell cell NN 10_1101-2021_01_06_425581 102 8 divisions division NNS 10_1101-2021_01_06_425581 102 9 in in IN 10_1101-2021_01_06_425581 102 10 embryonic embryonic JJ 10_1101-2021_01_06_425581 102 11 division division NN 10_1101-2021_01_06_425581 102 12 ( ( -LRB- 10_1101-2021_01_06_425581 102 13 Figure Figure NNP 10_1101-2021_01_06_425581 102 14 1 1 CD 10_1101-2021_01_06_425581 102 15 , , , 10_1101-2021_01_06_425581 102 16 top top NN 10_1101-2021_01_06_425581 102 17 ) ) -RRB- 10_1101-2021_01_06_425581 102 18 and and CC 10_1101-2021_01_06_425581 102 19 differentiation differentiation NN 10_1101-2021_01_06_425581 102 20 ( ( -LRB- 10_1101-2021_01_06_425581 102 21 Figure figure NN 10_1101-2021_01_06_425581 102 22 1 1 CD 10_1101-2021_01_06_425581 102 23 , , , 10_1101-2021_01_06_425581 102 24 bottom bottom NN 10_1101-2021_01_06_425581 102 25 ) ) -RRB- 10_1101-2021_01_06_425581 102 26 events event NNS 10_1101-2021_01_06_425581 102 27 . . . 10_1101-2021_01_06_425581 103 1 Differentiation differentiation NN 10_1101-2021_01_06_425581 103 2 events event NNS 10_1101-2021_01_06_425581 103 3 occurring occur VBG 10_1101-2021_01_06_425581 103 4 after after IN 10_1101-2021_01_06_425581 103 5 1000 1000 CD 10_1101-2021_01_06_425581 103 6 minutes minute NNS 10_1101-2021_01_06_425581 103 7 of of IN 10_1101-2021_01_06_425581 103 8 developmental developmental JJ 10_1101-2021_01_06_425581 103 9 time time NN 10_1101-2021_01_06_425581 103 10 ( ( -LRB- 10_1101-2021_01_06_425581 103 11 postembryonic postembryonic JJ 10_1101-2021_01_06_425581 103 12 development development NN 10_1101-2021_01_06_425581 103 13 ) ) -RRB- 10_1101-2021_01_06_425581 103 14 occur occur VBP 10_1101-2021_01_06_425581 103 15 in in IN 10_1101-2021_01_06_425581 103 16 a a DT 10_1101-2021_01_06_425581 103 17 long long JJ 10_1101-2021_01_06_425581 103 18 series series NN 10_1101-2021_01_06_425581 103 19 of of IN 10_1101-2021_01_06_425581 103 20 bursts burst NNS 10_1101-2021_01_06_425581 103 21 , , , 10_1101-2021_01_06_425581 103 22 likely likely RB 10_1101-2021_01_06_425581 103 23 corresponding correspond VBG 10_1101-2021_01_06_425581 103 24 to to IN 10_1101-2021_01_06_425581 103 25 the the DT 10_1101-2021_01_06_425581 103 26 differentiation differentiation NN 10_1101-2021_01_06_425581 103 27 of of IN 10_1101-2021_01_06_425581 103 28 seam seam NN 10_1101-2021_01_06_425581 103 29 cells cell NNS 10_1101-2021_01_06_425581 103 30 . . . 10_1101-2021_01_06_425581 104 1 This this DT 10_1101-2021_01_06_425581 104 2 can can MD 10_1101-2021_01_06_425581 104 3 be be VB 10_1101-2021_01_06_425581 104 4 contrasted contrast VBN 10_1101-2021_01_06_425581 104 5 with with IN 10_1101-2021_01_06_425581 104 6 the the DT 10_1101-2021_01_06_425581 104 7 burstiness burstiness NN 10_1101-2021_01_06_425581 104 8 that that WDT 10_1101-2021_01_06_425581 104 9 occurs occur VBZ 10_1101-2021_01_06_425581 104 10 in in IN 10_1101-2021_01_06_425581 104 11 embryonic embryonic JJ 10_1101-2021_01_06_425581 104 12 development development NN 10_1101-2021_01_06_425581 104 13 , , , 10_1101-2021_01_06_425581 104 14 which which WDT 10_1101-2021_01_06_425581 104 15 is be VBZ 10_1101-2021_01_06_425581 104 16 similar similar JJ 10_1101-2021_01_06_425581 104 17 to to IN 10_1101-2021_01_06_425581 104 18 the the DT 10_1101-2021_01_06_425581 104 19 burstiness burstiness NN 10_1101-2021_01_06_425581 104 20 of of IN 10_1101-2021_01_06_425581 104 21 division division NN 10_1101-2021_01_06_425581 104 22 events event NNS 10_1101-2021_01_06_425581 104 23 . . . 10_1101-2021_01_06_425581 105 1 Figure figure NN 10_1101-2021_01_06_425581 105 2 2 2 CD 10_1101-2021_01_06_425581 105 3 shows show VBZ 10_1101-2021_01_06_425581 105 4 the the DT 10_1101-2021_01_06_425581 105 5 intervals interval NNS 10_1101-2021_01_06_425581 105 6 between between IN 10_1101-2021_01_06_425581 105 7 cell cell NN 10_1101-2021_01_06_425581 105 8 division division NN 10_1101-2021_01_06_425581 105 9 events event NNS 10_1101-2021_01_06_425581 105 10 across across IN 10_1101-2021_01_06_425581 105 11 embryonic embryonic JJ 10_1101-2021_01_06_425581 105 12 development development NN 10_1101-2021_01_06_425581 105 13 in in IN 10_1101-2021_01_06_425581 105 14 ​C. ​c. ADD 10_1101-2021_01_06_425581 106 1 elegans elegans NNPS 10_1101-2021_01_06_425581 106 2 ​. ​. NNP 10_1101-2021_01_06_425581 107 1 This this DT 10_1101-2021_01_06_425581 107 2 plot plot NN 10_1101-2021_01_06_425581 107 3 confirms confirm VBZ 10_1101-2021_01_06_425581 107 4 an an DT 10_1101-2021_01_06_425581 107 5 exponential exponential JJ 10_1101-2021_01_06_425581 107 6 distribution distribution NN 10_1101-2021_01_06_425581 107 7 with with IN 10_1101-2021_01_06_425581 107 8 a a DT 10_1101-2021_01_06_425581 107 9 long long JJ 10_1101-2021_01_06_425581 107 10 tail tail NN 10_1101-2021_01_06_425581 107 11 , , , 10_1101-2021_01_06_425581 107 12 presumably presumably RB 10_1101-2021_01_06_425581 107 13 representing represent VBG 10_1101-2021_01_06_425581 107 14 intervals interval NNS 10_1101-2021_01_06_425581 107 15 in in IN 10_1101-2021_01_06_425581 107 16 postembryonic postembryonic JJ 10_1101-2021_01_06_425581 107 17 development development NN 10_1101-2021_01_06_425581 107 18 . . . 10_1101-2021_01_06_425581 108 1 Yet yet RB 10_1101-2021_01_06_425581 108 2 this this DT 10_1101-2021_01_06_425581 108 3 plot plot NN 10_1101-2021_01_06_425581 108 4 is be VBZ 10_1101-2021_01_06_425581 108 5 also also RB 10_1101-2021_01_06_425581 108 6 sparse sparse JJ 10_1101-2021_01_06_425581 108 7 , , , 10_1101-2021_01_06_425581 108 8 yielding yield VBG 10_1101-2021_01_06_425581 108 9 only only RB 10_1101-2021_01_06_425581 108 10 12 12 CD 10_1101-2021_01_06_425581 108 11 distinct distinct JJ 10_1101-2021_01_06_425581 108 12 intervals interval NNS 10_1101-2021_01_06_425581 108 13 of of IN 10_1101-2021_01_06_425581 108 14 cell cell NN 10_1101-2021_01_06_425581 108 15 division division NN 10_1101-2021_01_06_425581 108 16 throughout throughout IN 10_1101-2021_01_06_425581 108 17 all all DT 10_1101-2021_01_06_425581 108 18 of of IN 10_1101-2021_01_06_425581 108 19 ​C. ​C. NNP 10_1101-2021_01_06_425581 109 1 elegans elegans NNPS 10_1101-2021_01_06_425581 109 2 development development NN 10_1101-2021_01_06_425581 109 3 . . . 10_1101-2021_01_06_425581 110 1 This this DT 10_1101-2021_01_06_425581 110 2 is be VBZ 10_1101-2021_01_06_425581 110 3 likely likely JJ 10_1101-2021_01_06_425581 110 4 due due IN 10_1101-2021_01_06_425581 110 5 to to IN 10_1101-2021_01_06_425581 110 6 the the DT 10_1101-2021_01_06_425581 110 7 deterministic deterministic JJ 10_1101-2021_01_06_425581 110 8 nature nature NN 10_1101-2021_01_06_425581 110 9 of of IN 10_1101-2021_01_06_425581 110 10 ​C. ​C. NNP 10_1101-2021_01_06_425581 111 1 elegans elegans NNPS 10_1101-2021_01_06_425581 111 2 development development NN 10_1101-2021_01_06_425581 111 3 along along IN 10_1101-2021_01_06_425581 111 4 with with IN 10_1101-2021_01_06_425581 111 5 the the DT 10_1101-2021_01_06_425581 111 6 relatively relatively RB 10_1101-2021_01_06_425581 111 7 small small JJ 10_1101-2021_01_06_425581 111 8 number number NN 10_1101-2021_01_06_425581 111 9 of of IN 10_1101-2021_01_06_425581 111 10 cells cell NNS 10_1101-2021_01_06_425581 111 11 . . . 10_1101-2021_01_06_425581 112 1 Supplemental supplemental JJ 10_1101-2021_01_06_425581 112 2 Figures figure NNS 10_1101-2021_01_06_425581 112 3 2 2 CD 10_1101-2021_01_06_425581 112 4 and and CC 10_1101-2021_01_06_425581 112 5 3 3 CD 10_1101-2021_01_06_425581 112 6 reveal reveal VB 10_1101-2021_01_06_425581 112 7 the the DT 10_1101-2021_01_06_425581 112 8 power power NN 10_1101-2021_01_06_425581 112 9 spectrum spectrum NN 10_1101-2021_01_06_425581 112 10 for for IN 10_1101-2021_01_06_425581 112 11 cell cell NN 10_1101-2021_01_06_425581 112 12 division division NN 10_1101-2021_01_06_425581 112 13 and and CC 10_1101-2021_01_06_425581 112 14 cell cell NN 10_1101-2021_01_06_425581 112 15 differentiation differentiation NN 10_1101-2021_01_06_425581 112 16 in in IN 10_1101-2021_01_06_425581 112 17 ​C. ​c. ADD 10_1101-2021_01_06_425581 113 1 elegans​ elegans​ UH 10_1101-2021_01_06_425581 113 2 , , , 10_1101-2021_01_06_425581 113 3 respectively respectively RB 10_1101-2021_01_06_425581 113 4 . . . 10_1101-2021_01_06_425581 114 1 To to TO 10_1101-2021_01_06_425581 114 2 compare compare VB 10_1101-2021_01_06_425581 114 3 , , , 10_1101-2021_01_06_425581 114 4 contrast contrast NN 10_1101-2021_01_06_425581 114 5 , , , 10_1101-2021_01_06_425581 114 6 and and CC 10_1101-2021_01_06_425581 114 7 understand understand VB 10_1101-2021_01_06_425581 114 8 these these DT 10_1101-2021_01_06_425581 114 9 trends trend NNS 10_1101-2021_01_06_425581 114 10 further far RBR 10_1101-2021_01_06_425581 114 11 , , , 10_1101-2021_01_06_425581 114 12 we -PRON- PRP 10_1101-2021_01_06_425581 114 13 now now RB 10_1101-2021_01_06_425581 114 14 turn turn VBP 10_1101-2021_01_06_425581 114 15 to to IN 10_1101-2021_01_06_425581 114 16 the the DT 10_1101-2021_01_06_425581 114 17 embryonic embryonic JJ 10_1101-2021_01_06_425581 114 18 development development NN 10_1101-2021_01_06_425581 114 19 of of IN 10_1101-2021_01_06_425581 114 20 the the DT 10_1101-2021_01_06_425581 114 21 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 114 22 ( ( -LRB- 10_1101-2021_01_06_425581 114 23 ​D. ​d. ADD 10_1101-2021_01_06_425581 115 1 rerio​ rerio​ NNP 10_1101-2021_01_06_425581 115 2 ) ) -RRB- 10_1101-2021_01_06_425581 115 3 . . . 10_1101-2021_01_06_425581 116 1 3 3 LS 10_1101-2021_01_06_425581 116 2 .CC .CC : 10_1101-2021_01_06_425581 116 3 - - HYPH 10_1101-2021_01_06_425581 116 4 BY BY NNP 10_1101-2021_01_06_425581 116 5 - - HYPH 10_1101-2021_01_06_425581 116 6 NC NC NNP 10_1101-2021_01_06_425581 116 7 4.0 4.0 CD 10_1101-2021_01_06_425581 116 8 International international JJ 10_1101-2021_01_06_425581 116 9 licensemade licensemade NN 10_1101-2021_01_06_425581 116 10 available available JJ 10_1101-2021_01_06_425581 116 11 under under IN 10_1101-2021_01_06_425581 116 12 a a DT 10_1101-2021_01_06_425581 116 13 ( ( -LRB- 10_1101-2021_01_06_425581 116 14 which which WDT 10_1101-2021_01_06_425581 116 15 was be VBD 10_1101-2021_01_06_425581 116 16 not not RB 10_1101-2021_01_06_425581 116 17 certified certify VBN 10_1101-2021_01_06_425581 116 18 by by IN 10_1101-2021_01_06_425581 116 19 peer peer NN 10_1101-2021_01_06_425581 116 20 review review NN 10_1101-2021_01_06_425581 116 21 ) ) -RRB- 10_1101-2021_01_06_425581 116 22 is be VBZ 10_1101-2021_01_06_425581 116 23 the the DT 10_1101-2021_01_06_425581 116 24 author author NN 10_1101-2021_01_06_425581 116 25 / / SYM 10_1101-2021_01_06_425581 116 26 funder funder NN 10_1101-2021_01_06_425581 116 27 , , , 10_1101-2021_01_06_425581 116 28 who who WP 10_1101-2021_01_06_425581 116 29 has have VBZ 10_1101-2021_01_06_425581 116 30 granted grant VBN 10_1101-2021_01_06_425581 116 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 116 32 a a DT 10_1101-2021_01_06_425581 116 33 license license NN 10_1101-2021_01_06_425581 116 34 to to TO 10_1101-2021_01_06_425581 116 35 display display VB 10_1101-2021_01_06_425581 116 36 the the DT 10_1101-2021_01_06_425581 116 37 preprint preprint NN 10_1101-2021_01_06_425581 116 38 in in IN 10_1101-2021_01_06_425581 116 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 116 40 . . . 10_1101-2021_01_06_425581 117 1 It -PRON- PRP 10_1101-2021_01_06_425581 117 2 is be VBZ 10_1101-2021_01_06_425581 117 3 The the DT 10_1101-2021_01_06_425581 117 4 copyright copyright NN 10_1101-2021_01_06_425581 117 5 holder holder NN 10_1101-2021_01_06_425581 117 6 for for IN 10_1101-2021_01_06_425581 117 7 this this DT 10_1101-2021_01_06_425581 117 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 117 9 version version NN 10_1101-2021_01_06_425581 117 10 posted post VBD 10_1101-2021_01_06_425581 117 11 January January NNP 10_1101-2021_01_06_425581 117 12 8 8 CD 10_1101-2021_01_06_425581 117 13 , , , 10_1101-2021_01_06_425581 117 14 2021 2021 CD 10_1101-2021_01_06_425581 117 15 . . . 10_1101-2021_01_06_425581 117 16 ; ; : 10_1101-2021_01_06_425581 117 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 117 18 : : : 10_1101-2021_01_06_425581 117 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 117 20 preprint preprint NN 10_1101-2021_01_06_425581 117 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 117 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 117 23 Figure Figure NNP 10_1101-2021_01_06_425581 117 24 1 1 CD 10_1101-2021_01_06_425581 117 25 . . . 10_1101-2021_01_06_425581 118 1 Developmental developmental JJ 10_1101-2021_01_06_425581 118 2 cell cell NN 10_1101-2021_01_06_425581 118 3 births birth NNS 10_1101-2021_01_06_425581 118 4 in in IN 10_1101-2021_01_06_425581 118 5 the the DT 10_1101-2021_01_06_425581 118 6 nematode nematode NN 10_1101-2021_01_06_425581 118 7 ​C. ​C. . 10_1101-2021_01_06_425581 119 1 elegans​. elegans​. XX 10_1101-2021_01_06_425581 120 1 Cell cell NN 10_1101-2021_01_06_425581 120 2 divisions division NNS 10_1101-2021_01_06_425581 120 3 occur occur VBP 10_1101-2021_01_06_425581 120 4 according accord VBG 10_1101-2021_01_06_425581 120 5 to to IN 10_1101-2021_01_06_425581 120 6 developmental developmental JJ 10_1101-2021_01_06_425581 120 7 time time NN 10_1101-2021_01_06_425581 120 8 ( ( -LRB- 10_1101-2021_01_06_425581 120 9 minutes minute NNS 10_1101-2021_01_06_425581 120 10 ) ) -RRB- 10_1101-2021_01_06_425581 120 11 . . . 10_1101-2021_01_06_425581 121 1 The the DT 10_1101-2021_01_06_425581 121 2 timeline timeline NN 10_1101-2021_01_06_425581 121 3 ranges range VBZ 10_1101-2021_01_06_425581 121 4 from from IN 10_1101-2021_01_06_425581 121 5 fertilized fertilize VBN 10_1101-2021_01_06_425581 121 6 egg egg NN 10_1101-2021_01_06_425581 121 7 ( ( -LRB- 10_1101-2021_01_06_425581 121 8 zygote zygote NNP 10_1101-2021_01_06_425581 121 9 ) ) -RRB- 10_1101-2021_01_06_425581 121 10 to to IN 10_1101-2021_01_06_425581 121 11 adulthood adulthood NN 10_1101-2021_01_06_425581 121 12 . . . 10_1101-2021_01_06_425581 122 1 Embryonic embryonic JJ 10_1101-2021_01_06_425581 122 2 division division NN 10_1101-2021_01_06_425581 122 3 events event NNS 10_1101-2021_01_06_425581 122 4 ( ( -LRB- 10_1101-2021_01_06_425581 122 5 blue blue NNP 10_1101-2021_01_06_425581 122 6 ) ) -RRB- 10_1101-2021_01_06_425581 122 7 , , , 10_1101-2021_01_06_425581 122 8 differentiation differentiation NN 10_1101-2021_01_06_425581 122 9 events event NNS 10_1101-2021_01_06_425581 122 10 ( ( -LRB- 10_1101-2021_01_06_425581 122 11 red red NNP 10_1101-2021_01_06_425581 122 12 ) ) -RRB- 10_1101-2021_01_06_425581 122 13 . . . 10_1101-2021_01_06_425581 123 1 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 123 2 In in IN 10_1101-2021_01_06_425581 123 3 Figure figure NN 10_1101-2021_01_06_425581 123 4 3 3 CD 10_1101-2021_01_06_425581 123 5 ( ( -LRB- 10_1101-2021_01_06_425581 123 6 top top NN 10_1101-2021_01_06_425581 123 7 ) ) -RRB- 10_1101-2021_01_06_425581 123 8 , , , 10_1101-2021_01_06_425581 123 9 we -PRON- PRP 10_1101-2021_01_06_425581 123 10 observe observe VBP 10_1101-2021_01_06_425581 123 11 six six CD 10_1101-2021_01_06_425581 123 12 regular regular JJ 10_1101-2021_01_06_425581 123 13 busts bust NNS 10_1101-2021_01_06_425581 123 14 of of IN 10_1101-2021_01_06_425581 123 15 cell cell NN 10_1101-2021_01_06_425581 123 16 division division NN 10_1101-2021_01_06_425581 123 17 , , , 10_1101-2021_01_06_425581 123 18 followed follow VBN 10_1101-2021_01_06_425581 123 19 by by IN 10_1101-2021_01_06_425581 123 20 aperiodic aperiodic JJ 10_1101-2021_01_06_425581 123 21 cell cell NN 10_1101-2021_01_06_425581 123 22 division division NN 10_1101-2021_01_06_425581 123 23 behavior behavior NN 10_1101-2021_01_06_425581 123 24 . . . 10_1101-2021_01_06_425581 124 1 This this DT 10_1101-2021_01_06_425581 124 2 transition transition NN 10_1101-2021_01_06_425581 124 3 in in IN 10_1101-2021_01_06_425581 124 4 periodicity periodicity NN 10_1101-2021_01_06_425581 124 5 is be VBZ 10_1101-2021_01_06_425581 124 6 observed observe VBN 10_1101-2021_01_06_425581 124 7 after after IN 10_1101-2021_01_06_425581 124 8 the the DT 10_1101-2021_01_06_425581 124 9 embryo embryo NN 10_1101-2021_01_06_425581 124 10 reaches reach VBZ 10_1101-2021_01_06_425581 124 11 1529 1529 CD 10_1101-2021_01_06_425581 124 12 cells cell NNS 10_1101-2021_01_06_425581 124 13 in in IN 10_1101-2021_01_06_425581 124 14 size size NN 10_1101-2021_01_06_425581 124 15 ( ( -LRB- 10_1101-2021_01_06_425581 124 16 Figure figure NN 10_1101-2021_01_06_425581 124 17 3 3 CD 10_1101-2021_01_06_425581 124 18 , , , 10_1101-2021_01_06_425581 124 19 bottom bottom NN 10_1101-2021_01_06_425581 124 20 ) ) -RRB- 10_1101-2021_01_06_425581 124 21 . . . 10_1101-2021_01_06_425581 125 1 We -PRON- PRP 10_1101-2021_01_06_425581 125 2 do do VBP 10_1101-2021_01_06_425581 125 3 not not RB 10_1101-2021_01_06_425581 125 4 observe observe VB 10_1101-2021_01_06_425581 125 5 this this DT 10_1101-2021_01_06_425581 125 6 in in IN 10_1101-2021_01_06_425581 125 7 ​C. ​c. ADD 10_1101-2021_01_06_425581 126 1 elegans elegans NNP 10_1101-2021_01_06_425581 126 2 embryos embryo NNS 10_1101-2021_01_06_425581 126 3 , , , 10_1101-2021_01_06_425581 126 4 and and CC 10_1101-2021_01_06_425581 126 5 may may MD 10_1101-2021_01_06_425581 126 6 have have VB 10_1101-2021_01_06_425581 126 7 to to TO 10_1101-2021_01_06_425581 126 8 do do VB 10_1101-2021_01_06_425581 126 9 with with IN 10_1101-2021_01_06_425581 126 10 the the DT 10_1101-2021_01_06_425581 126 11 more more RBR 10_1101-2021_01_06_425581 126 12 regulative regulative JJ 10_1101-2021_01_06_425581 126 13 nature nature NN 10_1101-2021_01_06_425581 126 14 of of IN 10_1101-2021_01_06_425581 126 15 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 126 16 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 126 17 [ [ -LRB- 10_1101-2021_01_06_425581 126 18 19 19 CD 10_1101-2021_01_06_425581 126 19 ] ] -RRB- 10_1101-2021_01_06_425581 126 20 . . . 10_1101-2021_01_06_425581 127 1 Changes change NNS 10_1101-2021_01_06_425581 127 2 in in IN 10_1101-2021_01_06_425581 127 3 periodicity periodicity NN 10_1101-2021_01_06_425581 127 4 may may MD 10_1101-2021_01_06_425581 127 5 also also RB 10_1101-2021_01_06_425581 127 6 have have VB 10_1101-2021_01_06_425581 127 7 to to TO 10_1101-2021_01_06_425581 127 8 do do VB 10_1101-2021_01_06_425581 127 9 with with IN 10_1101-2021_01_06_425581 127 10 the the DT 10_1101-2021_01_06_425581 127 11 establishment establishment NN 10_1101-2021_01_06_425581 127 12 of of IN 10_1101-2021_01_06_425581 127 13 spatial spatial JJ 10_1101-2021_01_06_425581 127 14 differentiation differentiation NN 10_1101-2021_01_06_425581 127 15 beyond beyond IN 10_1101-2021_01_06_425581 127 16 the the DT 10_1101-2021_01_06_425581 127 17 axial axial JJ 10_1101-2021_01_06_425581 127 18 variability variability NN 10_1101-2021_01_06_425581 127 19 observed observe VBN 10_1101-2021_01_06_425581 127 20 in in IN 10_1101-2021_01_06_425581 127 21 ​C. ​c. ADD 10_1101-2021_01_06_425581 128 1 elegans​. elegans​. XX 10_1101-2021_01_06_425581 129 1 To to TO 10_1101-2021_01_06_425581 129 2 better well RBR 10_1101-2021_01_06_425581 129 3 understand understand VB 10_1101-2021_01_06_425581 129 4 the the DT 10_1101-2021_01_06_425581 129 5 nature nature NN 10_1101-2021_01_06_425581 129 6 of of IN 10_1101-2021_01_06_425581 129 7 periodicity periodicity NN 10_1101-2021_01_06_425581 129 8 in in IN 10_1101-2021_01_06_425581 129 9 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 129 10 , , , 10_1101-2021_01_06_425581 129 11 we -PRON- PRP 10_1101-2021_01_06_425581 129 12 examined examine VBD 10_1101-2021_01_06_425581 129 13 the the DT 10_1101-2021_01_06_425581 129 14 distribution distribution NN 10_1101-2021_01_06_425581 129 15 of of IN 10_1101-2021_01_06_425581 129 16 intervals interval NNS 10_1101-2021_01_06_425581 129 17 between between IN 10_1101-2021_01_06_425581 129 18 birth birth NN 10_1101-2021_01_06_425581 129 19 times time NNS 10_1101-2021_01_06_425581 129 20 . . . 10_1101-2021_01_06_425581 130 1 Figure figure NN 10_1101-2021_01_06_425581 130 2 4 4 CD 10_1101-2021_01_06_425581 130 3 and and CC 10_1101-2021_01_06_425581 130 4 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 130 5 Figure Figure NNP 10_1101-2021_01_06_425581 130 6 4 4 CD 10_1101-2021_01_06_425581 130 7 confirms confirm VBZ 10_1101-2021_01_06_425581 130 8 the the DT 10_1101-2021_01_06_425581 130 9 bursty bursty JJ 10_1101-2021_01_06_425581 130 10 nature nature NN 10_1101-2021_01_06_425581 130 11 of of IN 10_1101-2021_01_06_425581 130 12 cell cell NN 10_1101-2021_01_06_425581 130 13 division division NN 10_1101-2021_01_06_425581 130 14 in in IN 10_1101-2021_01_06_425581 130 15 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 130 16 , , , 10_1101-2021_01_06_425581 130 17 in in IN 10_1101-2021_01_06_425581 130 18 that that DT 10_1101-2021_01_06_425581 130 19 most most JJS 10_1101-2021_01_06_425581 130 20 sampling sampling NN 10_1101-2021_01_06_425581 130 21 time time NN 10_1101-2021_01_06_425581 130 22 points point NNS 10_1101-2021_01_06_425581 130 23 only only RB 10_1101-2021_01_06_425581 130 24 feature feature VBP 10_1101-2021_01_06_425581 130 25 a a DT 10_1101-2021_01_06_425581 130 26 few few JJ 10_1101-2021_01_06_425581 130 27 cell cell NN 10_1101-2021_01_06_425581 130 28 births birth NNS 10_1101-2021_01_06_425581 130 29 , , , 10_1101-2021_01_06_425581 130 30 while while IN 10_1101-2021_01_06_425581 130 31 a a DT 10_1101-2021_01_06_425581 130 32 small small JJ 10_1101-2021_01_06_425581 130 33 number number NN 10_1101-2021_01_06_425581 130 34 of of IN 10_1101-2021_01_06_425581 130 35 sampling sample VBG 10_1101-2021_01_06_425581 130 36 time time NN 10_1101-2021_01_06_425581 130 37 points point NNS 10_1101-2021_01_06_425581 130 38 represents represent VBZ 10_1101-2021_01_06_425581 130 39 a a DT 10_1101-2021_01_06_425581 130 40 large large JJ 10_1101-2021_01_06_425581 130 41 number number NN 10_1101-2021_01_06_425581 130 42 of of IN 10_1101-2021_01_06_425581 130 43 cells cell NNS 10_1101-2021_01_06_425581 130 44 born bear VBN 10_1101-2021_01_06_425581 130 45 . . . 10_1101-2021_01_06_425581 131 1 For for IN 10_1101-2021_01_06_425581 131 2 example example NN 10_1101-2021_01_06_425581 131 3 , , , 10_1101-2021_01_06_425581 131 4 a a DT 10_1101-2021_01_06_425581 131 5 large large JJ 10_1101-2021_01_06_425581 131 6 majority majority NN 10_1101-2021_01_06_425581 131 7 of of IN 10_1101-2021_01_06_425581 131 8 sampling sample VBG 10_1101-2021_01_06_425581 131 9 time time NN 10_1101-2021_01_06_425581 131 10 points point NNS 10_1101-2021_01_06_425581 131 11 feature feature VBP 10_1101-2021_01_06_425581 131 12 fewer few JJR 10_1101-2021_01_06_425581 131 13 than than IN 10_1101-2021_01_06_425581 131 14 25 25 CD 10_1101-2021_01_06_425581 131 15 new new JJ 10_1101-2021_01_06_425581 131 16 cells cell NNS 10_1101-2021_01_06_425581 131 17 per per IN 10_1101-2021_01_06_425581 131 18 time time NN 10_1101-2021_01_06_425581 131 19 point point NN 10_1101-2021_01_06_425581 131 20 . . . 10_1101-2021_01_06_425581 132 1 By by IN 10_1101-2021_01_06_425581 132 2 contrast contrast NN 10_1101-2021_01_06_425581 132 3 , , , 10_1101-2021_01_06_425581 132 4 there there EX 10_1101-2021_01_06_425581 132 5 are be VBP 10_1101-2021_01_06_425581 132 6 also also RB 10_1101-2021_01_06_425581 132 7 single single JJ 10_1101-2021_01_06_425581 132 8 sampling sampling NN 10_1101-2021_01_06_425581 132 9 points point NNS 10_1101-2021_01_06_425581 132 10 where where WRB 10_1101-2021_01_06_425581 132 11 over over IN 10_1101-2021_01_06_425581 132 12 70 70 CD 10_1101-2021_01_06_425581 132 13 cells cell NNS 10_1101-2021_01_06_425581 132 14 are be VBP 10_1101-2021_01_06_425581 132 15 born bear VBN 10_1101-2021_01_06_425581 132 16 at at IN 10_1101-2021_01_06_425581 132 17 a a DT 10_1101-2021_01_06_425581 132 18 single single JJ 10_1101-2021_01_06_425581 132 19 time time NN 10_1101-2021_01_06_425581 132 20 . . . 10_1101-2021_01_06_425581 133 1 In in IN 10_1101-2021_01_06_425581 133 2 terms term NNS 10_1101-2021_01_06_425581 133 3 of of IN 10_1101-2021_01_06_425581 133 4 the the DT 10_1101-2021_01_06_425581 133 5 4 4 CD 10_1101-2021_01_06_425581 133 6 .CC .CC NFP 10_1101-2021_01_06_425581 133 7 - - HYPH 10_1101-2021_01_06_425581 133 8 BY BY NNP 10_1101-2021_01_06_425581 133 9 - - HYPH 10_1101-2021_01_06_425581 133 10 NC NC NNP 10_1101-2021_01_06_425581 133 11 4.0 4.0 CD 10_1101-2021_01_06_425581 133 12 International international JJ 10_1101-2021_01_06_425581 133 13 licensemade licensemade NN 10_1101-2021_01_06_425581 133 14 available available JJ 10_1101-2021_01_06_425581 133 15 under under IN 10_1101-2021_01_06_425581 133 16 a a DT 10_1101-2021_01_06_425581 133 17 ( ( -LRB- 10_1101-2021_01_06_425581 133 18 which which WDT 10_1101-2021_01_06_425581 133 19 was be VBD 10_1101-2021_01_06_425581 133 20 not not RB 10_1101-2021_01_06_425581 133 21 certified certify VBN 10_1101-2021_01_06_425581 133 22 by by IN 10_1101-2021_01_06_425581 133 23 peer peer NN 10_1101-2021_01_06_425581 133 24 review review NN 10_1101-2021_01_06_425581 133 25 ) ) -RRB- 10_1101-2021_01_06_425581 133 26 is be VBZ 10_1101-2021_01_06_425581 133 27 the the DT 10_1101-2021_01_06_425581 133 28 author author NN 10_1101-2021_01_06_425581 133 29 / / SYM 10_1101-2021_01_06_425581 133 30 funder funder NN 10_1101-2021_01_06_425581 133 31 , , , 10_1101-2021_01_06_425581 133 32 who who WP 10_1101-2021_01_06_425581 133 33 has have VBZ 10_1101-2021_01_06_425581 133 34 granted grant VBN 10_1101-2021_01_06_425581 133 35 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 133 36 a a DT 10_1101-2021_01_06_425581 133 37 license license NN 10_1101-2021_01_06_425581 133 38 to to TO 10_1101-2021_01_06_425581 133 39 display display VB 10_1101-2021_01_06_425581 133 40 the the DT 10_1101-2021_01_06_425581 133 41 preprint preprint NN 10_1101-2021_01_06_425581 133 42 in in IN 10_1101-2021_01_06_425581 133 43 perpetuity perpetuity NN 10_1101-2021_01_06_425581 133 44 . . . 10_1101-2021_01_06_425581 134 1 It -PRON- PRP 10_1101-2021_01_06_425581 134 2 is be VBZ 10_1101-2021_01_06_425581 134 3 The the DT 10_1101-2021_01_06_425581 134 4 copyright copyright NN 10_1101-2021_01_06_425581 134 5 holder holder NN 10_1101-2021_01_06_425581 134 6 for for IN 10_1101-2021_01_06_425581 134 7 this this DT 10_1101-2021_01_06_425581 134 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 134 9 version version NN 10_1101-2021_01_06_425581 134 10 posted post VBD 10_1101-2021_01_06_425581 134 11 January January NNP 10_1101-2021_01_06_425581 134 12 8 8 CD 10_1101-2021_01_06_425581 134 13 , , , 10_1101-2021_01_06_425581 134 14 2021 2021 CD 10_1101-2021_01_06_425581 134 15 . . . 10_1101-2021_01_06_425581 134 16 ; ; : 10_1101-2021_01_06_425581 134 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 134 18 : : : 10_1101-2021_01_06_425581 134 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 134 20 preprint preprint NN 10_1101-2021_01_06_425581 134 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 NNP 10_1101-2021_01_06_425581 134 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 134 23 power power NN 10_1101-2021_01_06_425581 134 24 spectrum spectrum NNP 10_1101-2021_01_06_425581 134 25 shown show VBN 10_1101-2021_01_06_425581 134 26 in in IN 10_1101-2021_01_06_425581 134 27 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 134 28 Figure Figure NNP 10_1101-2021_01_06_425581 134 29 4 4 CD 10_1101-2021_01_06_425581 134 30 , , , 10_1101-2021_01_06_425581 134 31 there there EX 10_1101-2021_01_06_425581 134 32 is be VBZ 10_1101-2021_01_06_425581 134 33 a a DT 10_1101-2021_01_06_425581 134 34 very very RB 10_1101-2021_01_06_425581 134 35 high high JJ 10_1101-2021_01_06_425581 134 36 amplitude amplitude NN 10_1101-2021_01_06_425581 134 37 at at IN 10_1101-2021_01_06_425581 134 38 very very RB 10_1101-2021_01_06_425581 134 39 low low JJ 10_1101-2021_01_06_425581 134 40 frequencies frequency NNS 10_1101-2021_01_06_425581 134 41 , , , 10_1101-2021_01_06_425581 134 42 perhaps perhaps RB 10_1101-2021_01_06_425581 134 43 related relate VBN 10_1101-2021_01_06_425581 134 44 to to IN 10_1101-2021_01_06_425581 134 45 the the DT 10_1101-2021_01_06_425581 134 46 significant significant JJ 10_1101-2021_01_06_425581 134 47 noise noise NN 10_1101-2021_01_06_425581 134 48 and and CC 10_1101-2021_01_06_425581 134 49 aperiodicity aperiodicity NN 10_1101-2021_01_06_425581 134 50 in in IN 10_1101-2021_01_06_425581 134 51 the the DT 10_1101-2021_01_06_425581 134 52 later later JJ 10_1101-2021_01_06_425581 134 53 part part NN 10_1101-2021_01_06_425581 134 54 of of IN 10_1101-2021_01_06_425581 134 55 the the DT 10_1101-2021_01_06_425581 134 56 time time NN 10_1101-2021_01_06_425581 134 57 - - HYPH 10_1101-2021_01_06_425581 134 58 series series NN 10_1101-2021_01_06_425581 134 59 shown show VBN 10_1101-2021_01_06_425581 134 60 in in IN 10_1101-2021_01_06_425581 134 61 Figure Figure NNP 10_1101-2021_01_06_425581 134 62 2 2 CD 10_1101-2021_01_06_425581 134 63 . . . 10_1101-2021_01_06_425581 135 1 Figure figure NN 10_1101-2021_01_06_425581 135 2 2 2 CD 10_1101-2021_01_06_425581 135 3 . . . 10_1101-2021_01_06_425581 136 1 The the DT 10_1101-2021_01_06_425581 136 2 interval interval NN 10_1101-2021_01_06_425581 136 3 between between IN 10_1101-2021_01_06_425581 136 4 cell cell NN 10_1101-2021_01_06_425581 136 5 division division NN 10_1101-2021_01_06_425581 136 6 events event NNS 10_1101-2021_01_06_425581 136 7 across across IN 10_1101-2021_01_06_425581 136 8 embryonic embryonic JJ 10_1101-2021_01_06_425581 136 9 development development NN 10_1101-2021_01_06_425581 136 10 in in IN 10_1101-2021_01_06_425581 136 11 C. C. NNP 10_1101-2021_01_06_425581 136 12 elegans elegan NNS 10_1101-2021_01_06_425581 136 13 ​. ​. VBP 10_1101-2021_01_06_425581 137 1 Considering consider VBG 10_1101-2021_01_06_425581 137 2 the the DT 10_1101-2021_01_06_425581 137 3 cell cell NN 10_1101-2021_01_06_425581 137 4 divisions division NNS 10_1101-2021_01_06_425581 137 5 for for IN 10_1101-2021_01_06_425581 137 6 the the DT 10_1101-2021_01_06_425581 137 7 first first JJ 10_1101-2021_01_06_425581 137 8 period period NN 10_1101-2021_01_06_425581 137 9 of of IN 10_1101-2021_01_06_425581 137 10 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 137 11 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 137 12 , , , 10_1101-2021_01_06_425581 137 13 we -PRON- PRP 10_1101-2021_01_06_425581 137 14 conduct conduct VBP 10_1101-2021_01_06_425581 137 15 an an DT 10_1101-2021_01_06_425581 137 16 interval interval JJ 10_1101-2021_01_06_425581 137 17 analysis analysis NN 10_1101-2021_01_06_425581 137 18 for for IN 10_1101-2021_01_06_425581 137 19 each each DT 10_1101-2021_01_06_425581 137 20 oscillation oscillation NN 10_1101-2021_01_06_425581 137 21 of of IN 10_1101-2021_01_06_425581 137 22 the the DT 10_1101-2021_01_06_425581 137 23 data datum NNS 10_1101-2021_01_06_425581 137 24 shown show VBN 10_1101-2021_01_06_425581 137 25 in in IN 10_1101-2021_01_06_425581 137 26 Figure Figure NNP 10_1101-2021_01_06_425581 137 27 5 5 CD 10_1101-2021_01_06_425581 137 28 for for IN 10_1101-2021_01_06_425581 137 29 ​C. ​c. ADD 10_1101-2021_01_06_425581 138 1 elegans elegans NNP 10_1101-2021_01_06_425581 138 2 ( ( -LRB- 10_1101-2021_01_06_425581 138 3 top top NNP 10_1101-2021_01_06_425581 138 4 ) ) -RRB- 10_1101-2021_01_06_425581 138 5 and and CC 10_1101-2021_01_06_425581 138 6 ​D. ​D. . 10_1101-2021_01_06_425581 139 1 rerio rerio NNP 10_1101-2021_01_06_425581 139 2 ( ( -LRB- 10_1101-2021_01_06_425581 139 3 bottom bottom NN 10_1101-2021_01_06_425581 139 4 ) ) -RRB- 10_1101-2021_01_06_425581 139 5 . . . 10_1101-2021_01_06_425581 140 1 These these DT 10_1101-2021_01_06_425581 140 2 are be VBP 10_1101-2021_01_06_425581 140 3 measured measure VBN 10_1101-2021_01_06_425581 140 4 from from IN 10_1101-2021_01_06_425581 140 5 peak peak NN 10_1101-2021_01_06_425581 140 6 to to IN 10_1101-2021_01_06_425581 140 7 peak peak NN 10_1101-2021_01_06_425581 140 8 as as IN 10_1101-2021_01_06_425581 140 9 described describe VBN 10_1101-2021_01_06_425581 140 10 in in IN 10_1101-2021_01_06_425581 140 11 the the DT 10_1101-2021_01_06_425581 140 12 Methods Methods NNPS 10_1101-2021_01_06_425581 140 13 . . . 10_1101-2021_01_06_425581 141 1 For for IN 10_1101-2021_01_06_425581 141 2 the the DT 10_1101-2021_01_06_425581 141 3 analysis analysis NN 10_1101-2021_01_06_425581 141 4 of of IN 10_1101-2021_01_06_425581 141 5 ​C. ​C. NNP 10_1101-2021_01_06_425581 142 1 elegans elegans NNPS 10_1101-2021_01_06_425581 142 2 data datum NNS 10_1101-2021_01_06_425581 142 3 ( ( -LRB- 10_1101-2021_01_06_425581 142 4 Figure Figure NNP 10_1101-2021_01_06_425581 142 5 5 5 CD 10_1101-2021_01_06_425581 142 6 , , , 10_1101-2021_01_06_425581 142 7 top top NN 10_1101-2021_01_06_425581 142 8 ) ) -RRB- 10_1101-2021_01_06_425581 142 9 , , , 10_1101-2021_01_06_425581 142 10 our -PRON- PRP$ 10_1101-2021_01_06_425581 142 11 analysis analysis NN 10_1101-2021_01_06_425581 142 12 yields yield VBZ 10_1101-2021_01_06_425581 142 13 a a DT 10_1101-2021_01_06_425581 142 14 roughly roughly RB 10_1101-2021_01_06_425581 142 15 unimodal unimodal JJ 10_1101-2021_01_06_425581 142 16 distribution distribution NN 10_1101-2021_01_06_425581 142 17 , , , 10_1101-2021_01_06_425581 142 18 with with IN 10_1101-2021_01_06_425581 142 19 a a DT 10_1101-2021_01_06_425581 142 20 mean mean JJ 10_1101-2021_01_06_425581 142 21 peak peak NN 10_1101-2021_01_06_425581 142 22 interval interval NN 10_1101-2021_01_06_425581 142 23 of of IN 10_1101-2021_01_06_425581 142 24 3 3 CD 10_1101-2021_01_06_425581 142 25 - - SYM 10_1101-2021_01_06_425581 142 26 5 5 CD 10_1101-2021_01_06_425581 142 27 minutes minute NNS 10_1101-2021_01_06_425581 142 28 . . . 10_1101-2021_01_06_425581 143 1 In in IN 10_1101-2021_01_06_425581 143 2 pre pre JJ 10_1101-2021_01_06_425581 143 3 - - NN 10_1101-2021_01_06_425581 143 4 hatch hatch JJ 10_1101-2021_01_06_425581 143 5 ​C. ​c. NN 10_1101-2021_01_06_425581 144 1 elegans elegans NNPS 10_1101-2021_01_06_425581 144 2 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 144 3 , , , 10_1101-2021_01_06_425581 144 4 there there EX 10_1101-2021_01_06_425581 144 5 are be VBP 10_1101-2021_01_06_425581 144 6 many many JJ 10_1101-2021_01_06_425581 144 7 quick quick JJ 10_1101-2021_01_06_425581 144 8 bursts burst NNS 10_1101-2021_01_06_425581 144 9 of of IN 10_1101-2021_01_06_425581 144 10 cell cell NN 10_1101-2021_01_06_425581 144 11 division division NN 10_1101-2021_01_06_425581 144 12 as as IN 10_1101-2021_01_06_425581 144 13 confirmed confirm VBN 10_1101-2021_01_06_425581 144 14 in in IN 10_1101-2021_01_06_425581 144 15 Figure Figure NNP 10_1101-2021_01_06_425581 144 16 1 1 CD 10_1101-2021_01_06_425581 144 17 ( ( -LRB- 10_1101-2021_01_06_425581 144 18 top top NN 10_1101-2021_01_06_425581 144 19 ) ) -RRB- 10_1101-2021_01_06_425581 144 20 . . . 10_1101-2021_01_06_425581 145 1 This this DT 10_1101-2021_01_06_425581 145 2 results result VBZ 10_1101-2021_01_06_425581 145 3 in in IN 10_1101-2021_01_06_425581 145 4 bursty bursty JJ 10_1101-2021_01_06_425581 145 5 behavior behavior NN 10_1101-2021_01_06_425581 145 6 that that WDT 10_1101-2021_01_06_425581 145 7 is be VBZ 10_1101-2021_01_06_425581 145 8 regular regular JJ 10_1101-2021_01_06_425581 145 9 and and CC 10_1101-2021_01_06_425581 145 10 perhaps perhaps RB 10_1101-2021_01_06_425581 145 11 even even RB 10_1101-2021_01_06_425581 145 12 periodic periodic JJ 10_1101-2021_01_06_425581 145 13 . . . 10_1101-2021_01_06_425581 146 1 By by IN 10_1101-2021_01_06_425581 146 2 contrast contrast NN 10_1101-2021_01_06_425581 146 3 . . . 10_1101-2021_01_06_425581 146 4 , , , 10_1101-2021_01_06_425581 146 5 an an DT 10_1101-2021_01_06_425581 146 6 analysis analysis NN 10_1101-2021_01_06_425581 146 7 of of IN 10_1101-2021_01_06_425581 146 8 our -PRON- PRP$ 10_1101-2021_01_06_425581 146 9 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 146 10 data data NN 10_1101-2021_01_06_425581 146 11 yields yield NNS 10_1101-2021_01_06_425581 146 12 three three CD 10_1101-2021_01_06_425581 146 13 interval interval JJ 10_1101-2021_01_06_425581 146 14 groups group NNS 10_1101-2021_01_06_425581 146 15 ( ( -LRB- 10_1101-2021_01_06_425581 146 16 Figure figure NN 10_1101-2021_01_06_425581 146 17 5 5 CD 10_1101-2021_01_06_425581 146 18 , , , 10_1101-2021_01_06_425581 146 19 bottom bottom NN 10_1101-2021_01_06_425581 146 20 ) ) -RRB- 10_1101-2021_01_06_425581 146 21 : : : 10_1101-2021_01_06_425581 146 22 the the DT 10_1101-2021_01_06_425581 146 23 greatest great JJS 10_1101-2021_01_06_425581 146 24 number number NN 10_1101-2021_01_06_425581 146 25 of of IN 10_1101-2021_01_06_425581 146 26 oscillations oscillation NNS 10_1101-2021_01_06_425581 146 27 occurs occur VBZ 10_1101-2021_01_06_425581 146 28 at at IN 10_1101-2021_01_06_425581 146 29 a a DT 10_1101-2021_01_06_425581 146 30 period period NN 10_1101-2021_01_06_425581 146 31 of of IN 10_1101-2021_01_06_425581 146 32 2 2 CD 10_1101-2021_01_06_425581 146 33 - - SYM 10_1101-2021_01_06_425581 146 34 5 5 CD 10_1101-2021_01_06_425581 146 35 minutes minute NNS 10_1101-2021_01_06_425581 146 36 , , , 10_1101-2021_01_06_425581 146 37 while while IN 10_1101-2021_01_06_425581 146 38 a a DT 10_1101-2021_01_06_425581 146 39 smaller small JJR 10_1101-2021_01_06_425581 146 40 number number NN 10_1101-2021_01_06_425581 146 41 of of IN 10_1101-2021_01_06_425581 146 42 oscillations oscillation NNS 10_1101-2021_01_06_425581 146 43 occur occur VBP 10_1101-2021_01_06_425581 146 44 with with IN 10_1101-2021_01_06_425581 146 45 periods period NNS 10_1101-2021_01_06_425581 146 46 from from IN 10_1101-2021_01_06_425581 146 47 16 16 CD 10_1101-2021_01_06_425581 146 48 - - SYM 10_1101-2021_01_06_425581 146 49 19 19 CD 10_1101-2021_01_06_425581 146 50 . . . 