id	sid	tid	token	lemma	pos
10_1101-2020_09_09_289074	1	1	Structural	Structural	NNP
10_1101-2020_09_09_289074	1	2	Genetics	Genetics	NNP
10_1101-2020_09_09_289074	1	3	of	of	IN
10_1101-2020_09_09_289074	1	4	circulating	circulate	VBG
10_1101-2020_09_09_289074	1	5	variants	variant	NNS
10_1101-2020_09_09_289074	1	6	affecting	affect	VBG
10_1101-2020_09_09_289074	1	7	the	the	DT
10_1101-2020_09_09_289074	1	8	SARS	SARS	NNP
10_1101-2020_09_09_289074	1	9	-	-	HYPH
10_1101-2020_09_09_289074	1	10	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	1	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	1	12	/	/	SYM
10_1101-2020_09_09_289074	1	13	human	human	JJ
10_1101-2020_09_09_289074	1	14	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	1	15	complex	complex	NN
10_1101-2020_09_09_289074	1	16	1	1	CD
10_1101-2020_09_09_289074	1	17	Structural	Structural	NNP
10_1101-2020_09_09_289074	1	18	Genetics	Genetics	NNPS
10_1101-2020_09_09_289074	1	19	of	of	IN
10_1101-2020_09_09_289074	1	20	circulating	circulate	VBG
10_1101-2020_09_09_289074	1	21	variants	variant	NNS
10_1101-2020_09_09_289074	1	22	affecting	affect	VBG
10_1101-2020_09_09_289074	1	23	the	the	DT
10_1101-2020_09_09_289074	1	24	SARS	SARS	NNP
10_1101-2020_09_09_289074	1	25	-	-	HYPH
10_1101-2020_09_09_289074	1	26	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	1	27	Spike	Spike	NNP
10_1101-2020_09_09_289074	1	28	/	/	SYM
10_1101-2020_09_09_289074	1	29	human	human	JJ
10_1101-2020_09_09_289074	1	30	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	1	31	complex	complex	JJ
10_1101-2020_09_09_289074	1	32	Francesco	Francesco	NNP
10_1101-2020_09_09_289074	1	33	Ortuso1,2	ortuso1,2	CD
10_1101-2020_09_09_289074	1	34	,	,	,
10_1101-2020_09_09_289074	1	35	Daniele	Daniele	NNP
10_1101-2020_09_09_289074	1	36	Mercatelli3	Mercatelli3	NNP
10_1101-2020_09_09_289074	1	37	,	,	,
10_1101-2020_09_09_289074	1	38	Pietro	Pietro	NNP
10_1101-2020_09_09_289074	1	39	Hiram	Hiram	NNP
10_1101-2020_09_09_289074	1	40	Guzzi4	Guzzi4	NNP
10_1101-2020_09_09_289074	1	41	,	,	,
10_1101-2020_09_09_289074	1	42	Federico	Federico	NNP
10_1101-2020_09_09_289074	1	43	Manuel	Manuel	NNP
10_1101-2020_09_09_289074	1	44	Giorgi3	Giorgi3	NNP
10_1101-2020_09_09_289074	1	45	,	,	,
10_1101-2020_09_09_289074	1	46	*	*	NFP
10_1101-2020_09_09_289074	1	47	1	1	CD
10_1101-2020_09_09_289074	1	48	Department	Department	NNP
10_1101-2020_09_09_289074	1	49	of	of	IN
10_1101-2020_09_09_289074	1	50	Health	Health	NNP
10_1101-2020_09_09_289074	1	51	Sciences	Sciences	NNPS
10_1101-2020_09_09_289074	1	52	,	,	,
10_1101-2020_09_09_289074	1	53	University	University	NNP
10_1101-2020_09_09_289074	1	54	“	"	``
10_1101-2020_09_09_289074	1	55	Magna	Magna	NNPS
10_1101-2020_09_09_289074	1	56	Græcia	Græcia	NNP
10_1101-2020_09_09_289074	1	57	”	"	''
10_1101-2020_09_09_289074	1	58	of	of	IN
10_1101-2020_09_09_289074	1	59	Catanzaro	Catanzaro	NNP
10_1101-2020_09_09_289074	1	60	,	,	,
10_1101-2020_09_09_289074	1	61	Catanzaro	Catanzaro	NNP
10_1101-2020_09_09_289074	1	62	,	,	,
10_1101-2020_09_09_289074	1	63	Italy	Italy	NNP
10_1101-2020_09_09_289074	1	64	2	2	CD
10_1101-2020_09_09_289074	1	65	Net4Science	Net4Science	NNP
10_1101-2020_09_09_289074	1	66	srl	srl	NN
10_1101-2020_09_09_289074	1	67	,	,	,
10_1101-2020_09_09_289074	1	68	c	c	NN
10_1101-2020_09_09_289074	1	69	/	/	SYM
10_1101-2020_09_09_289074	1	70	o	o	NNP
10_1101-2020_09_09_289074	1	71	University	University	NNP
10_1101-2020_09_09_289074	1	72	“	"	``
10_1101-2020_09_09_289074	1	73	Magna	Magna	NNPS
10_1101-2020_09_09_289074	1	74	Græcia	Græcia	NNP
10_1101-2020_09_09_289074	1	75	”	"	''
10_1101-2020_09_09_289074	1	76	of	of	IN
10_1101-2020_09_09_289074	1	77	Catanzaro	Catanzaro	NNP
10_1101-2020_09_09_289074	1	78	,	,	,
10_1101-2020_09_09_289074	1	79	Catanzaro	Catanzaro	NNP
10_1101-2020_09_09_289074	1	80	,	,	,
10_1101-2020_09_09_289074	1	81	Italy	Italy	NNP
10_1101-2020_09_09_289074	1	82	3	3	CD
10_1101-2020_09_09_289074	1	83	Department	Department	NNP
10_1101-2020_09_09_289074	1	84	of	of	IN
10_1101-2020_09_09_289074	1	85	Pharmacy	Pharmacy	NNP
10_1101-2020_09_09_289074	1	86	and	and	CC
10_1101-2020_09_09_289074	1	87	Biotechnology	Biotechnology	NNP
10_1101-2020_09_09_289074	1	88	,	,	,
10_1101-2020_09_09_289074	1	89	University	University	NNP
10_1101-2020_09_09_289074	1	90	of	of	IN
10_1101-2020_09_09_289074	1	91	Bologna	Bologna	NNPS
10_1101-2020_09_09_289074	1	92	,	,	,
10_1101-2020_09_09_289074	1	93	Bologna	Bologna	NNPS
10_1101-2020_09_09_289074	1	94	,	,	,
10_1101-2020_09_09_289074	1	95	Italy	Italy	NNP
10_1101-2020_09_09_289074	1	96	4	4	CD
10_1101-2020_09_09_289074	1	97	Department	Department	NNP
10_1101-2020_09_09_289074	1	98	of	of	IN
10_1101-2020_09_09_289074	1	99	Surgical	Surgical	NNP
10_1101-2020_09_09_289074	1	100	and	and	CC
10_1101-2020_09_09_289074	1	101	Medical	Medical	NNP
10_1101-2020_09_09_289074	1	102	Sciences	Sciences	NNPS
10_1101-2020_09_09_289074	1	103	,	,	,
10_1101-2020_09_09_289074	1	104	University	University	NNP
10_1101-2020_09_09_289074	1	105	“	"	``
10_1101-2020_09_09_289074	1	106	Magna	Magna	NNPS
10_1101-2020_09_09_289074	1	107	Græcia	Græcia	NNP
10_1101-2020_09_09_289074	1	108	”	"	''
10_1101-2020_09_09_289074	1	109	of	of	IN
10_1101-2020_09_09_289074	1	110	Catanzaro	Catanzaro	NNP
10_1101-2020_09_09_289074	1	111	,	,	,
10_1101-2020_09_09_289074	1	112	Catanzaro	Catanzaro	NNP
10_1101-2020_09_09_289074	1	113	,	,	,
10_1101-2020_09_09_289074	1	114	Italy	Italy	NNP
10_1101-2020_09_09_289074	1	115	*	*	NFP
10_1101-2020_09_09_289074	1	116	Corresponding	Corresponding	NNP
10_1101-2020_09_09_289074	1	117	author	author	NN
10_1101-2020_09_09_289074	1	118	E	e	NN
10_1101-2020_09_09_289074	1	119	-	-	NN
10_1101-2020_09_09_289074	1	120	mail	mail	NN
10_1101-2020_09_09_289074	1	121	:	:	:
10_1101-2020_09_09_289074	1	122	federico.giorgi@unibo.it	federico.giorgi@unibo.it	NNP
10_1101-2020_09_09_289074	1	123	(	(	-LRB-
10_1101-2020_09_09_289074	1	124	FMG	FMG	NNP
10_1101-2020_09_09_289074	1	125	)	)	-RRB-
10_1101-2020_09_09_289074	1	126	ORCIDs	ORCIDs	NNP
10_1101-2020_09_09_289074	1	127	Francesco	Francesco	NNP
10_1101-2020_09_09_289074	1	128	Ortuso	Ortuso	NNP
10_1101-2020_09_09_289074	1	129	:	:	:
10_1101-2020_09_09_289074	1	130	0000	0000	CD
10_1101-2020_09_09_289074	1	131	-	-	HYPH
10_1101-2020_09_09_289074	1	132	0001	0001	CD
10_1101-2020_09_09_289074	1	133	-	-	HYPH
10_1101-2020_09_09_289074	1	134	6235	6235	CD
10_1101-2020_09_09_289074	1	135	-	-	HYPH
10_1101-2020_09_09_289074	1	136	8161	8161	CD
10_1101-2020_09_09_289074	1	137	Daniele	Daniele	NNP
10_1101-2020_09_09_289074	1	138	Mercatelli	Mercatelli	NNP
10_1101-2020_09_09_289074	1	139	:	:	:
10_1101-2020_09_09_289074	1	140	0000	0000	CD
10_1101-2020_09_09_289074	1	141	-	-	HYPH
10_1101-2020_09_09_289074	1	142	0003	0003	CD
10_1101-2020_09_09_289074	1	143	-	-	HYPH
10_1101-2020_09_09_289074	1	144	3228	3228	CD
10_1101-2020_09_09_289074	1	145	-	-	HYPH
10_1101-2020_09_09_289074	1	146	0580	0580	CD
10_1101-2020_09_09_289074	1	147	Pietro	Pietro	NNP
10_1101-2020_09_09_289074	1	148	Hiram	Hiram	NNP
10_1101-2020_09_09_289074	1	149	Guzzi	Guzzi	NNP
10_1101-2020_09_09_289074	1	150	:	:	:
10_1101-2020_09_09_289074	1	151	0000	0000	CD
10_1101-2020_09_09_289074	1	152	-	-	HYPH
10_1101-2020_09_09_289074	1	153	0001	0001	CD
10_1101-2020_09_09_289074	1	154	-	-	HYPH
10_1101-2020_09_09_289074	1	155	5542	5542	CD
10_1101-2020_09_09_289074	1	156	-	-	HYPH
10_1101-2020_09_09_289074	1	157	2997	2997	CD
10_1101-2020_09_09_289074	1	158	Federico	Federico	NNP
10_1101-2020_09_09_289074	1	159	Manuel	Manuel	NNP
10_1101-2020_09_09_289074	1	160	Giorgi	Giorgi	NNP
10_1101-2020_09_09_289074	1	161	:	:	:
10_1101-2020_09_09_289074	1	162	0000	0000	CD
10_1101-2020_09_09_289074	1	163	-	-	HYPH
10_1101-2020_09_09_289074	1	164	0002	0002	CD
10_1101-2020_09_09_289074	1	165	-	-	HYPH
10_1101-2020_09_09_289074	1	166	7325	7325	CD
10_1101-2020_09_09_289074	1	167	-	-	SYM
10_1101-2020_09_09_289074	1	168	9908	9908	CD
10_1101-2020_09_09_289074	1	169	Classification	Classification	NNP
10_1101-2020_09_09_289074	1	170	Biophysics	Biophysics	NNPS
10_1101-2020_09_09_289074	1	171	and	and	CC
10_1101-2020_09_09_289074	1	172	Computational	Computational	NNP
10_1101-2020_09_09_289074	1	173	Biology	Biology	NNP
10_1101-2020_09_09_289074	1	174	Keywords	Keywords	NNP
10_1101-2020_09_09_289074	1	175	SARS	SARS	NNP
10_1101-2020_09_09_289074	1	176	-	-	HYPH
10_1101-2020_09_09_289074	1	177	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	1	178	,	,	,
10_1101-2020_09_09_289074	1	179	COVID-19	COVID-19	,
10_1101-2020_09_09_289074	1	180	,	,	,
10_1101-2020_09_09_289074	1	181	mutations	mutation	NNS
10_1101-2020_09_09_289074	1	182	,	,	,
10_1101-2020_09_09_289074	1	183	Spike	Spike	NNP
10_1101-2020_09_09_289074	1	184	,	,	,
10_1101-2020_09_09_289074	1	185	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	1	186	Author	Author	NNP
10_1101-2020_09_09_289074	1	187	Contributions	Contributions	NNPS
10_1101-2020_09_09_289074	1	188	FMG	FMG	NNP
10_1101-2020_09_09_289074	1	189	,	,	,
10_1101-2020_09_09_289074	1	190	PHG	PHG	NNP
10_1101-2020_09_09_289074	1	191	and	and	CC
10_1101-2020_09_09_289074	1	192	FO	FO	NNP
10_1101-2020_09_09_289074	1	193	designed	design	VBD
10_1101-2020_09_09_289074	1	194	the	the	DT
10_1101-2020_09_09_289074	1	195	study	study	NN
10_1101-2020_09_09_289074	1	196	.	.	.
10_1101-2020_09_09_289074	2	1	FO	FO	NNP
10_1101-2020_09_09_289074	2	2	designed	design	VBD
10_1101-2020_09_09_289074	2	3	and	and	CC
10_1101-2020_09_09_289074	2	4	performed	perform	VBD
10_1101-2020_09_09_289074	2	5	the	the	DT
10_1101-2020_09_09_289074	2	6	structural	structural	JJ
10_1101-2020_09_09_289074	2	7	analysis	analysis	NN
10_1101-2020_09_09_289074	2	8	.	.	.
10_1101-2020_09_09_289074	3	1	FMG	FMG	NNP
10_1101-2020_09_09_289074	3	2	designed	design	VBD
10_1101-2020_09_09_289074	3	3	the	the	DT
10_1101-2020_09_09_289074	3	4	genetics	genetic	NNS
10_1101-2020_09_09_289074	3	5	analysis	analysis	NN
10_1101-2020_09_09_289074	3	6	.	.	.
10_1101-2020_09_09_289074	4	1	FMG	FMG	NNP
10_1101-2020_09_09_289074	4	2	and	and	CC
10_1101-2020_09_09_289074	4	3	DM	DM	NNP
10_1101-2020_09_09_289074	4	4	performed	perform	VBD
10_1101-2020_09_09_289074	4	5	the	the	DT
10_1101-2020_09_09_289074	4	6	genetics	genetic	NNS
10_1101-2020_09_09_289074	4	7	analysis	analysis	NN
10_1101-2020_09_09_289074	4	8	.	.	.
10_1101-2020_09_09_289074	5	1	FMG	FMG	NNP
10_1101-2020_09_09_289074	5	2	financially	financially	RB
10_1101-2020_09_09_289074	5	3	supported	support	VBD
10_1101-2020_09_09_289074	5	4	the	the	DT
10_1101-2020_09_09_289074	5	5	study	study	NN
10_1101-2020_09_09_289074	5	6	.	.	.
10_1101-2020_09_09_289074	6	1	PHG	PHG	NNP
10_1101-2020_09_09_289074	6	2	drafted	draft	VBD
10_1101-2020_09_09_289074	6	3	the	the	DT
10_1101-2020_09_09_289074	6	4	manuscript	manuscript	NN
10_1101-2020_09_09_289074	6	5	and	and	CC
10_1101-2020_09_09_289074	6	6	performed	perform	VBN
10_1101-2020_09_09_289074	6	7	literature	literature	NN
10_1101-2020_09_09_289074	6	8	search	search	NN
10_1101-2020_09_09_289074	6	9	.	.	.
10_1101-2020_09_09_289074	7	1	All	all	DT
10_1101-2020_09_09_289074	7	2	authors	author	NNS
10_1101-2020_09_09_289074	7	3	contributed	contribute	VBD
10_1101-2020_09_09_289074	7	4	to	to	IN
10_1101-2020_09_09_289074	7	5	the	the	DT
10_1101-2020_09_09_289074	7	6	writing	writing	NN
10_1101-2020_09_09_289074	7	7	of	of	IN
10_1101-2020_09_09_289074	7	8	the	the	DT
10_1101-2020_09_09_289074	7	9	final	final	JJ
10_1101-2020_09_09_289074	7	10	version	version	NN
10_1101-2020_09_09_289074	7	11	of	of	IN
10_1101-2020_09_09_289074	7	12	the	the	DT
10_1101-2020_09_09_289074	7	13	manuscript	manuscript	NN
10_1101-2020_09_09_289074	7	14	.	.	.
10_1101-2020_09_09_289074	8	1	Abstract	abstract	JJ
10_1101-2020_09_09_289074	8	2	.CC	.CC	NFP
10_1101-2020_09_09_289074	8	3	-	-	:
10_1101-2020_09_09_289074	8	4	BY	by	IN
10_1101-2020_09_09_289074	8	5	-	-	HYPH
10_1101-2020_09_09_289074	8	6	NC	NC	NNP
10_1101-2020_09_09_289074	8	7	-	-	HYPH
10_1101-2020_09_09_289074	8	8	ND	ND	NNP
10_1101-2020_09_09_289074	8	9	4.0	4.0	CD
10_1101-2020_09_09_289074	8	10	International	International	NNP
10_1101-2020_09_09_289074	8	11	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	8	12	under	under	IN
10_1101-2020_09_09_289074	8	13	a	a	DT
10_1101-2020_09_09_289074	8	14	(	(	-LRB-
10_1101-2020_09_09_289074	8	15	which	which	WDT
10_1101-2020_09_09_289074	8	16	was	be	VBD
10_1101-2020_09_09_289074	8	17	not	not	RB
10_1101-2020_09_09_289074	8	18	certified	certify	VBN
10_1101-2020_09_09_289074	8	19	by	by	IN
10_1101-2020_09_09_289074	8	20	peer	peer	NN
10_1101-2020_09_09_289074	8	21	review	review	NN
10_1101-2020_09_09_289074	8	22	)	)	-RRB-
10_1101-2020_09_09_289074	8	23	is	be	VBZ
10_1101-2020_09_09_289074	8	24	the	the	DT
10_1101-2020_09_09_289074	8	25	author	author	NN
10_1101-2020_09_09_289074	8	26	/	/	SYM
10_1101-2020_09_09_289074	8	27	funder	funder	NN
10_1101-2020_09_09_289074	8	28	,	,	,
10_1101-2020_09_09_289074	8	29	who	who	WP
10_1101-2020_09_09_289074	8	30	has	have	VBZ
10_1101-2020_09_09_289074	8	31	granted	grant	VBN
10_1101-2020_09_09_289074	8	32	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	8	33	a	a	DT
10_1101-2020_09_09_289074	8	34	license	license	NN
10_1101-2020_09_09_289074	8	35	to	to	TO
10_1101-2020_09_09_289074	8	36	display	display	VB
10_1101-2020_09_09_289074	8	37	the	the	DT
10_1101-2020_09_09_289074	8	38	preprint	preprint	NN
10_1101-2020_09_09_289074	8	39	in	in	IN
10_1101-2020_09_09_289074	8	40	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	8	41	.	.	.
10_1101-2020_09_09_289074	9	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	9	2	is	be	VBZ
10_1101-2020_09_09_289074	9	3	made	make	VBN
10_1101-2020_09_09_289074	9	4	The	the	DT
10_1101-2020_09_09_289074	9	5	copyright	copyright	NN
10_1101-2020_09_09_289074	9	6	holder	holder	NN
10_1101-2020_09_09_289074	9	7	for	for	IN
10_1101-2020_09_09_289074	9	8	this	this	DT
10_1101-2020_09_09_289074	9	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	9	10	version	version	NN
10_1101-2020_09_09_289074	9	11	posted	post	VBD
10_1101-2020_09_09_289074	9	12	January	January	NNP
10_1101-2020_09_09_289074	9	13	5	5	CD
10_1101-2020_09_09_289074	9	14	,	,	,
10_1101-2020_09_09_289074	9	15	2021	2021	CD
10_1101-2020_09_09_289074	9	16	.	.	.
10_1101-2020_09_09_289074	9	17	;	;	:
10_1101-2020_09_09_289074	9	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	9	19	:	:	:
10_1101-2020_09_09_289074	9	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	9	21	preprint	preprint	NN
10_1101-2020_09_09_289074	9	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	9	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NNP
10_1101-2020_09_09_289074	9	24	2	2	CD
10_1101-2020_09_09_289074	9	25	SARS	SARS	NNP
10_1101-2020_09_09_289074	9	26	-	-	HYPH
10_1101-2020_09_09_289074	9	27	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	9	28	entry	entry	NN
10_1101-2020_09_09_289074	9	29	in	in	IN
10_1101-2020_09_09_289074	9	30	human	human	JJ
10_1101-2020_09_09_289074	9	31	cells	cell	NNS
10_1101-2020_09_09_289074	9	32	is	be	VBZ
10_1101-2020_09_09_289074	9	33	mediated	mediate	VBN
10_1101-2020_09_09_289074	9	34	by	by	IN
10_1101-2020_09_09_289074	9	35	the	the	DT
10_1101-2020_09_09_289074	9	36	interaction	interaction	NN
10_1101-2020_09_09_289074	9	37	between	between	IN
10_1101-2020_09_09_289074	9	38	the	the	DT
10_1101-2020_09_09_289074	9	39	viral	viral	JJ
10_1101-2020_09_09_289074	9	40	Spike	spike	JJ
10_1101-2020_09_09_289074	9	41	protein	protein	NN
10_1101-2020_09_09_289074	9	42	and	and	CC
10_1101-2020_09_09_289074	9	43	the	the	DT
10_1101-2020_09_09_289074	9	44	human	human	JJ
10_1101-2020_09_09_289074	9	45	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	9	46	receptor	receptor	NN
10_1101-2020_09_09_289074	9	47	.	.	.
10_1101-2020_09_09_289074	10	1	This	this	DT
10_1101-2020_09_09_289074	10	2	mechanism	mechanism	NN
10_1101-2020_09_09_289074	10	3	evolved	evolve	VBD
10_1101-2020_09_09_289074	10	4	from	from	IN
10_1101-2020_09_09_289074	10	5	the	the	DT
10_1101-2020_09_09_289074	10	6	ancestor	ancestor	NN
10_1101-2020_09_09_289074	10	7	bat	bat	NN
10_1101-2020_09_09_289074	10	8	coronavirus	coronavirus	NNP
10_1101-2020_09_09_289074	10	9	and	and	CC
10_1101-2020_09_09_289074	10	10	is	be	VBZ
10_1101-2020_09_09_289074	10	11	currently	currently	RB
10_1101-2020_09_09_289074	10	12	one	one	CD
10_1101-2020_09_09_289074	10	13	of	of	IN
10_1101-2020_09_09_289074	10	14	the	the	DT
10_1101-2020_09_09_289074	10	15	main	main	JJ
10_1101-2020_09_09_289074	10	16	targets	target	NNS
10_1101-2020_09_09_289074	10	17	for	for	IN
10_1101-2020_09_09_289074	10	18	antiviral	antiviral	JJ
10_1101-2020_09_09_289074	10	19	strategies	strategy	NNS
10_1101-2020_09_09_289074	10	20	.	.	.
10_1101-2020_09_09_289074	11	1	However	however	RB
10_1101-2020_09_09_289074	11	2	,	,	,
10_1101-2020_09_09_289074	11	3	there	there	EX
10_1101-2020_09_09_289074	11	4	currently	currently	RB
10_1101-2020_09_09_289074	11	5	exist	exist	VBP
10_1101-2020_09_09_289074	11	6	several	several	JJ
10_1101-2020_09_09_289074	11	7	Spike	Spike	NNP
10_1101-2020_09_09_289074	11	8	protein	protein	NN
10_1101-2020_09_09_289074	11	9	variants	variant	NNS
10_1101-2020_09_09_289074	11	10	in	in	IN
10_1101-2020_09_09_289074	11	11	the	the	DT
10_1101-2020_09_09_289074	11	12	SARS	SARS	NNP
10_1101-2020_09_09_289074	11	13	-	-	HYPH
10_1101-2020_09_09_289074	11	14	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	11	15	population	population	NN
10_1101-2020_09_09_289074	11	16	as	as	IN
10_1101-2020_09_09_289074	11	17	the	the	DT
10_1101-2020_09_09_289074	11	18	result	result	NN
10_1101-2020_09_09_289074	11	19	of	of	IN
10_1101-2020_09_09_289074	11	20	mutations	mutation	NNS
10_1101-2020_09_09_289074	11	21	,	,	,
10_1101-2020_09_09_289074	11	22	and	and	CC
10_1101-2020_09_09_289074	11	23	it	-PRON-	PRP
10_1101-2020_09_09_289074	11	24	is	be	VBZ
10_1101-2020_09_09_289074	11	25	unclear	unclear	JJ
10_1101-2020_09_09_289074	11	26	if	if	IN
10_1101-2020_09_09_289074	11	27	these	these	DT
10_1101-2020_09_09_289074	11	28	variants	variant	NNS
10_1101-2020_09_09_289074	11	29	may	may	MD
10_1101-2020_09_09_289074	11	30	exert	exert	VB
10_1101-2020_09_09_289074	11	31	a	a	DT
10_1101-2020_09_09_289074	11	32	specific	specific	JJ
10_1101-2020_09_09_289074	11	33	effect	effect	NN
10_1101-2020_09_09_289074	11	34	on	on	IN
10_1101-2020_09_09_289074	11	35	the	the	DT
10_1101-2020_09_09_289074	11	36	affinity	affinity	NN
10_1101-2020_09_09_289074	11	37	with	with	IN
10_1101-2020_09_09_289074	11	38	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	11	39	which	which	WDT
10_1101-2020_09_09_289074	11	40	,	,	,
10_1101-2020_09_09_289074	11	41	in	in	IN
10_1101-2020_09_09_289074	11	42	turn	turn	NN
10_1101-2020_09_09_289074	11	43	,	,	,
10_1101-2020_09_09_289074	11	44	is	be	VBZ
10_1101-2020_09_09_289074	11	45	also	also	RB
10_1101-2020_09_09_289074	11	46	characterized	characterize	VBN
10_1101-2020_09_09_289074	11	47	by	by	IN
10_1101-2020_09_09_289074	11	48	multiple	multiple	JJ
10_1101-2020_09_09_289074	11	49	alleles	allele	NNS
10_1101-2020_09_09_289074	11	50	in	in	IN
10_1101-2020_09_09_289074	11	51	the	the	DT
10_1101-2020_09_09_289074	11	52	human	human	JJ
10_1101-2020_09_09_289074	11	53	population	population	NN
10_1101-2020_09_09_289074	11	54	.	.	.
10_1101-2020_09_09_289074	12	1	In	in	IN
10_1101-2020_09_09_289074	12	2	the	the	DT
10_1101-2020_09_09_289074	12	3	current	current	JJ
10_1101-2020_09_09_289074	12	4	study	study	NN
10_1101-2020_09_09_289074	12	5	,	,	,
10_1101-2020_09_09_289074	12	6	the	the	DT
10_1101-2020_09_09_289074	12	7	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	12	8	analysis	analysis	NN
10_1101-2020_09_09_289074	12	9	,	,	,
10_1101-2020_09_09_289074	12	10	originally	originally	RB
10_1101-2020_09_09_289074	12	11	developed	develop	VBN
10_1101-2020_09_09_289074	12	12	for	for	IN
10_1101-2020_09_09_289074	12	13	highlighting	highlight	VBG
10_1101-2020_09_09_289074	12	14	host	host	NN
10_1101-2020_09_09_289074	12	15	-	-	HYPH
10_1101-2020_09_09_289074	12	16	guest	guest	JJ
10_1101-2020_09_09_289074	12	17	interaction	interaction	NN
10_1101-2020_09_09_289074	12	18	features	feature	NNS
10_1101-2020_09_09_289074	12	19	,	,	,
10_1101-2020_09_09_289074	12	20	has	have	VBZ
10_1101-2020_09_09_289074	12	21	been	be	VBN
10_1101-2020_09_09_289074	12	22	applied	apply	VBN
10_1101-2020_09_09_289074	12	23	to	to	TO
10_1101-2020_09_09_289074	12	24	define	define	VB
10_1101-2020_09_09_289074	12	25	the	the	DT
10_1101-2020_09_09_289074	12	26	key	key	JJ
10_1101-2020_09_09_289074	12	27	amino	amino	NN
10_1101-2020_09_09_289074	12	28	acids	acid	NNS
10_1101-2020_09_09_289074	12	29	responsible	responsible	JJ
10_1101-2020_09_09_289074	12	30	for	for	IN
10_1101-2020_09_09_289074	12	31	the	the	DT
10_1101-2020_09_09_289074	12	32	Spike	Spike	NNP
10_1101-2020_09_09_289074	12	33	/	/	SYM
10_1101-2020_09_09_289074	12	34	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	12	35	molecular	molecular	JJ
10_1101-2020_09_09_289074	12	36	recognition	recognition	NN
10_1101-2020_09_09_289074	12	37	,	,	,
10_1101-2020_09_09_289074	12	38	using	use	VBG
10_1101-2020_09_09_289074	12	39	four	four	CD
10_1101-2020_09_09_289074	12	40	different	different	JJ
10_1101-2020_09_09_289074	12	41	crystallographic	crystallographic	JJ
10_1101-2020_09_09_289074	12	42	structures	structure	NNS
10_1101-2020_09_09_289074	12	43	.	.	.
10_1101-2020_09_09_289074	13	1	Then	then	RB
10_1101-2020_09_09_289074	13	2	,	,	,
10_1101-2020_09_09_289074	13	3	we	-PRON-	PRP
10_1101-2020_09_09_289074	13	4	intersected	intersect	VBD
10_1101-2020_09_09_289074	13	5	these	these	DT
10_1101-2020_09_09_289074	13	6	structural	structural	JJ
10_1101-2020_09_09_289074	13	7	results	result	NNS
10_1101-2020_09_09_289074	13	8	with	with	IN
10_1101-2020_09_09_289074	13	9	the	the	DT
10_1101-2020_09_09_289074	13	10	current	current	JJ
10_1101-2020_09_09_289074	13	11	mutational	mutational	JJ
10_1101-2020_09_09_289074	13	12	status	status	NN
10_1101-2020_09_09_289074	13	13	,	,	,
10_1101-2020_09_09_289074	13	14	based	base	VBN
10_1101-2020_09_09_289074	13	15	on	on	IN
10_1101-2020_09_09_289074	13	16	more	more	JJR
10_1101-2020_09_09_289074	13	17	than	than	IN
10_1101-2020_09_09_289074	13	18	295,000	295,000	CD
10_1101-2020_09_09_289074	13	19	sequenced	sequence	VBN
10_1101-2020_09_09_289074	13	20	cases	case	NNS
10_1101-2020_09_09_289074	13	21	,	,	,
10_1101-2020_09_09_289074	13	22	in	in	IN
10_1101-2020_09_09_289074	13	23	the	the	DT
10_1101-2020_09_09_289074	13	24	SARS	SARS	NNP
10_1101-2020_09_09_289074	13	25	-	-	HYPH
10_1101-2020_09_09_289074	13	26	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	13	27	population	population	NN
10_1101-2020_09_09_289074	13	28	.	.	.
10_1101-2020_09_09_289074	14	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	14	2	identified	identify	VBD
10_1101-2020_09_09_289074	14	3	several	several	JJ
10_1101-2020_09_09_289074	14	4	Spike	Spike	NNP
10_1101-2020_09_09_289074	14	5	mutations	mutation	NNS
10_1101-2020_09_09_289074	14	6	interacting	interact	VBG
10_1101-2020_09_09_289074	14	7	with	with	IN
10_1101-2020_09_09_289074	14	8	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	14	9	and	and	CC
10_1101-2020_09_09_289074	14	10	mutated	mutate	VBD
10_1101-2020_09_09_289074	14	11	in	in	IN
10_1101-2020_09_09_289074	14	12	at	at	RB
10_1101-2020_09_09_289074	14	13	least	least	RBS
10_1101-2020_09_09_289074	14	14	20	20	CD
10_1101-2020_09_09_289074	14	15	distinct	distinct	JJ
10_1101-2020_09_09_289074	14	16	patients	patient	NNS
10_1101-2020_09_09_289074	14	17	:	:	:
10_1101-2020_09_09_289074	14	18	S477N	S477N	NNP
10_1101-2020_09_09_289074	14	19	,	,	,
10_1101-2020_09_09_289074	14	20	N439	N439	NNP
10_1101-2020_09_09_289074	14	21	K	K	NNP
10_1101-2020_09_09_289074	14	22	,	,	,
10_1101-2020_09_09_289074	14	23	N501Y	N501Y	NNP
10_1101-2020_09_09_289074	14	24	,	,	,
10_1101-2020_09_09_289074	14	25	Y453F	Y453F	NNP
10_1101-2020_09_09_289074	14	26	,	,	,
10_1101-2020_09_09_289074	14	27	E484	E484	NNP
10_1101-2020_09_09_289074	14	28	K	K	NNP
10_1101-2020_09_09_289074	14	29	,	,	,
10_1101-2020_09_09_289074	14	30	K417N	K417N	NNP
10_1101-2020_09_09_289074	14	31	,	,	,
10_1101-2020_09_09_289074	14	32	S477I	S477I	NNP
10_1101-2020_09_09_289074	14	33	and	and	CC
10_1101-2020_09_09_289074	14	34	G476S.	G476S.	NNS
10_1101-2020_09_09_289074	15	1	Among	among	IN
10_1101-2020_09_09_289074	15	2	these	these	DT
10_1101-2020_09_09_289074	15	3	,	,	,
10_1101-2020_09_09_289074	15	4	mutation	mutation	NN
10_1101-2020_09_09_289074	15	5	N501Y	n501y	CD
10_1101-2020_09_09_289074	15	6	in	in	IN
10_1101-2020_09_09_289074	15	7	particular	particular	JJ
10_1101-2020_09_09_289074	15	8	is	be	VBZ
10_1101-2020_09_09_289074	15	9	one	one	CD
10_1101-2020_09_09_289074	15	10	of	of	IN
10_1101-2020_09_09_289074	15	11	the	the	DT
10_1101-2020_09_09_289074	15	12	events	event	NNS
10_1101-2020_09_09_289074	15	13	characterizing	characterize	VBG
10_1101-2020_09_09_289074	15	14	SARS	SARS	NNP
10_1101-2020_09_09_289074	15	15	-	-	HYPH
10_1101-2020_09_09_289074	15	16	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	15	17	lineage	lineage	NN
10_1101-2020_09_09_289074	15	18	B.1.1.7	B.1.1.7	NNP
10_1101-2020_09_09_289074	15	19	,	,	,
10_1101-2020_09_09_289074	15	20	which	which	WDT
10_1101-2020_09_09_289074	15	21	has	have	VBZ
10_1101-2020_09_09_289074	15	22	recently	recently	RB
10_1101-2020_09_09_289074	15	23	risen	rise	VBN
10_1101-2020_09_09_289074	15	24	in	in	IN
10_1101-2020_09_09_289074	15	25	frequency	frequency	NN
10_1101-2020_09_09_289074	15	26	in	in	IN
10_1101-2020_09_09_289074	15	27	Europe	Europe	NNP
10_1101-2020_09_09_289074	15	28	.	.	.
10_1101-2020_09_09_289074	16	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	16	2	also	also	RB
10_1101-2020_09_09_289074	16	3	identified	identify	VBD
10_1101-2020_09_09_289074	16	4	five	five	CD
10_1101-2020_09_09_289074	16	5	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	16	6	rare	rare	JJ
10_1101-2020_09_09_289074	16	7	variants	variant	NNS
10_1101-2020_09_09_289074	16	8	that	that	WDT
10_1101-2020_09_09_289074	16	9	may	may	MD
10_1101-2020_09_09_289074	16	10	affect	affect	VB
10_1101-2020_09_09_289074	16	11	interaction	interaction	NN
10_1101-2020_09_09_289074	16	12	with	with	IN
10_1101-2020_09_09_289074	16	13	Spike	Spike	NNP
10_1101-2020_09_09_289074	16	14	and	and	CC
10_1101-2020_09_09_289074	16	15	susceptibility	susceptibility	NN
10_1101-2020_09_09_289074	16	16	to	to	TO
10_1101-2020_09_09_289074	16	17	infection	infection	NN
10_1101-2020_09_09_289074	16	18	:	:	:
10_1101-2020_09_09_289074	16	19	S19P	s19p	NN
10_1101-2020_09_09_289074	16	20	,	,	,
10_1101-2020_09_09_289074	16	21	E37	E37	NNP
10_1101-2020_09_09_289074	16	22	K	K	NNP
10_1101-2020_09_09_289074	16	23	,	,	,
10_1101-2020_09_09_289074	16	24	M82I	M82I	NNP
10_1101-2020_09_09_289074	16	25	,	,	,
10_1101-2020_09_09_289074	16	26	E329	E329	NNP
10_1101-2020_09_09_289074	16	27	G	g	NN
10_1101-2020_09_09_289074	16	28	and	and	CC
10_1101-2020_09_09_289074	16	29	G352V.	g352v.	NN
10_1101-2020_09_09_289074	17	1	Significance	significance	NN
10_1101-2020_09_09_289074	17	2	Statement	Statement	NNP
10_1101-2020_09_09_289074	17	3	We	-PRON-	PRP
10_1101-2020_09_09_289074	17	4	developed	develop	VBD
10_1101-2020_09_09_289074	17	5	a	a	DT
10_1101-2020_09_09_289074	17	6	method	method	NN
10_1101-2020_09_09_289074	17	7	to	to	TO
10_1101-2020_09_09_289074	17	8	identify	identify	VB
10_1101-2020_09_09_289074	17	9	key	key	JJ
10_1101-2020_09_09_289074	17	10	amino	amino	JJ
10_1101-2020_09_09_289074	17	11	acids	acid	NNS
10_1101-2020_09_09_289074	17	12	responsible	responsible	JJ
10_1101-2020_09_09_289074	17	13	for	for	IN
10_1101-2020_09_09_289074	17	14	the	the	DT
10_1101-2020_09_09_289074	17	15	initial	initial	JJ
10_1101-2020_09_09_289074	17	16	interaction	interaction	NN
10_1101-2020_09_09_289074	17	17	between	between	IN
10_1101-2020_09_09_289074	17	18	SARS	SARS	NNP
10_1101-2020_09_09_289074	17	19	-	-	HYPH
10_1101-2020_09_09_289074	17	20	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	17	21	(	(	-LRB-
10_1101-2020_09_09_289074	17	22	the	the	DT
10_1101-2020_09_09_289074	17	23	COVID-19	COVID-19	NNP
10_1101-2020_09_09_289074	17	24	virus	virus	NN
10_1101-2020_09_09_289074	17	25	)	)	-RRB-
10_1101-2020_09_09_289074	17	26	and	and	CC
10_1101-2020_09_09_289074	17	27	human	human	JJ
10_1101-2020_09_09_289074	17	28	cells	cell	NNS
10_1101-2020_09_09_289074	17	29	,	,	,
10_1101-2020_09_09_289074	17	30	through	through	IN
10_1101-2020_09_09_289074	17	31	the	the	DT
10_1101-2020_09_09_289074	17	32	analysis	analysis	NN
10_1101-2020_09_09_289074	17	33	of	of	IN
10_1101-2020_09_09_289074	17	34	Spike	Spike	NNP
10_1101-2020_09_09_289074	17	35	/	/	SYM
10_1101-2020_09_09_289074	17	36	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	17	37	complexes	complex	NNS
10_1101-2020_09_09_289074	17	38	.	.	.
10_1101-2020_09_09_289074	18	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	18	2	further	further	RB
10_1101-2020_09_09_289074	18	3	identified	identify	VBD
10_1101-2020_09_09_289074	18	4	which	which	WDT
10_1101-2020_09_09_289074	18	5	of	of	IN
10_1101-2020_09_09_289074	18	6	these	these	DT
10_1101-2020_09_09_289074	18	7	amino	amino	JJ
10_1101-2020_09_09_289074	18	8	acids	acid	NNS
10_1101-2020_09_09_289074	18	9	show	show	VBP
10_1101-2020_09_09_289074	18	10	variants	variant	NNS
10_1101-2020_09_09_289074	18	11	in	in	IN
10_1101-2020_09_09_289074	18	12	the	the	DT
10_1101-2020_09_09_289074	18	13	viral	viral	JJ
10_1101-2020_09_09_289074	18	14	and	and	CC
10_1101-2020_09_09_289074	18	15	human	human	JJ
10_1101-2020_09_09_289074	18	16	populations	population	NNS
10_1101-2020_09_09_289074	18	17	.	.	.
10_1101-2020_09_09_289074	19	1	Our	-PRON-	PRP$
10_1101-2020_09_09_289074	19	2	results	result	NNS
10_1101-2020_09_09_289074	19	3	will	will	MD
10_1101-2020_09_09_289074	19	4	facilitate	facilitate	VB
10_1101-2020_09_09_289074	19	5	scientists	scientist	NNS
10_1101-2020_09_09_289074	19	6	and	and	CC
10_1101-2020_09_09_289074	19	7	clinicians	clinician	NNS
10_1101-2020_09_09_289074	19	8	alike	alike	RB
10_1101-2020_09_09_289074	19	9	in	in	IN
10_1101-2020_09_09_289074	19	10	identifying	identify	VBG
10_1101-2020_09_09_289074	19	11	the	the	DT
10_1101-2020_09_09_289074	19	12	possible	possible	JJ
10_1101-2020_09_09_289074	19	13	role	role	NN
10_1101-2020_09_09_289074	19	14	of	of	IN
10_1101-2020_09_09_289074	19	15	present	present	JJ
10_1101-2020_09_09_289074	19	16	and	and	CC
10_1101-2020_09_09_289074	19	17	future	future	JJ
10_1101-2020_09_09_289074	19	18	Spike	Spike	NNP
10_1101-2020_09_09_289074	19	19	and	and	CC
10_1101-2020_09_09_289074	19	20	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	19	21	sequence	sequence	NN
10_1101-2020_09_09_289074	19	22	variants	variant	NNS
10_1101-2020_09_09_289074	19	23	in	in	IN
10_1101-2020_09_09_289074	19	24	cell	cell	NN
10_1101-2020_09_09_289074	19	25	entry	entry	NN
10_1101-2020_09_09_289074	19	26	and	and	CC
10_1101-2020_09_09_289074	19	27	general	general	JJ
10_1101-2020_09_09_289074	19	28	susceptibility	susceptibility	NN
10_1101-2020_09_09_289074	19	29	to	to	IN
10_1101-2020_09_09_289074	19	30	infection	infection	NN
10_1101-2020_09_09_289074	19	31	.	.	.
10_1101-2020_09_09_289074	20	1	Abbreviations	abbreviation	NNS
10_1101-2020_09_09_289074	20	2	AA	AA	NNP
10_1101-2020_09_09_289074	20	3	:	:	:
10_1101-2020_09_09_289074	20	4	amino	amino	NN
10_1101-2020_09_09_289074	20	5	acid	acid	NN
10_1101-2020_09_09_289074	20	6	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	20	7	:	:	:
10_1101-2020_09_09_289074	20	8	Angiotensin	Angiotensin	NNP
10_1101-2020_09_09_289074	20	9	-	-	HYPH
10_1101-2020_09_09_289074	20	10	Converting	Converting	NNP
10_1101-2020_09_09_289074	20	11	Enzyme	Enzyme	NNPS
10_1101-2020_09_09_289074	20	12	2	2	CD
10_1101-2020_09_09_289074	20	13	COVID-19	COVID-19	,
10_1101-2020_09_09_289074	20	14	:	:	:
10_1101-2020_09_09_289074	20	15	Coronavirus	Coronavirus	NNP
10_1101-2020_09_09_289074	20	16	Disease	Disease	NNP
10_1101-2020_09_09_289074	20	17	2019	2019	CD
10_1101-2020_09_09_289074	20	18	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	20	19	:	:	:
10_1101-2020_09_09_289074	20	20	Grid	Grid	NNP
10_1101-2020_09_09_289074	20	21	Based	Based	NNP
10_1101-2020_09_09_289074	20	22	Pharmacophore	Pharmacophore	NNP
10_1101-2020_09_09_289074	20	23	Model	Model	NNP
10_1101-2020_09_09_289074	20	24	IEP	IEP	NNP
10_1101-2020_09_09_289074	20	25	:	:	:
10_1101-2020_09_09_289074	20	26	Interaction	Interaction	NNP
10_1101-2020_09_09_289074	20	27	Energy	Energy	NNP
10_1101-2020_09_09_289074	20	28	point	point	NN
10_1101-2020_09_09_289074	20	29	MIFs	mif	NNS
10_1101-2020_09_09_289074	20	30	:	:	:
10_1101-2020_09_09_289074	20	31	Molecular	Molecular	NNP
10_1101-2020_09_09_289074	20	32	Interaction	Interaction	NNP
10_1101-2020_09_09_289074	20	33	Fields	Fields	NNPS
10_1101-2020_09_09_289074	20	34	ORF	ORF	NNP
10_1101-2020_09_09_289074	20	35	:	:	:
10_1101-2020_09_09_289074	20	36	Open	open	JJ
10_1101-2020_09_09_289074	20	37	Reading	Reading	NNP
10_1101-2020_09_09_289074	20	38	Frame	Frame	NNP
10_1101-2020_09_09_289074	20	39	PDB	pdb	NN
10_1101-2020_09_09_289074	20	40	:	:	:
10_1101-2020_09_09_289074	20	41	Protein	Protein	NNP
10_1101-2020_09_09_289074	20	42	Data	Data	NNPS
10_1101-2020_09_09_289074	20	43	Bank	Bank	NNP
10_1101-2020_09_09_289074	20	44	RBD	RBD	NNP
10_1101-2020_09_09_289074	20	45	:	:	:
10_1101-2020_09_09_289074	20	46	Spike	Spike	NNP
10_1101-2020_09_09_289074	20	47	Receptor	Receptor	NNP
10_1101-2020_09_09_289074	20	48	Binding	Binding	NNP
10_1101-2020_09_09_289074	20	49	Domain	Domain	NNP
10_1101-2020_09_09_289074	20	50	with	with	IN
10_1101-2020_09_09_289074	20	51	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	20	52	RMSd	RMSd	NNS
10_1101-2020_09_09_289074	20	53	:	:	:
10_1101-2020_09_09_289074	20	54	Root	Root	NNP
10_1101-2020_09_09_289074	20	55	Mean	Mean	NNP
10_1101-2020_09_09_289074	20	56	Square	Square	NNP
10_1101-2020_09_09_289074	20	57	deviation	deviation	NN
10_1101-2020_09_09_289074	20	58	SARS	SARS	NNP
10_1101-2020_09_09_289074	20	59	-	-	HYPH
10_1101-2020_09_09_289074	20	60	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	20	61	:	:	:
10_1101-2020_09_09_289074	20	62	Severe	Severe	NNP
10_1101-2020_09_09_289074	20	63	Acute	Acute	NNP
10_1101-2020_09_09_289074	20	64	Respiratory	respiratory	JJ
10_1101-2020_09_09_289074	20	65	Syndrome	syndrome	NN
10_1101-2020_09_09_289074	20	66	Coronavirus	coronavirus	NN
10_1101-2020_09_09_289074	20	67	2	2	CD
10_1101-2020_09_09_289074	20	68	Main	Main	NNP
10_1101-2020_09_09_289074	20	69	Text	Text	NNP
10_1101-2020_09_09_289074	20	70	Introduction	introduction	NN
10_1101-2020_09_09_289074	20	71	The	the	DT
10_1101-2020_09_09_289074	20	72	Severe	Severe	NNP
10_1101-2020_09_09_289074	20	73	Acute	Acute	NNP
10_1101-2020_09_09_289074	20	74	Respiratory	respiratory	JJ
10_1101-2020_09_09_289074	20	75	Syndrome	Syndrome	NNP
10_1101-2020_09_09_289074	20	76	Coronavirus	Coronavirus	NNP
10_1101-2020_09_09_289074	20	77	2	2	CD
10_1101-2020_09_09_289074	20	78	(	(	-LRB-
10_1101-2020_09_09_289074	20	79	SARS	SARS	NNP
10_1101-2020_09_09_289074	20	80	-	-	HYPH
10_1101-2020_09_09_289074	20	81	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	20	82	)	)	-RRB-
10_1101-2020_09_09_289074	20	83	has	have	VBZ
10_1101-2020_09_09_289074	20	84	emerged	emerge	VBN
10_1101-2020_09_09_289074	20	85	in	in	IN
10_1101-2020_09_09_289074	20	86	late	late	JJ
10_1101-2020_09_09_289074	20	87	2019	2019	CD
10_1101-2020_09_09_289074	20	88	(	(	-LRB-
10_1101-2020_09_09_289074	20	89	1	1	CD
10_1101-2020_09_09_289074	20	90	)	)	-RRB-
10_1101-2020_09_09_289074	20	91	as	as	IN
10_1101-2020_09_09_289074	20	92	the	the	DT
10_1101-2020_09_09_289074	20	93	etiological	etiological	JJ
10_1101-2020_09_09_289074	20	94	cause	cause	NN
10_1101-2020_09_09_289074	20	95	of	of	IN
10_1101-2020_09_09_289074	20	96	a	a	DT
10_1101-2020_09_09_289074	20	97	pandemic	pandemic	NN
10_1101-2020_09_09_289074	20	98	of	of	IN
10_1101-2020_09_09_289074	20	99	severe	severe	JJ
10_1101-2020_09_09_289074	20	100	proportions	proportion	NNS
10_1101-2020_09_09_289074	20	101	dubbed	dub	VBD
10_1101-2020_09_09_289074	20	102	Coronavirus	Coronavirus	NNP
10_1101-2020_09_09_289074	20	103	Disease	Disease	NNP
10_1101-2020_09_09_289074	20	104	19	19	CD
10_1101-2020_09_09_289074	20	105	(	(	-LRB-
10_1101-2020_09_09_289074	20	106	COVID-	COVID-	NNP
10_1101-2020_09_09_289074	20	107	19	19	CD
10_1101-2020_09_09_289074	20	108	)	)	-RRB-
10_1101-2020_09_09_289074	20	109	.	.	.
10_1101-2020_09_09_289074	21	1	The	the	DT
10_1101-2020_09_09_289074	21	2	disease	disease	NN
10_1101-2020_09_09_289074	21	3	has	have	VBZ
10_1101-2020_09_09_289074	21	4	reached	reach	VBN
10_1101-2020_09_09_289074	21	5	virtually	virtually	RB
10_1101-2020_09_09_289074	21	6	every	every	DT
10_1101-2020_09_09_289074	21	7	country	country	NN
10_1101-2020_09_09_289074	21	8	in	in	IN
10_1101-2020_09_09_289074	21	9	the	the	DT
10_1101-2020_09_09_289074	21	10	globe	globe	NN
10_1101-2020_09_09_289074	21	11	(	(	-LRB-
10_1101-2020_09_09_289074	21	12	2	2	CD
10_1101-2020_09_09_289074	21	13	)	)	-RRB-
10_1101-2020_09_09_289074	21	14	,	,	,
10_1101-2020_09_09_289074	21	15	with	with	IN
10_1101-2020_09_09_289074	21	16	more	more	JJR
10_1101-2020_09_09_289074	21	17	than	than	IN
10_1101-2020_09_09_289074	21	18	40,000,000	40,000,000	CD
10_1101-2020_09_09_289074	21	19	.CC	.CC	:
10_1101-2020_09_09_289074	21	20	-	-	:
10_1101-2020_09_09_289074	21	21	BY	by	IN
10_1101-2020_09_09_289074	21	22	-	-	HYPH
10_1101-2020_09_09_289074	21	23	NC	NC	NNP
10_1101-2020_09_09_289074	21	24	-	-	HYPH
10_1101-2020_09_09_289074	21	25	ND	ND	NNP
10_1101-2020_09_09_289074	21	26	4.0	4.0	CD
10_1101-2020_09_09_289074	21	27	International	International	NNP
10_1101-2020_09_09_289074	21	28	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	21	29	under	under	IN
10_1101-2020_09_09_289074	21	30	a	a	DT
10_1101-2020_09_09_289074	21	31	(	(	-LRB-
10_1101-2020_09_09_289074	21	32	which	which	WDT
10_1101-2020_09_09_289074	21	33	was	be	VBD
10_1101-2020_09_09_289074	21	34	not	not	RB
10_1101-2020_09_09_289074	21	35	certified	certify	VBN
10_1101-2020_09_09_289074	21	36	by	by	IN
10_1101-2020_09_09_289074	21	37	peer	peer	NN
10_1101-2020_09_09_289074	21	38	review	review	NN
10_1101-2020_09_09_289074	21	39	)	)	-RRB-
10_1101-2020_09_09_289074	21	40	is	be	VBZ
10_1101-2020_09_09_289074	21	41	the	the	DT
10_1101-2020_09_09_289074	21	42	author	author	NN
10_1101-2020_09_09_289074	21	43	/	/	SYM
10_1101-2020_09_09_289074	21	44	funder	funder	NN
10_1101-2020_09_09_289074	21	45	,	,	,
10_1101-2020_09_09_289074	21	46	who	who	WP
10_1101-2020_09_09_289074	21	47	has	have	VBZ
10_1101-2020_09_09_289074	21	48	granted	grant	VBN
10_1101-2020_09_09_289074	21	49	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	21	50	a	a	DT
10_1101-2020_09_09_289074	21	51	license	license	NN
10_1101-2020_09_09_289074	21	52	to	to	TO
10_1101-2020_09_09_289074	21	53	display	display	VB
10_1101-2020_09_09_289074	21	54	the	the	DT
10_1101-2020_09_09_289074	21	55	preprint	preprint	NN
10_1101-2020_09_09_289074	21	56	in	in	IN
10_1101-2020_09_09_289074	21	57	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	21	58	.	.	.
10_1101-2020_09_09_289074	22	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	22	2	is	be	VBZ
10_1101-2020_09_09_289074	22	3	made	make	VBN
10_1101-2020_09_09_289074	22	4	The	the	DT
10_1101-2020_09_09_289074	22	5	copyright	copyright	NN
10_1101-2020_09_09_289074	22	6	holder	holder	NN
10_1101-2020_09_09_289074	22	7	for	for	IN
10_1101-2020_09_09_289074	22	8	this	this	DT
10_1101-2020_09_09_289074	22	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	22	10	version	version	NN
10_1101-2020_09_09_289074	22	11	posted	post	VBD
10_1101-2020_09_09_289074	22	12	January	January	NNP
10_1101-2020_09_09_289074	22	13	5	5	CD
10_1101-2020_09_09_289074	22	14	,	,	,
10_1101-2020_09_09_289074	22	15	2021	2021	CD
10_1101-2020_09_09_289074	22	16	.	.	.
10_1101-2020_09_09_289074	22	17	;	;	:
10_1101-2020_09_09_289074	22	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	22	19	:	:	:
10_1101-2020_09_09_289074	22	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	22	21	preprint	preprint	NN
10_1101-2020_09_09_289074	22	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	22	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NNP
10_1101-2020_09_09_289074	22	24	3	3	CD
10_1101-2020_09_09_289074	22	25	confirmed	confirm	VBD
10_1101-2020_09_09_289074	22	26	cases	case	NNS
10_1101-2020_09_09_289074	22	27	and	and	CC
10_1101-2020_09_09_289074	22	28	more	more	JJR
10_1101-2020_09_09_289074	22	29	than	than	IN
10_1101-2020_09_09_289074	22	30	1,100,000	1,100,000	CD
10_1101-2020_09_09_289074	22	31	deaths	death	NNS
10_1101-2020_09_09_289074	22	32	(	(	-LRB-
10_1101-2020_09_09_289074	22	33	source	source	NN
10_1101-2020_09_09_289074	22	34	:	:	:
10_1101-2020_09_09_289074	22	35	World	World	NNP
10_1101-2020_09_09_289074	22	36	Health	Health	NNP
10_1101-2020_09_09_289074	22	37	Organization	Organization	NNP
10_1101-2020_09_09_289074	22	38	)	)	-RRB-
10_1101-2020_09_09_289074	22	39	.	.	.
10_1101-2020_09_09_289074	23	1	SARS	SARS	NNP
10_1101-2020_09_09_289074	23	2	-	-	HYPH
10_1101-2020_09_09_289074	23	3	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	23	4	is	be	VBZ
10_1101-2020_09_09_289074	23	5	characterized	characterize	VBN
10_1101-2020_09_09_289074	23	6	by	by	IN
10_1101-2020_09_09_289074	23	7	a	a	DT
10_1101-2020_09_09_289074	23	8	29,903-long	29,903-long	CD
10_1101-2020_09_09_289074	23	9	single	single	JJ
10_1101-2020_09_09_289074	23	10	stranded	strand	VBN
10_1101-2020_09_09_289074	23	11	RNA	RNA	NNP
10_1101-2020_09_09_289074	23	12	genome	genome	NN
10_1101-2020_09_09_289074	23	13	,	,	,
10_1101-2020_09_09_289074	23	14	densely	densely	RB
10_1101-2020_09_09_289074	23	15	packed	pack	VBN
10_1101-2020_09_09_289074	23	16	in	in	IN
10_1101-2020_09_09_289074	23	17	11	11	CD
10_1101-2020_09_09_289074	23	18	Open	open	JJ
10_1101-2020_09_09_289074	23	19	Reading	reading	NN
10_1101-2020_09_09_289074	23	20	Frames	frame	NNS
10_1101-2020_09_09_289074	23	21	(	(	-LRB-
10_1101-2020_09_09_289074	23	22	ORFs	ORFs	NNPS
10_1101-2020_09_09_289074	23	23	)	)	-RRB-
10_1101-2020_09_09_289074	23	24	;	;	:
10_1101-2020_09_09_289074	23	25	the	the	DT
10_1101-2020_09_09_289074	23	26	ORF1	ORF1	NNP
10_1101-2020_09_09_289074	23	27	encodes	encode	VBZ
10_1101-2020_09_09_289074	23	28	for	for	IN
10_1101-2020_09_09_289074	23	29	a	a	DT
10_1101-2020_09_09_289074	23	30	polyprotein	polyprotein	NN
10_1101-2020_09_09_289074	23	31	which	which	WDT
10_1101-2020_09_09_289074	23	32	is	be	VBZ
10_1101-2020_09_09_289074	23	33	furtherly	furtherly	RB
10_1101-2020_09_09_289074	23	34	split	split	VBN
10_1101-2020_09_09_289074	23	35	in	in	IN
10_1101-2020_09_09_289074	23	36	16	16	CD
10_1101-2020_09_09_289074	23	37	proteins	protein	NNS
10_1101-2020_09_09_289074	23	38	,	,	,
10_1101-2020_09_09_289074	23	39	for	for	IN
10_1101-2020_09_09_289074	23	40	a	a	DT
10_1101-2020_09_09_289074	23	41	total	total	NN
10_1101-2020_09_09_289074	23	42	of	of	IN
10_1101-2020_09_09_289074	23	43	26	26	CD
10_1101-2020_09_09_289074	23	44	proteins	protein	NNS
10_1101-2020_09_09_289074	23	45	(	(	-LRB-
10_1101-2020_09_09_289074	23	46	3	3	CD
10_1101-2020_09_09_289074	23	47	)	)	-RRB-
10_1101-2020_09_09_289074	23	48	.	.	.
10_1101-2020_09_09_289074	24	1	The	the	DT
10_1101-2020_09_09_289074	24	2	second	second	JJ
10_1101-2020_09_09_289074	24	3	ORF	ORF	NNP
10_1101-2020_09_09_289074	24	4	encodes	encode	NNS
10_1101-2020_09_09_289074	24	5	for	for	IN
10_1101-2020_09_09_289074	24	6	the	the	DT
10_1101-2020_09_09_289074	24	7	Spike	Spike	NNP
10_1101-2020_09_09_289074	24	8	(	(	-LRB-
10_1101-2020_09_09_289074	24	9	S	S	NNP
10_1101-2020_09_09_289074	24	10	)	)	-RRB-
10_1101-2020_09_09_289074	24	11	protein	protein	NN
10_1101-2020_09_09_289074	24	12	,	,	,
10_1101-2020_09_09_289074	24	13	which	which	WDT
10_1101-2020_09_09_289074	24	14	is	be	VBZ
10_1101-2020_09_09_289074	24	15	the	the	DT
10_1101-2020_09_09_289074	24	16	key	key	JJ
10_1101-2020_09_09_289074	24	17	protagonist	protagonist	NN
10_1101-2020_09_09_289074	24	18	in	in	IN
10_1101-2020_09_09_289074	24	19	the	the	DT
10_1101-2020_09_09_289074	24	20	viral	viral	JJ
10_1101-2020_09_09_289074	24	21	entry	entry	NN
10_1101-2020_09_09_289074	24	22	into	into	IN
10_1101-2020_09_09_289074	24	23	host	host	NN
10_1101-2020_09_09_289074	24	24	cells	cell	NNS
10_1101-2020_09_09_289074	24	25	,	,	,
10_1101-2020_09_09_289074	24	26	through	through	IN
10_1101-2020_09_09_289074	24	27	its	-PRON-	PRP$
10_1101-2020_09_09_289074	24	28	interaction	interaction	NN
10_1101-2020_09_09_289074	24	29	with	with	IN
10_1101-2020_09_09_289074	24	30	human	human	JJ
10_1101-2020_09_09_289074	24	31	epithelial	epithelial	JJ
10_1101-2020_09_09_289074	24	32	cell	cell	NN
10_1101-2020_09_09_289074	24	33	receptors	receptor	NNS
10_1101-2020_09_09_289074	24	34	Angiotensin	Angiotensin	NNP
10_1101-2020_09_09_289074	24	35	Converting	Converting	NNP
10_1101-2020_09_09_289074	24	36	Enzyme	Enzyme	NNPS
10_1101-2020_09_09_289074	24	37	2	2	CD
10_1101-2020_09_09_289074	24	38	(	(	-LRB-
10_1101-2020_09_09_289074	24	39	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	24	40	)	)	-RRB-
10_1101-2020_09_09_289074	24	41	(	(	-LRB-
10_1101-2020_09_09_289074	24	42	4	4	CD
10_1101-2020_09_09_289074	24	43	)	)	-RRB-
10_1101-2020_09_09_289074	24	44	,	,	,
10_1101-2020_09_09_289074	24	45	Transmembrane	Transmembrane	NNP
10_1101-2020_09_09_289074	24	46	Serine	Serine	NNP
10_1101-2020_09_09_289074	24	47	Protease	Protease	NNP
10_1101-2020_09_09_289074	24	48	2	2	CD
10_1101-2020_09_09_289074	24	49	(	(	-LRB-
10_1101-2020_09_09_289074	24	50	TMPRSS2	TMPRSS2	NNP
10_1101-2020_09_09_289074	24	51	)	)	-RRB-
10_1101-2020_09_09_289074	24	52	(	(	-LRB-
10_1101-2020_09_09_289074	24	53	5	5	CD
10_1101-2020_09_09_289074	24	54	)	)	-RRB-
10_1101-2020_09_09_289074	24	55	,	,	,
10_1101-2020_09_09_289074	24	56	Furin	Furin	NNP
10_1101-2020_09_09_289074	24	57	(	(	-LRB-
10_1101-2020_09_09_289074	24	58	6	6	CD
10_1101-2020_09_09_289074	24	59	)	)	-RRB-
10_1101-2020_09_09_289074	24	60	and	and	CC
10_1101-2020_09_09_289074	24	61	CD147	CD147	NNP
10_1101-2020_09_09_289074	24	62	(	(	-LRB-
10_1101-2020_09_09_289074	24	63	7	7	CD
10_1101-2020_09_09_289074	24	64	)	)	-RRB-
10_1101-2020_09_09_289074	24	65	.	.	.
10_1101-2020_09_09_289074	25	1	Investigators	investigator	NNS
10_1101-2020_09_09_289074	25	2	have	have	VBP
10_1101-2020_09_09_289074	25	3	focused	focus	VBN
10_1101-2020_09_09_289074	25	4	their	-PRON-	PRP$
10_1101-2020_09_09_289074	25	5	attention	attention	NN
10_1101-2020_09_09_289074	25	6	on	on	IN
10_1101-2020_09_09_289074	25	7	the	the	DT
10_1101-2020_09_09_289074	25	8	Spike	Spike	NNP
10_1101-2020_09_09_289074	25	9	/	/	SYM
10_1101-2020_09_09_289074	25	10	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	25	11	interaction	interaction	NN
10_1101-2020_09_09_289074	25	12	,	,	,
10_1101-2020_09_09_289074	25	13	trying	try	VBG
10_1101-2020_09_09_289074	25	14	to	to	TO
10_1101-2020_09_09_289074	25	15	disrupt	disrupt	VB
10_1101-2020_09_09_289074	25	16	it	-PRON-	PRP
10_1101-2020_09_09_289074	25	17	as	as	IN
10_1101-2020_09_09_289074	25	18	a	a	DT
10_1101-2020_09_09_289074	25	19	potential	potential	JJ
10_1101-2020_09_09_289074	25	20	anti	anti	JJ
10_1101-2020_09_09_289074	25	21	-	-	JJ
10_1101-2020_09_09_289074	25	22	COVID-19	covid-19	JJ
10_1101-2020_09_09_289074	25	23	therapy	therapy	NN
10_1101-2020_09_09_289074	25	24	,	,	,
10_1101-2020_09_09_289074	25	25	using	use	VBG
10_1101-2020_09_09_289074	25	26	small	small	JJ
10_1101-2020_09_09_289074	25	27	drugs	drug	NNS
10_1101-2020_09_09_289074	25	28	(	(	-LRB-
10_1101-2020_09_09_289074	25	29	8)	8)	CD
10_1101-2020_09_09_289074	25	30	or	or	CC
10_1101-2020_09_09_289074	25	31	Spike	Spike	NNP
10_1101-2020_09_09_289074	25	32	fragments	fragment	NNS
10_1101-2020_09_09_289074	25	33	(	(	-LRB-
10_1101-2020_09_09_289074	25	34	9	9	CD
10_1101-2020_09_09_289074	25	35	)	)	-RRB-
10_1101-2020_09_09_289074	25	36	.	.	.
10_1101-2020_09_09_289074	26	1	Using	use	VBG
10_1101-2020_09_09_289074	26	2	X	x	NN
10_1101-2020_09_09_289074	26	3	-	-	NN
10_1101-2020_09_09_289074	26	4	ray	ray	NN
10_1101-2020_09_09_289074	26	5	crystallography	crystallography	NN
10_1101-2020_09_09_289074	26	6	,	,	,
10_1101-2020_09_09_289074	26	7	some	some	DT
10_1101-2020_09_09_289074	26	8	models	model	NNS
10_1101-2020_09_09_289074	26	9	of	of	IN
10_1101-2020_09_09_289074	26	10	the	the	DT
10_1101-2020_09_09_289074	26	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	26	12	/	/	SYM
10_1101-2020_09_09_289074	26	13	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	26	14	have	have	VBP
10_1101-2020_09_09_289074	26	15	been	be	VBN
10_1101-2020_09_09_289074	26	16	generated	generate	VBN
10_1101-2020_09_09_289074	26	17	(	(	-LRB-
10_1101-2020_09_09_289074	26	18	10–12	10–12	CD
10_1101-2020_09_09_289074	26	19	)	)	-RRB-
10_1101-2020_09_09_289074	26	20	,	,	,
10_1101-2020_09_09_289074	26	21	providing	provide	VBG
10_1101-2020_09_09_289074	26	22	a	a	DT
10_1101-2020_09_09_289074	26	23	structural	structural	JJ
10_1101-2020_09_09_289074	26	24	instrument	instrument	NN
10_1101-2020_09_09_289074	26	25	for	for	IN
10_1101-2020_09_09_289074	26	26	the	the	DT
10_1101-2020_09_09_289074	26	27	analysis	analysis	NN
10_1101-2020_09_09_289074	26	28	of	of	IN
10_1101-2020_09_09_289074	26	29	this	this	DT
10_1101-2020_09_09_289074	26	30	key	key	JJ
10_1101-2020_09_09_289074	26	31	interaction	interaction	NN
10_1101-2020_09_09_289074	26	32	.	.	.
10_1101-2020_09_09_289074	27	1	These	these	DT
10_1101-2020_09_09_289074	27	2	models	model	NNS
10_1101-2020_09_09_289074	27	3	determined	determine	VBD
10_1101-2020_09_09_289074	27	4	that	that	IN
10_1101-2020_09_09_289074	27	5	the	the	DT
10_1101-2020_09_09_289074	27	6	Receptor	Receptor	NNP
10_1101-2020_09_09_289074	27	7	Binding	Binding	NNP
10_1101-2020_09_09_289074	27	8	Domain	Domain	NNP
10_1101-2020_09_09_289074	27	9	(	(	-LRB-
10_1101-2020_09_09_289074	27	10	RBD	RBD	NNP
10_1101-2020_09_09_289074	27	11	)	)	-RRB-
10_1101-2020_09_09_289074	27	12	of	of	IN
10_1101-2020_09_09_289074	27	13	Spike	Spike	NNP
10_1101-2020_09_09_289074	27	14	,	,	,
10_1101-2020_09_09_289074	27	15	directly	directly	RB
10_1101-2020_09_09_289074	27	16	interacting	interact	VBG
10_1101-2020_09_09_289074	27	17	with	with	IN
10_1101-2020_09_09_289074	27	18	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	27	19	,	,	,
10_1101-2020_09_09_289074	27	20	is	be	VBZ
10_1101-2020_09_09_289074	27	21	a	a	DT
10_1101-2020_09_09_289074	27	22	compact	compact	JJ
10_1101-2020_09_09_289074	27	23	structure	structure	NN
10_1101-2020_09_09_289074	27	24	of	of	IN
10_1101-2020_09_09_289074	27	25	~200	~200	JJ
10_1101-2020_09_09_289074	27	26	amino	amino	JJ
10_1101-2020_09_09_289074	27	27	acids	acid	NNS
10_1101-2020_09_09_289074	27	28	(	(	-LRB-
10_1101-2020_09_09_289074	27	29	AAs	aas	NN
10_1101-2020_09_09_289074	27	30	)	)	-RRB-
10_1101-2020_09_09_289074	27	31	over	over	IN
10_1101-2020_09_09_289074	27	32	a	a	DT
10_1101-2020_09_09_289074	27	33	total	total	NN
10_1101-2020_09_09_289074	27	34	of	of	IN
10_1101-2020_09_09_289074	27	35	1273	1273	CD
10_1101-2020_09_09_289074	27	36	AAs	aa	NNS
10_1101-2020_09_09_289074	27	37	of	of	IN
10_1101-2020_09_09_289074	27	38	the	the	DT
10_1101-2020_09_09_289074	27	39	full	full	JJ
10_1101-2020_09_09_289074	27	40	-	-	HYPH
10_1101-2020_09_09_289074	27	41	length	length	NN
10_1101-2020_09_09_289074	27	42	Spike	Spike	NNP
10_1101-2020_09_09_289074	27	43	.	.	.
10_1101-2020_09_09_289074	28	1	The	the	DT
10_1101-2020_09_09_289074	28	2	SARS	SARS	NNP
10_1101-2020_09_09_289074	28	3	-	-	HYPH
10_1101-2020_09_09_289074	28	4	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	28	5	Spike	Spike	NNP
10_1101-2020_09_09_289074	28	6	protein	protein	NN
10_1101-2020_09_09_289074	28	7	adapted	adapt	VBD
10_1101-2020_09_09_289074	28	8	from	from	IN
10_1101-2020_09_09_289074	28	9	subsequent	subsequent	JJ
10_1101-2020_09_09_289074	28	10	mutations	mutation	NNS
10_1101-2020_09_09_289074	28	11	from	from	IN
10_1101-2020_09_09_289074	28	12	a	a	DT
10_1101-2020_09_09_289074	28	13	wild	wild	JJ
10_1101-2020_09_09_289074	28	14	bat	bat	NN
10_1101-2020_09_09_289074	28	15	beta	beta	NN
10_1101-2020_09_09_289074	28	16	-	-	HYPH
10_1101-2020_09_09_289074	28	17	coronavirus	coronavirus	NN
10_1101-2020_09_09_289074	28	18	(	(	-LRB-
10_1101-2020_09_09_289074	28	19	13	13	CD
10_1101-2020_09_09_289074	28	20	)	)	-RRB-
10_1101-2020_09_09_289074	28	21	,	,	,
10_1101-2020_09_09_289074	28	22	in	in	IN
10_1101-2020_09_09_289074	28	23	order	order	NN
10_1101-2020_09_09_289074	28	24	to	to	TO
10_1101-2020_09_09_289074	28	25	exploit	exploit	VB
10_1101-2020_09_09_289074	28	26	the	the	DT
10_1101-2020_09_09_289074	28	27	N	n	NN
10_1101-2020_09_09_289074	28	28	-	-	HYPH
10_1101-2020_09_09_289074	28	29	terminal	terminal	NN
10_1101-2020_09_09_289074	28	30	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	28	31	peptidase	peptidase	NN
10_1101-2020_09_09_289074	28	32	domain	domain	NN
10_1101-2020_09_09_289074	28	33	conformation	conformation	NN
10_1101-2020_09_09_289074	28	34	.	.	.
10_1101-2020_09_09_289074	29	1	As	as	IN
10_1101-2020_09_09_289074	29	2	a	a	DT
10_1101-2020_09_09_289074	29	3	result	result	NN
10_1101-2020_09_09_289074	29	4	,	,	,
10_1101-2020_09_09_289074	29	5	SARS	SARS	NNP
10_1101-2020_09_09_289074	29	6	-	-	HYPH
10_1101-2020_09_09_289074	29	7	CoV-	CoV-	NNP
10_1101-2020_09_09_289074	29	8	2	2	CD
10_1101-2020_09_09_289074	29	9	Spike	Spike	NNP
10_1101-2020_09_09_289074	29	10	can	can	MD
10_1101-2020_09_09_289074	29	11	establish	establish	VB
10_1101-2020_09_09_289074	29	12	a	a	DT
10_1101-2020_09_09_289074	29	13	strong	strong	JJ
10_1101-2020_09_09_289074	29	14	interaction	interaction	NN
10_1101-2020_09_09_289074	29	15	with	with	IN
10_1101-2020_09_09_289074	29	16	the	the	DT
10_1101-2020_09_09_289074	29	17	human	human	JJ
10_1101-2020_09_09_289074	29	18	cell	cell	NN
10_1101-2020_09_09_289074	29	19	surface	surface	NN
10_1101-2020_09_09_289074	29	20	,	,	,
10_1101-2020_09_09_289074	29	21	allowing	allow	VBG
10_1101-2020_09_09_289074	29	22	the	the	DT
10_1101-2020_09_09_289074	29	23	virus	virus	NN
10_1101-2020_09_09_289074	29	24	to	to	TO
10_1101-2020_09_09_289074	29	25	fuse	fuse	VB
10_1101-2020_09_09_289074	29	26	its	-PRON-	PRP$
10_1101-2020_09_09_289074	29	27	membrane	membrane	NN
10_1101-2020_09_09_289074	29	28	with	with	IN
10_1101-2020_09_09_289074	29	29	that	that	DT
10_1101-2020_09_09_289074	29	30	of	of	IN
10_1101-2020_09_09_289074	29	31	the	the	DT
10_1101-2020_09_09_289074	29	32	host	host	NN
10_1101-2020_09_09_289074	29	33	cell	cell	NN
10_1101-2020_09_09_289074	29	34	,	,	,
10_1101-2020_09_09_289074	29	35	releasing	release	VBG
10_1101-2020_09_09_289074	29	36	its	-PRON-	PRP$
10_1101-2020_09_09_289074	29	37	proteins	protein	NNS
10_1101-2020_09_09_289074	29	38	and	and	CC
10_1101-2020_09_09_289074	29	39	genetic	genetic	JJ
10_1101-2020_09_09_289074	29	40	material	material	NN
10_1101-2020_09_09_289074	29	41	and	and	CC
10_1101-2020_09_09_289074	29	42	starting	start	VBG
10_1101-2020_09_09_289074	29	43	its	-PRON-	PRP$
10_1101-2020_09_09_289074	29	44	replication	replication	NN
10_1101-2020_09_09_289074	29	45	cycle	cycle	NN
10_1101-2020_09_09_289074	29	46	(	(	-LRB-
10_1101-2020_09_09_289074	29	47	5	5	CD
10_1101-2020_09_09_289074	29	48	)	)	-RRB-
10_1101-2020_09_09_289074	29	49	.	.	.
