id sid tid token lemma pos 10_1101-2020_03_27_012757 1 1 67941284 67941284 CD 10_1101-2020_03_27_012757 1 2 1 1 CD 10_1101-2020_03_27_012757 1 3 2 2 CD 10_1101-2020_03_27_012757 1 4 3 3 CD 10_1101-2020_03_27_012757 1 5 4 4 CD 10_1101-2020_03_27_012757 1 6 5 5 CD 10_1101-2020_03_27_012757 1 7 6 6 CD 10_1101-2020_03_27_012757 1 8 Evaluating evaluate VBG 10_1101-2020_03_27_012757 1 9 the the DT 10_1101-2020_03_27_012757 1 10 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 1 11 fidelity fidelity NN 10_1101-2020_03_27_012757 1 12 of of IN 10_1101-2020_03_27_012757 1 13 cancer cancer NN 10_1101-2020_03_27_012757 1 14 models model NNS 10_1101-2020_03_27_012757 1 15 7 7 CD 10_1101-2020_03_27_012757 1 16 8 8 CD 10_1101-2020_03_27_012757 1 17 9 9 CD 10_1101-2020_03_27_012757 1 18 Da da NN 10_1101-2020_03_27_012757 1 19 Peng1 peng1 CD 10_1101-2020_03_27_012757 1 20 * * NFP 10_1101-2020_03_27_012757 1 21 , , , 10_1101-2020_03_27_012757 1 22 Rachel Rachel NNP 10_1101-2020_03_27_012757 1 23 Gleyzer2 Gleyzer2 NNP 10_1101-2020_03_27_012757 1 24 * * NFP 10_1101-2020_03_27_012757 1 25 , , , 10_1101-2020_03_27_012757 1 26 Wen Wen NNP 10_1101-2020_03_27_012757 1 27 - - HYPH 10_1101-2020_03_27_012757 1 28 Hsin Hsin NNP 10_1101-2020_03_27_012757 1 29 Tai2 Tai2 NNP 10_1101-2020_03_27_012757 1 30 , , , 10_1101-2020_03_27_012757 1 31 Pavithra Pavithra NNP 10_1101-2020_03_27_012757 1 32 Kumar2 Kumar2 NNP 10_1101-2020_03_27_012757 1 33 , , , 10_1101-2020_03_27_012757 1 34 Qin Qin NNP 10_1101-2020_03_27_012757 1 35 Bian2 bian2 NN 10_1101-2020_03_27_012757 1 36 , , , 10_1101-2020_03_27_012757 1 37 Bradley Bradley NNP 10_1101-2020_03_27_012757 1 38 Issacs2 Issacs2 NNP 10_1101-2020_03_27_012757 1 39 , , , 10_1101-2020_03_27_012757 1 40 10 10 CD 10_1101-2020_03_27_012757 1 41 Edroaldo Edroaldo NNP 10_1101-2020_03_27_012757 1 42 Lummertz Lummertz NNP 10_1101-2020_03_27_012757 1 43 da da NNP 10_1101-2020_03_27_012757 1 44 Rocha3 Rocha3 NNP 10_1101-2020_03_27_012757 1 45 , , , 10_1101-2020_03_27_012757 1 46 Stephanie Stephanie NNP 10_1101-2020_03_27_012757 1 47 Cai1 Cai1 NNP 10_1101-2020_03_27_012757 1 48 , , , 10_1101-2020_03_27_012757 1 49 Kathleen Kathleen NNP 10_1101-2020_03_27_012757 1 50 DiNapoli4,5 DiNapoli4,5 NNS 10_1101-2020_03_27_012757 1 51 , , , 10_1101-2020_03_27_012757 1 52 Franklin Franklin NNP 10_1101-2020_03_27_012757 1 53 W W NNP 10_1101-2020_03_27_012757 1 54 Huang6 Huang6 NNP 10_1101-2020_03_27_012757 1 55 , , , 10_1101-2020_03_27_012757 1 56 11 11 CD 10_1101-2020_03_27_012757 1 57 Patrick Patrick NNP 10_1101-2020_03_27_012757 1 58 Cahan1,2,7 Cahan1,2,7 NNP 10_1101-2020_03_27_012757 1 59 12 12 CD 10_1101-2020_03_27_012757 1 60 13 13 CD 10_1101-2020_03_27_012757 1 61 1Department 1department CD 10_1101-2020_03_27_012757 1 62 of of IN 10_1101-2020_03_27_012757 1 63 Biomedical Biomedical NNP 10_1101-2020_03_27_012757 1 64 Engineering Engineering NNP 10_1101-2020_03_27_012757 1 65 , , , 10_1101-2020_03_27_012757 1 66 Johns Johns NNP 10_1101-2020_03_27_012757 1 67 Hopkins Hopkins NNP 10_1101-2020_03_27_012757 1 68 University University NNP 10_1101-2020_03_27_012757 1 69 School School NNP 10_1101-2020_03_27_012757 1 70 of of IN 10_1101-2020_03_27_012757 1 71 Medicine Medicine NNP 10_1101-2020_03_27_012757 1 72 , , , 10_1101-2020_03_27_012757 1 73 14 14 CD 10_1101-2020_03_27_012757 1 74 Baltimore Baltimore NNP 10_1101-2020_03_27_012757 1 75 MD MD NNP 10_1101-2020_03_27_012757 1 76 21205 21205 CD 10_1101-2020_03_27_012757 1 77 USA USA NNP 10_1101-2020_03_27_012757 1 78 15 15 CD 10_1101-2020_03_27_012757 1 79 16 16 CD 10_1101-2020_03_27_012757 1 80 2Institute 2institute CD 10_1101-2020_03_27_012757 1 81 for for IN 10_1101-2020_03_27_012757 1 82 Cell Cell NNP 10_1101-2020_03_27_012757 1 83 Engineering Engineering NNP 10_1101-2020_03_27_012757 1 84 , , , 10_1101-2020_03_27_012757 1 85 Johns Johns NNP 10_1101-2020_03_27_012757 1 86 Hopkins Hopkins NNP 10_1101-2020_03_27_012757 1 87 University University NNP 10_1101-2020_03_27_012757 1 88 School School NNP 10_1101-2020_03_27_012757 1 89 of of IN 10_1101-2020_03_27_012757 1 90 Medicine Medicine NNP 10_1101-2020_03_27_012757 1 91 , , , 10_1101-2020_03_27_012757 1 92 17 17 CD 10_1101-2020_03_27_012757 1 93 Baltimore Baltimore NNP 10_1101-2020_03_27_012757 1 94 MD MD NNP 10_1101-2020_03_27_012757 1 95 21205 21205 CD 10_1101-2020_03_27_012757 1 96 USA USA NNP 10_1101-2020_03_27_012757 1 97 18 18 CD 10_1101-2020_03_27_012757 1 98 19 19 CD 10_1101-2020_03_27_012757 1 99 3Department 3department CD 10_1101-2020_03_27_012757 1 100 of of IN 10_1101-2020_03_27_012757 1 101 Microbiology Microbiology NNP 10_1101-2020_03_27_012757 1 102 , , , 10_1101-2020_03_27_012757 1 103 Immunology Immunology NNP 10_1101-2020_03_27_012757 1 104 and and CC 10_1101-2020_03_27_012757 1 105 Parasitology Parasitology NNP 10_1101-2020_03_27_012757 1 106 , , , 10_1101-2020_03_27_012757 1 107 20 20 CD 10_1101-2020_03_27_012757 1 108 Federal Federal NNP 10_1101-2020_03_27_012757 1 109 University University NNP 10_1101-2020_03_27_012757 1 110 of of IN 10_1101-2020_03_27_012757 1 111 Santa Santa NNP 10_1101-2020_03_27_012757 1 112 Catarina Catarina NNP 10_1101-2020_03_27_012757 1 113 , , , 10_1101-2020_03_27_012757 1 114 Florianópolis Florianópolis NNP 10_1101-2020_03_27_012757 1 115 SC SC NNP 10_1101-2020_03_27_012757 1 116 , , , 10_1101-2020_03_27_012757 1 117 Brazil Brazil NNP 10_1101-2020_03_27_012757 1 118 21 21 CD 10_1101-2020_03_27_012757 1 119 22 22 CD 10_1101-2020_03_27_012757 1 120 4Department 4department NN 10_1101-2020_03_27_012757 1 121 of of IN 10_1101-2020_03_27_012757 1 122 Cell Cell NNP 10_1101-2020_03_27_012757 1 123 Biology Biology NNP 10_1101-2020_03_27_012757 1 124 , , , 10_1101-2020_03_27_012757 1 125 Johns Johns NNP 10_1101-2020_03_27_012757 1 126 Hopkins Hopkins NNP 10_1101-2020_03_27_012757 1 127 University University NNP 10_1101-2020_03_27_012757 1 128 School School NNP 10_1101-2020_03_27_012757 1 129 of of IN 10_1101-2020_03_27_012757 1 130 Medicine Medicine NNP 10_1101-2020_03_27_012757 1 131 , , , 10_1101-2020_03_27_012757 1 132 23 23 CD 10_1101-2020_03_27_012757 1 133 Baltimore Baltimore NNP 10_1101-2020_03_27_012757 1 134 , , , 10_1101-2020_03_27_012757 1 135 MD MD NNP 10_1101-2020_03_27_012757 1 136 21205 21205 CD 10_1101-2020_03_27_012757 1 137 USA USA NNP 10_1101-2020_03_27_012757 1 138 24 24 CD 10_1101-2020_03_27_012757 1 139 25 25 CD 10_1101-2020_03_27_012757 1 140 5Department 5department CD 10_1101-2020_03_27_012757 1 141 of of IN 10_1101-2020_03_27_012757 1 142 Electrical Electrical NNP 10_1101-2020_03_27_012757 1 143 and and CC 10_1101-2020_03_27_012757 1 144 Computer Computer NNP 10_1101-2020_03_27_012757 1 145 Engineering Engineering NNP 10_1101-2020_03_27_012757 1 146 , , , 10_1101-2020_03_27_012757 1 147 Johns Johns NNP 10_1101-2020_03_27_012757 1 148 Hopkins Hopkins NNP 10_1101-2020_03_27_012757 1 149 University University NNP 10_1101-2020_03_27_012757 1 150 , , , 10_1101-2020_03_27_012757 1 151 26 26 CD 10_1101-2020_03_27_012757 1 152 Baltimore Baltimore NNP 10_1101-2020_03_27_012757 1 153 MD MD NNP 10_1101-2020_03_27_012757 1 154 21218 21218 CD 10_1101-2020_03_27_012757 1 155 USA USA NNP 10_1101-2020_03_27_012757 1 156 27 27 CD 10_1101-2020_03_27_012757 1 157 28 28 CD 10_1101-2020_03_27_012757 1 158 6Division 6division CD 10_1101-2020_03_27_012757 1 159 of of IN 10_1101-2020_03_27_012757 1 160 Hematology Hematology NNP 10_1101-2020_03_27_012757 1 161 / / SYM 10_1101-2020_03_27_012757 1 162 Oncology Oncology NNP 10_1101-2020_03_27_012757 1 163 , , , 10_1101-2020_03_27_012757 1 164 Department Department NNP 10_1101-2020_03_27_012757 1 165 of of IN 10_1101-2020_03_27_012757 1 166 Medicine Medicine NNP 10_1101-2020_03_27_012757 1 167 ; ; : 10_1101-2020_03_27_012757 1 168 Helen Helen NNP 10_1101-2020_03_27_012757 1 169 Diller Diller NNP 10_1101-2020_03_27_012757 1 170 Family Family NNP 10_1101-2020_03_27_012757 1 171 Cancer Cancer NNP 10_1101-2020_03_27_012757 1 172 Center Center NNP 10_1101-2020_03_27_012757 1 173 ; ; : 10_1101-2020_03_27_012757 1 174 29 29 CD 10_1101-2020_03_27_012757 1 175 Bakar Bakar NNP 10_1101-2020_03_27_012757 1 176 Computational Computational NNP 10_1101-2020_03_27_012757 1 177 Health Health NNP 10_1101-2020_03_27_012757 1 178 Sciences Sciences NNPS 10_1101-2020_03_27_012757 1 179 Institute Institute NNP 10_1101-2020_03_27_012757 1 180 ; ; : 10_1101-2020_03_27_012757 1 181 Institute Institute NNP 10_1101-2020_03_27_012757 1 182 for for IN 10_1101-2020_03_27_012757 1 183 Human Human NNP 10_1101-2020_03_27_012757 1 184 Genetics Genetics NNPS 10_1101-2020_03_27_012757 1 185 ; ; : 10_1101-2020_03_27_012757 1 186 30 30 CD 10_1101-2020_03_27_012757 1 187 University University NNP 10_1101-2020_03_27_012757 1 188 of of IN 10_1101-2020_03_27_012757 1 189 California California NNP 10_1101-2020_03_27_012757 1 190 , , , 10_1101-2020_03_27_012757 1 191 San San NNP 10_1101-2020_03_27_012757 1 192 Francisco Francisco NNP 10_1101-2020_03_27_012757 1 193 , , , 10_1101-2020_03_27_012757 1 194 San San NNP 10_1101-2020_03_27_012757 1 195 Francisco Francisco NNP 10_1101-2020_03_27_012757 1 196 , , , 10_1101-2020_03_27_012757 1 197 CA CA NNP 10_1101-2020_03_27_012757 1 198 31 31 CD 10_1101-2020_03_27_012757 1 199 32 32 CD 10_1101-2020_03_27_012757 1 200 7Department 7department CD 10_1101-2020_03_27_012757 1 201 of of IN 10_1101-2020_03_27_012757 1 202 Molecular Molecular NNP 10_1101-2020_03_27_012757 1 203 Biology Biology NNP 10_1101-2020_03_27_012757 1 204 and and CC 10_1101-2020_03_27_012757 1 205 Genetics Genetics NNP 10_1101-2020_03_27_012757 1 206 , , , 10_1101-2020_03_27_012757 1 207 Johns Johns NNP 10_1101-2020_03_27_012757 1 208 Hopkins Hopkins NNP 10_1101-2020_03_27_012757 1 209 University University NNP 10_1101-2020_03_27_012757 1 210 School School NNP 10_1101-2020_03_27_012757 1 211 of of IN 10_1101-2020_03_27_012757 1 212 Medicine Medicine NNP 10_1101-2020_03_27_012757 1 213 , , , 10_1101-2020_03_27_012757 1 214 33 33 CD 10_1101-2020_03_27_012757 1 215 Baltimore Baltimore NNP 10_1101-2020_03_27_012757 1 216 MD MD NNP 10_1101-2020_03_27_012757 1 217 21205 21205 CD 10_1101-2020_03_27_012757 1 218 USA USA NNP 10_1101-2020_03_27_012757 1 219 34 34 CD 10_1101-2020_03_27_012757 1 220 35 35 CD 10_1101-2020_03_27_012757 1 221 36 36 CD 10_1101-2020_03_27_012757 1 222 * * NFP 10_1101-2020_03_27_012757 1 223 These these DT 10_1101-2020_03_27_012757 1 224 authors author NNS 10_1101-2020_03_27_012757 1 225 made make VBD 10_1101-2020_03_27_012757 1 226 equal equal JJ 10_1101-2020_03_27_012757 1 227 contributions contribution NNS 10_1101-2020_03_27_012757 1 228 . . . 10_1101-2020_03_27_012757 2 1 37 37 CD 10_1101-2020_03_27_012757 2 2 38 38 CD 10_1101-2020_03_27_012757 2 3 39 39 CD 10_1101-2020_03_27_012757 2 4 Correspondence Correspondence NNP 10_1101-2020_03_27_012757 2 5 to to IN 10_1101-2020_03_27_012757 2 6 : : : 10_1101-2020_03_27_012757 2 7 patrick.cahan@jhmi.edu patrick.cahan@jhmi.edu ADD 10_1101-2020_03_27_012757 2 8 40 40 CD 10_1101-2020_03_27_012757 2 9 41 41 CD 10_1101-2020_03_27_012757 2 10 Article article NN 10_1101-2020_03_27_012757 2 11 type type NN 10_1101-2020_03_27_012757 2 12 : : : 10_1101-2020_03_27_012757 2 13 Research research NN 10_1101-2020_03_27_012757 2 14 42 42 CD 10_1101-2020_03_27_012757 2 15 43 43 CD 10_1101-2020_03_27_012757 2 16 Website website NN 10_1101-2020_03_27_012757 2 17 : : : 10_1101-2020_03_27_012757 2 18 http://www.cahanlab.org/resources/cancerCellNet_web http://www.cahanlab.org/resources/cancercellnet_web NN 10_1101-2020_03_27_012757 2 19 44 44 CD 10_1101-2020_03_27_012757 2 20 45 45 CD 10_1101-2020_03_27_012757 2 21 Code Code NNP 10_1101-2020_03_27_012757 2 22 : : : 10_1101-2020_03_27_012757 2 23 https://github.com/pcahan1/cancerCellNet https://github.com/pcahan1/cancercellnet NN 10_1101-2020_03_27_012757 2 24 46 46 CD 10_1101-2020_03_27_012757 2 25 47 47 CD 10_1101-2020_03_27_012757 2 26 48 48 CD 10_1101-2020_03_27_012757 2 27 49 49 CD 10_1101-2020_03_27_012757 2 28 50 50 CD 10_1101-2020_03_27_012757 2 29 .CC .CC : 10_1101-2020_03_27_012757 2 30 - - HYPH 10_1101-2020_03_27_012757 2 31 BY by IN 10_1101-2020_03_27_012757 2 32 - - HYPH 10_1101-2020_03_27_012757 2 33 NC NC NNP 10_1101-2020_03_27_012757 2 34 - - HYPH 10_1101-2020_03_27_012757 2 35 ND ND NNP 10_1101-2020_03_27_012757 2 36 4.0 4.0 CD 10_1101-2020_03_27_012757 2 37 International International NNP 10_1101-2020_03_27_012757 2 38 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 2 39 under under IN 10_1101-2020_03_27_012757 2 40 a a DT 10_1101-2020_03_27_012757 2 41 ( ( -LRB- 10_1101-2020_03_27_012757 2 42 which which WDT 10_1101-2020_03_27_012757 2 43 was be VBD 10_1101-2020_03_27_012757 2 44 not not RB 10_1101-2020_03_27_012757 2 45 certified certify VBN 10_1101-2020_03_27_012757 2 46 by by IN 10_1101-2020_03_27_012757 2 47 peer peer NN 10_1101-2020_03_27_012757 2 48 review review NN 10_1101-2020_03_27_012757 2 49 ) ) -RRB- 10_1101-2020_03_27_012757 2 50 is be VBZ 10_1101-2020_03_27_012757 2 51 the the DT 10_1101-2020_03_27_012757 2 52 author author NN 10_1101-2020_03_27_012757 2 53 / / SYM 10_1101-2020_03_27_012757 2 54 funder funder NN 10_1101-2020_03_27_012757 2 55 , , , 10_1101-2020_03_27_012757 2 56 who who WP 10_1101-2020_03_27_012757 2 57 has have VBZ 10_1101-2020_03_27_012757 2 58 granted grant VBN 10_1101-2020_03_27_012757 2 59 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 2 60 a a DT 10_1101-2020_03_27_012757 2 61 license license NN 10_1101-2020_03_27_012757 2 62 to to TO 10_1101-2020_03_27_012757 2 63 display display VB 10_1101-2020_03_27_012757 2 64 the the DT 10_1101-2020_03_27_012757 2 65 preprint preprint NN 10_1101-2020_03_27_012757 2 66 in in IN 10_1101-2020_03_27_012757 2 67 perpetuity perpetuity NN 10_1101-2020_03_27_012757 2 68 . . . 10_1101-2020_03_27_012757 3 1 It -PRON- PRP 10_1101-2020_03_27_012757 3 2 is be VBZ 10_1101-2020_03_27_012757 3 3 made make VBN 10_1101-2020_03_27_012757 3 4 The the DT 10_1101-2020_03_27_012757 3 5 copyright copyright NN 10_1101-2020_03_27_012757 3 6 holder holder NN 10_1101-2020_03_27_012757 3 7 for for IN 10_1101-2020_03_27_012757 3 8 this this DT 10_1101-2020_03_27_012757 3 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 3 10 version version NN 10_1101-2020_03_27_012757 3 11 posted post VBD 10_1101-2020_03_27_012757 3 12 January January NNP 10_1101-2020_03_27_012757 3 13 9 9 CD 10_1101-2020_03_27_012757 3 14 , , , 10_1101-2020_03_27_012757 3 15 2021 2021 CD 10_1101-2020_03_27_012757 3 16 . . . 10_1101-2020_03_27_012757 3 17 ; ; : 10_1101-2020_03_27_012757 3 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 3 19 : : : 10_1101-2020_03_27_012757 3 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 3 21 preprint preprint NN 10_1101-2020_03_27_012757 3 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 3 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 3 24 2 2 CD 10_1101-2020_03_27_012757 3 25 ABSTRACT ABSTRACT NNP 10_1101-2020_03_27_012757 3 26 51 51 CD 10_1101-2020_03_27_012757 3 27 52 52 CD 10_1101-2020_03_27_012757 3 28 Background background NN 10_1101-2020_03_27_012757 3 29 : : : 10_1101-2020_03_27_012757 3 30 Cancer cancer NN 10_1101-2020_03_27_012757 3 31 researchers researcher NNS 10_1101-2020_03_27_012757 3 32 use use VBP 10_1101-2020_03_27_012757 3 33 cell cell NN 10_1101-2020_03_27_012757 3 34 lines line NNS 10_1101-2020_03_27_012757 3 35 , , , 10_1101-2020_03_27_012757 3 36 patient patient NNP 10_1101-2020_03_27_012757 3 37 derived derive VBN 10_1101-2020_03_27_012757 3 38 xenografts xenograft NNS 10_1101-2020_03_27_012757 3 39 , , , 10_1101-2020_03_27_012757 3 40 engineered engineer VBN 10_1101-2020_03_27_012757 3 41 mice mouse NNS 10_1101-2020_03_27_012757 3 42 , , , 10_1101-2020_03_27_012757 3 43 53 53 CD 10_1101-2020_03_27_012757 3 44 and and CC 10_1101-2020_03_27_012757 3 45 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 3 46 as as IN 10_1101-2020_03_27_012757 3 47 models model NNS 10_1101-2020_03_27_012757 3 48 to to TO 10_1101-2020_03_27_012757 3 49 investigate investigate VB 10_1101-2020_03_27_012757 3 50 tumor tumor NN 10_1101-2020_03_27_012757 3 51 biology biology NN 10_1101-2020_03_27_012757 3 52 and and CC 10_1101-2020_03_27_012757 3 53 to to TO 10_1101-2020_03_27_012757 3 54 identify identify VB 10_1101-2020_03_27_012757 3 55 therapies therapy NNS 10_1101-2020_03_27_012757 3 56 . . . 10_1101-2020_03_27_012757 4 1 The the DT 10_1101-2020_03_27_012757 4 2 54 54 CD 10_1101-2020_03_27_012757 4 3 generalizability generalizability NN 10_1101-2020_03_27_012757 4 4 and and CC 10_1101-2020_03_27_012757 4 5 power power NN 10_1101-2020_03_27_012757 4 6 of of IN 10_1101-2020_03_27_012757 4 7 a a DT 10_1101-2020_03_27_012757 4 8 model model NN 10_1101-2020_03_27_012757 4 9 derives derive VBZ 10_1101-2020_03_27_012757 4 10 from from IN 10_1101-2020_03_27_012757 4 11 the the DT 10_1101-2020_03_27_012757 4 12 fidelity fidelity NN 10_1101-2020_03_27_012757 4 13 with with IN 10_1101-2020_03_27_012757 4 14 which which WDT 10_1101-2020_03_27_012757 4 15 it -PRON- PRP 10_1101-2020_03_27_012757 4 16 represents represent VBZ 10_1101-2020_03_27_012757 4 17 the the DT 10_1101-2020_03_27_012757 4 18 tumor tumor NN 10_1101-2020_03_27_012757 4 19 55 55 CD 10_1101-2020_03_27_012757 4 20 type type NN 10_1101-2020_03_27_012757 4 21 under under IN 10_1101-2020_03_27_012757 4 22 investigation investigation NN 10_1101-2020_03_27_012757 4 23 , , , 10_1101-2020_03_27_012757 4 24 however however RB 10_1101-2020_03_27_012757 4 25 , , , 10_1101-2020_03_27_012757 4 26 the the DT 10_1101-2020_03_27_012757 4 27 extent extent NN 10_1101-2020_03_27_012757 4 28 to to TO 10_1101-2020_03_27_012757 4 29 which which WDT 10_1101-2020_03_27_012757 4 30 this this DT 10_1101-2020_03_27_012757 4 31 is be VBZ 10_1101-2020_03_27_012757 4 32 true true JJ 10_1101-2020_03_27_012757 4 33 is be VBZ 10_1101-2020_03_27_012757 4 34 often often RB 10_1101-2020_03_27_012757 4 35 unclear unclear JJ 10_1101-2020_03_27_012757 4 36 . . . 10_1101-2020_03_27_012757 5 1 The the DT 10_1101-2020_03_27_012757 5 2 56 56 CD 10_1101-2020_03_27_012757 5 3 preponderance preponderance NN 10_1101-2020_03_27_012757 5 4 of of IN 10_1101-2020_03_27_012757 5 5 models model NNS 10_1101-2020_03_27_012757 5 6 and and CC 10_1101-2020_03_27_012757 5 7 the the DT 10_1101-2020_03_27_012757 5 8 ability ability NN 10_1101-2020_03_27_012757 5 9 to to TO 10_1101-2020_03_27_012757 5 10 readily readily RB 10_1101-2020_03_27_012757 5 11 generate generate VB 10_1101-2020_03_27_012757 5 12 new new JJ 10_1101-2020_03_27_012757 5 13 ones one NNS 10_1101-2020_03_27_012757 5 14 has have VBZ 10_1101-2020_03_27_012757 5 15 created create VBN 10_1101-2020_03_27_012757 5 16 a a DT 10_1101-2020_03_27_012757 5 17 demand demand NN 10_1101-2020_03_27_012757 5 18 57 57 CD 10_1101-2020_03_27_012757 5 19 for for IN 10_1101-2020_03_27_012757 5 20 tools tool NNS 10_1101-2020_03_27_012757 5 21 that that WDT 10_1101-2020_03_27_012757 5 22 can can MD 10_1101-2020_03_27_012757 5 23 measure measure VB 10_1101-2020_03_27_012757 5 24 the the DT 10_1101-2020_03_27_012757 5 25 extent extent NN 10_1101-2020_03_27_012757 5 26 and and CC 10_1101-2020_03_27_012757 5 27 ways way NNS 10_1101-2020_03_27_012757 5 28 in in IN 10_1101-2020_03_27_012757 5 29 which which WDT 10_1101-2020_03_27_012757 5 30 cancer cancer NN 10_1101-2020_03_27_012757 5 31 models model NNS 10_1101-2020_03_27_012757 5 32 resemble resemble VBP 10_1101-2020_03_27_012757 5 33 or or CC 10_1101-2020_03_27_012757 5 34 diverge diverge VBP 10_1101-2020_03_27_012757 5 35 58 58 CD 10_1101-2020_03_27_012757 5 36 from from IN 10_1101-2020_03_27_012757 5 37 native native JJ 10_1101-2020_03_27_012757 5 38 tumors tumor NNS 10_1101-2020_03_27_012757 5 39 . . . 10_1101-2020_03_27_012757 6 1 59 59 CD 10_1101-2020_03_27_012757 6 2 60 60 CD 10_1101-2020_03_27_012757 6 3 Methods method NNS 10_1101-2020_03_27_012757 6 4 : : : 10_1101-2020_03_27_012757 6 5 We -PRON- PRP 10_1101-2020_03_27_012757 6 6 developed develop VBD 10_1101-2020_03_27_012757 6 7 a a DT 10_1101-2020_03_27_012757 6 8 machine machine NN 10_1101-2020_03_27_012757 6 9 learning learn VBG 10_1101-2020_03_27_012757 6 10 based base VBN 10_1101-2020_03_27_012757 6 11 computational computational JJ 10_1101-2020_03_27_012757 6 12 tool tool NN 10_1101-2020_03_27_012757 6 13 , , , 10_1101-2020_03_27_012757 6 14 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 6 15 , , , 10_1101-2020_03_27_012757 6 16 that that IN 10_1101-2020_03_27_012757 6 17 61 61 CD 10_1101-2020_03_27_012757 6 18 measures measure NNS 10_1101-2020_03_27_012757 6 19 the the DT 10_1101-2020_03_27_012757 6 20 similarity similarity NN 10_1101-2020_03_27_012757 6 21 of of IN 10_1101-2020_03_27_012757 6 22 cancer cancer NN 10_1101-2020_03_27_012757 6 23 models model NNS 10_1101-2020_03_27_012757 6 24 to to IN 10_1101-2020_03_27_012757 6 25 22 22 CD 10_1101-2020_03_27_012757 6 26 naturally naturally RB 10_1101-2020_03_27_012757 6 27 occurring occur VBG 10_1101-2020_03_27_012757 6 28 tumor tumor NN 10_1101-2020_03_27_012757 6 29 types type NNS 10_1101-2020_03_27_012757 6 30 and and CC 10_1101-2020_03_27_012757 6 31 36 36 CD 10_1101-2020_03_27_012757 6 32 subtypes subtype NNS 10_1101-2020_03_27_012757 6 33 , , , 10_1101-2020_03_27_012757 6 34 62 62 CD 10_1101-2020_03_27_012757 6 35 in in IN 10_1101-2020_03_27_012757 6 36 a a DT 10_1101-2020_03_27_012757 6 37 platform platform NN 10_1101-2020_03_27_012757 6 38 and and CC 10_1101-2020_03_27_012757 6 39 species specie VBZ 10_1101-2020_03_27_012757 6 40 agnostic agnostic JJ 10_1101-2020_03_27_012757 6 41 manner manner NN 10_1101-2020_03_27_012757 6 42 . . . 10_1101-2020_03_27_012757 7 1 We -PRON- PRP 10_1101-2020_03_27_012757 7 2 applied apply VBD 10_1101-2020_03_27_012757 7 3 this this DT 10_1101-2020_03_27_012757 7 4 tool tool NN 10_1101-2020_03_27_012757 7 5 to to IN 10_1101-2020_03_27_012757 7 6 657 657 CD 10_1101-2020_03_27_012757 7 7 cancer cancer NN 10_1101-2020_03_27_012757 7 8 cell cell NN 10_1101-2020_03_27_012757 7 9 lines line NNS 10_1101-2020_03_27_012757 7 10 , , , 10_1101-2020_03_27_012757 7 11 415 415 CD 10_1101-2020_03_27_012757 7 12 63 63 CD 10_1101-2020_03_27_012757 7 13 patient patient NN 10_1101-2020_03_27_012757 7 14 derived derive VBN 10_1101-2020_03_27_012757 7 15 xenografts xenograft NNS 10_1101-2020_03_27_012757 7 16 , , , 10_1101-2020_03_27_012757 7 17 26 26 CD 10_1101-2020_03_27_012757 7 18 distinct distinct JJ 10_1101-2020_03_27_012757 7 19 genetically genetically RB 10_1101-2020_03_27_012757 7 20 engineered engineer VBN 10_1101-2020_03_27_012757 7 21 mouse mouse NN 10_1101-2020_03_27_012757 7 22 models model NNS 10_1101-2020_03_27_012757 7 23 , , , 10_1101-2020_03_27_012757 7 24 and and CC 10_1101-2020_03_27_012757 7 25 131 131 CD 10_1101-2020_03_27_012757 7 26 64 64 CD 10_1101-2020_03_27_012757 7 27 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 7 28 . . . 10_1101-2020_03_27_012757 8 1 We -PRON- PRP 10_1101-2020_03_27_012757 8 2 validated validate VBD 10_1101-2020_03_27_012757 8 3 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 8 4 by by IN 10_1101-2020_03_27_012757 8 5 application application NN 10_1101-2020_03_27_012757 8 6 to to IN 10_1101-2020_03_27_012757 8 7 independent independent JJ 10_1101-2020_03_27_012757 8 8 data datum NNS 10_1101-2020_03_27_012757 8 9 , , , 10_1101-2020_03_27_012757 8 10 and and CC 10_1101-2020_03_27_012757 8 11 we -PRON- PRP 10_1101-2020_03_27_012757 8 12 tested test VBD 10_1101-2020_03_27_012757 8 13 65 65 CD 10_1101-2020_03_27_012757 8 14 several several JJ 10_1101-2020_03_27_012757 8 15 predictions prediction NNS 10_1101-2020_03_27_012757 8 16 with with IN 10_1101-2020_03_27_012757 8 17 immunofluorescence immunofluorescence NN 10_1101-2020_03_27_012757 8 18 . . . 10_1101-2020_03_27_012757 9 1 66 66 CD 10_1101-2020_03_27_012757 9 2 67 67 CD 10_1101-2020_03_27_012757 9 3 Results result NNS 10_1101-2020_03_27_012757 9 4 : : : 10_1101-2020_03_27_012757 9 5 We -PRON- PRP 10_1101-2020_03_27_012757 9 6 have have VBP 10_1101-2020_03_27_012757 9 7 documented document VBN 10_1101-2020_03_27_012757 9 8 the the DT 10_1101-2020_03_27_012757 9 9 cancer cancer NN 10_1101-2020_03_27_012757 9 10 models model NNS 10_1101-2020_03_27_012757 9 11 with with IN 10_1101-2020_03_27_012757 9 12 the the DT 10_1101-2020_03_27_012757 9 13 greatest great JJS 10_1101-2020_03_27_012757 9 14 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 9 15 fidelity fidelity NN 10_1101-2020_03_27_012757 9 16 to to IN 10_1101-2020_03_27_012757 9 17 68 68 CD 10_1101-2020_03_27_012757 9 18 natural natural JJ 10_1101-2020_03_27_012757 9 19 tumors tumor NNS 10_1101-2020_03_27_012757 9 20 , , , 10_1101-2020_03_27_012757 9 21 we -PRON- PRP 10_1101-2020_03_27_012757 9 22 have have VBP 10_1101-2020_03_27_012757 9 23 identified identify VBN 10_1101-2020_03_27_012757 9 24 cancers cancer NNS 10_1101-2020_03_27_012757 9 25 underserved underserve VBN 10_1101-2020_03_27_012757 9 26 by by IN 10_1101-2020_03_27_012757 9 27 adequate adequate JJ 10_1101-2020_03_27_012757 9 28 models model NNS 10_1101-2020_03_27_012757 9 29 , , , 10_1101-2020_03_27_012757 9 30 and and CC 10_1101-2020_03_27_012757 9 31 we -PRON- PRP 10_1101-2020_03_27_012757 9 32 have have VBP 10_1101-2020_03_27_012757 9 33 69 69 CD 10_1101-2020_03_27_012757 9 34 found find VBN 10_1101-2020_03_27_012757 9 35 models model NNS 10_1101-2020_03_27_012757 9 36 with with IN 10_1101-2020_03_27_012757 9 37 annotations annotation NNS 10_1101-2020_03_27_012757 9 38 that that WDT 10_1101-2020_03_27_012757 9 39 do do VBP 10_1101-2020_03_27_012757 9 40 not not RB 10_1101-2020_03_27_012757 9 41 match match VB 10_1101-2020_03_27_012757 9 42 their -PRON- PRP$ 10_1101-2020_03_27_012757 9 43 classification classification NN 10_1101-2020_03_27_012757 9 44 . . . 10_1101-2020_03_27_012757 10 1 By by IN 10_1101-2020_03_27_012757 10 2 comparing compare VBG 10_1101-2020_03_27_012757 10 3 models model NNS 10_1101-2020_03_27_012757 10 4 70 70 CD 10_1101-2020_03_27_012757 10 5 across across IN 10_1101-2020_03_27_012757 10 6 modalities modality NNS 10_1101-2020_03_27_012757 10 7 , , , 10_1101-2020_03_27_012757 10 8 we -PRON- PRP 10_1101-2020_03_27_012757 10 9 report report VBP 10_1101-2020_03_27_012757 10 10 that that IN 10_1101-2020_03_27_012757 10 11 , , , 10_1101-2020_03_27_012757 10 12 on on IN 10_1101-2020_03_27_012757 10 13 average average JJ 10_1101-2020_03_27_012757 10 14 , , , 10_1101-2020_03_27_012757 10 15 genetically genetically RB 10_1101-2020_03_27_012757 10 16 engineered engineer VBN 10_1101-2020_03_27_012757 10 17 mice mouse NNS 10_1101-2020_03_27_012757 10 18 and and CC 10_1101-2020_03_27_012757 10 19 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 10 20 have have VBP 10_1101-2020_03_27_012757 10 21 71 71 CD 10_1101-2020_03_27_012757 10 22 higher high JJR 10_1101-2020_03_27_012757 10 23 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 10 24 fidelity fidelity NN 10_1101-2020_03_27_012757 10 25 than than IN 10_1101-2020_03_27_012757 10 26 patient patient NNP 10_1101-2020_03_27_012757 10 27 derived derive VBN 10_1101-2020_03_27_012757 10 28 xenografts xenograft NNS 10_1101-2020_03_27_012757 10 29 and and CC 10_1101-2020_03_27_012757 10 30 cell cell NN 10_1101-2020_03_27_012757 10 31 lines line NNS 10_1101-2020_03_27_012757 10 32 in in IN 10_1101-2020_03_27_012757 10 33 four four CD 10_1101-2020_03_27_012757 10 34 out out IN 10_1101-2020_03_27_012757 10 35 of of IN 10_1101-2020_03_27_012757 10 36 five five CD 10_1101-2020_03_27_012757 10 37 72 72 CD 10_1101-2020_03_27_012757 10 38 tumor tumor NN 10_1101-2020_03_27_012757 10 39 types type NNS 10_1101-2020_03_27_012757 10 40 . . . 10_1101-2020_03_27_012757 11 1 However however RB 10_1101-2020_03_27_012757 11 2 , , , 10_1101-2020_03_27_012757 11 3 several several JJ 10_1101-2020_03_27_012757 11 4 patient patient NN 10_1101-2020_03_27_012757 11 5 derived derive VBN 10_1101-2020_03_27_012757 11 6 xenografts xenograft NNS 10_1101-2020_03_27_012757 11 7 and and CC 10_1101-2020_03_27_012757 11 8 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 11 9 have have VBP 10_1101-2020_03_27_012757 11 10 classification classification NN 10_1101-2020_03_27_012757 11 11 73 73 CD 10_1101-2020_03_27_012757 11 12 scores score NNS 10_1101-2020_03_27_012757 11 13 that that WDT 10_1101-2020_03_27_012757 11 14 are be VBP 10_1101-2020_03_27_012757 11 15 on on IN 10_1101-2020_03_27_012757 11 16 par par NN 10_1101-2020_03_27_012757 11 17 with with IN 10_1101-2020_03_27_012757 11 18 native native JJ 10_1101-2020_03_27_012757 11 19 tumors tumor NNS 10_1101-2020_03_27_012757 11 20 , , , 10_1101-2020_03_27_012757 11 21 highlighting highlight VBG 10_1101-2020_03_27_012757 11 22 both both CC 10_1101-2020_03_27_012757 11 23 their -PRON- PRP$ 10_1101-2020_03_27_012757 11 24 potential potential NN 10_1101-2020_03_27_012757 11 25 as as IN 10_1101-2020_03_27_012757 11 26 faithful faithful JJ 10_1101-2020_03_27_012757 11 27 model model NN 10_1101-2020_03_27_012757 11 28 74 74 CD 10_1101-2020_03_27_012757 11 29 classes class NNS 10_1101-2020_03_27_012757 11 30 and and CC 10_1101-2020_03_27_012757 11 31 their -PRON- PRP$ 10_1101-2020_03_27_012757 11 32 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 11 33 . . . 10_1101-2020_03_27_012757 12 1 75 75 CD 10_1101-2020_03_27_012757 12 2 76 76 CD 10_1101-2020_03_27_012757 12 3 Conclusions Conclusions NNPS 10_1101-2020_03_27_012757 12 4 : : : 10_1101-2020_03_27_012757 12 5 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 12 6 enables enable VBZ 10_1101-2020_03_27_012757 12 7 the the DT 10_1101-2020_03_27_012757 12 8 rapid rapid JJ 10_1101-2020_03_27_012757 12 9 assessment assessment NN 10_1101-2020_03_27_012757 12 10 of of IN 10_1101-2020_03_27_012757 12 11 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 12 12 fidelity fidelity NN 10_1101-2020_03_27_012757 12 13 of of IN 10_1101-2020_03_27_012757 12 14 tumor tumor NNP 10_1101-2020_03_27_012757 12 15 77 77 CD 10_1101-2020_03_27_012757 12 16 models model NNS 10_1101-2020_03_27_012757 12 17 . . . 10_1101-2020_03_27_012757 13 1 We -PRON- PRP 10_1101-2020_03_27_012757 13 2 have have VBP 10_1101-2020_03_27_012757 13 3 made make VBN 10_1101-2020_03_27_012757 13 4 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 13 5 available available JJ 10_1101-2020_03_27_012757 13 6 as as IN 10_1101-2020_03_27_012757 13 7 freely freely RB 10_1101-2020_03_27_012757 13 8 downloadable downloadable JJ 10_1101-2020_03_27_012757 13 9 software software NN 10_1101-2020_03_27_012757 13 10 and and CC 10_1101-2020_03_27_012757 13 11 as as IN 10_1101-2020_03_27_012757 13 12 a a DT 10_1101-2020_03_27_012757 13 13 web web NN 10_1101-2020_03_27_012757 13 14 78 78 CD 10_1101-2020_03_27_012757 13 15 application application NN 10_1101-2020_03_27_012757 13 16 that that WDT 10_1101-2020_03_27_012757 13 17 can can MD 10_1101-2020_03_27_012757 13 18 be be VB 10_1101-2020_03_27_012757 13 19 applied apply VBN 10_1101-2020_03_27_012757 13 20 to to IN 10_1101-2020_03_27_012757 13 21 new new JJ 10_1101-2020_03_27_012757 13 22 cancer cancer NN 10_1101-2020_03_27_012757 13 23 models model NNS 10_1101-2020_03_27_012757 13 24 that that WDT 10_1101-2020_03_27_012757 13 25 allows allow VBZ 10_1101-2020_03_27_012757 13 26 for for IN 10_1101-2020_03_27_012757 13 27 direct direct JJ 10_1101-2020_03_27_012757 13 28 comparison comparison NN 10_1101-2020_03_27_012757 13 29 to to IN 10_1101-2020_03_27_012757 13 30 the the DT 10_1101-2020_03_27_012757 13 31 79 79 CD 10_1101-2020_03_27_012757 13 32 cancer cancer NN 10_1101-2020_03_27_012757 13 33 models model NNS 10_1101-2020_03_27_012757 13 34 evaluated evaluate VBN 10_1101-2020_03_27_012757 13 35 here here RB 10_1101-2020_03_27_012757 13 36 . . . 10_1101-2020_03_27_012757 14 1 80 80 CD 10_1101-2020_03_27_012757 14 2 81 81 CD 10_1101-2020_03_27_012757 14 3 82 82 CD 10_1101-2020_03_27_012757 14 4 83 83 CD 10_1101-2020_03_27_012757 14 5 84 84 CD 10_1101-2020_03_27_012757 14 6 85 85 CD 10_1101-2020_03_27_012757 14 7 .CC .cc CD 10_1101-2020_03_27_012757 14 8 - - HYPH 10_1101-2020_03_27_012757 14 9 BY by IN 10_1101-2020_03_27_012757 14 10 - - HYPH 10_1101-2020_03_27_012757 14 11 NC NC NNP 10_1101-2020_03_27_012757 14 12 - - HYPH 10_1101-2020_03_27_012757 14 13 ND ND NNP 10_1101-2020_03_27_012757 14 14 4.0 4.0 CD 10_1101-2020_03_27_012757 14 15 International International NNP 10_1101-2020_03_27_012757 14 16 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 14 17 under under IN 10_1101-2020_03_27_012757 14 18 a a DT 10_1101-2020_03_27_012757 14 19 ( ( -LRB- 10_1101-2020_03_27_012757 14 20 which which WDT 10_1101-2020_03_27_012757 14 21 was be VBD 10_1101-2020_03_27_012757 14 22 not not RB 10_1101-2020_03_27_012757 14 23 certified certify VBN 10_1101-2020_03_27_012757 14 24 by by IN 10_1101-2020_03_27_012757 14 25 peer peer NN 10_1101-2020_03_27_012757 14 26 review review NN 10_1101-2020_03_27_012757 14 27 ) ) -RRB- 10_1101-2020_03_27_012757 14 28 is be VBZ 10_1101-2020_03_27_012757 14 29 the the DT 10_1101-2020_03_27_012757 14 30 author author NN 10_1101-2020_03_27_012757 14 31 / / SYM 10_1101-2020_03_27_012757 14 32 funder funder NN 10_1101-2020_03_27_012757 14 33 , , , 10_1101-2020_03_27_012757 14 34 who who WP 10_1101-2020_03_27_012757 14 35 has have VBZ 10_1101-2020_03_27_012757 14 36 granted grant VBN 10_1101-2020_03_27_012757 14 37 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 14 38 a a DT 10_1101-2020_03_27_012757 14 39 license license NN 10_1101-2020_03_27_012757 14 40 to to TO 10_1101-2020_03_27_012757 14 41 display display VB 10_1101-2020_03_27_012757 14 42 the the DT 10_1101-2020_03_27_012757 14 43 preprint preprint NN 10_1101-2020_03_27_012757 14 44 in in IN 10_1101-2020_03_27_012757 14 45 perpetuity perpetuity NN 10_1101-2020_03_27_012757 14 46 . . . 10_1101-2020_03_27_012757 15 1 It -PRON- PRP 10_1101-2020_03_27_012757 15 2 is be VBZ 10_1101-2020_03_27_012757 15 3 made make VBN 10_1101-2020_03_27_012757 15 4 The the DT 10_1101-2020_03_27_012757 15 5 copyright copyright NN 10_1101-2020_03_27_012757 15 6 holder holder NN 10_1101-2020_03_27_012757 15 7 for for IN 10_1101-2020_03_27_012757 15 8 this this DT 10_1101-2020_03_27_012757 15 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 15 10 version version NN 10_1101-2020_03_27_012757 15 11 posted post VBD 10_1101-2020_03_27_012757 15 12 January January NNP 10_1101-2020_03_27_012757 15 13 9 9 CD 10_1101-2020_03_27_012757 15 14 , , , 10_1101-2020_03_27_012757 15 15 2021 2021 CD 10_1101-2020_03_27_012757 15 16 . . . 10_1101-2020_03_27_012757 15 17 ; ; : 10_1101-2020_03_27_012757 15 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 15 19 : : : 10_1101-2020_03_27_012757 15 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 15 21 preprint preprint NN 10_1101-2020_03_27_012757 15 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 15 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 15 24 3 3 CD 10_1101-2020_03_27_012757 15 25 INTRODUCTION introduction NN 10_1101-2020_03_27_012757 15 26 86 86 CD 10_1101-2020_03_27_012757 15 27 Models model NNS 10_1101-2020_03_27_012757 15 28 are be VBP 10_1101-2020_03_27_012757 15 29 widely widely RB 10_1101-2020_03_27_012757 15 30 used use VBN 10_1101-2020_03_27_012757 15 31 to to TO 10_1101-2020_03_27_012757 15 32 investigate investigate VB 10_1101-2020_03_27_012757 15 33 cancer cancer NN 10_1101-2020_03_27_012757 15 34 biology biology NN 10_1101-2020_03_27_012757 15 35 and and CC 10_1101-2020_03_27_012757 15 36 to to TO 10_1101-2020_03_27_012757 15 37 identify identify VB 10_1101-2020_03_27_012757 15 38 potential potential JJ 10_1101-2020_03_27_012757 15 39 therapeutics therapeutic NNS 10_1101-2020_03_27_012757 15 40 . . . 10_1101-2020_03_27_012757 16 1 87 87 CD 10_1101-2020_03_27_012757 16 2 Popular popular JJ 10_1101-2020_03_27_012757 16 3 modeling modeling NN 10_1101-2020_03_27_012757 16 4 modalities modality NNS 10_1101-2020_03_27_012757 16 5 are be VBP 10_1101-2020_03_27_012757 16 6 cancer cancer NN 10_1101-2020_03_27_012757 16 7 cell cell NN 10_1101-2020_03_27_012757 16 8 lines line NNS 10_1101-2020_03_27_012757 16 9 ( ( -LRB- 10_1101-2020_03_27_012757 16 10 CCLs)1 CCLs)1 NNP 10_1101-2020_03_27_012757 16 11 , , , 10_1101-2020_03_27_012757 16 12 genetically genetically RB 10_1101-2020_03_27_012757 16 13 engineered engineer VBN 10_1101-2020_03_27_012757 16 14 mouse mouse NN 10_1101-2020_03_27_012757 16 15 88 88 CD 10_1101-2020_03_27_012757 16 16 models model NNS 10_1101-2020_03_27_012757 16 17 ( ( -LRB- 10_1101-2020_03_27_012757 16 18 GEMMs)2 gemms)2 IN 10_1101-2020_03_27_012757 16 19 , , , 10_1101-2020_03_27_012757 16 20 patient patient JJ 10_1101-2020_03_27_012757 16 21 derived derive VBN 10_1101-2020_03_27_012757 16 22 xenografts xenografts NNP 10_1101-2020_03_27_012757 16 23 ( ( -LRB- 10_1101-2020_03_27_012757 16 24 PDXs)3 PDXs)3 NNP 10_1101-2020_03_27_012757 16 25 , , , 10_1101-2020_03_27_012757 16 26 and and CC 10_1101-2020_03_27_012757 16 27 tumoroids4 tumoroids4 NNP 10_1101-2020_03_27_012757 16 28 . . . 10_1101-2020_03_27_012757 17 1 These these DT 10_1101-2020_03_27_012757 17 2 classes class NNS 10_1101-2020_03_27_012757 17 3 of of IN 10_1101-2020_03_27_012757 17 4 89 89 CD 10_1101-2020_03_27_012757 17 5 models model NNS 10_1101-2020_03_27_012757 17 6 differ differ VBP 10_1101-2020_03_27_012757 17 7 in in IN 10_1101-2020_03_27_012757 17 8 the the DT 10_1101-2020_03_27_012757 17 9 types type NNS 10_1101-2020_03_27_012757 17 10 of of IN 10_1101-2020_03_27_012757 17 11 questions question NNS 10_1101-2020_03_27_012757 17 12 that that WDT 10_1101-2020_03_27_012757 17 13 they -PRON- PRP 10_1101-2020_03_27_012757 17 14 are be VBP 10_1101-2020_03_27_012757 17 15 designed design VBN 10_1101-2020_03_27_012757 17 16 to to TO 10_1101-2020_03_27_012757 17 17 address address VB 10_1101-2020_03_27_012757 17 18 . . . 10_1101-2020_03_27_012757 18 1 CCLs ccl NNS 10_1101-2020_03_27_012757 18 2 are be VBP 10_1101-2020_03_27_012757 18 3 often often RB 10_1101-2020_03_27_012757 18 4 used use VBN 10_1101-2020_03_27_012757 18 5 90 90 CD 10_1101-2020_03_27_012757 18 6 to to TO 10_1101-2020_03_27_012757 18 7 address address VB 10_1101-2020_03_27_012757 18 8 cell cell NN 10_1101-2020_03_27_012757 18 9 intrinsic intrinsic JJ 10_1101-2020_03_27_012757 18 10 mechanistic mechanistic JJ 10_1101-2020_03_27_012757 18 11 questions5 questions5 NN 10_1101-2020_03_27_012757 18 12 , , , 10_1101-2020_03_27_012757 18 13 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 18 14 to to TO 10_1101-2020_03_27_012757 18 15 chart chart VB 10_1101-2020_03_27_012757 18 16 progression progression NN 10_1101-2020_03_27_012757 18 17 of of IN 10_1101-2020_03_27_012757 18 18 molecularly molecularly RB 10_1101-2020_03_27_012757 18 19 91 91 CD 10_1101-2020_03_27_012757 18 20 defined define VBN 10_1101-2020_03_27_012757 18 21 - - HYPH 10_1101-2020_03_27_012757 18 22 disease6 disease6 NN 10_1101-2020_03_27_012757 18 23 , , , 10_1101-2020_03_27_012757 18 24 and and CC 10_1101-2020_03_27_012757 18 25 PDXs pdx NNS 10_1101-2020_03_27_012757 18 26 to to TO 10_1101-2020_03_27_012757 18 27 explore explore VB 10_1101-2020_03_27_012757 18 28 patient patient NN 10_1101-2020_03_27_012757 18 29 - - HYPH 10_1101-2020_03_27_012757 18 30 specific specific JJ 10_1101-2020_03_27_012757 18 31 response response NN 10_1101-2020_03_27_012757 18 32 to to IN 10_1101-2020_03_27_012757 18 33 therapy therapy NN 10_1101-2020_03_27_012757 18 34 in in IN 10_1101-2020_03_27_012757 18 35 a a DT 10_1101-2020_03_27_012757 18 36 physiologically physiologically RB 10_1101-2020_03_27_012757 18 37 92 92 CD 10_1101-2020_03_27_012757 18 38 relevant relevant JJ 10_1101-2020_03_27_012757 18 39 context7 context7 NN 10_1101-2020_03_27_012757 18 40 . . . 10_1101-2020_03_27_012757 19 1 More more RBR 10_1101-2020_03_27_012757 19 2 recently recently RB 10_1101-2020_03_27_012757 19 3 , , , 10_1101-2020_03_27_012757 19 4 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 19 5 have have VBP 10_1101-2020_03_27_012757 19 6 emerged emerge VBN 10_1101-2020_03_27_012757 19 7 as as RB 10_1101-2020_03_27_012757 19 8 relatively relatively RB 10_1101-2020_03_27_012757 19 9 inexpensive inexpensive JJ 10_1101-2020_03_27_012757 19 10 , , , 10_1101-2020_03_27_012757 19 11 93 93 CD 10_1101-2020_03_27_012757 19 12 physiological physiological JJ 10_1101-2020_03_27_012757 19 13 , , , 10_1101-2020_03_27_012757 19 14 in in IN 10_1101-2020_03_27_012757 19 15 vitro vitro FW 10_1101-2020_03_27_012757 19 16 3D 3D NNP 10_1101-2020_03_27_012757 19 17 models model NNS 10_1101-2020_03_27_012757 19 18 of of IN 10_1101-2020_03_27_012757 19 19 tumor tumor NN 10_1101-2020_03_27_012757 19 20 epithelium epithelium NN 10_1101-2020_03_27_012757 19 21 with with IN 10_1101-2020_03_27_012757 19 22 applications application NNS 10_1101-2020_03_27_012757 19 23 ranging range VBG 10_1101-2020_03_27_012757 19 24 from from IN 10_1101-2020_03_27_012757 19 25 measuring measure VBG 10_1101-2020_03_27_012757 19 26 94 94 CD 10_1101-2020_03_27_012757 19 27 drug drug NN 10_1101-2020_03_27_012757 19 28 responsiveness responsiveness NN 10_1101-2020_03_27_012757 19 29 to to IN 10_1101-2020_03_27_012757 19 30 exploring explore VBG 10_1101-2020_03_27_012757 19 31 tumor tumor NN 10_1101-2020_03_27_012757 19 32 dependence dependence NN 10_1101-2020_03_27_012757 19 33 on on IN 10_1101-2020_03_27_012757 19 34 cancer cancer NN 10_1101-2020_03_27_012757 19 35 stem stem NN 10_1101-2020_03_27_012757 19 36 cells cell NNS 10_1101-2020_03_27_012757 19 37 . . . 10_1101-2020_03_27_012757 20 1 Models model NNS 10_1101-2020_03_27_012757 20 2 also also RB 10_1101-2020_03_27_012757 20 3 differ differ VBP 10_1101-2020_03_27_012757 20 4 in in IN 10_1101-2020_03_27_012757 20 5 95 95 CD 10_1101-2020_03_27_012757 20 6 the the DT 10_1101-2020_03_27_012757 20 7 extent extent NN 10_1101-2020_03_27_012757 20 8 to to TO 10_1101-2020_03_27_012757 20 9 which which WDT 10_1101-2020_03_27_012757 20 10 the the DT 10_1101-2020_03_27_012757 20 11 they -PRON- PRP 10_1101-2020_03_27_012757 20 12 represent represent VBP 10_1101-2020_03_27_012757 20 13 specific specific JJ 10_1101-2020_03_27_012757 20 14 aspects aspect NNS 10_1101-2020_03_27_012757 20 15 of of IN 10_1101-2020_03_27_012757 20 16 a a DT 10_1101-2020_03_27_012757 20 17 cancer cancer NN 10_1101-2020_03_27_012757 20 18 type8 type8 NN 10_1101-2020_03_27_012757 20 19 . . . 10_1101-2020_03_27_012757 21 1 Even even RB 10_1101-2020_03_27_012757 21 2 with with IN 10_1101-2020_03_27_012757 21 3 this this DT 10_1101-2020_03_27_012757 21 4 intra- intra- NNP 10_1101-2020_03_27_012757 21 5 96 96 CD 10_1101-2020_03_27_012757 21 6 and and CC 10_1101-2020_03_27_012757 21 7 inter inter JJ 10_1101-2020_03_27_012757 21 8 - - JJ 10_1101-2020_03_27_012757 21 9 class class JJ 10_1101-2020_03_27_012757 21 10 model model NN 10_1101-2020_03_27_012757 21 11 variation variation NN 10_1101-2020_03_27_012757 21 12 , , , 10_1101-2020_03_27_012757 21 13 all all DT 10_1101-2020_03_27_012757 21 14 models model NNS 10_1101-2020_03_27_012757 21 15 should should MD 10_1101-2020_03_27_012757 21 16 represent represent VB 10_1101-2020_03_27_012757 21 17 the the DT 10_1101-2020_03_27_012757 21 18 tumor tumor NN 10_1101-2020_03_27_012757 21 19 type type NN 10_1101-2020_03_27_012757 21 20 or or CC 10_1101-2020_03_27_012757 21 21 subtype subtype NN 10_1101-2020_03_27_012757 21 22 under under IN 10_1101-2020_03_27_012757 21 23 97 97 CD 10_1101-2020_03_27_012757 21 24 investigation investigation NN 10_1101-2020_03_27_012757 21 25 , , , 10_1101-2020_03_27_012757 21 26 and and CC 10_1101-2020_03_27_012757 21 27 not not RB 10_1101-2020_03_27_012757 21 28 another another DT 10_1101-2020_03_27_012757 21 29 type type NN 10_1101-2020_03_27_012757 21 30 of of IN 10_1101-2020_03_27_012757 21 31 tumor tumor NN 10_1101-2020_03_27_012757 21 32 , , , 10_1101-2020_03_27_012757 21 33 and and CC 10_1101-2020_03_27_012757 21 34 not not RB 10_1101-2020_03_27_012757 21 35 a a DT 10_1101-2020_03_27_012757 21 36 non non JJ 10_1101-2020_03_27_012757 21 37 - - JJ 10_1101-2020_03_27_012757 21 38 cancerous cancerous JJ 10_1101-2020_03_27_012757 21 39 tissue tissue NN 10_1101-2020_03_27_012757 21 40 . . . 10_1101-2020_03_27_012757 22 1 Therefore therefore RB 10_1101-2020_03_27_012757 22 2 , , , 10_1101-2020_03_27_012757 22 3 cancer-98 cancer-98 NN 10_1101-2020_03_27_012757 22 4 models model NNS 10_1101-2020_03_27_012757 22 5 should should MD 10_1101-2020_03_27_012757 22 6 be be VB 10_1101-2020_03_27_012757 22 7 selected select VBN 10_1101-2020_03_27_012757 22 8 not not RB 10_1101-2020_03_27_012757 22 9 only only RB 10_1101-2020_03_27_012757 22 10 based base VBN 10_1101-2020_03_27_012757 22 11 on on IN 10_1101-2020_03_27_012757 22 12 the the DT 10_1101-2020_03_27_012757 22 13 specific specific JJ 10_1101-2020_03_27_012757 22 14 biological biological JJ 10_1101-2020_03_27_012757 22 15 question question NN 10_1101-2020_03_27_012757 22 16 but but CC 10_1101-2020_03_27_012757 22 17 also also RB 10_1101-2020_03_27_012757 22 18 based base VBN 10_1101-2020_03_27_012757 22 19 on on IN 10_1101-2020_03_27_012757 22 20 99 99 CD 10_1101-2020_03_27_012757 22 21 the the DT 10_1101-2020_03_27_012757 22 22 similarity similarity NN 10_1101-2020_03_27_012757 22 23 of of IN 10_1101-2020_03_27_012757 22 24 the the DT 10_1101-2020_03_27_012757 22 25 model model NN 10_1101-2020_03_27_012757 22 26 to to IN 10_1101-2020_03_27_012757 22 27 the the DT 10_1101-2020_03_27_012757 22 28 cancer cancer NN 10_1101-2020_03_27_012757 22 29 type type NN 10_1101-2020_03_27_012757 22 30 under under IN 10_1101-2020_03_27_012757 22 31 investigation9,10 investigation9,10 NNP 10_1101-2020_03_27_012757 22 32 . . . 10_1101-2020_03_27_012757 23 1 100 100 CD 10_1101-2020_03_27_012757 23 2 Various various JJ 10_1101-2020_03_27_012757 23 3 methods method NNS 10_1101-2020_03_27_012757 23 4 have have VBP 10_1101-2020_03_27_012757 23 5 been be VBN 10_1101-2020_03_27_012757 23 6 proposed propose VBN 10_1101-2020_03_27_012757 23 7 to to TO 10_1101-2020_03_27_012757 23 8 determine determine VB 10_1101-2020_03_27_012757 23 9 the the DT 10_1101-2020_03_27_012757 23 10 similarity similarity NN 10_1101-2020_03_27_012757 23 11 of of IN 10_1101-2020_03_27_012757 23 12 cancer cancer NN 10_1101-2020_03_27_012757 23 13 models model NNS 10_1101-2020_03_27_012757 23 14 to to IN 10_1101-2020_03_27_012757 23 15 101 101 CD 10_1101-2020_03_27_012757 23 16 their -PRON- PRP$ 10_1101-2020_03_27_012757 23 17 intended intend VBN 10_1101-2020_03_27_012757 23 18 subjects subject NNS 10_1101-2020_03_27_012757 23 19 . . . 10_1101-2020_03_27_012757 24 1 Domcke Domcke NNP 10_1101-2020_03_27_012757 24 2 et et NNP 10_1101-2020_03_27_012757 24 3 al al NNP 10_1101-2020_03_27_012757 24 4 devised devise VBD 10_1101-2020_03_27_012757 24 5 a a DT 10_1101-2020_03_27_012757 24 6 ' ' `` 10_1101-2020_03_27_012757 24 7 suitability suitability NN 10_1101-2020_03_27_012757 24 8 score score NN 10_1101-2020_03_27_012757 24 9 ' ' '' 10_1101-2020_03_27_012757 24 10 as as IN 10_1101-2020_03_27_012757 24 11 a a DT 10_1101-2020_03_27_012757 24 12 metric metric NN 10_1101-2020_03_27_012757 24 13 of of IN 10_1101-2020_03_27_012757 24 14 the the DT 10_1101-2020_03_27_012757 24 15 molecular molecular JJ 10_1101-2020_03_27_012757 24 16 102 102 CD 10_1101-2020_03_27_012757 24 17 similarity similarity NN 10_1101-2020_03_27_012757 24 18 of of IN 10_1101-2020_03_27_012757 24 19 CCLs ccl NNS 10_1101-2020_03_27_012757 24 20 to to IN 10_1101-2020_03_27_012757 24 21 high high JJ 10_1101-2020_03_27_012757 24 22 grade grade NN 10_1101-2020_03_27_012757 24 23 serous serous JJ 10_1101-2020_03_27_012757 24 24 ovarian ovarian JJ 10_1101-2020_03_27_012757 24 25 carcinoma carcinoma NN 10_1101-2020_03_27_012757 24 26 based base VBN 10_1101-2020_03_27_012757 24 27 on on IN 10_1101-2020_03_27_012757 24 28 a a DT 10_1101-2020_03_27_012757 24 29 heuristic heuristic JJ 10_1101-2020_03_27_012757 24 30 weighting weighting NN 10_1101-2020_03_27_012757 24 31 of of IN 10_1101-2020_03_27_012757 24 32 103 103 CD 10_1101-2020_03_27_012757 24 33 copy copy NN 10_1101-2020_03_27_012757 24 34 number number NN 10_1101-2020_03_27_012757 24 35 alterations alteration NNS 10_1101-2020_03_27_012757 24 36 , , , 10_1101-2020_03_27_012757 24 37 mutation mutation NN 10_1101-2020_03_27_012757 24 38 status status NN 10_1101-2020_03_27_012757 24 39 of of IN 10_1101-2020_03_27_012757 24 40 several several JJ 10_1101-2020_03_27_012757 24 41 genes gene NNS 10_1101-2020_03_27_012757 24 42 that that WDT 10_1101-2020_03_27_012757 24 43 distinguish distinguish VBP 10_1101-2020_03_27_012757 24 44 ovarian ovarian JJ 10_1101-2020_03_27_012757 24 45 cancer cancer NN 10_1101-2020_03_27_012757 24 46 104 104 CD 10_1101-2020_03_27_012757 24 47 subtypes subtype NNS 10_1101-2020_03_27_012757 24 48 , , , 10_1101-2020_03_27_012757 24 49 and and CC 10_1101-2020_03_27_012757 24 50 hypermutation hypermutation NN 10_1101-2020_03_27_012757 24 51 status11 status11 NN 10_1101-2020_03_27_012757 24 52 . . . 10_1101-2020_03_27_012757 25 1 Other other JJ 10_1101-2020_03_27_012757 25 2 studies study NNS 10_1101-2020_03_27_012757 25 3 have have VBP 10_1101-2020_03_27_012757 25 4 taken take VBN 10_1101-2020_03_27_012757 25 5 analogous analogous JJ 10_1101-2020_03_27_012757 25 6 approaches approach NNS 10_1101-2020_03_27_012757 25 7 by by IN 10_1101-2020_03_27_012757 25 8 105 105 CD 10_1101-2020_03_27_012757 25 9 either either CC 10_1101-2020_03_27_012757 25 10 focusing focus VBG 10_1101-2020_03_27_012757 25 11 on on IN 10_1101-2020_03_27_012757 25 12 transcriptomic transcriptomic JJ 10_1101-2020_03_27_012757 25 13 or or CC 10_1101-2020_03_27_012757 25 14 ensemble ensemble JJ 10_1101-2020_03_27_012757 25 15 molecular molecular JJ 10_1101-2020_03_27_012757 25 16 profiles profile NNS 10_1101-2020_03_27_012757 25 17 ( ( -LRB- 10_1101-2020_03_27_012757 25 18 e.g. e.g. RB 10_1101-2020_03_27_012757 26 1 transcriptomic transcriptomic NNP 10_1101-2020_03_27_012757 26 2 and and CC 10_1101-2020_03_27_012757 26 3 copy copy VBP 10_1101-2020_03_27_012757 26 4 106 106 CD 10_1101-2020_03_27_012757 26 5 number number NN 10_1101-2020_03_27_012757 26 6 alterations alteration NNS 10_1101-2020_03_27_012757 26 7 ) ) -RRB- 10_1101-2020_03_27_012757 26 8 to to TO 10_1101-2020_03_27_012757 26 9 quantify quantify VB 10_1101-2020_03_27_012757 26 10 the the DT 10_1101-2020_03_27_012757 26 11 similarity similarity NN 10_1101-2020_03_27_012757 26 12 of of IN 10_1101-2020_03_27_012757 26 13 cell cell NN 10_1101-2020_03_27_012757 26 14 lines line NNS 10_1101-2020_03_27_012757 26 15 to to IN 10_1101-2020_03_27_012757 26 16 tumors12–14 tumors12–14 NNP 10_1101-2020_03_27_012757 26 17 . . . 10_1101-2020_03_27_012757 27 1 These these DT 10_1101-2020_03_27_012757 27 2 studies study NNS 10_1101-2020_03_27_012757 27 3 were be VBD 10_1101-2020_03_27_012757 27 4 107 107 CD 10_1101-2020_03_27_012757 27 5 tumor tumor NN 10_1101-2020_03_27_012757 27 6 - - HYPH 10_1101-2020_03_27_012757 27 7 type type NN 10_1101-2020_03_27_012757 27 8 specific specific JJ 10_1101-2020_03_27_012757 27 9 , , , 10_1101-2020_03_27_012757 27 10 focusing focus VBG 10_1101-2020_03_27_012757 27 11 on on IN 10_1101-2020_03_27_012757 27 12 CCLs CCLs NNPS 10_1101-2020_03_27_012757 27 13 that that DT 10_1101-2020_03_27_012757 27 14 model model NN 10_1101-2020_03_27_012757 27 15 , , , 10_1101-2020_03_27_012757 27 16 for for IN 10_1101-2020_03_27_012757 27 17 example example NN 10_1101-2020_03_27_012757 27 18 , , , 10_1101-2020_03_27_012757 27 19 hepatocellular hepatocellular NN 10_1101-2020_03_27_012757 27 20 carcinoma carcinoma NN 10_1101-2020_03_27_012757 27 21 or or CC 10_1101-2020_03_27_012757 27 22 108 108 CD 10_1101-2020_03_27_012757 27 23 breast breast NN 10_1101-2020_03_27_012757 27 24 cancer cancer NN 10_1101-2020_03_27_012757 27 25 . . . 10_1101-2020_03_27_012757 28 1 Notably notably RB 10_1101-2020_03_27_012757 28 2 , , , 10_1101-2020_03_27_012757 28 3 Yu Yu NNP 10_1101-2020_03_27_012757 28 4 et et NNP 10_1101-2020_03_27_012757 28 5 al al NNP 10_1101-2020_03_27_012757 28 6 compared compare VBD 10_1101-2020_03_27_012757 28 7 the the DT 10_1101-2020_03_27_012757 28 8 transcriptomes transcriptome NNS 10_1101-2020_03_27_012757 28 9 of of IN 10_1101-2020_03_27_012757 28 10 CCLs ccl NNS 10_1101-2020_03_27_012757 28 11 to to IN 10_1101-2020_03_27_012757 28 12 The the DT 10_1101-2020_03_27_012757 28 13 Cancer Cancer NNP 10_1101-2020_03_27_012757 28 14 Genome Genome NNP 10_1101-2020_03_27_012757 28 15 109 109 CD 10_1101-2020_03_27_012757 28 16 Atlas atla NNS 10_1101-2020_03_27_012757 28 17 ( ( -LRB- 10_1101-2020_03_27_012757 28 18 TCGA TCGA NNP 10_1101-2020_03_27_012757 28 19 ) ) -RRB- 10_1101-2020_03_27_012757 28 20 by by IN 10_1101-2020_03_27_012757 28 21 correlation correlation NN 10_1101-2020_03_27_012757 28 22 analysis analysis NN 10_1101-2020_03_27_012757 28 23 , , , 10_1101-2020_03_27_012757 28 24 resulting result VBG 10_1101-2020_03_27_012757 28 25 in in IN 10_1101-2020_03_27_012757 28 26 a a DT 10_1101-2020_03_27_012757 28 27 panel panel NN 10_1101-2020_03_27_012757 28 28 of of IN 10_1101-2020_03_27_012757 28 29 CCLs ccl NNS 10_1101-2020_03_27_012757 28 30 recommended recommend VBD 10_1101-2020_03_27_012757 28 31 as as IN 10_1101-2020_03_27_012757 28 32 most most JJS 10_1101-2020_03_27_012757 28 33 110 110 CD 10_1101-2020_03_27_012757 28 34 representative representative NN 10_1101-2020_03_27_012757 28 35 of of IN 10_1101-2020_03_27_012757 28 36 22 22 CD 10_1101-2020_03_27_012757 28 37 tumor tumor NN 10_1101-2020_03_27_012757 28 38 types15 types15 NN 10_1101-2020_03_27_012757 28 39 . . . 10_1101-2020_03_27_012757 29 1 Most most RBS 10_1101-2020_03_27_012757 29 2 recently recently RB 10_1101-2020_03_27_012757 29 3 , , , 10_1101-2020_03_27_012757 29 4 Najgebauer Najgebauer NNP 10_1101-2020_03_27_012757 29 5 et et NNP 10_1101-2020_03_27_012757 29 6 al16 al16 NNP 10_1101-2020_03_27_012757 29 7 and and CC 10_1101-2020_03_27_012757 29 8 Salvadores Salvadores NNP 10_1101-2020_03_27_012757 29 9 et et NNP 10_1101-2020_03_27_012757 29 10 al17 al17 NNP 10_1101-2020_03_27_012757 29 11 111 111 CD 10_1101-2020_03_27_012757 29 12 .CC .CC : 10_1101-2020_03_27_012757 29 13 - - HYPH 10_1101-2020_03_27_012757 29 14 BY by IN 10_1101-2020_03_27_012757 29 15 - - HYPH 10_1101-2020_03_27_012757 29 16 NC NC NNP 10_1101-2020_03_27_012757 29 17 - - HYPH 10_1101-2020_03_27_012757 29 18 ND ND NNP 10_1101-2020_03_27_012757 29 19 4.0 4.0 CD 10_1101-2020_03_27_012757 29 20 International International NNP 10_1101-2020_03_27_012757 29 21 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 29 22 under under IN 10_1101-2020_03_27_012757 29 23 a a DT 10_1101-2020_03_27_012757 29 24 ( ( -LRB- 10_1101-2020_03_27_012757 29 25 which which WDT 10_1101-2020_03_27_012757 29 26 was be VBD 10_1101-2020_03_27_012757 29 27 not not RB 10_1101-2020_03_27_012757 29 28 certified certify VBN 10_1101-2020_03_27_012757 29 29 by by IN 10_1101-2020_03_27_012757 29 30 peer peer NN 10_1101-2020_03_27_012757 29 31 review review NN 10_1101-2020_03_27_012757 29 32 ) ) -RRB- 10_1101-2020_03_27_012757 29 33 is be VBZ 10_1101-2020_03_27_012757 29 34 the the DT 10_1101-2020_03_27_012757 29 35 author author NN 10_1101-2020_03_27_012757 29 36 / / SYM 10_1101-2020_03_27_012757 29 37 funder funder NN 10_1101-2020_03_27_012757 29 38 , , , 10_1101-2020_03_27_012757 29 39 who who WP 10_1101-2020_03_27_012757 29 40 has have VBZ 10_1101-2020_03_27_012757 29 41 granted grant VBN 10_1101-2020_03_27_012757 29 42 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 29 43 a a DT 10_1101-2020_03_27_012757 29 44 license license NN 10_1101-2020_03_27_012757 29 45 to to TO 10_1101-2020_03_27_012757 29 46 display display VB 10_1101-2020_03_27_012757 29 47 the the DT 10_1101-2020_03_27_012757 29 48 preprint preprint NN 10_1101-2020_03_27_012757 29 49 in in IN 10_1101-2020_03_27_012757 29 50 perpetuity perpetuity NN 10_1101-2020_03_27_012757 29 51 . . . 10_1101-2020_03_27_012757 30 1 It -PRON- PRP 10_1101-2020_03_27_012757 30 2 is be VBZ 10_1101-2020_03_27_012757 30 3 made make VBN 10_1101-2020_03_27_012757 30 4 The the DT 10_1101-2020_03_27_012757 30 5 copyright copyright NN 10_1101-2020_03_27_012757 30 6 holder holder NN 10_1101-2020_03_27_012757 30 7 for for IN 10_1101-2020_03_27_012757 30 8 this this DT 10_1101-2020_03_27_012757 30 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 30 10 version version NN 10_1101-2020_03_27_012757 30 11 posted post VBD 10_1101-2020_03_27_012757 30 12 January January NNP 10_1101-2020_03_27_012757 30 13 9 9 CD 10_1101-2020_03_27_012757 30 14 , , , 10_1101-2020_03_27_012757 30 15 2021 2021 CD 10_1101-2020_03_27_012757 30 16 . . . 10_1101-2020_03_27_012757 30 17 ; ; : 10_1101-2020_03_27_012757 30 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 30 19 : : : 10_1101-2020_03_27_012757 30 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 30 21 preprint preprint NN 10_1101-2020_03_27_012757 30 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 30 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 30 24 4 4 CD 10_1101-2020_03_27_012757 30 25 have have VBP 10_1101-2020_03_27_012757 30 26 developed develop VBN 10_1101-2020_03_27_012757 30 27 methods method NNS 10_1101-2020_03_27_012757 30 28 to to TO 10_1101-2020_03_27_012757 30 29 assess assess VB 10_1101-2020_03_27_012757 30 30 CCLs ccl NNS 10_1101-2020_03_27_012757 30 31 using use VBG 10_1101-2020_03_27_012757 30 32 molecular molecular JJ 10_1101-2020_03_27_012757 30 33 traits trait NNS 10_1101-2020_03_27_012757 30 34 such such JJ 10_1101-2020_03_27_012757 30 35 as as IN 10_1101-2020_03_27_012757 30 36 copy copy NN 10_1101-2020_03_27_012757 30 37 number number NN 10_1101-2020_03_27_012757 30 38 112 112 CD 10_1101-2020_03_27_012757 30 39 alterations alteration NNS 10_1101-2020_03_27_012757 30 40 ( ( -LRB- 10_1101-2020_03_27_012757 30 41 CNA CNA NNP 10_1101-2020_03_27_012757 30 42 ) ) -RRB- 10_1101-2020_03_27_012757 30 43 , , , 10_1101-2020_03_27_012757 30 44 somatic somatic JJ 10_1101-2020_03_27_012757 30 45 mutations mutation NNS 10_1101-2020_03_27_012757 30 46 , , , 10_1101-2020_03_27_012757 30 47 DNA dna NN 10_1101-2020_03_27_012757 30 48 methylation methylation NN 10_1101-2020_03_27_012757 30 49 and and CC 10_1101-2020_03_27_012757 30 50 transcriptomics transcriptomic NNS 10_1101-2020_03_27_012757 30 51 . . . 10_1101-2020_03_27_012757 31 1 While while IN 10_1101-2020_03_27_012757 31 2 all all DT 10_1101-2020_03_27_012757 31 3 of of IN 10_1101-2020_03_27_012757 31 4 these these DT 10_1101-2020_03_27_012757 31 5 113 113 CD 10_1101-2020_03_27_012757 31 6 studies study NNS 10_1101-2020_03_27_012757 31 7 have have VBP 10_1101-2020_03_27_012757 31 8 provided provide VBN 10_1101-2020_03_27_012757 31 9 valuable valuable JJ 10_1101-2020_03_27_012757 31 10 information information NN 10_1101-2020_03_27_012757 31 11 , , , 10_1101-2020_03_27_012757 31 12 they -PRON- PRP 10_1101-2020_03_27_012757 31 13 leave leave VBP 10_1101-2020_03_27_012757 31 14 two two CD 10_1101-2020_03_27_012757 31 15 major major JJ 10_1101-2020_03_27_012757 31 16 challenges challenge NNS 10_1101-2020_03_27_012757 31 17 unmet unmet VBP 10_1101-2020_03_27_012757 31 18 . . . 10_1101-2020_03_27_012757 32 1 The the DT 10_1101-2020_03_27_012757 32 2 first first JJ 10_1101-2020_03_27_012757 32 3 114 114 CD 10_1101-2020_03_27_012757 32 4 challenge challenge NN 10_1101-2020_03_27_012757 32 5 is be VBZ 10_1101-2020_03_27_012757 32 6 to to TO 10_1101-2020_03_27_012757 32 7 determine determine VB 10_1101-2020_03_27_012757 32 8 the the DT 10_1101-2020_03_27_012757 32 9 fidelity fidelity NN 10_1101-2020_03_27_012757 32 10 of of IN 10_1101-2020_03_27_012757 32 11 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 32 12 , , , 10_1101-2020_03_27_012757 32 13 PDXs pdx NNS 10_1101-2020_03_27_012757 32 14 , , , 10_1101-2020_03_27_012757 32 15 and and CC 10_1101-2020_03_27_012757 32 16 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 32 17 , , , 10_1101-2020_03_27_012757 32 18 and and CC 10_1101-2020_03_27_012757 32 19 whether whether IN 10_1101-2020_03_27_012757 32 20 there there EX 10_1101-2020_03_27_012757 32 21 are be VBP 10_1101-2020_03_27_012757 32 22 115 115 CD 10_1101-2020_03_27_012757 32 23 stark stark JJ 10_1101-2020_03_27_012757 32 24 differences difference NNS 10_1101-2020_03_27_012757 32 25 between between IN 10_1101-2020_03_27_012757 32 26 these these DT 10_1101-2020_03_27_012757 32 27 classes class NNS 10_1101-2020_03_27_012757 32 28 of of IN 10_1101-2020_03_27_012757 32 29 models model NNS 10_1101-2020_03_27_012757 32 30 and and CC 10_1101-2020_03_27_012757 32 31 CCLs ccl NNS 10_1101-2020_03_27_012757 32 32 . . . 10_1101-2020_03_27_012757 33 1 The the DT 10_1101-2020_03_27_012757 33 2 other other JJ 10_1101-2020_03_27_012757 33 3 major major JJ 10_1101-2020_03_27_012757 33 4 unmet unmet NN 10_1101-2020_03_27_012757 33 5 challenge challenge NN 10_1101-2020_03_27_012757 33 6 116 116 CD 10_1101-2020_03_27_012757 33 7 is be VBZ 10_1101-2020_03_27_012757 33 8 to to TO 10_1101-2020_03_27_012757 33 9 enable enable VB 10_1101-2020_03_27_012757 33 10 the the DT 10_1101-2020_03_27_012757 33 11 rapid rapid JJ 10_1101-2020_03_27_012757 33 12 assessment assessment NN 10_1101-2020_03_27_012757 33 13 of of IN 10_1101-2020_03_27_012757 33 14 new new JJ 10_1101-2020_03_27_012757 33 15 , , , 10_1101-2020_03_27_012757 33 16 emerging emerge VBG 10_1101-2020_03_27_012757 33 17 cancer cancer NN 10_1101-2020_03_27_012757 33 18 models model NNS 10_1101-2020_03_27_012757 33 19 . . . 10_1101-2020_03_27_012757 34 1 This this DT 10_1101-2020_03_27_012757 34 2 challenge challenge NN 10_1101-2020_03_27_012757 34 3 is be VBZ 10_1101-2020_03_27_012757 34 4 especially especially RB 10_1101-2020_03_27_012757 34 5 117 117 CD 10_1101-2020_03_27_012757 34 6 relevant relevant JJ 10_1101-2020_03_27_012757 34 7 now now RB 10_1101-2020_03_27_012757 34 8 as as IN 10_1101-2020_03_27_012757 34 9 technical technical JJ 10_1101-2020_03_27_012757 34 10 barriers barrier NNS 10_1101-2020_03_27_012757 34 11 to to IN 10_1101-2020_03_27_012757 34 12 generating generating NN 10_1101-2020_03_27_012757 34 13 models model NNS 10_1101-2020_03_27_012757 34 14 have have VBP 10_1101-2020_03_27_012757 34 15 been be VBN 10_1101-2020_03_27_012757 34 16 substantially substantially RB 10_1101-2020_03_27_012757 34 17 lowered18,19 lowered18,19 JJ 10_1101-2020_03_27_012757 34 18 , , , 10_1101-2020_03_27_012757 34 19 118 118 CD 10_1101-2020_03_27_012757 34 20 and and CC 10_1101-2020_03_27_012757 34 21 because because IN 10_1101-2020_03_27_012757 34 22 new new JJ 10_1101-2020_03_27_012757 34 23 models model NNS 10_1101-2020_03_27_012757 34 24 such such JJ 10_1101-2020_03_27_012757 34 25 as as IN 10_1101-2020_03_27_012757 34 26 PDXs pdx NNS 10_1101-2020_03_27_012757 34 27 and and CC 10_1101-2020_03_27_012757 34 28 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 34 29 can can MD 10_1101-2020_03_27_012757 34 30 be be VB 10_1101-2020_03_27_012757 34 31 derived derive VBN 10_1101-2020_03_27_012757 34 32 on on IN 10_1101-2020_03_27_012757 34 33 patient patient NN 10_1101-2020_03_27_012757 34 34 - - HYPH 10_1101-2020_03_27_012757 34 35 specific specific JJ 10_1101-2020_03_27_012757 34 36 basis basis NN 10_1101-2020_03_27_012757 34 37 119 119 CD 10_1101-2020_03_27_012757 34 38 therefore therefore RB 10_1101-2020_03_27_012757 34 39 should should MD 10_1101-2020_03_27_012757 34 40 be be VB 10_1101-2020_03_27_012757 34 41 considered consider VBN 10_1101-2020_03_27_012757 34 42 a a DT 10_1101-2020_03_27_012757 34 43 distinct distinct JJ 10_1101-2020_03_27_012757 34 44 entity entity NN 10_1101-2020_03_27_012757 34 45 requiring require VBG 10_1101-2020_03_27_012757 34 46 individual individual JJ 10_1101-2020_03_27_012757 34 47 validation4,20 validation4,20 NNP 10_1101-2020_03_27_012757 34 48 . . . 10_1101-2020_03_27_012757 35 1 120 120 CD 10_1101-2020_03_27_012757 35 2 To to TO 10_1101-2020_03_27_012757 35 3 address address VB 10_1101-2020_03_27_012757 35 4 these these DT 10_1101-2020_03_27_012757 35 5 challenges challenge NNS 10_1101-2020_03_27_012757 35 6 , , , 10_1101-2020_03_27_012757 35 7 we -PRON- PRP 10_1101-2020_03_27_012757 35 8 developed develop VBD 10_1101-2020_03_27_012757 35 9 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 35 10 ( ( -LRB- 10_1101-2020_03_27_012757 35 11 CCN CCN NNP 10_1101-2020_03_27_012757 35 12 ) ) -RRB- 10_1101-2020_03_27_012757 35 13 , , , 10_1101-2020_03_27_012757 35 14 a a DT 10_1101-2020_03_27_012757 35 15 computational computational JJ 10_1101-2020_03_27_012757 35 16 tool tool NN 10_1101-2020_03_27_012757 35 17 121 121 CD 10_1101-2020_03_27_012757 35 18 that that WDT 10_1101-2020_03_27_012757 35 19 uses use VBZ 10_1101-2020_03_27_012757 35 20 transcriptomic transcriptomic JJ 10_1101-2020_03_27_012757 35 21 data datum NNS 10_1101-2020_03_27_012757 35 22 to to TO 10_1101-2020_03_27_012757 35 23 quantitatively quantitatively RB 10_1101-2020_03_27_012757 35 24 assess assess VB 10_1101-2020_03_27_012757 35 25 the the DT 10_1101-2020_03_27_012757 35 26 similarity similarity NN 10_1101-2020_03_27_012757 35 27 between between IN 10_1101-2020_03_27_012757 35 28 cancer cancer NN 10_1101-2020_03_27_012757 35 29 models model NNS 10_1101-2020_03_27_012757 35 30 and and CC 10_1101-2020_03_27_012757 35 31 122 122 CD 10_1101-2020_03_27_012757 35 32 22 22 CD 10_1101-2020_03_27_012757 35 33 naturally naturally RB 10_1101-2020_03_27_012757 35 34 occurring occur VBG 10_1101-2020_03_27_012757 35 35 tumor tumor NN 10_1101-2020_03_27_012757 35 36 types type NNS 10_1101-2020_03_27_012757 35 37 and and CC 10_1101-2020_03_27_012757 35 38 36 36 CD 10_1101-2020_03_27_012757 35 39 subtypes subtype NNS 10_1101-2020_03_27_012757 35 40 in in IN 10_1101-2020_03_27_012757 35 41 a a DT 10_1101-2020_03_27_012757 35 42 platform- platform- NN 10_1101-2020_03_27_012757 35 43 and and CC 10_1101-2020_03_27_012757 35 44 species species NN 10_1101-2020_03_27_012757 35 45 - - HYPH 10_1101-2020_03_27_012757 35 46 agnostic agnostic JJ 10_1101-2020_03_27_012757 35 47 manner manner NN 10_1101-2020_03_27_012757 35 48 . . . 10_1101-2020_03_27_012757 36 1 123 123 CD 10_1101-2020_03_27_012757 36 2 Here here RB 10_1101-2020_03_27_012757 36 3 , , , 10_1101-2020_03_27_012757 36 4 we -PRON- PRP 10_1101-2020_03_27_012757 36 5 describe describe VBP 10_1101-2020_03_27_012757 36 6 CCN CCN NNP 10_1101-2020_03_27_012757 36 7 ’s ’s POS 10_1101-2020_03_27_012757 36 8 performance performance NN 10_1101-2020_03_27_012757 36 9 , , , 10_1101-2020_03_27_012757 36 10 and and CC 10_1101-2020_03_27_012757 36 11 the the DT 10_1101-2020_03_27_012757 36 12 results result NNS 10_1101-2020_03_27_012757 36 13 of of IN 10_1101-2020_03_27_012757 36 14 applying apply VBG 10_1101-2020_03_27_012757 36 15 it -PRON- PRP 10_1101-2020_03_27_012757 36 16 to to TO 10_1101-2020_03_27_012757 36 17 assess assess VB 10_1101-2020_03_27_012757 36 18 657 657 CD 10_1101-2020_03_27_012757 36 19 CCLs ccl NNS 10_1101-2020_03_27_012757 36 20 , , , 10_1101-2020_03_27_012757 36 21 415 415 CD 10_1101-2020_03_27_012757 36 22 124 124 CD 10_1101-2020_03_27_012757 36 23 PDXs pdx NNS 10_1101-2020_03_27_012757 36 24 , , , 10_1101-2020_03_27_012757 36 25 26 26 CD 10_1101-2020_03_27_012757 36 26 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 36 27 , , , 10_1101-2020_03_27_012757 36 28 and and CC 10_1101-2020_03_27_012757 36 29 131 131 CD 10_1101-2020_03_27_012757 36 30 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 36 31 . . . 10_1101-2020_03_27_012757 37 1 This this DT 10_1101-2020_03_27_012757 37 2 has have VBZ 10_1101-2020_03_27_012757 37 3 allowed allow VBN 10_1101-2020_03_27_012757 37 4 us -PRON- PRP 10_1101-2020_03_27_012757 37 5 to to TO 10_1101-2020_03_27_012757 37 6 identify identify VB 10_1101-2020_03_27_012757 37 7 the the DT 10_1101-2020_03_27_012757 37 8 most most RBS 10_1101-2020_03_27_012757 37 9 faithful faithful JJ 10_1101-2020_03_27_012757 37 10 models model NNS 10_1101-2020_03_27_012757 37 11 125 125 CD 10_1101-2020_03_27_012757 37 12 currently currently RB 10_1101-2020_03_27_012757 37 13 available available JJ 10_1101-2020_03_27_012757 37 14 , , , 10_1101-2020_03_27_012757 37 15 to to IN 10_1101-2020_03_27_012757 37 16 document document VB 10_1101-2020_03_27_012757 37 17 cancers cancer NNS 10_1101-2020_03_27_012757 37 18 underserved underserve VBN 10_1101-2020_03_27_012757 37 19 by by IN 10_1101-2020_03_27_012757 37 20 adequate adequate JJ 10_1101-2020_03_27_012757 37 21 models model NNS 10_1101-2020_03_27_012757 37 22 , , , 10_1101-2020_03_27_012757 37 23 and and CC 10_1101-2020_03_27_012757 37 24 to to TO 10_1101-2020_03_27_012757 37 25 find find VB 10_1101-2020_03_27_012757 37 26 models model NNS 10_1101-2020_03_27_012757 37 27 126 126 CD 10_1101-2020_03_27_012757 37 28 with with IN 10_1101-2020_03_27_012757 37 29 inaccurate inaccurate JJ 10_1101-2020_03_27_012757 37 30 tumor tumor NN 10_1101-2020_03_27_012757 37 31 type type NN 10_1101-2020_03_27_012757 37 32 annotation annotation NN 10_1101-2020_03_27_012757 37 33 . . . 10_1101-2020_03_27_012757 38 1 Moreover moreover RB 10_1101-2020_03_27_012757 38 2 , , , 10_1101-2020_03_27_012757 38 3 because because IN 10_1101-2020_03_27_012757 38 4 CCN CCN NNP 10_1101-2020_03_27_012757 38 5 is be VBZ 10_1101-2020_03_27_012757 38 6 open open JJ 10_1101-2020_03_27_012757 38 7 - - HYPH 10_1101-2020_03_27_012757 38 8 source source NN 10_1101-2020_03_27_012757 38 9 and and CC 10_1101-2020_03_27_012757 38 10 easy easy JJ 10_1101-2020_03_27_012757 38 11 to to TO 10_1101-2020_03_27_012757 38 12 127 127 CD 10_1101-2020_03_27_012757 38 13 use use NN 10_1101-2020_03_27_012757 38 14 , , , 10_1101-2020_03_27_012757 38 15 it -PRON- PRP 10_1101-2020_03_27_012757 38 16 can can MD 10_1101-2020_03_27_012757 38 17 be be VB 10_1101-2020_03_27_012757 38 18 readily readily RB 10_1101-2020_03_27_012757 38 19 applied apply VBN 10_1101-2020_03_27_012757 38 20 to to IN 10_1101-2020_03_27_012757 38 21 newly newly RB 10_1101-2020_03_27_012757 38 22 generated generate VBN 10_1101-2020_03_27_012757 38 23 cancer cancer NN 10_1101-2020_03_27_012757 38 24 models model NNS 10_1101-2020_03_27_012757 38 25 as as IN 10_1101-2020_03_27_012757 38 26 a a DT 10_1101-2020_03_27_012757 38 27 means means NN 10_1101-2020_03_27_012757 38 28 to to TO 10_1101-2020_03_27_012757 38 29 assess assess VB 10_1101-2020_03_27_012757 38 30 their -PRON- PRP$ 10_1101-2020_03_27_012757 38 31 128 128 CD 10_1101-2020_03_27_012757 38 32 fidelity fidelity NN 10_1101-2020_03_27_012757 38 33 . . . 10_1101-2020_03_27_012757 39 1 129 129 CD 10_1101-2020_03_27_012757 39 2 130 130 CD 10_1101-2020_03_27_012757 39 3 RESULTS results NN 10_1101-2020_03_27_012757 39 4 131 131 CD 10_1101-2020_03_27_012757 39 5 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 39 6 classifies classifie NNS 10_1101-2020_03_27_012757 39 7 samples sample NNS 10_1101-2020_03_27_012757 39 8 accurately accurately RB 10_1101-2020_03_27_012757 39 9 across across IN 10_1101-2020_03_27_012757 39 10 species specie NNS 10_1101-2020_03_27_012757 39 11 and and CC 10_1101-2020_03_27_012757 39 12 technologies technology NNS 10_1101-2020_03_27_012757 39 13 132 132 CD 10_1101-2020_03_27_012757 39 14 Previously previously RB 10_1101-2020_03_27_012757 39 15 , , , 10_1101-2020_03_27_012757 39 16 we -PRON- PRP 10_1101-2020_03_27_012757 39 17 had have VBD 10_1101-2020_03_27_012757 39 18 developed develop VBN 10_1101-2020_03_27_012757 39 19 a a DT 10_1101-2020_03_27_012757 39 20 computational computational JJ 10_1101-2020_03_27_012757 39 21 tool tool NN 10_1101-2020_03_27_012757 39 22 using use VBG 10_1101-2020_03_27_012757 39 23 the the DT 10_1101-2020_03_27_012757 39 24 Random Random NNP 10_1101-2020_03_27_012757 39 25 Forest Forest NNP 10_1101-2020_03_27_012757 39 26 133 133 CD 10_1101-2020_03_27_012757 39 27 classification classification NN 10_1101-2020_03_27_012757 39 28 method method NN 10_1101-2020_03_27_012757 39 29 to to TO 10_1101-2020_03_27_012757 39 30 measure measure VB 10_1101-2020_03_27_012757 39 31 the the DT 10_1101-2020_03_27_012757 39 32 similarity similarity NN 10_1101-2020_03_27_012757 39 33 of of IN 10_1101-2020_03_27_012757 39 34 engineered engineer VBN 10_1101-2020_03_27_012757 39 35 cell cell NN 10_1101-2020_03_27_012757 39 36 populations population NNS 10_1101-2020_03_27_012757 39 37 to to IN 10_1101-2020_03_27_012757 39 38 their -PRON- PRP$ 10_1101-2020_03_27_012757 39 39 in in IN 10_1101-2020_03_27_012757 39 40 vivo vivo NNP 10_1101-2020_03_27_012757 39 41 134 134 CD 10_1101-2020_03_27_012757 39 42 counterparts counterpart NNS 10_1101-2020_03_27_012757 39 43 based base VBN 10_1101-2020_03_27_012757 39 44 on on IN 10_1101-2020_03_27_012757 39 45 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 39 46 profiles21,22 profiles21,22 NNP 10_1101-2020_03_27_012757 39 47 . . . 10_1101-2020_03_27_012757 40 1 More more RBR 10_1101-2020_03_27_012757 40 2 recently recently RB 10_1101-2020_03_27_012757 40 3 , , , 10_1101-2020_03_27_012757 40 4 we -PRON- PRP 10_1101-2020_03_27_012757 40 5 elaborated elaborate VBD 10_1101-2020_03_27_012757 40 6 on on IN 10_1101-2020_03_27_012757 40 7 this this DT 10_1101-2020_03_27_012757 40 8 135 135 CD 10_1101-2020_03_27_012757 40 9 approach approach NN 10_1101-2020_03_27_012757 40 10 to to TO 10_1101-2020_03_27_012757 40 11 allow allow VB 10_1101-2020_03_27_012757 40 12 for for IN 10_1101-2020_03_27_012757 40 13 classification classification NN 10_1101-2020_03_27_012757 40 14 of of IN 10_1101-2020_03_27_012757 40 15 single single JJ 10_1101-2020_03_27_012757 40 16 cell cell NN 10_1101-2020_03_27_012757 40 17 RNA RNA NNP 10_1101-2020_03_27_012757 40 18 - - HYPH 10_1101-2020_03_27_012757 40 19 seq seq NN 10_1101-2020_03_27_012757 40 20 data datum NNS 10_1101-2020_03_27_012757 40 21 in in IN 10_1101-2020_03_27_012757 40 22 a a DT 10_1101-2020_03_27_012757 40 23 manner manner NN 10_1101-2020_03_27_012757 40 24 that that WDT 10_1101-2020_03_27_012757 40 25 allows allow VBZ 10_1101-2020_03_27_012757 40 26 for for IN 10_1101-2020_03_27_012757 40 27 136 136 CD 10_1101-2020_03_27_012757 40 28 cross cross JJ 10_1101-2020_03_27_012757 40 29 - - NN 10_1101-2020_03_27_012757 40 30 platform platform NN 10_1101-2020_03_27_012757 40 31 and and CC 10_1101-2020_03_27_012757 40 32 cross cross NN 10_1101-2020_03_27_012757 40 33 - - NN 10_1101-2020_03_27_012757 40 34 species species JJ 10_1101-2020_03_27_012757 40 35 analysis23 analysis23 NNS 10_1101-2020_03_27_012757 40 36 . . . 10_1101-2020_03_27_012757 41 1 Here here RB 10_1101-2020_03_27_012757 41 2 , , , 10_1101-2020_03_27_012757 41 3 we -PRON- PRP 10_1101-2020_03_27_012757 41 4 used use VBD 10_1101-2020_03_27_012757 41 5 an an DT 10_1101-2020_03_27_012757 41 6 analogous analogous JJ 10_1101-2020_03_27_012757 41 7 approach approach NN 10_1101-2020_03_27_012757 41 8 to to TO 10_1101-2020_03_27_012757 41 9 build build VB 10_1101-2020_03_27_012757 41 10 a a DT 10_1101-2020_03_27_012757 41 11 137 137 CD 10_1101-2020_03_27_012757 41 12 .CC .CC NFP 10_1101-2020_03_27_012757 41 13 - - HYPH 10_1101-2020_03_27_012757 41 14 BY by IN 10_1101-2020_03_27_012757 41 15 - - HYPH 10_1101-2020_03_27_012757 41 16 NC NC NNP 10_1101-2020_03_27_012757 41 17 - - HYPH 10_1101-2020_03_27_012757 41 18 ND ND NNP 10_1101-2020_03_27_012757 41 19 4.0 4.0 CD 10_1101-2020_03_27_012757 41 20 International International NNP 10_1101-2020_03_27_012757 41 21 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 41 22 under under IN 10_1101-2020_03_27_012757 41 23 a a DT 10_1101-2020_03_27_012757 41 24 ( ( -LRB- 10_1101-2020_03_27_012757 41 25 which which WDT 10_1101-2020_03_27_012757 41 26 was be VBD 10_1101-2020_03_27_012757 41 27 not not RB 10_1101-2020_03_27_012757 41 28 certified certify VBN 10_1101-2020_03_27_012757 41 29 by by IN 10_1101-2020_03_27_012757 41 30 peer peer NN 10_1101-2020_03_27_012757 41 31 review review NN 10_1101-2020_03_27_012757 41 32 ) ) -RRB- 10_1101-2020_03_27_012757 41 33 is be VBZ 10_1101-2020_03_27_012757 41 34 the the DT 10_1101-2020_03_27_012757 41 35 author author NN 10_1101-2020_03_27_012757 41 36 / / SYM 10_1101-2020_03_27_012757 41 37 funder funder NN 10_1101-2020_03_27_012757 41 38 , , , 10_1101-2020_03_27_012757 41 39 who who WP 10_1101-2020_03_27_012757 41 40 has have VBZ 10_1101-2020_03_27_012757 41 41 granted grant VBN 10_1101-2020_03_27_012757 41 42 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 41 43 a a DT 10_1101-2020_03_27_012757 41 44 license license NN 10_1101-2020_03_27_012757 41 45 to to TO 10_1101-2020_03_27_012757 41 46 display display VB 10_1101-2020_03_27_012757 41 47 the the DT 10_1101-2020_03_27_012757 41 48 preprint preprint NN 10_1101-2020_03_27_012757 41 49 in in IN 10_1101-2020_03_27_012757 41 50 perpetuity perpetuity NN 10_1101-2020_03_27_012757 41 51 . . . 10_1101-2020_03_27_012757 42 1 It -PRON- PRP 10_1101-2020_03_27_012757 42 2 is be VBZ 10_1101-2020_03_27_012757 42 3 made make VBN 10_1101-2020_03_27_012757 42 4 The the DT 10_1101-2020_03_27_012757 42 5 copyright copyright NN 10_1101-2020_03_27_012757 42 6 holder holder NN 10_1101-2020_03_27_012757 42 7 for for IN 10_1101-2020_03_27_012757 42 8 this this DT 10_1101-2020_03_27_012757 42 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 42 10 version version NN 10_1101-2020_03_27_012757 42 11 posted post VBD 10_1101-2020_03_27_012757 42 12 January January NNP 10_1101-2020_03_27_012757 42 13 9 9 CD 10_1101-2020_03_27_012757 42 14 , , , 10_1101-2020_03_27_012757 42 15 2021 2021 CD 10_1101-2020_03_27_012757 42 16 . . . 10_1101-2020_03_27_012757 42 17 ; ; : 10_1101-2020_03_27_012757 42 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 42 19 : : : 10_1101-2020_03_27_012757 42 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 42 21 preprint preprint NN 10_1101-2020_03_27_012757 42 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NN 10_1101-2020_03_27_012757 42 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 42 24 5 5 CD 10_1101-2020_03_27_012757 42 25 platform platform NN 10_1101-2020_03_27_012757 42 26 that that WDT 10_1101-2020_03_27_012757 42 27 would would MD 10_1101-2020_03_27_012757 42 28 allow allow VB 10_1101-2020_03_27_012757 42 29 us -PRON- PRP 10_1101-2020_03_27_012757 42 30 to to TO 10_1101-2020_03_27_012757 42 31 quantitatively quantitatively RB 10_1101-2020_03_27_012757 42 32 compare compare VB 10_1101-2020_03_27_012757 42 33 cancer cancer NN 10_1101-2020_03_27_012757 42 34 models model NNS 10_1101-2020_03_27_012757 42 35 to to IN 10_1101-2020_03_27_012757 42 36 naturally naturally RB 10_1101-2020_03_27_012757 42 37 occurring occur VBG 10_1101-2020_03_27_012757 42 38 138 138 CD 10_1101-2020_03_27_012757 42 39 patient patient JJ 10_1101-2020_03_27_012757 42 40 tumors tumor NNS 10_1101-2020_03_27_012757 42 41 ( ( -LRB- 10_1101-2020_03_27_012757 42 42 Fig fig NN 10_1101-2020_03_27_012757 42 43 1A 1A VBG 10_1101-2020_03_27_012757 42 44 ) ) -RRB- 10_1101-2020_03_27_012757 42 45 . . . 10_1101-2020_03_27_012757 43 1 In in IN 10_1101-2020_03_27_012757 43 2 brief brief NN 10_1101-2020_03_27_012757 43 3 , , , 10_1101-2020_03_27_012757 43 4 we -PRON- PRP 10_1101-2020_03_27_012757 43 5 used use VBD 10_1101-2020_03_27_012757 43 6 TCGA TCGA NNP 10_1101-2020_03_27_012757 43 7 RNA RNA NNP 10_1101-2020_03_27_012757 43 8 - - HYPH 10_1101-2020_03_27_012757 43 9 seq seq NN 10_1101-2020_03_27_012757 43 10 expression expression NN 10_1101-2020_03_27_012757 43 11 data datum NNS 10_1101-2020_03_27_012757 43 12 from from IN 10_1101-2020_03_27_012757 43 13 22 22 CD 10_1101-2020_03_27_012757 43 14 solid solid JJ 10_1101-2020_03_27_012757 43 15 tumor tumor NN 10_1101-2020_03_27_012757 43 16 139 139 CD 10_1101-2020_03_27_012757 43 17 types type NNS 10_1101-2020_03_27_012757 43 18 to to TO 10_1101-2020_03_27_012757 43 19 train train VB 10_1101-2020_03_27_012757 43 20 a a DT 10_1101-2020_03_27_012757 43 21 top top JJ 10_1101-2020_03_27_012757 43 22 - - HYPH 10_1101-2020_03_27_012757 43 23 pair pair NN 10_1101-2020_03_27_012757 43 24 multi multi JJ 10_1101-2020_03_27_012757 43 25 - - JJ 10_1101-2020_03_27_012757 43 26 class class JJ 10_1101-2020_03_27_012757 43 27 Random random JJ 10_1101-2020_03_27_012757 43 28 forest forest NN 10_1101-2020_03_27_012757 43 29 classifier classifier NN 10_1101-2020_03_27_012757 43 30 ( ( -LRB- 10_1101-2020_03_27_012757 43 31 Fig fig NN 10_1101-2020_03_27_012757 43 32 1B 1B NNP 10_1101-2020_03_27_012757 43 33 ) ) -RRB- 10_1101-2020_03_27_012757 43 34 . . . 10_1101-2020_03_27_012757 44 1 We -PRON- PRP 10_1101-2020_03_27_012757 44 2 combined combine VBD 10_1101-2020_03_27_012757 44 3 training training NN 10_1101-2020_03_27_012757 44 4 140 140 CD 10_1101-2020_03_27_012757 44 5 data datum NNS 10_1101-2020_03_27_012757 44 6 from from IN 10_1101-2020_03_27_012757 44 7 Rectal Rectal NNP 10_1101-2020_03_27_012757 44 8 Adenocarcinoma Adenocarcinoma NNP 10_1101-2020_03_27_012757 44 9 ( ( -LRB- 10_1101-2020_03_27_012757 44 10 READ READ NNP 10_1101-2020_03_27_012757 44 11 ) ) -RRB- 10_1101-2020_03_27_012757 44 12 and and CC 10_1101-2020_03_27_012757 44 13 Colon Colon NNP 10_1101-2020_03_27_012757 44 14 Adenocarcinoma Adenocarcinoma NNP 10_1101-2020_03_27_012757 44 15 ( ( -LRB- 10_1101-2020_03_27_012757 44 16 COAD COAD NNP 10_1101-2020_03_27_012757 44 17 ) ) -RRB- 10_1101-2020_03_27_012757 44 18 into into IN 10_1101-2020_03_27_012757 44 19 one one CD 10_1101-2020_03_27_012757 44 20 141 141 CD 10_1101-2020_03_27_012757 44 21 COAD_READ coad_read JJ 10_1101-2020_03_27_012757 44 22 category category NN 10_1101-2020_03_27_012757 44 23 because because IN 10_1101-2020_03_27_012757 44 24 READ READ NNP 10_1101-2020_03_27_012757 44 25 and and CC 10_1101-2020_03_27_012757 44 26 COAD COAD NNP 10_1101-2020_03_27_012757 44 27 are be VBP 10_1101-2020_03_27_012757 44 28 considered consider VBN 10_1101-2020_03_27_012757 44 29 to to TO 10_1101-2020_03_27_012757 44 30 be be VB 10_1101-2020_03_27_012757 44 31 virtually virtually RB 10_1101-2020_03_27_012757 44 32 142 142 CD 10_1101-2020_03_27_012757 44 33 indistinguishable indistinguishable JJ 10_1101-2020_03_27_012757 44 34 at at IN 10_1101-2020_03_27_012757 44 35 a a DT 10_1101-2020_03_27_012757 44 36 molecular molecular JJ 10_1101-2020_03_27_012757 44 37 level24 level24 NN 10_1101-2020_03_27_012757 44 38 . . . 10_1101-2020_03_27_012757 45 1 We -PRON- PRP 10_1101-2020_03_27_012757 45 2 included include VBD 10_1101-2020_03_27_012757 45 3 an an DT 10_1101-2020_03_27_012757 45 4 ‘ ' `` 10_1101-2020_03_27_012757 45 5 Unknown unknown JJ 10_1101-2020_03_27_012757 45 6 ’ ' '' 10_1101-2020_03_27_012757 45 7 category category NN 10_1101-2020_03_27_012757 45 8 trained train VBD 10_1101-2020_03_27_012757 45 9 using use VBG 10_1101-2020_03_27_012757 45 10 143 143 CD 10_1101-2020_03_27_012757 45 11 randomly randomly RB 10_1101-2020_03_27_012757 45 12 shuffled shuffle VBN 10_1101-2020_03_27_012757 45 13 gene gene NN 10_1101-2020_03_27_012757 45 14 - - HYPH 10_1101-2020_03_27_012757 45 15 pair pair NN 10_1101-2020_03_27_012757 45 16 profiles profile NNS 10_1101-2020_03_27_012757 45 17 generated generate VBN 10_1101-2020_03_27_012757 45 18 from from IN 10_1101-2020_03_27_012757 45 19 the the DT 10_1101-2020_03_27_012757 45 20 training training NN 10_1101-2020_03_27_012757 45 21 data datum NNS 10_1101-2020_03_27_012757 45 22 of of IN 10_1101-2020_03_27_012757 45 23 22 22 CD 10_1101-2020_03_27_012757 45 24 tumor tumor NN 10_1101-2020_03_27_012757 45 25 types type NNS 10_1101-2020_03_27_012757 45 26 to to IN 10_1101-2020_03_27_012757 45 27 144 144 CD 10_1101-2020_03_27_012757 45 28 identify identify VB 10_1101-2020_03_27_012757 45 29 query query NN 10_1101-2020_03_27_012757 45 30 samples sample NNS 10_1101-2020_03_27_012757 45 31 that that WDT 10_1101-2020_03_27_012757 45 32 are be VBP 10_1101-2020_03_27_012757 45 33 not not RB 10_1101-2020_03_27_012757 45 34 reflective reflective JJ 10_1101-2020_03_27_012757 45 35 of of IN 10_1101-2020_03_27_012757 45 36 any any DT 10_1101-2020_03_27_012757 45 37 of of IN 10_1101-2020_03_27_012757 45 38 the the DT 10_1101-2020_03_27_012757 45 39 training training NN 10_1101-2020_03_27_012757 45 40 data datum NNS 10_1101-2020_03_27_012757 45 41 . . . 10_1101-2020_03_27_012757 46 1 To to TO 10_1101-2020_03_27_012757 46 2 estimate estimate VB 10_1101-2020_03_27_012757 46 3 the the DT 10_1101-2020_03_27_012757 46 4 145 145 CD 10_1101-2020_03_27_012757 46 5 performance performance NN 10_1101-2020_03_27_012757 46 6 of of IN 10_1101-2020_03_27_012757 46 7 CCN CCN NNP 10_1101-2020_03_27_012757 46 8 and and CC 10_1101-2020_03_27_012757 46 9 how how WRB 10_1101-2020_03_27_012757 46 10 it -PRON- PRP 10_1101-2020_03_27_012757 46 11 is be VBZ 10_1101-2020_03_27_012757 46 12 impacted impact VBN 10_1101-2020_03_27_012757 46 13 by by IN 10_1101-2020_03_27_012757 46 14 parameter parameter NN 10_1101-2020_03_27_012757 46 15 variation variation NN 10_1101-2020_03_27_012757 46 16 , , , 10_1101-2020_03_27_012757 46 17 we -PRON- PRP 10_1101-2020_03_27_012757 46 18 performed perform VBD 10_1101-2020_03_27_012757 46 19 a a DT 10_1101-2020_03_27_012757 46 20 parameter parameter NN 10_1101-2020_03_27_012757 46 21 146 146 CD 10_1101-2020_03_27_012757 46 22 sweep sweep NN 10_1101-2020_03_27_012757 46 23 with with IN 10_1101-2020_03_27_012757 46 24 a a DT 10_1101-2020_03_27_012757 46 25 5-fold 5-fold CD 10_1101-2020_03_27_012757 46 26 2/3 2/3 CD 10_1101-2020_03_27_012757 46 27 cross cross NN 10_1101-2020_03_27_012757 46 28 - - JJ 10_1101-2020_03_27_012757 46 29 validation validation JJ 10_1101-2020_03_27_012757 46 30 strategy strategy NN 10_1101-2020_03_27_012757 46 31 ( ( -LRB- 10_1101-2020_03_27_012757 46 32 i.e. i.e. FW 10_1101-2020_03_27_012757 47 1 2/3 2/3 CD 10_1101-2020_03_27_012757 47 2 of of IN 10_1101-2020_03_27_012757 47 3 the the DT 10_1101-2020_03_27_012757 47 4 data datum NNS 10_1101-2020_03_27_012757 47 5 sampled sample VBN 10_1101-2020_03_27_012757 47 6 across across IN 10_1101-2020_03_27_012757 47 7 each each DT 10_1101-2020_03_27_012757 47 8 147 147 CD 10_1101-2020_03_27_012757 47 9 cancer cancer NN 10_1101-2020_03_27_012757 47 10 type type NN 10_1101-2020_03_27_012757 47 11 was be VBD 10_1101-2020_03_27_012757 47 12 used use VBN 10_1101-2020_03_27_012757 47 13 to to TO 10_1101-2020_03_27_012757 47 14 train train VB 10_1101-2020_03_27_012757 47 15 , , , 10_1101-2020_03_27_012757 47 16 1/3 1/3 CD 10_1101-2020_03_27_012757 47 17 was be VBD 10_1101-2020_03_27_012757 47 18 used use VBN 10_1101-2020_03_27_012757 47 19 to to TO 10_1101-2020_03_27_012757 47 20 validate validate VB 10_1101-2020_03_27_012757 47 21 ) ) -RRB- 10_1101-2020_03_27_012757 47 22 ( ( -LRB- 10_1101-2020_03_27_012757 47 23 Fig fig NN 10_1101-2020_03_27_012757 47 24 1C 1c NN 10_1101-2020_03_27_012757 47 25 ) ) -RRB- 10_1101-2020_03_27_012757 47 26 . . . 10_1101-2020_03_27_012757 48 1 The the DT 10_1101-2020_03_27_012757 48 2 performance performance NN 10_1101-2020_03_27_012757 48 3 of of IN 10_1101-2020_03_27_012757 48 4 CCN CCN NNP 10_1101-2020_03_27_012757 48 5 , , , 10_1101-2020_03_27_012757 48 6 as as IN 10_1101-2020_03_27_012757 48 7 148 148 CD 10_1101-2020_03_27_012757 48 8 measured measure VBN 10_1101-2020_03_27_012757 48 9 by by IN 10_1101-2020_03_27_012757 48 10 the the DT 10_1101-2020_03_27_012757 48 11 mean mean NNP 10_1101-2020_03_27_012757 48 12 area area NN 10_1101-2020_03_27_012757 48 13 under under IN 10_1101-2020_03_27_012757 48 14 the the DT 10_1101-2020_03_27_012757 48 15 precision precision NN 10_1101-2020_03_27_012757 48 16 recall recall NN 10_1101-2020_03_27_012757 48 17 curve curve NN 10_1101-2020_03_27_012757 48 18 ( ( -LRB- 10_1101-2020_03_27_012757 48 19 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 48 20 ) ) -RRB- 10_1101-2020_03_27_012757 48 21 , , , 10_1101-2020_03_27_012757 48 22 did do VBD 10_1101-2020_03_27_012757 48 23 not not RB 10_1101-2020_03_27_012757 48 24 fall fall VB 10_1101-2020_03_27_012757 48 25 below below IN 10_1101-2020_03_27_012757 48 26 0.945 0.945 CD 10_1101-2020_03_27_012757 48 27 149 149 CD 10_1101-2020_03_27_012757 48 28 and and CC 10_1101-2020_03_27_012757 48 29 remained remain VBD 10_1101-2020_03_27_012757 48 30 relatively relatively RB 10_1101-2020_03_27_012757 48 31 stable stable JJ 10_1101-2020_03_27_012757 48 32 across across IN 10_1101-2020_03_27_012757 48 33 parameter parameter NN 10_1101-2020_03_27_012757 48 34 sets set NNS 10_1101-2020_03_27_012757 48 35 ( ( -LRB- 10_1101-2020_03_27_012757 48 36 Supp Supp NNP 10_1101-2020_03_27_012757 48 37 Fig Fig NNP 10_1101-2020_03_27_012757 48 38 1A 1a NN 10_1101-2020_03_27_012757 48 39 ) ) -RRB- 10_1101-2020_03_27_012757 48 40 . . . 10_1101-2020_03_27_012757 49 1 The the DT 10_1101-2020_03_27_012757 49 2 optimal optimal JJ 10_1101-2020_03_27_012757 49 3 parameters parameter VBZ 10_1101-2020_03_27_012757 49 4 150 150 CD 10_1101-2020_03_27_012757 49 5 resulted result VBD 10_1101-2020_03_27_012757 49 6 in in IN 10_1101-2020_03_27_012757 49 7 1,979 1,979 CD 10_1101-2020_03_27_012757 49 8 features feature NNS 10_1101-2020_03_27_012757 49 9 . . . 10_1101-2020_03_27_012757 50 1 The the DT 10_1101-2020_03_27_012757 50 2 mean mean JJ 10_1101-2020_03_27_012757 50 3 AUPRCs AUPRCs NNP 10_1101-2020_03_27_012757 50 4 exceeded exceed VBD 10_1101-2020_03_27_012757 50 5 0.95 0.95 CD 10_1101-2020_03_27_012757 50 6 in in IN 10_1101-2020_03_27_012757 50 7 most most JJS 10_1101-2020_03_27_012757 50 8 tumor tumor NN 10_1101-2020_03_27_012757 50 9 types type NNS 10_1101-2020_03_27_012757 50 10 with with IN 10_1101-2020_03_27_012757 50 11 this this DT 10_1101-2020_03_27_012757 50 12 151 151 CD 10_1101-2020_03_27_012757 50 13 optimal optimal JJ 10_1101-2020_03_27_012757 50 14 parameter parameter NN 10_1101-2020_03_27_012757 50 15 set set NN 10_1101-2020_03_27_012757 50 16 ( ( -LRB- 10_1101-2020_03_27_012757 50 17 Fig fig NN 10_1101-2020_03_27_012757 50 18 1D 1d NN 10_1101-2020_03_27_012757 50 19 , , , 10_1101-2020_03_27_012757 50 20 Supp Supp NNP 10_1101-2020_03_27_012757 50 21 Fig Fig NNP 10_1101-2020_03_27_012757 50 22 1B 1b NN 10_1101-2020_03_27_012757 50 23 ) ) -RRB- 10_1101-2020_03_27_012757 50 24 . . . 10_1101-2020_03_27_012757 51 1 The the DT 10_1101-2020_03_27_012757 51 2 AUPRCs auprc NNS 10_1101-2020_03_27_012757 51 3 of of IN 10_1101-2020_03_27_012757 51 4 CCN CCN NNP 10_1101-2020_03_27_012757 51 5 applied apply VBN 10_1101-2020_03_27_012757 51 6 to to IN 10_1101-2020_03_27_012757 51 7 independent independent JJ 10_1101-2020_03_27_012757 51 8 152 152 CD 10_1101-2020_03_27_012757 51 9 data datum NNS 10_1101-2020_03_27_012757 51 10 RNA RNA NNP 10_1101-2020_03_27_012757 51 11 - - HYPH 10_1101-2020_03_27_012757 51 12 Seq Seq NNP 10_1101-2020_03_27_012757 51 13 data datum NNS 10_1101-2020_03_27_012757 51 14 from from IN 10_1101-2020_03_27_012757 51 15 725 725 CD 10_1101-2020_03_27_012757 51 16 tumors tumor NNS 10_1101-2020_03_27_012757 51 17 across across IN 10_1101-2020_03_27_012757 51 18 five five CD 10_1101-2020_03_27_012757 51 19 tumor tumor NN 10_1101-2020_03_27_012757 51 20 types type NNS 10_1101-2020_03_27_012757 51 21 from from IN 10_1101-2020_03_27_012757 51 22 the the DT 10_1101-2020_03_27_012757 51 23 International International NNP 10_1101-2020_03_27_012757 51 24 Cancer Cancer NNP 10_1101-2020_03_27_012757 51 25 153 153 CD 10_1101-2020_03_27_012757 51 26 Genome Genome NNP 10_1101-2020_03_27_012757 51 27 Consortium Consortium NNP 10_1101-2020_03_27_012757 51 28 ( ( -LRB- 10_1101-2020_03_27_012757 51 29 ICGC)25 ICGC)25 NNP 10_1101-2020_03_27_012757 51 30 ranged range VBD 10_1101-2020_03_27_012757 51 31 from from IN 10_1101-2020_03_27_012757 51 32 0.93 0.93 CD 10_1101-2020_03_27_012757 51 33 to to IN 10_1101-2020_03_27_012757 51 34 0.99 0.99 CD 10_1101-2020_03_27_012757 51 35 , , , 10_1101-2020_03_27_012757 51 36 supporting support VBG 10_1101-2020_03_27_012757 51 37 the the DT 10_1101-2020_03_27_012757 51 38 notion notion NN 10_1101-2020_03_27_012757 51 39 that that IN 10_1101-2020_03_27_012757 51 40 the the DT 10_1101-2020_03_27_012757 51 41 platform platform NN 10_1101-2020_03_27_012757 51 42 154 154 CD 10_1101-2020_03_27_012757 51 43 is be VBZ 10_1101-2020_03_27_012757 51 44 able able JJ 10_1101-2020_03_27_012757 51 45 to to TO 10_1101-2020_03_27_012757 51 46 accurately accurately RB 10_1101-2020_03_27_012757 51 47 classify classify VB 10_1101-2020_03_27_012757 51 48 tumor tumor NN 10_1101-2020_03_27_012757 51 49 samples sample NNS 10_1101-2020_03_27_012757 51 50 from from IN 10_1101-2020_03_27_012757 51 51 diverse diverse JJ 10_1101-2020_03_27_012757 51 52 sources source NNS 10_1101-2020_03_27_012757 51 53 ( ( -LRB- 10_1101-2020_03_27_012757 51 54 Fig fig NN 10_1101-2020_03_27_012757 51 55 1E 1E NNP 10_1101-2020_03_27_012757 51 56 ) ) -RRB- 10_1101-2020_03_27_012757 51 57 . . . 10_1101-2020_03_27_012757 52 1 155 155 CD 10_1101-2020_03_27_012757 52 2 As as IN 10_1101-2020_03_27_012757 52 3 one one CD 10_1101-2020_03_27_012757 52 4 of of IN 10_1101-2020_03_27_012757 52 5 the the DT 10_1101-2020_03_27_012757 52 6 central central JJ 10_1101-2020_03_27_012757 52 7 aims aim NNS 10_1101-2020_03_27_012757 52 8 of of IN 10_1101-2020_03_27_012757 52 9 our -PRON- PRP$ 10_1101-2020_03_27_012757 52 10 study study NN 10_1101-2020_03_27_012757 52 11 is be VBZ 10_1101-2020_03_27_012757 52 12 to to TO 10_1101-2020_03_27_012757 52 13 compare compare VB 10_1101-2020_03_27_012757 52 14 distinct distinct JJ 10_1101-2020_03_27_012757 52 15 cancer cancer NN 10_1101-2020_03_27_012757 52 16 models model NNS 10_1101-2020_03_27_012757 52 17 , , , 10_1101-2020_03_27_012757 52 18 including include VBG 10_1101-2020_03_27_012757 52 19 156 156 CD 10_1101-2020_03_27_012757 52 20 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 52 21 , , , 10_1101-2020_03_27_012757 52 22 our -PRON- PRP$ 10_1101-2020_03_27_012757 52 23 method method NN 10_1101-2020_03_27_012757 52 24 needed need VBD 10_1101-2020_03_27_012757 52 25 to to TO 10_1101-2020_03_27_012757 52 26 be be VB 10_1101-2020_03_27_012757 52 27 able able JJ 10_1101-2020_03_27_012757 52 28 to to TO 10_1101-2020_03_27_012757 52 29 classify classify VB 10_1101-2020_03_27_012757 52 30 samples sample NNS 10_1101-2020_03_27_012757 52 31 from from IN 10_1101-2020_03_27_012757 52 32 mouse mouse NN 10_1101-2020_03_27_012757 52 33 and and CC 10_1101-2020_03_27_012757 52 34 human human JJ 10_1101-2020_03_27_012757 52 35 samples sample NNS 10_1101-2020_03_27_012757 52 36 157 157 CD 10_1101-2020_03_27_012757 52 37 equivalently equivalently RB 10_1101-2020_03_27_012757 52 38 . . . 10_1101-2020_03_27_012757 53 1 We -PRON- PRP 10_1101-2020_03_27_012757 53 2 used use VBD 10_1101-2020_03_27_012757 53 3 the the DT 10_1101-2020_03_27_012757 53 4 Top Top NNP 10_1101-2020_03_27_012757 53 5 - - HYPH 10_1101-2020_03_27_012757 53 6 Pair Pair NNP 10_1101-2020_03_27_012757 53 7 transform23 transform23 NNP 10_1101-2020_03_27_012757 53 8 to to TO 10_1101-2020_03_27_012757 53 9 achieve achieve VB 10_1101-2020_03_27_012757 53 10 this this DT 10_1101-2020_03_27_012757 53 11 and and CC 10_1101-2020_03_27_012757 53 12 we -PRON- PRP 10_1101-2020_03_27_012757 53 13 tested test VBD 10_1101-2020_03_27_012757 53 14 the the DT 10_1101-2020_03_27_012757 53 15 feasibility feasibility NN 10_1101-2020_03_27_012757 53 16 of of IN 10_1101-2020_03_27_012757 53 17 158 158 CD 10_1101-2020_03_27_012757 53 18 this this DT 10_1101-2020_03_27_012757 53 19 approach approach NN 10_1101-2020_03_27_012757 53 20 by by IN 10_1101-2020_03_27_012757 53 21 assessing assess VBG 10_1101-2020_03_27_012757 53 22 the the DT 10_1101-2020_03_27_012757 53 23 performance performance NN 10_1101-2020_03_27_012757 53 24 of of IN 10_1101-2020_03_27_012757 53 25 a a DT 10_1101-2020_03_27_012757 53 26 normal normal JJ 10_1101-2020_03_27_012757 53 27 ( ( -LRB- 10_1101-2020_03_27_012757 53 28 i.e. i.e. FW 10_1101-2020_03_27_012757 54 1 non non JJ 10_1101-2020_03_27_012757 54 2 - - JJ 10_1101-2020_03_27_012757 54 3 tumor tumor JJ 10_1101-2020_03_27_012757 54 4 ) ) -RRB- 10_1101-2020_03_27_012757 54 5 cell cell NN 10_1101-2020_03_27_012757 54 6 and and CC 10_1101-2020_03_27_012757 54 7 tissue tissue NN 10_1101-2020_03_27_012757 54 8 159 159 CD 10_1101-2020_03_27_012757 54 9 classifier classifier NN 10_1101-2020_03_27_012757 54 10 trained train VBN 10_1101-2020_03_27_012757 54 11 on on IN 10_1101-2020_03_27_012757 54 12 human human JJ 10_1101-2020_03_27_012757 54 13 data datum NNS 10_1101-2020_03_27_012757 54 14 as as IN 10_1101-2020_03_27_012757 54 15 applied apply VBN 10_1101-2020_03_27_012757 54 16 to to IN 10_1101-2020_03_27_012757 54 17 mouse mouse NN 10_1101-2020_03_27_012757 54 18 samples sample NNS 10_1101-2020_03_27_012757 54 19 . . . 10_1101-2020_03_27_012757 55 1 Consistent consistent JJ 10_1101-2020_03_27_012757 55 2 with with IN 10_1101-2020_03_27_012757 55 3 prior prior JJ 10_1101-2020_03_27_012757 55 4 160 160 CD 10_1101-2020_03_27_012757 55 5 applications23 applications23 NNS 10_1101-2020_03_27_012757 55 6 , , , 10_1101-2020_03_27_012757 55 7 we -PRON- PRP 10_1101-2020_03_27_012757 55 8 found find VBD 10_1101-2020_03_27_012757 55 9 that that IN 10_1101-2020_03_27_012757 55 10 the the DT 10_1101-2020_03_27_012757 55 11 cross cross JJ 10_1101-2020_03_27_012757 55 12 - - JJ 10_1101-2020_03_27_012757 55 13 species species JJ 10_1101-2020_03_27_012757 55 14 classifier classifier NN 10_1101-2020_03_27_012757 55 15 performed perform VBD 10_1101-2020_03_27_012757 55 16 well well RB 10_1101-2020_03_27_012757 55 17 , , , 10_1101-2020_03_27_012757 55 18 achieving achieve VBG 10_1101-2020_03_27_012757 55 19 mean mean VB 10_1101-2020_03_27_012757 55 20 161 161 CD 10_1101-2020_03_27_012757 55 21 AUPRC AUPRC NNS 10_1101-2020_03_27_012757 55 22 of of IN 10_1101-2020_03_27_012757 55 23 0.97 0.97 CD 10_1101-2020_03_27_012757 55 24 when when WRB 10_1101-2020_03_27_012757 55 25 applied apply VBN 10_1101-2020_03_27_012757 55 26 to to IN 10_1101-2020_03_27_012757 55 27 mouse mouse NN 10_1101-2020_03_27_012757 55 28 data datum NNS 10_1101-2020_03_27_012757 55 29 ( ( -LRB- 10_1101-2020_03_27_012757 55 30 Supp Supp NNP 10_1101-2020_03_27_012757 55 31 Fig Fig NNP 10_1101-2020_03_27_012757 55 32 1C 1c NN 10_1101-2020_03_27_012757 55 33 ) ) -RRB- 10_1101-2020_03_27_012757 55 34 . . . 10_1101-2020_03_27_012757 56 1 162 162 CD 10_1101-2020_03_27_012757 56 2 .CC .CC : 10_1101-2020_03_27_012757 56 3 - - HYPH 10_1101-2020_03_27_012757 56 4 BY by IN 10_1101-2020_03_27_012757 56 5 - - HYPH 10_1101-2020_03_27_012757 56 6 NC NC NNP 10_1101-2020_03_27_012757 56 7 - - HYPH 10_1101-2020_03_27_012757 56 8 ND ND NNP 10_1101-2020_03_27_012757 56 9 4.0 4.0 CD 10_1101-2020_03_27_012757 56 10 International International NNP 10_1101-2020_03_27_012757 56 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 56 12 under under IN 10_1101-2020_03_27_012757 56 13 a a DT 10_1101-2020_03_27_012757 56 14 ( ( -LRB- 10_1101-2020_03_27_012757 56 15 which which WDT 10_1101-2020_03_27_012757 56 16 was be VBD 10_1101-2020_03_27_012757 56 17 not not RB 10_1101-2020_03_27_012757 56 18 certified certify VBN 10_1101-2020_03_27_012757 56 19 by by IN 10_1101-2020_03_27_012757 56 20 peer peer NN 10_1101-2020_03_27_012757 56 21 review review NN 10_1101-2020_03_27_012757 56 22 ) ) -RRB- 10_1101-2020_03_27_012757 56 23 is be VBZ 10_1101-2020_03_27_012757 56 24 the the DT 10_1101-2020_03_27_012757 56 25 author author NN 10_1101-2020_03_27_012757 56 26 / / SYM 10_1101-2020_03_27_012757 56 27 funder funder NN 10_1101-2020_03_27_012757 56 28 , , , 10_1101-2020_03_27_012757 56 29 who who WP 10_1101-2020_03_27_012757 56 30 has have VBZ 10_1101-2020_03_27_012757 56 31 granted grant VBN 10_1101-2020_03_27_012757 56 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 56 33 a a DT 10_1101-2020_03_27_012757 56 34 license license NN 10_1101-2020_03_27_012757 56 35 to to TO 10_1101-2020_03_27_012757 56 36 display display VB 10_1101-2020_03_27_012757 56 37 the the DT 10_1101-2020_03_27_012757 56 38 preprint preprint NN 10_1101-2020_03_27_012757 56 39 in in IN 10_1101-2020_03_27_012757 56 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 56 41 . . . 10_1101-2020_03_27_012757 57 1 It -PRON- PRP 10_1101-2020_03_27_012757 57 2 is be VBZ 10_1101-2020_03_27_012757 57 3 made make VBN 10_1101-2020_03_27_012757 57 4 The the DT 10_1101-2020_03_27_012757 57 5 copyright copyright NN 10_1101-2020_03_27_012757 57 6 holder holder NN 10_1101-2020_03_27_012757 57 7 for for IN 10_1101-2020_03_27_012757 57 8 this this DT 10_1101-2020_03_27_012757 57 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 57 10 version version NN 10_1101-2020_03_27_012757 57 11 posted post VBD 10_1101-2020_03_27_012757 57 12 January January NNP 10_1101-2020_03_27_012757 57 13 9 9 CD 10_1101-2020_03_27_012757 57 14 , , , 10_1101-2020_03_27_012757 57 15 2021 2021 CD 10_1101-2020_03_27_012757 57 16 . . . 10_1101-2020_03_27_012757 57 17 ; ; : 10_1101-2020_03_27_012757 57 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 57 19 : : : 10_1101-2020_03_27_012757 57 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 57 21 preprint preprint NN 10_1101-2020_03_27_012757 57 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 57 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 57 24 6 6 CD 10_1101-2020_03_27_012757 57 25 To to TO 10_1101-2020_03_27_012757 57 26 evaluate evaluate VB 10_1101-2020_03_27_012757 57 27 cancer cancer NN 10_1101-2020_03_27_012757 57 28 models model NNS 10_1101-2020_03_27_012757 57 29 at at IN 10_1101-2020_03_27_012757 57 30 a a DT 10_1101-2020_03_27_012757 57 31 finer fine JJR 10_1101-2020_03_27_012757 57 32 resolution resolution NN 10_1101-2020_03_27_012757 57 33 , , , 10_1101-2020_03_27_012757 57 34 we -PRON- PRP 10_1101-2020_03_27_012757 57 35 also also RB 10_1101-2020_03_27_012757 57 36 developed develop VBD 10_1101-2020_03_27_012757 57 37 an an DT 10_1101-2020_03_27_012757 57 38 approach approach NN 10_1101-2020_03_27_012757 57 39 to to IN 10_1101-2020_03_27_012757 57 40 163 163 CD 10_1101-2020_03_27_012757 57 41 perform perform VB 10_1101-2020_03_27_012757 57 42 tumor tumor NN 10_1101-2020_03_27_012757 57 43 subtype subtype NN 10_1101-2020_03_27_012757 57 44 classifications classification NNS 10_1101-2020_03_27_012757 57 45 ( ( -LRB- 10_1101-2020_03_27_012757 57 46 Supp Supp NNP 10_1101-2020_03_27_012757 57 47 Fig Fig NNP 10_1101-2020_03_27_012757 57 48 1D 1d NN 10_1101-2020_03_27_012757 57 49 ) ) -RRB- 10_1101-2020_03_27_012757 57 50 . . . 10_1101-2020_03_27_012757 58 1 We -PRON- PRP 10_1101-2020_03_27_012757 58 2 constructed construct VBD 10_1101-2020_03_27_012757 58 3 11 11 CD 10_1101-2020_03_27_012757 58 4 different different JJ 10_1101-2020_03_27_012757 58 5 cancer cancer NN 10_1101-2020_03_27_012757 58 6 164 164 CD 10_1101-2020_03_27_012757 58 7 subtype subtype NN 10_1101-2020_03_27_012757 58 8 classifiers classifier NNS 10_1101-2020_03_27_012757 58 9 based base VBN 10_1101-2020_03_27_012757 58 10 on on IN 10_1101-2020_03_27_012757 58 11 the the DT 10_1101-2020_03_27_012757 58 12 availability availability NN 10_1101-2020_03_27_012757 58 13 of of IN 10_1101-2020_03_27_012757 58 14 expression expression NN 10_1101-2020_03_27_012757 58 15 or or CC 10_1101-2020_03_27_012757 58 16 histological histological JJ 10_1101-2020_03_27_012757 58 17 subtype subtype NN 10_1101-2020_03_27_012757 58 18 165 165 CD 10_1101-2020_03_27_012757 58 19 information24,26–36 information24,26–36 NNP 10_1101-2020_03_27_012757 58 20 . . . 10_1101-2020_03_27_012757 59 1 We -PRON- PRP 10_1101-2020_03_27_012757 59 2 also also RB 10_1101-2020_03_27_012757 59 3 included include VBD 10_1101-2020_03_27_012757 59 4 non non JJ 10_1101-2020_03_27_012757 59 5 - - JJ 10_1101-2020_03_27_012757 59 6 cancerous cancerous JJ 10_1101-2020_03_27_012757 59 7 , , , 10_1101-2020_03_27_012757 59 8 normal normal JJ 10_1101-2020_03_27_012757 59 9 tissues tissue NNS 10_1101-2020_03_27_012757 59 10 as as IN 10_1101-2020_03_27_012757 59 11 categories category NNS 10_1101-2020_03_27_012757 59 12 for for IN 10_1101-2020_03_27_012757 59 13 several several JJ 10_1101-2020_03_27_012757 59 14 166 166 CD 10_1101-2020_03_27_012757 59 15 subtype subtype NN 10_1101-2020_03_27_012757 59 16 classifiers classifier NNS 10_1101-2020_03_27_012757 59 17 when when WRB 10_1101-2020_03_27_012757 59 18 sufficient sufficient JJ 10_1101-2020_03_27_012757 59 19 data datum NNS 10_1101-2020_03_27_012757 59 20 was be VBD 10_1101-2020_03_27_012757 59 21 available available JJ 10_1101-2020_03_27_012757 59 22 : : : 10_1101-2020_03_27_012757 59 23 breast breast NN 10_1101-2020_03_27_012757 59 24 invasive invasive JJ 10_1101-2020_03_27_012757 59 25 carcinoma carcinoma NN 10_1101-2020_03_27_012757 59 26 ( ( -LRB- 10_1101-2020_03_27_012757 59 27 BRCA BRCA NNP 10_1101-2020_03_27_012757 59 28 ) ) -RRB- 10_1101-2020_03_27_012757 59 29 , , , 10_1101-2020_03_27_012757 59 30 167 167 CD 10_1101-2020_03_27_012757 59 31 COAD_READ COAD_READ NNS 10_1101-2020_03_27_012757 59 32 , , , 10_1101-2020_03_27_012757 59 33 head head NN 10_1101-2020_03_27_012757 59 34 and and CC 10_1101-2020_03_27_012757 59 35 neck neck NN 10_1101-2020_03_27_012757 59 36 squamous squamous JJ 10_1101-2020_03_27_012757 59 37 cell cell NN 10_1101-2020_03_27_012757 59 38 carcinoma carcinoma NN 10_1101-2020_03_27_012757 59 39 ( ( -LRB- 10_1101-2020_03_27_012757 59 40 HNSC HNSC NNP 10_1101-2020_03_27_012757 59 41 ) ) -RRB- 10_1101-2020_03_27_012757 59 42 , , , 10_1101-2020_03_27_012757 59 43 kidney kidney NN 10_1101-2020_03_27_012757 59 44 renal renal JJ 10_1101-2020_03_27_012757 59 45 clear clear JJ 10_1101-2020_03_27_012757 59 46 cell cell NN 10_1101-2020_03_27_012757 59 47 168 168 CD 10_1101-2020_03_27_012757 59 48 carcinoma carcinoma NN 10_1101-2020_03_27_012757 59 49 ( ( -LRB- 10_1101-2020_03_27_012757 59 50 KIRC KIRC NNP 10_1101-2020_03_27_012757 59 51 ) ) -RRB- 10_1101-2020_03_27_012757 59 52 and and CC 10_1101-2020_03_27_012757 59 53 uterine uterine NNP 10_1101-2020_03_27_012757 59 54 corpus corpus NNP 10_1101-2020_03_27_012757 59 55 endometrial endometrial JJ 10_1101-2020_03_27_012757 59 56 carcinoma carcinoma NN 10_1101-2020_03_27_012757 59 57 ( ( -LRB- 10_1101-2020_03_27_012757 59 58 UCEC UCEC NNP 10_1101-2020_03_27_012757 59 59 ) ) -RRB- 10_1101-2020_03_27_012757 59 60 . . . 10_1101-2020_03_27_012757 60 1 The the DT 10_1101-2020_03_27_012757 60 2 11 11 CD 10_1101-2020_03_27_012757 60 3 subtype subtype NN 10_1101-2020_03_27_012757 60 4 169 169 CD 10_1101-2020_03_27_012757 60 5 classifiers classifier NNS 10_1101-2020_03_27_012757 60 6 all all DT 10_1101-2020_03_27_012757 60 7 achieved achieve VBN 10_1101-2020_03_27_012757 60 8 high high JJ 10_1101-2020_03_27_012757 60 9 overall overall JJ 10_1101-2020_03_27_012757 60 10 average average JJ 10_1101-2020_03_27_012757 60 11 AUPRs aupr NNS 10_1101-2020_03_27_012757 60 12 ranging range VBG 10_1101-2020_03_27_012757 60 13 from from IN 10_1101-2020_03_27_012757 60 14 0.80 0.80 CD 10_1101-2020_03_27_012757 60 15 to to IN 10_1101-2020_03_27_012757 60 16 0.99 0.99 CD 10_1101-2020_03_27_012757 60 17 ( ( -LRB- 10_1101-2020_03_27_012757 60 18 Supp Supp NNP 10_1101-2020_03_27_012757 60 19 Fig Fig NNP 10_1101-2020_03_27_012757 60 20 1E 1e NN 10_1101-2020_03_27_012757 60 21 ) ) -RRB- 10_1101-2020_03_27_012757 60 22 . . . 10_1101-2020_03_27_012757 61 1 170 170 CD 10_1101-2020_03_27_012757 61 2 171 171 CD 10_1101-2020_03_27_012757 61 3 Fidelity Fidelity NNP 10_1101-2020_03_27_012757 61 4 of of IN 10_1101-2020_03_27_012757 61 5 cancer cancer NN 10_1101-2020_03_27_012757 61 6 cell cell NN 10_1101-2020_03_27_012757 61 7 lines line NNS 10_1101-2020_03_27_012757 61 8 172 172 CD 10_1101-2020_03_27_012757 61 9 Having have VBG 10_1101-2020_03_27_012757 61 10 validated validate VBD 10_1101-2020_03_27_012757 61 11 the the DT 10_1101-2020_03_27_012757 61 12 performance performance NN 10_1101-2020_03_27_012757 61 13 of of IN 10_1101-2020_03_27_012757 61 14 CCN CCN NNP 10_1101-2020_03_27_012757 61 15 , , , 10_1101-2020_03_27_012757 61 16 we -PRON- PRP 10_1101-2020_03_27_012757 61 17 then then RB 10_1101-2020_03_27_012757 61 18 used use VBD 10_1101-2020_03_27_012757 61 19 it -PRON- PRP 10_1101-2020_03_27_012757 61 20 to to TO 10_1101-2020_03_27_012757 61 21 determine determine VB 10_1101-2020_03_27_012757 61 22 the the DT 10_1101-2020_03_27_012757 61 23 fidelity fidelity NN 10_1101-2020_03_27_012757 61 24 of of IN 10_1101-2020_03_27_012757 61 25 173 173 CD 10_1101-2020_03_27_012757 61 26 CCLs CCLs NNPS 10_1101-2020_03_27_012757 61 27 . . . 10_1101-2020_03_27_012757 62 1 We -PRON- PRP 10_1101-2020_03_27_012757 62 2 mined mine VBD 10_1101-2020_03_27_012757 62 3 RNA RNA NNP 10_1101-2020_03_27_012757 62 4 - - HYPH 10_1101-2020_03_27_012757 62 5 seq seq NN 10_1101-2020_03_27_012757 62 6 expression expression NN 10_1101-2020_03_27_012757 62 7 data datum NNS 10_1101-2020_03_27_012757 62 8 of of IN 10_1101-2020_03_27_012757 62 9 657 657 CD 10_1101-2020_03_27_012757 62 10 different different JJ 10_1101-2020_03_27_012757 62 11 cell cell NN 10_1101-2020_03_27_012757 62 12 lines line NNS 10_1101-2020_03_27_012757 62 13 across across IN 10_1101-2020_03_27_012757 62 14 20 20 CD 10_1101-2020_03_27_012757 62 15 cancer cancer NN 10_1101-2020_03_27_012757 62 16 types type NNS 10_1101-2020_03_27_012757 62 17 174 174 CD 10_1101-2020_03_27_012757 62 18 from from IN 10_1101-2020_03_27_012757 62 19 the the DT 10_1101-2020_03_27_012757 62 20 Cancer Cancer NNP 10_1101-2020_03_27_012757 62 21 Cell Cell NNP 10_1101-2020_03_27_012757 62 22 Line Line NNP 10_1101-2020_03_27_012757 62 23 Encyclopedia Encyclopedia NNP 10_1101-2020_03_27_012757 62 24 ( ( -LRB- 10_1101-2020_03_27_012757 62 25 CCLE CCLE NNP 10_1101-2020_03_27_012757 62 26 ) ) -RRB- 10_1101-2020_03_27_012757 62 27 and and CC 10_1101-2020_03_27_012757 62 28 applied apply VBD 10_1101-2020_03_27_012757 62 29 CCN CCN NNP 10_1101-2020_03_27_012757 62 30 to to IN 10_1101-2020_03_27_012757 62 31 them -PRON- PRP 10_1101-2020_03_27_012757 62 32 , , , 10_1101-2020_03_27_012757 62 33 finding find VBG 10_1101-2020_03_27_012757 62 34 a a DT 10_1101-2020_03_27_012757 62 35 wide wide JJ 10_1101-2020_03_27_012757 62 36 175 175 CD 10_1101-2020_03_27_012757 62 37 classification classification NN 10_1101-2020_03_27_012757 62 38 range range NN 10_1101-2020_03_27_012757 62 39 for for IN 10_1101-2020_03_27_012757 62 40 cell cell NN 10_1101-2020_03_27_012757 62 41 lines line NNS 10_1101-2020_03_27_012757 62 42 of of IN 10_1101-2020_03_27_012757 62 43 each each DT 10_1101-2020_03_27_012757 62 44 tumor tumor NN 10_1101-2020_03_27_012757 62 45 type type NN 10_1101-2020_03_27_012757 62 46 ( ( -LRB- 10_1101-2020_03_27_012757 62 47 Fig fig NN 10_1101-2020_03_27_012757 62 48 2A 2a NN 10_1101-2020_03_27_012757 62 49 , , , 10_1101-2020_03_27_012757 62 50 Supp Supp NNP 10_1101-2020_03_27_012757 62 51 Tab Tab NNP 10_1101-2020_03_27_012757 62 52 1 1 CD 10_1101-2020_03_27_012757 62 53 ) ) -RRB- 10_1101-2020_03_27_012757 62 54 . . . 10_1101-2020_03_27_012757 63 1 To to TO 10_1101-2020_03_27_012757 63 2 verify verify VB 10_1101-2020_03_27_012757 63 3 the the DT 10_1101-2020_03_27_012757 63 4 176 176 CD 10_1101-2020_03_27_012757 63 5 classification classification NN 10_1101-2020_03_27_012757 63 6 results result NNS 10_1101-2020_03_27_012757 63 7 , , , 10_1101-2020_03_27_012757 63 8 we -PRON- PRP 10_1101-2020_03_27_012757 63 9 applied apply VBD 10_1101-2020_03_27_012757 63 10 CCN CCN NNP 10_1101-2020_03_27_012757 63 11 to to IN 10_1101-2020_03_27_012757 63 12 expression expression NN 10_1101-2020_03_27_012757 63 13 profiles profile NNS 10_1101-2020_03_27_012757 63 14 from from IN 10_1101-2020_03_27_012757 63 15 CCLE CCLE NNP 10_1101-2020_03_27_012757 63 16 generated generate VBN 10_1101-2020_03_27_012757 63 17 through through IN 10_1101-2020_03_27_012757 63 18 177 177 CD 10_1101-2020_03_27_012757 63 19 microarray microarray JJ 10_1101-2020_03_27_012757 63 20 expression expression NN 10_1101-2020_03_27_012757 63 21 profiling37 profiling37 NN 10_1101-2020_03_27_012757 63 22 . . . 10_1101-2020_03_27_012757 64 1 To to TO 10_1101-2020_03_27_012757 64 2 ensure ensure VB 10_1101-2020_03_27_012757 64 3 that that IN 10_1101-2020_03_27_012757 64 4 CCN CCN NNP 10_1101-2020_03_27_012757 64 5 would would MD 10_1101-2020_03_27_012757 64 6 function function VB 10_1101-2020_03_27_012757 64 7 on on IN 10_1101-2020_03_27_012757 64 8 microarray microarray JJ 10_1101-2020_03_27_012757 64 9 data datum NNS 10_1101-2020_03_27_012757 64 10 , , , 10_1101-2020_03_27_012757 64 11 we -PRON- PRP 10_1101-2020_03_27_012757 64 12 178 178 CD 10_1101-2020_03_27_012757 64 13 first first RB 10_1101-2020_03_27_012757 64 14 tested test VBD 10_1101-2020_03_27_012757 64 15 it -PRON- PRP 10_1101-2020_03_27_012757 64 16 by by IN 10_1101-2020_03_27_012757 64 17 applying apply VBG 10_1101-2020_03_27_012757 64 18 a a DT 10_1101-2020_03_27_012757 64 19 CCN CCN NNP 10_1101-2020_03_27_012757 64 20 classifier classifier NN 10_1101-2020_03_27_012757 64 21 created create VBN 10_1101-2020_03_27_012757 64 22 to to TO 10_1101-2020_03_27_012757 64 23 test test VB 10_1101-2020_03_27_012757 64 24 microarray microarray JJ 10_1101-2020_03_27_012757 64 25 data datum NNS 10_1101-2020_03_27_012757 64 26 to to IN 10_1101-2020_03_27_012757 64 27 720 720 CD 10_1101-2020_03_27_012757 64 28 expression expression NN 10_1101-2020_03_27_012757 64 29 179 179 CD 10_1101-2020_03_27_012757 64 30 profiles profile NNS 10_1101-2020_03_27_012757 64 31 of of IN 10_1101-2020_03_27_012757 64 32 12 12 CD 10_1101-2020_03_27_012757 64 33 tumor tumor NN 10_1101-2020_03_27_012757 64 34 types type NNS 10_1101-2020_03_27_012757 64 35 . . . 10_1101-2020_03_27_012757 65 1 The the DT 10_1101-2020_03_27_012757 65 2 cross cross JJ 10_1101-2020_03_27_012757 65 3 - - JJ 10_1101-2020_03_27_012757 65 4 platform platform JJ 10_1101-2020_03_27_012757 65 5 CCN CCN NNP 10_1101-2020_03_27_012757 65 6 classifier classifier NN 10_1101-2020_03_27_012757 65 7 performed perform VBD 10_1101-2020_03_27_012757 65 8 well well RB 10_1101-2020_03_27_012757 65 9 , , , 10_1101-2020_03_27_012757 65 10 based base VBN 10_1101-2020_03_27_012757 65 11 on on IN 10_1101-2020_03_27_012757 65 12 the the DT 10_1101-2020_03_27_012757 65 13 180 180 CD 10_1101-2020_03_27_012757 65 14 comparison comparison NN 10_1101-2020_03_27_012757 65 15 to to TO 10_1101-2020_03_27_012757 65 16 study study VB 10_1101-2020_03_27_012757 65 17 - - HYPH 10_1101-2020_03_27_012757 65 18 provided provide VBN 10_1101-2020_03_27_012757 65 19 annotation annotation NN 10_1101-2020_03_27_012757 65 20 , , , 10_1101-2020_03_27_012757 65 21 achieving achieve VBG 10_1101-2020_03_27_012757 65 22 a a DT 10_1101-2020_03_27_012757 65 23 mean mean JJ 10_1101-2020_03_27_012757 65 24 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 65 25 of of IN 10_1101-2020_03_27_012757 65 26 0.91 0.91 CD 10_1101-2020_03_27_012757 65 27 ( ( -LRB- 10_1101-2020_03_27_012757 65 28 Supp Supp NNP 10_1101-2020_03_27_012757 65 29 Fig Fig NNP 10_1101-2020_03_27_012757 65 30 2A 2a NN 10_1101-2020_03_27_012757 65 31 ) ) -RRB- 10_1101-2020_03_27_012757 65 32 . . . 10_1101-2020_03_27_012757 66 1 181 181 CD 10_1101-2020_03_27_012757 66 2 Next next JJ 10_1101-2020_03_27_012757 66 3 , , , 10_1101-2020_03_27_012757 66 4 we -PRON- PRP 10_1101-2020_03_27_012757 66 5 applied apply VBD 10_1101-2020_03_27_012757 66 6 this this DT 10_1101-2020_03_27_012757 66 7 cross cross JJ 10_1101-2020_03_27_012757 66 8 - - JJ 10_1101-2020_03_27_012757 66 9 platform platform JJ 10_1101-2020_03_27_012757 66 10 classifier classifier NN 10_1101-2020_03_27_012757 66 11 to to IN 10_1101-2020_03_27_012757 66 12 microarray microarray JJ 10_1101-2020_03_27_012757 66 13 expression expression NN 10_1101-2020_03_27_012757 66 14 profiles profile NNS 10_1101-2020_03_27_012757 66 15 from from IN 10_1101-2020_03_27_012757 66 16 CCLE ccle JJ 10_1101-2020_03_27_012757 66 17 182 182 CD 10_1101-2020_03_27_012757 66 18 ( ( -LRB- 10_1101-2020_03_27_012757 66 19 Supp Supp NNP 10_1101-2020_03_27_012757 66 20 Fig Fig NNP 10_1101-2020_03_27_012757 66 21 2B 2B NNS 10_1101-2020_03_27_012757 66 22 ) ) -RRB- 10_1101-2020_03_27_012757 66 23 . . . 