10_1101-2021_01_06_425581 147 1 There there EX 10_1101-2021_01_06_425581 147 2 is be VBZ 10_1101-2021_01_06_425581 147 3 also also RB 10_1101-2021_01_06_425581 147 4 a a DT 10_1101-2021_01_06_425581 147 5 longer long JJR 10_1101-2021_01_06_425581 147 6 22-minute 22-minute CD 10_1101-2021_01_06_425581 147 7 interval interval NN 10_1101-2021_01_06_425581 147 8 between between IN 10_1101-2021_01_06_425581 147 9 oscillations oscillation NNS 10_1101-2021_01_06_425581 147 10 . . . 10_1101-2021_01_06_425581 148 1 This this DT 10_1101-2021_01_06_425581 148 2 is be VBZ 10_1101-2021_01_06_425581 148 3 consistent consistent JJ 10_1101-2021_01_06_425581 148 4 with with IN 10_1101-2021_01_06_425581 148 5 the the DT 10_1101-2021_01_06_425581 148 6 shift shift NN 10_1101-2021_01_06_425581 148 7 from from IN 10_1101-2021_01_06_425581 148 8 periodic periodic JJ 10_1101-2021_01_06_425581 148 9 bursts burst NNS 10_1101-2021_01_06_425581 148 10 to to IN 10_1101-2021_01_06_425581 148 11 aperiodic aperiodic JJ 10_1101-2021_01_06_425581 148 12 but but CC 10_1101-2021_01_06_425581 148 13 still still RB 10_1101-2021_01_06_425581 148 14 bursty bursty JJ 10_1101-2021_01_06_425581 148 15 behavior behavior NN 10_1101-2021_01_06_425581 148 16 later later RB 10_1101-2021_01_06_425581 148 17 in in IN 10_1101-2021_01_06_425581 148 18 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 148 19 development development NN 10_1101-2021_01_06_425581 148 20 shown show VBN 10_1101-2021_01_06_425581 148 21 in in IN 10_1101-2021_01_06_425581 148 22 Figure Figure NNP 10_1101-2021_01_06_425581 148 23 3 3 CD 10_1101-2021_01_06_425581 148 24 . . . 10_1101-2021_01_06_425581 149 1 This this DT 10_1101-2021_01_06_425581 149 2 multimodal multimodal NN 10_1101-2021_01_06_425581 149 3 distribution distribution NN 10_1101-2021_01_06_425581 149 4 of of IN 10_1101-2021_01_06_425581 149 5 peaks peak NNS 10_1101-2021_01_06_425581 149 6 points point NNS 10_1101-2021_01_06_425581 149 7 to to IN 10_1101-2021_01_06_425581 149 8 a a DT 10_1101-2021_01_06_425581 149 9 more more RBR 10_1101-2021_01_06_425581 149 10 complex complex JJ 10_1101-2021_01_06_425581 149 11 process process NN 10_1101-2021_01_06_425581 149 12 at at IN 10_1101-2021_01_06_425581 149 13 play play NN 10_1101-2021_01_06_425581 149 14 , , , 10_1101-2021_01_06_425581 149 15 something something NN 10_1101-2021_01_06_425581 149 16 that that WDT 10_1101-2021_01_06_425581 149 17 might may MD 10_1101-2021_01_06_425581 149 18 be be VB 10_1101-2021_01_06_425581 149 19 better well RBR 10_1101-2021_01_06_425581 149 20 understood understand VBN 10_1101-2021_01_06_425581 149 21 by by IN 10_1101-2021_01_06_425581 149 22 investigating investigate VBG 10_1101-2021_01_06_425581 149 23 morphogenesis morphogenesis NN 10_1101-2021_01_06_425581 149 24 as as IN 10_1101-2021_01_06_425581 149 25 a a DT 10_1101-2021_01_06_425581 149 26 spatial spatial JJ 10_1101-2021_01_06_425581 149 27 process process NN 10_1101-2021_01_06_425581 149 28 . . . 10_1101-2021_01_06_425581 150 1 Embryo Embryo NNP 10_1101-2021_01_06_425581 150 2 Networks Networks NNPS 10_1101-2021_01_06_425581 150 3 : : : 10_1101-2021_01_06_425581 150 4 an an DT 10_1101-2021_01_06_425581 150 5 example example NN 10_1101-2021_01_06_425581 150 6 from from IN 10_1101-2021_01_06_425581 150 7 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 150 8 Another another DT 10_1101-2021_01_06_425581 150 9 way way NN 10_1101-2021_01_06_425581 150 10 to to TO 10_1101-2021_01_06_425581 150 11 identify identify VB 10_1101-2021_01_06_425581 150 12 the the DT 10_1101-2021_01_06_425581 150 13 consequences consequence NNS 10_1101-2021_01_06_425581 150 14 of of IN 10_1101-2021_01_06_425581 150 15 bursts burst NNS 10_1101-2021_01_06_425581 150 16 in in IN 10_1101-2021_01_06_425581 150 17 cell cell NN 10_1101-2021_01_06_425581 150 18 division division NN 10_1101-2021_01_06_425581 150 19 timing timing NN 10_1101-2021_01_06_425581 150 20 and and CC 10_1101-2021_01_06_425581 150 21 other other JJ 10_1101-2021_01_06_425581 150 22 non non JJ 10_1101-2021_01_06_425581 150 23 - - JJ 10_1101-2021_01_06_425581 150 24 uniform uniform JJ 10_1101-2021_01_06_425581 150 25 temporal temporal JJ 10_1101-2021_01_06_425581 150 26 phenomena phenomena NN 10_1101-2021_01_06_425581 150 27 is be VBZ 10_1101-2021_01_06_425581 150 28 to to TO 10_1101-2021_01_06_425581 150 29 utilize utilize VB 10_1101-2021_01_06_425581 150 30 embryo embryo NN 10_1101-2021_01_06_425581 150 31 networks network NNS 10_1101-2021_01_06_425581 150 32 . . . 10_1101-2021_01_06_425581 151 1 An an DT 10_1101-2021_01_06_425581 151 2 embryo embryo NN 10_1101-2021_01_06_425581 151 3 network network NN 10_1101-2021_01_06_425581 151 4 was be VBD 10_1101-2021_01_06_425581 151 5 constructed construct VBN 10_1101-2021_01_06_425581 151 6 ( ( -LRB- 10_1101-2021_01_06_425581 151 7 Figure Figure NNP 10_1101-2021_01_06_425581 151 8 6 6 CD 10_1101-2021_01_06_425581 151 9 , , , 10_1101-2021_01_06_425581 151 10 Top Top NNP 10_1101-2021_01_06_425581 151 11 ) ) -RRB- 10_1101-2021_01_06_425581 151 12 for for IN 10_1101-2021_01_06_425581 151 13 cells cell NNS 10_1101-2021_01_06_425581 151 14 born bear VBN 10_1101-2021_01_06_425581 151 15 during during IN 10_1101-2021_01_06_425581 151 16 our -PRON- PRP$ 10_1101-2021_01_06_425581 151 17 sampling sampling NN 10_1101-2021_01_06_425581 151 18 time time NN 10_1101-2021_01_06_425581 151 19 5 5 CD 10_1101-2021_01_06_425581 151 20 .CC .CC : 10_1101-2021_01_06_425581 151 21 - - HYPH 10_1101-2021_01_06_425581 151 22 BY BY NNP 10_1101-2021_01_06_425581 151 23 - - HYPH 10_1101-2021_01_06_425581 151 24 NC NC NNP 10_1101-2021_01_06_425581 151 25 4.0 4.0 CD 10_1101-2021_01_06_425581 151 26 International international JJ 10_1101-2021_01_06_425581 151 27 licensemade licensemade NN 10_1101-2021_01_06_425581 151 28 available available JJ 10_1101-2021_01_06_425581 151 29 under under IN 10_1101-2021_01_06_425581 151 30 a a DT 10_1101-2021_01_06_425581 151 31 ( ( -LRB- 10_1101-2021_01_06_425581 151 32 which which WDT 10_1101-2021_01_06_425581 151 33 was be VBD 10_1101-2021_01_06_425581 151 34 not not RB 10_1101-2021_01_06_425581 151 35 certified certify VBN 10_1101-2021_01_06_425581 151 36 by by IN 10_1101-2021_01_06_425581 151 37 peer peer NN 10_1101-2021_01_06_425581 151 38 review review NN 10_1101-2021_01_06_425581 151 39 ) ) -RRB- 10_1101-2021_01_06_425581 151 40 is be VBZ 10_1101-2021_01_06_425581 151 41 the the DT 10_1101-2021_01_06_425581 151 42 author author NN 10_1101-2021_01_06_425581 151 43 / / SYM 10_1101-2021_01_06_425581 151 44 funder funder NN 10_1101-2021_01_06_425581 151 45 , , , 10_1101-2021_01_06_425581 151 46 who who WP 10_1101-2021_01_06_425581 151 47 has have VBZ 10_1101-2021_01_06_425581 151 48 granted grant VBN 10_1101-2021_01_06_425581 151 49 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 151 50 a a DT 10_1101-2021_01_06_425581 151 51 license license NN 10_1101-2021_01_06_425581 151 52 to to TO 10_1101-2021_01_06_425581 151 53 display display VB 10_1101-2021_01_06_425581 151 54 the the DT 10_1101-2021_01_06_425581 151 55 preprint preprint NN 10_1101-2021_01_06_425581 151 56 in in IN 10_1101-2021_01_06_425581 151 57 perpetuity perpetuity NN 10_1101-2021_01_06_425581 151 58 . . . 10_1101-2021_01_06_425581 152 1 It -PRON- PRP 10_1101-2021_01_06_425581 152 2 is be VBZ 10_1101-2021_01_06_425581 152 3 The the DT 10_1101-2021_01_06_425581 152 4 copyright copyright NN 10_1101-2021_01_06_425581 152 5 holder holder NN 10_1101-2021_01_06_425581 152 6 for for IN 10_1101-2021_01_06_425581 152 7 this this DT 10_1101-2021_01_06_425581 152 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 152 9 version version NN 10_1101-2021_01_06_425581 152 10 posted post VBD 10_1101-2021_01_06_425581 152 11 January January NNP 10_1101-2021_01_06_425581 152 12 8 8 CD 10_1101-2021_01_06_425581 152 13 , , , 10_1101-2021_01_06_425581 152 14 2021 2021 CD 10_1101-2021_01_06_425581 152 15 . . . 10_1101-2021_01_06_425581 152 16 ; ; : 10_1101-2021_01_06_425581 152 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 152 18 : : : 10_1101-2021_01_06_425581 152 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 152 20 preprint preprint NN 10_1101-2021_01_06_425581 152 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 152 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 152 23 points point NNS 10_1101-2021_01_06_425581 152 24 of of IN 10_1101-2021_01_06_425581 152 25 ​D. ​D. NNP 10_1101-2021_01_06_425581 153 1 rerio rerio NNP 10_1101-2021_01_06_425581 153 2 ​embryogenesis ​embryogenesis NNP 10_1101-2021_01_06_425581 153 3 . . . 10_1101-2021_01_06_425581 154 1 The the DT 10_1101-2021_01_06_425581 154 2 resulting result VBG 10_1101-2021_01_06_425581 154 3 circular circular JJ 10_1101-2021_01_06_425581 154 4 graph graph NN 10_1101-2021_01_06_425581 154 5 demonstrates demonstrate VBZ 10_1101-2021_01_06_425581 154 6 a a DT 10_1101-2021_01_06_425581 154 7 high high JJ 10_1101-2021_01_06_425581 154 8 degree degree NN 10_1101-2021_01_06_425581 154 9 of of IN 10_1101-2021_01_06_425581 154 10 modularity modularity NN 10_1101-2021_01_06_425581 154 11 , , , 10_1101-2021_01_06_425581 154 12 but but CC 10_1101-2021_01_06_425581 154 13 only only RB 10_1101-2021_01_06_425581 154 14 across across IN 10_1101-2021_01_06_425581 154 15 part part NN 10_1101-2021_01_06_425581 154 16 of of IN 10_1101-2021_01_06_425581 154 17 the the DT 10_1101-2021_01_06_425581 154 18 graph graph NN 10_1101-2021_01_06_425581 154 19 . . . 10_1101-2021_01_06_425581 155 1 Figure figure NN 10_1101-2021_01_06_425581 155 2 3 3 CD 10_1101-2021_01_06_425581 155 3 . . . 10_1101-2021_01_06_425581 156 1 Cell cell NN 10_1101-2021_01_06_425581 156 2 births birth NNS 10_1101-2021_01_06_425581 156 3 in in IN 10_1101-2021_01_06_425581 156 4 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 156 5 embryos embryo NNS 10_1101-2021_01_06_425581 156 6 during during IN 10_1101-2021_01_06_425581 156 7 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 156 8 up up RB 10_1101-2021_01_06_425581 156 9 to to IN 10_1101-2021_01_06_425581 156 10 the the DT 10_1101-2021_01_06_425581 156 11 Gastrula Gastrula NNP 10_1101-2021_01_06_425581 156 12 stage stage NN 10_1101-2021_01_06_425581 156 13 . . . 10_1101-2021_01_06_425581 157 1 Instead instead RB 10_1101-2021_01_06_425581 157 2 of of IN 10_1101-2021_01_06_425581 157 3 developmental developmental JJ 10_1101-2021_01_06_425581 157 4 time time NN 10_1101-2021_01_06_425581 157 5 , , , 10_1101-2021_01_06_425581 157 6 relative relative JJ 10_1101-2021_01_06_425581 157 7 developmental developmental JJ 10_1101-2021_01_06_425581 157 8 progress progress NN 10_1101-2021_01_06_425581 157 9 is be VBZ 10_1101-2021_01_06_425581 157 10 plotted plot VBN 10_1101-2021_01_06_425581 157 11 as as IN 10_1101-2021_01_06_425581 157 12 all all DT 10_1101-2021_01_06_425581 157 13 cells cell NNS 10_1101-2021_01_06_425581 157 14 observed observe VBN 10_1101-2021_01_06_425581 157 15 in in IN 10_1101-2021_01_06_425581 157 16 the the DT 10_1101-2021_01_06_425581 157 17 embryo embryo NN 10_1101-2021_01_06_425581 157 18 at at IN 10_1101-2021_01_06_425581 157 19 each each DT 10_1101-2021_01_06_425581 157 20 sampling sampling NN 10_1101-2021_01_06_425581 157 21 time time NN 10_1101-2021_01_06_425581 157 22 point point NN 10_1101-2021_01_06_425581 157 23 . . . 10_1101-2021_01_06_425581 158 1 For for IN 10_1101-2021_01_06_425581 158 2 Figure figure NN 10_1101-2021_01_06_425581 158 3 3 3 CD 10_1101-2021_01_06_425581 158 4 , , , 10_1101-2021_01_06_425581 158 5 bottom bottom NN 10_1101-2021_01_06_425581 158 6 : : : 10_1101-2021_01_06_425581 158 7 Periodic periodic JJ 10_1101-2021_01_06_425581 158 8 region region NN 10_1101-2021_01_06_425581 158 9 ( ( -LRB- 10_1101-2021_01_06_425581 158 10 red red NNP 10_1101-2021_01_06_425581 158 11 ) ) -RRB- 10_1101-2021_01_06_425581 158 12 , , , 10_1101-2021_01_06_425581 158 13 Aperiodic aperiodic JJ 10_1101-2021_01_06_425581 158 14 region region NN 10_1101-2021_01_06_425581 158 15 ( ( -LRB- 10_1101-2021_01_06_425581 158 16 unshaded unshaded JJ 10_1101-2021_01_06_425581 158 17 ) ) -RRB- 10_1101-2021_01_06_425581 158 18 . . . 10_1101-2021_01_06_425581 159 1 A a DT 10_1101-2021_01_06_425581 159 2 three three CD 10_1101-2021_01_06_425581 159 3 - - HYPH 10_1101-2021_01_06_425581 159 4 dimensional dimensional JJ 10_1101-2021_01_06_425581 159 5 plot plot NN 10_1101-2021_01_06_425581 159 6 ( ( -LRB- 10_1101-2021_01_06_425581 159 7 Figure Figure NNP 10_1101-2021_01_06_425581 159 8 6 6 CD 10_1101-2021_01_06_425581 159 9 , , , 10_1101-2021_01_06_425581 159 10 Bottom Bottom NNP 10_1101-2021_01_06_425581 159 11 ) ) -RRB- 10_1101-2021_01_06_425581 159 12 demonstrating demonstrate VBG 10_1101-2021_01_06_425581 159 13 the the DT 10_1101-2021_01_06_425581 159 14 position position NN 10_1101-2021_01_06_425581 159 15 of of IN 10_1101-2021_01_06_425581 159 16 each each DT 10_1101-2021_01_06_425581 159 17 cell cell NN 10_1101-2021_01_06_425581 159 18 born bear VBN 10_1101-2021_01_06_425581 159 19 during during IN 10_1101-2021_01_06_425581 159 20 these these DT 10_1101-2021_01_06_425581 159 21 stages stage NNS 10_1101-2021_01_06_425581 159 22 of of IN 10_1101-2021_01_06_425581 159 23 development development NN 10_1101-2021_01_06_425581 159 24 shows show VBZ 10_1101-2021_01_06_425581 159 25 that that IN 10_1101-2021_01_06_425581 159 26 the the DT 10_1101-2021_01_06_425581 159 27 highest high JJS 10_1101-2021_01_06_425581 159 28 degrees degree NNS 10_1101-2021_01_06_425581 159 29 of of IN 10_1101-2021_01_06_425581 159 30 connectivity connectivity NN 10_1101-2021_01_06_425581 159 31 are be VBP 10_1101-2021_01_06_425581 159 32 clustered cluster VBN 10_1101-2021_01_06_425581 159 33 in in IN 10_1101-2021_01_06_425581 159 34 the the DT 10_1101-2021_01_06_425581 159 35 center center NN 10_1101-2021_01_06_425581 159 36 of of IN 10_1101-2021_01_06_425581 159 37 the the DT 10_1101-2021_01_06_425581 159 38 embryo embryo NN 10_1101-2021_01_06_425581 159 39 , , , 10_1101-2021_01_06_425581 159 40 while while IN 10_1101-2021_01_06_425581 159 41 cells cell NNS 10_1101-2021_01_06_425581 159 42 that that WDT 10_1101-2021_01_06_425581 159 43 are be VBP 10_1101-2021_01_06_425581 159 44 disconnected disconnect VBN 10_1101-2021_01_06_425581 159 45 based base VBN 10_1101-2021_01_06_425581 159 46 on on IN 10_1101-2021_01_06_425581 159 47 our -PRON- PRP$ 10_1101-2021_01_06_425581 159 48 connectivity connectivity NN 10_1101-2021_01_06_425581 159 49 threshold threshold NN 10_1101-2021_01_06_425581 159 50 exist exist VBP 10_1101-2021_01_06_425581 159 51 on on IN 10_1101-2021_01_06_425581 159 52 the the DT 10_1101-2021_01_06_425581 159 53 edges edge NNS 10_1101-2021_01_06_425581 159 54 of of IN 10_1101-2021_01_06_425581 159 55 the the DT 10_1101-2021_01_06_425581 159 56 embryo embryo NN 10_1101-2021_01_06_425581 159 57 . . . 10_1101-2021_01_06_425581 160 1 Importantly importantly RB 10_1101-2021_01_06_425581 160 2 , , , 10_1101-2021_01_06_425581 160 3 it -PRON- PRP 10_1101-2021_01_06_425581 160 4 appears appear VBZ 10_1101-2021_01_06_425581 160 5 that that IN 10_1101-2021_01_06_425581 160 6 cells cell NNS 10_1101-2021_01_06_425581 160 7 are be VBP 10_1101-2021_01_06_425581 160 8 more more RBR 10_1101-2021_01_06_425581 160 9 densely densely RB 10_1101-2021_01_06_425581 160 10 clustered clustered JJ 10_1101-2021_01_06_425581 160 11 toward toward IN 10_1101-2021_01_06_425581 160 12 the the DT 10_1101-2021_01_06_425581 160 13 center center NN 10_1101-2021_01_06_425581 160 14 of of IN 10_1101-2021_01_06_425581 160 15 the the DT 10_1101-2021_01_06_425581 160 16 6 6 CD 10_1101-2021_01_06_425581 160 17 .CC .cc SYM 10_1101-2021_01_06_425581 160 18 - - HYPH 10_1101-2021_01_06_425581 160 19 BY BY NNP 10_1101-2021_01_06_425581 160 20 - - HYPH 10_1101-2021_01_06_425581 160 21 NC NC NNP 10_1101-2021_01_06_425581 160 22 4.0 4.0 CD 10_1101-2021_01_06_425581 160 23 International international JJ 10_1101-2021_01_06_425581 160 24 licensemade licensemade NN 10_1101-2021_01_06_425581 160 25 available available JJ 10_1101-2021_01_06_425581 160 26 under under IN 10_1101-2021_01_06_425581 160 27 a a DT 10_1101-2021_01_06_425581 160 28 ( ( -LRB- 10_1101-2021_01_06_425581 160 29 which which WDT 10_1101-2021_01_06_425581 160 30 was be VBD 10_1101-2021_01_06_425581 160 31 not not RB 10_1101-2021_01_06_425581 160 32 certified certify VBN 10_1101-2021_01_06_425581 160 33 by by IN 10_1101-2021_01_06_425581 160 34 peer peer NN 10_1101-2021_01_06_425581 160 35 review review NN 10_1101-2021_01_06_425581 160 36 ) ) -RRB- 10_1101-2021_01_06_425581 160 37 is be VBZ 10_1101-2021_01_06_425581 160 38 the the DT 10_1101-2021_01_06_425581 160 39 author author NN 10_1101-2021_01_06_425581 160 40 / / SYM 10_1101-2021_01_06_425581 160 41 funder funder NN 10_1101-2021_01_06_425581 160 42 , , , 10_1101-2021_01_06_425581 160 43 who who WP 10_1101-2021_01_06_425581 160 44 has have VBZ 10_1101-2021_01_06_425581 160 45 granted grant VBN 10_1101-2021_01_06_425581 160 46 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 160 47 a a DT 10_1101-2021_01_06_425581 160 48 license license NN 10_1101-2021_01_06_425581 160 49 to to TO 10_1101-2021_01_06_425581 160 50 display display VB 10_1101-2021_01_06_425581 160 51 the the DT 10_1101-2021_01_06_425581 160 52 preprint preprint NN 10_1101-2021_01_06_425581 160 53 in in IN 10_1101-2021_01_06_425581 160 54 perpetuity perpetuity NN 10_1101-2021_01_06_425581 160 55 . . . 10_1101-2021_01_06_425581 161 1 It -PRON- PRP 10_1101-2021_01_06_425581 161 2 is be VBZ 10_1101-2021_01_06_425581 161 3 The the DT 10_1101-2021_01_06_425581 161 4 copyright copyright NN 10_1101-2021_01_06_425581 161 5 holder holder NN 10_1101-2021_01_06_425581 161 6 for for IN 10_1101-2021_01_06_425581 161 7 this this DT 10_1101-2021_01_06_425581 161 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 161 9 version version NN 10_1101-2021_01_06_425581 161 10 posted post VBD 10_1101-2021_01_06_425581 161 11 January January NNP 10_1101-2021_01_06_425581 161 12 8 8 CD 10_1101-2021_01_06_425581 161 13 , , , 10_1101-2021_01_06_425581 161 14 2021 2021 CD 10_1101-2021_01_06_425581 161 15 . . . 10_1101-2021_01_06_425581 161 16 ; ; : 10_1101-2021_01_06_425581 161 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 161 18 : : : 10_1101-2021_01_06_425581 161 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 161 20 preprint preprint NN 10_1101-2021_01_06_425581 161 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 NNP 10_1101-2021_01_06_425581 161 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 161 23 embryo embryo NNP 10_1101-2021_01_06_425581 161 24 early early RB 10_1101-2021_01_06_425581 161 25 at at IN 10_1101-2021_01_06_425581 161 26 the the DT 10_1101-2021_01_06_425581 161 27 earliest early JJS 10_1101-2021_01_06_425581 161 28 stages stage NNS 10_1101-2021_01_06_425581 161 29 of of IN 10_1101-2021_01_06_425581 161 30 development development NN 10_1101-2021_01_06_425581 161 31 . . . 10_1101-2021_01_06_425581 162 1 These these DT 10_1101-2021_01_06_425581 162 2 dense dense JJ 10_1101-2021_01_06_425581 162 3 clusters cluster NNS 10_1101-2021_01_06_425581 162 4 are be VBP 10_1101-2021_01_06_425581 162 5 likely likely RB 10_1101-2021_01_06_425581 162 6 the the DT 10_1101-2021_01_06_425581 162 7 product product NN 10_1101-2021_01_06_425581 162 8 of of IN 10_1101-2021_01_06_425581 162 9 cell cell NN 10_1101-2021_01_06_425581 162 10 division division NN 10_1101-2021_01_06_425581 162 11 fluctuations fluctuation NNS 10_1101-2021_01_06_425581 162 12 shown show VBN 10_1101-2021_01_06_425581 162 13 in in IN 10_1101-2021_01_06_425581 162 14 Figures Figures NNP 10_1101-2021_01_06_425581 162 15 3 3 CD 10_1101-2021_01_06_425581 162 16 and and CC 10_1101-2021_01_06_425581 162 17 4 4 CD 10_1101-2021_01_06_425581 162 18 . . . 10_1101-2021_01_06_425581 163 1 Figure figure NN 10_1101-2021_01_06_425581 163 2 4 4 CD 10_1101-2021_01_06_425581 163 3 . . . 10_1101-2021_01_06_425581 164 1 Relative relative JJ 10_1101-2021_01_06_425581 164 2 frequency frequency NN 10_1101-2021_01_06_425581 164 3 of of IN 10_1101-2021_01_06_425581 164 4 birth birth NN 10_1101-2021_01_06_425581 164 5 rate rate NN 10_1101-2021_01_06_425581 164 6 across across IN 10_1101-2021_01_06_425581 164 7 developmental developmental JJ 10_1101-2021_01_06_425581 164 8 time time NN 10_1101-2021_01_06_425581 164 9 in in IN 10_1101-2021_01_06_425581 164 10 ​D. ​D. NNP 10_1101-2021_01_06_425581 165 1 rerio​. rerio​. ADD 10_1101-2021_01_06_425581 166 1 Histogram Histogram NNP 10_1101-2021_01_06_425581 166 2 demonstrates demonstrate VBZ 10_1101-2021_01_06_425581 166 3 the the DT 10_1101-2021_01_06_425581 166 4 distribution distribution NN 10_1101-2021_01_06_425581 166 5 of of IN 10_1101-2021_01_06_425581 166 6 cells cell NNS 10_1101-2021_01_06_425581 166 7 born bear VBN 10_1101-2021_01_06_425581 166 8 during during IN 10_1101-2021_01_06_425581 166 9 a a DT 10_1101-2021_01_06_425581 166 10 single single JJ 10_1101-2021_01_06_425581 166 11 sampling sampling NN 10_1101-2021_01_06_425581 166 12 time time NN 10_1101-2021_01_06_425581 166 13 point point NN 10_1101-2021_01_06_425581 166 14 . . . 10_1101-2021_01_06_425581 167 1 Numeric Numeric NNP 10_1101-2021_01_06_425581 167 2 Embryo Embryo NNP 10_1101-2021_01_06_425581 167 3 Experiments experiment VBZ 10_1101-2021_01_06_425581 167 4 A a DT 10_1101-2021_01_06_425581 167 5 numeric numeric JJ 10_1101-2021_01_06_425581 167 6 embryo embryo NN 10_1101-2021_01_06_425581 167 7 ( ( -LRB- 10_1101-2021_01_06_425581 167 8 or or CC 10_1101-2021_01_06_425581 167 9 perhaps perhaps RB 10_1101-2021_01_06_425581 167 10 more more RBR 10_1101-2021_01_06_425581 167 11 accurately accurately RB 10_1101-2021_01_06_425581 167 12 a a DT 10_1101-2021_01_06_425581 167 13 numeric numeric JJ 10_1101-2021_01_06_425581 167 14 one one NN 10_1101-2021_01_06_425581 167 15 ) ) -RRB- 10_1101-2021_01_06_425581 167 16 allows allow VBZ 10_1101-2021_01_06_425581 167 17 us -PRON- PRP 10_1101-2021_01_06_425581 167 18 to to TO 10_1101-2021_01_06_425581 167 19 understand understand VB 10_1101-2021_01_06_425581 167 20 the the DT 10_1101-2021_01_06_425581 167 21 fundamental fundamental JJ 10_1101-2021_01_06_425581 167 22 features feature NNS 10_1101-2021_01_06_425581 167 23 of of IN 10_1101-2021_01_06_425581 167 24 cell cell NN 10_1101-2021_01_06_425581 167 25 division division NN 10_1101-2021_01_06_425581 167 26 events event NNS 10_1101-2021_01_06_425581 167 27 relative relative JJ 10_1101-2021_01_06_425581 167 28 to to IN 10_1101-2021_01_06_425581 167 29 the the DT 10_1101-2021_01_06_425581 167 30 efficiency efficiency NN 10_1101-2021_01_06_425581 167 31 of of IN 10_1101-2021_01_06_425581 167 32 their -PRON- PRP$ 10_1101-2021_01_06_425581 167 33 timing timing NN 10_1101-2021_01_06_425581 167 34 . . . 10_1101-2021_01_06_425581 168 1 Is be VBZ 10_1101-2021_01_06_425581 168 2 one one CD 10_1101-2021_01_06_425581 168 3 timing timing NN 10_1101-2021_01_06_425581 168 4 scheme scheme NN 10_1101-2021_01_06_425581 168 5 superior superior JJ 10_1101-2021_01_06_425581 168 6 to to IN 10_1101-2021_01_06_425581 168 7 another another DT 10_1101-2021_01_06_425581 168 8 ? ? . 10_1101-2021_01_06_425581 169 1 We -PRON- PRP 10_1101-2021_01_06_425581 169 2 know know VBP 10_1101-2021_01_06_425581 169 3 that that IN 10_1101-2021_01_06_425581 169 4 in in IN 10_1101-2021_01_06_425581 169 5 real real JJ 10_1101-2021_01_06_425581 169 6 ( ( -LRB- 10_1101-2021_01_06_425581 169 7 biological biological JJ 10_1101-2021_01_06_425581 169 8 ) ) -RRB- 10_1101-2021_01_06_425581 169 9 lineage lineage NN 10_1101-2021_01_06_425581 169 10 trees tree NNS 10_1101-2021_01_06_425581 169 11 that that WDT 10_1101-2021_01_06_425581 169 12 cell cell NN 10_1101-2021_01_06_425581 169 13 divisions division NNS 10_1101-2021_01_06_425581 169 14 do do VBP 10_1101-2021_01_06_425581 169 15 not not RB 10_1101-2021_01_06_425581 169 16 occur occur VB 10_1101-2021_01_06_425581 169 17 at at IN 10_1101-2021_01_06_425581 169 18 a a DT 10_1101-2021_01_06_425581 169 19 completely completely RB 10_1101-2021_01_06_425581 169 20 regular regular JJ 10_1101-2021_01_06_425581 169 21 rate rate NN 10_1101-2021_01_06_425581 169 22 . . . 10_1101-2021_01_06_425581 170 1 Are be VBP 10_1101-2021_01_06_425581 170 2 there there EX 10_1101-2021_01_06_425581 170 3 advantages advantage NNS 10_1101-2021_01_06_425581 170 4 in in IN 10_1101-2021_01_06_425581 170 5 one one CD 10_1101-2021_01_06_425581 170 6 particular particular JJ 10_1101-2021_01_06_425581 170 7 statistical statistical JJ 10_1101-2021_01_06_425581 170 8 signature signature NN 10_1101-2021_01_06_425581 170 9 over over IN 10_1101-2021_01_06_425581 170 10 another another DT 10_1101-2021_01_06_425581 170 11 , , , 10_1101-2021_01_06_425581 170 12 particularly particularly RB 10_1101-2021_01_06_425581 170 13 when when WRB 10_1101-2021_01_06_425581 170 14 comparing compare VBG 10_1101-2021_01_06_425581 170 15 it -PRON- PRP 10_1101-2021_01_06_425581 170 16 to to IN 10_1101-2021_01_06_425581 170 17 an an DT 10_1101-2021_01_06_425581 170 18 artificial artificial JJ 10_1101-2021_01_06_425581 170 19 ( ( -LRB- 10_1101-2021_01_06_425581 170 20 regular regular JJ 10_1101-2021_01_06_425581 170 21 ) ) -RRB- 10_1101-2021_01_06_425581 170 22 scheme scheme NN 10_1101-2021_01_06_425581 170 23 ? ? . 10_1101-2021_01_06_425581 171 1 Table table NN 10_1101-2021_01_06_425581 171 2 1 1 CD 10_1101-2021_01_06_425581 171 3 shows show VBZ 10_1101-2021_01_06_425581 171 4 a a DT 10_1101-2021_01_06_425581 171 5 summary summary NN 10_1101-2021_01_06_425581 171 6 of of IN 10_1101-2021_01_06_425581 171 7 how how WRB 10_1101-2021_01_06_425581 171 8 this this DT 10_1101-2021_01_06_425581 171 9 simulation simulation NN 10_1101-2021_01_06_425581 171 10 is be VBZ 10_1101-2021_01_06_425581 171 11 constructed construct VBN 10_1101-2021_01_06_425581 171 12 . . . 10_1101-2021_01_06_425581 172 1 Table table NN 10_1101-2021_01_06_425581 172 2 1 1 CD 10_1101-2021_01_06_425581 172 3 . . . 10_1101-2021_01_06_425581 173 1 An an DT 10_1101-2021_01_06_425581 173 2 example example NN 10_1101-2021_01_06_425581 173 3 of of IN 10_1101-2021_01_06_425581 173 4 our -PRON- PRP$ 10_1101-2021_01_06_425581 173 5 numeric numeric JJ 10_1101-2021_01_06_425581 173 6 simulation simulation NN 10_1101-2021_01_06_425581 173 7 , , , 10_1101-2021_01_06_425581 173 8 with with IN 10_1101-2021_01_06_425581 173 9 variable variable JJ 10_1101-2021_01_06_425581 173 10 and and CC 10_1101-2021_01_06_425581 173 11 sample sample NN 10_1101-2021_01_06_425581 173 12 values value NNS 10_1101-2021_01_06_425581 173 13 . . . 10_1101-2021_01_06_425581 174 1 We -PRON- PRP 10_1101-2021_01_06_425581 174 2 use use VBP 10_1101-2021_01_06_425581 174 3 the the DT 10_1101-2021_01_06_425581 174 4 uniform uniform JJ 10_1101-2021_01_06_425581 174 5 distribution distribution NN 10_1101-2021_01_06_425581 174 6 as as IN 10_1101-2021_01_06_425581 174 7 the the DT 10_1101-2021_01_06_425581 174 8 basis basis NN 10_1101-2021_01_06_425581 174 9 for for IN 10_1101-2021_01_06_425581 174 10 Poisson Poisson NNP 10_1101-2021_01_06_425581 174 11 noise noise NN 10_1101-2021_01_06_425581 174 12 , , , 10_1101-2021_01_06_425581 174 13 which which WDT 10_1101-2021_01_06_425581 174 14 helps help VBZ 10_1101-2021_01_06_425581 174 15 to to TO 10_1101-2021_01_06_425581 174 16 execute execute VB 10_1101-2021_01_06_425581 174 17 things thing NNS 10_1101-2021_01_06_425581 174 18 a a DT 10_1101-2021_01_06_425581 174 19 bit bit NN 10_1101-2021_01_06_425581 174 20 faster fast RBR 10_1101-2021_01_06_425581 174 21 on on IN 10_1101-2021_01_06_425581 174 22 average average JJ 10_1101-2021_01_06_425581 174 23 . . . 10_1101-2021_01_06_425581 175 1 Compare compare VB 10_1101-2021_01_06_425581 175 2 this this DT 10_1101-2021_01_06_425581 175 3 to to TO 10_1101-2021_01_06_425581 175 4 uniform uniform JJ 10_1101-2021_01_06_425581 175 5 division division NN 10_1101-2021_01_06_425581 175 6 times time NNS 10_1101-2021_01_06_425581 175 7 such such JJ 10_1101-2021_01_06_425581 175 8 as as IN 10_1101-2021_01_06_425581 175 9 a a DT 10_1101-2021_01_06_425581 175 10 division division NN 10_1101-2021_01_06_425581 175 11 event event NN 10_1101-2021_01_06_425581 175 12 occurring occur VBG 10_1101-2021_01_06_425581 175 13 once once RB 10_1101-2021_01_06_425581 175 14 every every DT 10_1101-2021_01_06_425581 175 15 20 20 CD 10_1101-2021_01_06_425581 175 16 units unit NNS 10_1101-2021_01_06_425581 175 17 of of IN 10_1101-2021_01_06_425581 175 18 time time NN 10_1101-2021_01_06_425581 175 19 . . . 10_1101-2021_01_06_425581 176 1 Generated generate VBD 10_1101-2021_01_06_425581 176 2 Poisson Poisson NNP 10_1101-2021_01_06_425581 176 3 Interval Interval NNP 10_1101-2021_01_06_425581 176 4 represents represent VBZ 10_1101-2021_01_06_425581 176 5 the the DT 10_1101-2021_01_06_425581 176 6 size size NN 10_1101-2021_01_06_425581 176 7 of of IN 10_1101-2021_01_06_425581 176 8 the the DT 10_1101-2021_01_06_425581 176 9 interval interval NN 10_1101-2021_01_06_425581 176 10 between between IN 10_1101-2021_01_06_425581 176 11 division division NN 10_1101-2021_01_06_425581 176 12 events event NNS 10_1101-2021_01_06_425581 176 13 , , , 10_1101-2021_01_06_425581 176 14 while while IN 10_1101-2021_01_06_425581 176 15 division division NN 10_1101-2021_01_06_425581 176 16 Interval interval NN 10_1101-2021_01_06_425581 176 17 7 7 CD 10_1101-2021_01_06_425581 176 18 Developmental Developmental NNP 10_1101-2021_01_06_425581 176 19 Time Time NNP 10_1101-2021_01_06_425581 176 20 Unit Unit NNP 10_1101-2021_01_06_425581 176 21 Division Division NNP 10_1101-2021_01_06_425581 176 22 Time Time NNP 10_1101-2021_01_06_425581 176 23 ( ( -LRB- 10_1101-2021_01_06_425581 176 24 AU AU NNP 10_1101-2021_01_06_425581 176 25 ) ) -RRB- 10_1101-2021_01_06_425581 176 26 Generated generate VBD 10_1101-2021_01_06_425581 176 27 Poisson Poisson NNP 10_1101-2021_01_06_425581 176 28 Interval Interval NNP 10_1101-2021_01_06_425581 176 29 Division Division NNP 10_1101-2021_01_06_425581 176 30 Interval Interval NNP 10_1101-2021_01_06_425581 176 31 0 0 CD 10_1101-2021_01_06_425581 176 32 0 0 CD 10_1101-2021_01_06_425581 176 33 0 0 CD 10_1101-2021_01_06_425581 176 34 0 0 CD 10_1101-2021_01_06_425581 176 35 1 1 CD 10_1101-2021_01_06_425581 176 36 1 1 CD 10_1101-2021_01_06_425581 176 37 1 1 CD 10_1101-2021_01_06_425581 176 38 0 0 CD 10_1101-2021_01_06_425581 176 39 2 2 CD 10_1101-2021_01_06_425581 176 40 0 0 CD 10_1101-2021_01_06_425581 176 41 2 2 CD 10_1101-2021_01_06_425581 176 42 2 2 CD 10_1101-2021_01_06_425581 176 43 3 3 CD 10_1101-2021_01_06_425581 176 44 1 1 CD 10_1101-2021_01_06_425581 176 45 3 3 CD 10_1101-2021_01_06_425581 176 46 0 0 CD 10_1101-2021_01_06_425581 176 47 .CC .CC NFP 10_1101-2021_01_06_425581 176 48 - - HYPH 10_1101-2021_01_06_425581 176 49 BY BY NNP 10_1101-2021_01_06_425581 176 50 - - HYPH 10_1101-2021_01_06_425581 176 51 NC NC NNP 10_1101-2021_01_06_425581 176 52 4.0 4.0 CD 10_1101-2021_01_06_425581 176 53 International international JJ 10_1101-2021_01_06_425581 176 54 licensemade licensemade NN 10_1101-2021_01_06_425581 176 55 available available JJ 10_1101-2021_01_06_425581 176 56 under under IN 10_1101-2021_01_06_425581 176 57 a a DT 10_1101-2021_01_06_425581 176 58 ( ( -LRB- 10_1101-2021_01_06_425581 176 59 which which WDT 10_1101-2021_01_06_425581 176 60 was be VBD 10_1101-2021_01_06_425581 176 61 not not RB 10_1101-2021_01_06_425581 176 62 certified certify VBN 10_1101-2021_01_06_425581 176 63 by by IN 10_1101-2021_01_06_425581 176 64 peer peer NN 10_1101-2021_01_06_425581 176 65 review review NN 10_1101-2021_01_06_425581 176 66 ) ) -RRB- 10_1101-2021_01_06_425581 176 67 is be VBZ 10_1101-2021_01_06_425581 176 68 the the DT 10_1101-2021_01_06_425581 176 69 author author NN 10_1101-2021_01_06_425581 176 70 / / SYM 10_1101-2021_01_06_425581 176 71 funder funder NN 10_1101-2021_01_06_425581 176 72 , , , 10_1101-2021_01_06_425581 176 73 who who WP 10_1101-2021_01_06_425581 176 74 has have VBZ 10_1101-2021_01_06_425581 176 75 granted grant VBN 10_1101-2021_01_06_425581 176 76 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 176 77 a a DT 10_1101-2021_01_06_425581 176 78 license license NN 10_1101-2021_01_06_425581 176 79 to to TO 10_1101-2021_01_06_425581 176 80 display display VB 10_1101-2021_01_06_425581 176 81 the the DT 10_1101-2021_01_06_425581 176 82 preprint preprint NN 10_1101-2021_01_06_425581 176 83 in in IN 10_1101-2021_01_06_425581 176 84 perpetuity perpetuity NN 10_1101-2021_01_06_425581 176 85 . . . 10_1101-2021_01_06_425581 177 1 It -PRON- PRP 10_1101-2021_01_06_425581 177 2 is be VBZ 10_1101-2021_01_06_425581 177 3 The the DT 10_1101-2021_01_06_425581 177 4 copyright copyright NN 10_1101-2021_01_06_425581 177 5 holder holder NN 10_1101-2021_01_06_425581 177 6 for for IN 10_1101-2021_01_06_425581 177 7 this this DT 10_1101-2021_01_06_425581 177 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 177 9 version version NN 10_1101-2021_01_06_425581 177 10 posted post VBD 10_1101-2021_01_06_425581 177 11 January January NNP 10_1101-2021_01_06_425581 177 12 8 8 CD 10_1101-2021_01_06_425581 177 13 , , , 10_1101-2021_01_06_425581 177 14 2021 2021 CD 10_1101-2021_01_06_425581 177 15 . . . 10_1101-2021_01_06_425581 177 16 ; ; : 10_1101-2021_01_06_425581 177 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 177 18 : : : 10_1101-2021_01_06_425581 177 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 177 20 preprint preprint NN 10_1101-2021_01_06_425581 177 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 177 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 177 23 represents represent VBZ 10_1101-2021_01_06_425581 177 24 when when WRB 10_1101-2021_01_06_425581 177 25 the the DT 10_1101-2021_01_06_425581 177 26 event event NN 10_1101-2021_01_06_425581 177 27 occurs occur VBZ 10_1101-2021_01_06_425581 177 28 in in IN 10_1101-2021_01_06_425581 177 29 developmental developmental JJ 10_1101-2021_01_06_425581 177 30 time time NN 10_1101-2021_01_06_425581 177 31 . . . 10_1101-2021_01_06_425581 178 1 Our -PRON- PRP$ 10_1101-2021_01_06_425581 178 2 timing timing NN 10_1101-2021_01_06_425581 178 3 data datum NNS 10_1101-2021_01_06_425581 178 4 can can MD 10_1101-2021_01_06_425581 178 5 be be VB 10_1101-2021_01_06_425581 178 6 modeled model VBN 10_1101-2021_01_06_425581 178 7 as as IN 10_1101-2021_01_06_425581 178 8 branches branch NNS 10_1101-2021_01_06_425581 178 9 of of IN 10_1101-2021_01_06_425581 178 10 a a DT 10_1101-2021_01_06_425581 178 11 binary binary JJ 10_1101-2021_01_06_425581 178 12 tree tree NN 10_1101-2021_01_06_425581 178 13 which which WDT 10_1101-2021_01_06_425581 178 14 are be VBP 10_1101-2021_01_06_425581 178 15 generated generate VBN 10_1101-2021_01_06_425581 178 16 every every DT 10_1101-2021_01_06_425581 178 17 ​n ​n NN 10_1101-2021_01_06_425581 178 18 units unit NNS 10_1101-2021_01_06_425581 178 19 of of IN 10_1101-2021_01_06_425581 178 20 developmental developmental JJ 10_1101-2021_01_06_425581 178 21 time time NN 10_1101-2021_01_06_425581 178 22 . . . 10_1101-2021_01_06_425581 179 1 The the DT 10_1101-2021_01_06_425581 179 2 intervals interval NNS 10_1101-2021_01_06_425581 179 3 between between IN 10_1101-2021_01_06_425581 179 4 ​n​1​ ​n​1​ NNP 10_1101-2021_01_06_425581 179 5 , , , 10_1101-2021_01_06_425581 179 6 n​2​ n​2​ NNP 10_1101-2021_01_06_425581 179 7 , , , 10_1101-2021_01_06_425581 179 8 n​3​ n​3​ NNP 10_1101-2021_01_06_425581 179 9 , , , 10_1101-2021_01_06_425581 179 10 … … NFP 10_1101-2021_01_06_425581 179 11 . . . 