10_1101-2020_09_09_289074	30	1	While	while	IN
10_1101-2020_09_09_289074	30	2	SARS	SARS	NNP
10_1101-2020_09_09_289074	30	3	-	-	HYPH
10_1101-2020_09_09_289074	30	4	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	30	5	shows	show	VBZ
10_1101-2020_09_09_289074	30	6	low	low	JJ
10_1101-2020_09_09_289074	30	7	mutability	mutability	NN
10_1101-2020_09_09_289074	30	8	(	(	-LRB-
10_1101-2020_09_09_289074	30	9	14	14	CD
10_1101-2020_09_09_289074	30	10	)	)	-RRB-
10_1101-2020_09_09_289074	30	11	,	,	,
10_1101-2020_09_09_289074	30	12	with	with	IN
10_1101-2020_09_09_289074	30	13	less	less	JJR
10_1101-2020_09_09_289074	30	14	than	than	IN
10_1101-2020_09_09_289074	30	15	25	25	CD
10_1101-2020_09_09_289074	30	16	predicted	predict	VBN
10_1101-2020_09_09_289074	30	17	events	event	NNS
10_1101-2020_09_09_289074	30	18	/	/	SYM
10_1101-2020_09_09_289074	30	19	year	year	NN
10_1101-2020_09_09_289074	30	20	(	(	-LRB-
10_1101-2020_09_09_289074	30	21	15	15	CD
10_1101-2020_09_09_289074	30	22	)	)	-RRB-
10_1101-2020_09_09_289074	30	23	,	,	,
10_1101-2020_09_09_289074	30	24	the	the	DT
10_1101-2020_09_09_289074	30	25	virus	virus	NN
10_1101-2020_09_09_289074	30	26	is	be	VBZ
10_1101-2020_09_09_289074	30	27	in	in	IN
10_1101-2020_09_09_289074	30	28	continuous	continuous	JJ
10_1101-2020_09_09_289074	30	29	evolution	evolution	NN
10_1101-2020_09_09_289074	30	30	from	from	IN
10_1101-2020_09_09_289074	30	31	the	the	DT
10_1101-2020_09_09_289074	30	32	original	original	JJ
10_1101-2020_09_09_289074	30	33	Wuhan	Wuhan	NNP
10_1101-2020_09_09_289074	30	34	reference	reference	NN
10_1101-2020_09_09_289074	30	35	sequence	sequence	NN
10_1101-2020_09_09_289074	30	36	(	(	-LRB-
10_1101-2020_09_09_289074	30	37	NC_045512.2	NC_045512.2	NNP
10_1101-2020_09_09_289074	30	38	)	)	-RRB-
10_1101-2020_09_09_289074	30	39	(	(	-LRB-
10_1101-2020_09_09_289074	30	40	16	16	CD
10_1101-2020_09_09_289074	30	41	)	)	-RRB-
10_1101-2020_09_09_289074	30	42	,	,	,
10_1101-2020_09_09_289074	30	43	and	and	CC
10_1101-2020_09_09_289074	30	44	there	there	EX
10_1101-2020_09_09_289074	30	45	are	be	VBP
10_1101-2020_09_09_289074	30	46	currently	currently	RB
10_1101-2020_09_09_289074	30	47	at	at	IN
10_1101-2020_09_09_289074	30	48	least	least	RBS
10_1101-2020_09_09_289074	30	49	6	6	CD
10_1101-2020_09_09_289074	30	50	major	major	JJ
10_1101-2020_09_09_289074	30	51	variants	variant	NNS
10_1101-2020_09_09_289074	30	52	circulating	circulate	VBG
10_1101-2020_09_09_289074	30	53	in	in	IN
10_1101-2020_09_09_289074	30	54	the	the	DT
10_1101-2020_09_09_289074	30	55	population	population	NN
10_1101-2020_09_09_289074	30	56	(	(	-LRB-
10_1101-2020_09_09_289074	30	57	3	3	CD
10_1101-2020_09_09_289074	30	58	,	,	,
10_1101-2020_09_09_289074	30	59	17	17	CD
10_1101-2020_09_09_289074	30	60	)	)	-RRB-
10_1101-2020_09_09_289074	30	61	.	.	.
10_1101-2020_09_09_289074	31	1	Some	some	DT
10_1101-2020_09_09_289074	31	2	of	of	IN
10_1101-2020_09_09_289074	31	3	these	these	DT
10_1101-2020_09_09_289074	31	4	strains	strain	NNS
10_1101-2020_09_09_289074	31	5	are	be	VBP
10_1101-2020_09_09_289074	31	6	characterized	characterize	VBN
10_1101-2020_09_09_289074	31	7	by	by	IN
10_1101-2020_09_09_289074	31	8	a	a	DT
10_1101-2020_09_09_289074	31	9	mutation	mutation	NN
10_1101-2020_09_09_289074	31	10	in	in	IN
10_1101-2020_09_09_289074	31	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	31	12	,	,	,
10_1101-2020_09_09_289074	31	13	at	at	IN
10_1101-2020_09_09_289074	31	14	AA	AA	NNP
10_1101-2020_09_09_289074	31	15	614	614	CD
10_1101-2020_09_09_289074	31	16	,	,	,
10_1101-2020_09_09_289074	31	17	whereas	whereas	IN
10_1101-2020_09_09_289074	31	18	an	an	DT
10_1101-2020_09_09_289074	31	19	Aspartic	aspartic	JJ
10_1101-2020_09_09_289074	31	20	Acid	Acid	NNP
10_1101-2020_09_09_289074	31	21	(	(	-LRB-
10_1101-2020_09_09_289074	31	22	D	d	NN
10_1101-2020_09_09_289074	31	23	)	)	-RRB-
10_1101-2020_09_09_289074	31	24	is	be	VBZ
10_1101-2020_09_09_289074	31	25	substituted	substitute	VBN
10_1101-2020_09_09_289074	31	26	by	by	IN
10_1101-2020_09_09_289074	31	27	a	a	DT
10_1101-2020_09_09_289074	31	28	Glycine	Glycine	NNP
10_1101-2020_09_09_289074	31	29	(	(	-LRB-
10_1101-2020_09_09_289074	31	30	G	G	NNP
10_1101-2020_09_09_289074	31	31	)	)	-RRB-
10_1101-2020_09_09_289074	31	32	(	(	-LRB-
10_1101-2020_09_09_289074	31	33	18	18	CD
10_1101-2020_09_09_289074	31	34	)	)	-RRB-
10_1101-2020_09_09_289074	31	35	.	.	.
10_1101-2020_09_09_289074	32	1	In	in	IN
10_1101-2020_09_09_289074	32	2	fact	fact	NN
10_1101-2020_09_09_289074	32	3	,	,	,
10_1101-2020_09_09_289074	32	4	the	the	DT
10_1101-2020_09_09_289074	32	5	Spike	Spike	NNP
10_1101-2020_09_09_289074	32	6	D614	D614	NNP
10_1101-2020_09_09_289074	32	7	G	G	NNP
10_1101-2020_09_09_289074	32	8	mutation	mutation	NN
10_1101-2020_09_09_289074	32	9	gives	give	VBZ
10_1101-2020_09_09_289074	32	10	the	the	DT
10_1101-2020_09_09_289074	32	11	name	name	NN
10_1101-2020_09_09_289074	32	12	to	to	IN
10_1101-2020_09_09_289074	32	13	the	the	DT
10_1101-2020_09_09_289074	32	14	most	most	RBS
10_1101-2020_09_09_289074	32	15	frequent	frequent	JJ
10_1101-2020_09_09_289074	32	16	viral	viral	JJ
10_1101-2020_09_09_289074	32	17	clade	clade	NN
10_1101-2020_09_09_289074	32	18	(	(	-LRB-
10_1101-2020_09_09_289074	32	19	G	G	NNP
10_1101-2020_09_09_289074	32	20	)	)	-RRB-
10_1101-2020_09_09_289074	32	21	,	,	,
10_1101-2020_09_09_289074	32	22	which	which	WDT
10_1101-2020_09_09_289074	32	23	was	be	VBD
10_1101-2020_09_09_289074	32	24	first	first	RB
10_1101-2020_09_09_289074	32	25	detected	detect	VBN
10_1101-2020_09_09_289074	32	26	in	in	IN
10_1101-2020_09_09_289074	32	27	Europe	Europe	NNP
10_1101-2020_09_09_289074	32	28	at	at	IN
10_1101-2020_09_09_289074	32	29	the	the	DT
10_1101-2020_09_09_289074	32	30	end	end	NN
10_1101-2020_09_09_289074	32	31	of	of	IN
10_1101-2020_09_09_289074	32	32	January	January	NNP
10_1101-2020_09_09_289074	32	33	2020	2020	CD
10_1101-2020_09_09_289074	32	34	,	,	,
10_1101-2020_09_09_289074	32	35	and	and	CC
10_1101-2020_09_09_289074	32	36	is	be	VBZ
10_1101-2020_09_09_289074	32	37	currently	currently	RB
10_1101-2020_09_09_289074	32	38	present	present	JJ
10_1101-2020_09_09_289074	32	39	in	in	IN
10_1101-2020_09_09_289074	32	40	all	all	DT
10_1101-2020_09_09_289074	32	41	continents	continent	NNS
10_1101-2020_09_09_289074	32	42	,	,	,
10_1101-2020_09_09_289074	32	43	with	with	IN
10_1101-2020_09_09_289074	32	44	increasing	increase	VBG
10_1101-2020_09_09_289074	32	45	frequency	frequency	NN
10_1101-2020_09_09_289074	32	46	over	over	IN
10_1101-2020_09_09_289074	32	47	time	time	NN
10_1101-2020_09_09_289074	32	48	(	(	-LRB-
10_1101-2020_09_09_289074	32	49	3	3	CD
10_1101-2020_09_09_289074	32	50	)	)	-RRB-
10_1101-2020_09_09_289074	32	51	.	.	.
10_1101-2020_09_09_289074	33	1	D614	D614	NNP
10_1101-2020_09_09_289074	33	2	G	g	NN
10_1101-2020_09_09_289074	33	3	does	do	VBZ
10_1101-2020_09_09_289074	33	4	not	not	RB
10_1101-2020_09_09_289074	33	5	fall	fall	VB
10_1101-2020_09_09_289074	33	6	within	within	IN
10_1101-2020_09_09_289074	33	7	the	the	DT
10_1101-2020_09_09_289074	33	8	putative	putative	JJ
10_1101-2020_09_09_289074	33	9	RBD	RBD	NNP
10_1101-2020_09_09_289074	33	10	(	(	-LRB-
10_1101-2020_09_09_289074	33	11	AA	AA	NNP
10_1101-2020_09_09_289074	33	12	~330	~330	FW
10_1101-2020_09_09_289074	33	13	-	-	HYPH
10_1101-2020_09_09_289074	33	14	530	530	CD
10_1101-2020_09_09_289074	33	15	)	)	-RRB-
10_1101-2020_09_09_289074	33	16	,	,	,
10_1101-2020_09_09_289074	33	17	but	but	CC
10_1101-2020_09_09_289074	33	18	some	some	DT
10_1101-2020_09_09_289074	33	19	studies	study	NNS
10_1101-2020_09_09_289074	33	20	suggest	suggest	VBP
10_1101-2020_09_09_289074	33	21	it	-PRON-	PRP
10_1101-2020_09_09_289074	33	22	may	may	MD
10_1101-2020_09_09_289074	33	23	have	have	VB
10_1101-2020_09_09_289074	33	24	a	a	DT
10_1101-2020_09_09_289074	33	25	clinically	clinically	RB
10_1101-2020_09_09_289074	33	26	relevant	relevant	JJ
10_1101-2020_09_09_289074	33	27	role	role	NN
10_1101-2020_09_09_289074	33	28	:	:	:
10_1101-2020_09_09_289074	33	29	D614	D614	NNP
10_1101-2020_09_09_289074	33	30	G	g	NN
10_1101-2020_09_09_289074	33	31	is	be	VBZ
10_1101-2020_09_09_289074	33	32	positively	positively	RB
10_1101-2020_09_09_289074	33	33	correlated	correlate	VBN
10_1101-2020_09_09_289074	33	34	with	with	IN
10_1101-2020_09_09_289074	33	35	increased	increase	VBN
10_1101-2020_09_09_289074	33	36	case	case	NN
10_1101-2020_09_09_289074	33	37	fatality	fatality	NN
10_1101-2020_09_09_289074	33	38	rate	rate	NN
10_1101-2020_09_09_289074	33	39	(	(	-LRB-
10_1101-2020_09_09_289074	33	40	19	19	CD
10_1101-2020_09_09_289074	33	41	)	)	-RRB-
10_1101-2020_09_09_289074	33	42	,	,	,
10_1101-2020_09_09_289074	33	43	and	and	CC
10_1101-2020_09_09_289074	33	44	it	-PRON-	PRP
10_1101-2020_09_09_289074	33	45	shows	show	VBZ
10_1101-2020_09_09_289074	33	46	increased	increase	VBN
10_1101-2020_09_09_289074	33	47	transmissibility	transmissibility	NN
10_1101-2020_09_09_289074	33	48	and	and	CC
10_1101-2020_09_09_289074	33	49	infectivity	infectivity	NN
10_1101-2020_09_09_289074	33	50	compared	compare	VBN
10_1101-2020_09_09_289074	33	51	to	to	IN
10_1101-2020_09_09_289074	33	52	the	the	DT
10_1101-2020_09_09_289074	33	53	reference	reference	NN
10_1101-2020_09_09_289074	33	54	genome	genome	JJ
10_1101-2020_09_09_289074	33	55	(	(	-LRB-
10_1101-2020_09_09_289074	33	56	20	20	CD
10_1101-2020_09_09_289074	33	57	)	)	-RRB-
10_1101-2020_09_09_289074	33	58	.	.	.
10_1101-2020_09_09_289074	34	1	In	in	IN
10_1101-2020_09_09_289074	34	2	vitro	vitro	FW
10_1101-2020_09_09_289074	34	3	studies	study	NNS
10_1101-2020_09_09_289074	34	4	show	show	VBP
10_1101-2020_09_09_289074	34	5	that	that	IN
10_1101-2020_09_09_289074	34	6	viruses	virus	NNS
10_1101-2020_09_09_289074	34	7	carrying	carry	VBG
10_1101-2020_09_09_289074	34	8	the	the	DT
10_1101-2020_09_09_289074	34	9	D614	D614	NNP
10_1101-2020_09_09_289074	34	10	G	G	NNP
10_1101-2020_09_09_289074	34	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	34	12	mutation	mutation	NN
10_1101-2020_09_09_289074	34	13	have	have	VBP
10_1101-2020_09_09_289074	34	14	an	an	DT
10_1101-2020_09_09_289074	34	15	increased	increase	VBN
10_1101-2020_09_09_289074	34	16	viral	viral	JJ
10_1101-2020_09_09_289074	34	17	load	load	NN
10_1101-2020_09_09_289074	34	18	and	and	CC
10_1101-2020_09_09_289074	34	19	cytopathic	cytopathic	JJ
10_1101-2020_09_09_289074	34	20	effect	effect	NN
10_1101-2020_09_09_289074	34	21	in	in	IN
10_1101-2020_09_09_289074	34	22	cultured	cultured	JJ
10_1101-2020_09_09_289074	34	23	Vero	Vero	NNP
10_1101-2020_09_09_289074	34	24	cells	cell	NNS
10_1101-2020_09_09_289074	34	25	(	(	-LRB-
10_1101-2020_09_09_289074	34	26	16	16	CD
10_1101-2020_09_09_289074	34	27	)	)	-RRB-
10_1101-2020_09_09_289074	34	28	.	.	.
10_1101-2020_09_09_289074	35	1	Despite	despite	IN
10_1101-2020_09_09_289074	35	2	these	these	DT
10_1101-2020_09_09_289074	35	3	preliminary	preliminary	JJ
10_1101-2020_09_09_289074	35	4	observations	observation	NNS
10_1101-2020_09_09_289074	35	5	,	,	,
10_1101-2020_09_09_289074	35	6	there	there	EX
10_1101-2020_09_09_289074	35	7	are	be	VBP
10_1101-2020_09_09_289074	35	8	still	still	RB
10_1101-2020_09_09_289074	35	9	several	several	JJ
10_1101-2020_09_09_289074	35	10	doubts	doubt	NNS
10_1101-2020_09_09_289074	35	11	on	on	IN
10_1101-2020_09_09_289074	35	12	the	the	DT
10_1101-2020_09_09_289074	35	13	molecular	molecular	JJ
10_1101-2020_09_09_289074	35	14	effects	effect	NNS
10_1101-2020_09_09_289074	35	15	of	of	IN
10_1101-2020_09_09_289074	35	16	the	the	DT
10_1101-2020_09_09_289074	35	17	D614	D614	NNP
10_1101-2020_09_09_289074	35	18	G	G	NNP
10_1101-2020_09_09_289074	35	19	variant	variant	NN
10_1101-2020_09_09_289074	35	20	(	(	-LRB-
10_1101-2020_09_09_289074	35	21	21	21	CD
10_1101-2020_09_09_289074	35	22	)	)	-RRB-
10_1101-2020_09_09_289074	35	23	.	.	.
10_1101-2020_09_09_289074	36	1	Other	other	JJ
10_1101-2020_09_09_289074	36	2	recurring	recur	VBG
10_1101-2020_09_09_289074	36	3	Spike	Spike	NNP
10_1101-2020_09_09_289074	36	4	mutations	mutation	NNS
10_1101-2020_09_09_289074	36	5	have	have	VBP
10_1101-2020_09_09_289074	36	6	been	be	VBN
10_1101-2020_09_09_289074	36	7	observed	observe	VBN
10_1101-2020_09_09_289074	36	8	in	in	IN
10_1101-2020_09_09_289074	36	9	the	the	DT
10_1101-2020_09_09_289074	36	10	population	population	NN
10_1101-2020_09_09_289074	36	11	worldwide	worldwide	RB
10_1101-2020_09_09_289074	36	12	,	,	,
10_1101-2020_09_09_289074	36	13	however	however	RB
10_1101-2020_09_09_289074	36	14	at	at	IN
10_1101-2020_09_09_289074	36	15	frequencies	frequency	NNS
10_1101-2020_09_09_289074	36	16	of	of	IN
10_1101-2020_09_09_289074	36	17	1	1	CD
10_1101-2020_09_09_289074	36	18	%	%	NN
10_1101-2020_09_09_289074	36	19	or	or	CC
10_1101-2020_09_09_289074	36	20	below	below	IN
10_1101-2020_09_09_289074	36	21	(	(	-LRB-
10_1101-2020_09_09_289074	36	22	3	3	CD
10_1101-2020_09_09_289074	36	23	)	)	-RRB-
10_1101-2020_09_09_289074	36	24	;	;	:
10_1101-2020_09_09_289074	36	25	some	some	DT
10_1101-2020_09_09_289074	36	26	of	of	IN
10_1101-2020_09_09_289074	36	27	these	these	DT
10_1101-2020_09_09_289074	36	28	mutations	mutation	NNS
10_1101-2020_09_09_289074	36	29	fall	fall	VBP
10_1101-2020_09_09_289074	36	30	within	within	IN
10_1101-2020_09_09_289074	36	31	the	the	DT
10_1101-2020_09_09_289074	36	32	RBD	rbd	NN
10_1101-2020_09_09_289074	36	33	and	and	CC
10_1101-2020_09_09_289074	36	34	therefore	therefore	RB
10_1101-2020_09_09_289074	36	35	may	may	MD
10_1101-2020_09_09_289074	36	36	have	have	VB
10_1101-2020_09_09_289074	36	37	a	a	DT
10_1101-2020_09_09_289074	36	38	direct	direct	JJ
10_1101-2020_09_09_289074	36	39	role	role	NN
10_1101-2020_09_09_289074	36	40	in	in	IN
10_1101-2020_09_09_289074	36	41	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	36	42	interaction	interaction	NN
10_1101-2020_09_09_289074	36	43	.	.	.
10_1101-2020_09_09_289074	37	1	On	on	IN
10_1101-2020_09_09_289074	37	2	the	the	DT
10_1101-2020_09_09_289074	37	3	other	other	JJ
10_1101-2020_09_09_289074	37	4	hand	hand	NN
10_1101-2020_09_09_289074	37	5	,	,	,
10_1101-2020_09_09_289074	37	6	genetic	genetic	JJ
10_1101-2020_09_09_289074	37	7	variants	variant	NNS
10_1101-2020_09_09_289074	37	8	of	of	IN
10_1101-2020_09_09_289074	37	9	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	37	10	in	in	IN
10_1101-2020_09_09_289074	37	11	human	human	JJ
10_1101-2020_09_09_289074	37	12	population	population	NN
10_1101-2020_09_09_289074	37	13	may	may	MD
10_1101-2020_09_09_289074	37	14	influence	influence	VB
10_1101-2020_09_09_289074	37	15	susceptibility	susceptibility	NN
10_1101-2020_09_09_289074	37	16	or	or	CC
10_1101-2020_09_09_289074	37	17	resistance	resistance	NN
10_1101-2020_09_09_289074	37	18	to	to	IN
10_1101-2020_09_09_289074	37	19	SARS	SARS	NNP
10_1101-2020_09_09_289074	37	20	-	-	HYPH
10_1101-2020_09_09_289074	37	21	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	37	22	infection	infection	NN
10_1101-2020_09_09_289074	37	23	,	,	,
10_1101-2020_09_09_289074	37	24	possibly	possibly	RB
10_1101-2020_09_09_289074	37	25	contributing	contribute	VBG
10_1101-2020_09_09_289074	37	26	to	to	IN
10_1101-2020_09_09_289074	37	27	the	the	DT
10_1101-2020_09_09_289074	37	28	difference	difference	NN
10_1101-2020_09_09_289074	37	29	in	in	IN
10_1101-2020_09_09_289074	37	30	clinical	clinical	JJ
10_1101-2020_09_09_289074	37	31	features	feature	NNS
10_1101-2020_09_09_289074	37	32	observed	observe	VBN
10_1101-2020_09_09_289074	37	33	in	in	IN
10_1101-2020_09_09_289074	37	34	COVID-19	covid-19	JJ
10_1101-2020_09_09_289074	37	35	patients	patient	NNS
10_1101-2020_09_09_289074	37	36	(	(	-LRB-
10_1101-2020_09_09_289074	37	37	22	22	CD
10_1101-2020_09_09_289074	37	38	)	)	-RRB-
10_1101-2020_09_09_289074	37	39	.	.	.
10_1101-2020_09_09_289074	38	1	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	38	2	gene	gene	NN
10_1101-2020_09_09_289074	38	3	is	be	VBZ
10_1101-2020_09_09_289074	38	4	located	locate	VBN
10_1101-2020_09_09_289074	38	5	on	on	IN
10_1101-2020_09_09_289074	38	6	chromosome	chromosome	NN
10_1101-2020_09_09_289074	38	7	Xp22.2	Xp22.2	NNS
10_1101-2020_09_09_289074	38	8	and	and	CC
10_1101-2020_09_09_289074	38	9	consists	consist	VBZ
10_1101-2020_09_09_289074	38	10	of	of	IN
10_1101-2020_09_09_289074	38	11	18	18	CD
10_1101-2020_09_09_289074	38	12	exons	exon	NNS
10_1101-2020_09_09_289074	38	13	,	,	,
10_1101-2020_09_09_289074	38	14	coding	code	VBG
10_1101-2020_09_09_289074	38	15	for	for	IN
10_1101-2020_09_09_289074	38	16	an	an	DT
10_1101-2020_09_09_289074	38	17	805	805	CD
10_1101-2020_09_09_289074	38	18	AAs	aa	NNS
10_1101-2020_09_09_289074	38	19	long	long	JJ
10_1101-2020_09_09_289074	38	20	protein	protein	NN
10_1101-2020_09_09_289074	38	21	exposed	expose	VBN
10_1101-2020_09_09_289074	38	22	on	on	IN
10_1101-2020_09_09_289074	38	23	the	the	DT
10_1101-2020_09_09_289074	38	24	cell	cell	NN
10_1101-2020_09_09_289074	38	25	surface	surface	NN
10_1101-2020_09_09_289074	38	26	of	of	IN
10_1101-2020_09_09_289074	38	27	a	a	DT
10_1101-2020_09_09_289074	38	28	variety	variety	NN
10_1101-2020_09_09_289074	38	29	of	of	IN
10_1101-2020_09_09_289074	38	30	human	human	JJ
10_1101-2020_09_09_289074	38	31	organs	organ	NNS
10_1101-2020_09_09_289074	38	32	,	,	,
10_1101-2020_09_09_289074	38	33	including	include	VBG
10_1101-2020_09_09_289074	38	34	kidneys	kidney	NNS
10_1101-2020_09_09_289074	38	35	,	,	,
10_1101-2020_09_09_289074	38	36	heart	heart	NN
10_1101-2020_09_09_289074	38	37	,	,	,
10_1101-2020_09_09_289074	38	38	brain	brain	NN
10_1101-2020_09_09_289074	38	39	,	,	,
10_1101-2020_09_09_289074	38	40	gastrointestinal	gastrointestinal	JJ
10_1101-2020_09_09_289074	38	41	tract	tract	NN
10_1101-2020_09_09_289074	38	42	,	,	,
10_1101-2020_09_09_289074	38	43	and	and	CC
10_1101-2020_09_09_289074	38	44	lungs	lung	NNS
10_1101-2020_09_09_289074	38	45	(	(	-LRB-
10_1101-2020_09_09_289074	38	46	23	23	CD
10_1101-2020_09_09_289074	38	47	)	)	-RRB-
10_1101-2020_09_09_289074	38	48	.	.	.
10_1101-2020_09_09_289074	39	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	39	2	is	be	VBZ
10_1101-2020_09_09_289074	39	3	unclear	unclear	JJ
10_1101-2020_09_09_289074	39	4	if	if	IN
10_1101-2020_09_09_289074	39	5	tissue	tissue	NN
10_1101-2020_09_09_289074	39	6	-	-	HYPH
10_1101-2020_09_09_289074	39	7	expression	expression	NN
10_1101-2020_09_09_289074	39	8	patterns	pattern	NNS
10_1101-2020_09_09_289074	39	9	of	of	IN
10_1101-2020_09_09_289074	39	10	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	39	11	may	may	MD
10_1101-2020_09_09_289074	39	12	be	be	VB
10_1101-2020_09_09_289074	39	13	linked	link	VBN
10_1101-2020_09_09_289074	39	14	to	to	IN
10_1101-2020_09_09_289074	39	15	the	the	DT
10_1101-2020_09_09_289074	39	16	severity	severity	NN
10_1101-2020_09_09_289074	39	17	of	of	IN
10_1101-2020_09_09_289074	39	18	symptoms	symptom	NNS
10_1101-2020_09_09_289074	39	19	or	or	CC
10_1101-2020_09_09_289074	39	20	outcomes	outcome	NNS
10_1101-2020_09_09_289074	39	21	of	of	IN
10_1101-2020_09_09_289074	39	22	SARS	SARS	NNP
10_1101-2020_09_09_289074	39	23	-	-	HYPH
10_1101-2020_09_09_289074	39	24	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	39	25	infections	infection	NNS
10_1101-2020_09_09_289074	39	26	;	;	:
10_1101-2020_09_09_289074	39	27	however	however	RB
10_1101-2020_09_09_289074	39	28	,	,	,
10_1101-2020_09_09_289074	39	29	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	39	30	levels	level	NNS
10_1101-2020_09_09_289074	39	31	in	in	IN
10_1101-2020_09_09_289074	39	32	lungs	lung	NNS
10_1101-2020_09_09_289074	39	33	were	be	VBD
10_1101-2020_09_09_289074	39	34	found	find	VBN
10_1101-2020_09_09_289074	39	35	to	to	TO
10_1101-2020_09_09_289074	39	36	be	be	VB
10_1101-2020_09_09_289074	39	37	increased	increase	VBN
10_1101-2020_09_09_289074	39	38	in	in	IN
10_1101-2020_09_09_289074	39	39	patients	patient	NNS
10_1101-2020_09_09_289074	39	40	with	with	IN
10_1101-2020_09_09_289074	39	41	comorbidities	comorbiditie	NNS
10_1101-2020_09_09_289074	39	42	associated	associate	VBN
10_1101-2020_09_09_289074	39	43	to	to	IN
10_1101-2020_09_09_289074	39	44	severe	severe	JJ
10_1101-2020_09_09_289074	39	45	COVID-19	COVID-19	,
10_1101-2020_09_09_289074	39	46	clinical	clinical	JJ
10_1101-2020_09_09_289074	39	47	manifestations	manifestation	NNS
10_1101-2020_09_09_289074	39	48	(	(	-LRB-
10_1101-2020_09_09_289074	39	49	24	24	CD
10_1101-2020_09_09_289074	39	50	)	)	-RRB-
10_1101-2020_09_09_289074	39	51	,	,	,
10_1101-2020_09_09_289074	39	52	whereas	whereas	IN
10_1101-2020_09_09_289074	39	53	polymorphisms	polymorphism	NNS
10_1101-2020_09_09_289074	39	54	of	of	IN
10_1101-2020_09_09_289074	39	55	ACE2	ACE2	NNS
10_1101-2020_09_09_289074	39	56	have	have	VBP
10_1101-2020_09_09_289074	39	57	been	be	VBN
10_1101-2020_09_09_289074	39	58	already	already	RB
10_1101-2020_09_09_289074	39	59	described	describe	VBN
10_1101-2020_09_09_289074	39	60	to	to	TO
10_1101-2020_09_09_289074	39	61	play	play	VB
10_1101-2020_09_09_289074	39	62	a	a	DT
10_1101-2020_09_09_289074	39	63	role	role	NN
10_1101-2020_09_09_289074	39	64	in	in	IN
10_1101-2020_09_09_289074	39	65	hypertension	hypertension	NN
10_1101-2020_09_09_289074	39	66	and	and	CC
10_1101-2020_09_09_289074	39	67	cardiovascular	cardiovascular	JJ
10_1101-2020_09_09_289074	39	68	diseases	disease	NNS
10_1101-2020_09_09_289074	39	69	(	(	-LRB-
10_1101-2020_09_09_289074	39	70	25	25	CD
10_1101-2020_09_09_289074	39	71	)	)	-RRB-
10_1101-2020_09_09_289074	39	72	,	,	,
10_1101-2020_09_09_289074	39	73	particularly	particularly	RB
10_1101-2020_09_09_289074	39	74	in	in	IN
10_1101-2020_09_09_289074	39	75	association	association	NN
10_1101-2020_09_09_289074	39	76	with	with	IN
10_1101-2020_09_09_289074	39	77	type	type	NN
10_1101-2020_09_09_289074	39	78	2	2	CD
10_1101-2020_09_09_289074	39	79	diabetes	diabetes	NN
10_1101-2020_09_09_289074	39	80	(	(	-LRB-
10_1101-2020_09_09_289074	39	81	23	23	CD
10_1101-2020_09_09_289074	39	82	)	)	-RRB-
10_1101-2020_09_09_289074	39	83	,	,	,
10_1101-2020_09_09_289074	39	84	all	all	DT
10_1101-2020_09_09_289074	39	85	conditions	condition	NNS
10_1101-2020_09_09_289074	39	86	predisposing	predispose	VBG
10_1101-2020_09_09_289074	39	87	to	to	IN
10_1101-2020_09_09_289074	39	88	an	an	DT
10_1101-2020_09_09_289074	39	89	increased	increase	VBN
10_1101-2020_09_09_289074	39	90	risk	risk	NN
10_1101-2020_09_09_289074	39	91	of	of	IN
10_1101-2020_09_09_289074	39	92	dying	die	VBG
10_1101-2020_09_09_289074	39	93	from	from	IN
10_1101-2020_09_09_289074	39	94	COVID-19	covid-19	JJ
10_1101-2020_09_09_289074	39	95	(	(	-LRB-
10_1101-2020_09_09_289074	39	96	26	26	CD
10_1101-2020_09_09_289074	39	97	)	)	-RRB-
10_1101-2020_09_09_289074	39	98	.	.	.
10_1101-2020_09_09_289074	40	1	Despite	despite	IN
10_1101-2020_09_09_289074	40	2	early	early	JJ
10_1101-2020_09_09_289074	40	3	studies	study	NNS
10_1101-2020_09_09_289074	40	4	,	,	,
10_1101-2020_09_09_289074	40	5	the	the	DT
10_1101-2020_09_09_289074	40	6	presence	presence	NN
10_1101-2020_09_09_289074	40	7	of	of	IN
10_1101-2020_09_09_289074	40	8	Spike	Spike	NNP
10_1101-2020_09_09_289074	40	9	mutations	mutation	NNS
10_1101-2020_09_09_289074	40	10	potentially	potentially	RB
10_1101-2020_09_09_289074	40	11	altering	alter	VBG
10_1101-2020_09_09_289074	40	12	the	the	DT
10_1101-2020_09_09_289074	40	13	binding	binding	NN
10_1101-2020_09_09_289074	40	14	with	with	IN
10_1101-2020_09_09_289074	40	15	.CC	.CC	NFP
10_1101-2020_09_09_289074	40	16	-	-	HYPH
10_1101-2020_09_09_289074	40	17	BY	by	IN
10_1101-2020_09_09_289074	40	18	-	-	HYPH
10_1101-2020_09_09_289074	40	19	NC	NC	NNP
10_1101-2020_09_09_289074	40	20	-	-	HYPH
10_1101-2020_09_09_289074	40	21	ND	ND	NNP
10_1101-2020_09_09_289074	40	22	4.0	4.0	CD
10_1101-2020_09_09_289074	40	23	International	International	NNP
10_1101-2020_09_09_289074	40	24	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	40	25	under	under	IN
10_1101-2020_09_09_289074	40	26	a	a	DT
10_1101-2020_09_09_289074	40	27	(	(	-LRB-
10_1101-2020_09_09_289074	40	28	which	which	WDT
10_1101-2020_09_09_289074	40	29	was	be	VBD
10_1101-2020_09_09_289074	40	30	not	not	RB
10_1101-2020_09_09_289074	40	31	certified	certify	VBN
10_1101-2020_09_09_289074	40	32	by	by	IN
10_1101-2020_09_09_289074	40	33	peer	peer	NN
10_1101-2020_09_09_289074	40	34	review	review	NN
10_1101-2020_09_09_289074	40	35	)	)	-RRB-
10_1101-2020_09_09_289074	40	36	is	be	VBZ
10_1101-2020_09_09_289074	40	37	the	the	DT
10_1101-2020_09_09_289074	40	38	author	author	NN
10_1101-2020_09_09_289074	40	39	/	/	SYM
10_1101-2020_09_09_289074	40	40	funder	funder	NN
10_1101-2020_09_09_289074	40	41	,	,	,
10_1101-2020_09_09_289074	40	42	who	who	WP
10_1101-2020_09_09_289074	40	43	has	have	VBZ
10_1101-2020_09_09_289074	40	44	granted	grant	VBN
10_1101-2020_09_09_289074	40	45	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	40	46	a	a	DT
10_1101-2020_09_09_289074	40	47	license	license	NN
10_1101-2020_09_09_289074	40	48	to	to	TO
10_1101-2020_09_09_289074	40	49	display	display	VB
10_1101-2020_09_09_289074	40	50	the	the	DT
10_1101-2020_09_09_289074	40	51	preprint	preprint	NN
10_1101-2020_09_09_289074	40	52	in	in	IN
10_1101-2020_09_09_289074	40	53	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	40	54	.	.	.
10_1101-2020_09_09_289074	41	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	41	2	is	be	VBZ
10_1101-2020_09_09_289074	41	3	made	make	VBN
10_1101-2020_09_09_289074	41	4	The	the	DT
10_1101-2020_09_09_289074	41	5	copyright	copyright	NN
10_1101-2020_09_09_289074	41	6	holder	holder	NN
10_1101-2020_09_09_289074	41	7	for	for	IN
10_1101-2020_09_09_289074	41	8	this	this	DT
10_1101-2020_09_09_289074	41	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	41	10	version	version	NN
10_1101-2020_09_09_289074	41	11	posted	post	VBD
10_1101-2020_09_09_289074	41	12	January	January	NNP
10_1101-2020_09_09_289074	41	13	5	5	CD
10_1101-2020_09_09_289074	41	14	,	,	,
10_1101-2020_09_09_289074	41	15	2021	2021	CD
10_1101-2020_09_09_289074	41	16	.	.	.
10_1101-2020_09_09_289074	41	17	;	;	:
10_1101-2020_09_09_289074	41	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	41	19	:	:	:
10_1101-2020_09_09_289074	41	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	41	21	preprint	preprint	NN
10_1101-2020_09_09_289074	41	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	41	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	41	24	4	4	CD
10_1101-2020_09_09_289074	41	25	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	41	26	is	be	VBZ
10_1101-2020_09_09_289074	41	27	still	still	RB
10_1101-2020_09_09_289074	41	28	largely	largely	RB
10_1101-2020_09_09_289074	41	29	under	under	RB
10_1101-2020_09_09_289074	41	30	-	-	HYPH
10_1101-2020_09_09_289074	41	31	investigated	investigate	VBN
10_1101-2020_09_09_289074	41	32	,	,	,
10_1101-2020_09_09_289074	41	33	as	as	IN
10_1101-2020_09_09_289074	41	34	is	be	VBZ
10_1101-2020_09_09_289074	41	35	the	the	DT
10_1101-2020_09_09_289074	41	36	role	role	NN
10_1101-2020_09_09_289074	41	37	of	of	IN
10_1101-2020_09_09_289074	41	38	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	41	39	variants	variant	NNS
10_1101-2020_09_09_289074	41	40	in	in	IN
10_1101-2020_09_09_289074	41	41	the	the	DT
10_1101-2020_09_09_289074	41	42	human	human	JJ
10_1101-2020_09_09_289074	41	43	population	population	NN
10_1101-2020_09_09_289074	41	44	in	in	IN
10_1101-2020_09_09_289074	41	45	determining	determine	VBG
10_1101-2020_09_09_289074	41	46	patient	patient	NN
10_1101-2020_09_09_289074	41	47	-	-	HYPH
10_1101-2020_09_09_289074	41	48	specific	specific	JJ
10_1101-2020_09_09_289074	41	49	molecular	molecular	JJ
10_1101-2020_09_09_289074	41	50	interactions	interaction	NNS
10_1101-2020_09_09_289074	41	51	between	between	IN
10_1101-2020_09_09_289074	41	52	these	these	DT
10_1101-2020_09_09_289074	41	53	two	two	CD
10_1101-2020_09_09_289074	41	54	proteins	protein	NNS
10_1101-2020_09_09_289074	41	55	.	.	.
10_1101-2020_09_09_289074	42	1	In	in	IN
10_1101-2020_09_09_289074	42	2	the	the	DT
10_1101-2020_09_09_289074	42	3	present	present	JJ
10_1101-2020_09_09_289074	42	4	study	study	NN
10_1101-2020_09_09_289074	42	5	,	,	,
10_1101-2020_09_09_289074	42	6	we	-PRON-	PRP
10_1101-2020_09_09_289074	42	7	aim	aim	VBP
10_1101-2020_09_09_289074	42	8	at	at	IN
10_1101-2020_09_09_289074	42	9	detecting	detect	VBG
10_1101-2020_09_09_289074	42	10	which	which	WDT
10_1101-2020_09_09_289074	42	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	42	12	and	and	CC
10_1101-2020_09_09_289074	42	13	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	42	14	AAs	aa	NNS
10_1101-2020_09_09_289074	42	15	are	be	VBP
10_1101-2020_09_09_289074	42	16	the	the	DT
10_1101-2020_09_09_289074	42	17	most	most	RBS
10_1101-2020_09_09_289074	42	18	important	important	JJ
10_1101-2020_09_09_289074	42	19	in	in	IN
10_1101-2020_09_09_289074	42	20	determining	determine	VBG
10_1101-2020_09_09_289074	42	21	the	the	DT
10_1101-2020_09_09_289074	42	22	SARS	SARS	NNP
10_1101-2020_09_09_289074	42	23	-	-	HYPH
10_1101-2020_09_09_289074	42	24	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	42	25	entry	entry	NNP
10_1101-2020_09_09_289074	42	26	interaction	interaction	NN
10_1101-2020_09_09_289074	42	27	and	and	CC
10_1101-2020_09_09_289074	42	28	analyze	analyze	VB
10_1101-2020_09_09_289074	42	29	which	which	WDT
10_1101-2020_09_09_289074	42	30	ones	one	NNS
10_1101-2020_09_09_289074	42	31	have	have	VBP
10_1101-2020_09_09_289074	42	32	already	already	RB
10_1101-2020_09_09_289074	42	33	mutated	mutate	VBN
10_1101-2020_09_09_289074	42	34	in	in	IN
10_1101-2020_09_09_289074	42	35	the	the	DT
10_1101-2020_09_09_289074	42	36	population	population	NN
10_1101-2020_09_09_289074	42	37	.	.	.
10_1101-2020_09_09_289074	43	1	The	the	DT
10_1101-2020_09_09_289074	43	2	task	task	NN
10_1101-2020_09_09_289074	43	3	is	be	VBZ
10_1101-2020_09_09_289074	43	4	clinically	clinically	RB
10_1101-2020_09_09_289074	43	5	relevant	relevant	JJ
10_1101-2020_09_09_289074	43	6	,	,	,
10_1101-2020_09_09_289074	43	7	providing	provide	VBG
10_1101-2020_09_09_289074	43	8	a	a	DT
10_1101-2020_09_09_289074	43	9	functional	functional	JJ
10_1101-2020_09_09_289074	43	10	characterization	characterization	NN
10_1101-2020_09_09_289074	43	11	of	of	IN
10_1101-2020_09_09_289074	43	12	present	present	JJ
10_1101-2020_09_09_289074	43	13	and	and	CC
10_1101-2020_09_09_289074	43	14	future	future	JJ
10_1101-2020_09_09_289074	43	15	mutations	mutation	NNS
10_1101-2020_09_09_289074	43	16	targeting	target	VBG
10_1101-2020_09_09_289074	43	17	the	the	DT
10_1101-2020_09_09_289074	43	18	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	43	19	/	/	SYM
10_1101-2020_09_09_289074	43	20	Spike	Spike	NNP
10_1101-2020_09_09_289074	43	21	binding	bind	VBG
10_1101-2020_09_09_289074	43	22	and	and	CC
10_1101-2020_09_09_289074	43	23	detected	detect	VBN
10_1101-2020_09_09_289074	43	24	by	by	IN
10_1101-2020_09_09_289074	43	25	sequencing	sequence	VBG
10_1101-2020_09_09_289074	43	26	SARS	SARS	NNP
10_1101-2020_09_09_289074	43	27	-	-	HYPH
10_1101-2020_09_09_289074	43	28	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	43	29	on	on	IN
10_1101-2020_09_09_289074	43	30	a	a	DT
10_1101-2020_09_09_289074	43	31	patient	patient	NN
10_1101-2020_09_09_289074	43	32	-	-	HYPH
10_1101-2020_09_09_289074	43	33	specific	specific	JJ
10_1101-2020_09_09_289074	43	34	basis	basis	NN
10_1101-2020_09_09_289074	43	35	.	.	.
10_1101-2020_09_09_289074	44	1	Characterizing	characterize	VBG
10_1101-2020_09_09_289074	44	2	the	the	DT
10_1101-2020_09_09_289074	44	3	variability	variability	NN
10_1101-2020_09_09_289074	44	4	of	of	IN
10_1101-2020_09_09_289074	44	5	both	both	DT
10_1101-2020_09_09_289074	44	6	proteins	protein	NNS
10_1101-2020_09_09_289074	44	7	must	must	MD
10_1101-2020_09_09_289074	44	8	be	be	VB
10_1101-2020_09_09_289074	44	9	taken	take	VBN
10_1101-2020_09_09_289074	44	10	in	in	IN
10_1101-2020_09_09_289074	44	11	consideration	consideration	NN
10_1101-2020_09_09_289074	44	12	in	in	IN
10_1101-2020_09_09_289074	44	13	the	the	DT
10_1101-2020_09_09_289074	44	14	process	process	NN
10_1101-2020_09_09_289074	44	15	of	of	IN
10_1101-2020_09_09_289074	44	16	developing	develop	VBG
10_1101-2020_09_09_289074	44	17	anti	anti	JJ
10_1101-2020_09_09_289074	44	18	-	-	JJ
10_1101-2020_09_09_289074	44	19	COVID-19	covid-19	JJ
10_1101-2020_09_09_289074	44	20	strategies	strategy	NNS
10_1101-2020_09_09_289074	44	21	,	,	,
10_1101-2020_09_09_289074	44	22	such	such	JJ
10_1101-2020_09_09_289074	44	23	as	as	IN
10_1101-2020_09_09_289074	44	24	the	the	DT
10_1101-2020_09_09_289074	44	25	Spike	Spike	NNP
10_1101-2020_09_09_289074	44	26	-	-	HYPH
10_1101-2020_09_09_289074	44	27	based	base	VBN
10_1101-2020_09_09_289074	44	28	vaccine	vaccine	NN
10_1101-2020_09_09_289074	44	29	currently	currently	RB
10_1101-2020_09_09_289074	44	30	deployed	deploy	VBN
10_1101-2020_09_09_289074	44	31	by	by	IN
10_1101-2020_09_09_289074	44	32	the	the	DT
10_1101-2020_09_09_289074	44	33	National	National	NNP
10_1101-2020_09_09_289074	44	34	Institute	Institute	NNP
10_1101-2020_09_09_289074	44	35	of	of	IN
10_1101-2020_09_09_289074	44	36	Allergy	Allergy	NNP
10_1101-2020_09_09_289074	44	37	and	and	CC
10_1101-2020_09_09_289074	44	38	Infectious	Infectious	NNP
10_1101-2020_09_09_289074	44	39	Diseases	Diseases	NNPS
10_1101-2020_09_09_289074	44	40	and	and	CC
10_1101-2020_09_09_289074	44	41	Moderna	Moderna	NNP
10_1101-2020_09_09_289074	44	42	(	(	-LRB-
10_1101-2020_09_09_289074	44	43	27	27	CD
10_1101-2020_09_09_289074	44	44	)	)	-RRB-
10_1101-2020_09_09_289074	44	45	.	.	.
10_1101-2020_09_09_289074	45	1	Results	result	NNS
10_1101-2020_09_09_289074	45	2	We	-PRON-	PRP
10_1101-2020_09_09_289074	45	3	set	set	VBD
10_1101-2020_09_09_289074	45	4	out	out	RP
10_1101-2020_09_09_289074	45	5	to	to	TO
10_1101-2020_09_09_289074	45	6	analyze	analyze	VB
10_1101-2020_09_09_289074	45	7	the	the	DT
10_1101-2020_09_09_289074	45	8	key	key	JJ
10_1101-2020_09_09_289074	45	9	AAs	aa	NNS
10_1101-2020_09_09_289074	45	10	involved	involve	VBN
10_1101-2020_09_09_289074	45	11	in	in	IN
10_1101-2020_09_09_289074	45	12	the	the	DT
10_1101-2020_09_09_289074	45	13	Spike	Spike	NNP
10_1101-2020_09_09_289074	45	14	/	/	SYM
10_1101-2020_09_09_289074	45	15	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	45	16	interaction	interaction	NN
10_1101-2020_09_09_289074	45	17	,	,	,
10_1101-2020_09_09_289074	45	18	in	in	IN
10_1101-2020_09_09_289074	45	19	order	order	NN
10_1101-2020_09_09_289074	45	20	to	to	TO
10_1101-2020_09_09_289074	45	21	highlight	highlight	VB
10_1101-2020_09_09_289074	45	22	which	which	WDT
10_1101-2020_09_09_289074	45	23	ones	one	NNS
10_1101-2020_09_09_289074	45	24	may	may	MD
10_1101-2020_09_09_289074	45	25	alter	alter	VB
10_1101-2020_09_09_289074	45	26	the	the	DT
10_1101-2020_09_09_289074	45	27	binding	bind	VBG
10_1101-2020_09_09_289074	45	28	affinity	affinity	NN
10_1101-2020_09_09_289074	45	29	and	and	CC
10_1101-2020_09_09_289074	45	30	therefore	therefore	RB
10_1101-2020_09_09_289074	45	31	etiological	etiological	JJ
10_1101-2020_09_09_289074	45	32	and	and	CC
10_1101-2020_09_09_289074	45	33	clinical	clinical	JJ
10_1101-2020_09_09_289074	45	34	properties	property	NNS
10_1101-2020_09_09_289074	45	35	of	of	IN
10_1101-2020_09_09_289074	45	36	different	different	JJ
10_1101-2020_09_09_289074	45	37	SARS-	SARS-	NNP
10_1101-2020_09_09_289074	45	38	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	45	39	variants	variant	NNS
10_1101-2020_09_09_289074	45	40	on	on	IN
10_1101-2020_09_09_289074	45	41	different	different	JJ
10_1101-2020_09_09_289074	45	42	patients	patient	NNS
10_1101-2020_09_09_289074	45	43	.	.	.
10_1101-2020_09_09_289074	46	1	Following	follow	VBG
10_1101-2020_09_09_289074	46	2	that	that	DT
10_1101-2020_09_09_289074	46	3	,	,	,
10_1101-2020_09_09_289074	46	4	we	-PRON-	PRP
10_1101-2020_09_09_289074	46	5	determined	determine	VBD
10_1101-2020_09_09_289074	46	6	which	which	WDT
10_1101-2020_09_09_289074	46	7	Spike	Spike	NNP
10_1101-2020_09_09_289074	46	8	and	and	CC
10_1101-2020_09_09_289074	46	9	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	46	10	AA	AA	NNP
10_1101-2020_09_09_289074	46	11	variations	variation	NNS
10_1101-2020_09_09_289074	46	12	relevant	relevant	JJ
10_1101-2020_09_09_289074	46	13	for	for	IN
10_1101-2020_09_09_289074	46	14	this	this	DT
10_1101-2020_09_09_289074	46	15	interaction	interaction	NN
10_1101-2020_09_09_289074	46	16	have	have	VBP
10_1101-2020_09_09_289074	46	17	been	be	VBN
10_1101-2020_09_09_289074	46	18	observed	observe	VBN
10_1101-2020_09_09_289074	46	19	in	in	IN
10_1101-2020_09_09_289074	46	20	the	the	DT
10_1101-2020_09_09_289074	46	21	SARS	SARS	NNP
10_1101-2020_09_09_289074	46	22	-	-	HYPH
10_1101-2020_09_09_289074	46	23	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	46	24	and	and	CC
10_1101-2020_09_09_289074	46	25	human	human	JJ
10_1101-2020_09_09_289074	46	26	population	population	NN
10_1101-2020_09_09_289074	46	27	,	,	,
10_1101-2020_09_09_289074	46	28	respectively	respectively	RB
10_1101-2020_09_09_289074	46	29	.	.	.
10_1101-2020_09_09_289074	47	1	Structural	structural	JJ
10_1101-2020_09_09_289074	47	2	analysis	analysis	NN
10_1101-2020_09_09_289074	47	3	of	of	IN
10_1101-2020_09_09_289074	47	4	Spike	Spike	NNP
10_1101-2020_09_09_289074	47	5	/	/	SYM
10_1101-2020_09_09_289074	47	6	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	47	7	interaction	interaction	NN
10_1101-2020_09_09_289074	47	8	We	-PRON-	PRP
10_1101-2020_09_09_289074	47	9	obtained	obtain	VBD
10_1101-2020_09_09_289074	47	10	structural	structural	JJ
10_1101-2020_09_09_289074	47	11	models	model	NNS
10_1101-2020_09_09_289074	47	12	of	of	IN
10_1101-2020_09_09_289074	47	13	the	the	DT
10_1101-2020_09_09_289074	47	14	SARS	SARS	NNP
10_1101-2020_09_09_289074	47	15	-	-	HYPH
10_1101-2020_09_09_289074	47	16	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	47	17	Spike	Spike	NNP
10_1101-2020_09_09_289074	47	18	interacting	interact	VBG
10_1101-2020_09_09_289074	47	19	with	with	IN
10_1101-2020_09_09_289074	47	20	the	the	DT
10_1101-2020_09_09_289074	47	21	human	human	JJ
10_1101-2020_09_09_289074	47	22	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	47	23	from	from	IN
10_1101-2020_09_09_289074	47	24	three	three	CD
10_1101-2020_09_09_289074	47	25	recent	recent	JJ
10_1101-2020_09_09_289074	47	26	X	x	NN
10_1101-2020_09_09_289074	47	27	-	-	NN
10_1101-2020_09_09_289074	47	28	ray	ray	NN
10_1101-2020_09_09_289074	47	29	structures	structure	NNS
10_1101-2020_09_09_289074	47	30	,	,	,
10_1101-2020_09_09_289074	47	31	deposited	deposit	VBN
10_1101-2020_09_09_289074	47	32	on	on	IN
10_1101-2020_09_09_289074	47	33	the	the	DT
10_1101-2020_09_09_289074	47	34	Protein	Protein	NNP
10_1101-2020_09_09_289074	47	35	Data	Data	NNPS
10_1101-2020_09_09_289074	47	36	Bank	Bank	NNP
10_1101-2020_09_09_289074	47	37	:	:	:
10_1101-2020_09_09_289074	47	38	6LZG	6LZG	NNP
10_1101-2020_09_09_289074	47	39	(	(	-LRB-
10_1101-2020_09_09_289074	47	40	10	10	CD
10_1101-2020_09_09_289074	47	41	)	)	-RRB-
10_1101-2020_09_09_289074	47	42	,	,	,
10_1101-2020_09_09_289074	47	43	6M0J	6m0j	CD
10_1101-2020_09_09_289074	47	44	(	(	-LRB-
10_1101-2020_09_09_289074	47	45	11	11	CD
10_1101-2020_09_09_289074	47	46	)	)	-RRB-
10_1101-2020_09_09_289074	47	47	and	and	CC
10_1101-2020_09_09_289074	47	48	6VW1	6VW1	NFP
10_1101-2020_09_09_289074	47	49	(	(	-LRB-
10_1101-2020_09_09_289074	47	50	12	12	CD
10_1101-2020_09_09_289074	47	51	)	)	-RRB-
10_1101-2020_09_09_289074	47	52	.	.	.
10_1101-2020_09_09_289074	48	1	For	for	IN
10_1101-2020_09_09_289074	48	2	6VW1	6vw1	CD
10_1101-2020_09_09_289074	48	3	,	,	,
10_1101-2020_09_09_289074	48	4	two	two	CD
10_1101-2020_09_09_289074	48	5	Spike	Spike	NNP
10_1101-2020_09_09_289074	48	6	/	/	SYM
10_1101-2020_09_09_289074	48	7	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	48	8	complexes	complex	NNS
10_1101-2020_09_09_289074	48	9	were	be	VBD
10_1101-2020_09_09_289074	48	10	available	available	JJ
10_1101-2020_09_09_289074	48	11	,	,	,
10_1101-2020_09_09_289074	48	12	so	so	RB
10_1101-2020_09_09_289074	48	13	we	-PRON-	PRP
10_1101-2020_09_09_289074	48	14	report	report	VBP
10_1101-2020_09_09_289074	48	15	results	result	NNS
10_1101-2020_09_09_289074	48	16	for	for	IN
10_1101-2020_09_09_289074	48	17	both	both	DT
10_1101-2020_09_09_289074	48	18	as	as	IN
10_1101-2020_09_09_289074	48	19	6VW1-A	6vw1-a	CD
10_1101-2020_09_09_289074	48	20	and	and	CC
10_1101-2020_09_09_289074	48	21	6WV1-B	6wv1-b	NN
10_1101-2020_09_09_289074	48	22	,	,	,
10_1101-2020_09_09_289074	48	23	separately	separately	RB
10_1101-2020_09_09_289074	48	24	.	.	.
10_1101-2020_09_09_289074	49	1	All	all	DT
10_1101-2020_09_09_289074	49	2	models	model	NNS
10_1101-2020_09_09_289074	49	3	show	show	VBP
10_1101-2020_09_09_289074	49	4	the	the	DT
10_1101-2020_09_09_289074	49	5	core	core	JJ
10_1101-2020_09_09_289074	49	6	domains	domain	NNS
10_1101-2020_09_09_289074	49	7	of	of	IN
10_1101-2020_09_09_289074	49	8	interaction	interaction	NN
10_1101-2020_09_09_289074	49	9	,	,	,
10_1101-2020_09_09_289074	49	10	located	locate	VBN
10_1101-2020_09_09_289074	49	11	in	in	IN
10_1101-2020_09_09_289074	49	12	the	the	DT
10_1101-2020_09_09_289074	49	13	region	region	NN
10_1101-2020_09_09_289074	49	14	of	of	IN
10_1101-2020_09_09_289074	49	15	AA	AA	NNP
10_1101-2020_09_09_289074	49	16	330	330	CD
10_1101-2020_09_09_289074	49	17	-	-	HYPH
10_1101-2020_09_09_289074	49	18	530	530	CD
10_1101-2020_09_09_289074	49	19	for	for	IN
10_1101-2020_09_09_289074	49	20	Spike	Spike	NNP
10_1101-2020_09_09_289074	49	21	and	and	CC
10_1101-2020_09_09_289074	49	22	in	in	IN
10_1101-2020_09_09_289074	49	23	the	the	DT
10_1101-2020_09_09_289074	49	24	region	region	NN
10_1101-2020_09_09_289074	49	25	AA	AA	NNP
10_1101-2020_09_09_289074	49	26	15	15	CD
10_1101-2020_09_09_289074	49	27	-	-	SYM
10_1101-2020_09_09_289074	49	28	615	615	CD
10_1101-2020_09_09_289074	49	29	of	of	IN
10_1101-2020_09_09_289074	49	30	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	49	31	.	.	.
10_1101-2020_09_09_289074	50	1	Full	full	JJ
10_1101-2020_09_09_289074	50	2	length	length	NN
10_1101-2020_09_09_289074	50	3	proteins	protein	NNS
10_1101-2020_09_09_289074	50	4	would	would	MD
10_1101-2020_09_09_289074	50	5	be	be	VB
10_1101-2020_09_09_289074	50	6	1273	1273	CD
10_1101-2020_09_09_289074	50	7	AAs	aa	NNS
10_1101-2020_09_09_289074	50	8	(	(	-LRB-
10_1101-2020_09_09_289074	50	9	Spike	Spike	NNP
10_1101-2020_09_09_289074	50	10	only	only	RB
10_1101-2020_09_09_289074	50	11	known	know	VBN
10_1101-2020_09_09_289074	50	12	isoform	isoform	NN
10_1101-2020_09_09_289074	50	13	,	,	,
10_1101-2020_09_09_289074	50	14	from	from	IN
10_1101-2020_09_09_289074	50	15	reference	reference	NN
10_1101-2020_09_09_289074	50	16	SARS	SARS	NNP
10_1101-2020_09_09_289074	50	17	-	-	HYPH
10_1101-2020_09_09_289074	50	18	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	50	19	genome	genome	NNP
10_1101-2020_09_09_289074	50	20	NC_045512.2	NC_045512.2	NNP
10_1101-2020_09_09_289074	50	21	)	)	-RRB-
10_1101-2020_09_09_289074	50	22	and	and	CC
10_1101-2020_09_09_289074	50	23	805	805	CD
10_1101-2020_09_09_289074	50	24	AAs	aa	NNS
10_1101-2020_09_09_289074	50	25	(	(	-LRB-
10_1101-2020_09_09_289074	50	26	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	50	27	isoform	isoform	NN
10_1101-2020_09_09_289074	50	28	1	1	CD
10_1101-2020_09_09_289074	50	29	,	,	,
10_1101-2020_09_09_289074	50	30	UniProt	UniProt	NNP
10_1101-2020_09_09_289074	50	31	i	-PRON-	PRP
10_1101-2020_09_09_289074	50	32	d	d	NN
10_1101-2020_09_09_289074	50	33	Q9BYF1	Q9BYF1	NNP
10_1101-2020_09_09_289074	50	34	-	-	HYPH
10_1101-2020_09_09_289074	50	35	1	1	CD
10_1101-2020_09_09_289074	50	36	)	)	-RRB-
10_1101-2020_09_09_289074	50	37	.	.	.
10_1101-2020_09_09_289074	51	1	Selected	select	VBN
10_1101-2020_09_09_289074	51	2	PDB	PDB	NNP
10_1101-2020_09_09_289074	51	3	entries	entry	NNS
10_1101-2020_09_09_289074	51	4	are	be	VBP
10_1101-2020_09_09_289074	51	5	wild	wild	JJ
10_1101-2020_09_09_289074	51	6	type	type	NN
10_1101-2020_09_09_289074	51	7	and	and	CC
10_1101-2020_09_09_289074	51	8	their	-PRON-	PRP$
10_1101-2020_09_09_289074	51	9	primary	primary	JJ
10_1101-2020_09_09_289074	51	10	sequence	sequence	NN
10_1101-2020_09_09_289074	51	11	and	and	CC
10_1101-2020_09_09_289074	51	12	the	the	DT
10_1101-2020_09_09_289074	51	13	higher	high	JJR
10_1101-2020_09_09_289074	51	14	order	order	NN
10_1101-2020_09_09_289074	51	15	structures	structure	NNS
10_1101-2020_09_09_289074	51	16	were	be	VBD
10_1101-2020_09_09_289074	51	17	identical	identical	JJ
10_1101-2020_09_09_289074	51	18	.	.	.
10_1101-2020_09_09_289074	52	1	Residues	Residues	NNP
10_1101-2020_09_09_289074	52	2	517	517	CD
10_1101-2020_09_09_289074	52	3	-	-	HYPH
10_1101-2020_09_09_289074	52	4	519	519	CD
10_1101-2020_09_09_289074	52	5	were	be	VBD
10_1101-2020_09_09_289074	52	6	missed	miss	VBN
10_1101-2020_09_09_289074	52	7	in	in	IN
10_1101-2020_09_09_289074	52	8	6VW1-B.	6vw1-b.	NN
10_1101-2020_09_09_289074	53	1	With	with	IN
10_1101-2020_09_09_289074	53	2	the	the	DT
10_1101-2020_09_09_289074	53	3	aim	aim	NN
10_1101-2020_09_09_289074	53	4	to	to	TO
10_1101-2020_09_09_289074	53	5	investigate	investigate	VB
10_1101-2020_09_09_289074	53	6	the	the	DT
10_1101-2020_09_09_289074	53	7	conformation	conformation	NN
10_1101-2020_09_09_289074	53	8	variability	variability	NN
10_1101-2020_09_09_289074	53	9	,	,	,
10_1101-2020_09_09_289074	53	10	PDB	PDB	NNP
10_1101-2020_09_09_289074	53	11	complexes	complex	NNS
10_1101-2020_09_09_289074	53	12	were	be	VBD
10_1101-2020_09_09_289074	53	13	aligned	align	VBN
10_1101-2020_09_09_289074	53	14	by	by	IN
10_1101-2020_09_09_289074	53	15	backbone	backbone	NN
10_1101-2020_09_09_289074	53	16	and	and	CC
10_1101-2020_09_09_289074	53	17	the	the	DT
10_1101-2020_09_09_289074	53	18	Root	Root	NNP
10_1101-2020_09_09_289074	53	19	Mean	Mean	NNP
10_1101-2020_09_09_289074	53	20	Square	Square	NNP
10_1101-2020_09_09_289074	53	21	deviation	deviation	NN
10_1101-2020_09_09_289074	53	22	(	(	-LRB-
10_1101-2020_09_09_289074	53	23	RMSd	RMSd	NNP
10_1101-2020_09_09_289074	53	24	)	)	-RRB-
10_1101-2020_09_09_289074	53	25	was	be	VBD
10_1101-2020_09_09_289074	53	26	computed	compute	VBN
10_1101-2020_09_09_289074	53	27	on	on	IN
10_1101-2020_09_09_289074	53	28	all	all	DT
10_1101-2020_09_09_289074	53	29	equivalent	equivalent	JJ
10_1101-2020_09_09_289074	53	30	not	not	RB
10_1101-2020_09_09_289074	53	31	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	53	32	atoms	atom	NNS
10_1101-2020_09_09_289074	53	33	.	.	.
10_1101-2020_09_09_289074	54	1	RMSd	RMSd	NNP
10_1101-2020_09_09_289074	54	2	data	datum	NNS
10_1101-2020_09_09_289074	54	3	have	have	VBP
10_1101-2020_09_09_289074	54	4	shown	show	VBN
10_1101-2020_09_09_289074	54	5	some	some	DT
10_1101-2020_09_09_289074	54	6	conformation	conformation	NN
10_1101-2020_09_09_289074	54	7	flexibility	flexibility	NN
10_1101-2020_09_09_289074	54	8	that	that	WDT
10_1101-2020_09_09_289074	54	9	confirmed	confirm	VBD
10_1101-2020_09_09_289074	54	10	our	-PRON-	PRP$
10_1101-2020_09_09_289074	54	11	idea	idea	NN
10_1101-2020_09_09_289074	54	12	to	to	TO
10_1101-2020_09_09_289074	54	13	take	take	VB
10_1101-2020_09_09_289074	54	14	into	into	IN
10_1101-2020_09_09_289074	54	15	account	account	NN
10_1101-2020_09_09_289074	54	16	all	all	DT
10_1101-2020_09_09_289074	54	17	PDB	PDB	NNP
10_1101-2020_09_09_289074	54	18	structures	structure	NNS
10_1101-2020_09_09_289074	54	19	in	in	IN
10_1101-2020_09_09_289074	54	20	the	the	DT
10_1101-2020_09_09_289074	54	21	next	next	JJ
10_1101-2020_09_09_289074	54	22	investigation	investigation	NN
10_1101-2020_09_09_289074	54	23	(	(	-LRB-
10_1101-2020_09_09_289074	54	24	Fig	fig	NN
10_1101-2020_09_09_289074	54	25	1	1	CD
10_1101-2020_09_09_289074	54	26	)	)	-RRB-
10_1101-2020_09_09_289074	54	27	.	.	.
10_1101-2020_09_09_289074	55	1	The	the	DT
10_1101-2020_09_09_289074	55	2	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	55	3	method	method	NN
10_1101-2020_09_09_289074	55	4	was	be	VBD
10_1101-2020_09_09_289074	55	5	originally	originally	RB
10_1101-2020_09_09_289074	55	6	developed	develop	VBN
10_1101-2020_09_09_289074	55	7	for	for	IN
10_1101-2020_09_09_289074	55	8	identifying	identify	VBG
10_1101-2020_09_09_289074	55	9	and	and	CC
10_1101-2020_09_09_289074	55	10	scoring	score	VBG
10_1101-2020_09_09_289074	55	11	pharmacophore	pharmacophore	NN
10_1101-2020_09_09_289074	55	12	and	and	CC
10_1101-2020_09_09_289074	55	13	protein-	protein-	VBG
10_1101-2020_09_09_289074	55	14	protein	protein	NN
10_1101-2020_09_09_289074	55	15	interaction	interaction	NN
10_1101-2020_09_09_289074	55	16	key	key	JJ
10_1101-2020_09_09_289074	55	17	features	feature	NNS
10_1101-2020_09_09_289074	55	18	by	by	IN
10_1101-2020_09_09_289074	55	19	combining	combine	VBG
10_1101-2020_09_09_289074	55	20	GRID	GRID	NNP
10_1101-2020_09_09_289074	55	21	molecular	molecular	JJ
10_1101-2020_09_09_289074	55	22	interaction	interaction	NN
10_1101-2020_09_09_289074	55	23	fields	field	NNS
10_1101-2020_09_09_289074	55	24	(	(	-LRB-
10_1101-2020_09_09_289074	55	25	MIFs	MIFs	NNP
10_1101-2020_09_09_289074	55	26	)	)	-RRB-
10_1101-2020_09_09_289074	55	27	according	accord	VBG
10_1101-2020_09_09_289074	55	28	to	to	IN
10_1101-2020_09_09_289074	55	29	the	the	DT
10_1101-2020_09_09_289074	55	30	GRAB	GRAB	NNP
10_1101-2020_09_09_289074	55	31	tool	tool	NN
10_1101-2020_09_09_289074	55	32	algorithm	algorithm	NNP
10_1101-2020_09_09_289074	55	33	(	(	-LRB-
10_1101-2020_09_09_289074	55	34	28	28	CD
10_1101-2020_09_09_289074	55	35	)	)	-RRB-
10_1101-2020_09_09_289074	55	36	.	.	.
10_1101-2020_09_09_289074	56	1	In	in	IN
10_1101-2020_09_09_289074	56	2	the	the	DT
10_1101-2020_09_09_289074	56	3	present	present	JJ
10_1101-2020_09_09_289074	56	4	study	study	NN
10_1101-2020_09_09_289074	56	5	,	,	,
10_1101-2020_09_09_289074	56	6	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	56	7	has	have	VBZ
10_1101-2020_09_09_289074	56	8	been	be	VBN
10_1101-2020_09_09_289074	56	9	applied	apply	VBN
10_1101-2020_09_09_289074	56	10	to	to	IN
10_1101-2020_09_09_289074	56	11	all	all	DT
10_1101-2020_09_09_289074	56	12	selected	select	VBN
10_1101-2020_09_09_289074	56	13	complex	complex	JJ
10_1101-2020_09_09_289074	56	14	models	model	NNS
10_1101-2020_09_09_289074	56	15	considering	consider	VBG
10_1101-2020_09_09_289074	56	16	Spike	Spike	NNP
10_1101-2020_09_09_289074	56	17	and	and	CC
10_1101-2020_09_09_289074	56	18	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	56	19	either	either	RB
10_1101-2020_09_09_289074	56	20	as	as	IN
10_1101-2020_09_09_289074	56	21	host	host	NN
10_1101-2020_09_09_289074	56	22	or	or	CC
10_1101-2020_09_09_289074	56	23	guest	guest	NN
10_1101-2020_09_09_289074	56	24	.	.	.
10_1101-2020_09_09_289074	57	1	DRY	DRY	NNP
10_1101-2020_09_09_289074	57	2	,	,	,
10_1101-2020_09_09_289074	57	3	N1	n1	NN
10_1101-2020_09_09_289074	57	4	and	and	CC
10_1101-2020_09_09_289074	57	5	O	o	UH
10_1101-2020_09_09_289074	57	6	GRID	GRID	NNP
10_1101-2020_09_09_289074	57	7	probes	probe	NNS
10_1101-2020_09_09_289074	57	8	were	be	VBD
10_1101-2020_09_09_289074	57	9	considered	consider	VBN
10_1101-2020_09_09_289074	57	10	for	for	IN
10_1101-2020_09_09_289074	57	11	describing	describe	VBG
10_1101-2020_09_09_289074	57	12	hydrophobic	hydrophobic	NN
10_1101-2020_09_09_289074	57	13	,	,	,
10_1101-2020_09_09_289074	57	14	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	57	15	bond	bond	NN
10_1101-2020_09_09_289074	57	16	donor	donor	NN
10_1101-2020_09_09_289074	57	17	and	and	CC
10_1101-2020_09_09_289074	57	18	hydrogen	hydrogen	NNP
10_1101-2020_09_09_289074	57	19	bond	bond	NNP
10_1101-2020_09_09_289074	57	20	acceptor	acceptor	NN
10_1101-2020_09_09_289074	57	21	interaction	interaction	NNP
10_1101-2020_09_09_289074	57	22	.	.	.
10_1101-2020_09_09_289074	58	1	For	for	IN
10_1101-2020_09_09_289074	58	2	each	each	DT
10_1101-2020_09_09_289074	58	3	probe	probe	NN
10_1101-2020_09_09_289074	58	4	a	a	DT
10_1101-2020_09_09_289074	58	5	cut	cut	NN
10_1101-2020_09_09_289074	58	6	-	-	HYPH
10_1101-2020_09_09_289074	58	7	off	off	RP
10_1101-2020_09_09_289074	58	8	,	,	,
10_1101-2020_09_09_289074	58	9	required	require	VBN
10_1101-2020_09_09_289074	58	10	for	for	IN
10_1101-2020_09_09_289074	58	11	highlighting	highlight	VBG
10_1101-2020_09_09_289074	58	12	the	the	DT
10_1101-2020_09_09_289074	58	13	most	most	RBS
10_1101-2020_09_09_289074	58	14	relevant	relevant	JJ
10_1101-2020_09_09_289074	58	15	MIFs	MIFs	NNP
10_1101-2020_09_09_289074	58	16	points	point	NNS
10_1101-2020_09_09_289074	58	17	,	,	,
10_1101-2020_09_09_289074	58	18	was	be	VBD
10_1101-2020_09_09_289074	58	19	fixed	fix	VBN
10_1101-2020_09_09_289074	58	20	above	above	IN
10_1101-2020_09_09_289074	58	21	the	the	DT
10_1101-2020_09_09_289074	58	22	30	30	CD
10_1101-2020_09_09_289074	58	23	%	%	NN
10_1101-2020_09_09_289074	58	24	from	from	IN
10_1101-2020_09_09_289074	58	25	the	the	DT
10_1101-2020_09_09_289074	58	26	corresponding	correspond	VBG
10_1101-2020_09_09_289074	58	27	global	global	JJ
10_1101-2020_09_09_289074	58	28	minimum	minimum	JJ
10_1101-2020_09_09_289074	58	29	interaction	interaction	NN
10_1101-2020_09_09_289074	58	30	energy	energy	NN
10_1101-2020_09_09_289074	58	31	value	value	NN
10_1101-2020_09_09_289074	58	32	.	.	.
10_1101-2020_09_09_289074	59	1	With	with	IN
10_1101-2020_09_09_289074	59	2	respect	respect	NN
10_1101-2020_09_09_289074	59	3	to	to	IN
10_1101-2020_09_09_289074	59	4	the	the	DT
10_1101-2020_09_09_289074	59	5	known	know	VBN
10_1101-2020_09_09_289074	59	6	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	59	7	application	application	NN
10_1101-2020_09_09_289074	59	8	,	,	,
10_1101-2020_09_09_289074	59	9	where	where	WRB
10_1101-2020_09_09_289074	59	10	pharmacophore	pharmacophore	NN
10_1101-2020_09_09_289074	59	11	features	feature	NNS
10_1101-2020_09_09_289074	59	12	are	be	VBP
10_1101-2020_09_09_289074	59	13	used	use	VBN
10_1101-2020_09_09_289074	59	14	for	for	IN
10_1101-2020_09_09_289074	59	15	virtual	virtual	JJ
10_1101-2020_09_09_289074	59	16	screening	screening	NN
10_1101-2020_09_09_289074	59	17	.CC	.CC	NFP
10_1101-2020_09_09_289074	59	18	-	-	:
10_1101-2020_09_09_289074	59	19	BY	by	IN
10_1101-2020_09_09_289074	59	20	-	-	HYPH
10_1101-2020_09_09_289074	59	21	NC	NC	NNP
10_1101-2020_09_09_289074	59	22	-	-	HYPH
10_1101-2020_09_09_289074	59	23	ND	ND	NNP
10_1101-2020_09_09_289074	59	24	4.0	4.0	CD
10_1101-2020_09_09_289074	59	25	International	International	NNP
10_1101-2020_09_09_289074	59	26	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	59	27	under	under	IN
10_1101-2020_09_09_289074	59	28	a	a	DT
10_1101-2020_09_09_289074	59	29	(	(	-LRB-
10_1101-2020_09_09_289074	59	30	which	which	WDT
10_1101-2020_09_09_289074	59	31	was	be	VBD
10_1101-2020_09_09_289074	59	32	not	not	RB
10_1101-2020_09_09_289074	59	33	certified	certify	VBN
10_1101-2020_09_09_289074	59	34	by	by	IN
10_1101-2020_09_09_289074	59	35	peer	peer	NN
10_1101-2020_09_09_289074	59	36	review	review	NN
10_1101-2020_09_09_289074	59	37	)	)	-RRB-
10_1101-2020_09_09_289074	59	38	is	be	VBZ
10_1101-2020_09_09_289074	59	39	the	the	DT
10_1101-2020_09_09_289074	59	40	author	author	NN
10_1101-2020_09_09_289074	59	41	/	/	SYM
10_1101-2020_09_09_289074	59	42	funder	funder	NN
10_1101-2020_09_09_289074	59	43	,	,	,
10_1101-2020_09_09_289074	59	44	who	who	WP
10_1101-2020_09_09_289074	59	45	has	have	VBZ
10_1101-2020_09_09_289074	59	46	granted	grant	VBN
10_1101-2020_09_09_289074	59	47	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	59	48	a	a	DT
10_1101-2020_09_09_289074	59	49	license	license	NN
10_1101-2020_09_09_289074	59	50	to	to	TO
10_1101-2020_09_09_289074	59	51	display	display	VB
10_1101-2020_09_09_289074	59	52	the	the	DT
10_1101-2020_09_09_289074	59	53	preprint	preprint	NN
10_1101-2020_09_09_289074	59	54	in	in	IN
10_1101-2020_09_09_289074	59	55	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	59	56	.	.	.