10_1101-2020_03_27_012757 67 1 From from IN 10_1101-2020_03_27_012757 67 2 the the DT 10_1101-2020_03_27_012757 67 3 classification classification NN 10_1101-2020_03_27_012757 67 4 results result NNS 10_1101-2020_03_27_012757 67 5 of of IN 10_1101-2020_03_27_012757 67 6 571 571 CD 10_1101-2020_03_27_012757 67 7 cell cell NN 10_1101-2020_03_27_012757 67 8 lines line NNS 10_1101-2020_03_27_012757 67 9 that that WDT 10_1101-2020_03_27_012757 67 10 have have VBP 10_1101-2020_03_27_012757 67 11 both both DT 10_1101-2020_03_27_012757 67 12 RNA RNA NNP 10_1101-2020_03_27_012757 67 13 - - HYPH 10_1101-2020_03_27_012757 67 14 seq seq NN 10_1101-2020_03_27_012757 67 15 and and CC 10_1101-2020_03_27_012757 67 16 183 183 CD 10_1101-2020_03_27_012757 67 17 microarray microarray JJ 10_1101-2020_03_27_012757 67 18 expression expression NN 10_1101-2020_03_27_012757 67 19 profiles profile NNS 10_1101-2020_03_27_012757 67 20 , , , 10_1101-2020_03_27_012757 67 21 we -PRON- PRP 10_1101-2020_03_27_012757 67 22 found find VBD 10_1101-2020_03_27_012757 67 23 a a DT 10_1101-2020_03_27_012757 67 24 strong strong JJ 10_1101-2020_03_27_012757 67 25 overall overall JJ 10_1101-2020_03_27_012757 67 26 positive positive JJ 10_1101-2020_03_27_012757 67 27 association association NN 10_1101-2020_03_27_012757 67 28 between between IN 10_1101-2020_03_27_012757 67 29 the the DT 10_1101-2020_03_27_012757 67 30 184 184 CD 10_1101-2020_03_27_012757 67 31 classification classification NN 10_1101-2020_03_27_012757 67 32 scores score NNS 10_1101-2020_03_27_012757 67 33 from from IN 10_1101-2020_03_27_012757 67 34 RNA RNA NNP 10_1101-2020_03_27_012757 67 35 - - HYPH 10_1101-2020_03_27_012757 67 36 seq seq NN 10_1101-2020_03_27_012757 67 37 and and CC 10_1101-2020_03_27_012757 67 38 those those DT 10_1101-2020_03_27_012757 67 39 from from IN 10_1101-2020_03_27_012757 67 40 microarray microarray JJ 10_1101-2020_03_27_012757 67 41 ( ( -LRB- 10_1101-2020_03_27_012757 67 42 Supp Supp NNP 10_1101-2020_03_27_012757 67 43 Fig Fig NNP 10_1101-2020_03_27_012757 67 44 2C 2c NN 10_1101-2020_03_27_012757 67 45 ) ) -RRB- 10_1101-2020_03_27_012757 67 46 . . . 10_1101-2020_03_27_012757 68 1 This this DT 10_1101-2020_03_27_012757 68 2 comparison comparison NN 10_1101-2020_03_27_012757 68 3 185 185 CD 10_1101-2020_03_27_012757 68 4 supports support VBZ 10_1101-2020_03_27_012757 68 5 the the DT 10_1101-2020_03_27_012757 68 6 notion notion NN 10_1101-2020_03_27_012757 68 7 that that IN 10_1101-2020_03_27_012757 68 8 the the DT 10_1101-2020_03_27_012757 68 9 classification classification NN 10_1101-2020_03_27_012757 68 10 scores score NNS 10_1101-2020_03_27_012757 68 11 for for IN 10_1101-2020_03_27_012757 68 12 each each DT 10_1101-2020_03_27_012757 68 13 cell cell NN 10_1101-2020_03_27_012757 68 14 line line NN 10_1101-2020_03_27_012757 68 15 are be VBP 10_1101-2020_03_27_012757 68 16 not not RB 10_1101-2020_03_27_012757 68 17 artifacts artifact NNS 10_1101-2020_03_27_012757 68 18 of of IN 10_1101-2020_03_27_012757 68 19 profiling profile VBG 10_1101-2020_03_27_012757 68 20 186 186 CD 10_1101-2020_03_27_012757 68 21 methodology methodology NN 10_1101-2020_03_27_012757 68 22 . . . 10_1101-2020_03_27_012757 69 1 Moreover moreover RB 10_1101-2020_03_27_012757 69 2 , , , 10_1101-2020_03_27_012757 69 3 this this DT 10_1101-2020_03_27_012757 69 4 comparison comparison NN 10_1101-2020_03_27_012757 69 5 shows show VBZ 10_1101-2020_03_27_012757 69 6 that that IN 10_1101-2020_03_27_012757 69 7 the the DT 10_1101-2020_03_27_012757 69 8 scores score NNS 10_1101-2020_03_27_012757 69 9 are be VBP 10_1101-2020_03_27_012757 69 10 consistent consistent JJ 10_1101-2020_03_27_012757 69 11 between between IN 10_1101-2020_03_27_012757 69 12 the the DT 10_1101-2020_03_27_012757 69 13 187 187 CD 10_1101-2020_03_27_012757 69 14 times time NNS 10_1101-2020_03_27_012757 69 15 that that IN 10_1101-2020_03_27_012757 69 16 the the DT 10_1101-2020_03_27_012757 69 17 cell cell NN 10_1101-2020_03_27_012757 69 18 lines line NNS 10_1101-2020_03_27_012757 69 19 were be VBD 10_1101-2020_03_27_012757 69 20 first first RB 10_1101-2020_03_27_012757 69 21 assayed assay VBN 10_1101-2020_03_27_012757 69 22 by by IN 10_1101-2020_03_27_012757 69 23 microarray microarray JJ 10_1101-2020_03_27_012757 69 24 expression expression NN 10_1101-2020_03_27_012757 69 25 profiling profiling NN 10_1101-2020_03_27_012757 69 26 in in IN 10_1101-2020_03_27_012757 69 27 2012 2012 CD 10_1101-2020_03_27_012757 69 28 and and CC 10_1101-2020_03_27_012757 69 29 by by IN 10_1101-2020_03_27_012757 69 30 188 188 CD 10_1101-2020_03_27_012757 69 31 .CC .CC , 10_1101-2020_03_27_012757 69 32 - - HYPH 10_1101-2020_03_27_012757 69 33 BY by IN 10_1101-2020_03_27_012757 69 34 - - HYPH 10_1101-2020_03_27_012757 69 35 NC NC NNP 10_1101-2020_03_27_012757 69 36 - - HYPH 10_1101-2020_03_27_012757 69 37 ND ND NNP 10_1101-2020_03_27_012757 69 38 4.0 4.0 CD 10_1101-2020_03_27_012757 69 39 International International NNP 10_1101-2020_03_27_012757 69 40 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 69 41 under under IN 10_1101-2020_03_27_012757 69 42 a a DT 10_1101-2020_03_27_012757 69 43 ( ( -LRB- 10_1101-2020_03_27_012757 69 44 which which WDT 10_1101-2020_03_27_012757 69 45 was be VBD 10_1101-2020_03_27_012757 69 46 not not RB 10_1101-2020_03_27_012757 69 47 certified certify VBN 10_1101-2020_03_27_012757 69 48 by by IN 10_1101-2020_03_27_012757 69 49 peer peer NN 10_1101-2020_03_27_012757 69 50 review review NN 10_1101-2020_03_27_012757 69 51 ) ) -RRB- 10_1101-2020_03_27_012757 69 52 is be VBZ 10_1101-2020_03_27_012757 69 53 the the DT 10_1101-2020_03_27_012757 69 54 author author NN 10_1101-2020_03_27_012757 69 55 / / SYM 10_1101-2020_03_27_012757 69 56 funder funder NN 10_1101-2020_03_27_012757 69 57 , , , 10_1101-2020_03_27_012757 69 58 who who WP 10_1101-2020_03_27_012757 69 59 has have VBZ 10_1101-2020_03_27_012757 69 60 granted grant VBN 10_1101-2020_03_27_012757 69 61 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 69 62 a a DT 10_1101-2020_03_27_012757 69 63 license license NN 10_1101-2020_03_27_012757 69 64 to to TO 10_1101-2020_03_27_012757 69 65 display display VB 10_1101-2020_03_27_012757 69 66 the the DT 10_1101-2020_03_27_012757 69 67 preprint preprint NN 10_1101-2020_03_27_012757 69 68 in in IN 10_1101-2020_03_27_012757 69 69 perpetuity perpetuity NN 10_1101-2020_03_27_012757 69 70 . . . 10_1101-2020_03_27_012757 70 1 It -PRON- PRP 10_1101-2020_03_27_012757 70 2 is be VBZ 10_1101-2020_03_27_012757 70 3 made make VBN 10_1101-2020_03_27_012757 70 4 The the DT 10_1101-2020_03_27_012757 70 5 copyright copyright NN 10_1101-2020_03_27_012757 70 6 holder holder NN 10_1101-2020_03_27_012757 70 7 for for IN 10_1101-2020_03_27_012757 70 8 this this DT 10_1101-2020_03_27_012757 70 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 70 10 version version NN 10_1101-2020_03_27_012757 70 11 posted post VBD 10_1101-2020_03_27_012757 70 12 January January NNP 10_1101-2020_03_27_012757 70 13 9 9 CD 10_1101-2020_03_27_012757 70 14 , , , 10_1101-2020_03_27_012757 70 15 2021 2021 CD 10_1101-2020_03_27_012757 70 16 . . . 10_1101-2020_03_27_012757 70 17 ; ; : 10_1101-2020_03_27_012757 70 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 70 19 : : : 10_1101-2020_03_27_012757 70 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 70 21 preprint preprint NN 10_1101-2020_03_27_012757 70 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 70 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 70 24 7 7 CD 10_1101-2020_03_27_012757 70 25 RNA RNA NNP 10_1101-2020_03_27_012757 70 26 - - HYPH 10_1101-2020_03_27_012757 70 27 Seq Seq NNP 10_1101-2020_03_27_012757 70 28 in in IN 10_1101-2020_03_27_012757 70 29 2019 2019 CD 10_1101-2020_03_27_012757 70 30 . . . 10_1101-2020_03_27_012757 71 1 We -PRON- PRP 10_1101-2020_03_27_012757 71 2 also also RB 10_1101-2020_03_27_012757 71 3 observed observe VBD 10_1101-2020_03_27_012757 71 4 high high JJ 10_1101-2020_03_27_012757 71 5 level level NN 10_1101-2020_03_27_012757 71 6 of of IN 10_1101-2020_03_27_012757 71 7 correlation correlation NN 10_1101-2020_03_27_012757 71 8 between between IN 10_1101-2020_03_27_012757 71 9 our -PRON- PRP$ 10_1101-2020_03_27_012757 71 10 analysis analysis NN 10_1101-2020_03_27_012757 71 11 and and CC 10_1101-2020_03_27_012757 71 12 the the DT 10_1101-2020_03_27_012757 71 13 189 189 CD 10_1101-2020_03_27_012757 71 14 analysis analysis NN 10_1101-2020_03_27_012757 71 15 done do VBN 10_1101-2020_03_27_012757 71 16 by by IN 10_1101-2020_03_27_012757 71 17 Yu Yu NNP 10_1101-2020_03_27_012757 71 18 et et NNP 10_1101-2020_03_27_012757 71 19 al15(Supp al15(Supp NNP 10_1101-2020_03_27_012757 71 20 Fig Fig NNP 10_1101-2020_03_27_012757 71 21 2D 2d NN 10_1101-2020_03_27_012757 71 22 ) ) -RRB- 10_1101-2020_03_27_012757 71 23 , , , 10_1101-2020_03_27_012757 71 24 further further RB 10_1101-2020_03_27_012757 71 25 validating validate VBG 10_1101-2020_03_27_012757 71 26 the the DT 10_1101-2020_03_27_012757 71 27 robustness robustness NN 10_1101-2020_03_27_012757 71 28 of of IN 10_1101-2020_03_27_012757 71 29 the the DT 10_1101-2020_03_27_012757 71 30 CCN CCN NNP 10_1101-2020_03_27_012757 71 31 results result NNS 10_1101-2020_03_27_012757 71 32 . . . 10_1101-2020_03_27_012757 72 1 190 190 CD 10_1101-2020_03_27_012757 72 2 Next next JJ 10_1101-2020_03_27_012757 72 3 , , , 10_1101-2020_03_27_012757 72 4 we -PRON- PRP 10_1101-2020_03_27_012757 72 5 assessed assess VBD 10_1101-2020_03_27_012757 72 6 the the DT 10_1101-2020_03_27_012757 72 7 extent extent NN 10_1101-2020_03_27_012757 72 8 to to TO 10_1101-2020_03_27_012757 72 9 which which WDT 10_1101-2020_03_27_012757 72 10 CCN CCN NNP 10_1101-2020_03_27_012757 72 11 classifications classification NNS 10_1101-2020_03_27_012757 72 12 agreed agree VBD 10_1101-2020_03_27_012757 72 13 with with IN 10_1101-2020_03_27_012757 72 14 their -PRON- PRP$ 10_1101-2020_03_27_012757 72 15 nominal nominal JJ 10_1101-2020_03_27_012757 72 16 191 191 CD 10_1101-2020_03_27_012757 72 17 tumor tumor NN 10_1101-2020_03_27_012757 72 18 type type NN 10_1101-2020_03_27_012757 72 19 of of IN 10_1101-2020_03_27_012757 72 20 origin origin NN 10_1101-2020_03_27_012757 72 21 , , , 10_1101-2020_03_27_012757 72 22 which which WDT 10_1101-2020_03_27_012757 72 23 entailed entail VBD 10_1101-2020_03_27_012757 72 24 translating translate VBG 10_1101-2020_03_27_012757 72 25 quantitative quantitative JJ 10_1101-2020_03_27_012757 72 26 CCN CCN NNP 10_1101-2020_03_27_012757 72 27 scores score NNS 10_1101-2020_03_27_012757 72 28 to to TO 10_1101-2020_03_27_012757 72 29 classification classification NN 10_1101-2020_03_27_012757 72 30 labels label NNS 10_1101-2020_03_27_012757 72 31 . . . 10_1101-2020_03_27_012757 73 1 192 192 CD 10_1101-2020_03_27_012757 73 2 To to TO 10_1101-2020_03_27_012757 73 3 achieve achieve VB 10_1101-2020_03_27_012757 73 4 this this DT 10_1101-2020_03_27_012757 73 5 , , , 10_1101-2020_03_27_012757 73 6 we -PRON- PRP 10_1101-2020_03_27_012757 73 7 selected select VBD 10_1101-2020_03_27_012757 73 8 a a DT 10_1101-2020_03_27_012757 73 9 decision decision NN 10_1101-2020_03_27_012757 73 10 threshold threshold NN 10_1101-2020_03_27_012757 73 11 that that WDT 10_1101-2020_03_27_012757 73 12 maximized maximize VBD 10_1101-2020_03_27_012757 73 13 the the DT 10_1101-2020_03_27_012757 73 14 Macro Macro NNP 10_1101-2020_03_27_012757 73 15 F1 F1 NNP 10_1101-2020_03_27_012757 73 16 measure measure NN 10_1101-2020_03_27_012757 73 17 , , , 10_1101-2020_03_27_012757 73 18 193 193 CD 10_1101-2020_03_27_012757 73 19 harmonic harmonic JJ 10_1101-2020_03_27_012757 73 20 mean mean NN 10_1101-2020_03_27_012757 73 21 of of IN 10_1101-2020_03_27_012757 73 22 precision precision NN 10_1101-2020_03_27_012757 73 23 and and CC 10_1101-2020_03_27_012757 73 24 recall recall NN 10_1101-2020_03_27_012757 73 25 , , , 10_1101-2020_03_27_012757 73 26 across across IN 10_1101-2020_03_27_012757 73 27 50 50 CD 10_1101-2020_03_27_012757 73 28 cross cross NN 10_1101-2020_03_27_012757 73 29 validations validation NNS 10_1101-2020_03_27_012757 73 30 . . . 10_1101-2020_03_27_012757 74 1 Then then RB 10_1101-2020_03_27_012757 74 2 , , , 10_1101-2020_03_27_012757 74 3 we -PRON- PRP 10_1101-2020_03_27_012757 74 4 annotated annotate VBD 10_1101-2020_03_27_012757 74 5 cell cell NN 10_1101-2020_03_27_012757 74 6 194 194 CD 10_1101-2020_03_27_012757 74 7 lines line NNS 10_1101-2020_03_27_012757 74 8 based base VBD 10_1101-2020_03_27_012757 74 9 their -PRON- PRP$ 10_1101-2020_03_27_012757 74 10 CCN CCN NNP 10_1101-2020_03_27_012757 74 11 score score VBP 10_1101-2020_03_27_012757 74 12 profile profile RB 10_1101-2020_03_27_012757 74 13 as as IN 10_1101-2020_03_27_012757 74 14 follows follow VBZ 10_1101-2020_03_27_012757 74 15 . . . 10_1101-2020_03_27_012757 75 1 Cell cell NN 10_1101-2020_03_27_012757 75 2 lines line NNS 10_1101-2020_03_27_012757 75 3 with with IN 10_1101-2020_03_27_012757 75 4 CCN CCN NNP 10_1101-2020_03_27_012757 75 5 scores score NNS 10_1101-2020_03_27_012757 75 6 > > XX 10_1101-2020_03_27_012757 75 7 threshold threshold NN 10_1101-2020_03_27_012757 75 8 for for IN 10_1101-2020_03_27_012757 75 9 the the DT 10_1101-2020_03_27_012757 75 10 195 195 CD 10_1101-2020_03_27_012757 75 11 tumor tumor NN 10_1101-2020_03_27_012757 75 12 type type NN 10_1101-2020_03_27_012757 75 13 of of IN 10_1101-2020_03_27_012757 75 14 origin origin NN 10_1101-2020_03_27_012757 75 15 were be VBD 10_1101-2020_03_27_012757 75 16 annotated annotate VBN 10_1101-2020_03_27_012757 75 17 as as IN 10_1101-2020_03_27_012757 75 18 ' ' `` 10_1101-2020_03_27_012757 75 19 correct correct JJ 10_1101-2020_03_27_012757 75 20 ' ' '' 10_1101-2020_03_27_012757 75 21 . . . 10_1101-2020_03_27_012757 76 1 Cell cell NN 10_1101-2020_03_27_012757 76 2 lines line NNS 10_1101-2020_03_27_012757 76 3 with with IN 10_1101-2020_03_27_012757 76 4 CCN CCN NNP 10_1101-2020_03_27_012757 76 5 scores score NNS 10_1101-2020_03_27_012757 76 6 > > XX 10_1101-2020_03_27_012757 76 7 threshold threshold NN 10_1101-2020_03_27_012757 76 8 in in IN 10_1101-2020_03_27_012757 76 9 the the DT 10_1101-2020_03_27_012757 76 10 196 196 CD 10_1101-2020_03_27_012757 76 11 tumor tumor NN 10_1101-2020_03_27_012757 76 12 type type NN 10_1101-2020_03_27_012757 76 13 of of IN 10_1101-2020_03_27_012757 76 14 origin origin NN 10_1101-2020_03_27_012757 76 15 and and CC 10_1101-2020_03_27_012757 76 16 at at RB 10_1101-2020_03_27_012757 76 17 least least RBS 10_1101-2020_03_27_012757 76 18 one one CD 10_1101-2020_03_27_012757 76 19 other other JJ 10_1101-2020_03_27_012757 76 20 tumor tumor NN 10_1101-2020_03_27_012757 76 21 type type NN 10_1101-2020_03_27_012757 76 22 were be VBD 10_1101-2020_03_27_012757 76 23 annotated annotate VBN 10_1101-2020_03_27_012757 76 24 as as IN 10_1101-2020_03_27_012757 76 25 ' ' `` 10_1101-2020_03_27_012757 76 26 mixed mixed JJ 10_1101-2020_03_27_012757 76 27 ' ' '' 10_1101-2020_03_27_012757 76 28 . . . 10_1101-2020_03_27_012757 77 1 Cell cell NN 10_1101-2020_03_27_012757 77 2 lines line NNS 10_1101-2020_03_27_012757 77 3 with with IN 10_1101-2020_03_27_012757 77 4 197 197 CD 10_1101-2020_03_27_012757 77 5 CCN CCN NNP 10_1101-2020_03_27_012757 77 6 scores score NNS 10_1101-2020_03_27_012757 77 7 > > XX 10_1101-2020_03_27_012757 77 8 threshold threshold NN 10_1101-2020_03_27_012757 77 9 for for IN 10_1101-2020_03_27_012757 77 10 tumor tumor NN 10_1101-2020_03_27_012757 77 11 types type NNS 10_1101-2020_03_27_012757 77 12 other other JJ 10_1101-2020_03_27_012757 77 13 than than IN 10_1101-2020_03_27_012757 77 14 that that DT 10_1101-2020_03_27_012757 77 15 of of IN 10_1101-2020_03_27_012757 77 16 the the DT 10_1101-2020_03_27_012757 77 17 cell cell NN 10_1101-2020_03_27_012757 77 18 line line NN 10_1101-2020_03_27_012757 77 19 's 's POS 10_1101-2020_03_27_012757 77 20 origin origin NN 10_1101-2020_03_27_012757 77 21 were be VBD 10_1101-2020_03_27_012757 77 22 annotated annotate VBN 10_1101-2020_03_27_012757 77 23 198 198 CD 10_1101-2020_03_27_012757 77 24 as as IN 10_1101-2020_03_27_012757 77 25 ' ' `` 10_1101-2020_03_27_012757 77 26 other other JJ 10_1101-2020_03_27_012757 77 27 ' ' '' 10_1101-2020_03_27_012757 77 28 . . . 10_1101-2020_03_27_012757 78 1 Cell cell NN 10_1101-2020_03_27_012757 78 2 lines line NNS 10_1101-2020_03_27_012757 78 3 that that WDT 10_1101-2020_03_27_012757 78 4 did do VBD 10_1101-2020_03_27_012757 78 5 not not RB 10_1101-2020_03_27_012757 78 6 receive receive VB 10_1101-2020_03_27_012757 78 7 a a DT 10_1101-2020_03_27_012757 78 8 CCN CCN NNP 10_1101-2020_03_27_012757 78 9 score score NN 10_1101-2020_03_27_012757 78 10 > > XX 10_1101-2020_03_27_012757 78 11 threshold threshold NN 10_1101-2020_03_27_012757 78 12 for for IN 10_1101-2020_03_27_012757 78 13 any any DT 10_1101-2020_03_27_012757 78 14 tumor tumor NN 10_1101-2020_03_27_012757 78 15 type type NN 10_1101-2020_03_27_012757 78 16 were be VBD 10_1101-2020_03_27_012757 78 17 199 199 CD 10_1101-2020_03_27_012757 78 18 annotated annotate VBN 10_1101-2020_03_27_012757 78 19 as as IN 10_1101-2020_03_27_012757 78 20 ' ' `` 10_1101-2020_03_27_012757 78 21 none none NN 10_1101-2020_03_27_012757 78 22 ' ' '' 10_1101-2020_03_27_012757 78 23 ( ( -LRB- 10_1101-2020_03_27_012757 78 24 Fig fig NN 10_1101-2020_03_27_012757 78 25 2B 2b NN 10_1101-2020_03_27_012757 78 26 ) ) -RRB- 10_1101-2020_03_27_012757 78 27 . . . 10_1101-2020_03_27_012757 79 1 We -PRON- PRP 10_1101-2020_03_27_012757 79 2 found find VBD 10_1101-2020_03_27_012757 79 3 that that IN 10_1101-2020_03_27_012757 79 4 majority majority NN 10_1101-2020_03_27_012757 79 5 of of IN 10_1101-2020_03_27_012757 79 6 cell cell NN 10_1101-2020_03_27_012757 79 7 lines line NNS 10_1101-2020_03_27_012757 79 8 originally originally RB 10_1101-2020_03_27_012757 79 9 annotated annotate VBD 10_1101-2020_03_27_012757 79 10 as as IN 10_1101-2020_03_27_012757 79 11 Breast Breast NNP 10_1101-2020_03_27_012757 79 12 200 200 CD 10_1101-2020_03_27_012757 79 13 invasive invasive JJ 10_1101-2020_03_27_012757 79 14 carcinoma carcinoma NN 10_1101-2020_03_27_012757 79 15 ( ( -LRB- 10_1101-2020_03_27_012757 79 16 BRCA BRCA NNP 10_1101-2020_03_27_012757 79 17 ) ) -RRB- 10_1101-2020_03_27_012757 79 18 , , , 10_1101-2020_03_27_012757 79 19 Cervical cervical JJ 10_1101-2020_03_27_012757 79 20 squamous squamous JJ 10_1101-2020_03_27_012757 79 21 cell cell NN 10_1101-2020_03_27_012757 79 22 carcinoma carcinoma NN 10_1101-2020_03_27_012757 79 23 and and CC 10_1101-2020_03_27_012757 79 24 endocervical endocervical JJ 10_1101-2020_03_27_012757 79 25 201 201 CD 10_1101-2020_03_27_012757 79 26 adenocarcinoma adenocarcinoma NNS 10_1101-2020_03_27_012757 79 27 ( ( -LRB- 10_1101-2020_03_27_012757 79 28 CESC CESC NNP 10_1101-2020_03_27_012757 79 29 ) ) -RRB- 10_1101-2020_03_27_012757 79 30 , , , 10_1101-2020_03_27_012757 79 31 Skin Skin NNP 10_1101-2020_03_27_012757 79 32 Cutaneous Cutaneous NNP 10_1101-2020_03_27_012757 79 33 Melanoma Melanoma NNP 10_1101-2020_03_27_012757 79 34 ( ( -LRB- 10_1101-2020_03_27_012757 79 35 SKCM SKCM NNP 10_1101-2020_03_27_012757 79 36 ) ) -RRB- 10_1101-2020_03_27_012757 79 37 , , , 10_1101-2020_03_27_012757 79 38 Colorectal Colorectal NNP 10_1101-2020_03_27_012757 79 39 Cancer Cancer NNP 10_1101-2020_03_27_012757 79 40 202 202 CD 10_1101-2020_03_27_012757 79 41 ( ( -LRB- 10_1101-2020_03_27_012757 79 42 COAD_READ coad_read NN 10_1101-2020_03_27_012757 79 43 ) ) -RRB- 10_1101-2020_03_27_012757 79 44 and and CC 10_1101-2020_03_27_012757 79 45 Sarcoma Sarcoma NNP 10_1101-2020_03_27_012757 79 46 ( ( -LRB- 10_1101-2020_03_27_012757 79 47 SARC SARC NNP 10_1101-2020_03_27_012757 79 48 ) ) -RRB- 10_1101-2020_03_27_012757 79 49 fell fall VBD 10_1101-2020_03_27_012757 79 50 into into IN 10_1101-2020_03_27_012757 79 51 the the DT 10_1101-2020_03_27_012757 79 52 ' ' `` 10_1101-2020_03_27_012757 79 53 correct correct JJ 10_1101-2020_03_27_012757 79 54 ' ' '' 10_1101-2020_03_27_012757 79 55 category category NN 10_1101-2020_03_27_012757 79 56 ( ( -LRB- 10_1101-2020_03_27_012757 79 57 Fig fig NN 10_1101-2020_03_27_012757 79 58 2B 2b NN 10_1101-2020_03_27_012757 79 59 ) ) -RRB- 10_1101-2020_03_27_012757 79 60 . . . 10_1101-2020_03_27_012757 80 1 On on IN 10_1101-2020_03_27_012757 80 2 the the DT 10_1101-2020_03_27_012757 80 3 other other JJ 10_1101-2020_03_27_012757 80 4 203 203 CD 10_1101-2020_03_27_012757 80 5 hand hand NN 10_1101-2020_03_27_012757 80 6 , , , 10_1101-2020_03_27_012757 80 7 no no DT 10_1101-2020_03_27_012757 80 8 Esophageal esophageal JJ 10_1101-2020_03_27_012757 80 9 carcinoma carcinoma NN 10_1101-2020_03_27_012757 80 10 ( ( -LRB- 10_1101-2020_03_27_012757 80 11 ESCA ESCA NNP 10_1101-2020_03_27_012757 80 12 ) ) -RRB- 10_1101-2020_03_27_012757 80 13 , , , 10_1101-2020_03_27_012757 80 14 Pancreatic pancreatic JJ 10_1101-2020_03_27_012757 80 15 adenocarcinoma adenocarcinoma NN 10_1101-2020_03_27_012757 80 16 ( ( -LRB- 10_1101-2020_03_27_012757 80 17 PAAD PAAD NNP 10_1101-2020_03_27_012757 80 18 ) ) -RRB- 10_1101-2020_03_27_012757 80 19 or or CC 10_1101-2020_03_27_012757 80 20 Brain Brain NNP 10_1101-2020_03_27_012757 80 21 Lower low JJR 10_1101-2020_03_27_012757 80 22 204 204 CD 10_1101-2020_03_27_012757 80 23 Grade Grade NNP 10_1101-2020_03_27_012757 80 24 Glioma Glioma NNP 10_1101-2020_03_27_012757 80 25 ( ( -LRB- 10_1101-2020_03_27_012757 80 26 LGG LGG NNP 10_1101-2020_03_27_012757 80 27 ) ) -RRB- 10_1101-2020_03_27_012757 80 28 were be VBD 10_1101-2020_03_27_012757 80 29 classified classify VBN 10_1101-2020_03_27_012757 80 30 as as IN 10_1101-2020_03_27_012757 80 31 ' ' `` 10_1101-2020_03_27_012757 80 32 correct correct JJ 10_1101-2020_03_27_012757 80 33 ' ' '' 10_1101-2020_03_27_012757 80 34 , , , 10_1101-2020_03_27_012757 80 35 demonstrating demonstrate VBG 10_1101-2020_03_27_012757 80 36 the the DT 10_1101-2020_03_27_012757 80 37 need need NN 10_1101-2020_03_27_012757 80 38 for for IN 10_1101-2020_03_27_012757 80 39 more more JJR 10_1101-2020_03_27_012757 80 40 205 205 CD 10_1101-2020_03_27_012757 80 41 transcriptionally transcriptionally RB 10_1101-2020_03_27_012757 80 42 faithful faithful JJ 10_1101-2020_03_27_012757 80 43 cell cell NN 10_1101-2020_03_27_012757 80 44 lines line NNS 10_1101-2020_03_27_012757 80 45 that that WDT 10_1101-2020_03_27_012757 80 46 model model VBP 10_1101-2020_03_27_012757 80 47 those those DT 10_1101-2020_03_27_012757 80 48 general general JJ 10_1101-2020_03_27_012757 80 49 cancer cancer NN 10_1101-2020_03_27_012757 80 50 types type NNS 10_1101-2020_03_27_012757 80 51 . . . 10_1101-2020_03_27_012757 81 1 206 206 CD 10_1101-2020_03_27_012757 81 2 There there EX 10_1101-2020_03_27_012757 81 3 are be VBP 10_1101-2020_03_27_012757 81 4 several several JJ 10_1101-2020_03_27_012757 81 5 possible possible JJ 10_1101-2020_03_27_012757 81 6 explanations explanation NNS 10_1101-2020_03_27_012757 81 7 for for IN 10_1101-2020_03_27_012757 81 8 cell cell NN 10_1101-2020_03_27_012757 81 9 lines line NNS 10_1101-2020_03_27_012757 81 10 not not RB 10_1101-2020_03_27_012757 81 11 receiving receive VBG 10_1101-2020_03_27_012757 81 12 a a DT 10_1101-2020_03_27_012757 81 13 ' ' `` 10_1101-2020_03_27_012757 81 14 correct correct JJ 10_1101-2020_03_27_012757 81 15 ' ' '' 10_1101-2020_03_27_012757 81 16 207 207 CD 10_1101-2020_03_27_012757 81 17 classification classification NN 10_1101-2020_03_27_012757 81 18 . . . 10_1101-2020_03_27_012757 82 1 One one CD 10_1101-2020_03_27_012757 82 2 possibility possibility NN 10_1101-2020_03_27_012757 82 3 is be VBZ 10_1101-2020_03_27_012757 82 4 that that IN 10_1101-2020_03_27_012757 82 5 the the DT 10_1101-2020_03_27_012757 82 6 sample sample NN 10_1101-2020_03_27_012757 82 7 was be VBD 10_1101-2020_03_27_012757 82 8 incorrectly incorrectly RB 10_1101-2020_03_27_012757 82 9 labeled label VBN 10_1101-2020_03_27_012757 82 10 in in IN 10_1101-2020_03_27_012757 82 11 the the DT 10_1101-2020_03_27_012757 82 12 study study NN 10_1101-2020_03_27_012757 82 13 from from IN 10_1101-2020_03_27_012757 82 14 which which WDT 10_1101-2020_03_27_012757 82 15 208 208 CD 10_1101-2020_03_27_012757 82 16 we -PRON- PRP 10_1101-2020_03_27_012757 82 17 harvested harvest VBD 10_1101-2020_03_27_012757 82 18 the the DT 10_1101-2020_03_27_012757 82 19 expression expression NN 10_1101-2020_03_27_012757 82 20 data datum NNS 10_1101-2020_03_27_012757 82 21 . . . 10_1101-2020_03_27_012757 83 1 Consistent consistent JJ 10_1101-2020_03_27_012757 83 2 with with IN 10_1101-2020_03_27_012757 83 3 this this DT 10_1101-2020_03_27_012757 83 4 explanation explanation NN 10_1101-2020_03_27_012757 83 5 , , , 10_1101-2020_03_27_012757 83 6 we -PRON- PRP 10_1101-2020_03_27_012757 83 7 found find VBD 10_1101-2020_03_27_012757 83 8 that that IN 10_1101-2020_03_27_012757 83 9 colorectal colorectal JJ 10_1101-2020_03_27_012757 83 10 209 209 CD 10_1101-2020_03_27_012757 83 11 cancer cancer NN 10_1101-2020_03_27_012757 83 12 line line NN 10_1101-2020_03_27_012757 83 13 NCI NCI NNP 10_1101-2020_03_27_012757 83 14 - - HYPH 10_1101-2020_03_27_012757 83 15 H68438,39 H68438,39 NNP 10_1101-2020_03_27_012757 83 16 , , , 10_1101-2020_03_27_012757 83 17 a a DT 10_1101-2020_03_27_012757 83 18 cell cell NN 10_1101-2020_03_27_012757 83 19 line line NN 10_1101-2020_03_27_012757 83 20 labelled label VBN 10_1101-2020_03_27_012757 83 21 as as IN 10_1101-2020_03_27_012757 83 22 liver liver NNP 10_1101-2020_03_27_012757 83 23 hepatocellular hepatocellular NNP 10_1101-2020_03_27_012757 83 24 carcinoma carcinoma NNP 10_1101-2020_03_27_012757 83 25 ( ( -LRB- 10_1101-2020_03_27_012757 83 26 LIHC LIHC NNP 10_1101-2020_03_27_012757 83 27 ) ) -RRB- 10_1101-2020_03_27_012757 83 28 by by IN 10_1101-2020_03_27_012757 83 29 CCLE CCLE NNP 10_1101-2020_03_27_012757 83 30 , , , 10_1101-2020_03_27_012757 83 31 210 210 CD 10_1101-2020_03_27_012757 83 32 was be VBD 10_1101-2020_03_27_012757 83 33 classified classify VBN 10_1101-2020_03_27_012757 83 34 strongly strongly RB 10_1101-2020_03_27_012757 83 35 as as IN 10_1101-2020_03_27_012757 83 36 COAD_READ coad_read RB 10_1101-2020_03_27_012757 83 37 ( ( -LRB- 10_1101-2020_03_27_012757 83 38 Supp Supp NNP 10_1101-2020_03_27_012757 83 39 Tab Tab NNP 10_1101-2020_03_27_012757 83 40 1 1 CD 10_1101-2020_03_27_012757 83 41 ) ) -RRB- 10_1101-2020_03_27_012757 83 42 . . . 10_1101-2020_03_27_012757 84 1 Another another DT 10_1101-2020_03_27_012757 84 2 possibility possibility NN 10_1101-2020_03_27_012757 84 3 to to TO 10_1101-2020_03_27_012757 84 4 explain explain VB 10_1101-2020_03_27_012757 84 5 low low JJ 10_1101-2020_03_27_012757 84 6 CCN CCN NNP 10_1101-2020_03_27_012757 84 7 211 211 CD 10_1101-2020_03_27_012757 84 8 score score NN 10_1101-2020_03_27_012757 84 9 is be VBZ 10_1101-2020_03_27_012757 84 10 that that IN 10_1101-2020_03_27_012757 84 11 cell cell NN 10_1101-2020_03_27_012757 84 12 lines line NNS 10_1101-2020_03_27_012757 84 13 were be VBD 10_1101-2020_03_27_012757 84 14 derived derive VBN 10_1101-2020_03_27_012757 84 15 from from IN 10_1101-2020_03_27_012757 84 16 subtypes subtype NNS 10_1101-2020_03_27_012757 84 17 of of IN 10_1101-2020_03_27_012757 84 18 tumors tumor NNS 10_1101-2020_03_27_012757 84 19 that that WDT 10_1101-2020_03_27_012757 84 20 are be VBP 10_1101-2020_03_27_012757 84 21 not not RB 10_1101-2020_03_27_012757 84 22 well well RB 10_1101-2020_03_27_012757 84 23 - - HYPH 10_1101-2020_03_27_012757 84 24 represented represent VBN 10_1101-2020_03_27_012757 84 25 in in IN 10_1101-2020_03_27_012757 84 26 212 212 CD 10_1101-2020_03_27_012757 84 27 TCGA tcga NN 10_1101-2020_03_27_012757 84 28 . . . 10_1101-2020_03_27_012757 85 1 To to TO 10_1101-2020_03_27_012757 85 2 explore explore VB 10_1101-2020_03_27_012757 85 3 this this DT 10_1101-2020_03_27_012757 85 4 hypothesis hypothesis NN 10_1101-2020_03_27_012757 85 5 , , , 10_1101-2020_03_27_012757 85 6 we -PRON- PRP 10_1101-2020_03_27_012757 85 7 first first RB 10_1101-2020_03_27_012757 85 8 performed perform VBD 10_1101-2020_03_27_012757 85 9 tumor tumor NN 10_1101-2020_03_27_012757 85 10 subtype subtype NN 10_1101-2020_03_27_012757 85 11 classification classification NN 10_1101-2020_03_27_012757 85 12 on on IN 10_1101-2020_03_27_012757 85 13 CCLs CCLs NNP 10_1101-2020_03_27_012757 85 14 from from IN 10_1101-2020_03_27_012757 85 15 213 213 CD 10_1101-2020_03_27_012757 85 16 11 11 CD 10_1101-2020_03_27_012757 85 17 tumor tumor NN 10_1101-2020_03_27_012757 85 18 types type NNS 10_1101-2020_03_27_012757 85 19 for for IN 10_1101-2020_03_27_012757 85 20 which which WDT 10_1101-2020_03_27_012757 85 21 we -PRON- PRP 10_1101-2020_03_27_012757 85 22 had have VBD 10_1101-2020_03_27_012757 85 23 trained train VBN 10_1101-2020_03_27_012757 85 24 subtype subtype NN 10_1101-2020_03_27_012757 85 25 classifiers classifier NNS 10_1101-2020_03_27_012757 85 26 ( ( -LRB- 10_1101-2020_03_27_012757 85 27 Supp Supp NNP 10_1101-2020_03_27_012757 85 28 Tab Tab NNP 10_1101-2020_03_27_012757 85 29 2 2 CD 10_1101-2020_03_27_012757 85 30 ) ) -RRB- 10_1101-2020_03_27_012757 85 31 . . . 10_1101-2020_03_27_012757 86 1 We -PRON- PRP 10_1101-2020_03_27_012757 86 2 reasoned reason VBD 10_1101-2020_03_27_012757 86 3 that that IN 10_1101-2020_03_27_012757 86 4 if if IN 10_1101-2020_03_27_012757 86 5 214 214 CD 10_1101-2020_03_27_012757 86 6 .CC .CC NFP 10_1101-2020_03_27_012757 86 7 - - HYPH 10_1101-2020_03_27_012757 86 8 BY by IN 10_1101-2020_03_27_012757 86 9 - - HYPH 10_1101-2020_03_27_012757 86 10 NC NC NNP 10_1101-2020_03_27_012757 86 11 - - HYPH 10_1101-2020_03_27_012757 86 12 ND ND NNP 10_1101-2020_03_27_012757 86 13 4.0 4.0 CD 10_1101-2020_03_27_012757 86 14 International International NNP 10_1101-2020_03_27_012757 86 15 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 86 16 under under IN 10_1101-2020_03_27_012757 86 17 a a DT 10_1101-2020_03_27_012757 86 18 ( ( -LRB- 10_1101-2020_03_27_012757 86 19 which which WDT 10_1101-2020_03_27_012757 86 20 was be VBD 10_1101-2020_03_27_012757 86 21 not not RB 10_1101-2020_03_27_012757 86 22 certified certify VBN 10_1101-2020_03_27_012757 86 23 by by IN 10_1101-2020_03_27_012757 86 24 peer peer NN 10_1101-2020_03_27_012757 86 25 review review NN 10_1101-2020_03_27_012757 86 26 ) ) -RRB- 10_1101-2020_03_27_012757 86 27 is be VBZ 10_1101-2020_03_27_012757 86 28 the the DT 10_1101-2020_03_27_012757 86 29 author author NN 10_1101-2020_03_27_012757 86 30 / / SYM 10_1101-2020_03_27_012757 86 31 funder funder NN 10_1101-2020_03_27_012757 86 32 , , , 10_1101-2020_03_27_012757 86 33 who who WP 10_1101-2020_03_27_012757 86 34 has have VBZ 10_1101-2020_03_27_012757 86 35 granted grant VBN 10_1101-2020_03_27_012757 86 36 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 86 37 a a DT 10_1101-2020_03_27_012757 86 38 license license NN 10_1101-2020_03_27_012757 86 39 to to TO 10_1101-2020_03_27_012757 86 40 display display VB 10_1101-2020_03_27_012757 86 41 the the DT 10_1101-2020_03_27_012757 86 42 preprint preprint NN 10_1101-2020_03_27_012757 86 43 in in IN 10_1101-2020_03_27_012757 86 44 perpetuity perpetuity NN 10_1101-2020_03_27_012757 86 45 . . . 10_1101-2020_03_27_012757 87 1 It -PRON- PRP 10_1101-2020_03_27_012757 87 2 is be VBZ 10_1101-2020_03_27_012757 87 3 made make VBN 10_1101-2020_03_27_012757 87 4 The the DT 10_1101-2020_03_27_012757 87 5 copyright copyright NN 10_1101-2020_03_27_012757 87 6 holder holder NN 10_1101-2020_03_27_012757 87 7 for for IN 10_1101-2020_03_27_012757 87 8 this this DT 10_1101-2020_03_27_012757 87 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 87 10 version version NN 10_1101-2020_03_27_012757 87 11 posted post VBD 10_1101-2020_03_27_012757 87 12 January January NNP 10_1101-2020_03_27_012757 87 13 9 9 CD 10_1101-2020_03_27_012757 87 14 , , , 10_1101-2020_03_27_012757 87 15 2021 2021 CD 10_1101-2020_03_27_012757 87 16 . . . 10_1101-2020_03_27_012757 87 17 ; ; : 10_1101-2020_03_27_012757 87 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 87 19 : : : 10_1101-2020_03_27_012757 87 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 87 21 preprint preprint NN 10_1101-2020_03_27_012757 87 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 87 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 87 24 8 8 CD 10_1101-2020_03_27_012757 87 25 a a DT 10_1101-2020_03_27_012757 87 26 cell cell NN 10_1101-2020_03_27_012757 87 27 was be VBD 10_1101-2020_03_27_012757 87 28 a a DT 10_1101-2020_03_27_012757 87 29 good good JJ 10_1101-2020_03_27_012757 87 30 model model NN 10_1101-2020_03_27_012757 87 31 for for IN 10_1101-2020_03_27_012757 87 32 a a DT 10_1101-2020_03_27_012757 87 33 rarer rare JJR 10_1101-2020_03_27_012757 87 34 subtype subtype NN 10_1101-2020_03_27_012757 87 35 , , , 10_1101-2020_03_27_012757 87 36 then then RB 10_1101-2020_03_27_012757 87 37 it -PRON- PRP 10_1101-2020_03_27_012757 87 38 would would MD 10_1101-2020_03_27_012757 87 39 receive receive VB 10_1101-2020_03_27_012757 87 40 a a DT 10_1101-2020_03_27_012757 87 41 poor poor JJ 10_1101-2020_03_27_012757 87 42 general general JJ 10_1101-2020_03_27_012757 87 43 classification classification NN 10_1101-2020_03_27_012757 87 44 215 215 CD 10_1101-2020_03_27_012757 87 45 but but CC 10_1101-2020_03_27_012757 87 46 a a DT 10_1101-2020_03_27_012757 87 47 high high JJ 10_1101-2020_03_27_012757 87 48 classification classification NN 10_1101-2020_03_27_012757 87 49 for for IN 10_1101-2020_03_27_012757 87 50 the the DT 10_1101-2020_03_27_012757 87 51 subtype subtype NN 10_1101-2020_03_27_012757 87 52 that that WDT 10_1101-2020_03_27_012757 87 53 it -PRON- PRP 10_1101-2020_03_27_012757 87 54 models model VBZ 10_1101-2020_03_27_012757 87 55 well well RB 10_1101-2020_03_27_012757 87 56 . . . 10_1101-2020_03_27_012757 88 1 Therefore therefore RB 10_1101-2020_03_27_012757 88 2 , , , 10_1101-2020_03_27_012757 88 3 we -PRON- PRP 10_1101-2020_03_27_012757 88 4 counted count VBD 10_1101-2020_03_27_012757 88 5 the the DT 10_1101-2020_03_27_012757 88 6 number number NN 10_1101-2020_03_27_012757 88 7 of of IN 10_1101-2020_03_27_012757 88 8 216 216 CD 10_1101-2020_03_27_012757 88 9 lines line NNS 10_1101-2020_03_27_012757 88 10 that that WDT 10_1101-2020_03_27_012757 88 11 fit fit VBP 10_1101-2020_03_27_012757 88 12 this this DT 10_1101-2020_03_27_012757 88 13 pattern pattern NN 10_1101-2020_03_27_012757 88 14 . . . 10_1101-2020_03_27_012757 89 1 We -PRON- PRP 10_1101-2020_03_27_012757 89 2 found find VBD 10_1101-2020_03_27_012757 89 3 that that DT 10_1101-2020_03_27_012757 89 4 of of IN 10_1101-2020_03_27_012757 89 5 the the DT 10_1101-2020_03_27_012757 89 6 188 188 CD 10_1101-2020_03_27_012757 89 7 lines line NNS 10_1101-2020_03_27_012757 89 8 with with IN 10_1101-2020_03_27_012757 89 9 no no DT 10_1101-2020_03_27_012757 89 10 general general JJ 10_1101-2020_03_27_012757 89 11 classification classification NN 10_1101-2020_03_27_012757 89 12 , , , 10_1101-2020_03_27_012757 89 13 25 25 CD 10_1101-2020_03_27_012757 89 14 ( ( -LRB- 10_1101-2020_03_27_012757 89 15 13 13 CD 10_1101-2020_03_27_012757 89 16 % % NN 10_1101-2020_03_27_012757 89 17 ) ) -RRB- 10_1101-2020_03_27_012757 89 18 217 217 CD 10_1101-2020_03_27_012757 89 19 were be VBD 10_1101-2020_03_27_012757 89 20 classified classify VBN 10_1101-2020_03_27_012757 89 21 as as IN 10_1101-2020_03_27_012757 89 22 a a DT 10_1101-2020_03_27_012757 89 23 specific specific JJ 10_1101-2020_03_27_012757 89 24 subtype subtype NN 10_1101-2020_03_27_012757 89 25 , , , 10_1101-2020_03_27_012757 89 26 suggesting suggest VBG 10_1101-2020_03_27_012757 89 27 that that IN 10_1101-2020_03_27_012757 89 28 derivation derivation NN 10_1101-2020_03_27_012757 89 29 from from IN 10_1101-2020_03_27_012757 89 30 rare rare JJ 10_1101-2020_03_27_012757 89 31 subtypes subtype NNS 10_1101-2020_03_27_012757 89 32 is be VBZ 10_1101-2020_03_27_012757 89 33 not not RB 10_1101-2020_03_27_012757 89 34 the the DT 10_1101-2020_03_27_012757 89 35 218 218 CD 10_1101-2020_03_27_012757 89 36 major major JJ 10_1101-2020_03_27_012757 89 37 contributor contributor NN 10_1101-2020_03_27_012757 89 38 to to IN 10_1101-2020_03_27_012757 89 39 the the DT 10_1101-2020_03_27_012757 89 40 poor poor JJ 10_1101-2020_03_27_012757 89 41 overall overall JJ 10_1101-2020_03_27_012757 89 42 fidelity fidelity NN 10_1101-2020_03_27_012757 89 43 of of IN 10_1101-2020_03_27_012757 89 44 CCLs CCLs NNP 10_1101-2020_03_27_012757 89 45 . . . 10_1101-2020_03_27_012757 90 1 219 219 CD 10_1101-2020_03_27_012757 90 2 Another another DT 10_1101-2020_03_27_012757 90 3 potential potential JJ 10_1101-2020_03_27_012757 90 4 contributor contributor NN 10_1101-2020_03_27_012757 90 5 to to IN 10_1101-2020_03_27_012757 90 6 low low JJ 10_1101-2020_03_27_012757 90 7 scoring score VBG 10_1101-2020_03_27_012757 90 8 cell cell NN 10_1101-2020_03_27_012757 90 9 lines line NNS 10_1101-2020_03_27_012757 90 10 is be VBZ 10_1101-2020_03_27_012757 90 11 intra intra JJ 10_1101-2020_03_27_012757 90 12 - - JJ 10_1101-2020_03_27_012757 90 13 tumor tumor JJ 10_1101-2020_03_27_012757 90 14 stromal stromal NN 10_1101-2020_03_27_012757 90 15 and and CC 10_1101-2020_03_27_012757 90 16 immune immune JJ 10_1101-2020_03_27_012757 90 17 220 220 CD 10_1101-2020_03_27_012757 90 18 cell cell NN 10_1101-2020_03_27_012757 90 19 impurity impurity NN 10_1101-2020_03_27_012757 90 20 in in IN 10_1101-2020_03_27_012757 90 21 the the DT 10_1101-2020_03_27_012757 90 22 training training NN 10_1101-2020_03_27_012757 90 23 data datum NNS 10_1101-2020_03_27_012757 90 24 . . . 10_1101-2020_03_27_012757 91 1 If if IN 10_1101-2020_03_27_012757 91 2 impurity impurity NN 10_1101-2020_03_27_012757 91 3 were be VBD 10_1101-2020_03_27_012757 91 4 a a DT 10_1101-2020_03_27_012757 91 5 confounder confounder NN 10_1101-2020_03_27_012757 91 6 of of IN 10_1101-2020_03_27_012757 91 7 CCN CCN NNP 10_1101-2020_03_27_012757 91 8 scoring score VBG 10_1101-2020_03_27_012757 91 9 , , , 10_1101-2020_03_27_012757 91 10 then then RB 10_1101-2020_03_27_012757 91 11 we -PRON- PRP 10_1101-2020_03_27_012757 91 12 would would MD 10_1101-2020_03_27_012757 91 13 221 221 CD 10_1101-2020_03_27_012757 91 14 expect expect VB 10_1101-2020_03_27_012757 91 15 a a DT 10_1101-2020_03_27_012757 91 16 strong strong JJ 10_1101-2020_03_27_012757 91 17 positive positive JJ 10_1101-2020_03_27_012757 91 18 correlation correlation NN 10_1101-2020_03_27_012757 91 19 between between IN 10_1101-2020_03_27_012757 91 20 mean mean JJ 10_1101-2020_03_27_012757 91 21 purity purity NN 10_1101-2020_03_27_012757 91 22 and and CC 10_1101-2020_03_27_012757 91 23 mean mean VB 10_1101-2020_03_27_012757 91 24 CCN CCN NNP 10_1101-2020_03_27_012757 91 25 classification classification NN 10_1101-2020_03_27_012757 91 26 scores score NNS 10_1101-2020_03_27_012757 91 27 of of IN 10_1101-2020_03_27_012757 91 28 222 222 CD 10_1101-2020_03_27_012757 91 29 CCLs ccl NNS 10_1101-2020_03_27_012757 91 30 per per IN 10_1101-2020_03_27_012757 91 31 general general JJ 10_1101-2020_03_27_012757 91 32 tumor tumor NN 10_1101-2020_03_27_012757 91 33 type type NN 10_1101-2020_03_27_012757 91 34 . . . 10_1101-2020_03_27_012757 92 1 However however RB 10_1101-2020_03_27_012757 92 2 , , , 10_1101-2020_03_27_012757 92 3 the the DT 10_1101-2020_03_27_012757 92 4 Pearson Pearson NNP 10_1101-2020_03_27_012757 92 5 correlation correlation NN 10_1101-2020_03_27_012757 92 6 coefficient coefficient NN 10_1101-2020_03_27_012757 92 7 between between IN 10_1101-2020_03_27_012757 92 8 the the DT 10_1101-2020_03_27_012757 92 9 mean mean JJ 10_1101-2020_03_27_012757 92 10 223 223 CD 10_1101-2020_03_27_012757 92 11 purity purity NN 10_1101-2020_03_27_012757 92 12 of of IN 10_1101-2020_03_27_012757 92 13 general general JJ 10_1101-2020_03_27_012757 92 14 tumor tumor NN 10_1101-2020_03_27_012757 92 15 type type NN 10_1101-2020_03_27_012757 92 16 and and CC 10_1101-2020_03_27_012757 92 17 mean mean VB 10_1101-2020_03_27_012757 92 18 CCN CCN NNP 10_1101-2020_03_27_012757 92 19 classification classification NN 10_1101-2020_03_27_012757 92 20 scores score NNS 10_1101-2020_03_27_012757 92 21 of of IN 10_1101-2020_03_27_012757 92 22 CCLs ccl NNS 10_1101-2020_03_27_012757 92 23 in in IN 10_1101-2020_03_27_012757 92 24 the the DT 10_1101-2020_03_27_012757 92 25 corresponding corresponding JJ 10_1101-2020_03_27_012757 92 26 224 224 CD 10_1101-2020_03_27_012757 92 27 general general JJ 10_1101-2020_03_27_012757 92 28 tumor tumor NN 10_1101-2020_03_27_012757 92 29 type type NN 10_1101-2020_03_27_012757 92 30 was be VBD 10_1101-2020_03_27_012757 92 31 low low JJ 10_1101-2020_03_27_012757 92 32 ( ( -LRB- 10_1101-2020_03_27_012757 92 33 0.14 0.14 CD 10_1101-2020_03_27_012757 92 34 ) ) -RRB- 10_1101-2020_03_27_012757 92 35 , , , 10_1101-2020_03_27_012757 92 36 suggesting suggest VBG 10_1101-2020_03_27_012757 92 37 that that IN 10_1101-2020_03_27_012757 92 38 tumor tumor NN 10_1101-2020_03_27_012757 92 39 purity purity NN 10_1101-2020_03_27_012757 92 40 is be VBZ 10_1101-2020_03_27_012757 92 41 not not RB 10_1101-2020_03_27_012757 92 42 a a DT 10_1101-2020_03_27_012757 92 43 major major JJ 10_1101-2020_03_27_012757 92 44 contributor contributor NN 10_1101-2020_03_27_012757 92 45 to to IN 10_1101-2020_03_27_012757 92 46 the the DT 10_1101-2020_03_27_012757 92 47 225 225 CD 10_1101-2020_03_27_012757 92 48 low low JJ 10_1101-2020_03_27_012757 92 49 CCN CCN NNP 10_1101-2020_03_27_012757 92 50 scores score NNS 10_1101-2020_03_27_012757 92 51 across across IN 10_1101-2020_03_27_012757 92 52 CCLs ccl NNS 10_1101-2020_03_27_012757 92 53 ( ( -LRB- 10_1101-2020_03_27_012757 92 54 Supp Supp NNP 10_1101-2020_03_27_012757 92 55 Fig Fig NNP 10_1101-2020_03_27_012757 92 56 2E 2e NN 10_1101-2020_03_27_012757 92 57 ) ) -RRB- 10_1101-2020_03_27_012757 92 58 . . . 10_1101-2020_03_27_012757 93 1 226 226 CD 10_1101-2020_03_27_012757 93 2 227 227 CD 10_1101-2020_03_27_012757 93 3 Comparison Comparison NNP 10_1101-2020_03_27_012757 93 4 of of IN 10_1101-2020_03_27_012757 93 5 SKCM SKCM NNP 10_1101-2020_03_27_012757 93 6 and and CC 10_1101-2020_03_27_012757 93 7 GBM GBM NNP 10_1101-2020_03_27_012757 93 8 CCLs CCLs NNPS 10_1101-2020_03_27_012757 93 9 to to IN 10_1101-2020_03_27_012757 93 10 scRNA scrna CD 10_1101-2020_03_27_012757 93 11 - - HYPH 10_1101-2020_03_27_012757 93 12 seq seq NN 10_1101-2020_03_27_012757 93 13 228 228 CD 10_1101-2020_03_27_012757 93 14 To to TO 10_1101-2020_03_27_012757 93 15 more more RBR 10_1101-2020_03_27_012757 93 16 directly directly RB 10_1101-2020_03_27_012757 93 17 assess assess VB 10_1101-2020_03_27_012757 93 18 the the DT 10_1101-2020_03_27_012757 93 19 impact impact NN 10_1101-2020_03_27_012757 93 20 of of IN 10_1101-2020_03_27_012757 93 21 intra intra JJ 10_1101-2020_03_27_012757 93 22 - - JJ 10_1101-2020_03_27_012757 93 23 tumor tumor JJ 10_1101-2020_03_27_012757 93 24 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 93 25 in in IN 10_1101-2020_03_27_012757 93 26 the the DT 10_1101-2020_03_27_012757 93 27 training training NN 10_1101-2020_03_27_012757 93 28 data datum NNS 10_1101-2020_03_27_012757 93 29 on on IN 10_1101-2020_03_27_012757 93 30 229 229 CD 10_1101-2020_03_27_012757 93 31 evaluating evaluate VBG 10_1101-2020_03_27_012757 93 32 cell cell NN 10_1101-2020_03_27_012757 93 33 lines line NNS 10_1101-2020_03_27_012757 93 34 , , , 10_1101-2020_03_27_012757 93 35 we -PRON- PRP 10_1101-2020_03_27_012757 93 36 constructed construct VBD 10_1101-2020_03_27_012757 93 37 a a DT 10_1101-2020_03_27_012757 93 38 classifier classifier NN 10_1101-2020_03_27_012757 93 39 using use VBG 10_1101-2020_03_27_012757 93 40 cell cell NN 10_1101-2020_03_27_012757 93 41 types type NNS 10_1101-2020_03_27_012757 93 42 found find VBN 10_1101-2020_03_27_012757 93 43 in in IN 10_1101-2020_03_27_012757 93 44 human human JJ 10_1101-2020_03_27_012757 93 45 melanoma melanoma NN 10_1101-2020_03_27_012757 93 46 and and CC 10_1101-2020_03_27_012757 93 47 230 230 CD 10_1101-2020_03_27_012757 93 48 glioblastoma glioblastoma NN 10_1101-2020_03_27_012757 93 49 scRNA scrna NN 10_1101-2020_03_27_012757 93 50 - - HYPH 10_1101-2020_03_27_012757 93 51 seq seq NN 10_1101-2020_03_27_012757 93 52 data40,41 data40,41 NNP 10_1101-2020_03_27_012757 93 53 . . . 10_1101-2020_03_27_012757 94 1 Previously previously RB 10_1101-2020_03_27_012757 94 2 , , , 10_1101-2020_03_27_012757 94 3 we -PRON- PRP 10_1101-2020_03_27_012757 94 4 have have VBP 10_1101-2020_03_27_012757 94 5 demonstrated demonstrate VBN 10_1101-2020_03_27_012757 94 6 the the DT 10_1101-2020_03_27_012757 94 7 feasibility feasibility NN 10_1101-2020_03_27_012757 94 8 of of IN 10_1101-2020_03_27_012757 94 9 using use VBG 10_1101-2020_03_27_012757 94 10 our -PRON- PRP$ 10_1101-2020_03_27_012757 94 11 231 231 CD 10_1101-2020_03_27_012757 94 12 classification classification NN 10_1101-2020_03_27_012757 94 13 approach approach NN 10_1101-2020_03_27_012757 94 14 on on IN 10_1101-2020_03_27_012757 94 15 scRNA scRNA NNP 10_1101-2020_03_27_012757 94 16 - - HYPH 10_1101-2020_03_27_012757 94 17 seq seq NN 10_1101-2020_03_27_012757 94 18 data23 data23 NN 10_1101-2020_03_27_012757 94 19 . . . 10_1101-2020_03_27_012757 95 1 Our -PRON- PRP$ 10_1101-2020_03_27_012757 95 2 scRNA scrna JJ 10_1101-2020_03_27_012757 95 3 - - HYPH 10_1101-2020_03_27_012757 95 4 seq seq NN 10_1101-2020_03_27_012757 95 5 classifier classifier NN 10_1101-2020_03_27_012757 95 6 achieved achieve VBD 10_1101-2020_03_27_012757 95 7 a a DT 10_1101-2020_03_27_012757 95 8 high high JJ 10_1101-2020_03_27_012757 95 9 232 232 CD 10_1101-2020_03_27_012757 95 10 average average JJ 10_1101-2020_03_27_012757 95 11 AUPRC AUPRC NNS 10_1101-2020_03_27_012757 95 12 ( ( -LRB- 10_1101-2020_03_27_012757 95 13 0.95 0.95 CD 10_1101-2020_03_27_012757 95 14 ) ) -RRB- 10_1101-2020_03_27_012757 95 15 when when WRB 10_1101-2020_03_27_012757 95 16 applied apply VBN 10_1101-2020_03_27_012757 95 17 to to IN 10_1101-2020_03_27_012757 95 18 held hold VBN 10_1101-2020_03_27_012757 95 19 - - HYPH 10_1101-2020_03_27_012757 95 20 out out RP 10_1101-2020_03_27_012757 95 21 data datum NNS 10_1101-2020_03_27_012757 95 22 and and CC 10_1101-2020_03_27_012757 95 23 high high JJ 10_1101-2020_03_27_012757 95 24 mean mean JJ 10_1101-2020_03_27_012757 95 25 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 95 26 ( ( -LRB- 10_1101-2020_03_27_012757 95 27 0.99 0.99 CD 10_1101-2020_03_27_012757 95 28 ) ) -RRB- 10_1101-2020_03_27_012757 95 29 when when WRB 10_1101-2020_03_27_012757 95 30 233 233 CD 10_1101-2020_03_27_012757 95 31 applied apply VBD 10_1101-2020_03_27_012757 95 32 to to IN 10_1101-2020_03_27_012757 95 33 few few JJ 10_1101-2020_03_27_012757 95 34 purified purify VBN 10_1101-2020_03_27_012757 95 35 bulk bulk JJ 10_1101-2020_03_27_012757 95 36 testing testing NN 10_1101-2020_03_27_012757 95 37 samples sample NNS 10_1101-2020_03_27_012757 95 38 ( ( -LRB- 10_1101-2020_03_27_012757 95 39 Supp Supp NNP 10_1101-2020_03_27_012757 95 40 Fig Fig NNP 10_1101-2020_03_27_012757 95 41 3A 3A NNP 10_1101-2020_03_27_012757 95 42 - - HYPH 10_1101-2020_03_27_012757 95 43 B B NNP 10_1101-2020_03_27_012757 95 44 ) ) -RRB- 10_1101-2020_03_27_012757 95 45 . . . 10_1101-2020_03_27_012757 96 1 Comparing compare VBG 10_1101-2020_03_27_012757 96 2 the the DT 10_1101-2020_03_27_012757 96 3 CCN CCN NNP 10_1101-2020_03_27_012757 96 4 score score NN 10_1101-2020_03_27_012757 96 5 from from IN 10_1101-2020_03_27_012757 96 6 234 234 CD 10_1101-2020_03_27_012757 96 7 bulk bulk NN 10_1101-2020_03_27_012757 96 8 RNA RNA NNP 10_1101-2020_03_27_012757 96 9 - - HYPH 10_1101-2020_03_27_012757 96 10 seq seq NN 10_1101-2020_03_27_012757 96 11 general general JJ 10_1101-2020_03_27_012757 96 12 classifier classifier NN 10_1101-2020_03_27_012757 96 13 and and CC 10_1101-2020_03_27_012757 96 14 scRNA scRNA NNP 10_1101-2020_03_27_012757 96 15 - - HYPH 10_1101-2020_03_27_012757 96 16 seq seq NN 10_1101-2020_03_27_012757 96 17 classifier classifier NN 10_1101-2020_03_27_012757 96 18 , , , 10_1101-2020_03_27_012757 96 19 we -PRON- PRP 10_1101-2020_03_27_012757 96 20 observed observe VBD 10_1101-2020_03_27_012757 96 21 a a DT 10_1101-2020_03_27_012757 96 22 high high JJ 10_1101-2020_03_27_012757 96 23 level level NN 10_1101-2020_03_27_012757 96 24 of of IN 10_1101-2020_03_27_012757 96 25 235 235 CD 10_1101-2020_03_27_012757 96 26 correlation correlation NN 10_1101-2020_03_27_012757 96 27 ( ( -LRB- 10_1101-2020_03_27_012757 96 28 Pearson Pearson NNP 10_1101-2020_03_27_012757 96 29 correlation correlation NN 10_1101-2020_03_27_012757 96 30 of of IN 10_1101-2020_03_27_012757 96 31 0.89 0.89 CD 10_1101-2020_03_27_012757 96 32 ) ) -RRB- 10_1101-2020_03_27_012757 96 33 between between IN 10_1101-2020_03_27_012757 96 34 the the DT 10_1101-2020_03_27_012757 96 35 SKCM SKCM NNP 10_1101-2020_03_27_012757 96 36 CCN ccn NN 10_1101-2020_03_27_012757 96 37 classification classification NN 10_1101-2020_03_27_012757 96 38 scores score NNS 10_1101-2020_03_27_012757 96 39 and and CC 10_1101-2020_03_27_012757 96 40 236 236 CD 10_1101-2020_03_27_012757 96 41 scRNA scrna CD 10_1101-2020_03_27_012757 96 42 - - HYPH 10_1101-2020_03_27_012757 96 43 seq seq NN 10_1101-2020_03_27_012757 96 44 SKCM SKCM NNP 10_1101-2020_03_27_012757 96 45 malignant malignant JJ 10_1101-2020_03_27_012757 96 46 CCN CCN NNP 10_1101-2020_03_27_012757 96 47 classification classification NN 10_1101-2020_03_27_012757 96 48 scores score NNS 10_1101-2020_03_27_012757 96 49 for for IN 10_1101-2020_03_27_012757 96 50 SKCM SKCM NNP 10_1101-2020_03_27_012757 96 51 cell cell NN 10_1101-2020_03_27_012757 96 52 lines line NNS 10_1101-2020_03_27_012757 96 53 ( ( -LRB- 10_1101-2020_03_27_012757 96 54 Fig fig NN 10_1101-2020_03_27_012757 96 55 2C 2c NN 10_1101-2020_03_27_012757 96 56 , , , 10_1101-2020_03_27_012757 96 57 Supp Supp NNP 10_1101-2020_03_27_012757 96 58 Fig Fig NNP 10_1101-2020_03_27_012757 96 59 237 237 CD 10_1101-2020_03_27_012757 96 60 3C 3c NN 10_1101-2020_03_27_012757 96 61 ) ) -RRB- 10_1101-2020_03_27_012757 96 62 . . . 10_1101-2020_03_27_012757 97 1 Of of IN 10_1101-2020_03_27_012757 97 2 the the DT 10_1101-2020_03_27_012757 97 3 41 41 CD 10_1101-2020_03_27_012757 97 4 SKCM SKCM NNP 10_1101-2020_03_27_012757 97 5 cell cell NN 10_1101-2020_03_27_012757 97 6 lines line NNS 10_1101-2020_03_27_012757 97 7 that that WDT 10_1101-2020_03_27_012757 97 8 were be VBD 10_1101-2020_03_27_012757 97 9 classified classify VBN 10_1101-2020_03_27_012757 97 10 as as IN 10_1101-2020_03_27_012757 97 11 SKCM SKCM NNP 10_1101-2020_03_27_012757 97 12 by by IN 10_1101-2020_03_27_012757 97 13 the the DT 10_1101-2020_03_27_012757 97 14 bulk bulk NN 10_1101-2020_03_27_012757 97 15 classifier classifier NN 10_1101-2020_03_27_012757 97 16 , , , 10_1101-2020_03_27_012757 97 17 37 37 CD 10_1101-2020_03_27_012757 97 18 were be VBD 10_1101-2020_03_27_012757 97 19 also also RB 10_1101-2020_03_27_012757 97 20 238 238 CD 10_1101-2020_03_27_012757 97 21 classified classify VBN 10_1101-2020_03_27_012757 97 22 as as IN 10_1101-2020_03_27_012757 97 23 SKCM SKCM NNP 10_1101-2020_03_27_012757 97 24 malignant malignant JJ 10_1101-2020_03_27_012757 97 25 cells cell NNS 10_1101-2020_03_27_012757 97 26 by by IN 10_1101-2020_03_27_012757 97 27 the the DT 10_1101-2020_03_27_012757 97 28 scRNA scRNA NNP 10_1101-2020_03_27_012757 97 29 - - HYPH 10_1101-2020_03_27_012757 97 30 seq seq NN 10_1101-2020_03_27_012757 97 31 classifier classifier NN 10_1101-2020_03_27_012757 97 32 . . . 10_1101-2020_03_27_012757 98 1 Interestingly interestingly RB 10_1101-2020_03_27_012757 98 2 , , , 10_1101-2020_03_27_012757 98 3 we -PRON- PRP 10_1101-2020_03_27_012757 98 4 also also RB 10_1101-2020_03_27_012757 98 5 observed observe VBD 10_1101-2020_03_27_012757 98 6 239 239 CD 10_1101-2020_03_27_012757 98 7 a a DT 10_1101-2020_03_27_012757 98 8 high high JJ 10_1101-2020_03_27_012757 98 9 correlation correlation NN 10_1101-2020_03_27_012757 98 10 between between IN 10_1101-2020_03_27_012757 98 11 the the DT 10_1101-2020_03_27_012757 98 12 SARC SARC NNP 10_1101-2020_03_27_012757 98 13 CCN CCN NNP 10_1101-2020_03_27_012757 98 14 classification classification NN 10_1101-2020_03_27_012757 98 15 score score NN 10_1101-2020_03_27_012757 98 16 and and CC 10_1101-2020_03_27_012757 98 17 scRNA scrna NN 10_1101-2020_03_27_012757 98 18 - - HYPH 10_1101-2020_03_27_012757 98 19 seq seq NN 10_1101-2020_03_27_012757 98 20 cancer cancer NN 10_1101-2020_03_27_012757 98 21 240 240 CD 10_1101-2020_03_27_012757 98 22 .CC .CC : 10_1101-2020_03_27_012757 98 23 - - : 10_1101-2020_03_27_012757 98 24 BY by IN 10_1101-2020_03_27_012757 98 25 - - HYPH 10_1101-2020_03_27_012757 98 26 NC NC NNP 10_1101-2020_03_27_012757 98 27 - - HYPH 10_1101-2020_03_27_012757 98 28 ND ND NNP 10_1101-2020_03_27_012757 98 29 4.0 4.0 CD 10_1101-2020_03_27_012757 98 30 International International NNP 10_1101-2020_03_27_012757 98 31 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 98 32 under under IN 10_1101-2020_03_27_012757 98 33 a a DT 10_1101-2020_03_27_012757 98 34 ( ( -LRB- 10_1101-2020_03_27_012757 98 35 which which WDT 10_1101-2020_03_27_012757 98 36 was be VBD 10_1101-2020_03_27_012757 98 37 not not RB 10_1101-2020_03_27_012757 98 38 certified certify VBN 10_1101-2020_03_27_012757 98 39 by by IN 10_1101-2020_03_27_012757 98 40 peer peer NN 10_1101-2020_03_27_012757 98 41 review review NN 10_1101-2020_03_27_012757 98 42 ) ) -RRB- 10_1101-2020_03_27_012757 98 43 is be VBZ 10_1101-2020_03_27_012757 98 44 the the DT 10_1101-2020_03_27_012757 98 45 author author NN 10_1101-2020_03_27_012757 98 46 / / SYM 10_1101-2020_03_27_012757 98 47 funder funder NN 10_1101-2020_03_27_012757 98 48 , , , 10_1101-2020_03_27_012757 98 49 who who WP 10_1101-2020_03_27_012757 98 50 has have VBZ 10_1101-2020_03_27_012757 98 51 granted grant VBN 10_1101-2020_03_27_012757 98 52 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 98 53 a a DT 10_1101-2020_03_27_012757 98 54 license license NN 10_1101-2020_03_27_012757 98 55 to to TO 10_1101-2020_03_27_012757 98 56 display display VB 10_1101-2020_03_27_012757 98 57 the the DT 10_1101-2020_03_27_012757 98 58 preprint preprint NN 10_1101-2020_03_27_012757 98 59 in in IN 10_1101-2020_03_27_012757 98 60 perpetuity perpetuity NN 10_1101-2020_03_27_012757 98 61 . . . 10_1101-2020_03_27_012757 99 1 It -PRON- PRP 10_1101-2020_03_27_012757 99 2 is be VBZ 10_1101-2020_03_27_012757 99 3 made make VBN 10_1101-2020_03_27_012757 99 4 The the DT 10_1101-2020_03_27_012757 99 5 copyright copyright NN 10_1101-2020_03_27_012757 99 6 holder holder NN 10_1101-2020_03_27_012757 99 7 for for IN 10_1101-2020_03_27_012757 99 8 this this DT 10_1101-2020_03_27_012757 99 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 99 10 version version NN 10_1101-2020_03_27_012757 99 11 posted post VBD 10_1101-2020_03_27_012757 99 12 January January NNP 10_1101-2020_03_27_012757 99 13 9 9 CD 10_1101-2020_03_27_012757 99 14 , , , 10_1101-2020_03_27_012757 99 15 2021 2021 CD 10_1101-2020_03_27_012757 99 16 . . . 10_1101-2020_03_27_012757 99 17 ; ; : 10_1101-2020_03_27_012757 99 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 99 19 : : : 10_1101-2020_03_27_012757 99 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 99 21 preprint preprint NN 10_1101-2020_03_27_012757 99 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 99 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 99 24 9 9 CD 10_1101-2020_03_27_012757 99 25 associated associate VBN 10_1101-2020_03_27_012757 99 26 fibroblast fibroblast NN 10_1101-2020_03_27_012757 99 27 ( ( -LRB- 10_1101-2020_03_27_012757 99 28 CAF CAF NNP 10_1101-2020_03_27_012757 99 29 ) ) -RRB- 10_1101-2020_03_27_012757 99 30 CCN CCN NNP 10_1101-2020_03_27_012757 99 31 classification classification NN 10_1101-2020_03_27_012757 99 32 scores score NNS 10_1101-2020_03_27_012757 99 33 ( ( -LRB- 10_1101-2020_03_27_012757 99 34 Pearson Pearson NNP 10_1101-2020_03_27_012757 99 35 correlation correlation NN 10_1101-2020_03_27_012757 99 36 of of IN 10_1101-2020_03_27_012757 99 37 0.92 0.92 CD 10_1101-2020_03_27_012757 99 38 ) ) -RRB- 10_1101-2020_03_27_012757 99 39 . . . 10_1101-2020_03_27_012757 100 1 Six six CD 10_1101-2020_03_27_012757 100 2 of of IN 10_1101-2020_03_27_012757 100 3 the the DT 10_1101-2020_03_27_012757 100 4 241 241 CD 10_1101-2020_03_27_012757 100 5 seven seven CD 10_1101-2020_03_27_012757 100 6 SKCM SKCM NNP 10_1101-2020_03_27_012757 100 7 cell cell NN 10_1101-2020_03_27_012757 100 8 lines line NNS 10_1101-2020_03_27_012757 100 9 that that WDT 10_1101-2020_03_27_012757 100 10 had have VBD 10_1101-2020_03_27_012757 100 11 been be VBN 10_1101-2020_03_27_012757 100 12 classified classify VBN 10_1101-2020_03_27_012757 100 13 as as IN 10_1101-2020_03_27_012757 100 14 exclusively exclusively RB 10_1101-2020_03_27_012757 100 15 SARC SARC VBN 10_1101-2020_03_27_012757 100 16 by by IN 10_1101-2020_03_27_012757 100 17 CCN CCN NNP 10_1101-2020_03_27_012757 100 18 were be VBD 10_1101-2020_03_27_012757 100 19 classified classify VBN 10_1101-2020_03_27_012757 100 20 as as IN 10_1101-2020_03_27_012757 100 21 242 242 CD 10_1101-2020_03_27_012757 100 22 CAF CAF NNP 10_1101-2020_03_27_012757 100 23 by by IN 10_1101-2020_03_27_012757 100 24 the the DT 10_1101-2020_03_27_012757 100 25 scRNA scrna CD 10_1101-2020_03_27_012757 100 26 - - HYPH 10_1101-2020_03_27_012757 100 27 seq seq NN 10_1101-2020_03_27_012757 100 28 classifier classifier NN 10_1101-2020_03_27_012757 100 29 ( ( -LRB- 10_1101-2020_03_27_012757 100 30 Fig fig NN 10_1101-2020_03_27_012757 100 31 2D 2D VBD 10_1101-2020_03_27_012757 100 32 , , , 10_1101-2020_03_27_012757 100 33 Supp Supp NNP 10_1101-2020_03_27_012757 100 34 Fig Fig NNP 10_1101-2020_03_27_012757 100 35 3C 3c NN 10_1101-2020_03_27_012757 100 36 ) ) -RRB- 10_1101-2020_03_27_012757 100 37 , , , 10_1101-2020_03_27_012757 100 38 which which WDT 10_1101-2020_03_27_012757 100 39 suggests suggest VBZ 10_1101-2020_03_27_012757 100 40 the the DT 10_1101-2020_03_27_012757 100 41 possibility possibility NN 10_1101-2020_03_27_012757 100 42 that that IN 10_1101-2020_03_27_012757 100 43 243 243 CD 10_1101-2020_03_27_012757 100 44 these these DT 10_1101-2020_03_27_012757 100 45 cell cell NN 10_1101-2020_03_27_012757 100 46 lines line NNS 10_1101-2020_03_27_012757 100 47 were be VBD 10_1101-2020_03_27_012757 100 48 derived derive VBN 10_1101-2020_03_27_012757 100 49 from from IN 10_1101-2020_03_27_012757 100 50 CAF CAF NNP 10_1101-2020_03_27_012757 100 51 or or CC 10_1101-2020_03_27_012757 100 52 other other JJ 10_1101-2020_03_27_012757 100 53 mesenchymal mesenchymal JJ 10_1101-2020_03_27_012757 100 54 populations population NNS 10_1101-2020_03_27_012757 100 55 , , , 10_1101-2020_03_27_012757 100 56 or or CC 10_1101-2020_03_27_012757 100 57 that that IN 10_1101-2020_03_27_012757 100 58 they -PRON- PRP 10_1101-2020_03_27_012757 100 59 have have VBP 10_1101-2020_03_27_012757 100 60 244 244 CD 10_1101-2020_03_27_012757 100 61 acquired acquire VBN 10_1101-2020_03_27_012757 100 62 a a DT 10_1101-2020_03_27_012757 100 63 mesenchymal mesenchymal JJ 10_1101-2020_03_27_012757 100 64 character character NN 10_1101-2020_03_27_012757 100 65 through through IN 10_1101-2020_03_27_012757 100 66 their -PRON- PRP$ 10_1101-2020_03_27_012757 100 67 derivation derivation NN 10_1101-2020_03_27_012757 100 68 . . . 10_1101-2020_03_27_012757 101 1 The the DT 10_1101-2020_03_27_012757 101 2 high high JJ 10_1101-2020_03_27_012757 101 3 level level NN 10_1101-2020_03_27_012757 101 4 of of IN 10_1101-2020_03_27_012757 101 5 agreement agreement NN 10_1101-2020_03_27_012757 101 6 245 245 CD 10_1101-2020_03_27_012757 101 7 between between IN 10_1101-2020_03_27_012757 101 8 scRNA scrna CD 10_1101-2020_03_27_012757 101 9 - - HYPH 10_1101-2020_03_27_012757 101 10 seq seq NN 10_1101-2020_03_27_012757 101 11 and and CC 10_1101-2020_03_27_012757 101 12 bulk bulk NNP 10_1101-2020_03_27_012757 101 13 RNA RNA NNP 10_1101-2020_03_27_012757 101 14 - - HYPH 10_1101-2020_03_27_012757 101 15 seq seq NN 10_1101-2020_03_27_012757 101 16 classification classification NN 10_1101-2020_03_27_012757 101 17 results result NNS 10_1101-2020_03_27_012757 101 18 shows show VBZ 10_1101-2020_03_27_012757 101 19 that that IN 10_1101-2020_03_27_012757 101 20 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 101 21 in in IN 10_1101-2020_03_27_012757 101 22 the the DT 10_1101-2020_03_27_012757 101 23 246 246 CD 10_1101-2020_03_27_012757 101 24 training training NN 10_1101-2020_03_27_012757 101 25 data datum NNS 10_1101-2020_03_27_012757 101 26 of of IN 10_1101-2020_03_27_012757 101 27 general general JJ 10_1101-2020_03_27_012757 101 28 CCN CCN NNP 10_1101-2020_03_27_012757 101 29 classifier classifier NN 10_1101-2020_03_27_012757 101 30 has have VBZ 10_1101-2020_03_27_012757 101 31 little little JJ 10_1101-2020_03_27_012757 101 32 impact impact NN 10_1101-2020_03_27_012757 101 33 in in IN 10_1101-2020_03_27_012757 101 34 the the DT 10_1101-2020_03_27_012757 101 35 classification classification NN 10_1101-2020_03_27_012757 101 36 of of IN 10_1101-2020_03_27_012757 101 37 SKCM SKCM NNP 10_1101-2020_03_27_012757 101 38 cell cell NN 10_1101-2020_03_27_012757 101 39 lines line NNS 10_1101-2020_03_27_012757 101 40 . . . 10_1101-2020_03_27_012757 102 1 247 247 CD 10_1101-2020_03_27_012757 102 2 In in IN 10_1101-2020_03_27_012757 102 3 contrast contrast NN 10_1101-2020_03_27_012757 102 4 , , , 10_1101-2020_03_27_012757 102 5 we -PRON- PRP 10_1101-2020_03_27_012757 102 6 observed observe VBD 10_1101-2020_03_27_012757 102 7 a a DT 10_1101-2020_03_27_012757 102 8 weaker weak JJR 10_1101-2020_03_27_012757 102 9 correlation correlation NN 10_1101-2020_03_27_012757 102 10 between between IN 10_1101-2020_03_27_012757 102 11 GBM GBM NNP 10_1101-2020_03_27_012757 102 12 CCN CCN NNP 10_1101-2020_03_27_012757 102 13 classification classification NN 10_1101-2020_03_27_012757 102 14 scores score NNS 10_1101-2020_03_27_012757 102 15 248 248 CD 10_1101-2020_03_27_012757 102 16 and and CC 10_1101-2020_03_27_012757 102 17 scRNA scrna CD 10_1101-2020_03_27_012757 102 18 - - HYPH 10_1101-2020_03_27_012757 102 19 seq seq NN 10_1101-2020_03_27_012757 102 20 GBM GBM NNP 10_1101-2020_03_27_012757 102 21 neoplastic neoplastic JJ 10_1101-2020_03_27_012757 102 22 CCN CCN NNP 10_1101-2020_03_27_012757 102 23 classification classification NN 10_1101-2020_03_27_012757 102 24 scores score NNS 10_1101-2020_03_27_012757 102 25 ( ( -LRB- 10_1101-2020_03_27_012757 102 26 Pearson Pearson NNP 10_1101-2020_03_27_012757 102 27 correlation correlation NN 10_1101-2020_03_27_012757 102 28 of of IN 10_1101-2020_03_27_012757 102 29 0.72 0.72 CD 10_1101-2020_03_27_012757 102 30 ) ) -RRB- 10_1101-2020_03_27_012757 102 31 for for IN 10_1101-2020_03_27_012757 102 32 249 249 CD 10_1101-2020_03_27_012757 102 33 GBM GBM NNP 10_1101-2020_03_27_012757 102 34 cell cell NN 10_1101-2020_03_27_012757 102 35 lines line NNS 10_1101-2020_03_27_012757 102 36 ( ( -LRB- 10_1101-2020_03_27_012757 102 37 Fig fig NN 10_1101-2020_03_27_012757 102 38 2E 2e NN 10_1101-2020_03_27_012757 102 39 , , , 10_1101-2020_03_27_012757 102 40 Supp Supp NNP 10_1101-2020_03_27_012757 102 41 Fig Fig NNP 10_1101-2020_03_27_012757 102 42 3D 3d NN 10_1101-2020_03_27_012757 102 43 ) ) -RRB- 10_1101-2020_03_27_012757 102 44 . . . 10_1101-2020_03_27_012757 103 1 Of of IN 10_1101-2020_03_27_012757 103 2 the the DT 10_1101-2020_03_27_012757 103 3 31 31 CD 10_1101-2020_03_27_012757 103 4 GBM GBM NNP 10_1101-2020_03_27_012757 103 5 lines line NNS 10_1101-2020_03_27_012757 103 6 that that WDT 10_1101-2020_03_27_012757 103 7 were be VBD 10_1101-2020_03_27_012757 103 8 not not RB 10_1101-2020_03_27_012757 103 9 classified classify VBN 10_1101-2020_03_27_012757 103 10 as as IN 10_1101-2020_03_27_012757 103 11 GBM GBM NNP 10_1101-2020_03_27_012757 103 12 250 250 CD 10_1101-2020_03_27_012757 103 13 with with IN 10_1101-2020_03_27_012757 103 14 CCN CCN NNP 10_1101-2020_03_27_012757 103 15 , , , 10_1101-2020_03_27_012757 103 16 25 25 CD 10_1101-2020_03_27_012757 103 17 were be VBD 10_1101-2020_03_27_012757 103 18 classified classify VBN 10_1101-2020_03_27_012757 103 19 as as IN 10_1101-2020_03_27_012757 103 20 GBM GBM NNP 10_1101-2020_03_27_012757 103 21 neoplastic neoplastic JJ 10_1101-2020_03_27_012757 103 22 cells cell NNS 10_1101-2020_03_27_012757 103 23 with with IN 10_1101-2020_03_27_012757 103 24 the the DT 10_1101-2020_03_27_012757 103 25 scRNA scrna CD 10_1101-2020_03_27_012757 103 26 - - HYPH 10_1101-2020_03_27_012757 103 27 seq seq NN 10_1101-2020_03_27_012757 103 28 classifier classifier NN 10_1101-2020_03_27_012757 103 29 . . . 10_1101-2020_03_27_012757 104 1 Among among IN 10_1101-2020_03_27_012757 104 2 the the DT 10_1101-2020_03_27_012757 104 3 251 251 CD 10_1101-2020_03_27_012757 104 4 22 22 CD 10_1101-2020_03_27_012757 104 5 GBM GBM NNP 10_1101-2020_03_27_012757 104 6 lines line NNS 10_1101-2020_03_27_012757 104 7 that that WDT 10_1101-2020_03_27_012757 104 8 were be VBD 10_1101-2020_03_27_012757 104 9 classified classify VBN 10_1101-2020_03_27_012757 104 10 as as IN 10_1101-2020_03_27_012757 104 11 SARC sarc NN 10_1101-2020_03_27_012757 104 12 with with IN 10_1101-2020_03_27_012757 104 13 CCN CCN NNP 10_1101-2020_03_27_012757 104 14 , , , 10_1101-2020_03_27_012757 104 15 15 15 CD 10_1101-2020_03_27_012757 104 16 cell cell NN 10_1101-2020_03_27_012757 104 17 lines line NNS 10_1101-2020_03_27_012757 104 18 were be VBD 10_1101-2020_03_27_012757 104 19 classified classify VBN 10_1101-2020_03_27_012757 104 20 as as IN 10_1101-2020_03_27_012757 104 21 CAF CAF NNP 10_1101-2020_03_27_012757 104 22 ( ( -LRB- 10_1101-2020_03_27_012757 104 23 Fig Fig NNP 10_1101-2020_03_27_012757 104 24 252 252 CD 10_1101-2020_03_27_012757 104 25 2F 2f CD 10_1101-2020_03_27_012757 104 26 ) ) -RRB- 10_1101-2020_03_27_012757 104 27 , , , 10_1101-2020_03_27_012757 104 28 10 10 CD 10_1101-2020_03_27_012757 104 29 which which WDT 10_1101-2020_03_27_012757 104 30 were be VBD 10_1101-2020_03_27_012757 104 31 classified classify VBN 10_1101-2020_03_27_012757 104 32 as as IN 10_1101-2020_03_27_012757 104 33 both both CC 10_1101-2020_03_27_012757 104 34 GBM GBM NNP 10_1101-2020_03_27_012757 104 35 neoplastic neoplastic NN 10_1101-2020_03_27_012757 104 36 and and CC 10_1101-2020_03_27_012757 104 37 CAF CAF NNP 10_1101-2020_03_27_012757 104 38 in in IN 10_1101-2020_03_27_012757 104 39 the the DT 10_1101-2020_03_27_012757 104 40 scRNA scrna JJ 10_1101-2020_03_27_012757 104 41 - - HYPH 10_1101-2020_03_27_012757 104 42 seq seq NN 10_1101-2020_03_27_012757 104 43 classifier classifier NN 10_1101-2020_03_27_012757 104 44 . . . 10_1101-2020_03_27_012757 105 1 253 253 CD 10_1101-2020_03_27_012757 105 2 Similar similar JJ 10_1101-2020_03_27_012757 105 3 to to IN 10_1101-2020_03_27_012757 105 4 the the DT 10_1101-2020_03_27_012757 105 5 situation situation NN 10_1101-2020_03_27_012757 105 6 with with IN 10_1101-2020_03_27_012757 105 7 SKCM SKCM NNP 10_1101-2020_03_27_012757 105 8 lines line NNS 10_1101-2020_03_27_012757 105 9 that that WDT 10_1101-2020_03_27_012757 105 10 classify classify VBP 10_1101-2020_03_27_012757 105 11 as as IN 10_1101-2020_03_27_012757 105 12 CAF CAF NNP 10_1101-2020_03_27_012757 105 13 , , , 10_1101-2020_03_27_012757 105 14 this this DT 10_1101-2020_03_27_012757 105 15 result result NN 10_1101-2020_03_27_012757 105 16 is be VBZ 10_1101-2020_03_27_012757 105 17 consistent consistent JJ 10_1101-2020_03_27_012757 105 18 with with IN 10_1101-2020_03_27_012757 105 19 the the DT 10_1101-2020_03_27_012757 105 20 254 254 CD 10_1101-2020_03_27_012757 105 21 possibility possibility NN 10_1101-2020_03_27_012757 105 22 that that IN 10_1101-2020_03_27_012757 105 23 some some DT 10_1101-2020_03_27_012757 105 24 GBM GBM NNP 10_1101-2020_03_27_012757 105 25 lines line NNS 10_1101-2020_03_27_012757 105 26 classified classify VBD 10_1101-2020_03_27_012757 105 27 as as IN 10_1101-2020_03_27_012757 105 28 SARC SARC VBN 10_1101-2020_03_27_012757 105 29 by by IN 10_1101-2020_03_27_012757 105 30 CCN CCN NNP 10_1101-2020_03_27_012757 105 31 could could MD 10_1101-2020_03_27_012757 105 32 be be VB 10_1101-2020_03_27_012757 105 33 derived derive VBN 10_1101-2020_03_27_012757 105 34 from from IN 10_1101-2020_03_27_012757 105 35 255 255 CD 10_1101-2020_03_27_012757 105 36 mesenchymal mesenchymal JJ 10_1101-2020_03_27_012757 105 37 subtypes subtype NNS 10_1101-2020_03_27_012757 105 38 exhibiting exhibit VBG 10_1101-2020_03_27_012757 105 39 both both CC 10_1101-2020_03_27_012757 105 40 strong strong JJ 10_1101-2020_03_27_012757 105 41 mesenchymal mesenchymal JJ 10_1101-2020_03_27_012757 105 42 signatures signature NNS 10_1101-2020_03_27_012757 105 43 and and CC 10_1101-2020_03_27_012757 105 44 glioblastoma glioblastoma NNP 10_1101-2020_03_27_012757 105 45 256 256 CD 10_1101-2020_03_27_012757 105 46 signatures signature NNS 10_1101-2020_03_27_012757 105 47 or or CC 10_1101-2020_03_27_012757 105 48 that that IN 10_1101-2020_03_27_012757 105 49 they -PRON- PRP 10_1101-2020_03_27_012757 105 50 have have VBP 10_1101-2020_03_27_012757 105 51 acquired acquire VBN 10_1101-2020_03_27_012757 105 52 a a DT 10_1101-2020_03_27_012757 105 53 mesenchymal mesenchymal JJ 10_1101-2020_03_27_012757 105 54 character character NN 10_1101-2020_03_27_012757 105 55 through through IN 10_1101-2020_03_27_012757 105 56 their -PRON- PRP$ 10_1101-2020_03_27_012757 105 57 derivation derivation NN 10_1101-2020_03_27_012757 105 58 . . . 10_1101-2020_03_27_012757 106 1 The the DT 10_1101-2020_03_27_012757 106 2 257 257 CD 10_1101-2020_03_27_012757 106 3 lower low JJR 10_1101-2020_03_27_012757 106 4 level level NN 10_1101-2020_03_27_012757 106 5 of of IN 10_1101-2020_03_27_012757 106 6 agreement agreement NN 10_1101-2020_03_27_012757 106 7 between between IN 10_1101-2020_03_27_012757 106 8 scRNA scRNA NNP 10_1101-2020_03_27_012757 106 9 - - HYPH 10_1101-2020_03_27_012757 106 10 seq seq NN 10_1101-2020_03_27_012757 106 11 and and CC 10_1101-2020_03_27_012757 106 12 bulk bulk NNP 10_1101-2020_03_27_012757 106 13 RNA RNA NNP 10_1101-2020_03_27_012757 106 14 - - HYPH 10_1101-2020_03_27_012757 106 15 seq seq NN 10_1101-2020_03_27_012757 106 16 classification classification NN 10_1101-2020_03_27_012757 106 17 results result NNS 10_1101-2020_03_27_012757 106 18 for for IN 10_1101-2020_03_27_012757 106 19 GBM GBM NNP 10_1101-2020_03_27_012757 106 20 258 258 CD 10_1101-2020_03_27_012757 106 21 models model NNS 10_1101-2020_03_27_012757 106 22 suggests suggest VBZ 10_1101-2020_03_27_012757 106 23 that that IN 10_1101-2020_03_27_012757 106 24 the the DT 10_1101-2020_03_27_012757 106 25 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 106 26 of of IN 10_1101-2020_03_27_012757 106 27 glioblastomas42 glioblastomas42 NNP 10_1101-2020_03_27_012757 106 28 can can MD 10_1101-2020_03_27_012757 106 29 impact impact VB 10_1101-2020_03_27_012757 106 30 the the DT 10_1101-2020_03_27_012757 106 31 classification classification NN 10_1101-2020_03_27_012757 106 32 of of IN 10_1101-2020_03_27_012757 106 33 GBM GBM NNP 10_1101-2020_03_27_012757 106 34 259 259 CD 10_1101-2020_03_27_012757 106 35 cell cell NN 10_1101-2020_03_27_012757 106 36 lines line NNS 10_1101-2020_03_27_012757 106 37 , , , 10_1101-2020_03_27_012757 106 38 and and CC 10_1101-2020_03_27_012757 106 39 that that IN 10_1101-2020_03_27_012757 106 40 the the DT 10_1101-2020_03_27_012757 106 41 use use NN 10_1101-2020_03_27_012757 106 42 of of IN 10_1101-2020_03_27_012757 106 43 scRNA scrna JJ 10_1101-2020_03_27_012757 106 44 - - HYPH 10_1101-2020_03_27_012757 106 45 seq seq NN 10_1101-2020_03_27_012757 106 46 classifier classifier NN 10_1101-2020_03_27_012757 106 47 can can MD 10_1101-2020_03_27_012757 106 48 resolve resolve VB 10_1101-2020_03_27_012757 106 49 this this DT 10_1101-2020_03_27_012757 106 50 deficiency deficiency NN 10_1101-2020_03_27_012757 106 51 . . . 10_1101-2020_03_27_012757 107 1 260 260 CD 10_1101-2020_03_27_012757 107 2 261 261 CD 10_1101-2020_03_27_012757 107 3 Immunofluorescence immunofluorescence JJ 10_1101-2020_03_27_012757 107 4 confirmation confirmation NN 10_1101-2020_03_27_012757 107 5 of of IN 10_1101-2020_03_27_012757 107 6 CCN CCN NNP 10_1101-2020_03_27_012757 107 7 predictions prediction NNS 10_1101-2020_03_27_012757 107 8 262 262 CD 10_1101-2020_03_27_012757 107 9 To to TO 10_1101-2020_03_27_012757 107 10 experimentally experimentally RB 10_1101-2020_03_27_012757 107 11 explore explore VB 10_1101-2020_03_27_012757 107 12 some some DT 10_1101-2020_03_27_012757 107 13 of of IN 10_1101-2020_03_27_012757 107 14 our -PRON- PRP$ 10_1101-2020_03_27_012757 107 15 computational computational JJ 10_1101-2020_03_27_012757 107 16 analyses analysis NNS 10_1101-2020_03_27_012757 107 17 , , , 10_1101-2020_03_27_012757 107 18 we -PRON- PRP 10_1101-2020_03_27_012757 107 19 performed perform VBD 10_1101-2020_03_27_012757 107 20 263 263 CD 10_1101-2020_03_27_012757 107 21 immunofluorescence immunofluorescence NN 10_1101-2020_03_27_012757 107 22 on on IN 10_1101-2020_03_27_012757 107 23 three three CD 10_1101-2020_03_27_012757 107 24 cell cell NN 10_1101-2020_03_27_012757 107 25 lines line NNS 10_1101-2020_03_27_012757 107 26 that that WDT 10_1101-2020_03_27_012757 107 27 were be VBD 10_1101-2020_03_27_012757 107 28 not not RB 10_1101-2020_03_27_012757 107 29 classified classify VBN 10_1101-2020_03_27_012757 107 30 as as IN 10_1101-2020_03_27_012757 107 31 their -PRON- PRP$ 10_1101-2020_03_27_012757 107 32 labelled label VBN 10_1101-2020_03_27_012757 107 33 categories category NNS 10_1101-2020_03_27_012757 107 34 : : : 10_1101-2020_03_27_012757 107 35 the the DT 10_1101-2020_03_27_012757 107 36 264 264 CD 10_1101-2020_03_27_012757 107 37 ovarian ovarian JJ 10_1101-2020_03_27_012757 107 38 cancer cancer NN 10_1101-2020_03_27_012757 107 39 line line NN 10_1101-2020_03_27_012757 107 40 SK SK NNP 10_1101-2020_03_27_012757 107 41 - - HYPH 10_1101-2020_03_27_012757 107 42 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 107 43 had have VBD 10_1101-2020_03_27_012757 107 44 a a DT 10_1101-2020_03_27_012757 107 45 high high JJ 10_1101-2020_03_27_012757 107 46 UCEC ucec NN 10_1101-2020_03_27_012757 107 47 CCN CCN NNP 10_1101-2020_03_27_012757 107 48 score score NN 10_1101-2020_03_27_012757 107 49 ( ( -LRB- 10_1101-2020_03_27_012757 107 50 0.246 0.246 CD 10_1101-2020_03_27_012757 107 51 ) ) -RRB- 10_1101-2020_03_27_012757 107 52 , , , 10_1101-2020_03_27_012757 107 53 the the DT 10_1101-2020_03_27_012757 107 54 ovarian ovarian JJ 10_1101-2020_03_27_012757 107 55 cancer cancer NN 10_1101-2020_03_27_012757 107 56 line line NN 10_1101-2020_03_27_012757 107 57 265 265 CD 10_1101-2020_03_27_012757 107 58 A2780 A2780 NNP 10_1101-2020_03_27_012757 107 59 had have VBD 10_1101-2020_03_27_012757 107 60 a a DT 10_1101-2020_03_27_012757 107 61 high high JJ 10_1101-2020_03_27_012757 107 62 Testicular Testicular NNP 10_1101-2020_03_27_012757 107 63 Germ Germ NNP 10_1101-2020_03_27_012757 107 64 Cell Cell NNP 10_1101-2020_03_27_012757 107 65 Tumors Tumors NNPS 10_1101-2020_03_27_012757 107 66 ( ( -LRB- 10_1101-2020_03_27_012757 107 67 TGCT TGCT NNP 10_1101-2020_03_27_012757 107 68 ) ) -RRB- 10_1101-2020_03_27_012757 107 69 CCN CCN NNP 10_1101-2020_03_27_012757 107 70 score score NN 10_1101-2020_03_27_012757 107 71 ( ( -LRB- 10_1101-2020_03_27_012757 107 72 0.327 0.327 CD 10_1101-2020_03_27_012757 107 73 ) ) -RRB- 10_1101-2020_03_27_012757 107 74 , , , 10_1101-2020_03_27_012757 107 75 and and CC 10_1101-2020_03_27_012757 107 76 the the DT 10_1101-2020_03_27_012757 107 77 prostate prostate NN 10_1101-2020_03_27_012757 107 78 266 266 CD 10_1101-2020_03_27_012757 107 79 .CC .CC , 10_1101-2020_03_27_012757 107 80 - - : 10_1101-2020_03_27_012757 107 81 BY by IN 10_1101-2020_03_27_012757 107 82 - - HYPH 10_1101-2020_03_27_012757 107 83 NC NC NNP 10_1101-2020_03_27_012757 107 84 - - HYPH 10_1101-2020_03_27_012757 107 85 ND ND NNP 10_1101-2020_03_27_012757 107 86 4.0 4.0 CD 10_1101-2020_03_27_012757 107 87 International International NNP 10_1101-2020_03_27_012757 107 88 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 107 89 under under IN 10_1101-2020_03_27_012757 107 90 a a DT 10_1101-2020_03_27_012757 107 91 ( ( -LRB- 10_1101-2020_03_27_012757 107 92 which which WDT 10_1101-2020_03_27_012757 107 93 was be VBD 10_1101-2020_03_27_012757 107 94 not not RB 10_1101-2020_03_27_012757 107 95 certified certify VBN 10_1101-2020_03_27_012757 107 96 by by IN 10_1101-2020_03_27_012757 107 97 peer peer NN 10_1101-2020_03_27_012757 107 98 review review NN 10_1101-2020_03_27_012757 107 99 ) ) -RRB- 10_1101-2020_03_27_012757 107 100 is be VBZ 10_1101-2020_03_27_012757 107 101 the the DT 10_1101-2020_03_27_012757 107 102 author author NN 10_1101-2020_03_27_012757 107 103 / / SYM 10_1101-2020_03_27_012757 107 104 funder funder NN 10_1101-2020_03_27_012757 107 105 , , , 10_1101-2020_03_27_012757 107 106 who who WP 10_1101-2020_03_27_012757 107 107 has have VBZ 10_1101-2020_03_27_012757 107 108 granted grant VBN 10_1101-2020_03_27_012757 107 109 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 107 110 a a DT 10_1101-2020_03_27_012757 107 111 license license NN 10_1101-2020_03_27_012757 107 112 to to TO 10_1101-2020_03_27_012757 107 113 display display VB 10_1101-2020_03_27_012757 107 114 the the DT 10_1101-2020_03_27_012757 107 115 preprint preprint NN 10_1101-2020_03_27_012757 107 116 in in IN 10_1101-2020_03_27_012757 107 117 perpetuity perpetuity NN 10_1101-2020_03_27_012757 107 118 . . . 10_1101-2020_03_27_012757 108 1 It -PRON- PRP 10_1101-2020_03_27_012757 108 2 is be VBZ 10_1101-2020_03_27_012757 108 3 made make VBN 10_1101-2020_03_27_012757 108 4 The the DT 10_1101-2020_03_27_012757 108 5 copyright copyright NN 10_1101-2020_03_27_012757 108 6 holder holder NN 10_1101-2020_03_27_012757 108 7 for for IN 10_1101-2020_03_27_012757 108 8 this this DT 10_1101-2020_03_27_012757 108 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 108 10 version version NN 10_1101-2020_03_27_012757 108 11 posted post VBD 10_1101-2020_03_27_012757 108 12 January January NNP 10_1101-2020_03_27_012757 108 13 9 9 CD 10_1101-2020_03_27_012757 108 14 , , , 10_1101-2020_03_27_012757 108 15 2021 2021 CD 10_1101-2020_03_27_012757 108 16 . . . 10_1101-2020_03_27_012757 108 17 ; ; : 10_1101-2020_03_27_012757 108 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 108 19 : : : 10_1101-2020_03_27_012757 108 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 108 21 preprint preprint NN 10_1101-2020_03_27_012757 108 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 108 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 108 24 10 10 CD 10_1101-2020_03_27_012757 108 25 cancer cancer NN 10_1101-2020_03_27_012757 108 26 line line NN 10_1101-2020_03_27_012757 108 27 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 108 28 had have VBD 10_1101-2020_03_27_012757 108 29 a a DT 10_1101-2020_03_27_012757 108 30 high high JJ 10_1101-2020_03_27_012757 108 31 bladder bladder NN 10_1101-2020_03_27_012757 108 32 cancer cancer NN 10_1101-2020_03_27_012757 108 33 ( ( -LRB- 10_1101-2020_03_27_012757 108 34 BLCA BLCA NNP 10_1101-2020_03_27_012757 108 35 ) ) -RRB- 10_1101-2020_03_27_012757 108 36 score score NN 10_1101-2020_03_27_012757 108 37 ( ( -LRB- 10_1101-2020_03_27_012757 108 38 0.307 0.307 CD 10_1101-2020_03_27_012757 108 39 ) ) -RRB- 10_1101-2020_03_27_012757 108 40 ( ( -LRB- 10_1101-2020_03_27_012757 108 41 Supp Supp NNP 10_1101-2020_03_27_012757 108 42 Tab Tab NNP 10_1101-2020_03_27_012757 108 43 1 1 CD 10_1101-2020_03_27_012757 108 44 ) ) -RRB- 10_1101-2020_03_27_012757 108 45 . . . 10_1101-2020_03_27_012757 109 1 We -PRON- PRP 10_1101-2020_03_27_012757 109 2 reasoned reason VBD 10_1101-2020_03_27_012757 109 3 267 267 CD 10_1101-2020_03_27_012757 109 4 that that IN 10_1101-2020_03_27_012757 109 5 if if IN 10_1101-2020_03_27_012757 109 6 SK SK NNP 10_1101-2020_03_27_012757 109 7 - - HYPH 10_1101-2020_03_27_012757 109 8 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 109 9 , , , 10_1101-2020_03_27_012757 109 10 A2780 A2780 NNP 10_1101-2020_03_27_012757 109 11 and and CC 10_1101-2020_03_27_012757 109 12 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 109 13 were be VBD 10_1101-2020_03_27_012757 109 14 classified classify VBN 10_1101-2020_03_27_012757 109 15 most most RBS 10_1101-2020_03_27_012757 109 16 strongly strongly RB 10_1101-2020_03_27_012757 109 17 as as IN 10_1101-2020_03_27_012757 109 18 UCEC UCEC NNP 10_1101-2020_03_27_012757 109 19 , , , 10_1101-2020_03_27_012757 109 20 TGCT TGCT NNP 10_1101-2020_03_27_012757 109 21 and and CC 10_1101-2020_03_27_012757 109 22 BLCA BLCA NNP 10_1101-2020_03_27_012757 109 23 , , , 10_1101-2020_03_27_012757 109 24 268 268 CD 10_1101-2020_03_27_012757 109 25 respectively respectively RB 10_1101-2020_03_27_012757 109 26 , , , 10_1101-2020_03_27_012757 109 27 then then RB 10_1101-2020_03_27_012757 109 28 they -PRON- PRP 10_1101-2020_03_27_012757 109 29 would would MD 10_1101-2020_03_27_012757 109 30 express express VB 10_1101-2020_03_27_012757 109 31 proteins protein NNS 10_1101-2020_03_27_012757 109 32 that that WDT 10_1101-2020_03_27_012757 109 33 are be VBP 10_1101-2020_03_27_012757 109 34 indicative indicative JJ 10_1101-2020_03_27_012757 109 35 of of IN 10_1101-2020_03_27_012757 109 36 these these DT 10_1101-2020_03_27_012757 109 37 cancer cancer NN 10_1101-2020_03_27_012757 109 38 types type NNS 10_1101-2020_03_27_012757 109 39 . . . 10_1101-2020_03_27_012757 110 1 269 269 CD 10_1101-2020_03_27_012757 110 2 First first RB 10_1101-2020_03_27_012757 110 3 , , , 10_1101-2020_03_27_012757 110 4 we -PRON- PRP 10_1101-2020_03_27_012757 110 5 measured measure VBD 10_1101-2020_03_27_012757 110 6 the the DT 10_1101-2020_03_27_012757 110 7 expression expression NN 10_1101-2020_03_27_012757 110 8 of of IN 10_1101-2020_03_27_012757 110 9 the the DT 10_1101-2020_03_27_012757 110 10 uterine uterine NN 10_1101-2020_03_27_012757 110 11 - - HYPH 10_1101-2020_03_27_012757 110 12 associated associated JJ 10_1101-2020_03_27_012757 110 13 transcription transcription NN 10_1101-2020_03_27_012757 110 14 factor factor NN 10_1101-2020_03_27_012757 110 15 270 270 CD 10_1101-2020_03_27_012757 110 16 HOXB643,44 HOXB643,44 NNS 10_1101-2020_03_27_012757 110 17 , , , 10_1101-2020_03_27_012757 110 18 and and CC 10_1101-2020_03_27_012757 110 19 the the DT 10_1101-2020_03_27_012757 110 20 UCEC UCEC NNP 10_1101-2020_03_27_012757 110 21 serous serous JJ 10_1101-2020_03_27_012757 110 22 ovarian ovarian JJ 10_1101-2020_03_27_012757 110 23 tumor tumor NN 10_1101-2020_03_27_012757 110 24 biomarker biomarker NN 10_1101-2020_03_27_012757 110 25 WT145 WT145 NNP 10_1101-2020_03_27_012757 110 26 in in IN 10_1101-2020_03_27_012757 110 27 SK SK NNP 10_1101-2020_03_27_012757 110 28 - - HYPH 10_1101-2020_03_27_012757 110 29 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 110 30 , , , 10_1101-2020_03_27_012757 110 31 in in IN 10_1101-2020_03_27_012757 110 32 the the DT 10_1101-2020_03_27_012757 110 33 OV OV NNP 10_1101-2020_03_27_012757 110 34 cell cell NN 10_1101-2020_03_27_012757 110 35 271 271 CD 10_1101-2020_03_27_012757 110 36 line line NN 10_1101-2020_03_27_012757 110 37 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 110 38 , , , 10_1101-2020_03_27_012757 110 39 and and CC 10_1101-2020_03_27_012757 110 40 in in IN 10_1101-2020_03_27_012757 110 41 the the DT 10_1101-2020_03_27_012757 110 42 UCEC UCEC NNP 10_1101-2020_03_27_012757 110 43 cell cell NN 10_1101-2020_03_27_012757 110 44 line line NN 10_1101-2020_03_27_012757 110 45 HEC-59 hec-59 RB 10_1101-2020_03_27_012757 110 46 . . . 10_1101-2020_03_27_012757 111 1 We -PRON- PRP 10_1101-2020_03_27_012757 111 2 chose choose VBD 10_1101-2020_03_27_012757 111 3 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 111 4 as as IN 10_1101-2020_03_27_012757 111 5 our -PRON- PRP$ 10_1101-2020_03_27_012757 111 6 positive positive JJ 10_1101-2020_03_27_012757 111 7 control control NN 10_1101-2020_03_27_012757 111 8 for for IN 10_1101-2020_03_27_012757 111 9 OV OV NNP 10_1101-2020_03_27_012757 111 10 272 272 CD 10_1101-2020_03_27_012757 111 11 biomarker biomarker NN 10_1101-2020_03_27_012757 111 12 expression expression NN 10_1101-2020_03_27_012757 111 13 because because IN 10_1101-2020_03_27_012757 111 14 it -PRON- PRP 10_1101-2020_03_27_012757 111 15 was be VBD 10_1101-2020_03_27_012757 111 16 determined determine VBN 10_1101-2020_03_27_012757 111 17 by by IN 10_1101-2020_03_27_012757 111 18 our -PRON- PRP$ 10_1101-2020_03_27_012757 111 19 analysis analysis NN 10_1101-2020_03_27_012757 111 20 and and CC 10_1101-2020_03_27_012757 111 21 others11,15 others11,15 JJ 10_1101-2020_03_27_012757 111 22 to to TO 10_1101-2020_03_27_012757 111 23 be be VB 10_1101-2020_03_27_012757 111 24 a a DT 10_1101-2020_03_27_012757 111 25 good good JJ 10_1101-2020_03_27_012757 111 26 273 273 CD 10_1101-2020_03_27_012757 111 27 model model NN 10_1101-2020_03_27_012757 111 28 of of IN 10_1101-2020_03_27_012757 111 29 OV OV NNP 10_1101-2020_03_27_012757 111 30 . . . 10_1101-2020_03_27_012757 112 1 Likewise likewise RB 10_1101-2020_03_27_012757 112 2 , , , 10_1101-2020_03_27_012757 112 3 we -PRON- PRP 10_1101-2020_03_27_012757 112 4 chose choose VBD 10_1101-2020_03_27_012757 112 5 HEC-59 hec-59 JJ 10_1101-2020_03_27_012757 112 6 to to TO 10_1101-2020_03_27_012757 112 7 be be VB 10_1101-2020_03_27_012757 112 8 a a DT 10_1101-2020_03_27_012757 112 9 positive positive JJ 10_1101-2020_03_27_012757 112 10 control control NN 10_1101-2020_03_27_012757 112 11 for for IN 10_1101-2020_03_27_012757 112 12 UCEC UCEC NNP 10_1101-2020_03_27_012757 112 13 . . . 10_1101-2020_03_27_012757 113 1 We -PRON- PRP 10_1101-2020_03_27_012757 113 2 found find VBD 10_1101-2020_03_27_012757 113 3 that that IN 10_1101-2020_03_27_012757 113 4 SK-274 SK-274 NNP 10_1101-2020_03_27_012757 113 5 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 113 6 has have VBZ 10_1101-2020_03_27_012757 113 7 a a DT 10_1101-2020_03_27_012757 113 8 small small JJ 10_1101-2020_03_27_012757 113 9 percentage percentage NN 10_1101-2020_03_27_012757 113 10 ( ( -LRB- 10_1101-2020_03_27_012757 113 11 5 5 CD 10_1101-2020_03_27_012757 113 12 % % NN 10_1101-2020_03_27_012757 113 13 ) ) -RRB- 10_1101-2020_03_27_012757 113 14 of of IN 10_1101-2020_03_27_012757 113 15 cells cell NNS 10_1101-2020_03_27_012757 113 16 that that WDT 10_1101-2020_03_27_012757 113 17 expressed express VBD 10_1101-2020_03_27_012757 113 18 the the DT 10_1101-2020_03_27_012757 113 19 uterine uterine NN 10_1101-2020_03_27_012757 113 20 marker marker NN 10_1101-2020_03_27_012757 113 21 HOXB6 HOXB6 NNP 10_1101-2020_03_27_012757 113 22 and and CC 10_1101-2020_03_27_012757 113 23 a a DT 10_1101-2020_03_27_012757 113 24 275 275 CD 10_1101-2020_03_27_012757 113 25 large large JJ 10_1101-2020_03_27_012757 113 26 proportion proportion NN 10_1101-2020_03_27_012757 113 27 ( ( -LRB- 10_1101-2020_03_27_012757 113 28 73 73 CD 10_1101-2020_03_27_012757 113 29 % % NN 10_1101-2020_03_27_012757 113 30 ) ) -RRB- 10_1101-2020_03_27_012757 113 31 of of IN 10_1101-2020_03_27_012757 113 32 cells cell NNS 10_1101-2020_03_27_012757 113 33 that that WDT 10_1101-2020_03_27_012757 113 34 expressed express VBD 10_1101-2020_03_27_012757 113 35 WT1 WT1 NNP 10_1101-2020_03_27_012757 113 36 ( ( -LRB- 10_1101-2020_03_27_012757 113 37 Fig Fig NNP 10_1101-2020_03_27_012757 113 38 3A 3A NNP 10_1101-2020_03_27_012757 113 39 ) ) -RRB- 10_1101-2020_03_27_012757 113 40 . . . 10_1101-2020_03_27_012757 114 1 In in IN 10_1101-2020_03_27_012757 114 2 contrast contrast NN 10_1101-2020_03_27_012757 114 3 , , , 10_1101-2020_03_27_012757 114 4 no no DT 10_1101-2020_03_27_012757 114 5 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 114 6 cells cell NNS 10_1101-2020_03_27_012757 114 7 276 276 CD 10_1101-2020_03_27_012757 114 8 expressed express VBD 10_1101-2020_03_27_012757 114 9 HOXB6 HOXB6 NNS 10_1101-2020_03_27_012757 114 10 , , , 10_1101-2020_03_27_012757 114 11 whereas whereas IN 10_1101-2020_03_27_012757 114 12 85 85 CD 10_1101-2020_03_27_012757 114 13 % % NN 10_1101-2020_03_27_012757 114 14 of of IN 10_1101-2020_03_27_012757 114 15 cells cell NNS 10_1101-2020_03_27_012757 114 16 expressed express VBD 10_1101-2020_03_27_012757 114 17 WT1 WT1 NNP 10_1101-2020_03_27_012757 114 18 . . . 10_1101-2020_03_27_012757 115 1 This this DT 10_1101-2020_03_27_012757 115 2 suggests suggest VBZ 10_1101-2020_03_27_012757 115 3 that that IN 10_1101-2020_03_27_012757 115 4 SK SK NNP 10_1101-2020_03_27_012757 115 5 - - HYPH 10_1101-2020_03_27_012757 115 6 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 115 7 exhibits exhibit VBZ 10_1101-2020_03_27_012757 115 8 277 277 CD 10_1101-2020_03_27_012757 115 9 both both DT 10_1101-2020_03_27_012757 115 10 biomarkers biomarker NNS 10_1101-2020_03_27_012757 115 11 of of IN 10_1101-2020_03_27_012757 115 12 ovarian ovarian JJ 10_1101-2020_03_27_012757 115 13 tumor tumor NN 10_1101-2020_03_27_012757 115 14 and and CC 10_1101-2020_03_27_012757 115 15 uterine uterine JJ 10_1101-2020_03_27_012757 115 16 tissue tissue NN 10_1101-2020_03_27_012757 115 17 . . . 10_1101-2020_03_27_012757 116 1 From from IN 10_1101-2020_03_27_012757 116 2 our -PRON- PRP$ 10_1101-2020_03_27_012757 116 3 computational computational JJ 10_1101-2020_03_27_012757 116 4 analysis analysis NN 10_1101-2020_03_27_012757 116 5 and and CC 10_1101-2020_03_27_012757 116 6 278 278 CD 10_1101-2020_03_27_012757 116 7 experimental experimental JJ 10_1101-2020_03_27_012757 116 8 validation validation NN 10_1101-2020_03_27_012757 116 9 , , , 10_1101-2020_03_27_012757 116 10 SK SK NNP 10_1101-2020_03_27_012757 116 11 - - HYPH 10_1101-2020_03_27_012757 116 12 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 116 13 is be VBZ 10_1101-2020_03_27_012757 116 14 most most RBS 10_1101-2020_03_27_012757 116 15 likely likely RB 10_1101-2020_03_27_012757 116 16 an an DT 10_1101-2020_03_27_012757 116 17 endometrioid endometrioid NN 10_1101-2020_03_27_012757 116 18 subtype subtype NN 10_1101-2020_03_27_012757 116 19 of of IN 10_1101-2020_03_27_012757 116 20 ovarian ovarian JJ 10_1101-2020_03_27_012757 116 21 cancer cancer NN 10_1101-2020_03_27_012757 116 22 . . . 10_1101-2020_03_27_012757 117 1 This this DT 10_1101-2020_03_27_012757 117 2 279 279 CD 10_1101-2020_03_27_012757 117 3 result result NN 10_1101-2020_03_27_012757 117 4 is be VBZ 10_1101-2020_03_27_012757 117 5 also also RB 10_1101-2020_03_27_012757 117 6 consistent consistent JJ 10_1101-2020_03_27_012757 117 7 with with IN 10_1101-2020_03_27_012757 117 8 prior prior JJ 10_1101-2020_03_27_012757 117 9 classification classification NN 10_1101-2020_03_27_012757 117 10 of of IN 10_1101-2020_03_27_012757 117 11 SK SK NNP 10_1101-2020_03_27_012757 117 12 - - HYPH 10_1101-2020_03_27_012757 117 13 OV-346 OV-346 NNP 10_1101-2020_03_27_012757 117 14 , , , 10_1101-2020_03_27_012757 117 15 and and CC 10_1101-2020_03_27_012757 117 16 the the DT 10_1101-2020_03_27_012757 117 17 fact fact NN 10_1101-2020_03_27_012757 117 18 that that IN 10_1101-2020_03_27_012757 117 19 SK SK NNP 10_1101-2020_03_27_012757 117 20 - - HYPH 10_1101-2020_03_27_012757 117 21 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 117 22 lacks lack VBZ 10_1101-2020_03_27_012757 117 23 280 280 CD 10_1101-2020_03_27_012757 117 24 p53 p53 NN 10_1101-2020_03_27_012757 117 25 mutations mutation NNS 10_1101-2020_03_27_012757 117 26 , , , 10_1101-2020_03_27_012757 117 27 which which WDT 10_1101-2020_03_27_012757 117 28 is be VBZ 10_1101-2020_03_27_012757 117 29 prevalent prevalent JJ 10_1101-2020_03_27_012757 117 30 in in IN 10_1101-2020_03_27_012757 117 31 high high JJ 10_1101-2020_03_27_012757 117 32 - - HYPH 10_1101-2020_03_27_012757 117 33 grade grade NN 10_1101-2020_03_27_012757 117 34 serous serous JJ 10_1101-2020_03_27_012757 117 35 ovarian ovarian JJ 10_1101-2020_03_27_012757 117 36 cancer47 cancer47 NNP 10_1101-2020_03_27_012757 117 37 , , , 10_1101-2020_03_27_012757 117 38 and and CC 10_1101-2020_03_27_012757 117 39 it -PRON- PRP 10_1101-2020_03_27_012757 117 40 harbors harbor VBZ 10_1101-2020_03_27_012757 117 41 an an DT 10_1101-2020_03_27_012757 117 42 281 281 CD 10_1101-2020_03_27_012757 117 43 endometrioid endometrioid NN 10_1101-2020_03_27_012757 117 44 - - HYPH 10_1101-2020_03_27_012757 117 45 associated associate VBN 10_1101-2020_03_27_012757 117 46 mutation mutation NN 10_1101-2020_03_27_012757 117 47 in in IN 10_1101-2020_03_27_012757 117 48 ARID1A11,46,48 ARID1A11,46,48 NNP 10_1101-2020_03_27_012757 117 49 . . . 10_1101-2020_03_27_012757 118 1 Next next RB 10_1101-2020_03_27_012757 118 2 , , , 10_1101-2020_03_27_012757 118 3 we -PRON- PRP 10_1101-2020_03_27_012757 118 4 measured measure VBD 10_1101-2020_03_27_012757 118 5 the the DT 10_1101-2020_03_27_012757 118 6 expression expression NN 10_1101-2020_03_27_012757 118 7 of of IN 10_1101-2020_03_27_012757 118 8 282 282 CD 10_1101-2020_03_27_012757 118 9 markers marker NNS 10_1101-2020_03_27_012757 118 10 of of IN 10_1101-2020_03_27_012757 118 11 OV OV NNP 10_1101-2020_03_27_012757 118 12 and and CC 10_1101-2020_03_27_012757 118 13 germ germ NNP 10_1101-2020_03_27_012757 118 14 cell cell NN 10_1101-2020_03_27_012757 118 15 cancers cancer NNS 10_1101-2020_03_27_012757 118 16 ( ( -LRB- 10_1101-2020_03_27_012757 118 17 LIN28A49 LIN28A49 NNP 10_1101-2020_03_27_012757 118 18 ) ) -RRB- 10_1101-2020_03_27_012757 118 19 in in IN 10_1101-2020_03_27_012757 118 20 the the DT 10_1101-2020_03_27_012757 118 21 OV OV NNP 10_1101-2020_03_27_012757 118 22 - - HYPH 10_1101-2020_03_27_012757 118 23 annotated annotate VBN 10_1101-2020_03_27_012757 118 24 cell cell NN 10_1101-2020_03_27_012757 118 25 line line NN 10_1101-2020_03_27_012757 118 26 A2780 A2780 NNP 10_1101-2020_03_27_012757 118 27 , , , 10_1101-2020_03_27_012757 118 28 which which WDT 10_1101-2020_03_27_012757 118 29 283 283 CD 10_1101-2020_03_27_012757 118 30 received receive VBD 10_1101-2020_03_27_012757 118 31 a a DT 10_1101-2020_03_27_012757 118 32 high high JJ 10_1101-2020_03_27_012757 118 33 TCGT TCGT NNP 10_1101-2020_03_27_012757 118 34 CCN ccn NN 10_1101-2020_03_27_012757 118 35 score score VBP 10_1101-2020_03_27_012757 118 36 . . . 10_1101-2020_03_27_012757 119 1 We -PRON- PRP 10_1101-2020_03_27_012757 119 2 found find VBD 10_1101-2020_03_27_012757 119 3 that that IN 10_1101-2020_03_27_012757 119 4 54 54 CD 10_1101-2020_03_27_012757 119 5 % % NN 10_1101-2020_03_27_012757 119 6 of of IN 10_1101-2020_03_27_012757 119 7 A2780 A2780 NNP 10_1101-2020_03_27_012757 119 8 cells cell NNS 10_1101-2020_03_27_012757 119 9 expressed express VBD 10_1101-2020_03_27_012757 119 10 LIN28A lin28a IN 10_1101-2020_03_27_012757 119 11 284 284 CD 10_1101-2020_03_27_012757 119 12 whereas whereas IN 10_1101-2020_03_27_012757 119 13 it -PRON- PRP 10_1101-2020_03_27_012757 119 14 was be VBD 10_1101-2020_03_27_012757 119 15 not not RB 10_1101-2020_03_27_012757 119 16 detected detect VBN 10_1101-2020_03_27_012757 119 17 in in IN 10_1101-2020_03_27_012757 119 18 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 119 19 ( ( -LRB- 10_1101-2020_03_27_012757 119 20 Fig Fig NNP 10_1101-2020_03_27_012757 119 21 3B 3b NN 10_1101-2020_03_27_012757 119 22 ) ) -RRB- 10_1101-2020_03_27_012757 119 23 . . . 10_1101-2020_03_27_012757 120 1 The the DT 10_1101-2020_03_27_012757 120 2 OV OV NNP 10_1101-2020_03_27_012757 120 3 marker marker NN 10_1101-2020_03_27_012757 120 4 WT1 WT1 NNP 10_1101-2020_03_27_012757 120 5 was be VBD 10_1101-2020_03_27_012757 120 6 also also RB 10_1101-2020_03_27_012757 120 7 expressed express VBN 10_1101-2020_03_27_012757 120 8 in in IN 10_1101-2020_03_27_012757 120 9 285 285 CD 10_1101-2020_03_27_012757 120 10 fewer few JJR 10_1101-2020_03_27_012757 120 11 A2780 A2780 NNP 10_1101-2020_03_27_012757 120 12 cells cell NNS 10_1101-2020_03_27_012757 120 13 as as IN 10_1101-2020_03_27_012757 120 14 compared compare VBN 10_1101-2020_03_27_012757 120 15 to to IN 10_1101-2020_03_27_012757 120 16 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 120 17 ( ( -LRB- 10_1101-2020_03_27_012757 120 18 48 48 CD 10_1101-2020_03_27_012757 120 19 % % NN 10_1101-2020_03_27_012757 120 20 vs vs IN 10_1101-2020_03_27_012757 120 21 85 85 CD 10_1101-2020_03_27_012757 120 22 % % NN 10_1101-2020_03_27_012757 120 23 ) ) -RRB- 10_1101-2020_03_27_012757 120 24 , , , 10_1101-2020_03_27_012757 120 25 which which WDT 10_1101-2020_03_27_012757 120 26 suggests suggest VBZ 10_1101-2020_03_27_012757 120 27 that that IN 10_1101-2020_03_27_012757 120 28 A2780 A2780 NNP 10_1101-2020_03_27_012757 120 29 could could MD 10_1101-2020_03_27_012757 120 30 be be VB 10_1101-2020_03_27_012757 120 31 a a DT 10_1101-2020_03_27_012757 120 32 286 286 CD 10_1101-2020_03_27_012757 120 33 germ germ NN 10_1101-2020_03_27_012757 120 34 cell cell NN 10_1101-2020_03_27_012757 120 35 derived derive VBD 10_1101-2020_03_27_012757 120 36 ovarian ovarian JJ 10_1101-2020_03_27_012757 120 37 tumor tumor NN 10_1101-2020_03_27_012757 120 38 . . . 10_1101-2020_03_27_012757 121 1 Taken take VBN 10_1101-2020_03_27_012757 121 2 together together RB 10_1101-2020_03_27_012757 121 3 , , , 10_1101-2020_03_27_012757 121 4 our -PRON- PRP$ 10_1101-2020_03_27_012757 121 5 results result NNS 10_1101-2020_03_27_012757 121 6 suggest suggest VBP 10_1101-2020_03_27_012757 121 7 that that IN 10_1101-2020_03_27_012757 121 8 SK SK NNP 10_1101-2020_03_27_012757 121 9 - - HYPH 10_1101-2020_03_27_012757 121 10 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 121 11 and and CC 10_1101-2020_03_27_012757 121 12 A2780 A2780 NNP 10_1101-2020_03_27_012757 121 13 287 287 CD 10_1101-2020_03_27_012757 121 14 could could MD 10_1101-2020_03_27_012757 121 15 represent represent VB 10_1101-2020_03_27_012757 121 16 OV OV NNP 10_1101-2020_03_27_012757 121 17 subtypes subtype NNS 10_1101-2020_03_27_012757 121 18 of of IN 10_1101-2020_03_27_012757 121 19 that that DT 10_1101-2020_03_27_012757 121 20 are be VBP 10_1101-2020_03_27_012757 121 21 not not RB 10_1101-2020_03_27_012757 121 22 well well RB 10_1101-2020_03_27_012757 121 23 represented represent VBN 10_1101-2020_03_27_012757 121 24 in in IN 10_1101-2020_03_27_012757 121 25 TCGA TCGA NNP 10_1101-2020_03_27_012757 121 26 training training NN 10_1101-2020_03_27_012757 121 27 data datum NNS 10_1101-2020_03_27_012757 121 28 , , , 10_1101-2020_03_27_012757 121 29 which which WDT 10_1101-2020_03_27_012757 121 30 288 288 CD 10_1101-2020_03_27_012757 121 31 resulted result VBD 10_1101-2020_03_27_012757 121 32 in in IN 10_1101-2020_03_27_012757 121 33 a a DT 10_1101-2020_03_27_012757 121 34 low low JJ 10_1101-2020_03_27_012757 121 35 OV OV NNP 10_1101-2020_03_27_012757 121 36 score score NN 10_1101-2020_03_27_012757 121 37 and and CC 10_1101-2020_03_27_012757 121 38 higher high JJR 10_1101-2020_03_27_012757 121 39 CCN CCN NNP 10_1101-2020_03_27_012757 121 40 score score VBP 10_1101-2020_03_27_012757 121 41 in in IN 10_1101-2020_03_27_012757 121 42 other other JJ 10_1101-2020_03_27_012757 121 43 categories category NNS 10_1101-2020_03_27_012757 121 44 . . . 10_1101-2020_03_27_012757 122 1 289 289 CD 10_1101-2020_03_27_012757 122 2 Lastly lastly RB 10_1101-2020_03_27_012757 122 3 , , , 10_1101-2020_03_27_012757 122 4 we -PRON- PRP 10_1101-2020_03_27_012757 122 5 examined examine VBD 10_1101-2020_03_27_012757 122 6 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 122 7 , , , 10_1101-2020_03_27_012757 122 8 annotated annotate VBD 10_1101-2020_03_27_012757 122 9 as as IN 10_1101-2020_03_27_012757 122 10 a a DT 10_1101-2020_03_27_012757 122 11 PRAD PRAD NNP 10_1101-2020_03_27_012757 122 12 cell cell NN 10_1101-2020_03_27_012757 122 13 line line NN 10_1101-2020_03_27_012757 122 14 but but CC 10_1101-2020_03_27_012757 122 15 classified classify VBD 10_1101-2020_03_27_012757 122 16 to to TO 10_1101-2020_03_27_012757 122 17 be be VB 10_1101-2020_03_27_012757 122 18 most most RBS 10_1101-2020_03_27_012757 122 19 290 290 CD 10_1101-2020_03_27_012757 122 20 similar similar JJ 10_1101-2020_03_27_012757 122 21 to to IN 10_1101-2020_03_27_012757 122 22 BLCA BLCA NNP 10_1101-2020_03_27_012757 122 23 . . . 10_1101-2020_03_27_012757 123 1 We -PRON- PRP 10_1101-2020_03_27_012757 123 2 found find VBD 10_1101-2020_03_27_012757 123 3 that that IN 10_1101-2020_03_27_012757 123 4 30 30 CD 10_1101-2020_03_27_012757 123 5 % % NN 10_1101-2020_03_27_012757 123 6 of of IN 10_1101-2020_03_27_012757 123 7 the the DT 10_1101-2020_03_27_012757 123 8 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 123 9 cells cell NNS 10_1101-2020_03_27_012757 123 10 expressed express VBD 10_1101-2020_03_27_012757 123 11 PPARG PPARG NNP 10_1101-2020_03_27_012757 123 12 , , , 10_1101-2020_03_27_012757 123 13 a a DT 10_1101-2020_03_27_012757 123 14 contributor contributor NN 10_1101-2020_03_27_012757 123 15 to to IN 10_1101-2020_03_27_012757 123 16 291 291 CD 10_1101-2020_03_27_012757 123 17 urothelial urothelial JJ 10_1101-2020_03_27_012757 123 18 differentiation50 differentiation50 NNP 10_1101-2020_03_27_012757 123 19 that that WDT 10_1101-2020_03_27_012757 123 20 is be VBZ 10_1101-2020_03_27_012757 123 21 not not RB 10_1101-2020_03_27_012757 123 22 detected detect VBN 10_1101-2020_03_27_012757 123 23 in in IN 10_1101-2020_03_27_012757 123 24 the the DT 10_1101-2020_03_27_012757 123 25 PRAD PRAD NNP 10_1101-2020_03_27_012757 123 26 Vcap Vcap NNP 10_1101-2020_03_27_012757 123 27 cell cell NN 10_1101-2020_03_27_012757 123 28 line line NN 10_1101-2020_03_27_012757 123 29 but but CC 10_1101-2020_03_27_012757 123 30 is be VBZ 10_1101-2020_03_27_012757 123 31 highly highly RB 10_1101-2020_03_27_012757 123 32 expressed express VBN 10_1101-2020_03_27_012757 123 33 292 292 CD 10_1101-2020_03_27_012757 123 34 .CC .CC NFP 10_1101-2020_03_27_012757 123 35 - - HYPH 10_1101-2020_03_27_012757 123 36 BY by IN 10_1101-2020_03_27_012757 123 37 - - HYPH 10_1101-2020_03_27_012757 123 38 NC NC NNP 10_1101-2020_03_27_012757 123 39 - - HYPH 10_1101-2020_03_27_012757 123 40 ND ND NNP 10_1101-2020_03_27_012757 123 41 4.0 4.0 CD 10_1101-2020_03_27_012757 123 42 International International NNP 10_1101-2020_03_27_012757 123 43 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 123 44 under under IN 10_1101-2020_03_27_012757 123 45 a a DT 10_1101-2020_03_27_012757 123 46 ( ( -LRB- 10_1101-2020_03_27_012757 123 47 which which WDT 10_1101-2020_03_27_012757 123 48 was be VBD 10_1101-2020_03_27_012757 123 49 not not RB 10_1101-2020_03_27_012757 123 50 certified certify VBN 10_1101-2020_03_27_012757 123 51 by by IN 10_1101-2020_03_27_012757 123 52 peer peer NN 10_1101-2020_03_27_012757 123 53 review review NN 10_1101-2020_03_27_012757 123 54 ) ) -RRB- 10_1101-2020_03_27_012757 123 55 is be VBZ 10_1101-2020_03_27_012757 123 56 the the DT 10_1101-2020_03_27_012757 123 57 author author NN 10_1101-2020_03_27_012757 123 58 / / SYM 10_1101-2020_03_27_012757 123 59 funder funder NN 10_1101-2020_03_27_012757 123 60 , , , 10_1101-2020_03_27_012757 123 61 who who WP 10_1101-2020_03_27_012757 123 62 has have VBZ 10_1101-2020_03_27_012757 123 63 granted grant VBN 10_1101-2020_03_27_012757 123 64 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 123 65 a a DT 10_1101-2020_03_27_012757 123 66 license license NN 10_1101-2020_03_27_012757 123 67 to to TO 10_1101-2020_03_27_012757 123 68 display display VB 10_1101-2020_03_27_012757 123 69 the the DT 10_1101-2020_03_27_012757 123 70 preprint preprint NN 10_1101-2020_03_27_012757 123 71 in in IN 10_1101-2020_03_27_012757 123 72 perpetuity perpetuity NN 10_1101-2020_03_27_012757 123 73 . . . 10_1101-2020_03_27_012757 124 1 It -PRON- PRP 10_1101-2020_03_27_012757 124 2 is be VBZ 10_1101-2020_03_27_012757 124 3 made make VBN 10_1101-2020_03_27_012757 124 4 The the DT 10_1101-2020_03_27_012757 124 5 copyright copyright NN 10_1101-2020_03_27_012757 124 6 holder holder NN 10_1101-2020_03_27_012757 124 7 for for IN 10_1101-2020_03_27_012757 124 8 this this DT 10_1101-2020_03_27_012757 124 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 124 10 version version NN 10_1101-2020_03_27_012757 124 11 posted post VBD 10_1101-2020_03_27_012757 124 12 January January NNP 10_1101-2020_03_27_012757 124 13 9 9 CD 10_1101-2020_03_27_012757 124 14 , , , 10_1101-2020_03_27_012757 124 15 2021 2021 CD 10_1101-2020_03_27_012757 124 16 . . . 10_1101-2020_03_27_012757 124 17 ; ; : 10_1101-2020_03_27_012757 124 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 124 19 : : : 10_1101-2020_03_27_012757 124 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 124 21 preprint preprint NN 10_1101-2020_03_27_012757 124 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 RB 10_1101-2020_03_27_012757 124 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 124 24 11 11 CD 10_1101-2020_03_27_012757 124 25 in in IN 10_1101-2020_03_27_012757 124 26 the the DT 10_1101-2020_03_27_012757 124 27 BLCA BLCA NNP 10_1101-2020_03_27_012757 124 28 RT4 RT4 NNP 10_1101-2020_03_27_012757 124 29 cell cell NN 10_1101-2020_03_27_012757 124 30 line line NN 10_1101-2020_03_27_012757 124 31 ( ( -LRB- 10_1101-2020_03_27_012757 124 32 Fig fig NN 10_1101-2020_03_27_012757 124 33 3C 3c NN 10_1101-2020_03_27_012757 124 34 ) ) -RRB- 10_1101-2020_03_27_012757 124 35 . . . 10_1101-2020_03_27_012757 125 1 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 125 2 cells cell NNS 10_1101-2020_03_27_012757 125 3 also also RB 10_1101-2020_03_27_012757 125 4 expressed express VBD 10_1101-2020_03_27_012757 125 5 the the DT 10_1101-2020_03_27_012757 125 6 PRAD PRAD NNP 10_1101-2020_03_27_012757 125 7 biomarker biomarker NN 10_1101-2020_03_27_012757 125 8 FOLH151 FOLH151 NNP 10_1101-2020_03_27_012757 125 9 293 293 CD 10_1101-2020_03_27_012757 125 10 suggesting suggest VBG 10_1101-2020_03_27_012757 125 11 that that IN 10_1101-2020_03_27_012757 125 12 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 125 13 has have VBZ 10_1101-2020_03_27_012757 125 14 an an DT 10_1101-2020_03_27_012757 125 15 PRAD PRAD NNP 10_1101-2020_03_27_012757 125 16 origin origin NN 10_1101-2020_03_27_012757 125 17 and and CC 10_1101-2020_03_27_012757 125 18 gained gain VBD 10_1101-2020_03_27_012757 125 19 urothelial urothelial JJ 10_1101-2020_03_27_012757 125 20 or or CC 10_1101-2020_03_27_012757 125 21 luminal luminal JJ 10_1101-2020_03_27_012757 125 22 characteristics characteristic NNS 10_1101-2020_03_27_012757 125 23 294 294 CD 10_1101-2020_03_27_012757 125 24 through through IN 10_1101-2020_03_27_012757 125 25 the the DT 10_1101-2020_03_27_012757 125 26 derivation derivation NN 10_1101-2020_03_27_012757 125 27 process process NN 10_1101-2020_03_27_012757 125 28 . . . 10_1101-2020_03_27_012757 126 1 In in IN 10_1101-2020_03_27_012757 126 2 short short JJ 10_1101-2020_03_27_012757 126 3 , , , 10_1101-2020_03_27_012757 126 4 our -PRON- PRP$ 10_1101-2020_03_27_012757 126 5 limited limited JJ 10_1101-2020_03_27_012757 126 6 experimental experimental JJ 10_1101-2020_03_27_012757 126 7 data datum NNS 10_1101-2020_03_27_012757 126 8 support support VBP 10_1101-2020_03_27_012757 126 9 the the DT 10_1101-2020_03_27_012757 126 10 CCN CCN NNP 10_1101-2020_03_27_012757 126 11 295 295 CD 10_1101-2020_03_27_012757 126 12 classification classification NN 10_1101-2020_03_27_012757 126 13 results result NNS 10_1101-2020_03_27_012757 126 14 . . . 10_1101-2020_03_27_012757 127 1 296 296 CD 10_1101-2020_03_27_012757 127 2 297 297 CD 10_1101-2020_03_27_012757 127 3 Subtype subtype NN 10_1101-2020_03_27_012757 127 4 classification classification NN 10_1101-2020_03_27_012757 127 5 of of IN 10_1101-2020_03_27_012757 127 6 cancer cancer NN 10_1101-2020_03_27_012757 127 7 cell cell NN 10_1101-2020_03_27_012757 127 8 lines line NNS 10_1101-2020_03_27_012757 127 9 298 298 CD 10_1101-2020_03_27_012757 127 10 Next next RB 10_1101-2020_03_27_012757 127 11 , , , 10_1101-2020_03_27_012757 127 12 we -PRON- PRP 10_1101-2020_03_27_012757 127 13 explored explore VBD 10_1101-2020_03_27_012757 127 14 the the DT 10_1101-2020_03_27_012757 127 15 subtype subtype NN 10_1101-2020_03_27_012757 127 16 classification classification NN 10_1101-2020_03_27_012757 127 17 of of IN 10_1101-2020_03_27_012757 127 18 CCLs CCLs NNP 10_1101-2020_03_27_012757 127 19 from from IN 10_1101-2020_03_27_012757 127 20 three three CD 10_1101-2020_03_27_012757 127 21 general general JJ 10_1101-2020_03_27_012757 127 22 tumor tumor NN 10_1101-2020_03_27_012757 127 23 types type NNS 10_1101-2020_03_27_012757 127 24 in in IN 10_1101-2020_03_27_012757 127 25 299 299 CD 10_1101-2020_03_27_012757 127 26 more more JJR 10_1101-2020_03_27_012757 127 27 depth depth NN 10_1101-2020_03_27_012757 127 28 . . . 10_1101-2020_03_27_012757 128 1 We -PRON- PRP 10_1101-2020_03_27_012757 128 2 focused focus VBD 10_1101-2020_03_27_012757 128 3 our -PRON- PRP$ 10_1101-2020_03_27_012757 128 4 subtype subtype NN 10_1101-2020_03_27_012757 128 5 visualization visualization NN 10_1101-2020_03_27_012757 128 6 ( ( -LRB- 10_1101-2020_03_27_012757 128 7 Fig Fig NNP 10_1101-2020_03_27_012757 128 8 4A 4A NNP 10_1101-2020_03_27_012757 128 9 - - HYPH 10_1101-2020_03_27_012757 128 10 C C NNP 10_1101-2020_03_27_012757 128 11 ) ) -RRB- 10_1101-2020_03_27_012757 128 12 on on IN 10_1101-2020_03_27_012757 128 13 CCL CCL NNP 10_1101-2020_03_27_012757 128 14 models model NNS 10_1101-2020_03_27_012757 128 15 with with IN 10_1101-2020_03_27_012757 128 16 general general JJ 10_1101-2020_03_27_012757 128 17 CCN CCN NNP 10_1101-2020_03_27_012757 128 18 300 300 CD 10_1101-2020_03_27_012757 128 19 score score NN 10_1101-2020_03_27_012757 128 20 above above IN 10_1101-2020_03_27_012757 128 21 0.1 0.1 CD 10_1101-2020_03_27_012757 128 22 in in IN 10_1101-2020_03_27_012757 128 23 their -PRON- PRP$ 10_1101-2020_03_27_012757 128 24 nominal nominal JJ 10_1101-2020_03_27_012757 128 25 cancer cancer NN 10_1101-2020_03_27_012757 128 26 type type NN 10_1101-2020_03_27_012757 128 27 as as IN 10_1101-2020_03_27_012757 128 28 this this DT 10_1101-2020_03_27_012757 128 29 allowed allow VBD 10_1101-2020_03_27_012757 128 30 us -PRON- PRP 10_1101-2020_03_27_012757 128 31 to to TO 10_1101-2020_03_27_012757 128 32 analyze analyze VB 10_1101-2020_03_27_012757 128 33 those those DT 10_1101-2020_03_27_012757 128 34 models model NNS 10_1101-2020_03_27_012757 128 35 that that WDT 10_1101-2020_03_27_012757 128 36 fell fall VBD 10_1101-2020_03_27_012757 128 37 301 301 CD 10_1101-2020_03_27_012757 128 38 below below IN 10_1101-2020_03_27_012757 128 39 the the DT 10_1101-2020_03_27_012757 128 40 general general JJ 10_1101-2020_03_27_012757 128 41 threshold threshold NN 10_1101-2020_03_27_012757 128 42 but but CC 10_1101-2020_03_27_012757 128 43 were be VBD 10_1101-2020_03_27_012757 128 44 classified classify VBN 10_1101-2020_03_27_012757 128 45 as as IN 10_1101-2020_03_27_012757 128 46 a a DT 10_1101-2020_03_27_012757 128 47 specific specific JJ 10_1101-2020_03_27_012757 128 48 sub sub JJ 10_1101-2020_03_27_012757 128 49 - - HYPH 10_1101-2020_03_27_012757 128 50 type type NN 10_1101-2020_03_27_012757 128 51 ( ( -LRB- 10_1101-2020_03_27_012757 128 52 Supp Supp NNP 10_1101-2020_03_27_012757 128 53 Tab Tab NNP 10_1101-2020_03_27_012757 128 54 1 1 CD 10_1101-2020_03_27_012757 128 55 - - SYM 10_1101-2020_03_27_012757 128 56 2 2 CD 10_1101-2020_03_27_012757 128 57 ) ) -RRB- 10_1101-2020_03_27_012757 128 58 . . . 10_1101-2020_03_27_012757 129 1 302 302 CD 10_1101-2020_03_27_012757 129 2 Focusing focus VBG 10_1101-2020_03_27_012757 129 3 first first RB 10_1101-2020_03_27_012757 129 4 on on IN 10_1101-2020_03_27_012757 129 5 UCEC UCEC NNP 10_1101-2020_03_27_012757 129 6 , , , 10_1101-2020_03_27_012757 129 7 the the DT 10_1101-2020_03_27_012757 129 8 histologically histologically RB 10_1101-2020_03_27_012757 129 9 defined define VBN 10_1101-2020_03_27_012757 129 10 subtypes subtype NNS 10_1101-2020_03_27_012757 129 11 of of IN 10_1101-2020_03_27_012757 129 12 UCEC UCEC NNP 10_1101-2020_03_27_012757 129 13 , , , 10_1101-2020_03_27_012757 129 14 endometrioid endometrioid NN 10_1101-2020_03_27_012757 129 15 and and CC 10_1101-2020_03_27_012757 129 16 serous serous JJ 10_1101-2020_03_27_012757 129 17 , , , 10_1101-2020_03_27_012757 129 18 303 303 CD 10_1101-2020_03_27_012757 129 19 differ differ NN 10_1101-2020_03_27_012757 129 20 in in IN 10_1101-2020_03_27_012757 129 21 prevalence prevalence NN 10_1101-2020_03_27_012757 129 22 , , , 10_1101-2020_03_27_012757 129 23 molecular molecular JJ 10_1101-2020_03_27_012757 129 24 properties property NNS 10_1101-2020_03_27_012757 129 25 , , , 10_1101-2020_03_27_012757 129 26 prognosis prognosis NN 10_1101-2020_03_27_012757 129 27 , , , 10_1101-2020_03_27_012757 129 28 and and CC 10_1101-2020_03_27_012757 129 29 treatment treatment NN 10_1101-2020_03_27_012757 129 30 . . . 10_1101-2020_03_27_012757 130 1 For for IN 10_1101-2020_03_27_012757 130 2 instance instance NN 10_1101-2020_03_27_012757 130 3 , , , 10_1101-2020_03_27_012757 130 4 the the DT 10_1101-2020_03_27_012757 130 5 304 304 CD 10_1101-2020_03_27_012757 130 6 endometrioid endometrioid NN 10_1101-2020_03_27_012757 130 7 subtype subtype NN 10_1101-2020_03_27_012757 130 8 , , , 10_1101-2020_03_27_012757 130 9 which which WDT 10_1101-2020_03_27_012757 130 10 accounts account VBZ 10_1101-2020_03_27_012757 130 11 for for IN 10_1101-2020_03_27_012757 130 12 approximately approximately RB 10_1101-2020_03_27_012757 130 13 80 80 CD 10_1101-2020_03_27_012757 130 14 % % NN 10_1101-2020_03_27_012757 130 15 of of IN 10_1101-2020_03_27_012757 130 16 uterine uterine JJ 10_1101-2020_03_27_012757 130 17 cancers cancer NNS 10_1101-2020_03_27_012757 130 18 , , , 10_1101-2020_03_27_012757 130 19 retains retain VBZ 10_1101-2020_03_27_012757 130 20 305 305 CD 10_1101-2020_03_27_012757 130 21 estrogen estrogen NN 10_1101-2020_03_27_012757 130 22 receptor receptor NN 10_1101-2020_03_27_012757 130 23 and and CC 10_1101-2020_03_27_012757 130 24 progesterone progesterone NN 10_1101-2020_03_27_012757 130 25 receptor receptor NN 10_1101-2020_03_27_012757 130 26 status status NN 10_1101-2020_03_27_012757 130 27 and and CC 10_1101-2020_03_27_012757 130 28 is be VBZ 10_1101-2020_03_27_012757 130 29 responsive responsive JJ 10_1101-2020_03_27_012757 130 30 towards towards IN 10_1101-2020_03_27_012757 130 31 progestin progestin NNP 10_1101-2020_03_27_012757 130 32 306 306 CD 10_1101-2020_03_27_012757 130 33 therapy52,53 therapy52,53 NNP 10_1101-2020_03_27_012757 130 34 . . . 10_1101-2020_03_27_012757 131 1 Serous serous JJ 10_1101-2020_03_27_012757 131 2 , , , 10_1101-2020_03_27_012757 131 3 a a DT 10_1101-2020_03_27_012757 131 4 more more RBR 10_1101-2020_03_27_012757 131 5 aggressive aggressive JJ 10_1101-2020_03_27_012757 131 6 subtype subtype NN 10_1101-2020_03_27_012757 131 7 , , , 10_1101-2020_03_27_012757 131 8 is be VBZ 10_1101-2020_03_27_012757 131 9 characterized characterize VBN 10_1101-2020_03_27_012757 131 10 by by IN 10_1101-2020_03_27_012757 131 11 the the DT 10_1101-2020_03_27_012757 131 12 loss loss NN 10_1101-2020_03_27_012757 131 13 of of IN 10_1101-2020_03_27_012757 131 14 estrogen estrogen NN 10_1101-2020_03_27_012757 131 15 and and CC 10_1101-2020_03_27_012757 131 16 307 307 CD 10_1101-2020_03_27_012757 131 17 progesterone progesterone NN 10_1101-2020_03_27_012757 131 18 receptor receptor NN 10_1101-2020_03_27_012757 131 19 and and CC 10_1101-2020_03_27_012757 131 20 is be VBZ 10_1101-2020_03_27_012757 131 21 not not RB 10_1101-2020_03_27_012757 131 22 responsive responsive JJ 10_1101-2020_03_27_012757 131 23 to to IN 10_1101-2020_03_27_012757 131 24 progestin progestin NNP 10_1101-2020_03_27_012757 131 25 therapy52,53 therapy52,53 NNP 10_1101-2020_03_27_012757 131 26 . . . 10_1101-2020_03_27_012757 132 1 CCN CCN NNP 10_1101-2020_03_27_012757 132 2 classified classify VBD 10_1101-2020_03_27_012757 132 3 the the DT 10_1101-2020_03_27_012757 132 4 308 308 CD 10_1101-2020_03_27_012757 132 5 majority majority NN 10_1101-2020_03_27_012757 132 6 of of IN 10_1101-2020_03_27_012757 132 7 the the DT 10_1101-2020_03_27_012757 132 8 UCEC UCEC NNP 10_1101-2020_03_27_012757 132 9 cell cell NN 10_1101-2020_03_27_012757 132 10 lines line NNS 10_1101-2020_03_27_012757 132 11 as as IN 10_1101-2020_03_27_012757 132 12 serous serous JJ 10_1101-2020_03_27_012757 132 13 except except IN 10_1101-2020_03_27_012757 132 14 for for IN 10_1101-2020_03_27_012757 132 15 JHUEM-1 JHUEM-1 NNP 10_1101-2020_03_27_012757 132 16 which which WDT 10_1101-2020_03_27_012757 132 17 is be VBZ 10_1101-2020_03_27_012757 132 18 classified classify VBN 10_1101-2020_03_27_012757 132 19 as as IN 10_1101-2020_03_27_012757 132 20 mixed mixed JJ 10_1101-2020_03_27_012757 132 21 , , , 10_1101-2020_03_27_012757 132 22 with with IN 10_1101-2020_03_27_012757 132 23 309 309 CD 10_1101-2020_03_27_012757 132 24 similarities similarity NNS 10_1101-2020_03_27_012757 132 25 to to IN 10_1101-2020_03_27_012757 132 26 both both DT 10_1101-2020_03_27_012757 132 27 endometrioid endometrioid NN 10_1101-2020_03_27_012757 132 28 and and CC 10_1101-2020_03_27_012757 132 29 serous serous JJ 10_1101-2020_03_27_012757 132 30 ( ( -LRB- 10_1101-2020_03_27_012757 132 31 Fig Fig NNP 10_1101-2020_03_27_012757 132 32 4A 4A NNP 10_1101-2020_03_27_012757 132 33 ) ) -RRB- 10_1101-2020_03_27_012757 132 34 . . . 