10_1101-2021_01_06_425581 180 1 n​t n​t RB 10_1101-2021_01_06_425581 180 2 are be VBP 10_1101-2021_01_06_425581 180 3 determined determine VBN 10_1101-2021_01_06_425581 180 4 by by IN 10_1101-2021_01_06_425581 180 5 a a DT 10_1101-2021_01_06_425581 180 6 probability probability NN 10_1101-2021_01_06_425581 180 7 distribution distribution NN 10_1101-2021_01_06_425581 180 8 , , , 10_1101-2021_01_06_425581 180 9 which which WDT 10_1101-2021_01_06_425581 180 10 can can MD 10_1101-2021_01_06_425581 180 11 be be VB 10_1101-2021_01_06_425581 180 12 uniform uniform JJ 10_1101-2021_01_06_425581 180 13 ( ( -LRB- 10_1101-2021_01_06_425581 180 14 every every DT 10_1101-2021_01_06_425581 180 15 branching branch VBG 10_1101-2021_01_06_425581 180 16 event event NN 10_1101-2021_01_06_425581 180 17 occurring occur VBG 10_1101-2021_01_06_425581 180 18 at at IN 10_1101-2021_01_06_425581 180 19 completely completely RB 10_1101-2021_01_06_425581 180 20 regular regular JJ 10_1101-2021_01_06_425581 180 21 intervals interval NNS 10_1101-2021_01_06_425581 180 22 ) ) -RRB- 10_1101-2021_01_06_425581 180 23 , , , 10_1101-2021_01_06_425581 180 24 or or CC 10_1101-2021_01_06_425581 180 25 a a DT 10_1101-2021_01_06_425581 180 26 Poisson Poisson NNP 10_1101-2021_01_06_425581 180 27 distribution distribution NN 10_1101-2021_01_06_425581 180 28 ( ( -LRB- 10_1101-2021_01_06_425581 180 29 where where WRB 10_1101-2021_01_06_425581 180 30 branching branch VBG 10_1101-2021_01_06_425581 180 31 events event NNS 10_1101-2021_01_06_425581 180 32 are be VBP 10_1101-2021_01_06_425581 180 33 distributed distribute VBN 10_1101-2021_01_06_425581 180 34 in in IN 10_1101-2021_01_06_425581 180 35 an an DT 10_1101-2021_01_06_425581 180 36 exponential exponential JJ 10_1101-2021_01_06_425581 180 37 fashion fashion NN 10_1101-2021_01_06_425581 180 38 ) ) -RRB- 10_1101-2021_01_06_425581 180 39 . . . 10_1101-2021_01_06_425581 181 1 Figure figure NN 10_1101-2021_01_06_425581 181 2 5 5 CD 10_1101-2021_01_06_425581 181 3 . . . 10_1101-2021_01_06_425581 182 1 Interval interval JJ 10_1101-2021_01_06_425581 182 2 size size NN 10_1101-2021_01_06_425581 182 3 of of IN 10_1101-2021_01_06_425581 182 4 peaks peak NNS 10_1101-2021_01_06_425581 182 5 in in IN 10_1101-2021_01_06_425581 182 6 cell cell NN 10_1101-2021_01_06_425581 182 7 division division NN 10_1101-2021_01_06_425581 182 8 for for IN 10_1101-2021_01_06_425581 182 9 all all DT 10_1101-2021_01_06_425581 182 10 developmental developmental JJ 10_1101-2021_01_06_425581 182 11 cells cell NNS 10_1101-2021_01_06_425581 182 12 in in IN 10_1101-2021_01_06_425581 182 13 ​C. ​C. NNP 10_1101-2021_01_06_425581 183 1 elegans elegans NNPS 10_1101-2021_01_06_425581 183 2 ​(top ​(top NNP 10_1101-2021_01_06_425581 183 3 ) ) -RRB- 10_1101-2021_01_06_425581 183 4 and and CC 10_1101-2021_01_06_425581 183 5 first first JJ 10_1101-2021_01_06_425581 183 6 206 206 CD 10_1101-2021_01_06_425581 183 7 minutes minute NNS 10_1101-2021_01_06_425581 183 8 of of IN 10_1101-2021_01_06_425581 183 9 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 183 10 ( ( -LRB- 10_1101-2021_01_06_425581 183 11 bottom bottom NN 10_1101-2021_01_06_425581 183 12 ) ) -RRB- 10_1101-2021_01_06_425581 183 13 . . . 10_1101-2021_01_06_425581 184 1 ​C. ​c. ADD 10_1101-2021_01_06_425581 185 1 elegans elegans NNPS 10_1101-2021_01_06_425581 185 2 sampling sampling NN 10_1101-2021_01_06_425581 185 3 time time NN 10_1101-2021_01_06_425581 185 4 points point NNS 10_1101-2021_01_06_425581 185 5 correspond correspond VBP 10_1101-2021_01_06_425581 185 6 to to IN 10_1101-2021_01_06_425581 185 7 most most JJS 10_1101-2021_01_06_425581 185 8 of of IN 10_1101-2021_01_06_425581 185 9 the the DT 10_1101-2021_01_06_425581 185 10 pre pre JJ 10_1101-2021_01_06_425581 185 11 - - JJ 10_1101-2021_01_06_425581 185 12 hatch hatch JJ 10_1101-2021_01_06_425581 185 13 developmental developmental JJ 10_1101-2021_01_06_425581 185 14 period period NN 10_1101-2021_01_06_425581 185 15 ( ( -LRB- 10_1101-2021_01_06_425581 185 16 660 660 CD 10_1101-2021_01_06_425581 185 17 minutes minute NNS 10_1101-2021_01_06_425581 185 18 8 8 CD 10_1101-2021_01_06_425581 185 19 .CC .CC : 10_1101-2021_01_06_425581 185 20 - - HYPH 10_1101-2021_01_06_425581 185 21 BY BY NNP 10_1101-2021_01_06_425581 185 22 - - HYPH 10_1101-2021_01_06_425581 185 23 NC NC NNP 10_1101-2021_01_06_425581 185 24 4.0 4.0 CD 10_1101-2021_01_06_425581 185 25 International international JJ 10_1101-2021_01_06_425581 185 26 licensemade licensemade NN 10_1101-2021_01_06_425581 185 27 available available JJ 10_1101-2021_01_06_425581 185 28 under under IN 10_1101-2021_01_06_425581 185 29 a a DT 10_1101-2021_01_06_425581 185 30 ( ( -LRB- 10_1101-2021_01_06_425581 185 31 which which WDT 10_1101-2021_01_06_425581 185 32 was be VBD 10_1101-2021_01_06_425581 185 33 not not RB 10_1101-2021_01_06_425581 185 34 certified certify VBN 10_1101-2021_01_06_425581 185 35 by by IN 10_1101-2021_01_06_425581 185 36 peer peer NN 10_1101-2021_01_06_425581 185 37 review review NN 10_1101-2021_01_06_425581 185 38 ) ) -RRB- 10_1101-2021_01_06_425581 185 39 is be VBZ 10_1101-2021_01_06_425581 185 40 the the DT 10_1101-2021_01_06_425581 185 41 author author NN 10_1101-2021_01_06_425581 185 42 / / SYM 10_1101-2021_01_06_425581 185 43 funder funder NN 10_1101-2021_01_06_425581 185 44 , , , 10_1101-2021_01_06_425581 185 45 who who WP 10_1101-2021_01_06_425581 185 46 has have VBZ 10_1101-2021_01_06_425581 185 47 granted grant VBN 10_1101-2021_01_06_425581 185 48 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 185 49 a a DT 10_1101-2021_01_06_425581 185 50 license license NN 10_1101-2021_01_06_425581 185 51 to to TO 10_1101-2021_01_06_425581 185 52 display display VB 10_1101-2021_01_06_425581 185 53 the the DT 10_1101-2021_01_06_425581 185 54 preprint preprint NN 10_1101-2021_01_06_425581 185 55 in in IN 10_1101-2021_01_06_425581 185 56 perpetuity perpetuity NN 10_1101-2021_01_06_425581 185 57 . . . 10_1101-2021_01_06_425581 186 1 It -PRON- PRP 10_1101-2021_01_06_425581 186 2 is be VBZ 10_1101-2021_01_06_425581 186 3 The the DT 10_1101-2021_01_06_425581 186 4 copyright copyright NN 10_1101-2021_01_06_425581 186 5 holder holder NN 10_1101-2021_01_06_425581 186 6 for for IN 10_1101-2021_01_06_425581 186 7 this this DT 10_1101-2021_01_06_425581 186 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 186 9 version version NN 10_1101-2021_01_06_425581 186 10 posted post VBD 10_1101-2021_01_06_425581 186 11 January January NNP 10_1101-2021_01_06_425581 186 12 8 8 CD 10_1101-2021_01_06_425581 186 13 , , , 10_1101-2021_01_06_425581 186 14 2021 2021 CD 10_1101-2021_01_06_425581 186 15 . . . 10_1101-2021_01_06_425581 186 16 ; ; : 10_1101-2021_01_06_425581 186 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 186 18 : : : 10_1101-2021_01_06_425581 186 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 186 20 preprint preprint NN 10_1101-2021_01_06_425581 186 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 186 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 186 23 post post NNP 10_1101-2021_01_06_425581 186 24 - - JJ 10_1101-2021_01_06_425581 186 25 fertilization fertilization NNP 10_1101-2021_01_06_425581 186 26 ) ) -RRB- 10_1101-2021_01_06_425581 186 27 , , , 10_1101-2021_01_06_425581 186 28 while while IN 10_1101-2021_01_06_425581 186 29 the the DT 10_1101-2021_01_06_425581 186 30 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 186 31 sampling sampling NN 10_1101-2021_01_06_425581 186 32 time time NN 10_1101-2021_01_06_425581 186 33 points point NNS 10_1101-2021_01_06_425581 186 34 correspond correspond VBP 10_1101-2021_01_06_425581 186 35 roughly roughly RB 10_1101-2021_01_06_425581 186 36 to to IN 10_1101-2021_01_06_425581 186 37 the the DT 10_1101-2021_01_06_425581 186 38 period period NN 10_1101-2021_01_06_425581 186 39 between between IN 10_1101-2021_01_06_425581 186 40 the the DT 10_1101-2021_01_06_425581 186 41 Zygote Zygote NNP 10_1101-2021_01_06_425581 186 42 and and CC 10_1101-2021_01_06_425581 186 43 the the DT 10_1101-2021_01_06_425581 186 44 oblong oblong JJ 10_1101-2021_01_06_425581 186 45 / / SYM 10_1101-2021_01_06_425581 186 46 sphere sphere JJ 10_1101-2021_01_06_425581 186 47 stages stage NNS 10_1101-2021_01_06_425581 186 48 of of IN 10_1101-2021_01_06_425581 186 49 the the DT 10_1101-2021_01_06_425581 186 50 Blastula Blastula NNP 10_1101-2021_01_06_425581 186 51 . . . 10_1101-2021_01_06_425581 187 1 Figure figure NN 10_1101-2021_01_06_425581 187 2 6 6 CD 10_1101-2021_01_06_425581 187 3 . . . 10_1101-2021_01_06_425581 188 1 TOP TOP NNP 10_1101-2021_01_06_425581 188 2 : : : 10_1101-2021_01_06_425581 188 3 an an DT 10_1101-2021_01_06_425581 188 4 embryo embryo NN 10_1101-2021_01_06_425581 188 5 networks network NNS 10_1101-2021_01_06_425581 188 6 for for IN 10_1101-2021_01_06_425581 188 7 the the DT 10_1101-2021_01_06_425581 188 8 ​D. ​D. NNP 10_1101-2021_01_06_425581 189 1 rerio rerio NNP 10_1101-2021_01_06_425581 189 2 embryo embryo NNP 10_1101-2021_01_06_425581 189 3 at at IN 10_1101-2021_01_06_425581 189 4 the the DT 10_1101-2021_01_06_425581 189 5 239 239 CD 10_1101-2021_01_06_425581 189 6 cell cell NN 10_1101-2021_01_06_425581 189 7 stage stage NN 10_1101-2021_01_06_425581 189 8 ( ( -LRB- 10_1101-2021_01_06_425581 189 9 all all DT 10_1101-2021_01_06_425581 189 10 cells cell NNS 10_1101-2021_01_06_425581 189 11 born bear VBN 10_1101-2021_01_06_425581 189 12 during during IN 10_1101-2021_01_06_425581 189 13 the the DT 10_1101-2021_01_06_425581 189 14 zygote zygote NN 10_1101-2021_01_06_425581 189 15 and and CC 10_1101-2021_01_06_425581 189 16 cleavage cleavage NN 10_1101-2021_01_06_425581 189 17 stages stage NNS 10_1101-2021_01_06_425581 189 18 ) ) -RRB- 10_1101-2021_01_06_425581 189 19 , , , 10_1101-2021_01_06_425581 189 20 with with IN 10_1101-2021_01_06_425581 189 21 920 920 CD 10_1101-2021_01_06_425581 189 22 edges edge NNS 10_1101-2021_01_06_425581 189 23 . . . 10_1101-2021_01_06_425581 190 1 The the DT 10_1101-2021_01_06_425581 190 2 edge edge NN 10_1101-2021_01_06_425581 190 3 threshold threshold NN 10_1101-2021_01_06_425581 190 4 is be VBZ 10_1101-2021_01_06_425581 190 5 an an DT 10_1101-2021_01_06_425581 190 6 embryo embryo NN 10_1101-2021_01_06_425581 190 7 distance distance NN 10_1101-2021_01_06_425581 190 8 of of IN 10_1101-2021_01_06_425581 190 9 0.05 0.05 CD 10_1101-2021_01_06_425581 190 10 . . . 10_1101-2021_01_06_425581 191 1 BOTTOM BOTTOM NNS 10_1101-2021_01_06_425581 191 2 : : : 10_1101-2021_01_06_425581 191 3 Cells cell NNS 10_1101-2021_01_06_425581 191 4 in in IN 10_1101-2021_01_06_425581 191 5 developmental developmental JJ 10_1101-2021_01_06_425581 191 6 location location NN 10_1101-2021_01_06_425581 191 7 color color NN 10_1101-2021_01_06_425581 191 8 - - HYPH 10_1101-2021_01_06_425581 191 9 coded code VBN 10_1101-2021_01_06_425581 191 10 by by IN 10_1101-2021_01_06_425581 191 11 status status NN 10_1101-2021_01_06_425581 191 12 in in IN 10_1101-2021_01_06_425581 191 13 the the DT 10_1101-2021_01_06_425581 191 14 network network NN 10_1101-2021_01_06_425581 191 15 . . . 10_1101-2021_01_06_425581 192 1 WHITE white JJ 10_1101-2021_01_06_425581 192 2 : : : 10_1101-2021_01_06_425581 192 3 all all DT 10_1101-2021_01_06_425581 192 4 cells cell NNS 10_1101-2021_01_06_425581 192 5 not not RB 10_1101-2021_01_06_425581 192 6 above above IN 10_1101-2021_01_06_425581 192 7 the the DT 10_1101-2021_01_06_425581 192 8 threshold threshold NN 10_1101-2021_01_06_425581 192 9 , , , 10_1101-2021_01_06_425581 192 10 RED RED NNP 10_1101-2021_01_06_425581 192 11 : : : 10_1101-2021_01_06_425581 192 12 9 9 CD 10_1101-2021_01_06_425581 192 13 .CC .CC : 10_1101-2021_01_06_425581 192 14 - - HYPH 10_1101-2021_01_06_425581 192 15 BY BY NNP 10_1101-2021_01_06_425581 192 16 - - HYPH 10_1101-2021_01_06_425581 192 17 NC NC NNP 10_1101-2021_01_06_425581 192 18 4.0 4.0 CD 10_1101-2021_01_06_425581 192 19 International international JJ 10_1101-2021_01_06_425581 192 20 licensemade licensemade NN 10_1101-2021_01_06_425581 192 21 available available JJ 10_1101-2021_01_06_425581 192 22 under under IN 10_1101-2021_01_06_425581 192 23 a a DT 10_1101-2021_01_06_425581 192 24 ( ( -LRB- 10_1101-2021_01_06_425581 192 25 which which WDT 10_1101-2021_01_06_425581 192 26 was be VBD 10_1101-2021_01_06_425581 192 27 not not RB 10_1101-2021_01_06_425581 192 28 certified certify VBN 10_1101-2021_01_06_425581 192 29 by by IN 10_1101-2021_01_06_425581 192 30 peer peer NN 10_1101-2021_01_06_425581 192 31 review review NN 10_1101-2021_01_06_425581 192 32 ) ) -RRB- 10_1101-2021_01_06_425581 192 33 is be VBZ 10_1101-2021_01_06_425581 192 34 the the DT 10_1101-2021_01_06_425581 192 35 author author NN 10_1101-2021_01_06_425581 192 36 / / SYM 10_1101-2021_01_06_425581 192 37 funder funder NN 10_1101-2021_01_06_425581 192 38 , , , 10_1101-2021_01_06_425581 192 39 who who WP 10_1101-2021_01_06_425581 192 40 has have VBZ 10_1101-2021_01_06_425581 192 41 granted grant VBN 10_1101-2021_01_06_425581 192 42 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 192 43 a a DT 10_1101-2021_01_06_425581 192 44 license license NN 10_1101-2021_01_06_425581 192 45 to to TO 10_1101-2021_01_06_425581 192 46 display display VB 10_1101-2021_01_06_425581 192 47 the the DT 10_1101-2021_01_06_425581 192 48 preprint preprint NN 10_1101-2021_01_06_425581 192 49 in in IN 10_1101-2021_01_06_425581 192 50 perpetuity perpetuity NN 10_1101-2021_01_06_425581 192 51 . . . 10_1101-2021_01_06_425581 193 1 It -PRON- PRP 10_1101-2021_01_06_425581 193 2 is be VBZ 10_1101-2021_01_06_425581 193 3 The the DT 10_1101-2021_01_06_425581 193 4 copyright copyright NN 10_1101-2021_01_06_425581 193 5 holder holder NN 10_1101-2021_01_06_425581 193 6 for for IN 10_1101-2021_01_06_425581 193 7 this this DT 10_1101-2021_01_06_425581 193 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 193 9 version version NN 10_1101-2021_01_06_425581 193 10 posted post VBD 10_1101-2021_01_06_425581 193 11 January January NNP 10_1101-2021_01_06_425581 193 12 8 8 CD 10_1101-2021_01_06_425581 193 13 , , , 10_1101-2021_01_06_425581 193 14 2021 2021 CD 10_1101-2021_01_06_425581 193 15 . . . 10_1101-2021_01_06_425581 193 16 ; ; : 10_1101-2021_01_06_425581 193 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 193 18 : : : 10_1101-2021_01_06_425581 193 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 193 20 preprint preprint NN 10_1101-2021_01_06_425581 193 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 193 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NN 10_1101-2021_01_06_425581 193 23 all all DT 10_1101-2021_01_06_425581 193 24 source source NN 10_1101-2021_01_06_425581 193 25 cells cell NNS 10_1101-2021_01_06_425581 193 26 with with IN 10_1101-2021_01_06_425581 193 27 at at RB 10_1101-2021_01_06_425581 193 28 least least RBS 10_1101-2021_01_06_425581 193 29 one one CD 10_1101-2021_01_06_425581 193 30 edge edge NN 10_1101-2021_01_06_425581 193 31 to to IN 10_1101-2021_01_06_425581 193 32 another another DT 10_1101-2021_01_06_425581 193 33 cell cell NN 10_1101-2021_01_06_425581 193 34 . . . 10_1101-2021_01_06_425581 194 1 BLUE blue JJ 10_1101-2021_01_06_425581 194 2 : : : 10_1101-2021_01_06_425581 194 3 all all DT 10_1101-2021_01_06_425581 194 4 destination destination NN 10_1101-2021_01_06_425581 194 5 cells cell NNS 10_1101-2021_01_06_425581 194 6 with with IN 10_1101-2021_01_06_425581 194 7 at at RB 10_1101-2021_01_06_425581 194 8 least least RBS 10_1101-2021_01_06_425581 194 9 one one CD 10_1101-2021_01_06_425581 194 10 edge edge NN 10_1101-2021_01_06_425581 194 11 to to IN 10_1101-2021_01_06_425581 194 12 another another DT 10_1101-2021_01_06_425581 194 13 cell cell NN 10_1101-2021_01_06_425581 194 14 . . . 10_1101-2021_01_06_425581 195 1 Red red JJ 10_1101-2021_01_06_425581 195 2 and and CC 10_1101-2021_01_06_425581 195 3 blue blue JJ 10_1101-2021_01_06_425581 195 4 are be VBP 10_1101-2021_01_06_425581 195 5 equivocal equivocal JJ 10_1101-2021_01_06_425581 195 6 . . . 10_1101-2021_01_06_425581 196 1 BLACK black NN 10_1101-2021_01_06_425581 196 2 : : : 10_1101-2021_01_06_425581 196 3 all all DT 10_1101-2021_01_06_425581 196 4 cells cell NNS 10_1101-2021_01_06_425581 196 5 with with IN 10_1101-2021_01_06_425581 196 6 more more JJR 10_1101-2021_01_06_425581 196 7 than than IN 10_1101-2021_01_06_425581 196 8 eight eight CD 10_1101-2021_01_06_425581 196 9 edges edge NNS 10_1101-2021_01_06_425581 196 10 to to IN 10_1101-2021_01_06_425581 196 11 other other JJ 10_1101-2021_01_06_425581 196 12 cells cell NNS 10_1101-2021_01_06_425581 196 13 . . . 10_1101-2021_01_06_425581 197 1 The the DT 10_1101-2021_01_06_425581 197 2 graphs graphs NN 10_1101-2021_01_06_425581 197 3 in in IN 10_1101-2021_01_06_425581 197 4 Figure Figure NNP 10_1101-2021_01_06_425581 197 5 7 7 CD 10_1101-2021_01_06_425581 197 6 tells tell VBZ 10_1101-2021_01_06_425581 197 7 us -PRON- PRP 10_1101-2021_01_06_425581 197 8 that that IN 10_1101-2021_01_06_425581 197 9 modeling model VBG 10_1101-2021_01_06_425581 197 10 division division NN 10_1101-2021_01_06_425581 197 11 events event NNS 10_1101-2021_01_06_425581 197 12 using use VBG 10_1101-2021_01_06_425581 197 13 a a DT 10_1101-2021_01_06_425581 197 14 Poisson Poisson NNP 10_1101-2021_01_06_425581 197 15 distribution distribution NN 10_1101-2021_01_06_425581 197 16 is be VBZ 10_1101-2021_01_06_425581 197 17 that that IN 10_1101-2021_01_06_425581 197 18 we -PRON- PRP 10_1101-2021_01_06_425581 197 19 can can MD 10_1101-2021_01_06_425581 197 20 achieve achieve VB 10_1101-2021_01_06_425581 197 21 the the DT 10_1101-2021_01_06_425581 197 22 same same JJ 10_1101-2021_01_06_425581 197 23 number number NN 10_1101-2021_01_06_425581 197 24 of of IN 10_1101-2021_01_06_425581 197 25 divisions division NNS 10_1101-2021_01_06_425581 197 26 as as IN 10_1101-2021_01_06_425581 197 27 fewer few JJR 10_1101-2021_01_06_425581 197 28 developmental developmental JJ 10_1101-2021_01_06_425581 197 29 time time NN 10_1101-2021_01_06_425581 197 30 units unit NNS 10_1101-2021_01_06_425581 197 31 . . . 10_1101-2021_01_06_425581 198 1 Figure figure NN 10_1101-2021_01_06_425581 198 2 7 7 CD 10_1101-2021_01_06_425581 198 3 ( ( -LRB- 10_1101-2021_01_06_425581 198 4 top top NN 10_1101-2021_01_06_425581 198 5 ) ) -RRB- 10_1101-2021_01_06_425581 198 6 shows show VBZ 10_1101-2021_01_06_425581 198 7 a a DT 10_1101-2021_01_06_425581 198 8 Uniform uniform JJ 10_1101-2021_01_06_425581 198 9 distribution distribution NN 10_1101-2021_01_06_425581 198 10 of of IN 10_1101-2021_01_06_425581 198 11 division division NN 10_1101-2021_01_06_425581 198 12 events event NNS 10_1101-2021_01_06_425581 198 13 , , , 10_1101-2021_01_06_425581 198 14 while while IN 10_1101-2021_01_06_425581 198 15 Figure figure NN 10_1101-2021_01_06_425581 198 16 7 7 CD 10_1101-2021_01_06_425581 198 17 ( ( -LRB- 10_1101-2021_01_06_425581 198 18 bottom bottom NN 10_1101-2021_01_06_425581 198 19 ) ) -RRB- 10_1101-2021_01_06_425581 198 20 shows show VBZ 10_1101-2021_01_06_425581 198 21 the the DT 10_1101-2021_01_06_425581 198 22 Uniform Uniform NNP 10_1101-2021_01_06_425581 198 23 case case NN 10_1101-2021_01_06_425581 198 24 as as IN 10_1101-2021_01_06_425581 198 25 compared compare VBN 10_1101-2021_01_06_425581 198 26 to to IN 10_1101-2021_01_06_425581 198 27 other other JJ 10_1101-2021_01_06_425581 198 28 distributions distribution NNS 10_1101-2021_01_06_425581 198 29 ( ( -LRB- 10_1101-2021_01_06_425581 198 30 Exponential Exponential NNP 10_1101-2021_01_06_425581 198 31 , , , 10_1101-2021_01_06_425581 198 32 Poisson Poisson NNP 10_1101-2021_01_06_425581 198 33 , , , 10_1101-2021_01_06_425581 198 34 and and CC 10_1101-2021_01_06_425581 198 35 Binomial Binomial NNP 10_1101-2021_01_06_425581 198 36 ) ) -RRB- 10_1101-2021_01_06_425581 198 37 . . . 10_1101-2021_01_06_425581 199 1 The the DT 10_1101-2021_01_06_425581 199 2 Poisson Poisson NNP 10_1101-2021_01_06_425581 199 3 distribution distribution NN 10_1101-2021_01_06_425581 199 4 yields yield VBZ 10_1101-2021_01_06_425581 199 5 the the DT 10_1101-2021_01_06_425581 199 6 “ " `` 10_1101-2021_01_06_425581 199 7 fastest fast JJS 10_1101-2021_01_06_425581 199 8 ” " '' 10_1101-2021_01_06_425581 199 9 time time NN 10_1101-2021_01_06_425581 199 10 relative relative JJ 10_1101-2021_01_06_425581 199 11 to to IN 10_1101-2021_01_06_425581 199 12 the the DT 10_1101-2021_01_06_425581 199 13 number number NN 10_1101-2021_01_06_425581 199 14 of of IN 10_1101-2021_01_06_425581 199 15 divisions division NNS 10_1101-2021_01_06_425581 199 16 produced produce VBN 10_1101-2021_01_06_425581 199 17 . . . 10_1101-2021_01_06_425581 200 1 By by IN 10_1101-2021_01_06_425581 200 2 contrast contrast NN 10_1101-2021_01_06_425581 200 3 , , , 10_1101-2021_01_06_425581 200 4 the the DT 10_1101-2021_01_06_425581 200 5 Binomial Binomial NNP 10_1101-2021_01_06_425581 200 6 distribution distribution NN 10_1101-2021_01_06_425581 200 7 yields yield VBZ 10_1101-2021_01_06_425581 200 8 the the DT 10_1101-2021_01_06_425581 200 9 lowest low JJS 10_1101-2021_01_06_425581 200 10 number number NN 10_1101-2021_01_06_425581 200 11 of of IN 10_1101-2021_01_06_425581 200 12 divisions division NNS 10_1101-2021_01_06_425581 200 13 ( ( -LRB- 10_1101-2021_01_06_425581 200 14 hence hence RB 10_1101-2021_01_06_425581 200 15 is be VBZ 10_1101-2021_01_06_425581 200 16 the the DT 10_1101-2021_01_06_425581 200 17 slowest slow JJS 10_1101-2021_01_06_425581 200 18 method method NN 10_1101-2021_01_06_425581 200 19 examined examine VBN 10_1101-2021_01_06_425581 200 20 ) ) -RRB- 10_1101-2021_01_06_425581 200 21 . . . 10_1101-2021_01_06_425581 201 1 However however RB 10_1101-2021_01_06_425581 201 2 , , , 10_1101-2021_01_06_425581 201 3 none none NN 10_1101-2021_01_06_425581 201 4 of of IN 10_1101-2021_01_06_425581 201 5 these these DT 10_1101-2021_01_06_425581 201 6 methods method NNS 10_1101-2021_01_06_425581 201 7 produce produce VBP 10_1101-2021_01_06_425581 201 8 orders order NNS 10_1101-2021_01_06_425581 201 9 - - HYPH 10_1101-2021_01_06_425581 201 10 of of IN 10_1101-2021_01_06_425581 201 11 - - HYPH 10_1101-2021_01_06_425581 201 12 magnitude magnitude NN 10_1101-2021_01_06_425581 201 13 differences difference NNS 10_1101-2021_01_06_425581 201 14 in in IN 10_1101-2021_01_06_425581 201 15 division division NN 10_1101-2021_01_06_425581 201 16 rate rate NN 10_1101-2021_01_06_425581 201 17 , , , 10_1101-2021_01_06_425581 201 18 which which WDT 10_1101-2021_01_06_425581 201 19 is be VBZ 10_1101-2021_01_06_425581 201 20 what what WP 10_1101-2021_01_06_425581 201 21 would would MD 10_1101-2021_01_06_425581 201 22 be be VB 10_1101-2021_01_06_425581 201 23 expected expect VBN 10_1101-2021_01_06_425581 201 24 from from IN 10_1101-2021_01_06_425581 201 25 a a DT 10_1101-2021_01_06_425581 201 26 bursty bursty JJ 10_1101-2021_01_06_425581 201 27 signature signature NN 10_1101-2021_01_06_425581 201 28 . . . 10_1101-2021_01_06_425581 202 1 Discussion discussion NN 10_1101-2021_01_06_425581 202 2 In in IN 10_1101-2021_01_06_425581 202 3 this this DT 10_1101-2021_01_06_425581 202 4 paper paper NN 10_1101-2021_01_06_425581 202 5 , , , 10_1101-2021_01_06_425581 202 6 we -PRON- PRP 10_1101-2021_01_06_425581 202 7 examine examine VBP 10_1101-2021_01_06_425581 202 8 the the DT 10_1101-2021_01_06_425581 202 9 periodicity periodicity NN 10_1101-2021_01_06_425581 202 10 of of IN 10_1101-2021_01_06_425581 202 11 cell cell NN 10_1101-2021_01_06_425581 202 12 proliferation proliferation NN 10_1101-2021_01_06_425581 202 13 and and CC 10_1101-2021_01_06_425581 202 14 division division NN 10_1101-2021_01_06_425581 202 15 examined examine VBD 10_1101-2021_01_06_425581 202 16 using use VBG 10_1101-2021_01_06_425581 202 17 three three CD 10_1101-2021_01_06_425581 202 18 model model NN 10_1101-2021_01_06_425581 202 19 systems system NNS 10_1101-2021_01_06_425581 202 20 : : : 10_1101-2021_01_06_425581 202 21 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 202 22 ( ( -LRB- 10_1101-2021_01_06_425581 202 23 ​Danio ​Danio NNP 10_1101-2021_01_06_425581 202 24 rerio rerio NN 10_1101-2021_01_06_425581 202 25 ​ ​ NNP 10_1101-2021_01_06_425581 202 26 ) ) -RRB- 10_1101-2021_01_06_425581 202 27 , , , 10_1101-2021_01_06_425581 202 28 Nematode Nematode NNP 10_1101-2021_01_06_425581 202 29 ( ( -LRB- 10_1101-2021_01_06_425581 202 30 ​Caenorhabditis ​caenorhabditis JJ 10_1101-2021_01_06_425581 202 31 elegans elegan NNS 10_1101-2021_01_06_425581 202 32 ​ ​ NNP 10_1101-2021_01_06_425581 202 33 ) ) -RRB- 10_1101-2021_01_06_425581 202 34 , , , 10_1101-2021_01_06_425581 202 35 and and CC 10_1101-2021_01_06_425581 202 36 a a DT 10_1101-2021_01_06_425581 202 37 simulated simulate VBN 10_1101-2021_01_06_425581 202 38 embryo embryo NN 10_1101-2021_01_06_425581 202 39 . . . 10_1101-2021_01_06_425581 203 1 When when WRB 10_1101-2021_01_06_425581 203 2 we -PRON- PRP 10_1101-2021_01_06_425581 203 3 refer refer VBP 10_1101-2021_01_06_425581 203 4 to to IN 10_1101-2021_01_06_425581 203 5 periodicity periodicity NN 10_1101-2021_01_06_425581 203 6 in in IN 10_1101-2021_01_06_425581 203 7 development development NN 10_1101-2021_01_06_425581 203 8 , , , 10_1101-2021_01_06_425581 203 9 we -PRON- PRP 10_1101-2021_01_06_425581 203 10 mean mean VBP 10_1101-2021_01_06_425581 203 11 events event NNS 10_1101-2021_01_06_425581 203 12 that that WDT 10_1101-2021_01_06_425581 203 13 reoccur reoccur VBP 10_1101-2021_01_06_425581 203 14 over over IN 10_1101-2021_01_06_425581 203 15 time time NN 10_1101-2021_01_06_425581 203 16 . . . 10_1101-2021_01_06_425581 204 1 Regular regular JJ 10_1101-2021_01_06_425581 204 2 pulses pulse NNS 10_1101-2021_01_06_425581 204 3 of of IN 10_1101-2021_01_06_425581 204 4 cell cell NN 10_1101-2021_01_06_425581 204 5 proliferation proliferation NN 10_1101-2021_01_06_425581 204 6 events event NNS 10_1101-2021_01_06_425581 204 7 in in IN 10_1101-2021_01_06_425581 204 8 a a DT 10_1101-2021_01_06_425581 204 9 short short JJ 10_1101-2021_01_06_425581 204 10 period period NN 10_1101-2021_01_06_425581 204 11 of of IN 10_1101-2021_01_06_425581 204 12 time time NN 10_1101-2021_01_06_425581 204 13 . . . 10_1101-2021_01_06_425581 205 1 This this DT 10_1101-2021_01_06_425581 205 2 leads lead VBZ 10_1101-2021_01_06_425581 205 3 us -PRON- PRP 10_1101-2021_01_06_425581 205 4 to to TO 10_1101-2021_01_06_425581 205 5 propose propose VB 10_1101-2021_01_06_425581 205 6 a a DT 10_1101-2021_01_06_425581 205 7 principle principle NN 10_1101-2021_01_06_425581 205 8 of of IN 10_1101-2021_01_06_425581 205 9 development development NN 10_1101-2021_01_06_425581 205 10 based base VBN 10_1101-2021_01_06_425581 205 11 on on IN 10_1101-2021_01_06_425581 205 12 timing timing NN 10_1101-2021_01_06_425581 205 13 . . . 10_1101-2021_01_06_425581 206 1 There there EX 10_1101-2021_01_06_425581 206 2 can can MD 10_1101-2021_01_06_425581 206 3 also also RB 10_1101-2021_01_06_425581 206 4 be be VB 10_1101-2021_01_06_425581 206 5 a a DT 10_1101-2021_01_06_425581 206 6 spatial spatial JJ 10_1101-2021_01_06_425581 206 7 component component NN 10_1101-2021_01_06_425581 206 8 of of IN 10_1101-2021_01_06_425581 206 9 developmental developmental JJ 10_1101-2021_01_06_425581 206 10 periodicity periodicity NN 10_1101-2021_01_06_425581 206 11 as as RB 10_1101-2021_01_06_425581 206 12 well well RB 10_1101-2021_01_06_425581 206 13 . . . 10_1101-2021_01_06_425581 207 1 These these DT 10_1101-2021_01_06_425581 207 2 include include VBP 10_1101-2021_01_06_425581 207 3 signatures signature NNS 10_1101-2021_01_06_425581 207 4 of of IN 10_1101-2021_01_06_425581 207 5 time time NN 10_1101-2021_01_06_425581 207 6 - - HYPH 10_1101-2021_01_06_425581 207 7 independent independent JJ 10_1101-2021_01_06_425581 207 8 spatial spatial JJ 10_1101-2021_01_06_425581 207 9 periodicity periodicity NN 10_1101-2021_01_06_425581 207 10 such such JJ 10_1101-2021_01_06_425581 207 11 as as IN 10_1101-2021_01_06_425581 207 12 tilings tiling NNS 10_1101-2021_01_06_425581 207 13 and and CC 10_1101-2021_01_06_425581 207 14 other other JJ 10_1101-2021_01_06_425581 207 15 repeatable repeatable JJ 10_1101-2021_01_06_425581 207 16 patterns pattern NNS 10_1101-2021_01_06_425581 207 17 across across IN 10_1101-2021_01_06_425581 207 18 space space NN 10_1101-2021_01_06_425581 207 19 . . . 10_1101-2021_01_06_425581 208 1 Interpretation interpretation NN 10_1101-2021_01_06_425581 208 2 of of IN 10_1101-2021_01_06_425581 208 3 Figures figure NNS 10_1101-2021_01_06_425581 208 4 We -PRON- PRP 10_1101-2021_01_06_425581 208 5 interpret interpret VBP 10_1101-2021_01_06_425581 208 6 Figures figure NNS 10_1101-2021_01_06_425581 208 7 1 1 CD 10_1101-2021_01_06_425581 208 8 and and CC 10_1101-2021_01_06_425581 208 9 3 3 CD 10_1101-2021_01_06_425581 208 10 in in IN 10_1101-2021_01_06_425581 208 11 a a DT 10_1101-2021_01_06_425581 208 12 number number NN 10_1101-2021_01_06_425581 208 13 of of IN 10_1101-2021_01_06_425581 208 14 ways way NNS 10_1101-2021_01_06_425581 208 15 . . . 10_1101-2021_01_06_425581 209 1 The the DT 10_1101-2021_01_06_425581 209 2 first first JJ 10_1101-2021_01_06_425581 209 3 is be VBZ 10_1101-2021_01_06_425581 209 4 by by IN 10_1101-2021_01_06_425581 209 5 looking look VBG 10_1101-2021_01_06_425581 209 6 at at IN 10_1101-2021_01_06_425581 209 7 components component NNS 10_1101-2021_01_06_425581 209 8 of of IN 10_1101-2021_01_06_425581 209 9 variation variation NN 10_1101-2021_01_06_425581 209 10 over over IN 10_1101-2021_01_06_425581 209 11 time time NN 10_1101-2021_01_06_425581 209 12 . . . 10_1101-2021_01_06_425581 210 1 We -PRON- PRP 10_1101-2021_01_06_425581 210 2 measure measure VBP 10_1101-2021_01_06_425581 210 3 this this DT 10_1101-2021_01_06_425581 210 4 in in IN 10_1101-2021_01_06_425581 210 5 terms term NNS 10_1101-2021_01_06_425581 210 6 of of IN 10_1101-2021_01_06_425581 210 7 the the DT 10_1101-2021_01_06_425581 210 8 interval interval NN 10_1101-2021_01_06_425581 210 9 between between IN 10_1101-2021_01_06_425581 210 10 cell cell NN 10_1101-2021_01_06_425581 210 11 birth birth NN 10_1101-2021_01_06_425581 210 12 times time NNS 10_1101-2021_01_06_425581 210 13 in in IN 10_1101-2021_01_06_425581 210 14 ​C. ​C. NNP 10_1101-2021_01_06_425581 211 1 elegans elegans NNP 10_1101-2021_01_06_425581 211 2 ( ( -LRB- 10_1101-2021_01_06_425581 211 3 Figure Figure NNP 10_1101-2021_01_06_425581 211 4 2 2 CD 10_1101-2021_01_06_425581 211 5 ) ) -RRB- 10_1101-2021_01_06_425581 211 6 and and CC 10_1101-2021_01_06_425581 211 7 the the DT 10_1101-2021_01_06_425581 211 8 frequency frequency NN 10_1101-2021_01_06_425581 211 9 of of IN 10_1101-2021_01_06_425581 211 10 cell cell NN 10_1101-2021_01_06_425581 211 11 birth birth NN 10_1101-2021_01_06_425581 211 12 rates rate NNS 10_1101-2021_01_06_425581 211 13 in in IN 10_1101-2021_01_06_425581 211 14 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 211 15 ( ( -LRB- 10_1101-2021_01_06_425581 211 16 Figure Figure NNP 10_1101-2021_01_06_425581 211 17 4 4 CD 10_1101-2021_01_06_425581 211 18 ) ) -RRB- 10_1101-2021_01_06_425581 211 19 . . . 10_1101-2021_01_06_425581 212 1 We -PRON- PRP 10_1101-2021_01_06_425581 212 2 also also RB 10_1101-2021_01_06_425581 212 3 focus focus VBP 10_1101-2021_01_06_425581 212 4 on on IN 10_1101-2021_01_06_425581 212 5 intervals interval NNS 10_1101-2021_01_06_425581 212 6 between between IN 10_1101-2021_01_06_425581 212 7 other other JJ 10_1101-2021_01_06_425581 212 8 features feature NNS 10_1101-2021_01_06_425581 212 9 in in IN 10_1101-2021_01_06_425581 212 10 the the DT 10_1101-2021_01_06_425581 212 11 time time NN 10_1101-2021_01_06_425581 212 12 - - HYPH 10_1101-2021_01_06_425581 212 13 series series NN 10_1101-2021_01_06_425581 212 14 such such JJ 10_1101-2021_01_06_425581 212 15 as as IN 10_1101-2021_01_06_425581 212 16 peaks peak NNS 10_1101-2021_01_06_425581 212 17 for for IN 10_1101-2021_01_06_425581 212 18 both both DT 10_1101-2021_01_06_425581 212 19 species specie NNS 10_1101-2021_01_06_425581 212 20 in in IN 10_1101-2021_01_06_425581 212 21 Figure Figure NNP 10_1101-2021_01_06_425581 212 22 5 5 CD 10_1101-2021_01_06_425581 212 23 . . . 10_1101-2021_01_06_425581 213 1 In in IN 10_1101-2021_01_06_425581 213 2 investigating investigate VBG 10_1101-2021_01_06_425581 213 3 peak peak NN 10_1101-2021_01_06_425581 213 4 intervals interval NNS 10_1101-2021_01_06_425581 213 5 , , , 10_1101-2021_01_06_425581 213 6 we -PRON- PRP 10_1101-2021_01_06_425581 213 7 discover discover VBP 10_1101-2021_01_06_425581 213 8 a a DT 10_1101-2021_01_06_425581 213 9 similar similar JJ 10_1101-2021_01_06_425581 213 10 distribution distribution NN 10_1101-2021_01_06_425581 213 11 of of IN 10_1101-2021_01_06_425581 213 12 cell cell NN 10_1101-2021_01_06_425581 213 13 division division NN 10_1101-2021_01_06_425581 213 14 events event NNS 10_1101-2021_01_06_425581 213 15 between between IN 10_1101-2021_01_06_425581 213 16 species specie NNS 10_1101-2021_01_06_425581 213 17 in in IN 10_1101-2021_01_06_425581 213 18 Figures Figures NNP 10_1101-2021_01_06_425581 213 19 2 2 CD 10_1101-2021_01_06_425581 213 20 and and CC 10_1101-2021_01_06_425581 213 21 4 4 CD 10_1101-2021_01_06_425581 213 22 , , , 10_1101-2021_01_06_425581 213 23 but but CC 10_1101-2021_01_06_425581 213 24 a a DT 10_1101-2021_01_06_425581 213 25 difference difference NN 10_1101-2021_01_06_425581 213 26 between between IN 10_1101-2021_01_06_425581 213 27 species specie NNS 10_1101-2021_01_06_425581 213 28 when when WRB 10_1101-2021_01_06_425581 213 29 looking look VBG 10_1101-2021_01_06_425581 213 30 at at IN 10_1101-2021_01_06_425581 213 31 specific specific JJ 10_1101-2021_01_06_425581 213 32 time time NN 10_1101-2021_01_06_425581 213 33 - - HYPH 10_1101-2021_01_06_425581 213 34 series series NN 10_1101-2021_01_06_425581 213 35 features feature NNS 10_1101-2021_01_06_425581 213 36 ( ( -LRB- 10_1101-2021_01_06_425581 213 37 Figure Figure NNP 10_1101-2021_01_06_425581 213 38 5 5 CD 10_1101-2021_01_06_425581 213 39 ) ) -RRB- 10_1101-2021_01_06_425581 213 40 . . . 10_1101-2021_01_06_425581 214 1 The the DT 10_1101-2021_01_06_425581 214 2 reason reason NN 10_1101-2021_01_06_425581 214 3 for for IN 10_1101-2021_01_06_425581 214 4 this this DT 10_1101-2021_01_06_425581 214 5 is be VBZ 10_1101-2021_01_06_425581 214 6 clear clear JJ 10_1101-2021_01_06_425581 214 7 : : : 10_1101-2021_01_06_425581 214 8 features feature NNS 10_1101-2021_01_06_425581 214 9 such such JJ 10_1101-2021_01_06_425581 214 10 as as IN 10_1101-2021_01_06_425581 214 11 peaks peak NNS 10_1101-2021_01_06_425581 214 12 ( ( -LRB- 10_1101-2021_01_06_425581 214 13 magnitude magnitude NN 10_1101-2021_01_06_425581 214 14 ) ) -RRB- 10_1101-2021_01_06_425581 214 15 have have VBP 10_1101-2021_01_06_425581 214 16 a a DT 10_1101-2021_01_06_425581 214 17 different different JJ 10_1101-2021_01_06_425581 214 18 underlying underlying JJ 10_1101-2021_01_06_425581 214 19 mechanism mechanism NN 10_1101-2021_01_06_425581 214 20 than than IN 10_1101-2021_01_06_425581 214 21 events event NNS 10_1101-2021_01_06_425581 214 22 such such JJ 10_1101-2021_01_06_425581 214 23 as as IN 10_1101-2021_01_06_425581 214 24 cell cell NN 10_1101-2021_01_06_425581 214 25 division division NN 10_1101-2021_01_06_425581 214 26 . . . 10_1101-2021_01_06_425581 215 1 While while IN 10_1101-2021_01_06_425581 215 2 both both DT 10_1101-2021_01_06_425581 215 3 are be VBP 10_1101-2021_01_06_425581 215 4 linked link VBN 10_1101-2021_01_06_425581 215 5 to to IN 10_1101-2021_01_06_425581 215 6 the the DT 10_1101-2021_01_06_425581 215 7 lineage lineage NN 10_1101-2021_01_06_425581 215 8 tree tree NN 10_1101-2021_01_06_425581 215 9 , , , 10_1101-2021_01_06_425581 215 10 magnitude magnitude NN 10_1101-2021_01_06_425581 215 11 differences difference NNS 10_1101-2021_01_06_425581 215 12 are be VBP 10_1101-2021_01_06_425581 215 13 linked link VBN 10_1101-2021_01_06_425581 215 14 to to IN 10_1101-2021_01_06_425581 215 15 the the DT 10_1101-2021_01_06_425581 215 16 synchronization synchronization NN 10_1101-2021_01_06_425581 215 17 of of IN 10_1101-2021_01_06_425581 215 18 cell cell NN 10_1101-2021_01_06_425581 215 19 division division NN 10_1101-2021_01_06_425581 215 20 due due JJ 10_1101-2021_01_06_425581 215 21 to to IN 10_1101-2021_01_06_425581 215 22 deterministic deterministic JJ 10_1101-2021_01_06_425581 215 23 timing timing NN 10_1101-2021_01_06_425581 215 24 . . . 10_1101-2021_01_06_425581 216 1 With with IN 10_1101-2021_01_06_425581 216 2 deterministic deterministic JJ 10_1101-2021_01_06_425581 216 3 timing timing NN 10_1101-2021_01_06_425581 216 4 , , , 10_1101-2021_01_06_425581 216 5 synchronized synchronize VBN 10_1101-2021_01_06_425581 216 6 cell cell NN 10_1101-2021_01_06_425581 216 7 divisions division NNS 10_1101-2021_01_06_425581 216 8 produce produce VBP 10_1101-2021_01_06_425581 216 9 a a DT 10_1101-2021_01_06_425581 216 10 lot lot NN 10_1101-2021_01_06_425581 216 11 of of IN 10_1101-2021_01_06_425581 216 12 cells cell NNS 10_1101-2021_01_06_425581 216 13 at at IN 10_1101-2021_01_06_425581 216 14 any any DT 10_1101-2021_01_06_425581 216 15 one one CD 10_1101-2021_01_06_425581 216 16 point point NN 10_1101-2021_01_06_425581 216 17 in in IN 10_1101-2021_01_06_425581 216 18 developmental developmental JJ 10_1101-2021_01_06_425581 216 19 time time NN 10_1101-2021_01_06_425581 216 20 , , , 10_1101-2021_01_06_425581 216 21 but but CC 10_1101-2021_01_06_425581 216 22 little little JJ 10_1101-2021_01_06_425581 216 23 fluctuation fluctuation NN 10_1101-2021_01_06_425581 216 24 between between IN 10_1101-2021_01_06_425581 216 25 time time NN 10_1101-2021_01_06_425581 216 26 points point NNS 10_1101-2021_01_06_425581 216 27 . . . 