10_1101-2020_09_09_289074	60	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	60	2	is	be	VBZ
10_1101-2020_09_09_289074	60	3	made	make	VBN
10_1101-2020_09_09_289074	60	4	The	the	DT
10_1101-2020_09_09_289074	60	5	copyright	copyright	NN
10_1101-2020_09_09_289074	60	6	holder	holder	NN
10_1101-2020_09_09_289074	60	7	for	for	IN
10_1101-2020_09_09_289074	60	8	this	this	DT
10_1101-2020_09_09_289074	60	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	60	10	version	version	NN
10_1101-2020_09_09_289074	60	11	posted	post	VBD
10_1101-2020_09_09_289074	60	12	January	January	NNP
10_1101-2020_09_09_289074	60	13	5	5	CD
10_1101-2020_09_09_289074	60	14	,	,	,
10_1101-2020_09_09_289074	60	15	2021	2021	CD
10_1101-2020_09_09_289074	60	16	.	.	.
10_1101-2020_09_09_289074	60	17	;	;	:
10_1101-2020_09_09_289074	60	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	60	19	:	:	:
10_1101-2020_09_09_289074	60	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	60	21	preprint	preprint	NN
10_1101-2020_09_09_289074	60	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	60	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	60	24	5	5	CD
10_1101-2020_09_09_289074	60	25	purposes	purpose	NNS
10_1101-2020_09_09_289074	60	26	,	,	,
10_1101-2020_09_09_289074	60	27	here	here	RB
10_1101-2020_09_09_289074	60	28	these	these	DT
10_1101-2020_09_09_289074	60	29	data	datum	NNS
10_1101-2020_09_09_289074	60	30	guided	guide	VBD
10_1101-2020_09_09_289074	60	31	us	-PRON-	PRP
10_1101-2020_09_09_289074	60	32	in	in	IN
10_1101-2020_09_09_289074	60	33	the	the	DT
10_1101-2020_09_09_289074	60	34	complex	complex	JJ
10_1101-2020_09_09_289074	60	35	stabilizing	stabilize	VBG
10_1101-2020_09_09_289074	60	36	AAs	AAs	NNP
10_1101-2020_09_09_289074	60	37	identification	identification	NN
10_1101-2020_09_09_289074	60	38	.	.	.
10_1101-2020_09_09_289074	61	1	In	in	IN
10_1101-2020_09_09_289074	61	2	fact	fact	NN
10_1101-2020_09_09_289074	61	3	,	,	,
10_1101-2020_09_09_289074	61	4	Spike	Spike	NNP
10_1101-2020_09_09_289074	61	5	or	or	CC
10_1101-2020_09_09_289074	61	6	ACE-2	ACE-2	NNP
10_1101-2020_09_09_289074	61	7	residues	residue	NNS
10_1101-2020_09_09_289074	61	8	,	,	,
10_1101-2020_09_09_289074	61	9	within	within	IN
10_1101-2020_09_09_289074	61	10	3	3	CD
10_1101-2020_09_09_289074	61	11	Å	Å	NNP
10_1101-2020_09_09_289074	61	12	from	from	IN
10_1101-2020_09_09_289074	61	13	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	61	14	points	point	NNS
10_1101-2020_09_09_289074	61	15	,	,	,
10_1101-2020_09_09_289074	61	16	were	be	VBD
10_1101-2020_09_09_289074	61	17	marked	mark	VBN
10_1101-2020_09_09_289074	61	18	as	as	IN
10_1101-2020_09_09_289074	61	19	relevant	relevant	JJ
10_1101-2020_09_09_289074	61	20	in	in	IN
10_1101-2020_09_09_289074	61	21	the	the	DT
10_1101-2020_09_09_289074	61	22	host	host	NN
10_1101-2020_09_09_289074	61	23	-	-	HYPH
10_1101-2020_09_09_289074	61	24	guest	guest	JJ
10_1101-2020_09_09_289074	61	25	recognition	recognition	NN
10_1101-2020_09_09_289074	61	26	and	and	CC
10_1101-2020_09_09_289074	61	27	were	be	VBD
10_1101-2020_09_09_289074	61	28	qualitatively	qualitatively	RB
10_1101-2020_09_09_289074	61	29	scored	score	VBN
10_1101-2020_09_09_289074	61	30	by	by	IN
10_1101-2020_09_09_289074	61	31	assigning	assign	VBG
10_1101-2020_09_09_289074	61	32	them	-PRON-	PRP
10_1101-2020_09_09_289074	61	33	the	the	DT
10_1101-2020_09_09_289074	61	34	corresponding	correspond	VBG
10_1101-2020_09_09_289074	61	35	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	61	36	energy	energy	NN
10_1101-2020_09_09_289074	61	37	.	.	.
10_1101-2020_09_09_289074	62	1	If	if	IN
10_1101-2020_09_09_289074	62	2	a	a	DT
10_1101-2020_09_09_289074	62	3	certain	certain	JJ
10_1101-2020_09_09_289074	62	4	residue	residue	NN
10_1101-2020_09_09_289074	62	5	was	be	VBD
10_1101-2020_09_09_289074	62	6	suggested	suggest	VBN
10_1101-2020_09_09_289074	62	7	by	by	IN
10_1101-2020_09_09_289074	62	8	more	more	JJR
10_1101-2020_09_09_289074	62	9	than	than	IN
10_1101-2020_09_09_289074	62	10	one	one	CD
10_1101-2020_09_09_289074	62	11	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	62	12	point	point	NN
10_1101-2020_09_09_289074	62	13	,	,	,
10_1101-2020_09_09_289074	62	14	its	-PRON-	PRP$
10_1101-2020_09_09_289074	62	15	score	score	NN
10_1101-2020_09_09_289074	62	16	was	be	VBD
10_1101-2020_09_09_289074	62	17	computed	compute	VBN
10_1101-2020_09_09_289074	62	18	as	as	IN
10_1101-2020_09_09_289074	62	19	summa	summa	JJR
10_1101-2020_09_09_289074	62	20	of	of	IN
10_1101-2020_09_09_289074	62	21	the	the	DT
10_1101-2020_09_09_289074	62	22	related	related	JJ
10_1101-2020_09_09_289074	62	23	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	62	24	points	point	NNS
10_1101-2020_09_09_289074	62	25	energy	energy	NN
10_1101-2020_09_09_289074	62	26	(	(	-LRB-
10_1101-2020_09_09_289074	62	27	Fig	fig	NN
10_1101-2020_09_09_289074	62	28	.	.	.
10_1101-2020_09_09_289074	63	1	2	2	LS
10_1101-2020_09_09_289074	63	2	)	)	-RRB-
10_1101-2020_09_09_289074	63	3	.	.	.
10_1101-2020_09_09_289074	64	1	Finally	finally	RB
10_1101-2020_09_09_289074	64	2	,	,	,
10_1101-2020_09_09_289074	64	3	for	for	IN
10_1101-2020_09_09_289074	64	4	each	each	DT
10_1101-2020_09_09_289074	64	5	selected	select	VBN
10_1101-2020_09_09_289074	64	6	residue	residue	NN
10_1101-2020_09_09_289074	64	7	,	,	,
10_1101-2020_09_09_289074	64	8	the	the	DT
10_1101-2020_09_09_289074	64	9	four	four	CD
10_1101-2020_09_09_289074	64	10	models	model	NNS
10_1101-2020_09_09_289074	64	11	averaged	average	VBN
10_1101-2020_09_09_289074	64	12	score	score	NN
10_1101-2020_09_09_289074	64	13	was	be	VBD
10_1101-2020_09_09_289074	64	14	considered	consider	VBN
10_1101-2020_09_09_289074	64	15	for	for	IN
10_1101-2020_09_09_289074	64	16	estimating	estimate	VBG
10_1101-2020_09_09_289074	64	17	the	the	DT
10_1101-2020_09_09_289074	64	18	role	role	NN
10_1101-2020_09_09_289074	64	19	in	in	IN
10_1101-2020_09_09_289074	64	20	complex	complex	JJ
10_1101-2020_09_09_289074	64	21	stabilization	stabilization	NN
10_1101-2020_09_09_289074	64	22	.	.	.
10_1101-2020_09_09_289074	65	1	Taking	take	VBG
10_1101-2020_09_09_289074	65	2	into	into	IN
10_1101-2020_09_09_289074	65	3	account	account	NN
10_1101-2020_09_09_289074	65	4	their	-PRON-	PRP$
10_1101-2020_09_09_289074	65	5	average	average	JJ
10_1101-2020_09_09_289074	65	6	scores	score	NNS
10_1101-2020_09_09_289074	65	7	,	,	,
10_1101-2020_09_09_289074	65	8	Spike	Spike	NNP
10_1101-2020_09_09_289074	65	9	and	and	CC
10_1101-2020_09_09_289074	65	10	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	65	11	AAs	aa	NNS
10_1101-2020_09_09_289074	65	12	were	be	VBD
10_1101-2020_09_09_289074	65	13	divided	divide	VBN
10_1101-2020_09_09_289074	65	14	by	by	IN
10_1101-2020_09_09_289074	65	15	quartiles	quartile	NNS
10_1101-2020_09_09_289074	65	16	to	to	TO
10_1101-2020_09_09_289074	65	17	facilitate	facilitate	VB
10_1101-2020_09_09_289074	65	18	the	the	DT
10_1101-2020_09_09_289074	65	19	interpretation	interpretation	NN
10_1101-2020_09_09_289074	65	20	of	of	IN
10_1101-2020_09_09_289074	65	21	the	the	DT
10_1101-2020_09_09_289074	65	22	results	result	NNS
10_1101-2020_09_09_289074	65	23	:	:	:
10_1101-2020_09_09_289074	65	24	quartile	quartile	NNP
10_1101-2020_09_09_289074	65	25	1	1	CD
10_1101-2020_09_09_289074	65	26	(	(	-LRB-
10_1101-2020_09_09_289074	65	27	Q1	Q1	NNP
10_1101-2020_09_09_289074	65	28	)	)	-RRB-
10_1101-2020_09_09_289074	65	29	includes	include	VBZ
10_1101-2020_09_09_289074	65	30	the	the	DT
10_1101-2020_09_09_289074	65	31	strongest	strong	JJS
10_1101-2020_09_09_289074	65	32	complex	complex	JJ
10_1101-2020_09_09_289074	65	33	stabilization	stabilization	NN
10_1101-2020_09_09_289074	65	34	contributors	contributor	NNS
10_1101-2020_09_09_289074	65	35	;	;	:
10_1101-2020_09_09_289074	65	36	quartile	quartile	NNP
10_1101-2020_09_09_289074	65	37	2	2	CD
10_1101-2020_09_09_289074	65	38	(	(	-LRB-
10_1101-2020_09_09_289074	65	39	Q2	q2	NN
10_1101-2020_09_09_289074	65	40	)	)	-RRB-
10_1101-2020_09_09_289074	65	41	contains	contain	VBZ
10_1101-2020_09_09_289074	65	42	residues	residue	NNS
10_1101-2020_09_09_289074	65	43	less	less	RBR
10_1101-2020_09_09_289074	65	44	important	important	JJ
10_1101-2020_09_09_289074	65	45	than	than	IN
10_1101-2020_09_09_289074	65	46	those	those	DT
10_1101-2020_09_09_289074	65	47	reported	report	VBN
10_1101-2020_09_09_289074	65	48	in	in	IN
10_1101-2020_09_09_289074	65	49	Q1	Q1	NNP
10_1101-2020_09_09_289074	65	50	but	but	CC
10_1101-2020_09_09_289074	65	51	most	most	RBS
10_1101-2020_09_09_289074	65	52	relevant	relevant	JJ
10_1101-2020_09_09_289074	65	53	of	of	IN
10_1101-2020_09_09_289074	65	54	those	those	DT
10_1101-2020_09_09_289074	65	55	included	include	VBN
10_1101-2020_09_09_289074	65	56	in	in	IN
10_1101-2020_09_09_289074	65	57	quartile	quartile	NNP
10_1101-2020_09_09_289074	65	58	3	3	CD
10_1101-2020_09_09_289074	65	59	(	(	-LRB-
10_1101-2020_09_09_289074	65	60	Q3	Q3	NNP
10_1101-2020_09_09_289074	65	61	)	)	-RRB-
10_1101-2020_09_09_289074	65	62	;	;	:
10_1101-2020_09_09_289074	65	63	quartile	quartile	NNP
10_1101-2020_09_09_289074	65	64	4	4	CD
10_1101-2020_09_09_289074	65	65	(	(	-LRB-
10_1101-2020_09_09_289074	65	66	Q4	Q4	NNP
10_1101-2020_09_09_289074	65	67	)	)	-RRB-
10_1101-2020_09_09_289074	65	68	indicates	indicate	VBZ
10_1101-2020_09_09_289074	65	69	the	the	DT
10_1101-2020_09_09_289074	65	70	weakest	weak	JJS
10_1101-2020_09_09_289074	65	71	predicted	predict	VBN
10_1101-2020_09_09_289074	65	72	interacting	interact	VBG
10_1101-2020_09_09_289074	65	73	AAs	AAs	NNP
10_1101-2020_09_09_289074	65	74	.	.	.
10_1101-2020_09_09_289074	66	1	Such	such	PDT
10_1101-2020_09_09_289074	66	2	an	an	DT
10_1101-2020_09_09_289074	66	3	extension	extension	NN
10_1101-2020_09_09_289074	66	4	of	of	IN
10_1101-2020_09_09_289074	66	5	the	the	DT
10_1101-2020_09_09_289074	66	6	original	original	JJ
10_1101-2020_09_09_289074	66	7	approach	approach	NN
10_1101-2020_09_09_289074	66	8	allowed	allow	VBD
10_1101-2020_09_09_289074	66	9	us	-PRON-	PRP
10_1101-2020_09_09_289074	66	10	to	to	TO
10_1101-2020_09_09_289074	66	11	highlight	highlight	VB
10_1101-2020_09_09_289074	66	12	known	know	VBN
10_1101-2020_09_09_289074	66	13	relevant	relevant	JJ
10_1101-2020_09_09_289074	66	14	interaction	interaction	NN
10_1101-2020_09_09_289074	66	15	residues	residue	NNS
10_1101-2020_09_09_289074	66	16	of	of	IN
10_1101-2020_09_09_289074	66	17	both	both	DT
10_1101-2020_09_09_289074	66	18	Spike	Spike	NNP
10_1101-2020_09_09_289074	66	19	(	(	-LRB-
10_1101-2020_09_09_289074	66	20	Table	table	NN
10_1101-2020_09_09_289074	66	21	1	1	CD
10_1101-2020_09_09_289074	66	22	)	)	-RRB-
10_1101-2020_09_09_289074	66	23	and	and	CC
10_1101-2020_09_09_289074	66	24	ACE-2	ACE-2	NNP
10_1101-2020_09_09_289074	66	25	(	(	-LRB-
10_1101-2020_09_09_289074	66	26	Table	table	NN
10_1101-2020_09_09_289074	66	27	2	2	CD
10_1101-2020_09_09_289074	66	28	)	)	-RRB-
10_1101-2020_09_09_289074	66	29	.	.	.
10_1101-2020_09_09_289074	67	1	Basically	basically	RB
10_1101-2020_09_09_289074	67	2	,	,	,
10_1101-2020_09_09_289074	67	3	the	the	DT
10_1101-2020_09_09_289074	67	4	same	same	JJ
10_1101-2020_09_09_289074	67	5	number	number	NN
10_1101-2020_09_09_289074	67	6	of	of	IN
10_1101-2020_09_09_289074	67	7	AAs	AAs	NNP
10_1101-2020_09_09_289074	67	8	was	be	VBD
10_1101-2020_09_09_289074	67	9	highlighted	highlight	VBN
10_1101-2020_09_09_289074	67	10	for	for	IN
10_1101-2020_09_09_289074	67	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	67	12	(	(	-LRB-
10_1101-2020_09_09_289074	67	13	26	26	CD
10_1101-2020_09_09_289074	67	14	AAs	aa	NNS
10_1101-2020_09_09_289074	67	15	)	)	-RRB-
10_1101-2020_09_09_289074	67	16	and	and	CC
10_1101-2020_09_09_289074	67	17	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	67	18	(	(	-LRB-
10_1101-2020_09_09_289074	67	19	25	25	CD
10_1101-2020_09_09_289074	67	20	AAs	aa	NNS
10_1101-2020_09_09_289074	67	21	)	)	-RRB-
10_1101-2020_09_09_289074	67	22	.	.	.
10_1101-2020_09_09_289074	68	1	The	the	DT
10_1101-2020_09_09_289074	68	2	average	average	JJ
10_1101-2020_09_09_289074	68	3	score	score	NN
10_1101-2020_09_09_289074	68	4	was	be	VBD
10_1101-2020_09_09_289074	68	5	also	also	RB
10_1101-2020_09_09_289074	68	6	in	in	IN
10_1101-2020_09_09_289074	68	7	the	the	DT
10_1101-2020_09_09_289074	68	8	same	same	JJ
10_1101-2020_09_09_289074	68	9	range	range	NN
10_1101-2020_09_09_289074	68	10	.	.	.
10_1101-2020_09_09_289074	69	1	Spike	Spike	NNP
10_1101-2020_09_09_289074	69	2	reported	report	VBD
10_1101-2020_09_09_289074	69	3	a	a	DT
10_1101-2020_09_09_289074	69	4	population	population	NN
10_1101-2020_09_09_289074	69	5	of	of	IN
10_1101-2020_09_09_289074	69	6	Q1	Q1	NNP
10_1101-2020_09_09_289074	69	7	larger	large	JJR
10_1101-2020_09_09_289074	69	8	than	than	IN
10_1101-2020_09_09_289074	69	9	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	69	10	:	:	:
10_1101-2020_09_09_289074	69	11	12	12	CD
10_1101-2020_09_09_289074	69	12	and	and	CC
10_1101-2020_09_09_289074	69	13	7	7	CD
10_1101-2020_09_09_289074	69	14	AAs	aa	NNS
10_1101-2020_09_09_289074	69	15	,	,	,
10_1101-2020_09_09_289074	69	16	respectively	respectively	RB
10_1101-2020_09_09_289074	69	17	.	.	.
10_1101-2020_09_09_289074	70	1	The	the	DT
10_1101-2020_09_09_289074	70	2	opposite	opposite	JJ
10_1101-2020_09_09_289074	70	3	scenario	scenario	NN
10_1101-2020_09_09_289074	70	4	was	be	VBD
10_1101-2020_09_09_289074	70	5	observed	observe	VBN
10_1101-2020_09_09_289074	70	6	in	in	IN
10_1101-2020_09_09_289074	70	7	the	the	DT
10_1101-2020_09_09_289074	70	8	Q2	q2	NN
10_1101-2020_09_09_289074	70	9	that	that	WDT
10_1101-2020_09_09_289074	70	10	accounted	account	VBD
10_1101-2020_09_09_289074	70	11	for	for	IN
10_1101-2020_09_09_289074	70	12	7	7	CD
10_1101-2020_09_09_289074	70	13	residues	residue	NNS
10_1101-2020_09_09_289074	70	14	for	for	IN
10_1101-2020_09_09_289074	70	15	Spike	Spike	NNP
10_1101-2020_09_09_289074	70	16	and	and	CC
10_1101-2020_09_09_289074	70	17	11	11	CD
10_1101-2020_09_09_289074	70	18	for	for	IN
10_1101-2020_09_09_289074	70	19	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	70	20	.	.	.
10_1101-2020_09_09_289074	71	1	No	no	DT
10_1101-2020_09_09_289074	71	2	remarkable	remarkable	JJ
10_1101-2020_09_09_289074	71	3	difference	difference	NN
10_1101-2020_09_09_289074	71	4	can	can	MD
10_1101-2020_09_09_289074	71	5	be	be	VB
10_1101-2020_09_09_289074	71	6	addressed	address	VBN
10_1101-2020_09_09_289074	71	7	to	to	IN
10_1101-2020_09_09_289074	71	8	the	the	DT
10_1101-2020_09_09_289074	71	9	Q3	Q3	NNP
10_1101-2020_09_09_289074	71	10	and	and	CC
10_1101-2020_09_09_289074	71	11	Q4	Q4	NNP
10_1101-2020_09_09_289074	71	12	Spike	Spike	NNP
10_1101-2020_09_09_289074	71	13	-	-	HYPH
10_1101-2020_09_09_289074	71	14	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	71	15	comparison	comparison	NN
10_1101-2020_09_09_289074	71	16	.	.	.
10_1101-2020_09_09_289074	72	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	72	2	reasoned	reason	VBD
10_1101-2020_09_09_289074	72	3	that	that	IN
10_1101-2020_09_09_289074	72	4	mutations	mutation	NNS
10_1101-2020_09_09_289074	72	5	and	and	CC
10_1101-2020_09_09_289074	72	6	variants	variant	NNS
10_1101-2020_09_09_289074	72	7	in	in	IN
10_1101-2020_09_09_289074	72	8	Q1	Q1	NNP
10_1101-2020_09_09_289074	72	9	residues	residue	NNS
10_1101-2020_09_09_289074	72	10	could	could	MD
10_1101-2020_09_09_289074	72	11	have	have	VB
10_1101-2020_09_09_289074	72	12	a	a	DT
10_1101-2020_09_09_289074	72	13	more	more	RBR
10_1101-2020_09_09_289074	72	14	relevant	relevant	JJ
10_1101-2020_09_09_289074	72	15	impact	impact	NN
10_1101-2020_09_09_289074	72	16	in	in	IN
10_1101-2020_09_09_289074	72	17	the	the	DT
10_1101-2020_09_09_289074	72	18	complex	complex	JJ
10_1101-2020_09_09_289074	72	19	stability	stability	NN
10_1101-2020_09_09_289074	72	20	.	.	.
10_1101-2020_09_09_289074	73	1	The	the	DT
10_1101-2020_09_09_289074	73	2	analysis	analysis	NN
10_1101-2020_09_09_289074	73	3	of	of	IN
10_1101-2020_09_09_289074	73	4	all	all	DT
10_1101-2020_09_09_289074	73	5	designed	design	VBN
10_1101-2020_09_09_289074	73	6	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	73	7	suggested	suggest	VBD
10_1101-2020_09_09_289074	73	8	the	the	DT
10_1101-2020_09_09_289074	73	9	Spike	Spike	NNP
10_1101-2020_09_09_289074	73	10	-	-	HYPH
10_1101-2020_09_09_289074	73	11	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	73	12	molecular	molecular	JJ
10_1101-2020_09_09_289074	73	13	recognition	recognition	NN
10_1101-2020_09_09_289074	73	14	is	be	VBZ
10_1101-2020_09_09_289074	73	15	largely	largely	RB
10_1101-2020_09_09_289074	73	16	sustained	sustain	VBN
10_1101-2020_09_09_289074	73	17	by	by	IN
10_1101-2020_09_09_289074	73	18	polar	polar	JJ
10_1101-2020_09_09_289074	73	19	interactions	interaction	NNS
10_1101-2020_09_09_289074	73	20	,	,	,
10_1101-2020_09_09_289074	73	21	such	such	JJ
10_1101-2020_09_09_289074	73	22	as	as	IN
10_1101-2020_09_09_289074	73	23	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	73	24	bonds	bond	NNS
10_1101-2020_09_09_289074	73	25	,	,	,
10_1101-2020_09_09_289074	73	26	and	and	CC
10_1101-2020_09_09_289074	73	27	by	by	IN
10_1101-2020_09_09_289074	73	28	very	very	RB
10_1101-2020_09_09_289074	73	29	few	few	JJ
10_1101-2020_09_09_289074	73	30	putative	putative	JJ
10_1101-2020_09_09_289074	73	31	hydrophobic	hydrophobic	NN
10_1101-2020_09_09_289074	73	32	contributions	contribution	NNS
10_1101-2020_09_09_289074	73	33	(	(	-LRB-
10_1101-2020_09_09_289074	73	34	Table	table	NN
10_1101-2020_09_09_289074	73	35	3	3	CD
10_1101-2020_09_09_289074	73	36	)	)	-RRB-
10_1101-2020_09_09_289074	73	37	.	.	.
10_1101-2020_09_09_289074	74	1	Mutational	mutational	JJ
10_1101-2020_09_09_289074	74	2	analysis	analysis	NN
10_1101-2020_09_09_289074	74	3	of	of	IN
10_1101-2020_09_09_289074	74	4	SARS	SARS	NNP
10_1101-2020_09_09_289074	74	5	-	-	HYPH
10_1101-2020_09_09_289074	74	6	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	74	7	Spike	Spike	NNP
10_1101-2020_09_09_289074	74	8	We	-PRON-	PRP
10_1101-2020_09_09_289074	74	9	analyzed	analyze	VBD
10_1101-2020_09_09_289074	74	10	295,507	295,507	CD
10_1101-2020_09_09_289074	74	11	publicly	publicly	RB
10_1101-2020_09_09_289074	74	12	available	available	JJ
10_1101-2020_09_09_289074	74	13	SARS	SARS	NNP
10_1101-2020_09_09_289074	74	14	-	-	HYPH
10_1101-2020_09_09_289074	74	15	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	74	16	full	full	JJ
10_1101-2020_09_09_289074	74	17	-	-	HYPH
10_1101-2020_09_09_289074	74	18	length	length	NN
10_1101-2020_09_09_289074	74	19	genome	genome	JJ
10_1101-2020_09_09_289074	74	20	sequences	sequence	NNS
10_1101-2020_09_09_289074	74	21	collected	collect	VBN
10_1101-2020_09_09_289074	74	22	worldwide	worldwide	RB
10_1101-2020_09_09_289074	74	23	and	and	CC
10_1101-2020_09_09_289074	74	24	deposited	deposit	VBN
10_1101-2020_09_09_289074	74	25	on	on	IN
10_1101-2020_09_09_289074	74	26	the	the	DT
10_1101-2020_09_09_289074	74	27	GISAID	GISAID	NNP
10_1101-2020_09_09_289074	74	28	database	database	NN
10_1101-2020_09_09_289074	74	29	on	on	IN
10_1101-2020_09_09_289074	74	30	December	December	NNP
10_1101-2020_09_09_289074	74	31	30	30	CD
10_1101-2020_09_09_289074	74	32	,	,	,
10_1101-2020_09_09_289074	74	33	2020	2020	CD
10_1101-2020_09_09_289074	74	34	(	(	-LRB-
10_1101-2020_09_09_289074	74	35	29	29	CD
10_1101-2020_09_09_289074	74	36	)	)	-RRB-
10_1101-2020_09_09_289074	74	37	.	.	.
10_1101-2020_09_09_289074	75	1	From	from	IN
10_1101-2020_09_09_289074	75	2	these	these	DT
10_1101-2020_09_09_289074	75	3	,	,	,
10_1101-2020_09_09_289074	75	4	we	-PRON-	PRP
10_1101-2020_09_09_289074	75	5	obtained	obtain	VBD
10_1101-2020_09_09_289074	75	6	257,434	257,434	CD
10_1101-2020_09_09_289074	75	7	samples	sample	NNS
10_1101-2020_09_09_289074	75	8	containing	contain	VBG
10_1101-2020_09_09_289074	75	9	at	at	RB
10_1101-2020_09_09_289074	75	10	least	least	RBS
10_1101-2020_09_09_289074	75	11	one	one	CD
10_1101-2020_09_09_289074	75	12	AA	aa	NN
10_1101-2020_09_09_289074	75	13	-	-	HYPH
10_1101-2020_09_09_289074	75	14	changing	change	VBG
10_1101-2020_09_09_289074	75	15	mutation	mutation	NN
10_1101-2020_09_09_289074	75	16	in	in	IN
10_1101-2020_09_09_289074	75	17	the	the	DT
10_1101-2020_09_09_289074	75	18	Spike	Spike	NNP
10_1101-2020_09_09_289074	75	19	protein	protein	NN
10_1101-2020_09_09_289074	75	20	.	.	.
10_1101-2020_09_09_289074	76	1	A	a	DT
10_1101-2020_09_09_289074	76	2	total	total	NN
10_1101-2020_09_09_289074	76	3	of	of	IN
10_1101-2020_09_09_289074	76	4	3,314	3,314	CD
10_1101-2020_09_09_289074	76	5	different	different	JJ
10_1101-2020_09_09_289074	76	6	AA	AA	NNP
10_1101-2020_09_09_289074	76	7	-	-	HYPH
10_1101-2020_09_09_289074	76	8	changing	change	VBG
10_1101-2020_09_09_289074	76	9	mutations	mutation	NNS
10_1101-2020_09_09_289074	76	10	were	be	VBD
10_1101-2020_09_09_289074	76	11	detected	detect	VBN
10_1101-2020_09_09_289074	76	12	in	in	IN
10_1101-2020_09_09_289074	76	13	the	the	DT
10_1101-2020_09_09_289074	76	14	1,279	1,279	CD
10_1101-2020_09_09_289074	76	15	AA	AA	NNP
10_1101-2020_09_09_289074	76	16	-	-	HYPH
10_1101-2020_09_09_289074	76	17	long	long	JJ
10_1101-2020_09_09_289074	76	18	Spike	Spike	NNP
10_1101-2020_09_09_289074	76	19	sequence	sequence	NN
10_1101-2020_09_09_289074	76	20	.	.	.
10_1101-2020_09_09_289074	77	1	However	however	RB
10_1101-2020_09_09_289074	77	2	,	,	,
10_1101-2020_09_09_289074	77	3	many	many	JJ
10_1101-2020_09_09_289074	77	4	of	of	IN
10_1101-2020_09_09_289074	77	5	these	these	DT
10_1101-2020_09_09_289074	77	6	are	be	VBP
10_1101-2020_09_09_289074	77	7	unique	unique	JJ
10_1101-2020_09_09_289074	77	8	events	event	NNS
10_1101-2020_09_09_289074	77	9	(	(	-LRB-
10_1101-2020_09_09_289074	77	10	or	or	CC
10_1101-2020_09_09_289074	77	11	possibly	possibly	RB
10_1101-2020_09_09_289074	77	12	even	even	RB
10_1101-2020_09_09_289074	77	13	sequencing	sequence	VBG
10_1101-2020_09_09_289074	77	14	errors	error	NNS
10_1101-2020_09_09_289074	77	15	)	)	-RRB-
10_1101-2020_09_09_289074	77	16	,	,	,
10_1101-2020_09_09_289074	77	17	as	as	IN
10_1101-2020_09_09_289074	77	18	only	only	RB
10_1101-2020_09_09_289074	77	19	2,023	2,023	CD
10_1101-2020_09_09_289074	77	20	mutations	mutation	NNS
10_1101-2020_09_09_289074	77	21	were	be	VBD
10_1101-2020_09_09_289074	77	22	found	find	VBN
10_1101-2020_09_09_289074	77	23	in	in	IN
10_1101-2020_09_09_289074	77	24	more	more	JJR
10_1101-2020_09_09_289074	77	25	than	than	IN
10_1101-2020_09_09_289074	77	26	one	one	CD
10_1101-2020_09_09_289074	77	27	sample	sample	NN
10_1101-2020_09_09_289074	77	28	,	,	,
10_1101-2020_09_09_289074	77	29	788	788	CD
10_1101-2020_09_09_289074	77	30	were	be	VBD
10_1101-2020_09_09_289074	77	31	found	find	VBN
10_1101-2020_09_09_289074	77	32	in	in	IN
10_1101-2020_09_09_289074	77	33	more	more	JJR
10_1101-2020_09_09_289074	77	34	than	than	IN
10_1101-2020_09_09_289074	77	35	ten	ten	CD
10_1101-2020_09_09_289074	77	36	samples	sample	NNS
10_1101-2020_09_09_289074	77	37	,	,	,
10_1101-2020_09_09_289074	77	38	and	and	CC
10_1101-2020_09_09_289074	77	39	196	196	CD
10_1101-2020_09_09_289074	77	40	in	in	IN
10_1101-2020_09_09_289074	77	41	more	more	JJR
10_1101-2020_09_09_289074	77	42	than	than	IN
10_1101-2020_09_09_289074	77	43	one	one	CD
10_1101-2020_09_09_289074	77	44	hundred	hundred	CD
10_1101-2020_09_09_289074	77	45	samples	sample	NNS
10_1101-2020_09_09_289074	77	46	(	(	-LRB-
10_1101-2020_09_09_289074	77	47	Supplementary	Supplementary	NNP
10_1101-2020_09_09_289074	77	48	File	File	NNP
10_1101-2020_09_09_289074	77	49	1	1	CD
10_1101-2020_09_09_289074	77	50	)	)	-RRB-
10_1101-2020_09_09_289074	77	51	.	.	.
10_1101-2020_09_09_289074	78	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	78	2	then	then	RB
10_1101-2020_09_09_289074	78	3	focused	focus	VBD
10_1101-2020_09_09_289074	78	4	on	on	IN
10_1101-2020_09_09_289074	78	5	mutations	mutation	NNS
10_1101-2020_09_09_289074	78	6	located	locate	VBN
10_1101-2020_09_09_289074	78	7	in	in	IN
10_1101-2020_09_09_289074	78	8	the	the	DT
10_1101-2020_09_09_289074	78	9	Spike	Spike	NNP
10_1101-2020_09_09_289074	78	10	RBD	RBD	NNP
10_1101-2020_09_09_289074	78	11	(	(	-LRB-
10_1101-2020_09_09_289074	78	12	aa	aa	NNP
10_1101-2020_09_09_289074	78	13	330	330	CD
10_1101-2020_09_09_289074	78	14	-	-	SYM
10_1101-2020_09_09_289074	78	15	530	530	CD
10_1101-2020_09_09_289074	78	16	)	)	-RRB-
10_1101-2020_09_09_289074	78	17	with	with	IN
10_1101-2020_09_09_289074	78	18	predicted	predict	VBN
10_1101-2020_09_09_289074	78	19	interaction	interaction	NN
10_1101-2020_09_09_289074	78	20	contribution	contribution	NN
10_1101-2020_09_09_289074	78	21	,	,	,
10_1101-2020_09_09_289074	78	22	as	as	IN
10_1101-2020_09_09_289074	78	23	assessed	assess	VBN
10_1101-2020_09_09_289074	78	24	by	by	IN
10_1101-2020_09_09_289074	78	25	our	-PRON-	PRP$
10_1101-2020_09_09_289074	78	26	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	78	27	method	method	NN
10_1101-2020_09_09_289074	78	28	.	.	.
10_1101-2020_09_09_289074	79	1	The	the	DT
10_1101-2020_09_09_289074	79	2	majority	majority	NN
10_1101-2020_09_09_289074	79	3	of	of	IN
10_1101-2020_09_09_289074	79	4	mutations	mutation	NNS
10_1101-2020_09_09_289074	79	5	here	here	RB
10_1101-2020_09_09_289074	79	6	are	be	VBP
10_1101-2020_09_09_289074	79	7	found	find	VBN
10_1101-2020_09_09_289074	79	8	in	in	IN
10_1101-2020_09_09_289074	79	9	only	only	RB
10_1101-2020_09_09_289074	79	10	a	a	DT
10_1101-2020_09_09_289074	79	11	handful	handful	NN
10_1101-2020_09_09_289074	79	12	of	of	IN
10_1101-2020_09_09_289074	79	13	samples	sample	NNS
10_1101-2020_09_09_289074	79	14	(	(	-LRB-
10_1101-2020_09_09_289074	79	15	Table	table	NN
10_1101-2020_09_09_289074	79	16	4	4	CD
10_1101-2020_09_09_289074	79	17	and	and	CC
10_1101-2020_09_09_289074	79	18	Fig	fig	NN
10_1101-2020_09_09_289074	79	19	4	4	CD
10_1101-2020_09_09_289074	79	20	A	a	NN
10_1101-2020_09_09_289074	79	21	)	)	-RRB-
10_1101-2020_09_09_289074	79	22	,	,	,
10_1101-2020_09_09_289074	79	23	with	with	IN
10_1101-2020_09_09_289074	79	24	a	a	DT
10_1101-2020_09_09_289074	79	25	few	few	JJ
10_1101-2020_09_09_289074	79	26	notable	notable	JJ
10_1101-2020_09_09_289074	79	27	exceptions	exception	NNS
10_1101-2020_09_09_289074	79	28	.	.	.
10_1101-2020_09_09_289074	80	1	The	the	DT
10_1101-2020_09_09_289074	80	2	mutations	mutation	NNS
10_1101-2020_09_09_289074	80	3	S477N	S477N	NNP
10_1101-2020_09_09_289074	80	4	and	and	CC
10_1101-2020_09_09_289074	80	5	N439	N439	NNP
10_1101-2020_09_09_289074	80	6	K	K	NNP
10_1101-2020_09_09_289074	80	7	are	be	VBP
10_1101-2020_09_09_289074	80	8	the	the	DT
10_1101-2020_09_09_289074	80	9	most	most	RBS
10_1101-2020_09_09_289074	80	10	frequent	frequent	JJ
10_1101-2020_09_09_289074	80	11	in	in	IN
10_1101-2020_09_09_289074	80	12	the	the	DT
10_1101-2020_09_09_289074	80	13	current	current	JJ
10_1101-2020_09_09_289074	80	14	population	population	NN
10_1101-2020_09_09_289074	80	15	and	and	CC
10_1101-2020_09_09_289074	80	16	were	be	VBD
10_1101-2020_09_09_289074	80	17	identified	identify	VBN
10_1101-2020_09_09_289074	80	18	in	in	IN
10_1101-2020_09_09_289074	80	19	16,547	16,547	CD
10_1101-2020_09_09_289074	80	20	patients	patient	NNS
10_1101-2020_09_09_289074	80	21	(	(	-LRB-
10_1101-2020_09_09_289074	80	22	5.60	5.60	CD
10_1101-2020_09_09_289074	80	23	%	%	NN
10_1101-2020_09_09_289074	80	24	)	)	-RRB-
10_1101-2020_09_09_289074	80	25	and	and	CC
10_1101-2020_09_09_289074	80	26	5,587	5,587	CD
10_1101-2020_09_09_289074	80	27	patients	patient	NNS
10_1101-2020_09_09_289074	80	28	(	(	-LRB-
10_1101-2020_09_09_289074	80	29	1.89	1.89	CD
10_1101-2020_09_09_289074	80	30	%	%	NN
10_1101-2020_09_09_289074	80	31	)	)	-RRB-
10_1101-2020_09_09_289074	80	32	respectively	respectively	RB
10_1101-2020_09_09_289074	80	33	.	.	.
10_1101-2020_09_09_289074	81	1	These	these	DT
10_1101-2020_09_09_289074	81	2	two	two	CD
10_1101-2020_09_09_289074	81	3	variants	variant	NNS
10_1101-2020_09_09_289074	81	4	(	(	-LRB-
10_1101-2020_09_09_289074	81	5	N439	N439	NNP
10_1101-2020_09_09_289074	81	6	K	K	NNP
10_1101-2020_09_09_289074	81	7	and	and	CC
10_1101-2020_09_09_289074	81	8	S477N	S477N	NNP
10_1101-2020_09_09_289074	81	9	)	)	-RRB-
10_1101-2020_09_09_289074	81	10	are	be	VBP
10_1101-2020_09_09_289074	81	11	also	also	RB
10_1101-2020_09_09_289074	81	12	amongst	amongst	IN
10_1101-2020_09_09_289074	81	13	the	the	DT
10_1101-2020_09_09_289074	81	14	top	top	JJ
10_1101-2020_09_09_289074	81	15	20	20	CD
10_1101-2020_09_09_289074	81	16	most	most	RBS
10_1101-2020_09_09_289074	81	17	frequent	frequent	JJ
10_1101-2020_09_09_289074	81	18	in	in	IN
10_1101-2020_09_09_289074	81	19	the	the	DT
10_1101-2020_09_09_289074	81	20	population	population	NN
10_1101-2020_09_09_289074	81	21	and	and	CC
10_1101-2020_09_09_289074	81	22	involve	involve	VBP
10_1101-2020_09_09_289074	81	23	two	two	CD
10_1101-2020_09_09_289074	81	24	positions	position	NNS
10_1101-2020_09_09_289074	81	25	productively	productively	RB
10_1101-2020_09_09_289074	81	26	contributing	contribute	VBG
10_1101-2020_09_09_289074	81	27	to	to	IN
10_1101-2020_09_09_289074	81	28	the	the	DT
10_1101-2020_09_09_289074	81	29	interaction	interaction	NN
10_1101-2020_09_09_289074	81	30	between	between	IN
10_1101-2020_09_09_289074	81	31	Spike	Spike	NNP
10_1101-2020_09_09_289074	81	32	and	and	CC
10_1101-2020_09_09_289074	81	33	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	81	34	,	,	,
10_1101-2020_09_09_289074	81	35	according	accord	VBG
10_1101-2020_09_09_289074	81	36	to	to	IN
10_1101-2020_09_09_289074	81	37	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	81	38	(	(	-LRB-
10_1101-2020_09_09_289074	81	39	see	see	VB
10_1101-2020_09_09_289074	81	40	Table	table	NN
10_1101-2020_09_09_289074	81	41	1	1	CD
10_1101-2020_09_09_289074	81	42	and	and	CC
10_1101-2020_09_09_289074	81	43	Fig	fig	NN
10_1101-2020_09_09_289074	81	44	3	3	CD
10_1101-2020_09_09_289074	81	45	for	for	IN
10_1101-2020_09_09_289074	81	46	locations	location	NNS
10_1101-2020_09_09_289074	81	47	439	439	CD
10_1101-2020_09_09_289074	81	48	and	and	CC
10_1101-2020_09_09_289074	81	49	477	477	CD
10_1101-2020_09_09_289074	81	50	)	)	-RRB-
10_1101-2020_09_09_289074	81	51	.	.	.
10_1101-2020_09_09_289074	82	1	The	the	DT
10_1101-2020_09_09_289074	82	2	graphical	graphical	JJ
10_1101-2020_09_09_289074	82	3	inspection	inspection	NN
10_1101-2020_09_09_289074	82	4	of	of	IN
10_1101-2020_09_09_289074	82	5	the	the	DT
10_1101-2020_09_09_289074	82	6	PDB	PDB	NNP
10_1101-2020_09_09_289074	82	7	structures	structure	NNS
10_1101-2020_09_09_289074	82	8	revealed	reveal	VBD
10_1101-2020_09_09_289074	82	9	that	that	IN
10_1101-2020_09_09_289074	82	10	Spike	Spike	NNP
10_1101-2020_09_09_289074	82	11	Asparagine	Asparagine	NNP
10_1101-2020_09_09_289074	82	12	(	(	-LRB-
10_1101-2020_09_09_289074	82	13	N	n	NN
10_1101-2020_09_09_289074	82	14	)	)	-RRB-
10_1101-2020_09_09_289074	82	15	439	439	CD
10_1101-2020_09_09_289074	82	16	,	,	,
10_1101-2020_09_09_289074	82	17	raked	rake	VBN
10_1101-2020_09_09_289074	82	18	at	at	IN
10_1101-2020_09_09_289074	82	19	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	82	20	Q2	Q2	NNP
10_1101-2020_09_09_289074	82	21	,	,	,
10_1101-2020_09_09_289074	82	22	is	be	VBZ
10_1101-2020_09_09_289074	82	23	mainly	mainly	RB
10_1101-2020_09_09_289074	82	24	involved	involve	VBN
10_1101-2020_09_09_289074	82	25	in	in	IN
10_1101-2020_09_09_289074	82	26	intra	intra	JJ
10_1101-2020_09_09_289074	82	27	-	-	JJ
10_1101-2020_09_09_289074	82	28	protein	protein	JJ
10_1101-2020_09_09_289074	82	29	interaction	interaction	NN
10_1101-2020_09_09_289074	82	30	.	.	.
10_1101-2020_09_09_289074	83	1	In	in	IN
10_1101-2020_09_09_289074	83	2	fact	fact	NN
10_1101-2020_09_09_289074	83	3	,	,	,
10_1101-2020_09_09_289074	83	4	by	by	IN
10_1101-2020_09_09_289074	83	5	means	mean	NNS
10_1101-2020_09_09_289074	83	6	of	of	IN
10_1101-2020_09_09_289074	83	7	its	-PRON-	PRP$
10_1101-2020_09_09_289074	83	8	backbone	backbone	NN
10_1101-2020_09_09_289074	83	9	sp2	sp2	NNP
10_1101-2020_09_09_289074	83	10	oxygen	oxygen	NNP
10_1101-2020_09_09_289074	83	11	atom	atom	NNP
10_1101-2020_09_09_289074	83	12	,	,	,
10_1101-2020_09_09_289074	83	13	N439	N439	NNP
10_1101-2020_09_09_289074	83	14	accepts	accept	VBZ
10_1101-2020_09_09_289074	83	15	one	one	CD
10_1101-2020_09_09_289074	83	16	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	83	17	bond	bond	NN
10_1101-2020_09_09_289074	83	18	from	from	IN
10_1101-2020_09_09_289074	83	19	Spike	Spike	NNP
10_1101-2020_09_09_289074	83	20	Serine	Serine	NNP
10_1101-2020_09_09_289074	83	21	443	443	CD
10_1101-2020_09_09_289074	83	22	sidechain	sidechain	NN
10_1101-2020_09_09_289074	83	23	and	and	CC
10_1101-2020_09_09_289074	83	24	,	,	,
10_1101-2020_09_09_289074	83	25	by	by	IN
10_1101-2020_09_09_289074	83	26	its	-PRON-	PRP$
10_1101-2020_09_09_289074	83	27	sidechain	sidechain	JJ
10_1101-2020_09_09_289074	83	28	amide	amide	NN
10_1101-2020_09_09_289074	83	29	.CC	.CC	NFP
10_1101-2020_09_09_289074	83	30	-	-	:
10_1101-2020_09_09_289074	83	31	BY	by	IN
10_1101-2020_09_09_289074	83	32	-	-	HYPH
10_1101-2020_09_09_289074	83	33	NC	NC	NNP
10_1101-2020_09_09_289074	83	34	-	-	HYPH
10_1101-2020_09_09_289074	83	35	ND	ND	NNP
10_1101-2020_09_09_289074	83	36	4.0	4.0	CD
10_1101-2020_09_09_289074	83	37	International	International	NNP
10_1101-2020_09_09_289074	83	38	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	83	39	under	under	IN
10_1101-2020_09_09_289074	83	40	a	a	DT
10_1101-2020_09_09_289074	83	41	(	(	-LRB-
10_1101-2020_09_09_289074	83	42	which	which	WDT
10_1101-2020_09_09_289074	83	43	was	be	VBD
10_1101-2020_09_09_289074	83	44	not	not	RB
10_1101-2020_09_09_289074	83	45	certified	certify	VBN
10_1101-2020_09_09_289074	83	46	by	by	IN
10_1101-2020_09_09_289074	83	47	peer	peer	NN
10_1101-2020_09_09_289074	83	48	review	review	NN
10_1101-2020_09_09_289074	83	49	)	)	-RRB-
10_1101-2020_09_09_289074	83	50	is	be	VBZ
10_1101-2020_09_09_289074	83	51	the	the	DT
10_1101-2020_09_09_289074	83	52	author	author	NN
10_1101-2020_09_09_289074	83	53	/	/	SYM
10_1101-2020_09_09_289074	83	54	funder	funder	NN
10_1101-2020_09_09_289074	83	55	,	,	,
10_1101-2020_09_09_289074	83	56	who	who	WP
10_1101-2020_09_09_289074	83	57	has	have	VBZ
10_1101-2020_09_09_289074	83	58	granted	grant	VBN
10_1101-2020_09_09_289074	83	59	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	83	60	a	a	DT
10_1101-2020_09_09_289074	83	61	license	license	NN
10_1101-2020_09_09_289074	83	62	to	to	TO
10_1101-2020_09_09_289074	83	63	display	display	VB
10_1101-2020_09_09_289074	83	64	the	the	DT
10_1101-2020_09_09_289074	83	65	preprint	preprint	NN
10_1101-2020_09_09_289074	83	66	in	in	IN
10_1101-2020_09_09_289074	83	67	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	83	68	.	.	.
10_1101-2020_09_09_289074	84	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	84	2	is	be	VBZ
10_1101-2020_09_09_289074	84	3	made	make	VBN
10_1101-2020_09_09_289074	84	4	The	the	DT
10_1101-2020_09_09_289074	84	5	copyright	copyright	NN
10_1101-2020_09_09_289074	84	6	holder	holder	NN
10_1101-2020_09_09_289074	84	7	for	for	IN
10_1101-2020_09_09_289074	84	8	this	this	DT
10_1101-2020_09_09_289074	84	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	84	10	version	version	NN
10_1101-2020_09_09_289074	84	11	posted	post	VBD
10_1101-2020_09_09_289074	84	12	January	January	NNP
10_1101-2020_09_09_289074	84	13	5	5	CD
10_1101-2020_09_09_289074	84	14	,	,	,
10_1101-2020_09_09_289074	84	15	2021	2021	CD
10_1101-2020_09_09_289074	84	16	.	.	.
10_1101-2020_09_09_289074	84	17	;	;	:
10_1101-2020_09_09_289074	84	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	84	19	:	:	:
10_1101-2020_09_09_289074	84	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	84	21	preprint	preprint	NN
10_1101-2020_09_09_289074	84	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	84	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NNP
10_1101-2020_09_09_289074	84	24	6	6	CD
10_1101-2020_09_09_289074	84	25	group	group	NN
10_1101-2020_09_09_289074	84	26	,	,	,
10_1101-2020_09_09_289074	84	27	donates	donate	VBZ
10_1101-2020_09_09_289074	84	28	one	one	CD
10_1101-2020_09_09_289074	84	29	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	84	30	bond	bond	NN
10_1101-2020_09_09_289074	84	31	to	to	IN
10_1101-2020_09_09_289074	84	32	the	the	DT
10_1101-2020_09_09_289074	84	33	Spike	Spike	NNP
10_1101-2020_09_09_289074	84	34	Proline	Proline	NNP
10_1101-2020_09_09_289074	84	35	499	499	CD
10_1101-2020_09_09_289074	84	36	backbone	backbone	NN
10_1101-2020_09_09_289074	84	37	:	:	:
10_1101-2020_09_09_289074	84	38	all	all	PDT
10_1101-2020_09_09_289074	84	39	these	these	DT
10_1101-2020_09_09_289074	84	40	AAs	aa	NNS
10_1101-2020_09_09_289074	84	41	are	be	VBP
10_1101-2020_09_09_289074	84	42	located	locate	VBN
10_1101-2020_09_09_289074	84	43	into	into	IN
10_1101-2020_09_09_289074	84	44	a	a	DT
10_1101-2020_09_09_289074	84	45	random	random	JJ
10_1101-2020_09_09_289074	84	46	coil	coil	NN
10_1101-2020_09_09_289074	84	47	loop	loop	NN
10_1101-2020_09_09_289074	84	48	of	of	IN
10_1101-2020_09_09_289074	84	49	Spike	Spike	NNP
10_1101-2020_09_09_289074	84	50	so	so	IN
10_1101-2020_09_09_289074	84	51	the	the	DT
10_1101-2020_09_09_289074	84	52	N439	N439	NNP
10_1101-2020_09_09_289074	84	53	K	k	NN
10_1101-2020_09_09_289074	84	54	could	could	MD
10_1101-2020_09_09_289074	84	55	minimally	minimally	RB
10_1101-2020_09_09_289074	84	56	modify	modify	VB
10_1101-2020_09_09_289074	84	57	the	the	DT
10_1101-2020_09_09_289074	84	58	Spike	Spike	NNP
10_1101-2020_09_09_289074	84	59	-	-	HYPH
10_1101-2020_09_09_289074	84	60	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	84	61	recognition	recognition	NN
10_1101-2020_09_09_289074	84	62	.	.	.
10_1101-2020_09_09_289074	85	1	On	on	IN
10_1101-2020_09_09_289074	85	2	the	the	DT
10_1101-2020_09_09_289074	85	3	other	other	JJ
10_1101-2020_09_09_289074	85	4	hand	hand	NN
10_1101-2020_09_09_289074	85	5	,	,	,
10_1101-2020_09_09_289074	85	6	after	after	IN
10_1101-2020_09_09_289074	85	7	the	the	DT
10_1101-2020_09_09_289074	85	8	theoretical	theoretical	JJ
10_1101-2020_09_09_289074	85	9	mutation	mutation	NN
10_1101-2020_09_09_289074	85	10	of	of	IN
10_1101-2020_09_09_289074	85	11	the	the	DT
10_1101-2020_09_09_289074	85	12	Asparagine	Asparagine	NNP
10_1101-2020_09_09_289074	85	13	439	439	CD
10_1101-2020_09_09_289074	85	14	with	with	IN
10_1101-2020_09_09_289074	85	15	a	a	DT
10_1101-2020_09_09_289074	85	16	Lysine	Lysine	NNP
10_1101-2020_09_09_289074	85	17	,	,	,
10_1101-2020_09_09_289074	85	18	it	-PRON-	PRP
10_1101-2020_09_09_289074	85	19	is	be	VBZ
10_1101-2020_09_09_289074	85	20	possible	possible	JJ
10_1101-2020_09_09_289074	85	21	to	to	TO
10_1101-2020_09_09_289074	85	22	predict	predict	VB
10_1101-2020_09_09_289074	85	23	a	a	DT
10_1101-2020_09_09_289074	85	24	productive	productive	JJ
10_1101-2020_09_09_289074	85	25	electrostatic	electrostatic	JJ
10_1101-2020_09_09_289074	85	26	interaction	interaction	NN
10_1101-2020_09_09_289074	85	27	between	between	IN
10_1101-2020_09_09_289074	85	28	the	the	DT
10_1101-2020_09_09_289074	85	29	new	new	JJ
10_1101-2020_09_09_289074	85	30	net	net	NN
10_1101-2020_09_09_289074	85	31	positively	positively	RB
10_1101-2020_09_09_289074	85	32	charged	charge	VBN
10_1101-2020_09_09_289074	85	33	residue	residue	NN
10_1101-2020_09_09_289074	85	34	and	and	CC
10_1101-2020_09_09_289074	85	35	the	the	DT
10_1101-2020_09_09_289074	85	36	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	85	37	Glutamate	Glutamate	NNP
10_1101-2020_09_09_289074	85	38	329	329	CD
10_1101-2020_09_09_289074	85	39	.	.	.
10_1101-2020_09_09_289074	86	1	Such	such	PDT
10_1101-2020_09_09_289074	86	2	a	a	DT
10_1101-2020_09_09_289074	86	3	long	long	JJ
10_1101-2020_09_09_289074	86	4	-	-	HYPH
10_1101-2020_09_09_289074	86	5	distance	distance	NN
10_1101-2020_09_09_289074	86	6	interaction	interaction	NN
10_1101-2020_09_09_289074	86	7	could	could	MD
10_1101-2020_09_09_289074	86	8	improve	improve	VB
10_1101-2020_09_09_289074	86	9	the	the	DT
10_1101-2020_09_09_289074	86	10	stabilization	stabilization	NN
10_1101-2020_09_09_289074	86	11	of	of	IN
10_1101-2020_09_09_289074	86	12	the	the	DT
10_1101-2020_09_09_289074	86	13	complex	complex	NN
10_1101-2020_09_09_289074	86	14	with	with	IN
10_1101-2020_09_09_289074	86	15	respect	respect	NN
10_1101-2020_09_09_289074	86	16	to	to	IN
10_1101-2020_09_09_289074	86	17	the	the	DT
10_1101-2020_09_09_289074	86	18	Spike	spike	JJ
10_1101-2020_09_09_289074	86	19	wild	wild	JJ
10_1101-2020_09_09_289074	86	20	type	type	NN
10_1101-2020_09_09_289074	86	21	(	(	-LRB-
10_1101-2020_09_09_289074	86	22	Figure	figure	NN
10_1101-2020_09_09_289074	86	23	S1	s1	NN
10_1101-2020_09_09_289074	86	24	)	)	-RRB-
10_1101-2020_09_09_289074	86	25	.	.	.
10_1101-2020_09_09_289074	87	1	A	a	DT
10_1101-2020_09_09_289074	87	2	similar	similar	JJ
10_1101-2020_09_09_289074	87	3	effect	effect	NN
10_1101-2020_09_09_289074	87	4	could	could	MD
10_1101-2020_09_09_289074	87	5	be	be	VB
10_1101-2020_09_09_289074	87	6	addressed	address	VBN
10_1101-2020_09_09_289074	87	7	to	to	IN
10_1101-2020_09_09_289074	87	8	the	the	DT
10_1101-2020_09_09_289074	87	9	mutation	mutation	NN
10_1101-2020_09_09_289074	87	10	at	at	IN
10_1101-2020_09_09_289074	87	11	position	position	NN
10_1101-2020_09_09_289074	87	12	477	477	CD
10_1101-2020_09_09_289074	87	13	.	.	.
10_1101-2020_09_09_289074	88	1	Serine	Serine	NNP
10_1101-2020_09_09_289074	88	2	(	(	-LRB-
10_1101-2020_09_09_289074	88	3	S	S	NNP
10_1101-2020_09_09_289074	88	4	)	)	-RRB-
10_1101-2020_09_09_289074	88	5	477	477	CD
10_1101-2020_09_09_289074	88	6	is	be	VBZ
10_1101-2020_09_09_289074	88	7	a	a	DT
10_1101-2020_09_09_289074	88	8	weak	weak	JJ
10_1101-2020_09_09_289074	88	9	contributor	contributor	NN
10_1101-2020_09_09_289074	88	10	to	to	IN
10_1101-2020_09_09_289074	88	11	the	the	DT
10_1101-2020_09_09_289074	88	12	complex	complex	JJ
10_1101-2020_09_09_289074	88	13	interaction	interaction	NN
10_1101-2020_09_09_289074	88	14	.	.	.
10_1101-2020_09_09_289074	89	1	In	in	IN
10_1101-2020_09_09_289074	89	2	all	all	DT
10_1101-2020_09_09_289074	89	3	PDB	PDB	NNP
10_1101-2020_09_09_289074	89	4	entries	entry	NNS
10_1101-2020_09_09_289074	89	5	we	-PRON-	PRP
10_1101-2020_09_09_289074	89	6	selected	select	VBD
10_1101-2020_09_09_289074	89	7	,	,	,
10_1101-2020_09_09_289074	89	8	Serine	Serine	NNP
10_1101-2020_09_09_289074	89	9	477	477	CD
10_1101-2020_09_09_289074	89	10	is	be	VBZ
10_1101-2020_09_09_289074	89	11	located	locate	VBN
10_1101-2020_09_09_289074	89	12	into	into	IN
10_1101-2020_09_09_289074	89	13	a	a	DT
10_1101-2020_09_09_289074	89	14	solvent	solvent	NN
10_1101-2020_09_09_289074	89	15	exposed	expose	VBN
10_1101-2020_09_09_289074	89	16	random	random	JJ
10_1101-2020_09_09_289074	89	17	coil	coil	NNP
10_1101-2020_09_09_289074	89	18	loop	loop	NN
10_1101-2020_09_09_289074	89	19	.	.	.
10_1101-2020_09_09_289074	90	1	No	no	DT
10_1101-2020_09_09_289074	90	2	interaction	interaction	NN
10_1101-2020_09_09_289074	90	3	with	with	IN
10_1101-2020_09_09_289074	90	4	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	90	5	or	or	CC
10_1101-2020_09_09_289074	90	6	Spike	Spike	NNP
10_1101-2020_09_09_289074	90	7	residues	residue	NNS
10_1101-2020_09_09_289074	90	8	can	can	MD
10_1101-2020_09_09_289074	90	9	be	be	VB
10_1101-2020_09_09_289074	90	10	observed	observe	VBN
10_1101-2020_09_09_289074	90	11	.	.	.
10_1101-2020_09_09_289074	91	1	Actually	actually	RB
10_1101-2020_09_09_289074	91	2	,	,	,
10_1101-2020_09_09_289074	91	3	the	the	DT
10_1101-2020_09_09_289074	91	4	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	91	5	analysis	analysis	NN
10_1101-2020_09_09_289074	91	6	included	include	VBD
10_1101-2020_09_09_289074	91	7	such	such	PDT
10_1101-2020_09_09_289074	91	8	a	a	DT
10_1101-2020_09_09_289074	91	9	residue	residue	NN
10_1101-2020_09_09_289074	91	10	in	in	IN
10_1101-2020_09_09_289074	91	11	Q2	q2	NN
10_1101-2020_09_09_289074	91	12	.	.	.
10_1101-2020_09_09_289074	92	1	Conversely	conversely	RB
10_1101-2020_09_09_289074	92	2	,	,	,
10_1101-2020_09_09_289074	92	3	its	-PRON-	PRP$
10_1101-2020_09_09_289074	92	4	mutation	mutation	NN
10_1101-2020_09_09_289074	92	5	to	to	IN
10_1101-2020_09_09_289074	92	6	Asparagine	Asparagine	NNP
10_1101-2020_09_09_289074	92	7	(	(	-LRB-
10_1101-2020_09_09_289074	92	8	S477N	S477N	NNP
10_1101-2020_09_09_289074	92	9	)	)	-RRB-
10_1101-2020_09_09_289074	92	10	,	,	,
10_1101-2020_09_09_289074	92	11	in	in	IN
10_1101-2020_09_09_289074	92	12	our	-PRON-	PRP$
10_1101-2020_09_09_289074	92	13	in	in	IN
10_1101-2020_09_09_289074	92	14	silico	silico	NNP
10_1101-2020_09_09_289074	92	15	model	model	NN
10_1101-2020_09_09_289074	92	16	,	,	,
10_1101-2020_09_09_289074	92	17	revealed	reveal	VBD
10_1101-2020_09_09_289074	92	18	the	the	DT
10_1101-2020_09_09_289074	92	19	possibility	possibility	NN
10_1101-2020_09_09_289074	92	20	to	to	TO
10_1101-2020_09_09_289074	92	21	establish	establish	VB
10_1101-2020_09_09_289074	92	22	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	92	23	bond	bond	NN
10_1101-2020_09_09_289074	92	24	to	to	IN
10_1101-2020_09_09_289074	92	25	the	the	DT
10_1101-2020_09_09_289074	92	26	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	92	27	Serine	Serine	NNP
10_1101-2020_09_09_289074	92	28	19	19	CD
10_1101-2020_09_09_289074	92	29	that	that	WDT
10_1101-2020_09_09_289074	92	30	can	can	MD
10_1101-2020_09_09_289074	92	31	clearly	clearly	RB
10_1101-2020_09_09_289074	92	32	result	result	VB
10_1101-2020_09_09_289074	92	33	in	in	IN
10_1101-2020_09_09_289074	92	34	a	a	DT
10_1101-2020_09_09_289074	92	35	stabilization	stabilization	NN
10_1101-2020_09_09_289074	92	36	of	of	IN
10_1101-2020_09_09_289074	92	37	the	the	DT
10_1101-2020_09_09_289074	92	38	complex	complex	JJ
10_1101-2020_09_09_289074	92	39	(	(	-LRB-
10_1101-2020_09_09_289074	92	40	Figure	Figure	NNP
10_1101-2020_09_09_289074	92	41	S2	S2	NNP
10_1101-2020_09_09_289074	92	42	)	)	-RRB-
10_1101-2020_09_09_289074	92	43	.	.	.
10_1101-2020_09_09_289074	93	1	Moreover	moreover	RB
10_1101-2020_09_09_289074	93	2	,	,	,
10_1101-2020_09_09_289074	93	3	position	position	NN
10_1101-2020_09_09_289074	93	4	477	477	CD
10_1101-2020_09_09_289074	93	5	is	be	VBZ
10_1101-2020_09_09_289074	93	6	also	also	RB
10_1101-2020_09_09_289074	93	7	affected	affect	VBN
10_1101-2020_09_09_289074	93	8	by	by	IN
10_1101-2020_09_09_289074	93	9	three	three	CD
10_1101-2020_09_09_289074	93	10	other	other	JJ
10_1101-2020_09_09_289074	93	11	events	event	NNS
10_1101-2020_09_09_289074	93	12	with	with	IN
10_1101-2020_09_09_289074	93	13	lower	low	JJR
10_1101-2020_09_09_289074	93	14	occurrence	occurrence	NN
10_1101-2020_09_09_289074	93	15	:	:	:
10_1101-2020_09_09_289074	93	16	S477I	S477I	NNP
10_1101-2020_09_09_289074	93	17	,	,	,
10_1101-2020_09_09_289074	93	18	S477R	S477R	NNP
10_1101-2020_09_09_289074	93	19	and	and	CC
10_1101-2020_09_09_289074	93	20	S477	S477	NNP
10_1101-2020_09_09_289074	93	21	G	G	NNP
10_1101-2020_09_09_289074	93	22	,	,	,
10_1101-2020_09_09_289074	93	23	with	with	IN
10_1101-2020_09_09_289074	93	24	6	6	CD
10_1101-2020_09_09_289074	93	25	,	,	,
10_1101-2020_09_09_289074	93	26	2	2	CD
10_1101-2020_09_09_289074	93	27	and	and	CC
10_1101-2020_09_09_289074	93	28	2	2	CD
10_1101-2020_09_09_289074	93	29	observations	observation	NNS
10_1101-2020_09_09_289074	93	30	(	(	-LRB-
10_1101-2020_09_09_289074	93	31	Table	table	NN
10_1101-2020_09_09_289074	93	32	4	4	CD
10_1101-2020_09_09_289074	93	33	)	)	-RRB-
10_1101-2020_09_09_289074	93	34	.	.	.
10_1101-2020_09_09_289074	94	1	Among	among	IN
10_1101-2020_09_09_289074	94	2	all	all	DT
10_1101-2020_09_09_289074	94	3	,	,	,
10_1101-2020_09_09_289074	94	4	the	the	DT
10_1101-2020_09_09_289074	94	5	S447R	s447r	CD
10_1101-2020_09_09_289074	94	6	could	could	MD
10_1101-2020_09_09_289074	94	7	be	be	VB
10_1101-2020_09_09_289074	94	8	the	the	DT
10_1101-2020_09_09_289074	94	9	most	most	RBS
10_1101-2020_09_09_289074	94	10	interesting	interesting	JJ
10_1101-2020_09_09_289074	94	11	one	one	CD
10_1101-2020_09_09_289074	94	12	.	.	.
10_1101-2020_09_09_289074	95	1	Actually	actually	RB
10_1101-2020_09_09_289074	95	2	,	,	,
10_1101-2020_09_09_289074	95	3	a	a	DT
10_1101-2020_09_09_289074	95	4	net	net	NN
10_1101-2020_09_09_289074	95	5	positively	positively	RB
10_1101-2020_09_09_289074	95	6	charged	charge	VBN
10_1101-2020_09_09_289074	95	7	residue	residue	NN
10_1101-2020_09_09_289074	95	8	,	,	,
10_1101-2020_09_09_289074	95	9	such	such	JJ
10_1101-2020_09_09_289074	95	10	as	as	IN
10_1101-2020_09_09_289074	95	11	Arginine	Arginine	NNP
10_1101-2020_09_09_289074	95	12	(	(	-LRB-
10_1101-2020_09_09_289074	95	13	R	R	NNP
10_1101-2020_09_09_289074	95	14	)	)	-RRB-
10_1101-2020_09_09_289074	95	15	,	,	,
10_1101-2020_09_09_289074	95	16	can	can	MD
10_1101-2020_09_09_289074	95	17	establish	establish	VB
10_1101-2020_09_09_289074	95	18	a	a	DT
10_1101-2020_09_09_289074	95	19	weak	weak	JJ
10_1101-2020_09_09_289074	95	20	electrostatic	electrostatic	JJ
10_1101-2020_09_09_289074	95	21	interaction	interaction	NN
10_1101-2020_09_09_289074	95	22	to	to	IN
10_1101-2020_09_09_289074	95	23	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	95	24	Glutamate	Glutamate	NNP
10_1101-2020_09_09_289074	95	25	87	87	CD
10_1101-2020_09_09_289074	95	26	,	,	,
10_1101-2020_09_09_289074	95	27	as	as	IN
10_1101-2020_09_09_289074	95	28	suggested	suggest	VBN
10_1101-2020_09_09_289074	95	29	by	by	IN
10_1101-2020_09_09_289074	95	30	a	a	DT
10_1101-2020_09_09_289074	95	31	theoretical	theoretical	JJ
10_1101-2020_09_09_289074	95	32	model	model	NN
10_1101-2020_09_09_289074	95	33	we	-PRON-	PRP
10_1101-2020_09_09_289074	95	34	built	build	VBD
10_1101-2020_09_09_289074	95	35	.	.	.
10_1101-2020_09_09_289074	96	1	The	the	DT
10_1101-2020_09_09_289074	96	2	S477I	S477I	NNP
10_1101-2020_09_09_289074	96	3	and	and	CC
10_1101-2020_09_09_289074	96	4	S477	S477	NNP
10_1101-2020_09_09_289074	96	5	G	G	NNP
10_1101-2020_09_09_289074	96	6	could	could	MD
10_1101-2020_09_09_289074	96	7	modify	modify	VB
10_1101-2020_09_09_289074	96	8	the	the	DT
10_1101-2020_09_09_289074	96	9	conformation	conformation	NN
10_1101-2020_09_09_289074	96	10	of	of	IN
10_1101-2020_09_09_289074	96	11	a	a	DT
10_1101-2020_09_09_289074	96	12	random	random	JJ
10_1101-2020_09_09_289074	96	13	coil	coil	NN
10_1101-2020_09_09_289074	96	14	segment	segment	NN
10_1101-2020_09_09_289074	96	15	,	,	,
10_1101-2020_09_09_289074	96	16	so	so	IN
10_1101-2020_09_09_289074	96	17	it	-PRON-	PRP
10_1101-2020_09_09_289074	96	18	does	do	VBZ
10_1101-2020_09_09_289074	96	19	not	not	RB
10_1101-2020_09_09_289074	96	20	appear	appear	VB
10_1101-2020_09_09_289074	96	21	very	very	RB
10_1101-2020_09_09_289074	96	22	relevant	relevant	JJ
10_1101-2020_09_09_289074	96	23	.	.	.
10_1101-2020_09_09_289074	97	1	Conversely	conversely	RB
10_1101-2020_09_09_289074	97	2	,	,	,
10_1101-2020_09_09_289074	97	3	S477N	S477N	NNP
10_1101-2020_09_09_289074	97	4	and	and	CC
10_1101-2020_09_09_289074	97	5	S477	S477	NNP
10_1101-2020_09_09_289074	97	6	G	G	NNP
10_1101-2020_09_09_289074	97	7	could	could	MD
10_1101-2020_09_09_289074	97	8	productively	productively	RB
10_1101-2020_09_09_289074	97	9	contribute	contribute	VB
10_1101-2020_09_09_289074	97	10	to	to	IN
10_1101-2020_09_09_289074	97	11	the	the	DT
10_1101-2020_09_09_289074	97	12	Spike	Spike	NNP
10_1101-2020_09_09_289074	97	13	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	97	14	complex	complex	JJ
10_1101-2020_09_09_289074	97	15	stabilization	stabilization	NN
10_1101-2020_09_09_289074	97	16	.	.	.
10_1101-2020_09_09_289074	98	1	Of	of	RB
10_1101-2020_09_09_289074	98	2	course	course	RB
10_1101-2020_09_09_289074	98	3	,	,	,
10_1101-2020_09_09_289074	98	4	deeper	deeply	RBR
10_1101-2020_09_09_289074	98	5	theoretical	theoretical	JJ
10_1101-2020_09_09_289074	98	6	and	and	CC
10_1101-2020_09_09_289074	98	7	experimental	experimental	JJ
10_1101-2020_09_09_289074	98	8	investigations	investigation	NNS
10_1101-2020_09_09_289074	98	9	should	should	MD
10_1101-2020_09_09_289074	98	10	be	be	VB
10_1101-2020_09_09_289074	98	11	carried	carry	VBN
10_1101-2020_09_09_289074	98	12	out	out	RP
10_1101-2020_09_09_289074	98	13	to	to	TO
10_1101-2020_09_09_289074	98	14	confirm	confirm	VB
10_1101-2020_09_09_289074	98	15	this	this	DT
10_1101-2020_09_09_289074	98	16	hypothesis	hypothesis	NN
10_1101-2020_09_09_289074	98	17	.	.	.
10_1101-2020_09_09_289074	99	1	Unfortunately	unfortunately	RB
10_1101-2020_09_09_289074	99	2	,	,	,
10_1101-2020_09_09_289074	99	3	full	full	JJ
10_1101-2020_09_09_289074	99	4	-	-	HYPH
10_1101-2020_09_09_289074	99	5	scale	scale	NN
10_1101-2020_09_09_289074	99	6	simulations	simulation	NNS
10_1101-2020_09_09_289074	99	7	can	can	MD
10_1101-2020_09_09_289074	99	8	not	not	RB
10_1101-2020_09_09_289074	99	9	be	be	VB
10_1101-2020_09_09_289074	99	10	rigorously	rigorously	RB
10_1101-2020_09_09_289074	99	11	performed	perform	VBN
10_1101-2020_09_09_289074	99	12	today	today	NN
10_1101-2020_09_09_289074	99	13	because	because	IN
10_1101-2020_09_09_289074	99	14	the	the	DT
10_1101-2020_09_09_289074	99	15	available	available	JJ
10_1101-2020_09_09_289074	99	16	3D	3d	JJ
10_1101-2020_09_09_289074	99	17	structural	structural	JJ
10_1101-2020_09_09_289074	99	18	models	model	NNS
10_1101-2020_09_09_289074	99	19	report	report	VBP
10_1101-2020_09_09_289074	99	20	only	only	RB
10_1101-2020_09_09_289074	99	21	fragments	fragment	NNS
10_1101-2020_09_09_289074	99	22	of	of	IN
10_1101-2020_09_09_289074	99	23	the	the	DT
10_1101-2020_09_09_289074	99	24	complex	complex	NN
10_1101-2020_09_09_289074	99	25	between	between	IN
10_1101-2020_09_09_289074	99	26	Spike	Spike	NNP
10_1101-2020_09_09_289074	99	27	and	and	CC
10_1101-2020_09_09_289074	99	28	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	99	29	.	.	.
10_1101-2020_09_09_289074	100	1	The	the	DT
10_1101-2020_09_09_289074	100	2	third	third	JJ
10_1101-2020_09_09_289074	100	3	most	most	RBS
10_1101-2020_09_09_289074	100	4	common	common	JJ
10_1101-2020_09_09_289074	100	5	mutation	mutation	NN
10_1101-2020_09_09_289074	100	6	,	,	,
10_1101-2020_09_09_289074	100	7	N501Y	n501y	CD
10_1101-2020_09_09_289074	100	8	(	(	-LRB-
10_1101-2020_09_09_289074	100	9	Fig	fig	NN
10_1101-2020_09_09_289074	100	10	3	3	CD
10_1101-2020_09_09_289074	100	11	)	)	-RRB-
10_1101-2020_09_09_289074	100	12	,	,	,
10_1101-2020_09_09_289074	100	13	targets	target	VBZ
10_1101-2020_09_09_289074	100	14	an	an	DT
10_1101-2020_09_09_289074	100	15	AA	AA	NNP
10_1101-2020_09_09_289074	100	16	predicted	predict	VBD
10_1101-2020_09_09_289074	100	17	to	to	TO
10_1101-2020_09_09_289074	100	18	have	have	VB
10_1101-2020_09_09_289074	100	19	a	a	DT
10_1101-2020_09_09_289074	100	20	strong	strong	JJ
10_1101-2020_09_09_289074	100	21	role	role	NN
10_1101-2020_09_09_289074	100	22	in	in	IN
10_1101-2020_09_09_289074	100	23	the	the	DT
10_1101-2020_09_09_289074	100	24	interaction	interaction	NN
10_1101-2020_09_09_289074	100	25	in	in	IN
10_1101-2020_09_09_289074	100	26	all	all	DT
10_1101-2020_09_09_289074	100	27	four	four	CD
10_1101-2020_09_09_289074	100	28	models	model	NNS
10_1101-2020_09_09_289074	100	29	,	,	,
10_1101-2020_09_09_289074	100	30	sitting	sit	VBG
10_1101-2020_09_09_289074	100	31	in	in	IN
10_1101-2020_09_09_289074	100	32	the	the	DT
10_1101-2020_09_09_289074	100	33	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	100	34	Q1	Q1	NNP
10_1101-2020_09_09_289074	100	35	.	.	.