10_1101-2020_03_27_012757 133 1 The the DT 10_1101-2020_03_27_012757 133 2 preponderance preponderance NN 10_1101-2020_03_27_012757 133 3 CCLE ccle JJ 10_1101-2020_03_27_012757 133 4 lines line NNS 10_1101-2020_03_27_012757 133 5 of of IN 10_1101-2020_03_27_012757 133 6 serous serous JJ 10_1101-2020_03_27_012757 133 7 310 310 CD 10_1101-2020_03_27_012757 133 8 versus versus IN 10_1101-2020_03_27_012757 133 9 endometroid endometroid JJ 10_1101-2020_03_27_012757 133 10 character character NN 10_1101-2020_03_27_012757 133 11 may may MD 10_1101-2020_03_27_012757 133 12 be be VB 10_1101-2020_03_27_012757 133 13 due due IN 10_1101-2020_03_27_012757 133 14 to to IN 10_1101-2020_03_27_012757 133 15 properties property NNS 10_1101-2020_03_27_012757 133 16 of of IN 10_1101-2020_03_27_012757 133 17 serous serous JJ 10_1101-2020_03_27_012757 133 18 cancer cancer NN 10_1101-2020_03_27_012757 133 19 cells cell NNS 10_1101-2020_03_27_012757 133 20 that that WDT 10_1101-2020_03_27_012757 133 21 promote promote VBP 10_1101-2020_03_27_012757 133 22 311 311 CD 10_1101-2020_03_27_012757 133 23 their -PRON- PRP$ 10_1101-2020_03_27_012757 133 24 in in FW 10_1101-2020_03_27_012757 133 25 vitro vitro FW 10_1101-2020_03_27_012757 133 26 propagation propagation NN 10_1101-2020_03_27_012757 133 27 , , , 10_1101-2020_03_27_012757 133 28 such such JJ 10_1101-2020_03_27_012757 133 29 as as IN 10_1101-2020_03_27_012757 133 30 upregulation upregulation NN 10_1101-2020_03_27_012757 133 31 of of IN 10_1101-2020_03_27_012757 133 32 cell cell NN 10_1101-2020_03_27_012757 133 33 adhesion adhesion NN 10_1101-2020_03_27_012757 133 34 transcriptional transcriptional NNP 10_1101-2020_03_27_012757 133 35 programs54 programs54 NNP 10_1101-2020_03_27_012757 133 36 . . . 10_1101-2020_03_27_012757 134 1 312 312 CD 10_1101-2020_03_27_012757 134 2 Some some DT 10_1101-2020_03_27_012757 134 3 of of IN 10_1101-2020_03_27_012757 134 4 our -PRON- PRP$ 10_1101-2020_03_27_012757 134 5 subtype subtype NN 10_1101-2020_03_27_012757 134 6 classification classification NN 10_1101-2020_03_27_012757 134 7 results result NNS 10_1101-2020_03_27_012757 134 8 are be VBP 10_1101-2020_03_27_012757 134 9 consistent consistent JJ 10_1101-2020_03_27_012757 134 10 with with IN 10_1101-2020_03_27_012757 134 11 prior prior JJ 10_1101-2020_03_27_012757 134 12 observations observation NNS 10_1101-2020_03_27_012757 134 13 . . . 10_1101-2020_03_27_012757 135 1 For for IN 10_1101-2020_03_27_012757 135 2 example example NN 10_1101-2020_03_27_012757 135 3 , , , 10_1101-2020_03_27_012757 135 4 313 313 CD 10_1101-2020_03_27_012757 135 5 HEC-1A hec-1a UH 10_1101-2020_03_27_012757 135 6 , , , 10_1101-2020_03_27_012757 135 7 HEC-1B HEC-1B NNP 10_1101-2020_03_27_012757 135 8 , , , 10_1101-2020_03_27_012757 135 9 and and CC 10_1101-2020_03_27_012757 135 10 KLE KLE NNP 10_1101-2020_03_27_012757 135 11 were be VBD 10_1101-2020_03_27_012757 135 12 previously previously RB 10_1101-2020_03_27_012757 135 13 characterized characterize VBN 10_1101-2020_03_27_012757 135 14 as as IN 10_1101-2020_03_27_012757 135 15 type type NN 10_1101-2020_03_27_012757 135 16 II II NNP 10_1101-2020_03_27_012757 135 17 endometrial endometrial JJ 10_1101-2020_03_27_012757 135 18 cancer cancer NN 10_1101-2020_03_27_012757 135 19 , , , 10_1101-2020_03_27_012757 135 20 which which WDT 10_1101-2020_03_27_012757 135 21 314 314 CD 10_1101-2020_03_27_012757 135 22 includes include VBZ 10_1101-2020_03_27_012757 135 23 a a DT 10_1101-2020_03_27_012757 135 24 serous serous JJ 10_1101-2020_03_27_012757 135 25 histological histological JJ 10_1101-2020_03_27_012757 135 26 subtype55 subtype55 NN 10_1101-2020_03_27_012757 135 27 . . . 10_1101-2020_03_27_012757 136 1 On on IN 10_1101-2020_03_27_012757 136 2 the the DT 10_1101-2020_03_27_012757 136 3 other other JJ 10_1101-2020_03_27_012757 136 4 hand hand NN 10_1101-2020_03_27_012757 136 5 , , , 10_1101-2020_03_27_012757 136 6 our -PRON- PRP$ 10_1101-2020_03_27_012757 136 7 subtype subtype NN 10_1101-2020_03_27_012757 136 8 classification classification NN 10_1101-2020_03_27_012757 136 9 results result VBZ 10_1101-2020_03_27_012757 136 10 315 315 CD 10_1101-2020_03_27_012757 136 11 contradict contradict NN 10_1101-2020_03_27_012757 136 12 prior prior JJ 10_1101-2020_03_27_012757 136 13 observations observation NNS 10_1101-2020_03_27_012757 136 14 in in IN 10_1101-2020_03_27_012757 136 15 at at RB 10_1101-2020_03_27_012757 136 16 least least RBS 10_1101-2020_03_27_012757 136 17 one one CD 10_1101-2020_03_27_012757 136 18 case case NN 10_1101-2020_03_27_012757 136 19 . . . 10_1101-2020_03_27_012757 137 1 For for IN 10_1101-2020_03_27_012757 137 2 instance instance NN 10_1101-2020_03_27_012757 137 3 , , , 10_1101-2020_03_27_012757 137 4 the the DT 10_1101-2020_03_27_012757 137 5 Ishikawa Ishikawa NNP 10_1101-2020_03_27_012757 137 6 cell cell NN 10_1101-2020_03_27_012757 137 7 line line NN 10_1101-2020_03_27_012757 137 8 was be VBD 10_1101-2020_03_27_012757 137 9 316 316 CD 10_1101-2020_03_27_012757 137 10 derived derive VBN 10_1101-2020_03_27_012757 137 11 from from IN 10_1101-2020_03_27_012757 137 12 type type NN 10_1101-2020_03_27_012757 137 13 I -PRON- PRP 10_1101-2020_03_27_012757 137 14 endometrial endometrial JJ 10_1101-2020_03_27_012757 137 15 cancer cancer NN 10_1101-2020_03_27_012757 137 16 ( ( -LRB- 10_1101-2020_03_27_012757 137 17 endometrioid endometrioid NNP 10_1101-2020_03_27_012757 137 18 histological histological NNP 10_1101-2020_03_27_012757 137 19 subtype)55,56 subtype)55,56 NNP 10_1101-2020_03_27_012757 137 20 , , , 10_1101-2020_03_27_012757 137 21 however however RB 10_1101-2020_03_27_012757 137 22 CCN CCN NNP 10_1101-2020_03_27_012757 137 23 317 317 CD 10_1101-2020_03_27_012757 137 24 classified classify VBD 10_1101-2020_03_27_012757 137 25 a a DT 10_1101-2020_03_27_012757 137 26 derivative derivative NN 10_1101-2020_03_27_012757 137 27 of of IN 10_1101-2020_03_27_012757 137 28 this this DT 10_1101-2020_03_27_012757 137 29 line line NN 10_1101-2020_03_27_012757 137 30 , , , 10_1101-2020_03_27_012757 137 31 Ishikawa Ishikawa NNP 10_1101-2020_03_27_012757 137 32 02 02 CD 10_1101-2020_03_27_012757 137 33 ER- ER- NNP 10_1101-2020_03_27_012757 137 34 , , , 10_1101-2020_03_27_012757 137 35 as as RB 10_1101-2020_03_27_012757 137 36 serous serous JJ 10_1101-2020_03_27_012757 137 37 . . . 10_1101-2020_03_27_012757 138 1 The the DT 10_1101-2020_03_27_012757 138 2 high high JJ 10_1101-2020_03_27_012757 138 3 serous serous JJ 10_1101-2020_03_27_012757 138 4 CCN CCN NNP 10_1101-2020_03_27_012757 138 5 score score VBP 10_1101-2020_03_27_012757 138 6 318 318 CD 10_1101-2020_03_27_012757 138 7 .CC .CC , 10_1101-2020_03_27_012757 138 8 - - HYPH 10_1101-2020_03_27_012757 138 9 BY by IN 10_1101-2020_03_27_012757 138 10 - - HYPH 10_1101-2020_03_27_012757 138 11 NC NC NNP 10_1101-2020_03_27_012757 138 12 - - HYPH 10_1101-2020_03_27_012757 138 13 ND ND NNP 10_1101-2020_03_27_012757 138 14 4.0 4.0 CD 10_1101-2020_03_27_012757 138 15 International International NNP 10_1101-2020_03_27_012757 138 16 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 138 17 under under IN 10_1101-2020_03_27_012757 138 18 a a DT 10_1101-2020_03_27_012757 138 19 ( ( -LRB- 10_1101-2020_03_27_012757 138 20 which which WDT 10_1101-2020_03_27_012757 138 21 was be VBD 10_1101-2020_03_27_012757 138 22 not not RB 10_1101-2020_03_27_012757 138 23 certified certify VBN 10_1101-2020_03_27_012757 138 24 by by IN 10_1101-2020_03_27_012757 138 25 peer peer NN 10_1101-2020_03_27_012757 138 26 review review NN 10_1101-2020_03_27_012757 138 27 ) ) -RRB- 10_1101-2020_03_27_012757 138 28 is be VBZ 10_1101-2020_03_27_012757 138 29 the the DT 10_1101-2020_03_27_012757 138 30 author author NN 10_1101-2020_03_27_012757 138 31 / / SYM 10_1101-2020_03_27_012757 138 32 funder funder NN 10_1101-2020_03_27_012757 138 33 , , , 10_1101-2020_03_27_012757 138 34 who who WP 10_1101-2020_03_27_012757 138 35 has have VBZ 10_1101-2020_03_27_012757 138 36 granted grant VBN 10_1101-2020_03_27_012757 138 37 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 138 38 a a DT 10_1101-2020_03_27_012757 138 39 license license NN 10_1101-2020_03_27_012757 138 40 to to TO 10_1101-2020_03_27_012757 138 41 display display VB 10_1101-2020_03_27_012757 138 42 the the DT 10_1101-2020_03_27_012757 138 43 preprint preprint NN 10_1101-2020_03_27_012757 138 44 in in IN 10_1101-2020_03_27_012757 138 45 perpetuity perpetuity NN 10_1101-2020_03_27_012757 138 46 . . . 10_1101-2020_03_27_012757 139 1 It -PRON- PRP 10_1101-2020_03_27_012757 139 2 is be VBZ 10_1101-2020_03_27_012757 139 3 made make VBN 10_1101-2020_03_27_012757 139 4 The the DT 10_1101-2020_03_27_012757 139 5 copyright copyright NN 10_1101-2020_03_27_012757 139 6 holder holder NN 10_1101-2020_03_27_012757 139 7 for for IN 10_1101-2020_03_27_012757 139 8 this this DT 10_1101-2020_03_27_012757 139 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 139 10 version version NN 10_1101-2020_03_27_012757 139 11 posted post VBD 10_1101-2020_03_27_012757 139 12 January January NNP 10_1101-2020_03_27_012757 139 13 9 9 CD 10_1101-2020_03_27_012757 139 14 , , , 10_1101-2020_03_27_012757 139 15 2021 2021 CD 10_1101-2020_03_27_012757 139 16 . . . 10_1101-2020_03_27_012757 139 17 ; ; : 10_1101-2020_03_27_012757 139 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 139 19 : : : 10_1101-2020_03_27_012757 139 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 139 21 preprint preprint NN 10_1101-2020_03_27_012757 139 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 139 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 139 24 12 12 CD 10_1101-2020_03_27_012757 139 25 could could MD 10_1101-2020_03_27_012757 139 26 result result VB 10_1101-2020_03_27_012757 139 27 from from IN 10_1101-2020_03_27_012757 139 28 a a DT 10_1101-2020_03_27_012757 139 29 shift shift NN 10_1101-2020_03_27_012757 139 30 in in IN 10_1101-2020_03_27_012757 139 31 phenotype phenotype NN 10_1101-2020_03_27_012757 139 32 of of IN 10_1101-2020_03_27_012757 139 33 the the DT 10_1101-2020_03_27_012757 139 34 line line NN 10_1101-2020_03_27_012757 139 35 concomitant concomitant JJ 10_1101-2020_03_27_012757 139 36 with with IN 10_1101-2020_03_27_012757 139 37 its -PRON- PRP$ 10_1101-2020_03_27_012757 139 38 loss loss NN 10_1101-2020_03_27_012757 139 39 of of IN 10_1101-2020_03_27_012757 139 40 estrogen estrogen NN 10_1101-2020_03_27_012757 139 41 receptor receptor NN 10_1101-2020_03_27_012757 139 42 319 319 CD 10_1101-2020_03_27_012757 139 43 ( ( -LRB- 10_1101-2020_03_27_012757 139 44 ER ER NNP 10_1101-2020_03_27_012757 139 45 ) ) -RRB- 10_1101-2020_03_27_012757 139 46 as as IN 10_1101-2020_03_27_012757 139 47 this this DT 10_1101-2020_03_27_012757 139 48 is be VBZ 10_1101-2020_03_27_012757 139 49 a a DT 10_1101-2020_03_27_012757 139 50 distinguishing distinguish VBG 10_1101-2020_03_27_012757 139 51 feature feature NN 10_1101-2020_03_27_012757 139 52 of of IN 10_1101-2020_03_27_012757 139 53 type type NN 10_1101-2020_03_27_012757 139 54 II II NNP 10_1101-2020_03_27_012757 139 55 endometrial endometrial JJ 10_1101-2020_03_27_012757 139 56 cancer cancer NN 10_1101-2020_03_27_012757 139 57 ( ( -LRB- 10_1101-2020_03_27_012757 139 58 serous serous JJ 10_1101-2020_03_27_012757 139 59 histological histological NNP 10_1101-2020_03_27_012757 139 60 320 320 CD 10_1101-2020_03_27_012757 139 61 subtype)52 subtype)52 NNS 10_1101-2020_03_27_012757 139 62 . . . 10_1101-2020_03_27_012757 140 1 Taken take VBN 10_1101-2020_03_27_012757 140 2 together together RB 10_1101-2020_03_27_012757 140 3 , , , 10_1101-2020_03_27_012757 140 4 these these DT 10_1101-2020_03_27_012757 140 5 results result NNS 10_1101-2020_03_27_012757 140 6 indicate indicate VBP 10_1101-2020_03_27_012757 140 7 a a DT 10_1101-2020_03_27_012757 140 8 need need NN 10_1101-2020_03_27_012757 140 9 for for IN 10_1101-2020_03_27_012757 140 10 more more JJR 10_1101-2020_03_27_012757 140 11 endometroid endometroid NN 10_1101-2020_03_27_012757 140 12 - - HYPH 10_1101-2020_03_27_012757 140 13 like like JJ 10_1101-2020_03_27_012757 140 14 CCLs ccl NNS 10_1101-2020_03_27_012757 140 15 . . . 10_1101-2020_03_27_012757 141 1 321 321 CD 10_1101-2020_03_27_012757 141 2 Next next RB 10_1101-2020_03_27_012757 141 3 , , , 10_1101-2020_03_27_012757 141 4 we -PRON- PRP 10_1101-2020_03_27_012757 141 5 examined examine VBD 10_1101-2020_03_27_012757 141 6 the the DT 10_1101-2020_03_27_012757 141 7 subtype subtype NN 10_1101-2020_03_27_012757 141 8 classification classification NN 10_1101-2020_03_27_012757 141 9 of of IN 10_1101-2020_03_27_012757 141 10 Lung Lung NNP 10_1101-2020_03_27_012757 141 11 Squamous Squamous NNP 10_1101-2020_03_27_012757 141 12 Cell Cell NNP 10_1101-2020_03_27_012757 141 13 Carcinoma Carcinoma NNP 10_1101-2020_03_27_012757 141 14 322 322 CD 10_1101-2020_03_27_012757 141 15 ( ( -LRB- 10_1101-2020_03_27_012757 141 16 LUSC LUSC NNP 10_1101-2020_03_27_012757 141 17 ) ) -RRB- 10_1101-2020_03_27_012757 141 18 and and CC 10_1101-2020_03_27_012757 141 19 Lung Lung NNP 10_1101-2020_03_27_012757 141 20 adenocarcinoma adenocarcinoma NN 10_1101-2020_03_27_012757 141 21 ( ( -LRB- 10_1101-2020_03_27_012757 141 22 LUAD luad RB 10_1101-2020_03_27_012757 141 23 ) ) -RRB- 10_1101-2020_03_27_012757 141 24 cell cell NN 10_1101-2020_03_27_012757 141 25 lines line NNS 10_1101-2020_03_27_012757 141 26 ( ( -LRB- 10_1101-2020_03_27_012757 141 27 Fig Fig NNP 10_1101-2020_03_27_012757 141 28 4B 4b NN 10_1101-2020_03_27_012757 141 29 - - HYPH 10_1101-2020_03_27_012757 141 30 C c NN 10_1101-2020_03_27_012757 141 31 ) ) -RRB- 10_1101-2020_03_27_012757 141 32 . . . 10_1101-2020_03_27_012757 142 1 All all PDT 10_1101-2020_03_27_012757 142 2 the the DT 10_1101-2020_03_27_012757 142 3 LUSC LUSC NNP 10_1101-2020_03_27_012757 142 4 lines line NNS 10_1101-2020_03_27_012757 142 5 with with IN 10_1101-2020_03_27_012757 142 6 at at RB 10_1101-2020_03_27_012757 142 7 least least RBS 10_1101-2020_03_27_012757 142 8 323 323 CD 10_1101-2020_03_27_012757 142 9 one one CD 10_1101-2020_03_27_012757 142 10 subtype subtype NN 10_1101-2020_03_27_012757 142 11 classification classification NN 10_1101-2020_03_27_012757 142 12 had have VBD 10_1101-2020_03_27_012757 142 13 an an DT 10_1101-2020_03_27_012757 142 14 underlying underlie VBG 10_1101-2020_03_27_012757 142 15 primitive primitive JJ 10_1101-2020_03_27_012757 142 16 subtype subtype NN 10_1101-2020_03_27_012757 142 17 classification classification NN 10_1101-2020_03_27_012757 142 18 . . . 10_1101-2020_03_27_012757 143 1 This this DT 10_1101-2020_03_27_012757 143 2 is be VBZ 10_1101-2020_03_27_012757 143 3 consistent consistent JJ 10_1101-2020_03_27_012757 143 4 324 324 CD 10_1101-2020_03_27_012757 143 5 either either CC 10_1101-2020_03_27_012757 143 6 with with IN 10_1101-2020_03_27_012757 143 7 the the DT 10_1101-2020_03_27_012757 143 8 ease ease NN 10_1101-2020_03_27_012757 143 9 of of IN 10_1101-2020_03_27_012757 143 10 deriving derive VBG 10_1101-2020_03_27_012757 143 11 lines line NNS 10_1101-2020_03_27_012757 143 12 from from IN 10_1101-2020_03_27_012757 143 13 tumors tumor NNS 10_1101-2020_03_27_012757 143 14 with with IN 10_1101-2020_03_27_012757 143 15 a a DT 10_1101-2020_03_27_012757 143 16 primitive primitive JJ 10_1101-2020_03_27_012757 143 17 character character NN 10_1101-2020_03_27_012757 143 18 , , , 10_1101-2020_03_27_012757 143 19 or or CC 10_1101-2020_03_27_012757 143 20 with with IN 10_1101-2020_03_27_012757 143 21 a a DT 10_1101-2020_03_27_012757 143 22 process process NN 10_1101-2020_03_27_012757 143 23 by by IN 10_1101-2020_03_27_012757 143 24 325 325 CD 10_1101-2020_03_27_012757 143 25 which which WDT 10_1101-2020_03_27_012757 143 26 cell cell NN 10_1101-2020_03_27_012757 143 27 line line NN 10_1101-2020_03_27_012757 143 28 derivation derivation NN 10_1101-2020_03_27_012757 143 29 promotes promote VBZ 10_1101-2020_03_27_012757 143 30 similarity similarity NN 10_1101-2020_03_27_012757 143 31 to to IN 10_1101-2020_03_27_012757 143 32 more more RBR 10_1101-2020_03_27_012757 143 33 primitive primitive JJ 10_1101-2020_03_27_012757 143 34 subtype subtype NN 10_1101-2020_03_27_012757 143 35 , , , 10_1101-2020_03_27_012757 143 36 which which WDT 10_1101-2020_03_27_012757 143 37 is be VBZ 10_1101-2020_03_27_012757 143 38 marked mark VBN 10_1101-2020_03_27_012757 143 39 by by IN 10_1101-2020_03_27_012757 143 40 326 326 CD 10_1101-2020_03_27_012757 143 41 increased increased JJ 10_1101-2020_03_27_012757 143 42 cellular cellular JJ 10_1101-2020_03_27_012757 143 43 proliferation28 proliferation28 NNS 10_1101-2020_03_27_012757 143 44 . . . 10_1101-2020_03_27_012757 144 1 Some some DT 10_1101-2020_03_27_012757 144 2 of of IN 10_1101-2020_03_27_012757 144 3 our -PRON- PRP$ 10_1101-2020_03_27_012757 144 4 results result NNS 10_1101-2020_03_27_012757 144 5 are be VBP 10_1101-2020_03_27_012757 144 6 consistent consistent JJ 10_1101-2020_03_27_012757 144 7 with with IN 10_1101-2020_03_27_012757 144 8 prior prior JJ 10_1101-2020_03_27_012757 144 9 reports report NNS 10_1101-2020_03_27_012757 144 10 that that WDT 10_1101-2020_03_27_012757 144 11 have have VBP 10_1101-2020_03_27_012757 144 12 327 327 CD 10_1101-2020_03_27_012757 144 13 investigated investigate VBN 10_1101-2020_03_27_012757 144 14 the the DT 10_1101-2020_03_27_012757 144 15 resemblance resemblance NN 10_1101-2020_03_27_012757 144 16 of of IN 10_1101-2020_03_27_012757 144 17 some some DT 10_1101-2020_03_27_012757 144 18 lines line NNS 10_1101-2020_03_27_012757 144 19 to to IN 10_1101-2020_03_27_012757 144 20 LUSC LUSC NNP 10_1101-2020_03_27_012757 144 21 subtypes subtype NNS 10_1101-2020_03_27_012757 144 22 . . . 10_1101-2020_03_27_012757 145 1 For for IN 10_1101-2020_03_27_012757 145 2 example example NN 10_1101-2020_03_27_012757 145 3 , , , 10_1101-2020_03_27_012757 145 4 HCC-95 hcc-95 NN 10_1101-2020_03_27_012757 145 5 , , , 10_1101-2020_03_27_012757 145 6 328 328 CD 10_1101-2020_03_27_012757 145 7 previously previously RB 10_1101-2020_03_27_012757 145 8 been be VBN 10_1101-2020_03_27_012757 145 9 characterized characterize VBN 10_1101-2020_03_27_012757 145 10 as as IN 10_1101-2020_03_27_012757 145 11 classical28,57 classical28,57 NNP 10_1101-2020_03_27_012757 145 12 , , , 10_1101-2020_03_27_012757 145 13 had have VBD 10_1101-2020_03_27_012757 145 14 a a DT 10_1101-2020_03_27_012757 145 15 maximum maximum JJ 10_1101-2020_03_27_012757 145 16 CCN CCN NNP 10_1101-2020_03_27_012757 145 17 score score NN 10_1101-2020_03_27_012757 145 18 in in IN 10_1101-2020_03_27_012757 145 19 the the DT 10_1101-2020_03_27_012757 145 20 classical classical JJ 10_1101-2020_03_27_012757 145 21 329 329 CD 10_1101-2020_03_27_012757 145 22 subtype subtype NN 10_1101-2020_03_27_012757 145 23 ( ( -LRB- 10_1101-2020_03_27_012757 145 24 0.429 0.429 CD 10_1101-2020_03_27_012757 145 25 ) ) -RRB- 10_1101-2020_03_27_012757 145 26 . . . 10_1101-2020_03_27_012757 146 1 Similarly similarly RB 10_1101-2020_03_27_012757 146 2 , , , 10_1101-2020_03_27_012757 146 3 LUDLU-1 LUDLU-1 NNP 10_1101-2020_03_27_012757 146 4 and and CC 10_1101-2020_03_27_012757 146 5 EPLC-272H eplc-272h JJ 10_1101-2020_03_27_012757 146 6 , , , 10_1101-2020_03_27_012757 146 7 previously previously RB 10_1101-2020_03_27_012757 146 8 reported report VBN 10_1101-2020_03_27_012757 146 9 as as IN 10_1101-2020_03_27_012757 146 10 classical57 classical57 NNPS 10_1101-2020_03_27_012757 146 11 and and CC 10_1101-2020_03_27_012757 146 12 330 330 CD 10_1101-2020_03_27_012757 146 13 basal57 basal57 NNS 10_1101-2020_03_27_012757 146 14 respectively respectively RB 10_1101-2020_03_27_012757 146 15 , , , 10_1101-2020_03_27_012757 146 16 had have VBD 10_1101-2020_03_27_012757 146 17 maximal maximal JJ 10_1101-2020_03_27_012757 146 18 tumor tumor NN 10_1101-2020_03_27_012757 146 19 subtype subtype NN 10_1101-2020_03_27_012757 146 20 CCN CCN NNP 10_1101-2020_03_27_012757 146 21 scores score NNS 10_1101-2020_03_27_012757 146 22 for for IN 10_1101-2020_03_27_012757 146 23 these these DT 10_1101-2020_03_27_012757 146 24 sub sub NN 10_1101-2020_03_27_012757 146 25 - - NNS 10_1101-2020_03_27_012757 146 26 types type NNS 10_1101-2020_03_27_012757 146 27 ( ( -LRB- 10_1101-2020_03_27_012757 146 28 0.323 0.323 CD 10_1101-2020_03_27_012757 146 29 and and CC 10_1101-2020_03_27_012757 146 30 331 331 CD 10_1101-2020_03_27_012757 146 31 0.256 0.256 CD 10_1101-2020_03_27_012757 146 32 ) ) -RRB- 10_1101-2020_03_27_012757 146 33 ( ( -LRB- 10_1101-2020_03_27_012757 146 34 Fig fig NN 10_1101-2020_03_27_012757 146 35 4B 4b NN 10_1101-2020_03_27_012757 146 36 , , , 10_1101-2020_03_27_012757 146 37 Supp Supp NNP 10_1101-2020_03_27_012757 146 38 Tab Tab NNP 10_1101-2020_03_27_012757 146 39 2 2 CD 10_1101-2020_03_27_012757 146 40 ) ) -RRB- 10_1101-2020_03_27_012757 146 41 despite despite IN 10_1101-2020_03_27_012757 146 42 classified classify VBN 10_1101-2020_03_27_012757 146 43 as as IN 10_1101-2020_03_27_012757 146 44 Unknown unknown JJ 10_1101-2020_03_27_012757 146 45 . . . 10_1101-2020_03_27_012757 147 1 Lastly lastly RB 10_1101-2020_03_27_012757 147 2 , , , 10_1101-2020_03_27_012757 147 3 the the DT 10_1101-2020_03_27_012757 147 4 LUAD luad JJ 10_1101-2020_03_27_012757 147 5 cell cell NN 10_1101-2020_03_27_012757 147 6 lines line NNS 10_1101-2020_03_27_012757 147 7 that that IN 10_1101-2020_03_27_012757 147 8 332 332 CD 10_1101-2020_03_27_012757 147 9 were be VBD 10_1101-2020_03_27_012757 147 10 classified classify VBN 10_1101-2020_03_27_012757 147 11 as as IN 10_1101-2020_03_27_012757 147 12 a a DT 10_1101-2020_03_27_012757 147 13 subtype subtype NN 10_1101-2020_03_27_012757 147 14 were be VBD 10_1101-2020_03_27_012757 147 15 either either CC 10_1101-2020_03_27_012757 147 16 classified classify VBN 10_1101-2020_03_27_012757 147 17 as as IN 10_1101-2020_03_27_012757 147 18 proximal proximal JJ 10_1101-2020_03_27_012757 147 19 inflammation inflammation NN 10_1101-2020_03_27_012757 147 20 or or CC 10_1101-2020_03_27_012757 147 21 proximal proximal JJ 10_1101-2020_03_27_012757 147 22 333 333 CD 10_1101-2020_03_27_012757 147 23 proliferation proliferation NN 10_1101-2020_03_27_012757 147 24 ( ( -LRB- 10_1101-2020_03_27_012757 147 25 Fig Fig NNP 10_1101-2020_03_27_012757 147 26 4C 4c NN 10_1101-2020_03_27_012757 147 27 ) ) -RRB- 10_1101-2020_03_27_012757 147 28 . . . 10_1101-2020_03_27_012757 148 1 RERF RERF NNP 10_1101-2020_03_27_012757 148 2 - - HYPH 10_1101-2020_03_27_012757 148 3 LC LC NNP 10_1101-2020_03_27_012757 148 4 - - HYPH 10_1101-2020_03_27_012757 148 5 Ad1 Ad1 NNP 10_1101-2020_03_27_012757 148 6 had have VBD 10_1101-2020_03_27_012757 148 7 the the DT 10_1101-2020_03_27_012757 148 8 highest high JJS 10_1101-2020_03_27_012757 148 9 general general JJ 10_1101-2020_03_27_012757 148 10 classification classification NN 10_1101-2020_03_27_012757 148 11 score score NN 10_1101-2020_03_27_012757 148 12 and and CC 10_1101-2020_03_27_012757 148 13 the the DT 10_1101-2020_03_27_012757 148 14 334 334 CD 10_1101-2020_03_27_012757 148 15 highest high JJS 10_1101-2020_03_27_012757 148 16 proximal proximal JJ 10_1101-2020_03_27_012757 148 17 inflammation inflammation NN 10_1101-2020_03_27_012757 148 18 subtype subtype NN 10_1101-2020_03_27_012757 148 19 classification classification NN 10_1101-2020_03_27_012757 148 20 score score NN 10_1101-2020_03_27_012757 148 21 . . . 10_1101-2020_03_27_012757 149 1 Taken take VBN 10_1101-2020_03_27_012757 149 2 together together RB 10_1101-2020_03_27_012757 149 3 , , , 10_1101-2020_03_27_012757 149 4 these these DT 10_1101-2020_03_27_012757 149 5 subtype subtype NN 10_1101-2020_03_27_012757 149 6 335 335 CD 10_1101-2020_03_27_012757 149 7 classification classification NN 10_1101-2020_03_27_012757 149 8 results result NNS 10_1101-2020_03_27_012757 149 9 have have VBP 10_1101-2020_03_27_012757 149 10 revealed reveal VBN 10_1101-2020_03_27_012757 149 11 an an DT 10_1101-2020_03_27_012757 149 12 absence absence NN 10_1101-2020_03_27_012757 149 13 of of IN 10_1101-2020_03_27_012757 149 14 cell cell NN 10_1101-2020_03_27_012757 149 15 lines line NNS 10_1101-2020_03_27_012757 149 16 models model NNS 10_1101-2020_03_27_012757 149 17 for for IN 10_1101-2020_03_27_012757 149 18 basal basal NN 10_1101-2020_03_27_012757 149 19 and and CC 10_1101-2020_03_27_012757 149 20 secretory secretory RB 10_1101-2020_03_27_012757 149 21 336 336 CD 10_1101-2020_03_27_012757 149 22 LUSC LUSC NNP 10_1101-2020_03_27_012757 149 23 , , , 10_1101-2020_03_27_012757 149 24 and and CC 10_1101-2020_03_27_012757 149 25 for for IN 10_1101-2020_03_27_012757 149 26 the the DT 10_1101-2020_03_27_012757 149 27 Terminal Terminal NNP 10_1101-2020_03_27_012757 149 28 respiratory respiratory JJ 10_1101-2020_03_27_012757 149 29 unit unit NN 10_1101-2020_03_27_012757 149 30 ( ( -LRB- 10_1101-2020_03_27_012757 149 31 TRU tru NN 10_1101-2020_03_27_012757 149 32 ) ) -RRB- 10_1101-2020_03_27_012757 149 33 LUAD LUAD NNP 10_1101-2020_03_27_012757 149 34 subtype subtype NN 10_1101-2020_03_27_012757 149 35 . . . 10_1101-2020_03_27_012757 150 1 337 337 CD 10_1101-2020_03_27_012757 150 2 338 338 CD 10_1101-2020_03_27_012757 150 3 Cancer Cancer NNP 10_1101-2020_03_27_012757 150 4 cell cell NN 10_1101-2020_03_27_012757 150 5 lines line NNS 10_1101-2020_03_27_012757 150 6 ’ ’ POS 10_1101-2020_03_27_012757 150 7 popularity popularity NN 10_1101-2020_03_27_012757 150 8 and and CC 10_1101-2020_03_27_012757 150 9 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 150 10 fidelity fidelity NN 10_1101-2020_03_27_012757 150 11 339 339 CD 10_1101-2020_03_27_012757 150 12 Finally finally RB 10_1101-2020_03_27_012757 150 13 , , , 10_1101-2020_03_27_012757 150 14 we -PRON- PRP 10_1101-2020_03_27_012757 150 15 sought seek VBD 10_1101-2020_03_27_012757 150 16 to to TO 10_1101-2020_03_27_012757 150 17 measure measure VB 10_1101-2020_03_27_012757 150 18 the the DT 10_1101-2020_03_27_012757 150 19 extent extent NN 10_1101-2020_03_27_012757 150 20 to to TO 10_1101-2020_03_27_012757 150 21 which which WDT 10_1101-2020_03_27_012757 150 22 cell cell NN 10_1101-2020_03_27_012757 150 23 line line NN 10_1101-2020_03_27_012757 150 24 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 150 25 fidelity fidelity NNP 10_1101-2020_03_27_012757 150 26 related relate VBD 10_1101-2020_03_27_012757 150 27 340 340 CD 10_1101-2020_03_27_012757 150 28 to to TO 10_1101-2020_03_27_012757 150 29 model model NN 10_1101-2020_03_27_012757 150 30 prevalence prevalence NN 10_1101-2020_03_27_012757 150 31 . . . 10_1101-2020_03_27_012757 151 1 We -PRON- PRP 10_1101-2020_03_27_012757 151 2 used use VBD 10_1101-2020_03_27_012757 151 3 the the DT 10_1101-2020_03_27_012757 151 4 number number NN 10_1101-2020_03_27_012757 151 5 of of IN 10_1101-2020_03_27_012757 151 6 papers paper NNS 10_1101-2020_03_27_012757 151 7 in in IN 10_1101-2020_03_27_012757 151 8 which which WDT 10_1101-2020_03_27_012757 151 9 a a DT 10_1101-2020_03_27_012757 151 10 model model NN 10_1101-2020_03_27_012757 151 11 was be VBD 10_1101-2020_03_27_012757 151 12 mentioned mention VBN 10_1101-2020_03_27_012757 151 13 , , , 10_1101-2020_03_27_012757 151 14 341 341 CD 10_1101-2020_03_27_012757 151 15 normalized normalize VBN 10_1101-2020_03_27_012757 151 16 by by IN 10_1101-2020_03_27_012757 151 17 the the DT 10_1101-2020_03_27_012757 151 18 number number NN 10_1101-2020_03_27_012757 151 19 of of IN 10_1101-2020_03_27_012757 151 20 years year NNS 10_1101-2020_03_27_012757 151 21 since since IN 10_1101-2020_03_27_012757 151 22 the the DT 10_1101-2020_03_27_012757 151 23 cell cell NN 10_1101-2020_03_27_012757 151 24 line line NN 10_1101-2020_03_27_012757 151 25 was be VBD 10_1101-2020_03_27_012757 151 26 documented document VBN 10_1101-2020_03_27_012757 151 27 , , , 10_1101-2020_03_27_012757 151 28 as as IN 10_1101-2020_03_27_012757 151 29 a a DT 10_1101-2020_03_27_012757 151 30 rough rough JJ 10_1101-2020_03_27_012757 151 31 342 342 CD 10_1101-2020_03_27_012757 151 32 approximation approximation NN 10_1101-2020_03_27_012757 151 33 of of IN 10_1101-2020_03_27_012757 151 34 model model NN 10_1101-2020_03_27_012757 151 35 prevalence prevalence NN 10_1101-2020_03_27_012757 151 36 . . . 10_1101-2020_03_27_012757 152 1 To to TO 10_1101-2020_03_27_012757 152 2 explore explore VB 10_1101-2020_03_27_012757 152 3 this this DT 10_1101-2020_03_27_012757 152 4 relationship relationship NN 10_1101-2020_03_27_012757 152 5 , , , 10_1101-2020_03_27_012757 152 6 we -PRON- PRP 10_1101-2020_03_27_012757 152 7 plotted plot VBD 10_1101-2020_03_27_012757 152 8 the the DT 10_1101-2020_03_27_012757 152 9 normalized normalized JJ 10_1101-2020_03_27_012757 152 10 343 343 CD 10_1101-2020_03_27_012757 152 11 citation citation NN 10_1101-2020_03_27_012757 152 12 count count NN 10_1101-2020_03_27_012757 152 13 versus versus IN 10_1101-2020_03_27_012757 152 14 general general JJ 10_1101-2020_03_27_012757 152 15 classification classification NN 10_1101-2020_03_27_012757 152 16 score score NN 10_1101-2020_03_27_012757 152 17 , , , 10_1101-2020_03_27_012757 152 18 labeling label VBG 10_1101-2020_03_27_012757 152 19 the the DT 10_1101-2020_03_27_012757 152 20 highest highest RBS 10_1101-2020_03_27_012757 152 21 cited cited JJ 10_1101-2020_03_27_012757 152 22 and and CC 10_1101-2020_03_27_012757 152 23 highest high JJS 10_1101-2020_03_27_012757 152 24 344 344 CD 10_1101-2020_03_27_012757 152 25 .CC .CC NFP 10_1101-2020_03_27_012757 152 26 - - HYPH 10_1101-2020_03_27_012757 152 27 BY by IN 10_1101-2020_03_27_012757 152 28 - - HYPH 10_1101-2020_03_27_012757 152 29 NC NC NNP 10_1101-2020_03_27_012757 152 30 - - HYPH 10_1101-2020_03_27_012757 152 31 ND ND NNP 10_1101-2020_03_27_012757 152 32 4.0 4.0 CD 10_1101-2020_03_27_012757 152 33 International International NNP 10_1101-2020_03_27_012757 152 34 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 152 35 under under IN 10_1101-2020_03_27_012757 152 36 a a DT 10_1101-2020_03_27_012757 152 37 ( ( -LRB- 10_1101-2020_03_27_012757 152 38 which which WDT 10_1101-2020_03_27_012757 152 39 was be VBD 10_1101-2020_03_27_012757 152 40 not not RB 10_1101-2020_03_27_012757 152 41 certified certify VBN 10_1101-2020_03_27_012757 152 42 by by IN 10_1101-2020_03_27_012757 152 43 peer peer NN 10_1101-2020_03_27_012757 152 44 review review NN 10_1101-2020_03_27_012757 152 45 ) ) -RRB- 10_1101-2020_03_27_012757 152 46 is be VBZ 10_1101-2020_03_27_012757 152 47 the the DT 10_1101-2020_03_27_012757 152 48 author author NN 10_1101-2020_03_27_012757 152 49 / / SYM 10_1101-2020_03_27_012757 152 50 funder funder NN 10_1101-2020_03_27_012757 152 51 , , , 10_1101-2020_03_27_012757 152 52 who who WP 10_1101-2020_03_27_012757 152 53 has have VBZ 10_1101-2020_03_27_012757 152 54 granted grant VBN 10_1101-2020_03_27_012757 152 55 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 152 56 a a DT 10_1101-2020_03_27_012757 152 57 license license NN 10_1101-2020_03_27_012757 152 58 to to TO 10_1101-2020_03_27_012757 152 59 display display VB 10_1101-2020_03_27_012757 152 60 the the DT 10_1101-2020_03_27_012757 152 61 preprint preprint NN 10_1101-2020_03_27_012757 152 62 in in IN 10_1101-2020_03_27_012757 152 63 perpetuity perpetuity NN 10_1101-2020_03_27_012757 152 64 . . . 10_1101-2020_03_27_012757 153 1 It -PRON- PRP 10_1101-2020_03_27_012757 153 2 is be VBZ 10_1101-2020_03_27_012757 153 3 made make VBN 10_1101-2020_03_27_012757 153 4 The the DT 10_1101-2020_03_27_012757 153 5 copyright copyright NN 10_1101-2020_03_27_012757 153 6 holder holder NN 10_1101-2020_03_27_012757 153 7 for for IN 10_1101-2020_03_27_012757 153 8 this this DT 10_1101-2020_03_27_012757 153 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 153 10 version version NN 10_1101-2020_03_27_012757 153 11 posted post VBD 10_1101-2020_03_27_012757 153 12 January January NNP 10_1101-2020_03_27_012757 153 13 9 9 CD 10_1101-2020_03_27_012757 153 14 , , , 10_1101-2020_03_27_012757 153 15 2021 2021 CD 10_1101-2020_03_27_012757 153 16 . . . 10_1101-2020_03_27_012757 153 17 ; ; : 10_1101-2020_03_27_012757 153 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 153 19 : : : 10_1101-2020_03_27_012757 153 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 153 21 preprint preprint NN 10_1101-2020_03_27_012757 153 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 153 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 153 24 13 13 CD 10_1101-2020_03_27_012757 153 25 classified classified JJ 10_1101-2020_03_27_012757 153 26 cell cell NN 10_1101-2020_03_27_012757 153 27 lines line NNS 10_1101-2020_03_27_012757 153 28 from from IN 10_1101-2020_03_27_012757 153 29 each each DT 10_1101-2020_03_27_012757 153 30 general general JJ 10_1101-2020_03_27_012757 153 31 tumor tumor NN 10_1101-2020_03_27_012757 153 32 type type NN 10_1101-2020_03_27_012757 153 33 ( ( -LRB- 10_1101-2020_03_27_012757 153 34 Fig Fig NNP 10_1101-2020_03_27_012757 153 35 4D 4d NN 10_1101-2020_03_27_012757 153 36 ) ) -RRB- 10_1101-2020_03_27_012757 153 37 . . . 10_1101-2020_03_27_012757 154 1 For for IN 10_1101-2020_03_27_012757 154 2 most most JJS 10_1101-2020_03_27_012757 154 3 of of IN 10_1101-2020_03_27_012757 154 4 the the DT 10_1101-2020_03_27_012757 154 5 general general JJ 10_1101-2020_03_27_012757 154 6 tumor tumor NN 10_1101-2020_03_27_012757 154 7 types type NNS 10_1101-2020_03_27_012757 154 8 , , , 10_1101-2020_03_27_012757 154 9 345 345 CD 10_1101-2020_03_27_012757 154 10 the the DT 10_1101-2020_03_27_012757 154 11 highest highest RBS 10_1101-2020_03_27_012757 154 12 cited cited JJ 10_1101-2020_03_27_012757 154 13 cell cell NN 10_1101-2020_03_27_012757 154 14 line line NN 10_1101-2020_03_27_012757 154 15 is be VBZ 10_1101-2020_03_27_012757 154 16 not not RB 10_1101-2020_03_27_012757 154 17 the the DT 10_1101-2020_03_27_012757 154 18 highest high JJS 10_1101-2020_03_27_012757 154 19 classified classified JJ 10_1101-2020_03_27_012757 154 20 cell cell NN 10_1101-2020_03_27_012757 154 21 line line NN 10_1101-2020_03_27_012757 154 22 except except IN 10_1101-2020_03_27_012757 154 23 for for IN 10_1101-2020_03_27_012757 154 24 Hep Hep NNP 10_1101-2020_03_27_012757 154 25 G2 G2 NNP 10_1101-2020_03_27_012757 154 26 , , , 10_1101-2020_03_27_012757 154 27 AGS AGS NNP 10_1101-2020_03_27_012757 154 28 and and CC 10_1101-2020_03_27_012757 154 29 ML-346 ML-346 NNP 10_1101-2020_03_27_012757 154 30 1 1 CD 10_1101-2020_03_27_012757 154 31 , , , 10_1101-2020_03_27_012757 154 32 representing represent VBG 10_1101-2020_03_27_012757 154 33 liver liver NN 10_1101-2020_03_27_012757 154 34 hepatocellular hepatocellular NN 10_1101-2020_03_27_012757 154 35 carcinoma carcinoma NNP 10_1101-2020_03_27_012757 154 36 ( ( -LRB- 10_1101-2020_03_27_012757 154 37 LIHC LIHC NNP 10_1101-2020_03_27_012757 154 38 ) ) -RRB- 10_1101-2020_03_27_012757 154 39 , , , 10_1101-2020_03_27_012757 154 40 stomach stomach NN 10_1101-2020_03_27_012757 154 41 adenocarcinoma adenocarcinoma NN 10_1101-2020_03_27_012757 154 42 ( ( -LRB- 10_1101-2020_03_27_012757 154 43 STAD STAD NNP 10_1101-2020_03_27_012757 154 44 ) ) -RRB- 10_1101-2020_03_27_012757 154 45 , , , 10_1101-2020_03_27_012757 154 46 and and CC 10_1101-2020_03_27_012757 154 47 347 347 CD 10_1101-2020_03_27_012757 154 48 thyroid thyroid NN 10_1101-2020_03_27_012757 154 49 carcinoma carcinoma NN 10_1101-2020_03_27_012757 154 50 ( ( -LRB- 10_1101-2020_03_27_012757 154 51 THCA THCA NNP 10_1101-2020_03_27_012757 154 52 ) ) -RRB- 10_1101-2020_03_27_012757 154 53 , , , 10_1101-2020_03_27_012757 154 54 respectively respectively RB 10_1101-2020_03_27_012757 154 55 . . . 10_1101-2020_03_27_012757 155 1 On on IN 10_1101-2020_03_27_012757 155 2 the the DT 10_1101-2020_03_27_012757 155 3 other other JJ 10_1101-2020_03_27_012757 155 4 hand hand NN 10_1101-2020_03_27_012757 155 5 , , , 10_1101-2020_03_27_012757 155 6 the the DT 10_1101-2020_03_27_012757 155 7 general general JJ 10_1101-2020_03_27_012757 155 8 scores score NNS 10_1101-2020_03_27_012757 155 9 of of IN 10_1101-2020_03_27_012757 155 10 the the DT 10_1101-2020_03_27_012757 155 11 highest high JJS 10_1101-2020_03_27_012757 155 12 348 348 CD 10_1101-2020_03_27_012757 155 13 cited cite VBN 10_1101-2020_03_27_012757 155 14 cell cell NN 10_1101-2020_03_27_012757 155 15 lines line NNS 10_1101-2020_03_27_012757 155 16 representing represent VBG 10_1101-2020_03_27_012757 155 17 BLCA BLCA NNP 10_1101-2020_03_27_012757 155 18 ( ( -LRB- 10_1101-2020_03_27_012757 155 19 T24 T24 NNP 10_1101-2020_03_27_012757 155 20 ) ) -RRB- 10_1101-2020_03_27_012757 155 21 , , , 10_1101-2020_03_27_012757 155 22 BRCA BRCA NNP 10_1101-2020_03_27_012757 155 23 ( ( -LRB- 10_1101-2020_03_27_012757 155 24 MDA MDA NNP 10_1101-2020_03_27_012757 155 25 - - HYPH 10_1101-2020_03_27_012757 155 26 MB-231 MB-231 NNP 10_1101-2020_03_27_012757 155 27 ) ) -RRB- 10_1101-2020_03_27_012757 155 28 , , , 10_1101-2020_03_27_012757 155 29 and and CC 10_1101-2020_03_27_012757 155 30 PRAD PRAD NNP 10_1101-2020_03_27_012757 155 31 ( ( -LRB- 10_1101-2020_03_27_012757 155 32 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 155 33 ) ) -RRB- 10_1101-2020_03_27_012757 155 34 fall fall VBP 10_1101-2020_03_27_012757 155 35 below below IN 10_1101-2020_03_27_012757 155 36 349 349 CD 10_1101-2020_03_27_012757 155 37 the the DT 10_1101-2020_03_27_012757 155 38 classification classification NN 10_1101-2020_03_27_012757 155 39 threshold threshold NN 10_1101-2020_03_27_012757 155 40 of of IN 10_1101-2020_03_27_012757 155 41 0.25 0.25 CD 10_1101-2020_03_27_012757 155 42 . . . 10_1101-2020_03_27_012757 156 1 Notably notably RB 10_1101-2020_03_27_012757 156 2 , , , 10_1101-2020_03_27_012757 156 3 each each DT 10_1101-2020_03_27_012757 156 4 of of IN 10_1101-2020_03_27_012757 156 5 these these DT 10_1101-2020_03_27_012757 156 6 tumor tumor NN 10_1101-2020_03_27_012757 156 7 types type NNS 10_1101-2020_03_27_012757 156 8 have have VBP 10_1101-2020_03_27_012757 156 9 other other JJ 10_1101-2020_03_27_012757 156 10 lines line NNS 10_1101-2020_03_27_012757 156 11 with with IN 10_1101-2020_03_27_012757 156 12 350 350 CD 10_1101-2020_03_27_012757 156 13 scores score NNS 10_1101-2020_03_27_012757 156 14 exceeding exceed VBG 10_1101-2020_03_27_012757 156 15 0.5 0.5 CD 10_1101-2020_03_27_012757 156 16 , , , 10_1101-2020_03_27_012757 156 17 which which WDT 10_1101-2020_03_27_012757 156 18 should should MD 10_1101-2020_03_27_012757 156 19 be be VB 10_1101-2020_03_27_012757 156 20 considered consider VBN 10_1101-2020_03_27_012757 156 21 as as IN 10_1101-2020_03_27_012757 156 22 more more RBR 10_1101-2020_03_27_012757 156 23 faithful faithful JJ 10_1101-2020_03_27_012757 156 24 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 156 25 models model NNS 10_1101-2020_03_27_012757 156 26 when when WRB 10_1101-2020_03_27_012757 156 27 351 351 CD 10_1101-2020_03_27_012757 156 28 selecting select VBG 10_1101-2020_03_27_012757 156 29 lines line NNS 10_1101-2020_03_27_012757 156 30 for for IN 10_1101-2020_03_27_012757 156 31 a a DT 10_1101-2020_03_27_012757 156 32 study study NN 10_1101-2020_03_27_012757 156 33 ( ( -LRB- 10_1101-2020_03_27_012757 156 34 Supp Supp NNP 10_1101-2020_03_27_012757 156 35 Tab Tab NNP 10_1101-2020_03_27_012757 156 36 1 1 CD 10_1101-2020_03_27_012757 156 37 and and CC 10_1101-2020_03_27_012757 156 38 352 352 CD 10_1101-2020_03_27_012757 156 39 http://www.cahanlab.org/resources/cancerCellNet_results/ http://www.cahanlab.org/resources/cancerCellNet_results/ NNS 10_1101-2020_03_27_012757 156 40 ) ) -RRB- 10_1101-2020_03_27_012757 156 41 . . . 10_1101-2020_03_27_012757 157 1 353 353 CD 10_1101-2020_03_27_012757 157 2 354 354 CD 10_1101-2020_03_27_012757 157 3 Evaluation Evaluation NNP 10_1101-2020_03_27_012757 157 4 of of IN 10_1101-2020_03_27_012757 157 5 patient patient JJ 10_1101-2020_03_27_012757 157 6 derived derive VBN 10_1101-2020_03_27_012757 157 7 xenografts xenografts NNP 10_1101-2020_03_27_012757 157 8 355 355 CD 10_1101-2020_03_27_012757 157 9 Next Next NNP 10_1101-2020_03_27_012757 157 10 , , , 10_1101-2020_03_27_012757 157 11 we -PRON- PRP 10_1101-2020_03_27_012757 157 12 sought seek VBD 10_1101-2020_03_27_012757 157 13 to to TO 10_1101-2020_03_27_012757 157 14 evaluate evaluate VB 10_1101-2020_03_27_012757 157 15 a a DT 10_1101-2020_03_27_012757 157 16 more more RBR 10_1101-2020_03_27_012757 157 17 recent recent JJ 10_1101-2020_03_27_012757 157 18 class class NN 10_1101-2020_03_27_012757 157 19 of of IN 10_1101-2020_03_27_012757 157 20 cancer cancer NN 10_1101-2020_03_27_012757 157 21 models model NNS 10_1101-2020_03_27_012757 157 22 : : : 10_1101-2020_03_27_012757 157 23 PDX PDX NNP 10_1101-2020_03_27_012757 157 24 . . . 10_1101-2020_03_27_012757 158 1 To to TO 10_1101-2020_03_27_012757 158 2 do do VB 10_1101-2020_03_27_012757 158 3 so so RB 10_1101-2020_03_27_012757 158 4 , , , 10_1101-2020_03_27_012757 158 5 we -PRON- PRP 10_1101-2020_03_27_012757 158 6 356 356 CD 10_1101-2020_03_27_012757 158 7 subjected subject VBD 10_1101-2020_03_27_012757 158 8 the the DT 10_1101-2020_03_27_012757 158 9 RNA RNA NNP 10_1101-2020_03_27_012757 158 10 - - HYPH 10_1101-2020_03_27_012757 158 11 seq seq NN 10_1101-2020_03_27_012757 158 12 expression expression NN 10_1101-2020_03_27_012757 158 13 profiles profile NNS 10_1101-2020_03_27_012757 158 14 of of IN 10_1101-2020_03_27_012757 158 15 415 415 CD 10_1101-2020_03_27_012757 158 16 PDX PDX NNP 10_1101-2020_03_27_012757 158 17 models model NNS 10_1101-2020_03_27_012757 158 18 from from IN 10_1101-2020_03_27_012757 158 19 13 13 CD 10_1101-2020_03_27_012757 158 20 different different JJ 10_1101-2020_03_27_012757 158 21 types type NNS 10_1101-2020_03_27_012757 158 22 of of IN 10_1101-2020_03_27_012757 158 23 cancer cancer NN 10_1101-2020_03_27_012757 158 24 357 357 CD 10_1101-2020_03_27_012757 158 25 types type NNS 10_1101-2020_03_27_012757 158 26 generated generate VBD 10_1101-2020_03_27_012757 158 27 previously20 previously20 NNP 10_1101-2020_03_27_012757 158 28 to to IN 10_1101-2020_03_27_012757 158 29 CCN CCN NNP 10_1101-2020_03_27_012757 158 30 . . . 10_1101-2020_03_27_012757 159 1 Similar similar JJ 10_1101-2020_03_27_012757 159 2 to to IN 10_1101-2020_03_27_012757 159 3 the the DT 10_1101-2020_03_27_012757 159 4 results result NNS 10_1101-2020_03_27_012757 159 5 of of IN 10_1101-2020_03_27_012757 159 6 CCLs ccl NNS 10_1101-2020_03_27_012757 159 7 , , , 10_1101-2020_03_27_012757 159 8 the the DT 10_1101-2020_03_27_012757 159 9 PDXs pdx NNS 10_1101-2020_03_27_012757 159 10 exhibited exhibit VBD 10_1101-2020_03_27_012757 159 11 a a DT 10_1101-2020_03_27_012757 159 12 wide wide JJ 10_1101-2020_03_27_012757 159 13 358 358 CD 10_1101-2020_03_27_012757 159 14 range range NN 10_1101-2020_03_27_012757 159 15 of of IN 10_1101-2020_03_27_012757 159 16 classification classification NN 10_1101-2020_03_27_012757 159 17 scores score NNS 10_1101-2020_03_27_012757 159 18 ( ( -LRB- 10_1101-2020_03_27_012757 159 19 Fig fig NN 10_1101-2020_03_27_012757 159 20 5A 5a RB 10_1101-2020_03_27_012757 159 21 , , , 10_1101-2020_03_27_012757 159 22 Supp Supp NNP 10_1101-2020_03_27_012757 159 23 Tab Tab NNP 10_1101-2020_03_27_012757 159 24 3 3 CD 10_1101-2020_03_27_012757 159 25 ) ) -RRB- 10_1101-2020_03_27_012757 159 26 . . . 10_1101-2020_03_27_012757 160 1 By by IN 10_1101-2020_03_27_012757 160 2 categorizing categorize VBG 10_1101-2020_03_27_012757 160 3 the the DT 10_1101-2020_03_27_012757 160 4 CCN CCN NNP 10_1101-2020_03_27_012757 160 5 scores score NNS 10_1101-2020_03_27_012757 160 6 of of IN 10_1101-2020_03_27_012757 160 7 PDX PDX NNP 10_1101-2020_03_27_012757 160 8 359 359 CD 10_1101-2020_03_27_012757 160 9 based base VBN 10_1101-2020_03_27_012757 160 10 on on IN 10_1101-2020_03_27_012757 160 11 the the DT 10_1101-2020_03_27_012757 160 12 proportion proportion NN 10_1101-2020_03_27_012757 160 13 of of IN 10_1101-2020_03_27_012757 160 14 samples sample NNS 10_1101-2020_03_27_012757 160 15 associated associate VBN 10_1101-2020_03_27_012757 160 16 with with IN 10_1101-2020_03_27_012757 160 17 each each DT 10_1101-2020_03_27_012757 160 18 tumor tumor NN 10_1101-2020_03_27_012757 160 19 type type NN 10_1101-2020_03_27_012757 160 20 that that WDT 10_1101-2020_03_27_012757 160 21 were be VBD 10_1101-2020_03_27_012757 160 22 correctly correctly RB 10_1101-2020_03_27_012757 160 23 360 360 CD 10_1101-2020_03_27_012757 160 24 classified classify VBD 10_1101-2020_03_27_012757 160 25 , , , 10_1101-2020_03_27_012757 160 26 we -PRON- PRP 10_1101-2020_03_27_012757 160 27 found find VBD 10_1101-2020_03_27_012757 160 28 that that IN 10_1101-2020_03_27_012757 160 29 SARC SARC NNP 10_1101-2020_03_27_012757 160 30 , , , 10_1101-2020_03_27_012757 160 31 SKCM SKCM NNP 10_1101-2020_03_27_012757 160 32 , , , 10_1101-2020_03_27_012757 160 33 COAD_READ COAD_READ NNS 10_1101-2020_03_27_012757 160 34 and and CC 10_1101-2020_03_27_012757 160 35 BRCA BRCA NNP 10_1101-2020_03_27_012757 160 36 have have VBP 10_1101-2020_03_27_012757 160 37 higher high JJR 10_1101-2020_03_27_012757 160 38 proportion proportion NN 10_1101-2020_03_27_012757 160 39 of of IN 10_1101-2020_03_27_012757 160 40 361 361 CD 10_1101-2020_03_27_012757 160 41 correctly correctly RB 10_1101-2020_03_27_012757 160 42 classified classify VBN 10_1101-2020_03_27_012757 160 43 PDX pdx NN 10_1101-2020_03_27_012757 160 44 than than IN 10_1101-2020_03_27_012757 160 45 those those DT 10_1101-2020_03_27_012757 160 46 of of IN 10_1101-2020_03_27_012757 160 47 other other JJ 10_1101-2020_03_27_012757 160 48 cancer cancer NN 10_1101-2020_03_27_012757 160 49 categories category NNS 10_1101-2020_03_27_012757 160 50 ( ( -LRB- 10_1101-2020_03_27_012757 160 51 Fig Fig NNP 10_1101-2020_03_27_012757 160 52 5B 5b NN 10_1101-2020_03_27_012757 160 53 ) ) -RRB- 10_1101-2020_03_27_012757 160 54 . . . 10_1101-2020_03_27_012757 161 1 In in IN 10_1101-2020_03_27_012757 161 2 contrast contrast NN 10_1101-2020_03_27_012757 161 3 to to IN 10_1101-2020_03_27_012757 161 4 CCLs CCLs NNP 10_1101-2020_03_27_012757 161 5 , , , 10_1101-2020_03_27_012757 161 6 we -PRON- PRP 10_1101-2020_03_27_012757 161 7 362 362 CD 10_1101-2020_03_27_012757 161 8 found find VBD 10_1101-2020_03_27_012757 161 9 a a DT 10_1101-2020_03_27_012757 161 10 higher high JJR 10_1101-2020_03_27_012757 161 11 proportion proportion NN 10_1101-2020_03_27_012757 161 12 of of IN 10_1101-2020_03_27_012757 161 13 correctly correctly RB 10_1101-2020_03_27_012757 161 14 classified classify VBN 10_1101-2020_03_27_012757 161 15 PDX PDX NNP 10_1101-2020_03_27_012757 161 16 in in IN 10_1101-2020_03_27_012757 161 17 STAD STAD NNP 10_1101-2020_03_27_012757 161 18 , , , 10_1101-2020_03_27_012757 161 19 PAAD PAAD NNP 10_1101-2020_03_27_012757 161 20 and and CC 10_1101-2020_03_27_012757 161 21 KIRC KIRC NNP 10_1101-2020_03_27_012757 161 22 ( ( -LRB- 10_1101-2020_03_27_012757 161 23 Fig Fig NNP 10_1101-2020_03_27_012757 161 24 5B 5b NN 10_1101-2020_03_27_012757 161 25 ) ) -RRB- 10_1101-2020_03_27_012757 161 26 . . . 10_1101-2020_03_27_012757 162 1 363 363 CD 10_1101-2020_03_27_012757 162 2 However however RB 10_1101-2020_03_27_012757 162 3 , , , 10_1101-2020_03_27_012757 162 4 similar similar JJ 10_1101-2020_03_27_012757 162 5 to to IN 10_1101-2020_03_27_012757 162 6 CCLs CCLs NNP 10_1101-2020_03_27_012757 162 7 , , , 10_1101-2020_03_27_012757 162 8 no no DT 10_1101-2020_03_27_012757 162 9 ESCA ESCA NNP 10_1101-2020_03_27_012757 162 10 PDXs pdx NNS 10_1101-2020_03_27_012757 162 11 were be VBD 10_1101-2020_03_27_012757 162 12 classified classify VBN 10_1101-2020_03_27_012757 162 13 as as IN 10_1101-2020_03_27_012757 162 14 such such JJ 10_1101-2020_03_27_012757 162 15 . . . 10_1101-2020_03_27_012757 163 1 This this DT 10_1101-2020_03_27_012757 163 2 held hold VBN 10_1101-2020_03_27_012757 163 3 true true JJ 10_1101-2020_03_27_012757 163 4 when when WRB 10_1101-2020_03_27_012757 163 5 we -PRON- PRP 10_1101-2020_03_27_012757 163 6 364 364 CD 10_1101-2020_03_27_012757 163 7 performed perform VBN 10_1101-2020_03_27_012757 163 8 subtype subtype NN 10_1101-2020_03_27_012757 163 9 classification classification NN 10_1101-2020_03_27_012757 163 10 on on IN 10_1101-2020_03_27_012757 163 11 PDX PDX NNP 10_1101-2020_03_27_012757 163 12 samples sample NNS 10_1101-2020_03_27_012757 163 13 : : : 10_1101-2020_03_27_012757 163 14 none none NN 10_1101-2020_03_27_012757 163 15 of of IN 10_1101-2020_03_27_012757 163 16 the the DT 10_1101-2020_03_27_012757 163 17 PDX PDX NNP 10_1101-2020_03_27_012757 163 18 in in IN 10_1101-2020_03_27_012757 163 19 ESCA ESCA NNP 10_1101-2020_03_27_012757 163 20 were be VBD 10_1101-2020_03_27_012757 163 21 classified classify VBN 10_1101-2020_03_27_012757 163 22 as as IN 10_1101-2020_03_27_012757 163 23 365 365 CD 10_1101-2020_03_27_012757 163 24 any any DT 10_1101-2020_03_27_012757 163 25 of of IN 10_1101-2020_03_27_012757 163 26 the the DT 10_1101-2020_03_27_012757 163 27 ESCA ESCA NNP 10_1101-2020_03_27_012757 163 28 subtypes subtype NNS 10_1101-2020_03_27_012757 163 29 ( ( -LRB- 10_1101-2020_03_27_012757 163 30 Supp Supp NNP 10_1101-2020_03_27_012757 163 31 Tab Tab NNP 10_1101-2020_03_27_012757 163 32 4 4 CD 10_1101-2020_03_27_012757 163 33 ) ) -RRB- 10_1101-2020_03_27_012757 163 34 . . . 10_1101-2020_03_27_012757 164 1 UCEC UCEC NNP 10_1101-2020_03_27_012757 164 2 PDXs pdx NNS 10_1101-2020_03_27_012757 164 3 had have VBD 10_1101-2020_03_27_012757 164 4 both both DT 10_1101-2020_03_27_012757 164 5 endometrioid endometrioid NN 10_1101-2020_03_27_012757 164 6 subtypes subtype NNS 10_1101-2020_03_27_012757 164 7 , , , 10_1101-2020_03_27_012757 164 8 serous serous JJ 10_1101-2020_03_27_012757 164 9 366 366 CD 10_1101-2020_03_27_012757 164 10 subtypes subtype NNS 10_1101-2020_03_27_012757 164 11 , , , 10_1101-2020_03_27_012757 164 12 and and CC 10_1101-2020_03_27_012757 164 13 mixed mixed JJ 10_1101-2020_03_27_012757 164 14 subtypes subtype NNS 10_1101-2020_03_27_012757 164 15 , , , 10_1101-2020_03_27_012757 164 16 which which WDT 10_1101-2020_03_27_012757 164 17 provided provide VBD 10_1101-2020_03_27_012757 164 18 a a DT 10_1101-2020_03_27_012757 164 19 broader broad JJR 10_1101-2020_03_27_012757 164 20 representation representation NN 10_1101-2020_03_27_012757 164 21 than than IN 10_1101-2020_03_27_012757 164 22 CCLs CCLs NNP 10_1101-2020_03_27_012757 164 23 ( ( -LRB- 10_1101-2020_03_27_012757 164 24 Fig fig NN 10_1101-2020_03_27_012757 164 25 5C 5c NN 10_1101-2020_03_27_012757 164 26 ) ) -RRB- 10_1101-2020_03_27_012757 164 27 . . . 10_1101-2020_03_27_012757 165 1 367 367 CD 10_1101-2020_03_27_012757 165 2 Several several JJ 10_1101-2020_03_27_012757 165 3 LUSC LUSC NNP 10_1101-2020_03_27_012757 165 4 PDXs pdx NNS 10_1101-2020_03_27_012757 165 5 that that WDT 10_1101-2020_03_27_012757 165 6 were be VBD 10_1101-2020_03_27_012757 165 7 classified classify VBN 10_1101-2020_03_27_012757 165 8 as as IN 10_1101-2020_03_27_012757 165 9 a a DT 10_1101-2020_03_27_012757 165 10 subtype subtype NN 10_1101-2020_03_27_012757 165 11 were be VBD 10_1101-2020_03_27_012757 165 12 also also RB 10_1101-2020_03_27_012757 165 13 classified classify VBN 10_1101-2020_03_27_012757 165 14 as as IN 10_1101-2020_03_27_012757 165 15 Head Head NNP 10_1101-2020_03_27_012757 165 16 and and CC 10_1101-2020_03_27_012757 165 17 Neck Neck NNP 10_1101-2020_03_27_012757 165 18 368 368 CD 10_1101-2020_03_27_012757 165 19 squamous squamous JJ 10_1101-2020_03_27_012757 165 20 cell cell NN 10_1101-2020_03_27_012757 165 21 carcinoma carcinoma NN 10_1101-2020_03_27_012757 165 22 ( ( -LRB- 10_1101-2020_03_27_012757 165 23 HNSC HNSC NNP 10_1101-2020_03_27_012757 165 24 ) ) -RRB- 10_1101-2020_03_27_012757 165 25 or or CC 10_1101-2020_03_27_012757 165 26 mix mix VB 10_1101-2020_03_27_012757 165 27 HNSC HNSC NNP 10_1101-2020_03_27_012757 165 28 and and CC 10_1101-2020_03_27_012757 165 29 LUSC LUSC NNP 10_1101-2020_03_27_012757 165 30 ( ( -LRB- 10_1101-2020_03_27_012757 165 31 Fig Fig NNP 10_1101-2020_03_27_012757 165 32 5D 5d NN 10_1101-2020_03_27_012757 165 33 ) ) -RRB- 10_1101-2020_03_27_012757 165 34 . . . 10_1101-2020_03_27_012757 166 1 This this DT 10_1101-2020_03_27_012757 166 2 could could MD 10_1101-2020_03_27_012757 166 3 be be VB 10_1101-2020_03_27_012757 166 4 due due IN 10_1101-2020_03_27_012757 166 5 to to IN 10_1101-2020_03_27_012757 166 6 the the DT 10_1101-2020_03_27_012757 166 7 369 369 CD 10_1101-2020_03_27_012757 166 8 similarity similarity NN 10_1101-2020_03_27_012757 166 9 in in IN 10_1101-2020_03_27_012757 166 10 expression expression NN 10_1101-2020_03_27_012757 166 11 profiles profile NNS 10_1101-2020_03_27_012757 166 12 of of IN 10_1101-2020_03_27_012757 166 13 basal basal NN 10_1101-2020_03_27_012757 166 14 and and CC 10_1101-2020_03_27_012757 166 15 classical classical JJ 10_1101-2020_03_27_012757 166 16 subtypes subtype NNS 10_1101-2020_03_27_012757 166 17 of of IN 10_1101-2020_03_27_012757 166 18 HNSC HNSC NNP 10_1101-2020_03_27_012757 166 19 and and CC 10_1101-2020_03_27_012757 166 20 LUSC28,58 LUSC28,58 NNP 10_1101-2020_03_27_012757 166 21 , , , 10_1101-2020_03_27_012757 166 22 which which WDT 10_1101-2020_03_27_012757 166 23 is be VBZ 10_1101-2020_03_27_012757 166 24 370 370 CD 10_1101-2020_03_27_012757 166 25 .CC .CC , 10_1101-2020_03_27_012757 166 26 - - HYPH 10_1101-2020_03_27_012757 166 27 BY by IN 10_1101-2020_03_27_012757 166 28 - - HYPH 10_1101-2020_03_27_012757 166 29 NC NC NNP 10_1101-2020_03_27_012757 166 30 - - HYPH 10_1101-2020_03_27_012757 166 31 ND ND NNP 10_1101-2020_03_27_012757 166 32 4.0 4.0 CD 10_1101-2020_03_27_012757 166 33 International International NNP 10_1101-2020_03_27_012757 166 34 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 166 35 under under IN 10_1101-2020_03_27_012757 166 36 a a DT 10_1101-2020_03_27_012757 166 37 ( ( -LRB- 10_1101-2020_03_27_012757 166 38 which which WDT 10_1101-2020_03_27_012757 166 39 was be VBD 10_1101-2020_03_27_012757 166 40 not not RB 10_1101-2020_03_27_012757 166 41 certified certify VBN 10_1101-2020_03_27_012757 166 42 by by IN 10_1101-2020_03_27_012757 166 43 peer peer NN 10_1101-2020_03_27_012757 166 44 review review NN 10_1101-2020_03_27_012757 166 45 ) ) -RRB- 10_1101-2020_03_27_012757 166 46 is be VBZ 10_1101-2020_03_27_012757 166 47 the the DT 10_1101-2020_03_27_012757 166 48 author author NN 10_1101-2020_03_27_012757 166 49 / / SYM 10_1101-2020_03_27_012757 166 50 funder funder NN 10_1101-2020_03_27_012757 166 51 , , , 10_1101-2020_03_27_012757 166 52 who who WP 10_1101-2020_03_27_012757 166 53 has have VBZ 10_1101-2020_03_27_012757 166 54 granted grant VBN 10_1101-2020_03_27_012757 166 55 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 166 56 a a DT 10_1101-2020_03_27_012757 166 57 license license NN 10_1101-2020_03_27_012757 166 58 to to TO 10_1101-2020_03_27_012757 166 59 display display VB 10_1101-2020_03_27_012757 166 60 the the DT 10_1101-2020_03_27_012757 166 61 preprint preprint NN 10_1101-2020_03_27_012757 166 62 in in IN 10_1101-2020_03_27_012757 166 63 perpetuity perpetuity NN 10_1101-2020_03_27_012757 166 64 . . . 10_1101-2020_03_27_012757 167 1 It -PRON- PRP 10_1101-2020_03_27_012757 167 2 is be VBZ 10_1101-2020_03_27_012757 167 3 made make VBN 10_1101-2020_03_27_012757 167 4 The the DT 10_1101-2020_03_27_012757 167 5 copyright copyright NN 10_1101-2020_03_27_012757 167 6 holder holder NN 10_1101-2020_03_27_012757 167 7 for for IN 10_1101-2020_03_27_012757 167 8 this this DT 10_1101-2020_03_27_012757 167 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 167 10 version version NN 10_1101-2020_03_27_012757 167 11 posted post VBD 10_1101-2020_03_27_012757 167 12 January January NNP 10_1101-2020_03_27_012757 167 13 9 9 CD 10_1101-2020_03_27_012757 167 14 , , , 10_1101-2020_03_27_012757 167 15 2021 2021 CD 10_1101-2020_03_27_012757 167 16 . . . 10_1101-2020_03_27_012757 167 17 ; ; : 10_1101-2020_03_27_012757 167 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 167 19 : : : 10_1101-2020_03_27_012757 167 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 167 21 preprint preprint NN 10_1101-2020_03_27_012757 167 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 167 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 167 24 14 14 CD 10_1101-2020_03_27_012757 167 25 consistent consistent JJ 10_1101-2020_03_27_012757 167 26 with with IN 10_1101-2020_03_27_012757 167 27 the the DT 10_1101-2020_03_27_012757 167 28 observation observation NN 10_1101-2020_03_27_012757 167 29 that that IN 10_1101-2020_03_27_012757 167 30 these these DT 10_1101-2020_03_27_012757 167 31 PDXs pdx NNS 10_1101-2020_03_27_012757 167 32 were be VBD 10_1101-2020_03_27_012757 167 33 also also RB 10_1101-2020_03_27_012757 167 34 subtyped subtype VBN 10_1101-2020_03_27_012757 167 35 as as IN 10_1101-2020_03_27_012757 167 36 classical classical JJ 10_1101-2020_03_27_012757 167 37 . . . 10_1101-2020_03_27_012757 168 1 No no DT 10_1101-2020_03_27_012757 168 2 LUSC LUSC NNP 10_1101-2020_03_27_012757 168 3 371 371 CD 10_1101-2020_03_27_012757 168 4 PDXs pdx NNS 10_1101-2020_03_27_012757 168 5 were be VBD 10_1101-2020_03_27_012757 168 6 classified classify VBN 10_1101-2020_03_27_012757 168 7 as as IN 10_1101-2020_03_27_012757 168 8 the the DT 10_1101-2020_03_27_012757 168 9 secretory secretory JJ 10_1101-2020_03_27_012757 168 10 subtype subtype NN 10_1101-2020_03_27_012757 168 11 . . . 10_1101-2020_03_27_012757 169 1 In in IN 10_1101-2020_03_27_012757 169 2 contrast contrast NN 10_1101-2020_03_27_012757 169 3 to to IN 10_1101-2020_03_27_012757 169 4 LUAD luad JJ 10_1101-2020_03_27_012757 169 5 CCLs ccl NNS 10_1101-2020_03_27_012757 169 6 , , , 10_1101-2020_03_27_012757 169 7 four four CD 10_1101-2020_03_27_012757 169 8 of of IN 10_1101-2020_03_27_012757 169 9 the the DT 10_1101-2020_03_27_012757 169 10 five five CD 10_1101-2020_03_27_012757 169 11 LUAD luad RB 10_1101-2020_03_27_012757 169 12 372 372 CD 10_1101-2020_03_27_012757 169 13 PDXs pdx NNS 10_1101-2020_03_27_012757 169 14 with with IN 10_1101-2020_03_27_012757 169 15 a a DT 10_1101-2020_03_27_012757 169 16 discernible discernible JJ 10_1101-2020_03_27_012757 169 17 sub sub NN 10_1101-2020_03_27_012757 169 18 - - NN 10_1101-2020_03_27_012757 169 19 type type NN 10_1101-2020_03_27_012757 169 20 were be VBD 10_1101-2020_03_27_012757 169 21 classified classify VBN 10_1101-2020_03_27_012757 169 22 as as IN 10_1101-2020_03_27_012757 169 23 proximal proximal JJ 10_1101-2020_03_27_012757 169 24 inflammatory inflammatory NN 10_1101-2020_03_27_012757 169 25 ( ( -LRB- 10_1101-2020_03_27_012757 169 26 Fig Fig NNP 10_1101-2020_03_27_012757 169 27 5E 5e NN 10_1101-2020_03_27_012757 169 28 ) ) -RRB- 10_1101-2020_03_27_012757 169 29 . . . 10_1101-2020_03_27_012757 170 1 On on IN 10_1101-2020_03_27_012757 170 2 the the DT 10_1101-2020_03_27_012757 170 3 373 373 CD 10_1101-2020_03_27_012757 170 4 other other JJ 10_1101-2020_03_27_012757 170 5 hand hand NN 10_1101-2020_03_27_012757 170 6 , , , 10_1101-2020_03_27_012757 170 7 similar similar JJ 10_1101-2020_03_27_012757 170 8 to to IN 10_1101-2020_03_27_012757 170 9 the the DT 10_1101-2020_03_27_012757 170 10 CCLs ccl NNS 10_1101-2020_03_27_012757 170 11 , , , 10_1101-2020_03_27_012757 170 12 there there EX 10_1101-2020_03_27_012757 170 13 were be VBD 10_1101-2020_03_27_012757 170 14 no no DT 10_1101-2020_03_27_012757 170 15 TRU tru NN 10_1101-2020_03_27_012757 170 16 subtypes subtype NNS 10_1101-2020_03_27_012757 170 17 in in IN 10_1101-2020_03_27_012757 170 18 the the DT 10_1101-2020_03_27_012757 170 19 LUAD LUAD NNP 10_1101-2020_03_27_012757 170 20 PDX pdx NN 10_1101-2020_03_27_012757 170 21 cohort cohort NN 10_1101-2020_03_27_012757 170 22 . . . 10_1101-2020_03_27_012757 171 1 In in IN 10_1101-2020_03_27_012757 171 2 374 374 CD 10_1101-2020_03_27_012757 171 3 summary summary NN 10_1101-2020_03_27_012757 171 4 , , , 10_1101-2020_03_27_012757 171 5 we -PRON- PRP 10_1101-2020_03_27_012757 171 6 found find VBD 10_1101-2020_03_27_012757 171 7 that that IN 10_1101-2020_03_27_012757 171 8 while while IN 10_1101-2020_03_27_012757 171 9 individual individual JJ 10_1101-2020_03_27_012757 171 10 PDXs pdx NNS 10_1101-2020_03_27_012757 171 11 can can MD 10_1101-2020_03_27_012757 171 12 reach reach VB 10_1101-2020_03_27_012757 171 13 extremely extremely RB 10_1101-2020_03_27_012757 171 14 high high JJ 10_1101-2020_03_27_012757 171 15 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 171 16 fidelity fidelity NN 10_1101-2020_03_27_012757 171 17 375 375 CD 10_1101-2020_03_27_012757 171 18 to to IN 10_1101-2020_03_27_012757 171 19 both both CC 10_1101-2020_03_27_012757 171 20 general general JJ 10_1101-2020_03_27_012757 171 21 tumor tumor NN 10_1101-2020_03_27_012757 171 22 types type NNS 10_1101-2020_03_27_012757 171 23 and and CC 10_1101-2020_03_27_012757 171 24 subtypes subtype NNS 10_1101-2020_03_27_012757 171 25 , , , 10_1101-2020_03_27_012757 171 26 many many JJ 10_1101-2020_03_27_012757 171 27 PDXs pdx NNS 10_1101-2020_03_27_012757 171 28 were be VBD 10_1101-2020_03_27_012757 171 29 not not RB 10_1101-2020_03_27_012757 171 30 classified classify VBN 10_1101-2020_03_27_012757 171 31 as as IN 10_1101-2020_03_27_012757 171 32 the the DT 10_1101-2020_03_27_012757 171 33 general general JJ 10_1101-2020_03_27_012757 171 34 tumor tumor NN 10_1101-2020_03_27_012757 171 35 376 376 CD 10_1101-2020_03_27_012757 171 36 type type NN 10_1101-2020_03_27_012757 171 37 from from IN 10_1101-2020_03_27_012757 171 38 which which WDT 10_1101-2020_03_27_012757 171 39 they -PRON- PRP 10_1101-2020_03_27_012757 171 40 originated originate VBD 10_1101-2020_03_27_012757 171 41 . . . 10_1101-2020_03_27_012757 172 1 377 377 CD 10_1101-2020_03_27_012757 172 2 378 378 CD 10_1101-2020_03_27_012757 172 3 Evaluation evaluation NN 10_1101-2020_03_27_012757 172 4 of of IN 10_1101-2020_03_27_012757 172 5 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 172 6 379 379 CD 10_1101-2020_03_27_012757 172 7 Next next RB 10_1101-2020_03_27_012757 172 8 , , , 10_1101-2020_03_27_012757 172 9 we -PRON- PRP 10_1101-2020_03_27_012757 172 10 used use VBD 10_1101-2020_03_27_012757 172 11 CCN CCN NNP 10_1101-2020_03_27_012757 172 12 to to TO 10_1101-2020_03_27_012757 172 13 evaluate evaluate VB 10_1101-2020_03_27_012757 172 14 GEMMs gemm NNS 10_1101-2020_03_27_012757 172 15 of of IN 10_1101-2020_03_27_012757 172 16 six six CD 10_1101-2020_03_27_012757 172 17 general general JJ 10_1101-2020_03_27_012757 172 18 tumor tumor NN 10_1101-2020_03_27_012757 172 19 types type NNS 10_1101-2020_03_27_012757 172 20 from from IN 10_1101-2020_03_27_012757 172 21 nine nine CD 10_1101-2020_03_27_012757 172 22 studies study NNS 10_1101-2020_03_27_012757 172 23 for for IN 10_1101-2020_03_27_012757 172 24 380 380 CD 10_1101-2020_03_27_012757 172 25 which which WDT 10_1101-2020_03_27_012757 172 26 expression expression NN 10_1101-2020_03_27_012757 172 27 data datum NNS 10_1101-2020_03_27_012757 172 28 was be VBD 10_1101-2020_03_27_012757 172 29 publicly publicly RB 10_1101-2020_03_27_012757 172 30 available59–67 available59–67 VBN 10_1101-2020_03_27_012757 172 31 . . . 10_1101-2020_03_27_012757 173 1 As as IN 10_1101-2020_03_27_012757 173 2 was be VBD 10_1101-2020_03_27_012757 173 3 true true JJ 10_1101-2020_03_27_012757 173 4 for for IN 10_1101-2020_03_27_012757 173 5 CCLs ccl NNS 10_1101-2020_03_27_012757 173 6 and and CC 10_1101-2020_03_27_012757 173 7 PDXs pdx NNS 10_1101-2020_03_27_012757 173 8 , , , 10_1101-2020_03_27_012757 173 9 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 173 10 381 381 CD 10_1101-2020_03_27_012757 173 11 also also RB 10_1101-2020_03_27_012757 173 12 had have VBD 10_1101-2020_03_27_012757 173 13 a a DT 10_1101-2020_03_27_012757 173 14 wide wide JJ 10_1101-2020_03_27_012757 173 15 range range NN 10_1101-2020_03_27_012757 173 16 of of IN 10_1101-2020_03_27_012757 173 17 CCN CCN NNP 10_1101-2020_03_27_012757 173 18 scores score NNS 10_1101-2020_03_27_012757 173 19 ( ( -LRB- 10_1101-2020_03_27_012757 173 20 Fig fig NN 10_1101-2020_03_27_012757 173 21 6A 6a NN 10_1101-2020_03_27_012757 173 22 , , , 10_1101-2020_03_27_012757 173 23 Supp Supp NNP 10_1101-2020_03_27_012757 173 24 Tab Tab NNP 10_1101-2020_03_27_012757 173 25 5 5 CD 10_1101-2020_03_27_012757 173 26 ) ) -RRB- 10_1101-2020_03_27_012757 173 27 . . . 10_1101-2020_03_27_012757 174 1 We -PRON- PRP 10_1101-2020_03_27_012757 174 2 next next RB 10_1101-2020_03_27_012757 174 3 categorized categorize VBD 10_1101-2020_03_27_012757 174 4 the the DT 10_1101-2020_03_27_012757 174 5 CCN CCN NNP 10_1101-2020_03_27_012757 174 6 382 382 CD 10_1101-2020_03_27_012757 174 7 scores score NNS 10_1101-2020_03_27_012757 174 8 based base VBN 10_1101-2020_03_27_012757 174 9 on on IN 10_1101-2020_03_27_012757 174 10 the the DT 10_1101-2020_03_27_012757 174 11 proportion proportion NN 10_1101-2020_03_27_012757 174 12 of of IN 10_1101-2020_03_27_012757 174 13 samples sample NNS 10_1101-2020_03_27_012757 174 14 associated associate VBN 10_1101-2020_03_27_012757 174 15 with with IN 10_1101-2020_03_27_012757 174 16 each each DT 10_1101-2020_03_27_012757 174 17 tumor tumor NN 10_1101-2020_03_27_012757 174 18 type type NN 10_1101-2020_03_27_012757 174 19 that that WDT 10_1101-2020_03_27_012757 174 20 were be VBD 10_1101-2020_03_27_012757 174 21 correctly correctly RB 10_1101-2020_03_27_012757 174 22 383 383 CD 10_1101-2020_03_27_012757 174 23 classified classified JJ 10_1101-2020_03_27_012757 174 24 ( ( -LRB- 10_1101-2020_03_27_012757 174 25 Fig Fig NNP 10_1101-2020_03_27_012757 174 26 6B 6b NN 10_1101-2020_03_27_012757 174 27 ) ) -RRB- 10_1101-2020_03_27_012757 174 28 . . . 10_1101-2020_03_27_012757 175 1 In in IN 10_1101-2020_03_27_012757 175 2 contrast contrast NN 10_1101-2020_03_27_012757 175 3 to to IN 10_1101-2020_03_27_012757 175 4 LGG LGG NNP 10_1101-2020_03_27_012757 175 5 CCLs CCLs NNP 10_1101-2020_03_27_012757 175 6 , , , 10_1101-2020_03_27_012757 175 7 LGG LGG NNP 10_1101-2020_03_27_012757 175 8 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 175 9 , , , 10_1101-2020_03_27_012757 175 10 generated generate VBN 10_1101-2020_03_27_012757 175 11 by by IN 10_1101-2020_03_27_012757 175 12 Nf1 Nf1 NNP 10_1101-2020_03_27_012757 175 13 mutations mutation NNS 10_1101-2020_03_27_012757 175 14 384 384 CD 10_1101-2020_03_27_012757 175 15 expressed express VBD 10_1101-2020_03_27_012757 175 16 in in IN 10_1101-2020_03_27_012757 175 17 different different JJ 10_1101-2020_03_27_012757 175 18 neural neural JJ 10_1101-2020_03_27_012757 175 19 progenitors progenitor NNS 10_1101-2020_03_27_012757 175 20 in in IN 10_1101-2020_03_27_012757 175 21 combination combination NN 10_1101-2020_03_27_012757 175 22 with with IN 10_1101-2020_03_27_012757 175 23 Pten Pten NNP 10_1101-2020_03_27_012757 175 24 deletion66 deletion66 NNP 10_1101-2020_03_27_012757 175 25 , , , 10_1101-2020_03_27_012757 175 26 consistently consistently RB 10_1101-2020_03_27_012757 175 27 were be VBD 10_1101-2020_03_27_012757 175 28 385 385 CD 10_1101-2020_03_27_012757 175 29 classified classified JJ 10_1101-2020_03_27_012757 175 30 as as IN 10_1101-2020_03_27_012757 175 31 LGG LGG NNP 10_1101-2020_03_27_012757 175 32 ( ( -LRB- 10_1101-2020_03_27_012757 175 33 Fig fig NN 10_1101-2020_03_27_012757 175 34 6A 6a NN 10_1101-2020_03_27_012757 175 35 - - HYPH 10_1101-2020_03_27_012757 175 36 B b NN 10_1101-2020_03_27_012757 175 37 ) ) -RRB- 10_1101-2020_03_27_012757 175 38 . . . 10_1101-2020_03_27_012757 176 1 The the DT 10_1101-2020_03_27_012757 176 2 GEMM GEMM NNP 10_1101-2020_03_27_012757 176 3 dataset dataset NN 10_1101-2020_03_27_012757 176 4 included include VBD 10_1101-2020_03_27_012757 176 5 multiple multiple JJ 10_1101-2020_03_27_012757 176 6 replicates replicate NNS 10_1101-2020_03_27_012757 176 7 per per IN 10_1101-2020_03_27_012757 176 8 model model NN 10_1101-2020_03_27_012757 176 9 , , , 10_1101-2020_03_27_012757 176 10 which which WDT 10_1101-2020_03_27_012757 176 11 386 386 CD 10_1101-2020_03_27_012757 176 12 allowed allow VBD 10_1101-2020_03_27_012757 176 13 us -PRON- PRP 10_1101-2020_03_27_012757 176 14 to to TO 10_1101-2020_03_27_012757 176 15 examine examine VB 10_1101-2020_03_27_012757 176 16 intra intra JJ 10_1101-2020_03_27_012757 176 17 - - JJ 10_1101-2020_03_27_012757 176 18 GEMM gemm JJ 10_1101-2020_03_27_012757 176 19 variability variability NN 10_1101-2020_03_27_012757 176 20 . . . 10_1101-2020_03_27_012757 177 1 Both both DT 10_1101-2020_03_27_012757 177 2 at at IN 10_1101-2020_03_27_012757 177 3 the the DT 10_1101-2020_03_27_012757 177 4 level level NN 10_1101-2020_03_27_012757 177 5 of of IN 10_1101-2020_03_27_012757 177 6 CCN CCN NNP 10_1101-2020_03_27_012757 177 7 score score NN 10_1101-2020_03_27_012757 177 8 and and CC 10_1101-2020_03_27_012757 177 9 at at IN 10_1101-2020_03_27_012757 177 10 the the DT 10_1101-2020_03_27_012757 177 11 level level NN 10_1101-2020_03_27_012757 177 12 of of IN 10_1101-2020_03_27_012757 177 13 387 387 CD 10_1101-2020_03_27_012757 177 14 categorization categorization NN 10_1101-2020_03_27_012757 177 15 , , , 10_1101-2020_03_27_012757 177 16 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 177 17 were be VBD 10_1101-2020_03_27_012757 177 18 invariant invariant JJ 10_1101-2020_03_27_012757 177 19 . . . 10_1101-2020_03_27_012757 178 1 For for IN 10_1101-2020_03_27_012757 178 2 example example NN 10_1101-2020_03_27_012757 178 3 , , , 10_1101-2020_03_27_012757 178 4 replicates replicate NNS 10_1101-2020_03_27_012757 178 5 of of IN 10_1101-2020_03_27_012757 178 6 UCEC UCEC NNP 10_1101-2020_03_27_012757 178 7 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 178 8 driven drive VBN 10_1101-2020_03_27_012757 178 9 by by IN 10_1101-2020_03_27_012757 178 10 388 388 CD 10_1101-2020_03_27_012757 178 11 Prg(cre/+)Pten(lox Prg(cre/+)Pten(lox NNP 10_1101-2020_03_27_012757 178 12 / / SYM 10_1101-2020_03_27_012757 178 13 lox lox NN 10_1101-2020_03_27_012757 178 14 ) ) -RRB- 10_1101-2020_03_27_012757 178 15 received receive VBD 10_1101-2020_03_27_012757 178 16 almost almost RB 10_1101-2020_03_27_012757 178 17 identical identical JJ 10_1101-2020_03_27_012757 178 18 general general JJ 10_1101-2020_03_27_012757 178 19 CCN CCN NNP 10_1101-2020_03_27_012757 178 20 scores score NNS 10_1101-2020_03_27_012757 178 21 ( ( -LRB- 10_1101-2020_03_27_012757 178 22 Fig fig NN 10_1101-2020_03_27_012757 178 23 6C 6c NN 10_1101-2020_03_27_012757 178 24 , , , 10_1101-2020_03_27_012757 178 25 Supp Supp NNP 10_1101-2020_03_27_012757 178 26 Tab Tab NNP 10_1101-2020_03_27_012757 178 27 6 6 CD 10_1101-2020_03_27_012757 178 28 ) ) -RRB- 10_1101-2020_03_27_012757 178 29 . . . 10_1101-2020_03_27_012757 179 1 389 389 CD 10_1101-2020_03_27_012757 179 2 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 179 3 sharing share VBG 10_1101-2020_03_27_012757 179 4 genotypes genotype NNS 10_1101-2020_03_27_012757 179 5 across across IN 10_1101-2020_03_27_012757 179 6 studies study NNS 10_1101-2020_03_27_012757 179 7 , , , 10_1101-2020_03_27_012757 179 8 such such JJ 10_1101-2020_03_27_012757 179 9 as as IN 10_1101-2020_03_27_012757 179 10 LUAD luad RB 10_1101-2020_03_27_012757 179 11 GEMMs gemm NNS 10_1101-2020_03_27_012757 179 12 driven drive VBN 10_1101-2020_03_27_012757 179 13 by by IN 10_1101-2020_03_27_012757 179 14 Kras Kras NNP 10_1101-2020_03_27_012757 179 15 mutation mutation NN 10_1101-2020_03_27_012757 179 16 and and CC 10_1101-2020_03_27_012757 179 17 390 390 CD 10_1101-2020_03_27_012757 179 18 loss loss NN 10_1101-2020_03_27_012757 179 19 of of IN 10_1101-2020_03_27_012757 179 20 p5359,65,67 p5359,65,67 NNP 10_1101-2020_03_27_012757 179 21 , , , 10_1101-2020_03_27_012757 179 22 also also RB 10_1101-2020_03_27_012757 179 23 received receive VBD 10_1101-2020_03_27_012757 179 24 similar similar JJ 10_1101-2020_03_27_012757 179 25 general general JJ 10_1101-2020_03_27_012757 179 26 and and CC 10_1101-2020_03_27_012757 179 27 subtype subtype NN 10_1101-2020_03_27_012757 179 28 classification classification NN 10_1101-2020_03_27_012757 179 29 scores score NNS 10_1101-2020_03_27_012757 179 30 ( ( -LRB- 10_1101-2020_03_27_012757 179 31 Fig fig NN 10_1101-2020_03_27_012757 179 32 6A 6a NN 10_1101-2020_03_27_012757 179 33 , , , 10_1101-2020_03_27_012757 179 34 B b NN 10_1101-2020_03_27_012757 179 35 , , , 10_1101-2020_03_27_012757 179 36 E e NN 10_1101-2020_03_27_012757 179 37 ) ) -RRB- 10_1101-2020_03_27_012757 179 38 . . . 10_1101-2020_03_27_012757 180 1 391 391 CD 10_1101-2020_03_27_012757 180 2 Next next RB 10_1101-2020_03_27_012757 180 3 , , , 10_1101-2020_03_27_012757 180 4 we -PRON- PRP 10_1101-2020_03_27_012757 180 5 explored explore VBD 10_1101-2020_03_27_012757 180 6 the the DT 10_1101-2020_03_27_012757 180 7 extent extent NN 10_1101-2020_03_27_012757 180 8 to to TO 10_1101-2020_03_27_012757 180 9 which which WDT 10_1101-2020_03_27_012757 180 10 genotype genotype NNP 10_1101-2020_03_27_012757 180 11 impacted impact VBN 10_1101-2020_03_27_012757 180 12 subtype subtype NN 10_1101-2020_03_27_012757 180 13 classification classification NN 10_1101-2020_03_27_012757 180 14 in in IN 10_1101-2020_03_27_012757 180 15 392 392 CD 10_1101-2020_03_27_012757 180 16 UCEC UCEC NNP 10_1101-2020_03_27_012757 180 17 , , , 10_1101-2020_03_27_012757 180 18 LUSC LUSC NNP 10_1101-2020_03_27_012757 180 19 , , , 10_1101-2020_03_27_012757 180 20 and and CC 10_1101-2020_03_27_012757 180 21 LUAD luad RB 10_1101-2020_03_27_012757 180 22 . . . 10_1101-2020_03_27_012757 181 1 Prg(cre/+)Pten(lox Prg(cre/+)Pten(lox NNP 10_1101-2020_03_27_012757 181 2 / / SYM 10_1101-2020_03_27_012757 181 3 lox lox NN 10_1101-2020_03_27_012757 181 4 ) ) -RRB- 10_1101-2020_03_27_012757 181 5 GEMMs gemm NNS 10_1101-2020_03_27_012757 181 6 had have VBD 10_1101-2020_03_27_012757 181 7 a a DT 10_1101-2020_03_27_012757 181 8 mixed mixed JJ 10_1101-2020_03_27_012757 181 9 subtype subtype NN 10_1101-2020_03_27_012757 181 10 classification classification NN 10_1101-2020_03_27_012757 181 11 of of IN 10_1101-2020_03_27_012757 181 12 393 393 CD 10_1101-2020_03_27_012757 181 13 both both CC 10_1101-2020_03_27_012757 181 14 serous serous JJ 10_1101-2020_03_27_012757 181 15 and and CC 10_1101-2020_03_27_012757 181 16 endometrioid endometrioid NN 10_1101-2020_03_27_012757 181 17 , , , 10_1101-2020_03_27_012757 181 18 consistent consistent JJ 10_1101-2020_03_27_012757 181 19 with with IN 10_1101-2020_03_27_012757 181 20 the the DT 10_1101-2020_03_27_012757 181 21 fact fact NN 10_1101-2020_03_27_012757 181 22 that that IN 10_1101-2020_03_27_012757 181 23 Pten Pten NNP 10_1101-2020_03_27_012757 181 24 loss loss NN 10_1101-2020_03_27_012757 181 25 occurs occur VBZ 10_1101-2020_03_27_012757 181 26 in in IN 10_1101-2020_03_27_012757 181 27 both both DT 10_1101-2020_03_27_012757 181 28 subtypes subtype NNS 10_1101-2020_03_27_012757 181 29 394 394 CD 10_1101-2020_03_27_012757 181 30 ( ( -LRB- 10_1101-2020_03_27_012757 181 31 albeit albeit IN 10_1101-2020_03_27_012757 181 32 more more RBR 10_1101-2020_03_27_012757 181 33 frequently frequently RB 10_1101-2020_03_27_012757 181 34 in in IN 10_1101-2020_03_27_012757 181 35 endometrioid endometrioid NN 10_1101-2020_03_27_012757 181 36 ) ) -RRB- 10_1101-2020_03_27_012757 181 37 . . . 10_1101-2020_03_27_012757 182 1 We -PRON- PRP 10_1101-2020_03_27_012757 182 2 also also RB 10_1101-2020_03_27_012757 182 3 analyzed analyze VBD 10_1101-2020_03_27_012757 182 4 Prg(cre/+)Pten(lox Prg(cre/+)Pten(lox NNP 10_1101-2020_03_27_012757 182 5 / / SYM 10_1101-2020_03_27_012757 182 6 lox)Csf3r-/- lox)Csf3r-/- NNS 10_1101-2020_03_27_012757 182 7 395 395 CD 10_1101-2020_03_27_012757 182 8 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 182 9 . . . 10_1101-2020_03_27_012757 183 1 Polymorphonuclear polymorphonuclear NN 10_1101-2020_03_27_012757 183 2 neutrophils neutrophil NNS 10_1101-2020_03_27_012757 183 3 ( ( -LRB- 10_1101-2020_03_27_012757 183 4 PMNs PMNs NNP 10_1101-2020_03_27_012757 183 5 ) ) -RRB- 10_1101-2020_03_27_012757 183 6 , , , 10_1101-2020_03_27_012757 183 7 which which WDT 10_1101-2020_03_27_012757 183 8 play play VBP 10_1101-2020_03_27_012757 183 9 anti anti JJ 10_1101-2020_03_27_012757 183 10 - - JJ 10_1101-2020_03_27_012757 183 11 tumor tumor JJ 10_1101-2020_03_27_012757 183 12 roles role NNS 10_1101-2020_03_27_012757 183 13 in in IN 10_1101-2020_03_27_012757 183 14 endometrioid endometrioid NN 10_1101-2020_03_27_012757 183 15 396 396 CD 10_1101-2020_03_27_012757 183 16 .CC .CC NFP 10_1101-2020_03_27_012757 183 17 - - HYPH 10_1101-2020_03_27_012757 183 18 BY by IN 10_1101-2020_03_27_012757 183 19 - - HYPH 10_1101-2020_03_27_012757 183 20 NC NC NNP 10_1101-2020_03_27_012757 183 21 - - HYPH 10_1101-2020_03_27_012757 183 22 ND ND NNP 10_1101-2020_03_27_012757 183 23 4.0 4.0 CD 10_1101-2020_03_27_012757 183 24 International International NNP 10_1101-2020_03_27_012757 183 25 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 183 26 under under IN 10_1101-2020_03_27_012757 183 27 a a DT 10_1101-2020_03_27_012757 183 28 ( ( -LRB- 10_1101-2020_03_27_012757 183 29 which which WDT 10_1101-2020_03_27_012757 183 30 was be VBD 10_1101-2020_03_27_012757 183 31 not not RB 10_1101-2020_03_27_012757 183 32 certified certify VBN 10_1101-2020_03_27_012757 183 33 by by IN 10_1101-2020_03_27_012757 183 34 peer peer NN 10_1101-2020_03_27_012757 183 35 review review NN 10_1101-2020_03_27_012757 183 36 ) ) -RRB- 10_1101-2020_03_27_012757 183 37 is be VBZ 10_1101-2020_03_27_012757 183 38 the the DT 10_1101-2020_03_27_012757 183 39 author author NN 10_1101-2020_03_27_012757 183 40 / / SYM 10_1101-2020_03_27_012757 183 41 funder funder NN 10_1101-2020_03_27_012757 183 42 , , , 10_1101-2020_03_27_012757 183 43 who who WP 10_1101-2020_03_27_012757 183 44 has have VBZ 10_1101-2020_03_27_012757 183 45 granted grant VBN 10_1101-2020_03_27_012757 183 46 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 183 47 a a DT 10_1101-2020_03_27_012757 183 48 license license NN 10_1101-2020_03_27_012757 183 49 to to TO 10_1101-2020_03_27_012757 183 50 display display VB 10_1101-2020_03_27_012757 183 51 the the DT 10_1101-2020_03_27_012757 183 52 preprint preprint NN 10_1101-2020_03_27_012757 183 53 in in IN 10_1101-2020_03_27_012757 183 54 perpetuity perpetuity NN 10_1101-2020_03_27_012757 183 55 . . . 10_1101-2020_03_27_012757 184 1 It -PRON- PRP 10_1101-2020_03_27_012757 184 2 is be VBZ 10_1101-2020_03_27_012757 184 3 made make VBN 10_1101-2020_03_27_012757 184 4 The the DT 10_1101-2020_03_27_012757 184 5 copyright copyright NN 10_1101-2020_03_27_012757 184 6 holder holder NN 10_1101-2020_03_27_012757 184 7 for for IN 10_1101-2020_03_27_012757 184 8 this this DT 10_1101-2020_03_27_012757 184 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 184 10 version version NN 10_1101-2020_03_27_012757 184 11 posted post VBD 10_1101-2020_03_27_012757 184 12 January January NNP 10_1101-2020_03_27_012757 184 13 9 9 CD 10_1101-2020_03_27_012757 184 14 , , , 10_1101-2020_03_27_012757 184 15 2021 2021 CD 10_1101-2020_03_27_012757 184 16 . . . 10_1101-2020_03_27_012757 184 17 ; ; : 10_1101-2020_03_27_012757 184 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 184 19 : : : 10_1101-2020_03_27_012757 184 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 184 21 preprint preprint NN 10_1101-2020_03_27_012757 184 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 184 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 184 24 15 15 CD 10_1101-2020_03_27_012757 184 25 cancer cancer NN 10_1101-2020_03_27_012757 184 26 progression progression NN 10_1101-2020_03_27_012757 184 27 , , , 10_1101-2020_03_27_012757 184 28 are be VBP 10_1101-2020_03_27_012757 184 29 depleted deplete VBN 10_1101-2020_03_27_012757 184 30 in in IN 10_1101-2020_03_27_012757 184 31 these these DT 10_1101-2020_03_27_012757 184 32 animals animal NNS 10_1101-2020_03_27_012757 184 33 . . . 10_1101-2020_03_27_012757 185 1 Interestingly interestingly RB 10_1101-2020_03_27_012757 185 2 , , , 10_1101-2020_03_27_012757 185 3 Prg(cre/+)Pten(lox Prg(cre/+)Pten(lox NNP 10_1101-2020_03_27_012757 185 4 / / SYM 10_1101-2020_03_27_012757 185 5 lox)Csf3r-/- lox)Csf3r-/- NNS 10_1101-2020_03_27_012757 185 6 397 397 CD 10_1101-2020_03_27_012757 185 7 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 185 8 had have VBD 10_1101-2020_03_27_012757 185 9 a a DT 10_1101-2020_03_27_012757 185 10 serous serous JJ 10_1101-2020_03_27_012757 185 11 subtype subtype NN 10_1101-2020_03_27_012757 185 12 classification classification NN 10_1101-2020_03_27_012757 185 13 , , , 10_1101-2020_03_27_012757 185 14 which which WDT 10_1101-2020_03_27_012757 185 15 could could MD 10_1101-2020_03_27_012757 185 16 be be VB 10_1101-2020_03_27_012757 185 17 explained explain VBN 10_1101-2020_03_27_012757 185 18 by by IN 10_1101-2020_03_27_012757 185 19 differences difference NNS 10_1101-2020_03_27_012757 185 20 in in IN 10_1101-2020_03_27_012757 185 21 PMN pmn NN 10_1101-2020_03_27_012757 185 22 398 398 CD 10_1101-2020_03_27_012757 185 23 involvement involvement NN 10_1101-2020_03_27_012757 185 24 in in IN 10_1101-2020_03_27_012757 185 25 endometrioid endometrioid NN 10_1101-2020_03_27_012757 185 26 versus versus IN 10_1101-2020_03_27_012757 185 27 serous serous JJ 10_1101-2020_03_27_012757 185 28 uterine uterine JJ 10_1101-2020_03_27_012757 185 29 tumor tumor NN 10_1101-2020_03_27_012757 185 30 development development NN 10_1101-2020_03_27_012757 185 31 that that WDT 10_1101-2020_03_27_012757 185 32 are be VBP 10_1101-2020_03_27_012757 185 33 reflected reflect VBN 10_1101-2020_03_27_012757 185 34 in in IN 10_1101-2020_03_27_012757 185 35 the the DT 10_1101-2020_03_27_012757 185 36 399 399 CD 10_1101-2020_03_27_012757 185 37 respective respective JJ 10_1101-2020_03_27_012757 185 38 transcriptomes transcriptome NNS 10_1101-2020_03_27_012757 185 39 of of IN 10_1101-2020_03_27_012757 185 40 the the DT 10_1101-2020_03_27_012757 185 41 TCGA TCGA NNP 10_1101-2020_03_27_012757 185 42 UCEC UCEC NNP 10_1101-2020_03_27_012757 185 43 training training NN 10_1101-2020_03_27_012757 185 44 data datum NNS 10_1101-2020_03_27_012757 185 45 . . . 10_1101-2020_03_27_012757 186 1 We -PRON- PRP 10_1101-2020_03_27_012757 186 2 note note VBP 10_1101-2020_03_27_012757 186 3 that that IN 10_1101-2020_03_27_012757 186 4 the the DT 10_1101-2020_03_27_012757 186 5 tumor tumor NN 10_1101-2020_03_27_012757 186 6 cells cell NNS 10_1101-2020_03_27_012757 186 7 were be VBD 10_1101-2020_03_27_012757 186 8 400 400 CD 10_1101-2020_03_27_012757 186 9 sorted sort VBN 10_1101-2020_03_27_012757 186 10 prior prior RB 10_1101-2020_03_27_012757 186 11 to to IN 10_1101-2020_03_27_012757 186 12 RNA RNA NNP 10_1101-2020_03_27_012757 186 13 - - HYPH 10_1101-2020_03_27_012757 186 14 seq seq NN 10_1101-2020_03_27_012757 186 15 and and CC 10_1101-2020_03_27_012757 186 16 thus thus RB 10_1101-2020_03_27_012757 186 17 the the DT 10_1101-2020_03_27_012757 186 18 shift shift NN 10_1101-2020_03_27_012757 186 19 in in IN 10_1101-2020_03_27_012757 186 20 subtype subtype NN 10_1101-2020_03_27_012757 186 21 classification classification NN 10_1101-2020_03_27_012757 186 22 is be VBZ 10_1101-2020_03_27_012757 186 23 not not RB 10_1101-2020_03_27_012757 186 24 due due JJ 10_1101-2020_03_27_012757 186 25 to to IN 10_1101-2020_03_27_012757 186 26 contamination contamination NN 10_1101-2020_03_27_012757 186 27 of of IN 10_1101-2020_03_27_012757 186 28 401 401 CD 10_1101-2020_03_27_012757 186 29 GEMMs gemm NNS 10_1101-2020_03_27_012757 186 30 with with IN 10_1101-2020_03_27_012757 186 31 non non JJ 10_1101-2020_03_27_012757 186 32 - - JJ 10_1101-2020_03_27_012757 186 33 tumor tumor JJ 10_1101-2020_03_27_012757 186 34 components component NNS 10_1101-2020_03_27_012757 186 35 . . . 10_1101-2020_03_27_012757 187 1 In in IN 10_1101-2020_03_27_012757 187 2 short short JJ 10_1101-2020_03_27_012757 187 3 , , , 10_1101-2020_03_27_012757 187 4 this this DT 10_1101-2020_03_27_012757 187 5 analysis analysis NN 10_1101-2020_03_27_012757 187 6 supports support VBZ 10_1101-2020_03_27_012757 187 7 the the DT 10_1101-2020_03_27_012757 187 8 argument argument NN 10_1101-2020_03_27_012757 187 9 that that WDT 10_1101-2020_03_27_012757 187 10 tumor-402 tumor-402 JJ 10_1101-2020_03_27_012757 187 11 cell cell NN 10_1101-2020_03_27_012757 187 12 extrinsic extrinsic NN 10_1101-2020_03_27_012757 187 13 factors factor NNS 10_1101-2020_03_27_012757 187 14 , , , 10_1101-2020_03_27_012757 187 15 in in IN 10_1101-2020_03_27_012757 187 16 this this DT 10_1101-2020_03_27_012757 187 17 case case NN 10_1101-2020_03_27_012757 187 18 a a DT 10_1101-2020_03_27_012757 187 19 reduction reduction NN 10_1101-2020_03_27_012757 187 20 in in IN 10_1101-2020_03_27_012757 187 21 anti anti JJ 10_1101-2020_03_27_012757 187 22 - - JJ 10_1101-2020_03_27_012757 187 23 tumor tumor JJ 10_1101-2020_03_27_012757 187 24 PMNs pmn NNS 10_1101-2020_03_27_012757 187 25 , , , 10_1101-2020_03_27_012757 187 26 can can MD 10_1101-2020_03_27_012757 187 27 shift shift VB 10_1101-2020_03_27_012757 187 28 the the DT 10_1101-2020_03_27_012757 187 29 transcriptome transcriptome CD 10_1101-2020_03_27_012757 187 30 of of IN 10_1101-2020_03_27_012757 187 31 403 403 CD 10_1101-2020_03_27_012757 187 32 a a DT 10_1101-2020_03_27_012757 187 33 GEMM GEMM NNP 10_1101-2020_03_27_012757 187 34 so so IN 10_1101-2020_03_27_012757 187 35 that that IN 10_1101-2020_03_27_012757 187 36 it -PRON- PRP 10_1101-2020_03_27_012757 187 37 more more RBR 10_1101-2020_03_27_012757 187 38 closely closely RB 10_1101-2020_03_27_012757 187 39 resembles resemble VBZ 10_1101-2020_03_27_012757 187 40 a a DT 10_1101-2020_03_27_012757 187 41 serous serous JJ 10_1101-2020_03_27_012757 187 42 rather rather RB 10_1101-2020_03_27_012757 187 43 than than IN 10_1101-2020_03_27_012757 187 44 endometrioid endometrioid NN 10_1101-2020_03_27_012757 187 45 subtype subtype NN 10_1101-2020_03_27_012757 187 46 . . . 10_1101-2020_03_27_012757 188 1 404 404 CD 10_1101-2020_03_27_012757 188 2 The the DT 10_1101-2020_03_27_012757 188 3 LUSC LUSC NNP 10_1101-2020_03_27_012757 188 4 GEMMs gemm VBZ 10_1101-2020_03_27_012757 188 5 that that IN 10_1101-2020_03_27_012757 188 6 we -PRON- PRP 10_1101-2020_03_27_012757 188 7 analyzed analyze VBD 10_1101-2020_03_27_012757 188 8 were be VBD 10_1101-2020_03_27_012757 188 9 Lkb1fl Lkb1fl NNP 10_1101-2020_03_27_012757 188 10 / / SYM 10_1101-2020_03_27_012757 188 11 fl fl NN 10_1101-2020_03_27_012757 188 12 and and CC 10_1101-2020_03_27_012757 188 13 they -PRON- PRP 10_1101-2020_03_27_012757 188 14 either either CC 10_1101-2020_03_27_012757 188 15 overexpressed overexpresse VBN 10_1101-2020_03_27_012757 188 16 of of IN 10_1101-2020_03_27_012757 188 17 405 405 CD 10_1101-2020_03_27_012757 188 18 Sox2 Sox2 NNPS 10_1101-2020_03_27_012757 188 19 ( ( -LRB- 10_1101-2020_03_27_012757 188 20 via via IN 10_1101-2020_03_27_012757 188 21 two two CD 10_1101-2020_03_27_012757 188 22 distinct distinct JJ 10_1101-2020_03_27_012757 188 23 mechanisms mechanism NNS 10_1101-2020_03_27_012757 188 24 ) ) -RRB- 10_1101-2020_03_27_012757 188 25 or or CC 10_1101-2020_03_27_012757 188 26 were be VBD 10_1101-2020_03_27_012757 188 27 also also RB 10_1101-2020_03_27_012757 188 28 Ptenfl Ptenfl NNP 10_1101-2020_03_27_012757 188 29 / / SYM 10_1101-2020_03_27_012757 188 30 fl fl NNP 10_1101-2020_03_27_012757 188 31 65 65 CD 10_1101-2020_03_27_012757 188 32 . . . 10_1101-2020_03_27_012757 189 1 We -PRON- PRP 10_1101-2020_03_27_012757 189 2 note note VBP 10_1101-2020_03_27_012757 189 3 that that IN 10_1101-2020_03_27_012757 189 4 the the DT 10_1101-2020_03_27_012757 189 5 eight eight CD 10_1101-2020_03_27_012757 189 6 lenti lenti NN 10_1101-2020_03_27_012757 189 7 - - HYPH 10_1101-2020_03_27_012757 189 8 Sox2 sox2 NN 10_1101-2020_03_27_012757 189 9 - - HYPH 10_1101-2020_03_27_012757 189 10 406 406 CD 10_1101-2020_03_27_012757 189 11 Cre Cre NNP 10_1101-2020_03_27_012757 189 12 - - HYPH 10_1101-2020_03_27_012757 189 13 infected;Lkb1fl infected;Lkb1fl NNP 10_1101-2020_03_27_012757 189 14 / / SYM 10_1101-2020_03_27_012757 189 15 fl fl NN 10_1101-2020_03_27_012757 189 16 and and CC 10_1101-2020_03_27_012757 189 17 Rosa26LSL Rosa26LSL NNP 10_1101-2020_03_27_012757 189 18 - - HYPH 10_1101-2020_03_27_012757 189 19 Sox2-IRES Sox2-IRES NNP 10_1101-2020_03_27_012757 189 20 - - HYPH 10_1101-2020_03_27_012757 189 21 GFP;Lkb1fl GFP;Lkb1fl NNP 10_1101-2020_03_27_012757 189 22 / / SYM 10_1101-2020_03_27_012757 189 23 fl fl NN 10_1101-2020_03_27_012757 189 24 samples sample NNS 10_1101-2020_03_27_012757 189 25 that that WDT 10_1101-2020_03_27_012757 189 26 classified classify VBD 10_1101-2020_03_27_012757 189 27 as as IN 10_1101-2020_03_27_012757 189 28 407 407 CD 10_1101-2020_03_27_012757 189 29 ' ' `` 10_1101-2020_03_27_012757 189 30 Unknown unknown JJ 10_1101-2020_03_27_012757 189 31 ' ' '' 10_1101-2020_03_27_012757 189 32 had have VBD 10_1101-2020_03_27_012757 189 33 LUSC LUSC NNP 10_1101-2020_03_27_012757 189 34 CCN CCN NNP 10_1101-2020_03_27_012757 189 35 scores score NNS 10_1101-2020_03_27_012757 189 36 only only RB 10_1101-2020_03_27_012757 189 37 modestly modestly RB 10_1101-2020_03_27_012757 189 38 lower low JJR 10_1101-2020_03_27_012757 189 39 than than IN 10_1101-2020_03_27_012757 189 40 the the DT 10_1101-2020_03_27_012757 189 41 decision decision NN 10_1101-2020_03_27_012757 189 42 threshold threshold NN 10_1101-2020_03_27_012757 189 43 ( ( -LRB- 10_1101-2020_03_27_012757 189 44 Fig Fig NNP 10_1101-2020_03_27_012757 189 45 6D 6d NN 10_1101-2020_03_27_012757 189 46 ) ) -RRB- 10_1101-2020_03_27_012757 189 47 408 408 CD 10_1101-2020_03_27_012757 189 48 ( ( -LRB- 10_1101-2020_03_27_012757 189 49 mean mean VB 10_1101-2020_03_27_012757 189 50 CCN CCN NNP 10_1101-2020_03_27_012757 189 51 score score VBP 10_1101-2020_03_27_012757 189 52 = = SYM 10_1101-2020_03_27_012757 189 53 0.217 0.217 CD 10_1101-2020_03_27_012757 189 54 ) ) -RRB- 10_1101-2020_03_27_012757 189 55 . . . 10_1101-2020_03_27_012757 190 1 Thirteen thirteen CD 10_1101-2020_03_27_012757 190 2 out out IN 10_1101-2020_03_27_012757 190 3 of of IN 10_1101-2020_03_27_012757 190 4 the the DT 10_1101-2020_03_27_012757 190 5 17 17 CD 10_1101-2020_03_27_012757 190 6 of of IN 10_1101-2020_03_27_012757 190 7 the the DT 10_1101-2020_03_27_012757 190 8 Sox2 Sox2 NNPS 10_1101-2020_03_27_012757 190 9 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 190 10 classified classify VBD 10_1101-2020_03_27_012757 190 11 as as IN 10_1101-2020_03_27_012757 190 12 the the DT 10_1101-2020_03_27_012757 190 13 409 409 CD 10_1101-2020_03_27_012757 190 14 secretory secretory JJ 10_1101-2020_03_27_012757 190 15 subtype subtype NN 10_1101-2020_03_27_012757 190 16 of of IN 10_1101-2020_03_27_012757 190 17 LUSC LUSC NNP 10_1101-2020_03_27_012757 190 18 . . . 10_1101-2020_03_27_012757 191 1 The the DT 10_1101-2020_03_27_012757 191 2 consistency consistency NN 10_1101-2020_03_27_012757 191 3 is be VBZ 10_1101-2020_03_27_012757 191 4 not not RB 10_1101-2020_03_27_012757 191 5 surprising surprising JJ 10_1101-2020_03_27_012757 191 6 given give VBN 10_1101-2020_03_27_012757 191 7 both both DT 10_1101-2020_03_27_012757 191 8 models model NNS 10_1101-2020_03_27_012757 191 9 overexpress overexpres VBD 10_1101-2020_03_27_012757 191 10 410 410 CD 10_1101-2020_03_27_012757 191 11 Sox2 Sox2 NNPS 10_1101-2020_03_27_012757 191 12 and and CC 10_1101-2020_03_27_012757 191 13 lose lose VB 10_1101-2020_03_27_012757 191 14 Lkb1 Lkb1 NNP 10_1101-2020_03_27_012757 191 15 . . . 10_1101-2020_03_27_012757 192 1 On on IN 10_1101-2020_03_27_012757 192 2 the the DT 10_1101-2020_03_27_012757 192 3 other other JJ 10_1101-2020_03_27_012757 192 4 hand hand NN 10_1101-2020_03_27_012757 192 5 , , , 10_1101-2020_03_27_012757 192 6 the the DT 10_1101-2020_03_27_012757 192 7 Lkb1fl Lkb1fl NNP 10_1101-2020_03_27_012757 192 8 / / SYM 10_1101-2020_03_27_012757 192 9 fl;Ptenfl fl;Ptenfl NNP 10_1101-2020_03_27_012757 192 10 / / SYM 10_1101-2020_03_27_012757 192 11 fl fl NN 10_1101-2020_03_27_012757 192 12 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 192 13 had have VBD 10_1101-2020_03_27_012757 192 14 substantially substantially RB 10_1101-2020_03_27_012757 192 15 lower low JJR 10_1101-2020_03_27_012757 192 16 411 411 CD 10_1101-2020_03_27_012757 192 17 general general JJ 10_1101-2020_03_27_012757 192 18 LUSC LUSC NNP 10_1101-2020_03_27_012757 192 19 CCN CCN NNP 10_1101-2020_03_27_012757 192 20 scores score NNS 10_1101-2020_03_27_012757 192 21 and and CC 10_1101-2020_03_27_012757 192 22 our -PRON- PRP$ 10_1101-2020_03_27_012757 192 23 subtype subtype NN 10_1101-2020_03_27_012757 192 24 classification classification NN 10_1101-2020_03_27_012757 192 25 indicated indicate VBD 10_1101-2020_03_27_012757 192 26 that that IN 10_1101-2020_03_27_012757 192 27 this this DT 10_1101-2020_03_27_012757 192 28 GEMM GEMM NNP 10_1101-2020_03_27_012757 192 29 was be VBD 10_1101-2020_03_27_012757 192 30 mostly mostly RB 10_1101-2020_03_27_012757 192 31 412 412 CD 10_1101-2020_03_27_012757 192 32 classified classify VBD 10_1101-2020_03_27_012757 192 33 as as IN 10_1101-2020_03_27_012757 192 34 ' ' `` 10_1101-2020_03_27_012757 192 35 Unknown unknown JJ 10_1101-2020_03_27_012757 192 36 ' ' '' 10_1101-2020_03_27_012757 192 37 , , , 10_1101-2020_03_27_012757 192 38 in in IN 10_1101-2020_03_27_012757 192 39 contrast contrast NN 10_1101-2020_03_27_012757 192 40 to to IN 10_1101-2020_03_27_012757 192 41 prior prior JJ 10_1101-2020_03_27_012757 192 42 reports report NNS 10_1101-2020_03_27_012757 192 43 suggesting suggest VBG 10_1101-2020_03_27_012757 192 44 that that IN 10_1101-2020_03_27_012757 192 45 it -PRON- PRP 10_1101-2020_03_27_012757 192 46 is be VBZ 10_1101-2020_03_27_012757 192 47 most most RBS 10_1101-2020_03_27_012757 192 48 similar similar JJ 10_1101-2020_03_27_012757 192 49 to to IN 10_1101-2020_03_27_012757 192 50 a a DT 10_1101-2020_03_27_012757 192 51 basal basal NN 10_1101-2020_03_27_012757 192 52 413 413 CD 10_1101-2020_03_27_012757 192 53 subtype68 subtype68 NN 10_1101-2020_03_27_012757 192 54 . . . 10_1101-2020_03_27_012757 193 1 None none NN 10_1101-2020_03_27_012757 193 2 of of IN 10_1101-2020_03_27_012757 193 3 the the DT 10_1101-2020_03_27_012757 193 4 three three CD 10_1101-2020_03_27_012757 193 5 LUSC LUSC NNP 10_1101-2020_03_27_012757 193 6 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 193 7 have have VBP 10_1101-2020_03_27_012757 193 8 strong strong JJ 10_1101-2020_03_27_012757 193 9 classical classical JJ 10_1101-2020_03_27_012757 193 10 CCN CCN NNP 10_1101-2020_03_27_012757 193 11 scores score NNS 10_1101-2020_03_27_012757 193 12 . . . 10_1101-2020_03_27_012757 194 1 Most Most JJS 10_1101-2020_03_27_012757 194 2 of of IN 10_1101-2020_03_27_012757 194 3 the the DT 10_1101-2020_03_27_012757 194 4 414 414 CD 10_1101-2020_03_27_012757 194 5 LUAD luad RB 10_1101-2020_03_27_012757 194 6 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 194 7 , , , 10_1101-2020_03_27_012757 194 8 which which WDT 10_1101-2020_03_27_012757 194 9 were be VBD 10_1101-2020_03_27_012757 194 10 generated generate VBN 10_1101-2020_03_27_012757 194 11 using use VBG 10_1101-2020_03_27_012757 194 12 various various JJ 10_1101-2020_03_27_012757 194 13 combinations combination NNS 10_1101-2020_03_27_012757 194 14 of of IN 10_1101-2020_03_27_012757 194 15 activating activate VBG 10_1101-2020_03_27_012757 194 16 Kras Kras NNP 10_1101-2020_03_27_012757 194 17 mutation mutation NN 10_1101-2020_03_27_012757 194 18 , , , 10_1101-2020_03_27_012757 194 19 415 415 CD 10_1101-2020_03_27_012757 194 20 loss loss NN 10_1101-2020_03_27_012757 194 21 of of IN 10_1101-2020_03_27_012757 194 22 Trp53 Trp53 NNP 10_1101-2020_03_27_012757 194 23 , , , 10_1101-2020_03_27_012757 194 24 and and CC 10_1101-2020_03_27_012757 194 25 loss loss NN 10_1101-2020_03_27_012757 194 26 of of IN 10_1101-2020_03_27_012757 194 27 Smarca4L59,65,67 Smarca4L59,65,67 NNP 10_1101-2020_03_27_012757 194 28 , , , 10_1101-2020_03_27_012757 194 29 were be VBD 10_1101-2020_03_27_012757 194 30 correctly correctly RB 10_1101-2020_03_27_012757 194 31 classified classified JJ 10_1101-2020_03_27_012757 194 32 ( ( -LRB- 10_1101-2020_03_27_012757 194 33 Fig Fig NNP 10_1101-2020_03_27_012757 194 34 6E 6e NN 10_1101-2020_03_27_012757 194 35 ) ) -RRB- 10_1101-2020_03_27_012757 194 36 . . . 10_1101-2020_03_27_012757 195 1 Those those DT 10_1101-2020_03_27_012757 195 2 that that WDT 10_1101-2020_03_27_012757 195 3 were be VBD 10_1101-2020_03_27_012757 195 4 416 416 CD 10_1101-2020_03_27_012757 195 5 not not RB 10_1101-2020_03_27_012757 195 6 classified classify VBN 10_1101-2020_03_27_012757 195 7 have have VBP 10_1101-2020_03_27_012757 195 8 modestly modestly RB 10_1101-2020_03_27_012757 195 9 lower low JJR 10_1101-2020_03_27_012757 195 10 CCN CCN NNP 10_1101-2020_03_27_012757 195 11 score score NN 10_1101-2020_03_27_012757 195 12 than than IN 10_1101-2020_03_27_012757 195 13 the the DT 10_1101-2020_03_27_012757 195 14 decision decision NN 10_1101-2020_03_27_012757 195 15 threshold threshold NN 10_1101-2020_03_27_012757 195 16 ( ( -LRB- 10_1101-2020_03_27_012757 195 17 mean mean VB 10_1101-2020_03_27_012757 195 18 CCN CCN NNP 10_1101-2020_03_27_012757 195 19 score score NN 10_1101-2020_03_27_012757 195 20 = = SYM 10_1101-2020_03_27_012757 195 21 417 417 CD 10_1101-2020_03_27_012757 195 22 0.214 0.214 CD 10_1101-2020_03_27_012757 195 23 ) ) -RRB- 10_1101-2020_03_27_012757 195 24 . . . 10_1101-2020_03_27_012757 196 1 There there EX 10_1101-2020_03_27_012757 196 2 were be VBD 10_1101-2020_03_27_012757 196 3 no no DT 10_1101-2020_03_27_012757 196 4 substantial substantial JJ 10_1101-2020_03_27_012757 196 5 differences difference NNS 10_1101-2020_03_27_012757 196 6 in in IN 10_1101-2020_03_27_012757 196 7 general general JJ 10_1101-2020_03_27_012757 196 8 or or CC 10_1101-2020_03_27_012757 196 9 subtype subtype NN 10_1101-2020_03_27_012757 196 10 classification classification NN 10_1101-2020_03_27_012757 196 11 across across IN 10_1101-2020_03_27_012757 196 12 driver driver NN 10_1101-2020_03_27_012757 196 13 418 418 CD 10_1101-2020_03_27_012757 196 14 genotypes genotype NNS 10_1101-2020_03_27_012757 196 15 . . . 10_1101-2020_03_27_012757 197 1 Although although IN 10_1101-2020_03_27_012757 197 2 the the DT 10_1101-2020_03_27_012757 197 3 sub sub NN 10_1101-2020_03_27_012757 197 4 - - HYPH 10_1101-2020_03_27_012757 197 5 type type NN 10_1101-2020_03_27_012757 197 6 of of IN 10_1101-2020_03_27_012757 197 7 all all DT 10_1101-2020_03_27_012757 197 8 LUAD luad RB 10_1101-2020_03_27_012757 197 9 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 197 10 was be VBD 10_1101-2020_03_27_012757 197 11 ' ' `` 10_1101-2020_03_27_012757 197 12 Unknown unknown JJ 10_1101-2020_03_27_012757 197 13 ' ' '' 10_1101-2020_03_27_012757 197 14 , , , 10_1101-2020_03_27_012757 197 15 the the DT 10_1101-2020_03_27_012757 197 16 subtypes subtype NNS 10_1101-2020_03_27_012757 197 17 tended tend VBD 10_1101-2020_03_27_012757 197 18 to to IN 10_1101-2020_03_27_012757 197 19 419 419 CD 10_1101-2020_03_27_012757 197 20 have have VB 10_1101-2020_03_27_012757 197 21 a a DT 10_1101-2020_03_27_012757 197 22 mixture mixture NN 10_1101-2020_03_27_012757 197 23 of of IN 10_1101-2020_03_27_012757 197 24 high high JJ 10_1101-2020_03_27_012757 197 25 CCN CCN NNP 10_1101-2020_03_27_012757 197 26 proximal proximal JJ 10_1101-2020_03_27_012757 197 27 proliferation proliferation NN 10_1101-2020_03_27_012757 197 28 , , , 10_1101-2020_03_27_012757 197 29 proximal proximal JJ 10_1101-2020_03_27_012757 197 30 inflammation inflammation NN 10_1101-2020_03_27_012757 197 31 and and CC 10_1101-2020_03_27_012757 197 32 TRU tru NN 10_1101-2020_03_27_012757 197 33 scores score NNS 10_1101-2020_03_27_012757 197 34 . . . 10_1101-2020_03_27_012757 198 1 420 420 CD 10_1101-2020_03_27_012757 198 2 Taken take VBN 10_1101-2020_03_27_012757 198 3 together together RB 10_1101-2020_03_27_012757 198 4 , , , 10_1101-2020_03_27_012757 198 5 this this DT 10_1101-2020_03_27_012757 198 6 analysis analysis NN 10_1101-2020_03_27_012757 198 7 suggests suggest VBZ 10_1101-2020_03_27_012757 198 8 that that IN 10_1101-2020_03_27_012757 198 9 there there EX 10_1101-2020_03_27_012757 198 10 is be VBZ 10_1101-2020_03_27_012757 198 11 a a DT 10_1101-2020_03_27_012757 198 12 degree degree NN 10_1101-2020_03_27_012757 198 13 of of IN 10_1101-2020_03_27_012757 198 14 similarity similarity NN 10_1101-2020_03_27_012757 198 15 , , , 10_1101-2020_03_27_012757 198 16 and and CC 10_1101-2020_03_27_012757 198 17 perhaps perhaps RB 10_1101-2020_03_27_012757 198 18 plasticity plasticity NN 10_1101-2020_03_27_012757 198 19 421 421 CD 10_1101-2020_03_27_012757 198 20 between between IN 10_1101-2020_03_27_012757 198 21 the the DT 10_1101-2020_03_27_012757 198 22 primitive primitive JJ 10_1101-2020_03_27_012757 198 23 and and CC 10_1101-2020_03_27_012757 198 24 secretory secretory JJ 10_1101-2020_03_27_012757 198 25 ( ( -LRB- 10_1101-2020_03_27_012757 198 26 but but CC 10_1101-2020_03_27_012757 198 27 not not RB 10_1101-2020_03_27_012757 198 28 basal basal JJ 10_1101-2020_03_27_012757 198 29 or or CC 10_1101-2020_03_27_012757 198 30 classical classical JJ 10_1101-2020_03_27_012757 198 31 ) ) -RRB- 10_1101-2020_03_27_012757 198 32 subtypes subtype NNS 10_1101-2020_03_27_012757 198 33 of of IN 10_1101-2020_03_27_012757 198 34 LUSC LUSC NNP 10_1101-2020_03_27_012757 198 35 . . . 10_1101-2020_03_27_012757 199 1 On on IN 10_1101-2020_03_27_012757 199 2 the the DT 10_1101-2020_03_27_012757 199 3 other other JJ 10_1101-2020_03_27_012757 199 4 422 422 CD 10_1101-2020_03_27_012757 199 5 .CC .CC : 10_1101-2020_03_27_012757 199 6 - - HYPH 10_1101-2020_03_27_012757 199 7 BY by IN 10_1101-2020_03_27_012757 199 8 - - HYPH 10_1101-2020_03_27_012757 199 9 NC NC NNP 10_1101-2020_03_27_012757 199 10 - - HYPH 10_1101-2020_03_27_012757 199 11 ND ND NNP 10_1101-2020_03_27_012757 199 12 4.0 4.0 CD 10_1101-2020_03_27_012757 199 13 International International NNP 10_1101-2020_03_27_012757 199 14 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 199 15 under under IN 10_1101-2020_03_27_012757 199 16 a a DT 10_1101-2020_03_27_012757 199 17 ( ( -LRB- 10_1101-2020_03_27_012757 199 18 which which WDT 10_1101-2020_03_27_012757 199 19 was be VBD 10_1101-2020_03_27_012757 199 20 not not RB 10_1101-2020_03_27_012757 199 21 certified certify VBN 10_1101-2020_03_27_012757 199 22 by by IN 10_1101-2020_03_27_012757 199 23 peer peer NN 10_1101-2020_03_27_012757 199 24 review review NN 10_1101-2020_03_27_012757 199 25 ) ) -RRB- 10_1101-2020_03_27_012757 199 26 is be VBZ 10_1101-2020_03_27_012757 199 27 the the DT 10_1101-2020_03_27_012757 199 28 author author NN 10_1101-2020_03_27_012757 199 29 / / SYM 10_1101-2020_03_27_012757 199 30 funder funder NN 10_1101-2020_03_27_012757 199 31 , , , 10_1101-2020_03_27_012757 199 32 who who WP 10_1101-2020_03_27_012757 199 33 has have VBZ 10_1101-2020_03_27_012757 199 34 granted grant VBN 10_1101-2020_03_27_012757 199 35 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 199 36 a a DT 10_1101-2020_03_27_012757 199 37 license license NN 10_1101-2020_03_27_012757 199 38 to to TO 10_1101-2020_03_27_012757 199 39 display display VB 10_1101-2020_03_27_012757 199 40 the the DT 10_1101-2020_03_27_012757 199 41 preprint preprint NN 10_1101-2020_03_27_012757 199 42 in in IN 10_1101-2020_03_27_012757 199 43 perpetuity perpetuity NN 10_1101-2020_03_27_012757 199 44 . . . 10_1101-2020_03_27_012757 200 1 It -PRON- PRP 10_1101-2020_03_27_012757 200 2 is be VBZ 10_1101-2020_03_27_012757 200 3 made make VBN 10_1101-2020_03_27_012757 200 4 The the DT 10_1101-2020_03_27_012757 200 5 copyright copyright NN 10_1101-2020_03_27_012757 200 6 holder holder NN 10_1101-2020_03_27_012757 200 7 for for IN 10_1101-2020_03_27_012757 200 8 this this DT 10_1101-2020_03_27_012757 200 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 200 10 version version NN 10_1101-2020_03_27_012757 200 11 posted post VBD 10_1101-2020_03_27_012757 200 12 January January NNP 10_1101-2020_03_27_012757 200 13 9 9 CD 10_1101-2020_03_27_012757 200 14 , , , 10_1101-2020_03_27_012757 200 15 2021 2021 CD 10_1101-2020_03_27_012757 200 16 . . . 10_1101-2020_03_27_012757 200 17 ; ; : 10_1101-2020_03_27_012757 200 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 200 19 : : : 10_1101-2020_03_27_012757 200 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 200 21 preprint preprint NN 10_1101-2020_03_27_012757 200 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 200 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 200 24 16 16 CD 10_1101-2020_03_27_012757 200 25 hand hand NN 10_1101-2020_03_27_012757 200 26 , , , 10_1101-2020_03_27_012757 200 27 while while IN 10_1101-2020_03_27_012757 200 28 the the DT 10_1101-2020_03_27_012757 200 29 LUAD luad RB 10_1101-2020_03_27_012757 200 30 GEMMs gemm NNS 10_1101-2020_03_27_012757 200 31 classify classify VBP 10_1101-2020_03_27_012757 200 32 strongly strongly RB 10_1101-2020_03_27_012757 200 33 as as RB 10_1101-2020_03_27_012757 200 34 LUAD luad RB 10_1101-2020_03_27_012757 200 35 , , , 10_1101-2020_03_27_012757 200 36 they -PRON- PRP 10_1101-2020_03_27_012757 200 37 do do VBP 10_1101-2020_03_27_012757 200 38 not not RB 10_1101-2020_03_27_012757 200 39 have have VB 10_1101-2020_03_27_012757 200 40 strong strong JJ 10_1101-2020_03_27_012757 200 41 particular particular JJ 10_1101-2020_03_27_012757 200 42 423 423 CD 10_1101-2020_03_27_012757 200 43 subtype subtype NN 10_1101-2020_03_27_012757 200 44 classification classification NN 10_1101-2020_03_27_012757 200 45 -- -- : 10_1101-2020_03_27_012757 200 46 a a DT 10_1101-2020_03_27_012757 200 47 result result NN 10_1101-2020_03_27_012757 200 48 that that WDT 10_1101-2020_03_27_012757 200 49 does do VBZ 10_1101-2020_03_27_012757 200 50 not not RB 10_1101-2020_03_27_012757 200 51 vary vary VB 10_1101-2020_03_27_012757 200 52 by by IN 10_1101-2020_03_27_012757 200 53 genotype genotype NN 10_1101-2020_03_27_012757 200 54 . . . 10_1101-2020_03_27_012757 201 1 424 424 CD 10_1101-2020_03_27_012757 201 2 425 425 CD 10_1101-2020_03_27_012757 201 3 Evaluation Evaluation NNP 10_1101-2020_03_27_012757 201 4 of of IN 10_1101-2020_03_27_012757 201 5 Tumoroids Tumoroids NNP 10_1101-2020_03_27_012757 201 6 426 426 CD 10_1101-2020_03_27_012757 201 7 Lastly lastly RB 10_1101-2020_03_27_012757 201 8 , , , 10_1101-2020_03_27_012757 201 9 we -PRON- PRP 10_1101-2020_03_27_012757 201 10 used use VBD 10_1101-2020_03_27_012757 201 11 CCN CCN NNP 10_1101-2020_03_27_012757 201 12 to to TO 10_1101-2020_03_27_012757 201 13 assess assess VB 10_1101-2020_03_27_012757 201 14 a a DT 10_1101-2020_03_27_012757 201 15 relatively relatively RB 10_1101-2020_03_27_012757 201 16 novel novel JJ 10_1101-2020_03_27_012757 201 17 cancer cancer NN 10_1101-2020_03_27_012757 201 18 model model NN 10_1101-2020_03_27_012757 201 19 : : : 10_1101-2020_03_27_012757 201 20 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 201 21 . . . 10_1101-2020_03_27_012757 202 1 We -PRON- PRP 10_1101-2020_03_27_012757 202 2 427 427 CD 10_1101-2020_03_27_012757 202 3 downloaded download VBN 10_1101-2020_03_27_012757 202 4 and and CC 10_1101-2020_03_27_012757 202 5 assessed assess VBN 10_1101-2020_03_27_012757 202 6 131 131 CD 10_1101-2020_03_27_012757 202 7 distinct distinct JJ 10_1101-2020_03_27_012757 202 8 tumoroid tumoroid NN 10_1101-2020_03_27_012757 202 9 expression expression NN 10_1101-2020_03_27_012757 202 10 profiles profile NNS 10_1101-2020_03_27_012757 202 11 spanning span VBG 10_1101-2020_03_27_012757 202 12 13 13 CD 10_1101-2020_03_27_012757 202 13 cancer cancer NN 10_1101-2020_03_27_012757 202 14 428 428 CD 10_1101-2020_03_27_012757 202 15 categories category NNS 10_1101-2020_03_27_012757 202 16 from from IN 10_1101-2020_03_27_012757 202 17 The the DT 10_1101-2020_03_27_012757 202 18 NCI NCI NNP 10_1101-2020_03_27_012757 202 19 Patient Patient NNP 10_1101-2020_03_27_012757 202 20 - - HYPH 10_1101-2020_03_27_012757 202 21 Derived derive VBN 10_1101-2020_03_27_012757 202 22 Models Models NNP 10_1101-2020_03_27_012757 202 23 Repository Repository NNP 10_1101-2020_03_27_012757 202 24 ( ( -LRB- 10_1101-2020_03_27_012757 202 25 PDMR)69 PDMR)69 NNP 10_1101-2020_03_27_012757 202 26 and and CC 10_1101-2020_03_27_012757 202 27 from from IN 10_1101-2020_03_27_012757 202 28 three three CD 10_1101-2020_03_27_012757 202 29 individual individual JJ 10_1101-2020_03_27_012757 202 30 429 429 CD 10_1101-2020_03_27_012757 202 31 studies70–72 studies70–72 NNS 10_1101-2020_03_27_012757 202 32 ( ( -LRB- 10_1101-2020_03_27_012757 202 33 Fig fig NN 10_1101-2020_03_27_012757 202 34 7A 7a NN 10_1101-2020_03_27_012757 202 35 , , , 10_1101-2020_03_27_012757 202 36 Supp Supp NNP 10_1101-2020_03_27_012757 202 37 Tab Tab NNP 10_1101-2020_03_27_012757 202 38 7 7 CD 10_1101-2020_03_27_012757 202 39 ) ) -RRB- 10_1101-2020_03_27_012757 202 40 . . . 10_1101-2020_03_27_012757 203 1 We -PRON- PRP 10_1101-2020_03_27_012757 203 2 note note VBP 10_1101-2020_03_27_012757 203 3 that that IN 10_1101-2020_03_27_012757 203 4 several several JJ 10_1101-2020_03_27_012757 203 5 categories category NNS 10_1101-2020_03_27_012757 203 6 have have VBP 10_1101-2020_03_27_012757 203 7 three three CD 10_1101-2020_03_27_012757 203 8 or or CC 10_1101-2020_03_27_012757 203 9 fewer few JJR 10_1101-2020_03_27_012757 203 10 samples sample NNS 10_1101-2020_03_27_012757 203 11 430 430 CD 10_1101-2020_03_27_012757 203 12 ( ( -LRB- 10_1101-2020_03_27_012757 203 13 BRCA BRCA NNP 10_1101-2020_03_27_012757 203 14 , , , 10_1101-2020_03_27_012757 203 15 CESC CESC NNP 10_1101-2020_03_27_012757 203 16 , , , 10_1101-2020_03_27_012757 203 17 KIRP KIRP NNP 10_1101-2020_03_27_012757 203 18 , , , 10_1101-2020_03_27_012757 203 19 OV OV NNP 10_1101-2020_03_27_012757 203 20 , , , 10_1101-2020_03_27_012757 203 21 LIHC LIHC NNP 10_1101-2020_03_27_012757 203 22 , , , 10_1101-2020_03_27_012757 203 23 and and CC 10_1101-2020_03_27_012757 203 24 BLCA BLCA NNP 10_1101-2020_03_27_012757 203 25 from from IN 10_1101-2020_03_27_012757 203 26 PDMR PDMR NNP 10_1101-2020_03_27_012757 203 27 ) ) -RRB- 10_1101-2020_03_27_012757 203 28 . . . 10_1101-2020_03_27_012757 204 1 Among among IN 10_1101-2020_03_27_012757 204 2 the the DT 10_1101-2020_03_27_012757 204 3 cancer cancer NN 10_1101-2020_03_27_012757 204 4 categories category NNS 10_1101-2020_03_27_012757 204 5 431 431 CD 10_1101-2020_03_27_012757 204 6 represented represent VBN 10_1101-2020_03_27_012757 204 7 by by IN 10_1101-2020_03_27_012757 204 8 more more JJR 10_1101-2020_03_27_012757 204 9 than than IN 10_1101-2020_03_27_012757 204 10 three three CD 10_1101-2020_03_27_012757 204 11 samples sample NNS 10_1101-2020_03_27_012757 204 12 , , , 10_1101-2020_03_27_012757 204 13 only only RB 10_1101-2020_03_27_012757 204 14 LUSC LUSC NNP 10_1101-2020_03_27_012757 204 15 and and CC 10_1101-2020_03_27_012757 204 16 PAAD PAAD NNS 10_1101-2020_03_27_012757 204 17 have have VBP 10_1101-2020_03_27_012757 204 18 fewer few JJR 10_1101-2020_03_27_012757 204 19 than than IN 10_1101-2020_03_27_012757 204 20 50 50 CD 10_1101-2020_03_27_012757 204 21 % % NN 10_1101-2020_03_27_012757 204 22 classified classify VBD 10_1101-2020_03_27_012757 204 23 432 432 CD 10_1101-2020_03_27_012757 204 24 as as IN 10_1101-2020_03_27_012757 204 25 their -PRON- PRP$ 10_1101-2020_03_27_012757 204 26 annotated annotate VBN 10_1101-2020_03_27_012757 204 27 label label NN 10_1101-2020_03_27_012757 204 28 ( ( -LRB- 10_1101-2020_03_27_012757 204 29 Fig Fig NNP 10_1101-2020_03_27_012757 204 30 7B 7b NN 10_1101-2020_03_27_012757 204 31 ) ) -RRB- 10_1101-2020_03_27_012757 204 32 . . . 10_1101-2020_03_27_012757 205 1 In in IN 10_1101-2020_03_27_012757 205 2 contrast contrast NN 10_1101-2020_03_27_012757 205 3 to to IN 10_1101-2020_03_27_012757 205 4 GBM GBM NNP 10_1101-2020_03_27_012757 205 5 CCLs CCLs NNPS 10_1101-2020_03_27_012757 205 6 , , , 10_1101-2020_03_27_012757 205 7 all all DT 10_1101-2020_03_27_012757 205 8 three three CD 10_1101-2020_03_27_012757 205 9 induced induce VBN 10_1101-2020_03_27_012757 205 10 pluripotent pluripotent NN 10_1101-2020_03_27_012757 205 11 stem stem NN 10_1101-2020_03_27_012757 205 12 433 433 CD 10_1101-2020_03_27_012757 205 13 cell cell NN 10_1101-2020_03_27_012757 205 14 - - HYPH 10_1101-2020_03_27_012757 205 15 derived derive VBN 10_1101-2020_03_27_012757 205 16 GBM GBM NNP 10_1101-2020_03_27_012757 205 17 tumoroids72 tumoroids72 NN 10_1101-2020_03_27_012757 205 18 were be VBD 10_1101-2020_03_27_012757 205 19 classified classify VBN 10_1101-2020_03_27_012757 205 20 as as IN 10_1101-2020_03_27_012757 205 21 GBM GBM NNP 10_1101-2020_03_27_012757 205 22 with with IN 10_1101-2020_03_27_012757 205 23 high high JJ 10_1101-2020_03_27_012757 205 24 CCN CCN NNP 10_1101-2020_03_27_012757 205 25 scores score NNS 10_1101-2020_03_27_012757 205 26 ( ( -LRB- 10_1101-2020_03_27_012757 205 27 mean mean VB 10_1101-2020_03_27_012757 205 28 = = SYM 10_1101-2020_03_27_012757 205 29 0.53 0.53 CD 10_1101-2020_03_27_012757 205 30 ) ) -RRB- 10_1101-2020_03_27_012757 205 31 . . . 10_1101-2020_03_27_012757 206 1 To to IN 10_1101-2020_03_27_012757 206 2 434 434 CD 10_1101-2020_03_27_012757 206 3 further further RB 10_1101-2020_03_27_012757 206 4 characterize characterize VB 10_1101-2020_03_27_012757 206 5 the the DT 10_1101-2020_03_27_012757 206 6 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 206 7 , , , 10_1101-2020_03_27_012757 206 8 we -PRON- PRP 10_1101-2020_03_27_012757 206 9 performed perform VBD 10_1101-2020_03_27_012757 206 10 subtype subtype NN 10_1101-2020_03_27_012757 206 11 classification classification NN 10_1101-2020_03_27_012757 206 12 on on IN 10_1101-2020_03_27_012757 206 13 them -PRON- PRP 10_1101-2020_03_27_012757 206 14 ( ( -LRB- 10_1101-2020_03_27_012757 206 15 Supp Supp NNP 10_1101-2020_03_27_012757 206 16 Tab Tab NNP 10_1101-2020_03_27_012757 206 17 8) 8) CD 10_1101-2020_03_27_012757 206 18 . . . 10_1101-2020_03_27_012757 207 1 435 435 CD 10_1101-2020_03_27_012757 207 2 UCEC UCEC NNP 10_1101-2020_03_27_012757 207 3 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 207 4 from from IN 10_1101-2020_03_27_012757 207 5 PDMR PDMR NNP 10_1101-2020_03_27_012757 207 6 contains contain VBZ 10_1101-2020_03_27_012757 207 7 a a DT 10_1101-2020_03_27_012757 207 8 wide wide JJ 10_1101-2020_03_27_012757 207 9 range range NN 10_1101-2020_03_27_012757 207 10 of of IN 10_1101-2020_03_27_012757 207 11 subtypes subtype NNS 10_1101-2020_03_27_012757 207 12 with with IN 10_1101-2020_03_27_012757 207 13 two two CD 10_1101-2020_03_27_012757 207 14 endometrioid endometrioid NN 10_1101-2020_03_27_012757 207 15 , , , 10_1101-2020_03_27_012757 207 16 two two CD 10_1101-2020_03_27_012757 207 17 436 436 CD 10_1101-2020_03_27_012757 207 18 serous serous JJ 10_1101-2020_03_27_012757 207 19 and and CC 10_1101-2020_03_27_012757 207 20 one one CD 10_1101-2020_03_27_012757 207 21 mixed mix VBN 10_1101-2020_03_27_012757 207 22 type type NN 10_1101-2020_03_27_012757 207 23 ( ( -LRB- 10_1101-2020_03_27_012757 207 24 Fig Fig NNP 10_1101-2020_03_27_012757 207 25 7C 7C NNP 10_1101-2020_03_27_012757 207 26 ) ) -RRB- 10_1101-2020_03_27_012757 207 27 . . . 