10_1101-2021_01_06_425581 217 1 In in IN 10_1101-2021_01_06_425581 217 2 the the DT 10_1101-2021_01_06_425581 217 3 case case NN 10_1101-2021_01_06_425581 217 4 of of IN 10_1101-2021_01_06_425581 217 5 stochastic stochastic JJ 10_1101-2021_01_06_425581 217 6 timing timing NN 10_1101-2021_01_06_425581 217 7 , , , 10_1101-2021_01_06_425581 217 8 a a DT 10_1101-2021_01_06_425581 217 9 lot lot NN 10_1101-2021_01_06_425581 217 10 of of IN 10_1101-2021_01_06_425581 217 11 cells cell NNS 10_1101-2021_01_06_425581 217 12 can can MD 10_1101-2021_01_06_425581 217 13 be be VB 10_1101-2021_01_06_425581 217 14 produced produce VBN 10_1101-2021_01_06_425581 217 15 with with IN 10_1101-2021_01_06_425581 217 16 a a DT 10_1101-2021_01_06_425581 217 17 great great JJ 10_1101-2021_01_06_425581 217 18 degree degree NN 10_1101-2021_01_06_425581 217 19 of of IN 10_1101-2021_01_06_425581 217 20 fluctuation fluctuation NN 10_1101-2021_01_06_425581 217 21 between between IN 10_1101-2021_01_06_425581 217 22 time time NN 10_1101-2021_01_06_425581 217 23 points point NNS 10_1101-2021_01_06_425581 217 24 . . . 10_1101-2021_01_06_425581 218 1 There there EX 10_1101-2021_01_06_425581 218 2 are be VBP 10_1101-2021_01_06_425581 218 3 a a DT 10_1101-2021_01_06_425581 218 4 number number NN 10_1101-2021_01_06_425581 218 5 of of IN 10_1101-2021_01_06_425581 218 6 ways way NNS 10_1101-2021_01_06_425581 218 7 to to TO 10_1101-2021_01_06_425581 218 8 interpret interpret VB 10_1101-2021_01_06_425581 218 9 the the DT 10_1101-2021_01_06_425581 218 10 embryo embryo NN 10_1101-2021_01_06_425581 218 11 network network NN 10_1101-2021_01_06_425581 218 12 and and CC 10_1101-2021_01_06_425581 218 13 3-D 3-d CD 10_1101-2021_01_06_425581 218 14 plot plot NN 10_1101-2021_01_06_425581 218 15 shown show VBN 10_1101-2021_01_06_425581 218 16 in in IN 10_1101-2021_01_06_425581 218 17 Figure Figure NNP 10_1101-2021_01_06_425581 218 18 6 6 CD 10_1101-2021_01_06_425581 218 19 . . . 10_1101-2021_01_06_425581 219 1 One one CD 10_1101-2021_01_06_425581 219 2 interpretation interpretation NN 10_1101-2021_01_06_425581 219 3 is be VBZ 10_1101-2021_01_06_425581 219 4 that that IN 10_1101-2021_01_06_425581 219 5 in in IN 10_1101-2021_01_06_425581 219 6 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 219 7 , , , 10_1101-2021_01_06_425581 219 8 the the DT 10_1101-2021_01_06_425581 219 9 phenotype phenotype NN 10_1101-2021_01_06_425581 219 10 is be VBZ 10_1101-2021_01_06_425581 219 11 built build VBN 10_1101-2021_01_06_425581 219 12 from from IN 10_1101-2021_01_06_425581 219 13 the the DT 10_1101-2021_01_06_425581 219 14 inside inside NN 10_1101-2021_01_06_425581 219 15 out out RB 10_1101-2021_01_06_425581 219 16 , , , 10_1101-2021_01_06_425581 219 17 with with IN 10_1101-2021_01_06_425581 219 18 densely densely RB 10_1101-2021_01_06_425581 219 19 - - HYPH 10_1101-2021_01_06_425581 219 20 packed pack VBN 10_1101-2021_01_06_425581 219 21 cells cell NNS 10_1101-2021_01_06_425581 219 22 representing represent VBG 10_1101-2021_01_06_425581 219 23 fledgling fledgling NN 10_1101-2021_01_06_425581 219 24 anatomical anatomical JJ 10_1101-2021_01_06_425581 219 25 structures structure NNS 10_1101-2021_01_06_425581 219 26 such such JJ 10_1101-2021_01_06_425581 219 27 as as IN 10_1101-2021_01_06_425581 219 28 the the DT 10_1101-2021_01_06_425581 219 29 notochord notochord NN 10_1101-2021_01_06_425581 219 30 and and CC 10_1101-2021_01_06_425581 219 31 heart heart NN 10_1101-2021_01_06_425581 219 32 . . . 10_1101-2021_01_06_425581 220 1 These these DT 10_1101-2021_01_06_425581 220 2 clusters cluster NNS 10_1101-2021_01_06_425581 220 3 may may MD 10_1101-2021_01_06_425581 220 4 be be VB 10_1101-2021_01_06_425581 220 5 linked link VBN 10_1101-2021_01_06_425581 220 6 to to IN 10_1101-2021_01_06_425581 220 7 rounds round NNS 10_1101-2021_01_06_425581 220 8 of of IN 10_1101-2021_01_06_425581 220 9 cell cell NN 10_1101-2021_01_06_425581 220 10 division division NN 10_1101-2021_01_06_425581 220 11 ( ( -LRB- 10_1101-2021_01_06_425581 220 12 occuring occur VBG 10_1101-2021_01_06_425581 220 13 in in IN 10_1101-2021_01_06_425581 220 14 temporal temporal JJ 10_1101-2021_01_06_425581 220 15 bursts burst NNS 10_1101-2021_01_06_425581 220 16 ) ) -RRB- 10_1101-2021_01_06_425581 220 17 , , , 10_1101-2021_01_06_425581 220 18 while while IN 10_1101-2021_01_06_425581 220 19 cell cell NN 10_1101-2021_01_06_425581 220 20 divisions division NNS 10_1101-2021_01_06_425581 220 21 occurring occur VBG 10_1101-2021_01_06_425581 220 22 during during IN 10_1101-2021_01_06_425581 220 23 the the DT 10_1101-2021_01_06_425581 220 24 inter inter JJ 10_1101-2021_01_06_425581 220 25 - - JJ 10_1101-2021_01_06_425581 220 26 burst burst VBN 10_1101-2021_01_06_425581 220 27 intervals interval NNS 10_1101-2021_01_06_425581 220 28 may may MD 10_1101-2021_01_06_425581 220 29 contribute contribute VB 10_1101-2021_01_06_425581 220 30 to to IN 10_1101-2021_01_06_425581 220 31 cells cell NNS 10_1101-2021_01_06_425581 220 32 at at IN 10_1101-2021_01_06_425581 220 33 the the DT 10_1101-2021_01_06_425581 220 34 outer outer JJ 10_1101-2021_01_06_425581 220 35 edge edge NN 10_1101-2021_01_06_425581 220 36 of of IN 10_1101-2021_01_06_425581 220 37 the the DT 10_1101-2021_01_06_425581 220 38 embryo embryo NN 10_1101-2021_01_06_425581 220 39 and and CC 10_1101-2021_01_06_425581 220 40 perhaps perhaps RB 10_1101-2021_01_06_425581 220 41 representing represent VBG 10_1101-2021_01_06_425581 220 42 the the DT 10_1101-2021_01_06_425581 220 43 ectoderm ectoderm NN 10_1101-2021_01_06_425581 220 44 layer layer NN 10_1101-2021_01_06_425581 220 45 [ [ -LRB- 10_1101-2021_01_06_425581 220 46 20 20 CD 10_1101-2021_01_06_425581 220 47 , , , 10_1101-2021_01_06_425581 220 48 21 21 CD 10_1101-2021_01_06_425581 220 49 ] ] -RRB- 10_1101-2021_01_06_425581 220 50 . . . 10_1101-2021_01_06_425581 221 1 In in IN 10_1101-2021_01_06_425581 221 2 this this DT 10_1101-2021_01_06_425581 221 3 way way NN 10_1101-2021_01_06_425581 221 4 , , , 10_1101-2021_01_06_425581 221 5 temporal temporal JJ 10_1101-2021_01_06_425581 221 6 bursts burst NNS 10_1101-2021_01_06_425581 221 7 of of IN 10_1101-2021_01_06_425581 221 8 cell cell NN 10_1101-2021_01_06_425581 221 9 division division NN 10_1101-2021_01_06_425581 221 10 lead lead VBP 10_1101-2021_01_06_425581 221 11 to to IN 10_1101-2021_01_06_425581 221 12 a a DT 10_1101-2021_01_06_425581 221 13 spatial spatial JJ 10_1101-2021_01_06_425581 221 14 hierarchy hierarchy NN 10_1101-2021_01_06_425581 221 15 of of IN 10_1101-2021_01_06_425581 221 16 cell cell NN 10_1101-2021_01_06_425581 221 17 differentiation differentiation NN 10_1101-2021_01_06_425581 221 18 . . . 10_1101-2021_01_06_425581 222 1 10 10 CD 10_1101-2021_01_06_425581 222 2 .CC .CC : 10_1101-2021_01_06_425581 222 3 - - HYPH 10_1101-2021_01_06_425581 222 4 BY BY NNP 10_1101-2021_01_06_425581 222 5 - - HYPH 10_1101-2021_01_06_425581 222 6 NC NC NNP 10_1101-2021_01_06_425581 222 7 4.0 4.0 CD 10_1101-2021_01_06_425581 222 8 International international JJ 10_1101-2021_01_06_425581 222 9 licensemade licensemade NN 10_1101-2021_01_06_425581 222 10 available available JJ 10_1101-2021_01_06_425581 222 11 under under IN 10_1101-2021_01_06_425581 222 12 a a DT 10_1101-2021_01_06_425581 222 13 ( ( -LRB- 10_1101-2021_01_06_425581 222 14 which which WDT 10_1101-2021_01_06_425581 222 15 was be VBD 10_1101-2021_01_06_425581 222 16 not not RB 10_1101-2021_01_06_425581 222 17 certified certify VBN 10_1101-2021_01_06_425581 222 18 by by IN 10_1101-2021_01_06_425581 222 19 peer peer NN 10_1101-2021_01_06_425581 222 20 review review NN 10_1101-2021_01_06_425581 222 21 ) ) -RRB- 10_1101-2021_01_06_425581 222 22 is be VBZ 10_1101-2021_01_06_425581 222 23 the the DT 10_1101-2021_01_06_425581 222 24 author author NN 10_1101-2021_01_06_425581 222 25 / / SYM 10_1101-2021_01_06_425581 222 26 funder funder NN 10_1101-2021_01_06_425581 222 27 , , , 10_1101-2021_01_06_425581 222 28 who who WP 10_1101-2021_01_06_425581 222 29 has have VBZ 10_1101-2021_01_06_425581 222 30 granted grant VBN 10_1101-2021_01_06_425581 222 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 222 32 a a DT 10_1101-2021_01_06_425581 222 33 license license NN 10_1101-2021_01_06_425581 222 34 to to TO 10_1101-2021_01_06_425581 222 35 display display VB 10_1101-2021_01_06_425581 222 36 the the DT 10_1101-2021_01_06_425581 222 37 preprint preprint NN 10_1101-2021_01_06_425581 222 38 in in IN 10_1101-2021_01_06_425581 222 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 222 40 . . . 10_1101-2021_01_06_425581 223 1 It -PRON- PRP 10_1101-2021_01_06_425581 223 2 is be VBZ 10_1101-2021_01_06_425581 223 3 The the DT 10_1101-2021_01_06_425581 223 4 copyright copyright NN 10_1101-2021_01_06_425581 223 5 holder holder NN 10_1101-2021_01_06_425581 223 6 for for IN 10_1101-2021_01_06_425581 223 7 this this DT 10_1101-2021_01_06_425581 223 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 223 9 version version NN 10_1101-2021_01_06_425581 223 10 posted post VBD 10_1101-2021_01_06_425581 223 11 January January NNP 10_1101-2021_01_06_425581 223 12 8 8 CD 10_1101-2021_01_06_425581 223 13 , , , 10_1101-2021_01_06_425581 223 14 2021 2021 CD 10_1101-2021_01_06_425581 223 15 . . . 10_1101-2021_01_06_425581 223 16 ; ; : 10_1101-2021_01_06_425581 223 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 223 18 : : : 10_1101-2021_01_06_425581 223 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 223 20 preprint preprint NN 10_1101-2021_01_06_425581 223 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 223 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 223 23 Figure Figure NNP 10_1101-2021_01_06_425581 223 24 7 7 CD 10_1101-2021_01_06_425581 223 25 . . . 10_1101-2021_01_06_425581 224 1 Comparison comparison NN 10_1101-2021_01_06_425581 224 2 of of IN 10_1101-2021_01_06_425581 224 3 cumulative cumulative JJ 10_1101-2021_01_06_425581 224 4 cell cell NN 10_1101-2021_01_06_425581 224 5 division division NN 10_1101-2021_01_06_425581 224 6 events event NNS 10_1101-2021_01_06_425581 224 7 and and CC 10_1101-2021_01_06_425581 224 8 the the DT 10_1101-2021_01_06_425581 224 9 speed speed NN 10_1101-2021_01_06_425581 224 10 of of IN 10_1101-2021_01_06_425581 224 11 division division NN 10_1101-2021_01_06_425581 224 12 generated generate VBN 10_1101-2021_01_06_425581 224 13 by by IN 10_1101-2021_01_06_425581 224 14 a a DT 10_1101-2021_01_06_425581 224 15 numeric numeric JJ 10_1101-2021_01_06_425581 224 16 embryo embryo NN 10_1101-2021_01_06_425581 224 17 . . . 10_1101-2021_01_06_425581 225 1 Top top JJ 10_1101-2021_01_06_425581 225 2 : : : 10_1101-2021_01_06_425581 225 3 Uniform Uniform NNP 10_1101-2021_01_06_425581 225 4 only only RB 10_1101-2021_01_06_425581 225 5 ( ( -LRB- 10_1101-2021_01_06_425581 225 6 blue blue NNP 10_1101-2021_01_06_425581 225 7 ) ) -RRB- 10_1101-2021_01_06_425581 225 8 . . . 10_1101-2021_01_06_425581 226 1 Bottom bottom NN 10_1101-2021_01_06_425581 226 2 : : : 10_1101-2021_01_06_425581 226 3 Uniform Uniform NNP 10_1101-2021_01_06_425581 226 4 ( ( -LRB- 10_1101-2021_01_06_425581 226 5 blue blue NNP 10_1101-2021_01_06_425581 226 6 ) ) -RRB- 10_1101-2021_01_06_425581 226 7 , , , 10_1101-2021_01_06_425581 226 8 Exponential Exponential NNP 10_1101-2021_01_06_425581 226 9 ( ( -LRB- 10_1101-2021_01_06_425581 226 10 orange orange NNP 10_1101-2021_01_06_425581 226 11 ) ) -RRB- 10_1101-2021_01_06_425581 226 12 , , , 10_1101-2021_01_06_425581 226 13 Poisson Poisson NNP 10_1101-2021_01_06_425581 226 14 ( ( -LRB- 10_1101-2021_01_06_425581 226 15 gray gray NNP 10_1101-2021_01_06_425581 226 16 ) ) -RRB- 10_1101-2021_01_06_425581 226 17 , , , 10_1101-2021_01_06_425581 226 18 and and CC 10_1101-2021_01_06_425581 226 19 Binomial Binomial NNP 10_1101-2021_01_06_425581 226 20 ( ( -LRB- 10_1101-2021_01_06_425581 226 21 yellow yellow NN 10_1101-2021_01_06_425581 226 22 ) ) -RRB- 10_1101-2021_01_06_425581 226 23 . . . 10_1101-2021_01_06_425581 227 1 This this DT 10_1101-2021_01_06_425581 227 2 spatial spatial JJ 10_1101-2021_01_06_425581 227 3 hierarchy hierarchy NN 10_1101-2021_01_06_425581 227 4 involves involve VBZ 10_1101-2021_01_06_425581 227 5 a a DT 10_1101-2021_01_06_425581 227 6 number number NN 10_1101-2021_01_06_425581 227 7 of of IN 10_1101-2021_01_06_425581 227 8 evolutionary evolutionary JJ 10_1101-2021_01_06_425581 227 9 and and CC 10_1101-2021_01_06_425581 227 10 biophysical biophysical JJ 10_1101-2021_01_06_425581 227 11 constraints constraint NNS 10_1101-2021_01_06_425581 227 12 that that WDT 10_1101-2021_01_06_425581 227 13 have have VBP 10_1101-2021_01_06_425581 227 14 been be VBN 10_1101-2021_01_06_425581 227 15 demonstrated demonstrate VBN 10_1101-2021_01_06_425581 227 16 in in IN 10_1101-2021_01_06_425581 227 17 a a DT 10_1101-2021_01_06_425581 227 18 number number NN 10_1101-2021_01_06_425581 227 19 of of IN 10_1101-2021_01_06_425581 227 20 experimental experimental JJ 10_1101-2021_01_06_425581 227 21 settings setting NNS 10_1101-2021_01_06_425581 227 22 . . . 10_1101-2021_01_06_425581 228 1 For for IN 10_1101-2021_01_06_425581 228 2 example example NN 10_1101-2021_01_06_425581 228 3 , , , 10_1101-2021_01_06_425581 228 4 physical physical JJ 10_1101-2021_01_06_425581 228 5 confinement confinement NN 10_1101-2021_01_06_425581 228 6 affects affect VBZ 10_1101-2021_01_06_425581 228 7 the the DT 10_1101-2021_01_06_425581 228 8 overall overall JJ 10_1101-2021_01_06_425581 228 9 axial axial JJ 10_1101-2021_01_06_425581 228 10 alignment alignment NN 10_1101-2021_01_06_425581 228 11 and and CC 10_1101-2021_01_06_425581 228 12 geometry geometry NN 10_1101-2021_01_06_425581 228 13 of of IN 10_1101-2021_01_06_425581 228 14 an an DT 10_1101-2021_01_06_425581 228 15 embryo embryo NN 10_1101-2021_01_06_425581 228 16 [ [ -LRB- 10_1101-2021_01_06_425581 228 17 22 22 CD 10_1101-2021_01_06_425581 228 18 ] ] -RRB- 10_1101-2021_01_06_425581 228 19 . . . 10_1101-2021_01_06_425581 229 1 This this DT 10_1101-2021_01_06_425581 229 2 includes include VBZ 10_1101-2021_01_06_425581 229 3 our -PRON- PRP$ 10_1101-2021_01_06_425581 229 4 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 229 5 embryo embryo NN 10_1101-2021_01_06_425581 229 6 network network NN 10_1101-2021_01_06_425581 229 7 . . . 10_1101-2021_01_06_425581 230 1 Other other JJ 10_1101-2021_01_06_425581 230 2 types type NNS 10_1101-2021_01_06_425581 230 3 of of IN 10_1101-2021_01_06_425581 230 4 fishes fish NNS 10_1101-2021_01_06_425581 230 5 ( ( -LRB- 10_1101-2021_01_06_425581 230 6 Astyanax Astyanax NNP 10_1101-2021_01_06_425581 230 7 , , , 10_1101-2021_01_06_425581 230 8 see see VB 10_1101-2021_01_06_425581 230 9 [ [ -LRB- 10_1101-2021_01_06_425581 230 10 23 23 CD 10_1101-2021_01_06_425581 230 11 ] ] -RRB- 10_1101-2021_01_06_425581 230 12 ) ) -RRB- 10_1101-2021_01_06_425581 230 13 exhibit exhibit VB 10_1101-2021_01_06_425581 230 14 morphological morphological JJ 10_1101-2021_01_06_425581 230 15 changes change NNS 10_1101-2021_01_06_425581 230 16 in in IN 10_1101-2021_01_06_425581 230 17 neural neural JJ 10_1101-2021_01_06_425581 230 18 crest crest NNP 10_1101-2021_01_06_425581 230 19 cell cell NN 10_1101-2021_01_06_425581 230 20 proliferation proliferation NN 10_1101-2021_01_06_425581 230 21 based base VBN 10_1101-2021_01_06_425581 230 22 on on IN 10_1101-2021_01_06_425581 230 23 evolutionary evolutionary JJ 10_1101-2021_01_06_425581 230 24 changes change NNS 10_1101-2021_01_06_425581 230 25 due due JJ 10_1101-2021_01_06_425581 230 26 to to IN 10_1101-2021_01_06_425581 230 27 ecological ecological JJ 10_1101-2021_01_06_425581 230 28 constraints constraint NNS 10_1101-2021_01_06_425581 230 29 . . . 10_1101-2021_01_06_425581 231 1 In in IN 10_1101-2021_01_06_425581 231 2 C. C. NNP 10_1101-2021_01_06_425581 231 3 elegans elegan NNS 10_1101-2021_01_06_425581 231 4 , , , 10_1101-2021_01_06_425581 231 5 asymmetrical asymmetrical JJ 10_1101-2021_01_06_425581 231 6 cells cell NNS 10_1101-2021_01_06_425581 231 7 ( ( -LRB- 10_1101-2021_01_06_425581 231 8 or or CC 10_1101-2021_01_06_425581 231 9 daughter daughter NN 10_1101-2021_01_06_425581 231 10 cells cell NNS 10_1101-2021_01_06_425581 231 11 with with IN 10_1101-2021_01_06_425581 231 12 significantly significantly RB 10_1101-2021_01_06_425581 231 13 different different JJ 10_1101-2021_01_06_425581 231 14 volumes volume NNS 10_1101-2021_01_06_425581 231 15 ) ) -RRB- 10_1101-2021_01_06_425581 231 16 result result VBP 10_1101-2021_01_06_425581 231 17 from from IN 10_1101-2021_01_06_425581 231 18 physical physical JJ 10_1101-2021_01_06_425581 231 19 constraints constraint NNS 10_1101-2021_01_06_425581 231 20 and and CC 10_1101-2021_01_06_425581 231 21 compose compose VB 10_1101-2021_01_06_425581 231 22 40 40 CD 10_1101-2021_01_06_425581 231 23 % % NN 10_1101-2021_01_06_425581 231 24 of of IN 10_1101-2021_01_06_425581 231 25 C. C. NNP 10_1101-2021_01_06_425581 231 26 elegans elegan NNS 10_1101-2021_01_06_425581 231 27 developmental developmental JJ 10_1101-2021_01_06_425581 231 28 cell cell NN 10_1101-2021_01_06_425581 231 29 divisions division NNS 10_1101-2021_01_06_425581 231 30 [ [ -LRB- 10_1101-2021_01_06_425581 231 31 24 24 CD 10_1101-2021_01_06_425581 231 32 , , , 10_1101-2021_01_06_425581 231 33 25 25 CD 10_1101-2021_01_06_425581 231 34 ] ] -RRB- 10_1101-2021_01_06_425581 231 35 . . . 10_1101-2021_01_06_425581 232 1 Asymmetric asymmetric JJ 10_1101-2021_01_06_425581 232 2 cell cell NN 10_1101-2021_01_06_425581 232 3 divisions division NNS 10_1101-2021_01_06_425581 232 4 set set VBN 10_1101-2021_01_06_425581 232 5 up up RP 10_1101-2021_01_06_425581 232 6 key key JJ 10_1101-2021_01_06_425581 232 7 cell cell NN 10_1101-2021_01_06_425581 232 8 - - HYPH 10_1101-2021_01_06_425581 232 9 cell cell NN 10_1101-2021_01_06_425581 232 10 interactions interaction NNS 10_1101-2021_01_06_425581 232 11 [ [ -LRB- 10_1101-2021_01_06_425581 232 12 24 24 CD 10_1101-2021_01_06_425581 232 13 ] ] -RRB- 10_1101-2021_01_06_425581 232 14 that that WDT 10_1101-2021_01_06_425581 232 15 are be VBP 10_1101-2021_01_06_425581 232 16 highlighted highlight VBN 10_1101-2021_01_06_425581 232 17 by by IN 10_1101-2021_01_06_425581 232 18 the the DT 10_1101-2021_01_06_425581 232 19 edges edge NNS 10_1101-2021_01_06_425581 232 20 of of IN 10_1101-2021_01_06_425581 232 21 embryo embryo NN 10_1101-2021_01_06_425581 232 22 networks network NNS 10_1101-2021_01_06_425581 232 23 . . . 10_1101-2021_01_06_425581 233 1 Finally finally RB 10_1101-2021_01_06_425581 233 2 , , , 10_1101-2021_01_06_425581 233 3 by by IN 10_1101-2021_01_06_425581 233 4 comparing compare VBG 10_1101-2021_01_06_425581 233 5 nematic nematic JJ 10_1101-2021_01_06_425581 233 6 11 11 CD 10_1101-2021_01_06_425581 233 7 .CC .CC , 10_1101-2021_01_06_425581 233 8 - - HYPH 10_1101-2021_01_06_425581 233 9 BY BY NNP 10_1101-2021_01_06_425581 233 10 - - HYPH 10_1101-2021_01_06_425581 233 11 NC NC NNP 10_1101-2021_01_06_425581 233 12 4.0 4.0 CD 10_1101-2021_01_06_425581 233 13 International international JJ 10_1101-2021_01_06_425581 233 14 licensemade licensemade NN 10_1101-2021_01_06_425581 233 15 available available JJ 10_1101-2021_01_06_425581 233 16 under under IN 10_1101-2021_01_06_425581 233 17 a a DT 10_1101-2021_01_06_425581 233 18 ( ( -LRB- 10_1101-2021_01_06_425581 233 19 which which WDT 10_1101-2021_01_06_425581 233 20 was be VBD 10_1101-2021_01_06_425581 233 21 not not RB 10_1101-2021_01_06_425581 233 22 certified certify VBN 10_1101-2021_01_06_425581 233 23 by by IN 10_1101-2021_01_06_425581 233 24 peer peer NN 10_1101-2021_01_06_425581 233 25 review review NN 10_1101-2021_01_06_425581 233 26 ) ) -RRB- 10_1101-2021_01_06_425581 233 27 is be VBZ 10_1101-2021_01_06_425581 233 28 the the DT 10_1101-2021_01_06_425581 233 29 author author NN 10_1101-2021_01_06_425581 233 30 / / SYM 10_1101-2021_01_06_425581 233 31 funder funder NN 10_1101-2021_01_06_425581 233 32 , , , 10_1101-2021_01_06_425581 233 33 who who WP 10_1101-2021_01_06_425581 233 34 has have VBZ 10_1101-2021_01_06_425581 233 35 granted grant VBN 10_1101-2021_01_06_425581 233 36 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 233 37 a a DT 10_1101-2021_01_06_425581 233 38 license license NN 10_1101-2021_01_06_425581 233 39 to to TO 10_1101-2021_01_06_425581 233 40 display display VB 10_1101-2021_01_06_425581 233 41 the the DT 10_1101-2021_01_06_425581 233 42 preprint preprint NN 10_1101-2021_01_06_425581 233 43 in in IN 10_1101-2021_01_06_425581 233 44 perpetuity perpetuity NN 10_1101-2021_01_06_425581 233 45 . . . 10_1101-2021_01_06_425581 234 1 It -PRON- PRP 10_1101-2021_01_06_425581 234 2 is be VBZ 10_1101-2021_01_06_425581 234 3 The the DT 10_1101-2021_01_06_425581 234 4 copyright copyright NN 10_1101-2021_01_06_425581 234 5 holder holder NN 10_1101-2021_01_06_425581 234 6 for for IN 10_1101-2021_01_06_425581 234 7 this this DT 10_1101-2021_01_06_425581 234 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 234 9 version version NN 10_1101-2021_01_06_425581 234 10 posted post VBD 10_1101-2021_01_06_425581 234 11 January January NNP 10_1101-2021_01_06_425581 234 12 8 8 CD 10_1101-2021_01_06_425581 234 13 , , , 10_1101-2021_01_06_425581 234 14 2021 2021 CD 10_1101-2021_01_06_425581 234 15 . . . 10_1101-2021_01_06_425581 234 16 ; ; : 10_1101-2021_01_06_425581 234 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 234 18 : : : 10_1101-2021_01_06_425581 234 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 234 20 preprint preprint NN 10_1101-2021_01_06_425581 234 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 234 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 234 23 alignment alignment NN 10_1101-2021_01_06_425581 234 24 of of IN 10_1101-2021_01_06_425581 234 25 liquid liquid JJ 10_1101-2021_01_06_425581 234 26 crystals crystal NNS 10_1101-2021_01_06_425581 234 27 to to IN 10_1101-2021_01_06_425581 234 28 spindles spindle NNS 10_1101-2021_01_06_425581 234 29 of of IN 10_1101-2021_01_06_425581 234 30 mitotic mitotic JJ 10_1101-2021_01_06_425581 234 31 cells cell NNS 10_1101-2021_01_06_425581 234 32 , , , 10_1101-2021_01_06_425581 234 33 phase phase NN 10_1101-2021_01_06_425581 234 34 transitions transition NNS 10_1101-2021_01_06_425581 234 35 in in IN 10_1101-2021_01_06_425581 234 36 actively actively RB 10_1101-2021_01_06_425581 234 37 dividing divide VBG 10_1101-2021_01_06_425581 234 38 cells cell NNS 10_1101-2021_01_06_425581 234 39 are be VBP 10_1101-2021_01_06_425581 234 40 found find VBN 10_1101-2021_01_06_425581 234 41 to to TO 10_1101-2021_01_06_425581 234 42 result result VB 10_1101-2021_01_06_425581 234 43 from from IN 10_1101-2021_01_06_425581 234 44 the the DT 10_1101-2021_01_06_425581 234 45 timing timing NN 10_1101-2021_01_06_425581 234 46 of of IN 10_1101-2021_01_06_425581 234 47 centrosome centrosome NN 10_1101-2021_01_06_425581 234 48 separation separation NN 10_1101-2021_01_06_425581 234 49 [ [ -LRB- 10_1101-2021_01_06_425581 234 50 26 26 CD 10_1101-2021_01_06_425581 234 51 ] ] -RRB- 10_1101-2021_01_06_425581 234 52 . . . 10_1101-2021_01_06_425581 235 1 Figure figure NN 10_1101-2021_01_06_425581 235 2 7 7 CD 10_1101-2021_01_06_425581 235 3 provides provide VBZ 10_1101-2021_01_06_425581 235 4 an an DT 10_1101-2021_01_06_425581 235 5 introduction introduction NN 10_1101-2021_01_06_425581 235 6 to to IN 10_1101-2021_01_06_425581 235 7 the the DT 10_1101-2021_01_06_425581 235 8 numeric numeric JJ 10_1101-2021_01_06_425581 235 9 embryo embryo NN 10_1101-2021_01_06_425581 235 10 concept concept NN 10_1101-2021_01_06_425581 235 11 . . . 10_1101-2021_01_06_425581 236 1 In in IN 10_1101-2021_01_06_425581 236 2 this this DT 10_1101-2021_01_06_425581 236 3 Figure figure NN 10_1101-2021_01_06_425581 236 4 , , , 10_1101-2021_01_06_425581 236 5 we -PRON- PRP 10_1101-2021_01_06_425581 236 6 focus focus VBP 10_1101-2021_01_06_425581 236 7 exclusively exclusively RB 10_1101-2021_01_06_425581 236 8 on on IN 10_1101-2021_01_06_425581 236 9 the the DT 10_1101-2021_01_06_425581 236 10 timing timing NN 10_1101-2021_01_06_425581 236 11 component component NN 10_1101-2021_01_06_425581 236 12 of of IN 10_1101-2021_01_06_425581 236 13 lineage lineage NN 10_1101-2021_01_06_425581 236 14 trees tree NNS 10_1101-2021_01_06_425581 236 15 . . . 10_1101-2021_01_06_425581 237 1 This this DT 10_1101-2021_01_06_425581 237 2 is be VBZ 10_1101-2021_01_06_425581 237 3 essentially essentially RB 10_1101-2021_01_06_425581 237 4 a a DT 10_1101-2021_01_06_425581 237 5 version version NN 10_1101-2021_01_06_425581 237 6 of of IN 10_1101-2021_01_06_425581 237 7 the the DT 10_1101-2021_01_06_425581 237 8 time time NN 10_1101-2021_01_06_425581 237 9 series series NN 10_1101-2021_01_06_425581 237 10 shown show VBN 10_1101-2021_01_06_425581 237 11 for for IN 10_1101-2021_01_06_425581 237 12 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 237 13 and and CC 10_1101-2021_01_06_425581 237 14 ​C. ​c. ADD 10_1101-2021_01_06_425581 238 1 elegans elegans NNPS 10_1101-2021_01_06_425581 238 2 developmental developmental JJ 10_1101-2021_01_06_425581 238 3 time time NN 10_1101-2021_01_06_425581 238 4 series series NN 10_1101-2021_01_06_425581 238 5 , , , 10_1101-2021_01_06_425581 238 6 but but CC 10_1101-2021_01_06_425581 238 7 with with IN 10_1101-2021_01_06_425581 238 8 the the DT 10_1101-2021_01_06_425581 238 9 temporal temporal JJ 10_1101-2021_01_06_425581 238 10 fluctuations fluctuation NNS 10_1101-2021_01_06_425581 238 11 smoothed smooth VBN 10_1101-2021_01_06_425581 238 12 out out RP 10_1101-2021_01_06_425581 238 13 . . . 10_1101-2021_01_06_425581 239 1 These these DT 10_1101-2021_01_06_425581 239 2 fluctuations fluctuation NNS 10_1101-2021_01_06_425581 239 3 are be VBP 10_1101-2021_01_06_425581 239 4 replaced replace VBN 10_1101-2021_01_06_425581 239 5 with with IN 10_1101-2021_01_06_425581 239 6 a a DT 10_1101-2021_01_06_425581 239 7 cumulative cumulative JJ 10_1101-2021_01_06_425581 239 8 sum sum NN 10_1101-2021_01_06_425581 239 9 of of IN 10_1101-2021_01_06_425581 239 10 all all DT 10_1101-2021_01_06_425581 239 11 cell cell NN 10_1101-2021_01_06_425581 239 12 division division NN 10_1101-2021_01_06_425581 239 13 events event NNS 10_1101-2021_01_06_425581 239 14 occurring occur VBG 10_1101-2021_01_06_425581 239 15 over over IN 10_1101-2021_01_06_425581 239 16 a a DT 10_1101-2021_01_06_425581 239 17 certain certain JJ 10_1101-2021_01_06_425581 239 18 period period NN 10_1101-2021_01_06_425581 239 19 of of IN 10_1101-2021_01_06_425581 239 20 time time NN 10_1101-2021_01_06_425581 239 21 . . . 10_1101-2021_01_06_425581 240 1 It -PRON- PRP 10_1101-2021_01_06_425581 240 2 is be VBZ 10_1101-2021_01_06_425581 240 3 also also RB 10_1101-2021_01_06_425581 240 4 apparent apparent JJ 10_1101-2021_01_06_425581 240 5 that that IN 10_1101-2021_01_06_425581 240 6 comparisons comparison NNS 10_1101-2021_01_06_425581 240 7 between between IN 10_1101-2021_01_06_425581 240 8 different different JJ 10_1101-2021_01_06_425581 240 9 distributions distribution NNS 10_1101-2021_01_06_425581 240 10 do do VBP 10_1101-2021_01_06_425581 240 11 not not RB 10_1101-2021_01_06_425581 240 12 yield yield VB 10_1101-2021_01_06_425581 240 13 an an DT 10_1101-2021_01_06_425581 240 14 appreciable appreciable JJ 10_1101-2021_01_06_425581 240 15 difference difference NN 10_1101-2021_01_06_425581 240 16 in in IN 10_1101-2021_01_06_425581 240 17 developmental developmental JJ 10_1101-2021_01_06_425581 240 18 speed speed NN 10_1101-2021_01_06_425581 240 19 ( ( -LRB- 10_1101-2021_01_06_425581 240 20 or or CC 10_1101-2021_01_06_425581 240 21 the the DT 10_1101-2021_01_06_425581 240 22 accumulation accumulation NN 10_1101-2021_01_06_425581 240 23 of of IN 10_1101-2021_01_06_425581 240 24 ​x ​x NN 10_1101-2021_01_06_425581 240 25 cells cell NNS 10_1101-2021_01_06_425581 240 26 over over IN 10_1101-2021_01_06_425581 240 27 a a DT 10_1101-2021_01_06_425581 240 28 certain certain JJ 10_1101-2021_01_06_425581 240 29 period period NN 10_1101-2021_01_06_425581 240 30 of of IN 10_1101-2021_01_06_425581 240 31 time time NN 10_1101-2021_01_06_425581 240 32 ) ) -RRB- 10_1101-2021_01_06_425581 240 33 . . . 10_1101-2021_01_06_425581 241 1 In in IN 10_1101-2021_01_06_425581 241 2 Figure Figure NNP 10_1101-2021_01_06_425581 241 3 7 7 CD 10_1101-2021_01_06_425581 241 4 , , , 10_1101-2021_01_06_425581 241 5 all all DT 10_1101-2021_01_06_425581 241 6 simulations simulation NNS 10_1101-2021_01_06_425581 241 7 were be VBD 10_1101-2021_01_06_425581 241 8 run run VBN 10_1101-2021_01_06_425581 241 9 for for IN 10_1101-2021_01_06_425581 241 10 60 60 CD 10_1101-2021_01_06_425581 241 11 iterations iteration NNS 10_1101-2021_01_06_425581 241 12 . . . 10_1101-2021_01_06_425581 242 1 Investigating investigate VBG 10_1101-2021_01_06_425581 242 2 the the DT 10_1101-2021_01_06_425581 242 3 potential potential NN 10_1101-2021_01_06_425581 242 4 of of IN 10_1101-2021_01_06_425581 242 5 the the DT 10_1101-2021_01_06_425581 242 6 Poisson Poisson NNP 10_1101-2021_01_06_425581 242 7 distribution distribution NN 10_1101-2021_01_06_425581 242 8 further further RB 10_1101-2021_01_06_425581 242 9 , , , 10_1101-2021_01_06_425581 242 10 we -PRON- PRP 10_1101-2021_01_06_425581 242 11 investigate investigate VBP 10_1101-2021_01_06_425581 242 12 how how WRB 10_1101-2021_01_06_425581 242 13 this this DT 10_1101-2021_01_06_425581 242 14 distribution distribution NN 10_1101-2021_01_06_425581 242 15 approximates approximate VBZ 10_1101-2021_01_06_425581 242 16 cumulative cumulative JJ 10_1101-2021_01_06_425581 242 17 cell cell NN 10_1101-2021_01_06_425581 242 18 division division NN 10_1101-2021_01_06_425581 242 19 ( ( -LRB- 10_1101-2021_01_06_425581 242 20 as as IN 10_1101-2021_01_06_425581 242 21 was be VBD 10_1101-2021_01_06_425581 242 22 done do VBN 10_1101-2021_01_06_425581 242 23 in in IN 10_1101-2021_01_06_425581 242 24 Figure Figure NNP 10_1101-2021_01_06_425581 242 25 7 7 CD 10_1101-2021_01_06_425581 242 26 ) ) -RRB- 10_1101-2021_01_06_425581 242 27 for for IN 10_1101-2021_01_06_425581 242 28 three three CD 10_1101-2021_01_06_425581 242 29 values value NNS 10_1101-2021_01_06_425581 242 30 of of IN 10_1101-2021_01_06_425581 242 31 λ λ NN 10_1101-2021_01_06_425581 242 32 ( ( -LRB- 10_1101-2021_01_06_425581 242 33 0.1 0.1 CD 10_1101-2021_01_06_425581 242 34 , , , 10_1101-2021_01_06_425581 242 35 0.5 0.5 CD 10_1101-2021_01_06_425581 242 36 , , , 10_1101-2021_01_06_425581 242 37 and and CC 10_1101-2021_01_06_425581 242 38 1.0 1.0 CD 10_1101-2021_01_06_425581 242 39 ) ) -RRB- 10_1101-2021_01_06_425581 242 40 . . . 10_1101-2021_01_06_425581 243 1 The the DT 10_1101-2021_01_06_425581 243 2 results result NNS 10_1101-2021_01_06_425581 243 3 of of IN 10_1101-2021_01_06_425581 243 4 this this DT 10_1101-2021_01_06_425581 243 5 experiment experiment NN 10_1101-2021_01_06_425581 243 6 are be VBP 10_1101-2021_01_06_425581 243 7 shown show VBN 10_1101-2021_01_06_425581 243 8 in in IN 10_1101-2021_01_06_425581 243 9 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 243 10 Figure Figure NNP 10_1101-2021_01_06_425581 243 11 5 5 CD 10_1101-2021_01_06_425581 243 12 . . . 10_1101-2021_01_06_425581 244 1 As as IN 10_1101-2021_01_06_425581 244 2 this this DT 10_1101-2021_01_06_425581 244 3 parameter parameter NN 10_1101-2021_01_06_425581 244 4 value value NN 10_1101-2021_01_06_425581 244 5 is be VBZ 10_1101-2021_01_06_425581 244 6 increased increase VBN 10_1101-2021_01_06_425581 244 7 , , , 10_1101-2021_01_06_425581 244 8 the the DT 10_1101-2021_01_06_425581 244 9 number number NN 10_1101-2021_01_06_425581 244 10 of of IN 10_1101-2021_01_06_425581 244 11 cells cell NNS 10_1101-2021_01_06_425581 244 12 per per IN 10_1101-2021_01_06_425581 244 13 developmental developmental JJ 10_1101-2021_01_06_425581 244 14 time time NN 10_1101-2021_01_06_425581 244 15 point point NN 10_1101-2021_01_06_425581 244 16 increases increase NNS 10_1101-2021_01_06_425581 244 17 while while IN 10_1101-2021_01_06_425581 244 18 the the DT 10_1101-2021_01_06_425581 244 19 interval interval NN 10_1101-2021_01_06_425581 244 20 between between IN 10_1101-2021_01_06_425581 244 21 cell cell NN 10_1101-2021_01_06_425581 244 22 divisions division NNS 10_1101-2021_01_06_425581 244 23 decreases decrease VBZ 10_1101-2021_01_06_425581 244 24 . . . 10_1101-2021_01_06_425581 245 1 While while IN 10_1101-2021_01_06_425581 245 2 the the DT 10_1101-2021_01_06_425581 245 3 function function NN 10_1101-2021_01_06_425581 245 4 derived derive VBN 10_1101-2021_01_06_425581 245 5 from from IN 10_1101-2021_01_06_425581 245 6 λ λ NN 10_1101-2021_01_06_425581 245 7 = = SYM 10_1101-2021_01_06_425581 245 8 0.1 0.1 CD 10_1101-2021_01_06_425581 245 9 is be VBZ 10_1101-2021_01_06_425581 245 10 always always RB 10_1101-2021_01_06_425581 245 11 slowest slow JJS 10_1101-2021_01_06_425581 245 12 , , , 10_1101-2021_01_06_425581 245 13 the the DT 10_1101-2021_01_06_425581 245 14 functions function NNS 10_1101-2021_01_06_425581 245 15 derived derive VBN 10_1101-2021_01_06_425581 245 16 from from IN 10_1101-2021_01_06_425581 245 17 λ λ NN 10_1101-2021_01_06_425581 245 18 = = SYM 10_1101-2021_01_06_425581 245 19 0.5 0.5 CD 10_1101-2021_01_06_425581 245 20 and and CC 10_1101-2021_01_06_425581 245 21 λ λ NN 10_1101-2021_01_06_425581 245 22 = = SYM 10_1101-2021_01_06_425581 245 23 1.0 1.0 CD 10_1101-2021_01_06_425581 245 24 are be VBP 10_1101-2021_01_06_425581 245 25 similar similar JJ 10_1101-2021_01_06_425581 245 26 for for IN 10_1101-2021_01_06_425581 245 27 the the DT 10_1101-2021_01_06_425581 245 28 first first JJ 10_1101-2021_01_06_425581 245 29 20 20 CD 10_1101-2021_01_06_425581 245 30 timepoints timepoint NNS 10_1101-2021_01_06_425581 245 31 , , , 10_1101-2021_01_06_425581 245 32 then then RB 10_1101-2021_01_06_425581 245 33 diverge diverge VB 10_1101-2021_01_06_425581 245 34 to to TO 10_1101-2021_01_06_425581 245 35 reveal reveal VB 10_1101-2021_01_06_425581 245 36 that that IN 10_1101-2021_01_06_425581 245 37 λ λ NN 10_1101-2021_01_06_425581 245 38 = = SYM 10_1101-2021_01_06_425581 245 39 1.0 1.0 CD 10_1101-2021_01_06_425581 245 40 clearly clearly RB 10_1101-2021_01_06_425581 245 41 results result VBZ 10_1101-2021_01_06_425581 245 42 in in IN 10_1101-2021_01_06_425581 245 43 both both DT 10_1101-2021_01_06_425581 245 44 faster fast JJR 10_1101-2021_01_06_425581 245 45 cell cell NN 10_1101-2021_01_06_425581 245 46 divisions division NNS 10_1101-2021_01_06_425581 245 47 and and CC 10_1101-2021_01_06_425581 245 48 a a DT 10_1101-2021_01_06_425581 245 49 larger large JJR 10_1101-2021_01_06_425581 245 50 number number NN 10_1101-2021_01_06_425581 245 51 of of IN 10_1101-2021_01_06_425581 245 52 total total JJ 10_1101-2021_01_06_425581 245 53 cells cell NNS 10_1101-2021_01_06_425581 245 54 after after IN 10_1101-2021_01_06_425581 245 55 200 200 CD 10_1101-2021_01_06_425581 245 56 iterations iteration NNS 10_1101-2021_01_06_425581 245 57 . . . 10_1101-2021_01_06_425581 246 1 Broader broad JJR 10_1101-2021_01_06_425581 246 2 Questions question NNS 10_1101-2021_01_06_425581 246 3 We -PRON- PRP 10_1101-2021_01_06_425581 246 4 can can MD 10_1101-2021_01_06_425581 246 5 ask ask VB 10_1101-2021_01_06_425581 246 6 what what WP 10_1101-2021_01_06_425581 246 7 it -PRON- PRP 10_1101-2021_01_06_425581 246 8 means mean VBZ 10_1101-2021_01_06_425581 246 9 when when WRB 10_1101-2021_01_06_425581 246 10 embryogenetic embryogenetic JJ 10_1101-2021_01_06_425581 246 11 systems system NNS 10_1101-2021_01_06_425581 246 12 exhibit exhibit VBP 10_1101-2021_01_06_425581 246 13 multiple multiple JJ 10_1101-2021_01_06_425581 246 14 pulses pulse NNS 10_1101-2021_01_06_425581 246 15 of of IN 10_1101-2021_01_06_425581 246 16 cell cell NN 10_1101-2021_01_06_425581 246 17 proliferation proliferation NN 10_1101-2021_01_06_425581 246 18 from from IN 10_1101-2021_01_06_425581 246 19 division division NN 10_1101-2021_01_06_425581 246 20 events event NNS 10_1101-2021_01_06_425581 246 21 . . . 10_1101-2021_01_06_425581 247 1 In in IN 10_1101-2021_01_06_425581 247 2 particular particular JJ 10_1101-2021_01_06_425581 247 3 , , , 10_1101-2021_01_06_425581 247 4 the the DT 10_1101-2021_01_06_425581 247 5 intervals interval NNS 10_1101-2021_01_06_425581 247 6 between between IN 10_1101-2021_01_06_425581 247 7 pulses pulse NNS 10_1101-2021_01_06_425581 247 8 provide provide VBP 10_1101-2021_01_06_425581 247 9 information information NN 10_1101-2021_01_06_425581 247 10 about about IN 10_1101-2021_01_06_425581 247 11 the the DT 10_1101-2021_01_06_425581 247 12 generative generative JJ 10_1101-2021_01_06_425581 247 13 mechanisms mechanism NNS 10_1101-2021_01_06_425581 247 14 behind behind IN 10_1101-2021_01_06_425581 247 15 production production NN 10_1101-2021_01_06_425581 247 16 of of IN 10_1101-2021_01_06_425581 247 17 the the DT 10_1101-2021_01_06_425581 247 18 embryo embryo NN 10_1101-2021_01_06_425581 247 19 . . . 