10_1101-2020_09_09_289074	101	1	N501Y	N501Y	NNP
10_1101-2020_09_09_289074	101	2	was	be	VBD
10_1101-2020_09_09_289074	101	3	detected	detect	VBN
10_1101-2020_09_09_289074	101	4	in	in	IN
10_1101-2020_09_09_289074	101	5	4,921	4,921	CD
10_1101-2020_09_09_289074	101	6	patients	patient	NNS
10_1101-2020_09_09_289074	101	7	(	(	-LRB-
10_1101-2020_09_09_289074	101	8	1.67	1.67	CD
10_1101-2020_09_09_289074	101	9	%	%	NN
10_1101-2020_09_09_289074	101	10	of	of	IN
10_1101-2020_09_09_289074	101	11	the	the	DT
10_1101-2020_09_09_289074	101	12	dataset	dataset	NN
10_1101-2020_09_09_289074	101	13	)	)	-RRB-
10_1101-2020_09_09_289074	101	14	:	:	:
10_1101-2020_09_09_289074	101	15	the	the	DT
10_1101-2020_09_09_289074	101	16	majority	majority	NN
10_1101-2020_09_09_289074	101	17	of	of	IN
10_1101-2020_09_09_289074	101	18	which	which	WDT
10_1101-2020_09_09_289074	101	19	were	be	VBD
10_1101-2020_09_09_289074	101	20	located	locate	VBN
10_1101-2020_09_09_289074	101	21	in	in	IN
10_1101-2020_09_09_289074	101	22	the	the	DT
10_1101-2020_09_09_289074	101	23	United	United	NNP
10_1101-2020_09_09_289074	101	24	Kingdom	Kingdom	NNP
10_1101-2020_09_09_289074	101	25	(	(	-LRB-
10_1101-2020_09_09_289074	101	26	29	29	CD
10_1101-2020_09_09_289074	101	27	)	)	-RRB-
10_1101-2020_09_09_289074	101	28	.	.	.
10_1101-2020_09_09_289074	102	1	From	from	IN
10_1101-2020_09_09_289074	102	2	a	a	DT
10_1101-2020_09_09_289074	102	3	structural	structural	JJ
10_1101-2020_09_09_289074	102	4	point	point	NN
10_1101-2020_09_09_289074	102	5	of	of	IN
10_1101-2020_09_09_289074	102	6	view	view	NN
10_1101-2020_09_09_289074	102	7	,	,	,
10_1101-2020_09_09_289074	102	8	we	-PRON-	PRP
10_1101-2020_09_09_289074	102	9	predict	predict	VBP
10_1101-2020_09_09_289074	102	10	that	that	IN
10_1101-2020_09_09_289074	102	11	a	a	DT
10_1101-2020_09_09_289074	102	12	substitution	substitution	NN
10_1101-2020_09_09_289074	102	13	,	,	,
10_1101-2020_09_09_289074	102	14	at	at	IN
10_1101-2020_09_09_289074	102	15	position	position	NN
10_1101-2020_09_09_289074	102	16	501	501	CD
10_1101-2020_09_09_289074	102	17	,	,	,
10_1101-2020_09_09_289074	102	18	of	of	IN
10_1101-2020_09_09_289074	102	19	an	an	DT
10_1101-2020_09_09_289074	102	20	Asparagine	Asparagine	NNP
10_1101-2020_09_09_289074	102	21	(	(	-LRB-
10_1101-2020_09_09_289074	102	22	N	n	NN
10_1101-2020_09_09_289074	102	23	)	)	-RRB-
10_1101-2020_09_09_289074	102	24	with	with	IN
10_1101-2020_09_09_289074	102	25	a	a	DT
10_1101-2020_09_09_289074	102	26	Tyrosine	Tyrosine	NNP
10_1101-2020_09_09_289074	102	27	(	(	-LRB-
10_1101-2020_09_09_289074	102	28	Y	y	NN
10_1101-2020_09_09_289074	102	29	)	)	-RRB-
10_1101-2020_09_09_289074	102	30	may	may	MD
10_1101-2020_09_09_289074	102	31	have	have	VB
10_1101-2020_09_09_289074	102	32	an	an	DT
10_1101-2020_09_09_289074	102	33	effect	effect	NN
10_1101-2020_09_09_289074	102	34	:	:	:
10_1101-2020_09_09_289074	102	35	their	-PRON-	PRP$
10_1101-2020_09_09_289074	102	36	Total	total	JJ
10_1101-2020_09_09_289074	102	37	Polar	Polar	NNP
10_1101-2020_09_09_289074	102	38	Surface	Surface	NNP
10_1101-2020_09_09_289074	102	39	Area	Area	NNP
10_1101-2020_09_09_289074	102	40	(	(	-LRB-
10_1101-2020_09_09_289074	102	41	TPSA	TPSA	NNP
10_1101-2020_09_09_289074	102	42	)	)	-RRB-
10_1101-2020_09_09_289074	102	43	,	,	,
10_1101-2020_09_09_289074	102	44	equal	equal	JJ
10_1101-2020_09_09_289074	102	45	to	to	IN
10_1101-2020_09_09_289074	102	46	101.29	101.29	CD
10_1101-2020_09_09_289074	102	47	and	and	CC
10_1101-2020_09_09_289074	102	48	to	to	TO
10_1101-2020_09_09_289074	102	49	78.43	78.43	CD
10_1101-2020_09_09_289074	102	50	Å2	å2	NN
10_1101-2020_09_09_289074	102	51	respectively	respectively	RB
10_1101-2020_09_09_289074	102	52	,	,	,
10_1101-2020_09_09_289074	102	53	is	be	VBZ
10_1101-2020_09_09_289074	102	54	different	different	JJ
10_1101-2020_09_09_289074	102	55	,	,	,
10_1101-2020_09_09_289074	102	56	however	however	RB
10_1101-2020_09_09_289074	102	57	both	both	CC
10_1101-2020_09_09_289074	102	58	their	-PRON-	PRP$
10_1101-2020_09_09_289074	102	59	sidechains	sidechain	NNS
10_1101-2020_09_09_289074	102	60	can	can	MD
10_1101-2020_09_09_289074	102	61	donate	donate	VB
10_1101-2020_09_09_289074	102	62	/	/	SYM
10_1101-2020_09_09_289074	102	63	accept	accept	VB
10_1101-2020_09_09_289074	102	64	a	a	DT
10_1101-2020_09_09_289074	102	65	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	102	66	bond	bond	NN
10_1101-2020_09_09_289074	102	67	.	.	.
10_1101-2020_09_09_289074	103	1	Therefore	therefore	RB
10_1101-2020_09_09_289074	103	2	,	,	,
10_1101-2020_09_09_289074	103	3	their	-PRON-	PRP$
10_1101-2020_09_09_289074	103	4	contribution	contribution	NN
10_1101-2020_09_09_289074	103	5	to	to	IN
10_1101-2020_09_09_289074	103	6	complex	complex	JJ
10_1101-2020_09_09_289074	103	7	stabilization	stabilization	NN
10_1101-2020_09_09_289074	103	8	may	may	MD
10_1101-2020_09_09_289074	103	9	be	be	VB
10_1101-2020_09_09_289074	103	10	slightly	slightly	RB
10_1101-2020_09_09_289074	103	11	different	different	JJ
10_1101-2020_09_09_289074	103	12	,	,	,
10_1101-2020_09_09_289074	103	13	also	also	RB
10_1101-2020_09_09_289074	103	14	taking	take	VBG
10_1101-2020_09_09_289074	103	15	into	into	IN
10_1101-2020_09_09_289074	103	16	account	account	NN
10_1101-2020_09_09_289074	103	17	the	the	DT
10_1101-2020_09_09_289074	103	18	chemical	chemical	NN
10_1101-2020_09_09_289074	103	19	environment	environment	NN
10_1101-2020_09_09_289074	103	20	.	.	.
10_1101-2020_09_09_289074	104	1	In	in	IN
10_1101-2020_09_09_289074	104	2	fact	fact	NN
10_1101-2020_09_09_289074	104	3	,	,	,
10_1101-2020_09_09_289074	104	4	the	the	DT
10_1101-2020_09_09_289074	104	5	wild	wild	JJ
10_1101-2020_09_09_289074	104	6	type	type	NN
10_1101-2020_09_09_289074	104	7	Asparagine	Asparagine	NNP
10_1101-2020_09_09_289074	104	8	501	501	CD
10_1101-2020_09_09_289074	104	9	donates	donate	VBZ
10_1101-2020_09_09_289074	104	10	one	one	CD
10_1101-2020_09_09_289074	104	11	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	104	12	bond	bond	NN
10_1101-2020_09_09_289074	104	13	to	to	IN
10_1101-2020_09_09_289074	104	14	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	104	15	Tyrosine	Tyrosine	NNP
10_1101-2020_09_09_289074	104	16	41	41	CD
10_1101-2020_09_09_289074	104	17	:	:	:
10_1101-2020_09_09_289074	104	18	such	such	PDT
10_1101-2020_09_09_289074	104	19	an	an	DT
10_1101-2020_09_09_289074	104	20	interaction	interaction	NN
10_1101-2020_09_09_289074	104	21	could	could	MD
10_1101-2020_09_09_289074	104	22	be	be	VB
10_1101-2020_09_09_289074	104	23	possible	possible	JJ
10_1101-2020_09_09_289074	104	24	also	also	RB
10_1101-2020_09_09_289074	104	25	for	for	IN
10_1101-2020_09_09_289074	104	26	N501Y	n501y	CD
10_1101-2020_09_09_289074	104	27	mutant	mutant	JJ
10_1101-2020_09_09_289074	104	28	or	or	CC
10_1101-2020_09_09_289074	104	29	,	,	,
10_1101-2020_09_09_289074	104	30	as	as	IN
10_1101-2020_09_09_289074	104	31	we	-PRON-	PRP
10_1101-2020_09_09_289074	104	32	observed	observe	VBD
10_1101-2020_09_09_289074	104	33	in	in	IN
10_1101-2020_09_09_289074	104	34	our	-PRON-	PRP$
10_1101-2020_09_09_289074	104	35	theoretical	theoretical	JJ
10_1101-2020_09_09_289074	104	36	model	model	NN
10_1101-2020_09_09_289074	104	37	,	,	,
10_1101-2020_09_09_289074	104	38	it	-PRON-	PRP
10_1101-2020_09_09_289074	104	39	could	could	MD
10_1101-2020_09_09_289074	104	40	be	be	VB
10_1101-2020_09_09_289074	104	41	replaced	replace	VBN
10_1101-2020_09_09_289074	104	42	by	by	IN
10_1101-2020_09_09_289074	104	43	pi	pi	NN
10_1101-2020_09_09_289074	104	44	-	-	HYPH
10_1101-2020_09_09_289074	104	45	pi	pi	NN
10_1101-2020_09_09_289074	104	46	stacking	stack	VBG
10_1101-2020_09_09_289074	104	47	(	(	-LRB-
10_1101-2020_09_09_289074	104	48	Figure	Figure	NNP
10_1101-2020_09_09_289074	104	49	S3	S3	NNP
10_1101-2020_09_09_289074	104	50	)	)	-RRB-
10_1101-2020_09_09_289074	104	51	.	.	.
10_1101-2020_09_09_289074	105	1	The	the	DT
10_1101-2020_09_09_289074	105	2	rapid	rapid	JJ
10_1101-2020_09_09_289074	105	3	increase	increase	NN
10_1101-2020_09_09_289074	105	4	in	in	IN
10_1101-2020_09_09_289074	105	5	frequency	frequency	NN
10_1101-2020_09_09_289074	105	6	of	of	IN
10_1101-2020_09_09_289074	105	7	mutation	mutation	NN
10_1101-2020_09_09_289074	105	8	N501Y	n501y	CD
10_1101-2020_09_09_289074	105	9	has	have	VBZ
10_1101-2020_09_09_289074	105	10	been	be	VBN
10_1101-2020_09_09_289074	105	11	recently	recently	RB
10_1101-2020_09_09_289074	105	12	observed	observe	VBN
10_1101-2020_09_09_289074	105	13	in	in	IN
10_1101-2020_09_09_289074	105	14	the	the	DT
10_1101-2020_09_09_289074	105	15	United	United	NNP
10_1101-2020_09_09_289074	105	16	Kingdom	Kingdom	NNP
10_1101-2020_09_09_289074	105	17	and	and	CC
10_1101-2020_09_09_289074	105	18	other	other	JJ
10_1101-2020_09_09_289074	105	19	countries	country	NNS
10_1101-2020_09_09_289074	105	20	,	,	,
10_1101-2020_09_09_289074	105	21	as	as	IN
10_1101-2020_09_09_289074	105	22	it	-PRON-	PRP
10_1101-2020_09_09_289074	105	23	is	be	VBZ
10_1101-2020_09_09_289074	105	24	one	one	CD
10_1101-2020_09_09_289074	105	25	of	of	IN
10_1101-2020_09_09_289074	105	26	the	the	DT
10_1101-2020_09_09_289074	105	27	variants	variant	NNS
10_1101-2020_09_09_289074	105	28	characterizing	characterize	VBG
10_1101-2020_09_09_289074	105	29	lineage	lineage	NN
10_1101-2020_09_09_289074	105	30	B1.1.7	B1.1.7	NNP
10_1101-2020_09_09_289074	105	31	(	(	-LRB-
10_1101-2020_09_09_289074	105	32	30	30	CD
10_1101-2020_09_09_289074	105	33	)	)	-RRB-
10_1101-2020_09_09_289074	105	34	.	.	.
10_1101-2020_09_09_289074	106	1	The	the	DT
10_1101-2020_09_09_289074	106	2	Asparagine	Asparagine	NNP
10_1101-2020_09_09_289074	106	3	/	/	SYM
10_1101-2020_09_09_289074	106	4	Tyrosine	Tyrosine	NNP
10_1101-2020_09_09_289074	106	5	substitution	substitution	NN
10_1101-2020_09_09_289074	106	6	in	in	IN
10_1101-2020_09_09_289074	106	7	Spike	Spike	NNP
10_1101-2020_09_09_289074	106	8	position	position	NN
10_1101-2020_09_09_289074	106	9	501	501	CD
10_1101-2020_09_09_289074	106	10	could	could	MD
10_1101-2020_09_09_289074	106	11	contribute	contribute	VB
10_1101-2020_09_09_289074	106	12	to	to	TO
10_1101-2020_09_09_289074	106	13	determine	determine	VB
10_1101-2020_09_09_289074	106	14	an	an	DT
10_1101-2020_09_09_289074	106	15	evolutionary	evolutionary	JJ
10_1101-2020_09_09_289074	106	16	advantage	advantage	NN
10_1101-2020_09_09_289074	106	17	for	for	IN
10_1101-2020_09_09_289074	106	18	this	this	DT
10_1101-2020_09_09_289074	106	19	lineage	lineage	NN
10_1101-2020_09_09_289074	106	20	,	,	,
10_1101-2020_09_09_289074	106	21	based	base	VBN
10_1101-2020_09_09_289074	106	22	on	on	IN
10_1101-2020_09_09_289074	106	23	differential	differential	JJ
10_1101-2020_09_09_289074	106	24	affinity	affinity	NN
10_1101-2020_09_09_289074	106	25	for	for	IN
10_1101-2020_09_09_289074	106	26	the	the	DT
10_1101-2020_09_09_289074	106	27	human	human	JJ
10_1101-2020_09_09_289074	106	28	receptor	receptor	NN
10_1101-2020_09_09_289074	106	29	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	106	30	(	(	-LRB-
10_1101-2020_09_09_289074	106	31	31	31	CD
10_1101-2020_09_09_289074	106	32	,	,	,
10_1101-2020_09_09_289074	106	33	32	32	CD
10_1101-2020_09_09_289074	106	34	)	)	-RRB-
10_1101-2020_09_09_289074	106	35	.	.	.
10_1101-2020_09_09_289074	107	1	A	a	DT
10_1101-2020_09_09_289074	107	2	less	less	RBR
10_1101-2020_09_09_289074	107	3	frequent	frequent	JJ
10_1101-2020_09_09_289074	107	4	mutation	mutation	NN
10_1101-2020_09_09_289074	107	5	amongst	amongst	IN
10_1101-2020_09_09_289074	107	6	those	those	DT
10_1101-2020_09_09_289074	107	7	predicted	predict	VBN
10_1101-2020_09_09_289074	107	8	to	to	TO
10_1101-2020_09_09_289074	107	9	contribute	contribute	VB
10_1101-2020_09_09_289074	107	10	to	to	IN
10_1101-2020_09_09_289074	107	11	the	the	DT
10_1101-2020_09_09_289074	107	12	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	107	13	/	/	SYM
10_1101-2020_09_09_289074	107	14	Spike	Spike	NNP
10_1101-2020_09_09_289074	107	15	interaction	interaction	NN
10_1101-2020_09_09_289074	107	16	is	be	VBZ
10_1101-2020_09_09_289074	107	17	G476S	G476S	NNP
10_1101-2020_09_09_289074	107	18	,	,	,
10_1101-2020_09_09_289074	107	19	detected	detect	VBN
10_1101-2020_09_09_289074	107	20	in	in	IN
10_1101-2020_09_09_289074	107	21	43	43	CD
10_1101-2020_09_09_289074	107	22	samples	sample	NNS
10_1101-2020_09_09_289074	107	23	(	(	-LRB-
10_1101-2020_09_09_289074	107	24	0.02	0.02	CD
10_1101-2020_09_09_289074	107	25	%	%	NN
10_1101-2020_09_09_289074	107	26	)	)	-RRB-
10_1101-2020_09_09_289074	107	27	,	,	,
10_1101-2020_09_09_289074	107	28	and	and	CC
10_1101-2020_09_09_289074	107	29	supported	support	VBN
10_1101-2020_09_09_289074	107	30	by	by	IN
10_1101-2020_09_09_289074	107	31	three	three	CD
10_1101-2020_09_09_289074	107	32	out	out	IN
10_1101-2020_09_09_289074	107	33	of	of	IN
10_1101-2020_09_09_289074	107	34	four	four	CD
10_1101-2020_09_09_289074	107	35	structural	structural	JJ
10_1101-2020_09_09_289074	107	36	models	model	NNS
10_1101-2020_09_09_289074	107	37	(	(	-LRB-
10_1101-2020_09_09_289074	107	38	Table	table	NN
10_1101-2020_09_09_289074	107	39	1	1	CD
10_1101-2020_09_09_289074	107	40	,	,	,
10_1101-2020_09_09_289074	107	41	Fig	fig	NN
10_1101-2020_09_09_289074	107	42	4	4	CD
10_1101-2020_09_09_289074	107	43	B	b	NN
10_1101-2020_09_09_289074	107	44	)	)	-RRB-
10_1101-2020_09_09_289074	107	45	.	.	.
10_1101-2020_09_09_289074	108	1	The	the	DT
10_1101-2020_09_09_289074	108	2	Glycine	Glycine	NNP
10_1101-2020_09_09_289074	108	3	(	(	-LRB-
10_1101-2020_09_09_289074	108	4	G	G	NNP
10_1101-2020_09_09_289074	108	5	)	)	-RRB-
10_1101-2020_09_09_289074	108	6	476	476	CD
10_1101-2020_09_09_289074	108	7	was	be	VBD
10_1101-2020_09_09_289074	108	8	included	include	VBN
10_1101-2020_09_09_289074	108	9	by	by	IN
10_1101-2020_09_09_289074	108	10	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	108	11	analysis	analysis	NN
10_1101-2020_09_09_289074	108	12	in	in	IN
10_1101-2020_09_09_289074	108	13	Q2	Q2	NNP
10_1101-2020_09_09_289074	108	14	:	:	:
10_1101-2020_09_09_289074	108	15	its	-PRON-	PRP$
10_1101-2020_09_09_289074	108	16	contribution	contribution	NN
10_1101-2020_09_09_289074	108	17	to	to	IN
10_1101-2020_09_09_289074	108	18	the	the	DT
10_1101-2020_09_09_289074	108	19	complex	complex	JJ
10_1101-2020_09_09_289074	108	20	stabilization	stabilization	NN
10_1101-2020_09_09_289074	108	21	is	be	VBZ
10_1101-2020_09_09_289074	108	22	weak	weak	JJ
10_1101-2020_09_09_289074	108	23	.	.	.
10_1101-2020_09_09_289074	109	1	Conversely	conversely	RB
10_1101-2020_09_09_289074	109	2	to	to	IN
10_1101-2020_09_09_289074	109	3	the	the	DT
10_1101-2020_09_09_289074	109	4	other	other	JJ
10_1101-2020_09_09_289074	109	5	mutation	mutation	NN
10_1101-2020_09_09_289074	109	6	described	describe	VBN
10_1101-2020_09_09_289074	109	7	here	here	RB
10_1101-2020_09_09_289074	109	8	,	,	,
10_1101-2020_09_09_289074	109	9	the	the	DT
10_1101-2020_09_09_289074	109	10	replacement	replacement	NN
10_1101-2020_09_09_289074	109	11	of	of	IN
10_1101-2020_09_09_289074	109	12	Glycine	Glycine	NNP
10_1101-2020_09_09_289074	109	13	476	476	CD
10_1101-2020_09_09_289074	109	14	with	with	IN
10_1101-2020_09_09_289074	109	15	a	a	DT
10_1101-2020_09_09_289074	109	16	Serine	Serine	NNP
10_1101-2020_09_09_289074	109	17	(	(	-LRB-
10_1101-2020_09_09_289074	109	18	S	S	NNP
10_1101-2020_09_09_289074	109	19	)	)	-RRB-
10_1101-2020_09_09_289074	109	20	could	could	MD
10_1101-2020_09_09_289074	109	21	have	have	VB
10_1101-2020_09_09_289074	109	22	more	more	RBR
10_1101-2020_09_09_289074	109	23	evident	evident	JJ
10_1101-2020_09_09_289074	109	24	effects	effect	NNS
10_1101-2020_09_09_289074	109	25	on	on	IN
10_1101-2020_09_09_289074	109	26	Spike	Spike	NNP
10_1101-2020_09_09_289074	109	27	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	109	28	molecular	molecular	JJ
10_1101-2020_09_09_289074	109	29	recognition	recognition	NN
10_1101-2020_09_09_289074	109	30	.	.	.
10_1101-2020_09_09_289074	110	1	In	in	IN
10_1101-2020_09_09_289074	110	2	fact	fact	NN
10_1101-2020_09_09_289074	110	3	,	,	,
10_1101-2020_09_09_289074	110	4	in	in	IN
10_1101-2020_09_09_289074	110	5	all	all	DT
10_1101-2020_09_09_289074	110	6	PDB	PDB	NNP
10_1101-2020_09_09_289074	110	7	entries	entry	NNS
10_1101-2020_09_09_289074	110	8	,	,	,
10_1101-2020_09_09_289074	110	9	the	the	DT
10_1101-2020_09_09_289074	110	10	alpha	alpha	NN
10_1101-2020_09_09_289074	110	11	carbon	carbon	NN
10_1101-2020_09_09_289074	110	12	of	of	IN
10_1101-2020_09_09_289074	110	13	this	this	DT
10_1101-2020_09_09_289074	110	14	Glycine	Glycine	NNP
10_1101-2020_09_09_289074	110	15	is	be	VBZ
10_1101-2020_09_09_289074	110	16	very	very	RB
10_1101-2020_09_09_289074	110	17	close	close	JJ
10_1101-2020_09_09_289074	110	18	,	,	,
10_1101-2020_09_09_289074	110	19	about	about	RB
10_1101-2020_09_09_289074	110	20	4	4	CD
10_1101-2020_09_09_289074	110	21	Å	å	NN
10_1101-2020_09_09_289074	110	22	,	,	,
10_1101-2020_09_09_289074	110	23	to	to	IN
10_1101-2020_09_09_289074	110	24	the	the	DT
10_1101-2020_09_09_289074	110	25	sidechain	sidechain	JJ
10_1101-2020_09_09_289074	110	26	amide	amide	NN
10_1101-2020_09_09_289074	110	27	group	group	NN
10_1101-2020_09_09_289074	110	28	of	of	IN
10_1101-2020_09_09_289074	110	29	the	the	DT
10_1101-2020_09_09_289074	110	30	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	110	31	Glutamine	Glutamine	NNP
10_1101-2020_09_09_289074	110	32	24	24	CD
10_1101-2020_09_09_289074	110	33	.	.	.
10_1101-2020_09_09_289074	111	1	Between	between	IN
10_1101-2020_09_09_289074	111	2	these	these	DT
10_1101-2020_09_09_289074	111	3	two	two	CD
10_1101-2020_09_09_289074	111	4	AAs	aa	NNS
10_1101-2020_09_09_289074	111	5	no	no	DT
10_1101-2020_09_09_289074	111	6	productive	productive	JJ
10_1101-2020_09_09_289074	111	7	interaction	interaction	NN
10_1101-2020_09_09_289074	111	8	can	can	MD
10_1101-2020_09_09_289074	111	9	be	be	VB
10_1101-2020_09_09_289074	111	10	established	establish	VBN
10_1101-2020_09_09_289074	111	11	but	but	CC
10_1101-2020_09_09_289074	111	12	the	the	DT
10_1101-2020_09_09_289074	111	13	substitution	substitution	NN
10_1101-2020_09_09_289074	111	14	of	of	IN
10_1101-2020_09_09_289074	111	15	the	the	DT
10_1101-2020_09_09_289074	111	16	Spike	Spike	NNP
10_1101-2020_09_09_289074	111	17	Glycine	Glycine	NNP
10_1101-2020_09_09_289074	111	18	with	with	IN
10_1101-2020_09_09_289074	111	19	a	a	DT
10_1101-2020_09_09_289074	111	20	Serine	Serine	NNP
10_1101-2020_09_09_289074	111	21	could	could	MD
10_1101-2020_09_09_289074	111	22	allow	allow	VB
10_1101-2020_09_09_289074	111	23	one	one	CD
10_1101-2020_09_09_289074	111	24	inter	inter	JJ
10_1101-2020_09_09_289074	111	25	-	-	JJ
10_1101-2020_09_09_289074	111	26	protein	protein	JJ
10_1101-2020_09_09_289074	111	27	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	111	28	bond	bond	NN
10_1101-2020_09_09_289074	111	29	to	to	IN
10_1101-2020_09_09_289074	111	30	.CC	.CC	:
10_1101-2020_09_09_289074	111	31	-	-	HYPH
10_1101-2020_09_09_289074	111	32	BY	by	IN
10_1101-2020_09_09_289074	111	33	-	-	HYPH
10_1101-2020_09_09_289074	111	34	NC	NC	NNP
10_1101-2020_09_09_289074	111	35	-	-	HYPH
10_1101-2020_09_09_289074	111	36	ND	ND	NNP
10_1101-2020_09_09_289074	111	37	4.0	4.0	CD
10_1101-2020_09_09_289074	111	38	International	International	NNP
10_1101-2020_09_09_289074	111	39	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	111	40	under	under	IN
10_1101-2020_09_09_289074	111	41	a	a	DT
10_1101-2020_09_09_289074	111	42	(	(	-LRB-
10_1101-2020_09_09_289074	111	43	which	which	WDT
10_1101-2020_09_09_289074	111	44	was	be	VBD
10_1101-2020_09_09_289074	111	45	not	not	RB
10_1101-2020_09_09_289074	111	46	certified	certify	VBN
10_1101-2020_09_09_289074	111	47	by	by	IN
10_1101-2020_09_09_289074	111	48	peer	peer	NN
10_1101-2020_09_09_289074	111	49	review	review	NN
10_1101-2020_09_09_289074	111	50	)	)	-RRB-
10_1101-2020_09_09_289074	111	51	is	be	VBZ
10_1101-2020_09_09_289074	111	52	the	the	DT
10_1101-2020_09_09_289074	111	53	author	author	NN
10_1101-2020_09_09_289074	111	54	/	/	SYM
10_1101-2020_09_09_289074	111	55	funder	funder	NN
10_1101-2020_09_09_289074	111	56	,	,	,
10_1101-2020_09_09_289074	111	57	who	who	WP
10_1101-2020_09_09_289074	111	58	has	have	VBZ
10_1101-2020_09_09_289074	111	59	granted	grant	VBN
10_1101-2020_09_09_289074	111	60	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	111	61	a	a	DT
10_1101-2020_09_09_289074	111	62	license	license	NN
10_1101-2020_09_09_289074	111	63	to	to	TO
10_1101-2020_09_09_289074	111	64	display	display	VB
10_1101-2020_09_09_289074	111	65	the	the	DT
10_1101-2020_09_09_289074	111	66	preprint	preprint	NN
10_1101-2020_09_09_289074	111	67	in	in	IN
10_1101-2020_09_09_289074	111	68	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	111	69	.	.	.
10_1101-2020_09_09_289074	112	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	112	2	is	be	VBZ
10_1101-2020_09_09_289074	112	3	made	make	VBN
10_1101-2020_09_09_289074	112	4	The	the	DT
10_1101-2020_09_09_289074	112	5	copyright	copyright	NN
10_1101-2020_09_09_289074	112	6	holder	holder	NN
10_1101-2020_09_09_289074	112	7	for	for	IN
10_1101-2020_09_09_289074	112	8	this	this	DT
10_1101-2020_09_09_289074	112	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	112	10	version	version	NN
10_1101-2020_09_09_289074	112	11	posted	post	VBD
10_1101-2020_09_09_289074	112	12	January	January	NNP
10_1101-2020_09_09_289074	112	13	5	5	CD
10_1101-2020_09_09_289074	112	14	,	,	,
10_1101-2020_09_09_289074	112	15	2021	2021	CD
10_1101-2020_09_09_289074	112	16	.	.	.
10_1101-2020_09_09_289074	112	17	;	;	:
10_1101-2020_09_09_289074	112	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	112	19	:	:	:
10_1101-2020_09_09_289074	112	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	112	21	preprint	preprint	NN
10_1101-2020_09_09_289074	112	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	112	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	112	24	7	7	CD
10_1101-2020_09_09_289074	112	25	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	112	26	Glutamine	Glutamine	NNP
10_1101-2020_09_09_289074	112	27	24	24	CD
10_1101-2020_09_09_289074	112	28	.	.	.
10_1101-2020_09_09_289074	113	1	Moreover	moreover	RB
10_1101-2020_09_09_289074	113	2	,	,	,
10_1101-2020_09_09_289074	113	3	G476S	G476S	NNP
10_1101-2020_09_09_289074	113	4	could	could	MD
10_1101-2020_09_09_289074	113	5	establish	establish	VB
10_1101-2020_09_09_289074	113	6	the	the	DT
10_1101-2020_09_09_289074	113	7	same	same	JJ
10_1101-2020_09_09_289074	113	8	interaction	interaction	NN
10_1101-2020_09_09_289074	113	9	with	with	IN
10_1101-2020_09_09_289074	113	10	Spike	Spike	NNP
10_1101-2020_09_09_289074	113	11	Glutamine	Glutamine	NNP
10_1101-2020_09_09_289074	113	12	478	478	CD
10_1101-2020_09_09_289074	113	13	that	that	WDT
10_1101-2020_09_09_289074	113	14	could	could	MD
10_1101-2020_09_09_289074	113	15	stabilize	stabilize	VB
10_1101-2020_09_09_289074	113	16	the	the	DT
10_1101-2020_09_09_289074	113	17	conformation	conformation	NN
10_1101-2020_09_09_289074	113	18	of	of	IN
10_1101-2020_09_09_289074	113	19	a	a	DT
10_1101-2020_09_09_289074	113	20	random	random	JJ
10_1101-2020_09_09_289074	113	21	coil	coil	NN
10_1101-2020_09_09_289074	113	22	segment	segment	NN
10_1101-2020_09_09_289074	113	23	of	of	IN
10_1101-2020_09_09_289074	113	24	the	the	DT
10_1101-2020_09_09_289074	113	25	viral	viral	JJ
10_1101-2020_09_09_289074	113	26	protein	protein	NN
10_1101-2020_09_09_289074	113	27	resulting	result	VBG
10_1101-2020_09_09_289074	113	28	in	in	IN
10_1101-2020_09_09_289074	113	29	a	a	DT
10_1101-2020_09_09_289074	113	30	better	well	JJR
10_1101-2020_09_09_289074	113	31	pre	pre	NN
10_1101-2020_09_09_289074	113	32	-	-	NN
10_1101-2020_09_09_289074	113	33	organization	organization	NN
10_1101-2020_09_09_289074	113	34	to	to	IN
10_1101-2020_09_09_289074	113	35	the	the	DT
10_1101-2020_09_09_289074	113	36	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	113	37	recognition	recognition	NN
10_1101-2020_09_09_289074	113	38	(	(	-LRB-
10_1101-2020_09_09_289074	113	39	Figure	figure	NN
10_1101-2020_09_09_289074	113	40	S4	s4	NN
10_1101-2020_09_09_289074	113	41	)	)	-RRB-
10_1101-2020_09_09_289074	113	42	.	.	.
10_1101-2020_09_09_289074	114	1	Another	another	DT
10_1101-2020_09_09_289074	114	2	Spike	Spike	NNP
10_1101-2020_09_09_289074	114	3	residue	residue	NN
10_1101-2020_09_09_289074	114	4	,	,	,
10_1101-2020_09_09_289074	114	5	predicted	predict	VBN
10_1101-2020_09_09_289074	114	6	by	by	IN
10_1101-2020_09_09_289074	114	7	our	-PRON-	PRP$
10_1101-2020_09_09_289074	114	8	analysis	analysis	NN
10_1101-2020_09_09_289074	114	9	for	for	IN
10_1101-2020_09_09_289074	114	10	playing	play	VBG
10_1101-2020_09_09_289074	114	11	a	a	DT
10_1101-2020_09_09_289074	114	12	relevant	relevant	JJ
10_1101-2020_09_09_289074	114	13	role	role	NN
10_1101-2020_09_09_289074	114	14	in	in	IN
10_1101-2020_09_09_289074	114	15	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	114	16	recognition	recognition	NN
10_1101-2020_09_09_289074	114	17	,	,	,
10_1101-2020_09_09_289074	114	18	is	be	VBZ
10_1101-2020_09_09_289074	114	19	the	the	DT
10_1101-2020_09_09_289074	114	20	Glutamine	Glutamine	NNP
10_1101-2020_09_09_289074	114	21	493	493	CD
10_1101-2020_09_09_289074	114	22	(	(	-LRB-
10_1101-2020_09_09_289074	114	23	Table	table	NN
10_1101-2020_09_09_289074	114	24	1	1	CD
10_1101-2020_09_09_289074	114	25	)	)	-RRB-
10_1101-2020_09_09_289074	114	26	.	.	.
10_1101-2020_09_09_289074	115	1	The	the	DT
10_1101-2020_09_09_289074	115	2	GISAID	GISAID	NNP
10_1101-2020_09_09_289074	115	3	data	datum	NNS
10_1101-2020_09_09_289074	115	4	revealed	reveal	VBD
10_1101-2020_09_09_289074	115	5	that	that	IN
10_1101-2020_09_09_289074	115	6	such	such	PDT
10_1101-2020_09_09_289074	115	7	an	an	DT
10_1101-2020_09_09_289074	115	8	aminoacid	aminoacid	NN
10_1101-2020_09_09_289074	115	9	is	be	VBZ
10_1101-2020_09_09_289074	115	10	rarely	rarely	RB
10_1101-2020_09_09_289074	115	11	replaced	replace	VBN
10_1101-2020_09_09_289074	115	12	by	by	IN
10_1101-2020_09_09_289074	115	13	a	a	DT
10_1101-2020_09_09_289074	115	14	Leucine	Leucine	NNP
10_1101-2020_09_09_289074	115	15	(	(	-LRB-
10_1101-2020_09_09_289074	115	16	Q493L	q493l	NN
10_1101-2020_09_09_289074	115	17	)	)	-RRB-
10_1101-2020_09_09_289074	115	18	or	or	CC
10_1101-2020_09_09_289074	115	19	by	by	IN
10_1101-2020_09_09_289074	115	20	an	an	DT
10_1101-2020_09_09_289074	115	21	Arginine	Arginine	NNP
10_1101-2020_09_09_289074	115	22	(	(	-LRB-
10_1101-2020_09_09_289074	115	23	Q493R	Q493R	NNP
10_1101-2020_09_09_289074	115	24	)	)	-RRB-
10_1101-2020_09_09_289074	115	25	.	.	.
10_1101-2020_09_09_289074	116	1	These	these	DT
10_1101-2020_09_09_289074	116	2	mutations	mutation	NNS
10_1101-2020_09_09_289074	116	3	could	could	MD
10_1101-2020_09_09_289074	116	4	affect	affect	VB
10_1101-2020_09_09_289074	116	5	the	the	DT
10_1101-2020_09_09_289074	116	6	recognition	recognition	NN
10_1101-2020_09_09_289074	116	7	of	of	IN
10_1101-2020_09_09_289074	116	8	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	116	9	in	in	IN
10_1101-2020_09_09_289074	116	10	an	an	DT
10_1101-2020_09_09_289074	116	11	opposite	opposite	JJ
10_1101-2020_09_09_289074	116	12	way	way	NN
10_1101-2020_09_09_289074	116	13	.	.	.
10_1101-2020_09_09_289074	117	1	Spike	Spike	NNP
10_1101-2020_09_09_289074	117	2	Glutamine	Glutamine	NNP
10_1101-2020_09_09_289074	117	3	493	493	CD
10_1101-2020_09_09_289074	117	4	is	be	VBZ
10_1101-2020_09_09_289074	117	5	involved	involve	VBN
10_1101-2020_09_09_289074	117	6	in	in	IN
10_1101-2020_09_09_289074	117	7	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	117	8	bond	bond	NN
10_1101-2020_09_09_289074	117	9	with	with	IN
10_1101-2020_09_09_289074	117	10	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	117	11	Glutamate	Glutamate	NNP
10_1101-2020_09_09_289074	117	12	35	35	CD
10_1101-2020_09_09_289074	117	13	.	.	.
10_1101-2020_09_09_289074	118	1	The	the	DT
10_1101-2020_09_09_289074	118	2	mutation	mutation	NN
10_1101-2020_09_09_289074	118	3	Q493L	Q493L	NNP
10_1101-2020_09_09_289074	118	4	can	can	MD
10_1101-2020_09_09_289074	118	5	not	not	RB
10_1101-2020_09_09_289074	118	6	establish	establish	VB
10_1101-2020_09_09_289074	118	7	such	such	PDT
10_1101-2020_09_09_289074	118	8	a	a	DT
10_1101-2020_09_09_289074	118	9	productive	productive	JJ
10_1101-2020_09_09_289074	118	10	contribution	contribution	NN
10_1101-2020_09_09_289074	118	11	and	and	CC
10_1101-2020_09_09_289074	118	12	could	could	MD
10_1101-2020_09_09_289074	118	13	only	only	RB
10_1101-2020_09_09_289074	118	14	hydrophobically	hydrophobically	RB
10_1101-2020_09_09_289074	118	15	interact	interact	VB
10_1101-2020_09_09_289074	118	16	to	to	IN
10_1101-2020_09_09_289074	118	17	Spike	Spike	NNP
10_1101-2020_09_09_289074	118	18	Leucine	Leucine	NNP
10_1101-2020_09_09_289074	118	19	455	455	CD
10_1101-2020_09_09_289074	118	20	.	.	.
10_1101-2020_09_09_289074	119	1	Conversely	conversely	RB
10_1101-2020_09_09_289074	119	2	,	,	,
10_1101-2020_09_09_289074	119	3	Q493R	Q493R	NNP
10_1101-2020_09_09_289074	119	4	could	could	MD
10_1101-2020_09_09_289074	119	5	locate	locate	VB
10_1101-2020_09_09_289074	119	6	its	-PRON-	PRP$
10_1101-2020_09_09_289074	119	7	net	net	NN
10_1101-2020_09_09_289074	119	8	positively	positively	RB
10_1101-2020_09_09_289074	119	9	charged	charge	VBN
10_1101-2020_09_09_289074	119	10	sidechain	sidechain	NN
10_1101-2020_09_09_289074	119	11	into	into	IN
10_1101-2020_09_09_289074	119	12	an	an	DT
10_1101-2020_09_09_289074	119	13	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	119	14	pocket	pocket	NN
10_1101-2020_09_09_289074	119	15	delimited	delimit	VBN
10_1101-2020_09_09_289074	119	16	by	by	IN
10_1101-2020_09_09_289074	119	17	Aspartate	Aspartate	NNP
10_1101-2020_09_09_289074	119	18	30	30	CD
10_1101-2020_09_09_289074	119	19	,	,	,
10_1101-2020_09_09_289074	119	20	Histidine	Histidine	NNP
10_1101-2020_09_09_289074	119	21	34	34	CD
10_1101-2020_09_09_289074	119	22	and	and	CC
10_1101-2020_09_09_289074	119	23	Glutamate	Glutamate	NNP
10_1101-2020_09_09_289074	119	24	35	35	CD
10_1101-2020_09_09_289074	119	25	.	.	.
10_1101-2020_09_09_289074	120	1	Such	such	PDT
10_1101-2020_09_09_289074	120	2	a	a	DT
10_1101-2020_09_09_289074	120	3	positioning	positioning	NN
10_1101-2020_09_09_289074	120	4	could	could	MD
10_1101-2020_09_09_289074	120	5	produce	produce	VB
10_1101-2020_09_09_289074	120	6	a	a	DT
10_1101-2020_09_09_289074	120	7	remarkable	remarkable	JJ
10_1101-2020_09_09_289074	120	8	electrostatic	electrostatic	JJ
10_1101-2020_09_09_289074	120	9	stabilization	stabilization	NN
10_1101-2020_09_09_289074	120	10	of	of	IN
10_1101-2020_09_09_289074	120	11	the	the	DT
10_1101-2020_09_09_289074	120	12	complex	complex	JJ
10_1101-2020_09_09_289074	120	13	(	(	-LRB-
10_1101-2020_09_09_289074	120	14	Figure	figure	NN
10_1101-2020_09_09_289074	120	15	S5	s5	NN
10_1101-2020_09_09_289074	120	16	)	)	-RRB-
10_1101-2020_09_09_289074	120	17	.	.	.
10_1101-2020_09_09_289074	121	1	In	in	IN
10_1101-2020_09_09_289074	121	2	general	general	JJ
10_1101-2020_09_09_289074	121	3	,	,	,
10_1101-2020_09_09_289074	121	4	we	-PRON-	PRP
10_1101-2020_09_09_289074	121	5	could	could	MD
10_1101-2020_09_09_289074	121	6	observe	observe	VB
10_1101-2020_09_09_289074	121	7	that	that	IN
10_1101-2020_09_09_289074	121	8	AAs	AAs	NNP
10_1101-2020_09_09_289074	121	9	with	with	IN
10_1101-2020_09_09_289074	121	10	the	the	DT
10_1101-2020_09_09_289074	121	11	strongest	strong	JJS
10_1101-2020_09_09_289074	121	12	evidence	evidence	NN
10_1101-2020_09_09_289074	121	13	for	for	IN
10_1101-2020_09_09_289074	121	14	interaction	interaction	NN
10_1101-2020_09_09_289074	121	15	contribution	contribution	NN
10_1101-2020_09_09_289074	121	16	in	in	IN
10_1101-2020_09_09_289074	121	17	the	the	DT
10_1101-2020_09_09_289074	121	18	Spike	Spike	NNP
10_1101-2020_09_09_289074	121	19	/	/	SYM
10_1101-2020_09_09_289074	121	20	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	121	21	interface	interface	NN
10_1101-2020_09_09_289074	121	22	tend	tend	VBP
10_1101-2020_09_09_289074	121	23	not	not	RB
10_1101-2020_09_09_289074	121	24	to	to	TO
10_1101-2020_09_09_289074	121	25	diverge	diverge	VB
10_1101-2020_09_09_289074	121	26	from	from	IN
10_1101-2020_09_09_289074	121	27	the	the	DT
10_1101-2020_09_09_289074	121	28	reference	reference	NN
10_1101-2020_09_09_289074	121	29	(	(	-LRB-
10_1101-2020_09_09_289074	121	30	Fig	fig	NN
10_1101-2020_09_09_289074	121	31	4	4	CD
10_1101-2020_09_09_289074	121	32	B	b	NN
10_1101-2020_09_09_289074	121	33	)	)	-RRB-
10_1101-2020_09_09_289074	121	34	,	,	,
10_1101-2020_09_09_289074	121	35	which	which	WDT
10_1101-2020_09_09_289074	121	36	may	may	MD
10_1101-2020_09_09_289074	121	37	indicate	indicate	VB
10_1101-2020_09_09_289074	121	38	a	a	DT
10_1101-2020_09_09_289074	121	39	solid	solid	JJ
10_1101-2020_09_09_289074	121	40	evolutionary	evolutionary	JJ
10_1101-2020_09_09_289074	121	41	constraint	constraint	NN
10_1101-2020_09_09_289074	121	42	to	to	TO
10_1101-2020_09_09_289074	121	43	maintain	maintain	VB
10_1101-2020_09_09_289074	121	44	the	the	DT
10_1101-2020_09_09_289074	121	45	interface	interface	NN
10_1101-2020_09_09_289074	121	46	residues	residue	NNS
10_1101-2020_09_09_289074	121	47	unchanged	unchanged	JJ
10_1101-2020_09_09_289074	121	48	.	.	.
10_1101-2020_09_09_289074	122	1	For	for	IN
10_1101-2020_09_09_289074	122	2	example	example	NN
10_1101-2020_09_09_289074	122	3	,	,	,
10_1101-2020_09_09_289074	122	4	one	one	CD
10_1101-2020_09_09_289074	122	5	of	of	IN
10_1101-2020_09_09_289074	122	6	the	the	DT
10_1101-2020_09_09_289074	122	7	most	most	RBS
10_1101-2020_09_09_289074	122	8	relevant	relevant	JJ
10_1101-2020_09_09_289074	122	9	1st	1st	NNP
10_1101-2020_09_09_289074	122	10	quartile	quartile	NNP
10_1101-2020_09_09_289074	122	11	AA	AA	NNP
10_1101-2020_09_09_289074	122	12	in	in	IN
10_1101-2020_09_09_289074	122	13	the	the	DT
10_1101-2020_09_09_289074	122	14	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	122	15	/	/	SYM
10_1101-2020_09_09_289074	122	16	Spike	Spike	NNP
10_1101-2020_09_09_289074	122	17	interaction	interaction	NN
10_1101-2020_09_09_289074	122	18	,	,	,
10_1101-2020_09_09_289074	122	19	Glutamine	Glutamine	NNP
10_1101-2020_09_09_289074	122	20	(	(	-LRB-
10_1101-2020_09_09_289074	122	21	Q	Q	NNP
10_1101-2020_09_09_289074	122	22	)	)	-RRB-
10_1101-2020_09_09_289074	122	23	493	493	CD
10_1101-2020_09_09_289074	122	24	,	,	,
10_1101-2020_09_09_289074	122	25	is	be	VBZ
10_1101-2020_09_09_289074	122	26	rarely	rarely	RB
10_1101-2020_09_09_289074	122	27	mutated	mutate	VBN
10_1101-2020_09_09_289074	122	28	,	,	,
10_1101-2020_09_09_289074	122	29	with	with	IN
10_1101-2020_09_09_289074	122	30	12	12	CD
10_1101-2020_09_09_289074	122	31	cases	case	NNS
10_1101-2020_09_09_289074	122	32	of	of	IN
10_1101-2020_09_09_289074	122	33	Q493L	Q493L	NNP
10_1101-2020_09_09_289074	122	34	,	,	,
10_1101-2020_09_09_289074	122	35	4	4	CD
10_1101-2020_09_09_289074	122	36	of	of	IN
10_1101-2020_09_09_289074	122	37	Q493	q493	NN
10_1101-2020_09_09_289074	122	38	*	*	NFP
10_1101-2020_09_09_289074	122	39	(	(	-LRB-
10_1101-2020_09_09_289074	122	40	the	the	DT
10_1101-2020_09_09_289074	122	41	substitution	substitution	NN
10_1101-2020_09_09_289074	122	42	of	of	IN
10_1101-2020_09_09_289074	122	43	Q493	Q493	NNP
10_1101-2020_09_09_289074	122	44	with	with	IN
10_1101-2020_09_09_289074	122	45	a	a	DT
10_1101-2020_09_09_289074	122	46	stop	stop	NN
10_1101-2020_09_09_289074	122	47	codon	codon	NN
10_1101-2020_09_09_289074	122	48	)	)	-RRB-
10_1101-2020_09_09_289074	122	49	,	,	,
10_1101-2020_09_09_289074	122	50	3	3	CD
10_1101-2020_09_09_289074	122	51	of	of	IN
10_1101-2020_09_09_289074	122	52	Q493	Q493	NNP
10_1101-2020_09_09_289074	122	53	K	K	NNP
10_1101-2020_09_09_289074	122	54	,	,	,
10_1101-2020_09_09_289074	122	55	and	and	CC
10_1101-2020_09_09_289074	122	56	1	1	CD
10_1101-2020_09_09_289074	122	57	of	of	IN
10_1101-2020_09_09_289074	122	58	Q493R	Q493R	NNP
10_1101-2020_09_09_289074	122	59	and	and	CC
10_1101-2020_09_09_289074	122	60	Q493H.	Q493H.	NNP
10_1101-2020_09_09_289074	123	1	One	one	CD
10_1101-2020_09_09_289074	123	2	possible	possible	JJ
10_1101-2020_09_09_289074	123	3	exception	exception	NN
10_1101-2020_09_09_289074	123	4	is	be	VBZ
10_1101-2020_09_09_289074	123	5	the	the	DT
10_1101-2020_09_09_289074	123	6	aforementioned	aforementioned	JJ
10_1101-2020_09_09_289074	123	7	Spike	Spike	NNP
10_1101-2020_09_09_289074	123	8	mutation	mutation	NN
10_1101-2020_09_09_289074	123	9	N501Y	n501y	CD
10_1101-2020_09_09_289074	123	10	,	,	,
10_1101-2020_09_09_289074	123	11	located	locate	VBN
10_1101-2020_09_09_289074	123	12	in	in	IN
10_1101-2020_09_09_289074	123	13	the	the	DT
10_1101-2020_09_09_289074	123	14	strongest	strong	JJS
10_1101-2020_09_09_289074	123	15	1st	1st	NN
10_1101-2020_09_09_289074	123	16	quartile	quartile	NNP
10_1101-2020_09_09_289074	123	17	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	123	18	-	-	HYPH
10_1101-2020_09_09_289074	123	19	predicted	predict	VBN
10_1101-2020_09_09_289074	123	20	AA	AA	NNP
10_1101-2020_09_09_289074	123	21	for	for	IN
10_1101-2020_09_09_289074	123	22	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	123	23	binding	binding	NN
10_1101-2020_09_09_289074	123	24	,	,	,
10_1101-2020_09_09_289074	123	25	which	which	WDT
10_1101-2020_09_09_289074	123	26	was	be	VBD
10_1101-2020_09_09_289074	123	27	found	find	VBN
10_1101-2020_09_09_289074	123	28	in	in	IN
10_1101-2020_09_09_289074	123	29	the	the	DT
10_1101-2020_09_09_289074	123	30	considerable	considerable	JJ
10_1101-2020_09_09_289074	123	31	number	number	NN
10_1101-2020_09_09_289074	123	32	of	of	IN
10_1101-2020_09_09_289074	123	33	4921	4921	CD
10_1101-2020_09_09_289074	123	34	different	different	JJ
10_1101-2020_09_09_289074	123	35	patients	patient	NNS
10_1101-2020_09_09_289074	123	36	.	.	.
10_1101-2020_09_09_289074	124	1	Mutational	mutational	JJ
10_1101-2020_09_09_289074	124	2	analysis	analysis	NN
10_1101-2020_09_09_289074	124	3	of	of	IN
10_1101-2020_09_09_289074	124	4	human	human	JJ
10_1101-2020_09_09_289074	124	5	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	124	6	We	-PRON-	PRP
10_1101-2020_09_09_289074	124	7	also	also	RB
10_1101-2020_09_09_289074	124	8	investigated	investigate	VBD
10_1101-2020_09_09_289074	124	9	the	the	DT
10_1101-2020_09_09_289074	124	10	variants	variant	NNS
10_1101-2020_09_09_289074	124	11	of	of	IN
10_1101-2020_09_09_289074	124	12	human	human	JJ
10_1101-2020_09_09_289074	124	13	ACE2	ACE2	NNS
10_1101-2020_09_09_289074	124	14	,	,	,
10_1101-2020_09_09_289074	124	15	since	since	IN
10_1101-2020_09_09_289074	124	16	these	these	DT
10_1101-2020_09_09_289074	124	17	could	could	MD
10_1101-2020_09_09_289074	124	18	constitute	constitute	VB
10_1101-2020_09_09_289074	124	19	the	the	DT
10_1101-2020_09_09_289074	124	20	basis	basis	NN
10_1101-2020_09_09_289074	124	21	for	for	IN
10_1101-2020_09_09_289074	124	22	patient-	patient-	NNP
10_1101-2020_09_09_289074	124	23	specific	specific	JJ
10_1101-2020_09_09_289074	124	24	COVID-19	covid-19	JJ
10_1101-2020_09_09_289074	124	25	susceptibility	susceptibility	NN
10_1101-2020_09_09_289074	124	26	and	and	CC
10_1101-2020_09_09_289074	124	27	severity	severity	NN
10_1101-2020_09_09_289074	124	28	.	.	.
10_1101-2020_09_09_289074	125	1	ACE2	ace2	JJ
10_1101-2020_09_09_289074	125	2	protein	protein	NN
10_1101-2020_09_09_289074	125	3	sequence	sequence	NN
10_1101-2020_09_09_289074	125	4	is	be	VBZ
10_1101-2020_09_09_289074	125	5	highly	highly	RB
10_1101-2020_09_09_289074	125	6	conserved	conserve	VBN
10_1101-2020_09_09_289074	125	7	across	across	IN
10_1101-2020_09_09_289074	125	8	vertebrates	vertebrate	NNS
10_1101-2020_09_09_289074	125	9	(	(	-LRB-
10_1101-2020_09_09_289074	125	10	33	33	CD
10_1101-2020_09_09_289074	125	11	)	)	-RRB-
10_1101-2020_09_09_289074	125	12	and	and	CC
10_1101-2020_09_09_289074	125	13	also	also	RB
10_1101-2020_09_09_289074	125	14	within	within	IN
10_1101-2020_09_09_289074	125	15	the	the	DT
10_1101-2020_09_09_289074	125	16	human	human	JJ
10_1101-2020_09_09_289074	125	17	species	specie	NNS
10_1101-2020_09_09_289074	125	18	(	(	-LRB-
10_1101-2020_09_09_289074	125	19	34	34	CD
10_1101-2020_09_09_289074	125	20	)	)	-RRB-
10_1101-2020_09_09_289074	125	21	,	,	,
10_1101-2020_09_09_289074	125	22	with	with	IN
10_1101-2020_09_09_289074	125	23	the	the	DT
10_1101-2020_09_09_289074	125	24	most	most	RBS
10_1101-2020_09_09_289074	125	25	frequent	frequent	JJ
10_1101-2020_09_09_289074	125	26	missense	missense	NN
10_1101-2020_09_09_289074	125	27	mutation	mutation	NN
10_1101-2020_09_09_289074	125	28	(	(	-LRB-
10_1101-2020_09_09_289074	125	29	rs41303171	rs41303171	FW
10_1101-2020_09_09_289074	125	30	,	,	,
10_1101-2020_09_09_289074	125	31	N720D	n720d	ADD
10_1101-2020_09_09_289074	125	32	)	)	-RRB-
10_1101-2020_09_09_289074	125	33	present	present	JJ
10_1101-2020_09_09_289074	125	34	in	in	IN
10_1101-2020_09_09_289074	125	35	1.5	1.5	CD
10_1101-2020_09_09_289074	125	36	%	%	NN
10_1101-2020_09_09_289074	125	37	of	of	IN
10_1101-2020_09_09_289074	125	38	the	the	DT
10_1101-2020_09_09_289074	125	39	world	world	NN
10_1101-2020_09_09_289074	125	40	population	population	NN
10_1101-2020_09_09_289074	125	41	(	(	-LRB-
10_1101-2020_09_09_289074	125	42	Supplementary	Supplementary	NNP
10_1101-2020_09_09_289074	125	43	File	File	NNP
10_1101-2020_09_09_289074	125	44	2	2	CD
10_1101-2020_09_09_289074	125	45	)	)	-RRB-
10_1101-2020_09_09_289074	125	46	.	.	.
10_1101-2020_09_09_289074	126	1	Our	-PRON-	PRP$
10_1101-2020_09_09_289074	126	2	analysis	analysis	NN
10_1101-2020_09_09_289074	126	3	shows	show	VBZ
10_1101-2020_09_09_289074	126	4	that	that	IN
10_1101-2020_09_09_289074	126	5	only	only	RB
10_1101-2020_09_09_289074	126	6	5	5	CD
10_1101-2020_09_09_289074	126	7	variants	variant	NNS
10_1101-2020_09_09_289074	126	8	of	of	IN
10_1101-2020_09_09_289074	126	9	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	126	10	detected	detect	VBN
10_1101-2020_09_09_289074	126	11	in	in	IN
10_1101-2020_09_09_289074	126	12	the	the	DT
10_1101-2020_09_09_289074	126	13	human	human	JJ
10_1101-2020_09_09_289074	126	14	population	population	NN
10_1101-2020_09_09_289074	126	15	are	be	VBP
10_1101-2020_09_09_289074	126	16	also	also	RB
10_1101-2020_09_09_289074	126	17	located	locate	VBN
10_1101-2020_09_09_289074	126	18	in	in	IN
10_1101-2020_09_09_289074	126	19	the	the	DT
10_1101-2020_09_09_289074	126	20	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	126	21	/	/	SYM
10_1101-2020_09_09_289074	126	22	Spike	Spike	NNP
10_1101-2020_09_09_289074	126	23	direct	direct	JJ
10_1101-2020_09_09_289074	126	24	binding	bind	VBG
10_1101-2020_09_09_289074	126	25	interface	interface	NN
10_1101-2020_09_09_289074	126	26	(	(	-LRB-
10_1101-2020_09_09_289074	126	27	Table	table	NN
10_1101-2020_09_09_289074	126	28	5	5	CD
10_1101-2020_09_09_289074	126	29	and	and	CC
10_1101-2020_09_09_289074	126	30	Fig	Fig	NNP
10_1101-2020_09_09_289074	126	31	5	5	CD
10_1101-2020_09_09_289074	126	32	)	)	-RRB-
10_1101-2020_09_09_289074	126	33	.	.	.
10_1101-2020_09_09_289074	127	1	Of	of	IN
10_1101-2020_09_09_289074	127	2	these	these	DT
10_1101-2020_09_09_289074	127	3	,	,	,
10_1101-2020_09_09_289074	127	4	rs73635825	rs73635825	NNP
10_1101-2020_09_09_289074	127	5	(	(	-LRB-
10_1101-2020_09_09_289074	127	6	causing	cause	VBG
10_1101-2020_09_09_289074	127	7	a	a	DT
10_1101-2020_09_09_289074	127	8	S19P	s19p	NN
10_1101-2020_09_09_289074	127	9	AA	AA	NNP
10_1101-2020_09_09_289074	127	10	variant	variant	NN
10_1101-2020_09_09_289074	127	11	)	)	-RRB-
10_1101-2020_09_09_289074	127	12	is	be	VBZ
10_1101-2020_09_09_289074	127	13	both	both	CC
10_1101-2020_09_09_289074	127	14	the	the	DT
10_1101-2020_09_09_289074	127	15	most	most	RBS
10_1101-2020_09_09_289074	127	16	frequent	frequent	JJ
10_1101-2020_09_09_289074	127	17	in	in	IN
10_1101-2020_09_09_289074	127	18	the	the	DT
10_1101-2020_09_09_289074	127	19	population	population	NN
10_1101-2020_09_09_289074	127	20	(	(	-LRB-
10_1101-2020_09_09_289074	127	21	0.06	0.06	CD
10_1101-2020_09_09_289074	127	22	%	%	NN
10_1101-2020_09_09_289074	127	23	)	)	-RRB-
10_1101-2020_09_09_289074	127	24	and	and	CC
10_1101-2020_09_09_289074	127	25	the	the	DT
10_1101-2020_09_09_289074	127	26	most	most	RBS
10_1101-2020_09_09_289074	127	27	relevant	relevant	JJ
10_1101-2020_09_09_289074	127	28	in	in	IN
10_1101-2020_09_09_289074	127	29	the	the	DT
10_1101-2020_09_09_289074	127	30	interaction	interaction	NN
10_1101-2020_09_09_289074	127	31	with	with	IN
10_1101-2020_09_09_289074	127	32	the	the	DT
10_1101-2020_09_09_289074	127	33	viral	viral	JJ
10_1101-2020_09_09_289074	127	34	protein	protein	NN
10_1101-2020_09_09_289074	127	35	,	,	,
10_1101-2020_09_09_289074	127	36	with	with	IN
10_1101-2020_09_09_289074	127	37	a	a	DT
10_1101-2020_09_09_289074	127	38	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	127	39	score	score	NN
10_1101-2020_09_09_289074	127	40	of	of	IN
10_1101-2020_09_09_289074	127	41	-47.6175	-47.6175	NN
10_1101-2020_09_09_289074	127	42	(	(	-LRB-
10_1101-2020_09_09_289074	127	43	Q1	Q1	NNP
10_1101-2020_09_09_289074	127	44	)	)	-RRB-
10_1101-2020_09_09_289074	127	45	and	and	CC
10_1101-2020_09_09_289074	127	46	support	support	NN
10_1101-2020_09_09_289074	127	47	from	from	IN
10_1101-2020_09_09_289074	127	48	all	all	DT
10_1101-2020_09_09_289074	127	49	4	4	CD
10_1101-2020_09_09_289074	127	50	models	model	NNS
10_1101-2020_09_09_289074	127	51	(	(	-LRB-
10_1101-2020_09_09_289074	127	52	Table	table	NN
10_1101-2020_09_09_289074	127	53	2	2	CD
10_1101-2020_09_09_289074	127	54	)	)	-RRB-
10_1101-2020_09_09_289074	127	55	.	.	.
10_1101-2020_09_09_289074	128	1	The	the	DT
10_1101-2020_09_09_289074	128	2	rs73635825	rs73635825	NNP
10_1101-2020_09_09_289074	128	3	SNP	SNP	NNP
10_1101-2020_09_09_289074	128	4	frequency	frequency	NN
10_1101-2020_09_09_289074	128	5	is	be	VBZ
10_1101-2020_09_09_289074	128	6	higher	high	JJR
10_1101-2020_09_09_289074	128	7	in	in	IN
10_1101-2020_09_09_289074	128	8	the	the	DT
10_1101-2020_09_09_289074	128	9	population	population	NN
10_1101-2020_09_09_289074	128	10	of	of	IN
10_1101-2020_09_09_289074	128	11	African	african	JJ
10_1101-2020_09_09_289074	128	12	descent	descent	NN
10_1101-2020_09_09_289074	128	13	(	(	-LRB-
10_1101-2020_09_09_289074	128	14	0.2	0.2	CD
10_1101-2020_09_09_289074	128	15	%	%	NN
10_1101-2020_09_09_289074	128	16	)	)	-RRB-
10_1101-2020_09_09_289074	128	17	.	.	.
10_1101-2020_09_09_289074	129	1	The	the	DT
10_1101-2020_09_09_289074	129	2	second	second	JJ
10_1101-2020_09_09_289074	129	3	SNP	SNP	NNP
10_1101-2020_09_09_289074	129	4	,	,	,
10_1101-2020_09_09_289074	129	5	rs143936283	rs143936283	FW
10_1101-2020_09_09_289074	129	6	(	(	-LRB-
10_1101-2020_09_09_289074	129	7	E329	E329	NNP
10_1101-2020_09_09_289074	129	8	G	g	NN
10_1101-2020_09_09_289074	129	9	,	,	,
10_1101-2020_09_09_289074	129	10	Table	table	NN
10_1101-2020_09_09_289074	129	11	5	5	CD
10_1101-2020_09_09_289074	129	12	)	)	-RRB-
10_1101-2020_09_09_289074	129	13	is	be	VBZ
10_1101-2020_09_09_289074	129	14	a	a	DT
10_1101-2020_09_09_289074	129	15	very	very	RB
10_1101-2020_09_09_289074	129	16	rare	rare	JJ
10_1101-2020_09_09_289074	129	17	allele	allele	NN
10_1101-2020_09_09_289074	129	18	(	(	-LRB-
10_1101-2020_09_09_289074	129	19	0.0066	0.0066	CD
10_1101-2020_09_09_289074	129	20	%	%	NN
10_1101-2020_09_09_289074	129	21	)	)	-RRB-
10_1101-2020_09_09_289074	129	22	in	in	IN
10_1101-2020_09_09_289074	129	23	the	the	DT
10_1101-2020_09_09_289074	129	24	European	european	JJ
10_1101-2020_09_09_289074	129	25	(	(	-LRB-
10_1101-2020_09_09_289074	129	26	non	non	JJ
10_1101-2020_09_09_289074	129	27	-	-	JJ
10_1101-2020_09_09_289074	129	28	Finnish	finnish	JJ
10_1101-2020_09_09_289074	129	29	)	)	-RRB-
10_1101-2020_09_09_289074	129	30	Asian	asian	JJ
10_1101-2020_09_09_289074	129	31	population	population	NN
10_1101-2020_09_09_289074	129	32	.	.	.
10_1101-2020_09_09_289074	130	1	The	the	DT
10_1101-2020_09_09_289074	130	2	rs766996587	rs766996587	NNP
10_1101-2020_09_09_289074	130	3	(	(	-LRB-
10_1101-2020_09_09_289074	130	4	M82I	M82I	NNP
10_1101-2020_09_09_289074	130	5	)	)	-RRB-
10_1101-2020_09_09_289074	130	6	SNP	SNP	NNP
10_1101-2020_09_09_289074	130	7	is	be	VBZ
10_1101-2020_09_09_289074	130	8	also	also	RB
10_1101-2020_09_09_289074	130	9	a	a	DT
10_1101-2020_09_09_289074	130	10	very	very	RB
10_1101-2020_09_09_289074	130	11	rare	rare	JJ
10_1101-2020_09_09_289074	130	12	allele	allele	NN
10_1101-2020_09_09_289074	130	13	(	(	-LRB-
10_1101-2020_09_09_289074	130	14	0.0066	0.0066	CD
10_1101-2020_09_09_289074	130	15	%	%	NN
10_1101-2020_09_09_289074	130	16	)	)	-RRB-
10_1101-2020_09_09_289074	130	17	found	find	VBN
10_1101-2020_09_09_289074	130	18	in	in	IN
10_1101-2020_09_09_289074	130	19	the	the	DT
10_1101-2020_09_09_289074	130	20	African	african	JJ
10_1101-2020_09_09_289074	130	21	population	population	NN
10_1101-2020_09_09_289074	130	22	.	.	.
10_1101-2020_09_09_289074	131	1	E37	E37	NNP
10_1101-2020_09_09_289074	131	2	K	K	NNP
10_1101-2020_09_09_289074	131	3	(	(	-LRB-
10_1101-2020_09_09_289074	131	4	rs146676783	rs146676783	NNP
10_1101-2020_09_09_289074	131	5	)	)	-RRB-
10_1101-2020_09_09_289074	131	6	is	be	VBZ
10_1101-2020_09_09_289074	131	7	more	more	RBR
10_1101-2020_09_09_289074	131	8	frequent	frequent	JJ
10_1101-2020_09_09_289074	131	9	in	in	IN
10_1101-2020_09_09_289074	131	10	the	the	DT
10_1101-2020_09_09_289074	131	11	Finnish	finnish	JJ
10_1101-2020_09_09_289074	131	12	(	(	-LRB-
10_1101-2020_09_09_289074	131	13	0.03	0.03	CD
10_1101-2020_09_09_289074	131	14	%	%	NN
10_1101-2020_09_09_289074	131	15	)	)	-RRB-
10_1101-2020_09_09_289074	131	16	and	and	CC
10_1101-2020_09_09_289074	131	17	G352V	G352V	NNP
10_1101-2020_09_09_289074	131	18	(	(	-LRB-
10_1101-2020_09_09_289074	131	19	rs370610075	rs370610075	NNP
10_1101-2020_09_09_289074	131	20	)	)	-RRB-
10_1101-2020_09_09_289074	131	21	in	in	IN
10_1101-2020_09_09_289074	131	22	the	the	DT
10_1101-2020_09_09_289074	131	23	European	european	JJ
10_1101-2020_09_09_289074	131	24	non	non	JJ
10_1101-2020_09_09_289074	131	25	-	-	JJ
10_1101-2020_09_09_289074	131	26	Finnish	finnish	JJ
10_1101-2020_09_09_289074	131	27	(	(	-LRB-
10_1101-2020_09_09_289074	131	28	0	0	NFP
10_1101-2020_09_09_289074	131	29	.	.	.
10_1101-2020_09_09_289074	132	1	007	007	CD
10_1101-2020_09_09_289074	132	2	%	%	NN
10_1101-2020_09_09_289074	132	3	)	)	-RRB-
10_1101-2020_09_09_289074	132	4	population	population	NN
10_1101-2020_09_09_289074	132	5	.	.	.
10_1101-2020_09_09_289074	133	1	None	none	NN
10_1101-2020_09_09_289074	133	2	of	of	IN
10_1101-2020_09_09_289074	133	3	these	these	DT
10_1101-2020_09_09_289074	133	4	five	five	CD
10_1101-2020_09_09_289074	133	5	SNPs	snp	NNS
10_1101-2020_09_09_289074	133	6	have	have	VBP
10_1101-2020_09_09_289074	133	7	a	a	DT
10_1101-2020_09_09_289074	133	8	reported	report	VBN
10_1101-2020_09_09_289074	133	9	clinical	clinical	JJ
10_1101-2020_09_09_289074	133	10	significance	significance	NN
10_1101-2020_09_09_289074	133	11	,	,	,
10_1101-2020_09_09_289074	133	12	according	accord	VBG
10_1101-2020_09_09_289074	133	13	to	to	IN
10_1101-2020_09_09_289074	133	14	dbSNP	dbsnp	NN
10_1101-2020_09_09_289074	133	15	and	and	CC
10_1101-2020_09_09_289074	133	16	literature	literature	NN
10_1101-2020_09_09_289074	133	17	search	search	NN
10_1101-2020_09_09_289074	133	18	(	(	-LRB-
10_1101-2020_09_09_289074	133	19	35	35	CD
10_1101-2020_09_09_289074	133	20	)	)	-RRB-
10_1101-2020_09_09_289074	133	21	.	.	.
10_1101-2020_09_09_289074	134	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	134	2	must	must	MD
10_1101-2020_09_09_289074	134	3	be	be	VB
10_1101-2020_09_09_289074	134	4	mentioned	mention	VBN
10_1101-2020_09_09_289074	134	5	that	that	IN
10_1101-2020_09_09_289074	134	6	M82I	M82I	NNP
10_1101-2020_09_09_289074	134	7	,	,	,
10_1101-2020_09_09_289074	134	8	together	together	RB
10_1101-2020_09_09_289074	134	9	with	with	IN
10_1101-2020_09_09_289074	134	10	S19P	s19p	NN
10_1101-2020_09_09_289074	134	11	,	,	,
10_1101-2020_09_09_289074	134	12	has	have	VBZ
10_1101-2020_09_09_289074	134	13	been	be	VBN
10_1101-2020_09_09_289074	134	14	predicted	predict	VBN
10_1101-2020_09_09_289074	134	15	to	to	TO
10_1101-2020_09_09_289074	134	16	adversely	adversely	RB
10_1101-2020_09_09_289074	134	17	affect	affect	VB
10_1101-2020_09_09_289074	134	18	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	134	19	stability	stability	NN
10_1101-2020_09_09_289074	134	20	(	(	-LRB-
10_1101-2020_09_09_289074	134	21	36	36	CD
10_1101-2020_09_09_289074	134	22	)	)	-RRB-
10_1101-2020_09_09_289074	134	23	.	.	.
10_1101-2020_09_09_289074	135	1	M82I	M82I	NNP
10_1101-2020_09_09_289074	135	2	,	,	,
10_1101-2020_09_09_289074	135	3	together	together	RB
10_1101-2020_09_09_289074	135	4	with	with	IN
10_1101-2020_09_09_289074	135	5	E329	E329	NNP
10_1101-2020_09_09_289074	135	6	G	G	NNP
10_1101-2020_09_09_289074	135	7	,	,	,
10_1101-2020_09_09_289074	135	8	has	have	VBZ
10_1101-2020_09_09_289074	135	9	been	be	VBN
10_1101-2020_09_09_289074	135	10	simulated	simulate	VBN
10_1101-2020_09_09_289074	135	11	to	to	TO
10_1101-2020_09_09_289074	135	12	increase	increase	VB
10_1101-2020_09_09_289074	135	13	binding	bind	VBG
10_1101-2020_09_09_289074	135	14	affinity	affinity	NN
10_1101-2020_09_09_289074	135	15	with	with	IN
10_1101-2020_09_09_289074	135	16	Spike	Spike	NNP
10_1101-2020_09_09_289074	135	17	when	when	WRB
10_1101-2020_09_09_289074	135	18	compared	compare	VBN
10_1101-2020_09_09_289074	135	19	to	to	IN
10_1101-2020_09_09_289074	135	20	wild	wild	JJ
10_1101-2020_09_09_289074	135	21	type	type	NN
10_1101-2020_09_09_289074	135	22	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	135	23	,	,	,
10_1101-2020_09_09_289074	135	24	hypothesizing	hypothesize	VBG
10_1101-2020_09_09_289074	135	25	greater	great	JJR
10_1101-2020_09_09_289074	135	26	susceptibility	susceptibility	NN
10_1101-2020_09_09_289074	135	27	to	to	IN
10_1101-2020_09_09_289074	135	28	SARS	SARS	NNP
10_1101-2020_09_09_289074	135	29	-	-	HYPH
10_1101-2020_09_09_289074	135	30	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	135	31	for	for	IN
10_1101-2020_09_09_289074	135	32	patients	patient	NNS
10_1101-2020_09_09_289074	135	33	carrying	carry	VBG
10_1101-2020_09_09_289074	135	34	these	these	DT
10_1101-2020_09_09_289074	135	35	variants	variant	NNS
10_1101-2020_09_09_289074	135	36	(	(	-LRB-
10_1101-2020_09_09_289074	135	37	37	37	CD
10_1101-2020_09_09_289074	135	38	)	)	-RRB-
10_1101-2020_09_09_289074	135	39	.	.	.
10_1101-2020_09_09_289074	136	1	Instead	instead	RB
10_1101-2020_09_09_289074	136	2	,	,	,
10_1101-2020_09_09_289074	136	3	E37	E37	NNP
10_1101-2020_09_09_289074	136	4	K	K	NNP
10_1101-2020_09_09_289074	136	5	(	(	-LRB-
10_1101-2020_09_09_289074	136	6	37	37	CD
10_1101-2020_09_09_289074	136	7	)	)	-RRB-
10_1101-2020_09_09_289074	136	8	and	and	CC
10_1101-2020_09_09_289074	136	9	G352V	g352v	CD
10_1101-2020_09_09_289074	136	10	(	(	-LRB-
10_1101-2020_09_09_289074	136	11	38	38	CD
10_1101-2020_09_09_289074	136	12	)	)	-RRB-
10_1101-2020_09_09_289074	136	13	were	be	VBD
10_1101-2020_09_09_289074	136	14	predicted	predict	VBN
10_1101-2020_09_09_289074	136	15	to	to	TO
10_1101-2020_09_09_289074	136	16	possess	possess	VB
10_1101-2020_09_09_289074	136	17	a	a	DT
10_1101-2020_09_09_289074	136	18	lower	low	JJR
10_1101-2020_09_09_289074	136	19	affinity	affinity	NN
10_1101-2020_09_09_289074	136	20	with	with	IN
10_1101-2020_09_09_289074	136	21	Spike	Spike	NNP
10_1101-2020_09_09_289074	136	22	,	,	,
10_1101-2020_09_09_289074	136	23	suggesting	suggest	VBG
10_1101-2020_09_09_289074	136	24	lower	low	JJR
10_1101-2020_09_09_289074	136	25	susceptibility	susceptibility	NN
10_1101-2020_09_09_289074	136	26	to	to	IN
10_1101-2020_09_09_289074	136	27	the	the	DT
10_1101-2020_09_09_289074	136	28	infection	infection	NN
10_1101-2020_09_09_289074	136	29	.	.	.