10_1101-2020_03_27_012757 208 1 On on IN 10_1101-2020_03_27_012757 208 2 the the DT 10_1101-2020_03_27_012757 208 3 other other JJ 10_1101-2020_03_27_012757 208 4 hand hand NN 10_1101-2020_03_27_012757 208 5 , , , 10_1101-2020_03_27_012757 208 6 LUSC LUSC NNP 10_1101-2020_03_27_012757 208 7 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 208 8 appear appear VBP 10_1101-2020_03_27_012757 208 9 to to TO 10_1101-2020_03_27_012757 208 10 be be VB 10_1101-2020_03_27_012757 208 11 437 437 CD 10_1101-2020_03_27_012757 208 12 predominantly predominantly RB 10_1101-2020_03_27_012757 208 13 of of IN 10_1101-2020_03_27_012757 208 14 classical classical JJ 10_1101-2020_03_27_012757 208 15 subtypes subtype NNS 10_1101-2020_03_27_012757 208 16 with with IN 10_1101-2020_03_27_012757 208 17 one one CD 10_1101-2020_03_27_012757 208 18 tumoroid tumoroid NN 10_1101-2020_03_27_012757 208 19 classified classify VBD 10_1101-2020_03_27_012757 208 20 as as IN 10_1101-2020_03_27_012757 208 21 a a DT 10_1101-2020_03_27_012757 208 22 mix mix NN 10_1101-2020_03_27_012757 208 23 between between IN 10_1101-2020_03_27_012757 208 24 classical classical JJ 10_1101-2020_03_27_012757 208 25 and and CC 10_1101-2020_03_27_012757 208 26 438 438 CD 10_1101-2020_03_27_012757 208 27 primitive primitive JJ 10_1101-2020_03_27_012757 208 28 ( ( -LRB- 10_1101-2020_03_27_012757 208 29 Fig fig NN 10_1101-2020_03_27_012757 208 30 7D 7d NN 10_1101-2020_03_27_012757 208 31 ) ) -RRB- 10_1101-2020_03_27_012757 208 32 . . . 10_1101-2020_03_27_012757 209 1 Lastly lastly RB 10_1101-2020_03_27_012757 209 2 , , , 10_1101-2020_03_27_012757 209 3 similar similar JJ 10_1101-2020_03_27_012757 209 4 to to IN 10_1101-2020_03_27_012757 209 5 the the DT 10_1101-2020_03_27_012757 209 6 CCL CCL NNP 10_1101-2020_03_27_012757 209 7 and and CC 10_1101-2020_03_27_012757 209 8 PDX PDX NNP 10_1101-2020_03_27_012757 209 9 counterparts counterpart NNS 10_1101-2020_03_27_012757 209 10 , , , 10_1101-2020_03_27_012757 209 11 LUAD luad RB 10_1101-2020_03_27_012757 209 12 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 209 13 are be VBP 10_1101-2020_03_27_012757 209 14 439 439 CD 10_1101-2020_03_27_012757 209 15 classified classify VBN 10_1101-2020_03_27_012757 209 16 as as IN 10_1101-2020_03_27_012757 209 17 proximal proximal JJ 10_1101-2020_03_27_012757 209 18 inflammatory inflammatory JJ 10_1101-2020_03_27_012757 209 19 and and CC 10_1101-2020_03_27_012757 209 20 proximal proximal JJ 10_1101-2020_03_27_012757 209 21 proliferation proliferation NN 10_1101-2020_03_27_012757 209 22 with with IN 10_1101-2020_03_27_012757 209 23 no no DT 10_1101-2020_03_27_012757 209 24 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 209 25 classified classify VBN 10_1101-2020_03_27_012757 209 26 as as IN 10_1101-2020_03_27_012757 209 27 440 440 CD 10_1101-2020_03_27_012757 209 28 TRU tru NN 10_1101-2020_03_27_012757 209 29 subtype subtype NN 10_1101-2020_03_27_012757 209 30 ( ( -LRB- 10_1101-2020_03_27_012757 209 31 Fig fig NN 10_1101-2020_03_27_012757 209 32 7E 7e NN 10_1101-2020_03_27_012757 209 33 ) ) -RRB- 10_1101-2020_03_27_012757 209 34 . . . 10_1101-2020_03_27_012757 210 1 441 441 CD 10_1101-2020_03_27_012757 210 2 442 442 CD 10_1101-2020_03_27_012757 210 3 Comparison Comparison NNP 10_1101-2020_03_27_012757 210 4 of of IN 10_1101-2020_03_27_012757 210 5 CCLs CCLs NNPS 10_1101-2020_03_27_012757 210 6 , , , 10_1101-2020_03_27_012757 210 7 PDXs pdx NNS 10_1101-2020_03_27_012757 210 8 , , , 10_1101-2020_03_27_012757 210 9 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 210 10 and and CC 10_1101-2020_03_27_012757 210 11 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 210 12 443 443 CD 10_1101-2020_03_27_012757 210 13 Finally finally RB 10_1101-2020_03_27_012757 210 14 , , , 10_1101-2020_03_27_012757 210 15 we -PRON- PRP 10_1101-2020_03_27_012757 210 16 sought seek VBD 10_1101-2020_03_27_012757 210 17 to to TO 10_1101-2020_03_27_012757 210 18 estimate estimate VB 10_1101-2020_03_27_012757 210 19 the the DT 10_1101-2020_03_27_012757 210 20 comparative comparative JJ 10_1101-2020_03_27_012757 210 21 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 210 22 fidelity fidelity NN 10_1101-2020_03_27_012757 210 23 of of IN 10_1101-2020_03_27_012757 210 24 the the DT 10_1101-2020_03_27_012757 210 25 four four CD 10_1101-2020_03_27_012757 210 26 cancer cancer NN 10_1101-2020_03_27_012757 210 27 444 444 CD 10_1101-2020_03_27_012757 210 28 models model NNS 10_1101-2020_03_27_012757 210 29 modalities modality NNS 10_1101-2020_03_27_012757 210 30 . . . 10_1101-2020_03_27_012757 211 1 We -PRON- PRP 10_1101-2020_03_27_012757 211 2 compared compare VBD 10_1101-2020_03_27_012757 211 3 the the DT 10_1101-2020_03_27_012757 211 4 general general JJ 10_1101-2020_03_27_012757 211 5 CCN CCN NNP 10_1101-2020_03_27_012757 211 6 scores score NNS 10_1101-2020_03_27_012757 211 7 of of IN 10_1101-2020_03_27_012757 211 8 each each DT 10_1101-2020_03_27_012757 211 9 model model NN 10_1101-2020_03_27_012757 211 10 on on IN 10_1101-2020_03_27_012757 211 11 a a DT 10_1101-2020_03_27_012757 211 12 per per FW 10_1101-2020_03_27_012757 211 13 tumor tumor NN 10_1101-2020_03_27_012757 211 14 type type NN 10_1101-2020_03_27_012757 211 15 445 445 CD 10_1101-2020_03_27_012757 211 16 basis basis NN 10_1101-2020_03_27_012757 211 17 ( ( -LRB- 10_1101-2020_03_27_012757 211 18 Fig fig NN 10_1101-2020_03_27_012757 211 19 8) 8) CD 10_1101-2020_03_27_012757 211 20 . . . 10_1101-2020_03_27_012757 212 1 In in IN 10_1101-2020_03_27_012757 212 2 the the DT 10_1101-2020_03_27_012757 212 3 case case NN 10_1101-2020_03_27_012757 212 4 of of IN 10_1101-2020_03_27_012757 212 5 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 212 6 , , , 10_1101-2020_03_27_012757 212 7 we -PRON- PRP 10_1101-2020_03_27_012757 212 8 used use VBD 10_1101-2020_03_27_012757 212 9 the the DT 10_1101-2020_03_27_012757 212 10 mean mean JJ 10_1101-2020_03_27_012757 212 11 classification classification NN 10_1101-2020_03_27_012757 212 12 score score NN 10_1101-2020_03_27_012757 212 13 of of IN 10_1101-2020_03_27_012757 212 14 all all DT 10_1101-2020_03_27_012757 212 15 samples sample NNS 10_1101-2020_03_27_012757 212 16 with with IN 10_1101-2020_03_27_012757 212 17 446 446 CD 10_1101-2020_03_27_012757 212 18 shared shared JJ 10_1101-2020_03_27_012757 212 19 genotypes genotype NNS 10_1101-2020_03_27_012757 212 20 . . . 10_1101-2020_03_27_012757 213 1 We -PRON- PRP 10_1101-2020_03_27_012757 213 2 also also RB 10_1101-2020_03_27_012757 213 3 used use VBD 10_1101-2020_03_27_012757 213 4 mean mean VBP 10_1101-2020_03_27_012757 213 5 classification classification NN 10_1101-2020_03_27_012757 213 6 of of IN 10_1101-2020_03_27_012757 213 7 technical technical JJ 10_1101-2020_03_27_012757 213 8 replicates replicate NNS 10_1101-2020_03_27_012757 213 9 found find VBN 10_1101-2020_03_27_012757 213 10 in in IN 10_1101-2020_03_27_012757 213 11 LIHC LIHC NNP 10_1101-2020_03_27_012757 213 12 447 447 CD 10_1101-2020_03_27_012757 213 13 tumoroids70 tumoroids70 NN 10_1101-2020_03_27_012757 213 14 . . . 10_1101-2020_03_27_012757 214 1 We -PRON- PRP 10_1101-2020_03_27_012757 214 2 evaluated evaluate VBD 10_1101-2020_03_27_012757 214 3 models model NNS 10_1101-2020_03_27_012757 214 4 based base VBN 10_1101-2020_03_27_012757 214 5 on on IN 10_1101-2020_03_27_012757 214 6 both both CC 10_1101-2020_03_27_012757 214 7 the the DT 10_1101-2020_03_27_012757 214 8 maximum maximum JJ 10_1101-2020_03_27_012757 214 9 CCN CCN NNP 10_1101-2020_03_27_012757 214 10 score score NN 10_1101-2020_03_27_012757 214 11 , , , 10_1101-2020_03_27_012757 214 12 as as IN 10_1101-2020_03_27_012757 214 13 this this DT 10_1101-2020_03_27_012757 214 14 represents represent VBZ 10_1101-2020_03_27_012757 214 15 448 448 CD 10_1101-2020_03_27_012757 214 16 .CC .CC : 10_1101-2020_03_27_012757 214 17 - - HYPH 10_1101-2020_03_27_012757 214 18 BY by IN 10_1101-2020_03_27_012757 214 19 - - HYPH 10_1101-2020_03_27_012757 214 20 NC NC NNP 10_1101-2020_03_27_012757 214 21 - - HYPH 10_1101-2020_03_27_012757 214 22 ND ND NNP 10_1101-2020_03_27_012757 214 23 4.0 4.0 CD 10_1101-2020_03_27_012757 214 24 International International NNP 10_1101-2020_03_27_012757 214 25 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 214 26 under under IN 10_1101-2020_03_27_012757 214 27 a a DT 10_1101-2020_03_27_012757 214 28 ( ( -LRB- 10_1101-2020_03_27_012757 214 29 which which WDT 10_1101-2020_03_27_012757 214 30 was be VBD 10_1101-2020_03_27_012757 214 31 not not RB 10_1101-2020_03_27_012757 214 32 certified certify VBN 10_1101-2020_03_27_012757 214 33 by by IN 10_1101-2020_03_27_012757 214 34 peer peer NN 10_1101-2020_03_27_012757 214 35 review review NN 10_1101-2020_03_27_012757 214 36 ) ) -RRB- 10_1101-2020_03_27_012757 214 37 is be VBZ 10_1101-2020_03_27_012757 214 38 the the DT 10_1101-2020_03_27_012757 214 39 author author NN 10_1101-2020_03_27_012757 214 40 / / SYM 10_1101-2020_03_27_012757 214 41 funder funder NN 10_1101-2020_03_27_012757 214 42 , , , 10_1101-2020_03_27_012757 214 43 who who WP 10_1101-2020_03_27_012757 214 44 has have VBZ 10_1101-2020_03_27_012757 214 45 granted grant VBN 10_1101-2020_03_27_012757 214 46 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 214 47 a a DT 10_1101-2020_03_27_012757 214 48 license license NN 10_1101-2020_03_27_012757 214 49 to to TO 10_1101-2020_03_27_012757 214 50 display display VB 10_1101-2020_03_27_012757 214 51 the the DT 10_1101-2020_03_27_012757 214 52 preprint preprint NN 10_1101-2020_03_27_012757 214 53 in in IN 10_1101-2020_03_27_012757 214 54 perpetuity perpetuity NN 10_1101-2020_03_27_012757 214 55 . . . 10_1101-2020_03_27_012757 215 1 It -PRON- PRP 10_1101-2020_03_27_012757 215 2 is be VBZ 10_1101-2020_03_27_012757 215 3 made make VBN 10_1101-2020_03_27_012757 215 4 The the DT 10_1101-2020_03_27_012757 215 5 copyright copyright NN 10_1101-2020_03_27_012757 215 6 holder holder NN 10_1101-2020_03_27_012757 215 7 for for IN 10_1101-2020_03_27_012757 215 8 this this DT 10_1101-2020_03_27_012757 215 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 215 10 version version NN 10_1101-2020_03_27_012757 215 11 posted post VBD 10_1101-2020_03_27_012757 215 12 January January NNP 10_1101-2020_03_27_012757 215 13 9 9 CD 10_1101-2020_03_27_012757 215 14 , , , 10_1101-2020_03_27_012757 215 15 2021 2021 CD 10_1101-2020_03_27_012757 215 16 . . . 10_1101-2020_03_27_012757 215 17 ; ; : 10_1101-2020_03_27_012757 215 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 215 19 : : : 10_1101-2020_03_27_012757 215 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 215 21 preprint preprint NN 10_1101-2020_03_27_012757 215 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 215 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 215 24 17 17 CD 10_1101-2020_03_27_012757 215 25 the the DT 10_1101-2020_03_27_012757 215 26 potential potential NN 10_1101-2020_03_27_012757 215 27 for for IN 10_1101-2020_03_27_012757 215 28 a a DT 10_1101-2020_03_27_012757 215 29 model model NN 10_1101-2020_03_27_012757 215 30 class class NN 10_1101-2020_03_27_012757 215 31 , , , 10_1101-2020_03_27_012757 215 32 and and CC 10_1101-2020_03_27_012757 215 33 the the DT 10_1101-2020_03_27_012757 215 34 median median JJ 10_1101-2020_03_27_012757 215 35 CCN CCN NNP 10_1101-2020_03_27_012757 215 36 score score NN 10_1101-2020_03_27_012757 215 37 , , , 10_1101-2020_03_27_012757 215 38 as as IN 10_1101-2020_03_27_012757 215 39 this this DT 10_1101-2020_03_27_012757 215 40 indicates indicate VBZ 10_1101-2020_03_27_012757 215 41 the the DT 10_1101-2020_03_27_012757 215 42 current current JJ 10_1101-2020_03_27_012757 215 43 overall overall RB 10_1101-2020_03_27_012757 215 44 449 449 CD 10_1101-2020_03_27_012757 215 45 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 215 46 fidelity fidelity NN 10_1101-2020_03_27_012757 215 47 of of IN 10_1101-2020_03_27_012757 215 48 a a DT 10_1101-2020_03_27_012757 215 49 model model NN 10_1101-2020_03_27_012757 215 50 class class NN 10_1101-2020_03_27_012757 215 51 . . . 10_1101-2020_03_27_012757 216 1 PDXs pdx NNS 10_1101-2020_03_27_012757 216 2 achieved achieve VBD 10_1101-2020_03_27_012757 216 3 the the DT 10_1101-2020_03_27_012757 216 4 highest high JJS 10_1101-2020_03_27_012757 216 5 CCN CCN NNP 10_1101-2020_03_27_012757 216 6 scores score NNS 10_1101-2020_03_27_012757 216 7 in in IN 10_1101-2020_03_27_012757 216 8 three three CD 10_1101-2020_03_27_012757 216 9 ( ( -LRB- 10_1101-2020_03_27_012757 216 10 UCEC UCEC NNP 10_1101-2020_03_27_012757 216 11 , , , 10_1101-2020_03_27_012757 216 12 450 450 CD 10_1101-2020_03_27_012757 216 13 PAAD PAAD NNS 10_1101-2020_03_27_012757 216 14 , , , 10_1101-2020_03_27_012757 216 15 LUAD luad RB 10_1101-2020_03_27_012757 216 16 ) ) -RRB- 10_1101-2020_03_27_012757 216 17 out out IN 10_1101-2020_03_27_012757 216 18 of of IN 10_1101-2020_03_27_012757 216 19 the the DT 10_1101-2020_03_27_012757 216 20 five five CD 10_1101-2020_03_27_012757 216 21 cancer cancer NN 10_1101-2020_03_27_012757 216 22 categories category NNS 10_1101-2020_03_27_012757 216 23 in in IN 10_1101-2020_03_27_012757 216 24 which which WDT 10_1101-2020_03_27_012757 216 25 all all DT 10_1101-2020_03_27_012757 216 26 four four CD 10_1101-2020_03_27_012757 216 27 modalities modality NNS 10_1101-2020_03_27_012757 216 28 were be VBD 10_1101-2020_03_27_012757 216 29 available available JJ 10_1101-2020_03_27_012757 216 30 ( ( -LRB- 10_1101-2020_03_27_012757 216 31 Fig fig NN 10_1101-2020_03_27_012757 216 32 451 451 CD 10_1101-2020_03_27_012757 216 33 8) 8) CD 10_1101-2020_03_27_012757 216 34 , , , 10_1101-2020_03_27_012757 216 35 despite despite IN 10_1101-2020_03_27_012757 216 36 having have VBG 10_1101-2020_03_27_012757 216 37 low low JJ 10_1101-2020_03_27_012757 216 38 median median JJ 10_1101-2020_03_27_012757 216 39 CCN CCN NNP 10_1101-2020_03_27_012757 216 40 scores score NNS 10_1101-2020_03_27_012757 216 41 . . . 10_1101-2020_03_27_012757 217 1 Notably notably RB 10_1101-2020_03_27_012757 217 2 , , , 10_1101-2020_03_27_012757 217 3 PDXs pdx NNS 10_1101-2020_03_27_012757 217 4 have have VBP 10_1101-2020_03_27_012757 217 5 a a DT 10_1101-2020_03_27_012757 217 6 median median JJ 10_1101-2020_03_27_012757 217 7 CCN ccn NN 10_1101-2020_03_27_012757 217 8 score score NN 10_1101-2020_03_27_012757 217 9 above above IN 10_1101-2020_03_27_012757 217 10 452 452 CD 10_1101-2020_03_27_012757 217 11 the the DT 10_1101-2020_03_27_012757 217 12 0.25 0.25 CD 10_1101-2020_03_27_012757 217 13 threshold threshold NN 10_1101-2020_03_27_012757 217 14 in in IN 10_1101-2020_03_27_012757 217 15 PAAD PAAD NNP 10_1101-2020_03_27_012757 217 16 while while IN 10_1101-2020_03_27_012757 217 17 none none NN 10_1101-2020_03_27_012757 217 18 of of IN 10_1101-2020_03_27_012757 217 19 the the DT 10_1101-2020_03_27_012757 217 20 other other JJ 10_1101-2020_03_27_012757 217 21 three three CD 10_1101-2020_03_27_012757 217 22 modalities modality NNS 10_1101-2020_03_27_012757 217 23 have have VBP 10_1101-2020_03_27_012757 217 24 any any DT 10_1101-2020_03_27_012757 217 25 samples sample NNS 10_1101-2020_03_27_012757 217 26 above above IN 10_1101-2020_03_27_012757 217 27 453 453 CD 10_1101-2020_03_27_012757 217 28 the the DT 10_1101-2020_03_27_012757 217 29 threshold threshold NN 10_1101-2020_03_27_012757 217 30 . . . 10_1101-2020_03_27_012757 218 1 In in IN 10_1101-2020_03_27_012757 218 2 LIHC LIHC NNP 10_1101-2020_03_27_012757 218 3 , , , 10_1101-2020_03_27_012757 218 4 the the DT 10_1101-2020_03_27_012757 218 5 highest high JJS 10_1101-2020_03_27_012757 218 6 CCN CCN NNP 10_1101-2020_03_27_012757 218 7 score score NN 10_1101-2020_03_27_012757 218 8 for for IN 10_1101-2020_03_27_012757 218 9 PDX PDX NNP 10_1101-2020_03_27_012757 218 10 ( ( -LRB- 10_1101-2020_03_27_012757 218 11 0.9 0.9 CD 10_1101-2020_03_27_012757 218 12 ) ) -RRB- 10_1101-2020_03_27_012757 218 13 is be VBZ 10_1101-2020_03_27_012757 218 14 only only RB 10_1101-2020_03_27_012757 218 15 slightly slightly RB 10_1101-2020_03_27_012757 218 16 lower low JJR 10_1101-2020_03_27_012757 218 17 than than IN 10_1101-2020_03_27_012757 218 18 the the DT 10_1101-2020_03_27_012757 218 19 454 454 CD 10_1101-2020_03_27_012757 218 20 highest high JJS 10_1101-2020_03_27_012757 218 21 CCN CCN NNP 10_1101-2020_03_27_012757 218 22 score score NN 10_1101-2020_03_27_012757 218 23 for for IN 10_1101-2020_03_27_012757 218 24 tumoroid tumoroid NN 10_1101-2020_03_27_012757 218 25 ( ( -LRB- 10_1101-2020_03_27_012757 218 26 0.91 0.91 CD 10_1101-2020_03_27_012757 218 27 ) ) -RRB- 10_1101-2020_03_27_012757 218 28 . . . 10_1101-2020_03_27_012757 219 1 This this DT 10_1101-2020_03_27_012757 219 2 suggest suggest VBP 10_1101-2020_03_27_012757 219 3 that that IN 10_1101-2020_03_27_012757 219 4 certain certain JJ 10_1101-2020_03_27_012757 219 5 individual individual JJ 10_1101-2020_03_27_012757 219 6 PDXs pdx NNS 10_1101-2020_03_27_012757 219 7 most most RBS 10_1101-2020_03_27_012757 219 8 closely closely RB 10_1101-2020_03_27_012757 219 9 455 455 CD 10_1101-2020_03_27_012757 219 10 mimic mimic NN 10_1101-2020_03_27_012757 219 11 the the DT 10_1101-2020_03_27_012757 219 12 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 219 13 state state NN 10_1101-2020_03_27_012757 219 14 of of IN 10_1101-2020_03_27_012757 219 15 native native JJ 10_1101-2020_03_27_012757 219 16 patient patient JJ 10_1101-2020_03_27_012757 219 17 tumors tumor NNS 10_1101-2020_03_27_012757 219 18 despite despite IN 10_1101-2020_03_27_012757 219 19 a a DT 10_1101-2020_03_27_012757 219 20 portion portion NN 10_1101-2020_03_27_012757 219 21 of of IN 10_1101-2020_03_27_012757 219 22 the the DT 10_1101-2020_03_27_012757 219 23 PDXs pdx NNS 10_1101-2020_03_27_012757 219 24 having have VBG 10_1101-2020_03_27_012757 219 25 low low JJ 10_1101-2020_03_27_012757 219 26 456 456 CD 10_1101-2020_03_27_012757 219 27 CCN ccn NN 10_1101-2020_03_27_012757 219 28 scores score NNS 10_1101-2020_03_27_012757 219 29 . . . 10_1101-2020_03_27_012757 220 1 Similarly similarly RB 10_1101-2020_03_27_012757 220 2 , , , 10_1101-2020_03_27_012757 220 3 while while IN 10_1101-2020_03_27_012757 220 4 the the DT 10_1101-2020_03_27_012757 220 5 majority majority NN 10_1101-2020_03_27_012757 220 6 of of IN 10_1101-2020_03_27_012757 220 7 the the DT 10_1101-2020_03_27_012757 220 8 CCLs ccl NNS 10_1101-2020_03_27_012757 220 9 have have VBP 10_1101-2020_03_27_012757 220 10 low low JJ 10_1101-2020_03_27_012757 220 11 CCN CCN NNP 10_1101-2020_03_27_012757 220 12 scores score NNS 10_1101-2020_03_27_012757 220 13 , , , 10_1101-2020_03_27_012757 220 14 several several JJ 10_1101-2020_03_27_012757 220 15 lines line NNS 10_1101-2020_03_27_012757 220 16 457 457 CD 10_1101-2020_03_27_012757 220 17 achieve achieve VBP 10_1101-2020_03_27_012757 220 18 high high JJ 10_1101-2020_03_27_012757 220 19 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 220 20 fidelity fidelity NN 10_1101-2020_03_27_012757 220 21 in in IN 10_1101-2020_03_27_012757 220 22 LUSC LUSC NNP 10_1101-2020_03_27_012757 220 23 , , , 10_1101-2020_03_27_012757 220 24 LUAD LUAD NNP 10_1101-2020_03_27_012757 220 25 and and CC 10_1101-2020_03_27_012757 220 26 LIHC LIHC NNP 10_1101-2020_03_27_012757 220 27 ( ( -LRB- 10_1101-2020_03_27_012757 220 28 Fig Fig NNP 10_1101-2020_03_27_012757 220 29 8) 8) CD 10_1101-2020_03_27_012757 220 30 . . . 10_1101-2020_03_27_012757 221 1 Collectively collectively RB 10_1101-2020_03_27_012757 221 2 , , , 10_1101-2020_03_27_012757 221 3 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 221 4 and and CC 10_1101-2020_03_27_012757 221 5 458 458 CD 10_1101-2020_03_27_012757 221 6 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 221 7 had have VBD 10_1101-2020_03_27_012757 221 8 the the DT 10_1101-2020_03_27_012757 221 9 highest high JJS 10_1101-2020_03_27_012757 221 10 median median JJ 10_1101-2020_03_27_012757 221 11 CCN CCN NNP 10_1101-2020_03_27_012757 221 12 scores score NNS 10_1101-2020_03_27_012757 221 13 in in IN 10_1101-2020_03_27_012757 221 14 four four CD 10_1101-2020_03_27_012757 221 15 of of IN 10_1101-2020_03_27_012757 221 16 the the DT 10_1101-2020_03_27_012757 221 17 five five CD 10_1101-2020_03_27_012757 221 18 model model NN 10_1101-2020_03_27_012757 221 19 classes class NNS 10_1101-2020_03_27_012757 221 20 ( ( -LRB- 10_1101-2020_03_27_012757 221 21 LUSC LUSC NNP 10_1101-2020_03_27_012757 221 22 and and CC 10_1101-2020_03_27_012757 221 23 459 459 CD 10_1101-2020_03_27_012757 221 24 LUAD luad RB 10_1101-2020_03_27_012757 221 25 for for IN 10_1101-2020_03_27_012757 221 26 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 221 27 and and CC 10_1101-2020_03_27_012757 221 28 UCEC UCEC NNP 10_1101-2020_03_27_012757 221 29 and and CC 10_1101-2020_03_27_012757 221 30 LIHC LIHC NNP 10_1101-2020_03_27_012757 221 31 for for IN 10_1101-2020_03_27_012757 221 32 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 221 33 ) ) -RRB- 10_1101-2020_03_27_012757 221 34 . . . 10_1101-2020_03_27_012757 222 1 Notably notably RB 10_1101-2020_03_27_012757 222 2 , , , 10_1101-2020_03_27_012757 222 3 both both DT 10_1101-2020_03_27_012757 222 4 of of IN 10_1101-2020_03_27_012757 222 5 the the DT 10_1101-2020_03_27_012757 222 6 LIHC LIHC NNP 10_1101-2020_03_27_012757 222 7 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 222 8 460 460 CD 10_1101-2020_03_27_012757 222 9 achieved achieve VBD 10_1101-2020_03_27_012757 222 10 CCN CCN NNP 10_1101-2020_03_27_012757 222 11 scores score NNS 10_1101-2020_03_27_012757 222 12 on on IN 10_1101-2020_03_27_012757 222 13 par par NN 10_1101-2020_03_27_012757 222 14 with with IN 10_1101-2020_03_27_012757 222 15 patient patient JJ 10_1101-2020_03_27_012757 222 16 tumors tumor NNS 10_1101-2020_03_27_012757 222 17 ( ( -LRB- 10_1101-2020_03_27_012757 222 18 Fig fig NN 10_1101-2020_03_27_012757 222 19 8) 8) CD 10_1101-2020_03_27_012757 222 20 . . . 10_1101-2020_03_27_012757 223 1 In in IN 10_1101-2020_03_27_012757 223 2 brief brief NN 10_1101-2020_03_27_012757 223 3 , , , 10_1101-2020_03_27_012757 223 4 this this DT 10_1101-2020_03_27_012757 223 5 analysis analysis NN 10_1101-2020_03_27_012757 223 6 indicates indicate VBZ 10_1101-2020_03_27_012757 223 7 that that IN 10_1101-2020_03_27_012757 223 8 461 461 CD 10_1101-2020_03_27_012757 223 9 PDXs pdx NNS 10_1101-2020_03_27_012757 223 10 and and CC 10_1101-2020_03_27_012757 223 11 CCLs ccl NNS 10_1101-2020_03_27_012757 223 12 are be VBP 10_1101-2020_03_27_012757 223 13 heterogenous heterogenous JJ 10_1101-2020_03_27_012757 223 14 in in IN 10_1101-2020_03_27_012757 223 15 terms term NNS 10_1101-2020_03_27_012757 223 16 of of IN 10_1101-2020_03_27_012757 223 17 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 223 18 fidelity fidelity NN 10_1101-2020_03_27_012757 223 19 , , , 10_1101-2020_03_27_012757 223 20 with with IN 10_1101-2020_03_27_012757 223 21 a a DT 10_1101-2020_03_27_012757 223 22 portion portion NN 10_1101-2020_03_27_012757 223 23 of of IN 10_1101-2020_03_27_012757 223 24 the the DT 10_1101-2020_03_27_012757 223 25 462 462 CD 10_1101-2020_03_27_012757 223 26 models model NNS 10_1101-2020_03_27_012757 223 27 highly highly RB 10_1101-2020_03_27_012757 223 28 mimicking mimic VBG 10_1101-2020_03_27_012757 223 29 native native JJ 10_1101-2020_03_27_012757 223 30 tumors tumor NNS 10_1101-2020_03_27_012757 223 31 and and CC 10_1101-2020_03_27_012757 223 32 the the DT 10_1101-2020_03_27_012757 223 33 majority majority NN 10_1101-2020_03_27_012757 223 34 of of IN 10_1101-2020_03_27_012757 223 35 the the DT 10_1101-2020_03_27_012757 223 36 models model NNS 10_1101-2020_03_27_012757 223 37 having have VBG 10_1101-2020_03_27_012757 223 38 low low JJ 10_1101-2020_03_27_012757 223 39 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 223 40 463 463 CD 10_1101-2020_03_27_012757 223 41 fidelity fidelity NN 10_1101-2020_03_27_012757 223 42 ( ( -LRB- 10_1101-2020_03_27_012757 223 43 with with IN 10_1101-2020_03_27_012757 223 44 the the DT 10_1101-2020_03_27_012757 223 45 exception exception NN 10_1101-2020_03_27_012757 223 46 of of IN 10_1101-2020_03_27_012757 223 47 PAAD PAAD NNP 10_1101-2020_03_27_012757 223 48 for for IN 10_1101-2020_03_27_012757 223 49 PDXs pdx NNS 10_1101-2020_03_27_012757 223 50 ) ) -RRB- 10_1101-2020_03_27_012757 223 51 . . . 10_1101-2020_03_27_012757 224 1 On on IN 10_1101-2020_03_27_012757 224 2 the the DT 10_1101-2020_03_27_012757 224 3 other other JJ 10_1101-2020_03_27_012757 224 4 hand hand NN 10_1101-2020_03_27_012757 224 5 , , , 10_1101-2020_03_27_012757 224 6 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 224 7 and and CC 10_1101-2020_03_27_012757 224 8 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 224 9 464 464 CD 10_1101-2020_03_27_012757 224 10 displayed display VBD 10_1101-2020_03_27_012757 224 11 a a DT 10_1101-2020_03_27_012757 224 12 consistently consistently RB 10_1101-2020_03_27_012757 224 13 high high JJ 10_1101-2020_03_27_012757 224 14 fidelity fidelity NN 10_1101-2020_03_27_012757 224 15 across across IN 10_1101-2020_03_27_012757 224 16 different different JJ 10_1101-2020_03_27_012757 224 17 models model NNS 10_1101-2020_03_27_012757 224 18 . . . 10_1101-2020_03_27_012757 225 1 465 465 CD 10_1101-2020_03_27_012757 225 2 Because because IN 10_1101-2020_03_27_012757 225 3 the the DT 10_1101-2020_03_27_012757 225 4 CCN CCN NNP 10_1101-2020_03_27_012757 225 5 score score NN 10_1101-2020_03_27_012757 225 6 is be VBZ 10_1101-2020_03_27_012757 225 7 based base VBN 10_1101-2020_03_27_012757 225 8 on on IN 10_1101-2020_03_27_012757 225 9 a a DT 10_1101-2020_03_27_012757 225 10 moderate moderate JJ 10_1101-2020_03_27_012757 225 11 number number NN 10_1101-2020_03_27_012757 225 12 of of IN 10_1101-2020_03_27_012757 225 13 gene gene NN 10_1101-2020_03_27_012757 225 14 features feature NNS 10_1101-2020_03_27_012757 225 15 ( ( -LRB- 10_1101-2020_03_27_012757 225 16 i.e. i.e. FW 10_1101-2020_03_27_012757 226 1 1,979 1,979 CD 10_1101-2020_03_27_012757 226 2 466 466 CD 10_1101-2020_03_27_012757 226 3 gene gene NN 10_1101-2020_03_27_012757 226 4 pairs pair NNS 10_1101-2020_03_27_012757 226 5 consisting consist VBG 10_1101-2020_03_27_012757 226 6 of of IN 10_1101-2020_03_27_012757 226 7 1,689 1,689 CD 10_1101-2020_03_27_012757 226 8 unique unique JJ 10_1101-2020_03_27_012757 226 9 genes gene NNS 10_1101-2020_03_27_012757 226 10 ) ) -RRB- 10_1101-2020_03_27_012757 226 11 relative relative JJ 10_1101-2020_03_27_012757 226 12 to to IN 10_1101-2020_03_27_012757 226 13 the the DT 10_1101-2020_03_27_012757 226 14 total total JJ 10_1101-2020_03_27_012757 226 15 number number NN 10_1101-2020_03_27_012757 226 16 of of IN 10_1101-2020_03_27_012757 226 17 protein protein NN 10_1101-2020_03_27_012757 226 18 - - HYPH 10_1101-2020_03_27_012757 226 19 coding code VBG 10_1101-2020_03_27_012757 226 20 467 467 CD 10_1101-2020_03_27_012757 226 21 genes gene NNS 10_1101-2020_03_27_012757 226 22 in in IN 10_1101-2020_03_27_012757 226 23 the the DT 10_1101-2020_03_27_012757 226 24 genome genome NN 10_1101-2020_03_27_012757 226 25 , , , 10_1101-2020_03_27_012757 226 26 it -PRON- PRP 10_1101-2020_03_27_012757 226 27 is be VBZ 10_1101-2020_03_27_012757 226 28 possible possible JJ 10_1101-2020_03_27_012757 226 29 that that IN 10_1101-2020_03_27_012757 226 30 a a DT 10_1101-2020_03_27_012757 226 31 cancer cancer NN 10_1101-2020_03_27_012757 226 32 model model NN 10_1101-2020_03_27_012757 226 33 with with IN 10_1101-2020_03_27_012757 226 34 a a DT 10_1101-2020_03_27_012757 226 35 high high JJ 10_1101-2020_03_27_012757 226 36 CCN CCN NNP 10_1101-2020_03_27_012757 226 37 score score NN 10_1101-2020_03_27_012757 226 38 might may MD 10_1101-2020_03_27_012757 226 39 not not RB 10_1101-2020_03_27_012757 226 40 have have VB 10_1101-2020_03_27_012757 226 41 a a DT 10_1101-2020_03_27_012757 226 42 468 468 CD 10_1101-2020_03_27_012757 226 43 high high JJ 10_1101-2020_03_27_012757 226 44 global global JJ 10_1101-2020_03_27_012757 226 45 similarity similarity NN 10_1101-2020_03_27_012757 226 46 to to IN 10_1101-2020_03_27_012757 226 47 a a DT 10_1101-2020_03_27_012757 226 48 naturally naturally RB 10_1101-2020_03_27_012757 226 49 occurring occur VBG 10_1101-2020_03_27_012757 226 50 tumor tumor NN 10_1101-2020_03_27_012757 226 51 . . . 10_1101-2020_03_27_012757 227 1 Therefore therefore RB 10_1101-2020_03_27_012757 227 2 , , , 10_1101-2020_03_27_012757 227 3 we -PRON- PRP 10_1101-2020_03_27_012757 227 4 also also RB 10_1101-2020_03_27_012757 227 5 calculated calculate VBD 10_1101-2020_03_27_012757 227 6 the the DT 10_1101-2020_03_27_012757 227 7 GRN GRN NNP 10_1101-2020_03_27_012757 227 8 469 469 CD 10_1101-2020_03_27_012757 227 9 status status NN 10_1101-2020_03_27_012757 227 10 , , , 10_1101-2020_03_27_012757 227 11 a a DT 10_1101-2020_03_27_012757 227 12 metric metric NN 10_1101-2020_03_27_012757 227 13 of of IN 10_1101-2020_03_27_012757 227 14 the the DT 10_1101-2020_03_27_012757 227 15 extent extent NN 10_1101-2020_03_27_012757 227 16 to to TO 10_1101-2020_03_27_012757 227 17 which which WDT 10_1101-2020_03_27_012757 227 18 tumor tumor NN 10_1101-2020_03_27_012757 227 19 - - HYPH 10_1101-2020_03_27_012757 227 20 type type NN 10_1101-2020_03_27_012757 227 21 specific specific JJ 10_1101-2020_03_27_012757 227 22 gene gene NN 10_1101-2020_03_27_012757 227 23 regulatory regulatory JJ 10_1101-2020_03_27_012757 227 24 network network NN 10_1101-2020_03_27_012757 227 25 is be VBZ 10_1101-2020_03_27_012757 227 26 470 470 CD 10_1101-2020_03_27_012757 227 27 established21 established21 NNS 10_1101-2020_03_27_012757 227 28 , , , 10_1101-2020_03_27_012757 227 29 for for IN 10_1101-2020_03_27_012757 227 30 all all DT 10_1101-2020_03_27_012757 227 31 models model NNS 10_1101-2020_03_27_012757 227 32 ( ( -LRB- 10_1101-2020_03_27_012757 227 33 Supp Supp NNP 10_1101-2020_03_27_012757 227 34 Fig Fig NNP 10_1101-2020_03_27_012757 227 35 4 4 CD 10_1101-2020_03_27_012757 227 36 ) ) -RRB- 10_1101-2020_03_27_012757 227 37 . . . 10_1101-2020_03_27_012757 228 1 We -PRON- PRP 10_1101-2020_03_27_012757 228 2 observed observe VBD 10_1101-2020_03_27_012757 228 3 high high JJ 10_1101-2020_03_27_012757 228 4 level level NN 10_1101-2020_03_27_012757 228 5 of of IN 10_1101-2020_03_27_012757 228 6 correlation correlation NN 10_1101-2020_03_27_012757 228 7 between between IN 10_1101-2020_03_27_012757 228 8 the the DT 10_1101-2020_03_27_012757 228 9 471 471 CD 10_1101-2020_03_27_012757 228 10 two two CD 10_1101-2020_03_27_012757 228 11 similarity similarity NN 10_1101-2020_03_27_012757 228 12 metrics metric NNS 10_1101-2020_03_27_012757 228 13 , , , 10_1101-2020_03_27_012757 228 14 which which WDT 10_1101-2020_03_27_012757 228 15 suggests suggest VBZ 10_1101-2020_03_27_012757 228 16 that that IN 10_1101-2020_03_27_012757 228 17 although although IN 10_1101-2020_03_27_012757 228 18 CCN CCN NNP 10_1101-2020_03_27_012757 228 19 classifies classifie NNS 10_1101-2020_03_27_012757 228 20 on on IN 10_1101-2020_03_27_012757 228 21 a a DT 10_1101-2020_03_27_012757 228 22 selected select VBN 10_1101-2020_03_27_012757 228 23 set set NN 10_1101-2020_03_27_012757 228 24 of of IN 10_1101-2020_03_27_012757 228 25 genes gene NNS 10_1101-2020_03_27_012757 228 26 , , , 10_1101-2020_03_27_012757 228 27 472 472 CD 10_1101-2020_03_27_012757 228 28 its -PRON- PRP$ 10_1101-2020_03_27_012757 228 29 scores score NNS 10_1101-2020_03_27_012757 228 30 are be VBP 10_1101-2020_03_27_012757 228 31 highly highly RB 10_1101-2020_03_27_012757 228 32 correlated correlate VBN 10_1101-2020_03_27_012757 228 33 with with IN 10_1101-2020_03_27_012757 228 34 global global JJ 10_1101-2020_03_27_012757 228 35 assessment assessment NN 10_1101-2020_03_27_012757 228 36 of of IN 10_1101-2020_03_27_012757 228 37 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 228 38 similarity similarity NN 10_1101-2020_03_27_012757 228 39 . . . 10_1101-2020_03_27_012757 229 1 473 473 CD 10_1101-2020_03_27_012757 229 2 .CC .CC : 10_1101-2020_03_27_012757 229 3 - - HYPH 10_1101-2020_03_27_012757 229 4 BY by IN 10_1101-2020_03_27_012757 229 5 - - HYPH 10_1101-2020_03_27_012757 229 6 NC NC NNP 10_1101-2020_03_27_012757 229 7 - - HYPH 10_1101-2020_03_27_012757 229 8 ND ND NNP 10_1101-2020_03_27_012757 229 9 4.0 4.0 CD 10_1101-2020_03_27_012757 229 10 International International NNP 10_1101-2020_03_27_012757 229 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 229 12 under under IN 10_1101-2020_03_27_012757 229 13 a a DT 10_1101-2020_03_27_012757 229 14 ( ( -LRB- 10_1101-2020_03_27_012757 229 15 which which WDT 10_1101-2020_03_27_012757 229 16 was be VBD 10_1101-2020_03_27_012757 229 17 not not RB 10_1101-2020_03_27_012757 229 18 certified certify VBN 10_1101-2020_03_27_012757 229 19 by by IN 10_1101-2020_03_27_012757 229 20 peer peer NN 10_1101-2020_03_27_012757 229 21 review review NN 10_1101-2020_03_27_012757 229 22 ) ) -RRB- 10_1101-2020_03_27_012757 229 23 is be VBZ 10_1101-2020_03_27_012757 229 24 the the DT 10_1101-2020_03_27_012757 229 25 author author NN 10_1101-2020_03_27_012757 229 26 / / SYM 10_1101-2020_03_27_012757 229 27 funder funder NN 10_1101-2020_03_27_012757 229 28 , , , 10_1101-2020_03_27_012757 229 29 who who WP 10_1101-2020_03_27_012757 229 30 has have VBZ 10_1101-2020_03_27_012757 229 31 granted grant VBN 10_1101-2020_03_27_012757 229 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 229 33 a a DT 10_1101-2020_03_27_012757 229 34 license license NN 10_1101-2020_03_27_012757 229 35 to to TO 10_1101-2020_03_27_012757 229 36 display display VB 10_1101-2020_03_27_012757 229 37 the the DT 10_1101-2020_03_27_012757 229 38 preprint preprint NN 10_1101-2020_03_27_012757 229 39 in in IN 10_1101-2020_03_27_012757 229 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 229 41 . . . 10_1101-2020_03_27_012757 230 1 It -PRON- PRP 10_1101-2020_03_27_012757 230 2 is be VBZ 10_1101-2020_03_27_012757 230 3 made make VBN 10_1101-2020_03_27_012757 230 4 The the DT 10_1101-2020_03_27_012757 230 5 copyright copyright NN 10_1101-2020_03_27_012757 230 6 holder holder NN 10_1101-2020_03_27_012757 230 7 for for IN 10_1101-2020_03_27_012757 230 8 this this DT 10_1101-2020_03_27_012757 230 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 230 10 version version NN 10_1101-2020_03_27_012757 230 11 posted post VBD 10_1101-2020_03_27_012757 230 12 January January NNP 10_1101-2020_03_27_012757 230 13 9 9 CD 10_1101-2020_03_27_012757 230 14 , , , 10_1101-2020_03_27_012757 230 15 2021 2021 CD 10_1101-2020_03_27_012757 230 16 . . . 10_1101-2020_03_27_012757 230 17 ; ; : 10_1101-2020_03_27_012757 230 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 230 19 : : : 10_1101-2020_03_27_012757 230 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 230 21 preprint preprint NN 10_1101-2020_03_27_012757 230 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 230 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 230 24 18 18 CD 10_1101-2020_03_27_012757 230 25 We -PRON- PRP 10_1101-2020_03_27_012757 230 26 also also RB 10_1101-2020_03_27_012757 230 27 sought seek VBD 10_1101-2020_03_27_012757 230 28 to to TO 10_1101-2020_03_27_012757 230 29 compare compare VB 10_1101-2020_03_27_012757 230 30 model model NN 10_1101-2020_03_27_012757 230 31 modalities modality NNS 10_1101-2020_03_27_012757 230 32 in in IN 10_1101-2020_03_27_012757 230 33 terms term NNS 10_1101-2020_03_27_012757 230 34 of of IN 10_1101-2020_03_27_012757 230 35 the the DT 10_1101-2020_03_27_012757 230 36 diversity diversity NN 10_1101-2020_03_27_012757 230 37 of of IN 10_1101-2020_03_27_012757 230 38 subtypes subtype NNS 10_1101-2020_03_27_012757 230 39 that that IN 10_1101-2020_03_27_012757 230 40 474 474 CD 10_1101-2020_03_27_012757 230 41 they -PRON- PRP 10_1101-2020_03_27_012757 230 42 represent represent VBP 10_1101-2020_03_27_012757 230 43 ( ( -LRB- 10_1101-2020_03_27_012757 230 44 Supp Supp NNP 10_1101-2020_03_27_012757 230 45 Fig Fig NNP 10_1101-2020_03_27_012757 230 46 5 5 CD 10_1101-2020_03_27_012757 230 47 ) ) -RRB- 10_1101-2020_03_27_012757 230 48 . . . 10_1101-2020_03_27_012757 231 1 As as IN 10_1101-2020_03_27_012757 231 2 a a DT 10_1101-2020_03_27_012757 231 3 reference reference NN 10_1101-2020_03_27_012757 231 4 , , , 10_1101-2020_03_27_012757 231 5 we -PRON- PRP 10_1101-2020_03_27_012757 231 6 also also RB 10_1101-2020_03_27_012757 231 7 included include VBD 10_1101-2020_03_27_012757 231 8 in in IN 10_1101-2020_03_27_012757 231 9 this this DT 10_1101-2020_03_27_012757 231 10 analysis analysis NN 10_1101-2020_03_27_012757 231 11 the the DT 10_1101-2020_03_27_012757 231 12 overall overall JJ 10_1101-2020_03_27_012757 231 13 475 475 CD 10_1101-2020_03_27_012757 231 14 subtype subtype NN 10_1101-2020_03_27_012757 231 15 incidence incidence NN 10_1101-2020_03_27_012757 231 16 , , , 10_1101-2020_03_27_012757 231 17 as as IN 10_1101-2020_03_27_012757 231 18 approximated approximate VBN 10_1101-2020_03_27_012757 231 19 by by IN 10_1101-2020_03_27_012757 231 20 incidence incidence NN 10_1101-2020_03_27_012757 231 21 in in IN 10_1101-2020_03_27_012757 231 22 TCGA TCGA NNP 10_1101-2020_03_27_012757 231 23 . . . 10_1101-2020_03_27_012757 232 1 Replicates replicate NNS 10_1101-2020_03_27_012757 232 2 in in IN 10_1101-2020_03_27_012757 232 3 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 232 4 and and CC 10_1101-2020_03_27_012757 232 5 476 476 CD 10_1101-2020_03_27_012757 232 6 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 232 7 were be VBD 10_1101-2020_03_27_012757 232 8 averaged average VBN 10_1101-2020_03_27_012757 232 9 into into IN 10_1101-2020_03_27_012757 232 10 one one CD 10_1101-2020_03_27_012757 232 11 classification classification NN 10_1101-2020_03_27_012757 232 12 profile profile NN 10_1101-2020_03_27_012757 232 13 . . . 10_1101-2020_03_27_012757 233 1 In in IN 10_1101-2020_03_27_012757 233 2 models model NNS 10_1101-2020_03_27_012757 233 3 of of IN 10_1101-2020_03_27_012757 233 4 UCEC UCEC NNP 10_1101-2020_03_27_012757 233 5 , , , 10_1101-2020_03_27_012757 233 6 there there EX 10_1101-2020_03_27_012757 233 7 is be VBZ 10_1101-2020_03_27_012757 233 8 a a DT 10_1101-2020_03_27_012757 233 9 notable notable JJ 10_1101-2020_03_27_012757 233 10 477 477 CD 10_1101-2020_03_27_012757 233 11 difference difference NN 10_1101-2020_03_27_012757 233 12 in in IN 10_1101-2020_03_27_012757 233 13 endometroid endometroid JJ 10_1101-2020_03_27_012757 233 14 incidence incidence NN 10_1101-2020_03_27_012757 233 15 , , , 10_1101-2020_03_27_012757 233 16 and and CC 10_1101-2020_03_27_012757 233 17 the the DT 10_1101-2020_03_27_012757 233 18 proportion proportion NN 10_1101-2020_03_27_012757 233 19 of of IN 10_1101-2020_03_27_012757 233 20 models model NNS 10_1101-2020_03_27_012757 233 21 classified classify VBN 10_1101-2020_03_27_012757 233 22 as as IN 10_1101-2020_03_27_012757 233 23 endometroid endometroid NNP 10_1101-2020_03_27_012757 233 24 , , , 10_1101-2020_03_27_012757 233 25 478 478 CD 10_1101-2020_03_27_012757 233 26 with with IN 10_1101-2020_03_27_012757 233 27 PDX PDX NNP 10_1101-2020_03_27_012757 233 28 and and CC 10_1101-2020_03_27_012757 233 29 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 233 30 having have VBG 10_1101-2020_03_27_012757 233 31 any any DT 10_1101-2020_03_27_012757 233 32 representatives representative NNS 10_1101-2020_03_27_012757 233 33 ( ( -LRB- 10_1101-2020_03_27_012757 233 34 Supp Supp NNP 10_1101-2020_03_27_012757 233 35 Fig Fig NNP 10_1101-2020_03_27_012757 233 36 5 5 CD 10_1101-2020_03_27_012757 233 37 ) ) -RRB- 10_1101-2020_03_27_012757 233 38 . . . 10_1101-2020_03_27_012757 234 1 All all DT 10_1101-2020_03_27_012757 234 2 of of IN 10_1101-2020_03_27_012757 234 3 the the DT 10_1101-2020_03_27_012757 234 4 CCL CCL NNP 10_1101-2020_03_27_012757 234 5 , , , 10_1101-2020_03_27_012757 234 6 GEMM GEMM NNP 10_1101-2020_03_27_012757 234 7 , , , 10_1101-2020_03_27_012757 234 8 and and CC 10_1101-2020_03_27_012757 234 9 479 479 CD 10_1101-2020_03_27_012757 234 10 tumoroid tumoroid NN 10_1101-2020_03_27_012757 234 11 models model NNS 10_1101-2020_03_27_012757 234 12 of of IN 10_1101-2020_03_27_012757 234 13 PAAD PAAD NNP 10_1101-2020_03_27_012757 234 14 have have VBP 10_1101-2020_03_27_012757 234 15 an an DT 10_1101-2020_03_27_012757 234 16 unknown unknown JJ 10_1101-2020_03_27_012757 234 17 subtype subtype NN 10_1101-2020_03_27_012757 234 18 classification classification NN 10_1101-2020_03_27_012757 234 19 and and CC 10_1101-2020_03_27_012757 234 20 no no DT 10_1101-2020_03_27_012757 234 21 correct correct JJ 10_1101-2020_03_27_012757 234 22 general general JJ 10_1101-2020_03_27_012757 234 23 480 480 CD 10_1101-2020_03_27_012757 234 24 classification classification NN 10_1101-2020_03_27_012757 234 25 . . . 10_1101-2020_03_27_012757 235 1 However however RB 10_1101-2020_03_27_012757 235 2 , , , 10_1101-2020_03_27_012757 235 3 the the DT 10_1101-2020_03_27_012757 235 4 majority majority NN 10_1101-2020_03_27_012757 235 5 of of IN 10_1101-2020_03_27_012757 235 6 PDXs pdx NNS 10_1101-2020_03_27_012757 235 7 are be VBP 10_1101-2020_03_27_012757 235 8 subtyped subtyped JJ 10_1101-2020_03_27_012757 235 9 as as IN 10_1101-2020_03_27_012757 235 10 either either CC 10_1101-2020_03_27_012757 235 11 a a DT 10_1101-2020_03_27_012757 235 12 mixture mixture NN 10_1101-2020_03_27_012757 235 13 of of IN 10_1101-2020_03_27_012757 235 14 basal basal NN 10_1101-2020_03_27_012757 235 15 and and CC 10_1101-2020_03_27_012757 235 16 481 481 CD 10_1101-2020_03_27_012757 235 17 classical classical JJ 10_1101-2020_03_27_012757 235 18 , , , 10_1101-2020_03_27_012757 235 19 or or CC 10_1101-2020_03_27_012757 235 20 classical classical JJ 10_1101-2020_03_27_012757 235 21 alone alone RB 10_1101-2020_03_27_012757 235 22 . . . 10_1101-2020_03_27_012757 236 1 LUAD luad RB 10_1101-2020_03_27_012757 236 2 have have VBP 10_1101-2020_03_27_012757 236 3 proximal proximal JJ 10_1101-2020_03_27_012757 236 4 inflammation inflammation NN 10_1101-2020_03_27_012757 236 5 and and CC 10_1101-2020_03_27_012757 236 6 proximal proximal JJ 10_1101-2020_03_27_012757 236 7 proliferation proliferation NN 10_1101-2020_03_27_012757 236 8 482 482 CD 10_1101-2020_03_27_012757 236 9 subtypes subtype NNS 10_1101-2020_03_27_012757 236 10 modelled model VBN 10_1101-2020_03_27_012757 236 11 by by IN 10_1101-2020_03_27_012757 236 12 CCLs ccl NNS 10_1101-2020_03_27_012757 236 13 and and CC 10_1101-2020_03_27_012757 236 14 PDX PDX NNP 10_1101-2020_03_27_012757 236 15 ( ( -LRB- 10_1101-2020_03_27_012757 236 16 Supp Supp NNP 10_1101-2020_03_27_012757 236 17 Fig Fig NNP 10_1101-2020_03_27_012757 236 18 5 5 CD 10_1101-2020_03_27_012757 236 19 ) ) -RRB- 10_1101-2020_03_27_012757 236 20 . . . 10_1101-2020_03_27_012757 237 1 Likewise likewise RB 10_1101-2020_03_27_012757 237 2 , , , 10_1101-2020_03_27_012757 237 3 LUSC LUSC NNP 10_1101-2020_03_27_012757 237 4 have have VBP 10_1101-2020_03_27_012757 237 5 basal basal NN 10_1101-2020_03_27_012757 237 6 , , , 10_1101-2020_03_27_012757 237 7 classical classical JJ 10_1101-2020_03_27_012757 237 8 and and CC 10_1101-2020_03_27_012757 237 9 483 483 CD 10_1101-2020_03_27_012757 237 10 primitive primitive JJ 10_1101-2020_03_27_012757 237 11 subtypes subtype NNS 10_1101-2020_03_27_012757 237 12 modelled model VBN 10_1101-2020_03_27_012757 237 13 by by IN 10_1101-2020_03_27_012757 237 14 CCLs ccl NNS 10_1101-2020_03_27_012757 237 15 and and CC 10_1101-2020_03_27_012757 237 16 PDXs pdx NNS 10_1101-2020_03_27_012757 237 17 , , , 10_1101-2020_03_27_012757 237 18 and and CC 10_1101-2020_03_27_012757 237 19 secretory secretory JJ 10_1101-2020_03_27_012757 237 20 subtype subtype NN 10_1101-2020_03_27_012757 237 21 modelled model VBN 10_1101-2020_03_27_012757 237 22 by by IN 10_1101-2020_03_27_012757 237 23 GEMMs gemm NNS 10_1101-2020_03_27_012757 237 24 484 484 CD 10_1101-2020_03_27_012757 237 25 exclusively exclusively RB 10_1101-2020_03_27_012757 237 26 ( ( -LRB- 10_1101-2020_03_27_012757 237 27 Supp Supp NNP 10_1101-2020_03_27_012757 237 28 Fig Fig NNP 10_1101-2020_03_27_012757 237 29 5 5 CD 10_1101-2020_03_27_012757 237 30 ) ) -RRB- 10_1101-2020_03_27_012757 237 31 . . . 10_1101-2020_03_27_012757 238 1 Taken take VBN 10_1101-2020_03_27_012757 238 2 together together RB 10_1101-2020_03_27_012757 238 3 , , , 10_1101-2020_03_27_012757 238 4 these these DT 10_1101-2020_03_27_012757 238 5 results result NNS 10_1101-2020_03_27_012757 238 6 demonstrate demonstrate VBP 10_1101-2020_03_27_012757 238 7 the the DT 10_1101-2020_03_27_012757 238 8 need need NN 10_1101-2020_03_27_012757 238 9 to to TO 10_1101-2020_03_27_012757 238 10 carefully carefully RB 10_1101-2020_03_27_012757 238 11 select select VB 10_1101-2020_03_27_012757 238 12 485 485 CD 10_1101-2020_03_27_012757 238 13 different different JJ 10_1101-2020_03_27_012757 238 14 model model NN 10_1101-2020_03_27_012757 238 15 systems system NNS 10_1101-2020_03_27_012757 238 16 to to IN 10_1101-2020_03_27_012757 238 17 more more RBR 10_1101-2020_03_27_012757 238 18 suitably suitably RB 10_1101-2020_03_27_012757 238 19 model model NN 10_1101-2020_03_27_012757 238 20 certain certain JJ 10_1101-2020_03_27_012757 238 21 cancer cancer NN 10_1101-2020_03_27_012757 238 22 subtypes subtype NNS 10_1101-2020_03_27_012757 238 23 . . . 10_1101-2020_03_27_012757 239 1 486 486 CD 10_1101-2020_03_27_012757 239 2 487 487 CD 10_1101-2020_03_27_012757 239 3 DISCUSSION discussion NN 10_1101-2020_03_27_012757 239 4 488 488 CD 10_1101-2020_03_27_012757 239 5 A a DT 10_1101-2020_03_27_012757 239 6 major major JJ 10_1101-2020_03_27_012757 239 7 goal goal NN 10_1101-2020_03_27_012757 239 8 in in IN 10_1101-2020_03_27_012757 239 9 the the DT 10_1101-2020_03_27_012757 239 10 field field NN 10_1101-2020_03_27_012757 239 11 of of IN 10_1101-2020_03_27_012757 239 12 cancer cancer NN 10_1101-2020_03_27_012757 239 13 biology biology NN 10_1101-2020_03_27_012757 239 14 is be VBZ 10_1101-2020_03_27_012757 239 15 to to TO 10_1101-2020_03_27_012757 239 16 develop develop VB 10_1101-2020_03_27_012757 239 17 models model NNS 10_1101-2020_03_27_012757 239 18 that that WDT 10_1101-2020_03_27_012757 239 19 mimic mimic VBP 10_1101-2020_03_27_012757 239 20 naturally naturally RB 10_1101-2020_03_27_012757 239 21 occurring occur VBG 10_1101-2020_03_27_012757 239 22 489 489 CD 10_1101-2020_03_27_012757 239 23 tumors tumor NNS 10_1101-2020_03_27_012757 239 24 with with IN 10_1101-2020_03_27_012757 239 25 enough enough JJ 10_1101-2020_03_27_012757 239 26 fidelity fidelity NN 10_1101-2020_03_27_012757 239 27 to to TO 10_1101-2020_03_27_012757 239 28 enable enable VB 10_1101-2020_03_27_012757 239 29 therapeutic therapeutic JJ 10_1101-2020_03_27_012757 239 30 discoveries discovery NNS 10_1101-2020_03_27_012757 239 31 . . . 10_1101-2020_03_27_012757 240 1 However however RB 10_1101-2020_03_27_012757 240 2 , , , 10_1101-2020_03_27_012757 240 3 methods method NNS 10_1101-2020_03_27_012757 240 4 to to TO 10_1101-2020_03_27_012757 240 5 measure measure VB 10_1101-2020_03_27_012757 240 6 490 490 CD 10_1101-2020_03_27_012757 240 7 the the DT 10_1101-2020_03_27_012757 240 8 extent extent NN 10_1101-2020_03_27_012757 240 9 to to TO 10_1101-2020_03_27_012757 240 10 which which WDT 10_1101-2020_03_27_012757 240 11 cancer cancer NN 10_1101-2020_03_27_012757 240 12 models model NNS 10_1101-2020_03_27_012757 240 13 resemble resemble VBP 10_1101-2020_03_27_012757 240 14 or or CC 10_1101-2020_03_27_012757 240 15 diverge diverge VBP 10_1101-2020_03_27_012757 240 16 from from IN 10_1101-2020_03_27_012757 240 17 native native JJ 10_1101-2020_03_27_012757 240 18 tumors tumor NNS 10_1101-2020_03_27_012757 240 19 are be VBP 10_1101-2020_03_27_012757 240 20 lacking lack VBG 10_1101-2020_03_27_012757 240 21 . . . 10_1101-2020_03_27_012757 241 1 This this DT 10_1101-2020_03_27_012757 241 2 is be VBZ 10_1101-2020_03_27_012757 241 3 491 491 CD 10_1101-2020_03_27_012757 241 4 especially especially RB 10_1101-2020_03_27_012757 241 5 problematic problematic JJ 10_1101-2020_03_27_012757 241 6 now now RB 10_1101-2020_03_27_012757 241 7 because because IN 10_1101-2020_03_27_012757 241 8 there there EX 10_1101-2020_03_27_012757 241 9 are be VBP 10_1101-2020_03_27_012757 241 10 many many JJ 10_1101-2020_03_27_012757 241 11 existing exist VBG 10_1101-2020_03_27_012757 241 12 models model NNS 10_1101-2020_03_27_012757 241 13 from from IN 10_1101-2020_03_27_012757 241 14 which which WDT 10_1101-2020_03_27_012757 241 15 to to TO 10_1101-2020_03_27_012757 241 16 choose choose VB 10_1101-2020_03_27_012757 241 17 , , , 10_1101-2020_03_27_012757 241 18 and and CC 10_1101-2020_03_27_012757 241 19 492 492 CD 10_1101-2020_03_27_012757 241 20 it -PRON- PRP 10_1101-2020_03_27_012757 241 21 has have VBZ 10_1101-2020_03_27_012757 241 22 become become VBN 10_1101-2020_03_27_012757 241 23 easier easy JJR 10_1101-2020_03_27_012757 241 24 to to TO 10_1101-2020_03_27_012757 241 25 generate generate VB 10_1101-2020_03_27_012757 241 26 new new JJ 10_1101-2020_03_27_012757 241 27 models model NNS 10_1101-2020_03_27_012757 241 28 . . . 10_1101-2020_03_27_012757 242 1 Here here RB 10_1101-2020_03_27_012757 242 2 , , , 10_1101-2020_03_27_012757 242 3 we -PRON- PRP 10_1101-2020_03_27_012757 242 4 present present VBP 10_1101-2020_03_27_012757 242 5 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 242 6 ( ( -LRB- 10_1101-2020_03_27_012757 242 7 CCN CCN NNP 10_1101-2020_03_27_012757 242 8 ) ) -RRB- 10_1101-2020_03_27_012757 242 9 , , , 10_1101-2020_03_27_012757 242 10 a a DT 10_1101-2020_03_27_012757 242 11 493 493 CD 10_1101-2020_03_27_012757 242 12 computational computational JJ 10_1101-2020_03_27_012757 242 13 tool tool NN 10_1101-2020_03_27_012757 242 14 that that WDT 10_1101-2020_03_27_012757 242 15 measures measure VBZ 10_1101-2020_03_27_012757 242 16 the the DT 10_1101-2020_03_27_012757 242 17 similarity similarity NN 10_1101-2020_03_27_012757 242 18 of of IN 10_1101-2020_03_27_012757 242 19 cancer cancer NN 10_1101-2020_03_27_012757 242 20 models model NNS 10_1101-2020_03_27_012757 242 21 to to IN 10_1101-2020_03_27_012757 242 22 22 22 CD 10_1101-2020_03_27_012757 242 23 naturally naturally RB 10_1101-2020_03_27_012757 242 24 occurring occur VBG 10_1101-2020_03_27_012757 242 25 tumor tumor NN 10_1101-2020_03_27_012757 242 26 494 494 CD 10_1101-2020_03_27_012757 242 27 types type NNS 10_1101-2020_03_27_012757 242 28 and and CC 10_1101-2020_03_27_012757 242 29 36 36 CD 10_1101-2020_03_27_012757 242 30 subtypes subtype NNS 10_1101-2020_03_27_012757 242 31 . . . 10_1101-2020_03_27_012757 243 1 While while IN 10_1101-2020_03_27_012757 243 2 the the DT 10_1101-2020_03_27_012757 243 3 similarity similarity NN 10_1101-2020_03_27_012757 243 4 of of IN 10_1101-2020_03_27_012757 243 5 CCLs CCLs NNPS 10_1101-2020_03_27_012757 243 6 to to TO 10_1101-2020_03_27_012757 243 7 patient patient VB 10_1101-2020_03_27_012757 243 8 tumors tumor NNS 10_1101-2020_03_27_012757 243 9 has have VBZ 10_1101-2020_03_27_012757 243 10 already already RB 10_1101-2020_03_27_012757 243 11 been be VBN 10_1101-2020_03_27_012757 243 12 495 495 CD 10_1101-2020_03_27_012757 243 13 explored explore VBN 10_1101-2020_03_27_012757 243 14 in in IN 10_1101-2020_03_27_012757 243 15 previous previous JJ 10_1101-2020_03_27_012757 243 16 work work NN 10_1101-2020_03_27_012757 243 17 , , , 10_1101-2020_03_27_012757 243 18 our -PRON- PRP$ 10_1101-2020_03_27_012757 243 19 tool tool NN 10_1101-2020_03_27_012757 243 20 introduces introduce VBZ 10_1101-2020_03_27_012757 243 21 the the DT 10_1101-2020_03_27_012757 243 22 capability capability NN 10_1101-2020_03_27_012757 243 23 to to TO 10_1101-2020_03_27_012757 243 24 assess assess VB 10_1101-2020_03_27_012757 243 25 the the DT 10_1101-2020_03_27_012757 243 26 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 243 27 fidelity fidelity NNP 10_1101-2020_03_27_012757 243 28 496 496 CD 10_1101-2020_03_27_012757 243 29 of of IN 10_1101-2020_03_27_012757 243 30 PDXs pdx NNS 10_1101-2020_03_27_012757 243 31 , , , 10_1101-2020_03_27_012757 243 32 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 243 33 , , , 10_1101-2020_03_27_012757 243 34 and and CC 10_1101-2020_03_27_012757 243 35 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 243 36 . . . 10_1101-2020_03_27_012757 244 1 Because because IN 10_1101-2020_03_27_012757 244 2 CCN CCN NNP 10_1101-2020_03_27_012757 244 3 is be VBZ 10_1101-2020_03_27_012757 244 4 platform- platform- NN 10_1101-2020_03_27_012757 244 5 and and CC 10_1101-2020_03_27_012757 244 6 species species NN 10_1101-2020_03_27_012757 244 7 - - HYPH 10_1101-2020_03_27_012757 244 8 agnostic agnostic RB 10_1101-2020_03_27_012757 244 9 , , , 10_1101-2020_03_27_012757 244 10 it -PRON- PRP 10_1101-2020_03_27_012757 244 11 497 497 CD 10_1101-2020_03_27_012757 244 12 represents represent VBZ 10_1101-2020_03_27_012757 244 13 a a DT 10_1101-2020_03_27_012757 244 14 consistent consistent JJ 10_1101-2020_03_27_012757 244 15 platform platform NN 10_1101-2020_03_27_012757 244 16 to to TO 10_1101-2020_03_27_012757 244 17 compare compare VB 10_1101-2020_03_27_012757 244 18 models model NNS 10_1101-2020_03_27_012757 244 19 across across IN 10_1101-2020_03_27_012757 244 20 modalities modality NNS 10_1101-2020_03_27_012757 244 21 including include VBG 10_1101-2020_03_27_012757 244 22 CCLs CCLs NNP 10_1101-2020_03_27_012757 244 23 , , , 10_1101-2020_03_27_012757 244 24 PDXs pdx NNS 10_1101-2020_03_27_012757 244 25 , , , 10_1101-2020_03_27_012757 244 26 498 498 CD 10_1101-2020_03_27_012757 244 27 GEMMs gemm NNS 10_1101-2020_03_27_012757 244 28 and and CC 10_1101-2020_03_27_012757 244 29 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 244 30 . . . 10_1101-2020_03_27_012757 245 1 Here here RB 10_1101-2020_03_27_012757 245 2 , , , 10_1101-2020_03_27_012757 245 3 we -PRON- PRP 10_1101-2020_03_27_012757 245 4 applied apply VBD 10_1101-2020_03_27_012757 245 5 CCN CCN NNP 10_1101-2020_03_27_012757 245 6 to to IN 10_1101-2020_03_27_012757 245 7 657 657 CD 10_1101-2020_03_27_012757 245 8 cancer cancer NN 10_1101-2020_03_27_012757 245 9 cell cell NN 10_1101-2020_03_27_012757 245 10 lines line NNS 10_1101-2020_03_27_012757 245 11 , , , 10_1101-2020_03_27_012757 245 12 415 415 CD 10_1101-2020_03_27_012757 245 13 patient patient NN 10_1101-2020_03_27_012757 245 14 derived derive VBD 10_1101-2020_03_27_012757 245 15 499 499 CD 10_1101-2020_03_27_012757 245 16 .CC .CC , 10_1101-2020_03_27_012757 245 17 - - : 10_1101-2020_03_27_012757 245 18 BY by IN 10_1101-2020_03_27_012757 245 19 - - HYPH 10_1101-2020_03_27_012757 245 20 NC NC NNP 10_1101-2020_03_27_012757 245 21 - - HYPH 10_1101-2020_03_27_012757 245 22 ND ND NNP 10_1101-2020_03_27_012757 245 23 4.0 4.0 CD 10_1101-2020_03_27_012757 245 24 International International NNP 10_1101-2020_03_27_012757 245 25 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 245 26 under under IN 10_1101-2020_03_27_012757 245 27 a a DT 10_1101-2020_03_27_012757 245 28 ( ( -LRB- 10_1101-2020_03_27_012757 245 29 which which WDT 10_1101-2020_03_27_012757 245 30 was be VBD 10_1101-2020_03_27_012757 245 31 not not RB 10_1101-2020_03_27_012757 245 32 certified certify VBN 10_1101-2020_03_27_012757 245 33 by by IN 10_1101-2020_03_27_012757 245 34 peer peer NN 10_1101-2020_03_27_012757 245 35 review review NN 10_1101-2020_03_27_012757 245 36 ) ) -RRB- 10_1101-2020_03_27_012757 245 37 is be VBZ 10_1101-2020_03_27_012757 245 38 the the DT 10_1101-2020_03_27_012757 245 39 author author NN 10_1101-2020_03_27_012757 245 40 / / SYM 10_1101-2020_03_27_012757 245 41 funder funder NN 10_1101-2020_03_27_012757 245 42 , , , 10_1101-2020_03_27_012757 245 43 who who WP 10_1101-2020_03_27_012757 245 44 has have VBZ 10_1101-2020_03_27_012757 245 45 granted grant VBN 10_1101-2020_03_27_012757 245 46 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 245 47 a a DT 10_1101-2020_03_27_012757 245 48 license license NN 10_1101-2020_03_27_012757 245 49 to to TO 10_1101-2020_03_27_012757 245 50 display display VB 10_1101-2020_03_27_012757 245 51 the the DT 10_1101-2020_03_27_012757 245 52 preprint preprint NN 10_1101-2020_03_27_012757 245 53 in in IN 10_1101-2020_03_27_012757 245 54 perpetuity perpetuity NN 10_1101-2020_03_27_012757 245 55 . . . 10_1101-2020_03_27_012757 246 1 It -PRON- PRP 10_1101-2020_03_27_012757 246 2 is be VBZ 10_1101-2020_03_27_012757 246 3 made make VBN 10_1101-2020_03_27_012757 246 4 The the DT 10_1101-2020_03_27_012757 246 5 copyright copyright NN 10_1101-2020_03_27_012757 246 6 holder holder NN 10_1101-2020_03_27_012757 246 7 for for IN 10_1101-2020_03_27_012757 246 8 this this DT 10_1101-2020_03_27_012757 246 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 246 10 version version NN 10_1101-2020_03_27_012757 246 11 posted post VBD 10_1101-2020_03_27_012757 246 12 January January NNP 10_1101-2020_03_27_012757 246 13 9 9 CD 10_1101-2020_03_27_012757 246 14 , , , 10_1101-2020_03_27_012757 246 15 2021 2021 CD 10_1101-2020_03_27_012757 246 16 . . . 10_1101-2020_03_27_012757 246 17 ; ; : 10_1101-2020_03_27_012757 246 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 246 19 : : : 10_1101-2020_03_27_012757 246 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 246 21 preprint preprint NN 10_1101-2020_03_27_012757 246 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 246 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 246 24 19 19 CD 10_1101-2020_03_27_012757 246 25 xenografts xenograft NNS 10_1101-2020_03_27_012757 246 26 , , , 10_1101-2020_03_27_012757 246 27 26 26 CD 10_1101-2020_03_27_012757 246 28 distinct distinct JJ 10_1101-2020_03_27_012757 246 29 genetically genetically RB 10_1101-2020_03_27_012757 246 30 engineered engineer VBN 10_1101-2020_03_27_012757 246 31 mouse mouse NN 10_1101-2020_03_27_012757 246 32 models model NNS 10_1101-2020_03_27_012757 246 33 and and CC 10_1101-2020_03_27_012757 246 34 131 131 CD 10_1101-2020_03_27_012757 246 35 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 246 36 . . . 10_1101-2020_03_27_012757 247 1 Several several JJ 10_1101-2020_03_27_012757 247 2 500 500 CD 10_1101-2020_03_27_012757 247 3 insights insight NNS 10_1101-2020_03_27_012757 247 4 emerged emerge VBD 10_1101-2020_03_27_012757 247 5 from from IN 10_1101-2020_03_27_012757 247 6 our -PRON- PRP$ 10_1101-2020_03_27_012757 247 7 computational computational JJ 10_1101-2020_03_27_012757 247 8 analyses analysis NNS 10_1101-2020_03_27_012757 247 9 that that WDT 10_1101-2020_03_27_012757 247 10 have have VBP 10_1101-2020_03_27_012757 247 11 implications implication NNS 10_1101-2020_03_27_012757 247 12 for for IN 10_1101-2020_03_27_012757 247 13 the the DT 10_1101-2020_03_27_012757 247 14 field field NN 10_1101-2020_03_27_012757 247 15 of of IN 10_1101-2020_03_27_012757 247 16 cancer cancer NN 10_1101-2020_03_27_012757 247 17 501 501 CD 10_1101-2020_03_27_012757 247 18 biology biology NN 10_1101-2020_03_27_012757 247 19 . . . 10_1101-2020_03_27_012757 248 1 502 502 CD 10_1101-2020_03_27_012757 248 2 First first RB 10_1101-2020_03_27_012757 248 3 , , , 10_1101-2020_03_27_012757 248 4 PDXs pdx NNS 10_1101-2020_03_27_012757 248 5 have have VBP 10_1101-2020_03_27_012757 248 6 the the DT 10_1101-2020_03_27_012757 248 7 greatest great JJS 10_1101-2020_03_27_012757 248 8 potential potential NN 10_1101-2020_03_27_012757 248 9 to to TO 10_1101-2020_03_27_012757 248 10 achieve achieve VB 10_1101-2020_03_27_012757 248 11 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 248 12 fidelity fidelity NN 10_1101-2020_03_27_012757 248 13 with with IN 10_1101-2020_03_27_012757 248 14 three three CD 10_1101-2020_03_27_012757 248 15 out out IN 10_1101-2020_03_27_012757 248 16 of of IN 10_1101-2020_03_27_012757 248 17 503 503 CD 10_1101-2020_03_27_012757 248 18 five five CD 10_1101-2020_03_27_012757 248 19 general general JJ 10_1101-2020_03_27_012757 248 20 tumor tumor NN 10_1101-2020_03_27_012757 248 21 types type NNS 10_1101-2020_03_27_012757 248 22 for for IN 10_1101-2020_03_27_012757 248 23 which which WDT 10_1101-2020_03_27_012757 248 24 data datum NNS 10_1101-2020_03_27_012757 248 25 from from IN 10_1101-2020_03_27_012757 248 26 all all DT 10_1101-2020_03_27_012757 248 27 modalities modality NNS 10_1101-2020_03_27_012757 248 28 was be VBD 10_1101-2020_03_27_012757 248 29 available available JJ 10_1101-2020_03_27_012757 248 30 , , , 10_1101-2020_03_27_012757 248 31 as as IN 10_1101-2020_03_27_012757 248 32 indicated indicate VBN 10_1101-2020_03_27_012757 248 33 by by IN 10_1101-2020_03_27_012757 248 34 the the DT 10_1101-2020_03_27_012757 248 35 504 504 CD 10_1101-2020_03_27_012757 248 36 high high JJ 10_1101-2020_03_27_012757 248 37 scores score NNS 10_1101-2020_03_27_012757 248 38 of of IN 10_1101-2020_03_27_012757 248 39 individual individual JJ 10_1101-2020_03_27_012757 248 40 PDXs pdx NNS 10_1101-2020_03_27_012757 248 41 . . . 10_1101-2020_03_27_012757 249 1 Notably notably RB 10_1101-2020_03_27_012757 249 2 PDXs pdx NNS 10_1101-2020_03_27_012757 249 3 are be VBP 10_1101-2020_03_27_012757 249 4 the the DT 10_1101-2020_03_27_012757 249 5 only only JJ 10_1101-2020_03_27_012757 249 6 modality modality NN 10_1101-2020_03_27_012757 249 7 with with IN 10_1101-2020_03_27_012757 249 8 samples sample NNS 10_1101-2020_03_27_012757 249 9 classified classify VBD 10_1101-2020_03_27_012757 249 10 as as IN 10_1101-2020_03_27_012757 249 11 505 505 CD 10_1101-2020_03_27_012757 249 12 PAAD PAAD NNS 10_1101-2020_03_27_012757 249 13 . . . 10_1101-2020_03_27_012757 250 1 At at IN 10_1101-2020_03_27_012757 250 2 the the DT 10_1101-2020_03_27_012757 250 3 same same JJ 10_1101-2020_03_27_012757 250 4 time time NN 10_1101-2020_03_27_012757 250 5 , , , 10_1101-2020_03_27_012757 250 6 the the DT 10_1101-2020_03_27_012757 250 7 median median JJ 10_1101-2020_03_27_012757 250 8 CCN CCN NNP 10_1101-2020_03_27_012757 250 9 scores score NNS 10_1101-2020_03_27_012757 250 10 of of IN 10_1101-2020_03_27_012757 250 11 PDXs pdx NNS 10_1101-2020_03_27_012757 250 12 were be VBD 10_1101-2020_03_27_012757 250 13 lower low JJR 10_1101-2020_03_27_012757 250 14 than than IN 10_1101-2020_03_27_012757 250 15 that that DT 10_1101-2020_03_27_012757 250 16 of of IN 10_1101-2020_03_27_012757 250 17 GEMMs gemm NNS 10_1101-2020_03_27_012757 250 18 and and CC 10_1101-2020_03_27_012757 250 19 506 506 CD 10_1101-2020_03_27_012757 250 20 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 250 21 in in IN 10_1101-2020_03_27_012757 250 22 the the DT 10_1101-2020_03_27_012757 250 23 other other JJ 10_1101-2020_03_27_012757 250 24 four four CD 10_1101-2020_03_27_012757 250 25 tumor tumor NN 10_1101-2020_03_27_012757 250 26 types type NNS 10_1101-2020_03_27_012757 250 27 . . . 10_1101-2020_03_27_012757 251 1 It -PRON- PRP 10_1101-2020_03_27_012757 251 2 is be VBZ 10_1101-2020_03_27_012757 251 3 unclear unclear JJ 10_1101-2020_03_27_012757 251 4 what what WP 10_1101-2020_03_27_012757 251 5 causes cause VBZ 10_1101-2020_03_27_012757 251 6 such such PDT 10_1101-2020_03_27_012757 251 7 a a DT 10_1101-2020_03_27_012757 251 8 wide wide JJ 10_1101-2020_03_27_012757 251 9 range range NN 10_1101-2020_03_27_012757 251 10 of of IN 10_1101-2020_03_27_012757 251 11 CCN CCN NNP 10_1101-2020_03_27_012757 251 12 507 507 CD 10_1101-2020_03_27_012757 251 13 scores score NNS 10_1101-2020_03_27_012757 251 14 within within IN 10_1101-2020_03_27_012757 251 15 PDXs pdx NNS 10_1101-2020_03_27_012757 251 16 . . . 10_1101-2020_03_27_012757 252 1 We -PRON- PRP 10_1101-2020_03_27_012757 252 2 suspect suspect VBP 10_1101-2020_03_27_012757 252 3 that that IN 10_1101-2020_03_27_012757 252 4 some some DT 10_1101-2020_03_27_012757 252 5 PDXs pdx NNS 10_1101-2020_03_27_012757 252 6 might may MD 10_1101-2020_03_27_012757 252 7 have have VB 10_1101-2020_03_27_012757 252 8 undergone undergo VBN 10_1101-2020_03_27_012757 252 9 selective selective JJ 10_1101-2020_03_27_012757 252 10 pressures pressure NNS 10_1101-2020_03_27_012757 252 11 in in IN 10_1101-2020_03_27_012757 252 12 508 508 CD 10_1101-2020_03_27_012757 252 13 the the DT 10_1101-2020_03_27_012757 252 14 host host NN 10_1101-2020_03_27_012757 252 15 that that WDT 10_1101-2020_03_27_012757 252 16 distort distort VBP 10_1101-2020_03_27_012757 252 17 the the DT 10_1101-2020_03_27_012757 252 18 progression progression NN 10_1101-2020_03_27_012757 252 19 of of IN 10_1101-2020_03_27_012757 252 20 genomic genomic JJ 10_1101-2020_03_27_012757 252 21 alterations alteration NNS 10_1101-2020_03_27_012757 252 22 away away RB 10_1101-2020_03_27_012757 252 23 from from IN 10_1101-2020_03_27_012757 252 24 what what WP 10_1101-2020_03_27_012757 252 25 is be VBZ 10_1101-2020_03_27_012757 252 26 observed observe VBN 10_1101-2020_03_27_012757 252 27 in in IN 10_1101-2020_03_27_012757 252 28 509 509 CD 10_1101-2020_03_27_012757 252 29 natural natural JJ 10_1101-2020_03_27_012757 252 30 tumor73 tumor73 NN 10_1101-2020_03_27_012757 252 31 . . . 10_1101-2020_03_27_012757 253 1 Future future JJ 10_1101-2020_03_27_012757 253 2 work work NN 10_1101-2020_03_27_012757 253 3 to to TO 10_1101-2020_03_27_012757 253 4 understand understand VB 10_1101-2020_03_27_012757 253 5 this this DT 10_1101-2020_03_27_012757 253 6 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 253 7 is be VBZ 10_1101-2020_03_27_012757 253 8 important important JJ 10_1101-2020_03_27_012757 253 9 so so IN 10_1101-2020_03_27_012757 253 10 as as IN 10_1101-2020_03_27_012757 253 11 to to TO 10_1101-2020_03_27_012757 253 12 yield yield VB 10_1101-2020_03_27_012757 253 13 510 510 CD 10_1101-2020_03_27_012757 253 14 consistently consistently RB 10_1101-2020_03_27_012757 253 15 high high JJ 10_1101-2020_03_27_012757 253 16 fidelity fidelity NN 10_1101-2020_03_27_012757 253 17 PDXs pdx NNS 10_1101-2020_03_27_012757 253 18 , , , 10_1101-2020_03_27_012757 253 19 and and CC 10_1101-2020_03_27_012757 253 20 to to TO 10_1101-2020_03_27_012757 253 21 identify identify VB 10_1101-2020_03_27_012757 253 22 intrinsic intrinsic NN 10_1101-2020_03_27_012757 253 23 and and CC 10_1101-2020_03_27_012757 253 24 host host NN 10_1101-2020_03_27_012757 253 25 - - HYPH 10_1101-2020_03_27_012757 253 26 specific specific JJ 10_1101-2020_03_27_012757 253 27 factors factor NNS 10_1101-2020_03_27_012757 253 28 that that WDT 10_1101-2020_03_27_012757 253 29 so so RB 10_1101-2020_03_27_012757 253 30 511 511 CD 10_1101-2020_03_27_012757 253 31 powerfully powerfully RB 10_1101-2020_03_27_012757 253 32 shape shape VBP 10_1101-2020_03_27_012757 253 33 the the DT 10_1101-2020_03_27_012757 253 34 PDX pdx NN 10_1101-2020_03_27_012757 253 35 transcriptome transcriptome DT 10_1101-2020_03_27_012757 253 36 . . . 10_1101-2020_03_27_012757 254 1 512 512 CD 10_1101-2020_03_27_012757 254 2 Second second JJ 10_1101-2020_03_27_012757 254 3 , , , 10_1101-2020_03_27_012757 254 4 in in IN 10_1101-2020_03_27_012757 254 5 general general JJ 10_1101-2020_03_27_012757 254 6 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 254 7 and and CC 10_1101-2020_03_27_012757 254 8 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 254 9 have have VBP 10_1101-2020_03_27_012757 254 10 higher high JJR 10_1101-2020_03_27_012757 254 11 median median JJ 10_1101-2020_03_27_012757 254 12 CCN CCN NNP 10_1101-2020_03_27_012757 254 13 scores score NNS 10_1101-2020_03_27_012757 254 14 than than IN 10_1101-2020_03_27_012757 254 15 those those DT 10_1101-2020_03_27_012757 254 16 513 513 CD 10_1101-2020_03_27_012757 254 17 of of IN 10_1101-2020_03_27_012757 254 18 PDXs pdx NNS 10_1101-2020_03_27_012757 254 19 and and CC 10_1101-2020_03_27_012757 254 20 CCLs ccl NNS 10_1101-2020_03_27_012757 254 21 . . . 10_1101-2020_03_27_012757 255 1 This this DT 10_1101-2020_03_27_012757 255 2 is be VBZ 10_1101-2020_03_27_012757 255 3 also also RB 10_1101-2020_03_27_012757 255 4 consistent consistent JJ 10_1101-2020_03_27_012757 255 5 with with IN 10_1101-2020_03_27_012757 255 6 that that DT 10_1101-2020_03_27_012757 255 7 fact fact NN 10_1101-2020_03_27_012757 255 8 that that IN 10_1101-2020_03_27_012757 255 9 GEMMs gemm NNS 10_1101-2020_03_27_012757 255 10 are be VBP 10_1101-2020_03_27_012757 255 11 typically typically RB 10_1101-2020_03_27_012757 255 12 derived derive VBN 10_1101-2020_03_27_012757 255 13 by by IN 10_1101-2020_03_27_012757 255 14 514 514 CD 10_1101-2020_03_27_012757 255 15 recapitulating recapitulate VBG 10_1101-2020_03_27_012757 255 16 well well RB 10_1101-2020_03_27_012757 255 17 - - HYPH 10_1101-2020_03_27_012757 255 18 defined define VBN 10_1101-2020_03_27_012757 255 19 driver driver NN 10_1101-2020_03_27_012757 255 20 mutations mutation NNS 10_1101-2020_03_27_012757 255 21 of of IN 10_1101-2020_03_27_012757 255 22 natural natural JJ 10_1101-2020_03_27_012757 255 23 tumors tumor NNS 10_1101-2020_03_27_012757 255 24 , , , 10_1101-2020_03_27_012757 255 25 and and CC 10_1101-2020_03_27_012757 255 26 thus thus RB 10_1101-2020_03_27_012757 255 27 this this DT 10_1101-2020_03_27_012757 255 28 observation observation NN 10_1101-2020_03_27_012757 255 29 515 515 CD 10_1101-2020_03_27_012757 255 30 corroborates corroborate NNS 10_1101-2020_03_27_012757 255 31 the the DT 10_1101-2020_03_27_012757 255 32 importance importance NN 10_1101-2020_03_27_012757 255 33 of of IN 10_1101-2020_03_27_012757 255 34 genetics genetic NNS 10_1101-2020_03_27_012757 255 35 in in IN 10_1101-2020_03_27_012757 255 36 the the DT 10_1101-2020_03_27_012757 255 37 etiology etiology NN 10_1101-2020_03_27_012757 255 38 of of IN 10_1101-2020_03_27_012757 255 39 cancer74 cancer74 NNP 10_1101-2020_03_27_012757 255 40 . . . 10_1101-2020_03_27_012757 256 1 Moreover moreover RB 10_1101-2020_03_27_012757 256 2 , , , 10_1101-2020_03_27_012757 256 3 in in IN 10_1101-2020_03_27_012757 256 4 contrast contrast NN 10_1101-2020_03_27_012757 256 5 to to IN 10_1101-2020_03_27_012757 256 6 516 516 CD 10_1101-2020_03_27_012757 256 7 most most JJS 10_1101-2020_03_27_012757 256 8 PDXs pdx NNS 10_1101-2020_03_27_012757 256 9 , , , 10_1101-2020_03_27_012757 256 10 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 256 11 are be VBP 10_1101-2020_03_27_012757 256 12 typically typically RB 10_1101-2020_03_27_012757 256 13 generated generate VBN 10_1101-2020_03_27_012757 256 14 in in IN 10_1101-2020_03_27_012757 256 15 immune immune JJ 10_1101-2020_03_27_012757 256 16 replete replete JJ 10_1101-2020_03_27_012757 256 17 hosts host NNS 10_1101-2020_03_27_012757 256 18 . . . 10_1101-2020_03_27_012757 257 1 Therefore therefore RB 10_1101-2020_03_27_012757 257 2 , , , 10_1101-2020_03_27_012757 257 3 the the DT 10_1101-2020_03_27_012757 257 4 higher high JJR 10_1101-2020_03_27_012757 257 5 517 517 CD 10_1101-2020_03_27_012757 257 6 overall overall JJ 10_1101-2020_03_27_012757 257 7 fidelity fidelity NN 10_1101-2020_03_27_012757 257 8 of of IN 10_1101-2020_03_27_012757 257 9 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 257 10 may may MD 10_1101-2020_03_27_012757 257 11 also also RB 10_1101-2020_03_27_012757 257 12 be be VB 10_1101-2020_03_27_012757 257 13 a a DT 10_1101-2020_03_27_012757 257 14 result result NN 10_1101-2020_03_27_012757 257 15 of of IN 10_1101-2020_03_27_012757 257 16 the the DT 10_1101-2020_03_27_012757 257 17 influence influence NN 10_1101-2020_03_27_012757 257 18 of of IN 10_1101-2020_03_27_012757 257 19 a a DT 10_1101-2020_03_27_012757 257 20 native native JJ 10_1101-2020_03_27_012757 257 21 immune immune JJ 10_1101-2020_03_27_012757 257 22 system system NN 10_1101-2020_03_27_012757 257 23 on on IN 10_1101-2020_03_27_012757 257 24 518 518 CD 10_1101-2020_03_27_012757 257 25 GEMM GEMM NNP 10_1101-2020_03_27_012757 257 26 tumors75 tumors75 VBD 10_1101-2020_03_27_012757 257 27 . . . 10_1101-2020_03_27_012757 258 1 The the DT 10_1101-2020_03_27_012757 258 2 high high JJ 10_1101-2020_03_27_012757 258 3 median median JJ 10_1101-2020_03_27_012757 258 4 CCN CCN NNP 10_1101-2020_03_27_012757 258 5 scores score NNS 10_1101-2020_03_27_012757 258 6 of of IN 10_1101-2020_03_27_012757 258 7 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 258 8 can can MD 10_1101-2020_03_27_012757 258 9 be be VB 10_1101-2020_03_27_012757 258 10 attributed attribute VBN 10_1101-2020_03_27_012757 258 11 to to IN 10_1101-2020_03_27_012757 258 12 several several JJ 10_1101-2020_03_27_012757 258 13 factors factor NNS 10_1101-2020_03_27_012757 258 14 519 519 CD 10_1101-2020_03_27_012757 258 15 including include VBG 10_1101-2020_03_27_012757 258 16 the the DT 10_1101-2020_03_27_012757 258 17 increased increase VBN 10_1101-2020_03_27_012757 258 18 mechanical mechanical JJ 10_1101-2020_03_27_012757 258 19 stimuli stimulus NNS 10_1101-2020_03_27_012757 258 20 and and CC 10_1101-2020_03_27_012757 258 21 cell cell NN 10_1101-2020_03_27_012757 258 22 - - HYPH 10_1101-2020_03_27_012757 258 23 cell cell NN 10_1101-2020_03_27_012757 258 24 interactions interaction NNS 10_1101-2020_03_27_012757 258 25 that that WDT 10_1101-2020_03_27_012757 258 26 come come VBP 10_1101-2020_03_27_012757 258 27 from from IN 10_1101-2020_03_27_012757 258 28 3D 3D NNP 10_1101-2020_03_27_012757 258 29 self-520 self-520 NNP 10_1101-2020_03_27_012757 258 30 organizing organize VBG 10_1101-2020_03_27_012757 258 31 cultures76,77 cultures76,77 NNP 10_1101-2020_03_27_012757 258 32 . . . 10_1101-2020_03_27_012757 259 1 521 521 CD 10_1101-2020_03_27_012757 259 2 Third third JJ 10_1101-2020_03_27_012757 259 3 , , , 10_1101-2020_03_27_012757 259 4 we -PRON- PRP 10_1101-2020_03_27_012757 259 5 have have VBP 10_1101-2020_03_27_012757 259 6 found find VBN 10_1101-2020_03_27_012757 259 7 that that IN 10_1101-2020_03_27_012757 259 8 none none NN 10_1101-2020_03_27_012757 259 9 of of IN 10_1101-2020_03_27_012757 259 10 the the DT 10_1101-2020_03_27_012757 259 11 samples sample NNS 10_1101-2020_03_27_012757 259 12 that that WDT 10_1101-2020_03_27_012757 259 13 we -PRON- PRP 10_1101-2020_03_27_012757 259 14 evaluated evaluate VBD 10_1101-2020_03_27_012757 259 15 here here RB 10_1101-2020_03_27_012757 259 16 are be VBP 10_1101-2020_03_27_012757 259 17 522 522 CD 10_1101-2020_03_27_012757 259 18 transcriptionally transcriptionally RB 10_1101-2020_03_27_012757 259 19 adequate adequate JJ 10_1101-2020_03_27_012757 259 20 models model NNS 10_1101-2020_03_27_012757 259 21 of of IN 10_1101-2020_03_27_012757 259 22 ESCA ESCA NNP 10_1101-2020_03_27_012757 259 23 . . . 10_1101-2020_03_27_012757 260 1 This this DT 10_1101-2020_03_27_012757 260 2 may may MD 10_1101-2020_03_27_012757 260 3 be be VB 10_1101-2020_03_27_012757 260 4 due due IN 10_1101-2020_03_27_012757 260 5 to to IN 10_1101-2020_03_27_012757 260 6 an an DT 10_1101-2020_03_27_012757 260 7 inherent inherent JJ 10_1101-2020_03_27_012757 260 8 lability lability NN 10_1101-2020_03_27_012757 260 9 of of IN 10_1101-2020_03_27_012757 260 10 the the DT 10_1101-2020_03_27_012757 260 11 ESCA ESCA NNP 10_1101-2020_03_27_012757 260 12 523 523 CD 10_1101-2020_03_27_012757 260 13 transcriptome transcriptome VBP 10_1101-2020_03_27_012757 260 14 that that WDT 10_1101-2020_03_27_012757 260 15 is be VBZ 10_1101-2020_03_27_012757 260 16 often often RB 10_1101-2020_03_27_012757 260 17 preceded precede VBN 10_1101-2020_03_27_012757 260 18 by by IN 10_1101-2020_03_27_012757 260 19 a a DT 10_1101-2020_03_27_012757 260 20 metaplasia metaplasia NN 10_1101-2020_03_27_012757 260 21 that that WDT 10_1101-2020_03_27_012757 260 22 has have VBZ 10_1101-2020_03_27_012757 260 23 obscured obscure VBN 10_1101-2020_03_27_012757 260 24 determining determine VBG 10_1101-2020_03_27_012757 260 25 its -PRON- PRP$ 10_1101-2020_03_27_012757 260 26 cell cell NN 10_1101-2020_03_27_012757 260 27 524 524 CD 10_1101-2020_03_27_012757 260 28 type(s type(s NNP 10_1101-2020_03_27_012757 260 29 ) ) -RRB- 10_1101-2020_03_27_012757 260 30 of of IN 10_1101-2020_03_27_012757 260 31 origin78 origin78 NNP 10_1101-2020_03_27_012757 260 32 . . . 10_1101-2020_03_27_012757 261 1 Therefore therefore RB 10_1101-2020_03_27_012757 261 2 , , , 10_1101-2020_03_27_012757 261 3 this this DT 10_1101-2020_03_27_012757 261 4 tumor tumor NN 10_1101-2020_03_27_012757 261 5 type type NN 10_1101-2020_03_27_012757 261 6 requires require VBZ 10_1101-2020_03_27_012757 261 7 further further JJ 10_1101-2020_03_27_012757 261 8 attention attention NN 10_1101-2020_03_27_012757 261 9 to to TO 10_1101-2020_03_27_012757 261 10 derive derive VB 10_1101-2020_03_27_012757 261 11 new new JJ 10_1101-2020_03_27_012757 261 12 models model NNS 10_1101-2020_03_27_012757 261 13 . . . 10_1101-2020_03_27_012757 262 1 525 525 CD 10_1101-2020_03_27_012757 262 2 .CC .CC : 10_1101-2020_03_27_012757 262 3 - - HYPH 10_1101-2020_03_27_012757 262 4 BY by IN 10_1101-2020_03_27_012757 262 5 - - HYPH 10_1101-2020_03_27_012757 262 6 NC NC NNP 10_1101-2020_03_27_012757 262 7 - - HYPH 10_1101-2020_03_27_012757 262 8 ND ND NNP 10_1101-2020_03_27_012757 262 9 4.0 4.0 CD 10_1101-2020_03_27_012757 262 10 International International NNP 10_1101-2020_03_27_012757 262 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 262 12 under under IN 10_1101-2020_03_27_012757 262 13 a a DT 10_1101-2020_03_27_012757 262 14 ( ( -LRB- 10_1101-2020_03_27_012757 262 15 which which WDT 10_1101-2020_03_27_012757 262 16 was be VBD 10_1101-2020_03_27_012757 262 17 not not RB 10_1101-2020_03_27_012757 262 18 certified certify VBN 10_1101-2020_03_27_012757 262 19 by by IN 10_1101-2020_03_27_012757 262 20 peer peer NN 10_1101-2020_03_27_012757 262 21 review review NN 10_1101-2020_03_27_012757 262 22 ) ) -RRB- 10_1101-2020_03_27_012757 262 23 is be VBZ 10_1101-2020_03_27_012757 262 24 the the DT 10_1101-2020_03_27_012757 262 25 author author NN 10_1101-2020_03_27_012757 262 26 / / SYM 10_1101-2020_03_27_012757 262 27 funder funder NN 10_1101-2020_03_27_012757 262 28 , , , 10_1101-2020_03_27_012757 262 29 who who WP 10_1101-2020_03_27_012757 262 30 has have VBZ 10_1101-2020_03_27_012757 262 31 granted grant VBN 10_1101-2020_03_27_012757 262 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 262 33 a a DT 10_1101-2020_03_27_012757 262 34 license license NN 10_1101-2020_03_27_012757 262 35 to to TO 10_1101-2020_03_27_012757 262 36 display display VB 10_1101-2020_03_27_012757 262 37 the the DT 10_1101-2020_03_27_012757 262 38 preprint preprint NN 10_1101-2020_03_27_012757 262 39 in in IN 10_1101-2020_03_27_012757 262 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 262 41 . . . 10_1101-2020_03_27_012757 263 1 It -PRON- PRP 10_1101-2020_03_27_012757 263 2 is be VBZ 10_1101-2020_03_27_012757 263 3 made make VBN 10_1101-2020_03_27_012757 263 4 The the DT 10_1101-2020_03_27_012757 263 5 copyright copyright NN 10_1101-2020_03_27_012757 263 6 holder holder NN 10_1101-2020_03_27_012757 263 7 for for IN 10_1101-2020_03_27_012757 263 8 this this DT 10_1101-2020_03_27_012757 263 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 263 10 version version NN 10_1101-2020_03_27_012757 263 11 posted post VBD 10_1101-2020_03_27_012757 263 12 January January NNP 10_1101-2020_03_27_012757 263 13 9 9 CD 10_1101-2020_03_27_012757 263 14 , , , 10_1101-2020_03_27_012757 263 15 2021 2021 CD 10_1101-2020_03_27_012757 263 16 . . . 10_1101-2020_03_27_012757 263 17 ; ; : 10_1101-2020_03_27_012757 263 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 263 19 : : : 10_1101-2020_03_27_012757 263 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 263 21 preprint preprint NN 10_1101-2020_03_27_012757 263 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 263 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ RB 10_1101-2020_03_27_012757 263 24 20 20 CD 10_1101-2020_03_27_012757 263 25 Fourth Fourth NNP 10_1101-2020_03_27_012757 263 26 , , , 10_1101-2020_03_27_012757 263 27 we -PRON- PRP 10_1101-2020_03_27_012757 263 28 found find VBD 10_1101-2020_03_27_012757 263 29 that that IN 10_1101-2020_03_27_012757 263 30 in in IN 10_1101-2020_03_27_012757 263 31 several several JJ 10_1101-2020_03_27_012757 263 32 tumor tumor NN 10_1101-2020_03_27_012757 263 33 types type NNS 10_1101-2020_03_27_012757 263 34 , , , 10_1101-2020_03_27_012757 263 35 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 263 36 tend tend VBP 10_1101-2020_03_27_012757 263 37 to to TO 10_1101-2020_03_27_012757 263 38 reflect reflect VB 10_1101-2020_03_27_012757 263 39 mixtures mixture NNS 10_1101-2020_03_27_012757 263 40 of of IN 10_1101-2020_03_27_012757 263 41 526 526 CD 10_1101-2020_03_27_012757 263 42 subtypes subtype NNS 10_1101-2020_03_27_012757 263 43 rather rather RB 10_1101-2020_03_27_012757 263 44 than than IN 10_1101-2020_03_27_012757 263 45 conforming conform VBG 10_1101-2020_03_27_012757 263 46 strongly strongly RB 10_1101-2020_03_27_012757 263 47 to to IN 10_1101-2020_03_27_012757 263 48 single single JJ 10_1101-2020_03_27_012757 263 49 subtypes subtype NNS 10_1101-2020_03_27_012757 263 50 . . . 10_1101-2020_03_27_012757 264 1 The the DT 10_1101-2020_03_27_012757 264 2 reasons reason NNS 10_1101-2020_03_27_012757 264 3 for for IN 10_1101-2020_03_27_012757 264 4 this this DT 10_1101-2020_03_27_012757 264 5 are be VBP 10_1101-2020_03_27_012757 264 6 not not RB 10_1101-2020_03_27_012757 264 7 clear clear JJ 10_1101-2020_03_27_012757 264 8 527 527 CD 10_1101-2020_03_27_012757 264 9 but but CC 10_1101-2020_03_27_012757 264 10 it -PRON- PRP 10_1101-2020_03_27_012757 264 11 is be VBZ 10_1101-2020_03_27_012757 264 12 possible possible JJ 10_1101-2020_03_27_012757 264 13 that that IN 10_1101-2020_03_27_012757 264 14 in in IN 10_1101-2020_03_27_012757 264 15 the the DT 10_1101-2020_03_27_012757 264 16 cases case NNS 10_1101-2020_03_27_012757 264 17 that that WDT 10_1101-2020_03_27_012757 264 18 we -PRON- PRP 10_1101-2020_03_27_012757 264 19 examined examine VBD 10_1101-2020_03_27_012757 264 20 the the DT 10_1101-2020_03_27_012757 264 21 histologically histologically RB 10_1101-2020_03_27_012757 264 22 defined define VBN 10_1101-2020_03_27_012757 264 23 subtypes subtype NNS 10_1101-2020_03_27_012757 264 24 have have VBP 10_1101-2020_03_27_012757 264 25 a a DT 10_1101-2020_03_27_012757 264 26 528 528 CD 10_1101-2020_03_27_012757 264 27 degree degree NN 10_1101-2020_03_27_012757 264 28 of of IN 10_1101-2020_03_27_012757 264 29 plasticity plasticity NN 10_1101-2020_03_27_012757 264 30 that that WDT 10_1101-2020_03_27_012757 264 31 is be VBZ 10_1101-2020_03_27_012757 264 32 exacerbated exacerbate VBN 10_1101-2020_03_27_012757 264 33 in in IN 10_1101-2020_03_27_012757 264 34 the the DT 10_1101-2020_03_27_012757 264 35 murine murine NN 10_1101-2020_03_27_012757 264 36 host host NN 10_1101-2020_03_27_012757 264 37 environment environment NN 10_1101-2020_03_27_012757 264 38 . . . 10_1101-2020_03_27_012757 265 1 529 529 CD 10_1101-2020_03_27_012757 265 2 Lastly lastly RB 10_1101-2020_03_27_012757 265 3 , , , 10_1101-2020_03_27_012757 265 4 we -PRON- PRP 10_1101-2020_03_27_012757 265 5 recognize recognize VBP 10_1101-2020_03_27_012757 265 6 that that IN 10_1101-2020_03_27_012757 265 7 many many JJ 10_1101-2020_03_27_012757 265 8 CCLs ccl NNS 10_1101-2020_03_27_012757 265 9 are be VBP 10_1101-2020_03_27_012757 265 10 not not RB 10_1101-2020_03_27_012757 265 11 classified classify VBN 10_1101-2020_03_27_012757 265 12 as as IN 10_1101-2020_03_27_012757 265 13 their -PRON- PRP$ 10_1101-2020_03_27_012757 265 14 annotated annotate VBN 10_1101-2020_03_27_012757 265 15 labels label NNS 10_1101-2020_03_27_012757 265 16 . . . 10_1101-2020_03_27_012757 266 1 While while IN 10_1101-2020_03_27_012757 266 2 530 530 CD 10_1101-2020_03_27_012757 266 3 we -PRON- PRP 10_1101-2020_03_27_012757 266 4 have have VBP 10_1101-2020_03_27_012757 266 5 suggested suggest VBN 10_1101-2020_03_27_012757 266 6 that that IN 10_1101-2020_03_27_012757 266 7 the the DT 10_1101-2020_03_27_012757 266 8 lack lack NN 10_1101-2020_03_27_012757 266 9 of of IN 10_1101-2020_03_27_012757 266 10 immune immune JJ 10_1101-2020_03_27_012757 266 11 component component NN 10_1101-2020_03_27_012757 266 12 is be VBZ 10_1101-2020_03_27_012757 266 13 not not RB 10_1101-2020_03_27_012757 266 14 a a DT 10_1101-2020_03_27_012757 266 15 major major JJ 10_1101-2020_03_27_012757 266 16 confounder confounder NN 10_1101-2020_03_27_012757 266 17 , , , 10_1101-2020_03_27_012757 266 18 we -PRON- PRP 10_1101-2020_03_27_012757 266 19 suspect suspect VBP 10_1101-2020_03_27_012757 266 20 531 531 CD 10_1101-2020_03_27_012757 266 21 that that IN 10_1101-2020_03_27_012757 266 22 the the DT 10_1101-2020_03_27_012757 266 23 CCLs ccl NNS 10_1101-2020_03_27_012757 266 24 could could MD 10_1101-2020_03_27_012757 266 25 undergo undergo VB 10_1101-2020_03_27_012757 266 26 genetic genetic JJ 10_1101-2020_03_27_012757 266 27 divergence divergence NN 10_1101-2020_03_27_012757 266 28 due due JJ 10_1101-2020_03_27_012757 266 29 to to IN 10_1101-2020_03_27_012757 266 30 high high JJ 10_1101-2020_03_27_012757 266 31 number number NN 10_1101-2020_03_27_012757 266 32 of of IN 10_1101-2020_03_27_012757 266 33 passages passage NNS 10_1101-2020_03_27_012757 266 34 , , , 10_1101-2020_03_27_012757 266 35 532 532 CD 10_1101-2020_03_27_012757 266 36 chemotherapy chemotherapy NN 10_1101-2020_03_27_012757 266 37 before before IN 10_1101-2020_03_27_012757 266 38 biopsy biopsy NN 10_1101-2020_03_27_012757 266 39 , , , 10_1101-2020_03_27_012757 266 40 culture culture NN 10_1101-2020_03_27_012757 266 41 condition condition NN 10_1101-2020_03_27_012757 266 42 and and CC 10_1101-2020_03_27_012757 266 43 genetic genetic JJ 10_1101-2020_03_27_012757 266 44 instability79–82 instability79–82 NNS 10_1101-2020_03_27_012757 266 45 , , , 10_1101-2020_03_27_012757 266 46 which which WDT 10_1101-2020_03_27_012757 266 47 could could MD 10_1101-2020_03_27_012757 266 48 all all DT 10_1101-2020_03_27_012757 266 49 be be VB 10_1101-2020_03_27_012757 266 50 533 533 CD 10_1101-2020_03_27_012757 266 51 factors factor NNS 10_1101-2020_03_27_012757 266 52 that that WDT 10_1101-2020_03_27_012757 266 53 drive drive VBP 10_1101-2020_03_27_012757 266 54 CCLs ccl NNS 10_1101-2020_03_27_012757 266 55 away away RB 10_1101-2020_03_27_012757 266 56 from from IN 10_1101-2020_03_27_012757 266 57 their -PRON- PRP$ 10_1101-2020_03_27_012757 266 58 labelled label VBN 10_1101-2020_03_27_012757 266 59 tumors tumor NNS 10_1101-2020_03_27_012757 266 60 . . . 10_1101-2020_03_27_012757 267 1 534 534 CD 10_1101-2020_03_27_012757 267 2 Currently currently RB 10_1101-2020_03_27_012757 267 3 , , , 10_1101-2020_03_27_012757 267 4 there there EX 10_1101-2020_03_27_012757 267 5 are be VBP 10_1101-2020_03_27_012757 267 6 several several JJ 10_1101-2020_03_27_012757 267 7 limitations limitation NNS 10_1101-2020_03_27_012757 267 8 to to IN 10_1101-2020_03_27_012757 267 9 our -PRON- PRP$ 10_1101-2020_03_27_012757 267 10 CCN CCN NNP 10_1101-2020_03_27_012757 267 11 tool tool NN 10_1101-2020_03_27_012757 267 12 , , , 10_1101-2020_03_27_012757 267 13 and and CC 10_1101-2020_03_27_012757 267 14 caveats caveat NNS 10_1101-2020_03_27_012757 267 15 to to IN 10_1101-2020_03_27_012757 267 16 our -PRON- PRP$ 10_1101-2020_03_27_012757 267 17 analyses analysis NNS 10_1101-2020_03_27_012757 267 18 535 535 CD 10_1101-2020_03_27_012757 267 19 which which WDT 10_1101-2020_03_27_012757 267 20 indicate indicate VBP 10_1101-2020_03_27_012757 267 21 areas area NNS 10_1101-2020_03_27_012757 267 22 for for IN 10_1101-2020_03_27_012757 267 23 future future JJ 10_1101-2020_03_27_012757 267 24 work work NN 10_1101-2020_03_27_012757 267 25 and and CC 10_1101-2020_03_27_012757 267 26 improvement improvement NN 10_1101-2020_03_27_012757 267 27 . . . 10_1101-2020_03_27_012757 268 1 First first RB 10_1101-2020_03_27_012757 268 2 , , , 10_1101-2020_03_27_012757 268 3 CCN CCN NNP 10_1101-2020_03_27_012757 268 4 is be VBZ 10_1101-2020_03_27_012757 268 5 based base VBN 10_1101-2020_03_27_012757 268 6 on on IN 10_1101-2020_03_27_012757 268 7 transcriptomic transcriptomic JJ 10_1101-2020_03_27_012757 268 8 536 536 CD 10_1101-2020_03_27_012757 268 9 data datum NNS 10_1101-2020_03_27_012757 268 10 but but CC 10_1101-2020_03_27_012757 268 11 other other JJ 10_1101-2020_03_27_012757 268 12 molecular molecular JJ 10_1101-2020_03_27_012757 268 13 readouts readout NNS 10_1101-2020_03_27_012757 268 14 of of IN 10_1101-2020_03_27_012757 268 15 tumor tumor NN 10_1101-2020_03_27_012757 268 16 state state NN 10_1101-2020_03_27_012757 268 17 , , , 10_1101-2020_03_27_012757 268 18 such such JJ 10_1101-2020_03_27_012757 268 19 as as IN 10_1101-2020_03_27_012757 268 20 profiles profile NNS 10_1101-2020_03_27_012757 268 21 of of IN 10_1101-2020_03_27_012757 268 22 the the DT 10_1101-2020_03_27_012757 268 23 proteome83 proteome83 NN 10_1101-2020_03_27_012757 268 24 , , , 10_1101-2020_03_27_012757 268 25 537 537 CD 10_1101-2020_03_27_012757 268 26 epigenome84 epigenome84 RB 10_1101-2020_03_27_012757 268 27 , , , 10_1101-2020_03_27_012757 268 28 non non JJ 10_1101-2020_03_27_012757 268 29 - - JJ 10_1101-2020_03_27_012757 268 30 coding coding JJ 10_1101-2020_03_27_012757 268 31 RNA RNA NNP 10_1101-2020_03_27_012757 268 32 - - HYPH 10_1101-2020_03_27_012757 268 33 ome84 ome84 NNP 10_1101-2020_03_27_012757 268 34 , , , 10_1101-2020_03_27_012757 268 35 and and CC 10_1101-2020_03_27_012757 268 36 genome74 genome74 NNP 10_1101-2020_03_27_012757 268 37 would would MD 10_1101-2020_03_27_012757 268 38 be be VB 10_1101-2020_03_27_012757 268 39 equally equally RB 10_1101-2020_03_27_012757 268 40 , , , 10_1101-2020_03_27_012757 268 41 if if IN 10_1101-2020_03_27_012757 268 42 not not RB 10_1101-2020_03_27_012757 268 43 more more RBR 10_1101-2020_03_27_012757 268 44 important important JJ 10_1101-2020_03_27_012757 268 45 , , , 10_1101-2020_03_27_012757 268 46 to to IN 10_1101-2020_03_27_012757 268 47 538 538 CD 10_1101-2020_03_27_012757 268 48 mimic mimic NN 10_1101-2020_03_27_012757 268 49 in in IN 10_1101-2020_03_27_012757 268 50 a a DT 10_1101-2020_03_27_012757 268 51 model model NN 10_1101-2020_03_27_012757 268 52 system system NN 10_1101-2020_03_27_012757 268 53 . . . 10_1101-2020_03_27_012757 269 1 Therefore therefore RB 10_1101-2020_03_27_012757 269 2 , , , 10_1101-2020_03_27_012757 269 3 it -PRON- PRP 10_1101-2020_03_27_012757 269 4 is be VBZ 10_1101-2020_03_27_012757 269 5 possible possible JJ 10_1101-2020_03_27_012757 269 6 that that IN 10_1101-2020_03_27_012757 269 7 some some DT 10_1101-2020_03_27_012757 269 8 models model NNS 10_1101-2020_03_27_012757 269 9 reflect reflect VBP 10_1101-2020_03_27_012757 269 10 tumor tumor NN 10_1101-2020_03_27_012757 269 11 behavior behavior NN 10_1101-2020_03_27_012757 269 12 well well RB 10_1101-2020_03_27_012757 269 13 , , , 10_1101-2020_03_27_012757 269 14 539 539 CD 10_1101-2020_03_27_012757 269 15 and and CC 10_1101-2020_03_27_012757 269 16 because because IN 10_1101-2020_03_27_012757 269 17 this this DT 10_1101-2020_03_27_012757 269 18 behavior behavior NN 10_1101-2020_03_27_012757 269 19 is be VBZ 10_1101-2020_03_27_012757 269 20 not not RB 10_1101-2020_03_27_012757 269 21 well well RB 10_1101-2020_03_27_012757 269 22 predicted predict VBN 10_1101-2020_03_27_012757 269 23 by by IN 10_1101-2020_03_27_012757 269 24 transcriptome transcriptome DT 10_1101-2020_03_27_012757 269 25 alone alone RB 10_1101-2020_03_27_012757 269 26 , , , 10_1101-2020_03_27_012757 269 27 these these DT 10_1101-2020_03_27_012757 269 28 models model NNS 10_1101-2020_03_27_012757 269 29 have have VBP 10_1101-2020_03_27_012757 269 30 540 540 CD 10_1101-2020_03_27_012757 269 31 lower low JJR 10_1101-2020_03_27_012757 269 32 CCN CCN NNP 10_1101-2020_03_27_012757 269 33 scores score NNS 10_1101-2020_03_27_012757 269 34 . . . 10_1101-2020_03_27_012757 270 1 To to TO 10_1101-2020_03_27_012757 270 2 both both DT 10_1101-2020_03_27_012757 270 3 measure measure VB 10_1101-2020_03_27_012757 270 4 the the DT 10_1101-2020_03_27_012757 270 5 extent extent NN 10_1101-2020_03_27_012757 270 6 that that IN 10_1101-2020_03_27_012757 270 7 such such JJ 10_1101-2020_03_27_012757 270 8 situations situation NNS 10_1101-2020_03_27_012757 270 9 exist exist VBP 10_1101-2020_03_27_012757 270 10 , , , 10_1101-2020_03_27_012757 270 11 and and CC 10_1101-2020_03_27_012757 270 12 to to TO 10_1101-2020_03_27_012757 270 13 correct correct VB 10_1101-2020_03_27_012757 270 14 for for IN 10_1101-2020_03_27_012757 270 15 541 541 CD 10_1101-2020_03_27_012757 270 16 them -PRON- PRP 10_1101-2020_03_27_012757 270 17 , , , 10_1101-2020_03_27_012757 270 18 we -PRON- PRP 10_1101-2020_03_27_012757 270 19 plan plan VBP 10_1101-2020_03_27_012757 270 20 in in IN 10_1101-2020_03_27_012757 270 21 the the DT 10_1101-2020_03_27_012757 270 22 future future NN 10_1101-2020_03_27_012757 270 23 to to TO 10_1101-2020_03_27_012757 270 24 incorporate incorporate VB 10_1101-2020_03_27_012757 270 25 other other JJ 10_1101-2020_03_27_012757 270 26 omic omic JJ 10_1101-2020_03_27_012757 270 27 data datum NNS 10_1101-2020_03_27_012757 270 28 into into IN 10_1101-2020_03_27_012757 270 29 CCN CCN NNP 10_1101-2020_03_27_012757 270 30 so so IN 10_1101-2020_03_27_012757 270 31 as as IN 10_1101-2020_03_27_012757 270 32 to to TO 10_1101-2020_03_27_012757 270 33 make make VB 10_1101-2020_03_27_012757 270 34 more more JJR 10_1101-2020_03_27_012757 270 35 542 542 CD 10_1101-2020_03_27_012757 270 36 accurate accurate JJ 10_1101-2020_03_27_012757 270 37 and and CC 10_1101-2020_03_27_012757 270 38 integrated integrated JJ 10_1101-2020_03_27_012757 270 39 model model NN 10_1101-2020_03_27_012757 270 40 evaluation evaluation NN 10_1101-2020_03_27_012757 270 41 possible possible JJ 10_1101-2020_03_27_012757 270 42 . . . 10_1101-2020_03_27_012757 271 1 As as IN 10_1101-2020_03_27_012757 271 2 a a DT 10_1101-2020_03_27_012757 271 3 first first JJ 10_1101-2020_03_27_012757 271 4 step step NN 10_1101-2020_03_27_012757 271 5 in in IN 10_1101-2020_03_27_012757 271 6 this this DT 10_1101-2020_03_27_012757 271 7 direction direction NN 10_1101-2020_03_27_012757 271 8 , , , 10_1101-2020_03_27_012757 271 9 we -PRON- PRP 10_1101-2020_03_27_012757 271 10 plan plan VBP 10_1101-2020_03_27_012757 271 11 to to IN 10_1101-2020_03_27_012757 271 12 543 543 CD 10_1101-2020_03_27_012757 271 13 incorporate incorporate JJ 10_1101-2020_03_27_012757 271 14 DNA dna NN 10_1101-2020_03_27_012757 271 15 methylation methylation NN 10_1101-2020_03_27_012757 271 16 and and CC 10_1101-2020_03_27_012757 271 17 genomic genomic JJ 10_1101-2020_03_27_012757 271 18 sequencing sequencing NN 10_1101-2020_03_27_012757 271 19 data datum NNS 10_1101-2020_03_27_012757 271 20 as as IN 10_1101-2020_03_27_012757 271 21 additional additional JJ 10_1101-2020_03_27_012757 271 22 features feature NNS 10_1101-2020_03_27_012757 271 23 for for IN 10_1101-2020_03_27_012757 271 24 our -PRON- PRP$ 10_1101-2020_03_27_012757 271 25 544 544 CD 10_1101-2020_03_27_012757 271 26 Random random JJ 10_1101-2020_03_27_012757 271 27 forest forest NN 10_1101-2020_03_27_012757 271 28 classifier classifier NN 10_1101-2020_03_27_012757 271 29 as as IN 10_1101-2020_03_27_012757 271 30 this this DT 10_1101-2020_03_27_012757 271 31 data data NN 10_1101-2020_03_27_012757 271 32 is be VBZ 10_1101-2020_03_27_012757 271 33 becoming become VBG 10_1101-2020_03_27_012757 271 34 more more RBR 10_1101-2020_03_27_012757 271 35 readily readily RB 10_1101-2020_03_27_012757 271 36 available available JJ 10_1101-2020_03_27_012757 271 37 for for IN 10_1101-2020_03_27_012757 271 38 both both DT 10_1101-2020_03_27_012757 271 39 training training NN 10_1101-2020_03_27_012757 271 40 and and CC 10_1101-2020_03_27_012757 271 41 545 545 CD 10_1101-2020_03_27_012757 271 42 cancer cancer NN 10_1101-2020_03_27_012757 271 43 models model NNS 10_1101-2020_03_27_012757 271 44 . . . 10_1101-2020_03_27_012757 272 1 We -PRON- PRP 10_1101-2020_03_27_012757 272 2 expect expect VBP 10_1101-2020_03_27_012757 272 3 that that IN 10_1101-2020_03_27_012757 272 4 this this DT 10_1101-2020_03_27_012757 272 5 will will MD 10_1101-2020_03_27_012757 272 6 allow allow VB 10_1101-2020_03_27_012757 272 7 us -PRON- PRP 10_1101-2020_03_27_012757 272 8 to to IN 10_1101-2020_03_27_012757 272 9 both both DT 10_1101-2020_03_27_012757 272 10 refine refine VB 10_1101-2020_03_27_012757 272 11 our -PRON- PRP$ 10_1101-2020_03_27_012757 272 12 tumor tumor NN 10_1101-2020_03_27_012757 272 13 subtype subtype NN 10_1101-2020_03_27_012757 272 14 categories category NNS 10_1101-2020_03_27_012757 272 15 and and CC 10_1101-2020_03_27_012757 272 16 546 546 CD 10_1101-2020_03_27_012757 272 17 it -PRON- PRP 10_1101-2020_03_27_012757 272 18 will will MD 10_1101-2020_03_27_012757 272 19 enable enable VB 10_1101-2020_03_27_012757 272 20 more more RBR 10_1101-2020_03_27_012757 272 21 accurate accurate JJ 10_1101-2020_03_27_012757 272 22 predictions prediction NNS 10_1101-2020_03_27_012757 272 23 of of IN 10_1101-2020_03_27_012757 272 24 how how WRB 10_1101-2020_03_27_012757 272 25 models model NNS 10_1101-2020_03_27_012757 272 26 respond respond VBP 10_1101-2020_03_27_012757 272 27 to to IN 10_1101-2020_03_27_012757 272 28 perturbations perturbation NNS 10_1101-2020_03_27_012757 272 29 such such JJ 10_1101-2020_03_27_012757 272 30 as as IN 10_1101-2020_03_27_012757 272 31 drug drug NN 10_1101-2020_03_27_012757 272 32 547 547 CD 10_1101-2020_03_27_012757 272 33 treatment treatment NN 10_1101-2020_03_27_012757 272 34 . . . 10_1101-2020_03_27_012757 273 1 548 548 CD 10_1101-2020_03_27_012757 273 2 A a DT 10_1101-2020_03_27_012757 273 3 second second JJ 10_1101-2020_03_27_012757 273 4 limitation limitation NN 10_1101-2020_03_27_012757 273 5 is be VBZ 10_1101-2020_03_27_012757 273 6 that that IN 10_1101-2020_03_27_012757 273 7 in in IN 10_1101-2020_03_27_012757 273 8 the the DT 10_1101-2020_03_27_012757 273 9 cross cross JJ 10_1101-2020_03_27_012757 273 10 - - JJ 10_1101-2020_03_27_012757 273 11 species species JJ 10_1101-2020_03_27_012757 273 12 analysis analysis NN 10_1101-2020_03_27_012757 273 13 , , , 10_1101-2020_03_27_012757 273 14 CCN CCN NNP 10_1101-2020_03_27_012757 273 15 implicitly implicitly RB 10_1101-2020_03_27_012757 273 16 assumes assume VBZ 10_1101-2020_03_27_012757 273 17 that that IN 10_1101-2020_03_27_012757 273 18 549 549 CD 10_1101-2020_03_27_012757 273 19 homologs homolog NNS 10_1101-2020_03_27_012757 273 20 are be VBP 10_1101-2020_03_27_012757 273 21 functionally functionally RB 10_1101-2020_03_27_012757 273 22 equivalent equivalent JJ 10_1101-2020_03_27_012757 273 23 . . . 10_1101-2020_03_27_012757 274 1 The the DT 10_1101-2020_03_27_012757 274 2 extent extent NN 10_1101-2020_03_27_012757 274 3 to to TO 10_1101-2020_03_27_012757 274 4 which which WDT 10_1101-2020_03_27_012757 274 5 they -PRON- PRP 10_1101-2020_03_27_012757 274 6 are be VBP 10_1101-2020_03_27_012757 274 7 not not RB 10_1101-2020_03_27_012757 274 8 functionally functionally RB 10_1101-2020_03_27_012757 274 9 equivalent equivalent JJ 10_1101-2020_03_27_012757 274 10 550 550 CD 10_1101-2020_03_27_012757 274 11 determines determine NNS 10_1101-2020_03_27_012757 274 12 how how WRB 10_1101-2020_03_27_012757 274 13 confounded confound VBD 10_1101-2020_03_27_012757 274 14 the the DT 10_1101-2020_03_27_012757 274 15 CCN CCN NNP 10_1101-2020_03_27_012757 274 16 results result NNS 10_1101-2020_03_27_012757 274 17 will will MD 10_1101-2020_03_27_012757 274 18 be be VB 10_1101-2020_03_27_012757 274 19 . . . 10_1101-2020_03_27_012757 275 1 This this DT 10_1101-2020_03_27_012757 275 2 possibility possibility NN 10_1101-2020_03_27_012757 275 3 seems seem VBZ 10_1101-2020_03_27_012757 275 4 to to TO 10_1101-2020_03_27_012757 275 5 be be VB 10_1101-2020_03_27_012757 275 6 of of IN 10_1101-2020_03_27_012757 275 7 limited limited JJ 10_1101-2020_03_27_012757 275 8 551 551 CD 10_1101-2020_03_27_012757 275 9 .CC .CC : 10_1101-2020_03_27_012757 275 10 - - : 10_1101-2020_03_27_012757 275 11 BY by IN 10_1101-2020_03_27_012757 275 12 - - HYPH 10_1101-2020_03_27_012757 275 13 NC NC NNP 10_1101-2020_03_27_012757 275 14 - - HYPH 10_1101-2020_03_27_012757 275 15 ND ND NNP 10_1101-2020_03_27_012757 275 16 4.0 4.0 CD 10_1101-2020_03_27_012757 275 17 International International NNP 10_1101-2020_03_27_012757 275 18 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 275 19 under under IN 10_1101-2020_03_27_012757 275 20 a a DT 10_1101-2020_03_27_012757 275 21 ( ( -LRB- 10_1101-2020_03_27_012757 275 22 which which WDT 10_1101-2020_03_27_012757 275 23 was be VBD 10_1101-2020_03_27_012757 275 24 not not RB 10_1101-2020_03_27_012757 275 25 certified certify VBN 10_1101-2020_03_27_012757 275 26 by by IN 10_1101-2020_03_27_012757 275 27 peer peer NN 10_1101-2020_03_27_012757 275 28 review review NN 10_1101-2020_03_27_012757 275 29 ) ) -RRB- 10_1101-2020_03_27_012757 275 30 is be VBZ 10_1101-2020_03_27_012757 275 31 the the DT 10_1101-2020_03_27_012757 275 32 author author NN 10_1101-2020_03_27_012757 275 33 / / SYM 10_1101-2020_03_27_012757 275 34 funder funder NN 10_1101-2020_03_27_012757 275 35 , , , 10_1101-2020_03_27_012757 275 36 who who WP 10_1101-2020_03_27_012757 275 37 has have VBZ 10_1101-2020_03_27_012757 275 38 granted grant VBN 10_1101-2020_03_27_012757 275 39 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 275 40 a a DT 10_1101-2020_03_27_012757 275 41 license license NN 10_1101-2020_03_27_012757 275 42 to to TO 10_1101-2020_03_27_012757 275 43 display display VB 10_1101-2020_03_27_012757 275 44 the the DT 10_1101-2020_03_27_012757 275 45 preprint preprint NN 10_1101-2020_03_27_012757 275 46 in in IN 10_1101-2020_03_27_012757 275 47 perpetuity perpetuity NN 10_1101-2020_03_27_012757 275 48 . . . 10_1101-2020_03_27_012757 276 1 It -PRON- PRP 10_1101-2020_03_27_012757 276 2 is be VBZ 10_1101-2020_03_27_012757 276 3 made make VBN 10_1101-2020_03_27_012757 276 4 The the DT 10_1101-2020_03_27_012757 276 5 copyright copyright NN 10_1101-2020_03_27_012757 276 6 holder holder NN 10_1101-2020_03_27_012757 276 7 for for IN 10_1101-2020_03_27_012757 276 8 this this DT 10_1101-2020_03_27_012757 276 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 276 10 version version NN 10_1101-2020_03_27_012757 276 11 posted post VBD 10_1101-2020_03_27_012757 276 12 January January NNP 10_1101-2020_03_27_012757 276 13 9 9 CD 10_1101-2020_03_27_012757 276 14 , , , 10_1101-2020_03_27_012757 276 15 2021 2021 CD 10_1101-2020_03_27_012757 276 16 . . . 10_1101-2020_03_27_012757 276 17 ; ; : 10_1101-2020_03_27_012757 276 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 276 19 : : : 10_1101-2020_03_27_012757 276 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 276 21 preprint preprint NN 10_1101-2020_03_27_012757 276 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 276 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 276 24 21 21 CD 10_1101-2020_03_27_012757 276 25 consequence consequence NN 10_1101-2020_03_27_012757 276 26 based base VBN 10_1101-2020_03_27_012757 276 27 on on IN 10_1101-2020_03_27_012757 276 28 the the DT 10_1101-2020_03_27_012757 276 29 high high JJ 10_1101-2020_03_27_012757 276 30 performance performance NN 10_1101-2020_03_27_012757 276 31 of of IN 10_1101-2020_03_27_012757 276 32 the the DT 10_1101-2020_03_27_012757 276 33 normal normal JJ 10_1101-2020_03_27_012757 276 34 tissue tissue NN 10_1101-2020_03_27_012757 276 35 cross cross NN 10_1101-2020_03_27_012757 276 36 - - JJ 10_1101-2020_03_27_012757 276 37 species species JJ 10_1101-2020_03_27_012757 276 38 classifier classifier NN 10_1101-2020_03_27_012757 276 39 and and CC 10_1101-2020_03_27_012757 276 40 552 552 CD 10_1101-2020_03_27_012757 276 41 based base VBN 10_1101-2020_03_27_012757 276 42 on on IN 10_1101-2020_03_27_012757 276 43 the the DT 10_1101-2020_03_27_012757 276 44 fact fact NN 10_1101-2020_03_27_012757 276 45 that that IN 10_1101-2020_03_27_012757 276 46 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 276 47 have have VBP 10_1101-2020_03_27_012757 276 48 the the DT 10_1101-2020_03_27_012757 276 49 highest high JJS 10_1101-2020_03_27_012757 276 50 median median JJ 10_1101-2020_03_27_012757 276 51 CCN CCN NNP 10_1101-2020_03_27_012757 276 52 scores score NNS 10_1101-2020_03_27_012757 276 53 ( ( -LRB- 10_1101-2020_03_27_012757 276 54 in in IN 10_1101-2020_03_27_012757 276 55 addition addition NN 10_1101-2020_03_27_012757 276 56 to to IN 10_1101-2020_03_27_012757 276 57 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 276 58 ) ) -RRB- 10_1101-2020_03_27_012757 276 59 . . . 10_1101-2020_03_27_012757 277 1 553 553 CD 10_1101-2020_03_27_012757 277 2 A a DT 10_1101-2020_03_27_012757 277 3 third third JJ 10_1101-2020_03_27_012757 277 4 caveat caveat NN 10_1101-2020_03_27_012757 277 5 to to IN 10_1101-2020_03_27_012757 277 6 our -PRON- PRP$ 10_1101-2020_03_27_012757 277 7 analysis analysis NN 10_1101-2020_03_27_012757 277 8 is be VBZ 10_1101-2020_03_27_012757 277 9 that that IN 10_1101-2020_03_27_012757 277 10 there there EX 10_1101-2020_03_27_012757 277 11 were be VBD 10_1101-2020_03_27_012757 277 12 many many JJ 10_1101-2020_03_27_012757 277 13 fewer few JJR 10_1101-2020_03_27_012757 277 14 distinct distinct JJ 10_1101-2020_03_27_012757 277 15 GEMMs gemm NNS 10_1101-2020_03_27_012757 277 16 and and CC 10_1101-2020_03_27_012757 277 17 554 554 CD 10_1101-2020_03_27_012757 277 18 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 277 19 than than IN 10_1101-2020_03_27_012757 277 20 CCLs ccl NNS 10_1101-2020_03_27_012757 277 21 and and CC 10_1101-2020_03_27_012757 277 22 PDXs pdx NNS 10_1101-2020_03_27_012757 277 23 . . . 10_1101-2020_03_27_012757 278 1 As as IN 10_1101-2020_03_27_012757 278 2 more more JJR 10_1101-2020_03_27_012757 278 3 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 278 4 profiles profile NNS 10_1101-2020_03_27_012757 278 5 for for IN 10_1101-2020_03_27_012757 278 6 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 278 7 and and CC 10_1101-2020_03_27_012757 278 8 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 278 9 555 555 CD 10_1101-2020_03_27_012757 278 10 emerge emerge NN 10_1101-2020_03_27_012757 278 11 , , , 10_1101-2020_03_27_012757 278 12 this this DT 10_1101-2020_03_27_012757 278 13 comparative comparative JJ 10_1101-2020_03_27_012757 278 14 analysis analysis NN 10_1101-2020_03_27_012757 278 15 should should MD 10_1101-2020_03_27_012757 278 16 be be VB 10_1101-2020_03_27_012757 278 17 revisited revisit VBN 10_1101-2020_03_27_012757 278 18 to to TO 10_1101-2020_03_27_012757 278 19 assess assess VB 10_1101-2020_03_27_012757 278 20 the the DT 10_1101-2020_03_27_012757 278 21 generality generality NN 10_1101-2020_03_27_012757 278 22 of of IN 10_1101-2020_03_27_012757 278 23 our -PRON- PRP$ 10_1101-2020_03_27_012757 278 24 results result NNS 10_1101-2020_03_27_012757 278 25 . . . 10_1101-2020_03_27_012757 279 1 556 556 CD 10_1101-2020_03_27_012757 279 2 Finally finally RB 10_1101-2020_03_27_012757 279 3 , , , 10_1101-2020_03_27_012757 279 4 the the DT 10_1101-2020_03_27_012757 279 5 TCGA TCGA NNP 10_1101-2020_03_27_012757 279 6 training training NN 10_1101-2020_03_27_012757 279 7 data datum NNS 10_1101-2020_03_27_012757 279 8 is be VBZ 10_1101-2020_03_27_012757 279 9 made make VBN 10_1101-2020_03_27_012757 279 10 up up RP 10_1101-2020_03_27_012757 279 11 of of IN 10_1101-2020_03_27_012757 279 12 RNA RNA NNP 10_1101-2020_03_27_012757 279 13 - - HYPH 10_1101-2020_03_27_012757 279 14 Seq Seq NNP 10_1101-2020_03_27_012757 279 15 from from IN 10_1101-2020_03_27_012757 279 16 bulk bulk JJ 10_1101-2020_03_27_012757 279 17 tumor tumor NN 10_1101-2020_03_27_012757 279 18 samples sample NNS 10_1101-2020_03_27_012757 279 19 , , , 10_1101-2020_03_27_012757 279 20 which which WDT 10_1101-2020_03_27_012757 279 21 557 557 CD 10_1101-2020_03_27_012757 279 22 necessarily necessarily RB 10_1101-2020_03_27_012757 279 23 includes include VBZ 10_1101-2020_03_27_012757 279 24 non non JJ 10_1101-2020_03_27_012757 279 25 - - JJ 10_1101-2020_03_27_012757 279 26 tumor tumor JJ 10_1101-2020_03_27_012757 279 27 cells cell NNS 10_1101-2020_03_27_012757 279 28 , , , 10_1101-2020_03_27_012757 279 29 whereas whereas IN 10_1101-2020_03_27_012757 279 30 the the DT 10_1101-2020_03_27_012757 279 31 CCLs ccl NNS 10_1101-2020_03_27_012757 279 32 are be VBP 10_1101-2020_03_27_012757 279 33 by by IN 10_1101-2020_03_27_012757 279 34 definition definition NN 10_1101-2020_03_27_012757 279 35 cell cell NN 10_1101-2020_03_27_012757 279 36 lines line NNS 10_1101-2020_03_27_012757 279 37 of of IN 10_1101-2020_03_27_012757 279 38 tumor tumor NN 10_1101-2020_03_27_012757 279 39 558 558 CD 10_1101-2020_03_27_012757 279 40 origin origin NN 10_1101-2020_03_27_012757 279 41 . . . 10_1101-2020_03_27_012757 280 1 Therefore therefore RB 10_1101-2020_03_27_012757 280 2 , , , 10_1101-2020_03_27_012757 280 3 CCLs CCLs NNPS 10_1101-2020_03_27_012757 280 4 theoretically theoretically RB 10_1101-2020_03_27_012757 280 5 could could MD 10_1101-2020_03_27_012757 280 6 have have VB 10_1101-2020_03_27_012757 280 7 artificially artificially RB 10_1101-2020_03_27_012757 280 8 low low JJ 10_1101-2020_03_27_012757 280 9 CCN CCN NNP 10_1101-2020_03_27_012757 280 10 scores score NNS 10_1101-2020_03_27_012757 280 11 due due IN 10_1101-2020_03_27_012757 280 12 to to IN 10_1101-2020_03_27_012757 280 13 the the DT 10_1101-2020_03_27_012757 280 14 presence presence NN 10_1101-2020_03_27_012757 280 15 559 559 CD 10_1101-2020_03_27_012757 280 16 of of IN 10_1101-2020_03_27_012757 280 17 non non JJ 10_1101-2020_03_27_012757 280 18 - - JJ 10_1101-2020_03_27_012757 280 19 tumor tumor JJ 10_1101-2020_03_27_012757 280 20 cells cell NNS 10_1101-2020_03_27_012757 280 21 in in IN 10_1101-2020_03_27_012757 280 22 the the DT 10_1101-2020_03_27_012757 280 23 training training NN 10_1101-2020_03_27_012757 280 24 data datum NNS 10_1101-2020_03_27_012757 280 25 . . . 10_1101-2020_03_27_012757 281 1 This this DT 10_1101-2020_03_27_012757 281 2 problem problem NN 10_1101-2020_03_27_012757 281 3 appears appear VBZ 10_1101-2020_03_27_012757 281 4 to to TO 10_1101-2020_03_27_012757 281 5 be be VB 10_1101-2020_03_27_012757 281 6 limited limit VBN 10_1101-2020_03_27_012757 281 7 as as IN 10_1101-2020_03_27_012757 281 8 we -PRON- PRP 10_1101-2020_03_27_012757 281 9 found find VBD 10_1101-2020_03_27_012757 281 10 no no DT 10_1101-2020_03_27_012757 281 11 560 560 CD 10_1101-2020_03_27_012757 281 12 correlation correlation NN 10_1101-2020_03_27_012757 281 13 between between IN 10_1101-2020_03_27_012757 281 14 tumor tumor NN 10_1101-2020_03_27_012757 281 15 purity purity NN 10_1101-2020_03_27_012757 281 16 and and CC 10_1101-2020_03_27_012757 281 17 CCN CCN NNP 10_1101-2020_03_27_012757 281 18 score score VBP 10_1101-2020_03_27_012757 281 19 in in IN 10_1101-2020_03_27_012757 281 20 the the DT 10_1101-2020_03_27_012757 281 21 CCLE ccle JJ 10_1101-2020_03_27_012757 281 22 samples sample NNS 10_1101-2020_03_27_012757 281 23 . . . 10_1101-2020_03_27_012757 282 1 However however RB 10_1101-2020_03_27_012757 282 2 , , , 10_1101-2020_03_27_012757 282 3 this this DT 10_1101-2020_03_27_012757 282 4 problem problem NN 10_1101-2020_03_27_012757 282 5 561 561 CD 10_1101-2020_03_27_012757 282 6 is be VBZ 10_1101-2020_03_27_012757 282 7 related relate VBN 10_1101-2020_03_27_012757 282 8 to to IN 10_1101-2020_03_27_012757 282 9 the the DT 10_1101-2020_03_27_012757 282 10 question question NN 10_1101-2020_03_27_012757 282 11 of of IN 10_1101-2020_03_27_012757 282 12 intra intra JJ 10_1101-2020_03_27_012757 282 13 - - JJ 10_1101-2020_03_27_012757 282 14 tumor tumor JJ 10_1101-2020_03_27_012757 282 15 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 282 16 . . . 10_1101-2020_03_27_012757 283 1 We -PRON- PRP 10_1101-2020_03_27_012757 283 2 demonstrated demonstrate VBD 10_1101-2020_03_27_012757 283 3 the the DT 10_1101-2020_03_27_012757 283 4 feasibility feasibility NN 10_1101-2020_03_27_012757 283 5 of of IN 10_1101-2020_03_27_012757 283 6 using use VBG 10_1101-2020_03_27_012757 283 7 562 562 CD 10_1101-2020_03_27_012757 283 8 CCN CCN NNS 10_1101-2020_03_27_012757 283 9 and and CC 10_1101-2020_03_27_012757 283 10 single single JJ 10_1101-2020_03_27_012757 283 11 cell cell NN 10_1101-2020_03_27_012757 283 12 RNA RNA NNP 10_1101-2020_03_27_012757 283 13 - - HYPH 10_1101-2020_03_27_012757 283 14 seq seq NN 10_1101-2020_03_27_012757 283 15 data datum NNS 10_1101-2020_03_27_012757 283 16 to to TO 10_1101-2020_03_27_012757 283 17 refine refine VB 10_1101-2020_03_27_012757 283 18 the the DT 10_1101-2020_03_27_012757 283 19 evaluation evaluation NN 10_1101-2020_03_27_012757 283 20 of of IN 10_1101-2020_03_27_012757 283 21 cancer cancer NN 10_1101-2020_03_27_012757 283 22 cell cell NN 10_1101-2020_03_27_012757 283 23 lines line NNS 10_1101-2020_03_27_012757 283 24 contingent contingent JJ 10_1101-2020_03_27_012757 283 25 upon upon IN 10_1101-2020_03_27_012757 283 26 563 563 CD 10_1101-2020_03_27_012757 283 27 availability availability NN 10_1101-2020_03_27_012757 283 28 of of IN 10_1101-2020_03_27_012757 283 29 scRNA scRNA NNP 10_1101-2020_03_27_012757 283 30 - - HYPH 10_1101-2020_03_27_012757 283 31 seq seq NN 10_1101-2020_03_27_012757 283 32 training training NN 10_1101-2020_03_27_012757 283 33 data datum NNS 10_1101-2020_03_27_012757 283 34 . . . 10_1101-2020_03_27_012757 284 1 As as IN 10_1101-2020_03_27_012757 284 2 more more JJR 10_1101-2020_03_27_012757 284 3 training train VBG 10_1101-2020_03_27_012757 284 4 single single JJ 10_1101-2020_03_27_012757 284 5 cell cell NN 10_1101-2020_03_27_012757 284 6 RNA RNA NNP 10_1101-2020_03_27_012757 284 7 - - HYPH 10_1101-2020_03_27_012757 284 8 seq seq NN 10_1101-2020_03_27_012757 284 9 data datum NNS 10_1101-2020_03_27_012757 284 10 accrues accrue NNS 10_1101-2020_03_27_012757 284 11 , , , 10_1101-2020_03_27_012757 284 12 CCN CCN NNP 10_1101-2020_03_27_012757 284 13 564 564 CD 10_1101-2020_03_27_012757 284 14 would would MD 10_1101-2020_03_27_012757 284 15 be be VB 10_1101-2020_03_27_012757 284 16 able able JJ 10_1101-2020_03_27_012757 284 17 to to TO 10_1101-2020_03_27_012757 284 18 not not RB 10_1101-2020_03_27_012757 284 19 only only RB 10_1101-2020_03_27_012757 284 20 evaluate evaluate VB 10_1101-2020_03_27_012757 284 21 models model NNS 10_1101-2020_03_27_012757 284 22 on on IN 10_1101-2020_03_27_012757 284 23 a a DT 10_1101-2020_03_27_012757 284 24 per per FW 10_1101-2020_03_27_012757 284 25 cell cell NN 10_1101-2020_03_27_012757 284 26 type type NN 10_1101-2020_03_27_012757 284 27 basis basis NN 10_1101-2020_03_27_012757 284 28 , , , 10_1101-2020_03_27_012757 284 29 but but CC 10_1101-2020_03_27_012757 284 30 also also RB 10_1101-2020_03_27_012757 284 31 based base VBN 10_1101-2020_03_27_012757 284 32 on on IN 10_1101-2020_03_27_012757 284 33 cellular cellular JJ 10_1101-2020_03_27_012757 284 34 565 565 CD 10_1101-2020_03_27_012757 284 35 composition composition NN 10_1101-2020_03_27_012757 284 36 . . . 10_1101-2020_03_27_012757 285 1 566 566 CD 10_1101-2020_03_27_012757 285 2 We -PRON- PRP 10_1101-2020_03_27_012757 285 3 have have VBP 10_1101-2020_03_27_012757 285 4 made make VBN 10_1101-2020_03_27_012757 285 5 the the DT 10_1101-2020_03_27_012757 285 6 results result NNS 10_1101-2020_03_27_012757 285 7 of of IN 10_1101-2020_03_27_012757 285 8 our -PRON- PRP$ 10_1101-2020_03_27_012757 285 9 analyses analysis NNS 10_1101-2020_03_27_012757 285 10 available available JJ 10_1101-2020_03_27_012757 285 11 online online RB 10_1101-2020_03_27_012757 285 12 so so IN 10_1101-2020_03_27_012757 285 13 that that IN 10_1101-2020_03_27_012757 285 14 researchers researcher NNS 10_1101-2020_03_27_012757 285 15 can can MD 10_1101-2020_03_27_012757 285 16 567 567 CD 10_1101-2020_03_27_012757 285 17 easily easily RB 10_1101-2020_03_27_012757 285 18 explore explore VB 10_1101-2020_03_27_012757 285 19 the the DT 10_1101-2020_03_27_012757 285 20 performance performance NN 10_1101-2020_03_27_012757 285 21 of of IN 10_1101-2020_03_27_012757 285 22 selected select VBN 10_1101-2020_03_27_012757 285 23 models model NNS 10_1101-2020_03_27_012757 285 24 or or CC 10_1101-2020_03_27_012757 285 25 identify identify VB 10_1101-2020_03_27_012757 285 26 the the DT 10_1101-2020_03_27_012757 285 27 best good JJS 10_1101-2020_03_27_012757 285 28 models model NNS 10_1101-2020_03_27_012757 285 29 for for IN 10_1101-2020_03_27_012757 285 30 any any DT 10_1101-2020_03_27_012757 285 31 of of IN 10_1101-2020_03_27_012757 285 32 the the DT 10_1101-2020_03_27_012757 285 33 22 22 CD 10_1101-2020_03_27_012757 285 34 568 568 CD 10_1101-2020_03_27_012757 285 35 general general JJ 10_1101-2020_03_27_012757 285 36 tumor tumor NN 10_1101-2020_03_27_012757 285 37 types type NNS 10_1101-2020_03_27_012757 285 38 and and CC 10_1101-2020_03_27_012757 285 39 the the DT 10_1101-2020_03_27_012757 285 40 36 36 CD 10_1101-2020_03_27_012757 285 41 subtypes subtype NNS 10_1101-2020_03_27_012757 285 42 presented present VBN 10_1101-2020_03_27_012757 285 43 here here RB 10_1101-2020_03_27_012757 285 44 . . . 