10_1101-2021_01_06_425581 248 1 Our -PRON- PRP$ 10_1101-2021_01_06_425581 248 2 inquiry inquiry NN 10_1101-2021_01_06_425581 248 3 is be VBZ 10_1101-2021_01_06_425581 248 4 particularly particularly RB 10_1101-2021_01_06_425581 248 5 suited suit VBN 10_1101-2021_01_06_425581 248 6 to to IN 10_1101-2021_01_06_425581 248 7 quantitative quantitative JJ 10_1101-2021_01_06_425581 248 8 interpretation interpretation NN 10_1101-2021_01_06_425581 248 9 , , , 10_1101-2021_01_06_425581 248 10 particularly particularly RB 10_1101-2021_01_06_425581 248 11 in in IN 10_1101-2021_01_06_425581 248 12 terms term NNS 10_1101-2021_01_06_425581 248 13 of of IN 10_1101-2021_01_06_425581 248 14 characterizing characterize VBG 10_1101-2021_01_06_425581 248 15 " " `` 10_1101-2021_01_06_425581 248 16 bursty bursty JJ 10_1101-2021_01_06_425581 248 17 " " '' 10_1101-2021_01_06_425581 248 18 behaviors behavior NNS 10_1101-2021_01_06_425581 248 19 . . . 10_1101-2021_01_06_425581 249 1 These these DT 10_1101-2021_01_06_425581 249 2 bursty bursty JJ 10_1101-2021_01_06_425581 249 3 behaviors behavior NNS 10_1101-2021_01_06_425581 249 4 are be VBP 10_1101-2021_01_06_425581 249 5 non non JJ 10_1101-2021_01_06_425581 249 6 - - JJ 10_1101-2021_01_06_425581 249 7 normally normally RB 10_1101-2021_01_06_425581 249 8 distributed distribute VBN 10_1101-2021_01_06_425581 249 9 generative generative JJ 10_1101-2021_01_06_425581 249 10 processes process NNS 10_1101-2021_01_06_425581 249 11 [ [ -LRB- 10_1101-2021_01_06_425581 249 12 27 27 CD 10_1101-2021_01_06_425581 249 13 ] ] -RRB- 10_1101-2021_01_06_425581 249 14 that that WDT 10_1101-2021_01_06_425581 249 15 describe describe VBP 10_1101-2021_01_06_425581 249 16 the the DT 10_1101-2021_01_06_425581 249 17 tempo tempo NN 10_1101-2021_01_06_425581 249 18 and and CC 10_1101-2021_01_06_425581 249 19 mode mode NN 10_1101-2021_01_06_425581 249 20 of of IN 10_1101-2021_01_06_425581 249 21 development development NN 10_1101-2021_01_06_425581 249 22 . . . 10_1101-2021_01_06_425581 250 1 While while IN 10_1101-2021_01_06_425581 250 2 tempo tempo NN 10_1101-2021_01_06_425581 250 3 and and CC 10_1101-2021_01_06_425581 250 4 mode mode NN 10_1101-2021_01_06_425581 250 5 is be VBZ 10_1101-2021_01_06_425581 250 6 generally generally RB 10_1101-2021_01_06_425581 250 7 an an DT 10_1101-2021_01_06_425581 250 8 evolutionary evolutionary JJ 10_1101-2021_01_06_425581 250 9 phenomenon phenomenon NN 10_1101-2021_01_06_425581 250 10 , , , 10_1101-2021_01_06_425581 250 11 these these DT 10_1101-2021_01_06_425581 250 12 concepts concept NNS 10_1101-2021_01_06_425581 250 13 also also RB 10_1101-2021_01_06_425581 250 14 yield yield VBP 10_1101-2021_01_06_425581 250 15 a a DT 10_1101-2021_01_06_425581 250 16 model model NN 10_1101-2021_01_06_425581 250 17 of of IN 10_1101-2021_01_06_425581 250 18 developmental developmental JJ 10_1101-2021_01_06_425581 250 19 regulation regulation NN 10_1101-2021_01_06_425581 250 20 that that WDT 10_1101-2021_01_06_425581 250 21 is be VBZ 10_1101-2021_01_06_425581 250 22 explicitly explicitly RB 10_1101-2021_01_06_425581 250 23 temporal temporal JJ 10_1101-2021_01_06_425581 250 24 . . . 10_1101-2021_01_06_425581 251 1 Our -PRON- PRP$ 10_1101-2021_01_06_425581 251 2 results result NNS 10_1101-2021_01_06_425581 251 3 also also RB 10_1101-2021_01_06_425581 251 4 suggest suggest VBP 10_1101-2021_01_06_425581 251 5 that that IN 10_1101-2021_01_06_425581 251 6 developmental developmental JJ 10_1101-2021_01_06_425581 251 7 regulation regulation NN 10_1101-2021_01_06_425581 251 8 is be VBZ 10_1101-2021_01_06_425581 251 9 not not RB 10_1101-2021_01_06_425581 251 10 simply simply RB 10_1101-2021_01_06_425581 251 11 a a DT 10_1101-2021_01_06_425581 251 12 molecular molecular JJ 10_1101-2021_01_06_425581 251 13 mechanism mechanism NN 10_1101-2021_01_06_425581 251 14 . . . 10_1101-2021_01_06_425581 252 1 Our -PRON- PRP$ 10_1101-2021_01_06_425581 252 2 network network NN 10_1101-2021_01_06_425581 252 3 analysis analysis NN 10_1101-2021_01_06_425581 252 4 also also RB 10_1101-2021_01_06_425581 252 5 demonstrates demonstrate VBZ 10_1101-2021_01_06_425581 252 6 a a DT 10_1101-2021_01_06_425581 252 7 connection connection NN 10_1101-2021_01_06_425581 252 8 between between IN 10_1101-2021_01_06_425581 252 9 the the DT 10_1101-2021_01_06_425581 252 10 spatiotemporal spatiotemporal JJ 10_1101-2021_01_06_425581 252 11 dynamics dynamic NNS 10_1101-2021_01_06_425581 252 12 of of IN 10_1101-2021_01_06_425581 252 13 cell cell NN 10_1101-2021_01_06_425581 252 14 division division NN 10_1101-2021_01_06_425581 252 15 , , , 10_1101-2021_01_06_425581 252 16 cell cell NN 10_1101-2021_01_06_425581 252 17 differentiation differentiation NN 10_1101-2021_01_06_425581 252 18 , , , 10_1101-2021_01_06_425581 252 19 and and CC 10_1101-2021_01_06_425581 252 20 systems system NNS 10_1101-2021_01_06_425581 252 21 - - HYPH 10_1101-2021_01_06_425581 252 22 level level NN 10_1101-2021_01_06_425581 252 23 view view NN 10_1101-2021_01_06_425581 252 24 of of IN 10_1101-2021_01_06_425581 252 25 timing timing NN 10_1101-2021_01_06_425581 252 26 . . . 10_1101-2021_01_06_425581 253 1 For for IN 10_1101-2021_01_06_425581 253 2 example example NN 10_1101-2021_01_06_425581 253 3 , , , 10_1101-2021_01_06_425581 253 4 we -PRON- PRP 10_1101-2021_01_06_425581 253 5 have have VBP 10_1101-2021_01_06_425581 253 6 found find VBN 10_1101-2021_01_06_425581 253 7 that that DT 10_1101-2021_01_06_425581 253 8 structure structure NN 10_1101-2021_01_06_425581 253 9 and and CC 10_1101-2021_01_06_425581 253 10 timing timing NN 10_1101-2021_01_06_425581 253 11 of of IN 10_1101-2021_01_06_425581 253 12 interactions interaction NNS 10_1101-2021_01_06_425581 253 13 shape shape NN 10_1101-2021_01_06_425581 253 14 embryo embryo NN 10_1101-2021_01_06_425581 253 15 network network NN 10_1101-2021_01_06_425581 253 16 coherence coherence NN 10_1101-2021_01_06_425581 253 17 signaling signal VBG 10_1101-2021_01_06_425581 253 18 [ [ -LRB- 10_1101-2021_01_06_425581 253 19 28 28 CD 10_1101-2021_01_06_425581 253 20 ] ] -RRB- 10_1101-2021_01_06_425581 253 21 , , , 10_1101-2021_01_06_425581 253 22 which which WDT 10_1101-2021_01_06_425581 253 23 in in IN 10_1101-2021_01_06_425581 253 24 turn turn NN 10_1101-2021_01_06_425581 253 25 is be VBZ 10_1101-2021_01_06_425581 253 26 an an DT 10_1101-2021_01_06_425581 253 27 indicator indicator NN 10_1101-2021_01_06_425581 253 28 of of IN 10_1101-2021_01_06_425581 253 29 diffusion diffusion NN 10_1101-2021_01_06_425581 253 30 between between IN 10_1101-2021_01_06_425581 253 31 developmental developmental JJ 10_1101-2021_01_06_425581 253 32 cells cell NNS 10_1101-2021_01_06_425581 253 33 that that WDT 10_1101-2021_01_06_425581 253 34 share share VBP 10_1101-2021_01_06_425581 253 35 network network NN 10_1101-2021_01_06_425581 253 36 connections connection NNS 10_1101-2021_01_06_425581 253 37 . . . 10_1101-2021_01_06_425581 254 1 While while IN 10_1101-2021_01_06_425581 254 2 it -PRON- PRP 10_1101-2021_01_06_425581 254 3 is be VBZ 10_1101-2021_01_06_425581 254 4 not not RB 10_1101-2021_01_06_425581 254 5 discussed discuss VBN 10_1101-2021_01_06_425581 254 6 in in IN 10_1101-2021_01_06_425581 254 7 this this DT 10_1101-2021_01_06_425581 254 8 paper paper NN 10_1101-2021_01_06_425581 254 9 , , , 10_1101-2021_01_06_425581 254 10 gene gene NN 10_1101-2021_01_06_425581 254 11 expression expression NN 10_1101-2021_01_06_425581 254 12 fluctuations fluctuation NNS 10_1101-2021_01_06_425581 254 13 and and CC 10_1101-2021_01_06_425581 254 14 stochastic stochastic JJ 10_1101-2021_01_06_425581 254 15 noise noise NN 10_1101-2021_01_06_425581 254 16 in in IN 10_1101-2021_01_06_425581 254 17 gene gene NN 10_1101-2021_01_06_425581 254 18 expression expression NN 10_1101-2021_01_06_425581 254 19 drives drive VBZ 10_1101-2021_01_06_425581 254 20 heterogeneity heterogeneity NN 10_1101-2021_01_06_425581 254 21 in in IN 10_1101-2021_01_06_425581 254 22 division division NN 10_1101-2021_01_06_425581 254 23 timing timing NN 10_1101-2021_01_06_425581 254 24 and and CC 10_1101-2021_01_06_425581 254 25 even even RB 10_1101-2021_01_06_425581 254 26 timing timing NN 10_1101-2021_01_06_425581 254 27 of of IN 10_1101-2021_01_06_425581 254 28 differentiation differentiation NN 10_1101-2021_01_06_425581 254 29 [ [ -LRB- 10_1101-2021_01_06_425581 254 30 29 29 CD 10_1101-2021_01_06_425581 254 31 , , , 10_1101-2021_01_06_425581 254 32 30 30 CD 10_1101-2021_01_06_425581 254 33 ] ] -RRB- 10_1101-2021_01_06_425581 254 34 . . . 10_1101-2021_01_06_425581 255 1 In in IN 10_1101-2021_01_06_425581 255 2 particular particular JJ 10_1101-2021_01_06_425581 255 3 , , , 10_1101-2021_01_06_425581 255 4 a a DT 10_1101-2021_01_06_425581 255 5 focus focus NN 10_1101-2021_01_06_425581 255 6 on on IN 10_1101-2021_01_06_425581 255 7 the the DT 10_1101-2021_01_06_425581 255 8 molecular molecular JJ 10_1101-2021_01_06_425581 255 9 biology biology NN 10_1101-2021_01_06_425581 255 10 of of IN 10_1101-2021_01_06_425581 255 11 the the DT 10_1101-2021_01_06_425581 255 12 cell cell NN 10_1101-2021_01_06_425581 255 13 cycle cycle NN 10_1101-2021_01_06_425581 255 14 across across IN 10_1101-2021_01_06_425581 255 15 groups group NNS 10_1101-2021_01_06_425581 255 16 of of IN 10_1101-2021_01_06_425581 255 17 developmental developmental JJ 10_1101-2021_01_06_425581 255 18 cells cell NNS 10_1101-2021_01_06_425581 255 19 [ [ -LRB- 10_1101-2021_01_06_425581 255 20 31 31 CD 10_1101-2021_01_06_425581 255 21 , , , 10_1101-2021_01_06_425581 255 22 32 32 CD 10_1101-2021_01_06_425581 255 23 ] ] -RRB- 10_1101-2021_01_06_425581 255 24 can can MD 10_1101-2021_01_06_425581 255 25 provide provide VB 10_1101-2021_01_06_425581 255 26 more more JJR 10_1101-2021_01_06_425581 255 27 information information NN 10_1101-2021_01_06_425581 255 28 about about IN 10_1101-2021_01_06_425581 255 29 how how WRB 10_1101-2021_01_06_425581 255 30 fluctuations fluctuation NNS 10_1101-2021_01_06_425581 255 31 work work VBP 10_1101-2021_01_06_425581 255 32 in in IN 10_1101-2021_01_06_425581 255 33 general general JJ 10_1101-2021_01_06_425581 255 34 at at IN 10_1101-2021_01_06_425581 255 35 the the DT 10_1101-2021_01_06_425581 255 36 single single JJ 10_1101-2021_01_06_425581 255 37 - - HYPH 10_1101-2021_01_06_425581 255 38 cell cell NN 10_1101-2021_01_06_425581 255 39 level level NN 10_1101-2021_01_06_425581 255 40 . . . 10_1101-2021_01_06_425581 256 1 Yet yet CC 10_1101-2021_01_06_425581 256 2 single single JJ 10_1101-2021_01_06_425581 256 3 cells cell NNS 10_1101-2021_01_06_425581 256 4 acting act VBG 10_1101-2021_01_06_425581 256 5 in in IN 10_1101-2021_01_06_425581 256 6 synchrony synchrony NN 10_1101-2021_01_06_425581 256 7 ( ( -LRB- 10_1101-2021_01_06_425581 256 8 or or CC 10_1101-2021_01_06_425581 256 9 in in IN 10_1101-2021_01_06_425581 256 10 the the DT 10_1101-2021_01_06_425581 256 11 aggregate aggregate NN 10_1101-2021_01_06_425581 256 12 ) ) -RRB- 10_1101-2021_01_06_425581 256 13 define define VB 10_1101-2021_01_06_425581 256 14 the the DT 10_1101-2021_01_06_425581 256 15 patterns pattern NNS 10_1101-2021_01_06_425581 256 16 observed observe VBN 10_1101-2021_01_06_425581 256 17 in in IN 10_1101-2021_01_06_425581 256 18 our -PRON- PRP$ 10_1101-2021_01_06_425581 256 19 empirical empirical JJ 10_1101-2021_01_06_425581 256 20 data datum NNS 10_1101-2021_01_06_425581 256 21 . . . 10_1101-2021_01_06_425581 257 1 One one CD 10_1101-2021_01_06_425581 257 2 way way NN 10_1101-2021_01_06_425581 257 3 to to TO 10_1101-2021_01_06_425581 257 4 generalize generalize VB 10_1101-2021_01_06_425581 257 5 our -PRON- PRP$ 10_1101-2021_01_06_425581 257 6 results result NNS 10_1101-2021_01_06_425581 257 7 to to IN 10_1101-2021_01_06_425581 257 8 a a DT 10_1101-2021_01_06_425581 257 9 broader broad JJR 10_1101-2021_01_06_425581 257 10 cross cross NN 10_1101-2021_01_06_425581 257 11 - - NN 10_1101-2021_01_06_425581 257 12 species species JJ 10_1101-2021_01_06_425581 257 13 context context NN 10_1101-2021_01_06_425581 257 14 is be VBZ 10_1101-2021_01_06_425581 257 15 to to TO 10_1101-2021_01_06_425581 257 16 examine examine VB 10_1101-2021_01_06_425581 257 17 related related JJ 10_1101-2021_01_06_425581 257 18 phenomena phenomenon NNS 10_1101-2021_01_06_425581 257 19 such such JJ 10_1101-2021_01_06_425581 257 20 as as IN 10_1101-2021_01_06_425581 257 21 mitotic mitotic JJ 10_1101-2021_01_06_425581 257 22 bookmarking bookmarking NN 10_1101-2021_01_06_425581 257 23 [ [ -LRB- 10_1101-2021_01_06_425581 257 24 33 33 CD 10_1101-2021_01_06_425581 257 25 ] ] -RRB- 10_1101-2021_01_06_425581 257 26 , , , 10_1101-2021_01_06_425581 257 27 in in IN 10_1101-2021_01_06_425581 257 28 which which WDT 10_1101-2021_01_06_425581 257 29 heritable heritable JJ 10_1101-2021_01_06_425581 257 30 regulatory regulatory JJ 10_1101-2021_01_06_425581 257 31 information information NN 10_1101-2021_01_06_425581 257 32 is be VBZ 10_1101-2021_01_06_425581 257 33 transmitted transmit VBN 10_1101-2021_01_06_425581 257 34 from from IN 10_1101-2021_01_06_425581 257 35 mother mother NN 10_1101-2021_01_06_425581 257 36 to to IN 10_1101-2021_01_06_425581 257 37 daughter daughter NN 10_1101-2021_01_06_425581 257 38 cells cell NNS 10_1101-2021_01_06_425581 257 39 in in IN 10_1101-2021_01_06_425581 257 40 a a DT 10_1101-2021_01_06_425581 257 41 cell cell NN 10_1101-2021_01_06_425581 257 42 lineage lineage NN 10_1101-2021_01_06_425581 257 43 . . . 10_1101-2021_01_06_425581 258 1 12 12 CD 10_1101-2021_01_06_425581 258 2 .CC .CC : 10_1101-2021_01_06_425581 258 3 - - HYPH 10_1101-2021_01_06_425581 258 4 BY BY NNP 10_1101-2021_01_06_425581 258 5 - - HYPH 10_1101-2021_01_06_425581 258 6 NC NC NNP 10_1101-2021_01_06_425581 258 7 4.0 4.0 CD 10_1101-2021_01_06_425581 258 8 International international JJ 10_1101-2021_01_06_425581 258 9 licensemade licensemade NN 10_1101-2021_01_06_425581 258 10 available available JJ 10_1101-2021_01_06_425581 258 11 under under IN 10_1101-2021_01_06_425581 258 12 a a DT 10_1101-2021_01_06_425581 258 13 ( ( -LRB- 10_1101-2021_01_06_425581 258 14 which which WDT 10_1101-2021_01_06_425581 258 15 was be VBD 10_1101-2021_01_06_425581 258 16 not not RB 10_1101-2021_01_06_425581 258 17 certified certify VBN 10_1101-2021_01_06_425581 258 18 by by IN 10_1101-2021_01_06_425581 258 19 peer peer NN 10_1101-2021_01_06_425581 258 20 review review NN 10_1101-2021_01_06_425581 258 21 ) ) -RRB- 10_1101-2021_01_06_425581 258 22 is be VBZ 10_1101-2021_01_06_425581 258 23 the the DT 10_1101-2021_01_06_425581 258 24 author author NN 10_1101-2021_01_06_425581 258 25 / / SYM 10_1101-2021_01_06_425581 258 26 funder funder NN 10_1101-2021_01_06_425581 258 27 , , , 10_1101-2021_01_06_425581 258 28 who who WP 10_1101-2021_01_06_425581 258 29 has have VBZ 10_1101-2021_01_06_425581 258 30 granted grant VBN 10_1101-2021_01_06_425581 258 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 258 32 a a DT 10_1101-2021_01_06_425581 258 33 license license NN 10_1101-2021_01_06_425581 258 34 to to TO 10_1101-2021_01_06_425581 258 35 display display VB 10_1101-2021_01_06_425581 258 36 the the DT 10_1101-2021_01_06_425581 258 37 preprint preprint NN 10_1101-2021_01_06_425581 258 38 in in IN 10_1101-2021_01_06_425581 258 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 258 40 . . . 10_1101-2021_01_06_425581 259 1 It -PRON- PRP 10_1101-2021_01_06_425581 259 2 is be VBZ 10_1101-2021_01_06_425581 259 3 The the DT 10_1101-2021_01_06_425581 259 4 copyright copyright NN 10_1101-2021_01_06_425581 259 5 holder holder NN 10_1101-2021_01_06_425581 259 6 for for IN 10_1101-2021_01_06_425581 259 7 this this DT 10_1101-2021_01_06_425581 259 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 259 9 version version NN 10_1101-2021_01_06_425581 259 10 posted post VBD 10_1101-2021_01_06_425581 259 11 January January NNP 10_1101-2021_01_06_425581 259 12 8 8 CD 10_1101-2021_01_06_425581 259 13 , , , 10_1101-2021_01_06_425581 259 14 2021 2021 CD 10_1101-2021_01_06_425581 259 15 . . . 10_1101-2021_01_06_425581 259 16 ; ; : 10_1101-2021_01_06_425581 259 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 259 18 : : : 10_1101-2021_01_06_425581 259 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 259 20 preprint preprint NN 10_1101-2021_01_06_425581 259 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 ADD 10_1101-2021_01_06_425581 259 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ VB 10_1101-2021_01_06_425581 259 23 Our -PRON- PRP$ 10_1101-2021_01_06_425581 259 24 approach approach NN 10_1101-2021_01_06_425581 259 25 is be VBZ 10_1101-2021_01_06_425581 259 26 also also RB 10_1101-2021_01_06_425581 259 27 quite quite RB 10_1101-2021_01_06_425581 259 28 valuable valuable JJ 10_1101-2021_01_06_425581 259 29 [ [ -LRB- 10_1101-2021_01_06_425581 259 30 see see VBP 10_1101-2021_01_06_425581 259 31 34 34 CD 10_1101-2021_01_06_425581 259 32 ] ] -RRB- 10_1101-2021_01_06_425581 259 33 for for IN 10_1101-2021_01_06_425581 259 34 understanding understand VBG 10_1101-2021_01_06_425581 259 35 this this DT 10_1101-2021_01_06_425581 259 36 particular particular JJ 10_1101-2021_01_06_425581 259 37 scale scale NN 10_1101-2021_01_06_425581 259 38 of of IN 10_1101-2021_01_06_425581 259 39 the the DT 10_1101-2021_01_06_425581 259 40 biological biological JJ 10_1101-2021_01_06_425581 259 41 organism organism NN 10_1101-2021_01_06_425581 259 42 . . . 10_1101-2021_01_06_425581 260 1 To to TO 10_1101-2021_01_06_425581 260 2 understand understand VB 10_1101-2021_01_06_425581 260 3 these these DT 10_1101-2021_01_06_425581 260 4 results result NNS 10_1101-2021_01_06_425581 260 5 more more RBR 10_1101-2021_01_06_425581 260 6 fully fully RB 10_1101-2021_01_06_425581 260 7 in in IN 10_1101-2021_01_06_425581 260 8 the the DT 10_1101-2021_01_06_425581 260 9 context context NN 10_1101-2021_01_06_425581 260 10 of of IN 10_1101-2021_01_06_425581 260 11 groups group NNS 10_1101-2021_01_06_425581 260 12 of of IN 10_1101-2021_01_06_425581 260 13 cells cell NNS 10_1101-2021_01_06_425581 260 14 producing produce VBG 10_1101-2021_01_06_425581 260 15 mean mean JJ 10_1101-2021_01_06_425581 260 16 behaviors behavior NNS 10_1101-2021_01_06_425581 260 17 , , , 10_1101-2021_01_06_425581 260 18 we -PRON- PRP 10_1101-2021_01_06_425581 260 19 can can MD 10_1101-2021_01_06_425581 260 20 appeal appeal VB 10_1101-2021_01_06_425581 260 21 to to IN 10_1101-2021_01_06_425581 260 22 the the DT 10_1101-2021_01_06_425581 260 23 quantal quantal JJ 10_1101-2021_01_06_425581 260 24 mitosis mitosis NN 10_1101-2021_01_06_425581 260 25 hypothesis hypothesis NN 10_1101-2021_01_06_425581 260 26 . . . 10_1101-2021_01_06_425581 261 1 Quantal quantal JJ 10_1101-2021_01_06_425581 261 2 mitosis mitosis NN 10_1101-2021_01_06_425581 261 3 involves involve VBZ 10_1101-2021_01_06_425581 261 4 changes change NNS 10_1101-2021_01_06_425581 261 5 in in IN 10_1101-2021_01_06_425581 261 6 gene gene NN 10_1101-2021_01_06_425581 261 7 expression expression NN 10_1101-2021_01_06_425581 261 8 , , , 10_1101-2021_01_06_425581 261 9 in in IN 10_1101-2021_01_06_425581 261 10 which which WDT 10_1101-2021_01_06_425581 261 11 the the DT 10_1101-2021_01_06_425581 261 12 fate fate NN 10_1101-2021_01_06_425581 261 13 depends depend VBZ 10_1101-2021_01_06_425581 261 14 upon upon IN 10_1101-2021_01_06_425581 261 15 mitosis mitosis NN 10_1101-2021_01_06_425581 261 16 . . . 10_1101-2021_01_06_425581 262 1 This this DT 10_1101-2021_01_06_425581 262 2 is be VBZ 10_1101-2021_01_06_425581 262 3 also also RB 10_1101-2021_01_06_425581 262 4 a a DT 10_1101-2021_01_06_425581 262 5 gene gene NN 10_1101-2021_01_06_425581 262 6 expression expression NN 10_1101-2021_01_06_425581 262 7 - - HYPH 10_1101-2021_01_06_425581 262 8 related relate VBN 10_1101-2021_01_06_425581 262 9 memory memory NN 10_1101-2021_01_06_425581 262 10 mechanism mechanism NN 10_1101-2021_01_06_425581 262 11 that that WDT 10_1101-2021_01_06_425581 262 12 is be VBZ 10_1101-2021_01_06_425581 262 13 widespread widespread JJ 10_1101-2021_01_06_425581 262 14 in in IN 10_1101-2021_01_06_425581 262 15 development development NN 10_1101-2021_01_06_425581 262 16 [ [ -LRB- 10_1101-2021_01_06_425581 262 17 33 33 CD 10_1101-2021_01_06_425581 262 18 ] ] -RRB- 10_1101-2021_01_06_425581 262 19 . . . 10_1101-2021_01_06_425581 263 1 In in IN 10_1101-2021_01_06_425581 263 2 cases case NNS 10_1101-2021_01_06_425581 263 3 of of IN 10_1101-2021_01_06_425581 263 4 an an DT 10_1101-2021_01_06_425581 263 5 observed observed JJ 10_1101-2021_01_06_425581 263 6 wave wave NN 10_1101-2021_01_06_425581 263 7 or or CC 10_1101-2021_01_06_425581 263 8 peak peak VB 10_1101-2021_01_06_425581 263 9 in in IN 10_1101-2021_01_06_425581 263 10 cell cell NN 10_1101-2021_01_06_425581 263 11 divisions division NNS 10_1101-2021_01_06_425581 263 12 at at IN 10_1101-2021_01_06_425581 263 13 a a DT 10_1101-2021_01_06_425581 263 14 certain certain JJ 10_1101-2021_01_06_425581 263 15 point point NN 10_1101-2021_01_06_425581 263 16 in in IN 10_1101-2021_01_06_425581 263 17 developmental developmental JJ 10_1101-2021_01_06_425581 263 18 time time NN 10_1101-2021_01_06_425581 263 19 , , , 10_1101-2021_01_06_425581 263 20 mitosis mitosis NN 10_1101-2021_01_06_425581 263 21 provides provide VBZ 10_1101-2021_01_06_425581 263 22 an an DT 10_1101-2021_01_06_425581 263 23 opportunity opportunity NN 10_1101-2021_01_06_425581 263 24 to to TO 10_1101-2021_01_06_425581 263 25 change change VB 10_1101-2021_01_06_425581 263 26 gene gene NN 10_1101-2021_01_06_425581 263 27 expression expression NN 10_1101-2021_01_06_425581 263 28 [ [ -LRB- 10_1101-2021_01_06_425581 263 29 35 35 CD 10_1101-2021_01_06_425581 263 30 ] ] -RRB- 10_1101-2021_01_06_425581 263 31 , , , 10_1101-2021_01_06_425581 263 32 and and CC 10_1101-2021_01_06_425581 263 33 ultimately ultimately RB 10_1101-2021_01_06_425581 263 34 serves serve VBZ 10_1101-2021_01_06_425581 263 35 as as IN 10_1101-2021_01_06_425581 263 36 a a DT 10_1101-2021_01_06_425581 263 37 collective collective JJ 10_1101-2021_01_06_425581 263 38 signal signal NN 10_1101-2021_01_06_425581 263 39 for for IN 10_1101-2021_01_06_425581 263 40 changes change NNS 10_1101-2021_01_06_425581 263 41 in in IN 10_1101-2021_01_06_425581 263 42 cell cell NN 10_1101-2021_01_06_425581 263 43 fate fate NN 10_1101-2021_01_06_425581 263 44 [ [ -LRB- 10_1101-2021_01_06_425581 263 45 36 36 CD 10_1101-2021_01_06_425581 263 46 ] ] -RRB- 10_1101-2021_01_06_425581 263 47 . . . 10_1101-2021_01_06_425581 264 1 Finally finally RB 10_1101-2021_01_06_425581 264 2 , , , 10_1101-2021_01_06_425581 264 3 the the DT 10_1101-2021_01_06_425581 264 4 way way NN 10_1101-2021_01_06_425581 264 5 in in IN 10_1101-2021_01_06_425581 264 6 which which WDT 10_1101-2021_01_06_425581 264 7 we -PRON- PRP 10_1101-2021_01_06_425581 264 8 decompose decompose VBP 10_1101-2021_01_06_425581 264 9 the the DT 10_1101-2021_01_06_425581 264 10 spatiotemporal spatiotemporal JJ 10_1101-2021_01_06_425581 264 11 dynamics dynamic NNS 10_1101-2021_01_06_425581 264 12 of of IN 10_1101-2021_01_06_425581 264 13 the the DT 10_1101-2021_01_06_425581 264 14 embryo embryo NN 10_1101-2021_01_06_425581 264 15 might may MD 10_1101-2021_01_06_425581 264 16 be be VB 10_1101-2021_01_06_425581 264 17 useful useful JJ 10_1101-2021_01_06_425581 264 18 as as IN 10_1101-2021_01_06_425581 264 19 a a DT 10_1101-2021_01_06_425581 264 20 supplement supplement NN 10_1101-2021_01_06_425581 264 21 to to IN 10_1101-2021_01_06_425581 264 22 reaction reaction NN 10_1101-2021_01_06_425581 264 23 - - HYPH 10_1101-2021_01_06_425581 264 24 diffusion diffusion NN 10_1101-2021_01_06_425581 264 25 models model NNS 10_1101-2021_01_06_425581 264 26 of of IN 10_1101-2021_01_06_425581 264 27 morphogenesis morphogenesis NN 10_1101-2021_01_06_425581 264 28 [ [ -LRB- 10_1101-2021_01_06_425581 264 29 37 37 CD 10_1101-2021_01_06_425581 264 30 ] ] -RRB- 10_1101-2021_01_06_425581 264 31 . . . 10_1101-2021_01_06_425581 265 1 Future future JJ 10_1101-2021_01_06_425581 265 2 work work NN 10_1101-2021_01_06_425581 265 3 will will MD 10_1101-2021_01_06_425581 265 4 involve involve VB 10_1101-2021_01_06_425581 265 5 extending extend VBG 10_1101-2021_01_06_425581 265 6 this this DT 10_1101-2021_01_06_425581 265 7 type type NN 10_1101-2021_01_06_425581 265 8 of of IN 10_1101-2021_01_06_425581 265 9 analysis analysis NN 10_1101-2021_01_06_425581 265 10 to to IN 10_1101-2021_01_06_425581 265 11 other other JJ 10_1101-2021_01_06_425581 265 12 species specie NNS 10_1101-2021_01_06_425581 265 13 , , , 10_1101-2021_01_06_425581 265 14 in in IN 10_1101-2021_01_06_425581 265 15 addition addition NN 10_1101-2021_01_06_425581 265 16 to to IN 10_1101-2021_01_06_425581 265 17 developing develop VBG 10_1101-2021_01_06_425581 265 18 our -PRON- PRP$ 10_1101-2021_01_06_425581 265 19 numerical numerical JJ 10_1101-2021_01_06_425581 265 20 models model NNS 10_1101-2021_01_06_425581 265 21 to to TO 10_1101-2021_01_06_425581 265 22 include include VB 10_1101-2021_01_06_425581 265 23 explicitly explicitly RB 10_1101-2021_01_06_425581 265 24 spatial spatial JJ 10_1101-2021_01_06_425581 265 25 phenomena phenomenon NNS 10_1101-2021_01_06_425581 265 26 . . . 10_1101-2021_01_06_425581 266 1 Acknowledgements acknowledgement NNS 10_1101-2021_01_06_425581 266 2 We -PRON- PRP 10_1101-2021_01_06_425581 266 3 would would MD 10_1101-2021_01_06_425581 266 4 like like VB 10_1101-2021_01_06_425581 266 5 to to TO 10_1101-2021_01_06_425581 266 6 thank thank VB 10_1101-2021_01_06_425581 266 7 members member NNS 10_1101-2021_01_06_425581 266 8 of of IN 10_1101-2021_01_06_425581 266 9 the the DT 10_1101-2021_01_06_425581 266 10 DevoWorm DevoWorm NNP 10_1101-2021_01_06_425581 266 11 group group NN 10_1101-2021_01_06_425581 266 12 for for IN 10_1101-2021_01_06_425581 266 13 their -PRON- PRP$ 10_1101-2021_01_06_425581 266 14 support support NN 10_1101-2021_01_06_425581 266 15 and and CC 10_1101-2021_01_06_425581 266 16 feedback feedback NN 10_1101-2021_01_06_425581 266 17 , , , 10_1101-2021_01_06_425581 266 18 particularly particularly RB 10_1101-2021_01_06_425581 266 19 Susan Susan NNP 10_1101-2021_01_06_425581 266 20 Crawford Crawford NNP 10_1101-2021_01_06_425581 266 21 - - HYPH 10_1101-2021_01_06_425581 266 22 Young Young NNP 10_1101-2021_01_06_425581 266 23 . . . 10_1101-2021_01_06_425581 267 1 Thanks thank NNS 10_1101-2021_01_06_425581 267 2 also also RB 10_1101-2021_01_06_425581 267 3 go go VBP 10_1101-2021_01_06_425581 267 4 to to IN 10_1101-2021_01_06_425581 267 5 the the DT 10_1101-2021_01_06_425581 267 6 OpenWorm OpenWorm NNP 10_1101-2021_01_06_425581 267 7 Foundation Foundation NNP 10_1101-2021_01_06_425581 267 8 for for IN 10_1101-2021_01_06_425581 267 9 their -PRON- PRP$ 10_1101-2021_01_06_425581 267 10 institutional institutional JJ 10_1101-2021_01_06_425581 267 11 support support NN 10_1101-2021_01_06_425581 267 12 . . . 10_1101-2021_01_06_425581 268 1 Supplemental supplemental JJ 10_1101-2021_01_06_425581 268 2 Figures figure NNS 10_1101-2021_01_06_425581 268 3 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 268 4 Figure Figure NNP 10_1101-2021_01_06_425581 268 5 1 1 CD 10_1101-2021_01_06_425581 268 6 . . . 10_1101-2021_01_06_425581 269 1 Example example NN 10_1101-2021_01_06_425581 269 2 of of IN 10_1101-2021_01_06_425581 269 3 an an DT 10_1101-2021_01_06_425581 269 4 embryo embryo NN 10_1101-2021_01_06_425581 269 5 network network NN 10_1101-2021_01_06_425581 269 6 from from IN 10_1101-2021_01_06_425581 269 7 the the DT 10_1101-2021_01_06_425581 269 8 16-cell 16-cell CD 10_1101-2021_01_06_425581 269 9 ​C. ​C. NNS 10_1101-2021_01_06_425581 270 1 elegans elegans NNPS 10_1101-2021_01_06_425581 270 2 embryo embryo VBD 10_1101-2021_01_06_425581 270 3 build build NN 10_1101-2021_01_06_425581 270 4 using use VBG 10_1101-2021_01_06_425581 270 5 cell cell NN 10_1101-2021_01_06_425581 270 6 tracking tracking NN 10_1101-2021_01_06_425581 270 7 data datum NNS 10_1101-2021_01_06_425581 270 8 . . . 10_1101-2021_01_06_425581 271 1 Data datum NNS 10_1101-2021_01_06_425581 271 2 shown show VBN 10_1101-2021_01_06_425581 271 3 in in IN 10_1101-2021_01_06_425581 271 4 the the DT 10_1101-2021_01_06_425581 271 5 context context NN 10_1101-2021_01_06_425581 271 6 of of IN 10_1101-2021_01_06_425581 271 7 a a DT 10_1101-2021_01_06_425581 271 8 cartoon cartoon NN 10_1101-2021_01_06_425581 271 9 showing show VBG 10_1101-2021_01_06_425581 271 10 the the DT 10_1101-2021_01_06_425581 271 11 anterior anterior JJ 10_1101-2021_01_06_425581 271 12 end end NN 10_1101-2021_01_06_425581 271 13 of of IN 10_1101-2021_01_06_425581 271 14 the the DT 10_1101-2021_01_06_425581 271 15 embryo embryo NN 10_1101-2021_01_06_425581 271 16 . . . 10_1101-2021_01_06_425581 272 1 Different different JJ 10_1101-2021_01_06_425581 272 2 colored colored JJ 10_1101-2021_01_06_425581 272 3 edges edge NNS 10_1101-2021_01_06_425581 272 4 represent represent VBP 10_1101-2021_01_06_425581 272 5 cells cell NNS 10_1101-2021_01_06_425581 272 6 born bear VBN 10_1101-2021_01_06_425581 272 7 at at IN 10_1101-2021_01_06_425581 272 8 different different JJ 10_1101-2021_01_06_425581 272 9 generations generation NNS 10_1101-2021_01_06_425581 272 10 of of IN 10_1101-2021_01_06_425581 272 11 the the DT 10_1101-2021_01_06_425581 272 12 lineage lineage NN 10_1101-2021_01_06_425581 272 13 tree tree NN 10_1101-2021_01_06_425581 272 14 ( ( -LRB- 10_1101-2021_01_06_425581 272 15 levels level NNS 10_1101-2021_01_06_425581 272 16 ) ) -RRB- 10_1101-2021_01_06_425581 272 17 . . . 10_1101-2021_01_06_425581 273 1 13 13 CD 10_1101-2021_01_06_425581 273 2 .CC .CC : 10_1101-2021_01_06_425581 273 3 - - HYPH 10_1101-2021_01_06_425581 273 4 BY BY NNP 10_1101-2021_01_06_425581 273 5 - - HYPH 10_1101-2021_01_06_425581 273 6 NC NC NNP 10_1101-2021_01_06_425581 273 7 4.0 4.0 CD 10_1101-2021_01_06_425581 273 8 International international JJ 10_1101-2021_01_06_425581 273 9 licensemade licensemade NN 10_1101-2021_01_06_425581 273 10 available available JJ 10_1101-2021_01_06_425581 273 11 under under IN 10_1101-2021_01_06_425581 273 12 a a DT 10_1101-2021_01_06_425581 273 13 ( ( -LRB- 10_1101-2021_01_06_425581 273 14 which which WDT 10_1101-2021_01_06_425581 273 15 was be VBD 10_1101-2021_01_06_425581 273 16 not not RB 10_1101-2021_01_06_425581 273 17 certified certify VBN 10_1101-2021_01_06_425581 273 18 by by IN 10_1101-2021_01_06_425581 273 19 peer peer NN 10_1101-2021_01_06_425581 273 20 review review NN 10_1101-2021_01_06_425581 273 21 ) ) -RRB- 10_1101-2021_01_06_425581 273 22 is be VBZ 10_1101-2021_01_06_425581 273 23 the the DT 10_1101-2021_01_06_425581 273 24 author author NN 10_1101-2021_01_06_425581 273 25 / / SYM 10_1101-2021_01_06_425581 273 26 funder funder NN 10_1101-2021_01_06_425581 273 27 , , , 10_1101-2021_01_06_425581 273 28 who who WP 10_1101-2021_01_06_425581 273 29 has have VBZ 10_1101-2021_01_06_425581 273 30 granted grant VBN 10_1101-2021_01_06_425581 273 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 273 32 a a DT 10_1101-2021_01_06_425581 273 33 license license NN 10_1101-2021_01_06_425581 273 34 to to TO 10_1101-2021_01_06_425581 273 35 display display VB 10_1101-2021_01_06_425581 273 36 the the DT 10_1101-2021_01_06_425581 273 37 preprint preprint NN 10_1101-2021_01_06_425581 273 38 in in IN 10_1101-2021_01_06_425581 273 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 273 40 . . . 10_1101-2021_01_06_425581 274 1 It -PRON- PRP 10_1101-2021_01_06_425581 274 2 is be VBZ 10_1101-2021_01_06_425581 274 3 The the DT 10_1101-2021_01_06_425581 274 4 copyright copyright NN 10_1101-2021_01_06_425581 274 5 holder holder NN 10_1101-2021_01_06_425581 274 6 for for IN 10_1101-2021_01_06_425581 274 7 this this DT 10_1101-2021_01_06_425581 274 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 274 9 version version NN 10_1101-2021_01_06_425581 274 10 posted post VBD 10_1101-2021_01_06_425581 274 11 January January NNP 10_1101-2021_01_06_425581 274 12 8 8 CD 10_1101-2021_01_06_425581 274 13 , , , 10_1101-2021_01_06_425581 274 14 2021 2021 CD 10_1101-2021_01_06_425581 274 15 . . . 10_1101-2021_01_06_425581 274 16 ; ; : 10_1101-2021_01_06_425581 274 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 274 18 : : : 10_1101-2021_01_06_425581 274 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 274 20 preprint preprint NN 10_1101-2021_01_06_425581 274 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 274 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 274 23 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 274 24 Figure Figure NNP 10_1101-2021_01_06_425581 274 25 2 2 CD 10_1101-2021_01_06_425581 274 26 . . . 10_1101-2021_01_06_425581 275 1 Frequency frequency NN 10_1101-2021_01_06_425581 275 2 - - HYPH 10_1101-2021_01_06_425581 275 3 domain domain NN 10_1101-2021_01_06_425581 275 4 plot plot NN 10_1101-2021_01_06_425581 275 5 of of IN 10_1101-2021_01_06_425581 275 6 cell cell NN 10_1101-2021_01_06_425581 275 7 division division NN 10_1101-2021_01_06_425581 275 8 event event NN 10_1101-2021_01_06_425581 275 9 frequencies frequency NNS 10_1101-2021_01_06_425581 275 10 in in IN 10_1101-2021_01_06_425581 275 11 C. C. NNP 10_1101-2021_01_06_425581 275 12 elegans elegan NNS 10_1101-2021_01_06_425581 275 13 embryo embryo VBD 10_1101-2021_01_06_425581 275 14 . . . 10_1101-2021_01_06_425581 276 1 All all DT 10_1101-2021_01_06_425581 276 2 events event NNS 10_1101-2021_01_06_425581 276 3 greater great JJR 10_1101-2021_01_06_425581 276 4 than than IN 10_1101-2021_01_06_425581 276 5 an an DT 10_1101-2021_01_06_425581 276 6 amplitude amplitude NN 10_1101-2021_01_06_425581 276 7 of of IN 10_1101-2021_01_06_425581 276 8 200 200 CD 10_1101-2021_01_06_425581 276 9 shown show VBN 10_1101-2021_01_06_425581 276 10 in in IN 10_1101-2021_01_06_425581 276 11 red red NN 10_1101-2021_01_06_425581 276 12 , , , 10_1101-2021_01_06_425581 276 13 while while IN 10_1101-2021_01_06_425581 276 14 all all DT 10_1101-2021_01_06_425581 276 15 events event NNS 10_1101-2021_01_06_425581 276 16 greater great JJR 10_1101-2021_01_06_425581 276 17 than than IN 10_1101-2021_01_06_425581 276 18 an an DT 10_1101-2021_01_06_425581 276 19 amplitude amplitude NN 10_1101-2021_01_06_425581 276 20 of of IN 10_1101-2021_01_06_425581 276 21 800 800 CD 10_1101-2021_01_06_425581 276 22 shown show VBN 10_1101-2021_01_06_425581 276 23 in in IN 10_1101-2021_01_06_425581 276 24 blue blue NNP 10_1101-2021_01_06_425581 276 25 . . . 10_1101-2021_01_06_425581 277 1 Supplemental supplemental JJ 10_1101-2021_01_06_425581 277 2 Figure Figure NNP 10_1101-2021_01_06_425581 277 3 3 3 CD 10_1101-2021_01_06_425581 277 4 . . . 10_1101-2021_01_06_425581 278 1 Frequency frequency NN 10_1101-2021_01_06_425581 278 2 - - HYPH 10_1101-2021_01_06_425581 278 3 domain domain NN 10_1101-2021_01_06_425581 278 4 plot plot NN 10_1101-2021_01_06_425581 278 5 of of IN 10_1101-2021_01_06_425581 278 6 cell cell NN 10_1101-2021_01_06_425581 278 7 differentiation differentiation NN 10_1101-2021_01_06_425581 278 8 event event NN 10_1101-2021_01_06_425581 278 9 frequencies frequency NNS 10_1101-2021_01_06_425581 278 10 in in IN 10_1101-2021_01_06_425581 278 11 ​C. ​c. ADD 10_1101-2021_01_06_425581 279 1 elegans elegans NNPS 10_1101-2021_01_06_425581 279 2 embryo embryo VBD 10_1101-2021_01_06_425581 279 3 . . . 10_1101-2021_01_06_425581 280 1 All all DT 10_1101-2021_01_06_425581 280 2 events event NNS 10_1101-2021_01_06_425581 280 3 greater great JJR 10_1101-2021_01_06_425581 280 4 than than IN 10_1101-2021_01_06_425581 280 5 an an DT 10_1101-2021_01_06_425581 280 6 amplitude amplitude NN 10_1101-2021_01_06_425581 280 7 of of IN 10_1101-2021_01_06_425581 280 8 300 300 CD 10_1101-2021_01_06_425581 280 9 shown show VBN 10_1101-2021_01_06_425581 280 10 in in IN 10_1101-2021_01_06_425581 280 11 red red NN 10_1101-2021_01_06_425581 280 12 , , , 10_1101-2021_01_06_425581 280 13 while while IN 10_1101-2021_01_06_425581 280 14 all all DT 10_1101-2021_01_06_425581 280 15 events event NNS 10_1101-2021_01_06_425581 280 16 greater great JJR 10_1101-2021_01_06_425581 280 17 than than IN 10_1101-2021_01_06_425581 280 18 an an DT 10_1101-2021_01_06_425581 280 19 amplitude amplitude NN 10_1101-2021_01_06_425581 280 20 of of IN 10_1101-2021_01_06_425581 280 21 600 600 CD 10_1101-2021_01_06_425581 280 22 shown show VBN 10_1101-2021_01_06_425581 280 23 in in IN 10_1101-2021_01_06_425581 280 24 blue blue NNP 10_1101-2021_01_06_425581 280 25 . . . 