10_1101-2020_09_09_289074	137	1	However	however	RB
10_1101-2020_09_09_289074	137	2	,	,	,
10_1101-2020_09_09_289074	137	3	while	while	IN
10_1101-2020_09_09_289074	137	4	describing	describe	VBG
10_1101-2020_09_09_289074	137	5	.CC	.CC	NFP
10_1101-2020_09_09_289074	137	6	-	-	:
10_1101-2020_09_09_289074	137	7	BY	by	IN
10_1101-2020_09_09_289074	137	8	-	-	HYPH
10_1101-2020_09_09_289074	137	9	NC	NC	NNP
10_1101-2020_09_09_289074	137	10	-	-	HYPH
10_1101-2020_09_09_289074	137	11	ND	ND	NNP
10_1101-2020_09_09_289074	137	12	4.0	4.0	CD
10_1101-2020_09_09_289074	137	13	International	International	NNP
10_1101-2020_09_09_289074	137	14	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	137	15	under	under	IN
10_1101-2020_09_09_289074	137	16	a	a	DT
10_1101-2020_09_09_289074	137	17	(	(	-LRB-
10_1101-2020_09_09_289074	137	18	which	which	WDT
10_1101-2020_09_09_289074	137	19	was	be	VBD
10_1101-2020_09_09_289074	137	20	not	not	RB
10_1101-2020_09_09_289074	137	21	certified	certify	VBN
10_1101-2020_09_09_289074	137	22	by	by	IN
10_1101-2020_09_09_289074	137	23	peer	peer	NN
10_1101-2020_09_09_289074	137	24	review	review	NN
10_1101-2020_09_09_289074	137	25	)	)	-RRB-
10_1101-2020_09_09_289074	137	26	is	be	VBZ
10_1101-2020_09_09_289074	137	27	the	the	DT
10_1101-2020_09_09_289074	137	28	author	author	NN
10_1101-2020_09_09_289074	137	29	/	/	SYM
10_1101-2020_09_09_289074	137	30	funder	funder	NN
10_1101-2020_09_09_289074	137	31	,	,	,
10_1101-2020_09_09_289074	137	32	who	who	WP
10_1101-2020_09_09_289074	137	33	has	have	VBZ
10_1101-2020_09_09_289074	137	34	granted	grant	VBN
10_1101-2020_09_09_289074	137	35	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	137	36	a	a	DT
10_1101-2020_09_09_289074	137	37	license	license	NN
10_1101-2020_09_09_289074	137	38	to	to	TO
10_1101-2020_09_09_289074	137	39	display	display	VB
10_1101-2020_09_09_289074	137	40	the	the	DT
10_1101-2020_09_09_289074	137	41	preprint	preprint	NN
10_1101-2020_09_09_289074	137	42	in	in	IN
10_1101-2020_09_09_289074	137	43	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	137	44	.	.	.
10_1101-2020_09_09_289074	138	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	138	2	is	be	VBZ
10_1101-2020_09_09_289074	138	3	made	make	VBN
10_1101-2020_09_09_289074	138	4	The	the	DT
10_1101-2020_09_09_289074	138	5	copyright	copyright	NN
10_1101-2020_09_09_289074	138	6	holder	holder	NN
10_1101-2020_09_09_289074	138	7	for	for	IN
10_1101-2020_09_09_289074	138	8	this	this	DT
10_1101-2020_09_09_289074	138	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	138	10	version	version	NN
10_1101-2020_09_09_289074	138	11	posted	post	VBD
10_1101-2020_09_09_289074	138	12	January	January	NNP
10_1101-2020_09_09_289074	138	13	5	5	CD
10_1101-2020_09_09_289074	138	14	,	,	,
10_1101-2020_09_09_289074	138	15	2021	2021	CD
10_1101-2020_09_09_289074	138	16	.	.	.
10_1101-2020_09_09_289074	138	17	;	;	:
10_1101-2020_09_09_289074	138	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	138	19	:	:	:
10_1101-2020_09_09_289074	138	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	138	21	preprint	preprint	NN
10_1101-2020_09_09_289074	138	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	138	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	138	24	8	8	CD
10_1101-2020_09_09_289074	138	25	potential	potential	JJ
10_1101-2020_09_09_289074	138	26	explanations	explanation	NNS
10_1101-2020_09_09_289074	138	27	to	to	IN
10_1101-2020_09_09_289074	138	28	the	the	DT
10_1101-2020_09_09_289074	138	29	existence	existence	NN
10_1101-2020_09_09_289074	138	30	of	of	IN
10_1101-2020_09_09_289074	138	31	a	a	DT
10_1101-2020_09_09_289074	138	32	possible	possible	JJ
10_1101-2020_09_09_289074	138	33	predisposing	predisposing	JJ
10_1101-2020_09_09_289074	138	34	genetic	genetic	JJ
10_1101-2020_09_09_289074	138	35	background	background	NN
10_1101-2020_09_09_289074	138	36	to	to	IN
10_1101-2020_09_09_289074	138	37	infection	infection	NN
10_1101-2020_09_09_289074	138	38	,	,	,
10_1101-2020_09_09_289074	138	39	all	all	PDT
10_1101-2020_09_09_289074	138	40	these	these	DT
10_1101-2020_09_09_289074	138	41	studies	study	NNS
10_1101-2020_09_09_289074	138	42	remain	remain	VBP
10_1101-2020_09_09_289074	138	43	inconclusive	inconclusive	JJ
10_1101-2020_09_09_289074	138	44	in	in	IN
10_1101-2020_09_09_289074	138	45	linking	link	VBG
10_1101-2020_09_09_289074	138	46	allele	allele	NNP
10_1101-2020_09_09_289074	138	47	variants	variant	NNS
10_1101-2020_09_09_289074	138	48	to	to	IN
10_1101-2020_09_09_289074	138	49	COVID-19	covid-19	JJ
10_1101-2020_09_09_289074	138	50	susceptibility	susceptibility	NN
10_1101-2020_09_09_289074	138	51	.	.	.
10_1101-2020_09_09_289074	139	1	Structurally	structurally	RB
10_1101-2020_09_09_289074	139	2	,	,	,
10_1101-2020_09_09_289074	139	3	the	the	DT
10_1101-2020_09_09_289074	139	4	S19P	s19p	NN
10_1101-2020_09_09_289074	139	5	variant	variant	JJ
10_1101-2020_09_09_289074	139	6	may	may	MD
10_1101-2020_09_09_289074	139	7	greatly	greatly	RB
10_1101-2020_09_09_289074	139	8	differ	differ	VB
10_1101-2020_09_09_289074	139	9	from	from	IN
10_1101-2020_09_09_289074	139	10	the	the	DT
10_1101-2020_09_09_289074	139	11	reference	reference	NN
10_1101-2020_09_09_289074	139	12	sequence	sequence	NN
10_1101-2020_09_09_289074	139	13	in	in	IN
10_1101-2020_09_09_289074	139	14	the	the	DT
10_1101-2020_09_09_289074	139	15	interaction	interaction	NN
10_1101-2020_09_09_289074	139	16	with	with	IN
10_1101-2020_09_09_289074	139	17	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	139	18	:	:	:
10_1101-2020_09_09_289074	139	19	Serine	Serine	NNP
10_1101-2020_09_09_289074	139	20	(	(	-LRB-
10_1101-2020_09_09_289074	139	21	S	S	NNP
10_1101-2020_09_09_289074	139	22	)	)	-RRB-
10_1101-2020_09_09_289074	139	23	is	be	VBZ
10_1101-2020_09_09_289074	139	24	a	a	DT
10_1101-2020_09_09_289074	139	25	polar	polar	JJ
10_1101-2020_09_09_289074	139	26	residue	residue	NN
10_1101-2020_09_09_289074	139	27	,	,	,
10_1101-2020_09_09_289074	139	28	able	able	JJ
10_1101-2020_09_09_289074	139	29	to	to	TO
10_1101-2020_09_09_289074	139	30	accept	accept	VB
10_1101-2020_09_09_289074	139	31	and	and	CC
10_1101-2020_09_09_289074	139	32	donate	donate	VB
10_1101-2020_09_09_289074	139	33	,	,	,
10_1101-2020_09_09_289074	139	34	by	by	IN
10_1101-2020_09_09_289074	139	35	means	mean	NNS
10_1101-2020_09_09_289074	139	36	of	of	IN
10_1101-2020_09_09_289074	139	37	its	-PRON-	PRP$
10_1101-2020_09_09_289074	139	38	side	side	NN
10_1101-2020_09_09_289074	139	39	chain	chain	NN
10_1101-2020_09_09_289074	139	40	alcoholic	alcoholic	JJ
10_1101-2020_09_09_289074	139	41	group	group	NN
10_1101-2020_09_09_289074	139	42	,	,	,
10_1101-2020_09_09_289074	139	43	a	a	DT
10_1101-2020_09_09_289074	139	44	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	139	45	bond	bond	NN
10_1101-2020_09_09_289074	139	46	.	.	.
10_1101-2020_09_09_289074	140	1	Proline	Proline	NNP
10_1101-2020_09_09_289074	140	2	(	(	-LRB-
10_1101-2020_09_09_289074	140	3	P	p	NN
10_1101-2020_09_09_289074	140	4	)	)	-RRB-
10_1101-2020_09_09_289074	140	5	,	,	,
10_1101-2020_09_09_289074	140	6	on	on	IN
10_1101-2020_09_09_289074	140	7	the	the	DT
10_1101-2020_09_09_289074	140	8	other	other	JJ
10_1101-2020_09_09_289074	140	9	hand	hand	NN
10_1101-2020_09_09_289074	140	10	,	,	,
10_1101-2020_09_09_289074	140	11	can	can	MD
10_1101-2020_09_09_289074	140	12	not	not	RB
10_1101-2020_09_09_289074	140	13	be	be	VB
10_1101-2020_09_09_289074	140	14	involved	involve	VBN
10_1101-2020_09_09_289074	140	15	in	in	IN
10_1101-2020_09_09_289074	140	16	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	140	17	bonding	bonding	NN
10_1101-2020_09_09_289074	140	18	,	,	,
10_1101-2020_09_09_289074	140	19	and	and	CC
10_1101-2020_09_09_289074	140	20	therefore	therefore	RB
10_1101-2020_09_09_289074	140	21	should	should	MD
10_1101-2020_09_09_289074	140	22	establish	establish	VB
10_1101-2020_09_09_289074	140	23	a	a	DT
10_1101-2020_09_09_289074	140	24	weaker	weak	JJR
10_1101-2020_09_09_289074	140	25	interaction	interaction	NN
10_1101-2020_09_09_289074	140	26	with	with	IN
10_1101-2020_09_09_289074	140	27	Spike	Spike	NNP
10_1101-2020_09_09_289074	140	28	.	.	.
10_1101-2020_09_09_289074	141	1	In	in	IN
10_1101-2020_09_09_289074	141	2	fact	fact	NN
10_1101-2020_09_09_289074	141	3	,	,	,
10_1101-2020_09_09_289074	141	4	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	141	5	Serine	Serine	NNP
10_1101-2020_09_09_289074	141	6	19	19	CD
10_1101-2020_09_09_289074	141	7	sidechain	sidechain	JJ
10_1101-2020_09_09_289074	141	8	donates	donate	VBZ
10_1101-2020_09_09_289074	141	9	a	a	DT
10_1101-2020_09_09_289074	141	10	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	141	11	bond	bond	NN
10_1101-2020_09_09_289074	141	12	to	to	IN
10_1101-2020_09_09_289074	141	13	Spike	Spike	NNP
10_1101-2020_09_09_289074	141	14	Alanine	Alanine	NNP
10_1101-2020_09_09_289074	141	15	475	475	CD
10_1101-2020_09_09_289074	141	16	backbone	backbone	NN
10_1101-2020_09_09_289074	141	17	(	(	-LRB-
10_1101-2020_09_09_289074	141	18	Figure	Figure	NNP
10_1101-2020_09_09_289074	141	19	S6	s6	NN
10_1101-2020_09_09_289074	141	20	)	)	-RRB-
10_1101-2020_09_09_289074	141	21	and	and	CC
10_1101-2020_09_09_289074	141	22	potentially	potentially	RB
10_1101-2020_09_09_289074	141	23	could	could	MD
10_1101-2020_09_09_289074	141	24	establish	establish	VB
10_1101-2020_09_09_289074	141	25	the	the	DT
10_1101-2020_09_09_289074	141	26	same	same	JJ
10_1101-2020_09_09_289074	141	27	interaction	interaction	NN
10_1101-2020_09_09_289074	141	28	with	with	IN
10_1101-2020_09_09_289074	141	29	Spike	Spike	NNP
10_1101-2020_09_09_289074	141	30	Glycine	Glycine	NNP
10_1101-2020_09_09_289074	141	31	(	(	-LRB-
10_1101-2020_09_09_289074	141	32	G	G	NNP
10_1101-2020_09_09_289074	141	33	)	)	-RRB-
10_1101-2020_09_09_289074	141	34	476	476	CD
10_1101-2020_09_09_289074	141	35	,	,	,
10_1101-2020_09_09_289074	141	36	which	which	WDT
10_1101-2020_09_09_289074	141	37	could	could	MD
10_1101-2020_09_09_289074	141	38	also	also	RB
10_1101-2020_09_09_289074	141	39	be	be	VB
10_1101-2020_09_09_289074	141	40	mutated	mutate	VBN
10_1101-2020_09_09_289074	141	41	(	(	-LRB-
10_1101-2020_09_09_289074	141	42	Table	table	NN
10_1101-2020_09_09_289074	141	43	4	4	CD
10_1101-2020_09_09_289074	141	44	)	)	-RRB-
10_1101-2020_09_09_289074	141	45	.	.	.
10_1101-2020_09_09_289074	142	1	Both	both	DT
10_1101-2020_09_09_289074	142	2	Methionine	Methionine	NNP
10_1101-2020_09_09_289074	142	3	(	(	-LRB-
10_1101-2020_09_09_289074	142	4	M	M	NNP
10_1101-2020_09_09_289074	142	5	)	)	-RRB-
10_1101-2020_09_09_289074	142	6	82	82	CD
10_1101-2020_09_09_289074	142	7	and	and	CC
10_1101-2020_09_09_289074	142	8	Glutamate	Glutamate	NNP
10_1101-2020_09_09_289074	142	9	(	(	-LRB-
10_1101-2020_09_09_289074	142	10	E	E	NNP
10_1101-2020_09_09_289074	142	11	)	)	-RRB-
10_1101-2020_09_09_289074	142	12	329	329	CD
10_1101-2020_09_09_289074	142	13	are	be	VBP
10_1101-2020_09_09_289074	142	14	in	in	IN
10_1101-2020_09_09_289074	142	15	Q3	Q3	NNP
10_1101-2020_09_09_289074	142	16	minimally	minimally	RB
10_1101-2020_09_09_289074	142	17	contributing	contribute	VBG
10_1101-2020_09_09_289074	142	18	to	to	IN
10_1101-2020_09_09_289074	142	19	Spike	Spike	NNP
10_1101-2020_09_09_289074	142	20	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	142	21	recognition	recognition	NN
10_1101-2020_09_09_289074	142	22	(	(	-LRB-
10_1101-2020_09_09_289074	142	23	Figures	figure	NNS
10_1101-2020_09_09_289074	142	24	S7	S7	NNP
10_1101-2020_09_09_289074	142	25	and	and	CC
10_1101-2020_09_09_289074	142	26	S8	S8	NNP
10_1101-2020_09_09_289074	142	27	)	)	-RRB-
10_1101-2020_09_09_289074	142	28	.	.	.
10_1101-2020_09_09_289074	143	1	They	-PRON-	PRP
10_1101-2020_09_09_289074	143	2	are	be	VBP
10_1101-2020_09_09_289074	143	3	located	locate	VBN
10_1101-2020_09_09_289074	143	4	within	within	IN
10_1101-2020_09_09_289074	143	5	two	two	CD
10_1101-2020_09_09_289074	143	6	alpha	alpha	NN
10_1101-2020_09_09_289074	143	7	helices	helix	NNS
10_1101-2020_09_09_289074	143	8	so	so	IN
10_1101-2020_09_09_289074	143	9	their	-PRON-	PRP$
10_1101-2020_09_09_289074	143	10	mutation	mutation	NN
10_1101-2020_09_09_289074	143	11	could	could	MD
10_1101-2020_09_09_289074	143	12	modify	modify	VB
10_1101-2020_09_09_289074	143	13	the	the	DT
10_1101-2020_09_09_289074	143	14	secondary	secondary	JJ
10_1101-2020_09_09_289074	143	15	structure	structure	NN
10_1101-2020_09_09_289074	143	16	of	of	IN
10_1101-2020_09_09_289074	143	17	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	143	18	corresponding	correspond	VBG
10_1101-2020_09_09_289074	143	19	to	to	IN
10_1101-2020_09_09_289074	143	20	a	a	DT
10_1101-2020_09_09_289074	143	21	different	different	JJ
10_1101-2020_09_09_289074	143	22	affinity	affinity	NN
10_1101-2020_09_09_289074	143	23	against	against	IN
10_1101-2020_09_09_289074	143	24	Spike	Spike	NNP
10_1101-2020_09_09_289074	143	25	.	.	.
10_1101-2020_09_09_289074	144	1	Such	such	PDT
10_1101-2020_09_09_289074	144	2	a	a	DT
10_1101-2020_09_09_289074	144	3	possibility	possibility	NN
10_1101-2020_09_09_289074	144	4	should	should	MD
10_1101-2020_09_09_289074	144	5	be	be	VB
10_1101-2020_09_09_289074	144	6	more	more	RBR
10_1101-2020_09_09_289074	144	7	evident	evident	JJ
10_1101-2020_09_09_289074	144	8	in	in	IN
10_1101-2020_09_09_289074	144	9	the	the	DT
10_1101-2020_09_09_289074	144	10	case	case	NN
10_1101-2020_09_09_289074	144	11	of	of	IN
10_1101-2020_09_09_289074	144	12	E329	E329	NNP
10_1101-2020_09_09_289074	144	13	G	G	NNP
10_1101-2020_09_09_289074	144	14	because	because	IN
10_1101-2020_09_09_289074	144	15	Glutamate	Glutamate	NNP
10_1101-2020_09_09_289074	144	16	329	329	CD
10_1101-2020_09_09_289074	144	17	sidechain	sidechain	NN
10_1101-2020_09_09_289074	144	18	is	be	VBZ
10_1101-2020_09_09_289074	144	19	involved	involve	VBN
10_1101-2020_09_09_289074	144	20	in	in	IN
10_1101-2020_09_09_289074	144	21	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	144	22	bond	bond	NN
10_1101-2020_09_09_289074	144	23	with	with	IN
10_1101-2020_09_09_289074	144	24	ACE-2	ACE-2	NNP
10_1101-2020_09_09_289074	144	25	Glutamine	Glutamine	NNP
10_1101-2020_09_09_289074	144	26	325	325	CD
10_1101-2020_09_09_289074	144	27	.	.	.
10_1101-2020_09_09_289074	145	1	Discussion	Discussion	NNP
10_1101-2020_09_09_289074	145	2	SARS	SARS	NNP
10_1101-2020_09_09_289074	145	3	-	-	HYPH
10_1101-2020_09_09_289074	145	4	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	145	5	Spike	Spike	NNP
10_1101-2020_09_09_289074	145	6	evolved	evolve	VBD
10_1101-2020_09_09_289074	145	7	through	through	IN
10_1101-2020_09_09_289074	145	8	a	a	DT
10_1101-2020_09_09_289074	145	9	series	series	NN
10_1101-2020_09_09_289074	145	10	of	of	IN
10_1101-2020_09_09_289074	145	11	adaptive	adaptive	JJ
10_1101-2020_09_09_289074	145	12	mutations	mutation	NNS
10_1101-2020_09_09_289074	145	13	that	that	WDT
10_1101-2020_09_09_289074	145	14	increased	increase	VBD
10_1101-2020_09_09_289074	145	15	its	-PRON-	PRP$
10_1101-2020_09_09_289074	145	16	affinity	affinity	NN
10_1101-2020_09_09_289074	145	17	for	for	IN
10_1101-2020_09_09_289074	145	18	the	the	DT
10_1101-2020_09_09_289074	145	19	human	human	JJ
10_1101-2020_09_09_289074	145	20	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	145	21	receptor	receptor	NN
10_1101-2020_09_09_289074	145	22	(	(	-LRB-
10_1101-2020_09_09_289074	145	23	39	39	CD
10_1101-2020_09_09_289074	145	24	)	)	-RRB-
10_1101-2020_09_09_289074	145	25	.	.	.
10_1101-2020_09_09_289074	146	1	There	there	EX
10_1101-2020_09_09_289074	146	2	is	be	VBZ
10_1101-2020_09_09_289074	146	3	no	no	DT
10_1101-2020_09_09_289074	146	4	reason	reason	NN
10_1101-2020_09_09_289074	146	5	to	to	TO
10_1101-2020_09_09_289074	146	6	believe	believe	VB
10_1101-2020_09_09_289074	146	7	that	that	IN
10_1101-2020_09_09_289074	146	8	the	the	DT
10_1101-2020_09_09_289074	146	9	evolution	evolution	NN
10_1101-2020_09_09_289074	146	10	and	and	CC
10_1101-2020_09_09_289074	146	11	adaptation	adaptation	NN
10_1101-2020_09_09_289074	146	12	of	of	IN
10_1101-2020_09_09_289074	146	13	the	the	DT
10_1101-2020_09_09_289074	146	14	virus	virus	NN
10_1101-2020_09_09_289074	146	15	will	will	MD
10_1101-2020_09_09_289074	146	16	stop	stop	VB
10_1101-2020_09_09_289074	146	17	,	,	,
10_1101-2020_09_09_289074	146	18	making	make	VBG
10_1101-2020_09_09_289074	146	19	continuous	continuous	JJ
10_1101-2020_09_09_289074	146	20	sequencing	sequencing	NN
10_1101-2020_09_09_289074	146	21	and	and	CC
10_1101-2020_09_09_289074	146	22	mutational	mutational	JJ
10_1101-2020_09_09_289074	146	23	tracking	tracking	NN
10_1101-2020_09_09_289074	146	24	studies	study	NNS
10_1101-2020_09_09_289074	146	25	of	of	IN
10_1101-2020_09_09_289074	146	26	paramount	paramount	JJ
10_1101-2020_09_09_289074	146	27	importance	importance	NN
10_1101-2020_09_09_289074	146	28	to	to	TO
10_1101-2020_09_09_289074	146	29	strategically	strategically	RB
10_1101-2020_09_09_289074	146	30	contain	contain	VB
10_1101-2020_09_09_289074	146	31	COVID-19	COVID-19	,
10_1101-2020_09_09_289074	146	32	(	(	-LRB-
10_1101-2020_09_09_289074	146	33	40	40	CD
10_1101-2020_09_09_289074	146	34	)	)	-RRB-
10_1101-2020_09_09_289074	146	35	.	.	.
10_1101-2020_09_09_289074	147	1	In	in	IN
10_1101-2020_09_09_289074	147	2	our	-PRON-	PRP$
10_1101-2020_09_09_289074	147	3	study	study	NN
10_1101-2020_09_09_289074	147	4	,	,	,
10_1101-2020_09_09_289074	147	5	we	-PRON-	PRP
10_1101-2020_09_09_289074	147	6	highlighted	highlight	VBD
10_1101-2020_09_09_289074	147	7	which	which	WDT
10_1101-2020_09_09_289074	147	8	specific	specific	JJ
10_1101-2020_09_09_289074	147	9	locations	location	NNS
10_1101-2020_09_09_289074	147	10	of	of	IN
10_1101-2020_09_09_289074	147	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	147	12	can	can	MD
10_1101-2020_09_09_289074	147	13	influence	influence	VB
10_1101-2020_09_09_289074	147	14	the	the	DT
10_1101-2020_09_09_289074	147	15	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	147	16	molecular	molecular	JJ
10_1101-2020_09_09_289074	147	17	recognition	recognition	NN
10_1101-2020_09_09_289074	147	18	,	,	,
10_1101-2020_09_09_289074	147	19	required	require	VBN
10_1101-2020_09_09_289074	147	20	for	for	IN
10_1101-2020_09_09_289074	147	21	the	the	DT
10_1101-2020_09_09_289074	147	22	viral	viral	JJ
10_1101-2020_09_09_289074	147	23	entry	entry	NN
10_1101-2020_09_09_289074	147	24	into	into	IN
10_1101-2020_09_09_289074	147	25	the	the	DT
10_1101-2020_09_09_289074	147	26	host	host	NN
10_1101-2020_09_09_289074	147	27	cell	cell	NN
10_1101-2020_09_09_289074	147	28	(	(	-LRB-
10_1101-2020_09_09_289074	147	29	5	5	CD
10_1101-2020_09_09_289074	147	30	)	)	-RRB-
10_1101-2020_09_09_289074	147	31	.	.	.
10_1101-2020_09_09_289074	148	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	148	2	further	further	RB
10_1101-2020_09_09_289074	148	3	showed	show	VBD
10_1101-2020_09_09_289074	148	4	that	that	IN
10_1101-2020_09_09_289074	148	5	some	some	DT
10_1101-2020_09_09_289074	148	6	mutations	mutation	NNS
10_1101-2020_09_09_289074	148	7	are	be	VBP
10_1101-2020_09_09_289074	148	8	already	already	RB
10_1101-2020_09_09_289074	148	9	present	present	JJ
10_1101-2020_09_09_289074	148	10	in	in	IN
10_1101-2020_09_09_289074	148	11	the	the	DT
10_1101-2020_09_09_289074	148	12	SARS	SARS	NNP
10_1101-2020_09_09_289074	148	13	-	-	HYPH
10_1101-2020_09_09_289074	148	14	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	148	15	population	population	NN
10_1101-2020_09_09_289074	148	16	that	that	WDT
10_1101-2020_09_09_289074	148	17	may	may	MD
10_1101-2020_09_09_289074	148	18	weakly	weakly	RB
10_1101-2020_09_09_289074	148	19	affect	affect	VB
10_1101-2020_09_09_289074	148	20	the	the	DT
10_1101-2020_09_09_289074	148	21	interaction	interaction	NN
10_1101-2020_09_09_289074	148	22	with	with	IN
10_1101-2020_09_09_289074	148	23	the	the	DT
10_1101-2020_09_09_289074	148	24	human	human	JJ
10_1101-2020_09_09_289074	148	25	receptor	receptor	NN
10_1101-2020_09_09_289074	148	26	,	,	,
10_1101-2020_09_09_289074	148	27	specifically	specifically	RB
10_1101-2020_09_09_289074	148	28	Spike	Spike	NNP
10_1101-2020_09_09_289074	148	29	N439	N439	NNP
10_1101-2020_09_09_289074	148	30	K	K	NNP
10_1101-2020_09_09_289074	148	31	,	,	,
10_1101-2020_09_09_289074	148	32	S477N	S477N	NNP
10_1101-2020_09_09_289074	148	33	and	and	CC
10_1101-2020_09_09_289074	148	34	N501Y.	N501Y.	NNP
10_1101-2020_09_09_289074	149	1	These	these	DT
10_1101-2020_09_09_289074	149	2	mutations	mutation	NNS
10_1101-2020_09_09_289074	149	3	are	be	VBP
10_1101-2020_09_09_289074	149	4	rising	rise	VBG
10_1101-2020_09_09_289074	149	5	in	in	IN
10_1101-2020_09_09_289074	149	6	the	the	DT
10_1101-2020_09_09_289074	149	7	viral	viral	JJ
10_1101-2020_09_09_289074	149	8	population	population	NN
10_1101-2020_09_09_289074	149	9	(	(	-LRB-
10_1101-2020_09_09_289074	149	10	>	>	NNP
10_1101-2020_09_09_289074	149	11	1	1	CD
10_1101-2020_09_09_289074	149	12	%	%	NN
10_1101-2020_09_09_289074	149	13	)	)	-RRB-
10_1101-2020_09_09_289074	149	14	and	and	CC
10_1101-2020_09_09_289074	149	15	in	in	IN
10_1101-2020_09_09_289074	149	16	particular	particular	JJ
10_1101-2020_09_09_289074	149	17	N501Y	n501y	CD
10_1101-2020_09_09_289074	149	18	is	be	VBZ
10_1101-2020_09_09_289074	149	19	one	one	CD
10_1101-2020_09_09_289074	149	20	of	of	IN
10_1101-2020_09_09_289074	149	21	the	the	DT
10_1101-2020_09_09_289074	149	22	key	key	JJ
10_1101-2020_09_09_289074	149	23	mutations	mutation	NNS
10_1101-2020_09_09_289074	149	24	characterizing	characterize	VBG
10_1101-2020_09_09_289074	149	25	lineage	lineage	NN
10_1101-2020_09_09_289074	149	26	B.1.1.7	B.1.1.7	NNP
10_1101-2020_09_09_289074	149	27	(	(	-LRB-
10_1101-2020_09_09_289074	149	28	32	32	CD
10_1101-2020_09_09_289074	149	29	)	)	-RRB-
10_1101-2020_09_09_289074	149	30	,	,	,
10_1101-2020_09_09_289074	149	31	which	which	WDT
10_1101-2020_09_09_289074	149	32	has	have	VBZ
10_1101-2020_09_09_289074	149	33	seen	see	VBN
10_1101-2020_09_09_289074	149	34	a	a	DT
10_1101-2020_09_09_289074	149	35	recent	recent	JJ
10_1101-2020_09_09_289074	149	36	dramatic	dramatic	JJ
10_1101-2020_09_09_289074	149	37	increase	increase	NN
10_1101-2020_09_09_289074	149	38	in	in	IN
10_1101-2020_09_09_289074	149	39	frequency	frequency	NN
10_1101-2020_09_09_289074	149	40	in	in	IN
10_1101-2020_09_09_289074	149	41	the	the	DT
10_1101-2020_09_09_289074	149	42	United	United	NNP
10_1101-2020_09_09_289074	149	43	Kingdom	Kingdom	NNP
10_1101-2020_09_09_289074	149	44	(	(	-LRB-
10_1101-2020_09_09_289074	149	45	30	30	CD
10_1101-2020_09_09_289074	149	46	)	)	-RRB-
10_1101-2020_09_09_289074	149	47	.	.	.
10_1101-2020_09_09_289074	150	1	Having	have	VBG
10_1101-2020_09_09_289074	150	2	identified	identify	VBN
10_1101-2020_09_09_289074	150	3	this	this	DT
10_1101-2020_09_09_289074	150	4	mutation	mutation	NN
10_1101-2020_09_09_289074	150	5	proves	prove	VBZ
10_1101-2020_09_09_289074	150	6	that	that	IN
10_1101-2020_09_09_289074	150	7	our	-PRON-	PRP$
10_1101-2020_09_09_289074	150	8	combination	combination	NN
10_1101-2020_09_09_289074	150	9	of	of	IN
10_1101-2020_09_09_289074	150	10	targeted	target	VBN
10_1101-2020_09_09_289074	150	11	mutation	mutation	NN
10_1101-2020_09_09_289074	150	12	frequency	frequency	NN
10_1101-2020_09_09_289074	150	13	and	and	CC
10_1101-2020_09_09_289074	150	14	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	150	15	is	be	VBZ
10_1101-2020_09_09_289074	150	16	a	a	DT
10_1101-2020_09_09_289074	150	17	useful	useful	JJ
10_1101-2020_09_09_289074	150	18	pipeline	pipeline	NN
10_1101-2020_09_09_289074	150	19	to	to	TO
10_1101-2020_09_09_289074	150	20	monitor	monitor	VB
10_1101-2020_09_09_289074	150	21	events	event	NNS
10_1101-2020_09_09_289074	150	22	in	in	IN
10_1101-2020_09_09_289074	150	23	the	the	DT
10_1101-2020_09_09_289074	150	24	key	key	JJ
10_1101-2020_09_09_289074	150	25	region	region	NN
10_1101-2020_09_09_289074	150	26	used	use	VBN
10_1101-2020_09_09_289074	150	27	by	by	IN
10_1101-2020_09_09_289074	150	28	SARS	SARS	NNP
10_1101-2020_09_09_289074	150	29	-	-	HYPH
10_1101-2020_09_09_289074	150	30	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	150	31	to	to	TO
10_1101-2020_09_09_289074	150	32	recognize	recognize	VB
10_1101-2020_09_09_289074	150	33	and	and	CC
10_1101-2020_09_09_289074	150	34	enter	enter	VB
10_1101-2020_09_09_289074	150	35	human	human	JJ
10_1101-2020_09_09_289074	150	36	bronchial	bronchial	JJ
10_1101-2020_09_09_289074	150	37	cells	cell	NNS
10_1101-2020_09_09_289074	150	38	.	.	.
10_1101-2020_09_09_289074	151	1	The	the	DT
10_1101-2020_09_09_289074	151	2	same	same	JJ
10_1101-2020_09_09_289074	151	3	approach	approach	NN
10_1101-2020_09_09_289074	151	4	can	can	MD
10_1101-2020_09_09_289074	151	5	be	be	VB
10_1101-2020_09_09_289074	151	6	used	use	VBN
10_1101-2020_09_09_289074	151	7	to	to	TO
10_1101-2020_09_09_289074	151	8	monitor	monitor	VB
10_1101-2020_09_09_289074	151	9	,	,	,
10_1101-2020_09_09_289074	151	10	in	in	IN
10_1101-2020_09_09_289074	151	11	the	the	DT
10_1101-2020_09_09_289074	151	12	future	future	NN
10_1101-2020_09_09_289074	151	13	,	,	,
10_1101-2020_09_09_289074	151	14	if	if	IN
10_1101-2020_09_09_289074	151	15	any	any	DT
10_1101-2020_09_09_289074	151	16	of	of	IN
10_1101-2020_09_09_289074	151	17	these	these	DT
10_1101-2020_09_09_289074	151	18	events	event	NNS
10_1101-2020_09_09_289074	151	19	will	will	MD
10_1101-2020_09_09_289074	151	20	increase	increase	VB
10_1101-2020_09_09_289074	151	21	in	in	IN
10_1101-2020_09_09_289074	151	22	frequency	frequency	NN
10_1101-2020_09_09_289074	151	23	,	,	,
10_1101-2020_09_09_289074	151	24	suggesting	suggest	VBG
10_1101-2020_09_09_289074	151	25	an	an	DT
10_1101-2020_09_09_289074	151	26	adaptation	adaptation	NN
10_1101-2020_09_09_289074	151	27	to	to	IN
10_1101-2020_09_09_289074	151	28	the	the	DT
10_1101-2020_09_09_289074	151	29	human	human	JJ
10_1101-2020_09_09_289074	151	30	host	host	NN
10_1101-2020_09_09_289074	151	31	leveraging	leverage	VBG
10_1101-2020_09_09_289074	151	32	a	a	DT
10_1101-2020_09_09_289074	151	33	higher	high	JJR
10_1101-2020_09_09_289074	151	34	affinity	affinity	NN
10_1101-2020_09_09_289074	151	35	with	with	IN
10_1101-2020_09_09_289074	151	36	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	151	37	.	.	.
10_1101-2020_09_09_289074	152	1	On	on	IN
10_1101-2020_09_09_289074	152	2	the	the	DT
10_1101-2020_09_09_289074	152	3	other	other	JJ
10_1101-2020_09_09_289074	152	4	hand	hand	NN
10_1101-2020_09_09_289074	152	5	,	,	,
10_1101-2020_09_09_289074	152	6	we	-PRON-	PRP
10_1101-2020_09_09_289074	152	7	studied	study	VBD
10_1101-2020_09_09_289074	152	8	the	the	DT
10_1101-2020_09_09_289074	152	9	variants	variant	NNS
10_1101-2020_09_09_289074	152	10	in	in	IN
10_1101-2020_09_09_289074	152	11	the	the	DT
10_1101-2020_09_09_289074	152	12	human	human	JJ
10_1101-2020_09_09_289074	152	13	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	152	14	population	population	NN
10_1101-2020_09_09_289074	152	15	,	,	,
10_1101-2020_09_09_289074	152	16	identifying	identify	VBG
10_1101-2020_09_09_289074	152	17	5	5	CD
10_1101-2020_09_09_289074	152	18	loci	loci	NN
10_1101-2020_09_09_289074	152	19	that	that	WDT
10_1101-2020_09_09_289074	152	20	can	can	MD
10_1101-2020_09_09_289074	152	21	affect	affect	VB
10_1101-2020_09_09_289074	152	22	the	the	DT
10_1101-2020_09_09_289074	152	23	binding	binding	NN
10_1101-2020_09_09_289074	152	24	with	with	IN
10_1101-2020_09_09_289074	152	25	SARS	SARS	NNP
10_1101-2020_09_09_289074	152	26	-	-	HYPH
10_1101-2020_09_09_289074	152	27	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	152	28	Spike	Spike	NNP
10_1101-2020_09_09_289074	152	29	.	.	.
10_1101-2020_09_09_289074	153	1	They	-PRON-	PRP
10_1101-2020_09_09_289074	153	2	are	be	VBP
10_1101-2020_09_09_289074	153	3	all	all	RB
10_1101-2020_09_09_289074	153	4	rare	rare	JJ
10_1101-2020_09_09_289074	153	5	variants	variant	NNS
10_1101-2020_09_09_289074	153	6	,	,	,
10_1101-2020_09_09_289074	153	7	with	with	IN
10_1101-2020_09_09_289074	153	8	the	the	DT
10_1101-2020_09_09_289074	153	9	most	most	RBS
10_1101-2020_09_09_289074	153	10	frequent	frequent	JJ
10_1101-2020_09_09_289074	153	11	,	,	,
10_1101-2020_09_09_289074	153	12	S19P	s19p	NN
10_1101-2020_09_09_289074	153	13	,	,	,
10_1101-2020_09_09_289074	153	14	present	present	JJ
10_1101-2020_09_09_289074	153	15	in	in	IN
10_1101-2020_09_09_289074	153	16	0.06	0.06	CD
10_1101-2020_09_09_289074	153	17	%	%	NN
10_1101-2020_09_09_289074	153	18	of	of	IN
10_1101-2020_09_09_289074	153	19	the	the	DT
10_1101-2020_09_09_289074	153	20	population	population	NN
10_1101-2020_09_09_289074	153	21	,	,	,
10_1101-2020_09_09_289074	153	22	and	and	CC
10_1101-2020_09_09_289074	153	23	with	with	IN
10_1101-2020_09_09_289074	153	24	no	no	DT
10_1101-2020_09_09_289074	153	25	known	know	VBN
10_1101-2020_09_09_289074	153	26	clinical	clinical	JJ
10_1101-2020_09_09_289074	153	27	significance	significance	NN
10_1101-2020_09_09_289074	153	28	.	.	.
10_1101-2020_09_09_289074	154	1	However	however	RB
10_1101-2020_09_09_289074	154	2	,	,	,
10_1101-2020_09_09_289074	154	3	other	other	JJ
10_1101-2020_09_09_289074	154	4	in	in	IN
10_1101-2020_09_09_289074	154	5	silico	silico	NNS
10_1101-2020_09_09_289074	154	6	studies	study	NNS
10_1101-2020_09_09_289074	154	7	have	have	VBP
10_1101-2020_09_09_289074	154	8	predicted	predict	VBN
10_1101-2020_09_09_289074	154	9	their	-PRON-	PRP$
10_1101-2020_09_09_289074	154	10	role	role	NN
10_1101-2020_09_09_289074	154	11	in	in	IN
10_1101-2020_09_09_289074	154	12	decreasing	decrease	VBG
10_1101-2020_09_09_289074	154	13	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	154	14	stability	stability	NN
10_1101-2020_09_09_289074	154	15	(	(	-LRB-
10_1101-2020_09_09_289074	154	16	S19P	s19p	NN
10_1101-2020_09_09_289074	154	17	and	and	CC
10_1101-2020_09_09_289074	154	18	M82I	M82I	NNP
10_1101-2020_09_09_289074	154	19	)	)	-RRB-
10_1101-2020_09_09_289074	154	20	(	(	-LRB-
10_1101-2020_09_09_289074	154	21	36	36	CD
10_1101-2020_09_09_289074	154	22	)	)	-RRB-
10_1101-2020_09_09_289074	154	23	,	,	,
10_1101-2020_09_09_289074	154	24	and	and	CC
10_1101-2020_09_09_289074	154	25	in	in	IN
10_1101-2020_09_09_289074	154	26	altering	alter	VBG
10_1101-2020_09_09_289074	154	27	the	the	DT
10_1101-2020_09_09_289074	154	28	affinity	affinity	NN
10_1101-2020_09_09_289074	154	29	with	with	IN
10_1101-2020_09_09_289074	154	30	Spike	Spike	NNP
10_1101-2020_09_09_289074	154	31	(	(	-LRB-
10_1101-2020_09_09_289074	154	32	increasing	increase	VBG
10_1101-2020_09_09_289074	154	33	it	-PRON-	PRP
10_1101-2020_09_09_289074	154	34	:	:	:
10_1101-2020_09_09_289074	154	35	M82I	M82I	NNP
10_1101-2020_09_09_289074	154	36	and	and	CC
10_1101-2020_09_09_289074	154	37	E329	e329	UH
10_1101-2020_09_09_289074	154	38	G	G	NNP
10_1101-2020_09_09_289074	154	39	(	(	-LRB-
10_1101-2020_09_09_289074	154	40	37	37	CD
10_1101-2020_09_09_289074	154	41	)	)	-RRB-
10_1101-2020_09_09_289074	154	42	;	;	:
10_1101-2020_09_09_289074	154	43	decreasing	decrease	VBG
10_1101-2020_09_09_289074	154	44	it	-PRON-	PRP
10_1101-2020_09_09_289074	154	45	:	:	:
10_1101-2020_09_09_289074	154	46	E37	E37	NNP
10_1101-2020_09_09_289074	154	47	K	K	NNP
10_1101-2020_09_09_289074	154	48	(	(	-LRB-
10_1101-2020_09_09_289074	154	49	37	37	CD
10_1101-2020_09_09_289074	154	50	)	)	-RRB-
10_1101-2020_09_09_289074	154	51	and	and	CC
10_1101-2020_09_09_289074	154	52	G352V	g352v	CD
10_1101-2020_09_09_289074	154	53	(	(	-LRB-
10_1101-2020_09_09_289074	154	54	38	38	CD
10_1101-2020_09_09_289074	154	55	)	)	-RRB-
10_1101-2020_09_09_289074	154	56	)	)	-RRB-
10_1101-2020_09_09_289074	154	57	.	.	.
10_1101-2020_09_09_289074	155	1	The	the	DT
10_1101-2020_09_09_289074	155	2	most	most	RBS
10_1101-2020_09_09_289074	155	3	common	common	JJ
10_1101-2020_09_09_289074	155	4	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	155	5	variant	variant	NN
10_1101-2020_09_09_289074	155	6	,	,	,
10_1101-2020_09_09_289074	155	7	rs41303171	rs41303171	FW
10_1101-2020_09_09_289074	155	8	(	(	-LRB-
10_1101-2020_09_09_289074	155	9	N720D	N720D	NNP
10_1101-2020_09_09_289074	155	10	)	)	-RRB-
10_1101-2020_09_09_289074	155	11	,	,	,
10_1101-2020_09_09_289074	155	12	is	be	VBZ
10_1101-2020_09_09_289074	155	13	not	not	RB
10_1101-2020_09_09_289074	155	14	located	locate	VBN
10_1101-2020_09_09_289074	155	15	in	in	IN
10_1101-2020_09_09_289074	155	16	the	the	DT
10_1101-2020_09_09_289074	155	17	binding	bind	VBG
10_1101-2020_09_09_289074	155	18	region	region	NN
10_1101-2020_09_09_289074	155	19	,	,	,
10_1101-2020_09_09_289074	155	20	and	and	CC
10_1101-2020_09_09_289074	155	21	so	so	RB
10_1101-2020_09_09_289074	155	22	far	far	RB
10_1101-2020_09_09_289074	155	23	its	-PRON-	PRP$
10_1101-2020_09_09_289074	155	24	predicted	predict	VBN
10_1101-2020_09_09_289074	155	25	effects	effect	NNS
10_1101-2020_09_09_289074	155	26	on	on	IN
10_1101-2020_09_09_289074	155	27	the	the	DT
10_1101-2020_09_09_289074	155	28	etiopathology	etiopathology	NN
10_1101-2020_09_09_289074	155	29	of	of	IN
10_1101-2020_09_09_289074	155	30	COVID-19	COVID-19	,
10_1101-2020_09_09_289074	155	31	are	be	VBP
10_1101-2020_09_09_289074	155	32	still	still	RB
10_1101-2020_09_09_289074	155	33	largely	largely	RB
10_1101-2020_09_09_289074	155	34	conjectural	conjectural	JJ
10_1101-2020_09_09_289074	155	35	and	and	CC
10_1101-2020_09_09_289074	155	36	associated	associate	VBN
10_1101-2020_09_09_289074	155	37	to	to	IN
10_1101-2020_09_09_289074	155	38	neurological	neurological	JJ
10_1101-2020_09_09_289074	155	39	complications	complication	NNS
10_1101-2020_09_09_289074	155	40	via	via	IN
10_1101-2020_09_09_289074	155	41	mechanisms	mechanism	NNS
10_1101-2020_09_09_289074	155	42	probably	probably	RB
10_1101-2020_09_09_289074	155	43	independent	independent	JJ
10_1101-2020_09_09_289074	155	44	from	from	IN
10_1101-2020_09_09_289074	155	45	direct	direct	JJ
10_1101-2020_09_09_289074	155	46	interaction	interaction	NN
10_1101-2020_09_09_289074	155	47	with	with	IN
10_1101-2020_09_09_289074	155	48	Spike	Spike	NNP
10_1101-2020_09_09_289074	155	49	(	(	-LRB-
10_1101-2020_09_09_289074	155	50	41	41	CD
10_1101-2020_09_09_289074	155	51	)	)	-RRB-
10_1101-2020_09_09_289074	155	52	.	.	.
10_1101-2020_09_09_289074	156	1	.CC	.CC	NFP
10_1101-2020_09_09_289074	156	2	-	-	:
10_1101-2020_09_09_289074	156	3	BY	by	IN
10_1101-2020_09_09_289074	156	4	-	-	HYPH
10_1101-2020_09_09_289074	156	5	NC	NC	NNP
10_1101-2020_09_09_289074	156	6	-	-	HYPH
10_1101-2020_09_09_289074	156	7	ND	ND	NNP
10_1101-2020_09_09_289074	156	8	4.0	4.0	CD
10_1101-2020_09_09_289074	156	9	International	International	NNP
10_1101-2020_09_09_289074	156	10	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	156	11	under	under	IN
10_1101-2020_09_09_289074	156	12	a	a	DT
10_1101-2020_09_09_289074	156	13	(	(	-LRB-
10_1101-2020_09_09_289074	156	14	which	which	WDT
10_1101-2020_09_09_289074	156	15	was	be	VBD
10_1101-2020_09_09_289074	156	16	not	not	RB
10_1101-2020_09_09_289074	156	17	certified	certify	VBN
10_1101-2020_09_09_289074	156	18	by	by	IN
10_1101-2020_09_09_289074	156	19	peer	peer	NN
10_1101-2020_09_09_289074	156	20	review	review	NN
10_1101-2020_09_09_289074	156	21	)	)	-RRB-
10_1101-2020_09_09_289074	156	22	is	be	VBZ
10_1101-2020_09_09_289074	156	23	the	the	DT
10_1101-2020_09_09_289074	156	24	author	author	NN
10_1101-2020_09_09_289074	156	25	/	/	SYM
10_1101-2020_09_09_289074	156	26	funder	funder	NN
10_1101-2020_09_09_289074	156	27	,	,	,
10_1101-2020_09_09_289074	156	28	who	who	WP
10_1101-2020_09_09_289074	156	29	has	have	VBZ
10_1101-2020_09_09_289074	156	30	granted	grant	VBN
10_1101-2020_09_09_289074	156	31	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	156	32	a	a	DT
10_1101-2020_09_09_289074	156	33	license	license	NN
10_1101-2020_09_09_289074	156	34	to	to	TO
10_1101-2020_09_09_289074	156	35	display	display	VB
10_1101-2020_09_09_289074	156	36	the	the	DT
10_1101-2020_09_09_289074	156	37	preprint	preprint	NN
10_1101-2020_09_09_289074	156	38	in	in	IN
10_1101-2020_09_09_289074	156	39	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	156	40	.	.	.
10_1101-2020_09_09_289074	157	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	157	2	is	be	VBZ
10_1101-2020_09_09_289074	157	3	made	make	VBN
10_1101-2020_09_09_289074	157	4	The	the	DT
10_1101-2020_09_09_289074	157	5	copyright	copyright	NN
10_1101-2020_09_09_289074	157	6	holder	holder	NN
10_1101-2020_09_09_289074	157	7	for	for	IN
10_1101-2020_09_09_289074	157	8	this	this	DT
10_1101-2020_09_09_289074	157	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	157	10	version	version	NN
10_1101-2020_09_09_289074	157	11	posted	post	VBD
10_1101-2020_09_09_289074	157	12	January	January	NNP
10_1101-2020_09_09_289074	157	13	5	5	CD
10_1101-2020_09_09_289074	157	14	,	,	,
10_1101-2020_09_09_289074	157	15	2021	2021	CD
10_1101-2020_09_09_289074	157	16	.	.	.
10_1101-2020_09_09_289074	157	17	;	;	:
10_1101-2020_09_09_289074	157	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	157	19	:	:	:
10_1101-2020_09_09_289074	157	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	157	21	preprint	preprint	NN
10_1101-2020_09_09_289074	157	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	157	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	RB
10_1101-2020_09_09_289074	157	24	9	9	CD
10_1101-2020_09_09_289074	157	25	It	-PRON-	PRP
10_1101-2020_09_09_289074	157	26	remains	remain	VBZ
10_1101-2020_09_09_289074	157	27	to	to	TO
10_1101-2020_09_09_289074	157	28	be	be	VB
10_1101-2020_09_09_289074	157	29	seen	see	VBN
10_1101-2020_09_09_289074	157	30	whether	whether	IN
10_1101-2020_09_09_289074	157	31	,	,	,
10_1101-2020_09_09_289074	157	32	in	in	IN
10_1101-2020_09_09_289074	157	33	the	the	DT
10_1101-2020_09_09_289074	157	34	future	future	NN
10_1101-2020_09_09_289074	157	35	,	,	,
10_1101-2020_09_09_289074	157	36	the	the	DT
10_1101-2020_09_09_289074	157	37	combination	combination	NN
10_1101-2020_09_09_289074	157	38	of	of	IN
10_1101-2020_09_09_289074	157	39	Spike	Spike	NNP
10_1101-2020_09_09_289074	157	40	and	and	CC
10_1101-2020_09_09_289074	157	41	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	157	42	sequences	sequence	NNS
10_1101-2020_09_09_289074	157	43	will	will	MD
10_1101-2020_09_09_289074	157	44	produce	produce	VB
10_1101-2020_09_09_289074	157	45	novel	novel	JJ
10_1101-2020_09_09_289074	157	46	and	and	CC
10_1101-2020_09_09_289074	157	47	unexpected	unexpected	JJ
10_1101-2020_09_09_289074	157	48	COVID-19	covid-19	JJ
10_1101-2020_09_09_289074	157	49	specificities	specificity	NNS
10_1101-2020_09_09_289074	157	50	,	,	,
10_1101-2020_09_09_289074	157	51	that	that	WDT
10_1101-2020_09_09_289074	157	52	will	will	MD
10_1101-2020_09_09_289074	157	53	require	require	VB
10_1101-2020_09_09_289074	157	54	granular	granular	JJ
10_1101-2020_09_09_289074	157	55	efforts	effort	NNS
10_1101-2020_09_09_289074	157	56	in	in	IN
10_1101-2020_09_09_289074	157	57	developing	develop	VBG
10_1101-2020_09_09_289074	157	58	wider	wide	JJR
10_1101-2020_09_09_289074	157	59	-	-	HYPH
10_1101-2020_09_09_289074	157	60	spectrum	spectrum	NN
10_1101-2020_09_09_289074	157	61	anti	anti	JJ
10_1101-2020_09_09_289074	157	62	-	-	JJ
10_1101-2020_09_09_289074	157	63	SARS	sars	JJ
10_1101-2020_09_09_289074	157	64	-	-	HYPH
10_1101-2020_09_09_289074	157	65	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	157	66	strategies	strategy	NNS
10_1101-2020_09_09_289074	157	67	,	,	,
10_1101-2020_09_09_289074	157	68	such	such	JJ
10_1101-2020_09_09_289074	157	69	as	as	IN
10_1101-2020_09_09_289074	157	70	vaccines	vaccine	NNS
10_1101-2020_09_09_289074	157	71	or	or	CC
10_1101-2020_09_09_289074	157	72	antiviral	antiviral	JJ
10_1101-2020_09_09_289074	157	73	drugs	drug	NNS
10_1101-2020_09_09_289074	157	74	.	.	.
10_1101-2020_09_09_289074	158	1	So	so	RB
10_1101-2020_09_09_289074	158	2	far	far	RB
10_1101-2020_09_09_289074	158	3	,	,	,
10_1101-2020_09_09_289074	158	4	our	-PRON-	PRP$
10_1101-2020_09_09_289074	158	5	analysis	analysis	NN
10_1101-2020_09_09_289074	158	6	has	have	VBZ
10_1101-2020_09_09_289074	158	7	shown	show	VBN
10_1101-2020_09_09_289074	158	8	a	a	DT
10_1101-2020_09_09_289074	158	9	location	location	NN
10_1101-2020_09_09_289074	158	10	on	on	IN
10_1101-2020_09_09_289074	158	11	the	the	DT
10_1101-2020_09_09_289074	158	12	Spike	Spike	NNP
10_1101-2020_09_09_289074	158	13	/	/	SYM
10_1101-2020_09_09_289074	158	14	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	158	15	complex	complex	NN
10_1101-2020_09_09_289074	158	16	where	where	WRB
10_1101-2020_09_09_289074	158	17	both	both	DT
10_1101-2020_09_09_289074	158	18	proteins	protein	NNS
10_1101-2020_09_09_289074	158	19	vary	vary	VBP
10_1101-2020_09_09_289074	158	20	in	in	IN
10_1101-2020_09_09_289074	158	21	the	the	DT
10_1101-2020_09_09_289074	158	22	viral	viral	NNP
10_1101-2020_09_09_289074	158	23	/	/	SYM
10_1101-2020_09_09_289074	158	24	human	human	JJ
10_1101-2020_09_09_289074	158	25	population	population	NN
10_1101-2020_09_09_289074	158	26	,	,	,
10_1101-2020_09_09_289074	158	27	specifically	specifically	RB
10_1101-2020_09_09_289074	158	28	on	on	IN
10_1101-2020_09_09_289074	158	29	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	158	30	S19	S19	NNP
10_1101-2020_09_09_289074	158	31	and	and	CC
10_1101-2020_09_09_289074	158	32	Spike	Spike	NNP
10_1101-2020_09_09_289074	158	33	A475	A475	NNP
10_1101-2020_09_09_289074	158	34	/	/	SYM
10_1101-2020_09_09_289074	158	35	G476	G476	NNP
10_1101-2020_09_09_289074	158	36	.	.	.
10_1101-2020_09_09_289074	159	1	While	while	IN
10_1101-2020_09_09_289074	159	2	,	,	,
10_1101-2020_09_09_289074	159	3	as	as	IN
10_1101-2020_09_09_289074	159	4	described	describe	VBN
10_1101-2020_09_09_289074	159	5	in	in	IN
10_1101-2020_09_09_289074	159	6	our	-PRON-	PRP$
10_1101-2020_09_09_289074	159	7	Results	result	NNS
10_1101-2020_09_09_289074	159	8	,	,	,
10_1101-2020_09_09_289074	159	9	these	these	DT
10_1101-2020_09_09_289074	159	10	mutations	mutation	NNS
10_1101-2020_09_09_289074	159	11	on	on	IN
10_1101-2020_09_09_289074	159	12	Spike	Spike	NNP
10_1101-2020_09_09_289074	159	13	are	be	VBP
10_1101-2020_09_09_289074	159	14	not	not	RB
10_1101-2020_09_09_289074	159	15	likely	likely	JJ
10_1101-2020_09_09_289074	159	16	to	to	TO
10_1101-2020_09_09_289074	159	17	strongly	strongly	RB
10_1101-2020_09_09_289074	159	18	affect	affect	VB
10_1101-2020_09_09_289074	159	19	the	the	DT
10_1101-2020_09_09_289074	159	20	interaction	interaction	NN
10_1101-2020_09_09_289074	159	21	surface	surface	NN
10_1101-2020_09_09_289074	159	22	,	,	,
10_1101-2020_09_09_289074	159	23	future	future	JJ
10_1101-2020_09_09_289074	159	24	combinations	combination	NNS
10_1101-2020_09_09_289074	159	25	of	of	IN
10_1101-2020_09_09_289074	159	26	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	159	27	/	/	SYM
10_1101-2020_09_09_289074	159	28	Spike	Spike	NNP
10_1101-2020_09_09_289074	159	29	variants	variant	NNS
10_1101-2020_09_09_289074	159	30	may	may	MD
10_1101-2020_09_09_289074	159	31	have	have	VB
10_1101-2020_09_09_289074	159	32	peculiar	peculiar	JJ
10_1101-2020_09_09_289074	159	33	effects	effect	NNS
10_1101-2020_09_09_289074	159	34	that	that	WDT
10_1101-2020_09_09_289074	159	35	will	will	MD
10_1101-2020_09_09_289074	159	36	require	require	VB
10_1101-2020_09_09_289074	159	37	constant	constant	JJ
10_1101-2020_09_09_289074	159	38	mutation	mutation	NN
10_1101-2020_09_09_289074	159	39	monitoring	monitoring	NN
10_1101-2020_09_09_289074	159	40	.	.	.
10_1101-2020_09_09_289074	160	1	Identifying	identify	VBG
10_1101-2020_09_09_289074	160	2	single	single	JJ
10_1101-2020_09_09_289074	160	3	or	or	CC
10_1101-2020_09_09_289074	160	4	multiple	multiple	JJ
10_1101-2020_09_09_289074	160	5	AAs	aa	NNS
10_1101-2020_09_09_289074	160	6	involved	involve	VBN
10_1101-2020_09_09_289074	160	7	in	in	IN
10_1101-2020_09_09_289074	160	8	this	this	DT
10_1101-2020_09_09_289074	160	9	viral	viral	JJ
10_1101-2020_09_09_289074	160	10	entry	entry	NN
10_1101-2020_09_09_289074	160	11	interaction	interaction	NN
10_1101-2020_09_09_289074	160	12	will	will	MD
10_1101-2020_09_09_289074	160	13	allow	allow	VB
10_1101-2020_09_09_289074	160	14	for	for	IN
10_1101-2020_09_09_289074	160	15	personalized	personalized	JJ
10_1101-2020_09_09_289074	160	16	diagnosis	diagnosis	NN
10_1101-2020_09_09_289074	160	17	and	and	CC
10_1101-2020_09_09_289074	160	18	clinical	clinical	JJ
10_1101-2020_09_09_289074	160	19	prediction	prediction	NN
10_1101-2020_09_09_289074	160	20	based	base	VBN
10_1101-2020_09_09_289074	160	21	on	on	IN
10_1101-2020_09_09_289074	160	22	the	the	DT
10_1101-2020_09_09_289074	160	23	specific	specific	JJ
10_1101-2020_09_09_289074	160	24	combination	combination	NN
10_1101-2020_09_09_289074	160	25	of	of	IN
10_1101-2020_09_09_289074	160	26	SARS	SARS	NNP
10_1101-2020_09_09_289074	160	27	-	-	HYPH
10_1101-2020_09_09_289074	160	28	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	160	29	strain	strain	NN
10_1101-2020_09_09_289074	160	30	and	and	CC
10_1101-2020_09_09_289074	160	31	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	160	32	variant	variant	JJ
10_1101-2020_09_09_289074	160	33	.	.	.
10_1101-2020_09_09_289074	161	1	Personalized	personalize	VBN
10_1101-2020_09_09_289074	161	2	COVID-19	covid-19	NN
10_1101-2020_09_09_289074	161	3	treatment	treatment	NN
10_1101-2020_09_09_289074	161	4	will	will	MD
10_1101-2020_09_09_289074	161	5	require	require	VB
10_1101-2020_09_09_289074	161	6	targeted	target	VBN
10_1101-2020_09_09_289074	161	7	sequencing	sequencing	NN
10_1101-2020_09_09_289074	161	8	of	of	IN
10_1101-2020_09_09_289074	161	9	the	the	DT
10_1101-2020_09_09_289074	161	10	patient	patient	NN
10_1101-2020_09_09_289074	161	11	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	161	12	and	and	CC
10_1101-2020_09_09_289074	161	13	Spike	Spike	NNP
10_1101-2020_09_09_289074	161	14	,	,	,
10_1101-2020_09_09_289074	161	15	to	to	TO
10_1101-2020_09_09_289074	161	16	identify	identify	VB
10_1101-2020_09_09_289074	161	17	the	the	DT
10_1101-2020_09_09_289074	161	18	combination	combination	NN
10_1101-2020_09_09_289074	161	19	causing	cause	VBG
10_1101-2020_09_09_289074	161	20	the	the	DT
10_1101-2020_09_09_289074	161	21	specific	specific	JJ
10_1101-2020_09_09_289074	161	22	case	case	NN
10_1101-2020_09_09_289074	161	23	.	.	.
10_1101-2020_09_09_289074	162	1	This	this	DT
10_1101-2020_09_09_289074	162	2	technical	technical	JJ
10_1101-2020_09_09_289074	162	3	obstacle	obstacle	NN
10_1101-2020_09_09_289074	162	4	can	can	MD
10_1101-2020_09_09_289074	162	5	be	be	VB
10_1101-2020_09_09_289074	162	6	further	further	RB
10_1101-2020_09_09_289074	162	7	complicated	complicate	VBN
10_1101-2020_09_09_289074	162	8	by	by	IN
10_1101-2020_09_09_289074	162	9	the	the	DT
10_1101-2020_09_09_289074	162	10	intra	intra	JJ
10_1101-2020_09_09_289074	162	11	-	-	JJ
10_1101-2020_09_09_289074	162	12	host	host	JJ
10_1101-2020_09_09_289074	162	13	genetic	genetic	JJ
10_1101-2020_09_09_289074	162	14	variability	variability	NN
10_1101-2020_09_09_289074	162	15	of	of	IN
10_1101-2020_09_09_289074	162	16	SARS	SARS	NNP
10_1101-2020_09_09_289074	162	17	-	-	HYPH
10_1101-2020_09_09_289074	162	18	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	162	19	,	,	,
10_1101-2020_09_09_289074	162	20	which	which	WDT
10_1101-2020_09_09_289074	162	21	has	have	VBZ
10_1101-2020_09_09_289074	162	22	recently	recently	RB
10_1101-2020_09_09_289074	162	23	been	be	VBN
10_1101-2020_09_09_289074	162	24	reported	report	VBN
10_1101-2020_09_09_289074	162	25	from	from	IN
10_1101-2020_09_09_289074	162	26	RNA	RNA	NNP
10_1101-2020_09_09_289074	162	27	-	-	HYPH
10_1101-2020_09_09_289074	162	28	Sequencing	Sequencing	NNP
10_1101-2020_09_09_289074	162	29	studies	study	NNS
10_1101-2020_09_09_289074	162	30	(	(	-LRB-
10_1101-2020_09_09_289074	162	31	42	42	CD
10_1101-2020_09_09_289074	162	32	)	)	-RRB-
10_1101-2020_09_09_289074	162	33	.	.	.
10_1101-2020_09_09_289074	163	1	Structural	structural	JJ
10_1101-2020_09_09_289074	163	2	investigation	investigation	NN
10_1101-2020_09_09_289074	163	3	will	will	MD
10_1101-2020_09_09_289074	163	4	benefit	benefit	VB
10_1101-2020_09_09_289074	163	5	,	,	,
10_1101-2020_09_09_289074	163	6	in	in	IN
10_1101-2020_09_09_289074	163	7	the	the	DT
10_1101-2020_09_09_289074	163	8	next	next	JJ
10_1101-2020_09_09_289074	163	9	future	future	NN
10_1101-2020_09_09_289074	163	10	,	,	,
10_1101-2020_09_09_289074	163	11	from	from	IN
10_1101-2020_09_09_289074	163	12	the	the	DT
10_1101-2020_09_09_289074	163	13	availability	availability	NN
10_1101-2020_09_09_289074	163	14	of	of	IN
10_1101-2020_09_09_289074	163	15	experimental	experimental	JJ
10_1101-2020_09_09_289074	163	16	structural	structural	JJ
10_1101-2020_09_09_289074	163	17	models	model	NNS
10_1101-2020_09_09_289074	163	18	reporting	report	VBG
10_1101-2020_09_09_289074	163	19	the	the	DT
10_1101-2020_09_09_289074	163	20	complete	complete	JJ
10_1101-2020_09_09_289074	163	21	sequence	sequence	NN
10_1101-2020_09_09_289074	163	22	of	of	IN
10_1101-2020_09_09_289074	163	23	both	both	CC
10_1101-2020_09_09_289074	163	24	Spike	Spike	NNP
10_1101-2020_09_09_289074	163	25	and	and	CC
10_1101-2020_09_09_289074	163	26	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	163	27	,	,	,
10_1101-2020_09_09_289074	163	28	or	or	CC
10_1101-2020_09_09_289074	163	29	at	at	IN
10_1101-2020_09_09_289074	163	30	least	least	JJS
10_1101-2020_09_09_289074	163	31	Spike	spike	JJ
10_1101-2020_09_09_289074	163	32	.	.	.
10_1101-2020_09_09_289074	164	1	This	this	DT
10_1101-2020_09_09_289074	164	2	will	will	MD
10_1101-2020_09_09_289074	164	3	allow	allow	VB
10_1101-2020_09_09_289074	164	4	more	more	RBR
10_1101-2020_09_09_289074	164	5	rigorous	rigorous	JJ
10_1101-2020_09_09_289074	164	6	computational	computational	JJ
10_1101-2020_09_09_289074	164	7	analyses	analysis	NNS
10_1101-2020_09_09_289074	164	8	(	(	-LRB-
10_1101-2020_09_09_289074	164	9	i.e.	i.e.	FW
10_1101-2020_09_09_289074	165	1	molecular	molecular	JJ
10_1101-2020_09_09_289074	165	2	dynamics	dynamic	NNS
10_1101-2020_09_09_289074	165	3	simulation	simulation	NN
10_1101-2020_09_09_289074	165	4	,	,	,
10_1101-2020_09_09_289074	165	5	free	free	JJ
10_1101-2020_09_09_289074	165	6	energy	energy	NN
10_1101-2020_09_09_289074	165	7	perturbation	perturbation	NN
10_1101-2020_09_09_289074	165	8	)	)	-RRB-
10_1101-2020_09_09_289074	165	9	on	on	IN
10_1101-2020_09_09_289074	165	10	the	the	DT
10_1101-2020_09_09_289074	165	11	effect	effect	NN
10_1101-2020_09_09_289074	165	12	of	of	IN
10_1101-2020_09_09_289074	165	13	mutations	mutation	NNS
10_1101-2020_09_09_289074	165	14	on	on	IN
10_1101-2020_09_09_289074	165	15	the	the	DT
10_1101-2020_09_09_289074	165	16	Spike	Spike	NNP
10_1101-2020_09_09_289074	165	17	/	/	SYM
10_1101-2020_09_09_289074	165	18	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	165	19	recognition	recognition	NN
10_1101-2020_09_09_289074	165	20	.	.	.
10_1101-2020_09_09_289074	166	1	Beyond	beyond	IN
10_1101-2020_09_09_289074	166	2	the	the	DT
10_1101-2020_09_09_289074	166	3	complex	complex	NN
10_1101-2020_09_09_289074	166	4	investigated	investigate	VBN
10_1101-2020_09_09_289074	166	5	in	in	IN
10_1101-2020_09_09_289074	166	6	this	this	DT
10_1101-2020_09_09_289074	166	7	manuscript	manuscript	NN
10_1101-2020_09_09_289074	166	8	,	,	,
10_1101-2020_09_09_289074	166	9	our	-PRON-	PRP$
10_1101-2020_09_09_289074	166	10	approach	approach	NN
10_1101-2020_09_09_289074	166	11	can	can	MD
10_1101-2020_09_09_289074	166	12	be	be	VB
10_1101-2020_09_09_289074	166	13	fully	fully	RB
10_1101-2020_09_09_289074	166	14	extended	extend	VBN
10_1101-2020_09_09_289074	166	15	to	to	IN
10_1101-2020_09_09_289074	166	16	any	any	DT
10_1101-2020_09_09_289074	166	17	other	other	JJ
10_1101-2020_09_09_289074	166	18	partners	partner	NNS
10_1101-2020_09_09_289074	166	19	in	in	IN
10_1101-2020_09_09_289074	166	20	the	the	DT
10_1101-2020_09_09_289074	166	21	SARS	SARS	NNP
10_1101-2020_09_09_289074	166	22	-	-	HYPH
10_1101-2020_09_09_289074	166	23	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	166	24	/	/	SYM
10_1101-2020_09_09_289074	166	25	human	human	NN
10_1101-2020_09_09_289074	166	26	interactome	interactome	NN
10_1101-2020_09_09_289074	166	27	,	,	,
10_1101-2020_09_09_289074	166	28	for	for	IN
10_1101-2020_09_09_289074	166	29	example	example	NN
10_1101-2020_09_09_289074	166	30	the	the	DT
10_1101-2020_09_09_289074	166	31	recently	recently	RB
10_1101-2020_09_09_289074	166	32	discovered	discover	VBN
10_1101-2020_09_09_289074	166	33	interaction	interaction	NN
10_1101-2020_09_09_289074	166	34	between	between	IN
10_1101-2020_09_09_289074	166	35	viral	viral	JJ
10_1101-2020_09_09_289074	166	36	protease	protease	NN
10_1101-2020_09_09_289074	166	37	NSP5	NSP5	NNP
10_1101-2020_09_09_289074	166	38	(	(	-LRB-
10_1101-2020_09_09_289074	166	39	43	43	CD
10_1101-2020_09_09_289074	166	40	)	)	-RRB-
10_1101-2020_09_09_289074	166	41	and	and	CC
10_1101-2020_09_09_289074	166	42	human	human	JJ
10_1101-2020_09_09_289074	166	43	histone	histone	JJ
10_1101-2020_09_09_289074	166	44	deacetylase	deacetylase	NN
10_1101-2020_09_09_289074	166	45	HDAC2	HDAC2	NNP
10_1101-2020_09_09_289074	166	46	(	(	-LRB-
10_1101-2020_09_09_289074	166	47	44	44	CD
10_1101-2020_09_09_289074	166	48	)	)	-RRB-
10_1101-2020_09_09_289074	166	49	,	,	,
10_1101-2020_09_09_289074	166	50	which	which	WDT
10_1101-2020_09_09_289074	166	51	is	be	VBZ
10_1101-2020_09_09_289074	166	52	indirectly	indirectly	RB
10_1101-2020_09_09_289074	166	53	responsible	responsible	JJ
10_1101-2020_09_09_289074	166	54	for	for	IN
10_1101-2020_09_09_289074	166	55	the	the	DT
10_1101-2020_09_09_289074	166	56	transcriptional	transcriptional	JJ
10_1101-2020_09_09_289074	166	57	activation	activation	NN
10_1101-2020_09_09_289074	166	58	of	of	IN
10_1101-2020_09_09_289074	166	59	pro	pro	JJ
10_1101-2020_09_09_289074	166	60	-	-	JJ
10_1101-2020_09_09_289074	166	61	inflammatory	inflammatory	JJ
10_1101-2020_09_09_289074	166	62	genes	gene	NNS
10_1101-2020_09_09_289074	166	63	.	.	.
10_1101-2020_09_09_289074	167	1	Our	-PRON-	PRP$
10_1101-2020_09_09_289074	167	2	approach	approach	NN
10_1101-2020_09_09_289074	167	3	can	can	MD
10_1101-2020_09_09_289074	167	4	also	also	RB
10_1101-2020_09_09_289074	167	5	be	be	VB
10_1101-2020_09_09_289074	167	6	extended	extend	VBN
10_1101-2020_09_09_289074	167	7	to	to	IN
10_1101-2020_09_09_289074	167	8	other	other	JJ
10_1101-2020_09_09_289074	167	9	viruses	virus	NNS
10_1101-2020_09_09_289074	167	10	exploiting	exploit	VBG
10_1101-2020_09_09_289074	167	11	human	human	JJ
10_1101-2020_09_09_289074	167	12	receptors	receptor	NNS
10_1101-2020_09_09_289074	167	13	as	as	IN
10_1101-2020_09_09_289074	167	14	an	an	DT
10_1101-2020_09_09_289074	167	15	entry	entry	NN
10_1101-2020_09_09_289074	167	16	mechanism	mechanism	NN
10_1101-2020_09_09_289074	167	17	,	,	,
10_1101-2020_09_09_289074	167	18	such	such	JJ
10_1101-2020_09_09_289074	167	19	as	as	IN
10_1101-2020_09_09_289074	167	20	CD4	CD4	NNP
10_1101-2020_09_09_289074	167	21	for	for	IN
10_1101-2020_09_09_289074	167	22	the	the	DT
10_1101-2020_09_09_289074	167	23	Human	Human	NNP
10_1101-2020_09_09_289074	167	24	Immunodeficiency	Immunodeficiency	NNP
10_1101-2020_09_09_289074	167	25	Virus	Virus	NNP
10_1101-2020_09_09_289074	167	26	(	(	-LRB-
10_1101-2020_09_09_289074	167	27	HIV	HIV	NNP
10_1101-2020_09_09_289074	167	28	)	)	-RRB-
10_1101-2020_09_09_289074	167	29	or	or	CC
10_1101-2020_09_09_289074	167	30	TIM-1	TIM-1	NNP
10_1101-2020_09_09_289074	167	31	for	for	IN
10_1101-2020_09_09_289074	167	32	the	the	DT
10_1101-2020_09_09_289074	167	33	Ebola	Ebola	NNP
10_1101-2020_09_09_289074	167	34	virus	virus	NN
10_1101-2020_09_09_289074	167	35	(	(	-LRB-
10_1101-2020_09_09_289074	167	36	45	45	CD
10_1101-2020_09_09_289074	167	37	)	)	-RRB-
10_1101-2020_09_09_289074	167	38	.	.	.
10_1101-2020_09_09_289074	168	1	Materials	material	NNS
10_1101-2020_09_09_289074	168	2	and	and	CC
10_1101-2020_09_09_289074	168	3	Methods	Methods	NNP
10_1101-2020_09_09_289074	168	4	Structural	Structural	NNP
10_1101-2020_09_09_289074	168	5	analysis	analysis	NN
10_1101-2020_09_09_289074	168	6	The	the	DT
10_1101-2020_09_09_289074	168	7	PDB	PDB	NNP
10_1101-2020_09_09_289074	168	8	(	(	-LRB-
10_1101-2020_09_09_289074	168	9	46	46	CD
10_1101-2020_09_09_289074	168	10	)	)	-RRB-
10_1101-2020_09_09_289074	168	11	was	be	VBD
10_1101-2020_09_09_289074	168	12	searched	search	VBN
10_1101-2020_09_09_289074	168	13	for	for	IN
10_1101-2020_09_09_289074	168	14	high	high	JJ
10_1101-2020_09_09_289074	168	15	resolution	resolution	NN
10_1101-2020_09_09_289074	168	16	Spike	Spike	NNP
10_1101-2020_09_09_289074	168	17	/	/	SYM
10_1101-2020_09_09_289074	168	18	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	168	19	complexes	complex	NNS
10_1101-2020_09_09_289074	168	20	.	.	.