10_1101-2020_03_27_012757 286 1 To to TO 10_1101-2020_03_27_012757 286 2 ensure ensure VB 10_1101-2020_03_27_012757 286 3 that that IN 10_1101-2020_03_27_012757 286 4 CCN CCN NNP 10_1101-2020_03_27_012757 286 5 is be VBZ 10_1101-2020_03_27_012757 286 6 widely widely RB 10_1101-2020_03_27_012757 286 7 569 569 CD 10_1101-2020_03_27_012757 286 8 available available JJ 10_1101-2020_03_27_012757 286 9 we -PRON- PRP 10_1101-2020_03_27_012757 286 10 have have VBP 10_1101-2020_03_27_012757 286 11 developed develop VBN 10_1101-2020_03_27_012757 286 12 a a DT 10_1101-2020_03_27_012757 286 13 free free JJ 10_1101-2020_03_27_012757 286 14 web web NN 10_1101-2020_03_27_012757 286 15 application application NN 10_1101-2020_03_27_012757 286 16 , , , 10_1101-2020_03_27_012757 286 17 which which WDT 10_1101-2020_03_27_012757 286 18 performs perform VBZ 10_1101-2020_03_27_012757 286 19 CCN CCN NNP 10_1101-2020_03_27_012757 286 20 analysis analysis NN 10_1101-2020_03_27_012757 286 21 on on IN 10_1101-2020_03_27_012757 286 22 user-570 user-570 NNP 10_1101-2020_03_27_012757 286 23 uploaded uploaded JJ 10_1101-2020_03_27_012757 286 24 data datum NNS 10_1101-2020_03_27_012757 286 25 and and CC 10_1101-2020_03_27_012757 286 26 allows allow VBZ 10_1101-2020_03_27_012757 286 27 for for IN 10_1101-2020_03_27_012757 286 28 direct direct JJ 10_1101-2020_03_27_012757 286 29 comparison comparison NN 10_1101-2020_03_27_012757 286 30 of of IN 10_1101-2020_03_27_012757 286 31 their -PRON- PRP$ 10_1101-2020_03_27_012757 286 32 data datum NNS 10_1101-2020_03_27_012757 286 33 to to IN 10_1101-2020_03_27_012757 286 34 the the DT 10_1101-2020_03_27_012757 286 35 cancer cancer NN 10_1101-2020_03_27_012757 286 36 models model NNS 10_1101-2020_03_27_012757 286 37 evaluated evaluate VBD 10_1101-2020_03_27_012757 286 38 571 571 CD 10_1101-2020_03_27_012757 286 39 here here RB 10_1101-2020_03_27_012757 286 40 . . . 10_1101-2020_03_27_012757 287 1 We -PRON- PRP 10_1101-2020_03_27_012757 287 2 have have VBP 10_1101-2020_03_27_012757 287 3 also also RB 10_1101-2020_03_27_012757 287 4 made make VBN 10_1101-2020_03_27_012757 287 5 the the DT 10_1101-2020_03_27_012757 287 6 CCN CCN NNP 10_1101-2020_03_27_012757 287 7 code code NN 10_1101-2020_03_27_012757 287 8 freely freely RB 10_1101-2020_03_27_012757 287 9 available available JJ 10_1101-2020_03_27_012757 287 10 under under IN 10_1101-2020_03_27_012757 287 11 an an DT 10_1101-2020_03_27_012757 287 12 Open open JJ 10_1101-2020_03_27_012757 287 13 Source source NN 10_1101-2020_03_27_012757 287 14 license license NN 10_1101-2020_03_27_012757 287 15 and and CC 10_1101-2020_03_27_012757 287 16 as as IN 10_1101-2020_03_27_012757 287 17 572 572 CD 10_1101-2020_03_27_012757 287 18 an an DT 10_1101-2020_03_27_012757 287 19 easily easily RB 10_1101-2020_03_27_012757 287 20 installed instal VBN 10_1101-2020_03_27_012757 287 21 R r NN 10_1101-2020_03_27_012757 287 22 package package NN 10_1101-2020_03_27_012757 287 23 , , , 10_1101-2020_03_27_012757 287 24 and and CC 10_1101-2020_03_27_012757 287 25 we -PRON- PRP 10_1101-2020_03_27_012757 287 26 are be VBP 10_1101-2020_03_27_012757 287 27 actively actively RB 10_1101-2020_03_27_012757 287 28 supporting support VBG 10_1101-2020_03_27_012757 287 29 its -PRON- PRP$ 10_1101-2020_03_27_012757 287 30 further further JJ 10_1101-2020_03_27_012757 287 31 development development NN 10_1101-2020_03_27_012757 287 32 . . . 10_1101-2020_03_27_012757 288 1 Included include VBN 10_1101-2020_03_27_012757 288 2 573 573 CD 10_1101-2020_03_27_012757 288 3 in in IN 10_1101-2020_03_27_012757 288 4 the the DT 10_1101-2020_03_27_012757 288 5 web web NN 10_1101-2020_03_27_012757 288 6 application application NN 10_1101-2020_03_27_012757 288 7 are be VBP 10_1101-2020_03_27_012757 288 8 instructions instruction NNS 10_1101-2020_03_27_012757 288 9 for for IN 10_1101-2020_03_27_012757 288 10 training train VBG 10_1101-2020_03_27_012757 288 11 CCN CCN NNP 10_1101-2020_03_27_012757 288 12 and and CC 10_1101-2020_03_27_012757 288 13 reproducing reproduce VBG 10_1101-2020_03_27_012757 288 14 our -PRON- PRP$ 10_1101-2020_03_27_012757 288 15 analysis analysis NN 10_1101-2020_03_27_012757 288 16 . . . 10_1101-2020_03_27_012757 289 1 The the DT 10_1101-2020_03_27_012757 289 2 574 574 CD 10_1101-2020_03_27_012757 289 3 documentation documentation NN 10_1101-2020_03_27_012757 289 4 describes describe VBZ 10_1101-2020_03_27_012757 289 5 how how WRB 10_1101-2020_03_27_012757 289 6 to to TO 10_1101-2020_03_27_012757 289 7 analyze analyze VB 10_1101-2020_03_27_012757 289 8 models model NNS 10_1101-2020_03_27_012757 289 9 and and CC 10_1101-2020_03_27_012757 289 10 compare compare VB 10_1101-2020_03_27_012757 289 11 the the DT 10_1101-2020_03_27_012757 289 12 results result NNS 10_1101-2020_03_27_012757 289 13 to to IN 10_1101-2020_03_27_012757 289 14 the the DT 10_1101-2020_03_27_012757 289 15 panel panel NN 10_1101-2020_03_27_012757 289 16 of of IN 10_1101-2020_03_27_012757 289 17 575 575 CD 10_1101-2020_03_27_012757 289 18 models model NNS 10_1101-2020_03_27_012757 289 19 that that WDT 10_1101-2020_03_27_012757 289 20 we -PRON- PRP 10_1101-2020_03_27_012757 289 21 evaluated evaluate VBD 10_1101-2020_03_27_012757 289 22 here here RB 10_1101-2020_03_27_012757 289 23 , , , 10_1101-2020_03_27_012757 289 24 thereby thereby RB 10_1101-2020_03_27_012757 289 25 allowing allow VBG 10_1101-2020_03_27_012757 289 26 researchers researcher NNS 10_1101-2020_03_27_012757 289 27 to to TO 10_1101-2020_03_27_012757 289 28 immediately immediately RB 10_1101-2020_03_27_012757 289 29 compare compare VB 10_1101-2020_03_27_012757 289 30 their -PRON- PRP$ 10_1101-2020_03_27_012757 289 31 576 576 CD 10_1101-2020_03_27_012757 289 32 models model NNS 10_1101-2020_03_27_012757 289 33 to to IN 10_1101-2020_03_27_012757 289 34 the the DT 10_1101-2020_03_27_012757 289 35 broader broad JJR 10_1101-2020_03_27_012757 289 36 field field NN 10_1101-2020_03_27_012757 289 37 in in IN 10_1101-2020_03_27_012757 289 38 a a DT 10_1101-2020_03_27_012757 289 39 comprehensive comprehensive JJ 10_1101-2020_03_27_012757 289 40 and and CC 10_1101-2020_03_27_012757 289 41 standard standard JJ 10_1101-2020_03_27_012757 289 42 fashion fashion NN 10_1101-2020_03_27_012757 289 43 . . . 10_1101-2020_03_27_012757 290 1 577 577 CD 10_1101-2020_03_27_012757 290 2 .CC .CC NFP 10_1101-2020_03_27_012757 290 3 - - : 10_1101-2020_03_27_012757 290 4 BY by IN 10_1101-2020_03_27_012757 290 5 - - HYPH 10_1101-2020_03_27_012757 290 6 NC NC NNP 10_1101-2020_03_27_012757 290 7 - - HYPH 10_1101-2020_03_27_012757 290 8 ND ND NNP 10_1101-2020_03_27_012757 290 9 4.0 4.0 CD 10_1101-2020_03_27_012757 290 10 International International NNP 10_1101-2020_03_27_012757 290 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 290 12 under under IN 10_1101-2020_03_27_012757 290 13 a a DT 10_1101-2020_03_27_012757 290 14 ( ( -LRB- 10_1101-2020_03_27_012757 290 15 which which WDT 10_1101-2020_03_27_012757 290 16 was be VBD 10_1101-2020_03_27_012757 290 17 not not RB 10_1101-2020_03_27_012757 290 18 certified certify VBN 10_1101-2020_03_27_012757 290 19 by by IN 10_1101-2020_03_27_012757 290 20 peer peer NN 10_1101-2020_03_27_012757 290 21 review review NN 10_1101-2020_03_27_012757 290 22 ) ) -RRB- 10_1101-2020_03_27_012757 290 23 is be VBZ 10_1101-2020_03_27_012757 290 24 the the DT 10_1101-2020_03_27_012757 290 25 author author NN 10_1101-2020_03_27_012757 290 26 / / SYM 10_1101-2020_03_27_012757 290 27 funder funder NN 10_1101-2020_03_27_012757 290 28 , , , 10_1101-2020_03_27_012757 290 29 who who WP 10_1101-2020_03_27_012757 290 30 has have VBZ 10_1101-2020_03_27_012757 290 31 granted grant VBN 10_1101-2020_03_27_012757 290 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 290 33 a a DT 10_1101-2020_03_27_012757 290 34 license license NN 10_1101-2020_03_27_012757 290 35 to to TO 10_1101-2020_03_27_012757 290 36 display display VB 10_1101-2020_03_27_012757 290 37 the the DT 10_1101-2020_03_27_012757 290 38 preprint preprint NN 10_1101-2020_03_27_012757 290 39 in in IN 10_1101-2020_03_27_012757 290 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 290 41 . . . 10_1101-2020_03_27_012757 291 1 It -PRON- PRP 10_1101-2020_03_27_012757 291 2 is be VBZ 10_1101-2020_03_27_012757 291 3 made make VBN 10_1101-2020_03_27_012757 291 4 The the DT 10_1101-2020_03_27_012757 291 5 copyright copyright NN 10_1101-2020_03_27_012757 291 6 holder holder NN 10_1101-2020_03_27_012757 291 7 for for IN 10_1101-2020_03_27_012757 291 8 this this DT 10_1101-2020_03_27_012757 291 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 291 10 version version NN 10_1101-2020_03_27_012757 291 11 posted post VBD 10_1101-2020_03_27_012757 291 12 January January NNP 10_1101-2020_03_27_012757 291 13 9 9 CD 10_1101-2020_03_27_012757 291 14 , , , 10_1101-2020_03_27_012757 291 15 2021 2021 CD 10_1101-2020_03_27_012757 291 16 . . . 10_1101-2020_03_27_012757 291 17 ; ; : 10_1101-2020_03_27_012757 291 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 291 19 : : : 10_1101-2020_03_27_012757 291 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 291 21 preprint preprint NN 10_1101-2020_03_27_012757 291 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 291 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 291 24 22 22 CD 10_1101-2020_03_27_012757 291 25 578 578 CD 10_1101-2020_03_27_012757 291 26 Online Online NNP 10_1101-2020_03_27_012757 291 27 Methods Methods NNP 10_1101-2020_03_27_012757 291 28 579 579 CD 10_1101-2020_03_27_012757 291 29 Training Training NNP 10_1101-2020_03_27_012757 291 30 General General NNP 10_1101-2020_03_27_012757 291 31 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 291 32 Classifier Classifier NNP 10_1101-2020_03_27_012757 291 33 580 580 CD 10_1101-2020_03_27_012757 291 34 To to TO 10_1101-2020_03_27_012757 291 35 generate generate VB 10_1101-2020_03_27_012757 291 36 training training NN 10_1101-2020_03_27_012757 291 37 data data NN 10_1101-2020_03_27_012757 291 38 sets set NNS 10_1101-2020_03_27_012757 291 39 , , , 10_1101-2020_03_27_012757 291 40 we -PRON- PRP 10_1101-2020_03_27_012757 291 41 downloaded download VBD 10_1101-2020_03_27_012757 291 42 8,991 8,991 CD 10_1101-2020_03_27_012757 291 43 patient patient JJ 10_1101-2020_03_27_012757 291 44 tumor tumor NN 10_1101-2020_03_27_012757 291 45 RNA RNA NNP 10_1101-2020_03_27_012757 291 46 - - HYPH 10_1101-2020_03_27_012757 291 47 seq seq NN 10_1101-2020_03_27_012757 291 48 expression expression NN 10_1101-2020_03_27_012757 291 49 581 581 CD 10_1101-2020_03_27_012757 291 50 count count NN 10_1101-2020_03_27_012757 291 51 matrix matrix NN 10_1101-2020_03_27_012757 291 52 and and CC 10_1101-2020_03_27_012757 291 53 their -PRON- PRP$ 10_1101-2020_03_27_012757 291 54 corresponding corresponding JJ 10_1101-2020_03_27_012757 291 55 sample sample NN 10_1101-2020_03_27_012757 291 56 table table NN 10_1101-2020_03_27_012757 291 57 across across IN 10_1101-2020_03_27_012757 291 58 22 22 CD 10_1101-2020_03_27_012757 291 59 different different JJ 10_1101-2020_03_27_012757 291 60 tumor tumor NN 10_1101-2020_03_27_012757 291 61 types type NNS 10_1101-2020_03_27_012757 291 62 from from IN 10_1101-2020_03_27_012757 291 63 TCGA TCGA NNP 10_1101-2020_03_27_012757 291 64 582 582 CD 10_1101-2020_03_27_012757 291 65 using use VBG 10_1101-2020_03_27_012757 291 66 TCGAWorkflowData TCGAWorkflowData NNP 10_1101-2020_03_27_012757 291 67 , , , 10_1101-2020_03_27_012757 291 68 TCGAbiolinks85 tcgabiolinks85 NN 10_1101-2020_03_27_012757 291 69 and and CC 10_1101-2020_03_27_012757 291 70 SummarizedExperiment86 summarizedexperiment86 NN 10_1101-2020_03_27_012757 291 71 packages package NNS 10_1101-2020_03_27_012757 291 72 . . . 10_1101-2020_03_27_012757 292 1 We -PRON- PRP 10_1101-2020_03_27_012757 292 2 used use VBD 10_1101-2020_03_27_012757 292 3 583 583 CD 10_1101-2020_03_27_012757 292 4 all all PDT 10_1101-2020_03_27_012757 292 5 the the DT 10_1101-2020_03_27_012757 292 6 patient patient JJ 10_1101-2020_03_27_012757 292 7 tumor tumor NN 10_1101-2020_03_27_012757 292 8 samples sample NNS 10_1101-2020_03_27_012757 292 9 for for IN 10_1101-2020_03_27_012757 292 10 training train VBG 10_1101-2020_03_27_012757 292 11 the the DT 10_1101-2020_03_27_012757 292 12 general general JJ 10_1101-2020_03_27_012757 292 13 CCN CCN NNP 10_1101-2020_03_27_012757 292 14 classifier classifier NN 10_1101-2020_03_27_012757 292 15 . . . 10_1101-2020_03_27_012757 293 1 We -PRON- PRP 10_1101-2020_03_27_012757 293 2 limited limit VBD 10_1101-2020_03_27_012757 293 3 training training NN 10_1101-2020_03_27_012757 293 4 and and CC 10_1101-2020_03_27_012757 293 5 584 584 CD 10_1101-2020_03_27_012757 293 6 analysis analysis NN 10_1101-2020_03_27_012757 293 7 of of IN 10_1101-2020_03_27_012757 293 8 RNA RNA NNP 10_1101-2020_03_27_012757 293 9 - - HYPH 10_1101-2020_03_27_012757 293 10 seq seq NN 10_1101-2020_03_27_012757 293 11 data datum NNS 10_1101-2020_03_27_012757 293 12 to to IN 10_1101-2020_03_27_012757 293 13 the the DT 10_1101-2020_03_27_012757 293 14 13,142 13,142 CD 10_1101-2020_03_27_012757 293 15 genes gene NNS 10_1101-2020_03_27_012757 293 16 in in IN 10_1101-2020_03_27_012757 293 17 common common JJ 10_1101-2020_03_27_012757 293 18 between between IN 10_1101-2020_03_27_012757 293 19 the the DT 10_1101-2020_03_27_012757 293 20 TCGA TCGA NNP 10_1101-2020_03_27_012757 293 21 dataset dataset NN 10_1101-2020_03_27_012757 293 22 and and CC 10_1101-2020_03_27_012757 293 23 all all DT 10_1101-2020_03_27_012757 293 24 585 585 CD 10_1101-2020_03_27_012757 293 25 the the DT 10_1101-2020_03_27_012757 293 26 query query NN 10_1101-2020_03_27_012757 293 27 samples sample NNS 10_1101-2020_03_27_012757 293 28 ( ( -LRB- 10_1101-2020_03_27_012757 293 29 CCLs ccl NNS 10_1101-2020_03_27_012757 293 30 , , , 10_1101-2020_03_27_012757 293 31 PDXs pdx NNS 10_1101-2020_03_27_012757 293 32 , , , 10_1101-2020_03_27_012757 293 33 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 293 34 , , , 10_1101-2020_03_27_012757 293 35 and and CC 10_1101-2020_03_27_012757 293 36 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 293 37 ) ) -RRB- 10_1101-2020_03_27_012757 293 38 . . . 10_1101-2020_03_27_012757 294 1 To to TO 10_1101-2020_03_27_012757 294 2 train train VB 10_1101-2020_03_27_012757 294 3 the the DT 10_1101-2020_03_27_012757 294 4 top top JJ 10_1101-2020_03_27_012757 294 5 pair pair NN 10_1101-2020_03_27_012757 294 6 Random Random NNP 10_1101-2020_03_27_012757 294 7 forest forest NN 10_1101-2020_03_27_012757 294 8 586 586 CD 10_1101-2020_03_27_012757 294 9 classifier classifier NN 10_1101-2020_03_27_012757 294 10 , , , 10_1101-2020_03_27_012757 294 11 we -PRON- PRP 10_1101-2020_03_27_012757 294 12 used use VBD 10_1101-2020_03_27_012757 294 13 a a DT 10_1101-2020_03_27_012757 294 14 method method NN 10_1101-2020_03_27_012757 294 15 similar similar JJ 10_1101-2020_03_27_012757 294 16 to to IN 10_1101-2020_03_27_012757 294 17 our -PRON- PRP$ 10_1101-2020_03_27_012757 294 18 previous previous JJ 10_1101-2020_03_27_012757 294 19 method23 method23 NN 10_1101-2020_03_27_012757 294 20 . . . 10_1101-2020_03_27_012757 295 1 CCN CCN NNP 10_1101-2020_03_27_012757 295 2 first first RB 10_1101-2020_03_27_012757 295 3 normalized normalize VBD 10_1101-2020_03_27_012757 295 4 the the DT 10_1101-2020_03_27_012757 295 5 training training NN 10_1101-2020_03_27_012757 295 6 587 587 CD 10_1101-2020_03_27_012757 295 7 counts count NNS 10_1101-2020_03_27_012757 295 8 matrix matrix NN 10_1101-2020_03_27_012757 295 9 by by IN 10_1101-2020_03_27_012757 295 10 down down RB 10_1101-2020_03_27_012757 295 11 - - HYPH 10_1101-2020_03_27_012757 295 12 sampling sample VBG 10_1101-2020_03_27_012757 295 13 the the DT 10_1101-2020_03_27_012757 295 14 counts count NNS 10_1101-2020_03_27_012757 295 15 to to IN 10_1101-2020_03_27_012757 295 16 500,000 500,000 CD 10_1101-2020_03_27_012757 295 17 counts count NNS 10_1101-2020_03_27_012757 295 18 per per IN 10_1101-2020_03_27_012757 295 19 sample sample NN 10_1101-2020_03_27_012757 295 20 . . . 10_1101-2020_03_27_012757 296 1 To to IN 10_1101-2020_03_27_012757 296 2 significantly significantly RB 10_1101-2020_03_27_012757 296 3 588 588 CD 10_1101-2020_03_27_012757 296 4 reduce reduce VB 10_1101-2020_03_27_012757 296 5 the the DT 10_1101-2020_03_27_012757 296 6 execution execution NN 10_1101-2020_03_27_012757 296 7 time time NN 10_1101-2020_03_27_012757 296 8 and and CC 10_1101-2020_03_27_012757 296 9 memory memory NN 10_1101-2020_03_27_012757 296 10 of of IN 10_1101-2020_03_27_012757 296 11 generating generate VBG 10_1101-2020_03_27_012757 296 12 gene gene NN 10_1101-2020_03_27_012757 296 13 pairs pair NNS 10_1101-2020_03_27_012757 296 14 for for IN 10_1101-2020_03_27_012757 296 15 all all DT 10_1101-2020_03_27_012757 296 16 possible possible JJ 10_1101-2020_03_27_012757 296 17 genes gene NNS 10_1101-2020_03_27_012757 296 18 , , , 10_1101-2020_03_27_012757 296 19 CCN CCN NNP 10_1101-2020_03_27_012757 296 20 589 589 CD 10_1101-2020_03_27_012757 296 21 then then RB 10_1101-2020_03_27_012757 296 22 selected select VBD 10_1101-2020_03_27_012757 296 23 n n CC 10_1101-2020_03_27_012757 296 24 up up RB 10_1101-2020_03_27_012757 296 25 - - HYPH 10_1101-2020_03_27_012757 296 26 regulated regulated JJ 10_1101-2020_03_27_012757 296 27 genes gene NNS 10_1101-2020_03_27_012757 296 28 , , , 10_1101-2020_03_27_012757 296 29 n n CC 10_1101-2020_03_27_012757 296 30 down down RB 10_1101-2020_03_27_012757 296 31 - - HYPH 10_1101-2020_03_27_012757 296 32 regulated regulated JJ 10_1101-2020_03_27_012757 296 33 genes gene NNS 10_1101-2020_03_27_012757 296 34 and and CC 10_1101-2020_03_27_012757 296 35 n n RB 10_1101-2020_03_27_012757 296 36 least least JJS 10_1101-2020_03_27_012757 296 37 differentially differentially RB 10_1101-2020_03_27_012757 296 38 590 590 CD 10_1101-2020_03_27_012757 296 39 expressed express VBN 10_1101-2020_03_27_012757 296 40 genes gene NNS 10_1101-2020_03_27_012757 296 41 ( ( -LRB- 10_1101-2020_03_27_012757 296 42 CCN CCN NNP 10_1101-2020_03_27_012757 296 43 training train VBG 10_1101-2020_03_27_012757 296 44 parameter parameter NN 10_1101-2020_03_27_012757 296 45 nTopGenes nTopGenes NNP 10_1101-2020_03_27_012757 296 46 = = SYM 10_1101-2020_03_27_012757 296 47 n n NN 10_1101-2020_03_27_012757 296 48 ) ) -RRB- 10_1101-2020_03_27_012757 296 49 for for IN 10_1101-2020_03_27_012757 296 50 each each DT 10_1101-2020_03_27_012757 296 51 of of IN 10_1101-2020_03_27_012757 296 52 the the DT 10_1101-2020_03_27_012757 296 53 22 22 CD 10_1101-2020_03_27_012757 296 54 cancer cancer NN 10_1101-2020_03_27_012757 296 55 591 591 CD 10_1101-2020_03_27_012757 296 56 categories category NNS 10_1101-2020_03_27_012757 296 57 using use VBG 10_1101-2020_03_27_012757 296 58 template template NN 10_1101-2020_03_27_012757 296 59 matching87 matching87 NNP 10_1101-2020_03_27_012757 296 60 as as IN 10_1101-2020_03_27_012757 296 61 the the DT 10_1101-2020_03_27_012757 296 62 genes gene NNS 10_1101-2020_03_27_012757 296 63 to to TO 10_1101-2020_03_27_012757 296 64 generate generate VB 10_1101-2020_03_27_012757 296 65 top top JJ 10_1101-2020_03_27_012757 296 66 scoring score VBG 10_1101-2020_03_27_012757 296 67 gene gene NN 10_1101-2020_03_27_012757 296 68 pairs pair NNS 10_1101-2020_03_27_012757 296 69 . . . 10_1101-2020_03_27_012757 297 1 In in IN 10_1101-2020_03_27_012757 297 2 short short JJ 10_1101-2020_03_27_012757 297 3 , , , 10_1101-2020_03_27_012757 297 4 592 592 CD 10_1101-2020_03_27_012757 297 5 for for IN 10_1101-2020_03_27_012757 297 6 each each DT 10_1101-2020_03_27_012757 297 7 tumor tumor NN 10_1101-2020_03_27_012757 297 8 type type NN 10_1101-2020_03_27_012757 297 9 , , , 10_1101-2020_03_27_012757 297 10 CCN CCN NNP 10_1101-2020_03_27_012757 297 11 defined define VBD 10_1101-2020_03_27_012757 297 12 a a DT 10_1101-2020_03_27_012757 297 13 template template NN 10_1101-2020_03_27_012757 297 14 vector vector NN 10_1101-2020_03_27_012757 297 15 that that WDT 10_1101-2020_03_27_012757 297 16 labelled label VBD 10_1101-2020_03_27_012757 297 17 the the DT 10_1101-2020_03_27_012757 297 18 training training NN 10_1101-2020_03_27_012757 297 19 tumor tumor NN 10_1101-2020_03_27_012757 297 20 samples sample NNS 10_1101-2020_03_27_012757 297 21 in in IN 10_1101-2020_03_27_012757 297 22 593 593 CD 10_1101-2020_03_27_012757 297 23 cancer cancer NN 10_1101-2020_03_27_012757 297 24 type type NN 10_1101-2020_03_27_012757 297 25 of of IN 10_1101-2020_03_27_012757 297 26 interest interest NN 10_1101-2020_03_27_012757 297 27 as as IN 10_1101-2020_03_27_012757 297 28 1 1 CD 10_1101-2020_03_27_012757 297 29 and and CC 10_1101-2020_03_27_012757 297 30 all all DT 10_1101-2020_03_27_012757 297 31 other other JJ 10_1101-2020_03_27_012757 297 32 tumor tumor NN 10_1101-2020_03_27_012757 297 33 samples sample NNS 10_1101-2020_03_27_012757 297 34 as as IN 10_1101-2020_03_27_012757 297 35 0 0 CD 10_1101-2020_03_27_012757 297 36 CCN CCN NNP 10_1101-2020_03_27_012757 297 37 then then RB 10_1101-2020_03_27_012757 297 38 calculated calculate VBD 10_1101-2020_03_27_012757 297 39 the the DT 10_1101-2020_03_27_012757 297 40 Pearson Pearson NNP 10_1101-2020_03_27_012757 297 41 594 594 CD 10_1101-2020_03_27_012757 297 42 correlation correlation NN 10_1101-2020_03_27_012757 297 43 coefficient coefficient NN 10_1101-2020_03_27_012757 297 44 between between IN 10_1101-2020_03_27_012757 297 45 template template NN 10_1101-2020_03_27_012757 297 46 vector vector NN 10_1101-2020_03_27_012757 297 47 and and CC 10_1101-2020_03_27_012757 297 48 gene gene NN 10_1101-2020_03_27_012757 297 49 expressions expression NNS 10_1101-2020_03_27_012757 297 50 for for IN 10_1101-2020_03_27_012757 297 51 all all DT 10_1101-2020_03_27_012757 297 52 genes gene NNS 10_1101-2020_03_27_012757 297 53 . . . 10_1101-2020_03_27_012757 298 1 The the DT 10_1101-2020_03_27_012757 298 2 genes gene NNS 10_1101-2020_03_27_012757 298 3 595 595 CD 10_1101-2020_03_27_012757 298 4 with with IN 10_1101-2020_03_27_012757 298 5 strong strong JJ 10_1101-2020_03_27_012757 298 6 match match NN 10_1101-2020_03_27_012757 298 7 to to TO 10_1101-2020_03_27_012757 298 8 template template VB 10_1101-2020_03_27_012757 298 9 as as IN 10_1101-2020_03_27_012757 298 10 either either CC 10_1101-2020_03_27_012757 298 11 upregulated upregulate VBN 10_1101-2020_03_27_012757 298 12 or or CC 10_1101-2020_03_27_012757 298 13 downregulated downregulated JJ 10_1101-2020_03_27_012757 298 14 had have VBD 10_1101-2020_03_27_012757 298 15 large large JJ 10_1101-2020_03_27_012757 298 16 absolute absolute JJ 10_1101-2020_03_27_012757 298 17 596 596 CD 10_1101-2020_03_27_012757 298 18 Pearson Pearson NNP 10_1101-2020_03_27_012757 298 19 correlation correlation NN 10_1101-2020_03_27_012757 298 20 coefficient coefficient NN 10_1101-2020_03_27_012757 298 21 . . . 10_1101-2020_03_27_012757 299 1 CCN CCN NNP 10_1101-2020_03_27_012757 299 2 chose choose VBD 10_1101-2020_03_27_012757 299 3 the the DT 10_1101-2020_03_27_012757 299 4 upregulated upregulated JJ 10_1101-2020_03_27_012757 299 5 , , , 10_1101-2020_03_27_012757 299 6 downregulated downregulated JJ 10_1101-2020_03_27_012757 299 7 and and CC 10_1101-2020_03_27_012757 299 8 least least JJS 10_1101-2020_03_27_012757 299 9 597 597 CD 10_1101-2020_03_27_012757 299 10 differentially differentially RB 10_1101-2020_03_27_012757 299 11 expressed express VBN 10_1101-2020_03_27_012757 299 12 genes gene NNS 10_1101-2020_03_27_012757 299 13 based base VBN 10_1101-2020_03_27_012757 299 14 on on IN 10_1101-2020_03_27_012757 299 15 the the DT 10_1101-2020_03_27_012757 299 16 magnitude magnitude NN 10_1101-2020_03_27_012757 299 17 of of IN 10_1101-2020_03_27_012757 299 18 Pearson Pearson NNP 10_1101-2020_03_27_012757 299 19 correlation correlation NN 10_1101-2020_03_27_012757 299 20 coefficient coefficient NN 10_1101-2020_03_27_012757 299 21 . . . 10_1101-2020_03_27_012757 300 1 598 598 CD 10_1101-2020_03_27_012757 300 2 After after IN 10_1101-2020_03_27_012757 300 3 CCN CCN NNP 10_1101-2020_03_27_012757 300 4 selected select VBD 10_1101-2020_03_27_012757 300 5 the the DT 10_1101-2020_03_27_012757 300 6 genes gene NNS 10_1101-2020_03_27_012757 300 7 for for IN 10_1101-2020_03_27_012757 300 8 each each DT 10_1101-2020_03_27_012757 300 9 cancer cancer NN 10_1101-2020_03_27_012757 300 10 type type NN 10_1101-2020_03_27_012757 300 11 , , , 10_1101-2020_03_27_012757 300 12 CCN CCN NNP 10_1101-2020_03_27_012757 300 13 generated generate VBD 10_1101-2020_03_27_012757 300 14 gene gene NN 10_1101-2020_03_27_012757 300 15 pairs pair NNS 10_1101-2020_03_27_012757 300 16 among among IN 10_1101-2020_03_27_012757 300 17 599 599 CD 10_1101-2020_03_27_012757 300 18 those those DT 10_1101-2020_03_27_012757 300 19 genes gene NNS 10_1101-2020_03_27_012757 300 20 . . . 10_1101-2020_03_27_012757 301 1 Gene gene NN 10_1101-2020_03_27_012757 301 2 pair pair NN 10_1101-2020_03_27_012757 301 3 transformation transformation NN 10_1101-2020_03_27_012757 301 4 was be VBD 10_1101-2020_03_27_012757 301 5 a a DT 10_1101-2020_03_27_012757 301 6 method method NN 10_1101-2020_03_27_012757 301 7 inspired inspire VBN 10_1101-2020_03_27_012757 301 8 by by IN 10_1101-2020_03_27_012757 301 9 the the DT 10_1101-2020_03_27_012757 301 10 top top RB 10_1101-2020_03_27_012757 301 11 - - HYPH 10_1101-2020_03_27_012757 301 12 scoring score VBG 10_1101-2020_03_27_012757 301 13 pair pair NN 10_1101-2020_03_27_012757 301 14 classifier88 classifier88 NNP 10_1101-2020_03_27_012757 301 15 600 600 CD 10_1101-2020_03_27_012757 301 16 to to TO 10_1101-2020_03_27_012757 301 17 allow allow VB 10_1101-2020_03_27_012757 301 18 compatibility compatibility NN 10_1101-2020_03_27_012757 301 19 of of IN 10_1101-2020_03_27_012757 301 20 classifier classifier NN 10_1101-2020_03_27_012757 301 21 with with IN 10_1101-2020_03_27_012757 301 22 query query NNP 10_1101-2020_03_27_012757 301 23 expression expression NN 10_1101-2020_03_27_012757 301 24 profiles profile NNS 10_1101-2020_03_27_012757 301 25 that that WDT 10_1101-2020_03_27_012757 301 26 were be VBD 10_1101-2020_03_27_012757 301 27 collected collect VBN 10_1101-2020_03_27_012757 301 28 through through IN 10_1101-2020_03_27_012757 301 29 601 601 CD 10_1101-2020_03_27_012757 301 30 different different JJ 10_1101-2020_03_27_012757 301 31 platforms platform NNS 10_1101-2020_03_27_012757 301 32 ( ( -LRB- 10_1101-2020_03_27_012757 301 33 e.g. e.g. RB 10_1101-2020_03_27_012757 302 1 microarray microarray JJ 10_1101-2020_03_27_012757 302 2 query query NNP 10_1101-2020_03_27_012757 302 3 data datum NNS 10_1101-2020_03_27_012757 302 4 applied apply VBN 10_1101-2020_03_27_012757 302 5 to to IN 10_1101-2020_03_27_012757 302 6 RNA RNA NNP 10_1101-2020_03_27_012757 302 7 - - HYPH 10_1101-2020_03_27_012757 302 8 seq seq NN 10_1101-2020_03_27_012757 302 9 training training NN 10_1101-2020_03_27_012757 302 10 data datum NNS 10_1101-2020_03_27_012757 302 11 ) ) -RRB- 10_1101-2020_03_27_012757 302 12 . . . 10_1101-2020_03_27_012757 303 1 In in IN 10_1101-2020_03_27_012757 303 2 brief brief NN 10_1101-2020_03_27_012757 303 3 , , , 10_1101-2020_03_27_012757 303 4 the the DT 10_1101-2020_03_27_012757 303 5 602 602 CD 10_1101-2020_03_27_012757 303 6 gene gene NN 10_1101-2020_03_27_012757 303 7 pair pair NN 10_1101-2020_03_27_012757 303 8 transformation transformation NN 10_1101-2020_03_27_012757 303 9 compares compare VBZ 10_1101-2020_03_27_012757 303 10 2 2 CD 10_1101-2020_03_27_012757 303 11 genes gene NNS 10_1101-2020_03_27_012757 303 12 within within IN 10_1101-2020_03_27_012757 303 13 an an DT 10_1101-2020_03_27_012757 303 14 expression expression NN 10_1101-2020_03_27_012757 303 15 sample sample NN 10_1101-2020_03_27_012757 303 16 and and CC 10_1101-2020_03_27_012757 303 17 encodes encode VBZ 10_1101-2020_03_27_012757 303 18 the the DT 10_1101-2020_03_27_012757 303 19 603 603 CD 10_1101-2020_03_27_012757 303 20 .CC .CC : 10_1101-2020_03_27_012757 303 21 - - HYPH 10_1101-2020_03_27_012757 303 22 BY by IN 10_1101-2020_03_27_012757 303 23 - - HYPH 10_1101-2020_03_27_012757 303 24 NC NC NNP 10_1101-2020_03_27_012757 303 25 - - HYPH 10_1101-2020_03_27_012757 303 26 ND ND NNP 10_1101-2020_03_27_012757 303 27 4.0 4.0 CD 10_1101-2020_03_27_012757 303 28 International International NNP 10_1101-2020_03_27_012757 303 29 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 303 30 under under IN 10_1101-2020_03_27_012757 303 31 a a DT 10_1101-2020_03_27_012757 303 32 ( ( -LRB- 10_1101-2020_03_27_012757 303 33 which which WDT 10_1101-2020_03_27_012757 303 34 was be VBD 10_1101-2020_03_27_012757 303 35 not not RB 10_1101-2020_03_27_012757 303 36 certified certify VBN 10_1101-2020_03_27_012757 303 37 by by IN 10_1101-2020_03_27_012757 303 38 peer peer NN 10_1101-2020_03_27_012757 303 39 review review NN 10_1101-2020_03_27_012757 303 40 ) ) -RRB- 10_1101-2020_03_27_012757 303 41 is be VBZ 10_1101-2020_03_27_012757 303 42 the the DT 10_1101-2020_03_27_012757 303 43 author author NN 10_1101-2020_03_27_012757 303 44 / / SYM 10_1101-2020_03_27_012757 303 45 funder funder NN 10_1101-2020_03_27_012757 303 46 , , , 10_1101-2020_03_27_012757 303 47 who who WP 10_1101-2020_03_27_012757 303 48 has have VBZ 10_1101-2020_03_27_012757 303 49 granted grant VBN 10_1101-2020_03_27_012757 303 50 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 303 51 a a DT 10_1101-2020_03_27_012757 303 52 license license NN 10_1101-2020_03_27_012757 303 53 to to TO 10_1101-2020_03_27_012757 303 54 display display VB 10_1101-2020_03_27_012757 303 55 the the DT 10_1101-2020_03_27_012757 303 56 preprint preprint NN 10_1101-2020_03_27_012757 303 57 in in IN 10_1101-2020_03_27_012757 303 58 perpetuity perpetuity NN 10_1101-2020_03_27_012757 303 59 . . . 10_1101-2020_03_27_012757 304 1 It -PRON- PRP 10_1101-2020_03_27_012757 304 2 is be VBZ 10_1101-2020_03_27_012757 304 3 made make VBN 10_1101-2020_03_27_012757 304 4 The the DT 10_1101-2020_03_27_012757 304 5 copyright copyright NN 10_1101-2020_03_27_012757 304 6 holder holder NN 10_1101-2020_03_27_012757 304 7 for for IN 10_1101-2020_03_27_012757 304 8 this this DT 10_1101-2020_03_27_012757 304 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 304 10 version version NN 10_1101-2020_03_27_012757 304 11 posted post VBD 10_1101-2020_03_27_012757 304 12 January January NNP 10_1101-2020_03_27_012757 304 13 9 9 CD 10_1101-2020_03_27_012757 304 14 , , , 10_1101-2020_03_27_012757 304 15 2021 2021 CD 10_1101-2020_03_27_012757 304 16 . . . 10_1101-2020_03_27_012757 304 17 ; ; : 10_1101-2020_03_27_012757 304 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 304 19 : : : 10_1101-2020_03_27_012757 304 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 304 21 preprint preprint NN 10_1101-2020_03_27_012757 304 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 304 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 304 24 23 23 CD 10_1101-2020_03_27_012757 304 25 “ " `` 10_1101-2020_03_27_012757 304 26 gene1_gene2 gene1_gene2 NNP 10_1101-2020_03_27_012757 304 27 ” " '' 10_1101-2020_03_27_012757 304 28 gene gene NN 10_1101-2020_03_27_012757 304 29 - - HYPH 10_1101-2020_03_27_012757 304 30 pair pair NN 10_1101-2020_03_27_012757 304 31 as as IN 10_1101-2020_03_27_012757 304 32 1 1 CD 10_1101-2020_03_27_012757 304 33 if if IN 10_1101-2020_03_27_012757 304 34 the the DT 10_1101-2020_03_27_012757 304 35 first first JJ 10_1101-2020_03_27_012757 304 36 gene gene NN 10_1101-2020_03_27_012757 304 37 has have VBZ 10_1101-2020_03_27_012757 304 38 higher high JJR 10_1101-2020_03_27_012757 304 39 expression expression NN 10_1101-2020_03_27_012757 304 40 than than IN 10_1101-2020_03_27_012757 304 41 the the DT 10_1101-2020_03_27_012757 304 42 second second JJ 10_1101-2020_03_27_012757 304 43 gene gene NN 10_1101-2020_03_27_012757 304 44 . . . 10_1101-2020_03_27_012757 305 1 604 604 CD 10_1101-2020_03_27_012757 305 2 Otherwise otherwise RB 10_1101-2020_03_27_012757 305 3 , , , 10_1101-2020_03_27_012757 305 4 gene gene NN 10_1101-2020_03_27_012757 305 5 pair pair NN 10_1101-2020_03_27_012757 305 6 transformation transformation NN 10_1101-2020_03_27_012757 305 7 would would MD 10_1101-2020_03_27_012757 305 8 encode encode VB 10_1101-2020_03_27_012757 305 9 the the DT 10_1101-2020_03_27_012757 305 10 gene gene NN 10_1101-2020_03_27_012757 305 11 - - HYPH 10_1101-2020_03_27_012757 305 12 pair pair NN 10_1101-2020_03_27_012757 305 13 as as IN 10_1101-2020_03_27_012757 305 14 0 0 CD 10_1101-2020_03_27_012757 305 15 . . . 10_1101-2020_03_27_012757 306 1 Using use VBG 10_1101-2020_03_27_012757 306 2 all all PDT 10_1101-2020_03_27_012757 306 3 the the DT 10_1101-2020_03_27_012757 306 4 gene gene NN 10_1101-2020_03_27_012757 306 5 pair pair NN 10_1101-2020_03_27_012757 306 6 605 605 CD 10_1101-2020_03_27_012757 306 7 combinations combination NNS 10_1101-2020_03_27_012757 306 8 generated generate VBN 10_1101-2020_03_27_012757 306 9 through through IN 10_1101-2020_03_27_012757 306 10 the the DT 10_1101-2020_03_27_012757 306 11 gene gene NN 10_1101-2020_03_27_012757 306 12 sets set NNS 10_1101-2020_03_27_012757 306 13 per per IN 10_1101-2020_03_27_012757 306 14 cancer cancer NN 10_1101-2020_03_27_012757 306 15 type type NN 10_1101-2020_03_27_012757 306 16 , , , 10_1101-2020_03_27_012757 306 17 CCN CCN NNP 10_1101-2020_03_27_012757 306 18 then then RB 10_1101-2020_03_27_012757 306 19 selected select VBD 10_1101-2020_03_27_012757 306 20 top top JJ 10_1101-2020_03_27_012757 306 21 m m NNP 10_1101-2020_03_27_012757 306 22 606 606 CD 10_1101-2020_03_27_012757 306 23 discriminative discriminative JJ 10_1101-2020_03_27_012757 306 24 gene gene NN 10_1101-2020_03_27_012757 306 25 pairs pair NNS 10_1101-2020_03_27_012757 306 26 ( ( -LRB- 10_1101-2020_03_27_012757 306 27 CCN CCN NNP 10_1101-2020_03_27_012757 306 28 training training NN 10_1101-2020_03_27_012757 306 29 parameter parameter NN 10_1101-2020_03_27_012757 306 30 nTopGenePairs nTopGenePairs NNP 10_1101-2020_03_27_012757 306 31 = = SYM 10_1101-2020_03_27_012757 306 32 m m NN 10_1101-2020_03_27_012757 306 33 ) ) -RRB- 10_1101-2020_03_27_012757 306 34 for for IN 10_1101-2020_03_27_012757 306 35 each each DT 10_1101-2020_03_27_012757 306 36 category category NN 10_1101-2020_03_27_012757 306 37 using use VBG 10_1101-2020_03_27_012757 306 38 607 607 CD 10_1101-2020_03_27_012757 306 39 template template NN 10_1101-2020_03_27_012757 306 40 matching matching NN 10_1101-2020_03_27_012757 306 41 ( ( -LRB- 10_1101-2020_03_27_012757 306 42 with with IN 10_1101-2020_03_27_012757 306 43 large large JJ 10_1101-2020_03_27_012757 306 44 absolute absolute JJ 10_1101-2020_03_27_012757 306 45 Pearson Pearson NNP 10_1101-2020_03_27_012757 306 46 correlation correlation NN 10_1101-2020_03_27_012757 306 47 coefficient coefficient NN 10_1101-2020_03_27_012757 306 48 ) ) -RRB- 10_1101-2020_03_27_012757 306 49 described describe VBN 10_1101-2020_03_27_012757 306 50 above above RB 10_1101-2020_03_27_012757 306 51 . . . 10_1101-2020_03_27_012757 307 1 To to IN 10_1101-2020_03_27_012757 307 2 608 608 CD 10_1101-2020_03_27_012757 307 3 prevent prevent VB 10_1101-2020_03_27_012757 307 4 any any DT 10_1101-2020_03_27_012757 307 5 single single JJ 10_1101-2020_03_27_012757 307 6 gene gene NN 10_1101-2020_03_27_012757 307 7 from from IN 10_1101-2020_03_27_012757 307 8 dominating dominate VBG 10_1101-2020_03_27_012757 307 9 the the DT 10_1101-2020_03_27_012757 307 10 gene gene NN 10_1101-2020_03_27_012757 307 11 pair pair NN 10_1101-2020_03_27_012757 307 12 list list NN 10_1101-2020_03_27_012757 307 13 , , , 10_1101-2020_03_27_012757 307 14 we -PRON- PRP 10_1101-2020_03_27_012757 307 15 allowed allow VBD 10_1101-2020_03_27_012757 307 16 each each DT 10_1101-2020_03_27_012757 307 17 gene gene NN 10_1101-2020_03_27_012757 307 18 to to TO 10_1101-2020_03_27_012757 307 19 appear appear VB 10_1101-2020_03_27_012757 307 20 at at IN 10_1101-2020_03_27_012757 307 21 609 609 CD 10_1101-2020_03_27_012757 307 22 maximum maximum NN 10_1101-2020_03_27_012757 307 23 of of IN 10_1101-2020_03_27_012757 307 24 three three CD 10_1101-2020_03_27_012757 307 25 times time NNS 10_1101-2020_03_27_012757 307 26 among among IN 10_1101-2020_03_27_012757 307 27 the the DT 10_1101-2020_03_27_012757 307 28 gene gene NN 10_1101-2020_03_27_012757 307 29 pairs pair NNS 10_1101-2020_03_27_012757 307 30 selected select VBN 10_1101-2020_03_27_012757 307 31 as as IN 10_1101-2020_03_27_012757 307 32 features feature NNS 10_1101-2020_03_27_012757 307 33 per per IN 10_1101-2020_03_27_012757 307 34 cancer cancer NN 10_1101-2020_03_27_012757 307 35 type type NN 10_1101-2020_03_27_012757 307 36 . . . 10_1101-2020_03_27_012757 308 1 610 610 CD 10_1101-2020_03_27_012757 308 2 After after IN 10_1101-2020_03_27_012757 308 3 the the DT 10_1101-2020_03_27_012757 308 4 top top JJ 10_1101-2020_03_27_012757 308 5 discriminative discriminative JJ 10_1101-2020_03_27_012757 308 6 gene gene NN 10_1101-2020_03_27_012757 308 7 pairs pair NNS 10_1101-2020_03_27_012757 308 8 were be VBD 10_1101-2020_03_27_012757 308 9 selected select VBN 10_1101-2020_03_27_012757 308 10 for for IN 10_1101-2020_03_27_012757 308 11 each each DT 10_1101-2020_03_27_012757 308 12 cancer cancer NN 10_1101-2020_03_27_012757 308 13 category category NN 10_1101-2020_03_27_012757 308 14 , , , 10_1101-2020_03_27_012757 308 15 CCN CCN NNP 10_1101-2020_03_27_012757 308 16 611 611 CD 10_1101-2020_03_27_012757 308 17 grouped group VBD 10_1101-2020_03_27_012757 308 18 all all PDT 10_1101-2020_03_27_012757 308 19 the the DT 10_1101-2020_03_27_012757 308 20 gene gene NN 10_1101-2020_03_27_012757 308 21 pairs pair NNS 10_1101-2020_03_27_012757 308 22 together together RB 10_1101-2020_03_27_012757 308 23 and and CC 10_1101-2020_03_27_012757 308 24 gene gene NN 10_1101-2020_03_27_012757 308 25 pair pair NN 10_1101-2020_03_27_012757 308 26 transformed transform VBD 10_1101-2020_03_27_012757 308 27 the the DT 10_1101-2020_03_27_012757 308 28 training training NN 10_1101-2020_03_27_012757 308 29 samples sample NNS 10_1101-2020_03_27_012757 308 30 into into IN 10_1101-2020_03_27_012757 308 31 a a DT 10_1101-2020_03_27_012757 308 32 binary binary JJ 10_1101-2020_03_27_012757 308 33 612 612 CD 10_1101-2020_03_27_012757 308 34 matrix matrix NN 10_1101-2020_03_27_012757 308 35 with with IN 10_1101-2020_03_27_012757 308 36 all all PDT 10_1101-2020_03_27_012757 308 37 the the DT 10_1101-2020_03_27_012757 308 38 discriminative discriminative JJ 10_1101-2020_03_27_012757 308 39 gene gene NN 10_1101-2020_03_27_012757 308 40 pairs pair NNS 10_1101-2020_03_27_012757 308 41 as as IN 10_1101-2020_03_27_012757 308 42 row row NN 10_1101-2020_03_27_012757 308 43 names name NNS 10_1101-2020_03_27_012757 308 44 and and CC 10_1101-2020_03_27_012757 308 45 all all PDT 10_1101-2020_03_27_012757 308 46 the the DT 10_1101-2020_03_27_012757 308 47 training training NN 10_1101-2020_03_27_012757 308 48 samples sample NNS 10_1101-2020_03_27_012757 308 49 as as IN 10_1101-2020_03_27_012757 308 50 613 613 CD 10_1101-2020_03_27_012757 308 51 column column NN 10_1101-2020_03_27_012757 308 52 names name NNS 10_1101-2020_03_27_012757 308 53 . . . 10_1101-2020_03_27_012757 309 1 Using use VBG 10_1101-2020_03_27_012757 309 2 the the DT 10_1101-2020_03_27_012757 309 3 binary binary JJ 10_1101-2020_03_27_012757 309 4 gene gene NN 10_1101-2020_03_27_012757 309 5 pair pair NN 10_1101-2020_03_27_012757 309 6 matrix matrix NNP 10_1101-2020_03_27_012757 309 7 , , , 10_1101-2020_03_27_012757 309 8 CCN CCN NNP 10_1101-2020_03_27_012757 309 9 randomly randomly RB 10_1101-2020_03_27_012757 309 10 shuffled shuffle VBD 10_1101-2020_03_27_012757 309 11 the the DT 10_1101-2020_03_27_012757 309 12 binary binary JJ 10_1101-2020_03_27_012757 309 13 values value NNS 10_1101-2020_03_27_012757 309 14 614 614 CD 10_1101-2020_03_27_012757 309 15 across across IN 10_1101-2020_03_27_012757 309 16 rows row NNS 10_1101-2020_03_27_012757 309 17 then then RB 10_1101-2020_03_27_012757 309 18 across across IN 10_1101-2020_03_27_012757 309 19 columns column NNS 10_1101-2020_03_27_012757 309 20 to to TO 10_1101-2020_03_27_012757 309 21 generate generate VB 10_1101-2020_03_27_012757 309 22 random random JJ 10_1101-2020_03_27_012757 309 23 profiles profile NNS 10_1101-2020_03_27_012757 309 24 that that WDT 10_1101-2020_03_27_012757 309 25 should should MD 10_1101-2020_03_27_012757 309 26 not not RB 10_1101-2020_03_27_012757 309 27 resemble resemble VB 10_1101-2020_03_27_012757 309 28 training train VBG 10_1101-2020_03_27_012757 309 29 615 615 CD 10_1101-2020_03_27_012757 309 30 data datum NNS 10_1101-2020_03_27_012757 309 31 from from IN 10_1101-2020_03_27_012757 309 32 any any DT 10_1101-2020_03_27_012757 309 33 of of IN 10_1101-2020_03_27_012757 309 34 the the DT 10_1101-2020_03_27_012757 309 35 cancer cancer NN 10_1101-2020_03_27_012757 309 36 categories category NNS 10_1101-2020_03_27_012757 309 37 . . . 10_1101-2020_03_27_012757 310 1 CCN CCN NNP 10_1101-2020_03_27_012757 310 2 then then RB 10_1101-2020_03_27_012757 310 3 sampled sample VBD 10_1101-2020_03_27_012757 310 4 70 70 CD 10_1101-2020_03_27_012757 310 5 random random JJ 10_1101-2020_03_27_012757 310 6 profiles profile NNS 10_1101-2020_03_27_012757 310 7 , , , 10_1101-2020_03_27_012757 310 8 annotated annotate VBD 10_1101-2020_03_27_012757 310 9 them -PRON- PRP 10_1101-2020_03_27_012757 310 10 616 616 CD 10_1101-2020_03_27_012757 310 11 as as IN 10_1101-2020_03_27_012757 310 12 “ " `` 10_1101-2020_03_27_012757 310 13 Unknown unknown JJ 10_1101-2020_03_27_012757 310 14 ” " '' 10_1101-2020_03_27_012757 310 15 and and CC 10_1101-2020_03_27_012757 310 16 used use VBD 10_1101-2020_03_27_012757 310 17 them -PRON- PRP 10_1101-2020_03_27_012757 310 18 as as IN 10_1101-2020_03_27_012757 310 19 training training NN 10_1101-2020_03_27_012757 310 20 data datum NNS 10_1101-2020_03_27_012757 310 21 for for IN 10_1101-2020_03_27_012757 310 22 the the DT 10_1101-2020_03_27_012757 310 23 “ " `` 10_1101-2020_03_27_012757 310 24 Unknown unknown JJ 10_1101-2020_03_27_012757 310 25 ” " '' 10_1101-2020_03_27_012757 310 26 category category NN 10_1101-2020_03_27_012757 310 27 . . . 10_1101-2020_03_27_012757 311 1 Using use VBG 10_1101-2020_03_27_012757 311 2 gene gene NN 10_1101-2020_03_27_012757 311 3 pair pair NN 10_1101-2020_03_27_012757 311 4 617 617 CD 10_1101-2020_03_27_012757 311 5 binary binary JJ 10_1101-2020_03_27_012757 311 6 training training NN 10_1101-2020_03_27_012757 311 7 matrix matrix NN 10_1101-2020_03_27_012757 311 8 , , , 10_1101-2020_03_27_012757 311 9 CCN CCN NNP 10_1101-2020_03_27_012757 311 10 constructed construct VBD 10_1101-2020_03_27_012757 311 11 a a DT 10_1101-2020_03_27_012757 311 12 multi multi JJ 10_1101-2020_03_27_012757 311 13 - - JJ 10_1101-2020_03_27_012757 311 14 class class JJ 10_1101-2020_03_27_012757 311 15 Random Random NNP 10_1101-2020_03_27_012757 311 16 Forest Forest NNP 10_1101-2020_03_27_012757 311 17 classifier classifier NN 10_1101-2020_03_27_012757 311 18 of of IN 10_1101-2020_03_27_012757 311 19 2000 2000 CD 10_1101-2020_03_27_012757 311 20 trees tree NNS 10_1101-2020_03_27_012757 311 21 618 618 CD 10_1101-2020_03_27_012757 311 22 and and CC 10_1101-2020_03_27_012757 311 23 used use VBD 10_1101-2020_03_27_012757 311 24 stratified stratify VBN 10_1101-2020_03_27_012757 311 25 sampling sampling NN 10_1101-2020_03_27_012757 311 26 of of IN 10_1101-2020_03_27_012757 311 27 60 60 CD 10_1101-2020_03_27_012757 311 28 sample sample NN 10_1101-2020_03_27_012757 311 29 size size NN 10_1101-2020_03_27_012757 311 30 to to TO 10_1101-2020_03_27_012757 311 31 ensure ensure VB 10_1101-2020_03_27_012757 311 32 balance balance NN 10_1101-2020_03_27_012757 311 33 of of IN 10_1101-2020_03_27_012757 311 34 training training NN 10_1101-2020_03_27_012757 311 35 data datum NNS 10_1101-2020_03_27_012757 311 36 in in IN 10_1101-2020_03_27_012757 311 37 constructing construct VBG 10_1101-2020_03_27_012757 311 38 619 619 CD 10_1101-2020_03_27_012757 311 39 the the DT 10_1101-2020_03_27_012757 311 40 decision decision NN 10_1101-2020_03_27_012757 311 41 trees tree NNS 10_1101-2020_03_27_012757 311 42 . . . 10_1101-2020_03_27_012757 312 1 620 620 CD 10_1101-2020_03_27_012757 312 2 To to TO 10_1101-2020_03_27_012757 312 3 identify identify VB 10_1101-2020_03_27_012757 312 4 the the DT 10_1101-2020_03_27_012757 312 5 best good JJS 10_1101-2020_03_27_012757 312 6 set set NN 10_1101-2020_03_27_012757 312 7 of of IN 10_1101-2020_03_27_012757 312 8 genes gene NNS 10_1101-2020_03_27_012757 312 9 and and CC 10_1101-2020_03_27_012757 312 10 gene gene NN 10_1101-2020_03_27_012757 312 11 - - HYPH 10_1101-2020_03_27_012757 312 12 pair pair NN 10_1101-2020_03_27_012757 312 13 parameters parameter NNS 10_1101-2020_03_27_012757 312 14 ( ( -LRB- 10_1101-2020_03_27_012757 312 15 n n NNP 10_1101-2020_03_27_012757 312 16 and and CC 10_1101-2020_03_27_012757 312 17 m m NNP 10_1101-2020_03_27_012757 312 18 ) ) -RRB- 10_1101-2020_03_27_012757 312 19 , , , 10_1101-2020_03_27_012757 312 20 we -PRON- PRP 10_1101-2020_03_27_012757 312 21 used use VBD 10_1101-2020_03_27_012757 312 22 a a DT 10_1101-2020_03_27_012757 312 23 grid-621 grid-621 JJ 10_1101-2020_03_27_012757 312 24 search search NN 10_1101-2020_03_27_012757 312 25 cross cross NN 10_1101-2020_03_27_012757 312 26 - - JJ 10_1101-2020_03_27_012757 312 27 validation89 validation89 NNP 10_1101-2020_03_27_012757 312 28 strategy strategy NN 10_1101-2020_03_27_012757 312 29 with with IN 10_1101-2020_03_27_012757 312 30 5 5 CD 10_1101-2020_03_27_012757 312 31 cross cross NN 10_1101-2020_03_27_012757 312 32 - - NNS 10_1101-2020_03_27_012757 312 33 validations validation NNS 10_1101-2020_03_27_012757 312 34 at at IN 10_1101-2020_03_27_012757 312 35 each each DT 10_1101-2020_03_27_012757 312 36 parameter parameter NN 10_1101-2020_03_27_012757 312 37 set set NN 10_1101-2020_03_27_012757 312 38 . . . 10_1101-2020_03_27_012757 313 1 The the DT 10_1101-2020_03_27_012757 313 2 specific specific JJ 10_1101-2020_03_27_012757 313 3 622 622 CD 10_1101-2020_03_27_012757 313 4 parameters parameter NNS 10_1101-2020_03_27_012757 313 5 for for IN 10_1101-2020_03_27_012757 313 6 the the DT 10_1101-2020_03_27_012757 313 7 final final JJ 10_1101-2020_03_27_012757 313 8 CCN CCN NNP 10_1101-2020_03_27_012757 313 9 classifier classifier NN 10_1101-2020_03_27_012757 313 10 using use VBG 10_1101-2020_03_27_012757 313 11 the the DT 10_1101-2020_03_27_012757 313 12 function function NN 10_1101-2020_03_27_012757 313 13 “ " `` 10_1101-2020_03_27_012757 313 14 broadClass_train broadclass_train NN 10_1101-2020_03_27_012757 313 15 ” " '' 10_1101-2020_03_27_012757 313 16 in in IN 10_1101-2020_03_27_012757 313 17 the the DT 10_1101-2020_03_27_012757 313 18 package package NN 10_1101-2020_03_27_012757 313 19 623 623 CD 10_1101-2020_03_27_012757 313 20 cancerCellNet cancerCellNet NNS 10_1101-2020_03_27_012757 313 21 are be VBP 10_1101-2020_03_27_012757 313 22 in in IN 10_1101-2020_03_27_012757 313 23 Supp Supp NNP 10_1101-2020_03_27_012757 313 24 Tab Tab NNP 10_1101-2020_03_27_012757 313 25 9 9 CD 10_1101-2020_03_27_012757 313 26 . . . 10_1101-2020_03_27_012757 314 1 The the DT 10_1101-2020_03_27_012757 314 2 gene gene NN 10_1101-2020_03_27_012757 314 3 - - HYPH 10_1101-2020_03_27_012757 314 4 pairs pair NNS 10_1101-2020_03_27_012757 314 5 are be VBP 10_1101-2020_03_27_012757 314 6 in in IN 10_1101-2020_03_27_012757 314 7 Supp Supp NNP 10_1101-2020_03_27_012757 314 8 Tab Tab NNP 10_1101-2020_03_27_012757 314 9 10 10 CD 10_1101-2020_03_27_012757 314 10 . . . 10_1101-2020_03_27_012757 315 1 624 624 CD 10_1101-2020_03_27_012757 315 2 625 625 CD 10_1101-2020_03_27_012757 315 3 Validating Validating NNP 10_1101-2020_03_27_012757 315 4 General general JJ 10_1101-2020_03_27_012757 315 5 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 315 6 Classifier Classifier NNP 10_1101-2020_03_27_012757 315 7 626 626 CD 10_1101-2020_03_27_012757 315 8 Two two CD 10_1101-2020_03_27_012757 315 9 thirds third NNS 10_1101-2020_03_27_012757 315 10 of of IN 10_1101-2020_03_27_012757 315 11 patient patient JJ 10_1101-2020_03_27_012757 315 12 tumor tumor NN 10_1101-2020_03_27_012757 315 13 data datum NNS 10_1101-2020_03_27_012757 315 14 from from IN 10_1101-2020_03_27_012757 315 15 each each DT 10_1101-2020_03_27_012757 315 16 cancer cancer NN 10_1101-2020_03_27_012757 315 17 type type NN 10_1101-2020_03_27_012757 315 18 were be VBD 10_1101-2020_03_27_012757 315 19 randomly randomly RB 10_1101-2020_03_27_012757 315 20 sampled sample VBN 10_1101-2020_03_27_012757 315 21 as as IN 10_1101-2020_03_27_012757 315 22 627 627 CD 10_1101-2020_03_27_012757 315 23 training training NN 10_1101-2020_03_27_012757 315 24 data datum NNS 10_1101-2020_03_27_012757 315 25 to to TO 10_1101-2020_03_27_012757 315 26 construct construct VB 10_1101-2020_03_27_012757 315 27 a a DT 10_1101-2020_03_27_012757 315 28 CCN ccn NN 10_1101-2020_03_27_012757 315 29 classifier classifier NN 10_1101-2020_03_27_012757 315 30 . . . 10_1101-2020_03_27_012757 316 1 Based base VBN 10_1101-2020_03_27_012757 316 2 on on IN 10_1101-2020_03_27_012757 316 3 the the DT 10_1101-2020_03_27_012757 316 4 training training NN 10_1101-2020_03_27_012757 316 5 data datum NNS 10_1101-2020_03_27_012757 316 6 , , , 10_1101-2020_03_27_012757 316 7 CCN CCN NNP 10_1101-2020_03_27_012757 316 8 selected select VBD 10_1101-2020_03_27_012757 316 9 the the DT 10_1101-2020_03_27_012757 316 10 628 628 CD 10_1101-2020_03_27_012757 316 11 classification classification NN 10_1101-2020_03_27_012757 316 12 genes gene NNS 10_1101-2020_03_27_012757 316 13 and and CC 10_1101-2020_03_27_012757 316 14 gene gene NN 10_1101-2020_03_27_012757 316 15 - - HYPH 10_1101-2020_03_27_012757 316 16 pairs pair NNS 10_1101-2020_03_27_012757 316 17 and and CC 10_1101-2020_03_27_012757 316 18 trained train VBD 10_1101-2020_03_27_012757 316 19 a a DT 10_1101-2020_03_27_012757 316 20 classifier classifier NN 10_1101-2020_03_27_012757 316 21 . . . 10_1101-2020_03_27_012757 317 1 After after IN 10_1101-2020_03_27_012757 317 2 the the DT 10_1101-2020_03_27_012757 317 3 classifier classifier NN 10_1101-2020_03_27_012757 317 4 was be VBD 10_1101-2020_03_27_012757 317 5 built build VBN 10_1101-2020_03_27_012757 317 6 , , , 10_1101-2020_03_27_012757 317 7 35 35 CD 10_1101-2020_03_27_012757 317 8 629 629 CD 10_1101-2020_03_27_012757 317 9 .CC .CC : 10_1101-2020_03_27_012757 317 10 - - HYPH 10_1101-2020_03_27_012757 317 11 BY by IN 10_1101-2020_03_27_012757 317 12 - - HYPH 10_1101-2020_03_27_012757 317 13 NC NC NNP 10_1101-2020_03_27_012757 317 14 - - HYPH 10_1101-2020_03_27_012757 317 15 ND ND NNP 10_1101-2020_03_27_012757 317 16 4.0 4.0 CD 10_1101-2020_03_27_012757 317 17 International International NNP 10_1101-2020_03_27_012757 317 18 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 317 19 under under IN 10_1101-2020_03_27_012757 317 20 a a DT 10_1101-2020_03_27_012757 317 21 ( ( -LRB- 10_1101-2020_03_27_012757 317 22 which which WDT 10_1101-2020_03_27_012757 317 23 was be VBD 10_1101-2020_03_27_012757 317 24 not not RB 10_1101-2020_03_27_012757 317 25 certified certify VBN 10_1101-2020_03_27_012757 317 26 by by IN 10_1101-2020_03_27_012757 317 27 peer peer NN 10_1101-2020_03_27_012757 317 28 review review NN 10_1101-2020_03_27_012757 317 29 ) ) -RRB- 10_1101-2020_03_27_012757 317 30 is be VBZ 10_1101-2020_03_27_012757 317 31 the the DT 10_1101-2020_03_27_012757 317 32 author author NN 10_1101-2020_03_27_012757 317 33 / / SYM 10_1101-2020_03_27_012757 317 34 funder funder NN 10_1101-2020_03_27_012757 317 35 , , , 10_1101-2020_03_27_012757 317 36 who who WP 10_1101-2020_03_27_012757 317 37 has have VBZ 10_1101-2020_03_27_012757 317 38 granted grant VBN 10_1101-2020_03_27_012757 317 39 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 317 40 a a DT 10_1101-2020_03_27_012757 317 41 license license NN 10_1101-2020_03_27_012757 317 42 to to TO 10_1101-2020_03_27_012757 317 43 display display VB 10_1101-2020_03_27_012757 317 44 the the DT 10_1101-2020_03_27_012757 317 45 preprint preprint NN 10_1101-2020_03_27_012757 317 46 in in IN 10_1101-2020_03_27_012757 317 47 perpetuity perpetuity NN 10_1101-2020_03_27_012757 317 48 . . . 10_1101-2020_03_27_012757 318 1 It -PRON- PRP 10_1101-2020_03_27_012757 318 2 is be VBZ 10_1101-2020_03_27_012757 318 3 made make VBN 10_1101-2020_03_27_012757 318 4 The the DT 10_1101-2020_03_27_012757 318 5 copyright copyright NN 10_1101-2020_03_27_012757 318 6 holder holder NN 10_1101-2020_03_27_012757 318 7 for for IN 10_1101-2020_03_27_012757 318 8 this this DT 10_1101-2020_03_27_012757 318 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 318 10 version version NN 10_1101-2020_03_27_012757 318 11 posted post VBD 10_1101-2020_03_27_012757 318 12 January January NNP 10_1101-2020_03_27_012757 318 13 9 9 CD 10_1101-2020_03_27_012757 318 14 , , , 10_1101-2020_03_27_012757 318 15 2021 2021 CD 10_1101-2020_03_27_012757 318 16 . . . 10_1101-2020_03_27_012757 318 17 ; ; : 10_1101-2020_03_27_012757 318 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 318 19 : : : 10_1101-2020_03_27_012757 318 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 318 21 preprint preprint NN 10_1101-2020_03_27_012757 318 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 318 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ RB 10_1101-2020_03_27_012757 318 24 24 24 CD 10_1101-2020_03_27_012757 318 25 held hold VBN 10_1101-2020_03_27_012757 318 26 - - HYPH 10_1101-2020_03_27_012757 318 27 out out RP 10_1101-2020_03_27_012757 318 28 samples sample NNS 10_1101-2020_03_27_012757 318 29 from from IN 10_1101-2020_03_27_012757 318 30 each each DT 10_1101-2020_03_27_012757 318 31 cancer cancer NN 10_1101-2020_03_27_012757 318 32 category category NN 10_1101-2020_03_27_012757 318 33 were be VBD 10_1101-2020_03_27_012757 318 34 sampled sample VBN 10_1101-2020_03_27_012757 318 35 and and CC 10_1101-2020_03_27_012757 318 36 40 40 CD 10_1101-2020_03_27_012757 318 37 “ " `` 10_1101-2020_03_27_012757 318 38 Unknown unknown JJ 10_1101-2020_03_27_012757 318 39 ” " '' 10_1101-2020_03_27_012757 318 40 profiles profile NNS 10_1101-2020_03_27_012757 318 41 were be VBD 10_1101-2020_03_27_012757 318 42 630 630 CD 10_1101-2020_03_27_012757 318 43 generated generate VBN 10_1101-2020_03_27_012757 318 44 for for IN 10_1101-2020_03_27_012757 318 45 validation validation NN 10_1101-2020_03_27_012757 318 46 . . . 10_1101-2020_03_27_012757 319 1 The the DT 10_1101-2020_03_27_012757 319 2 process process NN 10_1101-2020_03_27_012757 319 3 of of IN 10_1101-2020_03_27_012757 319 4 randomly randomly RB 10_1101-2020_03_27_012757 319 5 sampling sample VBG 10_1101-2020_03_27_012757 319 6 training training NN 10_1101-2020_03_27_012757 319 7 set set VBN 10_1101-2020_03_27_012757 319 8 from from IN 10_1101-2020_03_27_012757 319 9 2/3 2/3 CD 10_1101-2020_03_27_012757 319 10 of of IN 10_1101-2020_03_27_012757 319 11 all all DT 10_1101-2020_03_27_012757 319 12 patient patient JJ 10_1101-2020_03_27_012757 319 13 631 631 CD 10_1101-2020_03_27_012757 319 14 tumor tumor NN 10_1101-2020_03_27_012757 319 15 data datum NNS 10_1101-2020_03_27_012757 319 16 , , , 10_1101-2020_03_27_012757 319 17 selecting select VBG 10_1101-2020_03_27_012757 319 18 features feature NNS 10_1101-2020_03_27_012757 319 19 based base VBN 10_1101-2020_03_27_012757 319 20 on on IN 10_1101-2020_03_27_012757 319 21 the the DT 10_1101-2020_03_27_012757 319 22 training training NN 10_1101-2020_03_27_012757 319 23 set set NN 10_1101-2020_03_27_012757 319 24 , , , 10_1101-2020_03_27_012757 319 25 training train VBG 10_1101-2020_03_27_012757 319 26 classifier classifier NN 10_1101-2020_03_27_012757 319 27 and and CC 10_1101-2020_03_27_012757 319 28 validating validating NN 10_1101-2020_03_27_012757 319 29 was be VBD 10_1101-2020_03_27_012757 319 30 632 632 CD 10_1101-2020_03_27_012757 319 31 repeated repeat VBN 10_1101-2020_03_27_012757 319 32 50 50 CD 10_1101-2020_03_27_012757 319 33 times time NNS 10_1101-2020_03_27_012757 319 34 to to TO 10_1101-2020_03_27_012757 319 35 have have VB 10_1101-2020_03_27_012757 319 36 a a DT 10_1101-2020_03_27_012757 319 37 more more RBR 10_1101-2020_03_27_012757 319 38 comprehensive comprehensive JJ 10_1101-2020_03_27_012757 319 39 assessment assessment NN 10_1101-2020_03_27_012757 319 40 of of IN 10_1101-2020_03_27_012757 319 41 the the DT 10_1101-2020_03_27_012757 319 42 classifier classifier NN 10_1101-2020_03_27_012757 319 43 trained train VBN 10_1101-2020_03_27_012757 319 44 with with IN 10_1101-2020_03_27_012757 319 45 the the DT 10_1101-2020_03_27_012757 319 46 633 633 CD 10_1101-2020_03_27_012757 319 47 optimal optimal JJ 10_1101-2020_03_27_012757 319 48 parameter parameter NN 10_1101-2020_03_27_012757 319 49 set set NN 10_1101-2020_03_27_012757 319 50 . . . 10_1101-2020_03_27_012757 320 1 To to TO 10_1101-2020_03_27_012757 320 2 test test VB 10_1101-2020_03_27_012757 320 3 the the DT 10_1101-2020_03_27_012757 320 4 performance performance NN 10_1101-2020_03_27_012757 320 5 of of IN 10_1101-2020_03_27_012757 320 6 final final JJ 10_1101-2020_03_27_012757 320 7 CCN CCN NNP 10_1101-2020_03_27_012757 320 8 on on IN 10_1101-2020_03_27_012757 320 9 independent independent JJ 10_1101-2020_03_27_012757 320 10 testing testing NN 10_1101-2020_03_27_012757 320 11 data datum NNS 10_1101-2020_03_27_012757 320 12 , , , 10_1101-2020_03_27_012757 320 13 we -PRON- PRP 10_1101-2020_03_27_012757 320 14 634 634 CD 10_1101-2020_03_27_012757 320 15 applied apply VBD 10_1101-2020_03_27_012757 320 16 it -PRON- PRP 10_1101-2020_03_27_012757 320 17 to to IN 10_1101-2020_03_27_012757 320 18 725 725 CD 10_1101-2020_03_27_012757 320 19 profiles profile NNS 10_1101-2020_03_27_012757 320 20 from from IN 10_1101-2020_03_27_012757 320 21 ICGC ICGC NNP 10_1101-2020_03_27_012757 320 22 spanning span VBG 10_1101-2020_03_27_012757 320 23 6 6 CD 10_1101-2020_03_27_012757 320 24 projects project NNS 10_1101-2020_03_27_012757 320 25 that that WDT 10_1101-2020_03_27_012757 320 26 do do VBP 10_1101-2020_03_27_012757 320 27 not not RB 10_1101-2020_03_27_012757 320 28 overlap overlap VB 10_1101-2020_03_27_012757 320 29 with with IN 10_1101-2020_03_27_012757 320 30 TCGA TCGA NNP 10_1101-2020_03_27_012757 320 31 ( ( -LRB- 10_1101-2020_03_27_012757 320 32 BRCA-635 BRCA-635 NNP 10_1101-2020_03_27_012757 320 33 KR KR NNP 10_1101-2020_03_27_012757 320 34 , , , 10_1101-2020_03_27_012757 320 35 LIRI LIRI NNP 10_1101-2020_03_27_012757 320 36 - - HYPH 10_1101-2020_03_27_012757 320 37 JP JP NNP 10_1101-2020_03_27_012757 320 38 , , , 10_1101-2020_03_27_012757 320 39 OV OV NNP 10_1101-2020_03_27_012757 320 40 - - HYPH 10_1101-2020_03_27_012757 320 41 AU AU NNP 10_1101-2020_03_27_012757 320 42 , , , 10_1101-2020_03_27_012757 320 43 PACA PACA NNP 10_1101-2020_03_27_012757 320 44 - - HYPH 10_1101-2020_03_27_012757 320 45 AU AU NNP 10_1101-2020_03_27_012757 320 46 , , , 10_1101-2020_03_27_012757 320 47 PACA PACA NNP 10_1101-2020_03_27_012757 320 48 - - HYPH 10_1101-2020_03_27_012757 320 49 CA CA NNP 10_1101-2020_03_27_012757 320 50 , , , 10_1101-2020_03_27_012757 320 51 PRAD PRAD NNP 10_1101-2020_03_27_012757 320 52 - - HYPH 10_1101-2020_03_27_012757 320 53 FR FR NNP 10_1101-2020_03_27_012757 320 54 ) ) -RRB- 10_1101-2020_03_27_012757 320 55 . . . 10_1101-2020_03_27_012757 321 1 636 636 CD 10_1101-2020_03_27_012757 321 2 637 637 CD 10_1101-2020_03_27_012757 321 3 Selecting Selecting NNP 10_1101-2020_03_27_012757 321 4 Decision decision NN 10_1101-2020_03_27_012757 321 5 Thresholds Thresholds NNP 10_1101-2020_03_27_012757 321 6 638 638 CD 10_1101-2020_03_27_012757 321 7 Our -PRON- PRP$ 10_1101-2020_03_27_012757 321 8 strategy strategy NN 10_1101-2020_03_27_012757 321 9 for for IN 10_1101-2020_03_27_012757 321 10 selecting select VBG 10_1101-2020_03_27_012757 321 11 a a DT 10_1101-2020_03_27_012757 321 12 decision decision NN 10_1101-2020_03_27_012757 321 13 threshold threshold NN 10_1101-2020_03_27_012757 321 14 was be VBD 10_1101-2020_03_27_012757 321 15 to to TO 10_1101-2020_03_27_012757 321 16 find find VB 10_1101-2020_03_27_012757 321 17 the the DT 10_1101-2020_03_27_012757 321 18 value value NN 10_1101-2020_03_27_012757 321 19 that that WDT 10_1101-2020_03_27_012757 321 20 maximizes maximize VBZ 10_1101-2020_03_27_012757 321 21 the the DT 10_1101-2020_03_27_012757 321 22 639 639 CD 10_1101-2020_03_27_012757 321 23 average average JJ 10_1101-2020_03_27_012757 321 24 Macro Macro NNP 10_1101-2020_03_27_012757 321 25 F1 F1 NNP 10_1101-2020_03_27_012757 321 26 measure90 measure90 NNS 10_1101-2020_03_27_012757 321 27 for for IN 10_1101-2020_03_27_012757 321 28 each each DT 10_1101-2020_03_27_012757 321 29 of of IN 10_1101-2020_03_27_012757 321 30 the the DT 10_1101-2020_03_27_012757 321 31 50 50 CD 10_1101-2020_03_27_012757 321 32 cross cros NNS 10_1101-2020_03_27_012757 321 33 - - NNS 10_1101-2020_03_27_012757 321 34 validations validation NNS 10_1101-2020_03_27_012757 321 35 that that WDT 10_1101-2020_03_27_012757 321 36 were be VBD 10_1101-2020_03_27_012757 321 37 performed perform VBN 10_1101-2020_03_27_012757 321 38 with with IN 10_1101-2020_03_27_012757 321 39 the the DT 10_1101-2020_03_27_012757 321 40 640 640 CD 10_1101-2020_03_27_012757 321 41 optimal optimal JJ 10_1101-2020_03_27_012757 321 42 parameter parameter NN 10_1101-2020_03_27_012757 321 43 set set NN 10_1101-2020_03_27_012757 321 44 , , , 10_1101-2020_03_27_012757 321 45 testing test VBG 10_1101-2020_03_27_012757 321 46 thresholds threshold NNS 10_1101-2020_03_27_012757 321 47 between between IN 10_1101-2020_03_27_012757 321 48 0 0 CD 10_1101-2020_03_27_012757 321 49 and and CC 10_1101-2020_03_27_012757 321 50 1 1 CD 10_1101-2020_03_27_012757 321 51 with with IN 10_1101-2020_03_27_012757 321 52 a a DT 10_1101-2020_03_27_012757 321 53 0.01 0.01 CD 10_1101-2020_03_27_012757 321 54 increment increment NN 10_1101-2020_03_27_012757 321 55 . . . 10_1101-2020_03_27_012757 322 1 The the DT 10_1101-2020_03_27_012757 322 2 F1 f1 NN 10_1101-2020_03_27_012757 322 3 641 641 CD 10_1101-2020_03_27_012757 322 4 measure measure NN 10_1101-2020_03_27_012757 322 5 is be VBZ 10_1101-2020_03_27_012757 322 6 defined define VBN 10_1101-2020_03_27_012757 322 7 as as IN 10_1101-2020_03_27_012757 322 8 : : : 10_1101-2020_03_27_012757 322 9 642 642 CD 10_1101-2020_03_27_012757 322 10 𝑀𝑎𝑐𝑟𝑜 𝑀𝑎𝑐𝑟𝑜 NNP 10_1101-2020_03_27_012757 322 11 𝐹1 𝐹1 NNP 10_1101-2020_03_27_012757 322 12 = = NNS 10_1101-2020_03_27_012757 322 13 2 2 CD 10_1101-2020_03_27_012757 322 14 × × NN 10_1101-2020_03_27_012757 322 15 𝑝𝑟𝑒𝑐𝑖𝑠𝑖𝑜𝑛 𝑝𝑟𝑒𝑐𝑖𝑠𝑖𝑜𝑛 NN 10_1101-2020_03_27_012757 322 16 × × NNP 10_1101-2020_03_27_012757 322 17 𝑟𝑒𝑐𝑎𝑙𝑙 𝑟𝑒𝑐𝑎𝑙𝑙 NNP 10_1101-2020_03_27_012757 322 18 𝑝𝑟𝑒𝑐𝑖𝑠𝑖𝑜𝑛 𝑝𝑟𝑒𝑐𝑖𝑠𝑖𝑜𝑛 NNP 10_1101-2020_03_27_012757 322 19 + + CC 10_1101-2020_03_27_012757 322 20 𝑟𝑒𝑐𝑎𝑙𝑙 𝑟𝑒𝑐𝑎𝑙𝑙 NNP 10_1101-2020_03_27_012757 322 21 643 643 CD 10_1101-2020_03_27_012757 322 22 We -PRON- PRP 10_1101-2020_03_27_012757 322 23 selected select VBD 10_1101-2020_03_27_012757 322 24 the the DT 10_1101-2020_03_27_012757 322 25 most most RBS 10_1101-2020_03_27_012757 322 26 commonly commonly RB 10_1101-2020_03_27_012757 322 27 occurring occur VBG 10_1101-2020_03_27_012757 322 28 threshold threshold NN 10_1101-2020_03_27_012757 322 29 above above IN 10_1101-2020_03_27_012757 322 30 0.2 0.2 CD 10_1101-2020_03_27_012757 322 31 that that WDT 10_1101-2020_03_27_012757 322 32 maximized maximize VBD 10_1101-2020_03_27_012757 322 33 the the DT 10_1101-2020_03_27_012757 322 34 average average JJ 10_1101-2020_03_27_012757 322 35 644 644 CD 10_1101-2020_03_27_012757 322 36 Macro Macro NNP 10_1101-2020_03_27_012757 322 37 F1 F1 NNP 10_1101-2020_03_27_012757 322 38 measure measure NN 10_1101-2020_03_27_012757 322 39 across across IN 10_1101-2020_03_27_012757 322 40 the the DT 10_1101-2020_03_27_012757 322 41 50 50 CD 10_1101-2020_03_27_012757 322 42 cross cros NNS 10_1101-2020_03_27_012757 322 43 - - NNS 10_1101-2020_03_27_012757 322 44 validations validation NNS 10_1101-2020_03_27_012757 322 45 as as IN 10_1101-2020_03_27_012757 322 46 the the DT 10_1101-2020_03_27_012757 322 47 decision decision NN 10_1101-2020_03_27_012757 322 48 threshold threshold NN 10_1101-2020_03_27_012757 322 49 for for IN 10_1101-2020_03_27_012757 322 50 the the DT 10_1101-2020_03_27_012757 322 51 final final JJ 10_1101-2020_03_27_012757 322 52 645 645 CD 10_1101-2020_03_27_012757 322 53 classifier classifier NN 10_1101-2020_03_27_012757 322 54 ( ( -LRB- 10_1101-2020_03_27_012757 322 55 threshold threshold NN 10_1101-2020_03_27_012757 322 56 = = SYM 10_1101-2020_03_27_012757 322 57 0.25 0.25 CD 10_1101-2020_03_27_012757 322 58 ) ) -RRB- 10_1101-2020_03_27_012757 322 59 . . . 10_1101-2020_03_27_012757 323 1 The the DT 10_1101-2020_03_27_012757 323 2 same same JJ 10_1101-2020_03_27_012757 323 3 approach approach NN 10_1101-2020_03_27_012757 323 4 was be VBD 10_1101-2020_03_27_012757 323 5 applied apply VBN 10_1101-2020_03_27_012757 323 6 for for IN 10_1101-2020_03_27_012757 323 7 the the DT 10_1101-2020_03_27_012757 323 8 subtype subtype NN 10_1101-2020_03_27_012757 323 9 classifiers classifier NNS 10_1101-2020_03_27_012757 323 10 . . . 10_1101-2020_03_27_012757 324 1 The the DT 10_1101-2020_03_27_012757 324 2 646 646 CD 10_1101-2020_03_27_012757 324 3 thresholds threshold NNS 10_1101-2020_03_27_012757 324 4 and and CC 10_1101-2020_03_27_012757 324 5 the the DT 10_1101-2020_03_27_012757 324 6 corresponding corresponding JJ 10_1101-2020_03_27_012757 324 7 average average JJ 10_1101-2020_03_27_012757 324 8 precision precision NN 10_1101-2020_03_27_012757 324 9 , , , 10_1101-2020_03_27_012757 324 10 recall recall NN 10_1101-2020_03_27_012757 324 11 and and CC 10_1101-2020_03_27_012757 324 12 F1 f1 NN 10_1101-2020_03_27_012757 324 13 measures measure NNS 10_1101-2020_03_27_012757 324 14 are be VBP 10_1101-2020_03_27_012757 324 15 recorded record VBN 10_1101-2020_03_27_012757 324 16 in in IN 10_1101-2020_03_27_012757 324 17 647 647 CD 10_1101-2020_03_27_012757 324 18 ( ( -LRB- 10_1101-2020_03_27_012757 324 19 Supp Supp NNP 10_1101-2020_03_27_012757 324 20 Tab Tab NNP 10_1101-2020_03_27_012757 324 21 11 11 CD 10_1101-2020_03_27_012757 324 22 ) ) -RRB- 10_1101-2020_03_27_012757 324 23 . . . 10_1101-2020_03_27_012757 325 1 648 648 CD 10_1101-2020_03_27_012757 325 2 649 649 CD 10_1101-2020_03_27_012757 325 3 Classifying Classifying NNP 10_1101-2020_03_27_012757 325 4 Query Query NNP 10_1101-2020_03_27_012757 325 5 Data Data NNP 10_1101-2020_03_27_012757 325 6 into into IN 10_1101-2020_03_27_012757 325 7 General General NNP 10_1101-2020_03_27_012757 325 8 Cancer Cancer NNP 10_1101-2020_03_27_012757 325 9 Categories Categories NNPS 10_1101-2020_03_27_012757 325 10 650 650 CD 10_1101-2020_03_27_012757 325 11 We -PRON- PRP 10_1101-2020_03_27_012757 325 12 downloaded download VBD 10_1101-2020_03_27_012757 325 13 the the DT 10_1101-2020_03_27_012757 325 14 RNA RNA NNP 10_1101-2020_03_27_012757 325 15 - - HYPH 10_1101-2020_03_27_012757 325 16 seq seq NN 10_1101-2020_03_27_012757 325 17 cancer cancer NN 10_1101-2020_03_27_012757 325 18 cell cell NN 10_1101-2020_03_27_012757 325 19 lines line NNS 10_1101-2020_03_27_012757 325 20 expression expression NN 10_1101-2020_03_27_012757 325 21 profiles profile NNS 10_1101-2020_03_27_012757 325 22 and and CC 10_1101-2020_03_27_012757 325 23 sample sample NN 10_1101-2020_03_27_012757 325 24 table table NN 10_1101-2020_03_27_012757 325 25 651 651 CD 10_1101-2020_03_27_012757 325 26 from from IN 10_1101-2020_03_27_012757 325 27 ( ( -LRB- 10_1101-2020_03_27_012757 325 28 https://portals.broadinstitute.org/ccle/data https://portals.broadinstitute.org/ccle/data NNP 10_1101-2020_03_27_012757 325 29 ) ) -RRB- 10_1101-2020_03_27_012757 325 30 , , , 10_1101-2020_03_27_012757 325 31 and and CC 10_1101-2020_03_27_012757 325 32 microarray microarray JJ 10_1101-2020_03_27_012757 325 33 cancer cancer NN 10_1101-2020_03_27_012757 325 34 cell cell NN 10_1101-2020_03_27_012757 325 35 lines line NNS 10_1101-2020_03_27_012757 325 36 expression expression VBP 10_1101-2020_03_27_012757 325 37 652 652 CD 10_1101-2020_03_27_012757 325 38 profiles profile NNS 10_1101-2020_03_27_012757 325 39 and and CC 10_1101-2020_03_27_012757 325 40 sample sample NN 10_1101-2020_03_27_012757 325 41 table table NN 10_1101-2020_03_27_012757 325 42 from from IN 10_1101-2020_03_27_012757 325 43 Barretina Barretina NNP 10_1101-2020_03_27_012757 325 44 et et NNP 10_1101-2020_03_27_012757 325 45 al al NNP 10_1101-2020_03_27_012757 325 46 37 37 CD 10_1101-2020_03_27_012757 325 47 . . . 10_1101-2020_03_27_012757 326 1 We -PRON- PRP 10_1101-2020_03_27_012757 326 2 extracted extract VBD 10_1101-2020_03_27_012757 326 3 two two CD 10_1101-2020_03_27_012757 326 4 WT WT NNP 10_1101-2020_03_27_012757 326 5 control control NN 10_1101-2020_03_27_012757 326 6 NCCIT NCCIT NNP 10_1101-2020_03_27_012757 326 7 RNA RNA NNP 10_1101-2020_03_27_012757 326 8 - - HYPH 10_1101-2020_03_27_012757 326 9 seq seq NN 10_1101-2020_03_27_012757 326 10 653 653 CD 10_1101-2020_03_27_012757 326 11 expression expression NN 10_1101-2020_03_27_012757 326 12 profiles profile NNS 10_1101-2020_03_27_012757 326 13 from from IN 10_1101-2020_03_27_012757 326 14 Grow Grow NNP 10_1101-2020_03_27_012757 326 15 et et FW 10_1101-2020_03_27_012757 326 16 al91 al91 NNP 10_1101-2020_03_27_012757 326 17 . . . 10_1101-2020_03_27_012757 327 1 We -PRON- PRP 10_1101-2020_03_27_012757 327 2 received receive VBD 10_1101-2020_03_27_012757 327 3 PDX pdx NN 10_1101-2020_03_27_012757 327 4 expression expression NN 10_1101-2020_03_27_012757 327 5 estimates estimate VBZ 10_1101-2020_03_27_012757 327 6 and and CC 10_1101-2020_03_27_012757 327 7 sample sample VBP 10_1101-2020_03_27_012757 327 8 654 654 CD 10_1101-2020_03_27_012757 327 9 .CC .CC , 10_1101-2020_03_27_012757 327 10 - - HYPH 10_1101-2020_03_27_012757 327 11 BY by IN 10_1101-2020_03_27_012757 327 12 - - HYPH 10_1101-2020_03_27_012757 327 13 NC NC NNP 10_1101-2020_03_27_012757 327 14 - - HYPH 10_1101-2020_03_27_012757 327 15 ND ND NNP 10_1101-2020_03_27_012757 327 16 4.0 4.0 CD 10_1101-2020_03_27_012757 327 17 International International NNP 10_1101-2020_03_27_012757 327 18 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 327 19 under under IN 10_1101-2020_03_27_012757 327 20 a a DT 10_1101-2020_03_27_012757 327 21 ( ( -LRB- 10_1101-2020_03_27_012757 327 22 which which WDT 10_1101-2020_03_27_012757 327 23 was be VBD 10_1101-2020_03_27_012757 327 24 not not RB 10_1101-2020_03_27_012757 327 25 certified certify VBN 10_1101-2020_03_27_012757 327 26 by by IN 10_1101-2020_03_27_012757 327 27 peer peer NN 10_1101-2020_03_27_012757 327 28 review review NN 10_1101-2020_03_27_012757 327 29 ) ) -RRB- 10_1101-2020_03_27_012757 327 30 is be VBZ 10_1101-2020_03_27_012757 327 31 the the DT 10_1101-2020_03_27_012757 327 32 author author NN 10_1101-2020_03_27_012757 327 33 / / SYM 10_1101-2020_03_27_012757 327 34 funder funder NN 10_1101-2020_03_27_012757 327 35 , , , 10_1101-2020_03_27_012757 327 36 who who WP 10_1101-2020_03_27_012757 327 37 has have VBZ 10_1101-2020_03_27_012757 327 38 granted grant VBN 10_1101-2020_03_27_012757 327 39 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 327 40 a a DT 10_1101-2020_03_27_012757 327 41 license license NN 10_1101-2020_03_27_012757 327 42 to to TO 10_1101-2020_03_27_012757 327 43 display display VB 10_1101-2020_03_27_012757 327 44 the the DT 10_1101-2020_03_27_012757 327 45 preprint preprint NN 10_1101-2020_03_27_012757 327 46 in in IN 10_1101-2020_03_27_012757 327 47 perpetuity perpetuity NN 10_1101-2020_03_27_012757 327 48 . . . 10_1101-2020_03_27_012757 328 1 It -PRON- PRP 10_1101-2020_03_27_012757 328 2 is be VBZ 10_1101-2020_03_27_012757 328 3 made make VBN 10_1101-2020_03_27_012757 328 4 The the DT 10_1101-2020_03_27_012757 328 5 copyright copyright NN 10_1101-2020_03_27_012757 328 6 holder holder NN 10_1101-2020_03_27_012757 328 7 for for IN 10_1101-2020_03_27_012757 328 8 this this DT 10_1101-2020_03_27_012757 328 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 328 10 version version NN 10_1101-2020_03_27_012757 328 11 posted post VBD 10_1101-2020_03_27_012757 328 12 January January NNP 10_1101-2020_03_27_012757 328 13 9 9 CD 10_1101-2020_03_27_012757 328 14 , , , 10_1101-2020_03_27_012757 328 15 2021 2021 CD 10_1101-2020_03_27_012757 328 16 . . . 10_1101-2020_03_27_012757 328 17 ; ; : 10_1101-2020_03_27_012757 328 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 328 19 : : : 10_1101-2020_03_27_012757 328 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 328 21 preprint preprint NN 10_1101-2020_03_27_012757 328 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 328 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 328 24 25 25 CD 10_1101-2020_03_27_012757 328 25 annotations annotation NNS 10_1101-2020_03_27_012757 328 26 from from IN 10_1101-2020_03_27_012757 328 27 the the DT 10_1101-2020_03_27_012757 328 28 authors author NNS 10_1101-2020_03_27_012757 328 29 of of IN 10_1101-2020_03_27_012757 328 30 Gao Gao NNP 10_1101-2020_03_27_012757 328 31 et et NNP 10_1101-2020_03_27_012757 328 32 al al NNP 10_1101-2020_03_27_012757 328 33 20 20 CD 10_1101-2020_03_27_012757 328 34 . . . 10_1101-2020_03_27_012757 329 1 We -PRON- PRP 10_1101-2020_03_27_012757 329 2 gathered gather VBD 10_1101-2020_03_27_012757 329 3 GEMM GEMM NNP 10_1101-2020_03_27_012757 329 4 expression expression NN 10_1101-2020_03_27_012757 329 5 profiles profile NNS 10_1101-2020_03_27_012757 329 6 from from IN 10_1101-2020_03_27_012757 329 7 nine nine CD 10_1101-2020_03_27_012757 329 8 655 655 CD 10_1101-2020_03_27_012757 329 9 different different JJ 10_1101-2020_03_27_012757 329 10 studies59–67 studies59–67 NN 10_1101-2020_03_27_012757 329 11 . . . 10_1101-2020_03_27_012757 330 1 We -PRON- PRP 10_1101-2020_03_27_012757 330 2 downloaded download VBD 10_1101-2020_03_27_012757 330 3 tumoroid tumoroid NN 10_1101-2020_03_27_012757 330 4 expression expression NN 10_1101-2020_03_27_012757 330 5 profiles profile NNS 10_1101-2020_03_27_012757 330 6 from from IN 10_1101-2020_03_27_012757 330 7 The the DT 10_1101-2020_03_27_012757 330 8 NCI NCI NNP 10_1101-2020_03_27_012757 330 9 Patient-656 Patient-656 NNP 10_1101-2020_03_27_012757 330 10 Derived Derived NNP 10_1101-2020_03_27_012757 330 11 Models Models NNP 10_1101-2020_03_27_012757 330 12 Repository Repository NNP 10_1101-2020_03_27_012757 330 13 ( ( -LRB- 10_1101-2020_03_27_012757 330 14 PDMR)69 PDMR)69 NNP 10_1101-2020_03_27_012757 330 15 and and CC 10_1101-2020_03_27_012757 330 16 from from IN 10_1101-2020_03_27_012757 330 17 three three CD 10_1101-2020_03_27_012757 330 18 individual individual JJ 10_1101-2020_03_27_012757 330 19 studies70–72 studies70–72 NNS 10_1101-2020_03_27_012757 330 20 . . . 10_1101-2020_03_27_012757 331 1 To to TO 10_1101-2020_03_27_012757 331 2 use use VB 10_1101-2020_03_27_012757 331 3 CCN CCN NNP 10_1101-2020_03_27_012757 331 4 657 657 CD 10_1101-2020_03_27_012757 331 5 classifier classifier NN 10_1101-2020_03_27_012757 331 6 on on IN 10_1101-2020_03_27_012757 331 7 GEMM GEMM NNP 10_1101-2020_03_27_012757 331 8 data datum NNS 10_1101-2020_03_27_012757 331 9 , , , 10_1101-2020_03_27_012757 331 10 the the DT 10_1101-2020_03_27_012757 331 11 mouse mouse NN 10_1101-2020_03_27_012757 331 12 genes gene NNS 10_1101-2020_03_27_012757 331 13 from from IN 10_1101-2020_03_27_012757 331 14 GEMM GEMM NNP 10_1101-2020_03_27_012757 331 15 expression expression NN 10_1101-2020_03_27_012757 331 16 profiles profile NNS 10_1101-2020_03_27_012757 331 17 were be VBD 10_1101-2020_03_27_012757 331 18 converted convert VBN 10_1101-2020_03_27_012757 331 19 into into IN 10_1101-2020_03_27_012757 331 20 658 658 CD 10_1101-2020_03_27_012757 331 21 their -PRON- PRP$ 10_1101-2020_03_27_012757 331 22 human human JJ 10_1101-2020_03_27_012757 331 23 homologs homolog NNS 10_1101-2020_03_27_012757 331 24 . . . 10_1101-2020_03_27_012757 332 1 The the DT 10_1101-2020_03_27_012757 332 2 query query NN 10_1101-2020_03_27_012757 332 3 samples sample NNS 10_1101-2020_03_27_012757 332 4 were be VBD 10_1101-2020_03_27_012757 332 5 classified classify VBN 10_1101-2020_03_27_012757 332 6 using use VBG 10_1101-2020_03_27_012757 332 7 the the DT 10_1101-2020_03_27_012757 332 8 final final JJ 10_1101-2020_03_27_012757 332 9 CCN ccn NN 10_1101-2020_03_27_012757 332 10 classifier classifier NN 10_1101-2020_03_27_012757 332 11 . . . 10_1101-2020_03_27_012757 333 1 Each each DT 10_1101-2020_03_27_012757 333 2 659 659 CD 10_1101-2020_03_27_012757 333 3 query query NN 10_1101-2020_03_27_012757 333 4 classification classification NN 10_1101-2020_03_27_012757 333 5 profile profile NN 10_1101-2020_03_27_012757 333 6 was be VBD 10_1101-2020_03_27_012757 333 7 labelled label VBN 10_1101-2020_03_27_012757 333 8 as as IN 10_1101-2020_03_27_012757 333 9 one one CD 10_1101-2020_03_27_012757 333 10 of of IN 10_1101-2020_03_27_012757 333 11 the the DT 10_1101-2020_03_27_012757 333 12 four four CD 10_1101-2020_03_27_012757 333 13 classification classification NN 10_1101-2020_03_27_012757 333 14 categories category NNS 10_1101-2020_03_27_012757 333 15 : : : 10_1101-2020_03_27_012757 333 16 “ " `` 10_1101-2020_03_27_012757 333 17 correct correct JJ 10_1101-2020_03_27_012757 333 18 ” " '' 10_1101-2020_03_27_012757 333 19 , , , 10_1101-2020_03_27_012757 333 20 660 660 CD 10_1101-2020_03_27_012757 333 21 “ " `` 10_1101-2020_03_27_012757 333 22 mixed mixed JJ 10_1101-2020_03_27_012757 333 23 ” " '' 10_1101-2020_03_27_012757 333 24 , , , 10_1101-2020_03_27_012757 333 25 “ " `` 10_1101-2020_03_27_012757 333 26 none none NN 10_1101-2020_03_27_012757 333 27 ” " '' 10_1101-2020_03_27_012757 333 28 and and CC 10_1101-2020_03_27_012757 333 29 “ " `` 10_1101-2020_03_27_012757 333 30 other other JJ 10_1101-2020_03_27_012757 333 31 ” " '' 10_1101-2020_03_27_012757 333 32 based base VBN 10_1101-2020_03_27_012757 333 33 on on IN 10_1101-2020_03_27_012757 333 34 classification classification NN 10_1101-2020_03_27_012757 333 35 profiles profile NNS 10_1101-2020_03_27_012757 333 36 . . . 10_1101-2020_03_27_012757 334 1 If if IN 10_1101-2020_03_27_012757 334 2 a a DT 10_1101-2020_03_27_012757 334 3 sample sample NN 10_1101-2020_03_27_012757 334 4 has have VBZ 10_1101-2020_03_27_012757 334 5 a a DT 10_1101-2020_03_27_012757 334 6 CCN CCN NNP 10_1101-2020_03_27_012757 334 7 score score NN 10_1101-2020_03_27_012757 334 8 higher higher RBR 10_1101-2020_03_27_012757 334 9 661 661 CD 10_1101-2020_03_27_012757 334 10 than than IN 10_1101-2020_03_27_012757 334 11 the the DT 10_1101-2020_03_27_012757 334 12 decision decision NN 10_1101-2020_03_27_012757 334 13 threshold threshold NN 10_1101-2020_03_27_012757 334 14 in in IN 10_1101-2020_03_27_012757 334 15 the the DT 10_1101-2020_03_27_012757 334 16 labelled label VBN 10_1101-2020_03_27_012757 334 17 cancer cancer NN 10_1101-2020_03_27_012757 334 18 category category NN 10_1101-2020_03_27_012757 334 19 , , , 10_1101-2020_03_27_012757 334 20 we -PRON- PRP 10_1101-2020_03_27_012757 334 21 assigned assign VBD 10_1101-2020_03_27_012757 334 22 that that IN 10_1101-2020_03_27_012757 334 23 as as IN 10_1101-2020_03_27_012757 334 24 “ " `` 10_1101-2020_03_27_012757 334 25 correct correct JJ 10_1101-2020_03_27_012757 334 26 ” " '' 10_1101-2020_03_27_012757 334 27 . . . 10_1101-2020_03_27_012757 335 1 If if IN 10_1101-2020_03_27_012757 335 2 a a DT 10_1101-2020_03_27_012757 335 3 662 662 CD 10_1101-2020_03_27_012757 335 4 sample sample NN 10_1101-2020_03_27_012757 335 5 has have VBZ 10_1101-2020_03_27_012757 335 6 CCN CCN NNP 10_1101-2020_03_27_012757 335 7 score score VB 10_1101-2020_03_27_012757 335 8 higher high JJR 10_1101-2020_03_27_012757 335 9 than than IN 10_1101-2020_03_27_012757 335 10 the the DT 10_1101-2020_03_27_012757 335 11 decision decision NN 10_1101-2020_03_27_012757 335 12 threshold threshold NN 10_1101-2020_03_27_012757 335 13 in in IN 10_1101-2020_03_27_012757 335 14 labelled label VBN 10_1101-2020_03_27_012757 335 15 cancer cancer NN 10_1101-2020_03_27_012757 335 16 category category NN 10_1101-2020_03_27_012757 335 17 and and CC 10_1101-2020_03_27_012757 335 18 in in IN 10_1101-2020_03_27_012757 335 19 663 663 CD 10_1101-2020_03_27_012757 335 20 other other JJ 10_1101-2020_03_27_012757 335 21 cancer cancer NN 10_1101-2020_03_27_012757 335 22 categories category NNS 10_1101-2020_03_27_012757 335 23 , , , 10_1101-2020_03_27_012757 335 24 we -PRON- PRP 10_1101-2020_03_27_012757 335 25 assigned assign VBD 10_1101-2020_03_27_012757 335 26 that that IN 10_1101-2020_03_27_012757 335 27 as as IN 10_1101-2020_03_27_012757 335 28 “ " `` 10_1101-2020_03_27_012757 335 29 mixed mixed JJ 10_1101-2020_03_27_012757 335 30 ” " '' 10_1101-2020_03_27_012757 335 31 . . . 10_1101-2020_03_27_012757 336 1 If if IN 10_1101-2020_03_27_012757 336 2 a a DT 10_1101-2020_03_27_012757 336 3 sample sample NN 10_1101-2020_03_27_012757 336 4 has have VBZ 10_1101-2020_03_27_012757 336 5 no no DT 10_1101-2020_03_27_012757 336 6 CCN CCN NNP 10_1101-2020_03_27_012757 336 7 score score NN 10_1101-2020_03_27_012757 336 8 higher high JJR 10_1101-2020_03_27_012757 336 9 664 664 CD 10_1101-2020_03_27_012757 336 10 than than IN 10_1101-2020_03_27_012757 336 11 the the DT 10_1101-2020_03_27_012757 336 12 decision decision NN 10_1101-2020_03_27_012757 336 13 threshold threshold NN 10_1101-2020_03_27_012757 336 14 in in IN 10_1101-2020_03_27_012757 336 15 any any DT 10_1101-2020_03_27_012757 336 16 cancer cancer NN 10_1101-2020_03_27_012757 336 17 category category NN 10_1101-2020_03_27_012757 336 18 or or CC 10_1101-2020_03_27_012757 336 19 has have VBZ 10_1101-2020_03_27_012757 336 20 the the DT 10_1101-2020_03_27_012757 336 21 highest high JJS 10_1101-2020_03_27_012757 336 22 CCN CCN NNP 10_1101-2020_03_27_012757 336 23 score score NN 10_1101-2020_03_27_012757 336 24 in in IN 10_1101-2020_03_27_012757 336 25 ‘ ' `` 10_1101-2020_03_27_012757 336 26 Unknown Unknown NNP 10_1101-2020_03_27_012757 336 27 ’ ' '' 10_1101-2020_03_27_012757 336 28 665 665 CD 10_1101-2020_03_27_012757 336 29 category category NN 10_1101-2020_03_27_012757 336 30 , , , 10_1101-2020_03_27_012757 336 31 then then RB 10_1101-2020_03_27_012757 336 32 we -PRON- PRP 10_1101-2020_03_27_012757 336 33 assigned assign VBD 10_1101-2020_03_27_012757 336 34 it -PRON- PRP 10_1101-2020_03_27_012757 336 35 as as IN 10_1101-2020_03_27_012757 336 36 “ " `` 10_1101-2020_03_27_012757 336 37 none none NN 10_1101-2020_03_27_012757 336 38 ” " '' 10_1101-2020_03_27_012757 336 39 . . . 10_1101-2020_03_27_012757 337 1 If if IN 10_1101-2020_03_27_012757 337 2 a a DT 10_1101-2020_03_27_012757 337 3 sample sample NN 10_1101-2020_03_27_012757 337 4 has have VBZ 10_1101-2020_03_27_012757 337 5 CCN CCN NNP 10_1101-2020_03_27_012757 337 6 score score VB 10_1101-2020_03_27_012757 337 7 higher high JJR 10_1101-2020_03_27_012757 337 8 than than IN 10_1101-2020_03_27_012757 337 9 the the DT 10_1101-2020_03_27_012757 337 10 decision decision NN 10_1101-2020_03_27_012757 337 11 666 666 CD 10_1101-2020_03_27_012757 337 12 threshold threshold NN 10_1101-2020_03_27_012757 337 13 in in IN 10_1101-2020_03_27_012757 337 14 a a DT 10_1101-2020_03_27_012757 337 15 cancer cancer NN 10_1101-2020_03_27_012757 337 16 category category NN 10_1101-2020_03_27_012757 337 17 or or CC 10_1101-2020_03_27_012757 337 18 categories category NNS 10_1101-2020_03_27_012757 337 19 not not RB 10_1101-2020_03_27_012757 337 20 including include VBG 10_1101-2020_03_27_012757 337 21 the the DT 10_1101-2020_03_27_012757 337 22 labelled label VBN 10_1101-2020_03_27_012757 337 23 cancer cancer NN 10_1101-2020_03_27_012757 337 24 category category NN 10_1101-2020_03_27_012757 337 25 , , , 10_1101-2020_03_27_012757 337 26 we -PRON- PRP 10_1101-2020_03_27_012757 337 27 667 667 CD 10_1101-2020_03_27_012757 337 28 assigned assign VBD 10_1101-2020_03_27_012757 337 29 it -PRON- PRP 10_1101-2020_03_27_012757 337 30 as as IN 10_1101-2020_03_27_012757 337 31 ” " `` 10_1101-2020_03_27_012757 337 32 other other JJ 10_1101-2020_03_27_012757 337 33 ” " '' 10_1101-2020_03_27_012757 337 34 . . . 10_1101-2020_03_27_012757 338 1 We -PRON- PRP 10_1101-2020_03_27_012757 338 2 analyzed analyze VBD 10_1101-2020_03_27_012757 338 3 and and CC 10_1101-2020_03_27_012757 338 4 visualized visualize VBD 10_1101-2020_03_27_012757 338 5 the the DT 10_1101-2020_03_27_012757 338 6 results result NNS 10_1101-2020_03_27_012757 338 7 using use VBG 10_1101-2020_03_27_012757 338 8 R r NN 10_1101-2020_03_27_012757 338 9 and and CC 10_1101-2020_03_27_012757 338 10 R r NN 10_1101-2020_03_27_012757 338 11 packages package NNS 10_1101-2020_03_27_012757 338 12 668 668 CD 10_1101-2020_03_27_012757 338 13 pheatmap92 pheatmap92 NNPS 10_1101-2020_03_27_012757 338 14 and and CC 10_1101-2020_03_27_012757 338 15 ggplot293 ggplot293 NNP 10_1101-2020_03_27_012757 338 16 . . . 10_1101-2020_03_27_012757 339 1 669 669 CD 10_1101-2020_03_27_012757 339 2 670 670 CD 10_1101-2020_03_27_012757 339 3 Cross Cross NNP 10_1101-2020_03_27_012757 339 4 - - NNP 10_1101-2020_03_27_012757 339 5 Species Species NNP 10_1101-2020_03_27_012757 339 6 Assessment Assessment NNP 10_1101-2020_03_27_012757 339 7 671 671 CD 10_1101-2020_03_27_012757 339 8 To to TO 10_1101-2020_03_27_012757 339 9 assess assess VB 10_1101-2020_03_27_012757 339 10 the the DT 10_1101-2020_03_27_012757 339 11 performance performance NN 10_1101-2020_03_27_012757 339 12 of of IN 10_1101-2020_03_27_012757 339 13 cross cross JJ 10_1101-2020_03_27_012757 339 14 - - JJ 10_1101-2020_03_27_012757 339 15 species species JJ 10_1101-2020_03_27_012757 339 16 classification classification NN 10_1101-2020_03_27_012757 339 17 , , , 10_1101-2020_03_27_012757 339 18 we -PRON- PRP 10_1101-2020_03_27_012757 339 19 downloaded download VBD 10_1101-2020_03_27_012757 339 20 1003 1003 CD 10_1101-2020_03_27_012757 339 21 672 672 CD 10_1101-2020_03_27_012757 339 22 labelled label VBD 10_1101-2020_03_27_012757 339 23 human human JJ 10_1101-2020_03_27_012757 339 24 tissue tissue NN 10_1101-2020_03_27_012757 339 25 / / SYM 10_1101-2020_03_27_012757 339 26 cell cell NN 10_1101-2020_03_27_012757 339 27 type type NN 10_1101-2020_03_27_012757 339 28 and and CC 10_1101-2020_03_27_012757 339 29 1993 1993 CD 10_1101-2020_03_27_012757 339 30 labelled label VBN 10_1101-2020_03_27_012757 339 31 mouse mouse NN 10_1101-2020_03_27_012757 339 32 tissue tissue NN 10_1101-2020_03_27_012757 339 33 / / SYM 10_1101-2020_03_27_012757 339 34 cell cell NN 10_1101-2020_03_27_012757 339 35 type type NN 10_1101-2020_03_27_012757 339 36 RNA RNA NNP 10_1101-2020_03_27_012757 339 37 - - HYPH 10_1101-2020_03_27_012757 339 38 seq seq NN 10_1101-2020_03_27_012757 339 39 expression expression NN 10_1101-2020_03_27_012757 339 40 673 673 CD 10_1101-2020_03_27_012757 339 41 profiles profile NNS 10_1101-2020_03_27_012757 339 42 from from IN 10_1101-2020_03_27_012757 339 43 Github Github NNP 10_1101-2020_03_27_012757 339 44 ( ( -LRB- 10_1101-2020_03_27_012757 339 45 https://github.com/pcahan1/CellNet https://github.com/pcahan1/CellNet NNP 10_1101-2020_03_27_012757 339 46 ) ) -RRB- 10_1101-2020_03_27_012757 339 47 . . . 10_1101-2020_03_27_012757 340 1 We -PRON- PRP 10_1101-2020_03_27_012757 340 2 first first RB 10_1101-2020_03_27_012757 340 3 converted convert VBD 10_1101-2020_03_27_012757 340 4 the the DT 10_1101-2020_03_27_012757 340 5 mouse mouse NN 10_1101-2020_03_27_012757 340 6 genes gene VBZ 10_1101-2020_03_27_012757 340 7 674 674 CD 10_1101-2020_03_27_012757 340 8 into into IN 10_1101-2020_03_27_012757 340 9 human human JJ 10_1101-2020_03_27_012757 340 10 homologous homologous JJ 10_1101-2020_03_27_012757 340 11 genes gene NNS 10_1101-2020_03_27_012757 340 12 . . . 10_1101-2020_03_27_012757 341 1 Then then RB 10_1101-2020_03_27_012757 341 2 we -PRON- PRP 10_1101-2020_03_27_012757 341 3 found find VBD 10_1101-2020_03_27_012757 341 4 the the DT 10_1101-2020_03_27_012757 341 5 intersecting intersect VBG 10_1101-2020_03_27_012757 341 6 genes gene NNS 10_1101-2020_03_27_012757 341 7 between between IN 10_1101-2020_03_27_012757 341 8 mouse mouse NN 10_1101-2020_03_27_012757 341 9 675 675 CD 10_1101-2020_03_27_012757 341 10 tissue tissue NN 10_1101-2020_03_27_012757 341 11 / / SYM 10_1101-2020_03_27_012757 341 12 cell cell NN 10_1101-2020_03_27_012757 341 13 expression expression NN 10_1101-2020_03_27_012757 341 14 profiles profile NNS 10_1101-2020_03_27_012757 341 15 and and CC 10_1101-2020_03_27_012757 341 16 human human JJ 10_1101-2020_03_27_012757 341 17 tissue tissue NN 10_1101-2020_03_27_012757 341 18 / / SYM 10_1101-2020_03_27_012757 341 19 cell cell NN 10_1101-2020_03_27_012757 341 20 expression expression NN 10_1101-2020_03_27_012757 341 21 profiles profile NNS 10_1101-2020_03_27_012757 341 22 . . . 10_1101-2020_03_27_012757 342 1 Limiting limit VBG 10_1101-2020_03_27_012757 342 2 the the DT 10_1101-2020_03_27_012757 342 3 input input NN 10_1101-2020_03_27_012757 342 4 of of IN 10_1101-2020_03_27_012757 342 5 676 676 CD 10_1101-2020_03_27_012757 342 6 human human JJ 10_1101-2020_03_27_012757 342 7 tissue tissue NN 10_1101-2020_03_27_012757 342 8 RNA RNA NNP 10_1101-2020_03_27_012757 342 9 - - HYPH 10_1101-2020_03_27_012757 342 10 seq seq NN 10_1101-2020_03_27_012757 342 11 profiles profile NNS 10_1101-2020_03_27_012757 342 12 to to IN 10_1101-2020_03_27_012757 342 13 the the DT 10_1101-2020_03_27_012757 342 14 intersecting intersect VBG 10_1101-2020_03_27_012757 342 15 genes gene NNS 10_1101-2020_03_27_012757 342 16 , , , 10_1101-2020_03_27_012757 342 17 we -PRON- PRP 10_1101-2020_03_27_012757 342 18 trained train VBD 10_1101-2020_03_27_012757 342 19 a a DT 10_1101-2020_03_27_012757 342 20 CCN CCN NNP 10_1101-2020_03_27_012757 342 21 classifier classifier NN 10_1101-2020_03_27_012757 342 22 with with IN 10_1101-2020_03_27_012757 342 23 all all DT 10_1101-2020_03_27_012757 342 24 677 677 CD 10_1101-2020_03_27_012757 342 25 the the DT 10_1101-2020_03_27_012757 342 26 human human JJ 10_1101-2020_03_27_012757 342 27 tissue tissue NN 10_1101-2020_03_27_012757 342 28 / / SYM 10_1101-2020_03_27_012757 342 29 cell cell NN 10_1101-2020_03_27_012757 342 30 expression expression NN 10_1101-2020_03_27_012757 342 31 profiles profile NNS 10_1101-2020_03_27_012757 342 32 . . . 10_1101-2020_03_27_012757 343 1 The the DT 10_1101-2020_03_27_012757 343 2 parameters parameter NNS 10_1101-2020_03_27_012757 343 3 used use VBD 10_1101-2020_03_27_012757 343 4 for for IN 10_1101-2020_03_27_012757 343 5 the the DT 10_1101-2020_03_27_012757 343 6 function function NN 10_1101-2020_03_27_012757 343 7 678 678 CD 10_1101-2020_03_27_012757 343 8 “ " `` 10_1101-2020_03_27_012757 343 9 broadClass_train broadclass_train NN 10_1101-2020_03_27_012757 343 10 ” " '' 10_1101-2020_03_27_012757 343 11 in in IN 10_1101-2020_03_27_012757 343 12 the the DT 10_1101-2020_03_27_012757 343 13 package package NN 10_1101-2020_03_27_012757 343 14 cancerCellNet cancerCellNet NNS 10_1101-2020_03_27_012757 343 15 are be VBP 10_1101-2020_03_27_012757 343 16 in in IN 10_1101-2020_03_27_012757 343 17 Supp Supp NNP 10_1101-2020_03_27_012757 343 18 Tab Tab NNP 10_1101-2020_03_27_012757 343 19 9 9 CD 10_1101-2020_03_27_012757 343 20 . . . 10_1101-2020_03_27_012757 344 1 We -PRON- PRP 10_1101-2020_03_27_012757 344 2 randomly randomly RB 10_1101-2020_03_27_012757 344 3 sampled sample VBD 10_1101-2020_03_27_012757 344 4 75 75 CD 10_1101-2020_03_27_012757 344 5 679 679 CD 10_1101-2020_03_27_012757 344 6 .CC .CC NFP 10_1101-2020_03_27_012757 344 7 - - HYPH 10_1101-2020_03_27_012757 344 8 BY by IN 10_1101-2020_03_27_012757 344 9 - - HYPH 10_1101-2020_03_27_012757 344 10 NC NC NNP 10_1101-2020_03_27_012757 344 11 - - HYPH 10_1101-2020_03_27_012757 344 12 ND ND NNP 10_1101-2020_03_27_012757 344 13 4.0 4.0 CD 10_1101-2020_03_27_012757 344 14 International International NNP 10_1101-2020_03_27_012757 344 15 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 344 16 under under IN 10_1101-2020_03_27_012757 344 17 a a DT 10_1101-2020_03_27_012757 344 18 ( ( -LRB- 10_1101-2020_03_27_012757 344 19 which which WDT 10_1101-2020_03_27_012757 344 20 was be VBD 10_1101-2020_03_27_012757 344 21 not not RB 10_1101-2020_03_27_012757 344 22 certified certify VBN 10_1101-2020_03_27_012757 344 23 by by IN 10_1101-2020_03_27_012757 344 24 peer peer NN 10_1101-2020_03_27_012757 344 25 review review NN 10_1101-2020_03_27_012757 344 26 ) ) -RRB- 10_1101-2020_03_27_012757 344 27 is be VBZ 10_1101-2020_03_27_012757 344 28 the the DT 10_1101-2020_03_27_012757 344 29 author author NN 10_1101-2020_03_27_012757 344 30 / / SYM 10_1101-2020_03_27_012757 344 31 funder funder NN 10_1101-2020_03_27_012757 344 32 , , , 10_1101-2020_03_27_012757 344 33 who who WP 10_1101-2020_03_27_012757 344 34 has have VBZ 10_1101-2020_03_27_012757 344 35 granted grant VBN 10_1101-2020_03_27_012757 344 36 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 344 37 a a DT 10_1101-2020_03_27_012757 344 38 license license NN 10_1101-2020_03_27_012757 344 39 to to TO 10_1101-2020_03_27_012757 344 40 display display VB 10_1101-2020_03_27_012757 344 41 the the DT 10_1101-2020_03_27_012757 344 42 preprint preprint NN 10_1101-2020_03_27_012757 344 43 in in IN 10_1101-2020_03_27_012757 344 44 perpetuity perpetuity NN 10_1101-2020_03_27_012757 344 45 . . . 10_1101-2020_03_27_012757 345 1 It -PRON- PRP 10_1101-2020_03_27_012757 345 2 is be VBZ 10_1101-2020_03_27_012757 345 3 made make VBN 10_1101-2020_03_27_012757 345 4 The the DT 10_1101-2020_03_27_012757 345 5 copyright copyright NN 10_1101-2020_03_27_012757 345 6 holder holder NN 10_1101-2020_03_27_012757 345 7 for for IN 10_1101-2020_03_27_012757 345 8 this this DT 10_1101-2020_03_27_012757 345 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 345 10 version version NN 10_1101-2020_03_27_012757 345 11 posted post VBD 10_1101-2020_03_27_012757 345 12 January January NNP 10_1101-2020_03_27_012757 345 13 9 9 CD 10_1101-2020_03_27_012757 345 14 , , , 10_1101-2020_03_27_012757 345 15 2021 2021 CD 10_1101-2020_03_27_012757 345 16 . . . 10_1101-2020_03_27_012757 345 17 ; ; : 10_1101-2020_03_27_012757 345 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 345 19 : : : 10_1101-2020_03_27_012757 345 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 345 21 preprint preprint NN 10_1101-2020_03_27_012757 345 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 345 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 345 24 26 26 CD 10_1101-2020_03_27_012757 345 25 samples sample NNS 10_1101-2020_03_27_012757 345 26 from from IN 10_1101-2020_03_27_012757 345 27 each each DT 10_1101-2020_03_27_012757 345 28 tissue tissue NN 10_1101-2020_03_27_012757 345 29 category category NN 10_1101-2020_03_27_012757 345 30 in in IN 10_1101-2020_03_27_012757 345 31 mouse mouse NN 10_1101-2020_03_27_012757 345 32 tissue tissue NN 10_1101-2020_03_27_012757 345 33 / / SYM 10_1101-2020_03_27_012757 345 34 cell cell NN 10_1101-2020_03_27_012757 345 35 data datum NNS 10_1101-2020_03_27_012757 345 36 and and CC 10_1101-2020_03_27_012757 345 37 applied apply VBD 10_1101-2020_03_27_012757 345 38 the the DT 10_1101-2020_03_27_012757 345 39 classifier classifier NN 10_1101-2020_03_27_012757 345 40 on on IN 10_1101-2020_03_27_012757 345 41 those those DT 10_1101-2020_03_27_012757 345 42 680 680 CD 10_1101-2020_03_27_012757 345 43 samples sample NNS 10_1101-2020_03_27_012757 345 44 to to TO 10_1101-2020_03_27_012757 345 45 assess assess VB 10_1101-2020_03_27_012757 345 46 performance performance NN 10_1101-2020_03_27_012757 345 47 . . . 10_1101-2020_03_27_012757 346 1 681 681 CD 10_1101-2020_03_27_012757 346 2 682 682 CD 10_1101-2020_03_27_012757 346 3 Cross Cross NNP 10_1101-2020_03_27_012757 346 4 - - NNP 10_1101-2020_03_27_012757 346 5 Technology Technology NNP 10_1101-2020_03_27_012757 346 6 Assessment Assessment NNP 10_1101-2020_03_27_012757 346 7 683 683 CD 10_1101-2020_03_27_012757 346 8 To to TO 10_1101-2020_03_27_012757 346 9 assess assess VB 10_1101-2020_03_27_012757 346 10 the the DT 10_1101-2020_03_27_012757 346 11 performance performance NN 10_1101-2020_03_27_012757 346 12 of of IN 10_1101-2020_03_27_012757 346 13 CCN CCN NNP 10_1101-2020_03_27_012757 346 14 in in IN 10_1101-2020_03_27_012757 346 15 applications application NNS 10_1101-2020_03_27_012757 346 16 to to IN 10_1101-2020_03_27_012757 346 17 microarray microarray JJ 10_1101-2020_03_27_012757 346 18 data datum NNS 10_1101-2020_03_27_012757 346 19 , , , 10_1101-2020_03_27_012757 346 20 we -PRON- PRP 10_1101-2020_03_27_012757 346 21 gathered gather VBD 10_1101-2020_03_27_012757 346 22 684 684 CD 10_1101-2020_03_27_012757 346 23 6,219 6,219 CD 10_1101-2020_03_27_012757 346 24 patient patient JJ 10_1101-2020_03_27_012757 346 25 tumor tumor NN 10_1101-2020_03_27_012757 346 26 microarray microarray NN 10_1101-2020_03_27_012757 346 27 profiles profile NNS 10_1101-2020_03_27_012757 346 28 across across IN 10_1101-2020_03_27_012757 346 29 12 12 CD 10_1101-2020_03_27_012757 346 30 different different JJ 10_1101-2020_03_27_012757 346 31 cancer cancer NN 10_1101-2020_03_27_012757 346 32 types type NNS 10_1101-2020_03_27_012757 346 33 from from IN 10_1101-2020_03_27_012757 346 34 more more JJR 10_1101-2020_03_27_012757 346 35 than than IN 10_1101-2020_03_27_012757 346 36 100 100 CD 10_1101-2020_03_27_012757 346 37 685 685 CD 10_1101-2020_03_27_012757 346 38 different different JJ 10_1101-2020_03_27_012757 346 39 projects project NNS 10_1101-2020_03_27_012757 346 40 ( ( -LRB- 10_1101-2020_03_27_012757 346 41 Supp Supp NNP 10_1101-2020_03_27_012757 346 42 Tab Tab NNP 10_1101-2020_03_27_012757 346 43 12 12 CD 10_1101-2020_03_27_012757 346 44 ) ) -RRB- 10_1101-2020_03_27_012757 346 45 . . . 10_1101-2020_03_27_012757 347 1 We -PRON- PRP 10_1101-2020_03_27_012757 347 2 found find VBD 10_1101-2020_03_27_012757 347 3 the the DT 10_1101-2020_03_27_012757 347 4 intersecting intersect VBG 10_1101-2020_03_27_012757 347 5 genes gene NNS 10_1101-2020_03_27_012757 347 6 between between IN 10_1101-2020_03_27_012757 347 7 the the DT 10_1101-2020_03_27_012757 347 8 microarray microarray JJ 10_1101-2020_03_27_012757 347 9 686 686 CD 10_1101-2020_03_27_012757 347 10 profiles profile NNS 10_1101-2020_03_27_012757 347 11 and and CC 10_1101-2020_03_27_012757 347 12 TCGA tcga NN 10_1101-2020_03_27_012757 347 13 patient patient NN 10_1101-2020_03_27_012757 347 14 RNA RNA NNP 10_1101-2020_03_27_012757 347 15 - - HYPH 10_1101-2020_03_27_012757 347 16 seq seq NN 10_1101-2020_03_27_012757 347 17 profiles profile NNS 10_1101-2020_03_27_012757 347 18 . . . 10_1101-2020_03_27_012757 348 1 Limiting limit VBG 10_1101-2020_03_27_012757 348 2 the the DT 10_1101-2020_03_27_012757 348 3 input input NN 10_1101-2020_03_27_012757 348 4 of of IN 10_1101-2020_03_27_012757 348 5 RNA RNA NNP 10_1101-2020_03_27_012757 348 6 - - HYPH 10_1101-2020_03_27_012757 348 7 seq seq NN 10_1101-2020_03_27_012757 348 8 profiles profile NNS 10_1101-2020_03_27_012757 348 9 to to IN 10_1101-2020_03_27_012757 348 10 the the DT 10_1101-2020_03_27_012757 348 11 687 687 CD 10_1101-2020_03_27_012757 348 12 intersecting intersect VBG 10_1101-2020_03_27_012757 348 13 genes gene NNS 10_1101-2020_03_27_012757 348 14 , , , 10_1101-2020_03_27_012757 348 15 we -PRON- PRP 10_1101-2020_03_27_012757 348 16 created create VBD 10_1101-2020_03_27_012757 348 17 a a DT 10_1101-2020_03_27_012757 348 18 CCN ccn NN 10_1101-2020_03_27_012757 348 19 classifier classifier NN 10_1101-2020_03_27_012757 348 20 with with IN 10_1101-2020_03_27_012757 348 21 all all PDT 10_1101-2020_03_27_012757 348 22 the the DT 10_1101-2020_03_27_012757 348 23 TCGA TCGA NNP 10_1101-2020_03_27_012757 348 24 patient patient NN 10_1101-2020_03_27_012757 348 25 profiles profile NNS 10_1101-2020_03_27_012757 348 26 using use VBG 10_1101-2020_03_27_012757 348 27 688 688 CD 10_1101-2020_03_27_012757 348 28 parameters parameter NNS 10_1101-2020_03_27_012757 348 29 for for IN 10_1101-2020_03_27_012757 348 30 the the DT 10_1101-2020_03_27_012757 348 31 function function NN 10_1101-2020_03_27_012757 348 32 “ " `` 10_1101-2020_03_27_012757 348 33 broadClass_train broadclass_train NN 10_1101-2020_03_27_012757 348 34 ” " '' 10_1101-2020_03_27_012757 348 35 listed list VBN 10_1101-2020_03_27_012757 348 36 in in IN 10_1101-2020_03_27_012757 348 37 Supp Supp NNP 10_1101-2020_03_27_012757 348 38 Tab Tab NNP 10_1101-2020_03_27_012757 348 39 9 9 CD 10_1101-2020_03_27_012757 348 40 . . . 10_1101-2020_03_27_012757 349 1 After after IN 10_1101-2020_03_27_012757 349 2 the the DT 10_1101-2020_03_27_012757 349 3 microarray microarray JJ 10_1101-2020_03_27_012757 349 4 689 689 CD 10_1101-2020_03_27_012757 349 5 specific specific JJ 10_1101-2020_03_27_012757 349 6 classifier classifier NN 10_1101-2020_03_27_012757 349 7 was be VBD 10_1101-2020_03_27_012757 349 8 trained train VBN 10_1101-2020_03_27_012757 349 9 , , , 10_1101-2020_03_27_012757 349 10 we -PRON- PRP 10_1101-2020_03_27_012757 349 11 randomly randomly RB 10_1101-2020_03_27_012757 349 12 sampled sample VBD 10_1101-2020_03_27_012757 349 13 60 60 CD 10_1101-2020_03_27_012757 349 14 microarray microarray JJ 10_1101-2020_03_27_012757 349 15 patient patient NN 10_1101-2020_03_27_012757 349 16 samples sample NNS 10_1101-2020_03_27_012757 349 17 from from IN 10_1101-2020_03_27_012757 349 18 each each DT 10_1101-2020_03_27_012757 349 19 690 690 CD 10_1101-2020_03_27_012757 349 20 cancer cancer NN 10_1101-2020_03_27_012757 349 21 category category NN 10_1101-2020_03_27_012757 349 22 and and CC 10_1101-2020_03_27_012757 349 23 applied applied JJ 10_1101-2020_03_27_012757 349 24 CCN CCN NNP 10_1101-2020_03_27_012757 349 25 classifier classifier NN 10_1101-2020_03_27_012757 349 26 on on IN 10_1101-2020_03_27_012757 349 27 them -PRON- PRP 10_1101-2020_03_27_012757 349 28 as as IN 10_1101-2020_03_27_012757 349 29 assessment assessment NN 10_1101-2020_03_27_012757 349 30 of of IN 10_1101-2020_03_27_012757 349 31 the the DT 10_1101-2020_03_27_012757 349 32 cross cross JJ 10_1101-2020_03_27_012757 349 33 - - NN 10_1101-2020_03_27_012757 349 34 technology technology NN 10_1101-2020_03_27_012757 349 35 691 691 CD 10_1101-2020_03_27_012757 349 36 performance performance NN 10_1101-2020_03_27_012757 349 37 in in IN 10_1101-2020_03_27_012757 349 38 Supp Supp NNP 10_1101-2020_03_27_012757 349 39 Fig Fig NNP 10_1101-2020_03_27_012757 349 40 2A. 2a. CD 10_1101-2020_03_27_012757 350 1 The the DT 10_1101-2020_03_27_012757 350 2 same same JJ 10_1101-2020_03_27_012757 350 3 CCN ccn NN 10_1101-2020_03_27_012757 350 4 classifier classifier NN 10_1101-2020_03_27_012757 350 5 was be VBD 10_1101-2020_03_27_012757 350 6 used use VBN 10_1101-2020_03_27_012757 350 7 to to TO 10_1101-2020_03_27_012757 350 8 assess assess VB 10_1101-2020_03_27_012757 350 9 microarray microarray NNP 10_1101-2020_03_27_012757 350 10 CCL CCL NNP 10_1101-2020_03_27_012757 350 11 692 692 CD 10_1101-2020_03_27_012757 350 12 samples sample NNS 10_1101-2020_03_27_012757 350 13 Supp Supp NNP 10_1101-2020_03_27_012757 350 14 Fig Fig NNP 10_1101-2020_03_27_012757 350 15 2B. 2b. CD 10_1101-2020_03_27_012757 351 1 693 693 CD 10_1101-2020_03_27_012757 351 2 694 694 CD 10_1101-2020_03_27_012757 351 3 Training training NN 10_1101-2020_03_27_012757 351 4 and and CC 10_1101-2020_03_27_012757 351 5 validating validate VBG 10_1101-2020_03_27_012757 351 6 scRNA scRNA NNP 10_1101-2020_03_27_012757 351 7 - - HYPH 10_1101-2020_03_27_012757 351 8 seq seq NN 10_1101-2020_03_27_012757 351 9 Classifier Classifier NNP 10_1101-2020_03_27_012757 351 10 695 695 CD 10_1101-2020_03_27_012757 351 11 We -PRON- PRP 10_1101-2020_03_27_012757 351 12 extracted extract VBD 10_1101-2020_03_27_012757 351 13 labelled label VBN 10_1101-2020_03_27_012757 351 14 human human JJ 10_1101-2020_03_27_012757 351 15 melanoma melanoma NNP 10_1101-2020_03_27_012757 351 16 and and CC 10_1101-2020_03_27_012757 351 17 glioblastoma glioblastoma NNP 10_1101-2020_03_27_012757 351 18 scRNA scRNA NNP 10_1101-2020_03_27_012757 351 19 - - HYPH 10_1101-2020_03_27_012757 351 20 seq seq NN 10_1101-2020_03_27_012757 351 21 expression expression NN 10_1101-2020_03_27_012757 351 22 696 696 CD 10_1101-2020_03_27_012757 351 23 profiles40,41 profiles40,41 NNS 10_1101-2020_03_27_012757 351 24 , , , 10_1101-2020_03_27_012757 351 25 and and CC 10_1101-2020_03_27_012757 351 26 compiled compile VBD 10_1101-2020_03_27_012757 351 27 the the DT 10_1101-2020_03_27_012757 351 28 two two CD 10_1101-2020_03_27_012757 351 29 datasets dataset NNS 10_1101-2020_03_27_012757 351 30 excluding exclude VBG 10_1101-2020_03_27_012757 351 31 3 3 CD 10_1101-2020_03_27_012757 351 32 cell cell NN 10_1101-2020_03_27_012757 351 33 types type NNS 10_1101-2020_03_27_012757 351 34 T.CD4 t.cd4 JJ 10_1101-2020_03_27_012757 351 35 , , , 10_1101-2020_03_27_012757 351 36 T.CD8 T.CD8 NNP 10_1101-2020_03_27_012757 351 37 and and CC 10_1101-2020_03_27_012757 351 38 Myeloid Myeloid NNP 10_1101-2020_03_27_012757 351 39 697 697 CD 10_1101-2020_03_27_012757 351 40 due due IN 10_1101-2020_03_27_012757 351 41 to to IN 10_1101-2020_03_27_012757 351 42 low low JJ 10_1101-2020_03_27_012757 351 43 number number NN 10_1101-2020_03_27_012757 351 44 of of IN 10_1101-2020_03_27_012757 351 45 cells cell NNS 10_1101-2020_03_27_012757 351 46 for for IN 10_1101-2020_03_27_012757 351 47 training training NN 10_1101-2020_03_27_012757 351 48 . . . 10_1101-2020_03_27_012757 352 1 60 60 CD 10_1101-2020_03_27_012757 352 2 cells cell NNS 10_1101-2020_03_27_012757 352 3 from from IN 10_1101-2020_03_27_012757 352 4 each each DT 10_1101-2020_03_27_012757 352 5 of of IN 10_1101-2020_03_27_012757 352 6 the the DT 10_1101-2020_03_27_012757 352 7 11 11 CD 10_1101-2020_03_27_012757 352 8 cell cell NN 10_1101-2020_03_27_012757 352 9 types type NNS 10_1101-2020_03_27_012757 352 10 were be VBD 10_1101-2020_03_27_012757 352 11 sampled sample VBN 10_1101-2020_03_27_012757 352 12 for for IN 10_1101-2020_03_27_012757 352 13 698 698 CD 10_1101-2020_03_27_012757 352 14 training training NN 10_1101-2020_03_27_012757 352 15 a a DT 10_1101-2020_03_27_012757 352 16 scRNA scrna CD 10_1101-2020_03_27_012757 352 17 - - HYPH 10_1101-2020_03_27_012757 352 18 seq seq NN 10_1101-2020_03_27_012757 352 19 classifier classifier NN 10_1101-2020_03_27_012757 352 20 . . . 10_1101-2020_03_27_012757 353 1 The the DT 10_1101-2020_03_27_012757 353 2 parameters parameter NNS 10_1101-2020_03_27_012757 353 3 for for IN 10_1101-2020_03_27_012757 353 4 training train VBG 10_1101-2020_03_27_012757 353 5 a a DT 10_1101-2020_03_27_012757 353 6 general general JJ 10_1101-2020_03_27_012757 353 7 scRNA scrna JJ 10_1101-2020_03_27_012757 353 8 - - HYPH 10_1101-2020_03_27_012757 353 9 seq seq NN 10_1101-2020_03_27_012757 353 10 classifier classifier NN 10_1101-2020_03_27_012757 353 11 699 699 CD 10_1101-2020_03_27_012757 353 12 using use VBG 10_1101-2020_03_27_012757 353 13 the the DT 10_1101-2020_03_27_012757 353 14 function function NN 10_1101-2020_03_27_012757 353 15 “ " `` 10_1101-2020_03_27_012757 353 16 broadClass_train broadclass_train NN 10_1101-2020_03_27_012757 353 17 ” " '' 10_1101-2020_03_27_012757 353 18 are be VBP 10_1101-2020_03_27_012757 353 19 in in IN 10_1101-2020_03_27_012757 353 20 Supp Supp NNP 10_1101-2020_03_27_012757 353 21 Tab Tab NNP 10_1101-2020_03_27_012757 353 22 9 9 CD 10_1101-2020_03_27_012757 353 23 . . . 10_1101-2020_03_27_012757 354 1 25 25 CD 10_1101-2020_03_27_012757 354 2 cells cell NNS 10_1101-2020_03_27_012757 354 3 from from IN 10_1101-2020_03_27_012757 354 4 each each DT 10_1101-2020_03_27_012757 354 5 of of IN 10_1101-2020_03_27_012757 354 6 the the DT 10_1101-2020_03_27_012757 354 7 11 11 CD 10_1101-2020_03_27_012757 354 8 cell cell NN 10_1101-2020_03_27_012757 354 9 types type NNS 10_1101-2020_03_27_012757 354 10 700 700 CD 10_1101-2020_03_27_012757 354 11 from from IN 10_1101-2020_03_27_012757 354 12 the the DT 10_1101-2020_03_27_012757 354 13 held hold VBN 10_1101-2020_03_27_012757 354 14 - - HYPH 10_1101-2020_03_27_012757 354 15 out out RP 10_1101-2020_03_27_012757 354 16 data datum NNS 10_1101-2020_03_27_012757 354 17 were be VBD 10_1101-2020_03_27_012757 354 18 selected select VBN 10_1101-2020_03_27_012757 354 19 to to TO 10_1101-2020_03_27_012757 354 20 assess assess VB 10_1101-2020_03_27_012757 354 21 the the DT 10_1101-2020_03_27_012757 354 22 single single JJ 10_1101-2020_03_27_012757 354 23 cell cell NN 10_1101-2020_03_27_012757 354 24 classifier classifier NN 10_1101-2020_03_27_012757 354 25 . . . 10_1101-2020_03_27_012757 355 1 Using use VBG 10_1101-2020_03_27_012757 355 2 maximization maximization NN 10_1101-2020_03_27_012757 355 3 of of IN 10_1101-2020_03_27_012757 355 4 701 701 CD 10_1101-2020_03_27_012757 355 5 average average JJ 10_1101-2020_03_27_012757 355 6 Macro Macro NNP 10_1101-2020_03_27_012757 355 7 F1 F1 NNP 10_1101-2020_03_27_012757 355 8 measure measure NN 10_1101-2020_03_27_012757 355 9 , , , 10_1101-2020_03_27_012757 355 10 we -PRON- PRP 10_1101-2020_03_27_012757 355 11 selected select VBD 10_1101-2020_03_27_012757 355 12 the the DT 10_1101-2020_03_27_012757 355 13 decision decision NN 10_1101-2020_03_27_012757 355 14 threshold threshold NN 10_1101-2020_03_27_012757 355 15 of of IN 10_1101-2020_03_27_012757 355 16 0.255 0.255 CD 10_1101-2020_03_27_012757 355 17 . . . 10_1101-2020_03_27_012757 356 1 The the DT 10_1101-2020_03_27_012757 356 2 gene gene NN 10_1101-2020_03_27_012757 356 3 - - HYPH 10_1101-2020_03_27_012757 356 4 pairs pair NNS 10_1101-2020_03_27_012757 356 5 that that WDT 10_1101-2020_03_27_012757 356 6 702 702 CD 10_1101-2020_03_27_012757 356 7 were be VBD 10_1101-2020_03_27_012757 356 8 selected select VBN 10_1101-2020_03_27_012757 356 9 to to TO 10_1101-2020_03_27_012757 356 10 construct construct VB 10_1101-2020_03_27_012757 356 11 the the DT 10_1101-2020_03_27_012757 356 12 classifier classifier NN 10_1101-2020_03_27_012757 356 13 are be VBP 10_1101-2020_03_27_012757 356 14 in in IN 10_1101-2020_03_27_012757 356 15 Supp Supp NNP 10_1101-2020_03_27_012757 356 16 Tab Tab NNP 10_1101-2020_03_27_012757 356 17 10 10 CD 10_1101-2020_03_27_012757 356 18 . . . 10_1101-2020_03_27_012757 357 1 To to TO 10_1101-2020_03_27_012757 357 2 assess assess VB 10_1101-2020_03_27_012757 357 3 the the DT 10_1101-2020_03_27_012757 357 4 cross cross NN 10_1101-2020_03_27_012757 357 5 - - NN 10_1101-2020_03_27_012757 357 6 technology technology NN 10_1101-2020_03_27_012757 357 7 703 703 CD 10_1101-2020_03_27_012757 357 8 capability capability NN 10_1101-2020_03_27_012757 357 9 of of IN 10_1101-2020_03_27_012757 357 10 applying apply VBG 10_1101-2020_03_27_012757 357 11 scRNA scRNA NNP 10_1101-2020_03_27_012757 357 12 - - HYPH 10_1101-2020_03_27_012757 357 13 seq seq NN 10_1101-2020_03_27_012757 357 14 classifier classifier NN 10_1101-2020_03_27_012757 357 15 to to TO 10_1101-2020_03_27_012757 357 16 bulk bulk NNP 10_1101-2020_03_27_012757 357 17 RNA RNA NNP 10_1101-2020_03_27_012757 357 18 - - HYPH 10_1101-2020_03_27_012757 357 19 seq seq NN 10_1101-2020_03_27_012757 357 20 , , , 10_1101-2020_03_27_012757 357 21 we -PRON- PRP 10_1101-2020_03_27_012757 357 22 downloaded download VBD 10_1101-2020_03_27_012757 357 23 305 305 CD 10_1101-2020_03_27_012757 357 24 expression expression NN 10_1101-2020_03_27_012757 357 25 704 704 CD 10_1101-2020_03_27_012757 357 26 .CC .CC , 10_1101-2020_03_27_012757 357 27 - - HYPH 10_1101-2020_03_27_012757 357 28 BY by IN 10_1101-2020_03_27_012757 357 29 - - HYPH 10_1101-2020_03_27_012757 357 30 NC NC NNP 10_1101-2020_03_27_012757 357 31 - - HYPH 10_1101-2020_03_27_012757 357 32 ND ND NNP 10_1101-2020_03_27_012757 357 33 4.0 4.0 CD 10_1101-2020_03_27_012757 357 34 International International NNP 10_1101-2020_03_27_012757 357 35 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 357 36 under under IN 10_1101-2020_03_27_012757 357 37 a a DT 10_1101-2020_03_27_012757 357 38 ( ( -LRB- 10_1101-2020_03_27_012757 357 39 which which WDT 10_1101-2020_03_27_012757 357 40 was be VBD 10_1101-2020_03_27_012757 357 41 not not RB 10_1101-2020_03_27_012757 357 42 certified certify VBN 10_1101-2020_03_27_012757 357 43 by by IN 10_1101-2020_03_27_012757 357 44 peer peer NN 10_1101-2020_03_27_012757 357 45 review review NN 10_1101-2020_03_27_012757 357 46 ) ) -RRB- 10_1101-2020_03_27_012757 357 47 is be VBZ 10_1101-2020_03_27_012757 357 48 the the DT 10_1101-2020_03_27_012757 357 49 author author NN 10_1101-2020_03_27_012757 357 50 / / SYM 10_1101-2020_03_27_012757 357 51 funder funder NN 10_1101-2020_03_27_012757 357 52 , , , 10_1101-2020_03_27_012757 357 53 who who WP 10_1101-2020_03_27_012757 357 54 has have VBZ 10_1101-2020_03_27_012757 357 55 granted grant VBN 10_1101-2020_03_27_012757 357 56 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 357 57 a a DT 10_1101-2020_03_27_012757 357 58 license license NN 10_1101-2020_03_27_012757 357 59 to to TO 10_1101-2020_03_27_012757 357 60 display display VB 10_1101-2020_03_27_012757 357 61 the the DT 10_1101-2020_03_27_012757 357 62 preprint preprint NN 10_1101-2020_03_27_012757 357 63 in in IN 10_1101-2020_03_27_012757 357 64 perpetuity perpetuity NN 10_1101-2020_03_27_012757 357 65 . . . 10_1101-2020_03_27_012757 358 1 It -PRON- PRP 10_1101-2020_03_27_012757 358 2 is be VBZ 10_1101-2020_03_27_012757 358 3 made make VBN 10_1101-2020_03_27_012757 358 4 The the DT 10_1101-2020_03_27_012757 358 5 copyright copyright NN 10_1101-2020_03_27_012757 358 6 holder holder NN 10_1101-2020_03_27_012757 358 7 for for IN 10_1101-2020_03_27_012757 358 8 this this DT 10_1101-2020_03_27_012757 358 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 358 10 version version NN 10_1101-2020_03_27_012757 358 11 posted post VBD 10_1101-2020_03_27_012757 358 12 January January NNP 10_1101-2020_03_27_012757 358 13 9 9 CD 10_1101-2020_03_27_012757 358 14 , , , 10_1101-2020_03_27_012757 358 15 2021 2021 CD 10_1101-2020_03_27_012757 358 16 . . . 10_1101-2020_03_27_012757 358 17 ; ; : 10_1101-2020_03_27_012757 358 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 358 19 : : : 10_1101-2020_03_27_012757 358 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 358 21 preprint preprint NN 10_1101-2020_03_27_012757 358 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 358 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 358 24 27 27 CD 10_1101-2020_03_27_012757 358 25 profiles profile NNS 10_1101-2020_03_27_012757 358 26 spanning span VBG 10_1101-2020_03_27_012757 358 27 4 4 CD 10_1101-2020_03_27_012757 358 28 purified purify VBN 10_1101-2020_03_27_012757 358 29 cell cell NN 10_1101-2020_03_27_012757 358 30 types type NNS 10_1101-2020_03_27_012757 358 31 ( ( -LRB- 10_1101-2020_03_27_012757 358 32 B b NN 10_1101-2020_03_27_012757 358 33 cells cell NNS 10_1101-2020_03_27_012757 358 34 , , , 10_1101-2020_03_27_012757 358 35 endothelial endothelial JJ 10_1101-2020_03_27_012757 358 36 cells cell NNS 10_1101-2020_03_27_012757 358 37 , , , 10_1101-2020_03_27_012757 358 38 monocyte monocyte NN 10_1101-2020_03_27_012757 358 39 / / SYM 10_1101-2020_03_27_012757 358 40 macrophage macrophage NN 10_1101-2020_03_27_012757 358 41 , , , 10_1101-2020_03_27_012757 358 42 705 705 CD 10_1101-2020_03_27_012757 358 43 fibroblast fibroblast NN 10_1101-2020_03_27_012757 358 44 ) ) -RRB- 10_1101-2020_03_27_012757 358 45 from from IN 10_1101-2020_03_27_012757 358 46 https://github.com/pcahan1/CellNet https://github.com/pcahan1/CellNet NNP 10_1101-2020_03_27_012757 358 47 . . . 