10_1101-2021_01_06_425581 281 1 14 14 CD 10_1101-2021_01_06_425581 281 2 .CC .CC : 10_1101-2021_01_06_425581 281 3 - - HYPH 10_1101-2021_01_06_425581 281 4 BY BY NNP 10_1101-2021_01_06_425581 281 5 - - HYPH 10_1101-2021_01_06_425581 281 6 NC NC NNP 10_1101-2021_01_06_425581 281 7 4.0 4.0 CD 10_1101-2021_01_06_425581 281 8 International international JJ 10_1101-2021_01_06_425581 281 9 licensemade licensemade NN 10_1101-2021_01_06_425581 281 10 available available JJ 10_1101-2021_01_06_425581 281 11 under under IN 10_1101-2021_01_06_425581 281 12 a a DT 10_1101-2021_01_06_425581 281 13 ( ( -LRB- 10_1101-2021_01_06_425581 281 14 which which WDT 10_1101-2021_01_06_425581 281 15 was be VBD 10_1101-2021_01_06_425581 281 16 not not RB 10_1101-2021_01_06_425581 281 17 certified certify VBN 10_1101-2021_01_06_425581 281 18 by by IN 10_1101-2021_01_06_425581 281 19 peer peer NN 10_1101-2021_01_06_425581 281 20 review review NN 10_1101-2021_01_06_425581 281 21 ) ) -RRB- 10_1101-2021_01_06_425581 281 22 is be VBZ 10_1101-2021_01_06_425581 281 23 the the DT 10_1101-2021_01_06_425581 281 24 author author NN 10_1101-2021_01_06_425581 281 25 / / SYM 10_1101-2021_01_06_425581 281 26 funder funder NN 10_1101-2021_01_06_425581 281 27 , , , 10_1101-2021_01_06_425581 281 28 who who WP 10_1101-2021_01_06_425581 281 29 has have VBZ 10_1101-2021_01_06_425581 281 30 granted grant VBN 10_1101-2021_01_06_425581 281 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 281 32 a a DT 10_1101-2021_01_06_425581 281 33 license license NN 10_1101-2021_01_06_425581 281 34 to to TO 10_1101-2021_01_06_425581 281 35 display display VB 10_1101-2021_01_06_425581 281 36 the the DT 10_1101-2021_01_06_425581 281 37 preprint preprint NN 10_1101-2021_01_06_425581 281 38 in in IN 10_1101-2021_01_06_425581 281 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 281 40 . . . 10_1101-2021_01_06_425581 282 1 It -PRON- PRP 10_1101-2021_01_06_425581 282 2 is be VBZ 10_1101-2021_01_06_425581 282 3 The the DT 10_1101-2021_01_06_425581 282 4 copyright copyright NN 10_1101-2021_01_06_425581 282 5 holder holder NN 10_1101-2021_01_06_425581 282 6 for for IN 10_1101-2021_01_06_425581 282 7 this this DT 10_1101-2021_01_06_425581 282 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 282 9 version version NN 10_1101-2021_01_06_425581 282 10 posted post VBD 10_1101-2021_01_06_425581 282 11 January January NNP 10_1101-2021_01_06_425581 282 12 8 8 CD 10_1101-2021_01_06_425581 282 13 , , , 10_1101-2021_01_06_425581 282 14 2021 2021 CD 10_1101-2021_01_06_425581 282 15 . . . 10_1101-2021_01_06_425581 282 16 ; ; : 10_1101-2021_01_06_425581 282 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 282 18 : : : 10_1101-2021_01_06_425581 282 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 282 20 preprint preprint NN 10_1101-2021_01_06_425581 282 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 282 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 282 23 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 282 24 Figure Figure NNP 10_1101-2021_01_06_425581 282 25 4 4 CD 10_1101-2021_01_06_425581 282 26 . . . 10_1101-2021_01_06_425581 283 1 Frequency frequency NN 10_1101-2021_01_06_425581 283 2 - - HYPH 10_1101-2021_01_06_425581 283 3 domain domain NN 10_1101-2021_01_06_425581 283 4 plot plot NN 10_1101-2021_01_06_425581 283 5 of of IN 10_1101-2021_01_06_425581 283 6 cell cell NN 10_1101-2021_01_06_425581 283 7 division division NN 10_1101-2021_01_06_425581 283 8 event event NN 10_1101-2021_01_06_425581 283 9 frequencies frequency NNS 10_1101-2021_01_06_425581 283 10 in in IN 10_1101-2021_01_06_425581 283 11 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 283 12 embryo embryo NN 10_1101-2021_01_06_425581 283 13 . . . 10_1101-2021_01_06_425581 284 1 Supplemental Supplemental NNP 10_1101-2021_01_06_425581 284 2 Figure Figure NNP 10_1101-2021_01_06_425581 284 3 5 5 CD 10_1101-2021_01_06_425581 284 4 . . . 10_1101-2021_01_06_425581 285 1 Comparison comparison NN 10_1101-2021_01_06_425581 285 2 of of IN 10_1101-2021_01_06_425581 285 3 cumulative cumulative JJ 10_1101-2021_01_06_425581 285 4 cell cell NN 10_1101-2021_01_06_425581 285 5 division division NN 10_1101-2021_01_06_425581 285 6 events event NNS 10_1101-2021_01_06_425581 285 7 and and CC 10_1101-2021_01_06_425581 285 8 the the DT 10_1101-2021_01_06_425581 285 9 speed speed NN 10_1101-2021_01_06_425581 285 10 of of IN 10_1101-2021_01_06_425581 285 11 division division NN 10_1101-2021_01_06_425581 285 12 generated generate VBN 10_1101-2021_01_06_425581 285 13 by by IN 10_1101-2021_01_06_425581 285 14 a a DT 10_1101-2021_01_06_425581 285 15 numeric numeric JJ 10_1101-2021_01_06_425581 285 16 embryo embryo NN 10_1101-2021_01_06_425581 285 17 for for IN 10_1101-2021_01_06_425581 285 18 the the DT 10_1101-2021_01_06_425581 285 19 Poisson Poisson NNP 10_1101-2021_01_06_425581 285 20 distribution distribution NN 10_1101-2021_01_06_425581 285 21 at at IN 10_1101-2021_01_06_425581 285 22 three three CD 10_1101-2021_01_06_425581 285 23 different different JJ 10_1101-2021_01_06_425581 285 24 values value NNS 10_1101-2021_01_06_425581 285 25 of of IN 10_1101-2021_01_06_425581 285 26 λ λ PRP 10_1101-2021_01_06_425581 285 27 . . . 10_1101-2021_01_06_425581 286 1 Blue Blue NNP 10_1101-2021_01_06_425581 286 2 : : : 10_1101-2021_01_06_425581 286 3 λ λ NN 10_1101-2021_01_06_425581 286 4 = = SYM 10_1101-2021_01_06_425581 286 5 0.1 0.1 CD 10_1101-2021_01_06_425581 286 6 , , , 10_1101-2021_01_06_425581 286 7 Black Black NNP 10_1101-2021_01_06_425581 286 8 : : : 10_1101-2021_01_06_425581 286 9 λ λ NNP 10_1101-2021_01_06_425581 286 10 = = SYM 10_1101-2021_01_06_425581 286 11 0.5 0.5 CD 10_1101-2021_01_06_425581 286 12 , , , 10_1101-2021_01_06_425581 286 13 Red red NN 10_1101-2021_01_06_425581 286 14 : : : 10_1101-2021_01_06_425581 286 15 λ λ NN 10_1101-2021_01_06_425581 286 16 = = SYM 10_1101-2021_01_06_425581 286 17 1.0 1.0 CD 10_1101-2021_01_06_425581 286 18 . . . 10_1101-2021_01_06_425581 287 1 15 15 CD 10_1101-2021_01_06_425581 287 2 .CC .CC : 10_1101-2021_01_06_425581 287 3 - - HYPH 10_1101-2021_01_06_425581 287 4 BY BY NNP 10_1101-2021_01_06_425581 287 5 - - HYPH 10_1101-2021_01_06_425581 287 6 NC NC NNP 10_1101-2021_01_06_425581 287 7 4.0 4.0 CD 10_1101-2021_01_06_425581 287 8 International international JJ 10_1101-2021_01_06_425581 287 9 licensemade licensemade NN 10_1101-2021_01_06_425581 287 10 available available JJ 10_1101-2021_01_06_425581 287 11 under under IN 10_1101-2021_01_06_425581 287 12 a a DT 10_1101-2021_01_06_425581 287 13 ( ( -LRB- 10_1101-2021_01_06_425581 287 14 which which WDT 10_1101-2021_01_06_425581 287 15 was be VBD 10_1101-2021_01_06_425581 287 16 not not RB 10_1101-2021_01_06_425581 287 17 certified certify VBN 10_1101-2021_01_06_425581 287 18 by by IN 10_1101-2021_01_06_425581 287 19 peer peer NN 10_1101-2021_01_06_425581 287 20 review review NN 10_1101-2021_01_06_425581 287 21 ) ) -RRB- 10_1101-2021_01_06_425581 287 22 is be VBZ 10_1101-2021_01_06_425581 287 23 the the DT 10_1101-2021_01_06_425581 287 24 author author NN 10_1101-2021_01_06_425581 287 25 / / SYM 10_1101-2021_01_06_425581 287 26 funder funder NN 10_1101-2021_01_06_425581 287 27 , , , 10_1101-2021_01_06_425581 287 28 who who WP 10_1101-2021_01_06_425581 287 29 has have VBZ 10_1101-2021_01_06_425581 287 30 granted grant VBN 10_1101-2021_01_06_425581 287 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 287 32 a a DT 10_1101-2021_01_06_425581 287 33 license license NN 10_1101-2021_01_06_425581 287 34 to to TO 10_1101-2021_01_06_425581 287 35 display display VB 10_1101-2021_01_06_425581 287 36 the the DT 10_1101-2021_01_06_425581 287 37 preprint preprint NN 10_1101-2021_01_06_425581 287 38 in in IN 10_1101-2021_01_06_425581 287 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 287 40 . . . 10_1101-2021_01_06_425581 288 1 It -PRON- PRP 10_1101-2021_01_06_425581 288 2 is be VBZ 10_1101-2021_01_06_425581 288 3 The the DT 10_1101-2021_01_06_425581 288 4 copyright copyright NN 10_1101-2021_01_06_425581 288 5 holder holder NN 10_1101-2021_01_06_425581 288 6 for for IN 10_1101-2021_01_06_425581 288 7 this this DT 10_1101-2021_01_06_425581 288 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 288 9 version version NN 10_1101-2021_01_06_425581 288 10 posted post VBD 10_1101-2021_01_06_425581 288 11 January January NNP 10_1101-2021_01_06_425581 288 12 8 8 CD 10_1101-2021_01_06_425581 288 13 , , , 10_1101-2021_01_06_425581 288 14 2021 2021 CD 10_1101-2021_01_06_425581 288 15 . . . 10_1101-2021_01_06_425581 288 16 ; ; : 10_1101-2021_01_06_425581 288 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 288 18 : : : 10_1101-2021_01_06_425581 288 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 288 20 preprint preprint NN 10_1101-2021_01_06_425581 288 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 288 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 288 23 References References NNP 10_1101-2021_01_06_425581 288 24 [ [ -LRB- 10_1101-2021_01_06_425581 288 25 1 1 CD 10_1101-2021_01_06_425581 288 26 ] ] -RRB- 10_1101-2021_01_06_425581 288 27 Simpson Simpson NNP 10_1101-2021_01_06_425581 288 28 , , , 10_1101-2021_01_06_425581 288 29 G.G. G.G. NNP 10_1101-2021_01_06_425581 289 1 ( ( -LRB- 10_1101-2021_01_06_425581 289 2 1944 1944 CD 10_1101-2021_01_06_425581 289 3 ) ) -RRB- 10_1101-2021_01_06_425581 289 4 . . . 10_1101-2021_01_06_425581 290 1 Tempo Tempo NNP 10_1101-2021_01_06_425581 290 2 and and CC 10_1101-2021_01_06_425581 290 3 Mode Mode NNP 10_1101-2021_01_06_425581 290 4 in in IN 10_1101-2021_01_06_425581 290 5 Evolution Evolution NNP 10_1101-2021_01_06_425581 290 6 . . . 10_1101-2021_01_06_425581 291 1 Columbia Columbia NNP 10_1101-2021_01_06_425581 291 2 University University NNP 10_1101-2021_01_06_425581 291 3 Press Press NNP 10_1101-2021_01_06_425581 291 4 , , , 10_1101-2021_01_06_425581 291 5 New New NNP 10_1101-2021_01_06_425581 291 6 York York NNP 10_1101-2021_01_06_425581 291 7 . . . 10_1101-2021_01_06_425581 292 1 [ [ -LRB- 10_1101-2021_01_06_425581 292 2 2 2 LS 10_1101-2021_01_06_425581 292 3 ] ] -RRB- 10_1101-2021_01_06_425581 292 4 Ogura Ogura NNP 10_1101-2021_01_06_425581 292 5 , , , 10_1101-2021_01_06_425581 292 6 Y. Y. NNP 10_1101-2021_01_06_425581 293 1 & & CC 10_1101-2021_01_06_425581 293 2 Sasakura Sasakura NNP 10_1101-2021_01_06_425581 293 3 , , , 10_1101-2021_01_06_425581 293 4 Y. Y. NNP 10_1101-2021_01_06_425581 294 1 ( ( -LRB- 10_1101-2021_01_06_425581 294 2 2016 2016 CD 10_1101-2021_01_06_425581 294 3 ) ) -RRB- 10_1101-2021_01_06_425581 294 4 . . . 10_1101-2021_01_06_425581 295 1 Developmental developmental JJ 10_1101-2021_01_06_425581 295 2 Control Control NNP 10_1101-2021_01_06_425581 295 3 of of IN 10_1101-2021_01_06_425581 295 4 Cell Cell NNP 10_1101-2021_01_06_425581 295 5 - - HYPH 10_1101-2021_01_06_425581 295 6 Cycle Cycle NNP 10_1101-2021_01_06_425581 295 7 Compensation Compensation NNP 10_1101-2021_01_06_425581 295 8 Provides provide VBZ 10_1101-2021_01_06_425581 295 9 a a DT 10_1101-2021_01_06_425581 295 10 Switch Switch NNP 10_1101-2021_01_06_425581 295 11 for for IN 10_1101-2021_01_06_425581 295 12 Patterned Patterned NNP 10_1101-2021_01_06_425581 295 13 Mitosis Mitosis NNP 10_1101-2021_01_06_425581 295 14 at at IN 10_1101-2021_01_06_425581 295 15 the the DT 10_1101-2021_01_06_425581 295 16 Onset Onset NNP 10_1101-2021_01_06_425581 295 17 of of IN 10_1101-2021_01_06_425581 295 18 Chordate Chordate NNP 10_1101-2021_01_06_425581 295 19 Neurulation Neurulation NNP 10_1101-2021_01_06_425581 295 20 . . . 10_1101-2021_01_06_425581 296 1 ​Developmental ​Developmental NNP 10_1101-2021_01_06_425581 296 2 Cell​ Cell​ NNP 10_1101-2021_01_06_425581 296 3 , , , 10_1101-2021_01_06_425581 296 4 37(2 37(2 CD 10_1101-2021_01_06_425581 296 5 ) ) -RRB- 10_1101-2021_01_06_425581 296 6 , , , 10_1101-2021_01_06_425581 296 7 P148 P148 NNP 10_1101-2021_01_06_425581 296 8 - - HYPH 10_1101-2021_01_06_425581 296 9 161 161 CD 10_1101-2021_01_06_425581 296 10 . . . 10_1101-2021_01_06_425581 297 1 doi:10.1016 doi:10.1016 NNP 10_1101-2021_01_06_425581 297 2 / / SYM 10_1101-2021_01_06_425581 297 3 j.devcel.2016.03.013 j.devcel.2016.03.013 NNP 10_1101-2021_01_06_425581 297 4 [ [ -LRB- 10_1101-2021_01_06_425581 297 5 3 3 CD 10_1101-2021_01_06_425581 297 6 ] ] -RRB- 10_1101-2021_01_06_425581 297 7 Bhatla Bhatla NNP 10_1101-2021_01_06_425581 297 8 , , , 10_1101-2021_01_06_425581 297 9 N. N. NNP 10_1101-2021_01_06_425581 297 10 ( ( -LRB- 10_1101-2021_01_06_425581 297 11 2011 2011 CD 10_1101-2021_01_06_425581 297 12 ) ) -RRB- 10_1101-2021_01_06_425581 297 13 . . . 10_1101-2021_01_06_425581 298 1 An an DT 10_1101-2021_01_06_425581 298 2 Interactive interactive JJ 10_1101-2021_01_06_425581 298 3 Visualization Visualization NNP 10_1101-2021_01_06_425581 298 4 of of IN 10_1101-2021_01_06_425581 298 5 the the DT 10_1101-2021_01_06_425581 298 6 ​C. ​C. NNS 10_1101-2021_01_06_425581 299 1 elegans elegans NNPS 10_1101-2021_01_06_425581 299 2 Cell Cell NNP 10_1101-2021_01_06_425581 299 3 Lineage Lineage NNP 10_1101-2021_01_06_425581 299 4 . . . 10_1101-2021_01_06_425581 300 1 WormWeb WormWeb NNP 10_1101-2021_01_06_425581 300 2 ​ ​ NNP 10_1101-2021_01_06_425581 300 3 , , , 10_1101-2021_01_06_425581 300 4 wormweb.org/celllineage wormweb.org/celllineage NNP 10_1101-2021_01_06_425581 300 5 [ [ -LRB- 10_1101-2021_01_06_425581 300 6 4 4 CD 10_1101-2021_01_06_425581 300 7 ] ] -RRB- 10_1101-2021_01_06_425581 300 8 Keller Keller NNP 10_1101-2021_01_06_425581 300 9 . . . 10_1101-2021_01_06_425581 301 1 P.J. P.J. NNP 10_1101-2021_01_06_425581 301 2 , , , 10_1101-2021_01_06_425581 301 3 Schmidt Schmidt NNP 10_1101-2021_01_06_425581 301 4 , , , 10_1101-2021_01_06_425581 301 5 A.D. A.D. NNP 10_1101-2021_01_06_425581 301 6 , , , 10_1101-2021_01_06_425581 301 7 Wittbrodt Wittbrodt NNP 10_1101-2021_01_06_425581 301 8 , , , 10_1101-2021_01_06_425581 301 9 J. J. NNP 10_1101-2021_01_06_425581 301 10 , , , 10_1101-2021_01_06_425581 301 11 & & CC 10_1101-2021_01_06_425581 301 12 Stelzer Stelzer NNP 10_1101-2021_01_06_425581 301 13 , , , 10_1101-2021_01_06_425581 301 14 E.H.K. E.H.K. NNP 10_1101-2021_01_06_425581 302 1 ( ( -LRB- 10_1101-2021_01_06_425581 302 2 2008 2008 CD 10_1101-2021_01_06_425581 302 3 ) ) -RRB- 10_1101-2021_01_06_425581 302 4 . . . 10_1101-2021_01_06_425581 303 1 Reconstruction reconstruction NN 10_1101-2021_01_06_425581 303 2 of of IN 10_1101-2021_01_06_425581 303 3 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 303 4 Early Early NNP 10_1101-2021_01_06_425581 303 5 Embryonic Embryonic NNP 10_1101-2021_01_06_425581 303 6 Development Development NNP 10_1101-2021_01_06_425581 303 7 by by IN 10_1101-2021_01_06_425581 303 8 Scanned Scanned NNP 10_1101-2021_01_06_425581 303 9 Light Light NNP 10_1101-2021_01_06_425581 303 10 Sheet Sheet NNP 10_1101-2021_01_06_425581 303 11 Microscopy Microscopy NNP 10_1101-2021_01_06_425581 303 12 . . . 10_1101-2021_01_06_425581 304 1 ​Science ​Science NNP 10_1101-2021_01_06_425581 304 2 ​ ​ NNP 10_1101-2021_01_06_425581 304 3 , , , 10_1101-2021_01_06_425581 304 4 322(5904 322(5904 NNP 10_1101-2021_01_06_425581 304 5 ) ) -RRB- 10_1101-2021_01_06_425581 304 6 , , , 10_1101-2021_01_06_425581 304 7 1065 1065 CD 10_1101-2021_01_06_425581 304 8 - - SYM 10_1101-2021_01_06_425581 304 9 1069 1069 CD 10_1101-2021_01_06_425581 304 10 . . . 10_1101-2021_01_06_425581 304 11 doi:10.1126 doi:10.1126 NNP 10_1101-2021_01_06_425581 304 12 / / SYM 10_1101-2021_01_06_425581 304 13 science.1162493 science.1162493 NN 10_1101-2021_01_06_425581 304 14 . . . 10_1101-2021_01_06_425581 305 1 [ [ -LRB- 10_1101-2021_01_06_425581 305 2 5 5 LS 10_1101-2021_01_06_425581 305 3 ] ] -RRB- 10_1101-2021_01_06_425581 305 4 Barabasi Barabasi NNP 10_1101-2021_01_06_425581 305 5 , , , 10_1101-2021_01_06_425581 305 6 A.L. A.L. NNP 10_1101-2021_01_06_425581 306 1 ( ( -LRB- 10_1101-2021_01_06_425581 306 2 2005 2005 CD 10_1101-2021_01_06_425581 306 3 ) ) -RRB- 10_1101-2021_01_06_425581 306 4 . . . 10_1101-2021_01_06_425581 307 1 The the DT 10_1101-2021_01_06_425581 307 2 origin origin NN 10_1101-2021_01_06_425581 307 3 of of IN 10_1101-2021_01_06_425581 307 4 bursts burst NNS 10_1101-2021_01_06_425581 307 5 and and CC 10_1101-2021_01_06_425581 307 6 heavy heavy JJ 10_1101-2021_01_06_425581 307 7 tails tail NNS 10_1101-2021_01_06_425581 307 8 in in IN 10_1101-2021_01_06_425581 307 9 human human JJ 10_1101-2021_01_06_425581 307 10 dynamics dynamic NNS 10_1101-2021_01_06_425581 307 11 . . . 10_1101-2021_01_06_425581 308 1 Nature Nature NNP 10_1101-2021_01_06_425581 308 2 ​ ​ NNP 10_1101-2021_01_06_425581 308 3 , , , 10_1101-2021_01_06_425581 308 4 435(7039 435(7039 CD 10_1101-2021_01_06_425581 308 5 ) ) -RRB- 10_1101-2021_01_06_425581 308 6 , , , 10_1101-2021_01_06_425581 308 7 207–211 207–211 CD 10_1101-2021_01_06_425581 308 8 . . . 10_1101-2021_01_06_425581 309 1 [ [ -LRB- 10_1101-2021_01_06_425581 309 2 6 6 CD 10_1101-2021_01_06_425581 309 3 ] ] -RRB- 10_1101-2021_01_06_425581 309 4 Abney Abney NNP 10_1101-2021_01_06_425581 309 5 , , , 10_1101-2021_01_06_425581 309 6 D.H. D.H. NNP 10_1101-2021_01_06_425581 309 7 , , , 10_1101-2021_01_06_425581 309 8 Dale Dale NNP 10_1101-2021_01_06_425581 309 9 , , , 10_1101-2021_01_06_425581 309 10 R. R. NNP 10_1101-2021_01_06_425581 309 11 , , , 10_1101-2021_01_06_425581 309 12 Louwerse Louwerse NNP 10_1101-2021_01_06_425581 309 13 , , , 10_1101-2021_01_06_425581 309 14 M.M. M.M. NNP 10_1101-2021_01_06_425581 309 15 , , , 10_1101-2021_01_06_425581 309 16 and and CC 10_1101-2021_01_06_425581 309 17 Kello Kello NNP 10_1101-2021_01_06_425581 309 18 , , , 10_1101-2021_01_06_425581 309 19 C.T. C.T. NNP 10_1101-2021_01_06_425581 310 1 ( ( -LRB- 10_1101-2021_01_06_425581 310 2 2018 2018 CD 10_1101-2021_01_06_425581 310 3 ) ) -RRB- 10_1101-2021_01_06_425581 310 4 . . . 10_1101-2021_01_06_425581 311 1 The the DT 10_1101-2021_01_06_425581 311 2 Bursts Bursts NNPS 10_1101-2021_01_06_425581 311 3 and and CC 10_1101-2021_01_06_425581 311 4 Lulls Lulls NNP 10_1101-2021_01_06_425581 311 5 of of IN 10_1101-2021_01_06_425581 311 6 Multimodal Multimodal NNP 10_1101-2021_01_06_425581 311 7 Interaction Interaction NNP 10_1101-2021_01_06_425581 311 8 . . . 10_1101-2021_01_06_425581 312 1 ​Cognitive ​cognitive JJ 10_1101-2021_01_06_425581 312 2 Science​ science​ NN 10_1101-2021_01_06_425581 312 3 , , , 10_1101-2021_01_06_425581 312 4 42(2 42(2 JJ 10_1101-2021_01_06_425581 312 5 ) ) -RRB- 10_1101-2021_01_06_425581 312 6 , , , 10_1101-2021_01_06_425581 312 7 1297 1297 CD 10_1101-2021_01_06_425581 312 8 - - SYM 10_1101-2021_01_06_425581 312 9 1316 1316 CD 10_1101-2021_01_06_425581 312 10 . . . 10_1101-2021_01_06_425581 313 1 [ [ -LRB- 10_1101-2021_01_06_425581 313 2 7 7 CD 10_1101-2021_01_06_425581 313 3 ] ] -RRB- 10_1101-2021_01_06_425581 313 4 Alicea Alicea NNP 10_1101-2021_01_06_425581 313 5 , , , 10_1101-2021_01_06_425581 313 6 B. B. NNP 10_1101-2021_01_06_425581 313 7 and and CC 10_1101-2021_01_06_425581 313 8 Gordon Gordon NNP 10_1101-2021_01_06_425581 313 9 R. R. NNP 10_1101-2021_01_06_425581 313 10 ( ( -LRB- 10_1101-2021_01_06_425581 313 11 2018 2018 CD 10_1101-2021_01_06_425581 313 12 ) ) -RRB- 10_1101-2021_01_06_425581 313 13 . . . 10_1101-2021_01_06_425581 314 1 Cell cell NN 10_1101-2021_01_06_425581 314 2 Differentiation differentiation NN 10_1101-2021_01_06_425581 314 3 Processes process VBZ 10_1101-2021_01_06_425581 314 4 as as IN 10_1101-2021_01_06_425581 314 5 Spatial Spatial NNP 10_1101-2021_01_06_425581 314 6 Networks Networks NNP 10_1101-2021_01_06_425581 314 7 : : : 10_1101-2021_01_06_425581 314 8 identifying identify VBG 10_1101-2021_01_06_425581 314 9 four four CD 10_1101-2021_01_06_425581 314 10 - - HYPH 10_1101-2021_01_06_425581 314 11 dimensional dimensional JJ 10_1101-2021_01_06_425581 314 12 structure structure NN 10_1101-2021_01_06_425581 314 13 in in IN 10_1101-2021_01_06_425581 314 14 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 314 15 . . . 10_1101-2021_01_06_425581 315 1 ​BioSystems​ ​BioSystems​ NNP 10_1101-2021_01_06_425581 315 2 , , , 10_1101-2021_01_06_425581 315 3 173 173 CD 10_1101-2021_01_06_425581 315 4 , , , 10_1101-2021_01_06_425581 315 5 235 235 CD 10_1101-2021_01_06_425581 315 6 - - SYM 10_1101-2021_01_06_425581 315 7 246 246 CD 10_1101-2021_01_06_425581 315 8 . . . 10_1101-2021_01_06_425581 316 1 [ [ -LRB- 10_1101-2021_01_06_425581 316 2 8 8 CD 10_1101-2021_01_06_425581 316 3 ] ] -RRB- 10_1101-2021_01_06_425581 316 4 Alicea Alicea NNP 10_1101-2021_01_06_425581 316 5 , , , 10_1101-2021_01_06_425581 316 6 B. B. NNP 10_1101-2021_01_06_425581 317 1 ( ( -LRB- 10_1101-2021_01_06_425581 317 2 2018 2018 CD 10_1101-2021_01_06_425581 317 3 ) ) -RRB- 10_1101-2021_01_06_425581 317 4 . . . 10_1101-2021_01_06_425581 318 1 The the DT 10_1101-2021_01_06_425581 318 2 Emergent Emergent NNP 10_1101-2021_01_06_425581 318 3 Connectome Connectome NNP 10_1101-2021_01_06_425581 318 4 in in IN 10_1101-2021_01_06_425581 318 5 ​Caenorhabditis ​caenorhabditis JJ 10_1101-2021_01_06_425581 318 6 elegans elegan NNS 10_1101-2021_01_06_425581 318 7 Embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 318 8 . . . 10_1101-2021_01_06_425581 319 1 ​BioSystems ​BioSystems NNP 10_1101-2021_01_06_425581 319 2 ​ ​ JJ 10_1101-2021_01_06_425581 319 3 , , , 10_1101-2021_01_06_425581 319 4 173 173 CD 10_1101-2021_01_06_425581 319 5 , , , 10_1101-2021_01_06_425581 319 6 247 247 CD 10_1101-2021_01_06_425581 319 7 - - HYPH 10_1101-2021_01_06_425581 319 8 255 255 CD 10_1101-2021_01_06_425581 319 9 . . . 10_1101-2021_01_06_425581 320 1 [ [ -LRB- 10_1101-2021_01_06_425581 320 2 9 9 CD 10_1101-2021_01_06_425581 320 3 ] ] -RRB- 10_1101-2021_01_06_425581 320 4 Alicea Alicea NNP 10_1101-2021_01_06_425581 320 5 , , , 10_1101-2021_01_06_425581 320 6 B. B. NNP 10_1101-2021_01_06_425581 321 1 ( ( -LRB- 10_1101-2021_01_06_425581 321 2 2020 2020 CD 10_1101-2021_01_06_425581 321 3 ) ) -RRB- 10_1101-2021_01_06_425581 321 4 . . . 10_1101-2021_01_06_425581 322 1 Raising raise VBG 10_1101-2021_01_06_425581 322 2 the the DT 10_1101-2021_01_06_425581 322 3 Connectome Connectome NNP 10_1101-2021_01_06_425581 322 4 : : : 10_1101-2021_01_06_425581 322 5 the the DT 10_1101-2021_01_06_425581 322 6 emergence emergence NN 10_1101-2021_01_06_425581 322 7 of of IN 10_1101-2021_01_06_425581 322 8 neuronal neuronal JJ 10_1101-2021_01_06_425581 322 9 activity activity NN 10_1101-2021_01_06_425581 322 10 and and CC 10_1101-2021_01_06_425581 322 11 behavior behavior NN 10_1101-2021_01_06_425581 322 12 in in IN 10_1101-2021_01_06_425581 322 13 ​C. ​c. ADD 10_1101-2021_01_06_425581 323 1 elegans elegans NNPS 10_1101-2021_01_06_425581 323 2 ​. ​. NNP 10_1101-2021_01_06_425581 324 1 ​Frontiers ​frontier NNS 10_1101-2021_01_06_425581 324 2 in in IN 10_1101-2021_01_06_425581 324 3 Cellular cellular JJ 10_1101-2021_01_06_425581 324 4 Neuroscience Neuroscience NNP 10_1101-2021_01_06_425581 324 5 ​ ​ NNP 10_1101-2021_01_06_425581 324 6 , , , 10_1101-2021_01_06_425581 324 7 doi:10.3389/ doi:10.3389/ JJ 10_1101-2021_01_06_425581 324 8 fncel.2020.524791 fncel.2020.524791 ADD 10_1101-2021_01_06_425581 324 9 . . . 10_1101-2021_01_06_425581 325 1 [ [ -LRB- 10_1101-2021_01_06_425581 325 2 10 10 CD 10_1101-2021_01_06_425581 325 3 ] ] -RRB- 10_1101-2021_01_06_425581 325 4 Foe Foe NNP 10_1101-2021_01_06_425581 325 5 , , , 10_1101-2021_01_06_425581 325 6 V.E. V.E. NNP 10_1101-2021_01_06_425581 326 1 & & CC 10_1101-2021_01_06_425581 326 2 Alberts Alberts NNPS 10_1101-2021_01_06_425581 326 3 , , , 10_1101-2021_01_06_425581 326 4 B.M. B.M. NNP 10_1101-2021_01_06_425581 327 1 ( ( -LRB- 10_1101-2021_01_06_425581 327 2 1983 1983 CD 10_1101-2021_01_06_425581 327 3 ) ) -RRB- 10_1101-2021_01_06_425581 327 4 . . . 10_1101-2021_01_06_425581 328 1 Studies study NNS 10_1101-2021_01_06_425581 328 2 of of IN 10_1101-2021_01_06_425581 328 3 nuclear nuclear JJ 10_1101-2021_01_06_425581 328 4 and and CC 10_1101-2021_01_06_425581 328 5 cytoplasmic cytoplasmic JJ 10_1101-2021_01_06_425581 328 6 behaviour behaviour NN 10_1101-2021_01_06_425581 328 7 during during IN 10_1101-2021_01_06_425581 328 8 the the DT 10_1101-2021_01_06_425581 328 9 five five CD 10_1101-2021_01_06_425581 328 10 mitotic mitotic JJ 10_1101-2021_01_06_425581 328 11 cycles cycle NNS 10_1101-2021_01_06_425581 328 12 that that WDT 10_1101-2021_01_06_425581 328 13 precede precede VBP 10_1101-2021_01_06_425581 328 14 gastrulation gastrulation NN 10_1101-2021_01_06_425581 328 15 in in IN 10_1101-2021_01_06_425581 328 16 ​Drosophila ​drosophila JJ 10_1101-2021_01_06_425581 328 17 embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 328 18 . . . 10_1101-2021_01_06_425581 329 1 Journal Journal NNP 10_1101-2021_01_06_425581 329 2 of of IN 10_1101-2021_01_06_425581 329 3 Cell Cell NNP 10_1101-2021_01_06_425581 329 4 Science Science NNP 10_1101-2021_01_06_425581 329 5 ​ ​ NNP 10_1101-2021_01_06_425581 329 6 , , , 10_1101-2021_01_06_425581 329 7 61 61 CD 10_1101-2021_01_06_425581 329 8 , , , 10_1101-2021_01_06_425581 329 9 31 31 CD 10_1101-2021_01_06_425581 329 10 - - SYM 10_1101-2021_01_06_425581 329 11 70 70 CD 10_1101-2021_01_06_425581 329 12 . . . 10_1101-2021_01_06_425581 330 1 [ [ -LRB- 10_1101-2021_01_06_425581 330 2 11 11 CD 10_1101-2021_01_06_425581 330 3 ] ] -RRB- 10_1101-2021_01_06_425581 330 4 Boterenbrood Boterenbrood NNP 10_1101-2021_01_06_425581 330 5 , , , 10_1101-2021_01_06_425581 330 6 E.C. E.C. NNP 10_1101-2021_01_06_425581 330 7 , , , 10_1101-2021_01_06_425581 330 8 Narraway Narraway NNP 10_1101-2021_01_06_425581 330 9 , , , 10_1101-2021_01_06_425581 330 10 J.M. J.M. NNP 10_1101-2021_01_06_425581 331 1 & & CC 10_1101-2021_01_06_425581 331 2 Hara Hara NNP 10_1101-2021_01_06_425581 331 3 , , , 10_1101-2021_01_06_425581 331 4 K. K. NNP 10_1101-2021_01_06_425581 331 5 ( ( -LRB- 10_1101-2021_01_06_425581 331 6 1983 1983 CD 10_1101-2021_01_06_425581 331 7 ) ) -RRB- 10_1101-2021_01_06_425581 331 8 Duration duration NN 10_1101-2021_01_06_425581 331 9 of of IN 10_1101-2021_01_06_425581 331 10 cleavage cleavage NN 10_1101-2021_01_06_425581 331 11 cycles cycle NNS 10_1101-2021_01_06_425581 331 12 and and CC 10_1101-2021_01_06_425581 331 13 asymmetry asymmetry NN 10_1101-2021_01_06_425581 331 14 in in IN 10_1101-2021_01_06_425581 331 15 the the DT 10_1101-2021_01_06_425581 331 16 direction direction NN 10_1101-2021_01_06_425581 331 17 of of IN 10_1101-2021_01_06_425581 331 18 cleavage cleavage NN 10_1101-2021_01_06_425581 331 19 waves wave NNS 10_1101-2021_01_06_425581 331 20 prior prior RB 10_1101-2021_01_06_425581 331 21 to to IN 10_1101-2021_01_06_425581 331 22 gastrulation gastrulation NN 10_1101-2021_01_06_425581 331 23 in in IN 10_1101-2021_01_06_425581 331 24 Xenopus Xenopus NNP 10_1101-2021_01_06_425581 331 25 laevis laevi NNS 10_1101-2021_01_06_425581 331 26 ​. ​. VBP 10_1101-2021_01_06_425581 332 1 ​Roux ​Roux NNP 10_1101-2021_01_06_425581 332 2 's 's POS 10_1101-2021_01_06_425581 332 3 Archives Archives NNP 10_1101-2021_01_06_425581 332 4 Developmental Developmental NNP 10_1101-2021_01_06_425581 332 5 Biology​ Biology​ NNP 10_1101-2021_01_06_425581 332 6 , , , 10_1101-2021_01_06_425581 332 7 192(5 192(5 CD 10_1101-2021_01_06_425581 332 8 ) ) -RRB- 10_1101-2021_01_06_425581 332 9 , , , 10_1101-2021_01_06_425581 332 10 216 216 CD 10_1101-2021_01_06_425581 332 11 - - SYM 10_1101-2021_01_06_425581 332 12 221 221 CD 10_1101-2021_01_06_425581 332 13 . . . 10_1101-2021_01_06_425581 333 1 [ [ -LRB- 10_1101-2021_01_06_425581 333 2 12 12 CD 10_1101-2021_01_06_425581 333 3 ] ] -RRB- 10_1101-2021_01_06_425581 333 4 Boterenbrood Boterenbrood NNP 10_1101-2021_01_06_425581 333 5 , , , 10_1101-2021_01_06_425581 333 6 E.C. E.C. NNP 10_1101-2021_01_06_425581 334 1 & & CC 10_1101-2021_01_06_425581 334 2 Narraway Narraway NNP 10_1101-2021_01_06_425581 334 3 , , , 10_1101-2021_01_06_425581 334 4 J.M. J.M. NNP 10_1101-2021_01_06_425581 335 1 ( ( -LRB- 10_1101-2021_01_06_425581 335 2 1986 1986 CD 10_1101-2021_01_06_425581 335 3 ) ) -RRB- 10_1101-2021_01_06_425581 335 4 . . . 10_1101-2021_01_06_425581 336 1 The the DT 10_1101-2021_01_06_425581 336 2 direction direction NN 10_1101-2021_01_06_425581 336 3 of of IN 10_1101-2021_01_06_425581 336 4 cleavage cleavage NN 10_1101-2021_01_06_425581 336 5 waves wave NNS 10_1101-2021_01_06_425581 336 6 and and CC 10_1101-2021_01_06_425581 336 7 the the DT 10_1101-2021_01_06_425581 336 8 regional regional JJ 10_1101-2021_01_06_425581 336 9 variation variation NN 10_1101-2021_01_06_425581 336 10 in in IN 10_1101-2021_01_06_425581 336 11 the the DT 10_1101-2021_01_06_425581 336 12 duration duration NN 10_1101-2021_01_06_425581 336 13 of of IN 10_1101-2021_01_06_425581 336 14 cleavage cleavage NN 10_1101-2021_01_06_425581 336 15 cycles cycle NNS 10_1101-2021_01_06_425581 336 16 on on IN 10_1101-2021_01_06_425581 336 17 the the DT 10_1101-2021_01_06_425581 336 18 dorsal dorsal NN 10_1101-2021_01_06_425581 336 19 side side NN 10_1101-2021_01_06_425581 336 20 of of IN 10_1101-2021_01_06_425581 336 21 the the DT 10_1101-2021_01_06_425581 336 22 Xenopus Xenopus NNP 10_1101-2021_01_06_425581 336 23 laevis laevis NN 10_1101-2021_01_06_425581 336 24 ​ ​ JJ 10_1101-2021_01_06_425581 336 25 blastula blastula NN 10_1101-2021_01_06_425581 336 26 . . . 10_1101-2021_01_06_425581 337 1 ​Roux ​Roux NNP 10_1101-2021_01_06_425581 337 2 's 's POS 10_1101-2021_01_06_425581 337 3 Archives archive NNS 10_1101-2021_01_06_425581 337 4 of of IN 10_1101-2021_01_06_425581 337 5 Developmental Developmental NNP 10_1101-2021_01_06_425581 337 6 Biology​ Biology​ NNP 10_1101-2021_01_06_425581 337 7 , , , 10_1101-2021_01_06_425581 337 8 195 195 CD 10_1101-2021_01_06_425581 337 9 , , , 10_1101-2021_01_06_425581 337 10 484 484 CD 10_1101-2021_01_06_425581 337 11 - - SYM 10_1101-2021_01_06_425581 337 12 488 488 CD 10_1101-2021_01_06_425581 337 13 . . . 10_1101-2021_01_06_425581 338 1 [ [ -LRB- 10_1101-2021_01_06_425581 338 2 13 13 CD 10_1101-2021_01_06_425581 338 3 ] ] -RRB- 10_1101-2021_01_06_425581 338 4 Gordon Gordon NNP 10_1101-2021_01_06_425581 338 5 , , , 10_1101-2021_01_06_425581 338 6 N.K. N.K. NNP 10_1101-2021_01_06_425581 339 1 & & CC 10_1101-2021_01_06_425581 339 2 Gordon Gordon NNP 10_1101-2021_01_06_425581 339 3 , , , 10_1101-2021_01_06_425581 339 4 R. R. NNP 10_1101-2021_01_06_425581 339 5 ( ( -LRB- 10_1101-2021_01_06_425581 339 6 2016 2016 CD 10_1101-2021_01_06_425581 339 7 ) ) -RRB- 10_1101-2021_01_06_425581 339 8 . . . 10_1101-2021_01_06_425581 340 1 Embryogenesis embryogenesis NN 10_1101-2021_01_06_425581 340 2 Explained explain VBD 10_1101-2021_01_06_425581 340 3 . . . 10_1101-2021_01_06_425581 341 1 World World NNP 10_1101-2021_01_06_425581 341 2 Scientific Scientific NNP 10_1101-2021_01_06_425581 341 3 Publishing Publishing NNP 10_1101-2021_01_06_425581 341 4 , , , 10_1101-2021_01_06_425581 341 5 Singapore Singapore NNP 10_1101-2021_01_06_425581 341 6 . . . 10_1101-2021_01_06_425581 342 1 16 16 CD 10_1101-2021_01_06_425581 342 2 .CC .CC : 10_1101-2021_01_06_425581 342 3 - - HYPH 10_1101-2021_01_06_425581 342 4 BY BY NNP 10_1101-2021_01_06_425581 342 5 - - HYPH 10_1101-2021_01_06_425581 342 6 NC NC NNP 10_1101-2021_01_06_425581 342 7 4.0 4.0 CD 10_1101-2021_01_06_425581 342 8 International international JJ 10_1101-2021_01_06_425581 342 9 licensemade licensemade NN 10_1101-2021_01_06_425581 342 10 available available JJ 10_1101-2021_01_06_425581 342 11 under under IN 10_1101-2021_01_06_425581 342 12 a a DT 10_1101-2021_01_06_425581 342 13 ( ( -LRB- 10_1101-2021_01_06_425581 342 14 which which WDT 10_1101-2021_01_06_425581 342 15 was be VBD 10_1101-2021_01_06_425581 342 16 not not RB 10_1101-2021_01_06_425581 342 17 certified certify VBN 10_1101-2021_01_06_425581 342 18 by by IN 10_1101-2021_01_06_425581 342 19 peer peer NN 10_1101-2021_01_06_425581 342 20 review review NN 10_1101-2021_01_06_425581 342 21 ) ) -RRB- 10_1101-2021_01_06_425581 342 22 is be VBZ 10_1101-2021_01_06_425581 342 23 the the DT 10_1101-2021_01_06_425581 342 24 author author NN 10_1101-2021_01_06_425581 342 25 / / SYM 10_1101-2021_01_06_425581 342 26 funder funder NN 10_1101-2021_01_06_425581 342 27 , , , 10_1101-2021_01_06_425581 342 28 who who WP 10_1101-2021_01_06_425581 342 29 has have VBZ 10_1101-2021_01_06_425581 342 30 granted grant VBN 10_1101-2021_01_06_425581 342 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 342 32 a a DT 10_1101-2021_01_06_425581 342 33 license license NN 10_1101-2021_01_06_425581 342 34 to to TO 10_1101-2021_01_06_425581 342 35 display display VB 10_1101-2021_01_06_425581 342 36 the the DT 10_1101-2021_01_06_425581 342 37 preprint preprint NN 10_1101-2021_01_06_425581 342 38 in in IN 10_1101-2021_01_06_425581 342 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 342 40 . . . 10_1101-2021_01_06_425581 343 1 It -PRON- PRP 10_1101-2021_01_06_425581 343 2 is be VBZ 10_1101-2021_01_06_425581 343 3 The the DT 10_1101-2021_01_06_425581 343 4 copyright copyright NN 10_1101-2021_01_06_425581 343 5 holder holder NN 10_1101-2021_01_06_425581 343 6 for for IN 10_1101-2021_01_06_425581 343 7 this this DT 10_1101-2021_01_06_425581 343 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 343 9 version version NN 10_1101-2021_01_06_425581 343 10 posted post VBD 10_1101-2021_01_06_425581 343 11 January January NNP 10_1101-2021_01_06_425581 343 12 8 8 CD 10_1101-2021_01_06_425581 343 13 , , , 10_1101-2021_01_06_425581 343 14 2021 2021 CD 10_1101-2021_01_06_425581 343 15 . . . 10_1101-2021_01_06_425581 343 16 ; ; : 10_1101-2021_01_06_425581 343 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 343 18 : : : 10_1101-2021_01_06_425581 343 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 343 20 preprint preprint NN 10_1101-2021_01_06_425581 343 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 343 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 343 23 [ [ -LRB- 10_1101-2021_01_06_425581 343 24 14 14 CD 10_1101-2021_01_06_425581 343 25 ] ] -RRB- 10_1101-2021_01_06_425581 343 26 Holtzer Holtzer NNP 10_1101-2021_01_06_425581 343 27 , , , 10_1101-2021_01_06_425581 343 28 H. H. NNP 10_1101-2021_01_06_425581 343 29 , , , 10_1101-2021_01_06_425581 343 30 Rubinstein Rubinstein NNP 10_1101-2021_01_06_425581 343 31 , , , 10_1101-2021_01_06_425581 343 32 N. N. NNP 10_1101-2021_01_06_425581 343 33 , , , 10_1101-2021_01_06_425581 343 34 Fellini Fellini NNP 10_1101-2021_01_06_425581 343 35 , , , 10_1101-2021_01_06_425581 343 36 S. S. NNP 10_1101-2021_01_06_425581 343 37 , , , 10_1101-2021_01_06_425581 343 38 Yeoh Yeoh NNP 10_1101-2021_01_06_425581 343 39 , , , 10_1101-2021_01_06_425581 343 40 G. G. NNP 10_1101-2021_01_06_425581 343 41 , , , 10_1101-2021_01_06_425581 343 42 Chi Chi NNP 10_1101-2021_01_06_425581 343 43 , , , 10_1101-2021_01_06_425581 343 44 J. J. NNP 10_1101-2021_01_06_425581 343 45 , , , 10_1101-2021_01_06_425581 343 46 Birnbaum Birnbaum NNP 10_1101-2021_01_06_425581 343 47 , , , 10_1101-2021_01_06_425581 343 48 J. J. NNP 10_1101-2021_01_06_425581 344 1 & & CC 10_1101-2021_01_06_425581 344 2 Okayama Okayama NNP 10_1101-2021_01_06_425581 344 3 , , , 10_1101-2021_01_06_425581 344 4 M. M. NNP 10_1101-2021_01_06_425581 344 5 ( ( -LRB- 10_1101-2021_01_06_425581 344 6 1975 1975 CD 10_1101-2021_01_06_425581 344 7 ) ) -RRB- 10_1101-2021_01_06_425581 344 8 . . . 10_1101-2021_01_06_425581 345 1 Lineages lineage NNS 10_1101-2021_01_06_425581 345 2 , , , 10_1101-2021_01_06_425581 345 3 quantal quantal JJ 10_1101-2021_01_06_425581 345 4 cell cell NN 10_1101-2021_01_06_425581 345 5 cycles cycle NNS 10_1101-2021_01_06_425581 345 6 , , , 10_1101-2021_01_06_425581 345 7 and and CC 10_1101-2021_01_06_425581 345 8 the the DT 10_1101-2021_01_06_425581 345 9 generation generation NN 10_1101-2021_01_06_425581 345 10 of of IN 10_1101-2021_01_06_425581 345 11 cell cell NN 10_1101-2021_01_06_425581 345 12 diversity diversity NN 10_1101-2021_01_06_425581 345 13 . . . 10_1101-2021_01_06_425581 346 1 ​Quarterly ​Quarterly NNP 10_1101-2021_01_06_425581 346 2 Reviews Reviews NNPS 10_1101-2021_01_06_425581 346 3 in in IN 10_1101-2021_01_06_425581 346 4 Biophysics Biophysics NNP 10_1101-2021_01_06_425581 346 5 ​ ​ NNP 10_1101-2021_01_06_425581 346 6 , , , 10_1101-2021_01_06_425581 346 7 8(4 8(4 NNP 10_1101-2021_01_06_425581 346 8 ) ) -RRB- 10_1101-2021_01_06_425581 346 9 , , , 10_1101-2021_01_06_425581 346 10 523 523 CD 10_1101-2021_01_06_425581 346 11 - - SYM 10_1101-2021_01_06_425581 346 12 557 557 CD 10_1101-2021_01_06_425581 346 13 . . . 10_1101-2021_01_06_425581 347 1 [ [ -LRB- 10_1101-2021_01_06_425581 347 2 15 15 CD 10_1101-2021_01_06_425581 347 3 ] ] -RRB- 10_1101-2021_01_06_425581 347 4 Holtzer Holtzer NNP 10_1101-2021_01_06_425581 347 5 , , , 10_1101-2021_01_06_425581 347 6 H. H. NNP 10_1101-2021_01_06_425581 347 7 , , , 10_1101-2021_01_06_425581 347 8 Biehl Biehl NNP 10_1101-2021_01_06_425581 347 9 , , , 10_1101-2021_01_06_425581 347 10 J. J. NNP 10_1101-2021_01_06_425581 347 11 , , , 10_1101-2021_01_06_425581 347 12 Antin Antin NNP 10_1101-2021_01_06_425581 347 13 , , , 10_1101-2021_01_06_425581 347 14 P. P. NNP 10_1101-2021_01_06_425581 347 15 , , , 10_1101-2021_01_06_425581 347 16 Tokunaka Tokunaka NNP 10_1101-2021_01_06_425581 347 17 , , , 10_1101-2021_01_06_425581 347 18 S. S. NNP 10_1101-2021_01_06_425581 347 19 , , , 10_1101-2021_01_06_425581 347 20 Sasse Sasse NNP 10_1101-2021_01_06_425581 347 21 , , , 10_1101-2021_01_06_425581 347 22 J. J. NNP 10_1101-2021_01_06_425581 347 23 , , , 10_1101-2021_01_06_425581 347 24 Pacifici Pacifici NNP 10_1101-2021_01_06_425581 347 25 , , , 10_1101-2021_01_06_425581 347 26 M. M. NNP 10_1101-2021_01_06_425581 347 27 & & CC 10_1101-2021_01_06_425581 347 28 Holtzer Holtzer NNP 10_1101-2021_01_06_425581 347 29 , , , 10_1101-2021_01_06_425581 347 30 S. S. NNP 10_1101-2021_01_06_425581 347 31 ( ( -LRB- 10_1101-2021_01_06_425581 347 32 1983 1983 CD 10_1101-2021_01_06_425581 347 33 ) ) -RRB- 10_1101-2021_01_06_425581 347 34 . . . 