10_1101-2020_09_09_289074	169	1	PDB	PDB	NNP
10_1101-2020_09_09_289074	169	2	entries	entry	NNS
10_1101-2020_09_09_289074	169	3	6LZG	6LZG	NNP
10_1101-2020_09_09_289074	169	4	(	(	-LRB-
10_1101-2020_09_09_289074	169	5	10	10	CD
10_1101-2020_09_09_289074	169	6	)	)	-RRB-
10_1101-2020_09_09_289074	169	7	,	,	,
10_1101-2020_09_09_289074	169	8	6M0J	6m0j	CD
10_1101-2020_09_09_289074	169	9	(	(	-LRB-
10_1101-2020_09_09_289074	169	10	11	11	CD
10_1101-2020_09_09_289074	169	11	)	)	-RRB-
10_1101-2020_09_09_289074	169	12	and	and	CC
10_1101-2020_09_09_289074	169	13	6VW1	6VW1	NFP
10_1101-2020_09_09_289074	169	14	(	(	-LRB-
10_1101-2020_09_09_289074	169	15	12	12	CD
10_1101-2020_09_09_289074	169	16	)	)	-RRB-
10_1101-2020_09_09_289074	169	17	,	,	,
10_1101-2020_09_09_289074	169	18	reporting	report	VBG
10_1101-2020_09_09_289074	169	19	the	the	DT
10_1101-2020_09_09_289074	169	20	Spike	Spike	NNP
10_1101-2020_09_09_289074	169	21	RBD	RBD	NNP
10_1101-2020_09_09_289074	169	22	interacting	interact	VBG
10_1101-2020_09_09_289074	169	23	to	to	IN
10_1101-2020_09_09_289074	169	24	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	169	25	,	,	,
10_1101-2020_09_09_289074	169	26	have	have	VBP
10_1101-2020_09_09_289074	169	27	been	be	VBN
10_1101-2020_09_09_289074	169	28	retrieved	retrieve	VBN
10_1101-2020_09_09_289074	169	29	and	and	CC
10_1101-2020_09_09_289074	169	30	taken	take	VBN
10_1101-2020_09_09_289074	169	31	into	into	IN
10_1101-2020_09_09_289074	169	32	account	account	NN
10_1101-2020_09_09_289074	169	33	for	for	IN
10_1101-2020_09_09_289074	169	34	our	-PRON-	PRP$
10_1101-2020_09_09_289074	169	35	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	169	36	analysis	analysis	NN
10_1101-2020_09_09_289074	169	37	(	(	-LRB-
10_1101-2020_09_09_289074	169	38	28	28	CD
10_1101-2020_09_09_289074	169	39	)	)	-RRB-
10_1101-2020_09_09_289074	169	40	.	.	.
10_1101-2020_09_09_289074	170	1	Such	such	PDT
10_1101-2020_09_09_289074	170	2	a	a	DT
10_1101-2020_09_09_289074	170	3	computational	computational	JJ
10_1101-2020_09_09_289074	170	4	approach	approach	NN
10_1101-2020_09_09_289074	170	5	compares	compare	VBZ
10_1101-2020_09_09_289074	170	6	GRID	GRID	NNP
10_1101-2020_09_09_289074	170	7	(	(	-LRB-
10_1101-2020_09_09_289074	170	8	47	47	CD
10_1101-2020_09_09_289074	170	9	)	)	-RRB-
10_1101-2020_09_09_289074	170	10	molecular	molecular	JJ
10_1101-2020_09_09_289074	170	11	interaction	interaction	NN
10_1101-2020_09_09_289074	170	12	fields	field	NNS
10_1101-2020_09_09_289074	170	13	(	(	-LRB-
10_1101-2020_09_09_289074	170	14	MIFs	mif	NNS
10_1101-2020_09_09_289074	170	15	)	)	-RRB-
10_1101-2020_09_09_289074	170	16	computed	compute	VBD
10_1101-2020_09_09_289074	170	17	on	on	IN
10_1101-2020_09_09_289074	170	18	a	a	DT
10_1101-2020_09_09_289074	170	19	generic	generic	JJ
10_1101-2020_09_09_289074	170	20	complex	complex	NN
10_1101-2020_09_09_289074	170	21	(	(	-LRB-
10_1101-2020_09_09_289074	170	22	A	a	NN
10_1101-2020_09_09_289074	170	23	)	)	-RRB-
10_1101-2020_09_09_289074	170	24	and	and	CC
10_1101-2020_09_09_289074	170	25	on	on	IN
10_1101-2020_09_09_289074	170	26	its	-PRON-	PRP$
10_1101-2020_09_09_289074	170	27	host	host	NN
10_1101-2020_09_09_289074	170	28	(	(	-LRB-
10_1101-2020_09_09_289074	170	29	B	b	NN
10_1101-2020_09_09_289074	170	30	)	)	-RRB-
10_1101-2020_09_09_289074	170	31	and	and	CC
10_1101-2020_09_09_289074	170	32	guest	guest	NNP
10_1101-2020_09_09_289074	170	33	(	(	-LRB-
10_1101-2020_09_09_289074	170	34	C	c	NN
10_1101-2020_09_09_289074	170	35	)	)	-RRB-
10_1101-2020_09_09_289074	170	36	components	component	NNS
10_1101-2020_09_09_289074	170	37	,	,	,
10_1101-2020_09_09_289074	170	38	separately	separately	RB
10_1101-2020_09_09_289074	170	39	.	.	.
10_1101-2020_09_09_289074	171	1	Actually	actually	RB
10_1101-2020_09_09_289074	171	2	,	,	,
10_1101-2020_09_09_289074	171	3	MIFs	mif	NNS
10_1101-2020_09_09_289074	171	4	describe	describe	VBP
10_1101-2020_09_09_289074	171	5	the	the	DT
10_1101-2020_09_09_289074	171	6	interaction	interaction	NN
10_1101-2020_09_09_289074	171	7	between	between	IN
10_1101-2020_09_09_289074	171	8	a	a	DT
10_1101-2020_09_09_289074	171	9	certain	certain	JJ
10_1101-2020_09_09_289074	171	10	probe	probe	NN
10_1101-2020_09_09_289074	171	11	and	and	CC
10_1101-2020_09_09_289074	171	12	a	a	DT
10_1101-2020_09_09_289074	171	13	certain	certain	JJ
10_1101-2020_09_09_289074	171	14	target	target	NN
10_1101-2020_09_09_289074	171	15	.	.	.
10_1101-2020_09_09_289074	172	1	If	if	IN
10_1101-2020_09_09_289074	172	2	the	the	DT
10_1101-2020_09_09_289074	172	3	target	target	NN
10_1101-2020_09_09_289074	172	4	is	be	VBZ
10_1101-2020_09_09_289074	172	5	represented	represent	VBN
10_1101-2020_09_09_289074	172	6	by	by	IN
10_1101-2020_09_09_289074	172	7	a	a	DT
10_1101-2020_09_09_289074	172	8	complex	complex	NN
10_1101-2020_09_09_289074	172	9	,	,	,
10_1101-2020_09_09_289074	172	10	depending	depend	VBG
10_1101-2020_09_09_289074	172	11	on	on	IN
10_1101-2020_09_09_289074	172	12	the	the	DT
10_1101-2020_09_09_289074	172	13	selected	select	VBN
10_1101-2020_09_09_289074	172	14	area	area	NN
10_1101-2020_09_09_289074	172	15	,	,	,
10_1101-2020_09_09_289074	172	16	the	the	DT
10_1101-2020_09_09_289074	172	17	MIF	MIF	NNP
10_1101-2020_09_09_289074	172	18	energies	energy	NNS
10_1101-2020_09_09_289074	172	19	can	can	MD
10_1101-2020_09_09_289074	172	20	be	be	VB
10_1101-2020_09_09_289074	172	21	referred	refer	VBN
10_1101-2020_09_09_289074	172	22	to	to	IN
10_1101-2020_09_09_289074	172	23	the	the	DT
10_1101-2020_09_09_289074	172	24	interaction	interaction	NN
10_1101-2020_09_09_289074	172	25	between	between	IN
10_1101-2020_09_09_289074	172	26	the	the	DT
10_1101-2020_09_09_289074	172	27	probe	probe	NN
10_1101-2020_09_09_289074	172	28	and	and	CC
10_1101-2020_09_09_289074	172	29	one	one	CD
10_1101-2020_09_09_289074	172	30	of	of	IN
10_1101-2020_09_09_289074	172	31	the	the	DT
10_1101-2020_09_09_289074	172	32	complex	complex	JJ
10_1101-2020_09_09_289074	172	33	subunits	subunit	NNS
10_1101-2020_09_09_289074	172	34	or	or	CC
10_1101-2020_09_09_289074	172	35	,	,	,
10_1101-2020_09_09_289074	172	36	at	at	IN
10_1101-2020_09_09_289074	172	37	the	the	DT
10_1101-2020_09_09_289074	172	38	host	host	NN
10_1101-2020_09_09_289074	172	39	/	/	SYM
10_1101-2020_09_09_289074	172	40	guest	guest	NN
10_1101-2020_09_09_289074	172	41	interface	interface	NN
10_1101-2020_09_09_289074	172	42	,	,	,
10_1101-2020_09_09_289074	172	43	with	with	IN
10_1101-2020_09_09_289074	172	44	both	both	DT
10_1101-2020_09_09_289074	172	45	of	of	IN
10_1101-2020_09_09_289074	172	46	them	-PRON-	PRP
10_1101-2020_09_09_289074	172	47	.	.	.
10_1101-2020_09_09_289074	173	1	The	the	DT
10_1101-2020_09_09_289074	173	2	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	173	3	analysis	analysis	NN
10_1101-2020_09_09_289074	173	4	,	,	,
10_1101-2020_09_09_289074	173	5	objectively	objectively	RB
10_1101-2020_09_09_289074	173	6	,	,	,
10_1101-2020_09_09_289074	173	7	highlights	highlight	VBZ
10_1101-2020_09_09_289074	173	8	these	these	DT
10_1101-2020_09_09_289074	173	9	last	last	JJ
10_1101-2020_09_09_289074	173	10	.	.	.
10_1101-2020_09_09_289074	174	1	Five	five	CD
10_1101-2020_09_09_289074	174	2	steps	step	NNS
10_1101-2020_09_09_289074	174	3	are	be	VBP
10_1101-2020_09_09_289074	174	4	required	require	VBN
10_1101-2020_09_09_289074	174	5	:	:	:
10_1101-2020_09_09_289074	174	6	(	(	-LRB-
10_1101-2020_09_09_289074	174	7	1	1	LS
10_1101-2020_09_09_289074	174	8	)	)	-RRB-
10_1101-2020_09_09_289074	174	9	the	the	DT
10_1101-2020_09_09_289074	174	10	complex	complex	JJ
10_1101-2020_09_09_289074	174	11	A	A	NNP
10_1101-2020_09_09_289074	174	12	is	be	VBZ
10_1101-2020_09_09_289074	174	13	disassembled	disassemble	VBN
10_1101-2020_09_09_289074	174	14	in	in	IN
10_1101-2020_09_09_289074	174	15	its	-PRON-	PRP$
10_1101-2020_09_09_289074	174	16	subunits	subunit	NNS
10_1101-2020_09_09_289074	174	17	B	B	NNP
10_1101-2020_09_09_289074	174	18	and	and	CC
10_1101-2020_09_09_289074	174	19	C	C	NNP
10_1101-2020_09_09_289074	174	20	;	;	:
10_1101-2020_09_09_289074	174	21	(	(	-LRB-
10_1101-2020_09_09_289074	174	22	2	2	LS
10_1101-2020_09_09_289074	174	23	)	)	-RRB-
10_1101-2020_09_09_289074	174	24	MIFs	mif	NNS
10_1101-2020_09_09_289074	174	25	are	be	VBP
10_1101-2020_09_09_289074	174	26	computed	compute	VBN
10_1101-2020_09_09_289074	174	27	on	on	IN
10_1101-2020_09_09_289074	174	28	A	a	NN
10_1101-2020_09_09_289074	174	29	,	,	,
10_1101-2020_09_09_289074	174	30	B	b	NN
10_1101-2020_09_09_289074	174	31	and	and	CC
10_1101-2020_09_09_289074	174	32	C	C	NNP
10_1101-2020_09_09_289074	174	33	by	by	IN
10_1101-2020_09_09_289074	174	34	using	use	VBG
10_1101-2020_09_09_289074	174	35	the	the	DT
10_1101-2020_09_09_289074	174	36	most	most	RBS
10_1101-2020_09_09_289074	174	37	appropriate	appropriate	JJ
10_1101-2020_09_09_289074	174	38	GRID	GRID	NNP
10_1101-2020_09_09_289074	174	39	probes	probe	NNS
10_1101-2020_09_09_289074	174	40	.	.	.
10_1101-2020_09_09_289074	175	1	A	a	DT
10_1101-2020_09_09_289074	175	2	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	175	3	bond	bond	NN
10_1101-2020_09_09_289074	175	4	acceptor	acceptor	NN
10_1101-2020_09_09_289074	175	5	/	/	SYM
10_1101-2020_09_09_289074	175	6	donor	donor	NN
10_1101-2020_09_09_289074	175	7	and	and	CC
10_1101-2020_09_09_289074	175	8	a	a	DT
10_1101-2020_09_09_289074	175	9	generic	generic	JJ
10_1101-2020_09_09_289074	175	10	hydrophobic	hydrophobic	NN
10_1101-2020_09_09_289074	175	11	probe	probe	NN
10_1101-2020_09_09_289074	175	12	can	can	MD
10_1101-2020_09_09_289074	175	13	describe	describe	VB
10_1101-2020_09_09_289074	175	14	the	the	DT
10_1101-2020_09_09_289074	175	15	basic	basic	JJ
10_1101-2020_09_09_289074	175	16	interaction	interaction	NN
10_1101-2020_09_09_289074	175	17	.	.	.
10_1101-2020_09_09_289074	176	1	Because	because	IN
10_1101-2020_09_09_289074	176	2	GRID	GRID	NNP
10_1101-2020_09_09_289074	176	3	MIFs	mif	NNS
10_1101-2020_09_09_289074	176	4	are	be	VBP
10_1101-2020_09_09_289074	176	5	stored	store	VBN
10_1101-2020_09_09_289074	176	6	as	as	IN
10_1101-2020_09_09_289074	176	7	a	a	DT
10_1101-2020_09_09_289074	176	8	3D	3d	JJ
10_1101-2020_09_09_289074	176	9	matrix	matrix	NN
10_1101-2020_09_09_289074	176	10	of	of	IN
10_1101-2020_09_09_289074	176	11	interaction	interaction	NN
10_1101-2020_09_09_289074	176	12	energy	energy	NN
10_1101-2020_09_09_289074	176	13	points	point	NNS
10_1101-2020_09_09_289074	176	14	(	(	-LRB-
10_1101-2020_09_09_289074	176	15	IEP	IEP	NNP
10_1101-2020_09_09_289074	176	16	)	)	-RRB-
10_1101-2020_09_09_289074	176	17	,	,	,
10_1101-2020_09_09_289074	176	18	the	the	DT
10_1101-2020_09_09_289074	176	19	same	same	JJ
10_1101-2020_09_09_289074	176	20	box	box	NN
10_1101-2020_09_09_289074	176	21	dimensions	dimension	NNS
10_1101-2020_09_09_289074	176	22	are	be	VBP
10_1101-2020_09_09_289074	176	23	adopted	adopt	VBN
10_1101-2020_09_09_289074	176	24	in	in	IN
10_1101-2020_09_09_289074	176	25	all	all	DT
10_1101-2020_09_09_289074	176	26	calculations	calculation	NNS
10_1101-2020_09_09_289074	176	27	;	;	,
10_1101-2020_09_09_289074	176	28	(	(	-LRB-
10_1101-2020_09_09_289074	176	29	3	3	LS
10_1101-2020_09_09_289074	176	30	)	)	-RRB-
10_1101-2020_09_09_289074	176	31	each	each	DT
10_1101-2020_09_09_289074	176	32	IEP	iep	NN
10_1101-2020_09_09_289074	176	33	of	of	IN
10_1101-2020_09_09_289074	176	34	B	b	NN
10_1101-2020_09_09_289074	176	35	is	be	VBZ
10_1101-2020_09_09_289074	176	36	compared	compare	VBN
10_1101-2020_09_09_289074	176	37	with	with	IN
10_1101-2020_09_09_289074	176	38	respect	respect	NN
10_1101-2020_09_09_289074	176	39	to	to	IN
10_1101-2020_09_09_289074	176	40	the	the	DT
10_1101-2020_09_09_289074	176	41	equivalent	equivalent	JJ
10_1101-2020_09_09_289074	176	42	point	point	NN
10_1101-2020_09_09_289074	176	43	of	of	IN
10_1101-2020_09_09_289074	176	44	A	a	DT
10_1101-2020_09_09_289074	176	45	generating	generate	VBG
10_1101-2020_09_09_289074	176	46	a	a	DT
10_1101-2020_09_09_289074	176	47	new	new	JJ
10_1101-2020_09_09_289074	176	48	MIFs	mif	NNS
10_1101-2020_09_09_289074	176	49	named	name	VBN
10_1101-2020_09_09_289074	176	50	D.	D.	NNP
10_1101-2020_09_09_289074	176	51	The	the	DT
10_1101-2020_09_09_289074	176	52	following	follow	VBG
10_1101-2020_09_09_289074	176	53	algorithm	algorithm	NN
10_1101-2020_09_09_289074	176	54	,	,	,
10_1101-2020_09_09_289074	176	55	available	available	JJ
10_1101-2020_09_09_289074	176	56	into	into	IN
10_1101-2020_09_09_289074	176	57	the	the	DT
10_1101-2020_09_09_289074	176	58	GRAB	GRAB	NNP
10_1101-2020_09_09_289074	176	59	tool	tool	NN
10_1101-2020_09_09_289074	176	60	,	,	,
10_1101-2020_09_09_289074	176	61	is	be	VBZ
10_1101-2020_09_09_289074	176	62	applied	apply	VBN
10_1101-2020_09_09_289074	176	63	:	:	:
10_1101-2020_09_09_289074	176	64	if	if	IN
10_1101-2020_09_09_289074	176	65	IEP(A	IEP(A	NNP
10_1101-2020_09_09_289074	176	66	)	)	-RRB-
10_1101-2020_09_09_289074	176	67	>	>	XX
10_1101-2020_09_09_289074	176	68	0	0	NFP
10_1101-2020_09_09_289074	176	69	and	and	CC
10_1101-2020_09_09_289074	176	70	IEP(B	IEP(B	NNP
10_1101-2020_09_09_289074	176	71	)	)	-RRB-
10_1101-2020_09_09_289074	176	72	>	>	XX
10_1101-2020_09_09_289074	176	73	0	0	NFP
10_1101-2020_09_09_289074	176	74	then	then	RB
10_1101-2020_09_09_289074	176	75	IEP(D	IEP(D	NNP
10_1101-2020_09_09_289074	176	76	)	)	-RRB-
10_1101-2020_09_09_289074	176	77	=	=	SYM
10_1101-2020_09_09_289074	176	78	0	0	NFP
10_1101-2020_09_09_289074	176	79	;	;	:
10_1101-2020_09_09_289074	176	80	if	if	IN
10_1101-2020_09_09_289074	176	81	IEP(A	IEP(A	NNP
10_1101-2020_09_09_289074	176	82	)	)	-RRB-
10_1101-2020_09_09_289074	176	83	>	>	XX
10_1101-2020_09_09_289074	176	84	0	0	NFP
10_1101-2020_09_09_289074	176	85	and	and	CC
10_1101-2020_09_09_289074	176	86	IEP(B	IEP(B	NNP
10_1101-2020_09_09_289074	176	87	)	)	-RRB-
10_1101-2020_09_09_289074	176	88	<	<	XX
10_1101-2020_09_09_289074	176	89	0	0	NFP
10_1101-2020_09_09_289074	176	90	then	then	RB
10_1101-2020_09_09_289074	176	91	IEP(D	IEP(D	NNP
10_1101-2020_09_09_289074	176	92	)	)	-RRB-
10_1101-2020_09_09_289074	176	93	=	=	NFP
10_1101-2020_09_09_289074	176	94	IEP(B	IEP(B	NNP
10_1101-2020_09_09_289074	176	95	)	)	-RRB-
10_1101-2020_09_09_289074	176	96	;	;	:
10_1101-2020_09_09_289074	176	97	if	if	IN
10_1101-2020_09_09_289074	176	98	IEP(A	IEP(A	NNP
10_1101-2020_09_09_289074	176	99	)	)	-RRB-
10_1101-2020_09_09_289074	176	100	<	<	XX
10_1101-2020_09_09_289074	176	101	0	0	NFP
10_1101-2020_09_09_289074	176	102	and	and	CC
10_1101-2020_09_09_289074	176	103	IEP(B	IEP(B	NNP
10_1101-2020_09_09_289074	176	104	)	)	-RRB-
10_1101-2020_09_09_289074	176	105	>	>	XX
10_1101-2020_09_09_289074	176	106	0	0	NFP
10_1101-2020_09_09_289074	176	107	then	then	RB
10_1101-2020_09_09_289074	176	108	IEP(D	IEP(D	NNP
10_1101-2020_09_09_289074	176	109	)	)	-RRB-
10_1101-2020_09_09_289074	176	110	.CC	.CC	:
10_1101-2020_09_09_289074	176	111	-	-	:
10_1101-2020_09_09_289074	176	112	BY	by	IN
10_1101-2020_09_09_289074	176	113	-	-	HYPH
10_1101-2020_09_09_289074	176	114	NC	NC	NNP
10_1101-2020_09_09_289074	176	115	-	-	HYPH
10_1101-2020_09_09_289074	176	116	ND	ND	NNP
10_1101-2020_09_09_289074	176	117	4.0	4.0	CD
10_1101-2020_09_09_289074	176	118	International	International	NNP
10_1101-2020_09_09_289074	176	119	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	176	120	under	under	IN
10_1101-2020_09_09_289074	176	121	a	a	DT
10_1101-2020_09_09_289074	176	122	(	(	-LRB-
10_1101-2020_09_09_289074	176	123	which	which	WDT
10_1101-2020_09_09_289074	176	124	was	be	VBD
10_1101-2020_09_09_289074	176	125	not	not	RB
10_1101-2020_09_09_289074	176	126	certified	certify	VBN
10_1101-2020_09_09_289074	176	127	by	by	IN
10_1101-2020_09_09_289074	176	128	peer	peer	NN
10_1101-2020_09_09_289074	176	129	review	review	NN
10_1101-2020_09_09_289074	176	130	)	)	-RRB-
10_1101-2020_09_09_289074	176	131	is	be	VBZ
10_1101-2020_09_09_289074	176	132	the	the	DT
10_1101-2020_09_09_289074	176	133	author	author	NN
10_1101-2020_09_09_289074	176	134	/	/	SYM
10_1101-2020_09_09_289074	176	135	funder	funder	NN
10_1101-2020_09_09_289074	176	136	,	,	,
10_1101-2020_09_09_289074	176	137	who	who	WP
10_1101-2020_09_09_289074	176	138	has	have	VBZ
10_1101-2020_09_09_289074	176	139	granted	grant	VBN
10_1101-2020_09_09_289074	176	140	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	176	141	a	a	DT
10_1101-2020_09_09_289074	176	142	license	license	NN
10_1101-2020_09_09_289074	176	143	to	to	TO
10_1101-2020_09_09_289074	176	144	display	display	VB
10_1101-2020_09_09_289074	176	145	the	the	DT
10_1101-2020_09_09_289074	176	146	preprint	preprint	NN
10_1101-2020_09_09_289074	176	147	in	in	IN
10_1101-2020_09_09_289074	176	148	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	176	149	.	.	.
10_1101-2020_09_09_289074	177	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	177	2	is	be	VBZ
10_1101-2020_09_09_289074	177	3	made	make	VBN
10_1101-2020_09_09_289074	177	4	The	the	DT
10_1101-2020_09_09_289074	177	5	copyright	copyright	NN
10_1101-2020_09_09_289074	177	6	holder	holder	NN
10_1101-2020_09_09_289074	177	7	for	for	IN
10_1101-2020_09_09_289074	177	8	this	this	DT
10_1101-2020_09_09_289074	177	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	177	10	version	version	NN
10_1101-2020_09_09_289074	177	11	posted	post	VBD
10_1101-2020_09_09_289074	177	12	January	January	NNP
10_1101-2020_09_09_289074	177	13	5	5	CD
10_1101-2020_09_09_289074	177	14	,	,	,
10_1101-2020_09_09_289074	177	15	2021	2021	CD
10_1101-2020_09_09_289074	177	16	.	.	.
10_1101-2020_09_09_289074	177	17	;	;	:
10_1101-2020_09_09_289074	177	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	177	19	:	:	:
10_1101-2020_09_09_289074	177	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	177	21	preprint	preprint	NN
10_1101-2020_09_09_289074	177	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	177	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	177	24	10	10	CD
10_1101-2020_09_09_289074	177	25	=	=	SYM
10_1101-2020_09_09_289074	177	26	-IEP(A	-IEP(A	NNS
10_1101-2020_09_09_289074	177	27	)	)	-RRB-
10_1101-2020_09_09_289074	177	28	;	;	:
10_1101-2020_09_09_289074	177	29	if	if	IN
10_1101-2020_09_09_289074	177	30	IEP(A	IEP(A	NNP
10_1101-2020_09_09_289074	177	31	)	)	-RRB-
10_1101-2020_09_09_289074	177	32	<	<	XX
10_1101-2020_09_09_289074	177	33	0	0	NFP
10_1101-2020_09_09_289074	177	34	and	and	CC
10_1101-2020_09_09_289074	177	35	IEP(B	IEP(B	NNP
10_1101-2020_09_09_289074	177	36	)	)	-RRB-
10_1101-2020_09_09_289074	177	37	<	<	XX
10_1101-2020_09_09_289074	177	38	0	0	NFP
10_1101-2020_09_09_289074	177	39	then	then	RB
10_1101-2020_09_09_289074	177	40	IEP(D	IEP(D	NNP
10_1101-2020_09_09_289074	177	41	)	)	-RRB-
10_1101-2020_09_09_289074	177	42	=	=	NFP
10_1101-2020_09_09_289074	177	43	IEP(A)-IEP(B	IEP(A)-IEP(B	NNS
10_1101-2020_09_09_289074	177	44	)	)	-RRB-
10_1101-2020_09_09_289074	177	45	.	.	.
10_1101-2020_09_09_289074	178	1	The	the	DT
10_1101-2020_09_09_289074	178	2	resulting	result	VBG
10_1101-2020_09_09_289074	178	3	MIF	MIF	NNP
10_1101-2020_09_09_289074	178	4	D	D	NNP
10_1101-2020_09_09_289074	178	5	reports	report	NNS
10_1101-2020_09_09_289074	178	6	as	as	IN
10_1101-2020_09_09_289074	178	7	negative	negative	JJ
10_1101-2020_09_09_289074	178	8	energy	energy	NN
10_1101-2020_09_09_289074	178	9	values	value	NNS
10_1101-2020_09_09_289074	178	10	the	the	DT
10_1101-2020_09_09_289074	178	11	productive	productive	JJ
10_1101-2020_09_09_289074	178	12	interaction	interaction	NN
10_1101-2020_09_09_289074	178	13	between	between	IN
10_1101-2020_09_09_289074	178	14	the	the	DT
10_1101-2020_09_09_289074	178	15	GRID	GRID	NNP
10_1101-2020_09_09_289074	178	16	probe	probe	NN
10_1101-2020_09_09_289074	178	17	and	and	CC
10_1101-2020_09_09_289074	178	18	B	b	NN
10_1101-2020_09_09_289074	178	19	and	and	CC
10_1101-2020_09_09_289074	178	20	the	the	DT
10_1101-2020_09_09_289074	178	21	interface	interface	NN
10_1101-2020_09_09_289074	178	22	A	a	NN
10_1101-2020_09_09_289074	178	23	and	and	CC
10_1101-2020_09_09_289074	178	24	B	b	NN
10_1101-2020_09_09_289074	178	25	;	;	:
10_1101-2020_09_09_289074	178	26	(	(	-LRB-
10_1101-2020_09_09_289074	178	27	4	4	LS
10_1101-2020_09_09_289074	178	28	)	)	-RRB-
10_1101-2020_09_09_289074	178	29	in	in	IN
10_1101-2020_09_09_289074	178	30	order	order	NN
10_1101-2020_09_09_289074	178	31	to	to	TO
10_1101-2020_09_09_289074	178	32	obscure	obscure	VB
10_1101-2020_09_09_289074	178	33	the	the	DT
10_1101-2020_09_09_289074	178	34	interaction	interaction	NN
10_1101-2020_09_09_289074	178	35	between	between	IN
10_1101-2020_09_09_289074	178	36	the	the	DT
10_1101-2020_09_09_289074	178	37	probe	probe	NN
10_1101-2020_09_09_289074	178	38	and	and	CC
10_1101-2020_09_09_289074	178	39	B	b	NN
10_1101-2020_09_09_289074	178	40	,	,	,
10_1101-2020_09_09_289074	178	41	MIFs	mif	NNS
10_1101-2020_09_09_289074	178	42	D	d	NN
10_1101-2020_09_09_289074	178	43	and	and	CC
10_1101-2020_09_09_289074	178	44	C	C	NNP
10_1101-2020_09_09_289074	178	45	are	be	VBP
10_1101-2020_09_09_289074	178	46	compared	compare	VBN
10_1101-2020_09_09_289074	178	47	,	,	,
10_1101-2020_09_09_289074	178	48	by	by	IN
10_1101-2020_09_09_289074	178	49	using	use	VBG
10_1101-2020_09_09_289074	178	50	the	the	DT
10_1101-2020_09_09_289074	178	51	GRAB	GRAB	NNP
10_1101-2020_09_09_289074	178	52	approach	approach	NN
10_1101-2020_09_09_289074	178	53	,	,	,
10_1101-2020_09_09_289074	178	54	producing	produce	VBG
10_1101-2020_09_09_289074	178	55	to	to	IN
10_1101-2020_09_09_289074	178	56	a	a	DT
10_1101-2020_09_09_289074	178	57	new	new	JJ
10_1101-2020_09_09_289074	178	58	MIF	MIF	NNP
10_1101-2020_09_09_289074	178	59	E	e	NN
10_1101-2020_09_09_289074	178	60	;	;	,
10_1101-2020_09_09_289074	178	61	(	(	-LRB-
10_1101-2020_09_09_289074	178	62	5	5	LS
10_1101-2020_09_09_289074	178	63	)	)	-RRB-
10_1101-2020_09_09_289074	178	64	the	the	DT
10_1101-2020_09_09_289074	178	65	most	most	RBS
10_1101-2020_09_09_289074	178	66	relevant	relevant	JJ
10_1101-2020_09_09_289074	178	67	interaction	interaction	NN
10_1101-2020_09_09_289074	178	68	points	point	NNS
10_1101-2020_09_09_289074	178	69	(	(	-LRB-
10_1101-2020_09_09_289074	178	70	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	178	71	features	feature	NNS
10_1101-2020_09_09_289074	178	72	)	)	-RRB-
10_1101-2020_09_09_289074	178	73	of	of	IN
10_1101-2020_09_09_289074	178	74	the	the	DT
10_1101-2020_09_09_289074	178	75	MIF	MIF	NNP
10_1101-2020_09_09_289074	178	76	E	e	NN
10_1101-2020_09_09_289074	178	77	are	be	VBP
10_1101-2020_09_09_289074	178	78	,	,	,
10_1101-2020_09_09_289074	178	79	finally	finally	RB
10_1101-2020_09_09_289074	178	80	,	,	,
10_1101-2020_09_09_289074	178	81	selected	select	VBN
10_1101-2020_09_09_289074	178	82	taking	take	VBG
10_1101-2020_09_09_289074	178	83	into	into	IN
10_1101-2020_09_09_289074	178	84	account	account	NN
10_1101-2020_09_09_289074	178	85	an	an	DT
10_1101-2020_09_09_289074	178	86	energy	energy	NN
10_1101-2020_09_09_289074	178	87	cutoff	cutoff	NN
10_1101-2020_09_09_289074	178	88	15	15	CD
10_1101-2020_09_09_289074	178	89	%	%	NN
10_1101-2020_09_09_289074	178	90	above	above	IN
10_1101-2020_09_09_289074	178	91	the	the	DT
10_1101-2020_09_09_289074	178	92	global	global	JJ
10_1101-2020_09_09_289074	178	93	minimum	minimum	NN
10_1101-2020_09_09_289074	178	94	.	.	.
10_1101-2020_09_09_289074	179	1	Supplementary	supplementary	JJ
10_1101-2020_09_09_289074	179	2	figures	figure	NNS
10_1101-2020_09_09_289074	179	3	focusing	focus	VBG
10_1101-2020_09_09_289074	179	4	on	on	IN
10_1101-2020_09_09_289074	179	5	the	the	DT
10_1101-2020_09_09_289074	179	6	most	most	RBS
10_1101-2020_09_09_289074	179	7	relevant	relevant	JJ
10_1101-2020_09_09_289074	179	8	mutation	mutation	NN
10_1101-2020_09_09_289074	179	9	are	be	VBP
10_1101-2020_09_09_289074	179	10	available	available	JJ
10_1101-2020_09_09_289074	179	11	in	in	IN
10_1101-2020_09_09_289074	179	12	Supplementary	Supplementary	NNP
10_1101-2020_09_09_289074	179	13	File	File	NNP
10_1101-2020_09_09_289074	179	14	3	3	CD
10_1101-2020_09_09_289074	179	15	.	.	.
10_1101-2020_09_09_289074	180	1	Before	before	IN
10_1101-2020_09_09_289074	180	2	starting	start	VBG
10_1101-2020_09_09_289074	180	3	the	the	DT
10_1101-2020_09_09_289074	180	4	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	180	5	analysis	analysis	NN
10_1101-2020_09_09_289074	180	6	,	,	,
10_1101-2020_09_09_289074	180	7	co	co	JJ
10_1101-2020_09_09_289074	180	8	-	-	JJ
10_1101-2020_09_09_289074	180	9	crystalized	crystalized	JJ
10_1101-2020_09_09_289074	180	10	water	water	NN
10_1101-2020_09_09_289074	180	11	molecules	molecule	NNS
10_1101-2020_09_09_289074	180	12	were	be	VBD
10_1101-2020_09_09_289074	180	13	removed	remove	VBN
10_1101-2020_09_09_289074	180	14	from	from	IN
10_1101-2020_09_09_289074	180	15	PDB	PDB	NNP
10_1101-2020_09_09_289074	180	16	structures	structure	NNS
10_1101-2020_09_09_289074	180	17	.	.	.
10_1101-2020_09_09_289074	181	1	In	in	IN
10_1101-2020_09_09_289074	181	2	6VW1	6vw1	CD
10_1101-2020_09_09_289074	181	3	,	,	,
10_1101-2020_09_09_289074	181	4	showing	show	VBG
10_1101-2020_09_09_289074	181	5	two	two	CD
10_1101-2020_09_09_289074	181	6	Spike	Spike	NNP
10_1101-2020_09_09_289074	181	7	-	-	HYPH
10_1101-2020_09_09_289074	181	8	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	181	9	complexes	complex	NNS
10_1101-2020_09_09_289074	181	10	,	,	,
10_1101-2020_09_09_289074	181	11	namely	namely	RB
10_1101-2020_09_09_289074	181	12	chains	chain	VBZ
10_1101-2020_09_09_289074	181	13	A	a	NN
10_1101-2020_09_09_289074	181	14	-	-	HYPH
10_1101-2020_09_09_289074	181	15	E	e	NN
10_1101-2020_09_09_289074	181	16	and	and	CC
10_1101-2020_09_09_289074	181	17	B	B	NNP
10_1101-2020_09_09_289074	181	18	-	-	HYPH
10_1101-2020_09_09_289074	181	19	F	F	NNP
10_1101-2020_09_09_289074	181	20	,	,	,
10_1101-2020_09_09_289074	181	21	both	both	DT
10_1101-2020_09_09_289074	181	22	structures	structure	NNS
10_1101-2020_09_09_289074	181	23	have	have	VBP
10_1101-2020_09_09_289074	181	24	been	be	VBN
10_1101-2020_09_09_289074	181	25	investigated	investigate	VBN
10_1101-2020_09_09_289074	181	26	and	and	CC
10_1101-2020_09_09_289074	181	27	further	further	RB
10_1101-2020_09_09_289074	181	28	reported	report	VBN
10_1101-2020_09_09_289074	181	29	as	as	IN
10_1101-2020_09_09_289074	181	30	model	model	NN
10_1101-2020_09_09_289074	181	31	A	a	NN
10_1101-2020_09_09_289074	181	32	and	and	CC
10_1101-2020_09_09_289074	181	33	B	b	NN
10_1101-2020_09_09_289074	181	34	,	,	,
10_1101-2020_09_09_289074	181	35	respectively	respectively	RB
10_1101-2020_09_09_289074	181	36	.	.	.
10_1101-2020_09_09_289074	182	1	All	all	DT
10_1101-2020_09_09_289074	182	2	selected	select	VBN
10_1101-2020_09_09_289074	182	3	complexes	complex	NNS
10_1101-2020_09_09_289074	182	4	have	have	VBP
10_1101-2020_09_09_289074	182	5	been	be	VBN
10_1101-2020_09_09_289074	182	6	conformationally	conformationally	RB
10_1101-2020_09_09_289074	182	7	compared	compare	VBN
10_1101-2020_09_09_289074	182	8	one	one	CD
10_1101-2020_09_09_289074	182	9	each	each	DT
10_1101-2020_09_09_289074	182	10	other	other	JJ
10_1101-2020_09_09_289074	182	11	by	by	IN
10_1101-2020_09_09_289074	182	12	alignment	alignment	NN
10_1101-2020_09_09_289074	182	13	and	and	CC
10_1101-2020_09_09_289074	182	14	computing	compute	VBG
10_1101-2020_09_09_289074	182	15	the	the	DT
10_1101-2020_09_09_289074	182	16	RMSd	RMSd	NNS
10_1101-2020_09_09_289074	182	17	on	on	IN
10_1101-2020_09_09_289074	182	18	the	the	DT
10_1101-2020_09_09_289074	182	19	cartesian	cartesian	JJ
10_1101-2020_09_09_289074	182	20	coordinates	coordinate	NNS
10_1101-2020_09_09_289074	182	21	of	of	IN
10_1101-2020_09_09_289074	182	22	equivalent	equivalent	JJ
10_1101-2020_09_09_289074	182	23	not	not	RB
10_1101-2020_09_09_289074	182	24	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	182	25	atoms	atom	NNS
10_1101-2020_09_09_289074	182	26	.	.	.
10_1101-2020_09_09_289074	183	1	DRY	DRY	NNP
10_1101-2020_09_09_289074	183	2	,	,	,
10_1101-2020_09_09_289074	183	3	N1	n1	NN
10_1101-2020_09_09_289074	183	4	and	and	CC
10_1101-2020_09_09_289074	183	5	O	o	UH
10_1101-2020_09_09_289074	183	6	original	original	JJ
10_1101-2020_09_09_289074	183	7	GRID	GRID	NNP
10_1101-2020_09_09_289074	183	8	probes	probe	NNS
10_1101-2020_09_09_289074	183	9	have	have	VBP
10_1101-2020_09_09_289074	183	10	been	be	VBN
10_1101-2020_09_09_289074	183	11	used	use	VBN
10_1101-2020_09_09_289074	183	12	to	to	TO
10_1101-2020_09_09_289074	183	13	highlight	highlight	VB
10_1101-2020_09_09_289074	183	14	hydrophobic	hydrophobic	NN
10_1101-2020_09_09_289074	183	15	,	,	,
10_1101-2020_09_09_289074	183	16	hydrogen	hydrogen	NNP
10_1101-2020_09_09_289074	183	17	bond	bond	NN
10_1101-2020_09_09_289074	183	18	donors	donor	NNS
10_1101-2020_09_09_289074	183	19	and	and	CC
10_1101-2020_09_09_289074	183	20	acceptors	acceptor	NNS
10_1101-2020_09_09_289074	183	21	areas	area	NNS
10_1101-2020_09_09_289074	183	22	.	.	.
10_1101-2020_09_09_289074	184	1	In	in	IN
10_1101-2020_09_09_289074	184	2	order	order	NN
10_1101-2020_09_09_289074	184	3	to	to	TO
10_1101-2020_09_09_289074	184	4	identify	identify	VB
10_1101-2020_09_09_289074	184	5	the	the	DT
10_1101-2020_09_09_289074	184	6	most	most	RBS
10_1101-2020_09_09_289074	184	7	relevant	relevant	JJ
10_1101-2020_09_09_289074	184	8	residues	residue	NNS
10_1101-2020_09_09_289074	184	9	of	of	IN
10_1101-2020_09_09_289074	184	10	both	both	CC
10_1101-2020_09_09_289074	184	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	184	12	and	and	CC
10_1101-2020_09_09_289074	184	13	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	184	14	,	,	,
10_1101-2020_09_09_289074	184	15	we	-PRON-	PRP
10_1101-2020_09_09_289074	184	16	conceptually	conceptually	RB
10_1101-2020_09_09_289074	184	17	and	and	CC
10_1101-2020_09_09_289074	184	18	technically	technically	RB
10_1101-2020_09_09_289074	184	19	extended	extend	VBD
10_1101-2020_09_09_289074	184	20	the	the	DT
10_1101-2020_09_09_289074	184	21	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	184	22	algorithm	algorithm	NN
10_1101-2020_09_09_289074	184	23	,	,	,
10_1101-2020_09_09_289074	184	24	originally	originally	RB
10_1101-2020_09_09_289074	184	25	designed	design	VBN
10_1101-2020_09_09_289074	184	26	for	for	IN
10_1101-2020_09_09_289074	184	27	drug	drug	NN
10_1101-2020_09_09_289074	184	28	/	/	SYM
10_1101-2020_09_09_289074	184	29	target	target	NN
10_1101-2020_09_09_289074	184	30	interactions	interaction	NNS
10_1101-2020_09_09_289074	184	31	(	(	-LRB-
10_1101-2020_09_09_289074	184	32	28	28	CD
10_1101-2020_09_09_289074	184	33	)	)	-RRB-
10_1101-2020_09_09_289074	184	34	.	.	.
10_1101-2020_09_09_289074	185	1	In	in	IN
10_1101-2020_09_09_289074	185	2	the	the	DT
10_1101-2020_09_09_289074	185	3	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	185	4	analysis	analysis	NN
10_1101-2020_09_09_289074	185	5	presented	present	VBN
10_1101-2020_09_09_289074	185	6	here	here	RB
10_1101-2020_09_09_289074	185	7	,	,	,
10_1101-2020_09_09_289074	185	8	the	the	DT
10_1101-2020_09_09_289074	185	9	two	two	CD
10_1101-2020_09_09_289074	185	10	interacting	interact	VBG
10_1101-2020_09_09_289074	185	11	proteins	protein	NNS
10_1101-2020_09_09_289074	185	12	have	have	VBP
10_1101-2020_09_09_289074	185	13	been	be	VBN
10_1101-2020_09_09_289074	185	14	considered	consider	VBN
10_1101-2020_09_09_289074	185	15	either	either	CC
10_1101-2020_09_09_289074	185	16	as	as	IN
10_1101-2020_09_09_289074	185	17	host	host	NN
10_1101-2020_09_09_289074	185	18	and	and	CC
10_1101-2020_09_09_289074	185	19	guest	guest	NN
10_1101-2020_09_09_289074	185	20	units	unit	NNS
10_1101-2020_09_09_289074	185	21	,	,	,
10_1101-2020_09_09_289074	185	22	and	and	CC
10_1101-2020_09_09_289074	185	23	relevant	relevant	JJ
10_1101-2020_09_09_289074	185	24	AAs	aa	NNS
10_1101-2020_09_09_289074	185	25	were	be	VBD
10_1101-2020_09_09_289074	185	26	selected	select	VBN
10_1101-2020_09_09_289074	185	27	if	if	IN
10_1101-2020_09_09_289074	185	28	their	-PRON-	PRP$
10_1101-2020_09_09_289074	185	29	distance	distance	NN
10_1101-2020_09_09_289074	185	30	from	from	IN
10_1101-2020_09_09_289074	185	31	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	185	32	features	feature	NNS
10_1101-2020_09_09_289074	185	33	was	be	VBD
10_1101-2020_09_09_289074	185	34	lower	low	JJR
10_1101-2020_09_09_289074	185	35	or	or	CC
10_1101-2020_09_09_289074	185	36	equal	equal	JJ
10_1101-2020_09_09_289074	185	37	to	to	IN
10_1101-2020_09_09_289074	185	38	3	3	CD
10_1101-2020_09_09_289074	185	39	Å.	å.	NN
10_1101-2020_09_09_289074	186	1	For	for	IN
10_1101-2020_09_09_289074	186	2	each	each	DT
10_1101-2020_09_09_289074	186	3	PDB	PDB	NNP
10_1101-2020_09_09_289074	186	4	model	model	NN
10_1101-2020_09_09_289074	186	5	,	,	,
10_1101-2020_09_09_289074	186	6	the	the	DT
10_1101-2020_09_09_289074	186	7	selected	select	VBN
10_1101-2020_09_09_289074	186	8	residues	residue	NNS
10_1101-2020_09_09_289074	186	9	were	be	VBD
10_1101-2020_09_09_289074	186	10	scored	score	VBN
10_1101-2020_09_09_289074	186	11	as	as	IN
10_1101-2020_09_09_289074	186	12	summa	summa	JJR
10_1101-2020_09_09_289074	186	13	of	of	IN
10_1101-2020_09_09_289074	186	14	the	the	DT
10_1101-2020_09_09_289074	186	15	corresponding	correspond	VBG
10_1101-2020_09_09_289074	186	16	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	186	17	features	feature	VBZ
10_1101-2020_09_09_289074	186	18	interaction	interaction	NN
10_1101-2020_09_09_289074	186	19	energy	energy	NN
10_1101-2020_09_09_289074	186	20	.	.	.
10_1101-2020_09_09_289074	187	1	In	in	IN
10_1101-2020_09_09_289074	187	2	order	order	NN
10_1101-2020_09_09_289074	187	3	to	to	TO
10_1101-2020_09_09_289074	187	4	prevent	prevent	VB
10_1101-2020_09_09_289074	187	5	unrealistic	unrealistic	JJ
10_1101-2020_09_09_289074	187	6	distortion	distortion	NN
10_1101-2020_09_09_289074	187	7	of	of	IN
10_1101-2020_09_09_289074	187	8	the	the	DT
10_1101-2020_09_09_289074	187	9	Spike	Spike	NNP
10_1101-2020_09_09_289074	187	10	-	-	HYPH
10_1101-2020_09_09_289074	187	11	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	187	12	complex	complex	NN
10_1101-2020_09_09_289074	187	13	,	,	,
10_1101-2020_09_09_289074	187	14	due	due	JJ
10_1101-2020_09_09_289074	187	15	the	the	DT
10_1101-2020_09_09_289074	187	16	usage	usage	NN
10_1101-2020_09_09_289074	187	17	of	of	IN
10_1101-2020_09_09_289074	187	18	structures	structure	NNS
10_1101-2020_09_09_289074	187	19	not	not	RB
10_1101-2020_09_09_289074	187	20	covering	cover	VBG
10_1101-2020_09_09_289074	187	21	the	the	DT
10_1101-2020_09_09_289074	187	22	full	full	JJ
10_1101-2020_09_09_289074	187	23	length	length	NN
10_1101-2020_09_09_289074	187	24	of	of	IN
10_1101-2020_09_09_289074	187	25	the	the	DT
10_1101-2020_09_09_289074	187	26	interacting	interact	VBG
10_1101-2020_09_09_289074	187	27	proteins	protein	NNS
10_1101-2020_09_09_289074	187	28	,	,	,
10_1101-2020_09_09_289074	187	29	the	the	DT
10_1101-2020_09_09_289074	187	30	mutations	mutation	NNS
10_1101-2020_09_09_289074	187	31	effect	effect	NN
10_1101-2020_09_09_289074	187	32	has	have	VBZ
10_1101-2020_09_09_289074	187	33	been	be	VBN
10_1101-2020_09_09_289074	187	34	qualitatively	qualitatively	RB
10_1101-2020_09_09_289074	187	35	estimated	estimate	VBN
10_1101-2020_09_09_289074	187	36	by	by	IN
10_1101-2020_09_09_289074	187	37	means	mean	NNS
10_1101-2020_09_09_289074	187	38	of	of	IN
10_1101-2020_09_09_289074	187	39	the	the	DT
10_1101-2020_09_09_289074	187	40	mutagenesis	mutagenesis	NN
10_1101-2020_09_09_289074	187	41	tool	tool	NN
10_1101-2020_09_09_289074	187	42	implemented	implement	VBN
10_1101-2020_09_09_289074	187	43	in	in	IN
10_1101-2020_09_09_289074	187	44	PyMol	PyMol	NNP
10_1101-2020_09_09_289074	187	45	software	software	NN
10_1101-2020_09_09_289074	187	46	(	(	-LRB-
10_1101-2020_09_09_289074	187	47	48	48	CD
10_1101-2020_09_09_289074	187	48	)	)	-RRB-
10_1101-2020_09_09_289074	187	49	.	.	.
10_1101-2020_09_09_289074	188	1	Wild	wild	JJ
10_1101-2020_09_09_289074	188	2	type	type	NN
10_1101-2020_09_09_289074	188	3	residues	residue	NNS
10_1101-2020_09_09_289074	188	4	have	have	VBP
10_1101-2020_09_09_289074	188	5	been	be	VBN
10_1101-2020_09_09_289074	188	6	replaced	replace	VBN
10_1101-2020_09_09_289074	188	7	by	by	IN
10_1101-2020_09_09_289074	188	8	the	the	DT
10_1101-2020_09_09_289074	188	9	mutation	mutation	NN
10_1101-2020_09_09_289074	188	10	and	and	CC
10_1101-2020_09_09_289074	188	11	the	the	DT
10_1101-2020_09_09_289074	188	12	new	new	JJ
10_1101-2020_09_09_289074	188	13	sidechain	sidechain	JJ
10_1101-2020_09_09_289074	188	14	conformations	conformation	NNS
10_1101-2020_09_09_289074	188	15	have	have	VBP
10_1101-2020_09_09_289074	188	16	been	be	VBN
10_1101-2020_09_09_289074	188	17	optimized	optimize	VBN
10_1101-2020_09_09_289074	188	18	taking	take	VBG
10_1101-2020_09_09_289074	188	19	into	into	IN
10_1101-2020_09_09_289074	188	20	account	account	NN
10_1101-2020_09_09_289074	188	21	the	the	DT
10_1101-2020_09_09_289074	188	22	neighboring	neighbor	VBG
10_1101-2020_09_09_289074	188	23	AAs	aa	NNS
10_1101-2020_09_09_289074	188	24	.	.	.
10_1101-2020_09_09_289074	189	1	The	the	DT
10_1101-2020_09_09_289074	189	2	graphical	graphical	JJ
10_1101-2020_09_09_289074	189	3	analysis	analysis	NN
10_1101-2020_09_09_289074	189	4	was	be	VBD
10_1101-2020_09_09_289074	189	5	carried	carry	VBN
10_1101-2020_09_09_289074	189	6	out	out	RP
10_1101-2020_09_09_289074	189	7	onto	onto	IN
10_1101-2020_09_09_289074	189	8	the	the	DT
10_1101-2020_09_09_289074	189	9	predicted	predict	VBN
10_1101-2020_09_09_289074	189	10	most	most	RBS
10_1101-2020_09_09_289074	189	11	populated	populated	JJ
10_1101-2020_09_09_289074	189	12	rotamers	rotamer	NNS
10_1101-2020_09_09_289074	189	13	.	.	.
10_1101-2020_09_09_289074	190	1	On	on	IN
10_1101-2020_09_09_289074	190	2	the	the	DT
10_1101-2020_09_09_289074	190	3	basis	basis	NN
10_1101-2020_09_09_289074	190	4	of	of	IN
10_1101-2020_09_09_289074	190	5	its	-PRON-	PRP$
10_1101-2020_09_09_289074	190	6	better	well	JJR
10_1101-2020_09_09_289074	190	7	X	x	NN
10_1101-2020_09_09_289074	190	8	-	-	NN
10_1101-2020_09_09_289074	190	9	ray	ray	NN
10_1101-2020_09_09_289074	190	10	resolution	resolution	NN
10_1101-2020_09_09_289074	190	11	,	,	,
10_1101-2020_09_09_289074	190	12	the	the	DT
10_1101-2020_09_09_289074	190	13	6M0J	6m0j	CD
10_1101-2020_09_09_289074	190	14	PDB	PDB	NNP
10_1101-2020_09_09_289074	190	15	structure	structure	NN
10_1101-2020_09_09_289074	190	16	has	have	VBZ
10_1101-2020_09_09_289074	190	17	been	be	VBN
10_1101-2020_09_09_289074	190	18	selected	select	VBN
10_1101-2020_09_09_289074	190	19	for	for	IN
10_1101-2020_09_09_289074	190	20	the	the	DT
10_1101-2020_09_09_289074	190	21	above	above	RB
10_1101-2020_09_09_289074	190	22	reported	report	VBN
10_1101-2020_09_09_289074	190	23	investigation	investigation	NN
10_1101-2020_09_09_289074	190	24	.	.	.
10_1101-2020_09_09_289074	191	1	Genetical	genetical	JJ
10_1101-2020_09_09_289074	191	2	analysis	analysis	NN
10_1101-2020_09_09_289074	191	3	SARS	SARS	NNP
10_1101-2020_09_09_289074	191	4	-	-	HYPH
10_1101-2020_09_09_289074	191	5	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	191	6	genome	genome	JJ
10_1101-2020_09_09_289074	191	7	sequences	sequence	NNS
10_1101-2020_09_09_289074	191	8	from	from	IN
10_1101-2020_09_09_289074	191	9	human	human	JJ
10_1101-2020_09_09_289074	191	10	hosts	host	NNS
10_1101-2020_09_09_289074	191	11	and	and	CC
10_1101-2020_09_09_289074	191	12	accounting	account	VBG
10_1101-2020_09_09_289074	191	13	for	for	IN
10_1101-2020_09_09_289074	191	14	a	a	DT
10_1101-2020_09_09_289074	191	15	total	total	NN
10_1101-2020_09_09_289074	191	16	of	of	IN
10_1101-2020_09_09_289074	191	17	145,201	145,201	CD
10_1101-2020_09_09_289074	191	18	submissions	submission	NNS
10_1101-2020_09_09_289074	191	19	were	be	VBD
10_1101-2020_09_09_289074	191	20	obtained	obtain	VBN
10_1101-2020_09_09_289074	191	21	from	from	IN
10_1101-2020_09_09_289074	191	22	the	the	DT
10_1101-2020_09_09_289074	191	23	GISAID	GISAID	NNP
10_1101-2020_09_09_289074	191	24	database	database	NN
10_1101-2020_09_09_289074	191	25	on	on	IN
10_1101-2020_09_09_289074	191	26	15	15	CD
10_1101-2020_09_09_289074	191	27	October	October	NNP
10_1101-2020_09_09_289074	191	28	2020	2020	CD
10_1101-2020_09_09_289074	191	29	(	(	-LRB-
10_1101-2020_09_09_289074	191	30	29	29	CD
10_1101-2020_09_09_289074	191	31	)	)	-RRB-
10_1101-2020_09_09_289074	191	32	.	.	.
10_1101-2020_09_09_289074	192	1	Low	low	JJ
10_1101-2020_09_09_289074	192	2	quality	quality	NN
10_1101-2020_09_09_289074	192	3	(	(	-LRB-
10_1101-2020_09_09_289074	192	4	with	with	IN
10_1101-2020_09_09_289074	192	5	more	more	JJR
10_1101-2020_09_09_289074	192	6	than	than	IN
10_1101-2020_09_09_289074	192	7	5	5	CD
10_1101-2020_09_09_289074	192	8	%	%	NN
10_1101-2020_09_09_289074	192	9	uncharacterized	uncharacterized	JJ
10_1101-2020_09_09_289074	192	10	nucleotides	nucleotide	NNS
10_1101-2020_09_09_289074	192	11	)	)	-RRB-
10_1101-2020_09_09_289074	192	12	and	and	CC
10_1101-2020_09_09_289074	192	13	incomplete	incomplete	JJ
10_1101-2020_09_09_289074	192	14	(	(	-LRB-
10_1101-2020_09_09_289074	192	15	<	<	XX
10_1101-2020_09_09_289074	192	16	29,000	29,000	CD
10_1101-2020_09_09_289074	192	17	nucleotides	nucleotide	NNS
10_1101-2020_09_09_289074	192	18	,	,	,
10_1101-2020_09_09_289074	192	19	based	base	VBN
10_1101-2020_09_09_289074	192	20	on	on	IN
10_1101-2020_09_09_289074	192	21	a	a	DT
10_1101-2020_09_09_289074	192	22	total	total	JJ
10_1101-2020_09_09_289074	192	23	reference	reference	NN
10_1101-2020_09_09_289074	192	24	length	length	NN
10_1101-2020_09_09_289074	192	25	of	of	IN
10_1101-2020_09_09_289074	192	26	29,903	29,903	CD
10_1101-2020_09_09_289074	192	27	)	)	-RRB-
10_1101-2020_09_09_289074	192	28	sequences	sequence	NNS
10_1101-2020_09_09_289074	192	29	were	be	VBD
10_1101-2020_09_09_289074	192	30	removed	remove	VBN
10_1101-2020_09_09_289074	192	31	.	.	.
10_1101-2020_09_09_289074	193	1	The	the	DT
10_1101-2020_09_09_289074	193	2	resulting	result	VBG
10_1101-2020_09_09_289074	193	3	135,591	135,591	CD
10_1101-2020_09_09_289074	193	4	genome	genome	NN
10_1101-2020_09_09_289074	193	5	sequences	sequence	NNS
10_1101-2020_09_09_289074	193	6	were	be	VBD
10_1101-2020_09_09_289074	193	7	aligned	align	VBN
10_1101-2020_09_09_289074	193	8	on	on	IN
10_1101-2020_09_09_289074	193	9	the	the	DT
10_1101-2020_09_09_289074	193	10	reference	reference	NN
10_1101-2020_09_09_289074	193	11	SARS	SARS	NNP
10_1101-2020_09_09_289074	193	12	-	-	HYPH
10_1101-2020_09_09_289074	193	13	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	193	14	Wuhan	Wuhan	NNP
10_1101-2020_09_09_289074	193	15	genome	genome	NNP
10_1101-2020_09_09_289074	193	16	(	(	-LRB-
10_1101-2020_09_09_289074	193	17	NCBI	NCBI	NNP
10_1101-2020_09_09_289074	193	18	entry	entry	NN
10_1101-2020_09_09_289074	193	19	NC_045512.2	NC_045512.2	NNP
10_1101-2020_09_09_289074	193	20	)	)	-RRB-
10_1101-2020_09_09_289074	193	21	using	use	VBG
10_1101-2020_09_09_289074	193	22	the	the	DT
10_1101-2020_09_09_289074	193	23	NUCMER	NUCMER	NNP
10_1101-2020_09_09_289074	193	24	algorithm	algorithm	NN
10_1101-2020_09_09_289074	193	25	(	(	-LRB-
10_1101-2020_09_09_289074	193	26	49	49	CD
10_1101-2020_09_09_289074	193	27	)	)	-RRB-
10_1101-2020_09_09_289074	193	28	.	.	.
10_1101-2020_09_09_289074	194	1	Position	position	NN
10_1101-2020_09_09_289074	194	2	-	-	HYPH
10_1101-2020_09_09_289074	194	3	specific	specific	JJ
10_1101-2020_09_09_289074	194	4	nucleotide	nucleotide	JJ
10_1101-2020_09_09_289074	194	5	differences	difference	NNS
10_1101-2020_09_09_289074	194	6	were	be	VBD
10_1101-2020_09_09_289074	194	7	merged	merge	VBN
10_1101-2020_09_09_289074	194	8	for	for	IN
10_1101-2020_09_09_289074	194	9	neighboring	neighbor	VBG
10_1101-2020_09_09_289074	194	10	events	event	NNS
10_1101-2020_09_09_289074	194	11	and	and	CC
10_1101-2020_09_09_289074	194	12	converted	convert	VBN
10_1101-2020_09_09_289074	194	13	into	into	IN
10_1101-2020_09_09_289074	194	14	protein	protein	NN
10_1101-2020_09_09_289074	194	15	mutations	mutation	NNS
10_1101-2020_09_09_289074	194	16	using	use	VBG
10_1101-2020_09_09_289074	194	17	the	the	DT
10_1101-2020_09_09_289074	194	18	coronapp	coronapp	NNP
10_1101-2020_09_09_289074	194	19	annotator	annotator	NN
10_1101-2020_09_09_289074	194	20	(	(	-LRB-
10_1101-2020_09_09_289074	194	21	17	17	CD
10_1101-2020_09_09_289074	194	22	)	)	-RRB-
10_1101-2020_09_09_289074	194	23	.	.	.
10_1101-2020_09_09_289074	195	1	The	the	DT
10_1101-2020_09_09_289074	195	2	results	result	NNS
10_1101-2020_09_09_289074	195	3	were	be	VBD
10_1101-2020_09_09_289074	195	4	further	further	RB
10_1101-2020_09_09_289074	195	5	filtered	filter	VBN
10_1101-2020_09_09_289074	195	6	for	for	IN
10_1101-2020_09_09_289074	195	7	AA-	aa-	NN
10_1101-2020_09_09_289074	195	8	changing	change	VBG
10_1101-2020_09_09_289074	195	9	mutations	mutation	NNS
10_1101-2020_09_09_289074	195	10	targeting	target	VBG
10_1101-2020_09_09_289074	195	11	the	the	DT
10_1101-2020_09_09_289074	195	12	Spike	Spike	NNP
10_1101-2020_09_09_289074	195	13	protein	protein	NN
10_1101-2020_09_09_289074	195	14	.	.	.
10_1101-2020_09_09_289074	196	1	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	196	2	variants	variant	NNS
10_1101-2020_09_09_289074	196	3	in	in	IN
10_1101-2020_09_09_289074	196	4	the	the	DT
10_1101-2020_09_09_289074	196	5	human	human	JJ
10_1101-2020_09_09_289074	196	6	population	population	NN
10_1101-2020_09_09_289074	196	7	were	be	VBD
10_1101-2020_09_09_289074	196	8	extracted	extract	VBN
10_1101-2020_09_09_289074	196	9	from	from	IN
10_1101-2020_09_09_289074	196	10	the	the	DT
10_1101-2020_09_09_289074	196	11	gnomAD	gnomAD	NNP
10_1101-2020_09_09_289074	196	12	database	database	NN
10_1101-2020_09_09_289074	196	13	,	,	,
10_1101-2020_09_09_289074	196	14	v3	v3	NN
10_1101-2020_09_09_289074	196	15	,	,	,
10_1101-2020_09_09_289074	196	16	18	18	CD
10_1101-2020_09_09_289074	196	17	July	July	NNP
10_1101-2020_09_09_289074	196	18	2020	2020	CD
10_1101-2020_09_09_289074	196	19	(	(	-LRB-
10_1101-2020_09_09_289074	196	20	50	50	CD
10_1101-2020_09_09_289074	196	21	)	)	-RRB-
10_1101-2020_09_09_289074	196	22	.	.	.
10_1101-2020_09_09_289074	197	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	197	2	considered	consider	VBD
10_1101-2020_09_09_289074	197	3	only	only	RB
10_1101-2020_09_09_289074	197	4	missense	missense	NN
10_1101-2020_09_09_289074	197	5	variants	variant	NNS
10_1101-2020_09_09_289074	197	6	affecting	affect	VBG
10_1101-2020_09_09_289074	197	7	specific	specific	JJ
10_1101-2020_09_09_289074	197	8	AAs	aa	NNS
10_1101-2020_09_09_289074	197	9	in	in	IN
10_1101-2020_09_09_289074	197	10	the	the	DT
10_1101-2020_09_09_289074	197	11	protein	protein	NN
10_1101-2020_09_09_289074	197	12	sequence	sequence	NN
10_1101-2020_09_09_289074	197	13	,	,	,
10_1101-2020_09_09_289074	197	14	for	for	IN
10_1101-2020_09_09_289074	197	15	a	a	DT
10_1101-2020_09_09_289074	197	16	total	total	NN
10_1101-2020_09_09_289074	197	17	of	of	IN
10_1101-2020_09_09_289074	197	18	155	155	CD
10_1101-2020_09_09_289074	197	19	entries	entry	NNS
10_1101-2020_09_09_289074	197	20	(	(	-LRB-
10_1101-2020_09_09_289074	197	21	Supplementary	Supplementary	NNP
10_1101-2020_09_09_289074	197	22	File	File	NNP
10_1101-2020_09_09_289074	197	23	2	2	CD
10_1101-2020_09_09_289074	197	24	)	)	-RRB-
10_1101-2020_09_09_289074	197	25	.	.	.
10_1101-2020_09_09_289074	198	1	Graph	graph	NN
10_1101-2020_09_09_289074	198	2	generation	generation	NN
10_1101-2020_09_09_289074	198	3	was	be	VBD
10_1101-2020_09_09_289074	198	4	performed	perform	VBN
10_1101-2020_09_09_289074	198	5	with	with	IN
10_1101-2020_09_09_289074	198	6	the	the	DT
10_1101-2020_09_09_289074	198	7	R	r	JJ
10_1101-2020_09_09_289074	198	8	statistical	statistical	JJ
10_1101-2020_09_09_289074	198	9	software	software	NN
10_1101-2020_09_09_289074	198	10	and	and	CC
10_1101-2020_09_09_289074	198	11	the	the	DT
10_1101-2020_09_09_289074	198	12	corto	corto	NN
10_1101-2020_09_09_289074	198	13	package	package	NN
10_1101-2020_09_09_289074	198	14	v1.1.2	v1.1.2	NNP
10_1101-2020_09_09_289074	198	15	(	(	-LRB-
10_1101-2020_09_09_289074	198	16	51	51	CD
10_1101-2020_09_09_289074	198	17	)	)	-RRB-
10_1101-2020_09_09_289074	198	18	.	.	.
10_1101-2020_09_09_289074	199	1	.CC	.CC	NFP
10_1101-2020_09_09_289074	199	2	-	-	:
10_1101-2020_09_09_289074	199	3	BY	by	IN
10_1101-2020_09_09_289074	199	4	-	-	HYPH
10_1101-2020_09_09_289074	199	5	NC	NC	NNP
10_1101-2020_09_09_289074	199	6	-	-	HYPH
10_1101-2020_09_09_289074	199	7	ND	ND	NNP
10_1101-2020_09_09_289074	199	8	4.0	4.0	CD
10_1101-2020_09_09_289074	199	9	International	International	NNP
10_1101-2020_09_09_289074	199	10	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	199	11	under	under	IN
10_1101-2020_09_09_289074	199	12	a	a	DT
10_1101-2020_09_09_289074	199	13	(	(	-LRB-
10_1101-2020_09_09_289074	199	14	which	which	WDT
10_1101-2020_09_09_289074	199	15	was	be	VBD
10_1101-2020_09_09_289074	199	16	not	not	RB
10_1101-2020_09_09_289074	199	17	certified	certify	VBN
10_1101-2020_09_09_289074	199	18	by	by	IN
10_1101-2020_09_09_289074	199	19	peer	peer	NN
10_1101-2020_09_09_289074	199	20	review	review	NN
10_1101-2020_09_09_289074	199	21	)	)	-RRB-
10_1101-2020_09_09_289074	199	22	is	be	VBZ
10_1101-2020_09_09_289074	199	23	the	the	DT
10_1101-2020_09_09_289074	199	24	author	author	NN
10_1101-2020_09_09_289074	199	25	/	/	SYM
10_1101-2020_09_09_289074	199	26	funder	funder	NN
10_1101-2020_09_09_289074	199	27	,	,	,
10_1101-2020_09_09_289074	199	28	who	who	WP
10_1101-2020_09_09_289074	199	29	has	have	VBZ
10_1101-2020_09_09_289074	199	30	granted	grant	VBN
10_1101-2020_09_09_289074	199	31	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	199	32	a	a	DT
10_1101-2020_09_09_289074	199	33	license	license	NN
10_1101-2020_09_09_289074	199	34	to	to	TO
10_1101-2020_09_09_289074	199	35	display	display	VB
10_1101-2020_09_09_289074	199	36	the	the	DT
10_1101-2020_09_09_289074	199	37	preprint	preprint	NN
10_1101-2020_09_09_289074	199	38	in	in	IN
10_1101-2020_09_09_289074	199	39	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	199	40	.	.	.
10_1101-2020_09_09_289074	200	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	200	2	is	be	VBZ
10_1101-2020_09_09_289074	200	3	made	make	VBN
10_1101-2020_09_09_289074	200	4	The	the	DT
10_1101-2020_09_09_289074	200	5	copyright	copyright	NN
10_1101-2020_09_09_289074	200	6	holder	holder	NN
10_1101-2020_09_09_289074	200	7	for	for	IN
10_1101-2020_09_09_289074	200	8	this	this	DT
10_1101-2020_09_09_289074	200	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	200	10	version	version	NN
10_1101-2020_09_09_289074	200	11	posted	post	VBD
10_1101-2020_09_09_289074	200	12	January	January	NNP
10_1101-2020_09_09_289074	200	13	5	5	CD
10_1101-2020_09_09_289074	200	14	,	,	,
10_1101-2020_09_09_289074	200	15	2021	2021	CD
10_1101-2020_09_09_289074	200	16	.	.	.
10_1101-2020_09_09_289074	200	17	;	;	:
10_1101-2020_09_09_289074	200	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	200	19	:	:	:
10_1101-2020_09_09_289074	200	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	200	21	preprint	preprint	NN
10_1101-2020_09_09_289074	200	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	200	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	200	24	11	11	CD
10_1101-2020_09_09_289074	200	25	Acknowledgments	acknowledgment	NNS
10_1101-2020_09_09_289074	200	26	We	-PRON-	PRP
10_1101-2020_09_09_289074	200	27	thank	thank	VBP
10_1101-2020_09_09_289074	200	28	the	the	DT
10_1101-2020_09_09_289074	200	29	Italian	Italian	NNP
10_1101-2020_09_09_289074	200	30	Ministry	Ministry	NNP
10_1101-2020_09_09_289074	200	31	of	of	IN
10_1101-2020_09_09_289074	200	32	Education	Education	NNP
10_1101-2020_09_09_289074	200	33	and	and	CC
10_1101-2020_09_09_289074	200	34	Research	Research	NNP
10_1101-2020_09_09_289074	200	35	for	for	IN
10_1101-2020_09_09_289074	200	36	their	-PRON-	PRP$
10_1101-2020_09_09_289074	200	37	financial	financial	JJ
10_1101-2020_09_09_289074	200	38	support	support	NN
10_1101-2020_09_09_289074	200	39	under	under	IN
10_1101-2020_09_09_289074	200	40	the	the	DT
10_1101-2020_09_09_289074	200	41	Montalcini	Montalcini	NNP
10_1101-2020_09_09_289074	200	42	initiative	initiative	NN
10_1101-2020_09_09_289074	200	43	.	.	.
10_1101-2020_09_09_289074	201	1	We	-PRON-	PRP
10_1101-2020_09_09_289074	201	2	thank	thank	VBP
10_1101-2020_09_09_289074	201	3	Prof.	Prof.	NNP
10_1101-2020_09_09_289074	201	4	Giovanni	Giovanni	NNP
10_1101-2020_09_09_289074	201	5	Perini	Perini	NNP
10_1101-2020_09_09_289074	201	6	for	for	IN
10_1101-2020_09_09_289074	201	7	his	-PRON-	PRP$
10_1101-2020_09_09_289074	201	8	continued	continued	JJ
10_1101-2020_09_09_289074	201	9	support	support	NN
10_1101-2020_09_09_289074	201	10	and	and	CC
10_1101-2020_09_09_289074	201	11	scientific	scientific	JJ
10_1101-2020_09_09_289074	201	12	enthusiasm	enthusiasm	NN
10_1101-2020_09_09_289074	201	13	,	,	,
10_1101-2020_09_09_289074	201	14	Prof.	Prof.	NNP
10_1101-2020_09_09_289074	201	15	Massimo	Massimo	NNP
10_1101-2020_09_09_289074	201	16	Battistini	Battistini	NNP
10_1101-2020_09_09_289074	201	17	for	for	IN
10_1101-2020_09_09_289074	201	18	his	-PRON-	PRP$
10_1101-2020_09_09_289074	201	19	lessons	lesson	NNS
10_1101-2020_09_09_289074	201	20	on	on	IN
10_1101-2020_09_09_289074	201	21	logic	logic	NN
10_1101-2020_09_09_289074	201	22	and	and	CC
10_1101-2020_09_09_289074	201	23	writing	writing	NN
10_1101-2020_09_09_289074	201	24	,	,	,
10_1101-2020_09_09_289074	201	25	Prof.	Prof.	NNP
10_1101-2020_09_09_289074	201	26	Elena	Elena	NNP
10_1101-2020_09_09_289074	201	27	Bacchelli	Bacchelli	NNP
10_1101-2020_09_09_289074	201	28	for	for	IN
10_1101-2020_09_09_289074	201	29	her	-PRON-	PRP$
10_1101-2020_09_09_289074	201	30	suggestions	suggestion	NNS
10_1101-2020_09_09_289074	201	31	on	on	IN
10_1101-2020_09_09_289074	201	32	the	the	DT
10_1101-2020_09_09_289074	201	33	use	use	NN
10_1101-2020_09_09_289074	201	34	of	of	IN
10_1101-2020_09_09_289074	201	35	gnomAD	gnomAD	NNP
10_1101-2020_09_09_289074	201	36	,	,	,
10_1101-2020_09_09_289074	201	37	and	and	CC
10_1101-2020_09_09_289074	201	38	Prof.	Prof.	NNP
10_1101-2020_09_09_289074	201	39	Stefano	Stefano	NNP
10_1101-2020_09_09_289074	201	40	Alcaro	Alcaro	NNP
10_1101-2020_09_09_289074	201	41	who	who	WP
10_1101-2020_09_09_289074	201	42	provided	provide	VBD
10_1101-2020_09_09_289074	201	43	the	the	DT
10_1101-2020_09_09_289074	201	44	computational	computational	JJ
10_1101-2020_09_09_289074	201	45	resources	resource	NNS
10_1101-2020_09_09_289074	201	46	required	require	VBN
10_1101-2020_09_09_289074	201	47	by	by	IN
10_1101-2020_09_09_289074	201	48	the	the	DT
10_1101-2020_09_09_289074	201	49	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	201	50	analysis	analysis	NN
10_1101-2020_09_09_289074	201	51	.	.	.
10_1101-2020_09_09_289074	202	1	Finally	finally	RB
10_1101-2020_09_09_289074	202	2	,	,	,
10_1101-2020_09_09_289074	202	3	we	-PRON-	PRP
10_1101-2020_09_09_289074	202	4	thank	thank	VBP
10_1101-2020_09_09_289074	202	5	Mr.	Mr.	NNP
10_1101-2020_09_09_289074	202	6	George	George	NNP
10_1101-2020_09_09_289074	202	7	Wolf	Wolf	NNP
10_1101-2020_09_09_289074	202	8	for	for	IN
10_1101-2020_09_09_289074	202	9	the	the	DT
10_1101-2020_09_09_289074	202	10	final	final	JJ
10_1101-2020_09_09_289074	202	11	proofreading	proofreading	NN
10_1101-2020_09_09_289074	202	12	the	the	DT
10_1101-2020_09_09_289074	202	13	manuscript	manuscript	NN
10_1101-2020_09_09_289074	202	14	.	.	.
10_1101-2020_09_09_289074	203	1	References	reference	NNS
10_1101-2020_09_09_289074	203	2	.CC	.CC	NFP
10_1101-2020_09_09_289074	203	3	-	-	HYPH
10_1101-2020_09_09_289074	203	4	BY	by	IN
10_1101-2020_09_09_289074	203	5	-	-	HYPH
10_1101-2020_09_09_289074	203	6	NC	NC	NNP
10_1101-2020_09_09_289074	203	7	-	-	HYPH
10_1101-2020_09_09_289074	203	8	ND	ND	NNP
10_1101-2020_09_09_289074	203	9	4.0	4.0	CD
10_1101-2020_09_09_289074	203	10	International	International	NNP
10_1101-2020_09_09_289074	203	11	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	203	12	under	under	IN
10_1101-2020_09_09_289074	203	13	a	a	DT
10_1101-2020_09_09_289074	203	14	(	(	-LRB-
10_1101-2020_09_09_289074	203	15	which	which	WDT
10_1101-2020_09_09_289074	203	16	was	be	VBD
10_1101-2020_09_09_289074	203	17	not	not	RB
10_1101-2020_09_09_289074	203	18	certified	certify	VBN
10_1101-2020_09_09_289074	203	19	by	by	IN
10_1101-2020_09_09_289074	203	20	peer	peer	NN
10_1101-2020_09_09_289074	203	21	review	review	NN
10_1101-2020_09_09_289074	203	22	)	)	-RRB-
10_1101-2020_09_09_289074	203	23	is	be	VBZ
10_1101-2020_09_09_289074	203	24	the	the	DT
10_1101-2020_09_09_289074	203	25	author	author	NN
10_1101-2020_09_09_289074	203	26	/	/	SYM
10_1101-2020_09_09_289074	203	27	funder	funder	NN
10_1101-2020_09_09_289074	203	28	,	,	,
10_1101-2020_09_09_289074	203	29	who	who	WP
10_1101-2020_09_09_289074	203	30	has	have	VBZ
10_1101-2020_09_09_289074	203	31	granted	grant	VBN
10_1101-2020_09_09_289074	203	32	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	203	33	a	a	DT
10_1101-2020_09_09_289074	203	34	license	license	NN
10_1101-2020_09_09_289074	203	35	to	to	TO
10_1101-2020_09_09_289074	203	36	display	display	VB
10_1101-2020_09_09_289074	203	37	the	the	DT
10_1101-2020_09_09_289074	203	38	preprint	preprint	NN
10_1101-2020_09_09_289074	203	39	in	in	IN
10_1101-2020_09_09_289074	203	40	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	203	41	.	.	.