10_1101-2020_03_27_012757 359 1 706 706 CD 10_1101-2020_03_27_012757 359 2 707 707 CD 10_1101-2020_03_27_012757 359 3 Training Training NNP 10_1101-2020_03_27_012757 359 4 Subtype Subtype NNP 10_1101-2020_03_27_012757 359 5 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 359 6 708 708 CD 10_1101-2020_03_27_012757 359 7 We -PRON- PRP 10_1101-2020_03_27_012757 359 8 found find VBD 10_1101-2020_03_27_012757 359 9 11 11 CD 10_1101-2020_03_27_012757 359 10 cancer cancer NN 10_1101-2020_03_27_012757 359 11 types type NNS 10_1101-2020_03_27_012757 359 12 ( ( -LRB- 10_1101-2020_03_27_012757 359 13 BRCA BRCA NNP 10_1101-2020_03_27_012757 359 14 , , , 10_1101-2020_03_27_012757 359 15 COAD COAD NNP 10_1101-2020_03_27_012757 359 16 , , , 10_1101-2020_03_27_012757 359 17 ESCA ESCA NNP 10_1101-2020_03_27_012757 359 18 , , , 10_1101-2020_03_27_012757 359 19 HNSC HNSC NNP 10_1101-2020_03_27_012757 359 20 , , , 10_1101-2020_03_27_012757 359 21 KIRC KIRC NNP 10_1101-2020_03_27_012757 359 22 , , , 10_1101-2020_03_27_012757 359 23 LGG LGG NNP 10_1101-2020_03_27_012757 359 24 , , , 10_1101-2020_03_27_012757 359 25 PAAD PAAD NNP 10_1101-2020_03_27_012757 359 26 , , , 10_1101-2020_03_27_012757 359 27 UCEC UCEC NNP 10_1101-2020_03_27_012757 359 28 , , , 10_1101-2020_03_27_012757 359 29 709 709 CD 10_1101-2020_03_27_012757 359 30 STAD stad NN 10_1101-2020_03_27_012757 359 31 , , , 10_1101-2020_03_27_012757 359 32 LUAD luad RB 10_1101-2020_03_27_012757 359 33 , , , 10_1101-2020_03_27_012757 359 34 LUSC LUSC NNP 10_1101-2020_03_27_012757 359 35 ) ) -RRB- 10_1101-2020_03_27_012757 359 36 which which WDT 10_1101-2020_03_27_012757 359 37 have have VBP 10_1101-2020_03_27_012757 359 38 meaningful meaningful JJ 10_1101-2020_03_27_012757 359 39 subtypes subtype NNS 10_1101-2020_03_27_012757 359 40 based base VBN 10_1101-2020_03_27_012757 359 41 on on IN 10_1101-2020_03_27_012757 359 42 either either DT 10_1101-2020_03_27_012757 359 43 histology histology NN 10_1101-2020_03_27_012757 359 44 or or CC 10_1101-2020_03_27_012757 359 45 molecular molecular NNP 10_1101-2020_03_27_012757 359 46 710 710 CD 10_1101-2020_03_27_012757 359 47 profile profile NN 10_1101-2020_03_27_012757 359 48 and and CC 10_1101-2020_03_27_012757 359 49 have have VB 10_1101-2020_03_27_012757 359 50 sufficient sufficient JJ 10_1101-2020_03_27_012757 359 51 samples sample NNS 10_1101-2020_03_27_012757 359 52 to to TO 10_1101-2020_03_27_012757 359 53 train train VB 10_1101-2020_03_27_012757 359 54 a a DT 10_1101-2020_03_27_012757 359 55 subtype subtype NN 10_1101-2020_03_27_012757 359 56 classifier classifier NN 10_1101-2020_03_27_012757 359 57 with with IN 10_1101-2020_03_27_012757 359 58 high high JJ 10_1101-2020_03_27_012757 359 59 AUPR AUPR NNP 10_1101-2020_03_27_012757 359 60 . . . 10_1101-2020_03_27_012757 360 1 We -PRON- PRP 10_1101-2020_03_27_012757 360 2 also also RB 10_1101-2020_03_27_012757 360 3 711 711 CD 10_1101-2020_03_27_012757 360 4 included include VBD 10_1101-2020_03_27_012757 360 5 normal normal JJ 10_1101-2020_03_27_012757 360 6 tissues tissue NNS 10_1101-2020_03_27_012757 360 7 samples sample NNS 10_1101-2020_03_27_012757 360 8 from from IN 10_1101-2020_03_27_012757 360 9 BRCA BRCA NNP 10_1101-2020_03_27_012757 360 10 , , , 10_1101-2020_03_27_012757 360 11 COAD COAD NNP 10_1101-2020_03_27_012757 360 12 , , , 10_1101-2020_03_27_012757 360 13 HNSC HNSC NNP 10_1101-2020_03_27_012757 360 14 , , , 10_1101-2020_03_27_012757 360 15 KIRC KIRC NNP 10_1101-2020_03_27_012757 360 16 , , , 10_1101-2020_03_27_012757 360 17 UCEC UCEC NNP 10_1101-2020_03_27_012757 360 18 to to TO 10_1101-2020_03_27_012757 360 19 create create VB 10_1101-2020_03_27_012757 360 20 a a DT 10_1101-2020_03_27_012757 360 21 normal normal JJ 10_1101-2020_03_27_012757 360 22 712 712 CD 10_1101-2020_03_27_012757 360 23 tissue tissue NN 10_1101-2020_03_27_012757 360 24 category category NN 10_1101-2020_03_27_012757 360 25 in in IN 10_1101-2020_03_27_012757 360 26 the the DT 10_1101-2020_03_27_012757 360 27 construction construction NN 10_1101-2020_03_27_012757 360 28 of of IN 10_1101-2020_03_27_012757 360 29 their -PRON- PRP$ 10_1101-2020_03_27_012757 360 30 subtype subtype NN 10_1101-2020_03_27_012757 360 31 classifiers classifier NNS 10_1101-2020_03_27_012757 360 32 . . . 10_1101-2020_03_27_012757 361 1 Training training NN 10_1101-2020_03_27_012757 361 2 samples sample NNS 10_1101-2020_03_27_012757 361 3 were be VBD 10_1101-2020_03_27_012757 361 4 either either CC 10_1101-2020_03_27_012757 361 5 713 713 CD 10_1101-2020_03_27_012757 361 6 labelled label VBN 10_1101-2020_03_27_012757 361 7 as as IN 10_1101-2020_03_27_012757 361 8 a a DT 10_1101-2020_03_27_012757 361 9 cancer cancer NN 10_1101-2020_03_27_012757 361 10 subtype subtype NN 10_1101-2020_03_27_012757 361 11 for for IN 10_1101-2020_03_27_012757 361 12 the the DT 10_1101-2020_03_27_012757 361 13 cancer cancer NN 10_1101-2020_03_27_012757 361 14 of of IN 10_1101-2020_03_27_012757 361 15 interest interest NN 10_1101-2020_03_27_012757 361 16 or or CC 10_1101-2020_03_27_012757 361 17 as as IN 10_1101-2020_03_27_012757 361 18 “ " `` 10_1101-2020_03_27_012757 361 19 Unknown unknown JJ 10_1101-2020_03_27_012757 361 20 ” " '' 10_1101-2020_03_27_012757 361 21 if if IN 10_1101-2020_03_27_012757 361 22 they -PRON- PRP 10_1101-2020_03_27_012757 361 23 belong belong VBP 10_1101-2020_03_27_012757 361 24 to to IN 10_1101-2020_03_27_012757 361 25 other other JJ 10_1101-2020_03_27_012757 361 26 714 714 CD 10_1101-2020_03_27_012757 361 27 cancer cancer NN 10_1101-2020_03_27_012757 361 28 types type NNS 10_1101-2020_03_27_012757 361 29 . . . 10_1101-2020_03_27_012757 362 1 Similar similar JJ 10_1101-2020_03_27_012757 362 2 to to IN 10_1101-2020_03_27_012757 362 3 general general JJ 10_1101-2020_03_27_012757 362 4 classifier classifier NN 10_1101-2020_03_27_012757 362 5 training training NN 10_1101-2020_03_27_012757 362 6 , , , 10_1101-2020_03_27_012757 362 7 CCN CCN NNP 10_1101-2020_03_27_012757 362 8 performed perform VBD 10_1101-2020_03_27_012757 362 9 gene gene NN 10_1101-2020_03_27_012757 362 10 pair pair NN 10_1101-2020_03_27_012757 362 11 transformation transformation NN 10_1101-2020_03_27_012757 362 12 and and CC 10_1101-2020_03_27_012757 362 13 715 715 CD 10_1101-2020_03_27_012757 362 14 selected select VBD 10_1101-2020_03_27_012757 362 15 the the DT 10_1101-2020_03_27_012757 362 16 most most RBS 10_1101-2020_03_27_012757 362 17 discriminate discriminate NN 10_1101-2020_03_27_012757 362 18 gene gene NN 10_1101-2020_03_27_012757 362 19 pairs pair NNS 10_1101-2020_03_27_012757 362 20 for for IN 10_1101-2020_03_27_012757 362 21 each each DT 10_1101-2020_03_27_012757 362 22 cancer cancer NN 10_1101-2020_03_27_012757 362 23 subtype subtype NN 10_1101-2020_03_27_012757 362 24 . . . 10_1101-2020_03_27_012757 363 1 In in IN 10_1101-2020_03_27_012757 363 2 addition addition NN 10_1101-2020_03_27_012757 363 3 to to IN 10_1101-2020_03_27_012757 363 4 the the DT 10_1101-2020_03_27_012757 363 5 gene gene NN 10_1101-2020_03_27_012757 363 6 pairs pairs NNP 10_1101-2020_03_27_012757 363 7 716 716 CD 10_1101-2020_03_27_012757 363 8 selected select VBN 10_1101-2020_03_27_012757 363 9 to to TO 10_1101-2020_03_27_012757 363 10 discriminate discriminate VB 10_1101-2020_03_27_012757 363 11 cancer cancer NN 10_1101-2020_03_27_012757 363 12 subtypes subtype NNS 10_1101-2020_03_27_012757 363 13 , , , 10_1101-2020_03_27_012757 363 14 CCN CCN NNP 10_1101-2020_03_27_012757 363 15 also also RB 10_1101-2020_03_27_012757 363 16 performed perform VBD 10_1101-2020_03_27_012757 363 17 general general JJ 10_1101-2020_03_27_012757 363 18 classification classification NN 10_1101-2020_03_27_012757 363 19 of of IN 10_1101-2020_03_27_012757 363 20 all all DT 10_1101-2020_03_27_012757 363 21 717 717 CD 10_1101-2020_03_27_012757 363 22 training training NN 10_1101-2020_03_27_012757 363 23 data datum NNS 10_1101-2020_03_27_012757 363 24 and and CC 10_1101-2020_03_27_012757 363 25 appended append VBD 10_1101-2020_03_27_012757 363 26 the the DT 10_1101-2020_03_27_012757 363 27 classification classification NN 10_1101-2020_03_27_012757 363 28 profiles profile NNS 10_1101-2020_03_27_012757 363 29 of of IN 10_1101-2020_03_27_012757 363 30 training train VBG 10_1101-2020_03_27_012757 363 31 data datum NNS 10_1101-2020_03_27_012757 363 32 with with IN 10_1101-2020_03_27_012757 363 33 gene gene NN 10_1101-2020_03_27_012757 363 34 pair pair NN 10_1101-2020_03_27_012757 363 35 binary binary NNP 10_1101-2020_03_27_012757 363 36 718 718 CD 10_1101-2020_03_27_012757 363 37 matrix matrix NN 10_1101-2020_03_27_012757 363 38 as as IN 10_1101-2020_03_27_012757 363 39 additional additional JJ 10_1101-2020_03_27_012757 363 40 features feature NNS 10_1101-2020_03_27_012757 363 41 . . . 10_1101-2020_03_27_012757 364 1 The the DT 10_1101-2020_03_27_012757 364 2 reason reason NN 10_1101-2020_03_27_012757 364 3 behind behind IN 10_1101-2020_03_27_012757 364 4 using use VBG 10_1101-2020_03_27_012757 364 5 general general JJ 10_1101-2020_03_27_012757 364 6 classification classification NN 10_1101-2020_03_27_012757 364 7 profile profile NN 10_1101-2020_03_27_012757 364 8 as as IN 10_1101-2020_03_27_012757 364 9 additional additional JJ 10_1101-2020_03_27_012757 364 10 719 719 CD 10_1101-2020_03_27_012757 364 11 features feature NNS 10_1101-2020_03_27_012757 364 12 is be VBZ 10_1101-2020_03_27_012757 364 13 that that IN 10_1101-2020_03_27_012757 364 14 many many JJ 10_1101-2020_03_27_012757 364 15 general general JJ 10_1101-2020_03_27_012757 364 16 cancer cancer NN 10_1101-2020_03_27_012757 364 17 types type NNS 10_1101-2020_03_27_012757 364 18 may may MD 10_1101-2020_03_27_012757 364 19 share share VB 10_1101-2020_03_27_012757 364 20 similar similar JJ 10_1101-2020_03_27_012757 364 21 subtypes subtype NNS 10_1101-2020_03_27_012757 364 22 , , , 10_1101-2020_03_27_012757 364 23 and and CC 10_1101-2020_03_27_012757 364 24 general general JJ 10_1101-2020_03_27_012757 364 25 720 720 CD 10_1101-2020_03_27_012757 364 26 classification classification NN 10_1101-2020_03_27_012757 364 27 profile profile NN 10_1101-2020_03_27_012757 364 28 could could MD 10_1101-2020_03_27_012757 364 29 be be VB 10_1101-2020_03_27_012757 364 30 important important JJ 10_1101-2020_03_27_012757 364 31 features feature NNS 10_1101-2020_03_27_012757 364 32 to to TO 10_1101-2020_03_27_012757 364 33 discriminate discriminate VB 10_1101-2020_03_27_012757 364 34 the the DT 10_1101-2020_03_27_012757 364 35 general general JJ 10_1101-2020_03_27_012757 364 36 cancer cancer NN 10_1101-2020_03_27_012757 364 37 type type NN 10_1101-2020_03_27_012757 364 38 of of IN 10_1101-2020_03_27_012757 364 39 721 721 CD 10_1101-2020_03_27_012757 364 40 interest interest NN 10_1101-2020_03_27_012757 364 41 from from IN 10_1101-2020_03_27_012757 364 42 other other JJ 10_1101-2020_03_27_012757 364 43 cancer cancer NN 10_1101-2020_03_27_012757 364 44 types type NNS 10_1101-2020_03_27_012757 364 45 before before IN 10_1101-2020_03_27_012757 364 46 performing perform VBG 10_1101-2020_03_27_012757 364 47 finer fine JJR 10_1101-2020_03_27_012757 364 48 subtype subtype NN 10_1101-2020_03_27_012757 364 49 classification classification NN 10_1101-2020_03_27_012757 364 50 . . . 10_1101-2020_03_27_012757 365 1 The the DT 10_1101-2020_03_27_012757 365 2 specific specific JJ 10_1101-2020_03_27_012757 365 3 722 722 CD 10_1101-2020_03_27_012757 365 4 parameters parameter NNS 10_1101-2020_03_27_012757 365 5 used use VBN 10_1101-2020_03_27_012757 365 6 to to TO 10_1101-2020_03_27_012757 365 7 train train VB 10_1101-2020_03_27_012757 365 8 individual individual JJ 10_1101-2020_03_27_012757 365 9 subtype subtype NN 10_1101-2020_03_27_012757 365 10 classifiers classifier NNS 10_1101-2020_03_27_012757 365 11 using use VBG 10_1101-2020_03_27_012757 365 12 “ " `` 10_1101-2020_03_27_012757 365 13 subClass_train subClass_train , 10_1101-2020_03_27_012757 365 14 ” " '' 10_1101-2020_03_27_012757 365 15 function function NN 10_1101-2020_03_27_012757 365 16 of of IN 10_1101-2020_03_27_012757 365 17 723 723 CD 10_1101-2020_03_27_012757 365 18 CancerCellNet cancercellnet JJ 10_1101-2020_03_27_012757 365 19 package package NN 10_1101-2020_03_27_012757 365 20 can can MD 10_1101-2020_03_27_012757 365 21 be be VB 10_1101-2020_03_27_012757 365 22 found find VBN 10_1101-2020_03_27_012757 365 23 in in IN 10_1101-2020_03_27_012757 365 24 Supp Supp NNP 10_1101-2020_03_27_012757 365 25 Tab Tab NNP 10_1101-2020_03_27_012757 365 26 9 9 CD 10_1101-2020_03_27_012757 365 27 and and CC 10_1101-2020_03_27_012757 365 28 the the DT 10_1101-2020_03_27_012757 365 29 gene gene NN 10_1101-2020_03_27_012757 365 30 pairs pair NNS 10_1101-2020_03_27_012757 365 31 are be VBP 10_1101-2020_03_27_012757 365 32 in in IN 10_1101-2020_03_27_012757 365 33 Supp Supp NNP 10_1101-2020_03_27_012757 365 34 Tab Tab NNP 10_1101-2020_03_27_012757 365 35 10 10 CD 10_1101-2020_03_27_012757 365 36 . . . 10_1101-2020_03_27_012757 366 1 724 724 CD 10_1101-2020_03_27_012757 366 2 725 725 CD 10_1101-2020_03_27_012757 366 3 Validating Validating NNP 10_1101-2020_03_27_012757 366 4 Subtype Subtype NNP 10_1101-2020_03_27_012757 366 5 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 366 6 726 726 CD 10_1101-2020_03_27_012757 366 7 Similar Similar NNP 10_1101-2020_03_27_012757 366 8 to to IN 10_1101-2020_03_27_012757 366 9 validating validate VBG 10_1101-2020_03_27_012757 366 10 general general JJ 10_1101-2020_03_27_012757 366 11 class class NN 10_1101-2020_03_27_012757 366 12 classifier classifier NN 10_1101-2020_03_27_012757 366 13 , , , 10_1101-2020_03_27_012757 366 14 we -PRON- PRP 10_1101-2020_03_27_012757 366 15 randomly randomly RB 10_1101-2020_03_27_012757 366 16 sampled sample VBD 10_1101-2020_03_27_012757 366 17 2/3 2/3 CD 10_1101-2020_03_27_012757 366 18 of of IN 10_1101-2020_03_27_012757 366 19 all all DT 10_1101-2020_03_27_012757 366 20 samples sample NNS 10_1101-2020_03_27_012757 366 21 in in IN 10_1101-2020_03_27_012757 366 22 727 727 CD 10_1101-2020_03_27_012757 366 23 each each DT 10_1101-2020_03_27_012757 366 24 cancer cancer NN 10_1101-2020_03_27_012757 366 25 subtype subtype NN 10_1101-2020_03_27_012757 366 26 as as IN 10_1101-2020_03_27_012757 366 27 training training NN 10_1101-2020_03_27_012757 366 28 data datum NNS 10_1101-2020_03_27_012757 366 29 and and CC 10_1101-2020_03_27_012757 366 30 sampled sample VBD 10_1101-2020_03_27_012757 366 31 an an DT 10_1101-2020_03_27_012757 366 32 equal equal JJ 10_1101-2020_03_27_012757 366 33 amount amount NN 10_1101-2020_03_27_012757 366 34 across across IN 10_1101-2020_03_27_012757 366 35 subtypes subtype NNS 10_1101-2020_03_27_012757 366 36 in in IN 10_1101-2020_03_27_012757 366 37 the the DT 10_1101-2020_03_27_012757 366 38 1/3 1/3 CD 10_1101-2020_03_27_012757 366 39 728 728 CD 10_1101-2020_03_27_012757 366 40 held hold VBN 10_1101-2020_03_27_012757 366 41 - - HYPH 10_1101-2020_03_27_012757 366 42 out out RP 10_1101-2020_03_27_012757 366 43 data datum NNS 10_1101-2020_03_27_012757 366 44 for for IN 10_1101-2020_03_27_012757 366 45 assessing assess VBG 10_1101-2020_03_27_012757 366 46 subtype subtype NN 10_1101-2020_03_27_012757 366 47 classifiers classifier NNS 10_1101-2020_03_27_012757 366 48 . . . 10_1101-2020_03_27_012757 367 1 We -PRON- PRP 10_1101-2020_03_27_012757 367 2 repeated repeat VBD 10_1101-2020_03_27_012757 367 3 the the DT 10_1101-2020_03_27_012757 367 4 process process NN 10_1101-2020_03_27_012757 367 5 20 20 CD 10_1101-2020_03_27_012757 367 6 times time NNS 10_1101-2020_03_27_012757 367 7 for for IN 10_1101-2020_03_27_012757 367 8 more more JJR 10_1101-2020_03_27_012757 367 9 729 729 CD 10_1101-2020_03_27_012757 367 10 comprehensive comprehensive JJ 10_1101-2020_03_27_012757 367 11 assessment assessment NN 10_1101-2020_03_27_012757 367 12 of of IN 10_1101-2020_03_27_012757 367 13 subtype subtype NN 10_1101-2020_03_27_012757 367 14 classifiers classifier NNS 10_1101-2020_03_27_012757 367 15 . . . 10_1101-2020_03_27_012757 368 1 730 730 CD 10_1101-2020_03_27_012757 368 2 .CC .CC : 10_1101-2020_03_27_012757 368 3 - - HYPH 10_1101-2020_03_27_012757 368 4 BY by IN 10_1101-2020_03_27_012757 368 5 - - HYPH 10_1101-2020_03_27_012757 368 6 NC NC NNP 10_1101-2020_03_27_012757 368 7 - - HYPH 10_1101-2020_03_27_012757 368 8 ND ND NNP 10_1101-2020_03_27_012757 368 9 4.0 4.0 CD 10_1101-2020_03_27_012757 368 10 International International NNP 10_1101-2020_03_27_012757 368 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 368 12 under under IN 10_1101-2020_03_27_012757 368 13 a a DT 10_1101-2020_03_27_012757 368 14 ( ( -LRB- 10_1101-2020_03_27_012757 368 15 which which WDT 10_1101-2020_03_27_012757 368 16 was be VBD 10_1101-2020_03_27_012757 368 17 not not RB 10_1101-2020_03_27_012757 368 18 certified certify VBN 10_1101-2020_03_27_012757 368 19 by by IN 10_1101-2020_03_27_012757 368 20 peer peer NN 10_1101-2020_03_27_012757 368 21 review review NN 10_1101-2020_03_27_012757 368 22 ) ) -RRB- 10_1101-2020_03_27_012757 368 23 is be VBZ 10_1101-2020_03_27_012757 368 24 the the DT 10_1101-2020_03_27_012757 368 25 author author NN 10_1101-2020_03_27_012757 368 26 / / SYM 10_1101-2020_03_27_012757 368 27 funder funder NN 10_1101-2020_03_27_012757 368 28 , , , 10_1101-2020_03_27_012757 368 29 who who WP 10_1101-2020_03_27_012757 368 30 has have VBZ 10_1101-2020_03_27_012757 368 31 granted grant VBN 10_1101-2020_03_27_012757 368 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 368 33 a a DT 10_1101-2020_03_27_012757 368 34 license license NN 10_1101-2020_03_27_012757 368 35 to to TO 10_1101-2020_03_27_012757 368 36 display display VB 10_1101-2020_03_27_012757 368 37 the the DT 10_1101-2020_03_27_012757 368 38 preprint preprint NN 10_1101-2020_03_27_012757 368 39 in in IN 10_1101-2020_03_27_012757 368 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 368 41 . . . 10_1101-2020_03_27_012757 369 1 It -PRON- PRP 10_1101-2020_03_27_012757 369 2 is be VBZ 10_1101-2020_03_27_012757 369 3 made make VBN 10_1101-2020_03_27_012757 369 4 The the DT 10_1101-2020_03_27_012757 369 5 copyright copyright NN 10_1101-2020_03_27_012757 369 6 holder holder NN 10_1101-2020_03_27_012757 369 7 for for IN 10_1101-2020_03_27_012757 369 8 this this DT 10_1101-2020_03_27_012757 369 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 369 10 version version NN 10_1101-2020_03_27_012757 369 11 posted post VBD 10_1101-2020_03_27_012757 369 12 January January NNP 10_1101-2020_03_27_012757 369 13 9 9 CD 10_1101-2020_03_27_012757 369 14 , , , 10_1101-2020_03_27_012757 369 15 2021 2021 CD 10_1101-2020_03_27_012757 369 16 . . . 10_1101-2020_03_27_012757 369 17 ; ; : 10_1101-2020_03_27_012757 369 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 369 19 : : : 10_1101-2020_03_27_012757 369 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 369 21 preprint preprint NN 10_1101-2020_03_27_012757 369 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 369 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 369 24 28 28 CD 10_1101-2020_03_27_012757 369 25 Classifying classify VBG 10_1101-2020_03_27_012757 369 26 Query Query NNP 10_1101-2020_03_27_012757 369 27 Data Data NNP 10_1101-2020_03_27_012757 369 28 into into IN 10_1101-2020_03_27_012757 369 29 Subtypes subtype NNS 10_1101-2020_03_27_012757 369 30 731 731 CD 10_1101-2020_03_27_012757 369 31 We -PRON- PRP 10_1101-2020_03_27_012757 369 32 assigned assign VBD 10_1101-2020_03_27_012757 369 33 subtype subtype NN 10_1101-2020_03_27_012757 369 34 to to IN 10_1101-2020_03_27_012757 369 35 query query NN 10_1101-2020_03_27_012757 369 36 sample sample VB 10_1101-2020_03_27_012757 369 37 if if IN 10_1101-2020_03_27_012757 369 38 the the DT 10_1101-2020_03_27_012757 369 39 query query NN 10_1101-2020_03_27_012757 369 40 sample sample NN 10_1101-2020_03_27_012757 369 41 has have VBZ 10_1101-2020_03_27_012757 369 42 CCN CCN NNP 10_1101-2020_03_27_012757 369 43 score score VB 10_1101-2020_03_27_012757 369 44 higher high JJR 10_1101-2020_03_27_012757 369 45 than than IN 10_1101-2020_03_27_012757 369 46 732 732 CD 10_1101-2020_03_27_012757 369 47 the the DT 10_1101-2020_03_27_012757 369 48 decision decision NN 10_1101-2020_03_27_012757 369 49 threshold threshold NN 10_1101-2020_03_27_012757 369 50 . . . 10_1101-2020_03_27_012757 370 1 The the DT 10_1101-2020_03_27_012757 370 2 table table NN 10_1101-2020_03_27_012757 370 3 of of IN 10_1101-2020_03_27_012757 370 4 decision decision NN 10_1101-2020_03_27_012757 370 5 threshold threshold NN 10_1101-2020_03_27_012757 370 6 for for IN 10_1101-2020_03_27_012757 370 7 subtype subtype NN 10_1101-2020_03_27_012757 370 8 classifiers classifier NNS 10_1101-2020_03_27_012757 370 9 are be VBP 10_1101-2020_03_27_012757 370 10 in in IN 10_1101-2020_03_27_012757 370 11 Supp Supp NNP 10_1101-2020_03_27_012757 370 12 Tab Tab NNP 10_1101-2020_03_27_012757 370 13 733 733 CD 10_1101-2020_03_27_012757 370 14 11 11 CD 10_1101-2020_03_27_012757 370 15 . . . 10_1101-2020_03_27_012757 371 1 If if IN 10_1101-2020_03_27_012757 371 2 no no DT 10_1101-2020_03_27_012757 371 3 CCN CCN NNP 10_1101-2020_03_27_012757 371 4 scores score NNS 10_1101-2020_03_27_012757 371 5 exceed exceed VBP 10_1101-2020_03_27_012757 371 6 the the DT 10_1101-2020_03_27_012757 371 7 decision decision NN 10_1101-2020_03_27_012757 371 8 threshold threshold NN 10_1101-2020_03_27_012757 371 9 in in IN 10_1101-2020_03_27_012757 371 10 any any DT 10_1101-2020_03_27_012757 371 11 subtype subtype NN 10_1101-2020_03_27_012757 371 12 or or CC 10_1101-2020_03_27_012757 371 13 if if IN 10_1101-2020_03_27_012757 371 14 the the DT 10_1101-2020_03_27_012757 371 15 highest high JJS 10_1101-2020_03_27_012757 371 16 CCN CCN NNP 10_1101-2020_03_27_012757 371 17 score score NN 10_1101-2020_03_27_012757 371 18 734 734 CD 10_1101-2020_03_27_012757 371 19 is be VBZ 10_1101-2020_03_27_012757 371 20 in in IN 10_1101-2020_03_27_012757 371 21 ‘ ' `` 10_1101-2020_03_27_012757 371 22 Unknown unknown JJ 10_1101-2020_03_27_012757 371 23 ’ ' '' 10_1101-2020_03_27_012757 371 24 category category NN 10_1101-2020_03_27_012757 371 25 , , , 10_1101-2020_03_27_012757 371 26 then then RB 10_1101-2020_03_27_012757 371 27 we -PRON- PRP 10_1101-2020_03_27_012757 371 28 assigned assign VBD 10_1101-2020_03_27_012757 371 29 that that DT 10_1101-2020_03_27_012757 371 30 sample sample NN 10_1101-2020_03_27_012757 371 31 as as IN 10_1101-2020_03_27_012757 371 32 ‘ ' `` 10_1101-2020_03_27_012757 371 33 Unknown unknown JJ 10_1101-2020_03_27_012757 371 34 ’ ' '' 10_1101-2020_03_27_012757 371 35 . . . 10_1101-2020_03_27_012757 372 1 Analysis analysis NN 10_1101-2020_03_27_012757 372 2 was be VBD 10_1101-2020_03_27_012757 372 3 performed perform VBN 10_1101-2020_03_27_012757 372 4 735 735 CD 10_1101-2020_03_27_012757 372 5 in in IN 10_1101-2020_03_27_012757 372 6 R r NN 10_1101-2020_03_27_012757 372 7 and and CC 10_1101-2020_03_27_012757 372 8 visualizations visualization NNS 10_1101-2020_03_27_012757 372 9 were be VBD 10_1101-2020_03_27_012757 372 10 generated generate VBN 10_1101-2020_03_27_012757 372 11 with with IN 10_1101-2020_03_27_012757 372 12 the the DT 10_1101-2020_03_27_012757 372 13 ComplexHeatmap ComplexHeatmap NNP 10_1101-2020_03_27_012757 372 14 package94 package94 NN 10_1101-2020_03_27_012757 372 15 . . . 10_1101-2020_03_27_012757 373 1 736 736 CD 10_1101-2020_03_27_012757 373 2 737 737 CD 10_1101-2020_03_27_012757 373 3 Cells cell NNS 10_1101-2020_03_27_012757 373 4 culture culture NN 10_1101-2020_03_27_012757 373 5 , , , 10_1101-2020_03_27_012757 373 6 Immunohistochemistry Immunohistochemistry NNP 10_1101-2020_03_27_012757 373 7 and and CC 10_1101-2020_03_27_012757 373 8 histomorphometry histomorphometry NN 10_1101-2020_03_27_012757 373 9 738 738 CD 10_1101-2020_03_27_012757 373 10 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 373 11 ( ( -LRB- 10_1101-2020_03_27_012757 373 12 ATCC ATCC NNP 10_1101-2020_03_27_012757 373 13 ® ® NNPS 10_1101-2020_03_27_012757 373 14 HTB-76 htb-76 CD 10_1101-2020_03_27_012757 373 15 ™ ™ CD 10_1101-2020_03_27_012757 373 16 ) ) -RRB- 10_1101-2020_03_27_012757 373 17 , , , 10_1101-2020_03_27_012757 373 18 SK SK NNP 10_1101-2020_03_27_012757 373 19 - - HYPH 10_1101-2020_03_27_012757 373 20 OV-3(ATCC OV-3(ATCC NNP 10_1101-2020_03_27_012757 373 21 ® ® NNPS 10_1101-2020_03_27_012757 373 22 HTB-77 HTB-77 NNP 10_1101-2020_03_27_012757 373 23 ™ ™ CD 10_1101-2020_03_27_012757 373 24 ) ) -RRB- 10_1101-2020_03_27_012757 373 25 , , , 10_1101-2020_03_27_012757 373 26 RT4 RT4 NNP 10_1101-2020_03_27_012757 373 27 ( ( -LRB- 10_1101-2020_03_27_012757 373 28 ATCC ATCC NNP 10_1101-2020_03_27_012757 373 29 ® ® NNPS 10_1101-2020_03_27_012757 373 30 HTB-2 HTB-2 NNP 10_1101-2020_03_27_012757 373 31 ™ ™ CD 10_1101-2020_03_27_012757 373 32 ) ) -RRB- 10_1101-2020_03_27_012757 373 33 , , , 10_1101-2020_03_27_012757 373 34 and and CC 10_1101-2020_03_27_012757 373 35 739 739 CD 10_1101-2020_03_27_012757 373 36 NCCIT(ATCC NCCIT(ATCC NNP 10_1101-2020_03_27_012757 373 37 ® ® NNP 10_1101-2020_03_27_012757 373 38 CRL-2073 CRL-2073 NNP 10_1101-2020_03_27_012757 373 39 ™ ™ CD 10_1101-2020_03_27_012757 373 40 ) ) -RRB- 10_1101-2020_03_27_012757 373 41 cell cell NN 10_1101-2020_03_27_012757 373 42 lines line NNS 10_1101-2020_03_27_012757 373 43 were be VBD 10_1101-2020_03_27_012757 373 44 purchased purchase VBN 10_1101-2020_03_27_012757 373 45 from from IN 10_1101-2020_03_27_012757 373 46 ATCC ATCC NNP 10_1101-2020_03_27_012757 373 47 . . . 10_1101-2020_03_27_012757 374 1 HEC-59 HEC-59 NNP 10_1101-2020_03_27_012757 374 2 ( ( -LRB- 10_1101-2020_03_27_012757 374 3 C0026001 C0026001 NNP 10_1101-2020_03_27_012757 374 4 ) ) -RRB- 10_1101-2020_03_27_012757 374 5 and and CC 10_1101-2020_03_27_012757 374 6 740 740 CD 10_1101-2020_03_27_012757 374 7 A2780 a2780 NN 10_1101-2020_03_27_012757 374 8 ( ( -LRB- 10_1101-2020_03_27_012757 374 9 93112519 93112519 CD 10_1101-2020_03_27_012757 374 10 - - SYM 10_1101-2020_03_27_012757 374 11 1VL 1vl CD 10_1101-2020_03_27_012757 374 12 ) ) -RRB- 10_1101-2020_03_27_012757 374 13 were be VBD 10_1101-2020_03_27_012757 374 14 obtained obtain VBN 10_1101-2020_03_27_012757 374 15 from from IN 10_1101-2020_03_27_012757 374 16 Addexbio Addexbio NNP 10_1101-2020_03_27_012757 374 17 Technologies Technologies NNPS 10_1101-2020_03_27_012757 374 18 and and CC 10_1101-2020_03_27_012757 374 19 Sigma Sigma NNP 10_1101-2020_03_27_012757 374 20 - - HYPH 10_1101-2020_03_27_012757 374 21 Aldrich Aldrich NNP 10_1101-2020_03_27_012757 374 22 . . . 10_1101-2020_03_27_012757 375 1 Vcap Vcap NNP 10_1101-2020_03_27_012757 375 2 741 741 CD 10_1101-2020_03_27_012757 375 3 and and CC 10_1101-2020_03_27_012757 375 4 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 375 5 . . . 10_1101-2020_03_27_012757 376 1 SK SK NNP 10_1101-2020_03_27_012757 376 2 - - HYPH 10_1101-2020_03_27_012757 376 3 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 376 4 , , , 10_1101-2020_03_27_012757 376 5 Vcap Vcap NNP 10_1101-2020_03_27_012757 376 6 , , , 10_1101-2020_03_27_012757 376 7 and and CC 10_1101-2020_03_27_012757 376 8 RT4 RT4 NNP 10_1101-2020_03_27_012757 376 9 were be VBD 10_1101-2020_03_27_012757 376 10 cultured culture VBN 10_1101-2020_03_27_012757 376 11 in in IN 10_1101-2020_03_27_012757 376 12 Dulbecco Dulbecco NNP 10_1101-2020_03_27_012757 376 13 's 's POS 10_1101-2020_03_27_012757 376 14 Modified Modified NNP 10_1101-2020_03_27_012757 376 15 Eagle Eagle NNP 10_1101-2020_03_27_012757 376 16 Medium Medium NNP 10_1101-2020_03_27_012757 376 17 742 742 CD 10_1101-2020_03_27_012757 376 18 ( ( -LRB- 10_1101-2020_03_27_012757 376 19 DMEM DMEM NNS 10_1101-2020_03_27_012757 376 20 , , , 10_1101-2020_03_27_012757 376 21 high high JJ 10_1101-2020_03_27_012757 376 22 glucose glucose NN 10_1101-2020_03_27_012757 376 23 , , , 10_1101-2020_03_27_012757 376 24 11960069 11960069 CD 10_1101-2020_03_27_012757 376 25 , , , 10_1101-2020_03_27_012757 376 26 Gibco Gibco NNP 10_1101-2020_03_27_012757 376 27 ) ) -RRB- 10_1101-2020_03_27_012757 376 28 with with IN 10_1101-2020_03_27_012757 376 29 1 1 CD 10_1101-2020_03_27_012757 376 30 % % NN 10_1101-2020_03_27_012757 376 31 Penicillin Penicillin NNP 10_1101-2020_03_27_012757 376 32 - - HYPH 10_1101-2020_03_27_012757 376 33 Streptomycin Streptomycin NNP 10_1101-2020_03_27_012757 376 34 - - HYPH 10_1101-2020_03_27_012757 376 35 Glutamine Glutamine NNP 10_1101-2020_03_27_012757 376 36 ( ( -LRB- 10_1101-2020_03_27_012757 376 37 743 743 CD 10_1101-2020_03_27_012757 376 38 10378016 10378016 CD 10_1101-2020_03_27_012757 376 39 , , , 10_1101-2020_03_27_012757 376 40 Life Life NNP 10_1101-2020_03_27_012757 376 41 Technologies Technologies NNP 10_1101-2020_03_27_012757 376 42 ) ) -RRB- 10_1101-2020_03_27_012757 376 43 ; ; : 10_1101-2020_03_27_012757 376 44 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 376 45 , , , 10_1101-2020_03_27_012757 376 46 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 376 47 , , , 10_1101-2020_03_27_012757 376 48 NCCIT NCCIT NNP 10_1101-2020_03_27_012757 376 49 , , , 10_1101-2020_03_27_012757 376 50 and and CC 10_1101-2020_03_27_012757 376 51 A2780 A2780 NNP 10_1101-2020_03_27_012757 376 52 were be VBD 10_1101-2020_03_27_012757 376 53 cultured culture VBN 10_1101-2020_03_27_012757 376 54 using use VBG 10_1101-2020_03_27_012757 376 55 RPMI-744 RPMI-744 NNP 10_1101-2020_03_27_012757 376 56 1640 1640 CD 10_1101-2020_03_27_012757 376 57 medium medium NN 10_1101-2020_03_27_012757 376 58 ( ( -LRB- 10_1101-2020_03_27_012757 376 59 11875093 11875093 CD 10_1101-2020_03_27_012757 376 60 , , , 10_1101-2020_03_27_012757 376 61 Gibco Gibco NNP 10_1101-2020_03_27_012757 376 62 ) ) -RRB- 10_1101-2020_03_27_012757 376 63 while while IN 10_1101-2020_03_27_012757 376 64 HEC-59 HEC-59 NNP 10_1101-2020_03_27_012757 376 65 was be VBD 10_1101-2020_03_27_012757 376 66 in in IN 10_1101-2020_03_27_012757 376 67 Iscove Iscove NNP 10_1101-2020_03_27_012757 376 68 's 's POS 10_1101-2020_03_27_012757 376 69 Modified Modified NNP 10_1101-2020_03_27_012757 376 70 Dulbecco Dulbecco NNP 10_1101-2020_03_27_012757 376 71 's 's POS 10_1101-2020_03_27_012757 376 72 Medium Medium NNP 10_1101-2020_03_27_012757 376 73 745 745 CD 10_1101-2020_03_27_012757 376 74 ( ( -LRB- 10_1101-2020_03_27_012757 376 75 IMDM IMDM NNP 10_1101-2020_03_27_012757 376 76 , , , 10_1101-2020_03_27_012757 376 77 12440053 12440053 CD 10_1101-2020_03_27_012757 376 78 , , , 10_1101-2020_03_27_012757 376 79 Gibco Gibco NNP 10_1101-2020_03_27_012757 376 80 ) ) -RRB- 10_1101-2020_03_27_012757 376 81 . . . 10_1101-2020_03_27_012757 377 1 Both both DT 10_1101-2020_03_27_012757 377 2 media medium NNS 10_1101-2020_03_27_012757 377 3 were be VBD 10_1101-2020_03_27_012757 377 4 supplemented supplement VBN 10_1101-2020_03_27_012757 377 5 with with IN 10_1101-2020_03_27_012757 377 6 1 1 CD 10_1101-2020_03_27_012757 377 7 % % NN 10_1101-2020_03_27_012757 377 8 Penicillin Penicillin NNP 10_1101-2020_03_27_012757 377 9 - - HYPH 10_1101-2020_03_27_012757 377 10 Streptomycin Streptomycin NNP 10_1101-2020_03_27_012757 377 11 746 746 CD 10_1101-2020_03_27_012757 377 12 ( ( -LRB- 10_1101-2020_03_27_012757 377 13 15140122 15140122 CD 10_1101-2020_03_27_012757 377 14 , , , 10_1101-2020_03_27_012757 377 15 Gibco Gibco NNP 10_1101-2020_03_27_012757 377 16 ) ) -RRB- 10_1101-2020_03_27_012757 377 17 . . . 10_1101-2020_03_27_012757 378 1 All all DT 10_1101-2020_03_27_012757 378 2 medium medium NN 10_1101-2020_03_27_012757 378 3 included include VBD 10_1101-2020_03_27_012757 378 4 10 10 CD 10_1101-2020_03_27_012757 378 5 % % NN 10_1101-2020_03_27_012757 378 6 Fetal Fetal NNP 10_1101-2020_03_27_012757 378 7 Bovine Bovine NNP 10_1101-2020_03_27_012757 378 8 Serum Serum NNP 10_1101-2020_03_27_012757 378 9 ( ( -LRB- 10_1101-2020_03_27_012757 378 10 FBS FBS NNP 10_1101-2020_03_27_012757 378 11 ) ) -RRB- 10_1101-2020_03_27_012757 378 12 . . . 10_1101-2020_03_27_012757 379 1 747 747 CD 10_1101-2020_03_27_012757 379 2 Cells cell NNS 10_1101-2020_03_27_012757 379 3 cultured culture VBD 10_1101-2020_03_27_012757 379 4 in in IN 10_1101-2020_03_27_012757 379 5 48-well 48-well CD 10_1101-2020_03_27_012757 379 6 plate plate NN 10_1101-2020_03_27_012757 379 7 were be VBD 10_1101-2020_03_27_012757 379 8 washed wash VBN 10_1101-2020_03_27_012757 379 9 twice twice RB 10_1101-2020_03_27_012757 379 10 with with IN 10_1101-2020_03_27_012757 379 11 PBS PBS NNP 10_1101-2020_03_27_012757 379 12 and and CC 10_1101-2020_03_27_012757 379 13 fixed fix VBN 10_1101-2020_03_27_012757 379 14 in in IN 10_1101-2020_03_27_012757 379 15 10 10 CD 10_1101-2020_03_27_012757 379 16 % % NN 10_1101-2020_03_27_012757 379 17 buffered buffer VBN 10_1101-2020_03_27_012757 379 18 748 748 CD 10_1101-2020_03_27_012757 379 19 formalin formalin NN 10_1101-2020_03_27_012757 379 20 for for IN 10_1101-2020_03_27_012757 379 21 24 24 CD 10_1101-2020_03_27_012757 379 22     _SP 10_1101-2020_03_27_012757 379 23 hrs hrs VBP 10_1101-2020_03_27_012757 379 24 at at IN 10_1101-2020_03_27_012757 379 25 4 4 CD 10_1101-2020_03_27_012757 379 26 ° ° NNS 10_1101-2020_03_27_012757 379 27 C C NNP 10_1101-2020_03_27_012757 379 28 . . . 10_1101-2020_03_27_012757 380 1 Immunostaining Immunostaining NNP 10_1101-2020_03_27_012757 380 2 was be VBD 10_1101-2020_03_27_012757 380 3 performed perform VBN 10_1101-2020_03_27_012757 380 4 using use VBG 10_1101-2020_03_27_012757 380 5 a a DT 10_1101-2020_03_27_012757 380 6 standard standard JJ 10_1101-2020_03_27_012757 380 7 protocol protocol NN 10_1101-2020_03_27_012757 380 8 . . . 10_1101-2020_03_27_012757 381 1 Cells cell NNS 10_1101-2020_03_27_012757 381 2 749 749 CD 10_1101-2020_03_27_012757 381 3 were be VBD 10_1101-2020_03_27_012757 381 4 incubated incubate VBN 10_1101-2020_03_27_012757 381 5 with with IN 10_1101-2020_03_27_012757 381 6 primary primary JJ 10_1101-2020_03_27_012757 381 7 antibodies antibody NNS 10_1101-2020_03_27_012757 381 8 to to IN 10_1101-2020_03_27_012757 381 9 goat goat NNP 10_1101-2020_03_27_012757 381 10 HOXB6 HOXB6 . 10_1101-2020_03_27_012757 381 11 ( ( -LRB- 10_1101-2020_03_27_012757 381 12 10 10 CD 10_1101-2020_03_27_012757 381 13 µg µg CD 10_1101-2020_03_27_012757 381 14 / / SYM 10_1101-2020_03_27_012757 381 15 mL mL NNP 10_1101-2020_03_27_012757 381 16 , , , 10_1101-2020_03_27_012757 381 17 PA5 PA5 NNP 10_1101-2020_03_27_012757 381 18 - - HYPH 10_1101-2020_03_27_012757 381 19 37867 37867 CD 10_1101-2020_03_27_012757 381 20 , , , 10_1101-2020_03_27_012757 381 21 Invitrogen Invitrogen NNP 10_1101-2020_03_27_012757 381 22 ) ) -RRB- 10_1101-2020_03_27_012757 381 23 , , , 10_1101-2020_03_27_012757 381 24 750 750 CD 10_1101-2020_03_27_012757 381 25 mouse mouse NN 10_1101-2020_03_27_012757 381 26 WT1(10 WT1(10 NNP 10_1101-2020_03_27_012757 381 27 µg µg NNP 10_1101-2020_03_27_012757 381 28 / / SYM 10_1101-2020_03_27_012757 381 29 mL mL NNP 10_1101-2020_03_27_012757 381 30 , , , 10_1101-2020_03_27_012757 381 31 MA1 MA1 NNP 10_1101-2020_03_27_012757 381 32 - - HYPH 10_1101-2020_03_27_012757 381 33 46028 46028 CD 10_1101-2020_03_27_012757 381 34 , , , 10_1101-2020_03_27_012757 381 35 Invitrogen Invitrogen NNP 10_1101-2020_03_27_012757 381 36 ) ) -RRB- 10_1101-2020_03_27_012757 381 37 , , , 10_1101-2020_03_27_012757 381 38 rabbit rabbit NN 10_1101-2020_03_27_012757 381 39 PPARG PPARG NNP 10_1101-2020_03_27_012757 381 40 ( ( -LRB- 10_1101-2020_03_27_012757 381 41 1:50 1:50 CD 10_1101-2020_03_27_012757 381 42 , , , 10_1101-2020_03_27_012757 381 43 ABN1445 ABN1445 NNP 10_1101-2020_03_27_012757 381 44 , , , 10_1101-2020_03_27_012757 381 45 Millipore Millipore NNP 10_1101-2020_03_27_012757 381 46 ) ) -RRB- 10_1101-2020_03_27_012757 381 47 , , , 10_1101-2020_03_27_012757 381 48 751 751 CD 10_1101-2020_03_27_012757 381 49 mouse mouse NN 10_1101-2020_03_27_012757 381 50 FOLH1(10 folh1(10 NN 10_1101-2020_03_27_012757 381 51 µg µg . 10_1101-2020_03_27_012757 381 52 / / SYM 10_1101-2020_03_27_012757 381 53 mL mL NNP 10_1101-2020_03_27_012757 381 54 , , , 10_1101-2020_03_27_012757 381 55 UM570025 UM570025 NNP 10_1101-2020_03_27_012757 381 56 , , , 10_1101-2020_03_27_012757 381 57 Origene Origene NNP 10_1101-2020_03_27_012757 381 58 ) ) -RRB- 10_1101-2020_03_27_012757 381 59 , , , 10_1101-2020_03_27_012757 381 60 and and CC 10_1101-2020_03_27_012757 381 61 rabbit rabbit NN 10_1101-2020_03_27_012757 381 62 LIN28A lin28a CD 10_1101-2020_03_27_012757 381 63 ( ( -LRB- 10_1101-2020_03_27_012757 381 64 1:50 1:50 CD 10_1101-2020_03_27_012757 381 65 , , , 10_1101-2020_03_27_012757 381 66 # # $ 10_1101-2020_03_27_012757 381 67 3978 3978 CD 10_1101-2020_03_27_012757 381 68 , , , 10_1101-2020_03_27_012757 381 69 Cell Cell NNP 10_1101-2020_03_27_012757 381 70 Signaling Signaling NNP 10_1101-2020_03_27_012757 381 71 ) ) -RRB- 10_1101-2020_03_27_012757 381 72 752 752 CD 10_1101-2020_03_27_012757 381 73 in in IN 10_1101-2020_03_27_012757 381 74 Antibody Antibody NNP 10_1101-2020_03_27_012757 381 75 Diluent Diluent NNP 10_1101-2020_03_27_012757 381 76 ( ( -LRB- 10_1101-2020_03_27_012757 381 77 S080981 S080981 NNP 10_1101-2020_03_27_012757 381 78 - - HYPH 10_1101-2020_03_27_012757 381 79 2 2 CD 10_1101-2020_03_27_012757 381 80 , , , 10_1101-2020_03_27_012757 381 81 DAKO DAKO NNP 10_1101-2020_03_27_012757 381 82 ) ) -RRB- 10_1101-2020_03_27_012757 381 83 , , , 10_1101-2020_03_27_012757 381 84 at at IN 10_1101-2020_03_27_012757 381 85 4 4 CD 10_1101-2020_03_27_012757 381 86     _SP 10_1101-2020_03_27_012757 381 87 ° ° , 10_1101-2020_03_27_012757 381 88 C C NNP 10_1101-2020_03_27_012757 381 89 overnight overnight RB 10_1101-2020_03_27_012757 381 90 followed follow VBD 10_1101-2020_03_27_012757 381 91 with with IN 10_1101-2020_03_27_012757 381 92 three three CD 10_1101-2020_03_27_012757 381 93 5 5 CD 10_1101-2020_03_27_012757 381 94 min min NN 10_1101-2020_03_27_012757 381 95 washes wash NNS 10_1101-2020_03_27_012757 381 96 in in IN 10_1101-2020_03_27_012757 381 97 753 753 CD 10_1101-2020_03_27_012757 381 98 TBST TBST NNP 10_1101-2020_03_27_012757 381 99 . . . 10_1101-2020_03_27_012757 382 1 The the DT 10_1101-2020_03_27_012757 382 2 slides slide NNS 10_1101-2020_03_27_012757 382 3 were be VBD 10_1101-2020_03_27_012757 382 4 then then RB 10_1101-2020_03_27_012757 382 5 incubated incubate VBN 10_1101-2020_03_27_012757 382 6 with with IN 10_1101-2020_03_27_012757 382 7 secondary secondary JJ 10_1101-2020_03_27_012757 382 8 antibodies antibody NNS 10_1101-2020_03_27_012757 382 9 conjugated conjugate VBN 10_1101-2020_03_27_012757 382 10 with with IN 10_1101-2020_03_27_012757 382 11 fluorescence fluorescence NN 10_1101-2020_03_27_012757 382 12 754 754 CD 10_1101-2020_03_27_012757 382 13 at at IN 10_1101-2020_03_27_012757 382 14 room room NN 10_1101-2020_03_27_012757 382 15 temperature temperature NN 10_1101-2020_03_27_012757 382 16 for for IN 10_1101-2020_03_27_012757 382 17 1 1 CD 10_1101-2020_03_27_012757 382 18     _SP 10_1101-2020_03_27_012757 382 19 h h NN 10_1101-2020_03_27_012757 382 20 while while IN 10_1101-2020_03_27_012757 382 21 avoiding avoid VBG 10_1101-2020_03_27_012757 382 22 light light NN 10_1101-2020_03_27_012757 382 23 followed follow VBN 10_1101-2020_03_27_012757 382 24 with with IN 10_1101-2020_03_27_012757 382 25 three three CD 10_1101-2020_03_27_012757 382 26 5 5 CD 10_1101-2020_03_27_012757 382 27 min min NN 10_1101-2020_03_27_012757 382 28 washes wash NNS 10_1101-2020_03_27_012757 382 29 in in IN 10_1101-2020_03_27_012757 382 30 TBST TBST NNP 10_1101-2020_03_27_012757 382 31 and and CC 10_1101-2020_03_27_012757 382 32 755 755 CD 10_1101-2020_03_27_012757 382 33 .CC .CC : 10_1101-2020_03_27_012757 382 34 - - HYPH 10_1101-2020_03_27_012757 382 35 BY by IN 10_1101-2020_03_27_012757 382 36 - - HYPH 10_1101-2020_03_27_012757 382 37 NC NC NNP 10_1101-2020_03_27_012757 382 38 - - HYPH 10_1101-2020_03_27_012757 382 39 ND ND NNP 10_1101-2020_03_27_012757 382 40 4.0 4.0 CD 10_1101-2020_03_27_012757 382 41 International International NNP 10_1101-2020_03_27_012757 382 42 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 382 43 under under IN 10_1101-2020_03_27_012757 382 44 a a DT 10_1101-2020_03_27_012757 382 45 ( ( -LRB- 10_1101-2020_03_27_012757 382 46 which which WDT 10_1101-2020_03_27_012757 382 47 was be VBD 10_1101-2020_03_27_012757 382 48 not not RB 10_1101-2020_03_27_012757 382 49 certified certify VBN 10_1101-2020_03_27_012757 382 50 by by IN 10_1101-2020_03_27_012757 382 51 peer peer NN 10_1101-2020_03_27_012757 382 52 review review NN 10_1101-2020_03_27_012757 382 53 ) ) -RRB- 10_1101-2020_03_27_012757 382 54 is be VBZ 10_1101-2020_03_27_012757 382 55 the the DT 10_1101-2020_03_27_012757 382 56 author author NN 10_1101-2020_03_27_012757 382 57 / / SYM 10_1101-2020_03_27_012757 382 58 funder funder NN 10_1101-2020_03_27_012757 382 59 , , , 10_1101-2020_03_27_012757 382 60 who who WP 10_1101-2020_03_27_012757 382 61 has have VBZ 10_1101-2020_03_27_012757 382 62 granted grant VBN 10_1101-2020_03_27_012757 382 63 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 382 64 a a DT 10_1101-2020_03_27_012757 382 65 license license NN 10_1101-2020_03_27_012757 382 66 to to TO 10_1101-2020_03_27_012757 382 67 display display VB 10_1101-2020_03_27_012757 382 68 the the DT 10_1101-2020_03_27_012757 382 69 preprint preprint NN 10_1101-2020_03_27_012757 382 70 in in IN 10_1101-2020_03_27_012757 382 71 perpetuity perpetuity NN 10_1101-2020_03_27_012757 382 72 . . . 10_1101-2020_03_27_012757 383 1 It -PRON- PRP 10_1101-2020_03_27_012757 383 2 is be VBZ 10_1101-2020_03_27_012757 383 3 made make VBN 10_1101-2020_03_27_012757 383 4 The the DT 10_1101-2020_03_27_012757 383 5 copyright copyright NN 10_1101-2020_03_27_012757 383 6 holder holder NN 10_1101-2020_03_27_012757 383 7 for for IN 10_1101-2020_03_27_012757 383 8 this this DT 10_1101-2020_03_27_012757 383 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 383 10 version version NN 10_1101-2020_03_27_012757 383 11 posted post VBD 10_1101-2020_03_27_012757 383 12 January January NNP 10_1101-2020_03_27_012757 383 13 9 9 CD 10_1101-2020_03_27_012757 383 14 , , , 10_1101-2020_03_27_012757 383 15 2021 2021 CD 10_1101-2020_03_27_012757 383 16 . . . 10_1101-2020_03_27_012757 383 17 ; ; : 10_1101-2020_03_27_012757 383 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 383 19 : : : 10_1101-2020_03_27_012757 383 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 383 21 preprint preprint NN 10_1101-2020_03_27_012757 383 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 383 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 383 24 29 29 CD 10_1101-2020_03_27_012757 383 25 nuclear nuclear NN 10_1101-2020_03_27_012757 383 26 stained stain VBN 10_1101-2020_03_27_012757 383 27 with with IN 10_1101-2020_03_27_012757 383 28 mounting mount VBG 10_1101-2020_03_27_012757 383 29 medium medium NN 10_1101-2020_03_27_012757 383 30 containing contain VBG 10_1101-2020_03_27_012757 383 31 DAPI dapi NN 10_1101-2020_03_27_012757 383 32 . . . 10_1101-2020_03_27_012757 384 1 Images image NNS 10_1101-2020_03_27_012757 384 2 were be VBD 10_1101-2020_03_27_012757 384 3 captured capture VBN 10_1101-2020_03_27_012757 384 4 by by IN 10_1101-2020_03_27_012757 384 5 Nikon Nikon NNP 10_1101-2020_03_27_012757 384 6 756 756 CD 10_1101-2020_03_27_012757 384 7 EcLipse EcLipse NNP 10_1101-2020_03_27_012757 384 8 Ti Ti NNP 10_1101-2020_03_27_012757 384 9 - - HYPH 10_1101-2020_03_27_012757 384 10 S S NNP 10_1101-2020_03_27_012757 384 11 , , , 10_1101-2020_03_27_012757 384 12 DS DS NNP 10_1101-2020_03_27_012757 384 13 - - HYPH 10_1101-2020_03_27_012757 384 14 U3 U3 NNP 10_1101-2020_03_27_012757 384 15 and and CC 10_1101-2020_03_27_012757 384 16 DS DS NNP 10_1101-2020_03_27_012757 384 17 - - HYPH 10_1101-2020_03_27_012757 384 18 Qi2 Qi2 NNP 10_1101-2020_03_27_012757 384 19 . . . 10_1101-2020_03_27_012757 385 1 757 757 CD 10_1101-2020_03_27_012757 385 2 Histomorphometry Histomorphometry NNP 10_1101-2020_03_27_012757 385 3 was be VBD 10_1101-2020_03_27_012757 385 4 performed perform VBN 10_1101-2020_03_27_012757 385 5 using use VBG 10_1101-2020_03_27_012757 385 6 ImageJ ImageJ NNP 10_1101-2020_03_27_012757 385 7 ( ( -LRB- 10_1101-2020_03_27_012757 385 8 Version Version NNP 10_1101-2020_03_27_012757 385 9 2.0.0-rc-69/1.52i 2.0.0-rc-69/1.52i NNP 10_1101-2020_03_27_012757 385 10 ) ) -RRB- 10_1101-2020_03_27_012757 385 11 . . . 10_1101-2020_03_27_012757 386 1 % % NN 10_1101-2020_03_27_012757 386 2 758 758 CD 10_1101-2020_03_27_012757 386 3 N.positive n.positive JJ 10_1101-2020_03_27_012757 386 4 cells cell NNS 10_1101-2020_03_27_012757 386 5 was be VBD 10_1101-2020_03_27_012757 386 6 calculated calculate VBN 10_1101-2020_03_27_012757 386 7 by by IN 10_1101-2020_03_27_012757 386 8 the the DT 10_1101-2020_03_27_012757 386 9 percentage percentage NN 10_1101-2020_03_27_012757 386 10 of of IN 10_1101-2020_03_27_012757 386 11 the the DT 10_1101-2020_03_27_012757 386 12 number number NN 10_1101-2020_03_27_012757 386 13 of of IN 10_1101-2020_03_27_012757 386 14 positive positive JJ 10_1101-2020_03_27_012757 386 15 stained stain VBN 10_1101-2020_03_27_012757 386 16 cells cell NNS 10_1101-2020_03_27_012757 386 17 divided divide VBD 10_1101-2020_03_27_012757 386 18 759 759 CD 10_1101-2020_03_27_012757 386 19 by by IN 10_1101-2020_03_27_012757 386 20 the the DT 10_1101-2020_03_27_012757 386 21 number number NN 10_1101-2020_03_27_012757 386 22 of of IN 10_1101-2020_03_27_012757 386 23 DAPI dapi NN 10_1101-2020_03_27_012757 386 24 - - HYPH 10_1101-2020_03_27_012757 386 25 positive positive JJ 10_1101-2020_03_27_012757 386 26 nucleus nucleus NN 10_1101-2020_03_27_012757 386 27 within within IN 10_1101-2020_03_27_012757 386 28 three three CD 10_1101-2020_03_27_012757 386 29 of of IN 10_1101-2020_03_27_012757 386 30 randomly randomly RB 10_1101-2020_03_27_012757 386 31 chosen choose VBN 10_1101-2020_03_27_012757 386 32 areas area NNS 10_1101-2020_03_27_012757 386 33 . . . 10_1101-2020_03_27_012757 387 1 The the DT 10_1101-2020_03_27_012757 387 2 data datum NNS 10_1101-2020_03_27_012757 387 3 were be VBD 10_1101-2020_03_27_012757 387 4 760 760 CD 10_1101-2020_03_27_012757 387 5 expressed express VBN 10_1101-2020_03_27_012757 387 6 as as IN 10_1101-2020_03_27_012757 387 7 means mean VBZ 10_1101-2020_03_27_012757 387 8 ± ± NNP 10_1101-2020_03_27_012757 387 9 SD sd NN 10_1101-2020_03_27_012757 387 10 . . . 10_1101-2020_03_27_012757 388 1 761 761 CD 10_1101-2020_03_27_012757 388 2 762 762 CD 10_1101-2020_03_27_012757 388 3 Tumor Tumor NNP 10_1101-2020_03_27_012757 388 4 Purity Purity NNP 10_1101-2020_03_27_012757 388 5 Analysis Analysis NNP 10_1101-2020_03_27_012757 388 6 763 763 CD 10_1101-2020_03_27_012757 388 7 We -PRON- PRP 10_1101-2020_03_27_012757 388 8 used use VBD 10_1101-2020_03_27_012757 388 9 the the DT 10_1101-2020_03_27_012757 388 10 R r NN 10_1101-2020_03_27_012757 388 11 package package NN 10_1101-2020_03_27_012757 388 12 ESTIMATE95 ESTIMATE95 NNS 10_1101-2020_03_27_012757 388 13 to to TO 10_1101-2020_03_27_012757 388 14 calculate calculate VB 10_1101-2020_03_27_012757 388 15 the the DT 10_1101-2020_03_27_012757 388 16 ESTIMATE estimate NN 10_1101-2020_03_27_012757 388 17 scores score NNS 10_1101-2020_03_27_012757 388 18 from from IN 10_1101-2020_03_27_012757 388 19 TCGA TCGA NNP 10_1101-2020_03_27_012757 388 20 764 764 CD 10_1101-2020_03_27_012757 388 21 tumor tumor NN 10_1101-2020_03_27_012757 388 22 expression expression NN 10_1101-2020_03_27_012757 388 23 profiles profile NNS 10_1101-2020_03_27_012757 388 24 that that WDT 10_1101-2020_03_27_012757 388 25 we -PRON- PRP 10_1101-2020_03_27_012757 388 26 used use VBD 10_1101-2020_03_27_012757 388 27 as as IN 10_1101-2020_03_27_012757 388 28 training training NN 10_1101-2020_03_27_012757 388 29 data datum NNS 10_1101-2020_03_27_012757 388 30 for for IN 10_1101-2020_03_27_012757 388 31 CCN CCN NNP 10_1101-2020_03_27_012757 388 32 classifier classifier NN 10_1101-2020_03_27_012757 388 33 . . . 10_1101-2020_03_27_012757 389 1 To to TO 10_1101-2020_03_27_012757 389 2 calculate calculate VB 10_1101-2020_03_27_012757 389 3 tumor tumor NN 10_1101-2020_03_27_012757 389 4 765 765 CD 10_1101-2020_03_27_012757 389 5 purity purity NN 10_1101-2020_03_27_012757 389 6 we -PRON- PRP 10_1101-2020_03_27_012757 389 7 used use VBD 10_1101-2020_03_27_012757 389 8 the the DT 10_1101-2020_03_27_012757 389 9 equation equation NN 10_1101-2020_03_27_012757 389 10 described describe VBN 10_1101-2020_03_27_012757 389 11 in in IN 10_1101-2020_03_27_012757 389 12 YoshiHara YoshiHara NNP 10_1101-2020_03_27_012757 389 13 et et FW 10_1101-2020_03_27_012757 389 14 al al NNP 10_1101-2020_03_27_012757 389 15 . . NNP 10_1101-2020_03_27_012757 389 16 , , , 10_1101-2020_03_27_012757 389 17 201395 201395 CD 10_1101-2020_03_27_012757 389 18 : : : 10_1101-2020_03_27_012757 389 19 766 766 CD 10_1101-2020_03_27_012757 389 20 Tumour Tumour NNP 10_1101-2020_03_27_012757 389 21 purity purity NN 10_1101-2020_03_27_012757 389 22 = = SYM 10_1101-2020_03_27_012757 389 23 cos cos NNP 10_1101-2020_03_27_012757 389 24 ( ( -LRB- 10_1101-2020_03_27_012757 389 25 0.6049872018 0.6049872018 CD 10_1101-2020_03_27_012757 389 26 + + SYM 10_1101-2020_03_27_012757 389 27 0.0001467884 0.0001467884 CD 10_1101-2020_03_27_012757 389 28 × × NN 10_1101-2020_03_27_012757 389 29 ESTIMATE estimate NN 10_1101-2020_03_27_012757 389 30 score score NN 10_1101-2020_03_27_012757 389 31 ) ) -RRB- 10_1101-2020_03_27_012757 389 32 767 767 CD 10_1101-2020_03_27_012757 389 33 768 768 CD 10_1101-2020_03_27_012757 389 34 Extracting Extracting NNP 10_1101-2020_03_27_012757 389 35 Citation citation NN 10_1101-2020_03_27_012757 389 36 Counts count VBZ 10_1101-2020_03_27_012757 389 37 769 769 CD 10_1101-2020_03_27_012757 389 38 We -PRON- PRP 10_1101-2020_03_27_012757 389 39 used use VBD 10_1101-2020_03_27_012757 389 40 the the DT 10_1101-2020_03_27_012757 389 41 R r NN 10_1101-2020_03_27_012757 389 42 package package NN 10_1101-2020_03_27_012757 389 43 RISmed96 RISmed96 NNP 10_1101-2020_03_27_012757 389 44 to to TO 10_1101-2020_03_27_012757 389 45 extract extract VB 10_1101-2020_03_27_012757 389 46 the the DT 10_1101-2020_03_27_012757 389 47 number number NN 10_1101-2020_03_27_012757 389 48 of of IN 10_1101-2020_03_27_012757 389 49 citations citation NNS 10_1101-2020_03_27_012757 389 50 for for IN 10_1101-2020_03_27_012757 389 51 each each DT 10_1101-2020_03_27_012757 389 52 cell cell NN 10_1101-2020_03_27_012757 389 53 line line NN 10_1101-2020_03_27_012757 389 54 770 770 CD 10_1101-2020_03_27_012757 389 55 through through IN 10_1101-2020_03_27_012757 389 56 query query NN 10_1101-2020_03_27_012757 389 57 search search NN 10_1101-2020_03_27_012757 389 58 of of IN 10_1101-2020_03_27_012757 389 59 “ " `` 10_1101-2020_03_27_012757 389 60 cell cell NN 10_1101-2020_03_27_012757 389 61 line line NN 10_1101-2020_03_27_012757 389 62 name[Text name[text IN 10_1101-2020_03_27_012757 389 63 Word Word NNP 10_1101-2020_03_27_012757 389 64 ] ] -RRB- 10_1101-2020_03_27_012757 389 65 AND and CC 10_1101-2020_03_27_012757 389 66 cancer[Text cancer[Text NNP 10_1101-2020_03_27_012757 389 67 Word Word NNP 10_1101-2020_03_27_012757 389 68 ] ] -RRB- 10_1101-2020_03_27_012757 389 69 ” " '' 10_1101-2020_03_27_012757 389 70 on on IN 10_1101-2020_03_27_012757 389 71 PubMed PubMed NNP 10_1101-2020_03_27_012757 389 72 . . . 10_1101-2020_03_27_012757 390 1 The the DT 10_1101-2020_03_27_012757 390 2 771 771 CD 10_1101-2020_03_27_012757 390 3 citation citation NN 10_1101-2020_03_27_012757 390 4 counts count NNS 10_1101-2020_03_27_012757 390 5 were be VBD 10_1101-2020_03_27_012757 390 6 normalized normalize VBN 10_1101-2020_03_27_012757 390 7 by by IN 10_1101-2020_03_27_012757 390 8 dividing divide VBG 10_1101-2020_03_27_012757 390 9 the the DT 10_1101-2020_03_27_012757 390 10 citation citation NN 10_1101-2020_03_27_012757 390 11 counts count NNS 10_1101-2020_03_27_012757 390 12 with with IN 10_1101-2020_03_27_012757 390 13 the the DT 10_1101-2020_03_27_012757 390 14 number number NN 10_1101-2020_03_27_012757 390 15 of of IN 10_1101-2020_03_27_012757 390 16 years year NNS 10_1101-2020_03_27_012757 390 17 since since IN 10_1101-2020_03_27_012757 390 18 772 772 CD 10_1101-2020_03_27_012757 390 19 first first JJ 10_1101-2020_03_27_012757 390 20 documented document VBN 10_1101-2020_03_27_012757 390 21 . . . 10_1101-2020_03_27_012757 391 1 773 773 CD 10_1101-2020_03_27_012757 391 2 𝑁𝑜𝑟𝑚𝑎𝑙𝑖𝑧𝑒𝑑 𝑁𝑜𝑟𝑚𝑎𝑙𝑖𝑧𝑒𝑑 NNS 10_1101-2020_03_27_012757 391 3 𝑐𝑖𝑡𝑎𝑡𝑖𝑜𝑛 𝑐𝑖𝑡𝑎𝑡𝑖𝑜𝑛 VBP 10_1101-2020_03_27_012757 391 4 𝑐𝑜𝑢𝑛𝑡𝑠 𝑐𝑜𝑢𝑛𝑡𝑠 NNP 10_1101-2020_03_27_012757 391 5 = = SYM 10_1101-2020_03_27_012757 391 6 𝑐𝑖𝑡𝑎𝑡𝑖𝑜𝑛 𝑐𝑖𝑡𝑎𝑡𝑖𝑜𝑛 VB 10_1101-2020_03_27_012757 391 7 𝑐𝑜𝑢𝑛𝑡𝑠 𝑐𝑜𝑢𝑛𝑡𝑠 NNP 10_1101-2020_03_27_012757 391 8 # # NNP 10_1101-2020_03_27_012757 391 9 𝑦𝑒𝑎𝑟𝑠 𝑦𝑒𝑎𝑟𝑠 NNP 10_1101-2020_03_27_012757 391 10 𝑠𝑖𝑛𝑐𝑒 𝑠𝑖𝑛𝑐𝑒 NNP 10_1101-2020_03_27_012757 391 11 𝑓𝑖𝑟𝑠𝑡 𝑓𝑖𝑟𝑠𝑡 NNP 10_1101-2020_03_27_012757 391 12 𝑑𝑜𝑐𝑢𝑚𝑒𝑛𝑡𝑒𝑑 𝑑𝑜𝑐𝑢𝑚𝑒𝑛𝑡𝑒𝑑 NNP 10_1101-2020_03_27_012757 391 13 774 774 CD 10_1101-2020_03_27_012757 391 14 775 775 CD 10_1101-2020_03_27_012757 391 15 GRN GRN NNP 10_1101-2020_03_27_012757 391 16 construction construction NN 10_1101-2020_03_27_012757 391 17 and and CC 10_1101-2020_03_27_012757 391 18 GRN GRN NNP 10_1101-2020_03_27_012757 391 19 Status Status NNP 10_1101-2020_03_27_012757 391 20 776 776 CD 10_1101-2020_03_27_012757 391 21 GRN GRN NNP 10_1101-2020_03_27_012757 391 22 construction construction NN 10_1101-2020_03_27_012757 391 23 was be VBD 10_1101-2020_03_27_012757 391 24 extended extend VBN 10_1101-2020_03_27_012757 391 25 from from IN 10_1101-2020_03_27_012757 391 26 our -PRON- PRP$ 10_1101-2020_03_27_012757 391 27 previous previous JJ 10_1101-2020_03_27_012757 391 28 method21 method21 CD 10_1101-2020_03_27_012757 391 29 . . . 10_1101-2020_03_27_012757 392 1 80 80 CD 10_1101-2020_03_27_012757 392 2 samples sample NNS 10_1101-2020_03_27_012757 392 3 per per IN 10_1101-2020_03_27_012757 392 4 cancer cancer NN 10_1101-2020_03_27_012757 392 5 777 777 CD 10_1101-2020_03_27_012757 392 6 type type NN 10_1101-2020_03_27_012757 392 7 were be VBD 10_1101-2020_03_27_012757 392 8 randomly randomly RB 10_1101-2020_03_27_012757 392 9 sampled sample VBN 10_1101-2020_03_27_012757 392 10 and and CC 10_1101-2020_03_27_012757 392 11 normalized normalize VBN 10_1101-2020_03_27_012757 392 12 through through IN 10_1101-2020_03_27_012757 392 13 down down RB 10_1101-2020_03_27_012757 392 14 sampling sampling NN 10_1101-2020_03_27_012757 392 15 as as IN 10_1101-2020_03_27_012757 392 16 training training NN 10_1101-2020_03_27_012757 392 17 data datum NNS 10_1101-2020_03_27_012757 392 18 for for IN 10_1101-2020_03_27_012757 392 19 the the DT 10_1101-2020_03_27_012757 392 20 778 778 CD 10_1101-2020_03_27_012757 392 21 CLR CLR NNP 10_1101-2020_03_27_012757 392 22 GRN GRN NNP 10_1101-2020_03_27_012757 392 23 construction construction NN 10_1101-2020_03_27_012757 392 24 algorithm algorithm NN 10_1101-2020_03_27_012757 392 25 . . . 10_1101-2020_03_27_012757 393 1 Cancer cancer NN 10_1101-2020_03_27_012757 393 2 type type NN 10_1101-2020_03_27_012757 393 3 specific specific JJ 10_1101-2020_03_27_012757 393 4 GRNs grn NNS 10_1101-2020_03_27_012757 393 5 were be VBD 10_1101-2020_03_27_012757 393 6 identified identify VBN 10_1101-2020_03_27_012757 393 7 by by IN 10_1101-2020_03_27_012757 393 8 determining determine VBG 10_1101-2020_03_27_012757 393 9 the the DT 10_1101-2020_03_27_012757 393 10 779 779 CD 10_1101-2020_03_27_012757 393 11 .CC .CC : 10_1101-2020_03_27_012757 393 12 - - HYPH 10_1101-2020_03_27_012757 393 13 BY by IN 10_1101-2020_03_27_012757 393 14 - - HYPH 10_1101-2020_03_27_012757 393 15 NC NC NNP 10_1101-2020_03_27_012757 393 16 - - HYPH 10_1101-2020_03_27_012757 393 17 ND ND NNP 10_1101-2020_03_27_012757 393 18 4.0 4.0 CD 10_1101-2020_03_27_012757 393 19 International International NNP 10_1101-2020_03_27_012757 393 20 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 393 21 under under IN 10_1101-2020_03_27_012757 393 22 a a DT 10_1101-2020_03_27_012757 393 23 ( ( -LRB- 10_1101-2020_03_27_012757 393 24 which which WDT 10_1101-2020_03_27_012757 393 25 was be VBD 10_1101-2020_03_27_012757 393 26 not not RB 10_1101-2020_03_27_012757 393 27 certified certify VBN 10_1101-2020_03_27_012757 393 28 by by IN 10_1101-2020_03_27_012757 393 29 peer peer NN 10_1101-2020_03_27_012757 393 30 review review NN 10_1101-2020_03_27_012757 393 31 ) ) -RRB- 10_1101-2020_03_27_012757 393 32 is be VBZ 10_1101-2020_03_27_012757 393 33 the the DT 10_1101-2020_03_27_012757 393 34 author author NN 10_1101-2020_03_27_012757 393 35 / / SYM 10_1101-2020_03_27_012757 393 36 funder funder NN 10_1101-2020_03_27_012757 393 37 , , , 10_1101-2020_03_27_012757 393 38 who who WP 10_1101-2020_03_27_012757 393 39 has have VBZ 10_1101-2020_03_27_012757 393 40 granted grant VBN 10_1101-2020_03_27_012757 393 41 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 393 42 a a DT 10_1101-2020_03_27_012757 393 43 license license NN 10_1101-2020_03_27_012757 393 44 to to TO 10_1101-2020_03_27_012757 393 45 display display VB 10_1101-2020_03_27_012757 393 46 the the DT 10_1101-2020_03_27_012757 393 47 preprint preprint NN 10_1101-2020_03_27_012757 393 48 in in IN 10_1101-2020_03_27_012757 393 49 perpetuity perpetuity NN 10_1101-2020_03_27_012757 393 50 . . . 10_1101-2020_03_27_012757 394 1 It -PRON- PRP 10_1101-2020_03_27_012757 394 2 is be VBZ 10_1101-2020_03_27_012757 394 3 made make VBN 10_1101-2020_03_27_012757 394 4 The the DT 10_1101-2020_03_27_012757 394 5 copyright copyright NN 10_1101-2020_03_27_012757 394 6 holder holder NN 10_1101-2020_03_27_012757 394 7 for for IN 10_1101-2020_03_27_012757 394 8 this this DT 10_1101-2020_03_27_012757 394 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 394 10 version version NN 10_1101-2020_03_27_012757 394 11 posted post VBD 10_1101-2020_03_27_012757 394 12 January January NNP 10_1101-2020_03_27_012757 394 13 9 9 CD 10_1101-2020_03_27_012757 394 14 , , , 10_1101-2020_03_27_012757 394 15 2021 2021 CD 10_1101-2020_03_27_012757 394 16 . . . 10_1101-2020_03_27_012757 394 17 ; ; : 10_1101-2020_03_27_012757 394 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 394 19 : : : 10_1101-2020_03_27_012757 394 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 394 21 preprint preprint NN 10_1101-2020_03_27_012757 394 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 394 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ RB 10_1101-2020_03_27_012757 394 24 30 30 CD 10_1101-2020_03_27_012757 394 25 differentially differentially RB 10_1101-2020_03_27_012757 394 26 expressed express VBD 10_1101-2020_03_27_012757 394 27 genes gene NNS 10_1101-2020_03_27_012757 394 28 per per IN 10_1101-2020_03_27_012757 394 29 each each DT 10_1101-2020_03_27_012757 394 30 cancer cancer NN 10_1101-2020_03_27_012757 394 31 type type NN 10_1101-2020_03_27_012757 394 32 and and CC 10_1101-2020_03_27_012757 394 33 extracting extract VBG 10_1101-2020_03_27_012757 394 34 the the DT 10_1101-2020_03_27_012757 394 35 subnetwork subnetwork NN 10_1101-2020_03_27_012757 394 36 using use VBG 10_1101-2020_03_27_012757 394 37 those those DT 10_1101-2020_03_27_012757 394 38 780 780 CD 10_1101-2020_03_27_012757 394 39 genes gene NNS 10_1101-2020_03_27_012757 394 40 . . . 10_1101-2020_03_27_012757 395 1 781 781 CD 10_1101-2020_03_27_012757 395 2 To to TO 10_1101-2020_03_27_012757 395 3 extend extend VB 10_1101-2020_03_27_012757 395 4 the the DT 10_1101-2020_03_27_012757 395 5 original original JJ 10_1101-2020_03_27_012757 395 6 GRN GRN NNP 10_1101-2020_03_27_012757 395 7 status status NN 10_1101-2020_03_27_012757 395 8 algorithm21 algorithm21 VBN 10_1101-2020_03_27_012757 395 9 across across IN 10_1101-2020_03_27_012757 395 10 different different JJ 10_1101-2020_03_27_012757 395 11 platforms platform NNS 10_1101-2020_03_27_012757 395 12 and and CC 10_1101-2020_03_27_012757 395 13 species specie NNS 10_1101-2020_03_27_012757 395 14 , , , 10_1101-2020_03_27_012757 395 15 we -PRON- PRP 10_1101-2020_03_27_012757 395 16 782 782 CD 10_1101-2020_03_27_012757 395 17 devised devise VBD 10_1101-2020_03_27_012757 395 18 a a DT 10_1101-2020_03_27_012757 395 19 rank rank NN 10_1101-2020_03_27_012757 395 20 - - HYPH 10_1101-2020_03_27_012757 395 21 based base VBN 10_1101-2020_03_27_012757 395 22 GRN GRN NNP 10_1101-2020_03_27_012757 395 23 status status NN 10_1101-2020_03_27_012757 395 24 algorithm algorithm NNP 10_1101-2020_03_27_012757 395 25 . . . 10_1101-2020_03_27_012757 396 1 Like like IN 10_1101-2020_03_27_012757 396 2 the the DT 10_1101-2020_03_27_012757 396 3 original original JJ 10_1101-2020_03_27_012757 396 4 GRN GRN NNP 10_1101-2020_03_27_012757 396 5 status status NN 10_1101-2020_03_27_012757 396 6 , , , 10_1101-2020_03_27_012757 396 7 rank rank NN 10_1101-2020_03_27_012757 396 8 based base VBN 10_1101-2020_03_27_012757 396 9 GRN GRN NNP 10_1101-2020_03_27_012757 396 10 783 783 CD 10_1101-2020_03_27_012757 396 11 status status NN 10_1101-2020_03_27_012757 396 12 is be VBZ 10_1101-2020_03_27_012757 396 13 a a DT 10_1101-2020_03_27_012757 396 14 metric metric NN 10_1101-2020_03_27_012757 396 15 of of IN 10_1101-2020_03_27_012757 396 16 assessing assess VBG 10_1101-2020_03_27_012757 396 17 the the DT 10_1101-2020_03_27_012757 396 18 similarity similarity NN 10_1101-2020_03_27_012757 396 19 of of IN 10_1101-2020_03_27_012757 396 20 cancer cancer NN 10_1101-2020_03_27_012757 396 21 type type NN 10_1101-2020_03_27_012757 396 22 specific specific JJ 10_1101-2020_03_27_012757 396 23 GRN GRN NNP 10_1101-2020_03_27_012757 396 24 between between IN 10_1101-2020_03_27_012757 396 25 training train VBG 10_1101-2020_03_27_012757 396 26 data datum NNS 10_1101-2020_03_27_012757 396 27 784 784 CD 10_1101-2020_03_27_012757 396 28 in in IN 10_1101-2020_03_27_012757 396 29 the the DT 10_1101-2020_03_27_012757 396 30 cancer cancer NN 10_1101-2020_03_27_012757 396 31 type type NN 10_1101-2020_03_27_012757 396 32 of of IN 10_1101-2020_03_27_012757 396 33 interest interest NN 10_1101-2020_03_27_012757 396 34 and and CC 10_1101-2020_03_27_012757 396 35 query query NN 10_1101-2020_03_27_012757 396 36 samples sample NNS 10_1101-2020_03_27_012757 396 37 . . . 10_1101-2020_03_27_012757 397 1 Hence hence RB 10_1101-2020_03_27_012757 397 2 , , , 10_1101-2020_03_27_012757 397 3 high high JJ 10_1101-2020_03_27_012757 397 4 GRN GRN NNP 10_1101-2020_03_27_012757 397 5 status status NN 10_1101-2020_03_27_012757 397 6 represents represent VBZ 10_1101-2020_03_27_012757 397 7 high high JJ 10_1101-2020_03_27_012757 397 8 level level NN 10_1101-2020_03_27_012757 397 9 785 785 CD 10_1101-2020_03_27_012757 397 10 of of IN 10_1101-2020_03_27_012757 397 11 establishment establishment NN 10_1101-2020_03_27_012757 397 12 or or CC 10_1101-2020_03_27_012757 397 13 similarity similarity NN 10_1101-2020_03_27_012757 397 14 of of IN 10_1101-2020_03_27_012757 397 15 the the DT 10_1101-2020_03_27_012757 397 16 cancer cancer NN 10_1101-2020_03_27_012757 397 17 specific specific JJ 10_1101-2020_03_27_012757 397 18 GRN GRN NNP 10_1101-2020_03_27_012757 397 19 in in IN 10_1101-2020_03_27_012757 397 20 the the DT 10_1101-2020_03_27_012757 397 21 query query NN 10_1101-2020_03_27_012757 397 22 sample sample NN 10_1101-2020_03_27_012757 397 23 compared compare VBN 10_1101-2020_03_27_012757 397 24 to to IN 10_1101-2020_03_27_012757 397 25 those those DT 10_1101-2020_03_27_012757 397 26 786 786 CD 10_1101-2020_03_27_012757 397 27 of of IN 10_1101-2020_03_27_012757 397 28 the the DT 10_1101-2020_03_27_012757 397 29 training training NN 10_1101-2020_03_27_012757 397 30 data datum NNS 10_1101-2020_03_27_012757 397 31 . . . 10_1101-2020_03_27_012757 398 1 The the DT 10_1101-2020_03_27_012757 398 2 expression expression NN 10_1101-2020_03_27_012757 398 3 profiles profile NNS 10_1101-2020_03_27_012757 398 4 of of IN 10_1101-2020_03_27_012757 398 5 training train VBG 10_1101-2020_03_27_012757 398 6 data datum NNS 10_1101-2020_03_27_012757 398 7 and and CC 10_1101-2020_03_27_012757 398 8 query query NN 10_1101-2020_03_27_012757 398 9 data datum NNS 10_1101-2020_03_27_012757 398 10 were be VBD 10_1101-2020_03_27_012757 398 11 transformed transform VBN 10_1101-2020_03_27_012757 398 12 787 787 CD 10_1101-2020_03_27_012757 398 13 into into IN 10_1101-2020_03_27_012757 398 14 rank rank NN 10_1101-2020_03_27_012757 398 15 expression expression NN 10_1101-2020_03_27_012757 398 16 profiles profile NNS 10_1101-2020_03_27_012757 398 17 by by IN 10_1101-2020_03_27_012757 398 18 replacing replace VBG 10_1101-2020_03_27_012757 398 19 the the DT 10_1101-2020_03_27_012757 398 20 expression expression NN 10_1101-2020_03_27_012757 398 21 values value NNS 10_1101-2020_03_27_012757 398 22 with with IN 10_1101-2020_03_27_012757 398 23 the the DT 10_1101-2020_03_27_012757 398 24 rank rank NN 10_1101-2020_03_27_012757 398 25 of of IN 10_1101-2020_03_27_012757 398 26 the the DT 10_1101-2020_03_27_012757 398 27 expression expression NN 10_1101-2020_03_27_012757 398 28 788 788 CD 10_1101-2020_03_27_012757 398 29 values value NNS 10_1101-2020_03_27_012757 398 30 within within IN 10_1101-2020_03_27_012757 398 31 a a DT 10_1101-2020_03_27_012757 398 32 sample sample NN 10_1101-2020_03_27_012757 398 33 ( ( -LRB- 10_1101-2020_03_27_012757 398 34 highest high JJS 10_1101-2020_03_27_012757 398 35 expressed express VBN 10_1101-2020_03_27_012757 398 36 gene gene NN 10_1101-2020_03_27_012757 398 37 would would MD 10_1101-2020_03_27_012757 398 38 have have VB 10_1101-2020_03_27_012757 398 39 the the DT 10_1101-2020_03_27_012757 398 40 highest high JJS 10_1101-2020_03_27_012757 398 41 rank rank NN 10_1101-2020_03_27_012757 398 42 and and CC 10_1101-2020_03_27_012757 398 43 lowest low JJS 10_1101-2020_03_27_012757 398 44 789 789 CD 10_1101-2020_03_27_012757 398 45 expressed express VBN 10_1101-2020_03_27_012757 398 46 genes gene NNS 10_1101-2020_03_27_012757 398 47 would would MD 10_1101-2020_03_27_012757 398 48 have have VB 10_1101-2020_03_27_012757 398 49 a a DT 10_1101-2020_03_27_012757 398 50 rank rank NN 10_1101-2020_03_27_012757 398 51 of of IN 10_1101-2020_03_27_012757 398 52 1 1 CD 10_1101-2020_03_27_012757 398 53 ) ) -RRB- 10_1101-2020_03_27_012757 398 54 . . . 10_1101-2020_03_27_012757 399 1 Cancer cancer NN 10_1101-2020_03_27_012757 399 2 type type NN 10_1101-2020_03_27_012757 399 3 specific specific JJ 10_1101-2020_03_27_012757 399 4 mean mean JJ 10_1101-2020_03_27_012757 399 5 and and CC 10_1101-2020_03_27_012757 399 6 standard standard JJ 10_1101-2020_03_27_012757 399 7 deviation deviation NN 10_1101-2020_03_27_012757 399 8 of of IN 10_1101-2020_03_27_012757 399 9 790 790 CD 10_1101-2020_03_27_012757 399 10 every every DT 10_1101-2020_03_27_012757 399 11 gene gene NN 10_1101-2020_03_27_012757 399 12 ’s ’s POS 10_1101-2020_03_27_012757 399 13 rank rank NN 10_1101-2020_03_27_012757 399 14 expression expression NN 10_1101-2020_03_27_012757 399 15 were be VBD 10_1101-2020_03_27_012757 399 16 learned learn VBN 10_1101-2020_03_27_012757 399 17 from from IN 10_1101-2020_03_27_012757 399 18 training training NN 10_1101-2020_03_27_012757 399 19 data datum NNS 10_1101-2020_03_27_012757 399 20 . . . 10_1101-2020_03_27_012757 400 1 The the DT 10_1101-2020_03_27_012757 400 2 modified modified JJ 10_1101-2020_03_27_012757 400 3 Z z NN 10_1101-2020_03_27_012757 400 4 - - HYPH 10_1101-2020_03_27_012757 400 5 score score NN 10_1101-2020_03_27_012757 400 6 values value NNS 10_1101-2020_03_27_012757 400 7 for for IN 10_1101-2020_03_27_012757 400 8 791 791 CD 10_1101-2020_03_27_012757 400 9 genes gene NNS 10_1101-2020_03_27_012757 400 10 within within IN 10_1101-2020_03_27_012757 400 11 cancer cancer NN 10_1101-2020_03_27_012757 400 12 type type NN 10_1101-2020_03_27_012757 400 13 specific specific JJ 10_1101-2020_03_27_012757 400 14 GRN GRN NNP 10_1101-2020_03_27_012757 400 15 were be VBD 10_1101-2020_03_27_012757 400 16 calculated calculate VBN 10_1101-2020_03_27_012757 400 17 for for IN 10_1101-2020_03_27_012757 400 18 query query NNP 10_1101-2020_03_27_012757 400 19 sample sample NNP 10_1101-2020_03_27_012757 400 20 ’s ’s POS 10_1101-2020_03_27_012757 400 21 rank rank NNP 10_1101-2020_03_27_012757 400 22 expression expression NN 10_1101-2020_03_27_012757 400 23 792 792 CD 10_1101-2020_03_27_012757 400 24 profiles profile NNS 10_1101-2020_03_27_012757 400 25 to to TO 10_1101-2020_03_27_012757 400 26 quantify quantify VB 10_1101-2020_03_27_012757 400 27 how how WRB 10_1101-2020_03_27_012757 400 28 dissimilar dissimilar JJ 10_1101-2020_03_27_012757 400 29 the the DT 10_1101-2020_03_27_012757 400 30 expression expression NN 10_1101-2020_03_27_012757 400 31 values value NNS 10_1101-2020_03_27_012757 400 32 of of IN 10_1101-2020_03_27_012757 400 33 genes gene NNS 10_1101-2020_03_27_012757 400 34 in in IN 10_1101-2020_03_27_012757 400 35 query query NNP 10_1101-2020_03_27_012757 400 36 sample sample NN 10_1101-2020_03_27_012757 400 37 ’s ’s POS 10_1101-2020_03_27_012757 400 38 cancer cancer NN 10_1101-2020_03_27_012757 400 39 type type NN 10_1101-2020_03_27_012757 400 40 793 793 CD 10_1101-2020_03_27_012757 400 41 specific specific JJ 10_1101-2020_03_27_012757 400 42 GRN GRN NNP 10_1101-2020_03_27_012757 400 43 compared compare VBN 10_1101-2020_03_27_012757 400 44 to to IN 10_1101-2020_03_27_012757 400 45 those those DT 10_1101-2020_03_27_012757 400 46 of of IN 10_1101-2020_03_27_012757 400 47 the the DT 10_1101-2020_03_27_012757 400 48 reference reference NN 10_1101-2020_03_27_012757 400 49 training training NN 10_1101-2020_03_27_012757 400 50 data datum NNS 10_1101-2020_03_27_012757 400 51 : : : 10_1101-2020_03_27_012757 400 52 794 794 CD 10_1101-2020_03_27_012757 400 53 𝑍𝑠𝑐𝑜𝑟𝑒(𝑔𝑒𝑛𝑒 𝑍𝑠𝑐𝑜𝑟𝑒(𝑔𝑒𝑛𝑒 CD 10_1101-2020_03_27_012757 400 54 𝑖)XYZ 𝑖)XYZ NNS 10_1101-2020_03_27_012757 400 55 = = SYM 10_1101-2020_03_27_012757 400 56 [ [ -LRB- 10_1101-2020_03_27_012757 400 57 0 0 CD 10_1101-2020_03_27_012757 400 58 , , , 10_1101-2020_03_27_012757 400 59 𝑖𝑓 𝑖𝑓 NNP 10_1101-2020_03_27_012757 400 60 𝑍𝑠𝑐𝑜𝑟𝑒 𝑍𝑠𝑐𝑜𝑟𝑒 NNP 10_1101-2020_03_27_012757 400 61 𝑖𝑠 𝑖𝑠 XX 10_1101-2020_03_27_012757 400 62 𝑝𝑜𝑠𝑖𝑡𝑖𝑣𝑒 𝑝𝑜𝑠𝑖𝑡𝑖𝑣𝑒 NNP 10_1101-2020_03_27_012757 400 63 𝑎𝑛𝑑 𝑎𝑛𝑑 NNP 10_1101-2020_03_27_012757 400 64 𝑡ℎ𝑒 𝑡ℎ𝑒 NNP 10_1101-2020_03_27_012757 400 65 𝑔𝑒𝑛𝑒 𝑔𝑒𝑛𝑒 NNP 10_1101-2020_03_27_012757 400 66 𝑖𝑠 𝑖𝑠 NNP 10_1101-2020_03_27_012757 400 67 𝑓𝑜𝑢𝑛𝑑 𝑓𝑜𝑢𝑛𝑑 NNP 10_1101-2020_03_27_012757 400 68 𝑡𝑜 𝑡𝑜 NNP 10_1101-2020_03_27_012757 400 69 𝑏𝑒 𝑏𝑒 NNP 10_1101-2020_03_27_012757 400 70 𝑢𝑝𝑟𝑒𝑔𝑢𝑙𝑎𝑡𝑒𝑑 𝑢𝑝𝑟𝑒𝑔𝑢𝑙𝑎𝑡𝑒𝑑 NNP 10_1101-2020_03_27_012757 400 71 0 0 CD 10_1101-2020_03_27_012757 400 72 , , , 10_1101-2020_03_27_012757 400 73 𝑖𝑓 𝑖𝑓 NNP 10_1101-2020_03_27_012757 400 74 𝑍𝑠𝑐𝑜𝑟𝑒 𝑍𝑠𝑐𝑜𝑟𝑒 NNP 10_1101-2020_03_27_012757 400 75 𝑖𝑠 𝑖𝑠 IN 10_1101-2020_03_27_012757 400 76 𝑛𝑒𝑔𝑎𝑡𝑖𝑣𝑒 𝑛𝑒𝑔𝑎𝑡𝑖𝑣𝑒 NNP 10_1101-2020_03_27_012757 400 77 𝑎𝑛𝑑 𝑎𝑛𝑑 NNP 10_1101-2020_03_27_012757 400 78 𝑡ℎ𝑒 𝑡ℎ𝑒 NNP 10_1101-2020_03_27_012757 400 79 𝑔𝑒𝑛𝑒 𝑔𝑒𝑛𝑒 NNP 10_1101-2020_03_27_012757 400 80 𝑖𝑠 𝑖𝑠 NNP 10_1101-2020_03_27_012757 400 81 𝑓𝑜𝑢𝑛𝑑 𝑓𝑜𝑢𝑛𝑑 NNP 10_1101-2020_03_27_012757 400 82 𝑡𝑜 𝑡𝑜 NNP 10_1101-2020_03_27_012757 400 83 𝑏𝑒 𝑏𝑒 NNP 10_1101-2020_03_27_012757 400 84 𝑑𝑜𝑤𝑛𝑟𝑒𝑔𝑢𝑙𝑎𝑡𝑒𝑑 𝑑𝑜𝑤𝑛𝑟𝑒𝑔𝑢𝑙𝑎𝑡𝑒𝑑 NNP 10_1101-2020_03_27_012757 400 85 𝑎𝑏𝑠(𝑍𝑠𝑐𝑜𝑟𝑒 𝑎𝑏𝑠(𝑍𝑠𝑐𝑜𝑟𝑒 NNP 10_1101-2020_03_27_012757 400 86 ) ) -RRB- 10_1101-2020_03_27_012757 400 87 , , , 10_1101-2020_03_27_012757 400 88 𝑜𝑡ℎ𝑒𝑟𝑤𝑖𝑠𝑒 𝑜𝑡ℎ𝑒𝑟𝑤𝑖𝑠𝑒 VB 10_1101-2020_03_27_012757 400 89 795 795 CD 10_1101-2020_03_27_012757 400 90 If if IN 10_1101-2020_03_27_012757 400 91 a a DT 10_1101-2020_03_27_012757 400 92 gene gene NN 10_1101-2020_03_27_012757 400 93 in in IN 10_1101-2020_03_27_012757 400 94 the the DT 10_1101-2020_03_27_012757 400 95 cancer cancer NN 10_1101-2020_03_27_012757 400 96 type type NN 10_1101-2020_03_27_012757 400 97 specific specific JJ 10_1101-2020_03_27_012757 400 98 GRN GRN NNP 10_1101-2020_03_27_012757 400 99 is be VBZ 10_1101-2020_03_27_012757 400 100 found find VBN 10_1101-2020_03_27_012757 400 101 to to TO 10_1101-2020_03_27_012757 400 102 be be VB 10_1101-2020_03_27_012757 400 103 upregulated upregulate VBN 10_1101-2020_03_27_012757 400 104 in in IN 10_1101-2020_03_27_012757 400 105 the the DT 10_1101-2020_03_27_012757 400 106 specific specific JJ 10_1101-2020_03_27_012757 400 107 796 796 CD 10_1101-2020_03_27_012757 400 108 cancer cancer NN 10_1101-2020_03_27_012757 400 109 type type NN 10_1101-2020_03_27_012757 400 110 relative relative JJ 10_1101-2020_03_27_012757 400 111 to to IN 10_1101-2020_03_27_012757 400 112 other other JJ 10_1101-2020_03_27_012757 400 113 cancer cancer NN 10_1101-2020_03_27_012757 400 114 types type NNS 10_1101-2020_03_27_012757 400 115 , , , 10_1101-2020_03_27_012757 400 116 then then RB 10_1101-2020_03_27_012757 400 117 we -PRON- PRP 10_1101-2020_03_27_012757 400 118 would would MD 10_1101-2020_03_27_012757 400 119 consider consider VB 10_1101-2020_03_27_012757 400 120 query query NNP 10_1101-2020_03_27_012757 400 121 sample sample NNP 10_1101-2020_03_27_012757 400 122 ’s ’s POS 10_1101-2020_03_27_012757 400 123 gene gene NN 10_1101-2020_03_27_012757 400 124 to to TO 10_1101-2020_03_27_012757 400 125 be be VB 10_1101-2020_03_27_012757 400 126 797 797 CD 10_1101-2020_03_27_012757 400 127 similar similar JJ 10_1101-2020_03_27_012757 400 128 if if IN 10_1101-2020_03_27_012757 400 129 the the DT 10_1101-2020_03_27_012757 400 130 ranking ranking NN 10_1101-2020_03_27_012757 400 131 of of IN 10_1101-2020_03_27_012757 400 132 the the DT 10_1101-2020_03_27_012757 400 133 query query NN 10_1101-2020_03_27_012757 400 134 sample sample NN 10_1101-2020_03_27_012757 400 135 ’s ’s NNP 10_1101-2020_03_27_012757 400 136 gene gene NN 10_1101-2020_03_27_012757 400 137 is be VBZ 10_1101-2020_03_27_012757 400 138 equal equal JJ 10_1101-2020_03_27_012757 400 139 to to IN 10_1101-2020_03_27_012757 400 140 or or CC 10_1101-2020_03_27_012757 400 141 greater great JJR 10_1101-2020_03_27_012757 400 142 than than IN 10_1101-2020_03_27_012757 400 143 the the DT 10_1101-2020_03_27_012757 400 144 mean mean NN 10_1101-2020_03_27_012757 400 145 ranking ranking NN 10_1101-2020_03_27_012757 400 146 of of IN 10_1101-2020_03_27_012757 400 147 798 798 CD 10_1101-2020_03_27_012757 400 148 the the DT 10_1101-2020_03_27_012757 400 149 gene gene NN 10_1101-2020_03_27_012757 400 150 in in IN 10_1101-2020_03_27_012757 400 151 training training NN 10_1101-2020_03_27_012757 400 152 sample sample NN 10_1101-2020_03_27_012757 400 153 . . . 10_1101-2020_03_27_012757 401 1 As as IN 10_1101-2020_03_27_012757 401 2 a a DT 10_1101-2020_03_27_012757 401 3 result result NN 10_1101-2020_03_27_012757 401 4 of of IN 10_1101-2020_03_27_012757 401 5 similarity similarity NN 10_1101-2020_03_27_012757 401 6 , , , 10_1101-2020_03_27_012757 401 7 we -PRON- PRP 10_1101-2020_03_27_012757 401 8 assign assign VBP 10_1101-2020_03_27_012757 401 9 that that DT 10_1101-2020_03_27_012757 401 10 gene gene NN 10_1101-2020_03_27_012757 401 11 of of IN 10_1101-2020_03_27_012757 401 12 a a DT 10_1101-2020_03_27_012757 401 13 Z z NN 10_1101-2020_03_27_012757 401 14 - - HYPH 10_1101-2020_03_27_012757 401 15 score score NN 10_1101-2020_03_27_012757 401 16 of of IN 10_1101-2020_03_27_012757 401 17 0 0 CD 10_1101-2020_03_27_012757 401 18 . . . 10_1101-2020_03_27_012757 402 1 The the DT 10_1101-2020_03_27_012757 402 2 799 799 CD 10_1101-2020_03_27_012757 402 3 same same JJ 10_1101-2020_03_27_012757 402 4 principle principle NN 10_1101-2020_03_27_012757 402 5 applies apply VBZ 10_1101-2020_03_27_012757 402 6 to to IN 10_1101-2020_03_27_012757 402 7 cases case NNS 10_1101-2020_03_27_012757 402 8 where where WRB 10_1101-2020_03_27_012757 402 9 the the DT 10_1101-2020_03_27_012757 402 10 gene gene NN 10_1101-2020_03_27_012757 402 11 is be VBZ 10_1101-2020_03_27_012757 402 12 downregulated downregulate VBN 10_1101-2020_03_27_012757 402 13 in in IN 10_1101-2020_03_27_012757 402 14 cancer cancer NN 10_1101-2020_03_27_012757 402 15 specific specific JJ 10_1101-2020_03_27_012757 402 16 subnetwork subnetwork NN 10_1101-2020_03_27_012757 402 17 . . . 10_1101-2020_03_27_012757 403 1 800 800 CD 10_1101-2020_03_27_012757 403 2 GRN GRN NNP 10_1101-2020_03_27_012757 403 3 status status NN 10_1101-2020_03_27_012757 403 4 for for IN 10_1101-2020_03_27_012757 403 5 query query NN 10_1101-2020_03_27_012757 403 6 sample sample NN 10_1101-2020_03_27_012757 403 7 is be VBZ 10_1101-2020_03_27_012757 403 8 calculated calculate VBN 10_1101-2020_03_27_012757 403 9 as as IN 10_1101-2020_03_27_012757 403 10 the the DT 10_1101-2020_03_27_012757 403 11 weighted weighted JJ 10_1101-2020_03_27_012757 403 12 mean mean NN 10_1101-2020_03_27_012757 403 13 of of IN 10_1101-2020_03_27_012757 403 14 the the DT 10_1101-2020_03_27_012757 403 15 801 801 CD 10_1101-2020_03_27_012757 403 16 ( ( -LRB- 10_1101-2020_03_27_012757 403 17 1000 1000 CD 10_1101-2020_03_27_012757 403 18 − − NNP 10_1101-2020_03_27_012757 403 19 𝑍𝑠𝑐𝑜𝑟𝑒(𝑔𝑒𝑛𝑒 𝑍𝑠𝑐𝑜𝑟𝑒(𝑔𝑒𝑛𝑒 CD 10_1101-2020_03_27_012757 403 20 𝑖)XYZ 𝑖)XYZ NNP 10_1101-2020_03_27_012757 403 21 ) ) -RRB- 10_1101-2020_03_27_012757 403 22 across across IN 10_1101-2020_03_27_012757 403 23 genes gene NNS 10_1101-2020_03_27_012757 403 24 in in IN 10_1101-2020_03_27_012757 403 25 cancer cancer NN 10_1101-2020_03_27_012757 403 26 type type NN 10_1101-2020_03_27_012757 403 27 specific specific JJ 10_1101-2020_03_27_012757 403 28 GRN GRN NNP 10_1101-2020_03_27_012757 403 29 . . . 10_1101-2020_03_27_012757 404 1 1000 1000 CD 10_1101-2020_03_27_012757 404 2 is be VBZ 10_1101-2020_03_27_012757 404 3 an an DT 10_1101-2020_03_27_012757 404 4 arbitrary arbitrary JJ 10_1101-2020_03_27_012757 404 5 802 802 CD 10_1101-2020_03_27_012757 404 6 .CC .CC : 10_1101-2020_03_27_012757 404 7 - - HYPH 10_1101-2020_03_27_012757 404 8 BY by IN 10_1101-2020_03_27_012757 404 9 - - HYPH 10_1101-2020_03_27_012757 404 10 NC NC NNP 10_1101-2020_03_27_012757 404 11 - - HYPH 10_1101-2020_03_27_012757 404 12 ND ND NNP 10_1101-2020_03_27_012757 404 13 4.0 4.0 CD 10_1101-2020_03_27_012757 404 14 International International NNP 10_1101-2020_03_27_012757 404 15 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 404 16 under under IN 10_1101-2020_03_27_012757 404 17 a a DT 10_1101-2020_03_27_012757 404 18 ( ( -LRB- 10_1101-2020_03_27_012757 404 19 which which WDT 10_1101-2020_03_27_012757 404 20 was be VBD 10_1101-2020_03_27_012757 404 21 not not RB 10_1101-2020_03_27_012757 404 22 certified certify VBN 10_1101-2020_03_27_012757 404 23 by by IN 10_1101-2020_03_27_012757 404 24 peer peer NN 10_1101-2020_03_27_012757 404 25 review review NN 10_1101-2020_03_27_012757 404 26 ) ) -RRB- 10_1101-2020_03_27_012757 404 27 is be VBZ 10_1101-2020_03_27_012757 404 28 the the DT 10_1101-2020_03_27_012757 404 29 author author NN 10_1101-2020_03_27_012757 404 30 / / SYM 10_1101-2020_03_27_012757 404 31 funder funder NN 10_1101-2020_03_27_012757 404 32 , , , 10_1101-2020_03_27_012757 404 33 who who WP 10_1101-2020_03_27_012757 404 34 has have VBZ 10_1101-2020_03_27_012757 404 35 granted grant VBN 10_1101-2020_03_27_012757 404 36 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 404 37 a a DT 10_1101-2020_03_27_012757 404 38 license license NN 10_1101-2020_03_27_012757 404 39 to to TO 10_1101-2020_03_27_012757 404 40 display display VB 10_1101-2020_03_27_012757 404 41 the the DT 10_1101-2020_03_27_012757 404 42 preprint preprint NN 10_1101-2020_03_27_012757 404 43 in in IN 10_1101-2020_03_27_012757 404 44 perpetuity perpetuity NN 10_1101-2020_03_27_012757 404 45 . . . 10_1101-2020_03_27_012757 405 1 It -PRON- PRP 10_1101-2020_03_27_012757 405 2 is be VBZ 10_1101-2020_03_27_012757 405 3 made make VBN 10_1101-2020_03_27_012757 405 4 The the DT 10_1101-2020_03_27_012757 405 5 copyright copyright NN 10_1101-2020_03_27_012757 405 6 holder holder NN 10_1101-2020_03_27_012757 405 7 for for IN 10_1101-2020_03_27_012757 405 8 this this DT 10_1101-2020_03_27_012757 405 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 405 10 version version NN 10_1101-2020_03_27_012757 405 11 posted post VBD 10_1101-2020_03_27_012757 405 12 January January NNP 10_1101-2020_03_27_012757 405 13 9 9 CD 10_1101-2020_03_27_012757 405 14 , , , 10_1101-2020_03_27_012757 405 15 2021 2021 CD 10_1101-2020_03_27_012757 405 16 . . . 10_1101-2020_03_27_012757 405 17 ; ; : 10_1101-2020_03_27_012757 405 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 405 19 : : : 10_1101-2020_03_27_012757 405 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 405 21 preprint preprint NN 10_1101-2020_03_27_012757 405 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 405 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ RB 10_1101-2020_03_27_012757 405 24 31 31 CD 10_1101-2020_03_27_012757 405 25 large large JJ 10_1101-2020_03_27_012757 405 26 number number NN 10_1101-2020_03_27_012757 405 27 , , , 10_1101-2020_03_27_012757 405 28 and and CC 10_1101-2020_03_27_012757 405 29 larger large JJR 10_1101-2020_03_27_012757 405 30 dissimilarity dissimilarity NN 10_1101-2020_03_27_012757 405 31 between between IN 10_1101-2020_03_27_012757 405 32 query query NN 10_1101-2020_03_27_012757 405 33 ’s ’s POS 10_1101-2020_03_27_012757 405 34 cancer cancer NN 10_1101-2020_03_27_012757 405 35 type type NN 10_1101-2020_03_27_012757 405 36 specific specific JJ 10_1101-2020_03_27_012757 405 37 GRN GRN NNP 10_1101-2020_03_27_012757 405 38 indicate indicate VBP 10_1101-2020_03_27_012757 405 39 high high JJ 10_1101-2020_03_27_012757 405 40 803 803 CD 10_1101-2020_03_27_012757 405 41 Z z NN 10_1101-2020_03_27_012757 405 42 - - HYPH 10_1101-2020_03_27_012757 405 43 scores score NNS 10_1101-2020_03_27_012757 405 44 for for IN 10_1101-2020_03_27_012757 405 45 the the DT 10_1101-2020_03_27_012757 405 46 GRN GRN NNP 10_1101-2020_03_27_012757 405 47 genes gene NNS 10_1101-2020_03_27_012757 405 48 and and CC 10_1101-2020_03_27_012757 405 49 low low JJ 10_1101-2020_03_27_012757 405 50 GRN GRN NNP 10_1101-2020_03_27_012757 405 51 status status NN 10_1101-2020_03_27_012757 405 52 . . . 10_1101-2020_03_27_012757 406 1 804 804 CD 10_1101-2020_03_27_012757 406 2 𝑅𝐺𝑆 𝑅𝐺𝑆 NNP 10_1101-2020_03_27_012757 406 3 = = SYM 10_1101-2020_03_27_012757 406 4 e(1000 e(1000 CD 10_1101-2020_03_27_012757 406 5 − − NNP 10_1101-2020_03_27_012757 406 6 𝑍𝑠𝑐𝑜𝑟𝑒(𝑔𝑒𝑛𝑒 𝑍𝑠𝑐𝑜𝑟𝑒(𝑔𝑒𝑛𝑒 NNP 10_1101-2020_03_27_012757 406 7 𝑖)XYZ)𝑤𝑒𝑖𝑔ℎ𝑡fghg 𝑖)xyz)𝑤𝑒𝑖𝑔ℎ𝑡fghg NN 10_1101-2020_03_27_012757 406 8 i i NN 10_1101-2020_03_27_012757 406 9 h h NN 10_1101-2020_03_27_012757 406 10 ijk ijk VBP 10_1101-2020_03_27_012757 406 11 805 805 CD 10_1101-2020_03_27_012757 406 12 𝐺𝑅𝑁 𝐺𝑅𝑁 NNP 10_1101-2020_03_27_012757 406 13 𝑆𝑡𝑎𝑡𝑢𝑠 𝑆𝑡𝑎𝑡𝑢𝑠 NNP 10_1101-2020_03_27_012757 406 14 = = SYM 10_1101-2020_03_27_012757 406 15 𝑅𝐺𝑆 𝑅𝐺𝑆 NNP 10_1101-2020_03_27_012757 406 16 ∑ ∑ . 10_1101-2020_03_27_012757 406 17 𝑤𝑒𝑖𝑔ℎ𝑡fghg 𝑤𝑒𝑖𝑔ℎ𝑡fghg NNP 10_1101-2020_03_27_012757 406 18 ihijk ihijk NNP 10_1101-2020_03_27_012757 406 19 806 806 CD 10_1101-2020_03_27_012757 406 20 The the DT 10_1101-2020_03_27_012757 406 21 weight weight NN 10_1101-2020_03_27_012757 406 22 of of IN 10_1101-2020_03_27_012757 406 23 individual individual JJ 10_1101-2020_03_27_012757 406 24 genes gene NNS 10_1101-2020_03_27_012757 406 25 in in IN 10_1101-2020_03_27_012757 406 26 the the DT 10_1101-2020_03_27_012757 406 27 cancer cancer NN 10_1101-2020_03_27_012757 406 28 specific specific JJ 10_1101-2020_03_27_012757 406 29 network network NN 10_1101-2020_03_27_012757 406 30 is be VBZ 10_1101-2020_03_27_012757 406 31 determined determine VBN 10_1101-2020_03_27_012757 406 32 by by IN 10_1101-2020_03_27_012757 406 33 the the DT 10_1101-2020_03_27_012757 406 34 807 807 CD 10_1101-2020_03_27_012757 406 35 importance importance NN 10_1101-2020_03_27_012757 406 36 of of IN 10_1101-2020_03_27_012757 406 37 the the DT 10_1101-2020_03_27_012757 406 38 gene gene NN 10_1101-2020_03_27_012757 406 39 in in IN 10_1101-2020_03_27_012757 406 40 the the DT 10_1101-2020_03_27_012757 406 41 Random Random NNP 10_1101-2020_03_27_012757 406 42 Forest Forest NNP 10_1101-2020_03_27_012757 406 43 classifier classifier NN 10_1101-2020_03_27_012757 406 44 . . . 10_1101-2020_03_27_012757 407 1 Finally finally RB 10_1101-2020_03_27_012757 407 2 , , , 10_1101-2020_03_27_012757 407 3 the the DT 10_1101-2020_03_27_012757 407 4 GRN GRN NNP 10_1101-2020_03_27_012757 407 5 status status NN 10_1101-2020_03_27_012757 407 6 gets get VBZ 10_1101-2020_03_27_012757 407 7 normalized normalized JJ 10_1101-2020_03_27_012757 407 8 808 808 CD 10_1101-2020_03_27_012757 407 9 with with IN 10_1101-2020_03_27_012757 407 10 respect respect NN 10_1101-2020_03_27_012757 407 11 to to IN 10_1101-2020_03_27_012757 407 12 the the DT 10_1101-2020_03_27_012757 407 13 GRN GRN NNP 10_1101-2020_03_27_012757 407 14 status status NN 10_1101-2020_03_27_012757 407 15 of of IN 10_1101-2020_03_27_012757 407 16 the the DT 10_1101-2020_03_27_012757 407 17 cancer cancer NN 10_1101-2020_03_27_012757 407 18 type type NN 10_1101-2020_03_27_012757 407 19 of of IN 10_1101-2020_03_27_012757 407 20 interest interest NN 10_1101-2020_03_27_012757 407 21 and and CC 10_1101-2020_03_27_012757 407 22 the the DT 10_1101-2020_03_27_012757 407 23 cancer cancer NN 10_1101-2020_03_27_012757 407 24 type type NN 10_1101-2020_03_27_012757 407 25 with with IN 10_1101-2020_03_27_012757 407 26 the the DT 10_1101-2020_03_27_012757 407 27 lowest low JJS 10_1101-2020_03_27_012757 407 28 809 809 CD 10_1101-2020_03_27_012757 407 29 mean mean NN 10_1101-2020_03_27_012757 407 30 GRN GRN NNP 10_1101-2020_03_27_012757 407 31 status status NN 10_1101-2020_03_27_012757 407 32 . . . 10_1101-2020_03_27_012757 408 1 810 810 CD 10_1101-2020_03_27_012757 408 2 𝑁𝑜𝑟𝑚𝑎𝑙𝑖𝑧𝑒𝑑 𝑁𝑜𝑟𝑚𝑎𝑙𝑖𝑧𝑒𝑑 NNS 10_1101-2020_03_27_012757 408 3 𝐺𝑅𝑁 𝐺𝑅𝑁 RB 10_1101-2020_03_27_012757 408 4 𝑠𝑡𝑎𝑡𝑢𝑠 𝑠𝑡𝑎𝑡𝑢𝑠 NNS 10_1101-2020_03_27_012757 408 5 = = -RRB- 10_1101-2020_03_27_012757 408 6 𝐺𝑅𝑁 𝐺𝑅𝑁 RB 10_1101-2020_03_27_012757 408 7 𝑠𝑡𝑎𝑡𝑢𝑠 𝑠𝑡𝑎𝑡𝑢𝑠 NN 10_1101-2020_03_27_012757 408 8 mngop mngop NN 10_1101-2020_03_27_012757 408 9 − − NNP 10_1101-2020_03_27_012757 408 10 𝑎𝑣𝑔(𝐺𝑅𝑁 𝑎𝑣𝑔(𝐺𝑅𝑁 , 10_1101-2020_03_27_012757 408 11 𝑠𝑡𝑎𝑡𝑢𝑠 𝑠𝑡𝑎𝑡𝑢𝑠 JJ 10_1101-2020_03_27_012757 408 12 Xih Xih NNP 10_1101-2020_03_27_012757 408 13 qrhqgo qrhqgo NN 10_1101-2020_03_27_012757 408 14 ) ) -RRB- 10_1101-2020_03_27_012757 408 15 𝑎𝑣𝑔(𝐺𝑅𝑁 𝑎𝑣𝑔(𝐺𝑅𝑁 , 10_1101-2020_03_27_012757 408 16 𝑠𝑡𝑎𝑡𝑢𝑠qrhqgo 𝑠𝑡𝑎𝑡𝑢𝑠qrhqgo JJ 10_1101-2020_03_27_012757 408 17 sptg sptg NN 10_1101-2020_03_27_012757 408 18 ihsgogus ihsgogus JJ 10_1101-2020_03_27_012757 408 19 ) ) -RRB- 10_1101-2020_03_27_012757 408 20 811 811 CD 10_1101-2020_03_27_012757 408 21 Where where WRB 10_1101-2020_03_27_012757 408 22 “ " `` 10_1101-2020_03_27_012757 408 23 min min NNP 10_1101-2020_03_27_012757 408 24 cancer cancer NNP 10_1101-2020_03_27_012757 408 25 ” " '' 10_1101-2020_03_27_012757 408 26 represents represent VBZ 10_1101-2020_03_27_012757 408 27 the the DT 10_1101-2020_03_27_012757 408 28 cancer cancer NN 10_1101-2020_03_27_012757 408 29 type type NN 10_1101-2020_03_27_012757 408 30 where where WRB 10_1101-2020_03_27_012757 408 31 its -PRON- PRP$ 10_1101-2020_03_27_012757 408 32 training training NN 10_1101-2020_03_27_012757 408 33 data datum NNS 10_1101-2020_03_27_012757 408 34 have have VBP 10_1101-2020_03_27_012757 408 35 the the DT 10_1101-2020_03_27_012757 408 36 lowest low JJS 10_1101-2020_03_27_012757 408 37 812 812 CD 10_1101-2020_03_27_012757 408 38 mean mean JJ 10_1101-2020_03_27_012757 408 39 GRN GRN NNP 10_1101-2020_03_27_012757 408 40 status status NN 10_1101-2020_03_27_012757 408 41 in in IN 10_1101-2020_03_27_012757 408 42 the the DT 10_1101-2020_03_27_012757 408 43 cancer cancer NN 10_1101-2020_03_27_012757 408 44 type type NN 10_1101-2020_03_27_012757 408 45 of of IN 10_1101-2020_03_27_012757 408 46 interest interest NN 10_1101-2020_03_27_012757 408 47 , , , 10_1101-2020_03_27_012757 408 48 and and CC 10_1101-2020_03_27_012757 408 49 𝑎𝑣𝑔(𝐺𝑅𝑁 𝑎𝑣𝑔(𝐺𝑅𝑁 CD 10_1101-2020_03_27_012757 408 50 𝑠𝑡𝑎𝑡𝑢𝑠 𝑠𝑡𝑎𝑡𝑢𝑠 JJ 10_1101-2020_03_27_012757 408 51 Xih Xih NNP 10_1101-2020_03_27_012757 408 52 qrhqgo qrhqgo NN 10_1101-2020_03_27_012757 408 53 ) ) -RRB- 10_1101-2020_03_27_012757 408 54 represents represent VBZ 10_1101-2020_03_27_012757 408 55 the the DT 10_1101-2020_03_27_012757 408 56 813 813 CD 10_1101-2020_03_27_012757 408 57 lowest low JJS 10_1101-2020_03_27_012757 408 58 average average JJ 10_1101-2020_03_27_012757 408 59 GRN GRN NNP 10_1101-2020_03_27_012757 408 60 status status NN 10_1101-2020_03_27_012757 408 61 in in IN 10_1101-2020_03_27_012757 408 62 the the DT 10_1101-2020_03_27_012757 408 63 cancer cancer NN 10_1101-2020_03_27_012757 408 64 type type NN 10_1101-2020_03_27_012757 408 65 of of IN 10_1101-2020_03_27_012757 408 66 interest interest NN 10_1101-2020_03_27_012757 408 67 . . . 10_1101-2020_03_27_012757 409 1 𝑎𝑣𝑔(𝐺𝑅𝑁 𝑎𝑣𝑔(𝐺𝑅𝑁 `` 10_1101-2020_03_27_012757 409 2 𝑠𝑡𝑎𝑡𝑢𝑠qrhqgo 𝑠𝑡𝑎𝑡𝑢𝑠qrhqgo JJ 10_1101-2020_03_27_012757 409 3 sptg sptg NN 10_1101-2020_03_27_012757 409 4 ihsgogus ihsgogus JJ 10_1101-2020_03_27_012757 409 5 ) ) -RRB- 10_1101-2020_03_27_012757 409 6 814 814 CD 10_1101-2020_03_27_012757 409 7 represents represent VBZ 10_1101-2020_03_27_012757 409 8 average average JJ 10_1101-2020_03_27_012757 409 9 GRN GRN NNP 10_1101-2020_03_27_012757 409 10 status status NN 10_1101-2020_03_27_012757 409 11 of of IN 10_1101-2020_03_27_012757 409 12 the the DT 10_1101-2020_03_27_012757 409 13 cancer cancer NN 10_1101-2020_03_27_012757 409 14 type type NN 10_1101-2020_03_27_012757 409 15 of of IN 10_1101-2020_03_27_012757 409 16 interest interest NN 10_1101-2020_03_27_012757 409 17 in in IN 10_1101-2020_03_27_012757 409 18 the the DT 10_1101-2020_03_27_012757 409 19 training training NN 10_1101-2020_03_27_012757 409 20 data datum NNS 10_1101-2020_03_27_012757 409 21 . . . 10_1101-2020_03_27_012757 410 1 815 815 CD 10_1101-2020_03_27_012757 410 2 816 816 CD 10_1101-2020_03_27_012757 410 3 Code code NN 10_1101-2020_03_27_012757 410 4 availability availability NN 10_1101-2020_03_27_012757 410 5 817 817 CD 10_1101-2020_03_27_012757 410 6 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 410 7 code code NN 10_1101-2020_03_27_012757 410 8 and and CC 10_1101-2020_03_27_012757 410 9 documentation documentation NN 10_1101-2020_03_27_012757 410 10 is be VBZ 10_1101-2020_03_27_012757 410 11 available available JJ 10_1101-2020_03_27_012757 410 12 at at IN 10_1101-2020_03_27_012757 410 13 GitHub GitHub NNP 10_1101-2020_03_27_012757 410 14 : : : 10_1101-2020_03_27_012757 410 15 818 818 CD 10_1101-2020_03_27_012757 410 16 https://github.com/pcahan1/cancerCellNet https://github.com/pcahan1/cancerCellNet NNS 10_1101-2020_03_27_012757 410 17 819 819 CD 10_1101-2020_03_27_012757 410 18 820 820 CD 10_1101-2020_03_27_012757 410 19 Acknowledgements acknowledgement NNS 10_1101-2020_03_27_012757 410 20 821 821 CD 10_1101-2020_03_27_012757 410 21 This this DT 10_1101-2020_03_27_012757 410 22 work work NN 10_1101-2020_03_27_012757 410 23 was be VBD 10_1101-2020_03_27_012757 410 24 supported support VBN 10_1101-2020_03_27_012757 410 25 by by IN 10_1101-2020_03_27_012757 410 26 the the DT 10_1101-2020_03_27_012757 410 27 National National NNP 10_1101-2020_03_27_012757 410 28 Institutes Institutes NNPS 10_1101-2020_03_27_012757 410 29 of of IN 10_1101-2020_03_27_012757 410 30 Health Health NNP 10_1101-2020_03_27_012757 410 31 NCI NCI NNP 10_1101-2020_03_27_012757 410 32 Ovarian Ovarian NNP 10_1101-2020_03_27_012757 410 33 Cancer Cancer NNP 10_1101-2020_03_27_012757 410 34 SPORE SPORE NNP 10_1101-2020_03_27_012757 410 35 822 822 CD 10_1101-2020_03_27_012757 410 36 P50CA228991 p50ca228991 NN 10_1101-2020_03_27_012757 410 37 via via IN 10_1101-2020_03_27_012757 410 38 a a DT 10_1101-2020_03_27_012757 410 39 Development Development NNP 10_1101-2020_03_27_012757 410 40 Research Research NNP 10_1101-2020_03_27_012757 410 41 Program Program NNP 10_1101-2020_03_27_012757 410 42 award award NN 10_1101-2020_03_27_012757 410 43 to to IN 10_1101-2020_03_27_012757 410 44 PC PC NNP 10_1101-2020_03_27_012757 410 45 . . . 10_1101-2020_03_27_012757 411 1 FWH FWH NNP 10_1101-2020_03_27_012757 411 2 was be VBD 10_1101-2020_03_27_012757 411 3 supported support VBN 10_1101-2020_03_27_012757 411 4 by by IN 10_1101-2020_03_27_012757 411 5 a a DT 10_1101-2020_03_27_012757 411 6 823 823 CD 10_1101-2020_03_27_012757 411 7 Prostate Prostate NNP 10_1101-2020_03_27_012757 411 8 Cancer Cancer NNP 10_1101-2020_03_27_012757 411 9 Foundation Foundation NNP 10_1101-2020_03_27_012757 411 10 Young Young NNP 10_1101-2020_03_27_012757 411 11 Investigator Investigator NNP 10_1101-2020_03_27_012757 411 12 Award Award NNP 10_1101-2020_03_27_012757 411 13 , , , 10_1101-2020_03_27_012757 411 14 Department Department NNP 10_1101-2020_03_27_012757 411 15 of of IN 10_1101-2020_03_27_012757 411 16 Defense Defense NNP 10_1101-2020_03_27_012757 411 17 W81XWH-17 W81XWH-17 NNP 10_1101-2020_03_27_012757 411 18 - - HYPH 10_1101-2020_03_27_012757 411 19 824 824 CD 10_1101-2020_03_27_012757 411 20 PCRP pcrp NN 10_1101-2020_03_27_012757 411 21 - - HYPH 10_1101-2020_03_27_012757 411 22 HD HD NNP 10_1101-2020_03_27_012757 411 23 ( ( -LRB- 10_1101-2020_03_27_012757 411 24 F.W.H. F.W.H. NNP 10_1101-2020_03_27_012757 412 1 ) ) -RRB- 10_1101-2020_03_27_012757 412 2 , , , 10_1101-2020_03_27_012757 412 3 the the DT 10_1101-2020_03_27_012757 412 4 National National NNP 10_1101-2020_03_27_012757 412 5 Institutes Institutes NNPS 10_1101-2020_03_27_012757 412 6 of of IN 10_1101-2020_03_27_012757 412 7 Health Health NNP 10_1101-2020_03_27_012757 412 8 / / SYM 10_1101-2020_03_27_012757 412 9 National National NNP 10_1101-2020_03_27_012757 412 10 Cancer Cancer NNP 10_1101-2020_03_27_012757 412 11 Institute Institute NNP 10_1101-2020_03_27_012757 412 12 P20 P20 NNP 10_1101-2020_03_27_012757 412 13 CA233255 CA233255 NNP 10_1101-2020_03_27_012757 412 14 - - HYPH 10_1101-2020_03_27_012757 412 15 825 825 CD 10_1101-2020_03_27_012757 412 16 .CC .CC : 10_1101-2020_03_27_012757 412 17 - - HYPH 10_1101-2020_03_27_012757 412 18 BY by IN 10_1101-2020_03_27_012757 412 19 - - HYPH 10_1101-2020_03_27_012757 412 20 NC NC NNP 10_1101-2020_03_27_012757 412 21 - - HYPH 10_1101-2020_03_27_012757 412 22 ND ND NNP 10_1101-2020_03_27_012757 412 23 4.0 4.0 CD 10_1101-2020_03_27_012757 412 24 International International NNP 10_1101-2020_03_27_012757 412 25 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 412 26 under under IN 10_1101-2020_03_27_012757 412 27 a a DT 10_1101-2020_03_27_012757 412 28 ( ( -LRB- 10_1101-2020_03_27_012757 412 29 which which WDT 10_1101-2020_03_27_012757 412 30 was be VBD 10_1101-2020_03_27_012757 412 31 not not RB 10_1101-2020_03_27_012757 412 32 certified certify VBN 10_1101-2020_03_27_012757 412 33 by by IN 10_1101-2020_03_27_012757 412 34 peer peer NN 10_1101-2020_03_27_012757 412 35 review review NN 10_1101-2020_03_27_012757 412 36 ) ) -RRB- 10_1101-2020_03_27_012757 412 37 is be VBZ 10_1101-2020_03_27_012757 412 38 the the DT 10_1101-2020_03_27_012757 412 39 author author NN 10_1101-2020_03_27_012757 412 40 / / SYM 10_1101-2020_03_27_012757 412 41 funder funder NN 10_1101-2020_03_27_012757 412 42 , , , 10_1101-2020_03_27_012757 412 43 who who WP 10_1101-2020_03_27_012757 412 44 has have VBZ 10_1101-2020_03_27_012757 412 45 granted grant VBN 10_1101-2020_03_27_012757 412 46 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 412 47 a a DT 10_1101-2020_03_27_012757 412 48 license license NN 10_1101-2020_03_27_012757 412 49 to to TO 10_1101-2020_03_27_012757 412 50 display display VB 10_1101-2020_03_27_012757 412 51 the the DT 10_1101-2020_03_27_012757 412 52 preprint preprint NN 10_1101-2020_03_27_012757 412 53 in in IN 10_1101-2020_03_27_012757 412 54 perpetuity perpetuity NN 10_1101-2020_03_27_012757 412 55 . . . 10_1101-2020_03_27_012757 413 1 It -PRON- PRP 10_1101-2020_03_27_012757 413 2 is be VBZ 10_1101-2020_03_27_012757 413 3 made make VBN 10_1101-2020_03_27_012757 413 4 The the DT 10_1101-2020_03_27_012757 413 5 copyright copyright NN 10_1101-2020_03_27_012757 413 6 holder holder NN 10_1101-2020_03_27_012757 413 7 for for IN 10_1101-2020_03_27_012757 413 8 this this DT 10_1101-2020_03_27_012757 413 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 413 10 version version NN 10_1101-2020_03_27_012757 413 11 posted post VBD 10_1101-2020_03_27_012757 413 12 January January NNP 10_1101-2020_03_27_012757 413 13 9 9 CD 10_1101-2020_03_27_012757 413 14 , , , 10_1101-2020_03_27_012757 413 15 2021 2021 CD 10_1101-2020_03_27_012757 413 16 . . . 10_1101-2020_03_27_012757 413 17 ; ; : 10_1101-2020_03_27_012757 413 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 413 19 : : : 10_1101-2020_03_27_012757 413 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 413 21 preprint preprint NN 10_1101-2020_03_27_012757 413 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 413 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 413 24 32 32 CD 10_1101-2020_03_27_012757 413 25 01 01 CD 10_1101-2020_03_27_012757 413 26 ( ( -LRB- 10_1101-2020_03_27_012757 413 27 F.W.H. F.W.H. NNP 10_1101-2020_03_27_012757 413 28 ) ) -RRB- 10_1101-2020_03_27_012757 414 1 U19 U19 NNP 10_1101-2020_03_27_012757 414 2 CA214253 CA214253 . 10_1101-2020_03_27_012757 414 3 ( ( -LRB- 10_1101-2020_03_27_012757 414 4 F.W.H. F.W.H. NNP 10_1101-2020_03_27_012757 414 5 ) ) -RRB- 10_1101-2020_03_27_012757 414 6 . . . 10_1101-2020_03_27_012757 415 1 We -PRON- PRP 10_1101-2020_03_27_012757 415 2 would would MD 10_1101-2020_03_27_012757 415 3 like like VB 10_1101-2020_03_27_012757 415 4 to to TO 10_1101-2020_03_27_012757 415 5 thank thank VB 10_1101-2020_03_27_012757 415 6 John John NNP 10_1101-2020_03_27_012757 415 7 Powers Powers NNP 10_1101-2020_03_27_012757 415 8 , , , 10_1101-2020_03_27_012757 415 9 Hao Hao NNP 10_1101-2020_03_27_012757 415 10 Zhu Zhu NNP 10_1101-2020_03_27_012757 415 11 , , , 10_1101-2020_03_27_012757 415 12 Tian Tian NNP 10_1101-2020_03_27_012757 415 13 - - HYPH 10_1101-2020_03_27_012757 415 14 Li Li NNP 10_1101-2020_03_27_012757 415 15 826 826 CD 10_1101-2020_03_27_012757 415 16 Wang Wang NNP 10_1101-2020_03_27_012757 415 17 , , , 10_1101-2020_03_27_012757 415 18 Charles Charles NNP 10_1101-2020_03_27_012757 415 19 Eberhart Eberhart NNP 10_1101-2020_03_27_012757 415 20 , , , 10_1101-2020_03_27_012757 415 21 and and CC 10_1101-2020_03_27_012757 415 22 Kaloyan Kaloyan NNP 10_1101-2020_03_27_012757 415 23 Tsanov Tsanov NNP 10_1101-2020_03_27_012757 415 24 for for IN 10_1101-2020_03_27_012757 415 25 comments comment NNS 10_1101-2020_03_27_012757 415 26 on on IN 10_1101-2020_03_27_012757 415 27 the the DT 10_1101-2020_03_27_012757 415 28 manuscript manuscript NN 10_1101-2020_03_27_012757 415 29 and and CC 10_1101-2020_03_27_012757 415 30 helpful helpful JJ 10_1101-2020_03_27_012757 415 31 827 827 CD 10_1101-2020_03_27_012757 415 32 discussions discussion NNS 10_1101-2020_03_27_012757 415 33 . . . 10_1101-2020_03_27_012757 416 1 Some some DT 10_1101-2020_03_27_012757 416 2 figures figure NNS 10_1101-2020_03_27_012757 416 3 were be VBD 10_1101-2020_03_27_012757 416 4 created create VBN 10_1101-2020_03_27_012757 416 5 in in IN 10_1101-2020_03_27_012757 416 6 part part NN 10_1101-2020_03_27_012757 416 7 with with IN 10_1101-2020_03_27_012757 416 8 Biorender.com Biorender.com NNP 10_1101-2020_03_27_012757 416 9 . . . 10_1101-2020_03_27_012757 417 1 828 828 CD 10_1101-2020_03_27_012757 417 2 829 829 CD 10_1101-2020_03_27_012757 417 3 FIGURE figure NN 10_1101-2020_03_27_012757 417 4 LEGENDS legend NNS 10_1101-2020_03_27_012757 417 5 830 830 CD 10_1101-2020_03_27_012757 417 6 Fig fig NN 10_1101-2020_03_27_012757 417 7 . . . 10_1101-2020_03_27_012757 418 1 1 1 CD 10_1101-2020_03_27_012757 418 2 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 418 3 ( ( -LRB- 10_1101-2020_03_27_012757 418 4 CCN CCN NNP 10_1101-2020_03_27_012757 418 5 ) ) -RRB- 10_1101-2020_03_27_012757 418 6 workflow workflow NN 10_1101-2020_03_27_012757 418 7 , , , 10_1101-2020_03_27_012757 418 8 training training NN 10_1101-2020_03_27_012757 418 9 , , , 10_1101-2020_03_27_012757 418 10 and and CC 10_1101-2020_03_27_012757 418 11 performance performance NN 10_1101-2020_03_27_012757 418 12 . . . 10_1101-2020_03_27_012757 419 1 ( ( -LRB- 10_1101-2020_03_27_012757 419 2 A a DT 10_1101-2020_03_27_012757 419 3 ) ) -RRB- 10_1101-2020_03_27_012757 419 4 Schematic schematic JJ 10_1101-2020_03_27_012757 419 5 of of IN 10_1101-2020_03_27_012757 419 6 CCN CCN NNP 10_1101-2020_03_27_012757 419 7 831 831 CD 10_1101-2020_03_27_012757 419 8 usage usage NN 10_1101-2020_03_27_012757 419 9 . . . 10_1101-2020_03_27_012757 420 1 CCN CCN NNP 10_1101-2020_03_27_012757 420 2 was be VBD 10_1101-2020_03_27_012757 420 3 designed design VBN 10_1101-2020_03_27_012757 420 4 to to TO 10_1101-2020_03_27_012757 420 5 assess assess VB 10_1101-2020_03_27_012757 420 6 and and CC 10_1101-2020_03_27_012757 420 7 compare compare VB 10_1101-2020_03_27_012757 420 8 the the DT 10_1101-2020_03_27_012757 420 9 expression expression NN 10_1101-2020_03_27_012757 420 10 profiles profile NNS 10_1101-2020_03_27_012757 420 11 of of IN 10_1101-2020_03_27_012757 420 12 cancer cancer NN 10_1101-2020_03_27_012757 420 13 models model NNS 10_1101-2020_03_27_012757 420 14 832 832 CD 10_1101-2020_03_27_012757 420 15 such such JJ 10_1101-2020_03_27_012757 420 16 as as IN 10_1101-2020_03_27_012757 420 17 CCLs ccl NNS 10_1101-2020_03_27_012757 420 18 , , , 10_1101-2020_03_27_012757 420 19 PDXs pdx NNS 10_1101-2020_03_27_012757 420 20 , , , 10_1101-2020_03_27_012757 420 21 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 420 22 , , , 10_1101-2020_03_27_012757 420 23 and and CC 10_1101-2020_03_27_012757 420 24 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 420 25 with with IN 10_1101-2020_03_27_012757 420 26 native native JJ 10_1101-2020_03_27_012757 420 27 patient patient JJ 10_1101-2020_03_27_012757 420 28 tumors tumor NNS 10_1101-2020_03_27_012757 420 29 . . . 10_1101-2020_03_27_012757 421 1 To to TO 10_1101-2020_03_27_012757 421 2 use use VB 10_1101-2020_03_27_012757 421 3 trained train VBN 10_1101-2020_03_27_012757 421 4 833 833 CD 10_1101-2020_03_27_012757 421 5 classifier classifier NN 10_1101-2020_03_27_012757 421 6 , , , 10_1101-2020_03_27_012757 421 7 CCN CCN NNP 10_1101-2020_03_27_012757 421 8 inputs input VBZ 10_1101-2020_03_27_012757 421 9 the the DT 10_1101-2020_03_27_012757 421 10 query query NN 10_1101-2020_03_27_012757 421 11 samples sample NNS 10_1101-2020_03_27_012757 421 12 ( ( -LRB- 10_1101-2020_03_27_012757 421 13 e.g. e.g. RB 10_1101-2020_03_27_012757 422 1 expression expression NN 10_1101-2020_03_27_012757 422 2 profiles profile NNS 10_1101-2020_03_27_012757 422 3 from from IN 10_1101-2020_03_27_012757 422 4 CCLs CCLs NNP 10_1101-2020_03_27_012757 422 5 , , , 10_1101-2020_03_27_012757 422 6 PDXs pdx NNS 10_1101-2020_03_27_012757 422 7 , , , 10_1101-2020_03_27_012757 422 8 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 422 9 , , , 10_1101-2020_03_27_012757 422 10 834 834 CD 10_1101-2020_03_27_012757 422 11 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 422 12 ) ) -RRB- 10_1101-2020_03_27_012757 422 13 and and CC 10_1101-2020_03_27_012757 422 14 generates generate VBZ 10_1101-2020_03_27_012757 422 15 a a DT 10_1101-2020_03_27_012757 422 16 classification classification NN 10_1101-2020_03_27_012757 422 17 profile profile NN 10_1101-2020_03_27_012757 422 18 for for IN 10_1101-2020_03_27_012757 422 19 the the DT 10_1101-2020_03_27_012757 422 20 query query NN 10_1101-2020_03_27_012757 422 21 samples sample NNS 10_1101-2020_03_27_012757 422 22 . . . 10_1101-2020_03_27_012757 423 1 The the DT 10_1101-2020_03_27_012757 423 2 column column NN 10_1101-2020_03_27_012757 423 3 names name NNS 10_1101-2020_03_27_012757 423 4 of of IN 10_1101-2020_03_27_012757 423 5 835 835 CD 10_1101-2020_03_27_012757 423 6 the the DT 10_1101-2020_03_27_012757 423 7 classification classification NN 10_1101-2020_03_27_012757 423 8 heatmap heatmap NN 10_1101-2020_03_27_012757 423 9 represent represent VBP 10_1101-2020_03_27_012757 423 10 sample sample NN 10_1101-2020_03_27_012757 423 11 annotation annotation NN 10_1101-2020_03_27_012757 423 12 and and CC 10_1101-2020_03_27_012757 423 13 the the DT 10_1101-2020_03_27_012757 423 14 row row NN 10_1101-2020_03_27_012757 423 15 names name NNS 10_1101-2020_03_27_012757 423 16 of of IN 10_1101-2020_03_27_012757 423 17 the the DT 10_1101-2020_03_27_012757 423 18 classification classification NN 10_1101-2020_03_27_012757 423 19 836 836 CD 10_1101-2020_03_27_012757 423 20 heatmap heatmap NNP 10_1101-2020_03_27_012757 423 21 represent represent VBP 10_1101-2020_03_27_012757 423 22 different different JJ 10_1101-2020_03_27_012757 423 23 cancer cancer NN 10_1101-2020_03_27_012757 423 24 types type NNS 10_1101-2020_03_27_012757 423 25 . . . 10_1101-2020_03_27_012757 424 1 Each each DT 10_1101-2020_03_27_012757 424 2 grid grid NN 10_1101-2020_03_27_012757 424 3 is be VBZ 10_1101-2020_03_27_012757 424 4 colored color VBN 10_1101-2020_03_27_012757 424 5 from from IN 10_1101-2020_03_27_012757 424 6 black black JJ 10_1101-2020_03_27_012757 424 7 to to IN 10_1101-2020_03_27_012757 424 8 yellow yellow JJ 10_1101-2020_03_27_012757 424 9 representing represent VBG 10_1101-2020_03_27_012757 424 10 837 837 CD 10_1101-2020_03_27_012757 424 11 the the DT 10_1101-2020_03_27_012757 424 12 lowest low JJS 10_1101-2020_03_27_012757 424 13 classification classification NN 10_1101-2020_03_27_012757 424 14 score score NN 10_1101-2020_03_27_012757 424 15 ( ( -LRB- 10_1101-2020_03_27_012757 424 16 e.g. e.g. RB 10_1101-2020_03_27_012757 425 1 0 0 LS 10_1101-2020_03_27_012757 425 2 ) ) -RRB- 10_1101-2020_03_27_012757 425 3 to to IN 10_1101-2020_03_27_012757 425 4 highest high JJS 10_1101-2020_03_27_012757 425 5 classification classification NN 10_1101-2020_03_27_012757 425 6 score score NN 10_1101-2020_03_27_012757 425 7 ( ( -LRB- 10_1101-2020_03_27_012757 425 8 e.g. e.g. RB 10_1101-2020_03_27_012757 426 1 1 1 LS 10_1101-2020_03_27_012757 426 2 ) ) -RRB- 10_1101-2020_03_27_012757 426 3 . . . 10_1101-2020_03_27_012757 427 1 ( ( -LRB- 10_1101-2020_03_27_012757 427 2 B b NN 10_1101-2020_03_27_012757 427 3 ) ) -RRB- 10_1101-2020_03_27_012757 427 4 Schematic Schematic NNP 10_1101-2020_03_27_012757 427 5 of of IN 10_1101-2020_03_27_012757 427 6 838 838 CD 10_1101-2020_03_27_012757 427 7 CCN CCN NNP 10_1101-2020_03_27_012757 427 8 training training NN 10_1101-2020_03_27_012757 427 9 process process NN 10_1101-2020_03_27_012757 427 10 . . . 10_1101-2020_03_27_012757 428 1 CCN CCN NNP 10_1101-2020_03_27_012757 428 2 uses use VBZ 10_1101-2020_03_27_012757 428 3 patient patient JJ 10_1101-2020_03_27_012757 428 4 tumor tumor NN 10_1101-2020_03_27_012757 428 5 expression expression NN 10_1101-2020_03_27_012757 428 6 profiles profile NNS 10_1101-2020_03_27_012757 428 7 of of IN 10_1101-2020_03_27_012757 428 8 22 22 CD 10_1101-2020_03_27_012757 428 9 different different JJ 10_1101-2020_03_27_012757 428 10 cancer cancer NN 10_1101-2020_03_27_012757 428 11 types type NNS 10_1101-2020_03_27_012757 428 12 839 839 CD 10_1101-2020_03_27_012757 428 13 from from IN 10_1101-2020_03_27_012757 428 14 TCGA TCGA NNP 10_1101-2020_03_27_012757 428 15 as as IN 10_1101-2020_03_27_012757 428 16 training training NN 10_1101-2020_03_27_012757 428 17 data datum NNS 10_1101-2020_03_27_012757 428 18 . . . 10_1101-2020_03_27_012757 429 1 First first RB 10_1101-2020_03_27_012757 429 2 , , , 10_1101-2020_03_27_012757 429 3 CCN CCN NNP 10_1101-2020_03_27_012757 429 4 identifies identifie NNS 10_1101-2020_03_27_012757 429 5 n n CC 10_1101-2020_03_27_012757 429 6 genes gene NNS 10_1101-2020_03_27_012757 429 7 that that WDT 10_1101-2020_03_27_012757 429 8 are be VBP 10_1101-2020_03_27_012757 429 9 upregulated upregulate VBN 10_1101-2020_03_27_012757 429 10 , , , 10_1101-2020_03_27_012757 429 11 n n CC 10_1101-2020_03_27_012757 429 12 that that WDT 10_1101-2020_03_27_012757 429 13 are be VBP 10_1101-2020_03_27_012757 429 14 840 840 CD 10_1101-2020_03_27_012757 429 15 downregulated downregulate VBN 10_1101-2020_03_27_012757 429 16 , , , 10_1101-2020_03_27_012757 429 17 and and CC 10_1101-2020_03_27_012757 429 18 n n IN 10_1101-2020_03_27_012757 429 19 that that WDT 10_1101-2020_03_27_012757 429 20 are be VBP 10_1101-2020_03_27_012757 429 21 relatively relatively RB 10_1101-2020_03_27_012757 429 22 invariant invariant JJ 10_1101-2020_03_27_012757 429 23 in in IN 10_1101-2020_03_27_012757 429 24 each each DT 10_1101-2020_03_27_012757 429 25 tumor tumor NN 10_1101-2020_03_27_012757 429 26 type type NN 10_1101-2020_03_27_012757 429 27 versus versus IN 10_1101-2020_03_27_012757 429 28 all all DT 10_1101-2020_03_27_012757 429 29 of of IN 10_1101-2020_03_27_012757 429 30 the the DT 10_1101-2020_03_27_012757 429 31 others other NNS 10_1101-2020_03_27_012757 429 32 . . . 10_1101-2020_03_27_012757 430 1 841 841 CD 10_1101-2020_03_27_012757 430 2 Then then RB 10_1101-2020_03_27_012757 430 3 , , , 10_1101-2020_03_27_012757 430 4 CCN CCN NNP 10_1101-2020_03_27_012757 430 5 performs perform VBZ 10_1101-2020_03_27_012757 430 6 a a DT 10_1101-2020_03_27_012757 430 7 pair pair NN 10_1101-2020_03_27_012757 430 8 transform transform NN 10_1101-2020_03_27_012757 430 9 on on IN 10_1101-2020_03_27_012757 430 10 these these DT 10_1101-2020_03_27_012757 430 11 genes gene NNS 10_1101-2020_03_27_012757 430 12 and and CC 10_1101-2020_03_27_012757 430 13 subsequently subsequently RB 10_1101-2020_03_27_012757 430 14 selects select VBZ 10_1101-2020_03_27_012757 430 15 the the DT 10_1101-2020_03_27_012757 430 16 most most JJS 10_1101-2020_03_27_012757 430 17 842 842 CD 10_1101-2020_03_27_012757 430 18 discriminative discriminative JJ 10_1101-2020_03_27_012757 430 19 set set NN 10_1101-2020_03_27_012757 430 20 of of IN 10_1101-2020_03_27_012757 430 21 m m NN 10_1101-2020_03_27_012757 430 22 gene gene NN 10_1101-2020_03_27_012757 430 23 pairs pair NNS 10_1101-2020_03_27_012757 430 24 for for IN 10_1101-2020_03_27_012757 430 25 each each DT 10_1101-2020_03_27_012757 430 26 cancer cancer NN 10_1101-2020_03_27_012757 430 27 type type NN 10_1101-2020_03_27_012757 430 28 as as IN 10_1101-2020_03_27_012757 430 29 features feature NNS 10_1101-2020_03_27_012757 430 30 ( ( -LRB- 10_1101-2020_03_27_012757 430 31 or or CC 10_1101-2020_03_27_012757 430 32 predictors predictor NNS 10_1101-2020_03_27_012757 430 33 ) ) -RRB- 10_1101-2020_03_27_012757 430 34 for for IN 10_1101-2020_03_27_012757 430 35 the the DT 10_1101-2020_03_27_012757 430 36 843 843 CD 10_1101-2020_03_27_012757 430 37 Random random JJ 10_1101-2020_03_27_012757 430 38 forest forest NN 10_1101-2020_03_27_012757 430 39 classifier classifier NN 10_1101-2020_03_27_012757 430 40 . . . 10_1101-2020_03_27_012757 431 1 Lastly lastly RB 10_1101-2020_03_27_012757 431 2 , , , 10_1101-2020_03_27_012757 431 3 CCN CCN NNP 10_1101-2020_03_27_012757 431 4 trains train VBZ 10_1101-2020_03_27_012757 431 5 a a DT 10_1101-2020_03_27_012757 431 6 multi multi JJ 10_1101-2020_03_27_012757 431 7 - - JJ 10_1101-2020_03_27_012757 431 8 class class JJ 10_1101-2020_03_27_012757 431 9 Random Random NNP 10_1101-2020_03_27_012757 431 10 Forest Forest NNP 10_1101-2020_03_27_012757 431 11 classifier classifier NN 10_1101-2020_03_27_012757 431 12 using use VBG 10_1101-2020_03_27_012757 431 13 gene-844 gene-844 NNP 10_1101-2020_03_27_012757 431 14 pair pair NN 10_1101-2020_03_27_012757 431 15 transformed transform VBD 10_1101-2020_03_27_012757 431 16 training training NN 10_1101-2020_03_27_012757 431 17 data datum NNS 10_1101-2020_03_27_012757 431 18 . . . 10_1101-2020_03_27_012757 432 1 ( ( -LRB- 10_1101-2020_03_27_012757 432 2 C C NNP 10_1101-2020_03_27_012757 432 3 ) ) -RRB- 10_1101-2020_03_27_012757 432 4 Parameter parameter NN 10_1101-2020_03_27_012757 432 5 optimization optimization NN 10_1101-2020_03_27_012757 432 6 strategy strategy NN 10_1101-2020_03_27_012757 432 7 . . . 10_1101-2020_03_27_012757 433 1 5 5 CD 10_1101-2020_03_27_012757 433 2 cross cross NN 10_1101-2020_03_27_012757 433 3 - - NNS 10_1101-2020_03_27_012757 433 4 validations validation NNS 10_1101-2020_03_27_012757 433 5 of of IN 10_1101-2020_03_27_012757 433 6 each each DT 10_1101-2020_03_27_012757 433 7 845 845 CD 10_1101-2020_03_27_012757 433 8 parameter parameter NN 10_1101-2020_03_27_012757 433 9 set set VBN 10_1101-2020_03_27_012757 433 10 in in IN 10_1101-2020_03_27_012757 433 11 which which WDT 10_1101-2020_03_27_012757 433 12 2/3 2/3 CD 10_1101-2020_03_27_012757 433 13 of of IN 10_1101-2020_03_27_012757 433 14 TCGA TCGA NNP 10_1101-2020_03_27_012757 433 15 data datum NNS 10_1101-2020_03_27_012757 433 16 was be VBD 10_1101-2020_03_27_012757 433 17 used use VBN 10_1101-2020_03_27_012757 433 18 to to TO 10_1101-2020_03_27_012757 433 19 train train VB 10_1101-2020_03_27_012757 433 20 and and CC 10_1101-2020_03_27_012757 433 21 1/3 1/3 CD 10_1101-2020_03_27_012757 433 22 to to TO 10_1101-2020_03_27_012757 433 23 validate validate VB 10_1101-2020_03_27_012757 433 24 was be VBD 10_1101-2020_03_27_012757 433 25 used use VBN 10_1101-2020_03_27_012757 433 26 search search NN 10_1101-2020_03_27_012757 433 27 846 846 CD 10_1101-2020_03_27_012757 433 28 for for IN 10_1101-2020_03_27_012757 433 29 the the DT 10_1101-2020_03_27_012757 433 30 values value NNS 10_1101-2020_03_27_012757 433 31 of of IN 10_1101-2020_03_27_012757 433 32 n n NN 10_1101-2020_03_27_012757 433 33 and and CC 10_1101-2020_03_27_012757 433 34 m m NNP 10_1101-2020_03_27_012757 433 35 that that WDT 10_1101-2020_03_27_012757 433 36 maximized maximize VBD 10_1101-2020_03_27_012757 433 37 performance performance NN 10_1101-2020_03_27_012757 433 38 of of IN 10_1101-2020_03_27_012757 433 39 the the DT 10_1101-2020_03_27_012757 433 40 classifier classifier NN 10_1101-2020_03_27_012757 433 41 as as IN 10_1101-2020_03_27_012757 433 42 measured measure VBN 10_1101-2020_03_27_012757 433 43 by by IN 10_1101-2020_03_27_012757 433 44 area area NN 10_1101-2020_03_27_012757 433 45 847 847 CD 10_1101-2020_03_27_012757 433 46 under under IN 10_1101-2020_03_27_012757 433 47 the the DT 10_1101-2020_03_27_012757 433 48 precision precision NN 10_1101-2020_03_27_012757 433 49 recall recall NN 10_1101-2020_03_27_012757 433 50 curve curve NN 10_1101-2020_03_27_012757 433 51 ( ( -LRB- 10_1101-2020_03_27_012757 433 52 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 433 53 ) ) -RRB- 10_1101-2020_03_27_012757 433 54 . . . 10_1101-2020_03_27_012757 434 1 ( ( -LRB- 10_1101-2020_03_27_012757 434 2 D d NN 10_1101-2020_03_27_012757 434 3 ) ) -RRB- 10_1101-2020_03_27_012757 434 4 Mean mean JJ 10_1101-2020_03_27_012757 434 5 and and CC 10_1101-2020_03_27_012757 434 6 standard standard JJ 10_1101-2020_03_27_012757 434 7 deviation deviation NN 10_1101-2020_03_27_012757 434 8 of of IN 10_1101-2020_03_27_012757 434 9 classifiers classifier NNS 10_1101-2020_03_27_012757 434 10 based base VBD 10_1101-2020_03_27_012757 434 11 848 848 CD 10_1101-2020_03_27_012757 434 12 on on IN 10_1101-2020_03_27_012757 434 13 50 50 CD 10_1101-2020_03_27_012757 434 14 cross cross NN 10_1101-2020_03_27_012757 434 15 - - NNS 10_1101-2020_03_27_012757 434 16 validations validation NNS 10_1101-2020_03_27_012757 434 17 with with IN 10_1101-2020_03_27_012757 434 18 the the DT 10_1101-2020_03_27_012757 434 19 optimal optimal JJ 10_1101-2020_03_27_012757 434 20 parameter parameter NN 10_1101-2020_03_27_012757 434 21 set set NN 10_1101-2020_03_27_012757 434 22 . . . 10_1101-2020_03_27_012757 435 1 ( ( -LRB- 10_1101-2020_03_27_012757 435 2 E e NN 10_1101-2020_03_27_012757 435 3 ) ) -RRB- 10_1101-2020_03_27_012757 435 4 AUPRC AUPRC NNS 10_1101-2020_03_27_012757 435 5 of of IN 10_1101-2020_03_27_012757 435 6 the the DT 10_1101-2020_03_27_012757 435 7 final final JJ 10_1101-2020_03_27_012757 435 8 CCN CCN NNP 10_1101-2020_03_27_012757 435 9 classifier classifier NN 10_1101-2020_03_27_012757 435 10 849 849 CD 10_1101-2020_03_27_012757 435 11 when when WRB 10_1101-2020_03_27_012757 435 12 applied apply VBN 10_1101-2020_03_27_012757 435 13 to to IN 10_1101-2020_03_27_012757 435 14 independent independent JJ 10_1101-2020_03_27_012757 435 15 patient patient JJ 10_1101-2020_03_27_012757 435 16 tumor tumor NN 10_1101-2020_03_27_012757 435 17 data datum NNS 10_1101-2020_03_27_012757 435 18 from from IN 10_1101-2020_03_27_012757 435 19 ICGC ICGC NNP 10_1101-2020_03_27_012757 435 20 . . . 10_1101-2020_03_27_012757 436 1 850 850 CD 10_1101-2020_03_27_012757 436 2 851 851 CD 10_1101-2020_03_27_012757 436 3 .CC .cc SYM 10_1101-2020_03_27_012757 436 4 - - HYPH 10_1101-2020_03_27_012757 436 5 BY by IN 10_1101-2020_03_27_012757 436 6 - - HYPH 10_1101-2020_03_27_012757 436 7 NC NC NNP 10_1101-2020_03_27_012757 436 8 - - HYPH 10_1101-2020_03_27_012757 436 9 ND ND NNP 10_1101-2020_03_27_012757 436 10 4.0 4.0 CD 10_1101-2020_03_27_012757 436 11 International International NNP 10_1101-2020_03_27_012757 436 12 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 436 13 under under IN 10_1101-2020_03_27_012757 436 14 a a DT 10_1101-2020_03_27_012757 436 15 ( ( -LRB- 10_1101-2020_03_27_012757 436 16 which which WDT 10_1101-2020_03_27_012757 436 17 was be VBD 10_1101-2020_03_27_012757 436 18 not not RB 10_1101-2020_03_27_012757 436 19 certified certify VBN 10_1101-2020_03_27_012757 436 20 by by IN 10_1101-2020_03_27_012757 436 21 peer peer NN 10_1101-2020_03_27_012757 436 22 review review NN 10_1101-2020_03_27_012757 436 23 ) ) -RRB- 10_1101-2020_03_27_012757 436 24 is be VBZ 10_1101-2020_03_27_012757 436 25 the the DT 10_1101-2020_03_27_012757 436 26 author author NN 10_1101-2020_03_27_012757 436 27 / / SYM 10_1101-2020_03_27_012757 436 28 funder funder NN 10_1101-2020_03_27_012757 436 29 , , , 10_1101-2020_03_27_012757 436 30 who who WP 10_1101-2020_03_27_012757 436 31 has have VBZ 10_1101-2020_03_27_012757 436 32 granted grant VBN 10_1101-2020_03_27_012757 436 33 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 436 34 a a DT 10_1101-2020_03_27_012757 436 35 license license NN 10_1101-2020_03_27_012757 436 36 to to TO 10_1101-2020_03_27_012757 436 37 display display VB 10_1101-2020_03_27_012757 436 38 the the DT 10_1101-2020_03_27_012757 436 39 preprint preprint NN 10_1101-2020_03_27_012757 436 40 in in IN 10_1101-2020_03_27_012757 436 41 perpetuity perpetuity NN 10_1101-2020_03_27_012757 436 42 . . . 