10_1101-2021_01_06_425581 348 1 Quantal quantal JJ 10_1101-2021_01_06_425581 348 2 and and CC 10_1101-2021_01_06_425581 348 3 proliferative proliferative JJ 10_1101-2021_01_06_425581 348 4 cell cell NN 10_1101-2021_01_06_425581 348 5 cycles cycle NNS 10_1101-2021_01_06_425581 348 6 : : : 10_1101-2021_01_06_425581 348 7 how how WRB 10_1101-2021_01_06_425581 348 8 lineages lineage NNS 10_1101-2021_01_06_425581 348 9 generate generate VBP 10_1101-2021_01_06_425581 348 10 cell cell NN 10_1101-2021_01_06_425581 348 11 diversity diversity NN 10_1101-2021_01_06_425581 348 12 and and CC 10_1101-2021_01_06_425581 348 13 maintain maintain VB 10_1101-2021_01_06_425581 348 14 fidelity fidelity NN 10_1101-2021_01_06_425581 348 15 . . . 10_1101-2021_01_06_425581 349 1 ​Progress ​progress NN 10_1101-2021_01_06_425581 349 2 in in IN 10_1101-2021_01_06_425581 349 3 Clinical Clinical NNP 10_1101-2021_01_06_425581 349 4 Biological Biological NNP 10_1101-2021_01_06_425581 349 5 Research​ Research​ NNP 10_1101-2021_01_06_425581 349 6 , , , 10_1101-2021_01_06_425581 349 7 134 134 CD 10_1101-2021_01_06_425581 349 8 , , , 10_1101-2021_01_06_425581 349 9 213 213 CD 10_1101-2021_01_06_425581 349 10 - - SYM 10_1101-2021_01_06_425581 349 11 227 227 CD 10_1101-2021_01_06_425581 349 12 . . . 10_1101-2021_01_06_425581 350 1 [ [ -LRB- 10_1101-2021_01_06_425581 350 2 16 16 CD 10_1101-2021_01_06_425581 350 3 ] ] -RRB- 10_1101-2021_01_06_425581 350 4 Bao Bao NNP 10_1101-2021_01_06_425581 350 5 , , , 10_1101-2021_01_06_425581 350 6 Z. Z. NNP 10_1101-2021_01_06_425581 350 7 , , , 10_1101-2021_01_06_425581 350 8 Murray Murray NNP 10_1101-2021_01_06_425581 350 9 , , , 10_1101-2021_01_06_425581 350 10 J.I. J.I. NNP 10_1101-2021_01_06_425581 350 11 , , , 10_1101-2021_01_06_425581 350 12 Boyle Boyle NNP 10_1101-2021_01_06_425581 350 13 , , , 10_1101-2021_01_06_425581 350 14 T. T. NNP 10_1101-2021_01_06_425581 350 15 , , , 10_1101-2021_01_06_425581 350 16 Ooi Ooi NNP 10_1101-2021_01_06_425581 350 17 , , , 10_1101-2021_01_06_425581 350 18 S.L. S.L. NNP 10_1101-2021_01_06_425581 350 19 , , , 10_1101-2021_01_06_425581 350 20 Sandel Sandel NNP 10_1101-2021_01_06_425581 350 21 , , , 10_1101-2021_01_06_425581 350 22 M.J. M.J. NNP 10_1101-2021_01_06_425581 350 23 , , , 10_1101-2021_01_06_425581 350 24 and and CC 10_1101-2021_01_06_425581 350 25 Waterston Waterston NNP 10_1101-2021_01_06_425581 350 26 , , , 10_1101-2021_01_06_425581 350 27 R.H. R.H. NNP 10_1101-2021_01_06_425581 350 28 ( ( -LRB- 10_1101-2021_01_06_425581 350 29 2006 2006 CD 10_1101-2021_01_06_425581 350 30 ) ) -RRB- 10_1101-2021_01_06_425581 350 31 . . . 10_1101-2021_01_06_425581 351 1 Automated automate VBN 10_1101-2021_01_06_425581 351 2 cell cell NN 10_1101-2021_01_06_425581 351 3 lineage lineage NN 10_1101-2021_01_06_425581 351 4 tracing trace VBG 10_1101-2021_01_06_425581 351 5 in in IN 10_1101-2021_01_06_425581 351 6 ​Caenorhabditis ​caenorhabditis JJ 10_1101-2021_01_06_425581 351 7 elegans elegan NNS 10_1101-2021_01_06_425581 351 8 ​. ​. VBP 10_1101-2021_01_06_425581 352 1 ​PNAS​ ​PNAS​ NNP 10_1101-2021_01_06_425581 352 2 , , , 10_1101-2021_01_06_425581 352 3 103(8 103(8 CD 10_1101-2021_01_06_425581 352 4 ) ) -RRB- 10_1101-2021_01_06_425581 352 5 , , , 10_1101-2021_01_06_425581 352 6 2707 2707 CD 10_1101-2021_01_06_425581 352 7 - - HYPH 10_1101-2021_01_06_425581 352 8 2712 2712 CD 10_1101-2021_01_06_425581 352 9 . . . 10_1101-2021_01_06_425581 353 1 [ [ -LRB- 10_1101-2021_01_06_425581 353 2 17 17 CD 10_1101-2021_01_06_425581 353 3 ] ] -RRB- 10_1101-2021_01_06_425581 353 4 Keller Keller NNP 10_1101-2021_01_06_425581 353 5 , , , 10_1101-2021_01_06_425581 353 6 P.J. P.J. NNP 10_1101-2021_01_06_425581 353 7 , , , 10_1101-2021_01_06_425581 353 8 Schmidt Schmidt NNP 10_1101-2021_01_06_425581 353 9 , , , 10_1101-2021_01_06_425581 353 10 A.D. A.D. NNP 10_1101-2021_01_06_425581 353 11 , , , 10_1101-2021_01_06_425581 353 12 Wittbrodt Wittbrodt NNP 10_1101-2021_01_06_425581 353 13 , , , 10_1101-2021_01_06_425581 353 14 J. J. NNP 10_1101-2021_01_06_425581 353 15 , , , 10_1101-2021_01_06_425581 353 16 and and CC 10_1101-2021_01_06_425581 353 17 Stelzer Stelzer NNP 10_1101-2021_01_06_425581 353 18 , , , 10_1101-2021_01_06_425581 353 19 E.H.K. E.H.K. NNP 10_1101-2021_01_06_425581 354 1 ( ( -LRB- 10_1101-2021_01_06_425581 354 2 2008 2008 CD 10_1101-2021_01_06_425581 354 3 ) ) -RRB- 10_1101-2021_01_06_425581 354 4 . . . 10_1101-2021_01_06_425581 355 1 Reconstruction reconstruction NN 10_1101-2021_01_06_425581 355 2 of of IN 10_1101-2021_01_06_425581 355 3 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 355 4 early early JJ 10_1101-2021_01_06_425581 355 5 embryonic embryonic JJ 10_1101-2021_01_06_425581 355 6 development development NN 10_1101-2021_01_06_425581 355 7 by by IN 10_1101-2021_01_06_425581 355 8 scanned scan VBN 10_1101-2021_01_06_425581 355 9 light light JJ 10_1101-2021_01_06_425581 355 10 sheet sheet NN 10_1101-2021_01_06_425581 355 11 microscopy microscopy JJ 10_1101-2021_01_06_425581 355 12 . . . 10_1101-2021_01_06_425581 356 1 ​Science ​Science NNP 10_1101-2021_01_06_425581 356 2 ​ ​ NNP 10_1101-2021_01_06_425581 356 3 , , , 10_1101-2021_01_06_425581 356 4 322(5904 322(5904 NNP 10_1101-2021_01_06_425581 356 5 ) ) -RRB- 10_1101-2021_01_06_425581 356 6 , , , 10_1101-2021_01_06_425581 356 7 1065 1065 CD 10_1101-2021_01_06_425581 356 8 - - SYM 10_1101-2021_01_06_425581 356 9 1069 1069 CD 10_1101-2021_01_06_425581 356 10 . . . 10_1101-2021_01_06_425581 357 1 [ [ -LRB- 10_1101-2021_01_06_425581 357 2 18 18 CD 10_1101-2021_01_06_425581 357 3 ] ] -RRB- 10_1101-2021_01_06_425581 357 4 Kimmel Kimmel NNP 10_1101-2021_01_06_425581 357 5 , , , 10_1101-2021_01_06_425581 357 6 C.B. C.B. NNP 10_1101-2021_01_06_425581 357 7 , , , 10_1101-2021_01_06_425581 357 8 Ballard Ballard NNP 10_1101-2021_01_06_425581 357 9 , , , 10_1101-2021_01_06_425581 357 10 W.W. W.W. NNP 10_1101-2021_01_06_425581 357 11 , , , 10_1101-2021_01_06_425581 357 12 Kimmel Kimmel NNP 10_1101-2021_01_06_425581 357 13 , , , 10_1101-2021_01_06_425581 357 14 S.R. S.R. NNP 10_1101-2021_01_06_425581 357 15 , , , 10_1101-2021_01_06_425581 357 16 Ullmann Ullmann NNP 10_1101-2021_01_06_425581 357 17 , , , 10_1101-2021_01_06_425581 357 18 B. B. NNP 10_1101-2021_01_06_425581 357 19 , , , 10_1101-2021_01_06_425581 357 20 and and CC 10_1101-2021_01_06_425581 357 21 Schilling Schilling NNP 10_1101-2021_01_06_425581 357 22 , , , 10_1101-2021_01_06_425581 357 23 T.F. T.F. NNP 10_1101-2021_01_06_425581 358 1 ( ( -LRB- 10_1101-2021_01_06_425581 358 2 1995 1995 CD 10_1101-2021_01_06_425581 358 3 ) ) -RRB- 10_1101-2021_01_06_425581 358 4 . . . 10_1101-2021_01_06_425581 359 1 Stages stage NNS 10_1101-2021_01_06_425581 359 2 of of IN 10_1101-2021_01_06_425581 359 3 Embryonic Embryonic NNP 10_1101-2021_01_06_425581 359 4 Development Development NNP 10_1101-2021_01_06_425581 359 5 of of IN 10_1101-2021_01_06_425581 359 6 the the DT 10_1101-2021_01_06_425581 359 7 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 359 8 . . . 10_1101-2021_01_06_425581 360 1 ​Developmental ​Developmental NNP 10_1101-2021_01_06_425581 360 2 Dynamics​ Dynamics​ NNP 10_1101-2021_01_06_425581 360 3 , , , 10_1101-2021_01_06_425581 360 4 203 203 CD 10_1101-2021_01_06_425581 360 5 , , , 10_1101-2021_01_06_425581 360 6 253 253 CD 10_1101-2021_01_06_425581 360 7 - - SYM 10_1101-2021_01_06_425581 360 8 310 310 CD 10_1101-2021_01_06_425581 360 9 . . . 10_1101-2021_01_06_425581 361 1 [ [ -LRB- 10_1101-2021_01_06_425581 361 2 19 19 CD 10_1101-2021_01_06_425581 361 3 ] ] -RRB- 10_1101-2021_01_06_425581 361 4 Raible raible JJ 10_1101-2021_01_06_425581 361 5 , , , 10_1101-2021_01_06_425581 361 6 D.W. D.W. NNP 10_1101-2021_01_06_425581 361 7 and and CC 10_1101-2021_01_06_425581 361 8 Eisen Eisen NNP 10_1101-2021_01_06_425581 361 9 , , , 10_1101-2021_01_06_425581 361 10 J.S. J.S. NNP 10_1101-2021_01_06_425581 362 1 ( ( -LRB- 10_1101-2021_01_06_425581 362 2 1996 1996 CD 10_1101-2021_01_06_425581 362 3 ) ) -RRB- 10_1101-2021_01_06_425581 362 4 . . . 10_1101-2021_01_06_425581 363 1 Regulative regulative JJ 10_1101-2021_01_06_425581 363 2 Interactions Interactions NNPS 10_1101-2021_01_06_425581 363 3 in in IN 10_1101-2021_01_06_425581 363 4 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 363 5 Neural Neural NNP 10_1101-2021_01_06_425581 363 6 Crest Crest NNP 10_1101-2021_01_06_425581 363 7 . . . 10_1101-2021_01_06_425581 364 1 ​Development ​development JJ 10_1101-2021_01_06_425581 364 2 ​ ​ NNP 10_1101-2021_01_06_425581 364 3 , , , 10_1101-2021_01_06_425581 364 4 122 122 CD 10_1101-2021_01_06_425581 364 5 , , , 10_1101-2021_01_06_425581 364 6 501 501 CD 10_1101-2021_01_06_425581 364 7 - - SYM 10_1101-2021_01_06_425581 364 8 507 507 CD 10_1101-2021_01_06_425581 364 9 . . . 10_1101-2021_01_06_425581 365 1 [ [ -LRB- 10_1101-2021_01_06_425581 365 2 20 20 CD 10_1101-2021_01_06_425581 365 3 ] ] -RRB- 10_1101-2021_01_06_425581 365 4 Menon Menon NNP 10_1101-2021_01_06_425581 365 5 , , , 10_1101-2021_01_06_425581 365 6 T. T. NNP 10_1101-2021_01_06_425581 365 7 , , , 10_1101-2021_01_06_425581 365 8 Borbora Borbora NNP 10_1101-2021_01_06_425581 365 9 , , , 10_1101-2021_01_06_425581 365 10 A.S. A.S. NNP 10_1101-2021_01_06_425581 365 11 , , , 10_1101-2021_01_06_425581 365 12 Kumar Kumar NNP 10_1101-2021_01_06_425581 365 13 , , , 10_1101-2021_01_06_425581 365 14 R. R. NNP 10_1101-2021_01_06_425581 365 15 , , , 10_1101-2021_01_06_425581 365 16 and and CC 10_1101-2021_01_06_425581 365 17 Nair Nair NNP 10_1101-2021_01_06_425581 365 18 , , , 10_1101-2021_01_06_425581 365 19 S. S. NNP 10_1101-2021_01_06_425581 365 20 ( ( -LRB- 10_1101-2021_01_06_425581 365 21 2020 2020 CD 10_1101-2021_01_06_425581 365 22 ) ) -RRB- 10_1101-2021_01_06_425581 365 23 . . . 10_1101-2021_01_06_425581 366 1 Dynamic dynamic JJ 10_1101-2021_01_06_425581 366 2 optima optimum NNS 10_1101-2021_01_06_425581 366 3 in in IN 10_1101-2021_01_06_425581 366 4 cell cell NN 10_1101-2021_01_06_425581 366 5 sizes size NNS 10_1101-2021_01_06_425581 366 6 during during IN 10_1101-2021_01_06_425581 366 7 early early JJ 10_1101-2021_01_06_425581 366 8 development development NN 10_1101-2021_01_06_425581 366 9 enable enable VBP 10_1101-2021_01_06_425581 366 10 normal normal JJ 10_1101-2021_01_06_425581 366 11 gastrulation gastrulation NN 10_1101-2021_01_06_425581 366 12 in in IN 10_1101-2021_01_06_425581 366 13 Zebrafish zebrafish JJ 10_1101-2021_01_06_425581 366 14 embryos embryo NNS 10_1101-2021_01_06_425581 366 15 . . . 10_1101-2021_01_06_425581 367 1 Developmental Developmental NNP 10_1101-2021_01_06_425581 367 2 Biology Biology NNP 10_1101-2021_01_06_425581 367 3 ​ ​ NNP 10_1101-2021_01_06_425581 367 4 , , , 10_1101-2021_01_06_425581 367 5 468(1 468(1 CD 10_1101-2021_01_06_425581 367 6 - - HYPH 10_1101-2021_01_06_425581 367 7 2 2 CD 10_1101-2021_01_06_425581 367 8 ) ) -RRB- 10_1101-2021_01_06_425581 367 9 , , , 10_1101-2021_01_06_425581 367 10 26 26 CD 10_1101-2021_01_06_425581 367 11 - - SYM 10_1101-2021_01_06_425581 367 12 40 40 CD 10_1101-2021_01_06_425581 367 13 . . . 10_1101-2021_01_06_425581 368 1 [ [ -LRB- 10_1101-2021_01_06_425581 368 2 21 21 CD 10_1101-2021_01_06_425581 368 3 ] ] -RRB- 10_1101-2021_01_06_425581 368 4 Shah Shah NNP 10_1101-2021_01_06_425581 368 5 , , , 10_1101-2021_01_06_425581 368 6 G. G. NNP 10_1101-2021_01_06_425581 368 7 , , , 10_1101-2021_01_06_425581 368 8 Thierbach Thierbach NNP 10_1101-2021_01_06_425581 368 9 , , , 10_1101-2021_01_06_425581 368 10 K. K. NNP 10_1101-2021_01_06_425581 368 11 , , , 10_1101-2021_01_06_425581 368 12 Schmid Schmid NNP 10_1101-2021_01_06_425581 368 13 , , , 10_1101-2021_01_06_425581 368 14 B. B. NNP 10_1101-2021_01_06_425581 368 15 , , , 10_1101-2021_01_06_425581 368 16 Waschke Waschke NNP 10_1101-2021_01_06_425581 368 17 , , , 10_1101-2021_01_06_425581 368 18 J. J. NNP 10_1101-2021_01_06_425581 368 19 , , , 10_1101-2021_01_06_425581 368 20 Reade Reade NNP 10_1101-2021_01_06_425581 368 21 , , , 10_1101-2021_01_06_425581 368 22 A. a. NN 10_1101-2021_01_06_425581 368 23 , , , 10_1101-2021_01_06_425581 368 24 Hlawitschka Hlawitschka NNP 10_1101-2021_01_06_425581 368 25 , , , 10_1101-2021_01_06_425581 368 26 M. M. NNP 10_1101-2021_01_06_425581 368 27 , , , 10_1101-2021_01_06_425581 368 28 Roeder Roeder NNP 10_1101-2021_01_06_425581 368 29 , , , 10_1101-2021_01_06_425581 368 30 I. i. NN 10_1101-2021_01_06_425581 368 31 , , , 10_1101-2021_01_06_425581 368 32 Scherf Scherf NNP 10_1101-2021_01_06_425581 368 33 , , , 10_1101-2021_01_06_425581 368 34 N. N. NNP 10_1101-2021_01_06_425581 368 35 , , , 10_1101-2021_01_06_425581 368 36 and and CC 10_1101-2021_01_06_425581 368 37 Huisken Huisken NNP 10_1101-2021_01_06_425581 368 38 , , , 10_1101-2021_01_06_425581 368 39 J. J. NNP 10_1101-2021_01_06_425581 369 1 ( ( -LRB- 10_1101-2021_01_06_425581 369 2 2019 2019 CD 10_1101-2021_01_06_425581 369 3 ) ) -RRB- 10_1101-2021_01_06_425581 369 4 . . . 10_1101-2021_01_06_425581 370 1 Multi multi JJ 10_1101-2021_01_06_425581 370 2 - - JJ 10_1101-2021_01_06_425581 370 3 scale scale JJ 10_1101-2021_01_06_425581 370 4 imaging imaging NN 10_1101-2021_01_06_425581 370 5 and and CC 10_1101-2021_01_06_425581 370 6 analysis analysis NN 10_1101-2021_01_06_425581 370 7 identify identify VBP 10_1101-2021_01_06_425581 370 8 pan pan NN 10_1101-2021_01_06_425581 370 9 - - HYPH 10_1101-2021_01_06_425581 370 10 embryo embryo JJ 10_1101-2021_01_06_425581 370 11 cell cell NN 10_1101-2021_01_06_425581 370 12 dynamics dynamic NNS 10_1101-2021_01_06_425581 370 13 of of IN 10_1101-2021_01_06_425581 370 14 germ germ NNP 10_1101-2021_01_06_425581 370 15 layer layer NN 10_1101-2021_01_06_425581 370 16 formation formation NN 10_1101-2021_01_06_425581 370 17 in in IN 10_1101-2021_01_06_425581 370 18 Zebrafish Zebrafish NNP 10_1101-2021_01_06_425581 370 19 . . . 10_1101-2021_01_06_425581 371 1 ​Nature ​nature JJ 10_1101-2021_01_06_425581 371 2 Communications communication NNS 10_1101-2021_01_06_425581 371 3 ​ ​ NNP 10_1101-2021_01_06_425581 371 4 , , , 10_1101-2021_01_06_425581 371 5 10 10 CD 10_1101-2021_01_06_425581 371 6 , , , 10_1101-2021_01_06_425581 371 7 5753 5753 CD 10_1101-2021_01_06_425581 371 8 . . . 10_1101-2021_01_06_425581 372 1 [ [ -LRB- 10_1101-2021_01_06_425581 372 2 22 22 CD 10_1101-2021_01_06_425581 372 3 ] ] -RRB- 10_1101-2021_01_06_425581 372 4 Desmaison Desmaison NNP 10_1101-2021_01_06_425581 372 5 , , , 10_1101-2021_01_06_425581 372 6 A. A. NNP 10_1101-2021_01_06_425581 372 7 , , , 10_1101-2021_01_06_425581 372 8 Guillaume Guillaume NNP 10_1101-2021_01_06_425581 372 9 , , , 10_1101-2021_01_06_425581 372 10 L. L. NNP 10_1101-2021_01_06_425581 372 11 , , , 10_1101-2021_01_06_425581 372 12 Triclin Triclin NNP 10_1101-2021_01_06_425581 372 13 , , , 10_1101-2021_01_06_425581 372 14 S. S. NNP 10_1101-2021_01_06_425581 372 15 , , , 10_1101-2021_01_06_425581 372 16 and and CC 10_1101-2021_01_06_425581 372 17 Weiss Weiss NNP 10_1101-2021_01_06_425581 372 18 , , , 10_1101-2021_01_06_425581 372 19 P. P. NNP 10_1101-2021_01_06_425581 372 20 , , , 10_1101-2021_01_06_425581 372 21 Ducommun Ducommun NNP 10_1101-2021_01_06_425581 372 22 , , , 10_1101-2021_01_06_425581 372 23 B. B. NNP 10_1101-2021_01_06_425581 372 24 , , , 10_1101-2021_01_06_425581 372 25 and and CC 10_1101-2021_01_06_425581 372 26 Lobjois Lobjois NNP 10_1101-2021_01_06_425581 372 27 , , , 10_1101-2021_01_06_425581 372 28 V. V. NNP 10_1101-2021_01_06_425581 372 29 ( ( -LRB- 10_1101-2021_01_06_425581 372 30 2018 2018 CD 10_1101-2021_01_06_425581 372 31 ) ) -RRB- 10_1101-2021_01_06_425581 372 32 . . . 10_1101-2021_01_06_425581 373 1 Impact impact NN 10_1101-2021_01_06_425581 373 2 of of IN 10_1101-2021_01_06_425581 373 3 physical physical JJ 10_1101-2021_01_06_425581 373 4 confinement confinement NN 10_1101-2021_01_06_425581 373 5 on on IN 10_1101-2021_01_06_425581 373 6 nuclei nuclei NN 10_1101-2021_01_06_425581 373 7 geometry geometry NN 10_1101-2021_01_06_425581 373 8 and and CC 10_1101-2021_01_06_425581 373 9 cell cell NN 10_1101-2021_01_06_425581 373 10 division division NN 10_1101-2021_01_06_425581 373 11 dynamics dynamic NNS 10_1101-2021_01_06_425581 373 12 in in IN 10_1101-2021_01_06_425581 373 13 3D 3D NNP 10_1101-2021_01_06_425581 373 14 spheroids spheroid NNS 10_1101-2021_01_06_425581 373 15 . . . 10_1101-2021_01_06_425581 374 1 ​Scientific ​scientific JJ 10_1101-2021_01_06_425581 374 2 Reports report NNS 10_1101-2021_01_06_425581 374 3 ​ ​ NNP 10_1101-2021_01_06_425581 374 4 , , , 10_1101-2021_01_06_425581 374 5 8 8 CD 10_1101-2021_01_06_425581 374 6 , , , 10_1101-2021_01_06_425581 374 7 8785 8785 CD 10_1101-2021_01_06_425581 374 8 . . . 10_1101-2021_01_06_425581 374 9 doi:10.1038 doi:10.1038 NNP 10_1101-2021_01_06_425581 374 10 / / SYM 10_1101-2021_01_06_425581 374 11 s41598 s41598 JJ 10_1101-2021_01_06_425581 374 12 - - HYPH 10_1101-2021_01_06_425581 374 13 018 018 CD 10_1101-2021_01_06_425581 374 14 - - HYPH 10_1101-2021_01_06_425581 374 15 27060 27060 CD 10_1101-2021_01_06_425581 374 16 - - SYM 10_1101-2021_01_06_425581 374 17 6 6 CD 10_1101-2021_01_06_425581 374 18 . . . 10_1101-2021_01_06_425581 375 1 [ [ -LRB- 10_1101-2021_01_06_425581 375 2 23 23 CD 10_1101-2021_01_06_425581 375 3 ] ] -RRB- 10_1101-2021_01_06_425581 375 4 Yoshizawa Yoshizawa NNP 10_1101-2021_01_06_425581 375 5 , , , 10_1101-2021_01_06_425581 375 6 M. M. NNP 10_1101-2021_01_06_425581 375 7 , , , 10_1101-2021_01_06_425581 375 8 Hixon Hixon NNP 10_1101-2021_01_06_425581 375 9 , , , 10_1101-2021_01_06_425581 375 10 E. E. NNP 10_1101-2021_01_06_425581 375 11 , , , 10_1101-2021_01_06_425581 375 12 and and CC 10_1101-2021_01_06_425581 375 13 Jeffery Jeffery NNP 10_1101-2021_01_06_425581 375 14 , , , 10_1101-2021_01_06_425581 375 15 W.R. W.R. NNP 10_1101-2021_01_06_425581 375 16 ( ( -LRB- 10_1101-2021_01_06_425581 375 17 2018 2018 CD 10_1101-2021_01_06_425581 375 18 ) ) -RRB- 10_1101-2021_01_06_425581 375 19 . . . 10_1101-2021_01_06_425581 376 1 Neural Neural NNP 10_1101-2021_01_06_425581 376 2 Crest Crest NNP 10_1101-2021_01_06_425581 376 3 Transplantation Transplantation NNP 10_1101-2021_01_06_425581 376 4 Reveals reveal VBZ 10_1101-2021_01_06_425581 376 5 Key Key NNP 10_1101-2021_01_06_425581 376 6 Roles Roles NNPS 10_1101-2021_01_06_425581 376 7 in in IN 10_1101-2021_01_06_425581 376 8 the the DT 10_1101-2021_01_06_425581 376 9 Evolution Evolution NNP 10_1101-2021_01_06_425581 376 10 of of IN 10_1101-2021_01_06_425581 376 11 Cavefish Cavefish NNP 10_1101-2021_01_06_425581 376 12 Development Development NNP 10_1101-2021_01_06_425581 376 13 . . . 10_1101-2021_01_06_425581 377 1 Integrative integrative JJ 10_1101-2021_01_06_425581 377 2 and and CC 10_1101-2021_01_06_425581 377 3 Comparative comparative JJ 10_1101-2021_01_06_425581 377 4 Biology Biology NNP 10_1101-2021_01_06_425581 377 5 ​ ​ NNP 10_1101-2021_01_06_425581 377 6 , , , 10_1101-2021_01_06_425581 377 7 58(3 58(3 JJ 10_1101-2021_01_06_425581 377 8 ) ) -RRB- 10_1101-2021_01_06_425581 377 9 , , , 10_1101-2021_01_06_425581 377 10 411 411 CD 10_1101-2021_01_06_425581 377 11 - - SYM 10_1101-2021_01_06_425581 377 12 420 420 CD 10_1101-2021_01_06_425581 377 13 . . . 10_1101-2021_01_06_425581 378 1 [ [ -LRB- 10_1101-2021_01_06_425581 378 2 24 24 CD 10_1101-2021_01_06_425581 378 3 ] ] -RRB- 10_1101-2021_01_06_425581 378 4 Fickentscher Fickentscher NNP 10_1101-2021_01_06_425581 378 5 . . . 10_1101-2021_01_06_425581 379 1 R. R. NNP 10_1101-2021_01_06_425581 379 2 and and CC 10_1101-2021_01_06_425581 379 3 Weiss Weiss NNP 10_1101-2021_01_06_425581 379 4 , , , 10_1101-2021_01_06_425581 379 5 M. M. NNP 10_1101-2021_01_06_425581 379 6 ( ( -LRB- 10_1101-2021_01_06_425581 379 7 2017 2017 CD 10_1101-2021_01_06_425581 379 8 ) ) -RRB- 10_1101-2021_01_06_425581 379 9 . . . 10_1101-2021_01_06_425581 380 1 Physical physical JJ 10_1101-2021_01_06_425581 380 2 determinants determinant NNS 10_1101-2021_01_06_425581 380 3 of of IN 10_1101-2021_01_06_425581 380 4 asymmetric asymmetric JJ 10_1101-2021_01_06_425581 380 5 cell cell NN 10_1101-2021_01_06_425581 380 6 divisions division NNS 10_1101-2021_01_06_425581 380 7 in in IN 10_1101-2021_01_06_425581 380 8 the the DT 10_1101-2021_01_06_425581 380 9 early early JJ 10_1101-2021_01_06_425581 380 10 development development NN 10_1101-2021_01_06_425581 380 11 of of IN 10_1101-2021_01_06_425581 380 12 ​Caenorhabditis ​caenorhabditis JJ 10_1101-2021_01_06_425581 380 13 elegans elegan NNS 10_1101-2021_01_06_425581 380 14 ​. ​. VBP 10_1101-2021_01_06_425581 381 1 ​Scientific ​scientific JJ 10_1101-2021_01_06_425581 381 2 Reports report NNS 10_1101-2021_01_06_425581 381 3 ​ ​ JJ 10_1101-2021_01_06_425581 381 4 , , , 10_1101-2021_01_06_425581 381 5 7 7 CD 10_1101-2021_01_06_425581 381 6 , , , 10_1101-2021_01_06_425581 381 7 9369 9369 CD 10_1101-2021_01_06_425581 381 8 . . . 10_1101-2021_01_06_425581 381 9 doi:10.1038 doi:10.1038 NNP 10_1101-2021_01_06_425581 381 10 / / SYM 10_1101-2021_01_06_425581 381 11 s41598 s41598 JJ 10_1101-2021_01_06_425581 381 12 - - HYPH 10_1101-2021_01_06_425581 381 13 017 017 CD 10_1101-2021_01_06_425581 381 14 - - HYPH 10_1101-2021_01_06_425581 381 15 09690 09690 CD 10_1101-2021_01_06_425581 381 16 - - HYPH 10_1101-2021_01_06_425581 381 17 4 4 CD 10_1101-2021_01_06_425581 381 18 . . . 10_1101-2021_01_06_425581 382 1 [ [ -LRB- 10_1101-2021_01_06_425581 382 2 25 25 CD 10_1101-2021_01_06_425581 382 3 ] ] -RRB- 10_1101-2021_01_06_425581 382 4 Alicea Alicea NNP 10_1101-2021_01_06_425581 382 5 , , , 10_1101-2021_01_06_425581 382 6 B. B. NNP 10_1101-2021_01_06_425581 382 7 and and CC 10_1101-2021_01_06_425581 382 8 Gordon Gordon NNP 10_1101-2021_01_06_425581 382 9 , , , 10_1101-2021_01_06_425581 382 10 R. R. NNP 10_1101-2021_01_06_425581 382 11 ( ( -LRB- 10_1101-2021_01_06_425581 382 12 2016 2016 CD 10_1101-2021_01_06_425581 382 13 ) ) -RRB- 10_1101-2021_01_06_425581 382 14 . . . 10_1101-2021_01_06_425581 383 1 Quantifying quantify VBG 10_1101-2021_01_06_425581 383 2 Mosaic Mosaic NNP 10_1101-2021_01_06_425581 383 3 Development Development NNP 10_1101-2021_01_06_425581 383 4 : : : 10_1101-2021_01_06_425581 383 5 Towards towards IN 10_1101-2021_01_06_425581 383 6 an an DT 10_1101-2021_01_06_425581 383 7 Evo Evo NNP 10_1101-2021_01_06_425581 383 8 - - HYPH 10_1101-2021_01_06_425581 383 9 Devo Devo NNP 10_1101-2021_01_06_425581 383 10 Postmodern Postmodern NNP 10_1101-2021_01_06_425581 383 11 Synthesis Synthesis NNP 10_1101-2021_01_06_425581 383 12 of of IN 10_1101-2021_01_06_425581 383 13 the the DT 10_1101-2021_01_06_425581 383 14 Evolution Evolution NNP 10_1101-2021_01_06_425581 383 15 of of IN 10_1101-2021_01_06_425581 383 16 Development Development NNP 10_1101-2021_01_06_425581 383 17 Via via IN 10_1101-2021_01_06_425581 383 18 Differentiation Differentiation NNP 10_1101-2021_01_06_425581 383 19 Trees Trees NNP 10_1101-2021_01_06_425581 383 20 of of IN 10_1101-2021_01_06_425581 383 21 Embryos Embryos NNP 10_1101-2021_01_06_425581 383 22 [ [ -LRB- 10_1101-2021_01_06_425581 383 23 invited invite VBN 10_1101-2021_01_06_425581 383 24 ] ] -RRB- 10_1101-2021_01_06_425581 383 25 . . . 10_1101-2021_01_06_425581 384 1 Biology biology NN 10_1101-2021_01_06_425581 384 2 , , , 10_1101-2021_01_06_425581 384 3 5(3 5(3 NNP 10_1101-2021_01_06_425581 384 4 ) ) -RRB- 10_1101-2021_01_06_425581 384 5 , , , 10_1101-2021_01_06_425581 384 6 33 33 CD 10_1101-2021_01_06_425581 384 7 . . . 10_1101-2021_01_06_425581 385 1 17 17 CD 10_1101-2021_01_06_425581 385 2 .CC .CC : 10_1101-2021_01_06_425581 385 3 - - HYPH 10_1101-2021_01_06_425581 385 4 BY BY NNP 10_1101-2021_01_06_425581 385 5 - - HYPH 10_1101-2021_01_06_425581 385 6 NC NC NNP 10_1101-2021_01_06_425581 385 7 4.0 4.0 CD 10_1101-2021_01_06_425581 385 8 International international JJ 10_1101-2021_01_06_425581 385 9 licensemade licensemade NN 10_1101-2021_01_06_425581 385 10 available available JJ 10_1101-2021_01_06_425581 385 11 under under IN 10_1101-2021_01_06_425581 385 12 a a DT 10_1101-2021_01_06_425581 385 13 ( ( -LRB- 10_1101-2021_01_06_425581 385 14 which which WDT 10_1101-2021_01_06_425581 385 15 was be VBD 10_1101-2021_01_06_425581 385 16 not not RB 10_1101-2021_01_06_425581 385 17 certified certify VBN 10_1101-2021_01_06_425581 385 18 by by IN 10_1101-2021_01_06_425581 385 19 peer peer NN 10_1101-2021_01_06_425581 385 20 review review NN 10_1101-2021_01_06_425581 385 21 ) ) -RRB- 10_1101-2021_01_06_425581 385 22 is be VBZ 10_1101-2021_01_06_425581 385 23 the the DT 10_1101-2021_01_06_425581 385 24 author author NN 10_1101-2021_01_06_425581 385 25 / / SYM 10_1101-2021_01_06_425581 385 26 funder funder NN 10_1101-2021_01_06_425581 385 27 , , , 10_1101-2021_01_06_425581 385 28 who who WP 10_1101-2021_01_06_425581 385 29 has have VBZ 10_1101-2021_01_06_425581 385 30 granted grant VBN 10_1101-2021_01_06_425581 385 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 385 32 a a DT 10_1101-2021_01_06_425581 385 33 license license NN 10_1101-2021_01_06_425581 385 34 to to TO 10_1101-2021_01_06_425581 385 35 display display VB 10_1101-2021_01_06_425581 385 36 the the DT 10_1101-2021_01_06_425581 385 37 preprint preprint NN 10_1101-2021_01_06_425581 385 38 in in IN 10_1101-2021_01_06_425581 385 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 385 40 . . . 10_1101-2021_01_06_425581 386 1 It -PRON- PRP 10_1101-2021_01_06_425581 386 2 is be VBZ 10_1101-2021_01_06_425581 386 3 The the DT 10_1101-2021_01_06_425581 386 4 copyright copyright NN 10_1101-2021_01_06_425581 386 5 holder holder NN 10_1101-2021_01_06_425581 386 6 for for IN 10_1101-2021_01_06_425581 386 7 this this DT 10_1101-2021_01_06_425581 386 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 386 9 version version NN 10_1101-2021_01_06_425581 386 10 posted post VBD 10_1101-2021_01_06_425581 386 11 January January NNP 10_1101-2021_01_06_425581 386 12 8 8 CD 10_1101-2021_01_06_425581 386 13 , , , 10_1101-2021_01_06_425581 386 14 2021 2021 CD 10_1101-2021_01_06_425581 386 15 . . . 10_1101-2021_01_06_425581 386 16 ; ; : 10_1101-2021_01_06_425581 386 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 386 18 : : : 10_1101-2021_01_06_425581 386 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 386 20 preprint preprint NN 10_1101-2021_01_06_425581 386 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 386 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 386 23 [ [ -LRB- 10_1101-2021_01_06_425581 386 24 26 26 CD 10_1101-2021_01_06_425581 386 25 ] ] -RRB- 10_1101-2021_01_06_425581 386 26 Leoni Leoni NNP 10_1101-2021_01_06_425581 386 27 , , , 10_1101-2021_01_06_425581 386 28 M. M. NNP 10_1101-2021_01_06_425581 386 29 , , , 10_1101-2021_01_06_425581 386 30 Manyuhina Manyuhina NNP 10_1101-2021_01_06_425581 386 31 , , , 10_1101-2021_01_06_425581 386 32 O.V. O.V. NNP 10_1101-2021_01_06_425581 386 33 , , , 10_1101-2021_01_06_425581 386 34 Bowick Bowick NNP 10_1101-2021_01_06_425581 386 35 , , , 10_1101-2021_01_06_425581 386 36 M.J. M.J. NNP 10_1101-2021_01_06_425581 386 37 , , , 10_1101-2021_01_06_425581 386 38 and and CC 10_1101-2021_01_06_425581 386 39 Marchetti Marchetti NNP 10_1101-2021_01_06_425581 386 40 , , , 10_1101-2021_01_06_425581 386 41 M.C. M.C. NNP 10_1101-2021_01_06_425581 387 1 ( ( -LRB- 10_1101-2021_01_06_425581 387 2 2017 2017 CD 10_1101-2021_01_06_425581 387 3 ) ) -RRB- 10_1101-2021_01_06_425581 387 4 . . . 10_1101-2021_01_06_425581 388 1 Defect defect JJ 10_1101-2021_01_06_425581 388 2 driven drive VBN 10_1101-2021_01_06_425581 388 3 shapes shape NNS 10_1101-2021_01_06_425581 388 4 in in IN 10_1101-2021_01_06_425581 388 5 nematic nematic JJ 10_1101-2021_01_06_425581 388 6 droplets droplet NNS 10_1101-2021_01_06_425581 388 7 : : : 10_1101-2021_01_06_425581 388 8 analogies analogy NNS 10_1101-2021_01_06_425581 388 9 with with IN 10_1101-2021_01_06_425581 388 10 cell cell NN 10_1101-2021_01_06_425581 388 11 division division NN 10_1101-2021_01_06_425581 388 12 . . . 10_1101-2021_01_06_425581 389 1 ​Soft ​Soft NNP 10_1101-2021_01_06_425581 389 2 Matter Matter NNP 10_1101-2021_01_06_425581 389 3 ​ ​ NNP 10_1101-2021_01_06_425581 389 4 , , , 10_1101-2021_01_06_425581 389 5 13 13 CD 10_1101-2021_01_06_425581 389 6 , , , 10_1101-2021_01_06_425581 389 7 1257 1257 CD 10_1101-2021_01_06_425581 389 8 - - SYM 10_1101-2021_01_06_425581 389 9 1266 1266 CD 10_1101-2021_01_06_425581 389 10 . . . 10_1101-2021_01_06_425581 389 11 doi:10.1039 doi:10.1039 NNP 10_1101-2021_01_06_425581 389 12 / / SYM 10_1101-2021_01_06_425581 389 13 C6SM02584F C6SM02584F NNP 10_1101-2021_01_06_425581 389 14 [ [ -LRB- 10_1101-2021_01_06_425581 389 15 27 27 CD 10_1101-2021_01_06_425581 389 16 ] ] -RRB- 10_1101-2021_01_06_425581 389 17 Bono Bono NNP 10_1101-2021_01_06_425581 389 18 , , , 10_1101-2021_01_06_425581 389 19 R. R. NNP 10_1101-2021_01_06_425581 389 20 , , , 10_1101-2021_01_06_425581 389 21 Blanca Blanca NNP 10_1101-2021_01_06_425581 389 22 , , , 10_1101-2021_01_06_425581 389 23 M.J. M.J. NNP 10_1101-2021_01_06_425581 389 24 , , , 10_1101-2021_01_06_425581 389 25 Arnau1 Arnau1 NNP 10_1101-2021_01_06_425581 389 26 , , , 10_1101-2021_01_06_425581 389 27 J. J. NNP 10_1101-2021_01_06_425581 389 28 , , , 10_1101-2021_01_06_425581 389 29 and and CC 10_1101-2021_01_06_425581 389 30 Gómez Gómez NNP 10_1101-2021_01_06_425581 389 31 - - HYPH 10_1101-2021_01_06_425581 389 32 Benito Benito NNP 10_1101-2021_01_06_425581 389 33 , , , 10_1101-2021_01_06_425581 389 34 J. J. NNP 10_1101-2021_01_06_425581 390 1 ( ( -LRB- 10_1101-2021_01_06_425581 390 2 2017 2017 CD 10_1101-2021_01_06_425581 390 3 ) ) -RRB- 10_1101-2021_01_06_425581 390 4 . . . 10_1101-2021_01_06_425581 391 1 Non non JJ 10_1101-2021_01_06_425581 391 2 - - JJ 10_1101-2021_01_06_425581 391 3 normal normal JJ 10_1101-2021_01_06_425581 391 4 Distributions distribution NNS 10_1101-2021_01_06_425581 391 5 Commonly commonly RB 10_1101-2021_01_06_425581 391 6 Used use VBN 10_1101-2021_01_06_425581 391 7 in in IN 10_1101-2021_01_06_425581 391 8 Health Health NNP 10_1101-2021_01_06_425581 391 9 , , , 10_1101-2021_01_06_425581 391 10 Education Education NNP 10_1101-2021_01_06_425581 391 11 , , , 10_1101-2021_01_06_425581 391 12 and and CC 10_1101-2021_01_06_425581 391 13 Social Social NNP 10_1101-2021_01_06_425581 391 14 Sciences Sciences NNPS 10_1101-2021_01_06_425581 391 15 : : : 10_1101-2021_01_06_425581 391 16 A a DT 10_1101-2021_01_06_425581 391 17 Systematic systematic JJ 10_1101-2021_01_06_425581 391 18 Review.​ review.​ NN 10_1101-2021_01_06_425581 391 19 Frontiers Frontiers NNPS 10_1101-2021_01_06_425581 391 20 in in IN 10_1101-2021_01_06_425581 391 21 Psychology Psychology NNP 10_1101-2021_01_06_425581 391 22 ​ ​ NNP 10_1101-2021_01_06_425581 391 23 , , , 10_1101-2021_01_06_425581 391 24 8 8 CD 10_1101-2021_01_06_425581 391 25 , , , 10_1101-2021_01_06_425581 391 26 1602 1602 CD 10_1101-2021_01_06_425581 391 27 . . . 10_1101-2021_01_06_425581 391 28 doi:10.3389 doi:10.3389 NNP 10_1101-2021_01_06_425581 391 29 / / SYM 10_1101-2021_01_06_425581 391 30 fpsyg.2017.01602 fpsyg.2017.01602 JJ 10_1101-2021_01_06_425581 391 31 [ [ -LRB- 10_1101-2021_01_06_425581 391 32 28 28 CD 10_1101-2021_01_06_425581 391 33 ] ] -RRB- 10_1101-2021_01_06_425581 391 34 Akbarpour Akbarpour NNP 10_1101-2021_01_06_425581 391 35 , , , 10_1101-2021_01_06_425581 391 36 M. M. NNP 10_1101-2021_01_06_425581 391 37 and and CC 10_1101-2021_01_06_425581 391 38 Jackson Jackson NNP 10_1101-2021_01_06_425581 391 39 , , , 10_1101-2021_01_06_425581 391 40 M. M. NNP 10_1101-2021_01_06_425581 391 41 ( ( -LRB- 10_1101-2021_01_06_425581 391 42 2018 2018 CD 10_1101-2021_01_06_425581 391 43 ) ) -RRB- 10_1101-2021_01_06_425581 391 44 . . . 10_1101-2021_01_06_425581 392 1 Diffusion diffusion NN 10_1101-2021_01_06_425581 392 2 in in IN 10_1101-2021_01_06_425581 392 3 networks network NNS 10_1101-2021_01_06_425581 392 4 and and CC 10_1101-2021_01_06_425581 392 5 the the DT 10_1101-2021_01_06_425581 392 6 virtue virtue NN 10_1101-2021_01_06_425581 392 7 of of IN 10_1101-2021_01_06_425581 392 8 burstiness burstiness NN 10_1101-2021_01_06_425581 392 9 . . . 10_1101-2021_01_06_425581 393 1 ​PNAS ​PNAS NNP 10_1101-2021_01_06_425581 393 2 ​ ​ NNP 10_1101-2021_01_06_425581 393 3 , , , 10_1101-2021_01_06_425581 393 4 115(30 115(30 CD 10_1101-2021_01_06_425581 393 5 ) ) -RRB- 10_1101-2021_01_06_425581 393 6 , , , 10_1101-2021_01_06_425581 393 7 E6996-E7004 e6996-e7004 UH 10_1101-2021_01_06_425581 393 8 . . . 10_1101-2021_01_06_425581 394 1 [ [ -LRB- 10_1101-2021_01_06_425581 394 2 29 29 CD 10_1101-2021_01_06_425581 394 3 ] ] -RRB- 10_1101-2021_01_06_425581 394 4 Ben Ben NNP 10_1101-2021_01_06_425581 394 5 - - HYPH 10_1101-2021_01_06_425581 394 6 Moshe Moshe NNP 10_1101-2021_01_06_425581 394 7 , , , 10_1101-2021_01_06_425581 394 8 S. S. NNP 10_1101-2021_01_06_425581 394 9 and and CC 10_1101-2021_01_06_425581 394 10 Itzkovitz Itzkovitz NNP 10_1101-2021_01_06_425581 394 11 , , , 10_1101-2021_01_06_425581 394 12 S. S. NNP 10_1101-2021_01_06_425581 394 13 ( ( -LRB- 10_1101-2021_01_06_425581 394 14 2016 2016 CD 10_1101-2021_01_06_425581 394 15 ) ) -RRB- 10_1101-2021_01_06_425581 394 16 . . . 10_1101-2021_01_06_425581 395 1 Bursting burst VBG 10_1101-2021_01_06_425581 395 2 through through IN 10_1101-2021_01_06_425581 395 3 the the DT 10_1101-2021_01_06_425581 395 4 cell cell NN 10_1101-2021_01_06_425581 395 5 cycle cycle NN 10_1101-2021_01_06_425581 395 6 . . . 10_1101-2021_01_06_425581 396 1 eLife​ eLife​ NNP 10_1101-2021_01_06_425581 396 2 , , , 10_1101-2021_01_06_425581 396 3 5 5 CD 10_1101-2021_01_06_425581 396 4 , , , 10_1101-2021_01_06_425581 396 5 e14953 e14953 NNS 10_1101-2021_01_06_425581 396 6 . . . 10_1101-2021_01_06_425581 397 1 [ [ -LRB- 10_1101-2021_01_06_425581 397 2 30 30 CD 10_1101-2021_01_06_425581 397 3 ] ] -RRB- 10_1101-2021_01_06_425581 397 4 Wang Wang NNP 10_1101-2021_01_06_425581 397 5 , , , 10_1101-2021_01_06_425581 397 6 H. H. NNP 10_1101-2021_01_06_425581 397 7 , , , 10_1101-2021_01_06_425581 397 8 Yuan Yuan NNP 10_1101-2021_01_06_425581 397 9 , , , 10_1101-2021_01_06_425581 397 10 Z. Z. NNP 10_1101-2021_01_06_425581 397 11 , , , 10_1101-2021_01_06_425581 397 12 Liu Liu NNP 10_1101-2021_01_06_425581 397 13 , , , 10_1101-2021_01_06_425581 397 14 P. P. NNP 10_1101-2021_01_06_425581 397 15 , , , 10_1101-2021_01_06_425581 397 16 and and CC 10_1101-2021_01_06_425581 397 17 Zhou Zhou NNP 10_1101-2021_01_06_425581 397 18 , , , 10_1101-2021_01_06_425581 397 19 T. t. NN 10_1101-2021_01_06_425581 397 20 ( ( -LRB- 10_1101-2021_01_06_425581 397 21 2015 2015 CD 10_1101-2021_01_06_425581 397 22 ) ) -RRB- 10_1101-2021_01_06_425581 397 23 . . . 10_1101-2021_01_06_425581 398 1 Division division NN 10_1101-2021_01_06_425581 398 2 time time NN 10_1101-2021_01_06_425581 398 3 - - HYPH 10_1101-2021_01_06_425581 398 4 based base VBN 10_1101-2021_01_06_425581 398 5 amplifiers amplifier NNS 10_1101-2021_01_06_425581 398 6 for for IN 10_1101-2021_01_06_425581 398 7 stochastic stochastic JJ 10_1101-2021_01_06_425581 398 8 gene gene NN 10_1101-2021_01_06_425581 398 9 expression expression NN 10_1101-2021_01_06_425581 398 10 . . . 10_1101-2021_01_06_425581 399 1 ​Molecular ​Molecular NNP 10_1101-2021_01_06_425581 399 2 Biosystems Biosystems NNPS 10_1101-2021_01_06_425581 399 3 ​ ​ NNP 10_1101-2021_01_06_425581 399 4 , , , 10_1101-2021_01_06_425581 399 5 11(9 11(9 CD 10_1101-2021_01_06_425581 399 6 ) ) -RRB- 10_1101-2021_01_06_425581 399 7 , , , 10_1101-2021_01_06_425581 399 8 2417 2417 CD 10_1101-2021_01_06_425581 399 9 - - SYM 10_1101-2021_01_06_425581 399 10 2428 2428 CD 10_1101-2021_01_06_425581 399 11 . . . 10_1101-2021_01_06_425581 399 12 doi doi XX 10_1101-2021_01_06_425581 399 13 : : : 10_1101-2021_01_06_425581 399 14 10.1039 10.1039 CD 10_1101-2021_01_06_425581 399 15 / / SYM 10_1101-2021_01_06_425581 399 16 c5mb00391a c5mb00391a NNP 10_1101-2021_01_06_425581 399 17 . . . 10_1101-2021_01_06_425581 400 1 [ [ -LRB- 10_1101-2021_01_06_425581 400 2 31 31 CD 10_1101-2021_01_06_425581 400 3 ] ] -RRB- 10_1101-2021_01_06_425581 400 4 Csikasz Csikasz NNP 10_1101-2021_01_06_425581 400 5 - - HYPH 10_1101-2021_01_06_425581 400 6 Nagy Nagy NNP 10_1101-2021_01_06_425581 400 7 , , , 10_1101-2021_01_06_425581 400 8 A. a. NN 10_1101-2021_01_06_425581 401 1 ( ( -LRB- 10_1101-2021_01_06_425581 401 2 2009 2009 CD 10_1101-2021_01_06_425581 401 3 ) ) -RRB- 10_1101-2021_01_06_425581 401 4 . . . 10_1101-2021_01_06_425581 402 1 Computational computational JJ 10_1101-2021_01_06_425581 402 2 systems system NNS 10_1101-2021_01_06_425581 402 3 biology biology NN 10_1101-2021_01_06_425581 402 4 of of IN 10_1101-2021_01_06_425581 402 5 the the DT 10_1101-2021_01_06_425581 402 6 cell cell NN 10_1101-2021_01_06_425581 402 7 cycle cycle NN 10_1101-2021_01_06_425581 402 8 . . . 