10_1101-2020_09_09_289074	204	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	204	2	is	be	VBZ
10_1101-2020_09_09_289074	204	3	made	make	VBN
10_1101-2020_09_09_289074	204	4	The	the	DT
10_1101-2020_09_09_289074	204	5	copyright	copyright	NN
10_1101-2020_09_09_289074	204	6	holder	holder	NN
10_1101-2020_09_09_289074	204	7	for	for	IN
10_1101-2020_09_09_289074	204	8	this	this	DT
10_1101-2020_09_09_289074	204	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	204	10	version	version	NN
10_1101-2020_09_09_289074	204	11	posted	post	VBD
10_1101-2020_09_09_289074	204	12	January	January	NNP
10_1101-2020_09_09_289074	204	13	5	5	CD
10_1101-2020_09_09_289074	204	14	,	,	,
10_1101-2020_09_09_289074	204	15	2021	2021	CD
10_1101-2020_09_09_289074	204	16	.	.	.
10_1101-2020_09_09_289074	204	17	;	;	:
10_1101-2020_09_09_289074	204	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	204	19	:	:	:
10_1101-2020_09_09_289074	204	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	204	21	preprint	preprint	NN
10_1101-2020_09_09_289074	204	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	204	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	204	24	12	12	CD
10_1101-2020_09_09_289074	204	25	Figures	figure	NNS
10_1101-2020_09_09_289074	204	26	and	and	CC
10_1101-2020_09_09_289074	204	27	Tables	Tables	NNPS
10_1101-2020_09_09_289074	204	28	.CC	.CC	:
10_1101-2020_09_09_289074	204	29	-	-	HYPH
10_1101-2020_09_09_289074	204	30	BY	by	IN
10_1101-2020_09_09_289074	204	31	-	-	HYPH
10_1101-2020_09_09_289074	204	32	NC	NC	NNP
10_1101-2020_09_09_289074	204	33	-	-	HYPH
10_1101-2020_09_09_289074	204	34	ND	ND	NNP
10_1101-2020_09_09_289074	204	35	4.0	4.0	CD
10_1101-2020_09_09_289074	204	36	International	International	NNP
10_1101-2020_09_09_289074	204	37	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	204	38	under	under	IN
10_1101-2020_09_09_289074	204	39	a	a	DT
10_1101-2020_09_09_289074	204	40	(	(	-LRB-
10_1101-2020_09_09_289074	204	41	which	which	WDT
10_1101-2020_09_09_289074	204	42	was	be	VBD
10_1101-2020_09_09_289074	204	43	not	not	RB
10_1101-2020_09_09_289074	204	44	certified	certify	VBN
10_1101-2020_09_09_289074	204	45	by	by	IN
10_1101-2020_09_09_289074	204	46	peer	peer	NN
10_1101-2020_09_09_289074	204	47	review	review	NN
10_1101-2020_09_09_289074	204	48	)	)	-RRB-
10_1101-2020_09_09_289074	204	49	is	be	VBZ
10_1101-2020_09_09_289074	204	50	the	the	DT
10_1101-2020_09_09_289074	204	51	author	author	NN
10_1101-2020_09_09_289074	204	52	/	/	SYM
10_1101-2020_09_09_289074	204	53	funder	funder	NN
10_1101-2020_09_09_289074	204	54	,	,	,
10_1101-2020_09_09_289074	204	55	who	who	WP
10_1101-2020_09_09_289074	204	56	has	have	VBZ
10_1101-2020_09_09_289074	204	57	granted	grant	VBN
10_1101-2020_09_09_289074	204	58	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	204	59	a	a	DT
10_1101-2020_09_09_289074	204	60	license	license	NN
10_1101-2020_09_09_289074	204	61	to	to	TO
10_1101-2020_09_09_289074	204	62	display	display	VB
10_1101-2020_09_09_289074	204	63	the	the	DT
10_1101-2020_09_09_289074	204	64	preprint	preprint	NN
10_1101-2020_09_09_289074	204	65	in	in	IN
10_1101-2020_09_09_289074	204	66	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	204	67	.	.	.
10_1101-2020_09_09_289074	205	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	205	2	is	be	VBZ
10_1101-2020_09_09_289074	205	3	made	make	VBN
10_1101-2020_09_09_289074	205	4	The	the	DT
10_1101-2020_09_09_289074	205	5	copyright	copyright	NN
10_1101-2020_09_09_289074	205	6	holder	holder	NN
10_1101-2020_09_09_289074	205	7	for	for	IN
10_1101-2020_09_09_289074	205	8	this	this	DT
10_1101-2020_09_09_289074	205	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	205	10	version	version	NN
10_1101-2020_09_09_289074	205	11	posted	post	VBD
10_1101-2020_09_09_289074	205	12	January	January	NNP
10_1101-2020_09_09_289074	205	13	5	5	CD
10_1101-2020_09_09_289074	205	14	,	,	,
10_1101-2020_09_09_289074	205	15	2021	2021	CD
10_1101-2020_09_09_289074	205	16	.	.	.
10_1101-2020_09_09_289074	205	17	;	;	:
10_1101-2020_09_09_289074	205	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	205	19	:	:	:
10_1101-2020_09_09_289074	205	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	205	21	preprint	preprint	NN
10_1101-2020_09_09_289074	205	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	205	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	205	24	13	13	CD
10_1101-2020_09_09_289074	205	25	Figure	figure	NN
10_1101-2020_09_09_289074	205	26	1	1	CD
10_1101-2020_09_09_289074	205	27	.	.	.
10_1101-2020_09_09_289074	206	1	Conformational	conformational	JJ
10_1101-2020_09_09_289074	206	2	comparison	comparison	NN
10_1101-2020_09_09_289074	206	3	of	of	IN
10_1101-2020_09_09_289074	206	4	Spike	Spike	NNP
10_1101-2020_09_09_289074	206	5	-	-	HYPH
10_1101-2020_09_09_289074	206	6	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	206	7	PDB	PDB	NNP
10_1101-2020_09_09_289074	206	8	complexes	complex	NNS
10_1101-2020_09_09_289074	206	9	:	:	:
10_1101-2020_09_09_289074	206	10	(	(	-LRB-
10_1101-2020_09_09_289074	206	11	A	a	NN
10_1101-2020_09_09_289074	206	12	)	)	-RRB-
10_1101-2020_09_09_289074	206	13	alignment	alignment	NN
10_1101-2020_09_09_289074	206	14	of	of	IN
10_1101-2020_09_09_289074	206	15	PDB	PDB	NNP
10_1101-2020_09_09_289074	206	16	entries	entry	NNS
10_1101-2020_09_09_289074	206	17	,	,	,
10_1101-2020_09_09_289074	206	18	Spike	Spike	NNP
10_1101-2020_09_09_289074	206	19	and	and	CC
10_1101-2020_09_09_289074	206	20	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	206	21	are	be	VBP
10_1101-2020_09_09_289074	206	22	respectively	respectively	RB
10_1101-2020_09_09_289074	206	23	surrounded	surround	VBN
10_1101-2020_09_09_289074	206	24	by	by	IN
10_1101-2020_09_09_289074	206	25	cyan	cyan	NNP
10_1101-2020_09_09_289074	206	26	and	and	CC
10_1101-2020_09_09_289074	206	27	orange	orange	NNP
10_1101-2020_09_09_289074	206	28	fog	fog	NNP
10_1101-2020_09_09_289074	206	29	,	,	,
10_1101-2020_09_09_289074	206	30	and	and	CC
10_1101-2020_09_09_289074	206	31	(	(	-LRB-
10_1101-2020_09_09_289074	206	32	B	b	NN
10_1101-2020_09_09_289074	206	33	)	)	-RRB-
10_1101-2020_09_09_289074	206	34	bar	bar	NN
10_1101-2020_09_09_289074	206	35	graph	graph	NN
10_1101-2020_09_09_289074	206	36	showing	show	VBG
10_1101-2020_09_09_289074	206	37	RMSd	RMSd	NNS
10_1101-2020_09_09_289074	206	38	(	(	-LRB-
10_1101-2020_09_09_289074	206	39	in	in	IN
10_1101-2020_09_09_289074	206	40	Å	å	NN
10_1101-2020_09_09_289074	206	41	)	)	-RRB-
10_1101-2020_09_09_289074	206	42	computed	compute	VBD
10_1101-2020_09_09_289074	206	43	on	on	IN
10_1101-2020_09_09_289074	206	44	structures	structure	NNS
10_1101-2020_09_09_289074	206	45	aligned	align	VBN
10_1101-2020_09_09_289074	206	46	without	without	IN
10_1101-2020_09_09_289074	206	47	hydrogen	hydrogen	NN
10_1101-2020_09_09_289074	206	48	atoms	atom	NNS
10_1101-2020_09_09_289074	206	49	.	.	.
10_1101-2020_09_09_289074	207	1	0,00	0,00	NNP
10_1101-2020_09_09_289074	207	2	0,34	0,34	CD
10_1101-2020_09_09_289074	207	3	1,43	1,43	CD
10_1101-2020_09_09_289074	207	4	2,19	2,19	CD
10_1101-2020_09_09_289074	207	5	0,34	0,34	CD
10_1101-2020_09_09_289074	207	6	0,00	0,00	CD
10_1101-2020_09_09_289074	207	7	1,40	1,40	CD
10_1101-2020_09_09_289074	207	8	2,18	2,18	CD
10_1101-2020_09_09_289074	207	9	1,43	1,43	CD
10_1101-2020_09_09_289074	207	10	1,40	1,40	CD
10_1101-2020_09_09_289074	207	11	0,00	0,00	CD
10_1101-2020_09_09_289074	207	12	1,48	1,48	CD
10_1101-2020_09_09_289074	207	13	2,19	2,19	CD
10_1101-2020_09_09_289074	207	14	2,18	2,18	CD
10_1101-2020_09_09_289074	207	15	1,48	1,48	CD
10_1101-2020_09_09_289074	207	16	0,00	0,00	CD
10_1101-2020_09_09_289074	207	17	0,00	0,00	CD
10_1101-2020_09_09_289074	207	18	0,50	0,50	CD
10_1101-2020_09_09_289074	207	19	1,00	1,00	CD
10_1101-2020_09_09_289074	207	20	1,50	1,50	CD
10_1101-2020_09_09_289074	207	21	2,00	2,00	CD
10_1101-2020_09_09_289074	207	22	2,50	2,50	CD
10_1101-2020_09_09_289074	207	23	6LZG	6lzg	NN
10_1101-2020_09_09_289074	207	24	6M0J	6m0j	CD
10_1101-2020_09_09_289074	207	25	6VW1-A	6vw1-a	NN
10_1101-2020_09_09_289074	207	26	6VW1-B	6vw1-b	CD
10_1101-2020_09_09_289074	207	27	R	r	NN
10_1101-2020_09_09_289074	207	28	M	m	NN
10_1101-2020_09_09_289074	207	29	S	s	NN
10_1101-2020_09_09_289074	207	30	d	d	NN
10_1101-2020_09_09_289074	207	31	(	(	-LRB-
10_1101-2020_09_09_289074	207	32	Å	å	NN
10_1101-2020_09_09_289074	207	33	)	)	-RRB-
10_1101-2020_09_09_289074	207	34	PDB	PDB	NNP
10_1101-2020_09_09_289074	207	35	entries	entrie	VBZ
10_1101-2020_09_09_289074	207	36	6LZG	6lzg	NN
10_1101-2020_09_09_289074	207	37	6M0J	6m0j	CD
10_1101-2020_09_09_289074	207	38	6VW1-A	6vw1-a	NN
10_1101-2020_09_09_289074	207	39	6VW1-BB	6vw1-bb	CD
10_1101-2020_09_09_289074	207	40	A	a	NN
10_1101-2020_09_09_289074	207	41	.CC	.CC	:
10_1101-2020_09_09_289074	207	42	-	-	HYPH
10_1101-2020_09_09_289074	207	43	BY	by	IN
10_1101-2020_09_09_289074	207	44	-	-	HYPH
10_1101-2020_09_09_289074	207	45	NC	NC	NNP
10_1101-2020_09_09_289074	207	46	-	-	HYPH
10_1101-2020_09_09_289074	207	47	ND	ND	NNP
10_1101-2020_09_09_289074	207	48	4.0	4.0	CD
10_1101-2020_09_09_289074	207	49	International	International	NNP
10_1101-2020_09_09_289074	207	50	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	207	51	under	under	IN
10_1101-2020_09_09_289074	207	52	a	a	DT
10_1101-2020_09_09_289074	207	53	(	(	-LRB-
10_1101-2020_09_09_289074	207	54	which	which	WDT
10_1101-2020_09_09_289074	207	55	was	be	VBD
10_1101-2020_09_09_289074	207	56	not	not	RB
10_1101-2020_09_09_289074	207	57	certified	certify	VBN
10_1101-2020_09_09_289074	207	58	by	by	IN
10_1101-2020_09_09_289074	207	59	peer	peer	NN
10_1101-2020_09_09_289074	207	60	review	review	NN
10_1101-2020_09_09_289074	207	61	)	)	-RRB-
10_1101-2020_09_09_289074	207	62	is	be	VBZ
10_1101-2020_09_09_289074	207	63	the	the	DT
10_1101-2020_09_09_289074	207	64	author	author	NN
10_1101-2020_09_09_289074	207	65	/	/	SYM
10_1101-2020_09_09_289074	207	66	funder	funder	NN
10_1101-2020_09_09_289074	207	67	,	,	,
10_1101-2020_09_09_289074	207	68	who	who	WP
10_1101-2020_09_09_289074	207	69	has	have	VBZ
10_1101-2020_09_09_289074	207	70	granted	grant	VBN
10_1101-2020_09_09_289074	207	71	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	207	72	a	a	DT
10_1101-2020_09_09_289074	207	73	license	license	NN
10_1101-2020_09_09_289074	207	74	to	to	TO
10_1101-2020_09_09_289074	207	75	display	display	VB
10_1101-2020_09_09_289074	207	76	the	the	DT
10_1101-2020_09_09_289074	207	77	preprint	preprint	NN
10_1101-2020_09_09_289074	207	78	in	in	IN
10_1101-2020_09_09_289074	207	79	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	207	80	.	.	.
10_1101-2020_09_09_289074	208	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	208	2	is	be	VBZ
10_1101-2020_09_09_289074	208	3	made	make	VBN
10_1101-2020_09_09_289074	208	4	The	the	DT
10_1101-2020_09_09_289074	208	5	copyright	copyright	NN
10_1101-2020_09_09_289074	208	6	holder	holder	NN
10_1101-2020_09_09_289074	208	7	for	for	IN
10_1101-2020_09_09_289074	208	8	this	this	DT
10_1101-2020_09_09_289074	208	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	208	10	version	version	NN
10_1101-2020_09_09_289074	208	11	posted	post	VBD
10_1101-2020_09_09_289074	208	12	January	January	NNP
10_1101-2020_09_09_289074	208	13	5	5	CD
10_1101-2020_09_09_289074	208	14	,	,	,
10_1101-2020_09_09_289074	208	15	2021	2021	CD
10_1101-2020_09_09_289074	208	16	.	.	.
10_1101-2020_09_09_289074	208	17	;	;	:
10_1101-2020_09_09_289074	208	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	208	19	:	:	:
10_1101-2020_09_09_289074	208	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	208	21	preprint	preprint	NN
10_1101-2020_09_09_289074	208	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	208	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	208	24	14	14	CD
10_1101-2020_09_09_289074	208	25	Figure	figure	NN
10_1101-2020_09_09_289074	208	26	2	2	CD
10_1101-2020_09_09_289074	208	27	.	.	.
10_1101-2020_09_09_289074	209	1	Summary	summary	NN
10_1101-2020_09_09_289074	209	2	of	of	IN
10_1101-2020_09_09_289074	209	3	the	the	DT
10_1101-2020_09_09_289074	209	4	pipeline	pipeline	NN
10_1101-2020_09_09_289074	209	5	adopted	adopt	VBN
10_1101-2020_09_09_289074	209	6	by	by	IN
10_1101-2020_09_09_289074	209	7	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	209	8	to	to	TO
10_1101-2020_09_09_289074	209	9	identify	identify	VB
10_1101-2020_09_09_289074	209	10	key	key	JJ
10_1101-2020_09_09_289074	209	11	residues	residue	NNS
10_1101-2020_09_09_289074	209	12	contributing	contribute	VBG
10_1101-2020_09_09_289074	209	13	to	to	IN
10_1101-2020_09_09_289074	209	14	the	the	DT
10_1101-2020_09_09_289074	209	15	SARS	SARS	NNP
10_1101-2020_09_09_289074	209	16	-	-	HYPH
10_1101-2020_09_09_289074	209	17	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	209	18	Spike	Spike	NNP
10_1101-2020_09_09_289074	209	19	/	/	SYM
10_1101-2020_09_09_289074	209	20	Human	Human	NNP
10_1101-2020_09_09_289074	209	21	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	209	22	interface	interface	NN
10_1101-2020_09_09_289074	209	23	.	.	.
10_1101-2020_09_09_289074	210	1	Spike	Spike	NNP
10_1101-2020_09_09_289074	210	2	is	be	VBZ
10_1101-2020_09_09_289074	210	3	depicted	depict	VBN
10_1101-2020_09_09_289074	210	4	in	in	IN
10_1101-2020_09_09_289074	210	5	cyan	cyan	NNP
10_1101-2020_09_09_289074	210	6	,	,	,
10_1101-2020_09_09_289074	210	7	and	and	CC
10_1101-2020_09_09_289074	210	8	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	210	9	in	in	IN
10_1101-2020_09_09_289074	210	10	orange	orange	NN
10_1101-2020_09_09_289074	210	11	,	,	,
10_1101-2020_09_09_289074	210	12	based	base	VBN
10_1101-2020_09_09_289074	210	13	on	on	IN
10_1101-2020_09_09_289074	210	14	the	the	DT
10_1101-2020_09_09_289074	210	15	6LZG	6LZG	NNP
10_1101-2020_09_09_289074	210	16	PDB	PDB	NNP
10_1101-2020_09_09_289074	210	17	model	model	NN
10_1101-2020_09_09_289074	210	18	(	(	-LRB-
10_1101-2020_09_09_289074	210	19	10	10	CD
10_1101-2020_09_09_289074	210	20	)	)	-RRB-
10_1101-2020_09_09_289074	210	21	.	.	.
10_1101-2020_09_09_289074	211	1	Residues	residue	NNS
10_1101-2020_09_09_289074	211	2	highlighted	highlight	VBN
10_1101-2020_09_09_289074	211	3	by	by	IN
10_1101-2020_09_09_289074	211	4	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	211	5	are	be	VBP
10_1101-2020_09_09_289074	211	6	then	then	RB
10_1101-2020_09_09_289074	211	7	tested	test	VBN
10_1101-2020_09_09_289074	211	8	for	for	IN
10_1101-2020_09_09_289074	211	9	mutation	mutation	NN
10_1101-2020_09_09_289074	211	10	frequency	frequency	NN
10_1101-2020_09_09_289074	211	11	in	in	IN
10_1101-2020_09_09_289074	211	12	the	the	DT
10_1101-2020_09_09_289074	211	13	worldwide	worldwide	JJ
10_1101-2020_09_09_289074	211	14	SARS	SARS	NNP
10_1101-2020_09_09_289074	211	15	-	-	HYPH
10_1101-2020_09_09_289074	211	16	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	211	17	population	population	NN
10_1101-2020_09_09_289074	211	18	.	.	.
10_1101-2020_09_09_289074	212	1	.CC	.CC	NFP
10_1101-2020_09_09_289074	212	2	-	-	:
10_1101-2020_09_09_289074	212	3	BY	by	IN
10_1101-2020_09_09_289074	212	4	-	-	HYPH
10_1101-2020_09_09_289074	212	5	NC	NC	NNP
10_1101-2020_09_09_289074	212	6	-	-	HYPH
10_1101-2020_09_09_289074	212	7	ND	ND	NNP
10_1101-2020_09_09_289074	212	8	4.0	4.0	CD
10_1101-2020_09_09_289074	212	9	International	International	NNP
10_1101-2020_09_09_289074	212	10	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	212	11	under	under	IN
10_1101-2020_09_09_289074	212	12	a	a	DT
10_1101-2020_09_09_289074	212	13	(	(	-LRB-
10_1101-2020_09_09_289074	212	14	which	which	WDT
10_1101-2020_09_09_289074	212	15	was	be	VBD
10_1101-2020_09_09_289074	212	16	not	not	RB
10_1101-2020_09_09_289074	212	17	certified	certify	VBN
10_1101-2020_09_09_289074	212	18	by	by	IN
10_1101-2020_09_09_289074	212	19	peer	peer	NN
10_1101-2020_09_09_289074	212	20	review	review	NN
10_1101-2020_09_09_289074	212	21	)	)	-RRB-
10_1101-2020_09_09_289074	212	22	is	be	VBZ
10_1101-2020_09_09_289074	212	23	the	the	DT
10_1101-2020_09_09_289074	212	24	author	author	NN
10_1101-2020_09_09_289074	212	25	/	/	SYM
10_1101-2020_09_09_289074	212	26	funder	funder	NN
10_1101-2020_09_09_289074	212	27	,	,	,
10_1101-2020_09_09_289074	212	28	who	who	WP
10_1101-2020_09_09_289074	212	29	has	have	VBZ
10_1101-2020_09_09_289074	212	30	granted	grant	VBN
10_1101-2020_09_09_289074	212	31	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	212	32	a	a	DT
10_1101-2020_09_09_289074	212	33	license	license	NN
10_1101-2020_09_09_289074	212	34	to	to	TO
10_1101-2020_09_09_289074	212	35	display	display	VB
10_1101-2020_09_09_289074	212	36	the	the	DT
10_1101-2020_09_09_289074	212	37	preprint	preprint	NN
10_1101-2020_09_09_289074	212	38	in	in	IN
10_1101-2020_09_09_289074	212	39	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	212	40	.	.	.
10_1101-2020_09_09_289074	213	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	213	2	is	be	VBZ
10_1101-2020_09_09_289074	213	3	made	make	VBN
10_1101-2020_09_09_289074	213	4	The	the	DT
10_1101-2020_09_09_289074	213	5	copyright	copyright	NN
10_1101-2020_09_09_289074	213	6	holder	holder	NN
10_1101-2020_09_09_289074	213	7	for	for	IN
10_1101-2020_09_09_289074	213	8	this	this	DT
10_1101-2020_09_09_289074	213	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	213	10	version	version	NN
10_1101-2020_09_09_289074	213	11	posted	post	VBD
10_1101-2020_09_09_289074	213	12	January	January	NNP
10_1101-2020_09_09_289074	213	13	5	5	CD
10_1101-2020_09_09_289074	213	14	,	,	,
10_1101-2020_09_09_289074	213	15	2021	2021	CD
10_1101-2020_09_09_289074	213	16	.	.	.
10_1101-2020_09_09_289074	213	17	;	;	:
10_1101-2020_09_09_289074	213	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	213	19	:	:	:
10_1101-2020_09_09_289074	213	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	213	21	preprint	preprint	NN
10_1101-2020_09_09_289074	213	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	213	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	213	24	15	15	CD
10_1101-2020_09_09_289074	213	25	Figure	figure	NN
10_1101-2020_09_09_289074	213	26	3	3	CD
10_1101-2020_09_09_289074	213	27	.	.	.
10_1101-2020_09_09_289074	214	1	3D	3D	NNP
10_1101-2020_09_09_289074	214	2	ribbon	ribbon	NNP
10_1101-2020_09_09_289074	214	3	representation	representation	NN
10_1101-2020_09_09_289074	214	4	of	of	IN
10_1101-2020_09_09_289074	214	5	the	the	DT
10_1101-2020_09_09_289074	214	6	interaction	interaction	NN
10_1101-2020_09_09_289074	214	7	domains	domain	NNS
10_1101-2020_09_09_289074	214	8	of	of	IN
10_1101-2020_09_09_289074	214	9	SARS	SARS	NNP
10_1101-2020_09_09_289074	214	10	-	-	HYPH
10_1101-2020_09_09_289074	214	11	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	214	12	Spike	Spike	NNP
10_1101-2020_09_09_289074	214	13	(	(	-LRB-
10_1101-2020_09_09_289074	214	14	left	left	JJ
10_1101-2020_09_09_289074	214	15	,	,	,
10_1101-2020_09_09_289074	214	16	orange	orange	NNP
10_1101-2020_09_09_289074	214	17	)	)	-RRB-
10_1101-2020_09_09_289074	214	18	and	and	CC
10_1101-2020_09_09_289074	214	19	human	human	JJ
10_1101-2020_09_09_289074	214	20	ACE2	ACE2	NNS
10_1101-2020_09_09_289074	214	21	(	(	-LRB-
10_1101-2020_09_09_289074	214	22	right	right	UH
10_1101-2020_09_09_289074	214	23	,	,	,
10_1101-2020_09_09_289074	214	24	green	green	JJ
10_1101-2020_09_09_289074	214	25	)	)	-RRB-
10_1101-2020_09_09_289074	214	26	,	,	,
10_1101-2020_09_09_289074	214	27	based	base	VBN
10_1101-2020_09_09_289074	214	28	on	on	IN
10_1101-2020_09_09_289074	214	29	the	the	DT
10_1101-2020_09_09_289074	214	30	crystal	crystal	NN
10_1101-2020_09_09_289074	214	31	structure	structure	NN
10_1101-2020_09_09_289074	214	32	6LZG	6LZG	NNP
10_1101-2020_09_09_289074	214	33	deposited	deposit	VBD
10_1101-2020_09_09_289074	214	34	on	on	IN
10_1101-2020_09_09_289074	214	35	Protein	Protein	NNP
10_1101-2020_09_09_289074	214	36	Data	Data	NNPS
10_1101-2020_09_09_289074	214	37	Bank	Bank	NNP
10_1101-2020_09_09_289074	214	38	and	and	CC
10_1101-2020_09_09_289074	214	39	produced	produce	VBN
10_1101-2020_09_09_289074	214	40	by	by	IN
10_1101-2020_09_09_289074	214	41	(	(	-LRB-
10_1101-2020_09_09_289074	214	42	10	10	CD
10_1101-2020_09_09_289074	214	43	)	)	-RRB-
10_1101-2020_09_09_289074	214	44	.	.	.
10_1101-2020_09_09_289074	215	1	The	the	DT
10_1101-2020_09_09_289074	215	2	positions	position	NNS
10_1101-2020_09_09_289074	215	3	of	of	IN
10_1101-2020_09_09_289074	215	4	the	the	DT
10_1101-2020_09_09_289074	215	5	three	three	CD
10_1101-2020_09_09_289074	215	6	most	most	RBS
10_1101-2020_09_09_289074	215	7	frequent	frequent	JJ
10_1101-2020_09_09_289074	215	8	Spike	Spike	NNP
10_1101-2020_09_09_289074	215	9	mutations	mutation	NNS
10_1101-2020_09_09_289074	215	10	in	in	IN
10_1101-2020_09_09_289074	215	11	the	the	DT
10_1101-2020_09_09_289074	215	12	interacting	interacting	NN
10_1101-2020_09_09_289074	215	13	region	region	NN
10_1101-2020_09_09_289074	215	14	(	(	-LRB-
10_1101-2020_09_09_289074	215	15	AA	AA	NNP
10_1101-2020_09_09_289074	215	16	350	350	CD
10_1101-2020_09_09_289074	215	17	-	-	HYPH
10_1101-2020_09_09_289074	215	18	550	550	CD
10_1101-2020_09_09_289074	215	19	)	)	-RRB-
10_1101-2020_09_09_289074	215	20	with	with	IN
10_1101-2020_09_09_289074	215	21	a	a	DT
10_1101-2020_09_09_289074	215	22	non	non	JJ
10_1101-2020_09_09_289074	215	23	-	-	JJ
10_1101-2020_09_09_289074	215	24	zero	zero	CD
10_1101-2020_09_09_289074	215	25	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	215	26	score	score	NN
10_1101-2020_09_09_289074	215	27	are	be	VBP
10_1101-2020_09_09_289074	215	28	indicated	indicate	VBN
10_1101-2020_09_09_289074	215	29	:	:	:
10_1101-2020_09_09_289074	215	30	N439	N439	NNP
10_1101-2020_09_09_289074	215	31	K	K	NNP
10_1101-2020_09_09_289074	215	32	,	,	,
10_1101-2020_09_09_289074	215	33	N501Y	N501Y	NNP
10_1101-2020_09_09_289074	215	34	and	and	CC
10_1101-2020_09_09_289074	215	35	S477N.	s477n.	ADD
10_1101-2020_09_09_289074	216	1	.CC	.CC	NFP
10_1101-2020_09_09_289074	216	2	-	-	:
10_1101-2020_09_09_289074	216	3	BY	by	IN
10_1101-2020_09_09_289074	216	4	-	-	HYPH
10_1101-2020_09_09_289074	216	5	NC	NC	NNP
10_1101-2020_09_09_289074	216	6	-	-	HYPH
10_1101-2020_09_09_289074	216	7	ND	ND	NNP
10_1101-2020_09_09_289074	216	8	4.0	4.0	CD
10_1101-2020_09_09_289074	216	9	International	International	NNP
10_1101-2020_09_09_289074	216	10	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	216	11	under	under	IN
10_1101-2020_09_09_289074	216	12	a	a	DT
10_1101-2020_09_09_289074	216	13	(	(	-LRB-
10_1101-2020_09_09_289074	216	14	which	which	WDT
10_1101-2020_09_09_289074	216	15	was	be	VBD
10_1101-2020_09_09_289074	216	16	not	not	RB
10_1101-2020_09_09_289074	216	17	certified	certify	VBN
10_1101-2020_09_09_289074	216	18	by	by	IN
10_1101-2020_09_09_289074	216	19	peer	peer	NN
10_1101-2020_09_09_289074	216	20	review	review	NN
10_1101-2020_09_09_289074	216	21	)	)	-RRB-
10_1101-2020_09_09_289074	216	22	is	be	VBZ
10_1101-2020_09_09_289074	216	23	the	the	DT
10_1101-2020_09_09_289074	216	24	author	author	NN
10_1101-2020_09_09_289074	216	25	/	/	SYM
10_1101-2020_09_09_289074	216	26	funder	funder	NN
10_1101-2020_09_09_289074	216	27	,	,	,
10_1101-2020_09_09_289074	216	28	who	who	WP
10_1101-2020_09_09_289074	216	29	has	have	VBZ
10_1101-2020_09_09_289074	216	30	granted	grant	VBN
10_1101-2020_09_09_289074	216	31	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	216	32	a	a	DT
10_1101-2020_09_09_289074	216	33	license	license	NN
10_1101-2020_09_09_289074	216	34	to	to	TO
10_1101-2020_09_09_289074	216	35	display	display	VB
10_1101-2020_09_09_289074	216	36	the	the	DT
10_1101-2020_09_09_289074	216	37	preprint	preprint	NN
10_1101-2020_09_09_289074	216	38	in	in	IN
10_1101-2020_09_09_289074	216	39	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	216	40	.	.	.
10_1101-2020_09_09_289074	217	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	217	2	is	be	VBZ
10_1101-2020_09_09_289074	217	3	made	make	VBN
10_1101-2020_09_09_289074	217	4	The	the	DT
10_1101-2020_09_09_289074	217	5	copyright	copyright	NN
10_1101-2020_09_09_289074	217	6	holder	holder	NN
10_1101-2020_09_09_289074	217	7	for	for	IN
10_1101-2020_09_09_289074	217	8	this	this	DT
10_1101-2020_09_09_289074	217	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	217	10	version	version	NN
10_1101-2020_09_09_289074	217	11	posted	post	VBD
10_1101-2020_09_09_289074	217	12	January	January	NNP
10_1101-2020_09_09_289074	217	13	5	5	CD
10_1101-2020_09_09_289074	217	14	,	,	,
10_1101-2020_09_09_289074	217	15	2021	2021	CD
10_1101-2020_09_09_289074	217	16	.	.	.
10_1101-2020_09_09_289074	217	17	;	;	:
10_1101-2020_09_09_289074	217	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	217	19	:	:	:
10_1101-2020_09_09_289074	217	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	217	21	preprint	preprint	NN
10_1101-2020_09_09_289074	217	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	217	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	217	24	16	16	CD
10_1101-2020_09_09_289074	217	25	Figure	Figure	NNP
10_1101-2020_09_09_289074	217	26	4	4	CD
10_1101-2020_09_09_289074	217	27	.	.	.
10_1101-2020_09_09_289074	218	1	(	(	-LRB-
10_1101-2020_09_09_289074	218	2	A	a	DT
10_1101-2020_09_09_289074	218	3	)	)	-RRB-
10_1101-2020_09_09_289074	218	4	Occurrence	Occurrence	NNP
10_1101-2020_09_09_289074	218	5	of	of	IN
10_1101-2020_09_09_289074	218	6	AA	AA	NNP
10_1101-2020_09_09_289074	218	7	-	-	HYPH
10_1101-2020_09_09_289074	218	8	changing	change	VBG
10_1101-2020_09_09_289074	218	9	variants	variant	NNS
10_1101-2020_09_09_289074	218	10	on	on	IN
10_1101-2020_09_09_289074	218	11	SARS	SARS	NNP
10_1101-2020_09_09_289074	218	12	-	-	HYPH
10_1101-2020_09_09_289074	218	13	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	218	14	Spike	Spike	NNP
10_1101-2020_09_09_289074	218	15	protein	protein	NN
10_1101-2020_09_09_289074	218	16	.	.	.
10_1101-2020_09_09_289074	219	1	X	X	NNS
10_1101-2020_09_09_289074	219	2	-	-	NN
10_1101-2020_09_09_289074	219	3	axis	axis	RB
10_1101-2020_09_09_289074	219	4	indicates	indicate	VBZ
10_1101-2020_09_09_289074	219	5	the	the	DT
10_1101-2020_09_09_289074	219	6	position	position	NN
10_1101-2020_09_09_289074	219	7	of	of	IN
10_1101-2020_09_09_289074	219	8	the	the	DT
10_1101-2020_09_09_289074	219	9	affected	affected	JJ
10_1101-2020_09_09_289074	219	10	AA	AA	NNP
10_1101-2020_09_09_289074	219	11	.	.	.
10_1101-2020_09_09_289074	220	1	Y	Y	NNP
10_1101-2020_09_09_289074	220	2	-	-	HYPH
10_1101-2020_09_09_289074	220	3	axis	axis	NNP
10_1101-2020_09_09_289074	220	4	indicates	indicate	VBZ
10_1101-2020_09_09_289074	220	5	the	the	DT
10_1101-2020_09_09_289074	220	6	log10	log10	NNS
10_1101-2020_09_09_289074	220	7	of	of	IN
10_1101-2020_09_09_289074	220	8	the	the	DT
10_1101-2020_09_09_289074	220	9	number	number	NN
10_1101-2020_09_09_289074	220	10	of	of	IN
10_1101-2020_09_09_289074	220	11	occurrences	occurrence	NNS
10_1101-2020_09_09_289074	220	12	of	of	IN
10_1101-2020_09_09_289074	220	13	the	the	DT
10_1101-2020_09_09_289074	220	14	variant	variant	NN
10_1101-2020_09_09_289074	220	15	in	in	IN
10_1101-2020_09_09_289074	220	16	the	the	DT
10_1101-2020_09_09_289074	220	17	SARS	SARS	NNP
10_1101-2020_09_09_289074	220	18	-	-	HYPH
10_1101-2020_09_09_289074	220	19	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	220	20	dataset	dataset	NN
10_1101-2020_09_09_289074	220	21	.	.	.
10_1101-2020_09_09_289074	221	1	Labels	label	NNS
10_1101-2020_09_09_289074	221	2	indicate	indicate	VBP
10_1101-2020_09_09_289074	221	3	variants	variant	NNS
10_1101-2020_09_09_289074	221	4	affecting	affect	VBG
10_1101-2020_09_09_289074	221	5	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	221	6	/	/	SYM
10_1101-2020_09_09_289074	221	7	Spike	Spike	NNP
10_1101-2020_09_09_289074	221	8	binding	bind	VBG
10_1101-2020_09_09_289074	221	9	and	and	CC
10_1101-2020_09_09_289074	221	10	detected	detect	VBD
10_1101-2020_09_09_289074	221	11	in	in	IN
10_1101-2020_09_09_289074	221	12	at	at	RB
10_1101-2020_09_09_289074	221	13	least	least	RBS
10_1101-2020_09_09_289074	221	14	5	5	CD
10_1101-2020_09_09_289074	221	15	SARS	SARS	NNP
10_1101-2020_09_09_289074	221	16	-	-	HYPH
10_1101-2020_09_09_289074	221	17	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	221	18	sequences	sequence	NNS
10_1101-2020_09_09_289074	221	19	.	.	.
10_1101-2020_09_09_289074	222	1	Vertical	vertical	JJ
10_1101-2020_09_09_289074	222	2	dashed	dash	VBN
10_1101-2020_09_09_289074	222	3	lines	line	NNS
10_1101-2020_09_09_289074	222	4	indicate	indicate	VBP
10_1101-2020_09_09_289074	222	5	crystalized	crystalized	JJ
10_1101-2020_09_09_289074	222	6	region	region	NN
10_1101-2020_09_09_289074	222	7	analyzed	analyze	VBN
10_1101-2020_09_09_289074	222	8	(	(	-LRB-
10_1101-2020_09_09_289074	222	9	aa	aa	NNP
10_1101-2020_09_09_289074	222	10	330	330	CD
10_1101-2020_09_09_289074	222	11	–	–	:
10_1101-2020_09_09_289074	222	12	530	530	CD
10_1101-2020_09_09_289074	222	13	)	)	-RRB-
10_1101-2020_09_09_289074	222	14	.	.	.
10_1101-2020_09_09_289074	223	1	The	the	DT
10_1101-2020_09_09_289074	223	2	D614	D614	NNP
10_1101-2020_09_09_289074	223	3	G	G	NNP
10_1101-2020_09_09_289074	223	4	variant	variant	NN
10_1101-2020_09_09_289074	223	5	,	,	,
10_1101-2020_09_09_289074	223	6	located	locate	VBN
10_1101-2020_09_09_289074	223	7	outside	outside	IN
10_1101-2020_09_09_289074	223	8	the	the	DT
10_1101-2020_09_09_289074	223	9	RBD	RBD	NNP
10_1101-2020_09_09_289074	223	10	,	,	,
10_1101-2020_09_09_289074	223	11	is	be	VBZ
10_1101-2020_09_09_289074	223	12	also	also	RB
10_1101-2020_09_09_289074	223	13	indicated	indicate	VBN
10_1101-2020_09_09_289074	223	14	.	.	.
10_1101-2020_09_09_289074	224	1	(	(	-LRB-
10_1101-2020_09_09_289074	224	2	B	b	NN
10_1101-2020_09_09_289074	224	3	)	)	-RRB-
10_1101-2020_09_09_289074	224	4	Scatter	scatter	NN
10_1101-2020_09_09_289074	224	5	plot	plot	NN
10_1101-2020_09_09_289074	224	6	indicating	indicate	VBG
10_1101-2020_09_09_289074	224	7	the	the	DT
10_1101-2020_09_09_289074	224	8	occurrence	occurrence	NN
10_1101-2020_09_09_289074	224	9	of	of	IN
10_1101-2020_09_09_289074	224	10	the	the	DT
10_1101-2020_09_09_289074	224	11	variant	variant	NN
10_1101-2020_09_09_289074	224	12	in	in	IN
10_1101-2020_09_09_289074	224	13	the	the	DT
10_1101-2020_09_09_289074	224	14	population	population	NN
10_1101-2020_09_09_289074	224	15	(	(	-LRB-
10_1101-2020_09_09_289074	224	16	x	x	SYM
10_1101-2020_09_09_289074	224	17	-	-	:
10_1101-2020_09_09_289074	224	18	axis	axis	NNP
10_1101-2020_09_09_289074	224	19	)	)	-RRB-
10_1101-2020_09_09_289074	224	20	and	and	CC
10_1101-2020_09_09_289074	224	21	the	the	DT
10_1101-2020_09_09_289074	224	22	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	224	23	score	score	NN
10_1101-2020_09_09_289074	224	24	of	of	IN
10_1101-2020_09_09_289074	224	25	the	the	DT
10_1101-2020_09_09_289074	224	26	reference	reference	NN
10_1101-2020_09_09_289074	224	27	AA	AA	NNP
10_1101-2020_09_09_289074	224	28	in	in	IN
10_1101-2020_09_09_289074	224	29	the	the	DT
10_1101-2020_09_09_289074	224	30	model	model	NN
10_1101-2020_09_09_289074	224	31	(	(	-LRB-
10_1101-2020_09_09_289074	224	32	y	y	NNP
10_1101-2020_09_09_289074	224	33	-	-	HYPH
10_1101-2020_09_09_289074	224	34	axis	axis	NNP
10_1101-2020_09_09_289074	224	35	)	)	-RRB-
10_1101-2020_09_09_289074	224	36	.	.	.
10_1101-2020_09_09_289074	225	1	Mutations	mutation	NNS
10_1101-2020_09_09_289074	225	2	with	with	IN
10_1101-2020_09_09_289074	225	3	non	non	JJ
10_1101-2020_09_09_289074	225	4	-	-	JJ
10_1101-2020_09_09_289074	225	5	zero	zero	CD
10_1101-2020_09_09_289074	225	6	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	225	7	score	score	NN
10_1101-2020_09_09_289074	225	8	are	be	VBP
10_1101-2020_09_09_289074	225	9	indicated	indicate	VBN
10_1101-2020_09_09_289074	225	10	.	.	.
10_1101-2020_09_09_289074	226	1	CC	CC	NNP
10_1101-2020_09_09_289074	226	2	indicates	indicate	VBZ
10_1101-2020_09_09_289074	226	3	the	the	DT
10_1101-2020_09_09_289074	226	4	Pearson	Pearson	NNP
10_1101-2020_09_09_289074	226	5	correlation	correlation	NN
10_1101-2020_09_09_289074	226	6	coefficient	coefficient	NN
10_1101-2020_09_09_289074	226	7	and	and	CC
10_1101-2020_09_09_289074	226	8	p	p	NN
10_1101-2020_09_09_289074	226	9	indicates	indicate	VBZ
10_1101-2020_09_09_289074	226	10	the	the	DT
10_1101-2020_09_09_289074	226	11	p	p	NN
10_1101-2020_09_09_289074	226	12	-	-	HYPH
10_1101-2020_09_09_289074	226	13	value	value	NN
10_1101-2020_09_09_289074	226	14	of	of	IN
10_1101-2020_09_09_289074	226	15	the	the	DT
10_1101-2020_09_09_289074	226	16	CC	cc	NN
10_1101-2020_09_09_289074	226	17	.	.	.
10_1101-2020_09_09_289074	227	1	.CC	.CC	NFP
10_1101-2020_09_09_289074	227	2	-	-	:
10_1101-2020_09_09_289074	227	3	BY	by	IN
10_1101-2020_09_09_289074	227	4	-	-	HYPH
10_1101-2020_09_09_289074	227	5	NC	NC	NNP
10_1101-2020_09_09_289074	227	6	-	-	HYPH
10_1101-2020_09_09_289074	227	7	ND	ND	NNP
10_1101-2020_09_09_289074	227	8	4.0	4.0	CD
10_1101-2020_09_09_289074	227	9	International	International	NNP
10_1101-2020_09_09_289074	227	10	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	227	11	under	under	IN
10_1101-2020_09_09_289074	227	12	a	a	DT
10_1101-2020_09_09_289074	227	13	(	(	-LRB-
10_1101-2020_09_09_289074	227	14	which	which	WDT
10_1101-2020_09_09_289074	227	15	was	be	VBD
10_1101-2020_09_09_289074	227	16	not	not	RB
10_1101-2020_09_09_289074	227	17	certified	certify	VBN
10_1101-2020_09_09_289074	227	18	by	by	IN
10_1101-2020_09_09_289074	227	19	peer	peer	NN
10_1101-2020_09_09_289074	227	20	review	review	NN
10_1101-2020_09_09_289074	227	21	)	)	-RRB-
10_1101-2020_09_09_289074	227	22	is	be	VBZ
10_1101-2020_09_09_289074	227	23	the	the	DT
10_1101-2020_09_09_289074	227	24	author	author	NN
10_1101-2020_09_09_289074	227	25	/	/	SYM
10_1101-2020_09_09_289074	227	26	funder	funder	NN
10_1101-2020_09_09_289074	227	27	,	,	,
10_1101-2020_09_09_289074	227	28	who	who	WP
10_1101-2020_09_09_289074	227	29	has	have	VBZ
10_1101-2020_09_09_289074	227	30	granted	grant	VBN
10_1101-2020_09_09_289074	227	31	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	227	32	a	a	DT
10_1101-2020_09_09_289074	227	33	license	license	NN
10_1101-2020_09_09_289074	227	34	to	to	TO
10_1101-2020_09_09_289074	227	35	display	display	VB
10_1101-2020_09_09_289074	227	36	the	the	DT
10_1101-2020_09_09_289074	227	37	preprint	preprint	NN
10_1101-2020_09_09_289074	227	38	in	in	IN
10_1101-2020_09_09_289074	227	39	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	227	40	.	.	.
10_1101-2020_09_09_289074	228	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	228	2	is	be	VBZ
10_1101-2020_09_09_289074	228	3	made	make	VBN
10_1101-2020_09_09_289074	228	4	The	the	DT
10_1101-2020_09_09_289074	228	5	copyright	copyright	NN
10_1101-2020_09_09_289074	228	6	holder	holder	NN
10_1101-2020_09_09_289074	228	7	for	for	IN
10_1101-2020_09_09_289074	228	8	this	this	DT
10_1101-2020_09_09_289074	228	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	228	10	version	version	NN
10_1101-2020_09_09_289074	228	11	posted	post	VBD
10_1101-2020_09_09_289074	228	12	January	January	NNP
10_1101-2020_09_09_289074	228	13	5	5	CD
10_1101-2020_09_09_289074	228	14	,	,	,
10_1101-2020_09_09_289074	228	15	2021	2021	CD
10_1101-2020_09_09_289074	228	16	.	.	.
10_1101-2020_09_09_289074	228	17	;	;	:
10_1101-2020_09_09_289074	228	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	228	19	:	:	:
10_1101-2020_09_09_289074	228	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	228	21	preprint	preprint	NN
10_1101-2020_09_09_289074	228	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	228	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NNP
10_1101-2020_09_09_289074	228	24	Figure	Figure	NNP
10_1101-2020_09_09_289074	228	25	5	5	CD
10_1101-2020_09_09_289074	228	26	.	.	.
10_1101-2020_09_09_289074	229	1	Frequency	frequency	NN
10_1101-2020_09_09_289074	229	2	of	of	IN
10_1101-2020_09_09_289074	229	3	mutations	mutation	NNS
10_1101-2020_09_09_289074	229	4	on	on	IN
10_1101-2020_09_09_289074	229	5	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	229	6	.	.	.
10_1101-2020_09_09_289074	230	1	X	X	NNS
10_1101-2020_09_09_289074	230	2	-	-	NN
10_1101-2020_09_09_289074	230	3	axis	axis	RB
10_1101-2020_09_09_289074	230	4	indicates	indicate	VBZ
10_1101-2020_09_09_289074	230	5	the	the	DT
10_1101-2020_09_09_289074	230	6	AA	AA	NNP
10_1101-2020_09_09_289074	230	7	position	position	NN
10_1101-2020_09_09_289074	230	8	in	in	IN
10_1101-2020_09_09_289074	230	9	isoform	isoform	NN
10_1101-2020_09_09_289074	230	10	1	1	CD
10_1101-2020_09_09_289074	230	11	(	(	-LRB-
10_1101-2020_09_09_289074	230	12	UniProt	UniProt	NNP
10_1101-2020_09_09_289074	230	13	Q9BYF1	Q9BYF1	NNP
10_1101-2020_09_09_289074	230	14	-	-	HYPH
10_1101-2020_09_09_289074	230	15	1	1	CD
10_1101-2020_09_09_289074	230	16	)	)	-RRB-
10_1101-2020_09_09_289074	230	17	.	.	.
10_1101-2020_09_09_289074	231	1	Y	Y	NNP
10_1101-2020_09_09_289074	231	2	-	-	HYPH
10_1101-2020_09_09_289074	231	3	axis	axis	NNP
10_1101-2020_09_09_289074	231	4	indicates	indicate	VBZ
10_1101-2020_09_09_289074	231	5	the	the	DT
10_1101-2020_09_09_289074	231	6	allele	allele	NNP
10_1101-2020_09_09_289074	231	7	frequency	frequency	NN
10_1101-2020_09_09_289074	231	8	in	in	IN
10_1101-2020_09_09_289074	231	9	the	the	DT
10_1101-2020_09_09_289074	231	10	global	global	JJ
10_1101-2020_09_09_289074	231	11	population	population	NN
10_1101-2020_09_09_289074	231	12	according	accord	VBG
10_1101-2020_09_09_289074	231	13	to	to	IN
10_1101-2020_09_09_289074	231	14	the	the	DT
10_1101-2020_09_09_289074	231	15	GNOMA	GNOMA	NNP
10_1101-2020_09_09_289074	231	16	v3	v3	NN
10_1101-2020_09_09_289074	231	17	database	database	NN
10_1101-2020_09_09_289074	231	18	.	.	.
10_1101-2020_09_09_289074	232	1	Labels	label	NNS
10_1101-2020_09_09_289074	232	2	indicate	indicate	VBP
10_1101-2020_09_09_289074	232	3	AA	AA	NNP
10_1101-2020_09_09_289074	232	4	changes	change	NNS
10_1101-2020_09_09_289074	232	5	observed	observe	VBN
10_1101-2020_09_09_289074	232	6	in	in	IN
10_1101-2020_09_09_289074	232	7	the	the	DT
10_1101-2020_09_09_289074	232	8	human	human	JJ
10_1101-2020_09_09_289074	232	9	population	population	NN
10_1101-2020_09_09_289074	232	10	with	with	IN
10_1101-2020_09_09_289074	232	11	non	non	JJ
10_1101-2020_09_09_289074	232	12	-	-	JJ
10_1101-2020_09_09_289074	232	13	zero	zero	CD
10_1101-2020_09_09_289074	232	14	GBP	GBP	NNP
10_1101-2020_09_09_289074	232	15	average	average	JJ
10_1101-2020_09_09_289074	232	16	score	score	NN
10_1101-2020_09_09_289074	232	17	in	in	IN
10_1101-2020_09_09_289074	232	18	the	the	DT
10_1101-2020_09_09_289074	232	19	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	232	20	/	/	SYM
10_1101-2020_09_09_289074	232	21	Spike	Spike	NNP
10_1101-2020_09_09_289074	232	22	interaction	interaction	NN
10_1101-2020_09_09_289074	232	23	models	model	NNS
10_1101-2020_09_09_289074	232	24	.	.	.
10_1101-2020_09_09_289074	233	1	Vertical	vertical	JJ
10_1101-2020_09_09_289074	233	2	dashed	dash	VBN
10_1101-2020_09_09_289074	233	3	lines	line	NNS
10_1101-2020_09_09_289074	233	4	indicate	indicate	VBP
10_1101-2020_09_09_289074	233	5	the	the	DT
10_1101-2020_09_09_289074	233	6	crystaliz	crystaliz	JJ
10_1101-2020_09_09_289074	233	7	region	region	NN
10_1101-2020_09_09_289074	233	8	analyzed	analyze	VBN
10_1101-2020_09_09_289074	233	9	in	in	IN
10_1101-2020_09_09_289074	233	10	this	this	DT
10_1101-2020_09_09_289074	233	11	study	study	NN
10_1101-2020_09_09_289074	233	12	(	(	-LRB-
10_1101-2020_09_09_289074	233	13	aa	aa	NNP
10_1101-2020_09_09_289074	233	14	15	15	CD
10_1101-2020_09_09_289074	233	15	–	–	:
10_1101-2020_09_09_289074	233	16	615	615	CD
10_1101-2020_09_09_289074	233	17	)	)	-RRB-
10_1101-2020_09_09_289074	233	18	.	.	.
10_1101-2020_09_09_289074	234	1	17	17	CD
10_1101-2020_09_09_289074	234	2	i	-PRON-	PRP
10_1101-2020_09_09_289074	234	3	d	d	VBN
10_1101-2020_09_09_289074	234	4	AD	ad	NN
10_1101-2020_09_09_289074	234	5	PM	pm	NN
10_1101-2020_09_09_289074	234	6	ed	ed	NN
10_1101-2020_09_09_289074	234	7	.CC	.CC	NFP
10_1101-2020_09_09_289074	234	8	-	-	:
10_1101-2020_09_09_289074	234	9	BY	by	IN
10_1101-2020_09_09_289074	234	10	-	-	HYPH
10_1101-2020_09_09_289074	234	11	NC	NC	NNP
10_1101-2020_09_09_289074	234	12	-	-	HYPH
10_1101-2020_09_09_289074	234	13	ND	ND	NNP
10_1101-2020_09_09_289074	234	14	4.0	4.0	CD
10_1101-2020_09_09_289074	234	15	International	International	NNP
10_1101-2020_09_09_289074	234	16	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	234	17	under	under	IN
10_1101-2020_09_09_289074	234	18	a	a	DT
10_1101-2020_09_09_289074	234	19	(	(	-LRB-
10_1101-2020_09_09_289074	234	20	which	which	WDT
10_1101-2020_09_09_289074	234	21	was	be	VBD
10_1101-2020_09_09_289074	234	22	not	not	RB
10_1101-2020_09_09_289074	234	23	certified	certify	VBN
10_1101-2020_09_09_289074	234	24	by	by	IN
10_1101-2020_09_09_289074	234	25	peer	peer	NN
10_1101-2020_09_09_289074	234	26	review	review	NN
10_1101-2020_09_09_289074	234	27	)	)	-RRB-
10_1101-2020_09_09_289074	234	28	is	be	VBZ
10_1101-2020_09_09_289074	234	29	the	the	DT
10_1101-2020_09_09_289074	234	30	author	author	NN
10_1101-2020_09_09_289074	234	31	/	/	SYM
10_1101-2020_09_09_289074	234	32	funder	funder	NN
10_1101-2020_09_09_289074	234	33	,	,	,
10_1101-2020_09_09_289074	234	34	who	who	WP
10_1101-2020_09_09_289074	234	35	has	have	VBZ
10_1101-2020_09_09_289074	234	36	granted	grant	VBN
10_1101-2020_09_09_289074	234	37	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	234	38	a	a	DT
10_1101-2020_09_09_289074	234	39	license	license	NN
10_1101-2020_09_09_289074	234	40	to	to	TO
10_1101-2020_09_09_289074	234	41	display	display	VB
10_1101-2020_09_09_289074	234	42	the	the	DT
10_1101-2020_09_09_289074	234	43	preprint	preprint	NN
10_1101-2020_09_09_289074	234	44	in	in	IN
10_1101-2020_09_09_289074	234	45	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	234	46	.	.	.
10_1101-2020_09_09_289074	235	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	235	2	is	be	VBZ
10_1101-2020_09_09_289074	235	3	made	make	VBN
10_1101-2020_09_09_289074	235	4	The	the	DT
10_1101-2020_09_09_289074	235	5	copyright	copyright	NN
10_1101-2020_09_09_289074	235	6	holder	holder	NN
10_1101-2020_09_09_289074	235	7	for	for	IN
10_1101-2020_09_09_289074	235	8	this	this	DT
10_1101-2020_09_09_289074	235	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	235	10	version	version	NN
10_1101-2020_09_09_289074	235	11	posted	post	VBD
10_1101-2020_09_09_289074	235	12	January	January	NNP
10_1101-2020_09_09_289074	235	13	5	5	CD
10_1101-2020_09_09_289074	235	14	,	,	,
10_1101-2020_09_09_289074	235	15	2021	2021	CD
10_1101-2020_09_09_289074	235	16	.	.	.
10_1101-2020_09_09_289074	235	17	;	;	:
10_1101-2020_09_09_289074	235	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	235	19	:	:	:
10_1101-2020_09_09_289074	235	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	235	21	preprint	preprint	NN
10_1101-2020_09_09_289074	235	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	235	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	235	24	18	18	CD
10_1101-2020_09_09_289074	235	25	Table	table	NN
10_1101-2020_09_09_289074	235	26	1	1	CD
10_1101-2020_09_09_289074	235	27	.	.	.
10_1101-2020_09_09_289074	236	1	GBPM	gbpm	NN
10_1101-2020_09_09_289074	236	2	scores	score	NNS
10_1101-2020_09_09_289074	236	3	,	,	,
10_1101-2020_09_09_289074	236	4	average	average	JJ
10_1101-2020_09_09_289074	236	5	values	value	NNS
10_1101-2020_09_09_289074	236	6	,	,	,
10_1101-2020_09_09_289074	236	7	and	and	CC
10_1101-2020_09_09_289074	236	8	quartile	quartile	JJ
10_1101-2020_09_09_289074	236	9	distribution	distribution	NN
10_1101-2020_09_09_289074	236	10	of	of	IN
10_1101-2020_09_09_289074	236	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	236	12	relevant	relevant	JJ
10_1101-2020_09_09_289074	236	13	AAs	aa	NNS
10_1101-2020_09_09_289074	236	14	in	in	IN
10_1101-2020_09_09_289074	236	15	three	three	CD
10_1101-2020_09_09_289074	236	16	PDB	PDB	NNP
10_1101-2020_09_09_289074	236	17	models	model	NNS
10_1101-2020_09_09_289074	236	18	.	.	.
10_1101-2020_09_09_289074	237	1	GBPM	gbpm	NN
10_1101-2020_09_09_289074	237	2	scores	score	NNS
10_1101-2020_09_09_289074	237	3	and	and	CC
10_1101-2020_09_09_289074	237	4	average	average	JJ
10_1101-2020_09_09_289074	237	5	values	value	NNS
10_1101-2020_09_09_289074	237	6	are	be	VBP
10_1101-2020_09_09_289074	237	7	reported	report	VBN
10_1101-2020_09_09_289074	237	8	in	in	IN
10_1101-2020_09_09_289074	237	9	kcal	kcal	NNP
10_1101-2020_09_09_289074	237	10	/	/	SYM
10_1101-2020_09_09_289074	237	11	mol	mol	NN
10_1101-2020_09_09_289074	237	12	.	.	.
10_1101-2020_09_09_289074	238	1	Residue	Residue	NNP
10_1101-2020_09_09_289074	238	2	#	#	NN
10_1101-2020_09_09_289074	238	3	PDB	PDB	NNP
10_1101-2020_09_09_289074	238	4	entries	entrie	VBZ
10_1101-2020_09_09_289074	238	5	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	238	6	6LZG	6lzg	NN
10_1101-2020_09_09_289074	238	7	6M0J	6m0j	CD
10_1101-2020_09_09_289074	238	8	6VW1-A	6vw1-a	CD
10_1101-2020_09_09_289074	238	9	6VW1-B	6vw1-b	CD
10_1101-2020_09_09_289074	238	10	Average	average	JJ
10_1101-2020_09_09_289074	238	11	score	score	NN
10_1101-2020_09_09_289074	238	12	Quartile	Quartile	NNP
10_1101-2020_09_09_289074	238	13	LYS	LYS	NNP
10_1101-2020_09_09_289074	238	14	417	417	CD
10_1101-2020_09_09_289074	238	15	-43.58	-43.58	:
10_1101-2020_09_09_289074	238	16	-12.12	-12.12	CD
10_1101-2020_09_09_289074	238	17	0.00	0.00	CD
10_1101-2020_09_09_289074	238	18	0.00	0.00	CD
10_1101-2020_09_09_289074	238	19	-13.93	-13.93	NFP
10_1101-2020_09_09_289074	238	20	Q2	q2	NN
10_1101-2020_09_09_289074	238	21	ASN	asn	NN
10_1101-2020_09_09_289074	238	22	439	439	CD
10_1101-2020_09_09_289074	238	23	0.00	0.00	CD
10_1101-2020_09_09_289074	238	24	0.00	0.00	CD
10_1101-2020_09_09_289074	238	25	-12.30	-12.30	NN
10_1101-2020_09_09_289074	238	26	-34.94	-34.94	FW
10_1101-2020_09_09_289074	238	27	-11.81	-11.81	:
10_1101-2020_09_09_289074	238	28	Q2	q2	NN
10_1101-2020_09_09_289074	238	29	GLY	GLY	NNP
10_1101-2020_09_09_289074	238	30	446	446	CD
10_1101-2020_09_09_289074	238	31	-22.52	-22.52	:
10_1101-2020_09_09_289074	238	32	-5.75	-5.75	CD
10_1101-2020_09_09_289074	238	33	0.00	0.00	CD
10_1101-2020_09_09_289074	238	34	-10.32	-10.32	HYPH
10_1101-2020_09_09_289074	238	35	-9.65	-9.65	CD
10_1101-2020_09_09_289074	238	36	Q3	Q3	NNP
10_1101-2020_09_09_289074	238	37	GLY	GLY	NNP
10_1101-2020_09_09_289074	238	38	447	447	CD
10_1101-2020_09_09_289074	238	39	-5.63	-5.63	CD
10_1101-2020_09_09_289074	238	40	0.00	0.00	CD
10_1101-2020_09_09_289074	238	41	0.00	0.00	CD
10_1101-2020_09_09_289074	238	42	0.00	0.00	CD
10_1101-2020_09_09_289074	238	43	-1.41	-1.41	CD
10_1101-2020_09_09_289074	238	44	Q3	q3	NN
10_1101-2020_09_09_289074	238	45	TYR	TYR	NNP
10_1101-2020_09_09_289074	238	46	449	449	CD
10_1101-2020_09_09_289074	238	47	-25.72	-25.72	-RRB-
10_1101-2020_09_09_289074	238	48	-6.38	-6.38	HYPH
10_1101-2020_09_09_289074	238	49	-20.37	-20.37	FW
10_1101-2020_09_09_289074	238	50	-24.76	-24.76	:
10_1101-2020_09_09_289074	238	51	-19.31	-19.31	-RRB-
10_1101-2020_09_09_289074	238	52	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	53	TYR	TYR	NNP
10_1101-2020_09_09_289074	238	54	453	453	CD
10_1101-2020_09_09_289074	238	55	0.00	0.00	CD
10_1101-2020_09_09_289074	238	56	0.00	0.00	CD
10_1101-2020_09_09_289074	238	57	-1.77	-1.77	CD
10_1101-2020_09_09_289074	238	58	-1.76	-1.76	CD
10_1101-2020_09_09_289074	238	59	-0.88	-0.88	CD
10_1101-2020_09_09_289074	238	60	Q4	Q4	NNP
10_1101-2020_09_09_289074	238	61	LEU	LEU	NNP
10_1101-2020_09_09_289074	238	62	455	455	CD
10_1101-2020_09_09_289074	238	63	-11.59	-11.59	HYPH
10_1101-2020_09_09_289074	238	64	-16.82	-16.82	NFP
10_1101-2020_09_09_289074	238	65	-21.78	-21.78	NFP
10_1101-2020_09_09_289074	238	66	-7.04	-7.04	HYPH
10_1101-2020_09_09_289074	238	67	-14.31	-14.31	NN
10_1101-2020_09_09_289074	238	68	Q2	q2	NN
10_1101-2020_09_09_289074	238	69	PHE	PHE	NNP
10_1101-2020_09_09_289074	238	70	456	456	CD
10_1101-2020_09_09_289074	238	71	-34.20	-34.20	JJ
10_1101-2020_09_09_289074	238	72	-30.16	-30.16	:
10_1101-2020_09_09_289074	238	73	-39.72	-39.72	NFP
10_1101-2020_09_09_289074	238	74	-20.76	-20.76	:
10_1101-2020_09_09_289074	238	75	-31.21	-31.21	:
10_1101-2020_09_09_289074	238	76	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	77	ALA	ALA	NNP
10_1101-2020_09_09_289074	238	78	475	475	CD
10_1101-2020_09_09_289074	238	79	-52.35	-52.35	:
10_1101-2020_09_09_289074	238	80	-49.72	-49.72	HYPH
10_1101-2020_09_09_289074	238	81	-38.73	-38.73	NFP
10_1101-2020_09_09_289074	238	82	-77.00	-77.00	NFP
10_1101-2020_09_09_289074	238	83	-54.45	-54.45	:
10_1101-2020_09_09_289074	238	84	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	85	GLY	GLY	NNP
10_1101-2020_09_09_289074	238	86	476	476	CD
10_1101-2020_09_09_289074	238	87	-21.72	-21.72	CD
10_1101-2020_09_09_289074	238	88	0.00	0.00	CD
10_1101-2020_09_09_289074	238	89	-17.16	-17.16	HYPH
10_1101-2020_09_09_289074	238	90	-34.59	-34.59	FW
10_1101-2020_09_09_289074	238	91	-18.37	-18.37	.
10_1101-2020_09_09_289074	238	92	Q2	Q2	NNP
10_1101-2020_09_09_289074	238	93	SER	SER	NNP
10_1101-2020_09_09_289074	238	94	477	477	CD
10_1101-2020_09_09_289074	238	95	-22.32	-22.32	.
10_1101-2020_09_09_289074	238	96	0.00	0.00	CD
10_1101-2020_09_09_289074	238	97	-11.44	-11.44	HYPH
10_1101-2020_09_09_289074	238	98	-40.68	-40.68	FW
10_1101-2020_09_09_289074	238	99	-18.61	-18.61	.
10_1101-2020_09_09_289074	238	100	Q2	q2	NN
10_1101-2020_09_09_289074	238	101	GLU	GLU	NNP
10_1101-2020_09_09_289074	238	102	484	484	CD
10_1101-2020_09_09_289074	238	103	-8.52	-8.52	CD
10_1101-2020_09_09_289074	238	104	-13.23	-13.23	CD
10_1101-2020_09_09_289074	238	105	0.00	0.00	CD
10_1101-2020_09_09_289074	238	106	0.00	0.00	CD
10_1101-2020_09_09_289074	238	107	-5.44	-5.44	CD
10_1101-2020_09_09_289074	238	108	Q3	q3	NN
10_1101-2020_09_09_289074	238	109	PHE	PHE	NNP
10_1101-2020_09_09_289074	238	110	486	486	CD
10_1101-2020_09_09_289074	238	111	-28.99	-28.99	:
10_1101-2020_09_09_289074	238	112	-53.63	-53.63	ADD
10_1101-2020_09_09_289074	238	113	-32.56	-32.56	FW
10_1101-2020_09_09_289074	238	114	-53.43	-53.43	FW
10_1101-2020_09_09_289074	238	115	-42.15	-42.15	:
10_1101-2020_09_09_289074	238	116	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	117	ASN	ASN	NNP
10_1101-2020_09_09_289074	238	118	487	487	CD
10_1101-2020_09_09_289074	238	119	-31.67	-31.67	CD
10_1101-2020_09_09_289074	238	120	-59.57	-59.57	NN
10_1101-2020_09_09_289074	238	121	-33.98	-33.98	ADD
10_1101-2020_09_09_289074	238	122	-52.21	-52.21	:
10_1101-2020_09_09_289074	238	123	-44.36	-44.36	:
10_1101-2020_09_09_289074	238	124	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	125	TYR	TYR	NNP
10_1101-2020_09_09_289074	238	126	489	489	CD
10_1101-2020_09_09_289074	238	127	-62.10	-62.10	:
10_1101-2020_09_09_289074	238	128	-27.67	-27.67	:
10_1101-2020_09_09_289074	238	129	-45.92	-45.92	ADD
10_1101-2020_09_09_289074	238	130	-69.38	-69.38	NFP
10_1101-2020_09_09_289074	238	131	-51.27	-51.27	:
10_1101-2020_09_09_289074	238	132	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	133	PHE	PHE	NNP
10_1101-2020_09_09_289074	238	134	490	490	CD
10_1101-2020_09_09_289074	238	135	-4.58	-4.58	CD
10_1101-2020_09_09_289074	238	136	-4.48	-4.48	CD
10_1101-2020_09_09_289074	238	137	-22.90	-22.90	HYPH
10_1101-2020_09_09_289074	238	138	-40.32	-40.32	FW
10_1101-2020_09_09_289074	238	139	-18.07	-18.07	NFP
10_1101-2020_09_09_289074	238	140	Q2	q2	NN
10_1101-2020_09_09_289074	238	141	GLN	GLN	NNP
10_1101-2020_09_09_289074	238	142	493	493	CD
10_1101-2020_09_09_289074	238	143	-37.20	-37.20	CD
10_1101-2020_09_09_289074	238	144	-56.08	-56.08	:
10_1101-2020_09_09_289074	238	145	-79.60	-79.60	-LRB-
10_1101-2020_09_09_289074	238	146	-70.51	-70.51	:
10_1101-2020_09_09_289074	238	147	-60.85	-60.85	:
10_1101-2020_09_09_289074	238	148	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	149	GLY	GLY	NNP
10_1101-2020_09_09_289074	238	150	496	496	CD
10_1101-2020_09_09_289074	238	151	-15.54	-15.54	CD
10_1101-2020_09_09_289074	238	152	-8.74	-8.74	CD
10_1101-2020_09_09_289074	238	153	-18.72	-18.72	HYPH
10_1101-2020_09_09_289074	238	154	-16.80	-16.80	:
10_1101-2020_09_09_289074	238	155	-14.95	-14.95	:
10_1101-2020_09_09_289074	238	156	Q2	q2	NN
10_1101-2020_09_09_289074	238	157	PHE	PHE	NNP
10_1101-2020_09_09_289074	238	158	497	497	CD
10_1101-2020_09_09_289074	238	159	-8.86	-8.86	CD
10_1101-2020_09_09_289074	238	160	0.00	0.00	CD
10_1101-2020_09_09_289074	238	161	-4.68	-4.68	CD
10_1101-2020_09_09_289074	238	162	-29.10	-29.10	NFP
10_1101-2020_09_09_289074	238	163	-10.66	-10.66	.
10_1101-2020_09_09_289074	238	164	Q3	q3	NN
10_1101-2020_09_09_289074	238	165	GLN	GLN	NNP
10_1101-2020_09_09_289074	238	166	498	498	CD
10_1101-2020_09_09_289074	238	167	-77.24	-77.24	-RRB-
10_1101-2020_09_09_289074	238	168	-80.38	-80.38	:
10_1101-2020_09_09_289074	238	169	-42.34	-42.34	CD
10_1101-2020_09_09_289074	238	170	0.00	0.00	CD
10_1101-2020_09_09_289074	238	171	-49.99	-49.99	:
10_1101-2020_09_09_289074	238	172	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	173	PRO	pro	RB
10_1101-2020_09_09_289074	238	174	499	499	CD
10_1101-2020_09_09_289074	238	175	0.00	0.00	CD
10_1101-2020_09_09_289074	238	176	0.00	0.00	CD
10_1101-2020_09_09_289074	238	177	0.00	0.00	CD
10_1101-2020_09_09_289074	238	178	-11.64	-11.64	-LRB-
10_1101-2020_09_09_289074	238	179	-2.91	-2.91	NFP
10_1101-2020_09_09_289074	238	180	Q3	Q3	VBD
10_1101-2020_09_09_289074	238	181	THR	THR	NNP
10_1101-2020_09_09_289074	238	182	500	500	CD
10_1101-2020_09_09_289074	238	183	0.00	0.00	CD
10_1101-2020_09_09_289074	238	184	-66.00	-66.00	:
10_1101-2020_09_09_289074	238	185	-92.90	-92.90	-LRB-
10_1101-2020_09_09_289074	238	186	-122.50	-122.50	NNP
10_1101-2020_09_09_289074	238	187	-70.35	-70.35	HYPH
10_1101-2020_09_09_289074	238	188	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	189	ASN	asn	NN
10_1101-2020_09_09_289074	238	190	501	501	CD
10_1101-2020_09_09_289074	238	191	-60.14	-60.14	NFP
10_1101-2020_09_09_289074	238	192	-61.04	-61.04	:
10_1101-2020_09_09_289074	238	193	-61.82	-61.82	FW
10_1101-2020_09_09_289074	238	194	-70.59	-70.59	FW
10_1101-2020_09_09_289074	238	195	-63.40	-63.40	.
10_1101-2020_09_09_289074	238	196	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	197	GLY	GLY	NNP
10_1101-2020_09_09_289074	238	198	502	502	CD
10_1101-2020_09_09_289074	238	199	-24.84	-24.84	HYPH
10_1101-2020_09_09_289074	238	200	-35.42	-35.42	:
10_1101-2020_09_09_289074	238	201	-39.45	-39.45	:
10_1101-2020_09_09_289074	238	202	-40.92	-40.92	FW
10_1101-2020_09_09_289074	238	203	-35.16	-35.16	FW
10_1101-2020_09_09_289074	238	204	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	205	VAL	VAL	NNP
10_1101-2020_09_09_289074	238	206	503	503	CD
10_1101-2020_09_09_289074	238	207	0.00	0.00	CD
10_1101-2020_09_09_289074	238	208	-5.37	-5.37	CD
10_1101-2020_09_09_289074	238	209	-5.45	-5.45	CD
10_1101-2020_09_09_289074	238	210	-5.54	-5.54	CD
10_1101-2020_09_09_289074	238	211	-4.09	-4.09	HYPH
10_1101-2020_09_09_289074	238	212	Q3	Q3	NNP
10_1101-2020_09_09_289074	238	213	TYR	TYR	NNP
10_1101-2020_09_09_289074	238	214	505	505	CD
10_1101-2020_09_09_289074	238	215	-30.60	-30.60	NN
10_1101-2020_09_09_289074	238	216	-23.22	-23.22	FW
10_1101-2020_09_09_289074	238	217	-20.90	-20.90	FW
10_1101-2020_09_09_289074	238	218	-40.62	-40.62	FW
10_1101-2020_09_09_289074	238	219	-28.84	-28.84	.
10_1101-2020_09_09_289074	238	220	Q1	Q1	NNP
10_1101-2020_09_09_289074	238	221	.CC	.CC	:
10_1101-2020_09_09_289074	238	222	-	-	:
10_1101-2020_09_09_289074	238	223	BY	by	IN
10_1101-2020_09_09_289074	238	224	-	-	HYPH
10_1101-2020_09_09_289074	238	225	NC	NC	NNP
10_1101-2020_09_09_289074	238	226	-	-	HYPH
10_1101-2020_09_09_289074	238	227	ND	ND	NNP
10_1101-2020_09_09_289074	238	228	4.0	4.0	CD
10_1101-2020_09_09_289074	238	229	International	International	NNP
10_1101-2020_09_09_289074	238	230	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	238	231	under	under	IN
10_1101-2020_09_09_289074	238	232	a	a	DT
10_1101-2020_09_09_289074	238	233	(	(	-LRB-
10_1101-2020_09_09_289074	238	234	which	which	WDT
10_1101-2020_09_09_289074	238	235	was	be	VBD
10_1101-2020_09_09_289074	238	236	not	not	RB
10_1101-2020_09_09_289074	238	237	certified	certify	VBN
10_1101-2020_09_09_289074	238	238	by	by	IN
10_1101-2020_09_09_289074	238	239	peer	peer	NN
10_1101-2020_09_09_289074	238	240	review	review	NN
10_1101-2020_09_09_289074	238	241	)	)	-RRB-
10_1101-2020_09_09_289074	238	242	is	be	VBZ
10_1101-2020_09_09_289074	238	243	the	the	DT
10_1101-2020_09_09_289074	238	244	author	author	NN
10_1101-2020_09_09_289074	238	245	/	/	SYM
10_1101-2020_09_09_289074	238	246	funder	funder	NN
10_1101-2020_09_09_289074	238	247	,	,	,
10_1101-2020_09_09_289074	238	248	who	who	WP
10_1101-2020_09_09_289074	238	249	has	have	VBZ
10_1101-2020_09_09_289074	238	250	granted	grant	VBN
10_1101-2020_09_09_289074	238	251	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	238	252	a	a	DT
10_1101-2020_09_09_289074	238	253	license	license	NN
10_1101-2020_09_09_289074	238	254	to	to	TO
10_1101-2020_09_09_289074	238	255	display	display	VB
10_1101-2020_09_09_289074	238	256	the	the	DT
10_1101-2020_09_09_289074	238	257	preprint	preprint	NN
10_1101-2020_09_09_289074	238	258	in	in	IN
10_1101-2020_09_09_289074	238	259	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	238	260	.	.	.