10_1101-2020_03_27_012757 437 1 It -PRON- PRP 10_1101-2020_03_27_012757 437 2 is be VBZ 10_1101-2020_03_27_012757 437 3 made make VBN 10_1101-2020_03_27_012757 437 4 The the DT 10_1101-2020_03_27_012757 437 5 copyright copyright NN 10_1101-2020_03_27_012757 437 6 holder holder NN 10_1101-2020_03_27_012757 437 7 for for IN 10_1101-2020_03_27_012757 437 8 this this DT 10_1101-2020_03_27_012757 437 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 437 10 version version NN 10_1101-2020_03_27_012757 437 11 posted post VBD 10_1101-2020_03_27_012757 437 12 January January NNP 10_1101-2020_03_27_012757 437 13 9 9 CD 10_1101-2020_03_27_012757 437 14 , , , 10_1101-2020_03_27_012757 437 15 2021 2021 CD 10_1101-2020_03_27_012757 437 16 . . . 10_1101-2020_03_27_012757 437 17 ; ; : 10_1101-2020_03_27_012757 437 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 437 19 : : : 10_1101-2020_03_27_012757 437 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 437 21 preprint preprint NN 10_1101-2020_03_27_012757 437 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 437 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 437 24 33 33 CD 10_1101-2020_03_27_012757 437 25 Fig fig NN 10_1101-2020_03_27_012757 437 26 . . . 10_1101-2020_03_27_012757 438 1 2 2 CD 10_1101-2020_03_27_012757 438 2 Evaluation evaluation NN 10_1101-2020_03_27_012757 438 3 of of IN 10_1101-2020_03_27_012757 438 4 cancer cancer NN 10_1101-2020_03_27_012757 438 5 cell cell NN 10_1101-2020_03_27_012757 438 6 lines line NNS 10_1101-2020_03_27_012757 438 7 . . . 10_1101-2020_03_27_012757 439 1 ( ( -LRB- 10_1101-2020_03_27_012757 439 2 A a DT 10_1101-2020_03_27_012757 439 3 ) ) -RRB- 10_1101-2020_03_27_012757 439 4 General general JJ 10_1101-2020_03_27_012757 439 5 classification classification NN 10_1101-2020_03_27_012757 439 6 heatmap heatmap NN 10_1101-2020_03_27_012757 439 7 of of IN 10_1101-2020_03_27_012757 439 8 CCLs CCLs NNPS 10_1101-2020_03_27_012757 439 9 extracted extract VBD 10_1101-2020_03_27_012757 439 10 852 852 CD 10_1101-2020_03_27_012757 439 11 from from IN 10_1101-2020_03_27_012757 439 12 CCLE CCLE NNP 10_1101-2020_03_27_012757 439 13 . . . 10_1101-2020_03_27_012757 440 1 Column column NN 10_1101-2020_03_27_012757 440 2 annotations annotation NNS 10_1101-2020_03_27_012757 440 3 of of IN 10_1101-2020_03_27_012757 440 4 the the DT 10_1101-2020_03_27_012757 440 5 heatmap heatmap NNP 10_1101-2020_03_27_012757 440 6 represent represent VBP 10_1101-2020_03_27_012757 440 7 the the DT 10_1101-2020_03_27_012757 440 8 labelled label VBN 10_1101-2020_03_27_012757 440 9 cancer cancer NN 10_1101-2020_03_27_012757 440 10 category category NN 10_1101-2020_03_27_012757 440 11 of of IN 10_1101-2020_03_27_012757 440 12 the the DT 10_1101-2020_03_27_012757 440 13 853 853 CD 10_1101-2020_03_27_012757 440 14 CCLs ccl NNS 10_1101-2020_03_27_012757 440 15 given give VBN 10_1101-2020_03_27_012757 440 16 by by IN 10_1101-2020_03_27_012757 440 17 CCLE ccle NN 10_1101-2020_03_27_012757 440 18 and and CC 10_1101-2020_03_27_012757 440 19 the the DT 10_1101-2020_03_27_012757 440 20 row row NN 10_1101-2020_03_27_012757 440 21 names name NNS 10_1101-2020_03_27_012757 440 22 of of IN 10_1101-2020_03_27_012757 440 23 the the DT 10_1101-2020_03_27_012757 440 24 heatmap heatmap NNP 10_1101-2020_03_27_012757 440 25 represent represent VBP 10_1101-2020_03_27_012757 440 26 different different JJ 10_1101-2020_03_27_012757 440 27 cancer cancer NN 10_1101-2020_03_27_012757 440 28 categories category NNS 10_1101-2020_03_27_012757 440 29 . . . 10_1101-2020_03_27_012757 441 1 854 854 CD 10_1101-2020_03_27_012757 441 2 CCLs CCLs NNPS 10_1101-2020_03_27_012757 441 3 ’ ’ POS 10_1101-2020_03_27_012757 441 4 general general JJ 10_1101-2020_03_27_012757 441 5 classification classification NN 10_1101-2020_03_27_012757 441 6 profiles profile NNS 10_1101-2020_03_27_012757 441 7 are be VBP 10_1101-2020_03_27_012757 441 8 categorized categorize VBN 10_1101-2020_03_27_012757 441 9 into into IN 10_1101-2020_03_27_012757 441 10 4 4 CD 10_1101-2020_03_27_012757 441 11 categories category NNS 10_1101-2020_03_27_012757 441 12 : : : 10_1101-2020_03_27_012757 441 13 correct correct JJ 10_1101-2020_03_27_012757 441 14 ( ( -LRB- 10_1101-2020_03_27_012757 441 15 red red NNP 10_1101-2020_03_27_012757 441 16 ) ) -RRB- 10_1101-2020_03_27_012757 441 17 , , , 10_1101-2020_03_27_012757 441 18 correct correct VB 10_1101-2020_03_27_012757 441 19 855 855 CD 10_1101-2020_03_27_012757 441 20 mixed mixed JJ 10_1101-2020_03_27_012757 441 21 ( ( -LRB- 10_1101-2020_03_27_012757 441 22 pink pink JJ 10_1101-2020_03_27_012757 441 23 ) ) -RRB- 10_1101-2020_03_27_012757 441 24 , , , 10_1101-2020_03_27_012757 441 25 no no DT 10_1101-2020_03_27_012757 441 26 classification classification NN 10_1101-2020_03_27_012757 441 27 ( ( -LRB- 10_1101-2020_03_27_012757 441 28 light light JJ 10_1101-2020_03_27_012757 441 29 green green NN 10_1101-2020_03_27_012757 441 30 ) ) -RRB- 10_1101-2020_03_27_012757 441 31 and and CC 10_1101-2020_03_27_012757 441 32 other other JJ 10_1101-2020_03_27_012757 441 33 classification classification NN 10_1101-2020_03_27_012757 441 34 ( ( -LRB- 10_1101-2020_03_27_012757 441 35 dark dark JJ 10_1101-2020_03_27_012757 441 36 green green NN 10_1101-2020_03_27_012757 441 37 ) ) -RRB- 10_1101-2020_03_27_012757 441 38 based base VBN 10_1101-2020_03_27_012757 441 39 on on IN 10_1101-2020_03_27_012757 441 40 the the DT 10_1101-2020_03_27_012757 441 41 856 856 CD 10_1101-2020_03_27_012757 441 42 decision decision NN 10_1101-2020_03_27_012757 441 43 threshold threshold NN 10_1101-2020_03_27_012757 441 44 of of IN 10_1101-2020_03_27_012757 441 45 0.25 0.25 CD 10_1101-2020_03_27_012757 441 46 . . . 10_1101-2020_03_27_012757 442 1 ( ( -LRB- 10_1101-2020_03_27_012757 442 2 B b NN 10_1101-2020_03_27_012757 442 3 ) ) -RRB- 10_1101-2020_03_27_012757 442 4 Bar bar VB 10_1101-2020_03_27_012757 442 5 plot plot NN 10_1101-2020_03_27_012757 442 6 represents represent VBZ 10_1101-2020_03_27_012757 442 7 the the DT 10_1101-2020_03_27_012757 442 8 proportion proportion NN 10_1101-2020_03_27_012757 442 9 of of IN 10_1101-2020_03_27_012757 442 10 each each DT 10_1101-2020_03_27_012757 442 11 classification classification NN 10_1101-2020_03_27_012757 442 12 category category NN 10_1101-2020_03_27_012757 442 13 857 857 CD 10_1101-2020_03_27_012757 442 14 in in IN 10_1101-2020_03_27_012757 442 15 CCLs ccl NNS 10_1101-2020_03_27_012757 442 16 across across IN 10_1101-2020_03_27_012757 442 17 cancer cancer NN 10_1101-2020_03_27_012757 442 18 types type NNS 10_1101-2020_03_27_012757 442 19 ordered order VBN 10_1101-2020_03_27_012757 442 20 from from IN 10_1101-2020_03_27_012757 442 21 the the DT 10_1101-2020_03_27_012757 442 22 cancer cancer NN 10_1101-2020_03_27_012757 442 23 types type NNS 10_1101-2020_03_27_012757 442 24 with with IN 10_1101-2020_03_27_012757 442 25 the the DT 10_1101-2020_03_27_012757 442 26 highest high JJS 10_1101-2020_03_27_012757 442 27 proportion proportion NN 10_1101-2020_03_27_012757 442 28 of of IN 10_1101-2020_03_27_012757 442 29 858 858 CD 10_1101-2020_03_27_012757 442 30 correct correct JJ 10_1101-2020_03_27_012757 442 31 and and CC 10_1101-2020_03_27_012757 442 32 correct correct JJ 10_1101-2020_03_27_012757 442 33 mixed mixed JJ 10_1101-2020_03_27_012757 442 34 CCLs ccl NNS 10_1101-2020_03_27_012757 442 35 to to IN 10_1101-2020_03_27_012757 442 36 lowest low JJS 10_1101-2020_03_27_012757 442 37 proportion proportion NN 10_1101-2020_03_27_012757 442 38 . . . 10_1101-2020_03_27_012757 443 1 ( ( -LRB- 10_1101-2020_03_27_012757 443 2 C C NNP 10_1101-2020_03_27_012757 443 3 ) ) -RRB- 10_1101-2020_03_27_012757 443 4 Comparison comparison NN 10_1101-2020_03_27_012757 443 5 between between IN 10_1101-2020_03_27_012757 443 6 SKCM SKCM NNP 10_1101-2020_03_27_012757 443 7 general general JJ 10_1101-2020_03_27_012757 443 8 859 859 CD 10_1101-2020_03_27_012757 443 9 CCN ccn NN 10_1101-2020_03_27_012757 443 10 scores score NNS 10_1101-2020_03_27_012757 443 11 from from IN 10_1101-2020_03_27_012757 443 12 bulk bulk JJ 10_1101-2020_03_27_012757 443 13 RNA RNA NNP 10_1101-2020_03_27_012757 443 14 - - HYPH 10_1101-2020_03_27_012757 443 15 seq seq NN 10_1101-2020_03_27_012757 443 16 classifier classifier NN 10_1101-2020_03_27_012757 443 17 and and CC 10_1101-2020_03_27_012757 443 18 SKCM skcm VB 10_1101-2020_03_27_012757 443 19 malignant malignant JJ 10_1101-2020_03_27_012757 443 20 CCN CCN NNP 10_1101-2020_03_27_012757 443 21 scores score NNS 10_1101-2020_03_27_012757 443 22 from from IN 10_1101-2020_03_27_012757 443 23 scRNA scRNA NNP 10_1101-2020_03_27_012757 443 24 - - HYPH 10_1101-2020_03_27_012757 443 25 seq seq NN 10_1101-2020_03_27_012757 443 26 860 860 CD 10_1101-2020_03_27_012757 443 27 classifier classifier NN 10_1101-2020_03_27_012757 443 28 for for IN 10_1101-2020_03_27_012757 443 29 SKCM SKCM NNP 10_1101-2020_03_27_012757 443 30 CCLs CCLs NNPS 10_1101-2020_03_27_012757 443 31 . . . 10_1101-2020_03_27_012757 444 1 ( ( -LRB- 10_1101-2020_03_27_012757 444 2 D d NN 10_1101-2020_03_27_012757 444 3 ) ) -RRB- 10_1101-2020_03_27_012757 444 4 Comparison comparison NN 10_1101-2020_03_27_012757 444 5 between between IN 10_1101-2020_03_27_012757 444 6 SARC SARC NNP 10_1101-2020_03_27_012757 444 7 general general JJ 10_1101-2020_03_27_012757 444 8 CCN CCN NNP 10_1101-2020_03_27_012757 444 9 scores score NNS 10_1101-2020_03_27_012757 444 10 from from IN 10_1101-2020_03_27_012757 444 11 bulk bulk NNP 10_1101-2020_03_27_012757 444 12 RNA-861 RNA-861 NNP 10_1101-2020_03_27_012757 444 13 seq seq NN 10_1101-2020_03_27_012757 444 14 classifier classifier NN 10_1101-2020_03_27_012757 444 15 and and CC 10_1101-2020_03_27_012757 444 16 CAF CAF NNP 10_1101-2020_03_27_012757 444 17 CCN CCN NNP 10_1101-2020_03_27_012757 444 18 scores score NNS 10_1101-2020_03_27_012757 444 19 from from IN 10_1101-2020_03_27_012757 444 20 scRNA scrna CD 10_1101-2020_03_27_012757 444 21 - - HYPH 10_1101-2020_03_27_012757 444 22 seq seq NN 10_1101-2020_03_27_012757 444 23 classifier classifier NN 10_1101-2020_03_27_012757 444 24 for for IN 10_1101-2020_03_27_012757 444 25 SKCM SKCM NNP 10_1101-2020_03_27_012757 444 26 CCLs CCLs NNPS 10_1101-2020_03_27_012757 444 27 . . . 10_1101-2020_03_27_012757 445 1 ( ( -LRB- 10_1101-2020_03_27_012757 445 2 E e NN 10_1101-2020_03_27_012757 445 3 ) ) -RRB- 10_1101-2020_03_27_012757 445 4 Comparison comparison NN 10_1101-2020_03_27_012757 445 5 862 862 CD 10_1101-2020_03_27_012757 445 6 between between IN 10_1101-2020_03_27_012757 445 7 GBM GBM NNP 10_1101-2020_03_27_012757 445 8 general general JJ 10_1101-2020_03_27_012757 445 9 CCN CCN NNP 10_1101-2020_03_27_012757 445 10 scores score NNS 10_1101-2020_03_27_012757 445 11 from from IN 10_1101-2020_03_27_012757 445 12 bulk bulk JJ 10_1101-2020_03_27_012757 445 13 RNA RNA NNP 10_1101-2020_03_27_012757 445 14 - - HYPH 10_1101-2020_03_27_012757 445 15 seq seq NN 10_1101-2020_03_27_012757 445 16 classifier classifier NN 10_1101-2020_03_27_012757 445 17 and and CC 10_1101-2020_03_27_012757 445 18 GBM GBM NNP 10_1101-2020_03_27_012757 445 19 neoplastic neoplastic JJ 10_1101-2020_03_27_012757 445 20 CCN CCN NNP 10_1101-2020_03_27_012757 445 21 863 863 CD 10_1101-2020_03_27_012757 445 22 scores score NNS 10_1101-2020_03_27_012757 445 23 from from IN 10_1101-2020_03_27_012757 445 24 scRNA scRNA NNP 10_1101-2020_03_27_012757 445 25 - - HYPH 10_1101-2020_03_27_012757 445 26 seq seq NN 10_1101-2020_03_27_012757 445 27 classifier classifier NN 10_1101-2020_03_27_012757 445 28 for for IN 10_1101-2020_03_27_012757 445 29 GBM GBM NNP 10_1101-2020_03_27_012757 445 30 CCLs CCLs NNPS 10_1101-2020_03_27_012757 445 31 . . . 10_1101-2020_03_27_012757 446 1 ( ( -LRB- 10_1101-2020_03_27_012757 446 2 F F NNP 10_1101-2020_03_27_012757 446 3 ) ) -RRB- 10_1101-2020_03_27_012757 446 4 Comparison comparison NN 10_1101-2020_03_27_012757 446 5 between between IN 10_1101-2020_03_27_012757 446 6 SARC SARC NNP 10_1101-2020_03_27_012757 446 7 general general NN 10_1101-2020_03_27_012757 446 8 CCN CCN NNP 10_1101-2020_03_27_012757 446 9 864 864 CD 10_1101-2020_03_27_012757 446 10 scores score NNS 10_1101-2020_03_27_012757 446 11 and and CC 10_1101-2020_03_27_012757 446 12 CAF CAF NNP 10_1101-2020_03_27_012757 446 13 CCN CCN NNP 10_1101-2020_03_27_012757 446 14 scores score NNS 10_1101-2020_03_27_012757 446 15 from from IN 10_1101-2020_03_27_012757 446 16 scRNA scrna CD 10_1101-2020_03_27_012757 446 17 - - HYPH 10_1101-2020_03_27_012757 446 18 seq seq NN 10_1101-2020_03_27_012757 446 19 classifier classifier NN 10_1101-2020_03_27_012757 446 20 for for IN 10_1101-2020_03_27_012757 446 21 GBM GBM NNP 10_1101-2020_03_27_012757 446 22 CCLs CCLs NNPS 10_1101-2020_03_27_012757 446 23 . . . 10_1101-2020_03_27_012757 447 1 The the DT 10_1101-2020_03_27_012757 447 2 green green JJ 10_1101-2020_03_27_012757 447 3 lines line NNS 10_1101-2020_03_27_012757 447 4 865 865 CD 10_1101-2020_03_27_012757 447 5 indicate indicate VBP 10_1101-2020_03_27_012757 447 6 the the DT 10_1101-2020_03_27_012757 447 7 decision decision NN 10_1101-2020_03_27_012757 447 8 threshold threshold NN 10_1101-2020_03_27_012757 447 9 for for IN 10_1101-2020_03_27_012757 447 10 scRNA scRNA NNP 10_1101-2020_03_27_012757 447 11 - - HYPH 10_1101-2020_03_27_012757 447 12 seq seq NN 10_1101-2020_03_27_012757 447 13 classifier classifier NN 10_1101-2020_03_27_012757 447 14 and and CC 10_1101-2020_03_27_012757 447 15 general general JJ 10_1101-2020_03_27_012757 447 16 classifier classifier NNP 10_1101-2020_03_27_012757 447 17 . . . 10_1101-2020_03_27_012757 448 1 866 866 CD 10_1101-2020_03_27_012757 448 2 867 867 CD 10_1101-2020_03_27_012757 448 3 Fig Fig NNP 10_1101-2020_03_27_012757 448 4 . . . 10_1101-2020_03_27_012757 449 1 3 3 CD 10_1101-2020_03_27_012757 449 2 Immunofluorescence Immunofluorescence NNP 10_1101-2020_03_27_012757 449 3 of of IN 10_1101-2020_03_27_012757 449 4 selected select VBN 10_1101-2020_03_27_012757 449 5 cell cell NN 10_1101-2020_03_27_012757 449 6 lines line NNS 10_1101-2020_03_27_012757 449 7 . . . 10_1101-2020_03_27_012757 450 1 ( ( -LRB- 10_1101-2020_03_27_012757 450 2 A a NN 10_1101-2020_03_27_012757 450 3 ) ) -RRB- 10_1101-2020_03_27_012757 450 4 Classification classification NN 10_1101-2020_03_27_012757 450 5 profiles profile NNS 10_1101-2020_03_27_012757 450 6 ( ( -LRB- 10_1101-2020_03_27_012757 450 7 left left RB 10_1101-2020_03_27_012757 450 8 ) ) -RRB- 10_1101-2020_03_27_012757 450 9 and and CC 10_1101-2020_03_27_012757 450 10 IF if IN 10_1101-2020_03_27_012757 450 11 868 868 CD 10_1101-2020_03_27_012757 450 12 expression expression NN 10_1101-2020_03_27_012757 450 13 ( ( -LRB- 10_1101-2020_03_27_012757 450 14 middle middle JJ 10_1101-2020_03_27_012757 450 15 ) ) -RRB- 10_1101-2020_03_27_012757 450 16 of of IN 10_1101-2020_03_27_012757 450 17 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 450 18 ( ( -LRB- 10_1101-2020_03_27_012757 450 19 OV OV NNP 10_1101-2020_03_27_012757 450 20 positive positive JJ 10_1101-2020_03_27_012757 450 21 control control NN 10_1101-2020_03_27_012757 450 22 ) ) -RRB- 10_1101-2020_03_27_012757 450 23 , , , 10_1101-2020_03_27_012757 450 24 HEC-59 HEC-59 NNP 10_1101-2020_03_27_012757 450 25 ( ( -LRB- 10_1101-2020_03_27_012757 450 26 UCEC UCEC NNP 10_1101-2020_03_27_012757 450 27 positive positive JJ 10_1101-2020_03_27_012757 450 28 control control NN 10_1101-2020_03_27_012757 450 29 ) ) -RRB- 10_1101-2020_03_27_012757 450 30 and and CC 10_1101-2020_03_27_012757 450 31 SK-869 SK-869 NNP 10_1101-2020_03_27_012757 450 32 OV-3 OV-3 NNP 10_1101-2020_03_27_012757 450 33 for for IN 10_1101-2020_03_27_012757 450 34 WT1 WT1 NNP 10_1101-2020_03_27_012757 450 35 ( ( -LRB- 10_1101-2020_03_27_012757 450 36 OV OV NNP 10_1101-2020_03_27_012757 450 37 biomarker biomarker NN 10_1101-2020_03_27_012757 450 38 ) ) -RRB- 10_1101-2020_03_27_012757 450 39 and and CC 10_1101-2020_03_27_012757 450 40 HOXB6 HOXB6 NNS 10_1101-2020_03_27_012757 450 41 ( ( -LRB- 10_1101-2020_03_27_012757 450 42 uterine uterine NNP 10_1101-2020_03_27_012757 450 43 biomarker biomarker NN 10_1101-2020_03_27_012757 450 44 ) ) -RRB- 10_1101-2020_03_27_012757 450 45 . . . 10_1101-2020_03_27_012757 451 1 The the DT 10_1101-2020_03_27_012757 451 2 bar bar NN 10_1101-2020_03_27_012757 451 3 plots plot NNS 10_1101-2020_03_27_012757 451 4 quantify quantify VBP 10_1101-2020_03_27_012757 451 5 the the DT 10_1101-2020_03_27_012757 451 6 870 870 CD 10_1101-2020_03_27_012757 451 7 average average JJ 10_1101-2020_03_27_012757 451 8 percentage percentage NN 10_1101-2020_03_27_012757 451 9 of of IN 10_1101-2020_03_27_012757 451 10 positive positive JJ 10_1101-2020_03_27_012757 451 11 cells cell NNS 10_1101-2020_03_27_012757 451 12 for for IN 10_1101-2020_03_27_012757 451 13 WT1 WT1 NNP 10_1101-2020_03_27_012757 451 14 ( ( -LRB- 10_1101-2020_03_27_012757 451 15 top top JJ 10_1101-2020_03_27_012757 451 16 - - HYPH 10_1101-2020_03_27_012757 451 17 right right NN 10_1101-2020_03_27_012757 451 18 ) ) -RRB- 10_1101-2020_03_27_012757 451 19 and and CC 10_1101-2020_03_27_012757 451 20 HOXB6 HOXB6 NNS 10_1101-2020_03_27_012757 451 21 ( ( -LRB- 10_1101-2020_03_27_012757 451 22 bottom bottom JJ 10_1101-2020_03_27_012757 451 23 - - HYPH 10_1101-2020_03_27_012757 451 24 right right JJ 10_1101-2020_03_27_012757 451 25 ) ) -RRB- 10_1101-2020_03_27_012757 451 26 . . . 10_1101-2020_03_27_012757 452 1 ( ( -LRB- 10_1101-2020_03_27_012757 452 2 B b NN 10_1101-2020_03_27_012757 452 3 ) ) -RRB- 10_1101-2020_03_27_012757 452 4 871 871 CD 10_1101-2020_03_27_012757 452 5 Classification classification NN 10_1101-2020_03_27_012757 452 6 profiles profile NNS 10_1101-2020_03_27_012757 452 7 ( ( -LRB- 10_1101-2020_03_27_012757 452 8 left left RB 10_1101-2020_03_27_012757 452 9 ) ) -RRB- 10_1101-2020_03_27_012757 452 10 and and CC 10_1101-2020_03_27_012757 452 11 IF if IN 10_1101-2020_03_27_012757 452 12 expression expression NN 10_1101-2020_03_27_012757 452 13 ( ( -LRB- 10_1101-2020_03_27_012757 452 14 middle middle NN 10_1101-2020_03_27_012757 452 15 ) ) -RRB- 10_1101-2020_03_27_012757 452 16 of of IN 10_1101-2020_03_27_012757 452 17 Caov-4 Caov-4 NNP 10_1101-2020_03_27_012757 452 18 , , , 10_1101-2020_03_27_012757 452 19 NCCIT NCCIT NNP 10_1101-2020_03_27_012757 452 20 ( ( -LRB- 10_1101-2020_03_27_012757 452 21 germ germ NNP 10_1101-2020_03_27_012757 452 22 cell cell NN 10_1101-2020_03_27_012757 452 23 tumor tumor NN 10_1101-2020_03_27_012757 452 24 872 872 CD 10_1101-2020_03_27_012757 452 25 positive positive JJ 10_1101-2020_03_27_012757 452 26 control control NN 10_1101-2020_03_27_012757 452 27 ) ) -RRB- 10_1101-2020_03_27_012757 452 28 and and CC 10_1101-2020_03_27_012757 452 29 A2780 A2780 NNP 10_1101-2020_03_27_012757 452 30 for for IN 10_1101-2020_03_27_012757 452 31 WT1 WT1 NNP 10_1101-2020_03_27_012757 452 32 and and CC 10_1101-2020_03_27_012757 452 33 LIN28A LIN28A NNP 10_1101-2020_03_27_012757 452 34 ( ( -LRB- 10_1101-2020_03_27_012757 452 35 germ germ NNP 10_1101-2020_03_27_012757 452 36 cell cell NN 10_1101-2020_03_27_012757 452 37 tumor tumor NN 10_1101-2020_03_27_012757 452 38 biomarker biomarker NN 10_1101-2020_03_27_012757 452 39 ) ) -RRB- 10_1101-2020_03_27_012757 452 40 . . . 10_1101-2020_03_27_012757 453 1 Classification classification NN 10_1101-2020_03_27_012757 453 2 of of IN 10_1101-2020_03_27_012757 453 3 873 873 CD 10_1101-2020_03_27_012757 453 4 NCCIT NCCIT NNP 10_1101-2020_03_27_012757 453 5 were be VBD 10_1101-2020_03_27_012757 453 6 performed perform VBN 10_1101-2020_03_27_012757 453 7 using use VBG 10_1101-2020_03_27_012757 453 8 RNA RNA NNP 10_1101-2020_03_27_012757 453 9 - - HYPH 10_1101-2020_03_27_012757 453 10 seq seq NN 10_1101-2020_03_27_012757 453 11 profiles profile NNS 10_1101-2020_03_27_012757 453 12 of of IN 10_1101-2020_03_27_012757 453 13 WT WT NNP 10_1101-2020_03_27_012757 453 14 control control NN 10_1101-2020_03_27_012757 453 15 NCCIT NCCIT NNP 10_1101-2020_03_27_012757 453 16 duplicate duplicate VBP 10_1101-2020_03_27_012757 453 17 from from IN 10_1101-2020_03_27_012757 453 18 Grow Grow NNP 10_1101-2020_03_27_012757 453 19 et et NNP 10_1101-2020_03_27_012757 453 20 874 874 CD 10_1101-2020_03_27_012757 453 21 al91 al91 NNP 10_1101-2020_03_27_012757 453 22 . . . 10_1101-2020_03_27_012757 454 1 The the DT 10_1101-2020_03_27_012757 454 2 bar bar NN 10_1101-2020_03_27_012757 454 3 plots plot NNS 10_1101-2020_03_27_012757 454 4 quantify quantify VBP 10_1101-2020_03_27_012757 454 5 the the DT 10_1101-2020_03_27_012757 454 6 average average JJ 10_1101-2020_03_27_012757 454 7 percentage percentage NN 10_1101-2020_03_27_012757 454 8 of of IN 10_1101-2020_03_27_012757 454 9 positive positive JJ 10_1101-2020_03_27_012757 454 10 cells cell NNS 10_1101-2020_03_27_012757 454 11 for for IN 10_1101-2020_03_27_012757 454 12 WT1 WT1 NNP 10_1101-2020_03_27_012757 454 13 ( ( -LRB- 10_1101-2020_03_27_012757 454 14 top top JJ 10_1101-2020_03_27_012757 454 15 - - HYPH 10_1101-2020_03_27_012757 454 16 right right NN 10_1101-2020_03_27_012757 454 17 ) ) -RRB- 10_1101-2020_03_27_012757 454 18 and and CC 10_1101-2020_03_27_012757 454 19 875 875 CD 10_1101-2020_03_27_012757 454 20 LIN28A lin28a CD 10_1101-2020_03_27_012757 454 21 ( ( -LRB- 10_1101-2020_03_27_012757 454 22 bottom bottom NN 10_1101-2020_03_27_012757 454 23 - - HYPH 10_1101-2020_03_27_012757 454 24 right right JJ 10_1101-2020_03_27_012757 454 25 ) ) -RRB- 10_1101-2020_03_27_012757 454 26 . . . 10_1101-2020_03_27_012757 455 1 ( ( -LRB- 10_1101-2020_03_27_012757 455 2 C c NN 10_1101-2020_03_27_012757 455 3 ) ) -RRB- 10_1101-2020_03_27_012757 455 4 Classification classification NN 10_1101-2020_03_27_012757 455 5 profiles profile NNS 10_1101-2020_03_27_012757 455 6 ( ( -LRB- 10_1101-2020_03_27_012757 455 7 left left RB 10_1101-2020_03_27_012757 455 8 ) ) -RRB- 10_1101-2020_03_27_012757 455 9 and and CC 10_1101-2020_03_27_012757 455 10 IF if IN 10_1101-2020_03_27_012757 455 11 expression expression NN 10_1101-2020_03_27_012757 455 12 ( ( -LRB- 10_1101-2020_03_27_012757 455 13 middle middle JJ 10_1101-2020_03_27_012757 455 14 ) ) -RRB- 10_1101-2020_03_27_012757 455 15 of of IN 10_1101-2020_03_27_012757 455 16 Vcap Vcap NNP 10_1101-2020_03_27_012757 455 17 876 876 CD 10_1101-2020_03_27_012757 455 18 ( ( -LRB- 10_1101-2020_03_27_012757 455 19 PRAD PRAD NNP 10_1101-2020_03_27_012757 455 20 positive positive JJ 10_1101-2020_03_27_012757 455 21 control control NN 10_1101-2020_03_27_012757 455 22 ) ) -RRB- 10_1101-2020_03_27_012757 455 23 , , , 10_1101-2020_03_27_012757 455 24 RT4 RT4 NNP 10_1101-2020_03_27_012757 455 25 ( ( -LRB- 10_1101-2020_03_27_012757 455 26 BLCA BLCA NNP 10_1101-2020_03_27_012757 455 27 positive positive JJ 10_1101-2020_03_27_012757 455 28 control control NN 10_1101-2020_03_27_012757 455 29 ) ) -RRB- 10_1101-2020_03_27_012757 455 30 and and CC 10_1101-2020_03_27_012757 455 31 PC-3 PC-3 NNP 10_1101-2020_03_27_012757 455 32 for for IN 10_1101-2020_03_27_012757 455 33 FOLH1 FOLH1 NNP 10_1101-2020_03_27_012757 455 34 ( ( -LRB- 10_1101-2020_03_27_012757 455 35 prostate prostate NN 10_1101-2020_03_27_012757 455 36 biomarker biomarker NNP 10_1101-2020_03_27_012757 455 37 ) ) -RRB- 10_1101-2020_03_27_012757 455 38 877 877 CD 10_1101-2020_03_27_012757 455 39 .CC .CC , 10_1101-2020_03_27_012757 455 40 - - HYPH 10_1101-2020_03_27_012757 455 41 BY by IN 10_1101-2020_03_27_012757 455 42 - - HYPH 10_1101-2020_03_27_012757 455 43 NC NC NNP 10_1101-2020_03_27_012757 455 44 - - HYPH 10_1101-2020_03_27_012757 455 45 ND ND NNP 10_1101-2020_03_27_012757 455 46 4.0 4.0 CD 10_1101-2020_03_27_012757 455 47 International International NNP 10_1101-2020_03_27_012757 455 48 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 455 49 under under IN 10_1101-2020_03_27_012757 455 50 a a DT 10_1101-2020_03_27_012757 455 51 ( ( -LRB- 10_1101-2020_03_27_012757 455 52 which which WDT 10_1101-2020_03_27_012757 455 53 was be VBD 10_1101-2020_03_27_012757 455 54 not not RB 10_1101-2020_03_27_012757 455 55 certified certify VBN 10_1101-2020_03_27_012757 455 56 by by IN 10_1101-2020_03_27_012757 455 57 peer peer NN 10_1101-2020_03_27_012757 455 58 review review NN 10_1101-2020_03_27_012757 455 59 ) ) -RRB- 10_1101-2020_03_27_012757 455 60 is be VBZ 10_1101-2020_03_27_012757 455 61 the the DT 10_1101-2020_03_27_012757 455 62 author author NN 10_1101-2020_03_27_012757 455 63 / / SYM 10_1101-2020_03_27_012757 455 64 funder funder NN 10_1101-2020_03_27_012757 455 65 , , , 10_1101-2020_03_27_012757 455 66 who who WP 10_1101-2020_03_27_012757 455 67 has have VBZ 10_1101-2020_03_27_012757 455 68 granted grant VBN 10_1101-2020_03_27_012757 455 69 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 455 70 a a DT 10_1101-2020_03_27_012757 455 71 license license NN 10_1101-2020_03_27_012757 455 72 to to TO 10_1101-2020_03_27_012757 455 73 display display VB 10_1101-2020_03_27_012757 455 74 the the DT 10_1101-2020_03_27_012757 455 75 preprint preprint NN 10_1101-2020_03_27_012757 455 76 in in IN 10_1101-2020_03_27_012757 455 77 perpetuity perpetuity NN 10_1101-2020_03_27_012757 455 78 . . . 10_1101-2020_03_27_012757 456 1 It -PRON- PRP 10_1101-2020_03_27_012757 456 2 is be VBZ 10_1101-2020_03_27_012757 456 3 made make VBN 10_1101-2020_03_27_012757 456 4 The the DT 10_1101-2020_03_27_012757 456 5 copyright copyright NN 10_1101-2020_03_27_012757 456 6 holder holder NN 10_1101-2020_03_27_012757 456 7 for for IN 10_1101-2020_03_27_012757 456 8 this this DT 10_1101-2020_03_27_012757 456 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 456 10 version version NN 10_1101-2020_03_27_012757 456 11 posted post VBD 10_1101-2020_03_27_012757 456 12 January January NNP 10_1101-2020_03_27_012757 456 13 9 9 CD 10_1101-2020_03_27_012757 456 14 , , , 10_1101-2020_03_27_012757 456 15 2021 2021 CD 10_1101-2020_03_27_012757 456 16 . . . 10_1101-2020_03_27_012757 456 17 ; ; : 10_1101-2020_03_27_012757 456 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 456 19 : : : 10_1101-2020_03_27_012757 456 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 456 21 preprint preprint NN 10_1101-2020_03_27_012757 456 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 456 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 456 24 34 34 CD 10_1101-2020_03_27_012757 456 25 and and CC 10_1101-2020_03_27_012757 456 26 PPARG PPARG NNP 10_1101-2020_03_27_012757 456 27 ( ( -LRB- 10_1101-2020_03_27_012757 456 28 urothelial urothelial JJ 10_1101-2020_03_27_012757 456 29 biomarker biomarker NN 10_1101-2020_03_27_012757 456 30 ) ) -RRB- 10_1101-2020_03_27_012757 456 31 . . . 10_1101-2020_03_27_012757 457 1 The the DT 10_1101-2020_03_27_012757 457 2 bar bar NN 10_1101-2020_03_27_012757 457 3 plots plot NNS 10_1101-2020_03_27_012757 457 4 quantify quantify VBP 10_1101-2020_03_27_012757 457 5 the the DT 10_1101-2020_03_27_012757 457 6 average average JJ 10_1101-2020_03_27_012757 457 7 percentage percentage NN 10_1101-2020_03_27_012757 457 8 of of IN 10_1101-2020_03_27_012757 457 9 positive positive JJ 10_1101-2020_03_27_012757 457 10 878 878 CD 10_1101-2020_03_27_012757 457 11 cells cell NNS 10_1101-2020_03_27_012757 457 12 for for IN 10_1101-2020_03_27_012757 457 13 FOLH1 FOLH1 NNS 10_1101-2020_03_27_012757 457 14 ( ( -LRB- 10_1101-2020_03_27_012757 457 15 top top JJ 10_1101-2020_03_27_012757 457 16 - - HYPH 10_1101-2020_03_27_012757 457 17 right right NN 10_1101-2020_03_27_012757 457 18 ) ) -RRB- 10_1101-2020_03_27_012757 457 19 and and CC 10_1101-2020_03_27_012757 457 20 PPARG PPARG NNP 10_1101-2020_03_27_012757 457 21 ( ( -LRB- 10_1101-2020_03_27_012757 457 22 bottom bottom JJ 10_1101-2020_03_27_012757 457 23 - - HYPH 10_1101-2020_03_27_012757 457 24 right right JJ 10_1101-2020_03_27_012757 457 25 ) ) -RRB- 10_1101-2020_03_27_012757 457 26 . . . 10_1101-2020_03_27_012757 458 1 879 879 CD 10_1101-2020_03_27_012757 458 2 880 880 CD 10_1101-2020_03_27_012757 458 3 Fig fig NN 10_1101-2020_03_27_012757 458 4 . . . 10_1101-2020_03_27_012757 459 1 4 4 CD 10_1101-2020_03_27_012757 459 2 Subtype subtype NN 10_1101-2020_03_27_012757 459 3 classification classification NN 10_1101-2020_03_27_012757 459 4 of of IN 10_1101-2020_03_27_012757 459 5 CCLs CCLs NNP 10_1101-2020_03_27_012757 459 6 and and CC 10_1101-2020_03_27_012757 459 7 CCL CCL NNP 10_1101-2020_03_27_012757 459 8 prevalence prevalence NN 10_1101-2020_03_27_012757 459 9 . . . 10_1101-2020_03_27_012757 460 1 The the DT 10_1101-2020_03_27_012757 460 2 heatmap heatmap NNP 10_1101-2020_03_27_012757 460 3 visualizations visualization VBZ 10_1101-2020_03_27_012757 460 4 881 881 CD 10_1101-2020_03_27_012757 460 5 represent represent NN 10_1101-2020_03_27_012757 460 6 subtype subtype NN 10_1101-2020_03_27_012757 460 7 classification classification NN 10_1101-2020_03_27_012757 460 8 of of IN 10_1101-2020_03_27_012757 460 9 ( ( -LRB- 10_1101-2020_03_27_012757 460 10 A a NN 10_1101-2020_03_27_012757 460 11 ) ) -RRB- 10_1101-2020_03_27_012757 460 12 UCEC UCEC NNP 10_1101-2020_03_27_012757 460 13 CCLs ccl NNS 10_1101-2020_03_27_012757 460 14 , , , 10_1101-2020_03_27_012757 460 15 ( ( -LRB- 10_1101-2020_03_27_012757 460 16 B b NN 10_1101-2020_03_27_012757 460 17 ) ) -RRB- 10_1101-2020_03_27_012757 460 18 LUSC LUSC NNP 10_1101-2020_03_27_012757 460 19 CCLs ccl NNS 10_1101-2020_03_27_012757 460 20 and and CC 10_1101-2020_03_27_012757 460 21 ( ( -LRB- 10_1101-2020_03_27_012757 460 22 C C NNP 10_1101-2020_03_27_012757 460 23 ) ) -RRB- 10_1101-2020_03_27_012757 460 24 LUAD luad RB 10_1101-2020_03_27_012757 460 25 CCLs ccl NNS 10_1101-2020_03_27_012757 460 26 . . . 10_1101-2020_03_27_012757 461 1 Only only RB 10_1101-2020_03_27_012757 461 2 882 882 CD 10_1101-2020_03_27_012757 461 3 samples sample NNS 10_1101-2020_03_27_012757 461 4 with with IN 10_1101-2020_03_27_012757 461 5 CCN CCN NNP 10_1101-2020_03_27_012757 461 6 scores score NNS 10_1101-2020_03_27_012757 461 7 > > XX 10_1101-2020_03_27_012757 461 8 0.1 0.1 CD 10_1101-2020_03_27_012757 461 9 in in IN 10_1101-2020_03_27_012757 461 10 their -PRON- PRP$ 10_1101-2020_03_27_012757 461 11 nominal nominal JJ 10_1101-2020_03_27_012757 461 12 tumor tumor NN 10_1101-2020_03_27_012757 461 13 type type NN 10_1101-2020_03_27_012757 461 14 are be VBP 10_1101-2020_03_27_012757 461 15 displayed display VBN 10_1101-2020_03_27_012757 461 16 . . . 10_1101-2020_03_27_012757 462 1 ( ( -LRB- 10_1101-2020_03_27_012757 462 2 D d NN 10_1101-2020_03_27_012757 462 3 ) ) -RRB- 10_1101-2020_03_27_012757 462 4 Comparison comparison NN 10_1101-2020_03_27_012757 462 5 of of IN 10_1101-2020_03_27_012757 462 6 883 883 CD 10_1101-2020_03_27_012757 462 7 normalized normalized JJ 10_1101-2020_03_27_012757 462 8 citation citation NN 10_1101-2020_03_27_012757 462 9 counts count NNS 10_1101-2020_03_27_012757 462 10 and and CC 10_1101-2020_03_27_012757 462 11 general general JJ 10_1101-2020_03_27_012757 462 12 CCN CCN NNP 10_1101-2020_03_27_012757 462 13 classification classification NN 10_1101-2020_03_27_012757 462 14 scores score NNS 10_1101-2020_03_27_012757 462 15 of of IN 10_1101-2020_03_27_012757 462 16 CCLs ccl NNS 10_1101-2020_03_27_012757 462 17 . . . 10_1101-2020_03_27_012757 463 1 Labelled label VBN 10_1101-2020_03_27_012757 463 2 cell cell NN 10_1101-2020_03_27_012757 463 3 lines line NNS 10_1101-2020_03_27_012757 463 4 884 884 CD 10_1101-2020_03_27_012757 463 5 either either CC 10_1101-2020_03_27_012757 463 6 have have VBP 10_1101-2020_03_27_012757 463 7 the the DT 10_1101-2020_03_27_012757 463 8 highest high JJS 10_1101-2020_03_27_012757 463 9 CCN CCN NNP 10_1101-2020_03_27_012757 463 10 classification classification NN 10_1101-2020_03_27_012757 463 11 score score NN 10_1101-2020_03_27_012757 463 12 in in IN 10_1101-2020_03_27_012757 463 13 their -PRON- PRP$ 10_1101-2020_03_27_012757 463 14 labelled label VBN 10_1101-2020_03_27_012757 463 15 cancer cancer NN 10_1101-2020_03_27_012757 463 16 category category NN 10_1101-2020_03_27_012757 463 17 or or CC 10_1101-2020_03_27_012757 463 18 highest high JJS 10_1101-2020_03_27_012757 463 19 885 885 CD 10_1101-2020_03_27_012757 463 20 normalized normalized JJ 10_1101-2020_03_27_012757 463 21 citation citation NN 10_1101-2020_03_27_012757 463 22 count count NN 10_1101-2020_03_27_012757 463 23 . . . 10_1101-2020_03_27_012757 464 1 Each each DT 10_1101-2020_03_27_012757 464 2 citation citation NN 10_1101-2020_03_27_012757 464 3 count count NN 10_1101-2020_03_27_012757 464 4 was be VBD 10_1101-2020_03_27_012757 464 5 normalized normalize VBN 10_1101-2020_03_27_012757 464 6 by by IN 10_1101-2020_03_27_012757 464 7 number number NN 10_1101-2020_03_27_012757 464 8 of of IN 10_1101-2020_03_27_012757 464 9 years year NNS 10_1101-2020_03_27_012757 464 10 since since IN 10_1101-2020_03_27_012757 464 11 first first RB 10_1101-2020_03_27_012757 464 12 886 886 CD 10_1101-2020_03_27_012757 464 13 documented document VBN 10_1101-2020_03_27_012757 464 14 on on IN 10_1101-2020_03_27_012757 464 15 PubMed PubMed NNP 10_1101-2020_03_27_012757 464 16 . . . 10_1101-2020_03_27_012757 465 1 887 887 CD 10_1101-2020_03_27_012757 465 2 888 888 CD 10_1101-2020_03_27_012757 465 3 Fig fig NN 10_1101-2020_03_27_012757 465 4 . . . 10_1101-2020_03_27_012757 466 1 5 5 CD 10_1101-2020_03_27_012757 466 2 Evaluation evaluation NN 10_1101-2020_03_27_012757 466 3 of of IN 10_1101-2020_03_27_012757 466 4 patient patient JJ 10_1101-2020_03_27_012757 466 5 derived derive VBN 10_1101-2020_03_27_012757 466 6 xenografts xenograft NNS 10_1101-2020_03_27_012757 466 7 . . . 10_1101-2020_03_27_012757 467 1 ( ( -LRB- 10_1101-2020_03_27_012757 467 2 A a DT 10_1101-2020_03_27_012757 467 3 ) ) -RRB- 10_1101-2020_03_27_012757 467 4 General General NNP 10_1101-2020_03_27_012757 467 5 classification classification NN 10_1101-2020_03_27_012757 467 6 heatmap heatmap NN 10_1101-2020_03_27_012757 467 7 of of IN 10_1101-2020_03_27_012757 467 8 PDXs PDXs NNP 10_1101-2020_03_27_012757 467 9 . . . 10_1101-2020_03_27_012757 468 1 889 889 CD 10_1101-2020_03_27_012757 468 2 Column column NN 10_1101-2020_03_27_012757 468 3 annotations annotation NNS 10_1101-2020_03_27_012757 468 4 represent represent VBP 10_1101-2020_03_27_012757 468 5 annotated annotate VBN 10_1101-2020_03_27_012757 468 6 cancer cancer NN 10_1101-2020_03_27_012757 468 7 type type NN 10_1101-2020_03_27_012757 468 8 of of IN 10_1101-2020_03_27_012757 468 9 the the DT 10_1101-2020_03_27_012757 468 10 PDXs pdx NNS 10_1101-2020_03_27_012757 468 11 , , , 10_1101-2020_03_27_012757 468 12 and and CC 10_1101-2020_03_27_012757 468 13 row row NN 10_1101-2020_03_27_012757 468 14 names name NNS 10_1101-2020_03_27_012757 468 15 represent represent VBP 10_1101-2020_03_27_012757 468 16 890 890 CD 10_1101-2020_03_27_012757 468 17 cancer cancer NN 10_1101-2020_03_27_012757 468 18 categories category NNS 10_1101-2020_03_27_012757 468 19 . . . 10_1101-2020_03_27_012757 469 1 ( ( -LRB- 10_1101-2020_03_27_012757 469 2 B b NN 10_1101-2020_03_27_012757 469 3 ) ) -RRB- 10_1101-2020_03_27_012757 469 4 Proportion proportion NN 10_1101-2020_03_27_012757 469 5 of of IN 10_1101-2020_03_27_012757 469 6 classification classification NN 10_1101-2020_03_27_012757 469 7 categories category NNS 10_1101-2020_03_27_012757 469 8 in in IN 10_1101-2020_03_27_012757 469 9 PDXs pdx NNS 10_1101-2020_03_27_012757 469 10 across across IN 10_1101-2020_03_27_012757 469 11 cancer cancer NN 10_1101-2020_03_27_012757 469 12 types type NNS 10_1101-2020_03_27_012757 469 13 is be VBZ 10_1101-2020_03_27_012757 469 14 891 891 CD 10_1101-2020_03_27_012757 469 15 visualized visualize VBN 10_1101-2020_03_27_012757 469 16 in in IN 10_1101-2020_03_27_012757 469 17 the the DT 10_1101-2020_03_27_012757 469 18 bar bar NN 10_1101-2020_03_27_012757 469 19 plot plot NN 10_1101-2020_03_27_012757 469 20 and and CC 10_1101-2020_03_27_012757 469 21 ordered order VBN 10_1101-2020_03_27_012757 469 22 from from IN 10_1101-2020_03_27_012757 469 23 the the DT 10_1101-2020_03_27_012757 469 24 cancer cancer NN 10_1101-2020_03_27_012757 469 25 type type NN 10_1101-2020_03_27_012757 469 26 with with IN 10_1101-2020_03_27_012757 469 27 highest high JJS 10_1101-2020_03_27_012757 469 28 proportion proportion NN 10_1101-2020_03_27_012757 469 29 of of IN 10_1101-2020_03_27_012757 469 30 correct correct JJ 10_1101-2020_03_27_012757 469 31 and and CC 10_1101-2020_03_27_012757 469 32 892 892 CD 10_1101-2020_03_27_012757 469 33 mixed mixed JJ 10_1101-2020_03_27_012757 469 34 correct correct JJ 10_1101-2020_03_27_012757 469 35 classified classify VBN 10_1101-2020_03_27_012757 469 36 PDXs pdx NNS 10_1101-2020_03_27_012757 469 37 to to IN 10_1101-2020_03_27_012757 469 38 the the DT 10_1101-2020_03_27_012757 469 39 lowest low JJS 10_1101-2020_03_27_012757 469 40 . . . 10_1101-2020_03_27_012757 470 1 Subtype subtype NN 10_1101-2020_03_27_012757 470 2 classification classification NN 10_1101-2020_03_27_012757 470 3 heatmaps heatmap NNS 10_1101-2020_03_27_012757 470 4 of of IN 10_1101-2020_03_27_012757 470 5 ( ( -LRB- 10_1101-2020_03_27_012757 470 6 C C NNP 10_1101-2020_03_27_012757 470 7 ) ) -RRB- 10_1101-2020_03_27_012757 470 8 UCEC UCEC NNP 10_1101-2020_03_27_012757 470 9 893 893 CD 10_1101-2020_03_27_012757 470 10 PDXs pdx NNS 10_1101-2020_03_27_012757 470 11 , , , 10_1101-2020_03_27_012757 470 12 ( ( -LRB- 10_1101-2020_03_27_012757 470 13 D d NN 10_1101-2020_03_27_012757 470 14 ) ) -RRB- 10_1101-2020_03_27_012757 470 15 LUSC LUSC NNP 10_1101-2020_03_27_012757 470 16 PDXs pdx NNS 10_1101-2020_03_27_012757 470 17 and and CC 10_1101-2020_03_27_012757 470 18 ( ( -LRB- 10_1101-2020_03_27_012757 470 19 E e NN 10_1101-2020_03_27_012757 470 20 ) ) -RRB- 10_1101-2020_03_27_012757 470 21 LUAD luad JJ 10_1101-2020_03_27_012757 470 22 PDXs pdx NNS 10_1101-2020_03_27_012757 470 23 . . . 10_1101-2020_03_27_012757 471 1 Only only RB 10_1101-2020_03_27_012757 471 2 samples sample NNS 10_1101-2020_03_27_012757 471 3 with with IN 10_1101-2020_03_27_012757 471 4 CCN CCN NNP 10_1101-2020_03_27_012757 471 5 scores score NNS 10_1101-2020_03_27_012757 471 6 > > XX 10_1101-2020_03_27_012757 471 7 0.1 0.1 CD 10_1101-2020_03_27_012757 471 8 in in IN 10_1101-2020_03_27_012757 471 9 their -PRON- PRP$ 10_1101-2020_03_27_012757 471 10 894 894 CD 10_1101-2020_03_27_012757 471 11 nominal nominal JJ 10_1101-2020_03_27_012757 471 12 tumor tumor NN 10_1101-2020_03_27_012757 471 13 type type NN 10_1101-2020_03_27_012757 471 14 are be VBP 10_1101-2020_03_27_012757 471 15 displayed display VBN 10_1101-2020_03_27_012757 471 16 . . . 10_1101-2020_03_27_012757 472 1 895 895 CD 10_1101-2020_03_27_012757 472 2 896 896 CD 10_1101-2020_03_27_012757 472 3 Fig fig NN 10_1101-2020_03_27_012757 472 4 . . . 10_1101-2020_03_27_012757 473 1 6 6 CD 10_1101-2020_03_27_012757 473 2 Evaluation Evaluation NNP 10_1101-2020_03_27_012757 473 3 of of IN 10_1101-2020_03_27_012757 473 4 genetically genetically RB 10_1101-2020_03_27_012757 473 5 engineered engineer VBN 10_1101-2020_03_27_012757 473 6 mouse mouse NN 10_1101-2020_03_27_012757 473 7 models model NNS 10_1101-2020_03_27_012757 473 8 . . . 10_1101-2020_03_27_012757 474 1 ( ( -LRB- 10_1101-2020_03_27_012757 474 2 A a DT 10_1101-2020_03_27_012757 474 3 ) ) -RRB- 10_1101-2020_03_27_012757 474 4 General General NNP 10_1101-2020_03_27_012757 474 5 classification classification NN 10_1101-2020_03_27_012757 474 6 897 897 CD 10_1101-2020_03_27_012757 474 7 heatmap heatmap NN 10_1101-2020_03_27_012757 474 8 of of IN 10_1101-2020_03_27_012757 474 9 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 474 10 . . . 10_1101-2020_03_27_012757 475 1 Column column NN 10_1101-2020_03_27_012757 475 2 annotations annotation NNS 10_1101-2020_03_27_012757 475 3 represent represent VBP 10_1101-2020_03_27_012757 475 4 annotated annotate VBN 10_1101-2020_03_27_012757 475 5 cancer cancer NN 10_1101-2020_03_27_012757 475 6 type type NN 10_1101-2020_03_27_012757 475 7 of of IN 10_1101-2020_03_27_012757 475 8 the the DT 10_1101-2020_03_27_012757 475 9 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 475 10 , , , 10_1101-2020_03_27_012757 475 11 and and CC 10_1101-2020_03_27_012757 475 12 898 898 CD 10_1101-2020_03_27_012757 475 13 row row NN 10_1101-2020_03_27_012757 475 14 names name NNS 10_1101-2020_03_27_012757 475 15 represent represent VBP 10_1101-2020_03_27_012757 475 16 cancer cancer NN 10_1101-2020_03_27_012757 475 17 categories category NNS 10_1101-2020_03_27_012757 475 18 . . . 10_1101-2020_03_27_012757 476 1 ( ( -LRB- 10_1101-2020_03_27_012757 476 2 B b NN 10_1101-2020_03_27_012757 476 3 ) ) -RRB- 10_1101-2020_03_27_012757 476 4 Proportion proportion NN 10_1101-2020_03_27_012757 476 5 of of IN 10_1101-2020_03_27_012757 476 6 classification classification NN 10_1101-2020_03_27_012757 476 7 categories category NNS 10_1101-2020_03_27_012757 476 8 in in IN 10_1101-2020_03_27_012757 476 9 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 476 10 899 899 CD 10_1101-2020_03_27_012757 476 11 across across IN 10_1101-2020_03_27_012757 476 12 cancer cancer NN 10_1101-2020_03_27_012757 476 13 types type NNS 10_1101-2020_03_27_012757 476 14 is be VBZ 10_1101-2020_03_27_012757 476 15 visualized visualize VBN 10_1101-2020_03_27_012757 476 16 in in IN 10_1101-2020_03_27_012757 476 17 the the DT 10_1101-2020_03_27_012757 476 18 bar bar NN 10_1101-2020_03_27_012757 476 19 plot plot NN 10_1101-2020_03_27_012757 476 20 and and CC 10_1101-2020_03_27_012757 476 21 ordered order VBN 10_1101-2020_03_27_012757 476 22 from from IN 10_1101-2020_03_27_012757 476 23 the the DT 10_1101-2020_03_27_012757 476 24 cancer cancer NN 10_1101-2020_03_27_012757 476 25 type type NN 10_1101-2020_03_27_012757 476 26 with with IN 10_1101-2020_03_27_012757 476 27 highest high JJS 10_1101-2020_03_27_012757 476 28 900 900 CD 10_1101-2020_03_27_012757 476 29 proportion proportion NN 10_1101-2020_03_27_012757 476 30 of of IN 10_1101-2020_03_27_012757 476 31 correct correct JJ 10_1101-2020_03_27_012757 476 32 and and CC 10_1101-2020_03_27_012757 476 33 mixed mixed JJ 10_1101-2020_03_27_012757 476 34 correct correct JJ 10_1101-2020_03_27_012757 476 35 classified classify VBD 10_1101-2020_03_27_012757 476 36 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 476 37 to to IN 10_1101-2020_03_27_012757 476 38 the the DT 10_1101-2020_03_27_012757 476 39 lowest low JJS 10_1101-2020_03_27_012757 476 40 . . . 10_1101-2020_03_27_012757 477 1 Subtype subtype NN 10_1101-2020_03_27_012757 477 2 classification classification NN 10_1101-2020_03_27_012757 477 3 901 901 CD 10_1101-2020_03_27_012757 477 4 heatmap heatmap NN 10_1101-2020_03_27_012757 477 5 of of IN 10_1101-2020_03_27_012757 477 6 ( ( -LRB- 10_1101-2020_03_27_012757 477 7 C C NNP 10_1101-2020_03_27_012757 477 8 ) ) -RRB- 10_1101-2020_03_27_012757 477 9 UCEC UCEC NNP 10_1101-2020_03_27_012757 477 10 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 477 11 , , , 10_1101-2020_03_27_012757 477 12 ( ( -LRB- 10_1101-2020_03_27_012757 477 13 D d NN 10_1101-2020_03_27_012757 477 14 ) ) -RRB- 10_1101-2020_03_27_012757 477 15 LUSC LUSC NNP 10_1101-2020_03_27_012757 477 16 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 477 17 and and CC 10_1101-2020_03_27_012757 477 18 ( ( -LRB- 10_1101-2020_03_27_012757 477 19 E e NN 10_1101-2020_03_27_012757 477 20 ) ) -RRB- 10_1101-2020_03_27_012757 477 21 LUAD luad RB 10_1101-2020_03_27_012757 477 22 GEMMs gemm NNS 10_1101-2020_03_27_012757 477 23 . . . 10_1101-2020_03_27_012757 478 1 Only only RB 10_1101-2020_03_27_012757 478 2 samples sample NNS 10_1101-2020_03_27_012757 478 3 with with IN 10_1101-2020_03_27_012757 478 4 902 902 CD 10_1101-2020_03_27_012757 478 5 CCN CCN NNP 10_1101-2020_03_27_012757 478 6 scores score NNS 10_1101-2020_03_27_012757 478 7 > > XX 10_1101-2020_03_27_012757 478 8 0.1 0.1 CD 10_1101-2020_03_27_012757 478 9 in in IN 10_1101-2020_03_27_012757 478 10 their -PRON- PRP$ 10_1101-2020_03_27_012757 478 11 nominal nominal JJ 10_1101-2020_03_27_012757 478 12 tumor tumor NN 10_1101-2020_03_27_012757 478 13 type type NN 10_1101-2020_03_27_012757 478 14 are be VBP 10_1101-2020_03_27_012757 478 15 displayed display VBN 10_1101-2020_03_27_012757 478 16 . . . 10_1101-2020_03_27_012757 479 1 903 903 CD 10_1101-2020_03_27_012757 479 2 .CC .CC : 10_1101-2020_03_27_012757 479 3 - - HYPH 10_1101-2020_03_27_012757 479 4 BY by IN 10_1101-2020_03_27_012757 479 5 - - HYPH 10_1101-2020_03_27_012757 479 6 NC NC NNP 10_1101-2020_03_27_012757 479 7 - - HYPH 10_1101-2020_03_27_012757 479 8 ND ND NNP 10_1101-2020_03_27_012757 479 9 4.0 4.0 CD 10_1101-2020_03_27_012757 479 10 International International NNP 10_1101-2020_03_27_012757 479 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 479 12 under under IN 10_1101-2020_03_27_012757 479 13 a a DT 10_1101-2020_03_27_012757 479 14 ( ( -LRB- 10_1101-2020_03_27_012757 479 15 which which WDT 10_1101-2020_03_27_012757 479 16 was be VBD 10_1101-2020_03_27_012757 479 17 not not RB 10_1101-2020_03_27_012757 479 18 certified certify VBN 10_1101-2020_03_27_012757 479 19 by by IN 10_1101-2020_03_27_012757 479 20 peer peer NN 10_1101-2020_03_27_012757 479 21 review review NN 10_1101-2020_03_27_012757 479 22 ) ) -RRB- 10_1101-2020_03_27_012757 479 23 is be VBZ 10_1101-2020_03_27_012757 479 24 the the DT 10_1101-2020_03_27_012757 479 25 author author NN 10_1101-2020_03_27_012757 479 26 / / SYM 10_1101-2020_03_27_012757 479 27 funder funder NN 10_1101-2020_03_27_012757 479 28 , , , 10_1101-2020_03_27_012757 479 29 who who WP 10_1101-2020_03_27_012757 479 30 has have VBZ 10_1101-2020_03_27_012757 479 31 granted grant VBN 10_1101-2020_03_27_012757 479 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 479 33 a a DT 10_1101-2020_03_27_012757 479 34 license license NN 10_1101-2020_03_27_012757 479 35 to to TO 10_1101-2020_03_27_012757 479 36 display display VB 10_1101-2020_03_27_012757 479 37 the the DT 10_1101-2020_03_27_012757 479 38 preprint preprint NN 10_1101-2020_03_27_012757 479 39 in in IN 10_1101-2020_03_27_012757 479 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 479 41 . . . 10_1101-2020_03_27_012757 480 1 It -PRON- PRP 10_1101-2020_03_27_012757 480 2 is be VBZ 10_1101-2020_03_27_012757 480 3 made make VBN 10_1101-2020_03_27_012757 480 4 The the DT 10_1101-2020_03_27_012757 480 5 copyright copyright NN 10_1101-2020_03_27_012757 480 6 holder holder NN 10_1101-2020_03_27_012757 480 7 for for IN 10_1101-2020_03_27_012757 480 8 this this DT 10_1101-2020_03_27_012757 480 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 480 10 version version NN 10_1101-2020_03_27_012757 480 11 posted post VBD 10_1101-2020_03_27_012757 480 12 January January NNP 10_1101-2020_03_27_012757 480 13 9 9 CD 10_1101-2020_03_27_012757 480 14 , , , 10_1101-2020_03_27_012757 480 15 2021 2021 CD 10_1101-2020_03_27_012757 480 16 . . . 10_1101-2020_03_27_012757 480 17 ; ; : 10_1101-2020_03_27_012757 480 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 480 19 : : : 10_1101-2020_03_27_012757 480 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 480 21 preprint preprint NN 10_1101-2020_03_27_012757 480 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 480 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 480 24 35 35 CD 10_1101-2020_03_27_012757 480 25 904 904 CD 10_1101-2020_03_27_012757 480 26 Fig fig NN 10_1101-2020_03_27_012757 480 27 . . . 10_1101-2020_03_27_012757 481 1 7 7 CD 10_1101-2020_03_27_012757 481 2 Evaluation evaluation NN 10_1101-2020_03_27_012757 481 3 of of IN 10_1101-2020_03_27_012757 481 4 tumoroid tumoroid NN 10_1101-2020_03_27_012757 481 5 models model NNS 10_1101-2020_03_27_012757 481 6 . . . 10_1101-2020_03_27_012757 482 1 ( ( -LRB- 10_1101-2020_03_27_012757 482 2 A a DT 10_1101-2020_03_27_012757 482 3 ) ) -RRB- 10_1101-2020_03_27_012757 482 4 General General NNP 10_1101-2020_03_27_012757 482 5 classification classification NN 10_1101-2020_03_27_012757 482 6 heatmap heatmap NN 10_1101-2020_03_27_012757 482 7 of of IN 10_1101-2020_03_27_012757 482 8 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 482 9 . . . 10_1101-2020_03_27_012757 483 1 905 905 CD 10_1101-2020_03_27_012757 483 2 Column column NN 10_1101-2020_03_27_012757 483 3 annotations annotation NNS 10_1101-2020_03_27_012757 483 4 represent represent VBP 10_1101-2020_03_27_012757 483 5 annotated annotate VBN 10_1101-2020_03_27_012757 483 6 cancer cancer NN 10_1101-2020_03_27_012757 483 7 type type NN 10_1101-2020_03_27_012757 483 8 of of IN 10_1101-2020_03_27_012757 483 9 the the DT 10_1101-2020_03_27_012757 483 10 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 483 11 , , , 10_1101-2020_03_27_012757 483 12 and and CC 10_1101-2020_03_27_012757 483 13 row row NN 10_1101-2020_03_27_012757 483 14 names name NNS 10_1101-2020_03_27_012757 483 15 906 906 CD 10_1101-2020_03_27_012757 483 16 represent represent NN 10_1101-2020_03_27_012757 483 17 cancer cancer NN 10_1101-2020_03_27_012757 483 18 categories category NNS 10_1101-2020_03_27_012757 483 19 . . . 10_1101-2020_03_27_012757 484 1 ( ( -LRB- 10_1101-2020_03_27_012757 484 2 B b NN 10_1101-2020_03_27_012757 484 3 ) ) -RRB- 10_1101-2020_03_27_012757 484 4 Proportion proportion NN 10_1101-2020_03_27_012757 484 5 of of IN 10_1101-2020_03_27_012757 484 6 classification classification NN 10_1101-2020_03_27_012757 484 7 categories category NNS 10_1101-2020_03_27_012757 484 8 in in IN 10_1101-2020_03_27_012757 484 9 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 484 10 across across IN 10_1101-2020_03_27_012757 484 11 907 907 CD 10_1101-2020_03_27_012757 484 12 cancer cancer NN 10_1101-2020_03_27_012757 484 13 types type NNS 10_1101-2020_03_27_012757 484 14 is be VBZ 10_1101-2020_03_27_012757 484 15 visualized visualize VBN 10_1101-2020_03_27_012757 484 16 in in IN 10_1101-2020_03_27_012757 484 17 the the DT 10_1101-2020_03_27_012757 484 18 bar bar NN 10_1101-2020_03_27_012757 484 19 plot plot NN 10_1101-2020_03_27_012757 484 20 and and CC 10_1101-2020_03_27_012757 484 21 ordered order VBN 10_1101-2020_03_27_012757 484 22 from from IN 10_1101-2020_03_27_012757 484 23 the the DT 10_1101-2020_03_27_012757 484 24 cancer cancer NN 10_1101-2020_03_27_012757 484 25 type type NN 10_1101-2020_03_27_012757 484 26 with with IN 10_1101-2020_03_27_012757 484 27 highest high JJS 10_1101-2020_03_27_012757 484 28 908 908 CD 10_1101-2020_03_27_012757 484 29 proportion proportion NN 10_1101-2020_03_27_012757 484 30 of of IN 10_1101-2020_03_27_012757 484 31 correct correct JJ 10_1101-2020_03_27_012757 484 32 and and CC 10_1101-2020_03_27_012757 484 33 mixed mixed JJ 10_1101-2020_03_27_012757 484 34 correct correct JJ 10_1101-2020_03_27_012757 484 35 classified classified JJ 10_1101-2020_03_27_012757 484 36 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 484 37 to to IN 10_1101-2020_03_27_012757 484 38 the the DT 10_1101-2020_03_27_012757 484 39 lowest low JJS 10_1101-2020_03_27_012757 484 40 . . . 10_1101-2020_03_27_012757 485 1 Subtype subtype NN 10_1101-2020_03_27_012757 485 2 classification classification NN 10_1101-2020_03_27_012757 485 3 909 909 CD 10_1101-2020_03_27_012757 485 4 heatmap heatmap NN 10_1101-2020_03_27_012757 485 5 of of IN 10_1101-2020_03_27_012757 485 6 ( ( -LRB- 10_1101-2020_03_27_012757 485 7 C C NNP 10_1101-2020_03_27_012757 485 8 ) ) -RRB- 10_1101-2020_03_27_012757 485 9 UCEC UCEC NNP 10_1101-2020_03_27_012757 485 10 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 485 11 , , , 10_1101-2020_03_27_012757 485 12 ( ( -LRB- 10_1101-2020_03_27_012757 485 13 D d NN 10_1101-2020_03_27_012757 485 14 ) ) -RRB- 10_1101-2020_03_27_012757 485 15 LUSC LUSC NNP 10_1101-2020_03_27_012757 485 16 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 485 17 and and CC 10_1101-2020_03_27_012757 485 18 ( ( -LRB- 10_1101-2020_03_27_012757 485 19 E e NN 10_1101-2020_03_27_012757 485 20 ) ) -RRB- 10_1101-2020_03_27_012757 485 21 LUAD luad RB 10_1101-2020_03_27_012757 485 22 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 485 23 . . . 10_1101-2020_03_27_012757 486 1 Only only RB 10_1101-2020_03_27_012757 486 2 samples sample NNS 10_1101-2020_03_27_012757 486 3 910 910 CD 10_1101-2020_03_27_012757 486 4 with with IN 10_1101-2020_03_27_012757 486 5 CCN CCN NNP 10_1101-2020_03_27_012757 486 6 scores score NNS 10_1101-2020_03_27_012757 486 7 > > XX 10_1101-2020_03_27_012757 486 8 0.1 0.1 CD 10_1101-2020_03_27_012757 486 9 in in IN 10_1101-2020_03_27_012757 486 10 their -PRON- PRP$ 10_1101-2020_03_27_012757 486 11 nominal nominal JJ 10_1101-2020_03_27_012757 486 12 tumor tumor NN 10_1101-2020_03_27_012757 486 13 type type NN 10_1101-2020_03_27_012757 486 14 are be VBP 10_1101-2020_03_27_012757 486 15 displayed display VBN 10_1101-2020_03_27_012757 486 16 . . . 10_1101-2020_03_27_012757 487 1 911 911 CD 10_1101-2020_03_27_012757 487 2 912 912 CD 10_1101-2020_03_27_012757 487 3 Fig fig NN 10_1101-2020_03_27_012757 487 4 . . . 10_1101-2020_03_27_012757 488 1 8 8 CD 10_1101-2020_03_27_012757 488 2 Comparison Comparison NNP 10_1101-2020_03_27_012757 488 3 of of IN 10_1101-2020_03_27_012757 488 4 CCLs CCLs NNPS 10_1101-2020_03_27_012757 488 5 , , , 10_1101-2020_03_27_012757 488 6 PDXs pdx NNS 10_1101-2020_03_27_012757 488 7 , , , 10_1101-2020_03_27_012757 488 8 and and CC 10_1101-2020_03_27_012757 488 9 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 488 10 . . . 10_1101-2020_03_27_012757 489 1 Box Box NNP 10_1101-2020_03_27_012757 489 2 - - HYPH 10_1101-2020_03_27_012757 489 3 and and CC 10_1101-2020_03_27_012757 489 4 - - HYPH 10_1101-2020_03_27_012757 489 5 whiskers whisker NNS 10_1101-2020_03_27_012757 489 6 plot plot NN 10_1101-2020_03_27_012757 489 7 comparing compare VBG 10_1101-2020_03_27_012757 489 8 general general JJ 10_1101-2020_03_27_012757 489 9 913 913 CD 10_1101-2020_03_27_012757 489 10 CCN CCN NNP 10_1101-2020_03_27_012757 489 11 scores score NNS 10_1101-2020_03_27_012757 489 12 across across IN 10_1101-2020_03_27_012757 489 13 CCLs ccl NNS 10_1101-2020_03_27_012757 489 14 , , , 10_1101-2020_03_27_012757 489 15 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 489 16 , , , 10_1101-2020_03_27_012757 489 17 PDXs pdx NNS 10_1101-2020_03_27_012757 489 18 of of IN 10_1101-2020_03_27_012757 489 19 five five CD 10_1101-2020_03_27_012757 489 20 general general JJ 10_1101-2020_03_27_012757 489 21 tumor tumor NN 10_1101-2020_03_27_012757 489 22 types type NNS 10_1101-2020_03_27_012757 489 23 ( ( -LRB- 10_1101-2020_03_27_012757 489 24 UCEC UCEC NNP 10_1101-2020_03_27_012757 489 25 , , , 10_1101-2020_03_27_012757 489 26 PAAD PAAD NNP 10_1101-2020_03_27_012757 489 27 , , , 10_1101-2020_03_27_012757 489 28 LUSC LUSC NNP 10_1101-2020_03_27_012757 489 29 , , , 10_1101-2020_03_27_012757 489 30 914 914 CD 10_1101-2020_03_27_012757 489 31 LUAD luad RB 10_1101-2020_03_27_012757 489 32 , , , 10_1101-2020_03_27_012757 489 33 LIHC LIHC NNP 10_1101-2020_03_27_012757 489 34 ) ) -RRB- 10_1101-2020_03_27_012757 489 35 . . . 10_1101-2020_03_27_012757 490 1 915 915 CD 10_1101-2020_03_27_012757 490 2 916 916 CD 10_1101-2020_03_27_012757 490 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 490 4 Information information NN 10_1101-2020_03_27_012757 490 5 917 917 CD 10_1101-2020_03_27_012757 490 6 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 490 7 Figure figure NN 10_1101-2020_03_27_012757 490 8 1 1 CD 10_1101-2020_03_27_012757 490 9 Assessment Assessment NNP 10_1101-2020_03_27_012757 490 10 of of IN 10_1101-2020_03_27_012757 490 11 CCN CCN NNP 10_1101-2020_03_27_012757 490 12 general general JJ 10_1101-2020_03_27_012757 490 13 classifier classifier NN 10_1101-2020_03_27_012757 490 14 and and CC 10_1101-2020_03_27_012757 490 15 subtype subtype NN 10_1101-2020_03_27_012757 490 16 classifier classifier NN 10_1101-2020_03_27_012757 490 17 . . . 10_1101-2020_03_27_012757 491 1 ( ( -LRB- 10_1101-2020_03_27_012757 491 2 A a DT 10_1101-2020_03_27_012757 491 3 ) ) -RRB- 10_1101-2020_03_27_012757 491 4 918 918 CD 10_1101-2020_03_27_012757 491 5 Mean Mean NNP 10_1101-2020_03_27_012757 491 6 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 491 7 of of IN 10_1101-2020_03_27_012757 491 8 repeated repeat VBN 10_1101-2020_03_27_012757 491 9 grid grid NN 10_1101-2020_03_27_012757 491 10 - - HYPH 10_1101-2020_03_27_012757 491 11 search search NN 10_1101-2020_03_27_012757 491 12 cross cross NN 10_1101-2020_03_27_012757 491 13 - - NN 10_1101-2020_03_27_012757 491 14 validation validation NN 10_1101-2020_03_27_012757 491 15 for for IN 10_1101-2020_03_27_012757 491 16 each each DT 10_1101-2020_03_27_012757 491 17 parameter parameter NN 10_1101-2020_03_27_012757 491 18 grid grid NN 10_1101-2020_03_27_012757 491 19 . . . 10_1101-2020_03_27_012757 492 1 ( ( -LRB- 10_1101-2020_03_27_012757 492 2 B b NN 10_1101-2020_03_27_012757 492 3 ) ) -RRB- 10_1101-2020_03_27_012757 492 4 Mean Mean NNP 10_1101-2020_03_27_012757 492 5 and and CC 10_1101-2020_03_27_012757 492 6 919 919 CD 10_1101-2020_03_27_012757 492 7 range range NN 10_1101-2020_03_27_012757 492 8 of of IN 10_1101-2020_03_27_012757 492 9 CCN CCN NNP 10_1101-2020_03_27_012757 492 10 classifier classifier NN 10_1101-2020_03_27_012757 492 11 ’s ’s NN 10_1101-2020_03_27_012757 492 12 PR pr NN 10_1101-2020_03_27_012757 492 13 curves curve NNS 10_1101-2020_03_27_012757 492 14 from from IN 10_1101-2020_03_27_012757 492 15 50 50 CD 10_1101-2020_03_27_012757 492 16 cross cross NN 10_1101-2020_03_27_012757 492 17 validations validation NNS 10_1101-2020_03_27_012757 492 18 based base VBN 10_1101-2020_03_27_012757 492 19 on on IN 10_1101-2020_03_27_012757 492 20 the the DT 10_1101-2020_03_27_012757 492 21 optimal optimal JJ 10_1101-2020_03_27_012757 492 22 feature feature NN 10_1101-2020_03_27_012757 492 23 920 920 CD 10_1101-2020_03_27_012757 492 24 selection selection NN 10_1101-2020_03_27_012757 492 25 parameters parameter NNS 10_1101-2020_03_27_012757 492 26 n n NN 10_1101-2020_03_27_012757 492 27 and and CC 10_1101-2020_03_27_012757 492 28 m. m. NN 10_1101-2020_03_27_012757 492 29 ( ( -LRB- 10_1101-2020_03_27_012757 492 30 C C NNP 10_1101-2020_03_27_012757 492 31 ) ) -RRB- 10_1101-2020_03_27_012757 492 32 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 492 33 of of IN 10_1101-2020_03_27_012757 492 34 CCN CCN NNP 10_1101-2020_03_27_012757 492 35 human human JJ 10_1101-2020_03_27_012757 492 36 tissue tissue NN 10_1101-2020_03_27_012757 492 37 classifier classifier NN 10_1101-2020_03_27_012757 492 38 when when WRB 10_1101-2020_03_27_012757 492 39 applied apply VBN 10_1101-2020_03_27_012757 492 40 to to IN 10_1101-2020_03_27_012757 492 41 921 921 CD 10_1101-2020_03_27_012757 492 42 mouse mouse NN 10_1101-2020_03_27_012757 492 43 tissue tissue NN 10_1101-2020_03_27_012757 492 44 data datum NNS 10_1101-2020_03_27_012757 492 45 . . . 10_1101-2020_03_27_012757 493 1 ( ( -LRB- 10_1101-2020_03_27_012757 493 2 D d NN 10_1101-2020_03_27_012757 493 3 ) ) -RRB- 10_1101-2020_03_27_012757 493 4 The the DT 10_1101-2020_03_27_012757 493 5 schematic schematic NN 10_1101-2020_03_27_012757 493 6 of of IN 10_1101-2020_03_27_012757 493 7 training train VBG 10_1101-2020_03_27_012757 493 8 a a DT 10_1101-2020_03_27_012757 493 9 subtype subtype NN 10_1101-2020_03_27_012757 493 10 classifier classifier NN 10_1101-2020_03_27_012757 493 11 in in IN 10_1101-2020_03_27_012757 493 12 CCN CCN NNP 10_1101-2020_03_27_012757 493 13 . . . 10_1101-2020_03_27_012757 494 1 CCN CCN NNP 10_1101-2020_03_27_012757 494 2 uses use VBZ 10_1101-2020_03_27_012757 494 3 patient patient JJ 10_1101-2020_03_27_012757 494 4 922 922 CD 10_1101-2020_03_27_012757 494 5 tumor tumor NN 10_1101-2020_03_27_012757 494 6 expression expression NN 10_1101-2020_03_27_012757 494 7 profiles profile NNS 10_1101-2020_03_27_012757 494 8 from from IN 10_1101-2020_03_27_012757 494 9 cancer cancer NN 10_1101-2020_03_27_012757 494 10 of of IN 10_1101-2020_03_27_012757 494 11 interest interest NN 10_1101-2020_03_27_012757 494 12 as as IN 10_1101-2020_03_27_012757 494 13 training training NN 10_1101-2020_03_27_012757 494 14 data datum NNS 10_1101-2020_03_27_012757 494 15 . . . 10_1101-2020_03_27_012757 495 1 CCN CCN NNP 10_1101-2020_03_27_012757 495 2 performs perform VBZ 10_1101-2020_03_27_012757 495 3 gene gene NN 10_1101-2020_03_27_012757 495 4 - - HYPH 10_1101-2020_03_27_012757 495 5 pair pair VB 10_1101-2020_03_27_012757 495 6 923 923 CD 10_1101-2020_03_27_012757 495 7 transformation transformation NN 10_1101-2020_03_27_012757 495 8 and and CC 10_1101-2020_03_27_012757 495 9 selects select VBZ 10_1101-2020_03_27_012757 495 10 the the DT 10_1101-2020_03_27_012757 495 11 most most RBS 10_1101-2020_03_27_012757 495 12 discriminative discriminative JJ 10_1101-2020_03_27_012757 495 13 gene gene NN 10_1101-2020_03_27_012757 495 14 pairs pair NNS 10_1101-2020_03_27_012757 495 15 among among IN 10_1101-2020_03_27_012757 495 16 the the DT 10_1101-2020_03_27_012757 495 17 cancer cancer NN 10_1101-2020_03_27_012757 495 18 subtypes subtype NNS 10_1101-2020_03_27_012757 495 19 from from IN 10_1101-2020_03_27_012757 495 20 924 924 CD 10_1101-2020_03_27_012757 495 21 training training NN 10_1101-2020_03_27_012757 495 22 data datum NNS 10_1101-2020_03_27_012757 495 23 as as IN 10_1101-2020_03_27_012757 495 24 features feature NNS 10_1101-2020_03_27_012757 495 25 . . . 10_1101-2020_03_27_012757 496 1 CCN CCN NNP 10_1101-2020_03_27_012757 496 2 then then RB 10_1101-2020_03_27_012757 496 3 applies apply VBZ 10_1101-2020_03_27_012757 496 4 the the DT 10_1101-2020_03_27_012757 496 5 general general JJ 10_1101-2020_03_27_012757 496 6 classification classification NN 10_1101-2020_03_27_012757 496 7 on on IN 10_1101-2020_03_27_012757 496 8 training train VBG 10_1101-2020_03_27_012757 496 9 data datum NNS 10_1101-2020_03_27_012757 496 10 and and CC 10_1101-2020_03_27_012757 496 11 uses use VBZ 10_1101-2020_03_27_012757 496 12 925 925 CD 10_1101-2020_03_27_012757 496 13 the the DT 10_1101-2020_03_27_012757 496 14 general general JJ 10_1101-2020_03_27_012757 496 15 classification classification NN 10_1101-2020_03_27_012757 496 16 profile profile NN 10_1101-2020_03_27_012757 496 17 as as IN 10_1101-2020_03_27_012757 496 18 features feature VBZ 10_1101-2020_03_27_012757 496 19 in in IN 10_1101-2020_03_27_012757 496 20 addition addition NN 10_1101-2020_03_27_012757 496 21 to to TO 10_1101-2020_03_27_012757 496 22 gene gene VB 10_1101-2020_03_27_012757 496 23 pairs pair NNS 10_1101-2020_03_27_012757 496 24 for for IN 10_1101-2020_03_27_012757 496 25 training train VBG 10_1101-2020_03_27_012757 496 26 a a DT 10_1101-2020_03_27_012757 496 27 Random Random NNP 10_1101-2020_03_27_012757 496 28 926 926 CD 10_1101-2020_03_27_012757 496 29 Forest Forest NNP 10_1101-2020_03_27_012757 496 30 classifier classifier NN 10_1101-2020_03_27_012757 496 31 . . . 10_1101-2020_03_27_012757 497 1 The the DT 10_1101-2020_03_27_012757 497 2 weight weight NN 10_1101-2020_03_27_012757 497 3 of of IN 10_1101-2020_03_27_012757 497 4 the the DT 10_1101-2020_03_27_012757 497 5 general general JJ 10_1101-2020_03_27_012757 497 6 classification classification NN 10_1101-2020_03_27_012757 497 7 profiles profile NNS 10_1101-2020_03_27_012757 497 8 as as IN 10_1101-2020_03_27_012757 497 9 features feature NNS 10_1101-2020_03_27_012757 497 10 can can MD 10_1101-2020_03_27_012757 497 11 be be VB 10_1101-2020_03_27_012757 497 12 tuned tune VBN 10_1101-2020_03_27_012757 497 13 to to IN 10_1101-2020_03_27_012757 497 14 927 927 CD 10_1101-2020_03_27_012757 497 15 improve improve VB 10_1101-2020_03_27_012757 497 16 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 497 17 . . . 10_1101-2020_03_27_012757 498 1 ( ( -LRB- 10_1101-2020_03_27_012757 498 2 E e NN 10_1101-2020_03_27_012757 498 3 ) ) -RRB- 10_1101-2020_03_27_012757 498 4 The the DT 10_1101-2020_03_27_012757 498 5 mean mean JJ 10_1101-2020_03_27_012757 498 6 and and CC 10_1101-2020_03_27_012757 498 7 standard standard JJ 10_1101-2020_03_27_012757 498 8 deviation deviation NN 10_1101-2020_03_27_012757 498 9 of of IN 10_1101-2020_03_27_012757 498 10 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 498 11 for for IN 10_1101-2020_03_27_012757 498 12 11 11 CD 10_1101-2020_03_27_012757 498 13 subtype subtype NN 10_1101-2020_03_27_012757 498 14 classifiers classifier NNS 10_1101-2020_03_27_012757 498 15 928 928 CD 10_1101-2020_03_27_012757 498 16 based base VBN 10_1101-2020_03_27_012757 498 17 on on IN 10_1101-2020_03_27_012757 498 18 20 20 CD 10_1101-2020_03_27_012757 498 19 iterations iteration NNS 10_1101-2020_03_27_012757 498 20 of of IN 10_1101-2020_03_27_012757 498 21 random random JJ 10_1101-2020_03_27_012757 498 22 sampling sampling NN 10_1101-2020_03_27_012757 498 23 of of IN 10_1101-2020_03_27_012757 498 24 training training NN 10_1101-2020_03_27_012757 498 25 and and CC 10_1101-2020_03_27_012757 498 26 held hold VBN 10_1101-2020_03_27_012757 498 27 - - HYPH 10_1101-2020_03_27_012757 498 28 out out RP 10_1101-2020_03_27_012757 498 29 data data NN 10_1101-2020_03_27_012757 498 30 , , , 10_1101-2020_03_27_012757 498 31 training training NN 10_1101-2020_03_27_012757 498 32 subtype subtype NN 10_1101-2020_03_27_012757 498 33 929 929 CD 10_1101-2020_03_27_012757 498 34 .CC .CC , 10_1101-2020_03_27_012757 498 35 - - HYPH 10_1101-2020_03_27_012757 498 36 BY by IN 10_1101-2020_03_27_012757 498 37 - - HYPH 10_1101-2020_03_27_012757 498 38 NC NC NNP 10_1101-2020_03_27_012757 498 39 - - HYPH 10_1101-2020_03_27_012757 498 40 ND ND NNP 10_1101-2020_03_27_012757 498 41 4.0 4.0 CD 10_1101-2020_03_27_012757 498 42 International International NNP 10_1101-2020_03_27_012757 498 43 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 498 44 under under IN 10_1101-2020_03_27_012757 498 45 a a DT 10_1101-2020_03_27_012757 498 46 ( ( -LRB- 10_1101-2020_03_27_012757 498 47 which which WDT 10_1101-2020_03_27_012757 498 48 was be VBD 10_1101-2020_03_27_012757 498 49 not not RB 10_1101-2020_03_27_012757 498 50 certified certify VBN 10_1101-2020_03_27_012757 498 51 by by IN 10_1101-2020_03_27_012757 498 52 peer peer NN 10_1101-2020_03_27_012757 498 53 review review NN 10_1101-2020_03_27_012757 498 54 ) ) -RRB- 10_1101-2020_03_27_012757 498 55 is be VBZ 10_1101-2020_03_27_012757 498 56 the the DT 10_1101-2020_03_27_012757 498 57 author author NN 10_1101-2020_03_27_012757 498 58 / / SYM 10_1101-2020_03_27_012757 498 59 funder funder NN 10_1101-2020_03_27_012757 498 60 , , , 10_1101-2020_03_27_012757 498 61 who who WP 10_1101-2020_03_27_012757 498 62 has have VBZ 10_1101-2020_03_27_012757 498 63 granted grant VBN 10_1101-2020_03_27_012757 498 64 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 498 65 a a DT 10_1101-2020_03_27_012757 498 66 license license NN 10_1101-2020_03_27_012757 498 67 to to TO 10_1101-2020_03_27_012757 498 68 display display VB 10_1101-2020_03_27_012757 498 69 the the DT 10_1101-2020_03_27_012757 498 70 preprint preprint NN 10_1101-2020_03_27_012757 498 71 in in IN 10_1101-2020_03_27_012757 498 72 perpetuity perpetuity NN 10_1101-2020_03_27_012757 498 73 . . . 10_1101-2020_03_27_012757 499 1 It -PRON- PRP 10_1101-2020_03_27_012757 499 2 is be VBZ 10_1101-2020_03_27_012757 499 3 made make VBN 10_1101-2020_03_27_012757 499 4 The the DT 10_1101-2020_03_27_012757 499 5 copyright copyright NN 10_1101-2020_03_27_012757 499 6 holder holder NN 10_1101-2020_03_27_012757 499 7 for for IN 10_1101-2020_03_27_012757 499 8 this this DT 10_1101-2020_03_27_012757 499 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 499 10 version version NN 10_1101-2020_03_27_012757 499 11 posted post VBD 10_1101-2020_03_27_012757 499 12 January January NNP 10_1101-2020_03_27_012757 499 13 9 9 CD 10_1101-2020_03_27_012757 499 14 , , , 10_1101-2020_03_27_012757 499 15 2021 2021 CD 10_1101-2020_03_27_012757 499 16 . . . 10_1101-2020_03_27_012757 499 17 ; ; : 10_1101-2020_03_27_012757 499 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 499 19 : : : 10_1101-2020_03_27_012757 499 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 499 21 preprint preprint NN 10_1101-2020_03_27_012757 499 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 499 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 499 24 36 36 CD 10_1101-2020_03_27_012757 499 25 classifier classifier NN 10_1101-2020_03_27_012757 499 26 using use VBG 10_1101-2020_03_27_012757 499 27 training training NN 10_1101-2020_03_27_012757 499 28 data datum NNS 10_1101-2020_03_27_012757 499 29 , , , 10_1101-2020_03_27_012757 499 30 classification classification NN 10_1101-2020_03_27_012757 499 31 of of IN 10_1101-2020_03_27_012757 499 32 held hold VBN 10_1101-2020_03_27_012757 499 33 - - HYPH 10_1101-2020_03_27_012757 499 34 out out RP 10_1101-2020_03_27_012757 499 35 data data NN 10_1101-2020_03_27_012757 499 36 , , , 10_1101-2020_03_27_012757 499 37 and and CC 10_1101-2020_03_27_012757 499 38 calculation calculation NN 10_1101-2020_03_27_012757 499 39 of of IN 10_1101-2020_03_27_012757 499 40 recall recall NN 10_1101-2020_03_27_012757 499 41 and and CC 10_1101-2020_03_27_012757 499 42 930 930 CD 10_1101-2020_03_27_012757 499 43 precision precision NN 10_1101-2020_03_27_012757 499 44 . . . 10_1101-2020_03_27_012757 500 1 931 931 CD 10_1101-2020_03_27_012757 500 2 932 932 CD 10_1101-2020_03_27_012757 500 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 500 4 Figure figure NN 10_1101-2020_03_27_012757 500 5 2 2 CD 10_1101-2020_03_27_012757 500 6 Further further JJ 10_1101-2020_03_27_012757 500 7 validation validation NN 10_1101-2020_03_27_012757 500 8 of of IN 10_1101-2020_03_27_012757 500 9 CCN ccn NN 10_1101-2020_03_27_012757 500 10 and and CC 10_1101-2020_03_27_012757 500 11 classification classification NN 10_1101-2020_03_27_012757 500 12 results result NNS 10_1101-2020_03_27_012757 500 13 . . . 10_1101-2020_03_27_012757 501 1 To to TO 10_1101-2020_03_27_012757 501 2 validate validate VB 10_1101-2020_03_27_012757 501 3 the the DT 10_1101-2020_03_27_012757 501 4 933 933 CD 10_1101-2020_03_27_012757 501 5 cross cross JJ 10_1101-2020_03_27_012757 501 6 - - JJ 10_1101-2020_03_27_012757 501 7 platform platform JJ 10_1101-2020_03_27_012757 501 8 classification classification NN 10_1101-2020_03_27_012757 501 9 performance performance NN 10_1101-2020_03_27_012757 501 10 of of IN 10_1101-2020_03_27_012757 501 11 CCN CCN NNP 10_1101-2020_03_27_012757 501 12 , , , 10_1101-2020_03_27_012757 501 13 a a DT 10_1101-2020_03_27_012757 501 14 new new JJ 10_1101-2020_03_27_012757 501 15 classifier classifier NN 10_1101-2020_03_27_012757 501 16 specifically specifically RB 10_1101-2020_03_27_012757 501 17 trained train VBN 10_1101-2020_03_27_012757 501 18 to to TO 10_1101-2020_03_27_012757 501 19 classify classify VB 10_1101-2020_03_27_012757 501 20 934 934 CD 10_1101-2020_03_27_012757 501 21 microarray microarray JJ 10_1101-2020_03_27_012757 501 22 data datum NNS 10_1101-2020_03_27_012757 501 23 was be VBD 10_1101-2020_03_27_012757 501 24 trained train VBN 10_1101-2020_03_27_012757 501 25 using use VBG 10_1101-2020_03_27_012757 501 26 RNA RNA NNP 10_1101-2020_03_27_012757 501 27 - - HYPH 10_1101-2020_03_27_012757 501 28 seq seq NN 10_1101-2020_03_27_012757 501 29 data datum NNS 10_1101-2020_03_27_012757 501 30 from from IN 10_1101-2020_03_27_012757 501 31 TCGA TCGA NNP 10_1101-2020_03_27_012757 501 32 as as IN 10_1101-2020_03_27_012757 501 33 training training NN 10_1101-2020_03_27_012757 501 34 data datum NNS 10_1101-2020_03_27_012757 501 35 and and CC 10_1101-2020_03_27_012757 501 36 intersecting intersect VBG 10_1101-2020_03_27_012757 501 37 935 935 CD 10_1101-2020_03_27_012757 501 38 genes gene NNS 10_1101-2020_03_27_012757 501 39 between between IN 10_1101-2020_03_27_012757 501 40 RNA RNA NNP 10_1101-2020_03_27_012757 501 41 - - HYPH 10_1101-2020_03_27_012757 501 42 seq seq NN 10_1101-2020_03_27_012757 501 43 data datum NNS 10_1101-2020_03_27_012757 501 44 and and CC 10_1101-2020_03_27_012757 501 45 microarray microarray JJ 10_1101-2020_03_27_012757 501 46 data datum NNS 10_1101-2020_03_27_012757 501 47 . . . 10_1101-2020_03_27_012757 502 1 ( ( -LRB- 10_1101-2020_03_27_012757 502 2 A a NN 10_1101-2020_03_27_012757 502 3 ) ) -RRB- 10_1101-2020_03_27_012757 502 4 AUPRC AUPRC NNS 10_1101-2020_03_27_012757 502 5 of of IN 10_1101-2020_03_27_012757 502 6 CCN CCN NNP 10_1101-2020_03_27_012757 502 7 classifier classifier NN 10_1101-2020_03_27_012757 502 8 when when WRB 10_1101-2020_03_27_012757 502 9 applied apply VBD 10_1101-2020_03_27_012757 502 10 936 936 CD 10_1101-2020_03_27_012757 502 11 to to IN 10_1101-2020_03_27_012757 502 12 tumor tumor NN 10_1101-2020_03_27_012757 502 13 profiles profile NNS 10_1101-2020_03_27_012757 502 14 assayed assay VBN 10_1101-2020_03_27_012757 502 15 on on IN 10_1101-2020_03_27_012757 502 16 microarrays microarray NNS 10_1101-2020_03_27_012757 502 17 . . . 10_1101-2020_03_27_012757 503 1 ( ( -LRB- 10_1101-2020_03_27_012757 503 2 B b NN 10_1101-2020_03_27_012757 503 3 ) ) -RRB- 10_1101-2020_03_27_012757 503 4 Classification classification NN 10_1101-2020_03_27_012757 503 5 heatmap heatmap NN 10_1101-2020_03_27_012757 503 6 of of IN 10_1101-2020_03_27_012757 503 7 CCLs CCLs NNP 10_1101-2020_03_27_012757 503 8 using use VBG 10_1101-2020_03_27_012757 503 9 microarray microarray JJ 10_1101-2020_03_27_012757 503 10 937 937 CD 10_1101-2020_03_27_012757 503 11 expression expression NN 10_1101-2020_03_27_012757 503 12 data datum NNS 10_1101-2020_03_27_012757 503 13 . . . 10_1101-2020_03_27_012757 504 1 ( ( -LRB- 10_1101-2020_03_27_012757 504 2 C C NNP 10_1101-2020_03_27_012757 504 3 ) ) -RRB- 10_1101-2020_03_27_012757 504 4 Pearson Pearson NNP 10_1101-2020_03_27_012757 504 5 correlation correlation NN 10_1101-2020_03_27_012757 504 6 between between IN 10_1101-2020_03_27_012757 504 7 CCN CCN NNP 10_1101-2020_03_27_012757 504 8 scores score NNS 10_1101-2020_03_27_012757 504 9 of of IN 10_1101-2020_03_27_012757 504 10 CCLE ccle JJ 10_1101-2020_03_27_012757 504 11 lines line NNS 10_1101-2020_03_27_012757 504 12 generated generate VBN 10_1101-2020_03_27_012757 504 13 from from IN 10_1101-2020_03_27_012757 504 14 938 938 CD 10_1101-2020_03_27_012757 504 15 RNA RNA NNP 10_1101-2020_03_27_012757 504 16 - - HYPH 10_1101-2020_03_27_012757 504 17 seq seq NN 10_1101-2020_03_27_012757 504 18 data datum NNS 10_1101-2020_03_27_012757 504 19 and and CC 10_1101-2020_03_27_012757 504 20 microarray microarray JJ 10_1101-2020_03_27_012757 504 21 data datum NNS 10_1101-2020_03_27_012757 504 22 . . . 10_1101-2020_03_27_012757 505 1 ( ( -LRB- 10_1101-2020_03_27_012757 505 2 D d NN 10_1101-2020_03_27_012757 505 3 ) ) -RRB- 10_1101-2020_03_27_012757 505 4 Comparison comparison NN 10_1101-2020_03_27_012757 505 5 between between IN 10_1101-2020_03_27_012757 505 6 CCLs CCLs NNP 10_1101-2020_03_27_012757 505 7 ’ ’ POS 10_1101-2020_03_27_012757 505 8 CCN CCN NNP 10_1101-2020_03_27_012757 505 9 scores score NNS 10_1101-2020_03_27_012757 505 10 and and CC 10_1101-2020_03_27_012757 505 11 the the DT 10_1101-2020_03_27_012757 505 12 939 939 CD 10_1101-2020_03_27_012757 505 13 similarity similarity NN 10_1101-2020_03_27_012757 505 14 metric metric NN 10_1101-2020_03_27_012757 505 15 from from IN 10_1101-2020_03_27_012757 505 16 Yu Yu NNP 10_1101-2020_03_27_012757 505 17 et et NNP 10_1101-2020_03_27_012757 505 18 al15 al15 NNP 10_1101-2020_03_27_012757 505 19 , , , 10_1101-2020_03_27_012757 505 20 median median JJ 10_1101-2020_03_27_012757 505 21 correlations correlation NNS 10_1101-2020_03_27_012757 505 22 of of IN 10_1101-2020_03_27_012757 505 23 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 505 24 profiles profile NNS 10_1101-2020_03_27_012757 505 25 between between IN 10_1101-2020_03_27_012757 505 26 CCLs CCLs NNP 10_1101-2020_03_27_012757 505 27 940 940 CD 10_1101-2020_03_27_012757 505 28 and and CC 10_1101-2020_03_27_012757 505 29 TCGA tcga NN 10_1101-2020_03_27_012757 505 30 tumors tumor NNS 10_1101-2020_03_27_012757 505 31 from from IN 10_1101-2020_03_27_012757 505 32 CCLs CCLs NNP 10_1101-2020_03_27_012757 505 33 ’ ’ POS 10_1101-2020_03_27_012757 505 34 labelled label VBN 10_1101-2020_03_27_012757 505 35 cancer cancer NN 10_1101-2020_03_27_012757 505 36 category category NN 10_1101-2020_03_27_012757 505 37 . . . 10_1101-2020_03_27_012757 506 1 ( ( -LRB- 10_1101-2020_03_27_012757 506 2 E e NN 10_1101-2020_03_27_012757 506 3 ) ) -RRB- 10_1101-2020_03_27_012757 506 4 Comparison comparison NN 10_1101-2020_03_27_012757 506 5 of of IN 10_1101-2020_03_27_012757 506 6 mean mean JJ 10_1101-2020_03_27_012757 506 7 tumor tumor NN 10_1101-2020_03_27_012757 506 8 purity purity NN 10_1101-2020_03_27_012757 506 9 941 941 CD 10_1101-2020_03_27_012757 506 10 of of IN 10_1101-2020_03_27_012757 506 11 training train VBG 10_1101-2020_03_27_012757 506 12 data datum NNS 10_1101-2020_03_27_012757 506 13 and and CC 10_1101-2020_03_27_012757 506 14 mean mean VB 10_1101-2020_03_27_012757 506 15 CCN CCN NNP 10_1101-2020_03_27_012757 506 16 scores score NNS 10_1101-2020_03_27_012757 506 17 of of IN 10_1101-2020_03_27_012757 506 18 CCLs ccl NNS 10_1101-2020_03_27_012757 506 19 for for IN 10_1101-2020_03_27_012757 506 20 each each DT 10_1101-2020_03_27_012757 506 21 cancer cancer NN 10_1101-2020_03_27_012757 506 22 category category NN 10_1101-2020_03_27_012757 506 23 . . . 10_1101-2020_03_27_012757 507 1 942 942 CD 10_1101-2020_03_27_012757 507 2 943 943 CD 10_1101-2020_03_27_012757 507 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 507 4 Figure figure NN 10_1101-2020_03_27_012757 507 5 3 3 CD 10_1101-2020_03_27_012757 507 6 Single single JJ 10_1101-2020_03_27_012757 507 7 - - HYPH 10_1101-2020_03_27_012757 507 8 cell cell NN 10_1101-2020_03_27_012757 507 9 classification classification NN 10_1101-2020_03_27_012757 507 10 of of IN 10_1101-2020_03_27_012757 507 11 SKCM SKCM NNP 10_1101-2020_03_27_012757 507 12 and and CC 10_1101-2020_03_27_012757 507 13 GBM GBM NNP 10_1101-2020_03_27_012757 507 14 cell cell NN 10_1101-2020_03_27_012757 507 15 lines line NNS 10_1101-2020_03_27_012757 507 16 . . . 10_1101-2020_03_27_012757 508 1 ( ( -LRB- 10_1101-2020_03_27_012757 508 2 A a NN 10_1101-2020_03_27_012757 508 3 ) ) -RRB- 10_1101-2020_03_27_012757 508 4 AUPRC AUPRC NNS 10_1101-2020_03_27_012757 508 5 of of IN 10_1101-2020_03_27_012757 508 6 944 944 CD 10_1101-2020_03_27_012757 508 7 the the DT 10_1101-2020_03_27_012757 508 8 single single JJ 10_1101-2020_03_27_012757 508 9 - - HYPH 10_1101-2020_03_27_012757 508 10 cell cell NN 10_1101-2020_03_27_012757 508 11 classifier classifier NN 10_1101-2020_03_27_012757 508 12 when when WRB 10_1101-2020_03_27_012757 508 13 applied apply VBN 10_1101-2020_03_27_012757 508 14 to to IN 10_1101-2020_03_27_012757 508 15 scRNA scRNA NNP 10_1101-2020_03_27_012757 508 16 - - HYPH 10_1101-2020_03_27_012757 508 17 seq seq NN 10_1101-2020_03_27_012757 508 18 held hold VBN 10_1101-2020_03_27_012757 508 19 - - HYPH 10_1101-2020_03_27_012757 508 20 out out RP 10_1101-2020_03_27_012757 508 21 data datum NNS 10_1101-2020_03_27_012757 508 22 . . . 10_1101-2020_03_27_012757 509 1 ( ( -LRB- 10_1101-2020_03_27_012757 509 2 B b NN 10_1101-2020_03_27_012757 509 3 ) ) -RRB- 10_1101-2020_03_27_012757 509 4 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 509 5 of of IN 10_1101-2020_03_27_012757 509 6 the the DT 10_1101-2020_03_27_012757 509 7 scRNA-945 scrna-945 NN 10_1101-2020_03_27_012757 509 8 seq seq NN 10_1101-2020_03_27_012757 509 9 classifier classifier NN 10_1101-2020_03_27_012757 509 10 when when WRB 10_1101-2020_03_27_012757 509 11 applied apply VBN 10_1101-2020_03_27_012757 509 12 to to IN 10_1101-2020_03_27_012757 509 13 purified purify VBN 10_1101-2020_03_27_012757 509 14 bulk bulk NNP 10_1101-2020_03_27_012757 509 15 RNA RNA NNP 10_1101-2020_03_27_012757 509 16 samples sample NNS 10_1101-2020_03_27_012757 509 17 . . . 10_1101-2020_03_27_012757 510 1 ( ( -LRB- 10_1101-2020_03_27_012757 510 2 C C NNP 10_1101-2020_03_27_012757 510 3 ) ) -RRB- 10_1101-2020_03_27_012757 510 4 Single single JJ 10_1101-2020_03_27_012757 510 5 - - HYPH 10_1101-2020_03_27_012757 510 6 cell cell NN 10_1101-2020_03_27_012757 510 7 classification classification NN 10_1101-2020_03_27_012757 510 8 of of IN 10_1101-2020_03_27_012757 510 9 SKCM SKCM NNP 10_1101-2020_03_27_012757 510 10 946 946 CD 10_1101-2020_03_27_012757 510 11 CCLs ccl NNS 10_1101-2020_03_27_012757 510 12 . . . 10_1101-2020_03_27_012757 511 1 Red red JJ 10_1101-2020_03_27_012757 511 2 bar bar NN 10_1101-2020_03_27_012757 511 3 - - HYPH 10_1101-2020_03_27_012757 511 4 plot plot NN 10_1101-2020_03_27_012757 511 5 ( ( -LRB- 10_1101-2020_03_27_012757 511 6 top top NN 10_1101-2020_03_27_012757 511 7 ) ) -RRB- 10_1101-2020_03_27_012757 511 8 represents represent VBZ 10_1101-2020_03_27_012757 511 9 general general JJ 10_1101-2020_03_27_012757 511 10 CCN CCN NNP 10_1101-2020_03_27_012757 511 11 scores score NNS 10_1101-2020_03_27_012757 511 12 in in IN 10_1101-2020_03_27_012757 511 13 SARC SARC NNP 10_1101-2020_03_27_012757 511 14 and and CC 10_1101-2020_03_27_012757 511 15 blue blue JJ 10_1101-2020_03_27_012757 511 16 bar bar NN 10_1101-2020_03_27_012757 511 17 - - HYPH 10_1101-2020_03_27_012757 511 18 plot plot NN 10_1101-2020_03_27_012757 511 19 ( ( -LRB- 10_1101-2020_03_27_012757 511 20 bottom bottom NN 10_1101-2020_03_27_012757 511 21 ) ) -RRB- 10_1101-2020_03_27_012757 511 22 947 947 CD 10_1101-2020_03_27_012757 511 23 represents represent VBZ 10_1101-2020_03_27_012757 511 24 general general JJ 10_1101-2020_03_27_012757 511 25 CCN CCN NNP 10_1101-2020_03_27_012757 511 26 scores score NNS 10_1101-2020_03_27_012757 511 27 in in IN 10_1101-2020_03_27_012757 511 28 SKCM SKCM NNP 10_1101-2020_03_27_012757 511 29 . . . 10_1101-2020_03_27_012757 512 1 ( ( -LRB- 10_1101-2020_03_27_012757 512 2 D d NN 10_1101-2020_03_27_012757 512 3 ) ) -RRB- 10_1101-2020_03_27_012757 512 4 Single single JJ 10_1101-2020_03_27_012757 512 5 - - HYPH 10_1101-2020_03_27_012757 512 6 cell cell NN 10_1101-2020_03_27_012757 512 7 classification classification NN 10_1101-2020_03_27_012757 512 8 of of IN 10_1101-2020_03_27_012757 512 9 GBM GBM NNP 10_1101-2020_03_27_012757 512 10 CCLs CCLs NNPS 10_1101-2020_03_27_012757 512 11 . . . 10_1101-2020_03_27_012757 513 1 Red red JJ 10_1101-2020_03_27_012757 513 2 bar-948 bar-948 NNP 10_1101-2020_03_27_012757 513 3 plot plot NN 10_1101-2020_03_27_012757 513 4 ( ( -LRB- 10_1101-2020_03_27_012757 513 5 top top NN 10_1101-2020_03_27_012757 513 6 ) ) -RRB- 10_1101-2020_03_27_012757 513 7 represents represent VBZ 10_1101-2020_03_27_012757 513 8 general general JJ 10_1101-2020_03_27_012757 513 9 CCN CCN NNP 10_1101-2020_03_27_012757 513 10 scores score NNS 10_1101-2020_03_27_012757 513 11 in in IN 10_1101-2020_03_27_012757 513 12 SARC SARC NNP 10_1101-2020_03_27_012757 513 13 and and CC 10_1101-2020_03_27_012757 513 14 yellow yellow JJ 10_1101-2020_03_27_012757 513 15 bar bar NN 10_1101-2020_03_27_012757 513 16 - - HYPH 10_1101-2020_03_27_012757 513 17 plot plot NN 10_1101-2020_03_27_012757 513 18 ( ( -LRB- 10_1101-2020_03_27_012757 513 19 bottom bottom NN 10_1101-2020_03_27_012757 513 20 ) ) -RRB- 10_1101-2020_03_27_012757 513 21 represents represent VBZ 10_1101-2020_03_27_012757 513 22 949 949 CD 10_1101-2020_03_27_012757 513 23 general general JJ 10_1101-2020_03_27_012757 513 24 CCN CCN NNP 10_1101-2020_03_27_012757 513 25 scores score NNS 10_1101-2020_03_27_012757 513 26 in in IN 10_1101-2020_03_27_012757 513 27 GBM GBM NNP 10_1101-2020_03_27_012757 513 28 . . . 10_1101-2020_03_27_012757 514 1 950 950 CD 10_1101-2020_03_27_012757 514 2 951 951 CD 10_1101-2020_03_27_012757 514 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 514 4 Figure figure NN 10_1101-2020_03_27_012757 514 5 4 4 CD 10_1101-2020_03_27_012757 514 6 Correlation correlation NN 10_1101-2020_03_27_012757 514 7 between between IN 10_1101-2020_03_27_012757 514 8 cancer cancer NN 10_1101-2020_03_27_012757 514 9 type type NN 10_1101-2020_03_27_012757 514 10 specific specific JJ 10_1101-2020_03_27_012757 514 11 network network NN 10_1101-2020_03_27_012757 514 12 GRN GRN NNP 10_1101-2020_03_27_012757 514 13 status status NN 10_1101-2020_03_27_012757 514 14 and and CC 10_1101-2020_03_27_012757 514 15 952 952 CD 10_1101-2020_03_27_012757 514 16 general general JJ 10_1101-2020_03_27_012757 514 17 CCN CCN NNP 10_1101-2020_03_27_012757 514 18 scores score NNS 10_1101-2020_03_27_012757 514 19 . . . 10_1101-2020_03_27_012757 515 1 953 953 CD 10_1101-2020_03_27_012757 515 2 954 954 CD 10_1101-2020_03_27_012757 515 3 955 955 CD 10_1101-2020_03_27_012757 515 4 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 515 5 Figure figure NN 10_1101-2020_03_27_012757 515 6 5 5 CD 10_1101-2020_03_27_012757 515 7 Proportion proportion NN 10_1101-2020_03_27_012757 515 8 of of IN 10_1101-2020_03_27_012757 515 9 cancer cancer NN 10_1101-2020_03_27_012757 515 10 subtypes subtype NNS 10_1101-2020_03_27_012757 515 11 in in IN 10_1101-2020_03_27_012757 515 12 different different JJ 10_1101-2020_03_27_012757 515 13 cancer cancer NN 10_1101-2020_03_27_012757 515 14 models model NNS 10_1101-2020_03_27_012757 515 15 and and CC 10_1101-2020_03_27_012757 515 16 TCGA tcga NN 10_1101-2020_03_27_012757 515 17 956 956 CD 10_1101-2020_03_27_012757 515 18 tumor tumor NN 10_1101-2020_03_27_012757 515 19 data datum NNS 10_1101-2020_03_27_012757 515 20 across across IN 10_1101-2020_03_27_012757 515 21 11 11 CD 10_1101-2020_03_27_012757 515 22 general general JJ 10_1101-2020_03_27_012757 515 23 cancer cancer NN 10_1101-2020_03_27_012757 515 24 types type NNS 10_1101-2020_03_27_012757 515 25 . . . 10_1101-2020_03_27_012757 516 1 957 957 CD 10_1101-2020_03_27_012757 516 2 958 958 CD 10_1101-2020_03_27_012757 516 3 .CC .CC : 10_1101-2020_03_27_012757 516 4 - - HYPH 10_1101-2020_03_27_012757 516 5 BY by IN 10_1101-2020_03_27_012757 516 6 - - HYPH 10_1101-2020_03_27_012757 516 7 NC NC NNP 10_1101-2020_03_27_012757 516 8 - - HYPH 10_1101-2020_03_27_012757 516 9 ND ND NNP 10_1101-2020_03_27_012757 516 10 4.0 4.0 CD 10_1101-2020_03_27_012757 516 11 International International NNP 10_1101-2020_03_27_012757 516 12 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 516 13 under under IN 10_1101-2020_03_27_012757 516 14 a a DT 10_1101-2020_03_27_012757 516 15 ( ( -LRB- 10_1101-2020_03_27_012757 516 16 which which WDT 10_1101-2020_03_27_012757 516 17 was be VBD 10_1101-2020_03_27_012757 516 18 not not RB 10_1101-2020_03_27_012757 516 19 certified certify VBN 10_1101-2020_03_27_012757 516 20 by by IN 10_1101-2020_03_27_012757 516 21 peer peer NN 10_1101-2020_03_27_012757 516 22 review review NN 10_1101-2020_03_27_012757 516 23 ) ) -RRB- 10_1101-2020_03_27_012757 516 24 is be VBZ 10_1101-2020_03_27_012757 516 25 the the DT 10_1101-2020_03_27_012757 516 26 author author NN 10_1101-2020_03_27_012757 516 27 / / SYM 10_1101-2020_03_27_012757 516 28 funder funder NN 10_1101-2020_03_27_012757 516 29 , , , 10_1101-2020_03_27_012757 516 30 who who WP 10_1101-2020_03_27_012757 516 31 has have VBZ 10_1101-2020_03_27_012757 516 32 granted grant VBN 10_1101-2020_03_27_012757 516 33 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 516 34 a a DT 10_1101-2020_03_27_012757 516 35 license license NN 10_1101-2020_03_27_012757 516 36 to to TO 10_1101-2020_03_27_012757 516 37 display display VB 10_1101-2020_03_27_012757 516 38 the the DT 10_1101-2020_03_27_012757 516 39 preprint preprint NN 10_1101-2020_03_27_012757 516 40 in in IN 10_1101-2020_03_27_012757 516 41 perpetuity perpetuity NN 10_1101-2020_03_27_012757 516 42 . . . 10_1101-2020_03_27_012757 517 1 It -PRON- PRP 10_1101-2020_03_27_012757 517 2 is be VBZ 10_1101-2020_03_27_012757 517 3 made make VBN 10_1101-2020_03_27_012757 517 4 The the DT 10_1101-2020_03_27_012757 517 5 copyright copyright NN 10_1101-2020_03_27_012757 517 6 holder holder NN 10_1101-2020_03_27_012757 517 7 for for IN 10_1101-2020_03_27_012757 517 8 this this DT 10_1101-2020_03_27_012757 517 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 517 10 version version NN 10_1101-2020_03_27_012757 517 11 posted post VBD 10_1101-2020_03_27_012757 517 12 January January NNP 10_1101-2020_03_27_012757 517 13 9 9 CD 10_1101-2020_03_27_012757 517 14 , , , 10_1101-2020_03_27_012757 517 15 2021 2021 CD 10_1101-2020_03_27_012757 517 16 . . . 10_1101-2020_03_27_012757 517 17 ; ; : 10_1101-2020_03_27_012757 517 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 517 19 : : : 10_1101-2020_03_27_012757 517 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 517 21 preprint preprint NN 10_1101-2020_03_27_012757 517 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 517 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 517 24 37 37 CD 10_1101-2020_03_27_012757 517 25 959 959 CD 10_1101-2020_03_27_012757 517 26 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 517 27 Table table NN 10_1101-2020_03_27_012757 517 28 1 1 CD 10_1101-2020_03_27_012757 517 29 General general JJ 10_1101-2020_03_27_012757 517 30 classification classification NN 10_1101-2020_03_27_012757 517 31 profiles profile NNS 10_1101-2020_03_27_012757 517 32 of of IN 10_1101-2020_03_27_012757 517 33 CCLs ccl NNS 10_1101-2020_03_27_012757 517 34 . . . 10_1101-2020_03_27_012757 518 1 960 960 CD 10_1101-2020_03_27_012757 518 2 961 961 CD 10_1101-2020_03_27_012757 518 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 518 4 Table table NN 10_1101-2020_03_27_012757 518 5 2 2 NNP 10_1101-2020_03_27_012757 518 6 Subtype Subtype NNP 10_1101-2020_03_27_012757 518 7 classification classification NN 10_1101-2020_03_27_012757 518 8 profiles profile NNS 10_1101-2020_03_27_012757 518 9 of of IN 10_1101-2020_03_27_012757 518 10 CCLs ccl NNS 10_1101-2020_03_27_012757 518 11 . . . 10_1101-2020_03_27_012757 519 1 962 962 CD 10_1101-2020_03_27_012757 519 2 963 963 CD 10_1101-2020_03_27_012757 519 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 519 4 Table table NN 10_1101-2020_03_27_012757 519 5 3 3 CD 10_1101-2020_03_27_012757 519 6 General general JJ 10_1101-2020_03_27_012757 519 7 classification classification NN 10_1101-2020_03_27_012757 519 8 profiles profile NNS 10_1101-2020_03_27_012757 519 9 of of IN 10_1101-2020_03_27_012757 519 10 PDXs pdx NNS 10_1101-2020_03_27_012757 519 11 . . . 10_1101-2020_03_27_012757 520 1 964 964 CD 10_1101-2020_03_27_012757 520 2 965 965 CD 10_1101-2020_03_27_012757 520 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 520 4 Table table NN 10_1101-2020_03_27_012757 520 5 4 4 CD 10_1101-2020_03_27_012757 520 6 Subtype Subtype NNP 10_1101-2020_03_27_012757 520 7 classification classification NN 10_1101-2020_03_27_012757 520 8 profiles profile NNS 10_1101-2020_03_27_012757 520 9 of of IN 10_1101-2020_03_27_012757 520 10 PDXs pdx NNS 10_1101-2020_03_27_012757 520 11 . . . 10_1101-2020_03_27_012757 521 1 966 966 CD 10_1101-2020_03_27_012757 521 2 967 967 CD 10_1101-2020_03_27_012757 521 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 521 4 Table table NN 10_1101-2020_03_27_012757 521 5 5 5 CD 10_1101-2020_03_27_012757 521 6 General general JJ 10_1101-2020_03_27_012757 521 7 classification classification NN 10_1101-2020_03_27_012757 521 8 profiles profile NNS 10_1101-2020_03_27_012757 521 9 of of IN 10_1101-2020_03_27_012757 521 10 GEMMs GEMMs NNP 10_1101-2020_03_27_012757 521 11 968 968 CD 10_1101-2020_03_27_012757 521 12 969 969 CD 10_1101-2020_03_27_012757 521 13 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 521 14 Table table NN 10_1101-2020_03_27_012757 521 15 6 6 CD 10_1101-2020_03_27_012757 521 16 Subtype Subtype NNP 10_1101-2020_03_27_012757 521 17 classification classification NN 10_1101-2020_03_27_012757 521 18 profiles profile NNS 10_1101-2020_03_27_012757 521 19 of of IN 10_1101-2020_03_27_012757 521 20 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 521 21 . . . 10_1101-2020_03_27_012757 522 1 970 970 CD 10_1101-2020_03_27_012757 522 2 971 971 CD 10_1101-2020_03_27_012757 522 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 522 4 Table table NN 10_1101-2020_03_27_012757 522 5 7 7 CD 10_1101-2020_03_27_012757 522 6 General General NNP 10_1101-2020_03_27_012757 522 7 classification classification NN 10_1101-2020_03_27_012757 522 8 profiles profile NNS 10_1101-2020_03_27_012757 522 9 of of IN 10_1101-2020_03_27_012757 522 10 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 522 11 . . . 10_1101-2020_03_27_012757 523 1 972 972 CD 10_1101-2020_03_27_012757 523 2 973 973 CD 10_1101-2020_03_27_012757 523 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 523 4 Table Table NNP 10_1101-2020_03_27_012757 523 5 8 8 CD 10_1101-2020_03_27_012757 523 6 Subtype Subtype NNP 10_1101-2020_03_27_012757 523 7 classification classification NN 10_1101-2020_03_27_012757 523 8 profiles profile NNS 10_1101-2020_03_27_012757 523 9 of of IN 10_1101-2020_03_27_012757 523 10 tumoroids tumoroid NNS 10_1101-2020_03_27_012757 523 11 . . . 10_1101-2020_03_27_012757 524 1 974 974 CD 10_1101-2020_03_27_012757 524 2 975 975 CD 10_1101-2020_03_27_012757 524 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 524 4 Table table NN 10_1101-2020_03_27_012757 524 5 9 9 CD 10_1101-2020_03_27_012757 524 6 Specific specific JJ 10_1101-2020_03_27_012757 524 7 parameters parameter NNS 10_1101-2020_03_27_012757 524 8 used use VBN 10_1101-2020_03_27_012757 524 9 for for IN 10_1101-2020_03_27_012757 524 10 training training NN 10_1101-2020_03_27_012757 524 11 of of IN 10_1101-2020_03_27_012757 524 12 all all DT 10_1101-2020_03_27_012757 524 13 classifiers classifier NNS 10_1101-2020_03_27_012757 524 14 . . . 10_1101-2020_03_27_012757 525 1 976 976 CD 10_1101-2020_03_27_012757 525 2 977 977 CD 10_1101-2020_03_27_012757 525 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 525 4 Table table NN 10_1101-2020_03_27_012757 525 5 10 10 CD 10_1101-2020_03_27_012757 525 6 Gene Gene NNP 10_1101-2020_03_27_012757 525 7 - - HYPH 10_1101-2020_03_27_012757 525 8 pairs pairs NNP 10_1101-2020_03_27_012757 525 9 selected select VBN 10_1101-2020_03_27_012757 525 10 for for IN 10_1101-2020_03_27_012757 525 11 final final JJ 10_1101-2020_03_27_012757 525 12 training training NN 10_1101-2020_03_27_012757 525 13 of of IN 10_1101-2020_03_27_012757 525 14 CCN CCN NNP 10_1101-2020_03_27_012757 525 15 general general JJ 10_1101-2020_03_27_012757 525 16 , , , 10_1101-2020_03_27_012757 525 17 subtype subtype NN 10_1101-2020_03_27_012757 525 18 978 978 CD 10_1101-2020_03_27_012757 525 19 classifiers classifier NNS 10_1101-2020_03_27_012757 525 20 and and CC 10_1101-2020_03_27_012757 525 21 single single JJ 10_1101-2020_03_27_012757 525 22 - - HYPH 10_1101-2020_03_27_012757 525 23 cell cell NN 10_1101-2020_03_27_012757 525 24 classifier classifier NN 10_1101-2020_03_27_012757 525 25 . . . 10_1101-2020_03_27_012757 526 1 979 979 CD 10_1101-2020_03_27_012757 526 2 980 980 CD 10_1101-2020_03_27_012757 526 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 526 4 Table table NN 10_1101-2020_03_27_012757 526 5 11 11 CD 10_1101-2020_03_27_012757 526 6 Decision Decision NNP 10_1101-2020_03_27_012757 526 7 thresholds threshold NNS 10_1101-2020_03_27_012757 526 8 and and CC 10_1101-2020_03_27_012757 526 9 the the DT 10_1101-2020_03_27_012757 526 10 corresponding corresponding JJ 10_1101-2020_03_27_012757 526 11 precision precision NN 10_1101-2020_03_27_012757 526 12 and and CC 10_1101-2020_03_27_012757 526 13 recall recall NN 10_1101-2020_03_27_012757 526 14 for for IN 10_1101-2020_03_27_012757 526 15 981 981 CD 10_1101-2020_03_27_012757 526 16 the the DT 10_1101-2020_03_27_012757 526 17 general general JJ 10_1101-2020_03_27_012757 526 18 classifier classifier NN 10_1101-2020_03_27_012757 526 19 and and CC 10_1101-2020_03_27_012757 526 20 subtype subtype NN 10_1101-2020_03_27_012757 526 21 classifier classifier NN 10_1101-2020_03_27_012757 526 22 . . . 10_1101-2020_03_27_012757 527 1 982 982 CD 10_1101-2020_03_27_012757 527 2 983 983 CD 10_1101-2020_03_27_012757 527 3 Supplementary Supplementary NNP 10_1101-2020_03_27_012757 527 4 Table table NN 10_1101-2020_03_27_012757 527 5 12 12 CD 10_1101-2020_03_27_012757 527 6 Accessions accession NNS 10_1101-2020_03_27_012757 527 7 of of IN 10_1101-2020_03_27_012757 527 8 tumor tumor NN 10_1101-2020_03_27_012757 527 9 microarray microarray JJ 10_1101-2020_03_27_012757 527 10 data datum NNS 10_1101-2020_03_27_012757 527 11 used use VBN 10_1101-2020_03_27_012757 527 12 in in IN 10_1101-2020_03_27_012757 527 13 validation validation NN 10_1101-2020_03_27_012757 527 14 . . . 10_1101-2020_03_27_012757 528 1 984 984 CD 10_1101-2020_03_27_012757 528 2 985 985 CD 10_1101-2020_03_27_012757 528 3 986 986 CD 10_1101-2020_03_27_012757 528 4 REFERENCES reference NNS 10_1101-2020_03_27_012757 528 5 987 987 CD 10_1101-2020_03_27_012757 528 6 1 1 CD 10_1101-2020_03_27_012757 528 7 . . . 10_1101-2020_03_27_012757 529 1 Sharma Sharma NNP 10_1101-2020_03_27_012757 529 2 , , , 10_1101-2020_03_27_012757 529 3 S. S. NNP 10_1101-2020_03_27_012757 529 4 V. V. NNP 10_1101-2020_03_27_012757 529 5 , , , 10_1101-2020_03_27_012757 529 6 Haber Haber NNP 10_1101-2020_03_27_012757 529 7 , , , 10_1101-2020_03_27_012757 529 8 D. D. NNP 10_1101-2020_03_27_012757 529 9 A. A. NNP 10_1101-2020_03_27_012757 530 1 & & CC 10_1101-2020_03_27_012757 530 2 Settleman Settleman NNP 10_1101-2020_03_27_012757 530 3 , , , 10_1101-2020_03_27_012757 530 4 J. J. NNP 10_1101-2020_03_27_012757 531 1 Cell cell NN 10_1101-2020_03_27_012757 531 2 line line NN 10_1101-2020_03_27_012757 531 3 - - HYPH 10_1101-2020_03_27_012757 531 4 based base VBN 10_1101-2020_03_27_012757 531 5 platforms platform NNS 10_1101-2020_03_27_012757 531 6 to to TO 10_1101-2020_03_27_012757 531 7 evaluate evaluate VB 10_1101-2020_03_27_012757 531 8 988 988 CD 10_1101-2020_03_27_012757 531 9 the the DT 10_1101-2020_03_27_012757 531 10 therapeutic therapeutic JJ 10_1101-2020_03_27_012757 531 11 efficacy efficacy NN 10_1101-2020_03_27_012757 531 12 of of IN 10_1101-2020_03_27_012757 531 13 candidate candidate NN 10_1101-2020_03_27_012757 531 14 anticancer anticancer NN 10_1101-2020_03_27_012757 531 15 agents agent NNS 10_1101-2020_03_27_012757 531 16 . . . 10_1101-2020_03_27_012757 532 1 Nat Nat NNP 10_1101-2020_03_27_012757 532 2 . . . 10_1101-2020_03_27_012757 533 1 Rev. Rev. NNP 10_1101-2020_03_27_012757 534 1 Cancer cancer NN 10_1101-2020_03_27_012757 534 2 10 10 CD 10_1101-2020_03_27_012757 534 3 , , , 10_1101-2020_03_27_012757 534 4 241–989 241–989 CD 10_1101-2020_03_27_012757 534 5 253 253 CD 10_1101-2020_03_27_012757 534 6 ( ( -LRB- 10_1101-2020_03_27_012757 534 7 2010 2010 CD 10_1101-2020_03_27_012757 534 8 ) ) -RRB- 10_1101-2020_03_27_012757 534 9 . . . 10_1101-2020_03_27_012757 535 1 990 990 CD 10_1101-2020_03_27_012757 535 2 2 2 CD 10_1101-2020_03_27_012757 535 3 . . . 10_1101-2020_03_27_012757 536 1 Kersten Kersten NNP 10_1101-2020_03_27_012757 536 2 , , , 10_1101-2020_03_27_012757 536 3 K. K. NNP 10_1101-2020_03_27_012757 536 4 , , , 10_1101-2020_03_27_012757 536 5 de de NNP 10_1101-2020_03_27_012757 536 6 Visser Visser NNP 10_1101-2020_03_27_012757 536 7 , , , 10_1101-2020_03_27_012757 536 8 K. K. NNP 10_1101-2020_03_27_012757 536 9 E. E. NNP 10_1101-2020_03_27_012757 536 10 , , , 10_1101-2020_03_27_012757 536 11 van van NNP 10_1101-2020_03_27_012757 536 12 Miltenburg Miltenburg NNP 10_1101-2020_03_27_012757 536 13 , , , 10_1101-2020_03_27_012757 536 14 M. M. NNP 10_1101-2020_03_27_012757 536 15 H. H. NNP 10_1101-2020_03_27_012757 536 16 & & CC 10_1101-2020_03_27_012757 536 17 Jonkers Jonkers NNP 10_1101-2020_03_27_012757 536 18 , , , 10_1101-2020_03_27_012757 536 19 J. J. NNP 10_1101-2020_03_27_012757 537 1 Genetically genetically RB 10_1101-2020_03_27_012757 537 2 991 991 CD 10_1101-2020_03_27_012757 537 3 engineered engineer VBN 10_1101-2020_03_27_012757 537 4 mouse mouse NN 10_1101-2020_03_27_012757 537 5 models model NNS 10_1101-2020_03_27_012757 537 6 in in IN 10_1101-2020_03_27_012757 537 7 oncology oncology NN 10_1101-2020_03_27_012757 537 8 research research NN 10_1101-2020_03_27_012757 537 9 and and CC 10_1101-2020_03_27_012757 537 10 cancer cancer NN 10_1101-2020_03_27_012757 537 11 medicine medicine NN 10_1101-2020_03_27_012757 537 12 . . . 10_1101-2020_03_27_012757 538 1 EMBO EMBO NNP 10_1101-2020_03_27_012757 538 2 Mol Mol NNP 10_1101-2020_03_27_012757 538 3 . . . 10_1101-2020_03_27_012757 539 1 992 992 CD 10_1101-2020_03_27_012757 539 2 Med Med NNP 10_1101-2020_03_27_012757 539 3 . . . 10_1101-2020_03_27_012757 540 1 9 9 CD 10_1101-2020_03_27_012757 540 2 , , , 10_1101-2020_03_27_012757 540 3 137–153 137–153 CD 10_1101-2020_03_27_012757 540 4 ( ( -LRB- 10_1101-2020_03_27_012757 540 5 2017 2017 CD 10_1101-2020_03_27_012757 540 6 ) ) -RRB- 10_1101-2020_03_27_012757 540 7 . . . 10_1101-2020_03_27_012757 541 1 993 993 CD 10_1101-2020_03_27_012757 541 2 3 3 CD 10_1101-2020_03_27_012757 541 3 . . . 10_1101-2020_03_27_012757 542 1 Hidalgo Hidalgo NNP 10_1101-2020_03_27_012757 542 2 , , , 10_1101-2020_03_27_012757 542 3 M. M. NNP 10_1101-2020_03_27_012757 542 4 et et NNP 10_1101-2020_03_27_012757 542 5 al al NNP 10_1101-2020_03_27_012757 542 6 . . . 10_1101-2020_03_27_012757 543 1 Patient patient NN 10_1101-2020_03_27_012757 543 2 - - HYPH 10_1101-2020_03_27_012757 543 3 derived derive VBN 10_1101-2020_03_27_012757 543 4 xenograft xenograft NN 10_1101-2020_03_27_012757 543 5 models model NNS 10_1101-2020_03_27_012757 543 6 : : : 10_1101-2020_03_27_012757 543 7 an an DT 10_1101-2020_03_27_012757 543 8 emerging emerge VBG 10_1101-2020_03_27_012757 543 9 platform platform NN 10_1101-2020_03_27_012757 543 10 for for IN 10_1101-2020_03_27_012757 543 11 994 994 CD 10_1101-2020_03_27_012757 543 12 translational translational JJ 10_1101-2020_03_27_012757 543 13 cancer cancer NN 10_1101-2020_03_27_012757 543 14 research research NN 10_1101-2020_03_27_012757 543 15 . . . 10_1101-2020_03_27_012757 544 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 544 2 Discov Discov NNP 10_1101-2020_03_27_012757 544 3 . . . 10_1101-2020_03_27_012757 545 1 4 4 LS 10_1101-2020_03_27_012757 545 2 , , , 10_1101-2020_03_27_012757 545 3 998–1013 998–1013 CD 10_1101-2020_03_27_012757 545 4 ( ( -LRB- 10_1101-2020_03_27_012757 545 5 2014 2014 CD 10_1101-2020_03_27_012757 545 6 ) ) -RRB- 10_1101-2020_03_27_012757 545 7 . . . 10_1101-2020_03_27_012757 546 1 995 995 CD 10_1101-2020_03_27_012757 546 2 4 4 CD 10_1101-2020_03_27_012757 546 3 . . . 10_1101-2020_03_27_012757 547 1 Drost drost UH 10_1101-2020_03_27_012757 547 2 , , , 10_1101-2020_03_27_012757 547 3 J. J. NNP 10_1101-2020_03_27_012757 548 1 & & CC 10_1101-2020_03_27_012757 548 2 Clevers Clevers NNP 10_1101-2020_03_27_012757 548 3 , , , 10_1101-2020_03_27_012757 548 4 H. H. NNP 10_1101-2020_03_27_012757 548 5 Organoids Organoids NNP 10_1101-2020_03_27_012757 548 6 in in IN 10_1101-2020_03_27_012757 548 7 cancer cancer NN 10_1101-2020_03_27_012757 548 8 research research NN 10_1101-2020_03_27_012757 548 9 . . . 10_1101-2020_03_27_012757 549 1 Nat Nat NNP 10_1101-2020_03_27_012757 549 2 . . . 10_1101-2020_03_27_012757 550 1 Rev. Rev. NNP 10_1101-2020_03_27_012757 551 1 Cancer cancer NN 10_1101-2020_03_27_012757 551 2 18 18 CD 10_1101-2020_03_27_012757 551 3 , , , 10_1101-2020_03_27_012757 551 4 407–996 407–996 CD 10_1101-2020_03_27_012757 551 5 418 418 CD 10_1101-2020_03_27_012757 551 6 ( ( -LRB- 10_1101-2020_03_27_012757 551 7 2018 2018 CD 10_1101-2020_03_27_012757 551 8 ) ) -RRB- 10_1101-2020_03_27_012757 551 9 . . . 10_1101-2020_03_27_012757 552 1 997 997 CD 10_1101-2020_03_27_012757 552 2 5 5 CD 10_1101-2020_03_27_012757 552 3 . . . 10_1101-2020_03_27_012757 553 1 Klijn Klijn NNP 10_1101-2020_03_27_012757 553 2 , , , 10_1101-2020_03_27_012757 553 3 C. C. NNP 10_1101-2020_03_27_012757 553 4 et et NNP 10_1101-2020_03_27_012757 553 5 al al NNP 10_1101-2020_03_27_012757 553 6 . . . 10_1101-2020_03_27_012757 554 1 A a DT 10_1101-2020_03_27_012757 554 2 comprehensive comprehensive JJ 10_1101-2020_03_27_012757 554 3 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 554 4 portrait portrait NN 10_1101-2020_03_27_012757 554 5 of of IN 10_1101-2020_03_27_012757 554 6 human human JJ 10_1101-2020_03_27_012757 554 7 cancer cancer NN 10_1101-2020_03_27_012757 554 8 cell cell NN 10_1101-2020_03_27_012757 554 9 lines line NNS 10_1101-2020_03_27_012757 554 10 . . . 10_1101-2020_03_27_012757 555 1 998 998 CD 10_1101-2020_03_27_012757 555 2 Nat Nat NNP 10_1101-2020_03_27_012757 555 3 . . . 10_1101-2020_03_27_012757 556 1 Biotechnol Biotechnol NNS 10_1101-2020_03_27_012757 556 2 . . . 10_1101-2020_03_27_012757 557 1 33 33 CD 10_1101-2020_03_27_012757 557 2 , , , 10_1101-2020_03_27_012757 557 3 306–312 306–312 CD 10_1101-2020_03_27_012757 557 4 ( ( -LRB- 10_1101-2020_03_27_012757 557 5 2015 2015 CD 10_1101-2020_03_27_012757 557 6 ) ) -RRB- 10_1101-2020_03_27_012757 557 7 . . . 10_1101-2020_03_27_012757 558 1 999 999 CD 10_1101-2020_03_27_012757 558 2 6 6 CD 10_1101-2020_03_27_012757 558 3 . . . 10_1101-2020_03_27_012757 559 1 Koren Koren NNP 10_1101-2020_03_27_012757 559 2 , , , 10_1101-2020_03_27_012757 559 3 S. S. NNP 10_1101-2020_03_27_012757 559 4 et et NNP 10_1101-2020_03_27_012757 559 5 al al NNP 10_1101-2020_03_27_012757 559 6 . . . 10_1101-2020_03_27_012757 560 1 PIK3CA(H1047R PIK3CA(H1047R NNP 10_1101-2020_03_27_012757 560 2 ) ) -RRB- 10_1101-2020_03_27_012757 560 3 induces induce VBZ 10_1101-2020_03_27_012757 560 4 multipotency multipotency NNP 10_1101-2020_03_27_012757 560 5 and and CC 10_1101-2020_03_27_012757 560 6 multi multi JJ 10_1101-2020_03_27_012757 560 7 - - JJ 10_1101-2020_03_27_012757 560 8 lineage lineage JJ 10_1101-2020_03_27_012757 560 9 mammary mammary JJ 10_1101-2020_03_27_012757 560 10 1000 1000 CD 10_1101-2020_03_27_012757 560 11 tumours tumour NNS 10_1101-2020_03_27_012757 560 12 . . . 10_1101-2020_03_27_012757 561 1 Nature nature NN 10_1101-2020_03_27_012757 561 2 525 525 CD 10_1101-2020_03_27_012757 561 3 , , , 10_1101-2020_03_27_012757 561 4 114–118 114–118 CD 10_1101-2020_03_27_012757 561 5 ( ( -LRB- 10_1101-2020_03_27_012757 561 6 2015 2015 CD 10_1101-2020_03_27_012757 561 7 ) ) -RRB- 10_1101-2020_03_27_012757 561 8 . . . 10_1101-2020_03_27_012757 562 1 1001 1001 CD 10_1101-2020_03_27_012757 562 2 7 7 CD 10_1101-2020_03_27_012757 562 3 . . . 10_1101-2020_03_27_012757 563 1 DeRose DeRose NNP 10_1101-2020_03_27_012757 563 2 , , , 10_1101-2020_03_27_012757 563 3 Y. Y. NNP 10_1101-2020_03_27_012757 563 4 S. S. NNP 10_1101-2020_03_27_012757 563 5 et et NNP 10_1101-2020_03_27_012757 563 6 al al NNP 10_1101-2020_03_27_012757 563 7 . . . 10_1101-2020_03_27_012757 564 1 Tumor tumor NN 10_1101-2020_03_27_012757 564 2 grafts graft NNS 10_1101-2020_03_27_012757 564 3 derived derive VBN 10_1101-2020_03_27_012757 564 4 from from IN 10_1101-2020_03_27_012757 564 5 women woman NNS 10_1101-2020_03_27_012757 564 6 with with IN 10_1101-2020_03_27_012757 564 7 breast breast NN 10_1101-2020_03_27_012757 564 8 cancer cancer NN 10_1101-2020_03_27_012757 564 9 1002 1002 CD 10_1101-2020_03_27_012757 564 10 authentically authentically RB 10_1101-2020_03_27_012757 564 11 reflect reflect VBP 10_1101-2020_03_27_012757 564 12 tumor tumor NN 10_1101-2020_03_27_012757 564 13 pathology pathology NN 10_1101-2020_03_27_012757 564 14 , , , 10_1101-2020_03_27_012757 564 15 growth growth NN 10_1101-2020_03_27_012757 564 16 , , , 10_1101-2020_03_27_012757 564 17 metastasis metastasis NN 10_1101-2020_03_27_012757 564 18 and and CC 10_1101-2020_03_27_012757 564 19 disease disease NN 10_1101-2020_03_27_012757 564 20 outcomes outcome NNS 10_1101-2020_03_27_012757 564 21 . . . 10_1101-2020_03_27_012757 565 1 1003 1003 CD 10_1101-2020_03_27_012757 565 2 Nat Nat NNP 10_1101-2020_03_27_012757 565 3 . . . 10_1101-2020_03_27_012757 566 1 Med Med NNP 10_1101-2020_03_27_012757 566 2 . . . 10_1101-2020_03_27_012757 567 1 17 17 CD 10_1101-2020_03_27_012757 567 2 , , , 10_1101-2020_03_27_012757 567 3 1514–1520 1514–1520 CD 10_1101-2020_03_27_012757 567 4 ( ( -LRB- 10_1101-2020_03_27_012757 567 5 2011 2011 CD 10_1101-2020_03_27_012757 567 6 ) ) -RRB- 10_1101-2020_03_27_012757 567 7 . . . 10_1101-2020_03_27_012757 568 1 1004 1004 CD 10_1101-2020_03_27_012757 568 2 .CC .CC : 10_1101-2020_03_27_012757 568 3 - - : 10_1101-2020_03_27_012757 568 4 BY by IN 10_1101-2020_03_27_012757 568 5 - - HYPH 10_1101-2020_03_27_012757 568 6 NC NC NNP 10_1101-2020_03_27_012757 568 7 - - HYPH 10_1101-2020_03_27_012757 568 8 ND ND NNP 10_1101-2020_03_27_012757 568 9 4.0 4.0 CD 10_1101-2020_03_27_012757 568 10 International International NNP 10_1101-2020_03_27_012757 568 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 568 12 under under IN 10_1101-2020_03_27_012757 568 13 a a DT 10_1101-2020_03_27_012757 568 14 ( ( -LRB- 10_1101-2020_03_27_012757 568 15 which which WDT 10_1101-2020_03_27_012757 568 16 was be VBD 10_1101-2020_03_27_012757 568 17 not not RB 10_1101-2020_03_27_012757 568 18 certified certify VBN 10_1101-2020_03_27_012757 568 19 by by IN 10_1101-2020_03_27_012757 568 20 peer peer NN 10_1101-2020_03_27_012757 568 21 review review NN 10_1101-2020_03_27_012757 568 22 ) ) -RRB- 10_1101-2020_03_27_012757 568 23 is be VBZ 10_1101-2020_03_27_012757 568 24 the the DT 10_1101-2020_03_27_012757 568 25 author author NN 10_1101-2020_03_27_012757 568 26 / / SYM 10_1101-2020_03_27_012757 568 27 funder funder NN 10_1101-2020_03_27_012757 568 28 , , , 10_1101-2020_03_27_012757 568 29 who who WP 10_1101-2020_03_27_012757 568 30 has have VBZ 10_1101-2020_03_27_012757 568 31 granted grant VBN 10_1101-2020_03_27_012757 568 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 568 33 a a DT 10_1101-2020_03_27_012757 568 34 license license NN 10_1101-2020_03_27_012757 568 35 to to TO 10_1101-2020_03_27_012757 568 36 display display VB 10_1101-2020_03_27_012757 568 37 the the DT 10_1101-2020_03_27_012757 568 38 preprint preprint NN 10_1101-2020_03_27_012757 568 39 in in IN 10_1101-2020_03_27_012757 568 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 568 41 . . . 10_1101-2020_03_27_012757 569 1 It -PRON- PRP 10_1101-2020_03_27_012757 569 2 is be VBZ 10_1101-2020_03_27_012757 569 3 made make VBN 10_1101-2020_03_27_012757 569 4 The the DT 10_1101-2020_03_27_012757 569 5 copyright copyright NN 10_1101-2020_03_27_012757 569 6 holder holder NN 10_1101-2020_03_27_012757 569 7 for for IN 10_1101-2020_03_27_012757 569 8 this this DT 10_1101-2020_03_27_012757 569 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 569 10 version version NN 10_1101-2020_03_27_012757 569 11 posted post VBD 10_1101-2020_03_27_012757 569 12 January January NNP 10_1101-2020_03_27_012757 569 13 9 9 CD 10_1101-2020_03_27_012757 569 14 , , , 10_1101-2020_03_27_012757 569 15 2021 2021 CD 10_1101-2020_03_27_012757 569 16 . . . 10_1101-2020_03_27_012757 569 17 ; ; : 10_1101-2020_03_27_012757 569 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 569 19 : : : 10_1101-2020_03_27_012757 569 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 569 21 preprint preprint NN 10_1101-2020_03_27_012757 569 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 569 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 569 24 38 38 CD 10_1101-2020_03_27_012757 569 25 8 8 CD 10_1101-2020_03_27_012757 569 26 . . . 10_1101-2020_03_27_012757 570 1 Sharpless Sharpless NNP 10_1101-2020_03_27_012757 570 2 , , , 10_1101-2020_03_27_012757 570 3 N. N. NNP 10_1101-2020_03_27_012757 570 4 E. E. NNP 10_1101-2020_03_27_012757 570 5 & & CC 10_1101-2020_03_27_012757 570 6 Depinho Depinho NNP 10_1101-2020_03_27_012757 570 7 , , , 10_1101-2020_03_27_012757 570 8 R. R. NNP 10_1101-2020_03_27_012757 570 9 A. A. NNP 10_1101-2020_03_27_012757 571 1 The the DT 10_1101-2020_03_27_012757 571 2 mighty mighty JJ 10_1101-2020_03_27_012757 571 3 mouse mouse NN 10_1101-2020_03_27_012757 571 4 : : : 10_1101-2020_03_27_012757 571 5 genetically genetically RB 10_1101-2020_03_27_012757 571 6 engineered engineer VBN 10_1101-2020_03_27_012757 571 7 1005 1005 CD 10_1101-2020_03_27_012757 571 8 mouse mouse NN 10_1101-2020_03_27_012757 571 9 models model NNS 10_1101-2020_03_27_012757 571 10 in in IN 10_1101-2020_03_27_012757 571 11 cancer cancer NN 10_1101-2020_03_27_012757 571 12 drug drug NN 10_1101-2020_03_27_012757 571 13 development development NN 10_1101-2020_03_27_012757 571 14 . . . 10_1101-2020_03_27_012757 572 1 Nat Nat NNP 10_1101-2020_03_27_012757 572 2 . . . 10_1101-2020_03_27_012757 573 1 Rev. Rev. NNP 10_1101-2020_03_27_012757 574 1 Drug Drug NNP 10_1101-2020_03_27_012757 574 2 Discov Discov NNP 10_1101-2020_03_27_012757 574 3 . . . 10_1101-2020_03_27_012757 575 1 5 5 CD 10_1101-2020_03_27_012757 575 2 , , , 10_1101-2020_03_27_012757 575 3 741–754 741–754 CD 10_1101-2020_03_27_012757 575 4 1006 1006 CD 10_1101-2020_03_27_012757 575 5 ( ( -LRB- 10_1101-2020_03_27_012757 575 6 2006 2006 CD 10_1101-2020_03_27_012757 575 7 ) ) -RRB- 10_1101-2020_03_27_012757 575 8 . . . 10_1101-2020_03_27_012757 576 1 1007 1007 CD 10_1101-2020_03_27_012757 576 2 9 9 CD 10_1101-2020_03_27_012757 576 3 . . . 10_1101-2020_03_27_012757 577 1 Mouradov Mouradov NNP 10_1101-2020_03_27_012757 577 2 , , , 10_1101-2020_03_27_012757 577 3 D. D. NNP 10_1101-2020_03_27_012757 577 4 et et NNP 10_1101-2020_03_27_012757 577 5 al al NNP 10_1101-2020_03_27_012757 577 6 . . . 10_1101-2020_03_27_012757 578 1 Colorectal colorectal JJ 10_1101-2020_03_27_012757 578 2 cancer cancer NN 10_1101-2020_03_27_012757 578 3 cell cell NN 10_1101-2020_03_27_012757 578 4 lines line NNS 10_1101-2020_03_27_012757 578 5 are be VBP 10_1101-2020_03_27_012757 578 6 representative representative JJ 10_1101-2020_03_27_012757 578 7 models model NNS 10_1101-2020_03_27_012757 578 8 of of IN 10_1101-2020_03_27_012757 578 9 the the DT 10_1101-2020_03_27_012757 578 10 1008 1008 CD 10_1101-2020_03_27_012757 578 11 main main JJ 10_1101-2020_03_27_012757 578 12 molecular molecular JJ 10_1101-2020_03_27_012757 578 13 subtypes subtype NNS 10_1101-2020_03_27_012757 578 14 of of IN 10_1101-2020_03_27_012757 578 15 primary primary JJ 10_1101-2020_03_27_012757 578 16 cancer cancer NN 10_1101-2020_03_27_012757 578 17 . . . 10_1101-2020_03_27_012757 579 1 Cancer cancer NN 10_1101-2020_03_27_012757 579 2 Res Res NNP 10_1101-2020_03_27_012757 579 3 . . . 10_1101-2020_03_27_012757 580 1 74 74 CD 10_1101-2020_03_27_012757 580 2 , , , 10_1101-2020_03_27_012757 580 3 3238–3247 3238–3247 CD 10_1101-2020_03_27_012757 580 4 ( ( -LRB- 10_1101-2020_03_27_012757 580 5 2014 2014 CD 10_1101-2020_03_27_012757 580 6 ) ) -RRB- 10_1101-2020_03_27_012757 580 7 . . . 10_1101-2020_03_27_012757 581 1 1009 1009 CD 10_1101-2020_03_27_012757 581 2 10 10 CD 10_1101-2020_03_27_012757 581 3 . . . 10_1101-2020_03_27_012757 582 1 Stuckelberger Stuckelberger NNP 10_1101-2020_03_27_012757 582 2 , , , 10_1101-2020_03_27_012757 582 3 S. S. NNP 10_1101-2020_03_27_012757 582 4 & & CC 10_1101-2020_03_27_012757 582 5 Drapkin Drapkin NNP 10_1101-2020_03_27_012757 582 6 , , , 10_1101-2020_03_27_012757 582 7 R. R. NNP 10_1101-2020_03_27_012757 582 8 Precious Precious NNP 10_1101-2020_03_27_012757 582 9 GEMMs GEMMs NNPS 10_1101-2020_03_27_012757 582 10 : : : 10_1101-2020_03_27_012757 582 11 emergence emergence NN 10_1101-2020_03_27_012757 582 12 of of IN 10_1101-2020_03_27_012757 582 13 faithful faithful JJ 10_1101-2020_03_27_012757 582 14 models model NNS 10_1101-2020_03_27_012757 582 15 for for IN 10_1101-2020_03_27_012757 582 16 1010 1010 CD 10_1101-2020_03_27_012757 582 17 ovarian ovarian JJ 10_1101-2020_03_27_012757 582 18 cancer cancer NN 10_1101-2020_03_27_012757 582 19 research research NN 10_1101-2020_03_27_012757 582 20 . . . 