10_1101-2021_01_06_425581 403 1 ​Briefs ​briefs XX 10_1101-2021_01_06_425581 403 2 in in IN 10_1101-2021_01_06_425581 403 3 Bioinformatics Bioinformatics NNP 10_1101-2021_01_06_425581 403 4 ​ ​ NNP 10_1101-2021_01_06_425581 403 5 , , , 10_1101-2021_01_06_425581 403 6 10(4 10(4 CD 10_1101-2021_01_06_425581 403 7 ) ) -RRB- 10_1101-2021_01_06_425581 403 8 , , , 10_1101-2021_01_06_425581 403 9 424 424 CD 10_1101-2021_01_06_425581 403 10 - - SYM 10_1101-2021_01_06_425581 403 11 434 434 CD 10_1101-2021_01_06_425581 403 12 . . . 10_1101-2021_01_06_425581 403 13 doi:10.1093 doi:10.1093 NNP 10_1101-2021_01_06_425581 403 14 / / SYM 10_1101-2021_01_06_425581 403 15 bib bib NNP 10_1101-2021_01_06_425581 403 16 / / SYM 10_1101-2021_01_06_425581 403 17 bbp005 bbp005 NNP 10_1101-2021_01_06_425581 403 18 . . . 10_1101-2021_01_06_425581 404 1 [ [ -LRB- 10_1101-2021_01_06_425581 404 2 32 32 CD 10_1101-2021_01_06_425581 404 3 ] ] -RRB- 10_1101-2021_01_06_425581 404 4 Dangarh Dangarh NNP 10_1101-2021_01_06_425581 404 5 , , , 10_1101-2021_01_06_425581 404 6 P. P. NNP 10_1101-2021_01_06_425581 404 7 , , , 10_1101-2021_01_06_425581 404 8 Pandey Pandey NNP 10_1101-2021_01_06_425581 404 9 , , , 10_1101-2021_01_06_425581 404 10 N. N. NNP 10_1101-2021_01_06_425581 404 11 , , , 10_1101-2021_01_06_425581 404 12 Vinod Vinod NNP 10_1101-2021_01_06_425581 404 13 , , , 10_1101-2021_01_06_425581 404 14 P.K. P.K. NNP 10_1101-2021_01_06_425581 405 1 ( ( -LRB- 10_1101-2021_01_06_425581 405 2 2020 2020 CD 10_1101-2021_01_06_425581 405 3 ) ) -RRB- 10_1101-2021_01_06_425581 405 4 . . . 10_1101-2021_01_06_425581 406 1 Modeling model VBG 10_1101-2021_01_06_425581 406 2 the the DT 10_1101-2021_01_06_425581 406 3 Control Control NNP 10_1101-2021_01_06_425581 406 4 of of IN 10_1101-2021_01_06_425581 406 5 Meiotic Meiotic NNP 10_1101-2021_01_06_425581 406 6 Cell Cell NNP 10_1101-2021_01_06_425581 406 7 Divisions Divisions NNPS 10_1101-2021_01_06_425581 406 8 : : : 10_1101-2021_01_06_425581 406 9 Entry Entry NNP 10_1101-2021_01_06_425581 406 10 , , , 10_1101-2021_01_06_425581 406 11 Progression Progression NNP 10_1101-2021_01_06_425581 406 12 , , , 10_1101-2021_01_06_425581 406 13 and and CC 10_1101-2021_01_06_425581 406 14 Exit exit NN 10_1101-2021_01_06_425581 406 15 . . . 10_1101-2021_01_06_425581 407 1 ​Biophysical ​biophysical JJ 10_1101-2021_01_06_425581 407 2 Journal Journal NNP 10_1101-2021_01_06_425581 407 3 ​ ​ NNP 10_1101-2021_01_06_425581 407 4 , , , 10_1101-2021_01_06_425581 407 5 119(5 119(5 CD 10_1101-2021_01_06_425581 407 6 ) ) -RRB- 10_1101-2021_01_06_425581 407 7 , , , 10_1101-2021_01_06_425581 407 8 1015 1015 CD 10_1101-2021_01_06_425581 407 9 - - SYM 10_1101-2021_01_06_425581 407 10 1024 1024 CD 10_1101-2021_01_06_425581 407 11 . . . 10_1101-2021_01_06_425581 407 12 doi:10.1016 doi:10.1016 JJ 10_1101-2021_01_06_425581 407 13 / / SYM 10_1101-2021_01_06_425581 407 14 j.bpj.2020.07.017 j.bpj.2020.07.017 NNS 10_1101-2021_01_06_425581 407 15 . . . 10_1101-2021_01_06_425581 408 1 [ [ -LRB- 10_1101-2021_01_06_425581 408 2 33 33 CD 10_1101-2021_01_06_425581 408 3 ] ] -RRB- 10_1101-2021_01_06_425581 408 4 Festuccia Festuccia NNP 10_1101-2021_01_06_425581 408 5 , , , 10_1101-2021_01_06_425581 408 6 N. N. NNP 10_1101-2021_01_06_425581 408 7 , , , 10_1101-2021_01_06_425581 408 8 Gonzalez Gonzalez NNP 10_1101-2021_01_06_425581 408 9 , , , 10_1101-2021_01_06_425581 408 10 I. I. NNP 10_1101-2021_01_06_425581 408 11 , , , 10_1101-2021_01_06_425581 408 12 Owens Owens NNP 10_1101-2021_01_06_425581 408 13 , , , 10_1101-2021_01_06_425581 408 14 N. N. NNP 10_1101-2021_01_06_425581 408 15 , , , 10_1101-2021_01_06_425581 408 16 and and CC 10_1101-2021_01_06_425581 408 17 Navarro Navarro NNP 10_1101-2021_01_06_425581 408 18 , , , 10_1101-2021_01_06_425581 408 19 P. P. NNP 10_1101-2021_01_06_425581 408 20 ( ( -LRB- 10_1101-2021_01_06_425581 408 21 2017 2017 CD 10_1101-2021_01_06_425581 408 22 ) ) -RRB- 10_1101-2021_01_06_425581 408 23 . . . 10_1101-2021_01_06_425581 409 1 Mitotic mitotic JJ 10_1101-2021_01_06_425581 409 2 bookmarking bookmarking NN 10_1101-2021_01_06_425581 409 3 in in IN 10_1101-2021_01_06_425581 409 4 development development NN 10_1101-2021_01_06_425581 409 5 and and CC 10_1101-2021_01_06_425581 409 6 stem stem NN 10_1101-2021_01_06_425581 409 7 cells cell NNS 10_1101-2021_01_06_425581 409 8 . . . 10_1101-2021_01_06_425581 410 1 ​Development​ ​development​ ADD 10_1101-2021_01_06_425581 410 2 , , , 10_1101-2021_01_06_425581 410 3 144 144 CD 10_1101-2021_01_06_425581 410 4 , , , 10_1101-2021_01_06_425581 410 5 3633 3633 CD 10_1101-2021_01_06_425581 410 6 - - SYM 10_1101-2021_01_06_425581 410 7 3645 3645 CD 10_1101-2021_01_06_425581 410 8 . . . 10_1101-2021_01_06_425581 411 1 [ [ -LRB- 10_1101-2021_01_06_425581 411 2 34 34 CD 10_1101-2021_01_06_425581 411 3 ] ] -RRB- 10_1101-2021_01_06_425581 411 4 Alfieri Alfieri NNP 10_1101-2021_01_06_425581 411 5 , , , 10_1101-2021_01_06_425581 411 6 R. R. NNP 10_1101-2021_01_06_425581 411 7 , , , 10_1101-2021_01_06_425581 411 8 Merelli Merelli NNP 10_1101-2021_01_06_425581 411 9 , , , 10_1101-2021_01_06_425581 411 10 I. I. NNP 10_1101-2021_01_06_425581 411 11 , , , 10_1101-2021_01_06_425581 411 12 Mosca Mosca NNP 10_1101-2021_01_06_425581 411 13 , , , 10_1101-2021_01_06_425581 411 14 E. E. NNP 10_1101-2021_01_06_425581 411 15 , , , 10_1101-2021_01_06_425581 411 16 and and CC 10_1101-2021_01_06_425581 411 17 Milanesi Milanesi NNP 10_1101-2021_01_06_425581 411 18 , , , 10_1101-2021_01_06_425581 411 19 L. L. NNP 10_1101-2021_01_06_425581 411 20 ( ( -LRB- 10_1101-2021_01_06_425581 411 21 2007 2007 CD 10_1101-2021_01_06_425581 411 22 ) ) -RRB- 10_1101-2021_01_06_425581 411 23 . . . 10_1101-2021_01_06_425581 412 1 A a DT 10_1101-2021_01_06_425581 412 2 data datum NNS 10_1101-2021_01_06_425581 412 3 integration integration NN 10_1101-2021_01_06_425581 412 4 approach approach NN 10_1101-2021_01_06_425581 412 5 for for IN 10_1101-2021_01_06_425581 412 6 cell cell NN 10_1101-2021_01_06_425581 412 7 cycle cycle NN 10_1101-2021_01_06_425581 412 8 analysis analysis NN 10_1101-2021_01_06_425581 412 9 oriented orient VBN 10_1101-2021_01_06_425581 412 10 to to IN 10_1101-2021_01_06_425581 412 11 model model NN 10_1101-2021_01_06_425581 412 12 simulation simulation NN 10_1101-2021_01_06_425581 412 13 in in IN 10_1101-2021_01_06_425581 412 14 systems system NNS 10_1101-2021_01_06_425581 412 15 biology biology NN 10_1101-2021_01_06_425581 412 16 . . . 10_1101-2021_01_06_425581 413 1 BMC BMC NNP 10_1101-2021_01_06_425581 413 2 Systems Systems NNPS 10_1101-2021_01_06_425581 413 3 Biology Biology NNP 10_1101-2021_01_06_425581 413 4 ​ ​ NNP 10_1101-2021_01_06_425581 413 5 , , , 10_1101-2021_01_06_425581 413 6 1 1 CD 10_1101-2021_01_06_425581 413 7 , , , 10_1101-2021_01_06_425581 413 8 35 35 CD 10_1101-2021_01_06_425581 413 9 . . . 10_1101-2021_01_06_425581 413 10 doi:10.1186/1752 doi:10.1186/1752 JJ 10_1101-2021_01_06_425581 413 11 - - HYPH 10_1101-2021_01_06_425581 413 12 0509 0509 CD 10_1101-2021_01_06_425581 413 13 - - HYPH 10_1101-2021_01_06_425581 413 14 1 1 CD 10_1101-2021_01_06_425581 413 15 - - HYPH 10_1101-2021_01_06_425581 413 16 35 35 CD 10_1101-2021_01_06_425581 413 17 . . . 10_1101-2021_01_06_425581 414 1 [ [ -LRB- 10_1101-2021_01_06_425581 414 2 35 35 CD 10_1101-2021_01_06_425581 414 3 ] ] -RRB- 10_1101-2021_01_06_425581 414 4 Halley Halley NNP 10_1101-2021_01_06_425581 414 5 - - HYPH 10_1101-2021_01_06_425581 414 6 Stott Stott NNP 10_1101-2021_01_06_425581 414 7 , , , 10_1101-2021_01_06_425581 414 8 R.P. R.P. NNP 10_1101-2021_01_06_425581 414 9 , , , 10_1101-2021_01_06_425581 414 10 Jullien Jullien NNP 10_1101-2021_01_06_425581 414 11 , , , 10_1101-2021_01_06_425581 414 12 J. J. NNP 10_1101-2021_01_06_425581 414 13 , , , 10_1101-2021_01_06_425581 414 14 Pasque Pasque NNP 10_1101-2021_01_06_425581 414 15 , , , 10_1101-2021_01_06_425581 414 16 V. V. NNP 10_1101-2021_01_06_425581 414 17 , , , 10_1101-2021_01_06_425581 414 18 and and CC 10_1101-2021_01_06_425581 414 19 Gurdon Gurdon NNP 10_1101-2021_01_06_425581 414 20 , , , 10_1101-2021_01_06_425581 414 21 J. J. NNP 10_1101-2021_01_06_425581 415 1 ( ( -LRB- 10_1101-2021_01_06_425581 415 2 2014 2014 CD 10_1101-2021_01_06_425581 415 3 ) ) -RRB- 10_1101-2021_01_06_425581 415 4 . . . 10_1101-2021_01_06_425581 416 1 Mitosis Mitosis NNP 10_1101-2021_01_06_425581 416 2 Gives give VBZ 10_1101-2021_01_06_425581 416 3 a a DT 10_1101-2021_01_06_425581 416 4 Brief Brief NNP 10_1101-2021_01_06_425581 416 5 Window Window NNP 10_1101-2021_01_06_425581 416 6 of of IN 10_1101-2021_01_06_425581 416 7 Opportunity Opportunity NNP 10_1101-2021_01_06_425581 416 8 for for IN 10_1101-2021_01_06_425581 416 9 a a DT 10_1101-2021_01_06_425581 416 10 Change change NN 10_1101-2021_01_06_425581 416 11 in in IN 10_1101-2021_01_06_425581 416 12 Gene Gene NNP 10_1101-2021_01_06_425581 416 13 Transcription Transcription NNP 10_1101-2021_01_06_425581 416 14 . . . 10_1101-2021_01_06_425581 417 1 ​PLoS ​PLoS : 10_1101-2021_01_06_425581 417 2 Biology​ Biology​ NNP 10_1101-2021_01_06_425581 417 3 , , , 10_1101-2021_01_06_425581 417 4 12(7 12(7 CD 10_1101-2021_01_06_425581 417 5 ) ) -RRB- 10_1101-2021_01_06_425581 417 6 , , , 10_1101-2021_01_06_425581 417 7 e1001914 e1001914 NNP 10_1101-2021_01_06_425581 417 8 . . . 10_1101-2021_01_06_425581 418 1 https://doi.org/10.1371/journal.pbio.1001914 https://doi.org/10.1371/journal.pbio.1001914 NNP 10_1101-2021_01_06_425581 418 2 [ [ -LRB- 10_1101-2021_01_06_425581 418 3 36 36 CD 10_1101-2021_01_06_425581 418 4 ] ] -RRB- 10_1101-2021_01_06_425581 418 5 Perez Perez NNP 10_1101-2021_01_06_425581 418 6 - - HYPH 10_1101-2021_01_06_425581 418 7 Carrasco Carrasco NNP 10_1101-2021_01_06_425581 418 8 , , , 10_1101-2021_01_06_425581 418 9 R. R. NNP 10_1101-2021_01_06_425581 418 10 , , , 10_1101-2021_01_06_425581 418 11 Beentjes Beentjes NNP 10_1101-2021_01_06_425581 418 12 , , , 10_1101-2021_01_06_425581 418 13 C. C. NNP 10_1101-2021_01_06_425581 418 14 and and CC 10_1101-2021_01_06_425581 418 15 Grima Grima NNP 10_1101-2021_01_06_425581 418 16 , , , 10_1101-2021_01_06_425581 418 17 R. R. NNP 10_1101-2021_01_06_425581 418 18 ( ( -LRB- 10_1101-2021_01_06_425581 418 19 2020 2020 CD 10_1101-2021_01_06_425581 418 20 ) ) -RRB- 10_1101-2021_01_06_425581 418 21 . . . 10_1101-2021_01_06_425581 419 1 Effects effect NNS 10_1101-2021_01_06_425581 419 2 of of IN 10_1101-2021_01_06_425581 419 3 cell cell NN 10_1101-2021_01_06_425581 419 4 cycle cycle NN 10_1101-2021_01_06_425581 419 5 variability variability NN 10_1101-2021_01_06_425581 419 6 on on IN 10_1101-2021_01_06_425581 419 7 lineage lineage NN 10_1101-2021_01_06_425581 419 8 and and CC 10_1101-2021_01_06_425581 419 9 population population NN 10_1101-2021_01_06_425581 419 10 measurements measurement NNS 10_1101-2021_01_06_425581 419 11 of of IN 10_1101-2021_01_06_425581 419 12 messenger messenger NN 10_1101-2021_01_06_425581 419 13 RNA RNA NNP 10_1101-2021_01_06_425581 419 14 abundance abundance NN 10_1101-2021_01_06_425581 419 15 . . . 10_1101-2021_01_06_425581 420 1 Journal Journal NNP 10_1101-2021_01_06_425581 420 2 of of IN 10_1101-2021_01_06_425581 420 3 the the DT 10_1101-2021_01_06_425581 420 4 Royal Royal NNP 10_1101-2021_01_06_425581 420 5 Society Society NNP 10_1101-2021_01_06_425581 420 6 Interface Interface NNP 10_1101-2021_01_06_425581 420 7 ​ ​ NNP 10_1101-2021_01_06_425581 420 8 , , , 10_1101-2021_01_06_425581 420 9 1720200360 1720200360 CD 10_1101-2021_01_06_425581 420 10 . . . 10_1101-2021_01_06_425581 421 1 [ [ -LRB- 10_1101-2021_01_06_425581 421 2 37 37 CD 10_1101-2021_01_06_425581 421 3 ] ] -RRB- 10_1101-2021_01_06_425581 421 4 Green Green NNP 10_1101-2021_01_06_425581 421 5 , , , 10_1101-2021_01_06_425581 421 6 J.B.A. J.B.A. NNP 10_1101-2021_01_06_425581 422 1 and and CC 10_1101-2021_01_06_425581 422 2 Sharpe Sharpe NNP 10_1101-2021_01_06_425581 422 3 , , , 10_1101-2021_01_06_425581 422 4 J. J. NNP 10_1101-2021_01_06_425581 423 1 ( ( -LRB- 10_1101-2021_01_06_425581 423 2 2015 2015 CD 10_1101-2021_01_06_425581 423 3 ) ) -RRB- 10_1101-2021_01_06_425581 423 4 . . . 10_1101-2021_01_06_425581 424 1 Positional positional JJ 10_1101-2021_01_06_425581 424 2 information information NN 10_1101-2021_01_06_425581 424 3 and and CC 10_1101-2021_01_06_425581 424 4 reaction reaction NN 10_1101-2021_01_06_425581 424 5 - - HYPH 10_1101-2021_01_06_425581 424 6 diffusion diffusion NN 10_1101-2021_01_06_425581 424 7 : : : 10_1101-2021_01_06_425581 424 8 two two CD 10_1101-2021_01_06_425581 424 9 big big JJ 10_1101-2021_01_06_425581 424 10 ideas idea NNS 10_1101-2021_01_06_425581 424 11 in in IN 10_1101-2021_01_06_425581 424 12 developmental developmental JJ 10_1101-2021_01_06_425581 424 13 biology biology NN 10_1101-2021_01_06_425581 424 14 combine combine NN 10_1101-2021_01_06_425581 424 15 . . . 10_1101-2021_01_06_425581 425 1 ​Development​ ​development​ ADD 10_1101-2021_01_06_425581 425 2 , , , 10_1101-2021_01_06_425581 425 3 142 142 CD 10_1101-2021_01_06_425581 425 4 , , , 10_1101-2021_01_06_425581 425 5 1203 1203 CD 10_1101-2021_01_06_425581 425 6 - - SYM 10_1101-2021_01_06_425581 425 7 1211 1211 CD 10_1101-2021_01_06_425581 425 8 ; ; : 10_1101-2021_01_06_425581 425 9 doi:10.1242 doi:10.1242 NNP 10_1101-2021_01_06_425581 425 10 / / SYM 10_1101-2021_01_06_425581 425 11 dev.114991 dev.114991 NNP 10_1101-2021_01_06_425581 425 12 . . . 10_1101-2021_01_06_425581 426 1 18 18 CD 10_1101-2021_01_06_425581 426 2 .CC .CC : 10_1101-2021_01_06_425581 426 3 - - HYPH 10_1101-2021_01_06_425581 426 4 BY BY NNP 10_1101-2021_01_06_425581 426 5 - - HYPH 10_1101-2021_01_06_425581 426 6 NC NC NNP 10_1101-2021_01_06_425581 426 7 4.0 4.0 CD 10_1101-2021_01_06_425581 426 8 International international JJ 10_1101-2021_01_06_425581 426 9 licensemade licensemade NN 10_1101-2021_01_06_425581 426 10 available available JJ 10_1101-2021_01_06_425581 426 11 under under IN 10_1101-2021_01_06_425581 426 12 a a DT 10_1101-2021_01_06_425581 426 13 ( ( -LRB- 10_1101-2021_01_06_425581 426 14 which which WDT 10_1101-2021_01_06_425581 426 15 was be VBD 10_1101-2021_01_06_425581 426 16 not not RB 10_1101-2021_01_06_425581 426 17 certified certify VBN 10_1101-2021_01_06_425581 426 18 by by IN 10_1101-2021_01_06_425581 426 19 peer peer NN 10_1101-2021_01_06_425581 426 20 review review NN 10_1101-2021_01_06_425581 426 21 ) ) -RRB- 10_1101-2021_01_06_425581 426 22 is be VBZ 10_1101-2021_01_06_425581 426 23 the the DT 10_1101-2021_01_06_425581 426 24 author author NN 10_1101-2021_01_06_425581 426 25 / / SYM 10_1101-2021_01_06_425581 426 26 funder funder NN 10_1101-2021_01_06_425581 426 27 , , , 10_1101-2021_01_06_425581 426 28 who who WP 10_1101-2021_01_06_425581 426 29 has have VBZ 10_1101-2021_01_06_425581 426 30 granted grant VBN 10_1101-2021_01_06_425581 426 31 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 426 32 a a DT 10_1101-2021_01_06_425581 426 33 license license NN 10_1101-2021_01_06_425581 426 34 to to TO 10_1101-2021_01_06_425581 426 35 display display VB 10_1101-2021_01_06_425581 426 36 the the DT 10_1101-2021_01_06_425581 426 37 preprint preprint NN 10_1101-2021_01_06_425581 426 38 in in IN 10_1101-2021_01_06_425581 426 39 perpetuity perpetuity NN 10_1101-2021_01_06_425581 426 40 . . . 10_1101-2021_01_06_425581 427 1 It -PRON- PRP 10_1101-2021_01_06_425581 427 2 is be VBZ 10_1101-2021_01_06_425581 427 3 The the DT 10_1101-2021_01_06_425581 427 4 copyright copyright NN 10_1101-2021_01_06_425581 427 5 holder holder NN 10_1101-2021_01_06_425581 427 6 for for IN 10_1101-2021_01_06_425581 427 7 this this DT 10_1101-2021_01_06_425581 427 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 427 9 version version NN 10_1101-2021_01_06_425581 427 10 posted post VBD 10_1101-2021_01_06_425581 427 11 January January NNP 10_1101-2021_01_06_425581 427 12 8 8 CD 10_1101-2021_01_06_425581 427 13 , , , 10_1101-2021_01_06_425581 427 14 2021 2021 CD 10_1101-2021_01_06_425581 427 15 . . . 10_1101-2021_01_06_425581 427 16 ; ; : 10_1101-2021_01_06_425581 427 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 427 18 : : : 10_1101-2021_01_06_425581 427 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 427 20 preprint preprint NN 10_1101-2021_01_06_425581 427 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 427 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 427 23 .CC .CC NFP 10_1101-2021_01_06_425581 427 24 - - : 10_1101-2021_01_06_425581 427 25 BY BY NNP 10_1101-2021_01_06_425581 427 26 - - HYPH 10_1101-2021_01_06_425581 427 27 NC NC NNP 10_1101-2021_01_06_425581 427 28 4.0 4.0 CD 10_1101-2021_01_06_425581 427 29 International international JJ 10_1101-2021_01_06_425581 427 30 licensemade licensemade NN 10_1101-2021_01_06_425581 427 31 available available JJ 10_1101-2021_01_06_425581 427 32 under under IN 10_1101-2021_01_06_425581 427 33 a a DT 10_1101-2021_01_06_425581 427 34 ( ( -LRB- 10_1101-2021_01_06_425581 427 35 which which WDT 10_1101-2021_01_06_425581 427 36 was be VBD 10_1101-2021_01_06_425581 427 37 not not RB 10_1101-2021_01_06_425581 427 38 certified certify VBN 10_1101-2021_01_06_425581 427 39 by by IN 10_1101-2021_01_06_425581 427 40 peer peer NN 10_1101-2021_01_06_425581 427 41 review review NN 10_1101-2021_01_06_425581 427 42 ) ) -RRB- 10_1101-2021_01_06_425581 427 43 is be VBZ 10_1101-2021_01_06_425581 427 44 the the DT 10_1101-2021_01_06_425581 427 45 author author NN 10_1101-2021_01_06_425581 427 46 / / SYM 10_1101-2021_01_06_425581 427 47 funder funder NN 10_1101-2021_01_06_425581 427 48 , , , 10_1101-2021_01_06_425581 427 49 who who WP 10_1101-2021_01_06_425581 427 50 has have VBZ 10_1101-2021_01_06_425581 427 51 granted grant VBN 10_1101-2021_01_06_425581 427 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 427 53 a a DT 10_1101-2021_01_06_425581 427 54 license license NN 10_1101-2021_01_06_425581 427 55 to to TO 10_1101-2021_01_06_425581 427 56 display display VB 10_1101-2021_01_06_425581 427 57 the the DT 10_1101-2021_01_06_425581 427 58 preprint preprint NN 10_1101-2021_01_06_425581 427 59 in in IN 10_1101-2021_01_06_425581 427 60 perpetuity perpetuity NN 10_1101-2021_01_06_425581 427 61 . . . 10_1101-2021_01_06_425581 428 1 It -PRON- PRP 10_1101-2021_01_06_425581 428 2 is be VBZ 10_1101-2021_01_06_425581 428 3 The the DT 10_1101-2021_01_06_425581 428 4 copyright copyright NN 10_1101-2021_01_06_425581 428 5 holder holder NN 10_1101-2021_01_06_425581 428 6 for for IN 10_1101-2021_01_06_425581 428 7 this this DT 10_1101-2021_01_06_425581 428 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 428 9 version version NN 10_1101-2021_01_06_425581 428 10 posted post VBD 10_1101-2021_01_06_425581 428 11 January January NNP 10_1101-2021_01_06_425581 428 12 8 8 CD 10_1101-2021_01_06_425581 428 13 , , , 10_1101-2021_01_06_425581 428 14 2021 2021 CD 10_1101-2021_01_06_425581 428 15 . . . 10_1101-2021_01_06_425581 428 16 ; ; : 10_1101-2021_01_06_425581 428 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 428 18 : : : 10_1101-2021_01_06_425581 428 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 428 20 preprint preprint NN 10_1101-2021_01_06_425581 428 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 428 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 428 23 .CC .CC NFP 10_1101-2021_01_06_425581 428 24 - - : 10_1101-2021_01_06_425581 428 25 BY BY NNP 10_1101-2021_01_06_425581 428 26 - - HYPH 10_1101-2021_01_06_425581 428 27 NC NC NNP 10_1101-2021_01_06_425581 428 28 4.0 4.0 CD 10_1101-2021_01_06_425581 428 29 International international JJ 10_1101-2021_01_06_425581 428 30 licensemade licensemade NN 10_1101-2021_01_06_425581 428 31 available available JJ 10_1101-2021_01_06_425581 428 32 under under IN 10_1101-2021_01_06_425581 428 33 a a DT 10_1101-2021_01_06_425581 428 34 ( ( -LRB- 10_1101-2021_01_06_425581 428 35 which which WDT 10_1101-2021_01_06_425581 428 36 was be VBD 10_1101-2021_01_06_425581 428 37 not not RB 10_1101-2021_01_06_425581 428 38 certified certify VBN 10_1101-2021_01_06_425581 428 39 by by IN 10_1101-2021_01_06_425581 428 40 peer peer NN 10_1101-2021_01_06_425581 428 41 review review NN 10_1101-2021_01_06_425581 428 42 ) ) -RRB- 10_1101-2021_01_06_425581 428 43 is be VBZ 10_1101-2021_01_06_425581 428 44 the the DT 10_1101-2021_01_06_425581 428 45 author author NN 10_1101-2021_01_06_425581 428 46 / / SYM 10_1101-2021_01_06_425581 428 47 funder funder NN 10_1101-2021_01_06_425581 428 48 , , , 10_1101-2021_01_06_425581 428 49 who who WP 10_1101-2021_01_06_425581 428 50 has have VBZ 10_1101-2021_01_06_425581 428 51 granted grant VBN 10_1101-2021_01_06_425581 428 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 428 53 a a DT 10_1101-2021_01_06_425581 428 54 license license NN 10_1101-2021_01_06_425581 428 55 to to TO 10_1101-2021_01_06_425581 428 56 display display VB 10_1101-2021_01_06_425581 428 57 the the DT 10_1101-2021_01_06_425581 428 58 preprint preprint NN 10_1101-2021_01_06_425581 428 59 in in IN 10_1101-2021_01_06_425581 428 60 perpetuity perpetuity NN 10_1101-2021_01_06_425581 428 61 . . . 10_1101-2021_01_06_425581 429 1 It -PRON- PRP 10_1101-2021_01_06_425581 429 2 is be VBZ 10_1101-2021_01_06_425581 429 3 The the DT 10_1101-2021_01_06_425581 429 4 copyright copyright NN 10_1101-2021_01_06_425581 429 5 holder holder NN 10_1101-2021_01_06_425581 429 6 for for IN 10_1101-2021_01_06_425581 429 7 this this DT 10_1101-2021_01_06_425581 429 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 429 9 version version NN 10_1101-2021_01_06_425581 429 10 posted post VBD 10_1101-2021_01_06_425581 429 11 January January NNP 10_1101-2021_01_06_425581 429 12 8 8 CD 10_1101-2021_01_06_425581 429 13 , , , 10_1101-2021_01_06_425581 429 14 2021 2021 CD 10_1101-2021_01_06_425581 429 15 . . . 10_1101-2021_01_06_425581 429 16 ; ; : 10_1101-2021_01_06_425581 429 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 429 18 : : : 10_1101-2021_01_06_425581 429 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 429 20 preprint preprint NN 10_1101-2021_01_06_425581 429 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 429 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 429 23 .CC .CC NFP 10_1101-2021_01_06_425581 429 24 - - : 10_1101-2021_01_06_425581 429 25 BY BY NNP 10_1101-2021_01_06_425581 429 26 - - HYPH 10_1101-2021_01_06_425581 429 27 NC NC NNP 10_1101-2021_01_06_425581 429 28 4.0 4.0 CD 10_1101-2021_01_06_425581 429 29 International international JJ 10_1101-2021_01_06_425581 429 30 licensemade licensemade NN 10_1101-2021_01_06_425581 429 31 available available JJ 10_1101-2021_01_06_425581 429 32 under under IN 10_1101-2021_01_06_425581 429 33 a a DT 10_1101-2021_01_06_425581 429 34 ( ( -LRB- 10_1101-2021_01_06_425581 429 35 which which WDT 10_1101-2021_01_06_425581 429 36 was be VBD 10_1101-2021_01_06_425581 429 37 not not RB 10_1101-2021_01_06_425581 429 38 certified certify VBN 10_1101-2021_01_06_425581 429 39 by by IN 10_1101-2021_01_06_425581 429 40 peer peer NN 10_1101-2021_01_06_425581 429 41 review review NN 10_1101-2021_01_06_425581 429 42 ) ) -RRB- 10_1101-2021_01_06_425581 429 43 is be VBZ 10_1101-2021_01_06_425581 429 44 the the DT 10_1101-2021_01_06_425581 429 45 author author NN 10_1101-2021_01_06_425581 429 46 / / SYM 10_1101-2021_01_06_425581 429 47 funder funder NN 10_1101-2021_01_06_425581 429 48 , , , 10_1101-2021_01_06_425581 429 49 who who WP 10_1101-2021_01_06_425581 429 50 has have VBZ 10_1101-2021_01_06_425581 429 51 granted grant VBN 10_1101-2021_01_06_425581 429 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 429 53 a a DT 10_1101-2021_01_06_425581 429 54 license license NN 10_1101-2021_01_06_425581 429 55 to to TO 10_1101-2021_01_06_425581 429 56 display display VB 10_1101-2021_01_06_425581 429 57 the the DT 10_1101-2021_01_06_425581 429 58 preprint preprint NN 10_1101-2021_01_06_425581 429 59 in in IN 10_1101-2021_01_06_425581 429 60 perpetuity perpetuity NN 10_1101-2021_01_06_425581 429 61 . . . 10_1101-2021_01_06_425581 430 1 It -PRON- PRP 10_1101-2021_01_06_425581 430 2 is be VBZ 10_1101-2021_01_06_425581 430 3 The the DT 10_1101-2021_01_06_425581 430 4 copyright copyright NN 10_1101-2021_01_06_425581 430 5 holder holder NN 10_1101-2021_01_06_425581 430 6 for for IN 10_1101-2021_01_06_425581 430 7 this this DT 10_1101-2021_01_06_425581 430 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 430 9 version version NN 10_1101-2021_01_06_425581 430 10 posted post VBD 10_1101-2021_01_06_425581 430 11 January January NNP 10_1101-2021_01_06_425581 430 12 8 8 CD 10_1101-2021_01_06_425581 430 13 , , , 10_1101-2021_01_06_425581 430 14 2021 2021 CD 10_1101-2021_01_06_425581 430 15 . . . 10_1101-2021_01_06_425581 430 16 ; ; : 10_1101-2021_01_06_425581 430 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 430 18 : : : 10_1101-2021_01_06_425581 430 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 430 20 preprint preprint NN 10_1101-2021_01_06_425581 430 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 430 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 430 23 .CC .CC NFP 10_1101-2021_01_06_425581 430 24 - - : 10_1101-2021_01_06_425581 430 25 BY BY NNP 10_1101-2021_01_06_425581 430 26 - - HYPH 10_1101-2021_01_06_425581 430 27 NC NC NNP 10_1101-2021_01_06_425581 430 28 4.0 4.0 CD 10_1101-2021_01_06_425581 430 29 International international JJ 10_1101-2021_01_06_425581 430 30 licensemade licensemade NN 10_1101-2021_01_06_425581 430 31 available available JJ 10_1101-2021_01_06_425581 430 32 under under IN 10_1101-2021_01_06_425581 430 33 a a DT 10_1101-2021_01_06_425581 430 34 ( ( -LRB- 10_1101-2021_01_06_425581 430 35 which which WDT 10_1101-2021_01_06_425581 430 36 was be VBD 10_1101-2021_01_06_425581 430 37 not not RB 10_1101-2021_01_06_425581 430 38 certified certify VBN 10_1101-2021_01_06_425581 430 39 by by IN 10_1101-2021_01_06_425581 430 40 peer peer NN 10_1101-2021_01_06_425581 430 41 review review NN 10_1101-2021_01_06_425581 430 42 ) ) -RRB- 10_1101-2021_01_06_425581 430 43 is be VBZ 10_1101-2021_01_06_425581 430 44 the the DT 10_1101-2021_01_06_425581 430 45 author author NN 10_1101-2021_01_06_425581 430 46 / / SYM 10_1101-2021_01_06_425581 430 47 funder funder NN 10_1101-2021_01_06_425581 430 48 , , , 10_1101-2021_01_06_425581 430 49 who who WP 10_1101-2021_01_06_425581 430 50 has have VBZ 10_1101-2021_01_06_425581 430 51 granted grant VBN 10_1101-2021_01_06_425581 430 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 430 53 a a DT 10_1101-2021_01_06_425581 430 54 license license NN 10_1101-2021_01_06_425581 430 55 to to TO 10_1101-2021_01_06_425581 430 56 display display VB 10_1101-2021_01_06_425581 430 57 the the DT 10_1101-2021_01_06_425581 430 58 preprint preprint NN 10_1101-2021_01_06_425581 430 59 in in IN 10_1101-2021_01_06_425581 430 60 perpetuity perpetuity NN 10_1101-2021_01_06_425581 430 61 . . . 10_1101-2021_01_06_425581 431 1 It -PRON- PRP 10_1101-2021_01_06_425581 431 2 is be VBZ 10_1101-2021_01_06_425581 431 3 The the DT 10_1101-2021_01_06_425581 431 4 copyright copyright NN 10_1101-2021_01_06_425581 431 5 holder holder NN 10_1101-2021_01_06_425581 431 6 for for IN 10_1101-2021_01_06_425581 431 7 this this DT 10_1101-2021_01_06_425581 431 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 431 9 version version NN 10_1101-2021_01_06_425581 431 10 posted post VBD 10_1101-2021_01_06_425581 431 11 January January NNP 10_1101-2021_01_06_425581 431 12 8 8 CD 10_1101-2021_01_06_425581 431 13 , , , 10_1101-2021_01_06_425581 431 14 2021 2021 CD 10_1101-2021_01_06_425581 431 15 . . . 10_1101-2021_01_06_425581 431 16 ; ; : 10_1101-2021_01_06_425581 431 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 431 18 : : : 10_1101-2021_01_06_425581 431 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 431 20 preprint preprint NN 10_1101-2021_01_06_425581 431 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 431 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 431 23 .CC .CC NFP 10_1101-2021_01_06_425581 431 24 - - : 10_1101-2021_01_06_425581 431 25 BY BY NNP 10_1101-2021_01_06_425581 431 26 - - HYPH 10_1101-2021_01_06_425581 431 27 NC NC NNP 10_1101-2021_01_06_425581 431 28 4.0 4.0 CD 10_1101-2021_01_06_425581 431 29 International international JJ 10_1101-2021_01_06_425581 431 30 licensemade licensemade NN 10_1101-2021_01_06_425581 431 31 available available JJ 10_1101-2021_01_06_425581 431 32 under under IN 10_1101-2021_01_06_425581 431 33 a a DT 10_1101-2021_01_06_425581 431 34 ( ( -LRB- 10_1101-2021_01_06_425581 431 35 which which WDT 10_1101-2021_01_06_425581 431 36 was be VBD 10_1101-2021_01_06_425581 431 37 not not RB 10_1101-2021_01_06_425581 431 38 certified certify VBN 10_1101-2021_01_06_425581 431 39 by by IN 10_1101-2021_01_06_425581 431 40 peer peer NN 10_1101-2021_01_06_425581 431 41 review review NN 10_1101-2021_01_06_425581 431 42 ) ) -RRB- 10_1101-2021_01_06_425581 431 43 is be VBZ 10_1101-2021_01_06_425581 431 44 the the DT 10_1101-2021_01_06_425581 431 45 author author NN 10_1101-2021_01_06_425581 431 46 / / SYM 10_1101-2021_01_06_425581 431 47 funder funder NN 10_1101-2021_01_06_425581 431 48 , , , 10_1101-2021_01_06_425581 431 49 who who WP 10_1101-2021_01_06_425581 431 50 has have VBZ 10_1101-2021_01_06_425581 431 51 granted grant VBN 10_1101-2021_01_06_425581 431 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 431 53 a a DT 10_1101-2021_01_06_425581 431 54 license license NN 10_1101-2021_01_06_425581 431 55 to to TO 10_1101-2021_01_06_425581 431 56 display display VB 10_1101-2021_01_06_425581 431 57 the the DT 10_1101-2021_01_06_425581 431 58 preprint preprint NN 10_1101-2021_01_06_425581 431 59 in in IN 10_1101-2021_01_06_425581 431 60 perpetuity perpetuity NN 10_1101-2021_01_06_425581 431 61 . . . 10_1101-2021_01_06_425581 432 1 It -PRON- PRP 10_1101-2021_01_06_425581 432 2 is be VBZ 10_1101-2021_01_06_425581 432 3 The the DT 10_1101-2021_01_06_425581 432 4 copyright copyright NN 10_1101-2021_01_06_425581 432 5 holder holder NN 10_1101-2021_01_06_425581 432 6 for for IN 10_1101-2021_01_06_425581 432 7 this this DT 10_1101-2021_01_06_425581 432 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 432 9 version version NN 10_1101-2021_01_06_425581 432 10 posted post VBD 10_1101-2021_01_06_425581 432 11 January January NNP 10_1101-2021_01_06_425581 432 12 8 8 CD 10_1101-2021_01_06_425581 432 13 , , , 10_1101-2021_01_06_425581 432 14 2021 2021 CD 10_1101-2021_01_06_425581 432 15 . . . 10_1101-2021_01_06_425581 432 16 ; ; : 10_1101-2021_01_06_425581 432 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 432 18 : : : 10_1101-2021_01_06_425581 432 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 432 20 preprint preprint NN 10_1101-2021_01_06_425581 432 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 432 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 432 23 .CC .CC NFP 10_1101-2021_01_06_425581 432 24 - - : 10_1101-2021_01_06_425581 432 25 BY BY NNP 10_1101-2021_01_06_425581 432 26 - - HYPH 10_1101-2021_01_06_425581 432 27 NC NC NNP 10_1101-2021_01_06_425581 432 28 4.0 4.0 CD 10_1101-2021_01_06_425581 432 29 International international JJ 10_1101-2021_01_06_425581 432 30 licensemade licensemade NN 10_1101-2021_01_06_425581 432 31 available available JJ 10_1101-2021_01_06_425581 432 32 under under IN 10_1101-2021_01_06_425581 432 33 a a DT 10_1101-2021_01_06_425581 432 34 ( ( -LRB- 10_1101-2021_01_06_425581 432 35 which which WDT 10_1101-2021_01_06_425581 432 36 was be VBD 10_1101-2021_01_06_425581 432 37 not not RB 10_1101-2021_01_06_425581 432 38 certified certify VBN 10_1101-2021_01_06_425581 432 39 by by IN 10_1101-2021_01_06_425581 432 40 peer peer NN 10_1101-2021_01_06_425581 432 41 review review NN 10_1101-2021_01_06_425581 432 42 ) ) -RRB- 10_1101-2021_01_06_425581 432 43 is be VBZ 10_1101-2021_01_06_425581 432 44 the the DT 10_1101-2021_01_06_425581 432 45 author author NN 10_1101-2021_01_06_425581 432 46 / / SYM 10_1101-2021_01_06_425581 432 47 funder funder NN 10_1101-2021_01_06_425581 432 48 , , , 10_1101-2021_01_06_425581 432 49 who who WP 10_1101-2021_01_06_425581 432 50 has have VBZ 10_1101-2021_01_06_425581 432 51 granted grant VBN 10_1101-2021_01_06_425581 432 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 432 53 a a DT 10_1101-2021_01_06_425581 432 54 license license NN 10_1101-2021_01_06_425581 432 55 to to TO 10_1101-2021_01_06_425581 432 56 display display VB 10_1101-2021_01_06_425581 432 57 the the DT 10_1101-2021_01_06_425581 432 58 preprint preprint NN 10_1101-2021_01_06_425581 432 59 in in IN 10_1101-2021_01_06_425581 432 60 perpetuity perpetuity NN 10_1101-2021_01_06_425581 432 61 . . . 10_1101-2021_01_06_425581 433 1 It -PRON- PRP 10_1101-2021_01_06_425581 433 2 is be VBZ 10_1101-2021_01_06_425581 433 3 The the DT 10_1101-2021_01_06_425581 433 4 copyright copyright NN 10_1101-2021_01_06_425581 433 5 holder holder NN 10_1101-2021_01_06_425581 433 6 for for IN 10_1101-2021_01_06_425581 433 7 this this DT 10_1101-2021_01_06_425581 433 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 433 9 version version NN 10_1101-2021_01_06_425581 433 10 posted post VBD 10_1101-2021_01_06_425581 433 11 January January NNP 10_1101-2021_01_06_425581 433 12 8 8 CD 10_1101-2021_01_06_425581 433 13 , , , 10_1101-2021_01_06_425581 433 14 2021 2021 CD 10_1101-2021_01_06_425581 433 15 . . . 10_1101-2021_01_06_425581 433 16 ; ; : 10_1101-2021_01_06_425581 433 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 433 18 : : : 10_1101-2021_01_06_425581 433 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 433 20 preprint preprint NN 10_1101-2021_01_06_425581 433 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 433 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP 10_1101-2021_01_06_425581 433 23 .CC .CC NFP 10_1101-2021_01_06_425581 433 24 - - : 10_1101-2021_01_06_425581 433 25 BY BY NNP 10_1101-2021_01_06_425581 433 26 - - HYPH 10_1101-2021_01_06_425581 433 27 NC NC NNP 10_1101-2021_01_06_425581 433 28 4.0 4.0 CD 10_1101-2021_01_06_425581 433 29 International international JJ 10_1101-2021_01_06_425581 433 30 licensemade licensemade NN 10_1101-2021_01_06_425581 433 31 available available JJ 10_1101-2021_01_06_425581 433 32 under under IN 10_1101-2021_01_06_425581 433 33 a a DT 10_1101-2021_01_06_425581 433 34 ( ( -LRB- 10_1101-2021_01_06_425581 433 35 which which WDT 10_1101-2021_01_06_425581 433 36 was be VBD 10_1101-2021_01_06_425581 433 37 not not RB 10_1101-2021_01_06_425581 433 38 certified certify VBN 10_1101-2021_01_06_425581 433 39 by by IN 10_1101-2021_01_06_425581 433 40 peer peer NN 10_1101-2021_01_06_425581 433 41 review review NN 10_1101-2021_01_06_425581 433 42 ) ) -RRB- 10_1101-2021_01_06_425581 433 43 is be VBZ 10_1101-2021_01_06_425581 433 44 the the DT 10_1101-2021_01_06_425581 433 45 author author NN 10_1101-2021_01_06_425581 433 46 / / SYM 10_1101-2021_01_06_425581 433 47 funder funder NN 10_1101-2021_01_06_425581 433 48 , , , 10_1101-2021_01_06_425581 433 49 who who WP 10_1101-2021_01_06_425581 433 50 has have VBZ 10_1101-2021_01_06_425581 433 51 granted grant VBN 10_1101-2021_01_06_425581 433 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 433 53 a a DT 10_1101-2021_01_06_425581 433 54 license license NN 10_1101-2021_01_06_425581 433 55 to to TO 10_1101-2021_01_06_425581 433 56 display display VB 10_1101-2021_01_06_425581 433 57 the the DT 10_1101-2021_01_06_425581 433 58 preprint preprint NN 10_1101-2021_01_06_425581 433 59 in in IN 10_1101-2021_01_06_425581 433 60 perpetuity perpetuity NN 10_1101-2021_01_06_425581 433 61 . . . 10_1101-2021_01_06_425581 434 1 It -PRON- PRP 10_1101-2021_01_06_425581 434 2 is be VBZ 10_1101-2021_01_06_425581 434 3 The the DT 10_1101-2021_01_06_425581 434 4 copyright copyright NN 10_1101-2021_01_06_425581 434 5 holder holder NN 10_1101-2021_01_06_425581 434 6 for for IN 10_1101-2021_01_06_425581 434 7 this this DT 10_1101-2021_01_06_425581 434 8 preprintthis preprintthis NN 10_1101-2021_01_06_425581 434 9 version version NN 10_1101-2021_01_06_425581 434 10 posted post VBD 10_1101-2021_01_06_425581 434 11 January January NNP 10_1101-2021_01_06_425581 434 12 8 8 CD 10_1101-2021_01_06_425581 434 13 , , , 10_1101-2021_01_06_425581 434 14 2021 2021 CD 10_1101-2021_01_06_425581 434 15 . . . 10_1101-2021_01_06_425581 434 16 ; ; : 10_1101-2021_01_06_425581 434 17 https://doi.org/10.1101/2021.01.06.425581doi https://doi.org/10.1101/2021.01.06.425581doi ADD 10_1101-2021_01_06_425581 434 18 : : : 10_1101-2021_01_06_425581 434 19 bioRxiv biorxiv IN 10_1101-2021_01_06_425581 434 20 preprint preprint NN 10_1101-2021_01_06_425581 434 21 https://doi.org/10.1101/2021.01.06.425581 https://doi.org/10.1101/2021.01.06.425581 CD 10_1101-2021_01_06_425581 434 22 http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ NNP