10_1101-2020_09_09_289074	239	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	239	2	is	be	VBZ
10_1101-2020_09_09_289074	239	3	made	make	VBN
10_1101-2020_09_09_289074	239	4	The	the	DT
10_1101-2020_09_09_289074	239	5	copyright	copyright	NN
10_1101-2020_09_09_289074	239	6	holder	holder	NN
10_1101-2020_09_09_289074	239	7	for	for	IN
10_1101-2020_09_09_289074	239	8	this	this	DT
10_1101-2020_09_09_289074	239	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	239	10	version	version	NN
10_1101-2020_09_09_289074	239	11	posted	post	VBD
10_1101-2020_09_09_289074	239	12	January	January	NNP
10_1101-2020_09_09_289074	239	13	5	5	CD
10_1101-2020_09_09_289074	239	14	,	,	,
10_1101-2020_09_09_289074	239	15	2021	2021	CD
10_1101-2020_09_09_289074	239	16	.	.	.
10_1101-2020_09_09_289074	239	17	;	;	:
10_1101-2020_09_09_289074	239	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	239	19	:	:	:
10_1101-2020_09_09_289074	239	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	239	21	preprint	preprint	NN
10_1101-2020_09_09_289074	239	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	239	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	239	24	19	19	CD
10_1101-2020_09_09_289074	239	25	Table	table	NN
10_1101-2020_09_09_289074	239	26	2	2	CD
10_1101-2020_09_09_289074	239	27	.	.	.
10_1101-2020_09_09_289074	240	1	GBPM	gbpm	NN
10_1101-2020_09_09_289074	240	2	scores	score	NNS
10_1101-2020_09_09_289074	240	3	,	,	,
10_1101-2020_09_09_289074	240	4	average	average	JJ
10_1101-2020_09_09_289074	240	5	values	value	NNS
10_1101-2020_09_09_289074	240	6	,	,	,
10_1101-2020_09_09_289074	240	7	and	and	CC
10_1101-2020_09_09_289074	240	8	quartile	quartile	JJ
10_1101-2020_09_09_289074	240	9	distribution	distribution	NN
10_1101-2020_09_09_289074	240	10	of	of	IN
10_1101-2020_09_09_289074	240	11	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	240	12	relevant	relevant	JJ
10_1101-2020_09_09_289074	240	13	AAs	AAs	NNP
10_1101-2020_09_09_289074	240	14	in	in	IN
10_1101-2020_09_09_289074	240	15	three	three	CD
10_1101-2020_09_09_289074	240	16	PDB	PDB	NNP
10_1101-2020_09_09_289074	240	17	models	model	NNS
10_1101-2020_09_09_289074	240	18	.	.	.
10_1101-2020_09_09_289074	241	1	GBPM	gbpm	NN
10_1101-2020_09_09_289074	241	2	scores	score	NNS
10_1101-2020_09_09_289074	241	3	and	and	CC
10_1101-2020_09_09_289074	241	4	average	average	JJ
10_1101-2020_09_09_289074	241	5	values	value	NNS
10_1101-2020_09_09_289074	241	6	are	be	VBP
10_1101-2020_09_09_289074	241	7	reported	report	VBN
10_1101-2020_09_09_289074	241	8	in	in	IN
10_1101-2020_09_09_289074	241	9	kcal	kcal	NNP
10_1101-2020_09_09_289074	241	10	/	/	SYM
10_1101-2020_09_09_289074	241	11	mol	mol	NN
10_1101-2020_09_09_289074	241	12	.	.	.
10_1101-2020_09_09_289074	242	1	Residue	Residue	NNP
10_1101-2020_09_09_289074	242	2	#	#	NN
10_1101-2020_09_09_289074	242	3	PDB	PDB	NNP
10_1101-2020_09_09_289074	242	4	entries	entrie	VBZ
10_1101-2020_09_09_289074	242	5	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	242	6	6LZG	6lzg	NN
10_1101-2020_09_09_289074	242	7	6M0J	6m0j	CD
10_1101-2020_09_09_289074	242	8	6VW1-A	6vw1-a	CD
10_1101-2020_09_09_289074	242	9	6VW1-B	6vw1-b	CD
10_1101-2020_09_09_289074	242	10	Average	average	JJ
10_1101-2020_09_09_289074	242	11	Score	score	NN
10_1101-2020_09_09_289074	242	12	Quartile	Quartile	NNP
10_1101-2020_09_09_289074	242	13	SER	SER	NNP
10_1101-2020_09_09_289074	242	14	19	19	CD
10_1101-2020_09_09_289074	242	15	-31.45	-31.45	HYPH
10_1101-2020_09_09_289074	242	16	-26.08	-26.08	:
10_1101-2020_09_09_289074	242	17	-53.61	-53.61	NFP
10_1101-2020_09_09_289074	242	18	-79.33	-79.33	FW
10_1101-2020_09_09_289074	242	19	-47.62	-47.62	NNP
10_1101-2020_09_09_289074	242	20	Q1	Q1	NNP
10_1101-2020_09_09_289074	242	21	GLN	GLN	NNP
10_1101-2020_09_09_289074	242	22	24	24	CD
10_1101-2020_09_09_289074	242	23	-31.15	-31.15	HYPH
10_1101-2020_09_09_289074	242	24	-23.62	-23.62	:
10_1101-2020_09_09_289074	242	25	-34.15	-34.15	:
10_1101-2020_09_09_289074	242	26	-85.23	-85.23	FW
10_1101-2020_09_09_289074	242	27	-43.54	-43.54	.
10_1101-2020_09_09_289074	242	28	Q1	Q1	NNP
10_1101-2020_09_09_289074	242	29	THR	THR	NNP
10_1101-2020_09_09_289074	242	30	27	27	CD
10_1101-2020_09_09_289074	242	31	-16.93	-16.93	:
10_1101-2020_09_09_289074	242	32	-32.58	-32.58	NFP
10_1101-2020_09_09_289074	242	33	-38.70	-38.70	NFP
10_1101-2020_09_09_289074	242	34	-16.65	-16.65	-LRB-
10_1101-2020_09_09_289074	242	35	-26.22	-26.22	.
10_1101-2020_09_09_289074	242	36	Q2	q2	NN
10_1101-2020_09_09_289074	242	37	PHE	PHE	NNP
10_1101-2020_09_09_289074	242	38	28	28	CD
10_1101-2020_09_09_289074	242	39	-20.68	-20.68	:
10_1101-2020_09_09_289074	242	40	-25.02	-25.02	HYPH
10_1101-2020_09_09_289074	242	41	-14.10	-14.10	.
10_1101-2020_09_09_289074	242	42	-27.48	-27.48	:
10_1101-2020_09_09_289074	242	43	-21.82	-21.82	.
10_1101-2020_09_09_289074	242	44	Q2	Q2	NNP
10_1101-2020_09_09_289074	242	45	ASP	ASP	NNP
10_1101-2020_09_09_289074	242	46	30	30	CD
10_1101-2020_09_09_289074	242	47	0.00	0.00	CD
10_1101-2020_09_09_289074	242	48	-17.01	-17.01	SYM
10_1101-2020_09_09_289074	242	49	0.00	0.00	CD
10_1101-2020_09_09_289074	242	50	0.00	0.00	CD
10_1101-2020_09_09_289074	242	51	-4.25	-4.25	CD
10_1101-2020_09_09_289074	242	52	Q3	Q3	NNP
10_1101-2020_09_09_289074	242	53	LYS	LYS	NNP
10_1101-2020_09_09_289074	242	54	31	31	CD
10_1101-2020_09_09_289074	242	55	-84.06	-84.06	:
10_1101-2020_09_09_289074	242	56	-43.67	-43.67	:
10_1101-2020_09_09_289074	242	57	-32.98	-32.98	:
10_1101-2020_09_09_289074	242	58	-46.60	-46.60	FW
10_1101-2020_09_09_289074	242	59	-51.83	-51.83	:
10_1101-2020_09_09_289074	242	60	Q1	Q1	NNP
10_1101-2020_09_09_289074	242	61	HIS	his	PRP$
10_1101-2020_09_09_289074	242	62	34	34	CD
10_1101-2020_09_09_289074	242	63	0.00	0.00	CD
10_1101-2020_09_09_289074	242	64	-30.42	-30.42	:
10_1101-2020_09_09_289074	242	65	-27.78	-27.78	FW
10_1101-2020_09_09_289074	242	66	-67.56	-67.56	FW
10_1101-2020_09_09_289074	242	67	-31.44	-31.44	.
10_1101-2020_09_09_289074	242	68	Q2	Q2	NNP
10_1101-2020_09_09_289074	242	69	GLU	GLU	NNP
10_1101-2020_09_09_289074	242	70	35	35	CD
10_1101-2020_09_09_289074	242	71	-11.73	-11.73	CD
10_1101-2020_09_09_289074	242	72	0.00	0.00	CD
10_1101-2020_09_09_289074	242	73	0.00	0.00	CD
10_1101-2020_09_09_289074	242	74	-19.40	-19.40	NFP
10_1101-2020_09_09_289074	242	75	-7.78	-7.78	NN
10_1101-2020_09_09_289074	242	76	Q2	q2	NN
10_1101-2020_09_09_289074	242	77	GLU	GLU	NNP
10_1101-2020_09_09_289074	242	78	37	37	CD
10_1101-2020_09_09_289074	242	79	-11.58	-11.58	:
10_1101-2020_09_09_289074	242	80	-20.36	-20.36	FW
10_1101-2020_09_09_289074	242	81	-11.83	-11.83	FW
10_1101-2020_09_09_289074	242	82	-20.52	-20.52	XX
10_1101-2020_09_09_289074	242	83	-16.07	-16.07	.
10_1101-2020_09_09_289074	242	84	Q2	Q2	NNP
10_1101-2020_09_09_289074	242	85	ASP	ASP	NNP
10_1101-2020_09_09_289074	242	86	38	38	CD
10_1101-2020_09_09_289074	242	87	-41.09	-41.09	HYPH
10_1101-2020_09_09_289074	242	88	-40.52	-40.52	FW
10_1101-2020_09_09_289074	242	89	-25.75	-25.75	FW
10_1101-2020_09_09_289074	242	90	-34.16	-34.16	:
10_1101-2020_09_09_289074	242	91	-35.38	-35.38	NFP
10_1101-2020_09_09_289074	242	92	Q2	q2	NN
10_1101-2020_09_09_289074	242	93	TYR	TYR	NNP
10_1101-2020_09_09_289074	242	94	41	41	CD
10_1101-2020_09_09_289074	242	95	-52.50	-52.50	-LRB-
10_1101-2020_09_09_289074	242	96	-75.07	-75.07	:
10_1101-2020_09_09_289074	242	97	-62.35	-62.35	FW
10_1101-2020_09_09_289074	242	98	-76.07	-76.07	FW
10_1101-2020_09_09_289074	242	99	-66.50	-66.50	:
10_1101-2020_09_09_289074	242	100	Q1	Q1	NNP
10_1101-2020_09_09_289074	242	101	GLN	GLN	NNP
10_1101-2020_09_09_289074	242	102	42	42	CD
10_1101-2020_09_09_289074	242	103	-36.78	-36.78	HYPH
10_1101-2020_09_09_289074	242	104	-37.15	-37.15	NN
10_1101-2020_09_09_289074	242	105	-28.53	-28.53	FW
10_1101-2020_09_09_289074	242	106	-63.49	-63.49	:
10_1101-2020_09_09_289074	242	107	-41.49	-41.49	:
10_1101-2020_09_09_289074	242	108	Q2	Q2	NNP
10_1101-2020_09_09_289074	242	109	LEU	LEU	NNP
10_1101-2020_09_09_289074	242	110	45	45	CD
10_1101-2020_09_09_289074	242	111	-12.80	-12.80	HYPH
10_1101-2020_09_09_289074	242	112	-16.43	-16.43	:
10_1101-2020_09_09_289074	242	113	0.00	0.00	CD
10_1101-2020_09_09_289074	242	114	-16.20	-16.20	NFP
10_1101-2020_09_09_289074	242	115	-11.36	-11.36	:
10_1101-2020_09_09_289074	242	116	Q2	Q2	NNP
10_1101-2020_09_09_289074	242	117	LEU	LEU	NNP
10_1101-2020_09_09_289074	242	118	79	79	CD
10_1101-2020_09_09_289074	242	119	0.00	0.00	CD
10_1101-2020_09_09_289074	242	120	0.00	0.00	CD
10_1101-2020_09_09_289074	242	121	0.00	0.00	CD
10_1101-2020_09_09_289074	242	122	-5.99	-5.99	CD
10_1101-2020_09_09_289074	242	123	-1.50	-1.50	CD
10_1101-2020_09_09_289074	242	124	Q3	q3	NN
10_1101-2020_09_09_289074	242	125	MET	MET	NNP
10_1101-2020_09_09_289074	242	126	82	82	CD
10_1101-2020_09_09_289074	242	127	0.00	0.00	CD
10_1101-2020_09_09_289074	242	128	0.00	0.00	CD
10_1101-2020_09_09_289074	242	129	-6.36	-6.36	CD
10_1101-2020_09_09_289074	242	130	-6.00	-6.00	CD
10_1101-2020_09_09_289074	242	131	-3.09	-3.09	NFP
10_1101-2020_09_09_289074	242	132	Q3	Q3	NNP
10_1101-2020_09_09_289074	242	133	TYR	TYR	NNP
10_1101-2020_09_09_289074	242	134	83	83	CD
10_1101-2020_09_09_289074	242	135	-40.50	-40.50	CD
10_1101-2020_09_09_289074	242	136	-66.29	-66.29	HYPH
10_1101-2020_09_09_289074	242	137	-57.86	-57.86	FW
10_1101-2020_09_09_289074	242	138	-60.81	-60.81	NFP
10_1101-2020_09_09_289074	242	139	-56.37	-56.37	WP
10_1101-2020_09_09_289074	242	140	Q1	Q1	NNP
10_1101-2020_09_09_289074	242	141	GLU	GLU	NNP
10_1101-2020_09_09_289074	242	142	329	329	CD
10_1101-2020_09_09_289074	242	143	0.00	0.00	CD
10_1101-2020_09_09_289074	242	144	0.00	0.00	CD
10_1101-2020_09_09_289074	242	145	0.00	0.00	CD
10_1101-2020_09_09_289074	242	146	-17.25	-17.25	HYPH
10_1101-2020_09_09_289074	242	147	-4.31	-4.31	NN
10_1101-2020_09_09_289074	242	148	Q3	Q3	NNP
10_1101-2020_09_09_289074	242	149	ASN	ASN	NNP
10_1101-2020_09_09_289074	242	150	330	330	CD
10_1101-2020_09_09_289074	242	151	-11.84	-11.84	HYPH
10_1101-2020_09_09_289074	242	152	-5.92	-5.92	CD
10_1101-2020_09_09_289074	242	153	-11.82	-11.82	:
10_1101-2020_09_09_289074	242	154	-6.04	-6.04	CD
10_1101-2020_09_09_289074	242	155	-8.91	-8.91	CD
10_1101-2020_09_09_289074	242	156	Q2	q2	NN
10_1101-2020_09_09_289074	242	157	GLY	GLY	NNP
10_1101-2020_09_09_289074	242	158	352	352	CD
10_1101-2020_09_09_289074	242	159	-1.97	-1.97	CD
10_1101-2020_09_09_289074	242	160	-8.36	-8.36	CD
10_1101-2020_09_09_289074	242	161	-8.86	-8.86	CD
10_1101-2020_09_09_289074	242	162	-14.66	-14.66	-RRB-
10_1101-2020_09_09_289074	242	163	-8.46	-8.46	CD
10_1101-2020_09_09_289074	242	164	Q2	q2	NN
10_1101-2020_09_09_289074	242	165	LYS	LYS	NNP
10_1101-2020_09_09_289074	242	166	353	353	CD
10_1101-2020_09_09_289074	242	167	-79.38	-79.38	:
10_1101-2020_09_09_289074	242	168	-70.11	-70.11	:
10_1101-2020_09_09_289074	242	169	-120.73	-120.73	NNP
10_1101-2020_09_09_289074	242	170	-46.03	-46.03	:
10_1101-2020_09_09_289074	242	171	-79.06	-79.06	NNP
10_1101-2020_09_09_289074	242	172	Q1	Q1	NNP
10_1101-2020_09_09_289074	242	173	GLY	GLY	NNP
10_1101-2020_09_09_289074	242	174	354	354	CD
10_1101-2020_09_09_289074	242	175	-21.87	-21.87	:
10_1101-2020_09_09_289074	242	176	-31.15	-31.15	:
10_1101-2020_09_09_289074	242	177	-12.74	-12.74	:
10_1101-2020_09_09_289074	242	178	-15.25	-15.25	:
10_1101-2020_09_09_289074	242	179	-20.25	-20.25	:
10_1101-2020_09_09_289074	242	180	Q2	Q2	NNP
10_1101-2020_09_09_289074	242	181	ASP	ASP	NNP
10_1101-2020_09_09_289074	242	182	355	355	CD
10_1101-2020_09_09_289074	242	183	-68.95	-68.95	HYPH
10_1101-2020_09_09_289074	242	184	-81.24	-81.24	FW
10_1101-2020_09_09_289074	242	185	-57.99	-57.99	FW
10_1101-2020_09_09_289074	242	186	-89.12	-89.12	NFP
10_1101-2020_09_09_289074	242	187	-74.33	-74.33	:
10_1101-2020_09_09_289074	242	188	Q1	Q1	NNP
10_1101-2020_09_09_289074	242	189	ARG	ARG	NNP
10_1101-2020_09_09_289074	242	190	357	357	CD
10_1101-2020_09_09_289074	242	191	0.00	0.00	CD
10_1101-2020_09_09_289074	242	192	-4.99	-4.99	CD
10_1101-2020_09_09_289074	242	193	0.00	0.00	CD
10_1101-2020_09_09_289074	242	194	0.00	0.00	CD
10_1101-2020_09_09_289074	242	195	-1.25	-1.25	CD
10_1101-2020_09_09_289074	242	196	Q3	q3	NN
10_1101-2020_09_09_289074	242	197	ALA	ALA	NNP
10_1101-2020_09_09_289074	242	198	386	386	CD
10_1101-2020_09_09_289074	242	199	0.00	0.00	CD
10_1101-2020_09_09_289074	242	200	0.00	0.00	CD
10_1101-2020_09_09_289074	242	201	-4.85	-4.85	CD
10_1101-2020_09_09_289074	242	202	0.00	0.00	CD
10_1101-2020_09_09_289074	242	203	-1.21	-1.21	CD
10_1101-2020_09_09_289074	242	204	Q4	q4	NN
10_1101-2020_09_09_289074	242	205	ARG	arg	NN
10_1101-2020_09_09_289074	242	206	393	393	CD
10_1101-2020_09_09_289074	242	207	0.00	0.00	CD
10_1101-2020_09_09_289074	242	208	0.00	0.00	CD
10_1101-2020_09_09_289074	242	209	-4.85	-4.85	CD
10_1101-2020_09_09_289074	242	210	0.00	0.00	CD
10_1101-2020_09_09_289074	242	211	-1.21	-1.21	CD
10_1101-2020_09_09_289074	242	212	Q4	q4	NN
10_1101-2020_09_09_289074	242	213	.CC	.CC	NFP
10_1101-2020_09_09_289074	242	214	-	-	:
10_1101-2020_09_09_289074	242	215	BY	by	IN
10_1101-2020_09_09_289074	242	216	-	-	HYPH
10_1101-2020_09_09_289074	242	217	NC	NC	NNP
10_1101-2020_09_09_289074	242	218	-	-	HYPH
10_1101-2020_09_09_289074	242	219	ND	ND	NNP
10_1101-2020_09_09_289074	242	220	4.0	4.0	CD
10_1101-2020_09_09_289074	242	221	International	International	NNP
10_1101-2020_09_09_289074	242	222	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	242	223	under	under	IN
10_1101-2020_09_09_289074	242	224	a	a	DT
10_1101-2020_09_09_289074	242	225	(	(	-LRB-
10_1101-2020_09_09_289074	242	226	which	which	WDT
10_1101-2020_09_09_289074	242	227	was	be	VBD
10_1101-2020_09_09_289074	242	228	not	not	RB
10_1101-2020_09_09_289074	242	229	certified	certify	VBN
10_1101-2020_09_09_289074	242	230	by	by	IN
10_1101-2020_09_09_289074	242	231	peer	peer	NN
10_1101-2020_09_09_289074	242	232	review	review	NN
10_1101-2020_09_09_289074	242	233	)	)	-RRB-
10_1101-2020_09_09_289074	242	234	is	be	VBZ
10_1101-2020_09_09_289074	242	235	the	the	DT
10_1101-2020_09_09_289074	242	236	author	author	NN
10_1101-2020_09_09_289074	242	237	/	/	SYM
10_1101-2020_09_09_289074	242	238	funder	funder	NN
10_1101-2020_09_09_289074	242	239	,	,	,
10_1101-2020_09_09_289074	242	240	who	who	WP
10_1101-2020_09_09_289074	242	241	has	have	VBZ
10_1101-2020_09_09_289074	242	242	granted	grant	VBN
10_1101-2020_09_09_289074	242	243	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	242	244	a	a	DT
10_1101-2020_09_09_289074	242	245	license	license	NN
10_1101-2020_09_09_289074	242	246	to	to	TO
10_1101-2020_09_09_289074	242	247	display	display	VB
10_1101-2020_09_09_289074	242	248	the	the	DT
10_1101-2020_09_09_289074	242	249	preprint	preprint	NN
10_1101-2020_09_09_289074	242	250	in	in	IN
10_1101-2020_09_09_289074	242	251	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	242	252	.	.	.
10_1101-2020_09_09_289074	243	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	243	2	is	be	VBZ
10_1101-2020_09_09_289074	243	3	made	make	VBN
10_1101-2020_09_09_289074	243	4	The	the	DT
10_1101-2020_09_09_289074	243	5	copyright	copyright	NN
10_1101-2020_09_09_289074	243	6	holder	holder	NN
10_1101-2020_09_09_289074	243	7	for	for	IN
10_1101-2020_09_09_289074	243	8	this	this	DT
10_1101-2020_09_09_289074	243	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	243	10	version	version	NN
10_1101-2020_09_09_289074	243	11	posted	post	VBD
10_1101-2020_09_09_289074	243	12	January	January	NNP
10_1101-2020_09_09_289074	243	13	5	5	CD
10_1101-2020_09_09_289074	243	14	,	,	,
10_1101-2020_09_09_289074	243	15	2021	2021	CD
10_1101-2020_09_09_289074	243	16	.	.	.
10_1101-2020_09_09_289074	243	17	;	;	:
10_1101-2020_09_09_289074	243	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	243	19	:	:	:
10_1101-2020_09_09_289074	243	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	243	21	preprint	preprint	NN
10_1101-2020_09_09_289074	243	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	243	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	243	24	20	20	CD
10_1101-2020_09_09_289074	243	25	Table	table	NN
10_1101-2020_09_09_289074	243	26	3	3	CD
10_1101-2020_09_09_289074	243	27	.	.	.
10_1101-2020_09_09_289074	244	1	Composition	composition	NN
10_1101-2020_09_09_289074	244	2	of	of	IN
10_1101-2020_09_09_289074	244	3	the	the	DT
10_1101-2020_09_09_289074	244	4	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	244	5	models	model	NNS
10_1101-2020_09_09_289074	244	6	designed	design	VBN
10_1101-2020_09_09_289074	244	7	.	.	.
10_1101-2020_09_09_289074	245	1	HBD	HBD	NNP
10_1101-2020_09_09_289074	245	2	=	=	SYM
10_1101-2020_09_09_289074	245	3	Hydrogen	Hydrogen	NNP
10_1101-2020_09_09_289074	245	4	Bond	Bond	NNP
10_1101-2020_09_09_289074	245	5	Donor	Donor	NNP
10_1101-2020_09_09_289074	245	6	;	;	:
10_1101-2020_09_09_289074	245	7	HBA	HBA	NNP
10_1101-2020_09_09_289074	245	8	=	=	SYM
10_1101-2020_09_09_289074	245	9	Hysdrogen	Hysdrogen	NNP
10_1101-2020_09_09_289074	245	10	Bond	Bond	NNP
10_1101-2020_09_09_289074	245	11	Acceptor	Acceptor	NNP
10_1101-2020_09_09_289074	245	12	;	;	:
10_1101-2020_09_09_289074	245	13	#	#	NN
10_1101-2020_09_09_289074	245	14	=	=	SYM
10_1101-2020_09_09_289074	245	15	number	number	NN
10_1101-2020_09_09_289074	245	16	of	of	IN
10_1101-2020_09_09_289074	245	17	features	feature	NNS
10_1101-2020_09_09_289074	245	18	;	;	:
10_1101-2020_09_09_289074	245	19	AIE	AIE	NNP
10_1101-2020_09_09_289074	245	20	=	=	NFP
10_1101-2020_09_09_289074	245	21	Average	Average	NNP
10_1101-2020_09_09_289074	245	22	Interaction	Interaction	NNP
10_1101-2020_09_09_289074	245	23	Energy	Energy	NNP
10_1101-2020_09_09_289074	245	24	(	(	-LRB-
10_1101-2020_09_09_289074	245	25	in	in	IN
10_1101-2020_09_09_289074	245	26	kcal	kcal	NNP
10_1101-2020_09_09_289074	245	27	/	/	SYM
10_1101-2020_09_09_289074	245	28	mol	mol	NN
10_1101-2020_09_09_289074	245	29	)	)	-RRB-
10_1101-2020_09_09_289074	245	30	.	.	.
10_1101-2020_09_09_289074	246	1	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	246	2	Feature	Feature	NNP
10_1101-2020_09_09_289074	246	3	6LZG	6lzg	NN
10_1101-2020_09_09_289074	246	4	6M0J	6m0j	CD
10_1101-2020_09_09_289074	246	5	6VW1-A	6vw1-a	NN
10_1101-2020_09_09_289074	246	6	6VW1-B	6vw1-b	CD
10_1101-2020_09_09_289074	246	7	Host	host	NN
10_1101-2020_09_09_289074	246	8	/	/	SYM
10_1101-2020_09_09_289074	246	9	Guest	Guest	NNP
10_1101-2020_09_09_289074	246	10	#	#	NN
10_1101-2020_09_09_289074	246	11	AIE	aie	NN
10_1101-2020_09_09_289074	246	12	#	#	NN
10_1101-2020_09_09_289074	246	13	AIE	aie	NN
10_1101-2020_09_09_289074	246	14	#	#	NN
10_1101-2020_09_09_289074	246	15	AIE	aie	NN
10_1101-2020_09_09_289074	246	16	#	#	NN
10_1101-2020_09_09_289074	246	17	AIE	aie	NN
10_1101-2020_09_09_289074	246	18	Hydrophobic	hydrophobic	NN
10_1101-2020_09_09_289074	246	19	4	4	CD
10_1101-2020_09_09_289074	246	20	-2.07	-2.07	CD
10_1101-2020_09_09_289074	246	21	4	4	CD
10_1101-2020_09_09_289074	246	22	-1.82	-1.82	CD
10_1101-2020_09_09_289074	246	23	5	5	CD
10_1101-2020_09_09_289074	246	24	-2.05	-2.05	CD
10_1101-2020_09_09_289074	246	25	3	3	CD
10_1101-2020_09_09_289074	246	26	-2.12	-2.12	CD
10_1101-2020_09_09_289074	246	27	Spike	Spike	NNP
10_1101-2020_09_09_289074	246	28	/	/	SYM
10_1101-2020_09_09_289074	246	29	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	246	30	HBD	HBD	NNP
10_1101-2020_09_09_289074	246	31	18	18	CD
10_1101-2020_09_09_289074	246	32	-6.48	-6.48	CD
10_1101-2020_09_09_289074	246	33	15	15	CD
10_1101-2020_09_09_289074	246	34	-6.47	-6.47	CD
10_1101-2020_09_09_289074	246	35	17	17	CD
10_1101-2020_09_09_289074	246	36	-6.22	-6.22	CD
10_1101-2020_09_09_289074	246	37	19	19	CD
10_1101-2020_09_09_289074	246	38	-6.31	-6.31	CD
10_1101-2020_09_09_289074	246	39	HBA	HBA	NNP
10_1101-2020_09_09_289074	246	40	4	4	CD
10_1101-2020_09_09_289074	246	41	-6.61	-6.61	CD
10_1101-2020_09_09_289074	246	42	13	13	CD
10_1101-2020_09_09_289074	246	43	-5.25	-5.25	CD
10_1101-2020_09_09_289074	246	44	12	12	CD
10_1101-2020_09_09_289074	246	45	-5.47	-5.47	CD
10_1101-2020_09_09_289074	246	46	14	14	CD
10_1101-2020_09_09_289074	246	47	-5.48	-5.48	CD
10_1101-2020_09_09_289074	246	48	Hydrophobic	hydrophobic	NN
10_1101-2020_09_09_289074	246	49	1	1	CD
10_1101-2020_09_09_289074	246	50	-1.49	-1.49	CD
10_1101-2020_09_09_289074	246	51	3	3	CD
10_1101-2020_09_09_289074	246	52	-1.16	-1.16	CD
10_1101-2020_09_09_289074	246	53	2	2	CD
10_1101-2020_09_09_289074	246	54	-1.49	-1.49	CD
10_1101-2020_09_09_289074	246	55	1	1	CD
10_1101-2020_09_09_289074	246	56	-1.76	-1.76	CD
10_1101-2020_09_09_289074	246	57	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	246	58	/	/	SYM
10_1101-2020_09_09_289074	246	59	Spike	Spike	NNP
10_1101-2020_09_09_289074	246	60	HBD	HBD	NNP
10_1101-2020_09_09_289074	246	61	18	18	CD
10_1101-2020_09_09_289074	246	62	-6.26	-6.26	CD
10_1101-2020_09_09_289074	246	63	18	18	CD
10_1101-2020_09_09_289074	246	64	-6.32	-6.32	CD
10_1101-2020_09_09_289074	246	65	24	24	CD
10_1101-2020_09_09_289074	246	66	-5.63	-5.63	CD
10_1101-2020_09_09_289074	246	67	28	28	CD
10_1101-2020_09_09_289074	246	68	-5.94	-5.94	CD
10_1101-2020_09_09_289074	246	69	HBA	HBA	NNP
10_1101-2020_09_09_289074	246	70	7	7	CD
10_1101-2020_09_09_289074	246	71	-4.84	-4.84	CD
10_1101-2020_09_09_289074	246	72	10	10	CD
10_1101-2020_09_09_289074	246	73	-4.53	-4.53	CD
10_1101-2020_09_09_289074	246	74	9	9	CD
10_1101-2020_09_09_289074	246	75	-4.98	-4.98	CD
10_1101-2020_09_09_289074	246	76	12	12	CD
10_1101-2020_09_09_289074	246	77	-4.60	-4.60	CD
10_1101-2020_09_09_289074	246	78	.CC	.CC	:
10_1101-2020_09_09_289074	246	79	-	-	HYPH
10_1101-2020_09_09_289074	246	80	BY	by	IN
10_1101-2020_09_09_289074	246	81	-	-	HYPH
10_1101-2020_09_09_289074	246	82	NC	NC	NNP
10_1101-2020_09_09_289074	246	83	-	-	HYPH
10_1101-2020_09_09_289074	246	84	ND	ND	NNP
10_1101-2020_09_09_289074	246	85	4.0	4.0	CD
10_1101-2020_09_09_289074	246	86	International	International	NNP
10_1101-2020_09_09_289074	246	87	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	246	88	under	under	IN
10_1101-2020_09_09_289074	246	89	a	a	DT
10_1101-2020_09_09_289074	246	90	(	(	-LRB-
10_1101-2020_09_09_289074	246	91	which	which	WDT
10_1101-2020_09_09_289074	246	92	was	be	VBD
10_1101-2020_09_09_289074	246	93	not	not	RB
10_1101-2020_09_09_289074	246	94	certified	certify	VBN
10_1101-2020_09_09_289074	246	95	by	by	IN
10_1101-2020_09_09_289074	246	96	peer	peer	NN
10_1101-2020_09_09_289074	246	97	review	review	NN
10_1101-2020_09_09_289074	246	98	)	)	-RRB-
10_1101-2020_09_09_289074	246	99	is	be	VBZ
10_1101-2020_09_09_289074	246	100	the	the	DT
10_1101-2020_09_09_289074	246	101	author	author	NN
10_1101-2020_09_09_289074	246	102	/	/	SYM
10_1101-2020_09_09_289074	246	103	funder	funder	NN
10_1101-2020_09_09_289074	246	104	,	,	,
10_1101-2020_09_09_289074	246	105	who	who	WP
10_1101-2020_09_09_289074	246	106	has	have	VBZ
10_1101-2020_09_09_289074	246	107	granted	grant	VBN
10_1101-2020_09_09_289074	246	108	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	246	109	a	a	DT
10_1101-2020_09_09_289074	246	110	license	license	NN
10_1101-2020_09_09_289074	246	111	to	to	TO
10_1101-2020_09_09_289074	246	112	display	display	VB
10_1101-2020_09_09_289074	246	113	the	the	DT
10_1101-2020_09_09_289074	246	114	preprint	preprint	NN
10_1101-2020_09_09_289074	246	115	in	in	IN
10_1101-2020_09_09_289074	246	116	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	246	117	.	.	.
10_1101-2020_09_09_289074	247	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	247	2	is	be	VBZ
10_1101-2020_09_09_289074	247	3	made	make	VBN
10_1101-2020_09_09_289074	247	4	The	the	DT
10_1101-2020_09_09_289074	247	5	copyright	copyright	NN
10_1101-2020_09_09_289074	247	6	holder	holder	NN
10_1101-2020_09_09_289074	247	7	for	for	IN
10_1101-2020_09_09_289074	247	8	this	this	DT
10_1101-2020_09_09_289074	247	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	247	10	version	version	NN
10_1101-2020_09_09_289074	247	11	posted	post	VBD
10_1101-2020_09_09_289074	247	12	January	January	NNP
10_1101-2020_09_09_289074	247	13	5	5	CD
10_1101-2020_09_09_289074	247	14	,	,	,
10_1101-2020_09_09_289074	247	15	2021	2021	CD
10_1101-2020_09_09_289074	247	16	.	.	.
10_1101-2020_09_09_289074	247	17	;	;	:
10_1101-2020_09_09_289074	247	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	247	19	:	:	:
10_1101-2020_09_09_289074	247	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	247	21	preprint	preprint	NN
10_1101-2020_09_09_289074	247	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	247	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	NN
10_1101-2020_09_09_289074	247	24	21	21	CD
10_1101-2020_09_09_289074	247	25	Table	table	NN
10_1101-2020_09_09_289074	247	26	4	4	CD
10_1101-2020_09_09_289074	247	27	.	.	.
10_1101-2020_09_09_289074	248	1	Spike	spike	JJ
10_1101-2020_09_09_289074	248	2	mutations	mutation	NNS
10_1101-2020_09_09_289074	248	3	located	locate	VBN
10_1101-2020_09_09_289074	248	4	within	within	IN
10_1101-2020_09_09_289074	248	5	the	the	DT
10_1101-2020_09_09_289074	248	6	RBD	RBD	NNP
10_1101-2020_09_09_289074	248	7	(	(	-LRB-
10_1101-2020_09_09_289074	248	8	AA	AA	NNP
10_1101-2020_09_09_289074	248	9	330	330	CD
10_1101-2020_09_09_289074	248	10	-	-	SYM
10_1101-2020_09_09_289074	248	11	530	530	CD
10_1101-2020_09_09_289074	248	12	)	)	-RRB-
10_1101-2020_09_09_289074	248	13	with	with	IN
10_1101-2020_09_09_289074	248	14	at	at	RB
10_1101-2020_09_09_289074	248	15	least	least	RBS
10_1101-2020_09_09_289074	248	16	two	two	CD
10_1101-2020_09_09_289074	248	17	cases	case	NNS
10_1101-2020_09_09_289074	248	18	in	in	IN
10_1101-2020_09_09_289074	248	19	the	the	DT
10_1101-2020_09_09_289074	248	20	population	population	NN
10_1101-2020_09_09_289074	248	21	and	and	CC
10_1101-2020_09_09_289074	248	22	non	non	JJ
10_1101-2020_09_09_289074	248	23	-	-	JJ
10_1101-2020_09_09_289074	248	24	zero	zero	CD
10_1101-2020_09_09_289074	248	25	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	248	26	average	average	JJ
10_1101-2020_09_09_289074	248	27	score	score	NN
10_1101-2020_09_09_289074	248	28	in	in	IN
10_1101-2020_09_09_289074	248	29	the	the	DT
10_1101-2020_09_09_289074	248	30	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	248	31	/	/	SYM
10_1101-2020_09_09_289074	248	32	Spike	Spike	NNP
10_1101-2020_09_09_289074	248	33	interaction	interaction	NN
10_1101-2020_09_09_289074	248	34	models	model	NNS
10_1101-2020_09_09_289074	248	35	.	.	.
10_1101-2020_09_09_289074	249	1	The	the	DT
10_1101-2020_09_09_289074	249	2	asterisk	asterisk	NN
10_1101-2020_09_09_289074	249	3	(	(	-LRB-
10_1101-2020_09_09_289074	249	4	*	*	NFP
10_1101-2020_09_09_289074	249	5	)	)	-RRB-
10_1101-2020_09_09_289074	249	6	indicates	indicate	VBZ
10_1101-2020_09_09_289074	249	7	a	a	DT
10_1101-2020_09_09_289074	249	8	stop	stop	NN
10_1101-2020_09_09_289074	249	9	codon	codon	NN
10_1101-2020_09_09_289074	249	10	.	.	.
10_1101-2020_09_09_289074	250	1	A	a	DT
10_1101-2020_09_09_289074	250	2	lower	low	JJR
10_1101-2020_09_09_289074	250	3	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	250	4	score	score	NN
10_1101-2020_09_09_289074	250	5	indicates	indicate	VBZ
10_1101-2020_09_09_289074	250	6	a	a	DT
10_1101-2020_09_09_289074	250	7	stronger	strong	JJR
10_1101-2020_09_09_289074	250	8	effect	effect	NN
10_1101-2020_09_09_289074	250	9	in	in	IN
10_1101-2020_09_09_289074	250	10	the	the	DT
10_1101-2020_09_09_289074	250	11	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	250	12	/	/	SYM
10_1101-2020_09_09_289074	250	13	Spike	Spike	NNP
10_1101-2020_09_09_289074	250	14	interaction	interaction	NN
10_1101-2020_09_09_289074	250	15	.	.	.
10_1101-2020_09_09_289074	251	1	Mutation	Mutation	NNP
10_1101-2020_09_09_289074	251	2	Position	Position	NNP
10_1101-2020_09_09_289074	251	3	Abundance	Abundance	NNP
10_1101-2020_09_09_289074	251	4	Frequency	Frequency	NNP
10_1101-2020_09_09_289074	251	5	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	251	6	Average	Average	NNP
10_1101-2020_09_09_289074	251	7	Score	Score	NNP
10_1101-2020_09_09_289074	251	8	Quartile	Quartile	NNP
10_1101-2020_09_09_289074	251	9	S477N	S477N	NNP
10_1101-2020_09_09_289074	251	10	477	477	CD
10_1101-2020_09_09_289074	251	11	16547	16547	CD
10_1101-2020_09_09_289074	251	12	0.055995	0.055995	CD
10_1101-2020_09_09_289074	251	13	-18.61	-18.61	:
10_1101-2020_09_09_289074	251	14	Q2	Q2	NNP
10_1101-2020_09_09_289074	251	15	N439	N439	NNP
10_1101-2020_09_09_289074	251	16	K	K	NNP
10_1101-2020_09_09_289074	251	17	439	439	CD
10_1101-2020_09_09_289074	251	18	5587	5587	CD
10_1101-2020_09_09_289074	251	19	0.018906	0.018906	CD
10_1101-2020_09_09_289074	251	20	-11.81	-11.81	:
10_1101-2020_09_09_289074	251	21	Q2	Q2	NNP
10_1101-2020_09_09_289074	251	22	N501Y	N501Y	NNP
10_1101-2020_09_09_289074	251	23	501	501	CD
10_1101-2020_09_09_289074	251	24	4921	4921	CD
10_1101-2020_09_09_289074	251	25	0.016653	0.016653	CD
10_1101-2020_09_09_289074	251	26	-63.3975	-63.3975	:
10_1101-2020_09_09_289074	251	27	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	28	Y453F	Y453F	NNP
10_1101-2020_09_09_289074	251	29	453	453	CD
10_1101-2020_09_09_289074	251	30	917	917	CD
10_1101-2020_09_09_289074	251	31	0.003103	0.003103	CD
10_1101-2020_09_09_289074	251	32	-0.8825	-0.8825	NFP
10_1101-2020_09_09_289074	251	33	Q4	Q4	NNP
10_1101-2020_09_09_289074	251	34	E484	E484	NNP
10_1101-2020_09_09_289074	251	35	K	K	NNP
10_1101-2020_09_09_289074	251	36	484	484	CD
10_1101-2020_09_09_289074	251	37	352	352	CD
10_1101-2020_09_09_289074	251	38	0.001191	0.001191	CD
10_1101-2020_09_09_289074	251	39	-5.4375	-5.4375	NN
10_1101-2020_09_09_289074	251	40	Q3	Q3	NNP
10_1101-2020_09_09_289074	251	41	K417N	K417N	NNP
10_1101-2020_09_09_289074	251	42	417	417	CD
10_1101-2020_09_09_289074	251	43	260	260	CD
10_1101-2020_09_09_289074	251	44	0.00088	0.00088	CD
10_1101-2020_09_09_289074	251	45	-13.925	-13.925	CD
10_1101-2020_09_09_289074	251	46	Q2	q2	NN
10_1101-2020_09_09_289074	251	47	S477I	s477i	CD
10_1101-2020_09_09_289074	251	48	477	477	CD
10_1101-2020_09_09_289074	251	49	157	157	CD
10_1101-2020_09_09_289074	251	50	0.000531	0.000531	CD
10_1101-2020_09_09_289074	251	51	-18.61	-18.61	:
10_1101-2020_09_09_289074	251	52	Q2	q2	NN
10_1101-2020_09_09_289074	251	53	G446V	g446v	CD
10_1101-2020_09_09_289074	251	54	446	446	CD
10_1101-2020_09_09_289074	251	55	58	58	CD
10_1101-2020_09_09_289074	251	56	0.000196	0.000196	CD
10_1101-2020_09_09_289074	251	57	-9.6475	-9.6475	NN
10_1101-2020_09_09_289074	251	58	Q3	Q3	NNP
10_1101-2020_09_09_289074	251	59	F490S	F490S	NNP
10_1101-2020_09_09_289074	251	60	490	490	CD
10_1101-2020_09_09_289074	251	61	53	53	CD
10_1101-2020_09_09_289074	251	62	0.000179	0.000179	CD
10_1101-2020_09_09_289074	251	63	-18.07	-18.07	.
10_1101-2020_09_09_289074	251	64	Q2	q2	NN
10_1101-2020_09_09_289074	251	65	S477R	s477r	CD
10_1101-2020_09_09_289074	251	66	477	477	CD
10_1101-2020_09_09_289074	251	67	49	49	CD
10_1101-2020_09_09_289074	251	68	0.000166	0.000166	CD
10_1101-2020_09_09_289074	251	69	-18.61	-18.61	.
10_1101-2020_09_09_289074	251	70	Q2	Q2	NNP
10_1101-2020_09_09_289074	251	71	N501	N501	NNP
10_1101-2020_09_09_289074	251	72	T	T	NNP
10_1101-2020_09_09_289074	251	73	501	501	CD
10_1101-2020_09_09_289074	251	74	47	47	CD
10_1101-2020_09_09_289074	251	75	0.000159	0.000159	CD
10_1101-2020_09_09_289074	251	76	-63.3975	-63.3975	NFP
10_1101-2020_09_09_289074	251	77	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	78	L455F	L455F	NNP
10_1101-2020_09_09_289074	251	79	455	455	CD
10_1101-2020_09_09_289074	251	80	44	44	CD
10_1101-2020_09_09_289074	251	81	0.000149	0.000149	CD
10_1101-2020_09_09_289074	251	82	-14.3075	-14.3075	NN
10_1101-2020_09_09_289074	251	83	Q2	q2	NN
10_1101-2020_09_09_289074	251	84	G476S	G476S	NNP
10_1101-2020_09_09_289074	251	85	476	476	CD
10_1101-2020_09_09_289074	251	86	43	43	CD
10_1101-2020_09_09_289074	251	87	0.000146	0.000146	CD
10_1101-2020_09_09_289074	251	88	-18.3675	-18.3675	NN
10_1101-2020_09_09_289074	251	89	Q2	q2	NN
10_1101-2020_09_09_289074	251	90	E484Q	e484q	CD
10_1101-2020_09_09_289074	251	91	484	484	CD
10_1101-2020_09_09_289074	251	92	43	43	CD
10_1101-2020_09_09_289074	251	93	0.000146	0.000146	CD
10_1101-2020_09_09_289074	251	94	-5.4375	-5.4375	:
10_1101-2020_09_09_289074	251	95	Q3	Q3	NNP
10_1101-2020_09_09_289074	251	96	A475V	A475V	NNP
10_1101-2020_09_09_289074	251	97	475	475	CD
10_1101-2020_09_09_289074	251	98	35	35	CD
10_1101-2020_09_09_289074	251	99	0.000118	0.000118	CD
10_1101-2020_09_09_289074	251	100	-54.45	-54.45	:
10_1101-2020_09_09_289074	251	101	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	102	F486L	f486l	CD
10_1101-2020_09_09_289074	251	103	486	486	CD
10_1101-2020_09_09_289074	251	104	34	34	CD
10_1101-2020_09_09_289074	251	105	0.000115	0.000115	CD
10_1101-2020_09_09_289074	251	106	-42.1525	-42.1525	CD
10_1101-2020_09_09_289074	251	107	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	108	F490L	F490L	NNP
10_1101-2020_09_09_289074	251	109	490	490	CD
10_1101-2020_09_09_289074	251	110	18	18	CD
10_1101-2020_09_09_289074	251	111	6.09E-05	6.09e-05	CD
10_1101-2020_09_09_289074	251	112	-18.07	-18.07	NN
10_1101-2020_09_09_289074	251	113	Q2	Q2	NNP
10_1101-2020_09_09_289074	251	114	YQ505WK	YQ505WK	NNP
10_1101-2020_09_09_289074	251	115	505	505	CD
10_1101-2020_09_09_289074	251	116	14	14	CD
10_1101-2020_09_09_289074	251	117	4.74E-05	4.74e-05	CD
10_1101-2020_09_09_289074	251	118	-28.835	-28.835	NNP
10_1101-2020_09_09_289074	251	119	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	120	Q493L	Q493L	NNP
10_1101-2020_09_09_289074	251	121	493	493	CD
10_1101-2020_09_09_289074	251	122	12	12	CD
10_1101-2020_09_09_289074	251	123	4.06E-05	4.06e-05	CD
10_1101-2020_09_09_289074	251	124	-60.8475	-60.8475	NN
10_1101-2020_09_09_289074	251	125	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	126	V503F	V503F	NNP
10_1101-2020_09_09_289074	251	127	503	503	CD
10_1101-2020_09_09_289074	251	128	9	9	CD
10_1101-2020_09_09_289074	251	129	3.05E-05	3.05e-05	CD
10_1101-2020_09_09_289074	251	130	-4.09	-4.09	CD
10_1101-2020_09_09_289074	251	131	Q3	Q3	NNP
10_1101-2020_09_09_289074	251	132	E484A	e484a	CD
10_1101-2020_09_09_289074	251	133	484	484	CD
10_1101-2020_09_09_289074	251	134	8	8	CD
10_1101-2020_09_09_289074	251	135	2.71E-05	2.71e-05	CD
10_1101-2020_09_09_289074	251	136	-5.4375	-5.4375	NN
10_1101-2020_09_09_289074	251	137	Q3	Q3	NNP
10_1101-2020_09_09_289074	251	138	G446S	g446s	CD
10_1101-2020_09_09_289074	251	139	446	446	CD
10_1101-2020_09_09_289074	251	140	7	7	CD
10_1101-2020_09_09_289074	251	141	2.37E-05	2.37e-05	CD
10_1101-2020_09_09_289074	251	142	-9.6475	-9.6475	NN
10_1101-2020_09_09_289074	251	143	Q3	Q3	NNP
10_1101-2020_09_09_289074	251	144	E484D	E484D	NNP
10_1101-2020_09_09_289074	251	145	484	484	CD
10_1101-2020_09_09_289074	251	146	4	4	CD
10_1101-2020_09_09_289074	251	147	1.35E-05	1.35e-05	CD
10_1101-2020_09_09_289074	251	148	-5.4375	-5.4375	NN
10_1101-2020_09_09_289074	251	149	Q3	Q3	NNP
10_1101-2020_09_09_289074	251	150	Q493	Q493	NNP
10_1101-2020_09_09_289074	251	151	*	*	NFP
10_1101-2020_09_09_289074	251	152	493	493	CD
10_1101-2020_09_09_289074	251	153	4	4	CD
10_1101-2020_09_09_289074	251	154	1.35E-05	1.35e-05	CD
10_1101-2020_09_09_289074	251	155	-60.8475	-60.8475	NN
10_1101-2020_09_09_289074	251	156	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	157	Y505W	Y505W	NNP
10_1101-2020_09_09_289074	251	158	505	505	CD
10_1101-2020_09_09_289074	251	159	4	4	CD
10_1101-2020_09_09_289074	251	160	1.35E-05	1.35e-05	CD
10_1101-2020_09_09_289074	251	161	-28.835	-28.835	NNP
10_1101-2020_09_09_289074	251	162	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	163	G476A	G476A	NNP
10_1101-2020_09_09_289074	251	164	476	476	CD
10_1101-2020_09_09_289074	251	165	3	3	CD
10_1101-2020_09_09_289074	251	166	1.02E-05	1.02e-05	CD
10_1101-2020_09_09_289074	251	167	-18.3675	-18.3675	NN
10_1101-2020_09_09_289074	251	168	Q2	Q2	NNP
10_1101-2020_09_09_289074	251	169	S477	S477	NNP
10_1101-2020_09_09_289074	251	170	G	G	NNP
10_1101-2020_09_09_289074	251	171	477	477	CD
10_1101-2020_09_09_289074	251	172	3	3	CD
10_1101-2020_09_09_289074	251	173	1.02E-05	1.02e-05	CD
10_1101-2020_09_09_289074	251	174	-18.61	-18.61	.
10_1101-2020_09_09_289074	251	175	Q2	Q2	NNP
10_1101-2020_09_09_289074	251	176	F456L	f456l	CD
10_1101-2020_09_09_289074	251	177	456	456	CD
10_1101-2020_09_09_289074	251	178	2	2	CD
10_1101-2020_09_09_289074	251	179	6.77E-06	6.77e-06	CD
10_1101-2020_09_09_289074	251	180	-31.21	-31.21	:
10_1101-2020_09_09_289074	251	181	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	182	V503I	V503I	NNP
10_1101-2020_09_09_289074	251	183	503	503	CD
10_1101-2020_09_09_289074	251	184	2	2	CD
10_1101-2020_09_09_289074	251	185	6.77E-06	6.77e-06	CD
10_1101-2020_09_09_289074	251	186	-4.09	-4.09	NFP
10_1101-2020_09_09_289074	251	187	Q3	q3	NN
10_1101-2020_09_09_289074	251	188	Y449F	y449f	CD
10_1101-2020_09_09_289074	251	189	449	449	CD
10_1101-2020_09_09_289074	251	190	2	2	CD
10_1101-2020_09_09_289074	251	191	6.77E-06	6.77e-06	CD
10_1101-2020_09_09_289074	251	192	-19.3075	-19.3075	HYPH
10_1101-2020_09_09_289074	251	193	Q1	Q1	NNP
10_1101-2020_09_09_289074	251	194	.CC	.CC	:
10_1101-2020_09_09_289074	251	195	-	-	:
10_1101-2020_09_09_289074	251	196	BY	by	IN
10_1101-2020_09_09_289074	251	197	-	-	HYPH
10_1101-2020_09_09_289074	251	198	NC	NC	NNP
10_1101-2020_09_09_289074	251	199	-	-	HYPH
10_1101-2020_09_09_289074	251	200	ND	ND	NNP
10_1101-2020_09_09_289074	251	201	4.0	4.0	CD
10_1101-2020_09_09_289074	251	202	International	International	NNP
10_1101-2020_09_09_289074	251	203	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	251	204	under	under	IN
10_1101-2020_09_09_289074	251	205	a	a	DT
10_1101-2020_09_09_289074	251	206	(	(	-LRB-
10_1101-2020_09_09_289074	251	207	which	which	WDT
10_1101-2020_09_09_289074	251	208	was	be	VBD
10_1101-2020_09_09_289074	251	209	not	not	RB
10_1101-2020_09_09_289074	251	210	certified	certify	VBN
10_1101-2020_09_09_289074	251	211	by	by	IN
10_1101-2020_09_09_289074	251	212	peer	peer	NN
10_1101-2020_09_09_289074	251	213	review	review	NN
10_1101-2020_09_09_289074	251	214	)	)	-RRB-
10_1101-2020_09_09_289074	251	215	is	be	VBZ
10_1101-2020_09_09_289074	251	216	the	the	DT
10_1101-2020_09_09_289074	251	217	author	author	NN
10_1101-2020_09_09_289074	251	218	/	/	SYM
10_1101-2020_09_09_289074	251	219	funder	funder	NN
10_1101-2020_09_09_289074	251	220	,	,	,
10_1101-2020_09_09_289074	251	221	who	who	WP
10_1101-2020_09_09_289074	251	222	has	have	VBZ
10_1101-2020_09_09_289074	251	223	granted	grant	VBN
10_1101-2020_09_09_289074	251	224	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	251	225	a	a	DT
10_1101-2020_09_09_289074	251	226	license	license	NN
10_1101-2020_09_09_289074	251	227	to	to	TO
10_1101-2020_09_09_289074	251	228	display	display	VB
10_1101-2020_09_09_289074	251	229	the	the	DT
10_1101-2020_09_09_289074	251	230	preprint	preprint	NN
10_1101-2020_09_09_289074	251	231	in	in	IN
10_1101-2020_09_09_289074	251	232	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	251	233	.	.	.
10_1101-2020_09_09_289074	252	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	252	2	is	be	VBZ
10_1101-2020_09_09_289074	252	3	made	make	VBN
10_1101-2020_09_09_289074	252	4	The	the	DT
10_1101-2020_09_09_289074	252	5	copyright	copyright	NN
10_1101-2020_09_09_289074	252	6	holder	holder	NN
10_1101-2020_09_09_289074	252	7	for	for	IN
10_1101-2020_09_09_289074	252	8	this	this	DT
10_1101-2020_09_09_289074	252	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	252	10	version	version	NN
10_1101-2020_09_09_289074	252	11	posted	post	VBD
10_1101-2020_09_09_289074	252	12	January	January	NNP
10_1101-2020_09_09_289074	252	13	5	5	CD
10_1101-2020_09_09_289074	252	14	,	,	,
10_1101-2020_09_09_289074	252	15	2021	2021	CD
10_1101-2020_09_09_289074	252	16	.	.	.
10_1101-2020_09_09_289074	252	17	;	;	:
10_1101-2020_09_09_289074	252	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	252	19	:	:	:
10_1101-2020_09_09_289074	252	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	252	21	preprint	preprint	NN
10_1101-2020_09_09_289074	252	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	252	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	252	24	22	22	CD
10_1101-2020_09_09_289074	252	25	Table	table	NN
10_1101-2020_09_09_289074	252	26	5	5	CD
10_1101-2020_09_09_289074	252	27	.	.	.
10_1101-2020_09_09_289074	253	1	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	253	2	variants	variant	NNS
10_1101-2020_09_09_289074	253	3	with	with	IN
10_1101-2020_09_09_289074	253	4	non	non	JJ
10_1101-2020_09_09_289074	253	5	-	-	JJ
10_1101-2020_09_09_289074	253	6	zero	zero	CD
10_1101-2020_09_09_289074	253	7	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	253	8	score	score	NN
10_1101-2020_09_09_289074	253	9	in	in	IN
10_1101-2020_09_09_289074	253	10	the	the	DT
10_1101-2020_09_09_289074	253	11	Spike	Spike	NNP
10_1101-2020_09_09_289074	253	12	interaction	interaction	NN
10_1101-2020_09_09_289074	253	13	model	model	NN
10_1101-2020_09_09_289074	253	14	.	.	.
10_1101-2020_09_09_289074	254	1	variant	variant	JJ
10_1101-2020_09_09_289074	254	2	rsID	rsID	NNP
10_1101-2020_09_09_289074	254	3	Allele	Allele	NNP
10_1101-2020_09_09_289074	254	4	Frequency	Frequency	NNP
10_1101-2020_09_09_289074	254	5	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	254	6	Average	average	JJ
10_1101-2020_09_09_289074	254	7	Score	Score	NNP
10_1101-2020_09_09_289074	254	8	Quartile	Quartile	NNP
10_1101-2020_09_09_289074	254	9	S19P	S19P	NNP
10_1101-2020_09_09_289074	254	10	rs73635825	rs73635825	NNP
10_1101-2020_09_09_289074	254	11	0.000655	0.000655	CD
10_1101-2020_09_09_289074	254	12	-47.62	-47.62	NNP
10_1101-2020_09_09_289074	254	13	Q1	Q1	NNP
10_1101-2020_09_09_289074	254	14	E329	E329	NNP
10_1101-2020_09_09_289074	254	15	G	G	NNP
10_1101-2020_09_09_289074	254	16	rs143936283	rs143936283	NN
10_1101-2020_09_09_289074	254	17	6.63E-05	6.63e-05	CD
10_1101-2020_09_09_289074	254	18	-4.31	-4.31	CD
10_1101-2020_09_09_289074	254	19	Q3	q3	NN
10_1101-2020_09_09_289074	254	20	M82I	M82I	NNP
10_1101-2020_09_09_289074	254	21	rs766996587	rs766996587	NNP
10_1101-2020_09_09_289074	254	22	6.62E-05	6.62e-05	CD
10_1101-2020_09_09_289074	254	23	-3.09	-3.09	:
10_1101-2020_09_09_289074	254	24	Q3	Q3	NNP
10_1101-2020_09_09_289074	254	25	E37	E37	NNP
10_1101-2020_09_09_289074	254	26	K	K	NNP
10_1101-2020_09_09_289074	254	27	rs146676783	rs146676783	NNP
10_1101-2020_09_09_289074	254	28	5.68E-05	5.68e-05	CD
10_1101-2020_09_09_289074	254	29	-16.07	-16.07	NN
10_1101-2020_09_09_289074	254	30	Q2	Q2	NNP
10_1101-2020_09_09_289074	254	31	G352V	g352v	CD
10_1101-2020_09_09_289074	254	32	rs370610075	rs370610075	NNP
10_1101-2020_09_09_289074	254	33	3.8E-05	3.8e-05	CD
10_1101-2020_09_09_289074	254	34	-8.46	-8.46	CD
10_1101-2020_09_09_289074	254	35	Q2	Q2	NNP
10_1101-2020_09_09_289074	254	36	.CC	.CC	:
10_1101-2020_09_09_289074	254	37	-	-	:
10_1101-2020_09_09_289074	254	38	BY	by	IN
10_1101-2020_09_09_289074	254	39	-	-	HYPH
10_1101-2020_09_09_289074	254	40	NC	NC	NNP
10_1101-2020_09_09_289074	254	41	-	-	HYPH
10_1101-2020_09_09_289074	254	42	ND	ND	NNP
10_1101-2020_09_09_289074	254	43	4.0	4.0	CD
10_1101-2020_09_09_289074	254	44	International	International	NNP
10_1101-2020_09_09_289074	254	45	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	254	46	under	under	IN
10_1101-2020_09_09_289074	254	47	a	a	DT
10_1101-2020_09_09_289074	254	48	(	(	-LRB-
10_1101-2020_09_09_289074	254	49	which	which	WDT
10_1101-2020_09_09_289074	254	50	was	be	VBD
10_1101-2020_09_09_289074	254	51	not	not	RB
10_1101-2020_09_09_289074	254	52	certified	certify	VBN
10_1101-2020_09_09_289074	254	53	by	by	IN
10_1101-2020_09_09_289074	254	54	peer	peer	NN
10_1101-2020_09_09_289074	254	55	review	review	NN
10_1101-2020_09_09_289074	254	56	)	)	-RRB-
10_1101-2020_09_09_289074	254	57	is	be	VBZ
10_1101-2020_09_09_289074	254	58	the	the	DT
10_1101-2020_09_09_289074	254	59	author	author	NN
10_1101-2020_09_09_289074	254	60	/	/	SYM
10_1101-2020_09_09_289074	254	61	funder	funder	NN
10_1101-2020_09_09_289074	254	62	,	,	,
10_1101-2020_09_09_289074	254	63	who	who	WP
10_1101-2020_09_09_289074	254	64	has	have	VBZ
10_1101-2020_09_09_289074	254	65	granted	grant	VBN
10_1101-2020_09_09_289074	254	66	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	254	67	a	a	DT
10_1101-2020_09_09_289074	254	68	license	license	NN
10_1101-2020_09_09_289074	254	69	to	to	TO
10_1101-2020_09_09_289074	254	70	display	display	VB
10_1101-2020_09_09_289074	254	71	the	the	DT
10_1101-2020_09_09_289074	254	72	preprint	preprint	NN
10_1101-2020_09_09_289074	254	73	in	in	IN
10_1101-2020_09_09_289074	254	74	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	254	75	.	.	.
10_1101-2020_09_09_289074	255	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	255	2	is	be	VBZ
10_1101-2020_09_09_289074	255	3	made	make	VBN
10_1101-2020_09_09_289074	255	4	The	the	DT
10_1101-2020_09_09_289074	255	5	copyright	copyright	NN
10_1101-2020_09_09_289074	255	6	holder	holder	NN
10_1101-2020_09_09_289074	255	7	for	for	IN
10_1101-2020_09_09_289074	255	8	this	this	DT
10_1101-2020_09_09_289074	255	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	255	10	version	version	NN
10_1101-2020_09_09_289074	255	11	posted	post	VBD
10_1101-2020_09_09_289074	255	12	January	January	NNP
10_1101-2020_09_09_289074	255	13	5	5	CD
10_1101-2020_09_09_289074	255	14	,	,	,
10_1101-2020_09_09_289074	255	15	2021	2021	CD
10_1101-2020_09_09_289074	255	16	.	.	.
10_1101-2020_09_09_289074	255	17	;	;	:
10_1101-2020_09_09_289074	255	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	255	19	:	:	:
10_1101-2020_09_09_289074	255	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	255	21	preprint	preprint	NN
10_1101-2020_09_09_289074	255	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	ADD
10_1101-2020_09_09_289074	255	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	CD
10_1101-2020_09_09_289074	255	24	23	23	CD
10_1101-2020_09_09_289074	255	25	Supplementary	supplementary	JJ
10_1101-2020_09_09_289074	255	26	Files	file	NNS
10_1101-2020_09_09_289074	255	27	Description	description	NN
10_1101-2020_09_09_289074	255	28	Supplementary	Supplementary	NNP
10_1101-2020_09_09_289074	255	29	File	File	NNP
10_1101-2020_09_09_289074	255	30	1	1	CD
10_1101-2020_09_09_289074	255	31	:	:	:
10_1101-2020_09_09_289074	255	32	table	table	NN
10_1101-2020_09_09_289074	255	33	of	of	IN
10_1101-2020_09_09_289074	255	34	SARS	SARS	NNP
10_1101-2020_09_09_289074	255	35	-	-	HYPH
10_1101-2020_09_09_289074	255	36	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	255	37	Spike	Spike	NNP
10_1101-2020_09_09_289074	255	38	mutations	mutation	NNS
10_1101-2020_09_09_289074	255	39	(	(	-LRB-
10_1101-2020_09_09_289074	255	40	source	source	NN
10_1101-2020_09_09_289074	255	41	:	:	:
10_1101-2020_09_09_289074	255	42	GISAID	GISAID	NNP
10_1101-2020_09_09_289074	255	43	database	database	NN
10_1101-2020_09_09_289074	255	44	,	,	,
10_1101-2020_09_09_289074	255	45	29	29	CD
10_1101-2020_09_09_289074	255	46	December	December	NNP
10_1101-2020_09_09_289074	255	47	2020	2020	CD
10_1101-2020_09_09_289074	255	48	)	)	-RRB-
10_1101-2020_09_09_289074	255	49	,	,	,
10_1101-2020_09_09_289074	255	50	indicating	indicate	VBG
10_1101-2020_09_09_289074	255	51	position	position	NN
10_1101-2020_09_09_289074	255	52	,	,	,
10_1101-2020_09_09_289074	255	53	frequency	frequency	NN
10_1101-2020_09_09_289074	255	54	in	in	IN
10_1101-2020_09_09_289074	255	55	the	the	DT
10_1101-2020_09_09_289074	255	56	sequenced	sequence	VBN
10_1101-2020_09_09_289074	255	57	SARS	SARS	NNP
10_1101-2020_09_09_289074	255	58	-	-	HYPH
10_1101-2020_09_09_289074	255	59	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	255	60	genome	genome	NNP
10_1101-2020_09_09_289074	255	61	and	and	CC
10_1101-2020_09_09_289074	255	62	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	255	63	score	score	NN
10_1101-2020_09_09_289074	255	64	(	(	-LRB-
10_1101-2020_09_09_289074	255	65	lower	lower	RBR
10_1101-2020_09_09_289074	255	66	:	:	:
10_1101-2020_09_09_289074	255	67	predicted	predict	VBN
10_1101-2020_09_09_289074	255	68	stronger	strong	JJR
10_1101-2020_09_09_289074	255	69	effect	effect	NN
10_1101-2020_09_09_289074	255	70	in	in	IN
10_1101-2020_09_09_289074	255	71	the	the	DT
10_1101-2020_09_09_289074	255	72	Spike	Spike	NNP
10_1101-2020_09_09_289074	255	73	/	/	SYM
10_1101-2020_09_09_289074	255	74	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	255	75	interaction	interaction	NN
10_1101-2020_09_09_289074	255	76	)	)	-RRB-
10_1101-2020_09_09_289074	255	77	.	.	.
10_1101-2020_09_09_289074	256	1	Supplementary	Supplementary	NNP
10_1101-2020_09_09_289074	256	2	File	file	NN
10_1101-2020_09_09_289074	256	3	2	2	CD
10_1101-2020_09_09_289074	256	4	:	:	:
10_1101-2020_09_09_289074	256	5	table	table	NN
10_1101-2020_09_09_289074	256	6	of	of	IN
10_1101-2020_09_09_289074	256	7	human	human	JJ
10_1101-2020_09_09_289074	256	8	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	256	9	variants	variant	NNS
10_1101-2020_09_09_289074	256	10	(	(	-LRB-
10_1101-2020_09_09_289074	256	11	source	source	NN
10_1101-2020_09_09_289074	256	12	:	:	:
10_1101-2020_09_09_289074	256	13	gnomAD	gnomAD	NNP
10_1101-2020_09_09_289074	256	14	database	database	NN
10_1101-2020_09_09_289074	256	15	,	,	,
10_1101-2020_09_09_289074	256	16	v3	v3	NN
10_1101-2020_09_09_289074	256	17	,	,	,
10_1101-2020_09_09_289074	256	18	18	18	CD
10_1101-2020_09_09_289074	256	19	July	July	NNP
10_1101-2020_09_09_289074	256	20	2020	2020	CD
10_1101-2020_09_09_289074	256	21	)	)	-RRB-
10_1101-2020_09_09_289074	256	22	,	,	,
10_1101-2020_09_09_289074	256	23	indicating	indicate	VBG
10_1101-2020_09_09_289074	256	24	position	position	NN
10_1101-2020_09_09_289074	256	25	,	,	,
10_1101-2020_09_09_289074	256	26	frequency	frequency	NN
10_1101-2020_09_09_289074	256	27	in	in	IN
10_1101-2020_09_09_289074	256	28	the	the	DT
10_1101-2020_09_09_289074	256	29	sequenced	sequence	VBN
10_1101-2020_09_09_289074	256	30	SARS	SARS	NNP
10_1101-2020_09_09_289074	256	31	-	-	HYPH
10_1101-2020_09_09_289074	256	32	CoV-2	CoV-2	NNP
10_1101-2020_09_09_289074	256	33	genome	genome	NNP
10_1101-2020_09_09_289074	256	34	and	and	CC
10_1101-2020_09_09_289074	256	35	GBPM	GBPM	NNP
10_1101-2020_09_09_289074	256	36	score	score	NN
10_1101-2020_09_09_289074	256	37	(	(	-LRB-
10_1101-2020_09_09_289074	256	38	lower	lower	RBR
10_1101-2020_09_09_289074	256	39	:	:	:
10_1101-2020_09_09_289074	256	40	predicted	predict	VBN
10_1101-2020_09_09_289074	256	41	stronger	strong	JJR
10_1101-2020_09_09_289074	256	42	effect	effect	NN
10_1101-2020_09_09_289074	256	43	in	in	IN
10_1101-2020_09_09_289074	256	44	the	the	DT
10_1101-2020_09_09_289074	256	45	Spike	Spike	NNP
10_1101-2020_09_09_289074	256	46	/	/	SYM
10_1101-2020_09_09_289074	256	47	ACE2	ACE2	NNP
10_1101-2020_09_09_289074	256	48	interaction	interaction	NN
10_1101-2020_09_09_289074	256	49	)	)	-RRB-
10_1101-2020_09_09_289074	256	50	.	.	.
10_1101-2020_09_09_289074	257	1	Supplementary	Supplementary	NNP
10_1101-2020_09_09_289074	257	2	File	File	NNP
10_1101-2020_09_09_289074	257	3	3	3	CD
10_1101-2020_09_09_289074	257	4	:	:	:
10_1101-2020_09_09_289074	257	5	supplementary	supplementary	JJ
10_1101-2020_09_09_289074	257	6	figures	figure	NNS
10_1101-2020_09_09_289074	257	7	focusing	focus	VBG
10_1101-2020_09_09_289074	257	8	on	on	IN
10_1101-2020_09_09_289074	257	9	the	the	DT
10_1101-2020_09_09_289074	257	10	most	most	RBS
10_1101-2020_09_09_289074	257	11	relevant	relevant	JJ
10_1101-2020_09_09_289074	257	12	mutations	mutation	NNS
10_1101-2020_09_09_289074	257	13	described	describe	VBN
10_1101-2020_09_09_289074	257	14	in	in	IN
10_1101-2020_09_09_289074	257	15	this	this	DT
10_1101-2020_09_09_289074	257	16	study	study	NN
10_1101-2020_09_09_289074	257	17	,	,	,
10_1101-2020_09_09_289074	257	18	with	with	IN
10_1101-2020_09_09_289074	257	19	structural	structural	JJ
10_1101-2020_09_09_289074	257	20	,	,	,
10_1101-2020_09_09_289074	257	21	chemical	chemical	JJ
10_1101-2020_09_09_289074	257	22	and	and	CC
10_1101-2020_09_09_289074	257	23	positional	positional	JJ
10_1101-2020_09_09_289074	257	24	considerations	consideration	NNS
10_1101-2020_09_09_289074	257	25	.	.	.
10_1101-2020_09_09_289074	258	1	.CC	.CC	NFP
10_1101-2020_09_09_289074	258	2	-	-	:
10_1101-2020_09_09_289074	258	3	BY	by	IN
10_1101-2020_09_09_289074	258	4	-	-	HYPH
10_1101-2020_09_09_289074	258	5	NC	NC	NNP
10_1101-2020_09_09_289074	258	6	-	-	HYPH
10_1101-2020_09_09_289074	258	7	ND	ND	NNP
10_1101-2020_09_09_289074	258	8	4.0	4.0	CD
10_1101-2020_09_09_289074	258	9	International	International	NNP
10_1101-2020_09_09_289074	258	10	licenseavailable	licenseavailable	NN
10_1101-2020_09_09_289074	258	11	under	under	IN
10_1101-2020_09_09_289074	258	12	a	a	DT
10_1101-2020_09_09_289074	258	13	(	(	-LRB-
10_1101-2020_09_09_289074	258	14	which	which	WDT
10_1101-2020_09_09_289074	258	15	was	be	VBD
10_1101-2020_09_09_289074	258	16	not	not	RB
10_1101-2020_09_09_289074	258	17	certified	certify	VBN
10_1101-2020_09_09_289074	258	18	by	by	IN
10_1101-2020_09_09_289074	258	19	peer	peer	NN
10_1101-2020_09_09_289074	258	20	review	review	NN
10_1101-2020_09_09_289074	258	21	)	)	-RRB-
10_1101-2020_09_09_289074	258	22	is	be	VBZ
10_1101-2020_09_09_289074	258	23	the	the	DT
10_1101-2020_09_09_289074	258	24	author	author	NN
10_1101-2020_09_09_289074	258	25	/	/	SYM
10_1101-2020_09_09_289074	258	26	funder	funder	NN
10_1101-2020_09_09_289074	258	27	,	,	,
10_1101-2020_09_09_289074	258	28	who	who	WP
10_1101-2020_09_09_289074	258	29	has	have	VBZ
10_1101-2020_09_09_289074	258	30	granted	grant	VBN
10_1101-2020_09_09_289074	258	31	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	258	32	a	a	DT
10_1101-2020_09_09_289074	258	33	license	license	NN
10_1101-2020_09_09_289074	258	34	to	to	TO
10_1101-2020_09_09_289074	258	35	display	display	VB
10_1101-2020_09_09_289074	258	36	the	the	DT
10_1101-2020_09_09_289074	258	37	preprint	preprint	NN
10_1101-2020_09_09_289074	258	38	in	in	IN
10_1101-2020_09_09_289074	258	39	perpetuity	perpetuity	NN
10_1101-2020_09_09_289074	258	40	.	.	.
10_1101-2020_09_09_289074	259	1	It	-PRON-	PRP
10_1101-2020_09_09_289074	259	2	is	be	VBZ
10_1101-2020_09_09_289074	259	3	made	make	VBN
10_1101-2020_09_09_289074	259	4	The	the	DT
10_1101-2020_09_09_289074	259	5	copyright	copyright	NN
10_1101-2020_09_09_289074	259	6	holder	holder	NN
10_1101-2020_09_09_289074	259	7	for	for	IN
10_1101-2020_09_09_289074	259	8	this	this	DT
10_1101-2020_09_09_289074	259	9	preprintthis	preprintthis	NN
10_1101-2020_09_09_289074	259	10	version	version	NN
10_1101-2020_09_09_289074	259	11	posted	post	VBD
10_1101-2020_09_09_289074	259	12	January	January	NNP
10_1101-2020_09_09_289074	259	13	5	5	CD
10_1101-2020_09_09_289074	259	14	,	,	,
10_1101-2020_09_09_289074	259	15	2021	2021	CD
10_1101-2020_09_09_289074	259	16	.	.	.
10_1101-2020_09_09_289074	259	17	;	;	:
10_1101-2020_09_09_289074	259	18	https://doi.org/10.1101/2020.09.09.289074doi	https://doi.org/10.1101/2020.09.09.289074doi	ADD
10_1101-2020_09_09_289074	259	19	:	:	:
10_1101-2020_09_09_289074	259	20	bioRxiv	biorxiv	IN
10_1101-2020_09_09_289074	259	21	preprint	preprint	NN
10_1101-2020_09_09_289074	259	22	https://doi.org/10.1101/2020.09.09.289074	https://doi.org/10.1101/2020.09.09.289074	UH
10_1101-2020_09_09_289074	259	23	http://creativecommons.org/licenses/by-nc-nd/4.0/	http://creativecommons.org/licenses/by-nc-nd/4.0/	XX