10_1101-2020_03_27_012757 583 1 J. J. NNP 10_1101-2020_03_27_012757 583 2 Pathol Pathol NNP 10_1101-2020_03_27_012757 583 3 . . . 10_1101-2020_03_27_012757 584 1 245 245 CD 10_1101-2020_03_27_012757 584 2 , , , 10_1101-2020_03_27_012757 584 3 129–131 129–131 CD 10_1101-2020_03_27_012757 584 4 ( ( -LRB- 10_1101-2020_03_27_012757 584 5 2018 2018 CD 10_1101-2020_03_27_012757 584 6 ) ) -RRB- 10_1101-2020_03_27_012757 584 7 . . . 10_1101-2020_03_27_012757 585 1 1011 1011 CD 10_1101-2020_03_27_012757 585 2 11 11 CD 10_1101-2020_03_27_012757 585 3 . . . 10_1101-2020_03_27_012757 586 1 Domcke Domcke NNP 10_1101-2020_03_27_012757 586 2 , , , 10_1101-2020_03_27_012757 586 3 S. S. NNP 10_1101-2020_03_27_012757 586 4 , , , 10_1101-2020_03_27_012757 586 5 Sinha Sinha NNP 10_1101-2020_03_27_012757 586 6 , , , 10_1101-2020_03_27_012757 586 7 R. R. NNP 10_1101-2020_03_27_012757 586 8 , , , 10_1101-2020_03_27_012757 586 9 Levine Levine NNP 10_1101-2020_03_27_012757 586 10 , , , 10_1101-2020_03_27_012757 586 11 D. D. NNP 10_1101-2020_03_27_012757 586 12 A. A. NNP 10_1101-2020_03_27_012757 586 13 , , , 10_1101-2020_03_27_012757 586 14 Sander Sander NNP 10_1101-2020_03_27_012757 586 15 , , , 10_1101-2020_03_27_012757 586 16 C. C. NNP 10_1101-2020_03_27_012757 586 17 & & CC 10_1101-2020_03_27_012757 586 18 Schultz Schultz NNP 10_1101-2020_03_27_012757 586 19 , , , 10_1101-2020_03_27_012757 586 20 N. N. NNP 10_1101-2020_03_27_012757 586 21 Evaluating evaluate VBG 10_1101-2020_03_27_012757 586 22 cell cell NN 10_1101-2020_03_27_012757 586 23 lines line NNS 10_1101-2020_03_27_012757 586 24 1012 1012 CD 10_1101-2020_03_27_012757 586 25 as as IN 10_1101-2020_03_27_012757 586 26 tumour tumour NN 10_1101-2020_03_27_012757 586 27 models model NNS 10_1101-2020_03_27_012757 586 28 by by IN 10_1101-2020_03_27_012757 586 29 comparison comparison NN 10_1101-2020_03_27_012757 586 30 of of IN 10_1101-2020_03_27_012757 586 31 genomic genomic NNP 10_1101-2020_03_27_012757 586 32 profiles profile NNS 10_1101-2020_03_27_012757 586 33 . . . 10_1101-2020_03_27_012757 587 1 Nat Nat NNP 10_1101-2020_03_27_012757 587 2 . . . 10_1101-2020_03_27_012757 588 1 Commun Commun VBN 10_1101-2020_03_27_012757 588 2 . . . 10_1101-2020_03_27_012757 589 1 4 4 CD 10_1101-2020_03_27_012757 589 2 , , , 10_1101-2020_03_27_012757 589 3 2126 2126 CD 10_1101-2020_03_27_012757 589 4 1013 1013 CD 10_1101-2020_03_27_012757 589 5 ( ( -LRB- 10_1101-2020_03_27_012757 589 6 2013 2013 CD 10_1101-2020_03_27_012757 589 7 ) ) -RRB- 10_1101-2020_03_27_012757 589 8 . . . 10_1101-2020_03_27_012757 590 1 1014 1014 CD 10_1101-2020_03_27_012757 590 2 12 12 CD 10_1101-2020_03_27_012757 590 3 . . . 10_1101-2020_03_27_012757 591 1 Jiang Jiang NNP 10_1101-2020_03_27_012757 591 2 , , , 10_1101-2020_03_27_012757 591 3 G. G. NNP 10_1101-2020_03_27_012757 591 4 et et NNP 10_1101-2020_03_27_012757 591 5 al al NNP 10_1101-2020_03_27_012757 591 6 . . . 10_1101-2020_03_27_012757 592 1 Comprehensive comprehensive JJ 10_1101-2020_03_27_012757 592 2 comparison comparison NN 10_1101-2020_03_27_012757 592 3 of of IN 10_1101-2020_03_27_012757 592 4 molecular molecular JJ 10_1101-2020_03_27_012757 592 5 portraits portrait NNS 10_1101-2020_03_27_012757 592 6 between between IN 10_1101-2020_03_27_012757 592 7 cell cell NN 10_1101-2020_03_27_012757 592 8 lines line NNS 10_1101-2020_03_27_012757 592 9 1015 1015 CD 10_1101-2020_03_27_012757 592 10 and and CC 10_1101-2020_03_27_012757 592 11 tumors tumor NNS 10_1101-2020_03_27_012757 592 12 in in IN 10_1101-2020_03_27_012757 592 13 breast breast NN 10_1101-2020_03_27_012757 592 14 cancer cancer NN 10_1101-2020_03_27_012757 592 15 . . . 10_1101-2020_03_27_012757 593 1 BMC BMC NNP 10_1101-2020_03_27_012757 593 2 Genomics Genomics NNP 10_1101-2020_03_27_012757 593 3 17 17 CD 10_1101-2020_03_27_012757 593 4 Suppl Suppl NNP 10_1101-2020_03_27_012757 593 5 7 7 CD 10_1101-2020_03_27_012757 593 6 , , , 10_1101-2020_03_27_012757 593 7 525 525 CD 10_1101-2020_03_27_012757 593 8 ( ( -LRB- 10_1101-2020_03_27_012757 593 9 2016 2016 CD 10_1101-2020_03_27_012757 593 10 ) ) -RRB- 10_1101-2020_03_27_012757 593 11 . . . 10_1101-2020_03_27_012757 594 1 1016 1016 CD 10_1101-2020_03_27_012757 594 2 13 13 CD 10_1101-2020_03_27_012757 594 3 . . . 10_1101-2020_03_27_012757 595 1 Chen Chen NNP 10_1101-2020_03_27_012757 595 2 , , , 10_1101-2020_03_27_012757 595 3 B. B. NNP 10_1101-2020_03_27_012757 595 4 , , , 10_1101-2020_03_27_012757 595 5 Sirota Sirota NNP 10_1101-2020_03_27_012757 595 6 , , , 10_1101-2020_03_27_012757 595 7 M. M. NNP 10_1101-2020_03_27_012757 595 8 , , , 10_1101-2020_03_27_012757 595 9 Fan Fan NNP 10_1101-2020_03_27_012757 595 10 - - HYPH 10_1101-2020_03_27_012757 595 11 Minogue Minogue NNP 10_1101-2020_03_27_012757 595 12 , , , 10_1101-2020_03_27_012757 595 13 H. H. NNP 10_1101-2020_03_27_012757 595 14 , , , 10_1101-2020_03_27_012757 595 15 Hadley Hadley NNP 10_1101-2020_03_27_012757 595 16 , , , 10_1101-2020_03_27_012757 595 17 D. D. NNP 10_1101-2020_03_27_012757 595 18 & & CC 10_1101-2020_03_27_012757 595 19 Butte Butte NNP 10_1101-2020_03_27_012757 595 20 , , , 10_1101-2020_03_27_012757 595 21 A. a. NN 10_1101-2020_03_27_012757 595 22 J. J. NNP 10_1101-2020_03_27_012757 596 1 Relating relate VBG 10_1101-2020_03_27_012757 596 2 1017 1017 CD 10_1101-2020_03_27_012757 596 3 hepatocellular hepatocellular JJ 10_1101-2020_03_27_012757 596 4 carcinoma carcinoma NN 10_1101-2020_03_27_012757 596 5 tumor tumor NN 10_1101-2020_03_27_012757 596 6 samples sample NNS 10_1101-2020_03_27_012757 596 7 and and CC 10_1101-2020_03_27_012757 596 8 cell cell NN 10_1101-2020_03_27_012757 596 9 lines line NNS 10_1101-2020_03_27_012757 596 10 using use VBG 10_1101-2020_03_27_012757 596 11 gene gene NN 10_1101-2020_03_27_012757 596 12 expression expression NN 10_1101-2020_03_27_012757 596 13 data datum NNS 10_1101-2020_03_27_012757 596 14 1018 1018 CD 10_1101-2020_03_27_012757 596 15 in in IN 10_1101-2020_03_27_012757 596 16 translational translational JJ 10_1101-2020_03_27_012757 596 17 research research NN 10_1101-2020_03_27_012757 596 18 . . . 10_1101-2020_03_27_012757 597 1 BMC BMC NNP 10_1101-2020_03_27_012757 597 2 Med Med NNP 10_1101-2020_03_27_012757 597 3 . . . 10_1101-2020_03_27_012757 598 1 Genomics genomic NNS 10_1101-2020_03_27_012757 598 2 8 8 CD 10_1101-2020_03_27_012757 598 3 Suppl suppl NN 10_1101-2020_03_27_012757 598 4 2 2 CD 10_1101-2020_03_27_012757 598 5 , , , 10_1101-2020_03_27_012757 598 6 S5 s5 NN 10_1101-2020_03_27_012757 598 7 ( ( -LRB- 10_1101-2020_03_27_012757 598 8 2015 2015 CD 10_1101-2020_03_27_012757 598 9 ) ) -RRB- 10_1101-2020_03_27_012757 598 10 . . . 10_1101-2020_03_27_012757 599 1 1019 1019 CD 10_1101-2020_03_27_012757 599 2 14 14 CD 10_1101-2020_03_27_012757 599 3 . . . 10_1101-2020_03_27_012757 600 1 Vincent Vincent NNP 10_1101-2020_03_27_012757 600 2 , , , 10_1101-2020_03_27_012757 600 3 K. K. NNP 10_1101-2020_03_27_012757 600 4 M. M. NNP 10_1101-2020_03_27_012757 600 5 , , , 10_1101-2020_03_27_012757 600 6 Findlay Findlay NNP 10_1101-2020_03_27_012757 600 7 , , , 10_1101-2020_03_27_012757 600 8 S. S. NNP 10_1101-2020_03_27_012757 600 9 D. D. NNP 10_1101-2020_03_27_012757 600 10 & & CC 10_1101-2020_03_27_012757 600 11 Postovit Postovit NNP 10_1101-2020_03_27_012757 600 12 , , , 10_1101-2020_03_27_012757 600 13 L. L. NNP 10_1101-2020_03_27_012757 600 14 M. M. NNP 10_1101-2020_03_27_012757 600 15 Assessing Assessing NNP 10_1101-2020_03_27_012757 600 16 breast breast NN 10_1101-2020_03_27_012757 600 17 cancer cancer NN 10_1101-2020_03_27_012757 600 18 cell cell NN 10_1101-2020_03_27_012757 600 19 lines line NNS 10_1101-2020_03_27_012757 600 20 as as IN 10_1101-2020_03_27_012757 600 21 1020 1020 CD 10_1101-2020_03_27_012757 600 22 tumour tumour NN 10_1101-2020_03_27_012757 600 23 models model NNS 10_1101-2020_03_27_012757 600 24 by by IN 10_1101-2020_03_27_012757 600 25 comparison comparison NN 10_1101-2020_03_27_012757 600 26 of of IN 10_1101-2020_03_27_012757 600 27 mRNA mRNA NNP 10_1101-2020_03_27_012757 600 28 expression expression NNP 10_1101-2020_03_27_012757 600 29 profiles profile NNS 10_1101-2020_03_27_012757 600 30 . . . 10_1101-2020_03_27_012757 601 1 Breast Breast NNP 10_1101-2020_03_27_012757 601 2 Cancer Cancer NNP 10_1101-2020_03_27_012757 601 3 Res Res NNP 10_1101-2020_03_27_012757 601 4 . . . 10_1101-2020_03_27_012757 602 1 1021 1021 CD 10_1101-2020_03_27_012757 602 2 17 17 CD 10_1101-2020_03_27_012757 602 3 , , , 10_1101-2020_03_27_012757 602 4 114 114 CD 10_1101-2020_03_27_012757 602 5 ( ( -LRB- 10_1101-2020_03_27_012757 602 6 2015 2015 CD 10_1101-2020_03_27_012757 602 7 ) ) -RRB- 10_1101-2020_03_27_012757 602 8 . . . 10_1101-2020_03_27_012757 603 1 1022 1022 CD 10_1101-2020_03_27_012757 603 2 15 15 CD 10_1101-2020_03_27_012757 603 3 . . . 10_1101-2020_03_27_012757 604 1 Yu Yu NNP 10_1101-2020_03_27_012757 604 2 , , , 10_1101-2020_03_27_012757 604 3 K. K. NNP 10_1101-2020_03_27_012757 604 4 et et NNP 10_1101-2020_03_27_012757 604 5 al al NNP 10_1101-2020_03_27_012757 604 6 . . . 10_1101-2020_03_27_012757 605 1 Comprehensive comprehensive JJ 10_1101-2020_03_27_012757 605 2 transcriptomic transcriptomic JJ 10_1101-2020_03_27_012757 605 3 analysis analysis NN 10_1101-2020_03_27_012757 605 4 of of IN 10_1101-2020_03_27_012757 605 5 cell cell NN 10_1101-2020_03_27_012757 605 6 lines line NNS 10_1101-2020_03_27_012757 605 7 as as IN 10_1101-2020_03_27_012757 605 8 models model NNS 10_1101-2020_03_27_012757 605 9 of of IN 10_1101-2020_03_27_012757 605 10 1023 1023 CD 10_1101-2020_03_27_012757 605 11 primary primary JJ 10_1101-2020_03_27_012757 605 12 tumors tumor NNS 10_1101-2020_03_27_012757 605 13 across across IN 10_1101-2020_03_27_012757 605 14 22 22 CD 10_1101-2020_03_27_012757 605 15 tumor tumor NN 10_1101-2020_03_27_012757 605 16 types type NNS 10_1101-2020_03_27_012757 605 17 . . . 10_1101-2020_03_27_012757 606 1 Nat Nat NNP 10_1101-2020_03_27_012757 606 2 . . . 10_1101-2020_03_27_012757 607 1 Commun Commun VBN 10_1101-2020_03_27_012757 607 2 . . . 10_1101-2020_03_27_012757 608 1 10 10 CD 10_1101-2020_03_27_012757 608 2 , , , 10_1101-2020_03_27_012757 608 3 3574 3574 CD 10_1101-2020_03_27_012757 608 4 ( ( -LRB- 10_1101-2020_03_27_012757 608 5 2019 2019 CD 10_1101-2020_03_27_012757 608 6 ) ) -RRB- 10_1101-2020_03_27_012757 608 7 . . . 10_1101-2020_03_27_012757 609 1 1024 1024 CD 10_1101-2020_03_27_012757 609 2 16 16 CD 10_1101-2020_03_27_012757 609 3 . . . 10_1101-2020_03_27_012757 610 1 Najgebauer Najgebauer NNP 10_1101-2020_03_27_012757 610 2 , , , 10_1101-2020_03_27_012757 610 3 H. H. NNP 10_1101-2020_03_27_012757 610 4 et et NNP 10_1101-2020_03_27_012757 610 5 al al NNP 10_1101-2020_03_27_012757 610 6 . . . 10_1101-2020_03_27_012757 611 1 CELLector cellector NN 10_1101-2020_03_27_012757 611 2 : : : 10_1101-2020_03_27_012757 611 3 Genomics Genomics NNP 10_1101-2020_03_27_012757 611 4 - - HYPH 10_1101-2020_03_27_012757 611 5 Guided guide VBN 10_1101-2020_03_27_012757 611 6 Selection Selection NNP 10_1101-2020_03_27_012757 611 7 of of IN 10_1101-2020_03_27_012757 611 8 Cancer Cancer NNP 10_1101-2020_03_27_012757 611 9 In in IN 10_1101-2020_03_27_012757 611 10 Vitro Vitro NNP 10_1101-2020_03_27_012757 611 11 1025 1025 CD 10_1101-2020_03_27_012757 611 12 Models model NNS 10_1101-2020_03_27_012757 611 13 . . . 10_1101-2020_03_27_012757 612 1 Cell Cell NNP 10_1101-2020_03_27_012757 612 2 Syst Syst NNP 10_1101-2020_03_27_012757 612 3 . . . 10_1101-2020_03_27_012757 613 1 10 10 CD 10_1101-2020_03_27_012757 613 2 , , , 10_1101-2020_03_27_012757 613 3 424–432.e6 424–432.e6 CD 10_1101-2020_03_27_012757 613 4 ( ( -LRB- 10_1101-2020_03_27_012757 613 5 2020 2020 CD 10_1101-2020_03_27_012757 613 6 ) ) -RRB- 10_1101-2020_03_27_012757 613 7 . . . 10_1101-2020_03_27_012757 614 1 1026 1026 CD 10_1101-2020_03_27_012757 614 2 17 17 CD 10_1101-2020_03_27_012757 614 3 . . . 10_1101-2020_03_27_012757 615 1 Salvadores Salvadores NNP 10_1101-2020_03_27_012757 615 2 , , , 10_1101-2020_03_27_012757 615 3 M. M. NNP 10_1101-2020_03_27_012757 615 4 , , , 10_1101-2020_03_27_012757 615 5 Fuster Fuster NNP 10_1101-2020_03_27_012757 615 6 - - HYPH 10_1101-2020_03_27_012757 615 7 Tormo Tormo NNP 10_1101-2020_03_27_012757 615 8 , , , 10_1101-2020_03_27_012757 615 9 F. F. NNP 10_1101-2020_03_27_012757 615 10 & & CC 10_1101-2020_03_27_012757 615 11 Supek Supek NNP 10_1101-2020_03_27_012757 615 12 , , , 10_1101-2020_03_27_012757 615 13 F. F. NNP 10_1101-2020_03_27_012757 615 14 Matching Matching NNP 10_1101-2020_03_27_012757 615 15 cell cell NN 10_1101-2020_03_27_012757 615 16 lines line NNS 10_1101-2020_03_27_012757 615 17 with with IN 10_1101-2020_03_27_012757 615 18 cancer cancer NN 10_1101-2020_03_27_012757 615 19 type type NN 10_1101-2020_03_27_012757 615 20 1027 1027 CD 10_1101-2020_03_27_012757 615 21 and and CC 10_1101-2020_03_27_012757 615 22 subtype subtype NN 10_1101-2020_03_27_012757 615 23 of of IN 10_1101-2020_03_27_012757 615 24 origin origin NN 10_1101-2020_03_27_012757 615 25 via via IN 10_1101-2020_03_27_012757 615 26 mutational mutational JJ 10_1101-2020_03_27_012757 615 27 , , , 10_1101-2020_03_27_012757 615 28 epigenomic epigenomic JJ 10_1101-2020_03_27_012757 615 29 , , , 10_1101-2020_03_27_012757 615 30 and and CC 10_1101-2020_03_27_012757 615 31 transcriptomic transcriptomic JJ 10_1101-2020_03_27_012757 615 32 patterns pattern NNS 10_1101-2020_03_27_012757 615 33 . . . 10_1101-2020_03_27_012757 616 1 Sci Sci NNP 10_1101-2020_03_27_012757 616 2 . . . 10_1101-2020_03_27_012757 617 1 1028 1028 CD 10_1101-2020_03_27_012757 617 2 Adv Adv NNP 10_1101-2020_03_27_012757 617 3 . . . 10_1101-2020_03_27_012757 618 1 6 6 CD 10_1101-2020_03_27_012757 618 2 , , , 10_1101-2020_03_27_012757 618 3 ( ( -LRB- 10_1101-2020_03_27_012757 618 4 2020 2020 CD 10_1101-2020_03_27_012757 618 5 ) ) -RRB- 10_1101-2020_03_27_012757 618 6 . . . 10_1101-2020_03_27_012757 619 1 1029 1029 CD 10_1101-2020_03_27_012757 619 2 18 18 CD 10_1101-2020_03_27_012757 619 3 . . . 10_1101-2020_03_27_012757 620 1 Guernet Guernet NNP 10_1101-2020_03_27_012757 620 2 , , , 10_1101-2020_03_27_012757 620 3 A. a. NN 10_1101-2020_03_27_012757 621 1 & & CC 10_1101-2020_03_27_012757 621 2 Grumolato Grumolato NNP 10_1101-2020_03_27_012757 621 3 , , , 10_1101-2020_03_27_012757 621 4 L. L. NNP 10_1101-2020_03_27_012757 621 5 CRISPR CRISPR NNP 10_1101-2020_03_27_012757 621 6 / / SYM 10_1101-2020_03_27_012757 621 7 Cas9 Cas9 NNP 10_1101-2020_03_27_012757 621 8 editing editing NN 10_1101-2020_03_27_012757 621 9 of of IN 10_1101-2020_03_27_012757 621 10 the the DT 10_1101-2020_03_27_012757 621 11 genome genome NN 10_1101-2020_03_27_012757 621 12 for for IN 10_1101-2020_03_27_012757 621 13 cancer cancer NN 10_1101-2020_03_27_012757 621 14 1030 1030 CD 10_1101-2020_03_27_012757 621 15 modeling modeling NN 10_1101-2020_03_27_012757 621 16 . . . 10_1101-2020_03_27_012757 622 1 Methods Methods NNP 10_1101-2020_03_27_012757 622 2 121 121 CD 10_1101-2020_03_27_012757 622 3 - - SYM 10_1101-2020_03_27_012757 622 4 122 122 CD 10_1101-2020_03_27_012757 622 5 , , , 10_1101-2020_03_27_012757 622 6 130–137 130–137 CD 10_1101-2020_03_27_012757 622 7 ( ( -LRB- 10_1101-2020_03_27_012757 622 8 2017 2017 CD 10_1101-2020_03_27_012757 622 9 ) ) -RRB- 10_1101-2020_03_27_012757 622 10 . . . 10_1101-2020_03_27_012757 623 1 1031 1031 CD 10_1101-2020_03_27_012757 623 2 19 19 CD 10_1101-2020_03_27_012757 623 3 . . . 10_1101-2020_03_27_012757 624 1 Gargiulo Gargiulo NNP 10_1101-2020_03_27_012757 624 2 , , , 10_1101-2020_03_27_012757 624 3 G. G. NNP 10_1101-2020_03_27_012757 624 4 Next Next NNP 10_1101-2020_03_27_012757 624 5 - - HYPH 10_1101-2020_03_27_012757 624 6 Generation Generation NNP 10_1101-2020_03_27_012757 624 7 in in IN 10_1101-2020_03_27_012757 624 8 vivo vivo NN 10_1101-2020_03_27_012757 624 9 Modeling Modeling NNP 10_1101-2020_03_27_012757 624 10 of of IN 10_1101-2020_03_27_012757 624 11 Human Human NNP 10_1101-2020_03_27_012757 624 12 Cancers Cancers NNPS 10_1101-2020_03_27_012757 624 13 . . . 10_1101-2020_03_27_012757 625 1 Front front NN 10_1101-2020_03_27_012757 625 2 . . . 10_1101-2020_03_27_012757 626 1 Oncol Oncol NNP 10_1101-2020_03_27_012757 626 2 . . . 10_1101-2020_03_27_012757 627 1 8 8 CD 10_1101-2020_03_27_012757 627 2 , , , 10_1101-2020_03_27_012757 627 3 1032 1032 CD 10_1101-2020_03_27_012757 627 4 429 429 CD 10_1101-2020_03_27_012757 627 5 ( ( -LRB- 10_1101-2020_03_27_012757 627 6 2018 2018 CD 10_1101-2020_03_27_012757 627 7 ) ) -RRB- 10_1101-2020_03_27_012757 627 8 . . . 10_1101-2020_03_27_012757 628 1 1033 1033 CD 10_1101-2020_03_27_012757 628 2 20 20 CD 10_1101-2020_03_27_012757 628 3 . . . 10_1101-2020_03_27_012757 629 1 Gao Gao NNP 10_1101-2020_03_27_012757 629 2 , , , 10_1101-2020_03_27_012757 629 3 H. H. NNP 10_1101-2020_03_27_012757 629 4 et et NNP 10_1101-2020_03_27_012757 629 5 al al NNP 10_1101-2020_03_27_012757 629 6 . . . 10_1101-2020_03_27_012757 630 1 High high JJ 10_1101-2020_03_27_012757 630 2 - - HYPH 10_1101-2020_03_27_012757 630 3 throughput throughput NN 10_1101-2020_03_27_012757 630 4 screening screening NN 10_1101-2020_03_27_012757 630 5 using use VBG 10_1101-2020_03_27_012757 630 6 patient patient NN 10_1101-2020_03_27_012757 630 7 - - HYPH 10_1101-2020_03_27_012757 630 8 derived derive VBN 10_1101-2020_03_27_012757 630 9 tumor tumor NN 10_1101-2020_03_27_012757 630 10 xenografts xenograft NNS 10_1101-2020_03_27_012757 630 11 to to IN 10_1101-2020_03_27_012757 630 12 1034 1034 CD 10_1101-2020_03_27_012757 630 13 predict predict VB 10_1101-2020_03_27_012757 630 14 clinical clinical JJ 10_1101-2020_03_27_012757 630 15 trial trial NN 10_1101-2020_03_27_012757 630 16 drug drug NN 10_1101-2020_03_27_012757 630 17 response response NN 10_1101-2020_03_27_012757 630 18 . . . 10_1101-2020_03_27_012757 631 1 Nat Nat NNP 10_1101-2020_03_27_012757 631 2 . . . 10_1101-2020_03_27_012757 632 1 Med Med NNP 10_1101-2020_03_27_012757 632 2 . . . 10_1101-2020_03_27_012757 633 1 21 21 CD 10_1101-2020_03_27_012757 633 2 , , , 10_1101-2020_03_27_012757 633 3 1318–1325 1318–1325 CD 10_1101-2020_03_27_012757 633 4 ( ( -LRB- 10_1101-2020_03_27_012757 633 5 2015 2015 CD 10_1101-2020_03_27_012757 633 6 ) ) -RRB- 10_1101-2020_03_27_012757 633 7 . . . 10_1101-2020_03_27_012757 634 1 1035 1035 CD 10_1101-2020_03_27_012757 634 2 21 21 CD 10_1101-2020_03_27_012757 634 3 . . . 10_1101-2020_03_27_012757 635 1 Cahan Cahan NNP 10_1101-2020_03_27_012757 635 2 , , , 10_1101-2020_03_27_012757 635 3 P. P. NNP 10_1101-2020_03_27_012757 635 4 et et NNP 10_1101-2020_03_27_012757 635 5 al al NNP 10_1101-2020_03_27_012757 635 6 . . . 10_1101-2020_03_27_012757 636 1 CellNet CellNet NNP 10_1101-2020_03_27_012757 636 2 : : : 10_1101-2020_03_27_012757 636 3 network network NN 10_1101-2020_03_27_012757 636 4 biology biology NN 10_1101-2020_03_27_012757 636 5 applied apply VBD 10_1101-2020_03_27_012757 636 6 to to TO 10_1101-2020_03_27_012757 636 7 stem stem VB 10_1101-2020_03_27_012757 636 8 cell cell NN 10_1101-2020_03_27_012757 636 9 engineering engineering NN 10_1101-2020_03_27_012757 636 10 . . . 10_1101-2020_03_27_012757 637 1 Cell cell NN 10_1101-2020_03_27_012757 637 2 158 158 CD 10_1101-2020_03_27_012757 637 3 , , , 10_1101-2020_03_27_012757 637 4 1036 1036 CD 10_1101-2020_03_27_012757 637 5 903–915 903–915 CD 10_1101-2020_03_27_012757 637 6 ( ( -LRB- 10_1101-2020_03_27_012757 637 7 2014 2014 CD 10_1101-2020_03_27_012757 637 8 ) ) -RRB- 10_1101-2020_03_27_012757 637 9 . . . 10_1101-2020_03_27_012757 638 1 1037 1037 CD 10_1101-2020_03_27_012757 638 2 22 22 CD 10_1101-2020_03_27_012757 638 3 . . . 10_1101-2020_03_27_012757 639 1 Radley Radley NNP 10_1101-2020_03_27_012757 639 2 , , , 10_1101-2020_03_27_012757 639 3 A. A. NNP 10_1101-2020_03_27_012757 639 4 H. H. NNP 10_1101-2020_03_27_012757 639 5 et et NNP 10_1101-2020_03_27_012757 639 6 al al NNP 10_1101-2020_03_27_012757 639 7 . . . 10_1101-2020_03_27_012757 640 1 Assessment assessment NN 10_1101-2020_03_27_012757 640 2 of of IN 10_1101-2020_03_27_012757 640 3 engineered engineered JJ 10_1101-2020_03_27_012757 640 4 cells cell NNS 10_1101-2020_03_27_012757 640 5 using use VBG 10_1101-2020_03_27_012757 640 6 CellNet CellNet NNP 10_1101-2020_03_27_012757 640 7 and and CC 10_1101-2020_03_27_012757 640 8 RNA RNA NNP 10_1101-2020_03_27_012757 640 9 - - HYPH 10_1101-2020_03_27_012757 640 10 seq seq NNP 10_1101-2020_03_27_012757 640 11 . . . 10_1101-2020_03_27_012757 641 1 1038 1038 CD 10_1101-2020_03_27_012757 641 2 Nat Nat NNP 10_1101-2020_03_27_012757 641 3 . . . 10_1101-2020_03_27_012757 642 1 Protoc Protoc NNP 10_1101-2020_03_27_012757 642 2 . . . 10_1101-2020_03_27_012757 643 1 12 12 CD 10_1101-2020_03_27_012757 643 2 , , , 10_1101-2020_03_27_012757 643 3 1089–1102 1089–1102 CD 10_1101-2020_03_27_012757 643 4 ( ( -LRB- 10_1101-2020_03_27_012757 643 5 2017 2017 CD 10_1101-2020_03_27_012757 643 6 ) ) -RRB- 10_1101-2020_03_27_012757 643 7 . . . 10_1101-2020_03_27_012757 644 1 1039 1039 CD 10_1101-2020_03_27_012757 644 2 23 23 CD 10_1101-2020_03_27_012757 644 3 . . . 10_1101-2020_03_27_012757 645 1 Tan Tan NNP 10_1101-2020_03_27_012757 645 2 , , , 10_1101-2020_03_27_012757 645 3 Y. Y. NNP 10_1101-2020_03_27_012757 646 1 & & CC 10_1101-2020_03_27_012757 646 2 Cahan Cahan NNP 10_1101-2020_03_27_012757 646 3 , , , 10_1101-2020_03_27_012757 646 4 P. P. NNP 10_1101-2020_03_27_012757 646 5 SingleCellNet singlecellnet XX 10_1101-2020_03_27_012757 646 6 : : : 10_1101-2020_03_27_012757 646 7 A a DT 10_1101-2020_03_27_012757 646 8 Computational Computational NNP 10_1101-2020_03_27_012757 646 9 Tool Tool NNP 10_1101-2020_03_27_012757 646 10 to to TO 10_1101-2020_03_27_012757 646 11 Classify classify VB 10_1101-2020_03_27_012757 646 12 Single single JJ 10_1101-2020_03_27_012757 646 13 Cell cell NN 10_1101-2020_03_27_012757 646 14 1040 1040 CD 10_1101-2020_03_27_012757 646 15 RNA RNA NNP 10_1101-2020_03_27_012757 646 16 - - HYPH 10_1101-2020_03_27_012757 646 17 Seq Seq NNP 10_1101-2020_03_27_012757 646 18 Data Data NNPS 10_1101-2020_03_27_012757 646 19 Across Across NNP 10_1101-2020_03_27_012757 646 20 Platforms Platforms NNPS 10_1101-2020_03_27_012757 646 21 and and CC 10_1101-2020_03_27_012757 646 22 Across Across NNP 10_1101-2020_03_27_012757 646 23 Species Species NNPS 10_1101-2020_03_27_012757 646 24 . . . 10_1101-2020_03_27_012757 647 1 Cell Cell NNP 10_1101-2020_03_27_012757 647 2 Syst Syst NNP 10_1101-2020_03_27_012757 647 3 . . . 10_1101-2020_03_27_012757 648 1 9 9 CD 10_1101-2020_03_27_012757 648 2 , , , 10_1101-2020_03_27_012757 648 3 207–213.e2 207–213.e2 NNS 10_1101-2020_03_27_012757 648 4 1041 1041 CD 10_1101-2020_03_27_012757 648 5 ( ( -LRB- 10_1101-2020_03_27_012757 648 6 2019 2019 CD 10_1101-2020_03_27_012757 648 7 ) ) -RRB- 10_1101-2020_03_27_012757 648 8 . . . 10_1101-2020_03_27_012757 649 1 1042 1042 CD 10_1101-2020_03_27_012757 649 2 24 24 CD 10_1101-2020_03_27_012757 649 3 . . . 10_1101-2020_03_27_012757 650 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 650 2 Genome Genome NNP 10_1101-2020_03_27_012757 650 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 650 4 Network Network NNP 10_1101-2020_03_27_012757 650 5 . . . 10_1101-2020_03_27_012757 651 1 Comprehensive comprehensive JJ 10_1101-2020_03_27_012757 651 2 molecular molecular JJ 10_1101-2020_03_27_012757 651 3 characterization characterization NN 10_1101-2020_03_27_012757 651 4 of of IN 10_1101-2020_03_27_012757 651 5 1043 1043 CD 10_1101-2020_03_27_012757 651 6 human human JJ 10_1101-2020_03_27_012757 651 7 colon colon NN 10_1101-2020_03_27_012757 651 8 and and CC 10_1101-2020_03_27_012757 651 9 rectal rectal JJ 10_1101-2020_03_27_012757 651 10 cancer cancer NN 10_1101-2020_03_27_012757 651 11 . . . 10_1101-2020_03_27_012757 652 1 Nature nature NN 10_1101-2020_03_27_012757 652 2 487 487 CD 10_1101-2020_03_27_012757 652 3 , , , 10_1101-2020_03_27_012757 652 4 330–337 330–337 CD 10_1101-2020_03_27_012757 652 5 ( ( -LRB- 10_1101-2020_03_27_012757 652 6 2012 2012 CD 10_1101-2020_03_27_012757 652 7 ) ) -RRB- 10_1101-2020_03_27_012757 652 8 . . . 10_1101-2020_03_27_012757 653 1 1044 1044 CD 10_1101-2020_03_27_012757 653 2 25 25 CD 10_1101-2020_03_27_012757 653 3 . . . 10_1101-2020_03_27_012757 654 1 Zhang Zhang NNP 10_1101-2020_03_27_012757 654 2 , , , 10_1101-2020_03_27_012757 654 3 J. J. NNP 10_1101-2020_03_27_012757 654 4 et et NNP 10_1101-2020_03_27_012757 654 5 al al NNP 10_1101-2020_03_27_012757 654 6 . . . 10_1101-2020_03_27_012757 655 1 International International NNP 10_1101-2020_03_27_012757 655 2 Cancer Cancer NNP 10_1101-2020_03_27_012757 655 3 Genome Genome NNP 10_1101-2020_03_27_012757 655 4 Consortium Consortium NNP 10_1101-2020_03_27_012757 655 5 Data Data NNP 10_1101-2020_03_27_012757 655 6 Portal Portal NNP 10_1101-2020_03_27_012757 655 7 -- -- : 10_1101-2020_03_27_012757 655 8 a a DT 10_1101-2020_03_27_012757 655 9 one one CD 10_1101-2020_03_27_012757 655 10 - - HYPH 10_1101-2020_03_27_012757 655 11 stop stop NN 10_1101-2020_03_27_012757 655 12 1045 1045 CD 10_1101-2020_03_27_012757 655 13 shop shop NN 10_1101-2020_03_27_012757 655 14 for for IN 10_1101-2020_03_27_012757 655 15 cancer cancer NN 10_1101-2020_03_27_012757 655 16 genomics genomic NNS 10_1101-2020_03_27_012757 655 17 data datum NNS 10_1101-2020_03_27_012757 655 18 . . . 10_1101-2020_03_27_012757 656 1 Database Database NNP 10_1101-2020_03_27_012757 656 2 ( ( -LRB- 10_1101-2020_03_27_012757 656 3 Oxford Oxford NNP 10_1101-2020_03_27_012757 656 4 ) ) -RRB- 10_1101-2020_03_27_012757 656 5 2011 2011 CD 10_1101-2020_03_27_012757 656 6 , , , 10_1101-2020_03_27_012757 656 7 bar026 bar026 NFP 10_1101-2020_03_27_012757 656 8 ( ( -LRB- 10_1101-2020_03_27_012757 656 9 2011 2011 CD 10_1101-2020_03_27_012757 656 10 ) ) -RRB- 10_1101-2020_03_27_012757 656 11 . . . 10_1101-2020_03_27_012757 657 1 1046 1046 CD 10_1101-2020_03_27_012757 657 2 26 26 CD 10_1101-2020_03_27_012757 657 3 . . . 10_1101-2020_03_27_012757 658 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 658 2 Genome Genome NNP 10_1101-2020_03_27_012757 658 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 658 4 Network Network NNP 10_1101-2020_03_27_012757 658 5 . . . 10_1101-2020_03_27_012757 659 1 Comprehensive comprehensive JJ 10_1101-2020_03_27_012757 659 2 molecular molecular JJ 10_1101-2020_03_27_012757 659 3 portraits portrait NNS 10_1101-2020_03_27_012757 659 4 of of IN 10_1101-2020_03_27_012757 659 5 human human JJ 10_1101-2020_03_27_012757 659 6 1047 1047 CD 10_1101-2020_03_27_012757 659 7 breast breast NN 10_1101-2020_03_27_012757 659 8 tumours tumour NNS 10_1101-2020_03_27_012757 659 9 . . . 10_1101-2020_03_27_012757 660 1 Nature nature NN 10_1101-2020_03_27_012757 660 2 490 490 CD 10_1101-2020_03_27_012757 660 3 , , , 10_1101-2020_03_27_012757 660 4 61–70 61–70 CD 10_1101-2020_03_27_012757 660 5 ( ( -LRB- 10_1101-2020_03_27_012757 660 6 2012 2012 CD 10_1101-2020_03_27_012757 660 7 ) ) -RRB- 10_1101-2020_03_27_012757 660 8 . . . 10_1101-2020_03_27_012757 661 1 1048 1048 CD 10_1101-2020_03_27_012757 661 2 27 27 CD 10_1101-2020_03_27_012757 661 3 . . . 10_1101-2020_03_27_012757 662 1 Parker Parker NNP 10_1101-2020_03_27_012757 662 2 , , , 10_1101-2020_03_27_012757 662 3 J. J. NNP 10_1101-2020_03_27_012757 662 4 S. S. NNP 10_1101-2020_03_27_012757 662 5 et et NNP 10_1101-2020_03_27_012757 662 6 al al NNP 10_1101-2020_03_27_012757 662 7 . . . 10_1101-2020_03_27_012757 663 1 Supervised supervise VBN 10_1101-2020_03_27_012757 663 2 risk risk NN 10_1101-2020_03_27_012757 663 3 predictor predictor NN 10_1101-2020_03_27_012757 663 4 of of IN 10_1101-2020_03_27_012757 663 5 breast breast NN 10_1101-2020_03_27_012757 663 6 cancer cancer NN 10_1101-2020_03_27_012757 663 7 based base VBN 10_1101-2020_03_27_012757 663 8 on on IN 10_1101-2020_03_27_012757 663 9 intrinsic intrinsic JJ 10_1101-2020_03_27_012757 663 10 1049 1049 CD 10_1101-2020_03_27_012757 663 11 subtypes subtype NNS 10_1101-2020_03_27_012757 663 12 . . . 10_1101-2020_03_27_012757 664 1 J. J. NNP 10_1101-2020_03_27_012757 664 2 Clin Clin NNP 10_1101-2020_03_27_012757 664 3 . . . 10_1101-2020_03_27_012757 665 1 Oncol Oncol NNP 10_1101-2020_03_27_012757 665 2 . . . 10_1101-2020_03_27_012757 666 1 27 27 CD 10_1101-2020_03_27_012757 666 2 , , , 10_1101-2020_03_27_012757 666 3 1160–1167 1160–1167 CD 10_1101-2020_03_27_012757 666 4 ( ( -LRB- 10_1101-2020_03_27_012757 666 5 2009 2009 CD 10_1101-2020_03_27_012757 666 6 ) ) -RRB- 10_1101-2020_03_27_012757 666 7 . . . 10_1101-2020_03_27_012757 667 1 1050 1050 CD 10_1101-2020_03_27_012757 667 2 .CC .CC : 10_1101-2020_03_27_012757 667 3 - - : 10_1101-2020_03_27_012757 667 4 BY by IN 10_1101-2020_03_27_012757 667 5 - - HYPH 10_1101-2020_03_27_012757 667 6 NC NC NNP 10_1101-2020_03_27_012757 667 7 - - HYPH 10_1101-2020_03_27_012757 667 8 ND ND NNP 10_1101-2020_03_27_012757 667 9 4.0 4.0 CD 10_1101-2020_03_27_012757 667 10 International International NNP 10_1101-2020_03_27_012757 667 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 667 12 under under IN 10_1101-2020_03_27_012757 667 13 a a DT 10_1101-2020_03_27_012757 667 14 ( ( -LRB- 10_1101-2020_03_27_012757 667 15 which which WDT 10_1101-2020_03_27_012757 667 16 was be VBD 10_1101-2020_03_27_012757 667 17 not not RB 10_1101-2020_03_27_012757 667 18 certified certify VBN 10_1101-2020_03_27_012757 667 19 by by IN 10_1101-2020_03_27_012757 667 20 peer peer NN 10_1101-2020_03_27_012757 667 21 review review NN 10_1101-2020_03_27_012757 667 22 ) ) -RRB- 10_1101-2020_03_27_012757 667 23 is be VBZ 10_1101-2020_03_27_012757 667 24 the the DT 10_1101-2020_03_27_012757 667 25 author author NN 10_1101-2020_03_27_012757 667 26 / / SYM 10_1101-2020_03_27_012757 667 27 funder funder NN 10_1101-2020_03_27_012757 667 28 , , , 10_1101-2020_03_27_012757 667 29 who who WP 10_1101-2020_03_27_012757 667 30 has have VBZ 10_1101-2020_03_27_012757 667 31 granted grant VBN 10_1101-2020_03_27_012757 667 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 667 33 a a DT 10_1101-2020_03_27_012757 667 34 license license NN 10_1101-2020_03_27_012757 667 35 to to TO 10_1101-2020_03_27_012757 667 36 display display VB 10_1101-2020_03_27_012757 667 37 the the DT 10_1101-2020_03_27_012757 667 38 preprint preprint NN 10_1101-2020_03_27_012757 667 39 in in IN 10_1101-2020_03_27_012757 667 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 667 41 . . . 10_1101-2020_03_27_012757 668 1 It -PRON- PRP 10_1101-2020_03_27_012757 668 2 is be VBZ 10_1101-2020_03_27_012757 668 3 made make VBN 10_1101-2020_03_27_012757 668 4 The the DT 10_1101-2020_03_27_012757 668 5 copyright copyright NN 10_1101-2020_03_27_012757 668 6 holder holder NN 10_1101-2020_03_27_012757 668 7 for for IN 10_1101-2020_03_27_012757 668 8 this this DT 10_1101-2020_03_27_012757 668 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 668 10 version version NN 10_1101-2020_03_27_012757 668 11 posted post VBD 10_1101-2020_03_27_012757 668 12 January January NNP 10_1101-2020_03_27_012757 668 13 9 9 CD 10_1101-2020_03_27_012757 668 14 , , , 10_1101-2020_03_27_012757 668 15 2021 2021 CD 10_1101-2020_03_27_012757 668 16 . . . 10_1101-2020_03_27_012757 668 17 ; ; : 10_1101-2020_03_27_012757 668 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 668 19 : : : 10_1101-2020_03_27_012757 668 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 668 21 preprint preprint NN 10_1101-2020_03_27_012757 668 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 668 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 668 24 39 39 CD 10_1101-2020_03_27_012757 668 25 28 28 CD 10_1101-2020_03_27_012757 668 26 . . . 10_1101-2020_03_27_012757 669 1 Wilkerson Wilkerson NNP 10_1101-2020_03_27_012757 669 2 , , , 10_1101-2020_03_27_012757 669 3 M. M. NNP 10_1101-2020_03_27_012757 669 4 D. D. NNP 10_1101-2020_03_27_012757 669 5 et et NNP 10_1101-2020_03_27_012757 669 6 al al NNP 10_1101-2020_03_27_012757 669 7 . . . 10_1101-2020_03_27_012757 670 1 Lung Lung NNP 10_1101-2020_03_27_012757 670 2 squamous squamous JJ 10_1101-2020_03_27_012757 670 3 cell cell NN 10_1101-2020_03_27_012757 670 4 carcinoma carcinoma NN 10_1101-2020_03_27_012757 670 5 mRNA mRNA NNP 10_1101-2020_03_27_012757 670 6 expression expression NNP 10_1101-2020_03_27_012757 670 7 subtypes subtype NNS 10_1101-2020_03_27_012757 670 8 1051 1051 CD 10_1101-2020_03_27_012757 670 9 are be VBP 10_1101-2020_03_27_012757 670 10 reproducible reproducible JJ 10_1101-2020_03_27_012757 670 11 , , , 10_1101-2020_03_27_012757 670 12 clinically clinically RB 10_1101-2020_03_27_012757 670 13 important important JJ 10_1101-2020_03_27_012757 670 14 , , , 10_1101-2020_03_27_012757 670 15 and and CC 10_1101-2020_03_27_012757 670 16 correspond correspond VB 10_1101-2020_03_27_012757 670 17 to to IN 10_1101-2020_03_27_012757 670 18 normal normal JJ 10_1101-2020_03_27_012757 670 19 cell cell NN 10_1101-2020_03_27_012757 670 20 types type NNS 10_1101-2020_03_27_012757 670 21 . . . 10_1101-2020_03_27_012757 671 1 Clin Clin NNP 10_1101-2020_03_27_012757 671 2 . . . 10_1101-2020_03_27_012757 672 1 1052 1052 CD 10_1101-2020_03_27_012757 672 2 Cancer Cancer NNP 10_1101-2020_03_27_012757 672 3 Res Res NNP 10_1101-2020_03_27_012757 672 4 . . . 10_1101-2020_03_27_012757 673 1 16 16 CD 10_1101-2020_03_27_012757 673 2 , , , 10_1101-2020_03_27_012757 673 3 4864–4875 4864–4875 CD 10_1101-2020_03_27_012757 673 4 ( ( -LRB- 10_1101-2020_03_27_012757 673 5 2010 2010 CD 10_1101-2020_03_27_012757 673 6 ) ) -RRB- 10_1101-2020_03_27_012757 673 7 . . . 10_1101-2020_03_27_012757 674 1 1053 1053 CD 10_1101-2020_03_27_012757 674 2 29 29 CD 10_1101-2020_03_27_012757 674 3 . . . 10_1101-2020_03_27_012757 675 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 675 2 Genome Genome NNP 10_1101-2020_03_27_012757 675 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 675 4 Research Research NNP 10_1101-2020_03_27_012757 675 5 Network Network NNP 10_1101-2020_03_27_012757 675 6 . . . 10_1101-2020_03_27_012757 676 1 Electronic electronic JJ 10_1101-2020_03_27_012757 676 2 address address NN 10_1101-2020_03_27_012757 676 3 : : : 10_1101-2020_03_27_012757 676 4 1054 1054 CD 10_1101-2020_03_27_012757 676 5 andrew_aguirre@dfci.harvard.edu andrew_aguirre@dfci.harvard.edu NNP 10_1101-2020_03_27_012757 676 6 & & CC 10_1101-2020_03_27_012757 676 7 Cancer Cancer NNP 10_1101-2020_03_27_012757 676 8 Genome Genome NNP 10_1101-2020_03_27_012757 676 9 Atlas Atlas NNP 10_1101-2020_03_27_012757 676 10 Research Research NNP 10_1101-2020_03_27_012757 676 11 Network Network NNP 10_1101-2020_03_27_012757 676 12 . . . 10_1101-2020_03_27_012757 677 1 1055 1055 CD 10_1101-2020_03_27_012757 677 2 Integrated integrated JJ 10_1101-2020_03_27_012757 677 3 genomic genomic JJ 10_1101-2020_03_27_012757 677 4 characterization characterization NN 10_1101-2020_03_27_012757 677 5 of of IN 10_1101-2020_03_27_012757 677 6 pancreatic pancreatic JJ 10_1101-2020_03_27_012757 677 7 ductal ductal JJ 10_1101-2020_03_27_012757 677 8 adenocarcinoma adenocarcinoma NN 10_1101-2020_03_27_012757 677 9 . . . 10_1101-2020_03_27_012757 678 1 Cancer cancer NN 10_1101-2020_03_27_012757 678 2 1056 1056 CD 10_1101-2020_03_27_012757 678 3 Cell Cell NNP 10_1101-2020_03_27_012757 678 4 32 32 CD 10_1101-2020_03_27_012757 678 5 , , , 10_1101-2020_03_27_012757 678 6 185–203.e13 185–203.e13 CD 10_1101-2020_03_27_012757 678 7 ( ( -LRB- 10_1101-2020_03_27_012757 678 8 2017 2017 CD 10_1101-2020_03_27_012757 678 9 ) ) -RRB- 10_1101-2020_03_27_012757 678 10 . . . 10_1101-2020_03_27_012757 679 1 1057 1057 CD 10_1101-2020_03_27_012757 679 2 30 30 CD 10_1101-2020_03_27_012757 679 3 . . . 10_1101-2020_03_27_012757 680 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 680 2 Genome Genome NNP 10_1101-2020_03_27_012757 680 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 680 4 Research Research NNP 10_1101-2020_03_27_012757 680 5 Network Network NNP 10_1101-2020_03_27_012757 680 6 et et NNP 10_1101-2020_03_27_012757 680 7 al al NNP 10_1101-2020_03_27_012757 680 8 . . . 10_1101-2020_03_27_012757 681 1 Integrated integrate VBN 10_1101-2020_03_27_012757 681 2 genomic genomic JJ 10_1101-2020_03_27_012757 681 3 characterization characterization NN 10_1101-2020_03_27_012757 681 4 1058 1058 CD 10_1101-2020_03_27_012757 681 5 of of IN 10_1101-2020_03_27_012757 681 6 endometrial endometrial JJ 10_1101-2020_03_27_012757 681 7 carcinoma carcinoma NN 10_1101-2020_03_27_012757 681 8 . . . 10_1101-2020_03_27_012757 682 1 Nature nature NN 10_1101-2020_03_27_012757 682 2 497 497 CD 10_1101-2020_03_27_012757 682 3 , , , 10_1101-2020_03_27_012757 682 4 67–73 67–73 CD 10_1101-2020_03_27_012757 682 5 ( ( -LRB- 10_1101-2020_03_27_012757 682 6 2013 2013 CD 10_1101-2020_03_27_012757 682 7 ) ) -RRB- 10_1101-2020_03_27_012757 682 8 . . . 10_1101-2020_03_27_012757 683 1 1059 1059 CD 10_1101-2020_03_27_012757 683 2 31 31 CD 10_1101-2020_03_27_012757 683 3 . . . 10_1101-2020_03_27_012757 684 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 684 2 Genome Genome NNP 10_1101-2020_03_27_012757 684 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 684 4 Research Research NNP 10_1101-2020_03_27_012757 684 5 Network Network NNP 10_1101-2020_03_27_012757 684 6 et et NNP 10_1101-2020_03_27_012757 684 7 al al NNP 10_1101-2020_03_27_012757 684 8 . . . 10_1101-2020_03_27_012757 685 1 Integrated integrate VBN 10_1101-2020_03_27_012757 685 2 genomic genomic JJ 10_1101-2020_03_27_012757 685 3 characterization characterization NN 10_1101-2020_03_27_012757 685 4 1060 1060 CD 10_1101-2020_03_27_012757 685 5 of of IN 10_1101-2020_03_27_012757 685 6 oesophageal oesophageal JJ 10_1101-2020_03_27_012757 685 7 carcinoma carcinoma NN 10_1101-2020_03_27_012757 685 8 . . . 10_1101-2020_03_27_012757 686 1 Nature nature NN 10_1101-2020_03_27_012757 686 2 541 541 CD 10_1101-2020_03_27_012757 686 3 , , , 10_1101-2020_03_27_012757 686 4 169–175 169–175 CD 10_1101-2020_03_27_012757 686 5 ( ( -LRB- 10_1101-2020_03_27_012757 686 6 2017 2017 CD 10_1101-2020_03_27_012757 686 7 ) ) -RRB- 10_1101-2020_03_27_012757 686 8 . . . 10_1101-2020_03_27_012757 687 1 1061 1061 CD 10_1101-2020_03_27_012757 687 2 32 32 CD 10_1101-2020_03_27_012757 687 3 . . . 10_1101-2020_03_27_012757 688 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 688 2 Genome Genome NNP 10_1101-2020_03_27_012757 688 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 688 4 Network Network NNP 10_1101-2020_03_27_012757 688 5 . . . 10_1101-2020_03_27_012757 689 1 Comprehensive comprehensive JJ 10_1101-2020_03_27_012757 689 2 genomic genomic JJ 10_1101-2020_03_27_012757 689 3 characterization characterization NN 10_1101-2020_03_27_012757 689 4 of of IN 10_1101-2020_03_27_012757 689 5 head head NN 10_1101-2020_03_27_012757 689 6 1062 1062 CD 10_1101-2020_03_27_012757 689 7 and and CC 10_1101-2020_03_27_012757 689 8 neck neck NN 10_1101-2020_03_27_012757 689 9 squamous squamous JJ 10_1101-2020_03_27_012757 689 10 cell cell NN 10_1101-2020_03_27_012757 689 11 carcinomas carcinoma NNS 10_1101-2020_03_27_012757 689 12 . . . 10_1101-2020_03_27_012757 690 1 Nature nature NN 10_1101-2020_03_27_012757 690 2 517 517 CD 10_1101-2020_03_27_012757 690 3 , , , 10_1101-2020_03_27_012757 690 4 576–582 576–582 NNP 10_1101-2020_03_27_012757 690 5 ( ( -LRB- 10_1101-2020_03_27_012757 690 6 2015 2015 CD 10_1101-2020_03_27_012757 690 7 ) ) -RRB- 10_1101-2020_03_27_012757 690 8 . . . 10_1101-2020_03_27_012757 691 1 1063 1063 CD 10_1101-2020_03_27_012757 691 2 33 33 CD 10_1101-2020_03_27_012757 691 3 . . . 10_1101-2020_03_27_012757 692 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 692 2 Genome Genome NNP 10_1101-2020_03_27_012757 692 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 692 4 Research Research NNP 10_1101-2020_03_27_012757 692 5 Network Network NNP 10_1101-2020_03_27_012757 692 6 . . . 10_1101-2020_03_27_012757 693 1 Comprehensive comprehensive JJ 10_1101-2020_03_27_012757 693 2 molecular molecular JJ 10_1101-2020_03_27_012757 693 3 1064 1064 CD 10_1101-2020_03_27_012757 693 4 characterization characterization NN 10_1101-2020_03_27_012757 693 5 of of IN 10_1101-2020_03_27_012757 693 6 clear clear JJ 10_1101-2020_03_27_012757 693 7 cell cell NN 10_1101-2020_03_27_012757 693 8 renal renal JJ 10_1101-2020_03_27_012757 693 9 cell cell NN 10_1101-2020_03_27_012757 693 10 carcinoma carcinoma NN 10_1101-2020_03_27_012757 693 11 . . . 10_1101-2020_03_27_012757 694 1 Nature nature NN 10_1101-2020_03_27_012757 694 2 499 499 CD 10_1101-2020_03_27_012757 694 3 , , , 10_1101-2020_03_27_012757 694 4 43–49 43–49 CD 10_1101-2020_03_27_012757 694 5 ( ( -LRB- 10_1101-2020_03_27_012757 694 6 2013 2013 CD 10_1101-2020_03_27_012757 694 7 ) ) -RRB- 10_1101-2020_03_27_012757 694 8 . . . 10_1101-2020_03_27_012757 695 1 1065 1065 CD 10_1101-2020_03_27_012757 695 2 34 34 CD 10_1101-2020_03_27_012757 695 3 . . . 10_1101-2020_03_27_012757 696 1 Verhaak Verhaak NNP 10_1101-2020_03_27_012757 696 2 , , , 10_1101-2020_03_27_012757 696 3 R. R. NNP 10_1101-2020_03_27_012757 696 4 G. G. NNP 10_1101-2020_03_27_012757 696 5 W. W. NNP 10_1101-2020_03_27_012757 696 6 et et NNP 10_1101-2020_03_27_012757 696 7 al al NNP 10_1101-2020_03_27_012757 696 8 . . . 10_1101-2020_03_27_012757 697 1 Integrated integrate VBN 10_1101-2020_03_27_012757 697 2 genomic genomic JJ 10_1101-2020_03_27_012757 697 3 analysis analysis NN 10_1101-2020_03_27_012757 697 4 identifies identifie NNS 10_1101-2020_03_27_012757 697 5 clinically clinically RB 10_1101-2020_03_27_012757 697 6 relevant relevant JJ 10_1101-2020_03_27_012757 697 7 1066 1066 CD 10_1101-2020_03_27_012757 697 8 subtypes subtype NNS 10_1101-2020_03_27_012757 697 9 of of IN 10_1101-2020_03_27_012757 697 10 glioblastoma glioblastoma NNP 10_1101-2020_03_27_012757 697 11 characterized characterize VBN 10_1101-2020_03_27_012757 697 12 by by IN 10_1101-2020_03_27_012757 697 13 abnormalities abnormality NNS 10_1101-2020_03_27_012757 697 14 in in IN 10_1101-2020_03_27_012757 697 15 PDGFRA PDGFRA NNP 10_1101-2020_03_27_012757 697 16 , , , 10_1101-2020_03_27_012757 697 17 IDH1 IDH1 NNP 10_1101-2020_03_27_012757 697 18 , , , 10_1101-2020_03_27_012757 697 19 EGFR EGFR NNP 10_1101-2020_03_27_012757 697 20 , , , 10_1101-2020_03_27_012757 697 21 1067 1067 CD 10_1101-2020_03_27_012757 697 22 and and CC 10_1101-2020_03_27_012757 697 23 NF1 NF1 NNP 10_1101-2020_03_27_012757 697 24 . . . 10_1101-2020_03_27_012757 698 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 698 2 Cell Cell NNP 10_1101-2020_03_27_012757 698 3 17 17 CD 10_1101-2020_03_27_012757 698 4 , , , 10_1101-2020_03_27_012757 698 5 98–110 98–110 CD 10_1101-2020_03_27_012757 698 6 ( ( -LRB- 10_1101-2020_03_27_012757 698 7 2010 2010 CD 10_1101-2020_03_27_012757 698 8 ) ) -RRB- 10_1101-2020_03_27_012757 698 9 . . . 10_1101-2020_03_27_012757 699 1 1068 1068 CD 10_1101-2020_03_27_012757 699 2 35 35 CD 10_1101-2020_03_27_012757 699 3 . . . 10_1101-2020_03_27_012757 700 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 700 2 Genome Genome NNP 10_1101-2020_03_27_012757 700 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 700 4 Research Research NNP 10_1101-2020_03_27_012757 700 5 Network Network NNP 10_1101-2020_03_27_012757 700 6 . . . 10_1101-2020_03_27_012757 701 1 Comprehensive comprehensive JJ 10_1101-2020_03_27_012757 701 2 molecular molecular JJ 10_1101-2020_03_27_012757 701 3 profiling profiling NN 10_1101-2020_03_27_012757 701 4 of of IN 10_1101-2020_03_27_012757 701 5 1069 1069 CD 10_1101-2020_03_27_012757 701 6 lung lung NN 10_1101-2020_03_27_012757 701 7 adenocarcinoma adenocarcinoma NNP 10_1101-2020_03_27_012757 701 8 . . . 10_1101-2020_03_27_012757 702 1 Nature nature NN 10_1101-2020_03_27_012757 702 2 511 511 CD 10_1101-2020_03_27_012757 702 3 , , , 10_1101-2020_03_27_012757 702 4 543–550 543–550 CD 10_1101-2020_03_27_012757 702 5 ( ( -LRB- 10_1101-2020_03_27_012757 702 6 2014 2014 CD 10_1101-2020_03_27_012757 702 7 ) ) -RRB- 10_1101-2020_03_27_012757 702 8 . . . 10_1101-2020_03_27_012757 703 1 1070 1070 CD 10_1101-2020_03_27_012757 703 2 36 36 CD 10_1101-2020_03_27_012757 703 3 . . . 10_1101-2020_03_27_012757 704 1 Hu Hu NNP 10_1101-2020_03_27_012757 704 2 , , , 10_1101-2020_03_27_012757 704 3 B. B. NNP 10_1101-2020_03_27_012757 704 4 et et NNP 10_1101-2020_03_27_012757 704 5 al al NNP 10_1101-2020_03_27_012757 704 6 . . . 10_1101-2020_03_27_012757 705 1 Gastric gastric JJ 10_1101-2020_03_27_012757 705 2 cancer cancer NN 10_1101-2020_03_27_012757 705 3 : : : 10_1101-2020_03_27_012757 705 4 Classification classification NN 10_1101-2020_03_27_012757 705 5 , , , 10_1101-2020_03_27_012757 705 6 histology histology NN 10_1101-2020_03_27_012757 705 7 and and CC 10_1101-2020_03_27_012757 705 8 application application NN 10_1101-2020_03_27_012757 705 9 of of IN 10_1101-2020_03_27_012757 705 10 molecular molecular JJ 10_1101-2020_03_27_012757 705 11 1071 1071 CD 10_1101-2020_03_27_012757 705 12 pathology pathology NN 10_1101-2020_03_27_012757 705 13 . . . 10_1101-2020_03_27_012757 706 1 J. J. NNP 10_1101-2020_03_27_012757 706 2 Gastrointest Gastrointest NNP 10_1101-2020_03_27_012757 706 3 . . . 10_1101-2020_03_27_012757 707 1 Oncol Oncol NNP 10_1101-2020_03_27_012757 707 2 . . . 10_1101-2020_03_27_012757 708 1 3 3 CD 10_1101-2020_03_27_012757 708 2 , , , 10_1101-2020_03_27_012757 708 3 251–261 251–261 CD 10_1101-2020_03_27_012757 708 4 ( ( -LRB- 10_1101-2020_03_27_012757 708 5 2012 2012 CD 10_1101-2020_03_27_012757 708 6 ) ) -RRB- 10_1101-2020_03_27_012757 708 7 . . . 10_1101-2020_03_27_012757 709 1 1072 1072 CD 10_1101-2020_03_27_012757 709 2 37 37 CD 10_1101-2020_03_27_012757 709 3 . . . 10_1101-2020_03_27_012757 710 1 Barretina Barretina NNP 10_1101-2020_03_27_012757 710 2 , , , 10_1101-2020_03_27_012757 710 3 J. J. NNP 10_1101-2020_03_27_012757 710 4 et et NNP 10_1101-2020_03_27_012757 710 5 al al NNP 10_1101-2020_03_27_012757 710 6 . . . 10_1101-2020_03_27_012757 711 1 The the DT 10_1101-2020_03_27_012757 711 2 Cancer Cancer NNP 10_1101-2020_03_27_012757 711 3 Cell Cell NNP 10_1101-2020_03_27_012757 711 4 Line Line NNP 10_1101-2020_03_27_012757 711 5 Encyclopedia Encyclopedia NNP 10_1101-2020_03_27_012757 711 6 enables enable VBZ 10_1101-2020_03_27_012757 711 7 predictive predictive JJ 10_1101-2020_03_27_012757 711 8 modelling modelling NN 10_1101-2020_03_27_012757 711 9 1073 1073 CD 10_1101-2020_03_27_012757 711 10 of of IN 10_1101-2020_03_27_012757 711 11 anticancer anticancer NN 10_1101-2020_03_27_012757 711 12 drug drug NN 10_1101-2020_03_27_012757 711 13 sensitivity sensitivity NN 10_1101-2020_03_27_012757 711 14 . . . 10_1101-2020_03_27_012757 712 1 Nature nature NN 10_1101-2020_03_27_012757 712 2 483 483 CD 10_1101-2020_03_27_012757 712 3 , , , 10_1101-2020_03_27_012757 712 4 603–607 603–607 CD 10_1101-2020_03_27_012757 712 5 ( ( -LRB- 10_1101-2020_03_27_012757 712 6 2012 2012 CD 10_1101-2020_03_27_012757 712 7 ) ) -RRB- 10_1101-2020_03_27_012757 712 8 . . . 10_1101-2020_03_27_012757 713 1 1074 1074 CD 10_1101-2020_03_27_012757 713 2 38 38 CD 10_1101-2020_03_27_012757 713 3 . . . 10_1101-2020_03_27_012757 714 1 Medico Medico NNP 10_1101-2020_03_27_012757 714 2 , , , 10_1101-2020_03_27_012757 714 3 E. E. NNP 10_1101-2020_03_27_012757 714 4 et et NNP 10_1101-2020_03_27_012757 714 5 al al NNP 10_1101-2020_03_27_012757 714 6 . . . 10_1101-2020_03_27_012757 715 1 The the DT 10_1101-2020_03_27_012757 715 2 molecular molecular JJ 10_1101-2020_03_27_012757 715 3 landscape landscape NN 10_1101-2020_03_27_012757 715 4 of of IN 10_1101-2020_03_27_012757 715 5 colorectal colorectal JJ 10_1101-2020_03_27_012757 715 6 cancer cancer NN 10_1101-2020_03_27_012757 715 7 cell cell NN 10_1101-2020_03_27_012757 715 8 lines line NNS 10_1101-2020_03_27_012757 715 9 unveils unveil NNS 10_1101-2020_03_27_012757 715 10 1075 1075 CD 10_1101-2020_03_27_012757 715 11 clinically clinically RB 10_1101-2020_03_27_012757 715 12 actionable actionable JJ 10_1101-2020_03_27_012757 715 13 kinase kinase NN 10_1101-2020_03_27_012757 715 14 targets target NNS 10_1101-2020_03_27_012757 715 15 . . . 10_1101-2020_03_27_012757 716 1 Nat Nat NNP 10_1101-2020_03_27_012757 716 2 . . . 10_1101-2020_03_27_012757 717 1 Commun Commun VBN 10_1101-2020_03_27_012757 717 2 . . . 10_1101-2020_03_27_012757 718 1 6 6 CD 10_1101-2020_03_27_012757 718 2 , , , 10_1101-2020_03_27_012757 718 3 7002 7002 CD 10_1101-2020_03_27_012757 718 4 ( ( -LRB- 10_1101-2020_03_27_012757 718 5 2015 2015 CD 10_1101-2020_03_27_012757 718 6 ) ) -RRB- 10_1101-2020_03_27_012757 718 7 . . . 10_1101-2020_03_27_012757 719 1 1076 1076 CD 10_1101-2020_03_27_012757 719 2 39 39 CD 10_1101-2020_03_27_012757 719 3 . . . 10_1101-2020_03_27_012757 720 1 Park Park NNP 10_1101-2020_03_27_012757 720 2 , , , 10_1101-2020_03_27_012757 720 3 J.-G. J.-G. NNP 10_1101-2020_03_27_012757 720 4 et et NNP 10_1101-2020_03_27_012757 720 5 al al NNP 10_1101-2020_03_27_012757 720 6 . . . 10_1101-2020_03_27_012757 721 1 Characteristics Characteristics NNP 10_1101-2020_03_27_012757 721 2 of of IN 10_1101-2020_03_27_012757 721 3 Cell Cell NNP 10_1101-2020_03_27_012757 721 4 Lines Lines NNPS 10_1101-2020_03_27_012757 721 5 Established establish VBN 10_1101-2020_03_27_012757 721 6 from from IN 10_1101-2020_03_27_012757 721 7 Human Human NNP 10_1101-2020_03_27_012757 721 8 Colorectal Colorectal NNP 10_1101-2020_03_27_012757 721 9 1077 1077 CD 10_1101-2020_03_27_012757 721 10 Carcinoma Carcinoma NNP 10_1101-2020_03_27_012757 721 11 . . . 10_1101-2020_03_27_012757 722 1 Cancer cancer NN 10_1101-2020_03_27_012757 722 2 Res Res NNP 10_1101-2020_03_27_012757 722 3 . . . 10_1101-2020_03_27_012757 723 1 ( ( -LRB- 10_1101-2020_03_27_012757 723 2 1987 1987 CD 10_1101-2020_03_27_012757 723 3 ) ) -RRB- 10_1101-2020_03_27_012757 723 4 . . . 10_1101-2020_03_27_012757 724 1 1078 1078 CD 10_1101-2020_03_27_012757 724 2 40 40 CD 10_1101-2020_03_27_012757 724 3 . . . 10_1101-2020_03_27_012757 725 1 Jerby Jerby NNP 10_1101-2020_03_27_012757 725 2 - - HYPH 10_1101-2020_03_27_012757 725 3 Arnon Arnon NNP 10_1101-2020_03_27_012757 725 4 , , , 10_1101-2020_03_27_012757 725 5 L. L. NNP 10_1101-2020_03_27_012757 725 6 et et NNP 10_1101-2020_03_27_012757 725 7 al al NNP 10_1101-2020_03_27_012757 725 8 . . . 10_1101-2020_03_27_012757 726 1 A a DT 10_1101-2020_03_27_012757 726 2 cancer cancer NN 10_1101-2020_03_27_012757 726 3 cell cell NN 10_1101-2020_03_27_012757 726 4 program program NN 10_1101-2020_03_27_012757 726 5 promotes promote VBZ 10_1101-2020_03_27_012757 726 6 T T NNP 10_1101-2020_03_27_012757 726 7 cell cell NN 10_1101-2020_03_27_012757 726 8 exclusion exclusion NN 10_1101-2020_03_27_012757 726 9 and and CC 10_1101-2020_03_27_012757 726 10 1079 1079 CD 10_1101-2020_03_27_012757 726 11 resistance resistance NN 10_1101-2020_03_27_012757 726 12 to to IN 10_1101-2020_03_27_012757 726 13 checkpoint checkpoint JJ 10_1101-2020_03_27_012757 726 14 blockade blockade NN 10_1101-2020_03_27_012757 726 15 . . . 10_1101-2020_03_27_012757 727 1 Cell cell NN 10_1101-2020_03_27_012757 727 2 175 175 CD 10_1101-2020_03_27_012757 727 3 , , , 10_1101-2020_03_27_012757 727 4 984–997.e24 984–997.e24 CD 10_1101-2020_03_27_012757 727 5 ( ( -LRB- 10_1101-2020_03_27_012757 727 6 2018 2018 CD 10_1101-2020_03_27_012757 727 7 ) ) -RRB- 10_1101-2020_03_27_012757 727 8 . . . 10_1101-2020_03_27_012757 728 1 1080 1080 CD 10_1101-2020_03_27_012757 728 2 41 41 CD 10_1101-2020_03_27_012757 728 3 . . . 10_1101-2020_03_27_012757 729 1 Darmanis Darmanis NNP 10_1101-2020_03_27_012757 729 2 , , , 10_1101-2020_03_27_012757 729 3 S. S. NNP 10_1101-2020_03_27_012757 729 4 et et NNP 10_1101-2020_03_27_012757 729 5 al al NNP 10_1101-2020_03_27_012757 729 6 . . . 10_1101-2020_03_27_012757 730 1 Single single JJ 10_1101-2020_03_27_012757 730 2 - - HYPH 10_1101-2020_03_27_012757 730 3 Cell Cell NNP 10_1101-2020_03_27_012757 730 4 RNA RNA NNP 10_1101-2020_03_27_012757 730 5 - - HYPH 10_1101-2020_03_27_012757 730 6 Seq Seq NNP 10_1101-2020_03_27_012757 730 7 Analysis Analysis NNP 10_1101-2020_03_27_012757 730 8 of of IN 10_1101-2020_03_27_012757 730 9 Infiltrating infiltrate VBG 10_1101-2020_03_27_012757 730 10 Neoplastic neoplastic JJ 10_1101-2020_03_27_012757 730 11 Cells cell NNS 10_1101-2020_03_27_012757 730 12 at at IN 10_1101-2020_03_27_012757 730 13 1081 1081 CD 10_1101-2020_03_27_012757 730 14 the the DT 10_1101-2020_03_27_012757 730 15 Migrating Migrating NNP 10_1101-2020_03_27_012757 730 16 Front Front NNP 10_1101-2020_03_27_012757 730 17 of of IN 10_1101-2020_03_27_012757 730 18 Human Human NNP 10_1101-2020_03_27_012757 730 19 Glioblastoma Glioblastoma NNP 10_1101-2020_03_27_012757 730 20 . . . 10_1101-2020_03_27_012757 731 1 Cell Cell NNP 10_1101-2020_03_27_012757 731 2 Rep. Rep. NNP 10_1101-2020_03_27_012757 731 3 21 21 CD 10_1101-2020_03_27_012757 731 4 , , , 10_1101-2020_03_27_012757 731 5 1399–1410 1399–1410 CD 10_1101-2020_03_27_012757 731 6 ( ( -LRB- 10_1101-2020_03_27_012757 731 7 2017 2017 CD 10_1101-2020_03_27_012757 731 8 ) ) -RRB- 10_1101-2020_03_27_012757 731 9 . . . 10_1101-2020_03_27_012757 732 1 1082 1082 CD 10_1101-2020_03_27_012757 732 2 42 42 CD 10_1101-2020_03_27_012757 732 3 . . . 10_1101-2020_03_27_012757 733 1 Patel Patel NNP 10_1101-2020_03_27_012757 733 2 , , , 10_1101-2020_03_27_012757 733 3 A. A. NNP 10_1101-2020_03_27_012757 733 4 P. P. NNP 10_1101-2020_03_27_012757 733 5 et et NNP 10_1101-2020_03_27_012757 733 6 al al NNP 10_1101-2020_03_27_012757 733 7 . . . 10_1101-2020_03_27_012757 734 1 Single single JJ 10_1101-2020_03_27_012757 734 2 - - HYPH 10_1101-2020_03_27_012757 734 3 cell cell NN 10_1101-2020_03_27_012757 734 4 RNA RNA NNP 10_1101-2020_03_27_012757 734 5 - - HYPH 10_1101-2020_03_27_012757 734 6 seq seq NN 10_1101-2020_03_27_012757 734 7 highlights highlight NNS 10_1101-2020_03_27_012757 734 8 intratumoral intratumoral JJ 10_1101-2020_03_27_012757 734 9 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 734 10 in in IN 10_1101-2020_03_27_012757 734 11 1083 1083 CD 10_1101-2020_03_27_012757 734 12 primary primary JJ 10_1101-2020_03_27_012757 734 13 glioblastoma glioblastoma NN 10_1101-2020_03_27_012757 734 14 . . . 10_1101-2020_03_27_012757 735 1 Science science NN 10_1101-2020_03_27_012757 735 2 344 344 CD 10_1101-2020_03_27_012757 735 3 , , , 10_1101-2020_03_27_012757 735 4 1396–1401 1396–1401 CD 10_1101-2020_03_27_012757 735 5 ( ( -LRB- 10_1101-2020_03_27_012757 735 6 2014 2014 CD 10_1101-2020_03_27_012757 735 7 ) ) -RRB- 10_1101-2020_03_27_012757 735 8 . . . 10_1101-2020_03_27_012757 736 1 1084 1084 CD 10_1101-2020_03_27_012757 736 2 43 43 CD 10_1101-2020_03_27_012757 736 3 . . . 10_1101-2020_03_27_012757 737 1 Xu Xu NNP 10_1101-2020_03_27_012757 737 2 , , , 10_1101-2020_03_27_012757 737 3 B. B. NNP 10_1101-2020_03_27_012757 737 4 et et NNP 10_1101-2020_03_27_012757 737 5 al al NNP 10_1101-2020_03_27_012757 737 6 . . . 10_1101-2020_03_27_012757 738 1 Regulation regulation NN 10_1101-2020_03_27_012757 738 2 of of IN 10_1101-2020_03_27_012757 738 3 endometrial endometrial JJ 10_1101-2020_03_27_012757 738 4 receptivity receptivity NN 10_1101-2020_03_27_012757 738 5 by by IN 10_1101-2020_03_27_012757 738 6 the the DT 10_1101-2020_03_27_012757 738 7 highly highly RB 10_1101-2020_03_27_012757 738 8 expressed express VBN 10_1101-2020_03_27_012757 738 9 HOXA9 hoxa9 NN 10_1101-2020_03_27_012757 738 10 , , , 10_1101-2020_03_27_012757 738 11 1085 1085 CD 10_1101-2020_03_27_012757 738 12 HOXA11 HOXA11 NNP 10_1101-2020_03_27_012757 738 13 and and CC 10_1101-2020_03_27_012757 738 14 HOXD10 HOXD10 NNP 10_1101-2020_03_27_012757 738 15 HOX HOX NNP 10_1101-2020_03_27_012757 738 16 - - HYPH 10_1101-2020_03_27_012757 738 17 class class NN 10_1101-2020_03_27_012757 738 18 homeobox homeobox NN 10_1101-2020_03_27_012757 738 19 genes gene NNS 10_1101-2020_03_27_012757 738 20 . . . 10_1101-2020_03_27_012757 739 1 Hum hum UH 10_1101-2020_03_27_012757 739 2 . . . 10_1101-2020_03_27_012757 740 1 Reprod Reprod NNP 10_1101-2020_03_27_012757 740 2 . . . 10_1101-2020_03_27_012757 741 1 29 29 CD 10_1101-2020_03_27_012757 741 2 , , , 10_1101-2020_03_27_012757 741 3 781–790 781–790 CD 10_1101-2020_03_27_012757 741 4 1086 1086 CD 10_1101-2020_03_27_012757 741 5 ( ( -LRB- 10_1101-2020_03_27_012757 741 6 2014 2014 CD 10_1101-2020_03_27_012757 741 7 ) ) -RRB- 10_1101-2020_03_27_012757 741 8 . . . 10_1101-2020_03_27_012757 742 1 1087 1087 CD 10_1101-2020_03_27_012757 742 2 44 44 CD 10_1101-2020_03_27_012757 742 3 . . . 10_1101-2020_03_27_012757 743 1 Raines Raines NNP 10_1101-2020_03_27_012757 743 2 , , , 10_1101-2020_03_27_012757 743 3 A. A. NNP 10_1101-2020_03_27_012757 743 4 M. M. NNP 10_1101-2020_03_27_012757 743 5 et et NNP 10_1101-2020_03_27_012757 743 6 al al NNP 10_1101-2020_03_27_012757 743 7 . . . 10_1101-2020_03_27_012757 744 1 Recombineering recombineere VBG 10_1101-2020_03_27_012757 744 2 - - HYPH 10_1101-2020_03_27_012757 744 3 based base VBN 10_1101-2020_03_27_012757 744 4 dissection dissection NN 10_1101-2020_03_27_012757 744 5 of of IN 10_1101-2020_03_27_012757 744 6 flanking flanking NN 10_1101-2020_03_27_012757 744 7 and and CC 10_1101-2020_03_27_012757 744 8 paralogous paralogous JJ 10_1101-2020_03_27_012757 744 9 1088 1088 CD 10_1101-2020_03_27_012757 744 10 Hox Hox NNP 10_1101-2020_03_27_012757 744 11 gene gene NN 10_1101-2020_03_27_012757 744 12 functions function NNS 10_1101-2020_03_27_012757 744 13 in in IN 10_1101-2020_03_27_012757 744 14 mouse mouse NN 10_1101-2020_03_27_012757 744 15 reproductive reproductive NNP 10_1101-2020_03_27_012757 744 16 tracts tract NNS 10_1101-2020_03_27_012757 744 17 . . . 10_1101-2020_03_27_012757 745 1 Development development NN 10_1101-2020_03_27_012757 745 2 140 140 CD 10_1101-2020_03_27_012757 745 3 , , , 10_1101-2020_03_27_012757 745 4 2942–2952 2942–2952 CD 10_1101-2020_03_27_012757 745 5 1089 1089 CD 10_1101-2020_03_27_012757 745 6 ( ( -LRB- 10_1101-2020_03_27_012757 745 7 2013 2013 CD 10_1101-2020_03_27_012757 745 8 ) ) -RRB- 10_1101-2020_03_27_012757 745 9 . . . 10_1101-2020_03_27_012757 746 1 1090 1090 CD 10_1101-2020_03_27_012757 746 2 45 45 CD 10_1101-2020_03_27_012757 746 3 . . . 10_1101-2020_03_27_012757 747 1 Netinatsunthorn Netinatsunthorn NNP 10_1101-2020_03_27_012757 747 2 , , , 10_1101-2020_03_27_012757 747 3 W. W. NNP 10_1101-2020_03_27_012757 747 4 , , , 10_1101-2020_03_27_012757 747 5 Hanprasertpong Hanprasertpong NNP 10_1101-2020_03_27_012757 747 6 , , , 10_1101-2020_03_27_012757 747 7 J. J. NNP 10_1101-2020_03_27_012757 747 8 , , , 10_1101-2020_03_27_012757 747 9 Dechsukhum Dechsukhum NNP 10_1101-2020_03_27_012757 747 10 , , , 10_1101-2020_03_27_012757 747 11 C. C. NNP 10_1101-2020_03_27_012757 747 12 , , , 10_1101-2020_03_27_012757 747 13 Leetanaporn Leetanaporn NNP 10_1101-2020_03_27_012757 747 14 , , , 10_1101-2020_03_27_012757 747 15 R. R. NNP 10_1101-2020_03_27_012757 747 16 & & CC 10_1101-2020_03_27_012757 747 17 1091 1091 CD 10_1101-2020_03_27_012757 747 18 Geater Geater NNP 10_1101-2020_03_27_012757 747 19 , , , 10_1101-2020_03_27_012757 747 20 A. a. NN 10_1101-2020_03_27_012757 747 21 WT1 WT1 NNP 10_1101-2020_03_27_012757 747 22 gene gene NN 10_1101-2020_03_27_012757 747 23 expression expression NN 10_1101-2020_03_27_012757 747 24 as as IN 10_1101-2020_03_27_012757 747 25 a a DT 10_1101-2020_03_27_012757 747 26 prognostic prognostic JJ 10_1101-2020_03_27_012757 747 27 marker marker NN 10_1101-2020_03_27_012757 747 28 in in IN 10_1101-2020_03_27_012757 747 29 advanced advanced JJ 10_1101-2020_03_27_012757 747 30 serous serous JJ 10_1101-2020_03_27_012757 747 31 1092 1092 CD 10_1101-2020_03_27_012757 747 32 epithelial epithelial JJ 10_1101-2020_03_27_012757 747 33 ovarian ovarian JJ 10_1101-2020_03_27_012757 747 34 carcinoma carcinoma NN 10_1101-2020_03_27_012757 747 35 : : : 10_1101-2020_03_27_012757 747 36 an an DT 10_1101-2020_03_27_012757 747 37 immunohistochemical immunohistochemical JJ 10_1101-2020_03_27_012757 747 38 study study NN 10_1101-2020_03_27_012757 747 39 . . . 10_1101-2020_03_27_012757 748 1 BMC BMC NNP 10_1101-2020_03_27_012757 748 2 Cancer Cancer NNP 10_1101-2020_03_27_012757 748 3 6 6 CD 10_1101-2020_03_27_012757 748 4 , , , 10_1101-2020_03_27_012757 748 5 90 90 CD 10_1101-2020_03_27_012757 748 6 1093 1093 CD 10_1101-2020_03_27_012757 748 7 ( ( -LRB- 10_1101-2020_03_27_012757 748 8 2006 2006 CD 10_1101-2020_03_27_012757 748 9 ) ) -RRB- 10_1101-2020_03_27_012757 748 10 . . . 10_1101-2020_03_27_012757 749 1 1094 1094 CD 10_1101-2020_03_27_012757 749 2 46 46 CD 10_1101-2020_03_27_012757 749 3 . . . 10_1101-2020_03_27_012757 750 1 Kelly Kelly NNP 10_1101-2020_03_27_012757 750 2 , , , 10_1101-2020_03_27_012757 750 3 Z. Z. NNP 10_1101-2020_03_27_012757 750 4 et et FW 10_1101-2020_03_27_012757 750 5 al al NNP 10_1101-2020_03_27_012757 750 6 . . . 10_1101-2020_03_27_012757 751 1 The the DT 10_1101-2020_03_27_012757 751 2 prognostic prognostic JJ 10_1101-2020_03_27_012757 751 3 significance significance NN 10_1101-2020_03_27_012757 751 4 of of IN 10_1101-2020_03_27_012757 751 5 specific specific JJ 10_1101-2020_03_27_012757 751 6 HOX HOX NNP 10_1101-2020_03_27_012757 751 7 gene gene NN 10_1101-2020_03_27_012757 751 8 expression expression NN 10_1101-2020_03_27_012757 751 9 patterns pattern NNS 10_1101-2020_03_27_012757 751 10 1095 1095 CD 10_1101-2020_03_27_012757 751 11 in in IN 10_1101-2020_03_27_012757 751 12 ovarian ovarian JJ 10_1101-2020_03_27_012757 751 13 cancer cancer NN 10_1101-2020_03_27_012757 751 14 . . . 10_1101-2020_03_27_012757 752 1 Int Int NNP 10_1101-2020_03_27_012757 752 2 . . . 10_1101-2020_03_27_012757 753 1 J. J. NNP 10_1101-2020_03_27_012757 754 1 Cancer cancer NN 10_1101-2020_03_27_012757 754 2 139 139 CD 10_1101-2020_03_27_012757 754 3 , , , 10_1101-2020_03_27_012757 754 4 1608–1617 1608–1617 CD 10_1101-2020_03_27_012757 754 5 ( ( -LRB- 10_1101-2020_03_27_012757 754 6 2016 2016 CD 10_1101-2020_03_27_012757 754 7 ) ) -RRB- 10_1101-2020_03_27_012757 754 8 . . . 10_1101-2020_03_27_012757 755 1 1096 1096 CD 10_1101-2020_03_27_012757 755 2 .CC .CC : 10_1101-2020_03_27_012757 755 3 - - : 10_1101-2020_03_27_012757 755 4 BY by IN 10_1101-2020_03_27_012757 755 5 - - HYPH 10_1101-2020_03_27_012757 755 6 NC NC NNP 10_1101-2020_03_27_012757 755 7 - - HYPH 10_1101-2020_03_27_012757 755 8 ND ND NNP 10_1101-2020_03_27_012757 755 9 4.0 4.0 CD 10_1101-2020_03_27_012757 755 10 International International NNP 10_1101-2020_03_27_012757 755 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 755 12 under under IN 10_1101-2020_03_27_012757 755 13 a a DT 10_1101-2020_03_27_012757 755 14 ( ( -LRB- 10_1101-2020_03_27_012757 755 15 which which WDT 10_1101-2020_03_27_012757 755 16 was be VBD 10_1101-2020_03_27_012757 755 17 not not RB 10_1101-2020_03_27_012757 755 18 certified certify VBN 10_1101-2020_03_27_012757 755 19 by by IN 10_1101-2020_03_27_012757 755 20 peer peer NN 10_1101-2020_03_27_012757 755 21 review review NN 10_1101-2020_03_27_012757 755 22 ) ) -RRB- 10_1101-2020_03_27_012757 755 23 is be VBZ 10_1101-2020_03_27_012757 755 24 the the DT 10_1101-2020_03_27_012757 755 25 author author NN 10_1101-2020_03_27_012757 755 26 / / SYM 10_1101-2020_03_27_012757 755 27 funder funder NN 10_1101-2020_03_27_012757 755 28 , , , 10_1101-2020_03_27_012757 755 29 who who WP 10_1101-2020_03_27_012757 755 30 has have VBZ 10_1101-2020_03_27_012757 755 31 granted grant VBN 10_1101-2020_03_27_012757 755 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 755 33 a a DT 10_1101-2020_03_27_012757 755 34 license license NN 10_1101-2020_03_27_012757 755 35 to to TO 10_1101-2020_03_27_012757 755 36 display display VB 10_1101-2020_03_27_012757 755 37 the the DT 10_1101-2020_03_27_012757 755 38 preprint preprint NN 10_1101-2020_03_27_012757 755 39 in in IN 10_1101-2020_03_27_012757 755 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 755 41 . . . 10_1101-2020_03_27_012757 756 1 It -PRON- PRP 10_1101-2020_03_27_012757 756 2 is be VBZ 10_1101-2020_03_27_012757 756 3 made make VBN 10_1101-2020_03_27_012757 756 4 The the DT 10_1101-2020_03_27_012757 756 5 copyright copyright NN 10_1101-2020_03_27_012757 756 6 holder holder NN 10_1101-2020_03_27_012757 756 7 for for IN 10_1101-2020_03_27_012757 756 8 this this DT 10_1101-2020_03_27_012757 756 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 756 10 version version NN 10_1101-2020_03_27_012757 756 11 posted post VBD 10_1101-2020_03_27_012757 756 12 January January NNP 10_1101-2020_03_27_012757 756 13 9 9 CD 10_1101-2020_03_27_012757 756 14 , , , 10_1101-2020_03_27_012757 756 15 2021 2021 CD 10_1101-2020_03_27_012757 756 16 . . . 10_1101-2020_03_27_012757 756 17 ; ; : 10_1101-2020_03_27_012757 756 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 756 19 : : : 10_1101-2020_03_27_012757 756 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 756 21 preprint preprint NN 10_1101-2020_03_27_012757 756 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 756 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 756 24 40 40 CD 10_1101-2020_03_27_012757 756 25 47 47 CD 10_1101-2020_03_27_012757 756 26 . . . 10_1101-2020_03_27_012757 757 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 757 2 Genome Genome NNP 10_1101-2020_03_27_012757 757 3 Atlas Atlas NNP 10_1101-2020_03_27_012757 757 4 Research Research NNP 10_1101-2020_03_27_012757 757 5 Network Network NNP 10_1101-2020_03_27_012757 757 6 . . . 10_1101-2020_03_27_012757 758 1 Integrated integrate VBN 10_1101-2020_03_27_012757 758 2 genomic genomic JJ 10_1101-2020_03_27_012757 758 3 analyses analysis NNS 10_1101-2020_03_27_012757 758 4 of of IN 10_1101-2020_03_27_012757 758 5 ovarian ovarian JJ 10_1101-2020_03_27_012757 758 6 1097 1097 CD 10_1101-2020_03_27_012757 758 7 carcinoma carcinoma NN 10_1101-2020_03_27_012757 758 8 . . . 10_1101-2020_03_27_012757 759 1 Nature nature NN 10_1101-2020_03_27_012757 759 2 474 474 CD 10_1101-2020_03_27_012757 759 3 , , , 10_1101-2020_03_27_012757 759 4 609–615 609–615 CD 10_1101-2020_03_27_012757 759 5 ( ( -LRB- 10_1101-2020_03_27_012757 759 6 2011 2011 CD 10_1101-2020_03_27_012757 759 7 ) ) -RRB- 10_1101-2020_03_27_012757 759 8 . . . 10_1101-2020_03_27_012757 760 1 1098 1098 CD 10_1101-2020_03_27_012757 760 2 48 48 CD 10_1101-2020_03_27_012757 760 3 . . . 10_1101-2020_03_27_012757 761 1 Wiegand Wiegand NNP 10_1101-2020_03_27_012757 761 2 , , , 10_1101-2020_03_27_012757 761 3 K. K. NNP 10_1101-2020_03_27_012757 761 4 C. C. NNP 10_1101-2020_03_27_012757 761 5 et et NNP 10_1101-2020_03_27_012757 761 6 al al NNP 10_1101-2020_03_27_012757 761 7 . . . 10_1101-2020_03_27_012757 762 1 ARID1A arid1a PRP 10_1101-2020_03_27_012757 762 2 mutations mutation NNS 10_1101-2020_03_27_012757 762 3 in in IN 10_1101-2020_03_27_012757 762 4 endometriosis endometriosis NN 10_1101-2020_03_27_012757 762 5 - - HYPH 10_1101-2020_03_27_012757 762 6 associated associate VBN 10_1101-2020_03_27_012757 762 7 ovarian ovarian NNP 10_1101-2020_03_27_012757 762 8 1099 1099 CD 10_1101-2020_03_27_012757 762 9 carcinomas carcinoma NNS 10_1101-2020_03_27_012757 762 10 . . . 10_1101-2020_03_27_012757 763 1 N. N. NNP 10_1101-2020_03_27_012757 763 2 Engl Engl NNP 10_1101-2020_03_27_012757 763 3 . . . 10_1101-2020_03_27_012757 764 1 J. J. NNP 10_1101-2020_03_27_012757 764 2 Med Med NNP 10_1101-2020_03_27_012757 764 3 . . . 10_1101-2020_03_27_012757 765 1 363 363 CD 10_1101-2020_03_27_012757 765 2 , , , 10_1101-2020_03_27_012757 765 3 1532–1543 1532–1543 CD 10_1101-2020_03_27_012757 765 4 ( ( -LRB- 10_1101-2020_03_27_012757 765 5 2010 2010 CD 10_1101-2020_03_27_012757 765 6 ) ) -RRB- 10_1101-2020_03_27_012757 765 7 . . . 10_1101-2020_03_27_012757 766 1 1100 1100 CD 10_1101-2020_03_27_012757 766 2 49 49 CD 10_1101-2020_03_27_012757 766 3 . . . 10_1101-2020_03_27_012757 767 1 Murray Murray NNP 10_1101-2020_03_27_012757 767 2 , , , 10_1101-2020_03_27_012757 767 3 M. M. NNP 10_1101-2020_03_27_012757 767 4 J. J. NNP 10_1101-2020_03_27_012757 767 5 et et NNP 10_1101-2020_03_27_012757 767 6 al al NNP 10_1101-2020_03_27_012757 767 7 . . . 10_1101-2020_03_27_012757 768 1 LIN28 LIN28 NNP 10_1101-2020_03_27_012757 768 2 Expression expression NN 10_1101-2020_03_27_012757 768 3 in in IN 10_1101-2020_03_27_012757 768 4 malignant malignant JJ 10_1101-2020_03_27_012757 768 5 germ germ NN 10_1101-2020_03_27_012757 768 6 cell cell NN 10_1101-2020_03_27_012757 768 7 tumors tumor NNS 10_1101-2020_03_27_012757 768 8 downregulates downregulate VBZ 10_1101-2020_03_27_012757 768 9 1101 1101 CD 10_1101-2020_03_27_012757 768 10 let-7 let-7 NNP 10_1101-2020_03_27_012757 768 11 and and CC 10_1101-2020_03_27_012757 768 12 increases increase VBZ 10_1101-2020_03_27_012757 768 13 oncogene oncogene NN 10_1101-2020_03_27_012757 768 14 levels level NNS 10_1101-2020_03_27_012757 768 15 . . . 10_1101-2020_03_27_012757 769 1 Cancer cancer NN 10_1101-2020_03_27_012757 769 2 Res Res NNP 10_1101-2020_03_27_012757 769 3 . . . 10_1101-2020_03_27_012757 770 1 73 73 CD 10_1101-2020_03_27_012757 770 2 , , , 10_1101-2020_03_27_012757 770 3 4872–4884 4872–4884 CD 10_1101-2020_03_27_012757 770 4 ( ( -LRB- 10_1101-2020_03_27_012757 770 5 2013 2013 CD 10_1101-2020_03_27_012757 770 6 ) ) -RRB- 10_1101-2020_03_27_012757 770 7 . . . 10_1101-2020_03_27_012757 771 1 1102 1102 CD 10_1101-2020_03_27_012757 771 2 50 50 CD 10_1101-2020_03_27_012757 771 3 . . . 10_1101-2020_03_27_012757 772 1 Biton Biton NNP 10_1101-2020_03_27_012757 772 2 , , , 10_1101-2020_03_27_012757 772 3 A. A. NNP 10_1101-2020_03_27_012757 772 4 et et FW 10_1101-2020_03_27_012757 772 5 al al NNP 10_1101-2020_03_27_012757 772 6 . . . 10_1101-2020_03_27_012757 773 1 Independent independent JJ 10_1101-2020_03_27_012757 773 2 component component NN 10_1101-2020_03_27_012757 773 3 analysis analysis NN 10_1101-2020_03_27_012757 773 4 uncovers uncover NNS 10_1101-2020_03_27_012757 773 5 the the DT 10_1101-2020_03_27_012757 773 6 landscape landscape NN 10_1101-2020_03_27_012757 773 7 of of IN 10_1101-2020_03_27_012757 773 8 the the DT 10_1101-2020_03_27_012757 773 9 1103 1103 CD 10_1101-2020_03_27_012757 773 10 bladder bladder NN 10_1101-2020_03_27_012757 773 11 tumor tumor NN 10_1101-2020_03_27_012757 773 12 transcriptome transcriptome VBN 10_1101-2020_03_27_012757 773 13 and and CC 10_1101-2020_03_27_012757 773 14 reveals reveal VBZ 10_1101-2020_03_27_012757 773 15 insights insight NNS 10_1101-2020_03_27_012757 773 16 into into IN 10_1101-2020_03_27_012757 773 17 luminal luminal JJ 10_1101-2020_03_27_012757 773 18 and and CC 10_1101-2020_03_27_012757 773 19 basal basal NN 10_1101-2020_03_27_012757 773 20 subtypes subtype NNS 10_1101-2020_03_27_012757 773 21 . . . 10_1101-2020_03_27_012757 774 1 1104 1104 CD 10_1101-2020_03_27_012757 774 2 Cell Cell NNP 10_1101-2020_03_27_012757 774 3 Rep. Rep. NNP 10_1101-2020_03_27_012757 774 4 9 9 CD 10_1101-2020_03_27_012757 774 5 , , , 10_1101-2020_03_27_012757 774 6 1235–1245 1235–1245 CD 10_1101-2020_03_27_012757 774 7 ( ( -LRB- 10_1101-2020_03_27_012757 774 8 2014 2014 CD 10_1101-2020_03_27_012757 774 9 ) ) -RRB- 10_1101-2020_03_27_012757 774 10 . . . 10_1101-2020_03_27_012757 775 1 1105 1105 CD 10_1101-2020_03_27_012757 775 2 51 51 CD 10_1101-2020_03_27_012757 775 3 . . . 10_1101-2020_03_27_012757 776 1 Fair Fair NNP 10_1101-2020_03_27_012757 776 2 , , , 10_1101-2020_03_27_012757 776 3 W. W. NNP 10_1101-2020_03_27_012757 776 4 R. R. NNP 10_1101-2020_03_27_012757 776 5 , , , 10_1101-2020_03_27_012757 776 6 Israeli Israeli NNP 10_1101-2020_03_27_012757 776 7 , , , 10_1101-2020_03_27_012757 776 8 R. R. NNP 10_1101-2020_03_27_012757 776 9 S. S. NNP 10_1101-2020_03_27_012757 776 10 & & CC 10_1101-2020_03_27_012757 776 11 Heston Heston NNP 10_1101-2020_03_27_012757 776 12 , , , 10_1101-2020_03_27_012757 776 13 W. W. NNP 10_1101-2020_03_27_012757 776 14 D. D. NNP 10_1101-2020_03_27_012757 776 15 Prostate Prostate NNP 10_1101-2020_03_27_012757 776 16 - - HYPH 10_1101-2020_03_27_012757 776 17 specific specific JJ 10_1101-2020_03_27_012757 776 18 membrane membrane NN 10_1101-2020_03_27_012757 776 19 antigen antigen NN 10_1101-2020_03_27_012757 776 20 . . . 10_1101-2020_03_27_012757 777 1 1106 1106 CD 10_1101-2020_03_27_012757 777 2 Prostate Prostate NNP 10_1101-2020_03_27_012757 777 3 32 32 CD 10_1101-2020_03_27_012757 777 4 , , , 10_1101-2020_03_27_012757 777 5 140–148 140–148 CD 10_1101-2020_03_27_012757 777 6 ( ( -LRB- 10_1101-2020_03_27_012757 777 7 1997 1997 CD 10_1101-2020_03_27_012757 777 8 ) ) -RRB- 10_1101-2020_03_27_012757 777 9 . . . 10_1101-2020_03_27_012757 778 1 1107 1107 CD 10_1101-2020_03_27_012757 778 2 52 52 CD 10_1101-2020_03_27_012757 778 3 . . . 10_1101-2020_03_27_012757 779 1 Black Black NNP 10_1101-2020_03_27_012757 779 2 , , , 10_1101-2020_03_27_012757 779 3 J. J. NNP 10_1101-2020_03_27_012757 779 4 D. D. NNP 10_1101-2020_03_27_012757 779 5 , , , 10_1101-2020_03_27_012757 779 6 English English NNP 10_1101-2020_03_27_012757 779 7 , , , 10_1101-2020_03_27_012757 779 8 D. D. NNP 10_1101-2020_03_27_012757 779 9 P. P. NNP 10_1101-2020_03_27_012757 779 10 , , , 10_1101-2020_03_27_012757 779 11 Roque Roque NNP 10_1101-2020_03_27_012757 779 12 , , , 10_1101-2020_03_27_012757 779 13 D. D. NNP 10_1101-2020_03_27_012757 779 14 M. M. NNP 10_1101-2020_03_27_012757 779 15 & & CC 10_1101-2020_03_27_012757 779 16 Santin Santin NNP 10_1101-2020_03_27_012757 779 17 , , , 10_1101-2020_03_27_012757 779 18 A. a. NN 10_1101-2020_03_27_012757 779 19 D. D. NNP 10_1101-2020_03_27_012757 779 20 Targeted Targeted NNP 10_1101-2020_03_27_012757 779 21 therapy therapy NN 10_1101-2020_03_27_012757 779 22 in in IN 10_1101-2020_03_27_012757 779 23 1108 1108 CD 10_1101-2020_03_27_012757 779 24 uterine uterine JJ 10_1101-2020_03_27_012757 779 25 serous serous JJ 10_1101-2020_03_27_012757 779 26 carcinoma carcinoma NN 10_1101-2020_03_27_012757 779 27 : : : 10_1101-2020_03_27_012757 779 28 an an DT 10_1101-2020_03_27_012757 779 29 aggressive aggressive JJ 10_1101-2020_03_27_012757 779 30 variant variant NN 10_1101-2020_03_27_012757 779 31 of of IN 10_1101-2020_03_27_012757 779 32 endometrial endometrial JJ 10_1101-2020_03_27_012757 779 33 cancer cancer NN 10_1101-2020_03_27_012757 779 34 . . . 10_1101-2020_03_27_012757 780 1 Womens Womens NNP 10_1101-2020_03_27_012757 780 2 1109 1109 CD 10_1101-2020_03_27_012757 780 3 Health Health NNP 10_1101-2020_03_27_012757 780 4 ( ( -LRB- 10_1101-2020_03_27_012757 780 5 Lond Lond NNP 10_1101-2020_03_27_012757 780 6 . . . 10_1101-2020_03_27_012757 781 1 Engl Engl NNP 10_1101-2020_03_27_012757 781 2 . . . 10_1101-2020_03_27_012757 781 3 ) ) -RRB- 10_1101-2020_03_27_012757 782 1 10 10 CD 10_1101-2020_03_27_012757 782 2 , , , 10_1101-2020_03_27_012757 782 3 45–57 45–57 CD 10_1101-2020_03_27_012757 782 4 ( ( -LRB- 10_1101-2020_03_27_012757 782 5 2014 2014 CD 10_1101-2020_03_27_012757 782 6 ) ) -RRB- 10_1101-2020_03_27_012757 782 7 . . . 10_1101-2020_03_27_012757 783 1 1110 1110 CD 10_1101-2020_03_27_012757 783 2 53 53 CD 10_1101-2020_03_27_012757 783 3 . . . 10_1101-2020_03_27_012757 784 1 Yang Yang NNP 10_1101-2020_03_27_012757 784 2 , , , 10_1101-2020_03_27_012757 784 3 S. S. NNP 10_1101-2020_03_27_012757 784 4 , , , 10_1101-2020_03_27_012757 784 5 Thiel Thiel NNP 10_1101-2020_03_27_012757 784 6 , , , 10_1101-2020_03_27_012757 784 7 K. K. NNP 10_1101-2020_03_27_012757 784 8 W. W. NNP 10_1101-2020_03_27_012757 784 9 & & CC 10_1101-2020_03_27_012757 784 10 Leslie Leslie NNP 10_1101-2020_03_27_012757 784 11 , , , 10_1101-2020_03_27_012757 784 12 K. K. NNP 10_1101-2020_03_27_012757 784 13 K. K. NNP 10_1101-2020_03_27_012757 784 14 Progesterone Progesterone NNP 10_1101-2020_03_27_012757 784 15 : : : 10_1101-2020_03_27_012757 784 16 the the DT 10_1101-2020_03_27_012757 784 17 ultimate ultimate JJ 10_1101-2020_03_27_012757 784 18 endometrial endometrial JJ 10_1101-2020_03_27_012757 784 19 tumor tumor NN 10_1101-2020_03_27_012757 784 20 1111 1111 CD 10_1101-2020_03_27_012757 784 21 suppressor suppressor NN 10_1101-2020_03_27_012757 784 22 . . . 10_1101-2020_03_27_012757 785 1 Trends Trends NNPS 10_1101-2020_03_27_012757 785 2 Endocrinol Endocrinol NNP 10_1101-2020_03_27_012757 785 3 . . . 10_1101-2020_03_27_012757 786 1 Metab Metab NNP 10_1101-2020_03_27_012757 786 2 . . . 10_1101-2020_03_27_012757 787 1 22 22 CD 10_1101-2020_03_27_012757 787 2 , , , 10_1101-2020_03_27_012757 787 3 145–152 145–152 CD 10_1101-2020_03_27_012757 787 4 ( ( -LRB- 10_1101-2020_03_27_012757 787 5 2011 2011 CD 10_1101-2020_03_27_012757 787 6 ) ) -RRB- 10_1101-2020_03_27_012757 787 7 . . . 10_1101-2020_03_27_012757 788 1 1112 1112 CD 10_1101-2020_03_27_012757 788 2 54 54 CD 10_1101-2020_03_27_012757 788 3 . . . 10_1101-2020_03_27_012757 789 1 Huszar Huszar NNP 10_1101-2020_03_27_012757 789 2 , , , 10_1101-2020_03_27_012757 789 3 M. M. NNP 10_1101-2020_03_27_012757 789 4 et et NNP 10_1101-2020_03_27_012757 789 5 al al NNP 10_1101-2020_03_27_012757 789 6 . . . 10_1101-2020_03_27_012757 790 1 Up up IN 10_1101-2020_03_27_012757 790 2 - - HYPH 10_1101-2020_03_27_012757 790 3 regulation regulation NN 10_1101-2020_03_27_012757 790 4 of of IN 10_1101-2020_03_27_012757 790 5 L1CAM L1CAM NNP 10_1101-2020_03_27_012757 790 6 is be VBZ 10_1101-2020_03_27_012757 790 7 linked link VBN 10_1101-2020_03_27_012757 790 8 to to IN 10_1101-2020_03_27_012757 790 9 loss loss NN 10_1101-2020_03_27_012757 790 10 of of IN 10_1101-2020_03_27_012757 790 11 hormone hormone NN 10_1101-2020_03_27_012757 790 12 receptors receptor NNS 10_1101-2020_03_27_012757 790 13 and and CC 10_1101-2020_03_27_012757 790 14 1113 1113 CD 10_1101-2020_03_27_012757 790 15 E e NN 10_1101-2020_03_27_012757 790 16 - - NN 10_1101-2020_03_27_012757 790 17 cadherin cadherin NN 10_1101-2020_03_27_012757 790 18 in in IN 10_1101-2020_03_27_012757 790 19 aggressive aggressive JJ 10_1101-2020_03_27_012757 790 20 subtypes subtype NNS 10_1101-2020_03_27_012757 790 21 of of IN 10_1101-2020_03_27_012757 790 22 endometrial endometrial JJ 10_1101-2020_03_27_012757 790 23 carcinomas carcinoma NNS 10_1101-2020_03_27_012757 790 24 . . . 10_1101-2020_03_27_012757 791 1 J. J. NNP 10_1101-2020_03_27_012757 791 2 Pathol Pathol NNP 10_1101-2020_03_27_012757 791 3 . . . 10_1101-2020_03_27_012757 792 1 220 220 CD 10_1101-2020_03_27_012757 792 2 , , , 10_1101-2020_03_27_012757 792 3 551–1114 551–1114 NNP 10_1101-2020_03_27_012757 792 4 561 561 CD 10_1101-2020_03_27_012757 792 5 ( ( -LRB- 10_1101-2020_03_27_012757 792 6 2010 2010 CD 10_1101-2020_03_27_012757 792 7 ) ) -RRB- 10_1101-2020_03_27_012757 792 8 . . . 10_1101-2020_03_27_012757 793 1 1115 1115 CD 10_1101-2020_03_27_012757 793 2 55 55 CD 10_1101-2020_03_27_012757 793 3 . . . 10_1101-2020_03_27_012757 794 1 Kozak Kozak NNP 10_1101-2020_03_27_012757 794 2 , , , 10_1101-2020_03_27_012757 794 3 J. J. NNP 10_1101-2020_03_27_012757 794 4 , , , 10_1101-2020_03_27_012757 794 5 Wdowiak Wdowiak NNP 10_1101-2020_03_27_012757 794 6 , , , 10_1101-2020_03_27_012757 794 7 P. P. NNP 10_1101-2020_03_27_012757 794 8 , , , 10_1101-2020_03_27_012757 794 9 Maciejewski Maciejewski NNP 10_1101-2020_03_27_012757 794 10 , , , 10_1101-2020_03_27_012757 794 11 R. R. NNP 10_1101-2020_03_27_012757 794 12 & & CC 10_1101-2020_03_27_012757 794 13 Torres Torres NNP 10_1101-2020_03_27_012757 794 14 , , , 10_1101-2020_03_27_012757 794 15 A. a. NN 10_1101-2020_03_27_012757 795 1 A a DT 10_1101-2020_03_27_012757 795 2 guide guide NN 10_1101-2020_03_27_012757 795 3 for for IN 10_1101-2020_03_27_012757 795 4 endometrial endometrial JJ 10_1101-2020_03_27_012757 795 5 1116 1116 CD 10_1101-2020_03_27_012757 795 6 cancer cancer NN 10_1101-2020_03_27_012757 795 7 cell cell NN 10_1101-2020_03_27_012757 795 8 lines line NNS 10_1101-2020_03_27_012757 795 9 functional functional JJ 10_1101-2020_03_27_012757 795 10 assays assays RB 10_1101-2020_03_27_012757 795 11 using use VBG 10_1101-2020_03_27_012757 795 12 the the DT 10_1101-2020_03_27_012757 795 13 measurements measurement NNS 10_1101-2020_03_27_012757 795 14 of of IN 10_1101-2020_03_27_012757 795 15 electronic electronic JJ 10_1101-2020_03_27_012757 795 16 1117 1117 CD 10_1101-2020_03_27_012757 795 17 impedance impedance NN 10_1101-2020_03_27_012757 795 18 . . . 10_1101-2020_03_27_012757 796 1 Cytotechnology cytotechnology NN 10_1101-2020_03_27_012757 796 2 70 70 CD 10_1101-2020_03_27_012757 796 3 , , , 10_1101-2020_03_27_012757 796 4 339–350 339–350 CD 10_1101-2020_03_27_012757 796 5 ( ( -LRB- 10_1101-2020_03_27_012757 796 6 2018 2018 CD 10_1101-2020_03_27_012757 796 7 ) ) -RRB- 10_1101-2020_03_27_012757 796 8 . . . 10_1101-2020_03_27_012757 797 1 1118 1118 CD 10_1101-2020_03_27_012757 797 2 56 56 CD 10_1101-2020_03_27_012757 797 3 . . . 10_1101-2020_03_27_012757 798 1 Korch Korch NNP 10_1101-2020_03_27_012757 798 2 , , , 10_1101-2020_03_27_012757 798 3 C. C. NNP 10_1101-2020_03_27_012757 798 4 et et NNP 10_1101-2020_03_27_012757 798 5 al al NNP 10_1101-2020_03_27_012757 798 6 . . . 10_1101-2020_03_27_012757 799 1 DNA dna NN 10_1101-2020_03_27_012757 799 2 profiling profile VBG 10_1101-2020_03_27_012757 799 3 analysis analysis NN 10_1101-2020_03_27_012757 799 4 of of IN 10_1101-2020_03_27_012757 799 5 endometrial endometrial JJ 10_1101-2020_03_27_012757 799 6 and and CC 10_1101-2020_03_27_012757 799 7 ovarian ovarian JJ 10_1101-2020_03_27_012757 799 8 cell cell NN 10_1101-2020_03_27_012757 799 9 lines line NNS 10_1101-2020_03_27_012757 799 10 reveals reveal VBZ 10_1101-2020_03_27_012757 799 11 1119 1119 CD 10_1101-2020_03_27_012757 799 12 misidentification misidentification NN 10_1101-2020_03_27_012757 799 13 , , , 10_1101-2020_03_27_012757 799 14 redundancy redundancy NN 10_1101-2020_03_27_012757 799 15 and and CC 10_1101-2020_03_27_012757 799 16 contamination contamination NN 10_1101-2020_03_27_012757 799 17 . . . 10_1101-2020_03_27_012757 800 1 Gynecol Gynecol NNP 10_1101-2020_03_27_012757 800 2 . . . 10_1101-2020_03_27_012757 801 1 Oncol Oncol NNP 10_1101-2020_03_27_012757 801 2 . . . 10_1101-2020_03_27_012757 802 1 127 127 CD 10_1101-2020_03_27_012757 802 2 , , , 10_1101-2020_03_27_012757 802 3 241–248 241–248 CD 10_1101-2020_03_27_012757 802 4 1120 1120 CD 10_1101-2020_03_27_012757 802 5 ( ( -LRB- 10_1101-2020_03_27_012757 802 6 2012 2012 CD 10_1101-2020_03_27_012757 802 7 ) ) -RRB- 10_1101-2020_03_27_012757 802 8 . . . 10_1101-2020_03_27_012757 803 1 1121 1121 CD 10_1101-2020_03_27_012757 803 2 57 57 CD 10_1101-2020_03_27_012757 803 3 . . . 10_1101-2020_03_27_012757 804 1 Wu Wu NNP 10_1101-2020_03_27_012757 804 2 , , , 10_1101-2020_03_27_012757 804 3 D. D. NNP 10_1101-2020_03_27_012757 804 4 et et NNP 10_1101-2020_03_27_012757 804 5 al al NNP 10_1101-2020_03_27_012757 804 6 . . . 10_1101-2020_03_27_012757 805 1 Gene gene NN 10_1101-2020_03_27_012757 805 2 - - HYPH 10_1101-2020_03_27_012757 805 3 expression expression NN 10_1101-2020_03_27_012757 805 4 data datum NNS 10_1101-2020_03_27_012757 805 5 integration integration NN 10_1101-2020_03_27_012757 805 6 to to IN 10_1101-2020_03_27_012757 805 7 squamous squamous JJ 10_1101-2020_03_27_012757 805 8 cell cell NN 10_1101-2020_03_27_012757 805 9 lung lung NN 10_1101-2020_03_27_012757 805 10 cancer cancer NN 10_1101-2020_03_27_012757 805 11 1122 1122 CD 10_1101-2020_03_27_012757 805 12 subtypes subtype NNS 10_1101-2020_03_27_012757 805 13 reveals reveal VBZ 10_1101-2020_03_27_012757 805 14 drug drug NN 10_1101-2020_03_27_012757 805 15 sensitivity sensitivity NN 10_1101-2020_03_27_012757 805 16 . . . 10_1101-2020_03_27_012757 806 1 Br br UH 10_1101-2020_03_27_012757 806 2 . . . 10_1101-2020_03_27_012757 807 1 J. J. NNP 10_1101-2020_03_27_012757 808 1 Cancer cancer NN 10_1101-2020_03_27_012757 808 2 109 109 CD 10_1101-2020_03_27_012757 808 3 , , , 10_1101-2020_03_27_012757 808 4 1599–1608 1599–1608 CD 10_1101-2020_03_27_012757 808 5 ( ( -LRB- 10_1101-2020_03_27_012757 808 6 2013 2013 CD 10_1101-2020_03_27_012757 808 7 ) ) -RRB- 10_1101-2020_03_27_012757 808 8 . . . 10_1101-2020_03_27_012757 809 1 1123 1123 CD 10_1101-2020_03_27_012757 809 2 58 58 CD 10_1101-2020_03_27_012757 809 3 . . . 10_1101-2020_03_27_012757 810 1 Walter Walter NNP 10_1101-2020_03_27_012757 810 2 , , , 10_1101-2020_03_27_012757 810 3 V. V. NNP 10_1101-2020_03_27_012757 810 4 et et NNP 10_1101-2020_03_27_012757 810 5 al al NNP 10_1101-2020_03_27_012757 810 6 . . . 10_1101-2020_03_27_012757 811 1 Molecular molecular JJ 10_1101-2020_03_27_012757 811 2 subtypes subtype NNS 10_1101-2020_03_27_012757 811 3 in in IN 10_1101-2020_03_27_012757 811 4 head head NN 10_1101-2020_03_27_012757 811 5 and and CC 10_1101-2020_03_27_012757 811 6 neck neck NN 10_1101-2020_03_27_012757 811 7 cancer cancer NN 10_1101-2020_03_27_012757 811 8 exhibit exhibit NN 10_1101-2020_03_27_012757 811 9 distinct distinct JJ 10_1101-2020_03_27_012757 811 10 1124 1124 CD 10_1101-2020_03_27_012757 811 11 patterns pattern NNS 10_1101-2020_03_27_012757 811 12 of of IN 10_1101-2020_03_27_012757 811 13 chromosomal chromosomal JJ 10_1101-2020_03_27_012757 811 14 gain gain NN 10_1101-2020_03_27_012757 811 15 and and CC 10_1101-2020_03_27_012757 811 16 loss loss NN 10_1101-2020_03_27_012757 811 17 of of IN 10_1101-2020_03_27_012757 811 18 canonical canonical JJ 10_1101-2020_03_27_012757 811 19 cancer cancer NN 10_1101-2020_03_27_012757 811 20 genes gene NNS 10_1101-2020_03_27_012757 811 21 . . . 10_1101-2020_03_27_012757 812 1 PLoS plos ADD 10_1101-2020_03_27_012757 812 2 One one CD 10_1101-2020_03_27_012757 812 3 8 8 CD 10_1101-2020_03_27_012757 812 4 , , , 10_1101-2020_03_27_012757 812 5 1125 1125 CD 10_1101-2020_03_27_012757 812 6 e56823 e56823 NNP 10_1101-2020_03_27_012757 812 7 ( ( -LRB- 10_1101-2020_03_27_012757 812 8 2013 2013 CD 10_1101-2020_03_27_012757 812 9 ) ) -RRB- 10_1101-2020_03_27_012757 812 10 . . . 10_1101-2020_03_27_012757 813 1 1126 1126 CD 10_1101-2020_03_27_012757 813 2 59 59 CD 10_1101-2020_03_27_012757 813 3 . . . 10_1101-2020_03_27_012757 814 1 Adeegbe adeegbe VB 10_1101-2020_03_27_012757 814 2 , , , 10_1101-2020_03_27_012757 814 3 D. D. NNP 10_1101-2020_03_27_012757 814 4 O. O. NNP 10_1101-2020_03_27_012757 814 5 et et NNP 10_1101-2020_03_27_012757 814 6 al al NNP 10_1101-2020_03_27_012757 814 7 . . . 10_1101-2020_03_27_012757 815 1 BET BET NNP 10_1101-2020_03_27_012757 815 2 Bromodomain bromodomain JJ 10_1101-2020_03_27_012757 815 3 Inhibition inhibition NN 10_1101-2020_03_27_012757 815 4 Cooperates cooperate NNS 10_1101-2020_03_27_012757 815 5 with with IN 10_1101-2020_03_27_012757 815 6 PD-1 PD-1 NNP 10_1101-2020_03_27_012757 815 7 Blockade Blockade NNP 10_1101-2020_03_27_012757 815 8 1127 1127 CD 10_1101-2020_03_27_012757 815 9 to to IN 10_1101-2020_03_27_012757 815 10 Facilitate Facilitate NNP 10_1101-2020_03_27_012757 815 11 Antitumor Antitumor NNP 10_1101-2020_03_27_012757 815 12 Response Response NNP 10_1101-2020_03_27_012757 815 13 in in IN 10_1101-2020_03_27_012757 815 14 Kras Kras NNP 10_1101-2020_03_27_012757 815 15 - - HYPH 10_1101-2020_03_27_012757 815 16 Mutant Mutant NNP 10_1101-2020_03_27_012757 815 17 Non non JJ 10_1101-2020_03_27_012757 815 18 - - JJ 10_1101-2020_03_27_012757 815 19 Small small JJ 10_1101-2020_03_27_012757 815 20 Cell Cell NNP 10_1101-2020_03_27_012757 815 21 Lung Lung NNP 10_1101-2020_03_27_012757 815 22 Cancer Cancer NNP 10_1101-2020_03_27_012757 815 23 . . . 10_1101-2020_03_27_012757 816 1 1128 1128 CD 10_1101-2020_03_27_012757 816 2 Cancer Cancer NNP 10_1101-2020_03_27_012757 816 3 Immunol Immunol NNP 10_1101-2020_03_27_012757 816 4 Res Res NNP 10_1101-2020_03_27_012757 816 5 6 6 CD 10_1101-2020_03_27_012757 816 6 , , , 10_1101-2020_03_27_012757 816 7 1234–1245 1234–1245 CD 10_1101-2020_03_27_012757 816 8 ( ( -LRB- 10_1101-2020_03_27_012757 816 9 2018 2018 CD 10_1101-2020_03_27_012757 816 10 ) ) -RRB- 10_1101-2020_03_27_012757 816 11 . . . 10_1101-2020_03_27_012757 817 1 1129 1129 CD 10_1101-2020_03_27_012757 817 2 60 60 CD 10_1101-2020_03_27_012757 817 3 . . . 10_1101-2020_03_27_012757 818 1 Blaisdell Blaisdell NNP 10_1101-2020_03_27_012757 818 2 , , , 10_1101-2020_03_27_012757 818 3 A. A. NNP 10_1101-2020_03_27_012757 818 4 et et FW 10_1101-2020_03_27_012757 818 5 al al NNP 10_1101-2020_03_27_012757 818 6 . . . 10_1101-2020_03_27_012757 819 1 Neutrophils neutrophil NNS 10_1101-2020_03_27_012757 819 2 oppose oppose VBP 10_1101-2020_03_27_012757 819 3 uterine uterine JJ 10_1101-2020_03_27_012757 819 4 epithelial epithelial JJ 10_1101-2020_03_27_012757 819 5 carcinogenesis carcinogenesis NN 10_1101-2020_03_27_012757 819 6 via via IN 10_1101-2020_03_27_012757 819 7 1130 1130 CD 10_1101-2020_03_27_012757 819 8 debridement debridement NN 10_1101-2020_03_27_012757 819 9 of of IN 10_1101-2020_03_27_012757 819 10 hypoxic hypoxic JJ 10_1101-2020_03_27_012757 819 11 tumor tumor NN 10_1101-2020_03_27_012757 819 12 cells cell NNS 10_1101-2020_03_27_012757 819 13 . . . 10_1101-2020_03_27_012757 820 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 820 2 Cell Cell NNP 10_1101-2020_03_27_012757 820 3 28 28 CD 10_1101-2020_03_27_012757 820 4 , , , 10_1101-2020_03_27_012757 820 5 785–799 785–799 CD 10_1101-2020_03_27_012757 820 6 ( ( -LRB- 10_1101-2020_03_27_012757 820 7 2015 2015 CD 10_1101-2020_03_27_012757 820 8 ) ) -RRB- 10_1101-2020_03_27_012757 820 9 . . . 10_1101-2020_03_27_012757 821 1 1131 1131 CD 10_1101-2020_03_27_012757 821 2 61 61 CD 10_1101-2020_03_27_012757 821 3 . . . 10_1101-2020_03_27_012757 822 1 Fitamant Fitamant NNP 10_1101-2020_03_27_012757 822 2 , , , 10_1101-2020_03_27_012757 822 3 J. J. NNP 10_1101-2020_03_27_012757 822 4 et et NNP 10_1101-2020_03_27_012757 822 5 al al NNP 10_1101-2020_03_27_012757 822 6 . . . 10_1101-2020_03_27_012757 823 1 YAP yap NN 10_1101-2020_03_27_012757 823 2 inhibition inhibition NN 10_1101-2020_03_27_012757 823 3 restores restore VBZ 10_1101-2020_03_27_012757 823 4 hepatocyte hepatocyte VBD 10_1101-2020_03_27_012757 823 5 differentiation differentiation NN 10_1101-2020_03_27_012757 823 6 in in IN 10_1101-2020_03_27_012757 823 7 advanced advanced JJ 10_1101-2020_03_27_012757 823 8 1132 1132 CD 10_1101-2020_03_27_012757 823 9 HCC HCC NNP 10_1101-2020_03_27_012757 823 10 , , , 10_1101-2020_03_27_012757 823 11 leading lead VBG 10_1101-2020_03_27_012757 823 12 to to IN 10_1101-2020_03_27_012757 823 13 tumor tumor NN 10_1101-2020_03_27_012757 823 14 regression regression NN 10_1101-2020_03_27_012757 823 15 . . . 10_1101-2020_03_27_012757 824 1 Cell Cell NNP 10_1101-2020_03_27_012757 824 2 Rep. Rep. NNP 10_1101-2020_03_27_012757 824 3 10 10 CD 10_1101-2020_03_27_012757 824 4 , , , 10_1101-2020_03_27_012757 824 5 1692–1707 1692–1707 CD 10_1101-2020_03_27_012757 824 6 ( ( -LRB- 10_1101-2020_03_27_012757 824 7 2015 2015 CD 10_1101-2020_03_27_012757 824 8 ) ) -RRB- 10_1101-2020_03_27_012757 824 9 . . . 10_1101-2020_03_27_012757 825 1 1133 1133 CD 10_1101-2020_03_27_012757 825 2 62 62 CD 10_1101-2020_03_27_012757 825 3 . . . 10_1101-2020_03_27_012757 826 1 Jia Jia NNP 10_1101-2020_03_27_012757 826 2 , , , 10_1101-2020_03_27_012757 826 3 D. D. NNP 10_1101-2020_03_27_012757 826 4 et et NNP 10_1101-2020_03_27_012757 826 5 al al NNP 10_1101-2020_03_27_012757 826 6 . . . 10_1101-2020_03_27_012757 827 1 Crebbp Crebbp NNP 10_1101-2020_03_27_012757 827 2 loss loss NN 10_1101-2020_03_27_012757 827 3 drives drive VBZ 10_1101-2020_03_27_012757 827 4 small small JJ 10_1101-2020_03_27_012757 827 5 cell cell NN 10_1101-2020_03_27_012757 827 6 lung lung NN 10_1101-2020_03_27_012757 827 7 cancer cancer NN 10_1101-2020_03_27_012757 827 8 and and CC 10_1101-2020_03_27_012757 827 9 increases increase VBZ 10_1101-2020_03_27_012757 827 10 sensitivity sensitivity NN 10_1101-2020_03_27_012757 827 11 to to IN 10_1101-2020_03_27_012757 827 12 1134 1134 CD 10_1101-2020_03_27_012757 827 13 HDAC HDAC NNP 10_1101-2020_03_27_012757 827 14 inhibition inhibition NN 10_1101-2020_03_27_012757 827 15 . . . 10_1101-2020_03_27_012757 828 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 828 2 Discov Discov NNP 10_1101-2020_03_27_012757 828 3 . . . 10_1101-2020_03_27_012757 829 1 8 8 CD 10_1101-2020_03_27_012757 829 2 , , , 10_1101-2020_03_27_012757 829 3 1422–1437 1422–1437 CD 10_1101-2020_03_27_012757 829 4 ( ( -LRB- 10_1101-2020_03_27_012757 829 5 2018 2018 CD 10_1101-2020_03_27_012757 829 6 ) ) -RRB- 10_1101-2020_03_27_012757 829 7 . . . 10_1101-2020_03_27_012757 830 1 1135 1135 CD 10_1101-2020_03_27_012757 830 2 63 63 CD 10_1101-2020_03_27_012757 830 3 . . . 10_1101-2020_03_27_012757 831 1 Kress Kress NNP 10_1101-2020_03_27_012757 831 2 , , , 10_1101-2020_03_27_012757 831 3 T. T. NNP 10_1101-2020_03_27_012757 831 4 R. R. NNP 10_1101-2020_03_27_012757 831 5 et et NNP 10_1101-2020_03_27_012757 831 6 al al NNP 10_1101-2020_03_27_012757 831 7 . . . 10_1101-2020_03_27_012757 832 1 Identification identification NN 10_1101-2020_03_27_012757 832 2 of of IN 10_1101-2020_03_27_012757 832 3 MYC MYC NNP 10_1101-2020_03_27_012757 832 4 - - HYPH 10_1101-2020_03_27_012757 832 5 Dependent Dependent NNP 10_1101-2020_03_27_012757 832 6 Transcriptional Transcriptional NNP 10_1101-2020_03_27_012757 832 7 Programs Programs NNPS 10_1101-2020_03_27_012757 832 8 in in IN 10_1101-2020_03_27_012757 832 9 1136 1136 CD 10_1101-2020_03_27_012757 832 10 Oncogene Oncogene NNP 10_1101-2020_03_27_012757 832 11 - - HYPH 10_1101-2020_03_27_012757 832 12 Addicted addict VBN 10_1101-2020_03_27_012757 832 13 Liver Liver NNP 10_1101-2020_03_27_012757 832 14 Tumors Tumors NNPS 10_1101-2020_03_27_012757 832 15 . . . 10_1101-2020_03_27_012757 833 1 Cancer cancer NN 10_1101-2020_03_27_012757 833 2 Res Res NNP 10_1101-2020_03_27_012757 833 3 . . . 10_1101-2020_03_27_012757 834 1 76 76 CD 10_1101-2020_03_27_012757 834 2 , , , 10_1101-2020_03_27_012757 834 3 3463–3472 3463–3472 CD 10_1101-2020_03_27_012757 834 4 ( ( -LRB- 10_1101-2020_03_27_012757 834 5 2016 2016 CD 10_1101-2020_03_27_012757 834 6 ) ) -RRB- 10_1101-2020_03_27_012757 834 7 . . . 10_1101-2020_03_27_012757 835 1 1137 1137 CD 10_1101-2020_03_27_012757 835 2 64 64 CD 10_1101-2020_03_27_012757 835 3 . . . 10_1101-2020_03_27_012757 836 1 Li Li NNP 10_1101-2020_03_27_012757 836 2 , , , 10_1101-2020_03_27_012757 836 3 L. L. NNP 10_1101-2020_03_27_012757 836 4 et et NNP 10_1101-2020_03_27_012757 836 5 al al NNP 10_1101-2020_03_27_012757 836 6 . . . 10_1101-2020_03_27_012757 837 1 GKAP GKAP NNP 10_1101-2020_03_27_012757 837 2 acts act VBZ 10_1101-2020_03_27_012757 837 3 as as IN 10_1101-2020_03_27_012757 837 4 a a DT 10_1101-2020_03_27_012757 837 5 genetic genetic JJ 10_1101-2020_03_27_012757 837 6 modulator modulator NN 10_1101-2020_03_27_012757 837 7 of of IN 10_1101-2020_03_27_012757 837 8 NMDAR NMDAR NNS 10_1101-2020_03_27_012757 837 9 signaling signal VBG 10_1101-2020_03_27_012757 837 10 to to TO 10_1101-2020_03_27_012757 837 11 govern govern VB 10_1101-2020_03_27_012757 837 12 1138 1138 CD 10_1101-2020_03_27_012757 837 13 invasive invasive JJ 10_1101-2020_03_27_012757 837 14 tumor tumor NN 10_1101-2020_03_27_012757 837 15 growth growth NN 10_1101-2020_03_27_012757 837 16 . . . 10_1101-2020_03_27_012757 838 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 838 2 Cell Cell NNP 10_1101-2020_03_27_012757 838 3 33 33 CD 10_1101-2020_03_27_012757 838 4 , , , 10_1101-2020_03_27_012757 838 5 736–751.e5 736–751.e5 NNS 10_1101-2020_03_27_012757 838 6 ( ( -LRB- 10_1101-2020_03_27_012757 838 7 2018 2018 CD 10_1101-2020_03_27_012757 838 8 ) ) -RRB- 10_1101-2020_03_27_012757 838 9 . . . 10_1101-2020_03_27_012757 839 1 1139 1139 CD 10_1101-2020_03_27_012757 839 2 65 65 CD 10_1101-2020_03_27_012757 839 3 . . . 10_1101-2020_03_27_012757 840 1 Mollaoglu Mollaoglu NNP 10_1101-2020_03_27_012757 840 2 , , , 10_1101-2020_03_27_012757 840 3 G. G. NNP 10_1101-2020_03_27_012757 840 4 et et NNP 10_1101-2020_03_27_012757 840 5 al al NNP 10_1101-2020_03_27_012757 840 6 . . . 10_1101-2020_03_27_012757 841 1 The the DT 10_1101-2020_03_27_012757 841 2 Lineage Lineage NNP 10_1101-2020_03_27_012757 841 3 - - HYPH 10_1101-2020_03_27_012757 841 4 Defining Defining NNP 10_1101-2020_03_27_012757 841 5 Transcription Transcription NNP 10_1101-2020_03_27_012757 841 6 Factors Factors NNP 10_1101-2020_03_27_012757 841 7 SOX2 SOX2 NNPS 10_1101-2020_03_27_012757 841 8 and and CC 10_1101-2020_03_27_012757 841 9 NKX2 NKX2 NNP 10_1101-2020_03_27_012757 841 10 - - HYPH 10_1101-2020_03_27_012757 841 11 1 1 CD 10_1101-2020_03_27_012757 841 12 1140 1140 CD 10_1101-2020_03_27_012757 841 13 Determine Determine NNP 10_1101-2020_03_27_012757 841 14 Lung Lung NNP 10_1101-2020_03_27_012757 841 15 Cancer Cancer NNP 10_1101-2020_03_27_012757 841 16 Cell Cell NNP 10_1101-2020_03_27_012757 841 17 Fate Fate NNP 10_1101-2020_03_27_012757 841 18 and and CC 10_1101-2020_03_27_012757 841 19 Shape Shape NNP 10_1101-2020_03_27_012757 841 20 the the DT 10_1101-2020_03_27_012757 841 21 Tumor Tumor NNP 10_1101-2020_03_27_012757 841 22 Immune Immune NNP 10_1101-2020_03_27_012757 841 23 1141 1141 CD 10_1101-2020_03_27_012757 841 24 Microenvironment Microenvironment NNP 10_1101-2020_03_27_012757 841 25 . . . 10_1101-2020_03_27_012757 842 1 Immunity immunity NN 10_1101-2020_03_27_012757 842 2 49 49 CD 10_1101-2020_03_27_012757 842 3 , , , 10_1101-2020_03_27_012757 842 4 764–779.e9 764–779.e9 CD 10_1101-2020_03_27_012757 842 5 ( ( -LRB- 10_1101-2020_03_27_012757 842 6 2018 2018 CD 10_1101-2020_03_27_012757 842 7 ) ) -RRB- 10_1101-2020_03_27_012757 842 8 . . . 10_1101-2020_03_27_012757 843 1 1142 1142 CD 10_1101-2020_03_27_012757 843 2 .CC .CC : 10_1101-2020_03_27_012757 843 3 - - : 10_1101-2020_03_27_012757 843 4 BY BY NNP 10_1101-2020_03_27_012757 843 5 - - HYPH 10_1101-2020_03_27_012757 843 6 NC NC NNP 10_1101-2020_03_27_012757 843 7 - - HYPH 10_1101-2020_03_27_012757 843 8 ND ND NNP 10_1101-2020_03_27_012757 843 9 4.0 4.0 CD 10_1101-2020_03_27_012757 843 10 International International NNP 10_1101-2020_03_27_012757 843 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 843 12 under under IN 10_1101-2020_03_27_012757 843 13 a a DT 10_1101-2020_03_27_012757 843 14 ( ( -LRB- 10_1101-2020_03_27_012757 843 15 which which WDT 10_1101-2020_03_27_012757 843 16 was be VBD 10_1101-2020_03_27_012757 843 17 not not RB 10_1101-2020_03_27_012757 843 18 certified certify VBN 10_1101-2020_03_27_012757 843 19 by by IN 10_1101-2020_03_27_012757 843 20 peer peer NN 10_1101-2020_03_27_012757 843 21 review review NN 10_1101-2020_03_27_012757 843 22 ) ) -RRB- 10_1101-2020_03_27_012757 843 23 is be VBZ 10_1101-2020_03_27_012757 843 24 the the DT 10_1101-2020_03_27_012757 843 25 author author NN 10_1101-2020_03_27_012757 843 26 / / SYM 10_1101-2020_03_27_012757 843 27 funder funder NN 10_1101-2020_03_27_012757 843 28 , , , 10_1101-2020_03_27_012757 843 29 who who WP 10_1101-2020_03_27_012757 843 30 has have VBZ 10_1101-2020_03_27_012757 843 31 granted grant VBN 10_1101-2020_03_27_012757 843 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 843 33 a a DT 10_1101-2020_03_27_012757 843 34 license license NN 10_1101-2020_03_27_012757 843 35 to to TO 10_1101-2020_03_27_012757 843 36 display display VB 10_1101-2020_03_27_012757 843 37 the the DT 10_1101-2020_03_27_012757 843 38 preprint preprint NN 10_1101-2020_03_27_012757 843 39 in in IN 10_1101-2020_03_27_012757 843 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 843 41 . . . 10_1101-2020_03_27_012757 844 1 It -PRON- PRP 10_1101-2020_03_27_012757 844 2 is be VBZ 10_1101-2020_03_27_012757 844 3 made make VBN 10_1101-2020_03_27_012757 844 4 The the DT 10_1101-2020_03_27_012757 844 5 copyright copyright NN 10_1101-2020_03_27_012757 844 6 holder holder NN 10_1101-2020_03_27_012757 844 7 for for IN 10_1101-2020_03_27_012757 844 8 this this DT 10_1101-2020_03_27_012757 844 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 844 10 version version NN 10_1101-2020_03_27_012757 844 11 posted post VBD 10_1101-2020_03_27_012757 844 12 January January NNP 10_1101-2020_03_27_012757 844 13 9 9 CD 10_1101-2020_03_27_012757 844 14 , , , 10_1101-2020_03_27_012757 844 15 2021 2021 CD 10_1101-2020_03_27_012757 844 16 . . . 10_1101-2020_03_27_012757 844 17 ; ; : 10_1101-2020_03_27_012757 844 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 844 19 : : : 10_1101-2020_03_27_012757 844 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 844 21 preprint preprint NN 10_1101-2020_03_27_012757 844 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 NNP 10_1101-2020_03_27_012757 844 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 844 24 41 41 CD 10_1101-2020_03_27_012757 844 25 66 66 CD 10_1101-2020_03_27_012757 844 26 . . . 10_1101-2020_03_27_012757 845 1 Pan Pan NNP 10_1101-2020_03_27_012757 845 2 , , , 10_1101-2020_03_27_012757 845 3 Y. Y. NNP 10_1101-2020_03_27_012757 845 4 et et NNP 10_1101-2020_03_27_012757 845 5 al al NNP 10_1101-2020_03_27_012757 845 6 . . . 10_1101-2020_03_27_012757 846 1 Whole whole JJ 10_1101-2020_03_27_012757 846 2 tumor tumor NN 10_1101-2020_03_27_012757 846 3 RNA RNA NNP 10_1101-2020_03_27_012757 846 4 - - HYPH 10_1101-2020_03_27_012757 846 5 sequencing sequencing NN 10_1101-2020_03_27_012757 846 6 and and CC 10_1101-2020_03_27_012757 846 7 deconvolution deconvolution NN 10_1101-2020_03_27_012757 846 8 reveal reveal VB 10_1101-2020_03_27_012757 846 9 a a DT 10_1101-2020_03_27_012757 846 10 clinically-1143 clinically-1143 JJ 10_1101-2020_03_27_012757 846 11 prognostic prognostic JJ 10_1101-2020_03_27_012757 846 12 PTEN PTEN NNP 10_1101-2020_03_27_012757 846 13 / / SYM 10_1101-2020_03_27_012757 846 14 PI3K PI3K NNP 10_1101-2020_03_27_012757 846 15 - - HYPH 10_1101-2020_03_27_012757 846 16 regulated regulated JJ 10_1101-2020_03_27_012757 846 17 glioma glioma NNP 10_1101-2020_03_27_012757 846 18 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 846 19 signature signature NN 10_1101-2020_03_27_012757 846 20 . . . 10_1101-2020_03_27_012757 847 1 Oncotarget Oncotarget NNP 10_1101-2020_03_27_012757 847 2 8 8 CD 10_1101-2020_03_27_012757 847 3 , , , 10_1101-2020_03_27_012757 847 4 1144 1144 CD 10_1101-2020_03_27_012757 847 5 52474–52487 52474–52487 CD 10_1101-2020_03_27_012757 847 6 ( ( -LRB- 10_1101-2020_03_27_012757 847 7 2017 2017 CD 10_1101-2020_03_27_012757 847 8 ) ) -RRB- 10_1101-2020_03_27_012757 847 9 . . . 10_1101-2020_03_27_012757 848 1 1145 1145 CD 10_1101-2020_03_27_012757 848 2 67 67 CD 10_1101-2020_03_27_012757 848 3 . . . 10_1101-2020_03_27_012757 849 1 Lissanu Lissanu NNP 10_1101-2020_03_27_012757 849 2 Deribe Deribe NNP 10_1101-2020_03_27_012757 849 3 , , , 10_1101-2020_03_27_012757 849 4 Y. Y. NNP 10_1101-2020_03_27_012757 849 5 et et NNP 10_1101-2020_03_27_012757 849 6 al al NNP 10_1101-2020_03_27_012757 849 7 . . . 10_1101-2020_03_27_012757 850 1 Mutations mutation NNS 10_1101-2020_03_27_012757 850 2 in in IN 10_1101-2020_03_27_012757 850 3 the the DT 10_1101-2020_03_27_012757 850 4 SWI SWI NNP 10_1101-2020_03_27_012757 850 5 / / SYM 10_1101-2020_03_27_012757 850 6 SNF SNF NNP 10_1101-2020_03_27_012757 850 7 complex complex JJ 10_1101-2020_03_27_012757 850 8 induce induce VBP 10_1101-2020_03_27_012757 850 9 a a DT 10_1101-2020_03_27_012757 850 10 targetable targetable NN 10_1101-2020_03_27_012757 850 11 1146 1146 CD 10_1101-2020_03_27_012757 850 12 dependence dependence NN 10_1101-2020_03_27_012757 850 13 on on IN 10_1101-2020_03_27_012757 850 14 oxidative oxidative JJ 10_1101-2020_03_27_012757 850 15 phosphorylation phosphorylation NN 10_1101-2020_03_27_012757 850 16 in in IN 10_1101-2020_03_27_012757 850 17 lung lung NN 10_1101-2020_03_27_012757 850 18 cancer cancer NN 10_1101-2020_03_27_012757 850 19 . . . 10_1101-2020_03_27_012757 851 1 Nat Nat NNP 10_1101-2020_03_27_012757 851 2 . . . 10_1101-2020_03_27_012757 852 1 Med Med NNP 10_1101-2020_03_27_012757 852 2 . . . 10_1101-2020_03_27_012757 853 1 24 24 CD 10_1101-2020_03_27_012757 853 2 , , , 10_1101-2020_03_27_012757 853 3 1047–1057 1047–1057 CD 10_1101-2020_03_27_012757 853 4 1147 1147 CD 10_1101-2020_03_27_012757 853 5 ( ( -LRB- 10_1101-2020_03_27_012757 853 6 2018 2018 CD 10_1101-2020_03_27_012757 853 7 ) ) -RRB- 10_1101-2020_03_27_012757 853 8 . . . 10_1101-2020_03_27_012757 854 1 1148 1148 CD 10_1101-2020_03_27_012757 854 2 68 68 CD 10_1101-2020_03_27_012757 854 3 . . . 10_1101-2020_03_27_012757 855 1 Xu Xu NNP 10_1101-2020_03_27_012757 855 2 , , , 10_1101-2020_03_27_012757 855 3 C. C. NNP 10_1101-2020_03_27_012757 855 4 et et NNP 10_1101-2020_03_27_012757 855 5 al al NNP 10_1101-2020_03_27_012757 855 6 . . . 10_1101-2020_03_27_012757 856 1 Loss loss NN 10_1101-2020_03_27_012757 856 2 of of IN 10_1101-2020_03_27_012757 856 3 Lkb1 Lkb1 NNP 10_1101-2020_03_27_012757 856 4 and and CC 10_1101-2020_03_27_012757 856 5 Pten Pten NNP 10_1101-2020_03_27_012757 856 6 leads lead VBZ 10_1101-2020_03_27_012757 856 7 to to IN 10_1101-2020_03_27_012757 856 8 lung lung VB 10_1101-2020_03_27_012757 856 9 squamous squamous JJ 10_1101-2020_03_27_012757 856 10 cell cell NN 10_1101-2020_03_27_012757 856 11 carcinoma carcinoma NN 10_1101-2020_03_27_012757 856 12 with with IN 10_1101-2020_03_27_012757 856 13 1149 1149 CD 10_1101-2020_03_27_012757 856 14 elevated elevated JJ 10_1101-2020_03_27_012757 856 15 PD PD NNP 10_1101-2020_03_27_012757 856 16 - - HYPH 10_1101-2020_03_27_012757 856 17 L1 L1 NNP 10_1101-2020_03_27_012757 856 18 expression expression NN 10_1101-2020_03_27_012757 856 19 . . . 10_1101-2020_03_27_012757 857 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 857 2 Cell Cell NNP 10_1101-2020_03_27_012757 857 3 25 25 CD 10_1101-2020_03_27_012757 857 4 , , , 10_1101-2020_03_27_012757 857 5 590–604 590–604 CD 10_1101-2020_03_27_012757 857 6 ( ( -LRB- 10_1101-2020_03_27_012757 857 7 2014 2014 CD 10_1101-2020_03_27_012757 857 8 ) ) -RRB- 10_1101-2020_03_27_012757 857 9 . . . 10_1101-2020_03_27_012757 858 1 1150 1150 CD 10_1101-2020_03_27_012757 858 2 69 69 CD 10_1101-2020_03_27_012757 858 3 . . . 10_1101-2020_03_27_012757 859 1 NCI NCI NNP 10_1101-2020_03_27_012757 859 2 - - HYPH 10_1101-2020_03_27_012757 859 3 Frederick Frederick NNP 10_1101-2020_03_27_012757 859 4 , , , 10_1101-2020_03_27_012757 859 5 Frederick Frederick NNP 10_1101-2020_03_27_012757 859 6 , , , 10_1101-2020_03_27_012757 859 7 MD MD NNP 10_1101-2020_03_27_012757 859 8 . . . 10_1101-2020_03_27_012757 860 1 National National NNP 10_1101-2020_03_27_012757 860 2 Laboratory Laboratory NNP 10_1101-2020_03_27_012757 860 3 for for IN 10_1101-2020_03_27_012757 860 4 Cancer Cancer NNP 10_1101-2020_03_27_012757 860 5 Research Research NNP 10_1101-2020_03_27_012757 860 6 . . . 10_1101-2020_03_27_012757 861 1 The the DT 10_1101-2020_03_27_012757 861 2 NCI NCI NNP 10_1101-2020_03_27_012757 861 3 1151 1151 CD 10_1101-2020_03_27_012757 861 4 Patient Patient NNP 10_1101-2020_03_27_012757 861 5 - - HYPH 10_1101-2020_03_27_012757 861 6 Derived derive VBN 10_1101-2020_03_27_012757 861 7 Models Models NNP 10_1101-2020_03_27_012757 861 8 Repository Repository NNP 10_1101-2020_03_27_012757 861 9 ( ( -LRB- 10_1101-2020_03_27_012757 861 10 PDMR PDMR NNP 10_1101-2020_03_27_012757 861 11 ) ) -RRB- 10_1101-2020_03_27_012757 861 12 . . . 10_1101-2020_03_27_012757 862 1 ( ( -LRB- 10_1101-2020_03_27_012757 862 2 2019 2019 CD 10_1101-2020_03_27_012757 862 3 ) ) -RRB- 10_1101-2020_03_27_012757 862 4 . . . 10_1101-2020_03_27_012757 863 1 at at IN 10_1101-2020_03_27_012757 863 2 < < XX 10_1101-2020_03_27_012757 863 3 https://pdmr.cancer.gov/ https://pdmr.cancer.gov/ NNP 10_1101-2020_03_27_012757 863 4 > > XX 10_1101-2020_03_27_012757 863 5 1152 1152 CD 10_1101-2020_03_27_012757 863 6 70 70 CD 10_1101-2020_03_27_012757 863 7 . . . 10_1101-2020_03_27_012757 864 1 Broutier Broutier NNP 10_1101-2020_03_27_012757 864 2 , , , 10_1101-2020_03_27_012757 864 3 L. L. NNP 10_1101-2020_03_27_012757 864 4 et et NNP 10_1101-2020_03_27_012757 864 5 al al NNP 10_1101-2020_03_27_012757 864 6 . . . 10_1101-2020_03_27_012757 865 1 Human human JJ 10_1101-2020_03_27_012757 865 2 primary primary JJ 10_1101-2020_03_27_012757 865 3 liver liver NN 10_1101-2020_03_27_012757 865 4 cancer cancer NN 10_1101-2020_03_27_012757 865 5 - - HYPH 10_1101-2020_03_27_012757 865 6 derived derive VBN 10_1101-2020_03_27_012757 865 7 organoid organoid JJ 10_1101-2020_03_27_012757 865 8 cultures culture NNS 10_1101-2020_03_27_012757 865 9 for for IN 10_1101-2020_03_27_012757 865 10 disease disease NN 10_1101-2020_03_27_012757 865 11 1153 1153 CD 10_1101-2020_03_27_012757 865 12 modeling modeling NN 10_1101-2020_03_27_012757 865 13 and and CC 10_1101-2020_03_27_012757 865 14 drug drug NN 10_1101-2020_03_27_012757 865 15 screening screening NN 10_1101-2020_03_27_012757 865 16 . . . 10_1101-2020_03_27_012757 866 1 Nat Nat NNP 10_1101-2020_03_27_012757 866 2 . . . 10_1101-2020_03_27_012757 867 1 Med Med NNP 10_1101-2020_03_27_012757 867 2 . . . 10_1101-2020_03_27_012757 868 1 23 23 CD 10_1101-2020_03_27_012757 868 2 , , , 10_1101-2020_03_27_012757 868 3 1424–1435 1424–1435 CD 10_1101-2020_03_27_012757 868 4 ( ( -LRB- 10_1101-2020_03_27_012757 868 5 2017 2017 CD 10_1101-2020_03_27_012757 868 6 ) ) -RRB- 10_1101-2020_03_27_012757 868 7 . . . 10_1101-2020_03_27_012757 869 1 1154 1154 CD 10_1101-2020_03_27_012757 869 2 71 71 CD 10_1101-2020_03_27_012757 869 3 . . . 10_1101-2020_03_27_012757 870 1 Lee Lee NNP 10_1101-2020_03_27_012757 870 2 , , , 10_1101-2020_03_27_012757 870 3 S. S. NNP 10_1101-2020_03_27_012757 870 4 H. H. NNP 10_1101-2020_03_27_012757 870 5 et et NNP 10_1101-2020_03_27_012757 870 6 al al NNP 10_1101-2020_03_27_012757 870 7 . . . 10_1101-2020_03_27_012757 871 1 Tumor Tumor NNP 10_1101-2020_03_27_012757 871 2 Evolution Evolution NNP 10_1101-2020_03_27_012757 871 3 and and CC 10_1101-2020_03_27_012757 871 4 Drug Drug NNP 10_1101-2020_03_27_012757 871 5 Response Response NNP 10_1101-2020_03_27_012757 871 6 in in IN 10_1101-2020_03_27_012757 871 7 Patient Patient NNP 10_1101-2020_03_27_012757 871 8 - - HYPH 10_1101-2020_03_27_012757 871 9 Derived derive VBN 10_1101-2020_03_27_012757 871 10 Organoid Organoid NNP 10_1101-2020_03_27_012757 871 11 1155 1155 CD 10_1101-2020_03_27_012757 871 12 Models Models NNPS 10_1101-2020_03_27_012757 871 13 of of IN 10_1101-2020_03_27_012757 871 14 Bladder Bladder NNP 10_1101-2020_03_27_012757 871 15 Cancer Cancer NNP 10_1101-2020_03_27_012757 871 16 . . . 10_1101-2020_03_27_012757 872 1 Cell cell NN 10_1101-2020_03_27_012757 872 2 173 173 CD 10_1101-2020_03_27_012757 872 3 , , , 10_1101-2020_03_27_012757 872 4 515–528.e17 515–528.e17 CD 10_1101-2020_03_27_012757 872 5 ( ( -LRB- 10_1101-2020_03_27_012757 872 6 2018 2018 CD 10_1101-2020_03_27_012757 872 7 ) ) -RRB- 10_1101-2020_03_27_012757 872 8 . . . 10_1101-2020_03_27_012757 873 1 1156 1156 CD 10_1101-2020_03_27_012757 873 2 72 72 CD 10_1101-2020_03_27_012757 873 3 . . . 10_1101-2020_03_27_012757 874 1 Ogawa Ogawa NNP 10_1101-2020_03_27_012757 874 2 , , , 10_1101-2020_03_27_012757 874 3 J. J. NNP 10_1101-2020_03_27_012757 874 4 , , , 10_1101-2020_03_27_012757 874 5 Pao Pao NNP 10_1101-2020_03_27_012757 874 6 , , , 10_1101-2020_03_27_012757 874 7 G. G. NNP 10_1101-2020_03_27_012757 874 8 M. M. NNP 10_1101-2020_03_27_012757 874 9 , , , 10_1101-2020_03_27_012757 874 10 Shokhirev Shokhirev NNP 10_1101-2020_03_27_012757 874 11 , , , 10_1101-2020_03_27_012757 874 12 M. M. NNP 10_1101-2020_03_27_012757 874 13 N. N. NNP 10_1101-2020_03_27_012757 874 14 & & CC 10_1101-2020_03_27_012757 874 15 Verma Verma NNP 10_1101-2020_03_27_012757 874 16 , , , 10_1101-2020_03_27_012757 874 17 I. I. NNP 10_1101-2020_03_27_012757 874 18 M. M. NNP 10_1101-2020_03_27_012757 874 19 Glioblastoma Glioblastoma NNP 10_1101-2020_03_27_012757 874 20 model model NN 10_1101-2020_03_27_012757 874 21 using use VBG 10_1101-2020_03_27_012757 874 22 1157 1157 CD 10_1101-2020_03_27_012757 874 23 human human JJ 10_1101-2020_03_27_012757 874 24 cerebral cerebral JJ 10_1101-2020_03_27_012757 874 25 organoids organoid NNS 10_1101-2020_03_27_012757 874 26 . . . 10_1101-2020_03_27_012757 875 1 Cell Cell NNP 10_1101-2020_03_27_012757 875 2 Rep. Rep. NNP 10_1101-2020_03_27_012757 875 3 23 23 CD 10_1101-2020_03_27_012757 875 4 , , , 10_1101-2020_03_27_012757 875 5 1220–1229 1220–1229 CD 10_1101-2020_03_27_012757 875 6 ( ( -LRB- 10_1101-2020_03_27_012757 875 7 2018 2018 CD 10_1101-2020_03_27_012757 875 8 ) ) -RRB- 10_1101-2020_03_27_012757 875 9 . . . 10_1101-2020_03_27_012757 876 1 1158 1158 CD 10_1101-2020_03_27_012757 876 2 73 73 CD 10_1101-2020_03_27_012757 876 3 . . . 10_1101-2020_03_27_012757 877 1 Ben Ben NNP 10_1101-2020_03_27_012757 877 2 - - HYPH 10_1101-2020_03_27_012757 877 3 David David NNP 10_1101-2020_03_27_012757 877 4 , , , 10_1101-2020_03_27_012757 877 5 U. U. NNP 10_1101-2020_03_27_012757 877 6 et et NNP 10_1101-2020_03_27_012757 877 7 al al NNP 10_1101-2020_03_27_012757 877 8 . . . 10_1101-2020_03_27_012757 878 1 Patient patient NN 10_1101-2020_03_27_012757 878 2 - - HYPH 10_1101-2020_03_27_012757 878 3 derived derive VBN 10_1101-2020_03_27_012757 878 4 xenografts xenograft NNS 10_1101-2020_03_27_012757 878 5 undergo undergo VBP 10_1101-2020_03_27_012757 878 6 mouse mouse NN 10_1101-2020_03_27_012757 878 7 - - HYPH 10_1101-2020_03_27_012757 878 8 specific specific JJ 10_1101-2020_03_27_012757 878 9 tumor tumor NN 10_1101-2020_03_27_012757 878 10 1159 1159 CD 10_1101-2020_03_27_012757 878 11 evolution evolution NN 10_1101-2020_03_27_012757 878 12 . . . 10_1101-2020_03_27_012757 879 1 Nat Nat NNP 10_1101-2020_03_27_012757 879 2 . . . 10_1101-2020_03_27_012757 880 1 Genet Genet NNP 10_1101-2020_03_27_012757 880 2 . . . 10_1101-2020_03_27_012757 881 1 49 49 CD 10_1101-2020_03_27_012757 881 2 , , , 10_1101-2020_03_27_012757 881 3 1567–1575 1567–1575 CD 10_1101-2020_03_27_012757 881 4 ( ( -LRB- 10_1101-2020_03_27_012757 881 5 2017 2017 CD 10_1101-2020_03_27_012757 881 6 ) ) -RRB- 10_1101-2020_03_27_012757 881 7 . . . 10_1101-2020_03_27_012757 882 1 1160 1160 CD 10_1101-2020_03_27_012757 882 2 74 74 CD 10_1101-2020_03_27_012757 882 3 . . . 10_1101-2020_03_27_012757 883 1 Stratton Stratton NNP 10_1101-2020_03_27_012757 883 2 , , , 10_1101-2020_03_27_012757 883 3 M. M. NNP 10_1101-2020_03_27_012757 883 4 R. R. NNP 10_1101-2020_03_27_012757 883 5 , , , 10_1101-2020_03_27_012757 883 6 Campbell Campbell NNP 10_1101-2020_03_27_012757 883 7 , , , 10_1101-2020_03_27_012757 883 8 P. P. NNP 10_1101-2020_03_27_012757 883 9 J. J. NNP 10_1101-2020_03_27_012757 884 1 & & CC 10_1101-2020_03_27_012757 884 2 Futreal Futreal NNP 10_1101-2020_03_27_012757 884 3 , , , 10_1101-2020_03_27_012757 884 4 P. P. NNP 10_1101-2020_03_27_012757 884 5 A. A. NNP 10_1101-2020_03_27_012757 885 1 The the DT 10_1101-2020_03_27_012757 885 2 cancer cancer NN 10_1101-2020_03_27_012757 885 3 genome genome NN 10_1101-2020_03_27_012757 885 4 . . . 10_1101-2020_03_27_012757 886 1 Nature nature NN 10_1101-2020_03_27_012757 886 2 458 458 CD 10_1101-2020_03_27_012757 886 3 , , , 10_1101-2020_03_27_012757 886 4 1161 1161 CD 10_1101-2020_03_27_012757 886 5 719–724 719–724 CD 10_1101-2020_03_27_012757 886 6 ( ( -LRB- 10_1101-2020_03_27_012757 886 7 2009 2009 CD 10_1101-2020_03_27_012757 886 8 ) ) -RRB- 10_1101-2020_03_27_012757 886 9 . . . 10_1101-2020_03_27_012757 887 1 1162 1162 CD 10_1101-2020_03_27_012757 887 2 75 75 CD 10_1101-2020_03_27_012757 887 3 . . . 10_1101-2020_03_27_012757 888 1 Balkwill Balkwill NNP 10_1101-2020_03_27_012757 888 2 , , , 10_1101-2020_03_27_012757 888 3 F. F. NNP 10_1101-2020_03_27_012757 888 4 R. R. NNP 10_1101-2020_03_27_012757 888 5 , , , 10_1101-2020_03_27_012757 888 6 Capasso Capasso NNP 10_1101-2020_03_27_012757 888 7 , , , 10_1101-2020_03_27_012757 888 8 M. M. NNP 10_1101-2020_03_27_012757 888 9 & & CC 10_1101-2020_03_27_012757 888 10 Hagemann Hagemann NNP 10_1101-2020_03_27_012757 888 11 , , , 10_1101-2020_03_27_012757 888 12 T. t. NN 10_1101-2020_03_27_012757 888 13 The the DT 10_1101-2020_03_27_012757 888 14 tumor tumor NN 10_1101-2020_03_27_012757 888 15 microenvironment microenvironment NN 10_1101-2020_03_27_012757 888 16 at at IN 10_1101-2020_03_27_012757 888 17 a a DT 10_1101-2020_03_27_012757 888 18 1163 1163 CD 10_1101-2020_03_27_012757 888 19 glance glance NN 10_1101-2020_03_27_012757 888 20 . . . 10_1101-2020_03_27_012757 889 1 J. J. NNP 10_1101-2020_03_27_012757 890 1 Cell Cell NNP 10_1101-2020_03_27_012757 890 2 Sci Sci NNP 10_1101-2020_03_27_012757 890 3 . . . 10_1101-2020_03_27_012757 891 1 125 125 CD 10_1101-2020_03_27_012757 891 2 , , , 10_1101-2020_03_27_012757 891 3 5591–5596 5591–5596 CD 10_1101-2020_03_27_012757 891 4 ( ( -LRB- 10_1101-2020_03_27_012757 891 5 2012 2012 CD 10_1101-2020_03_27_012757 891 6 ) ) -RRB- 10_1101-2020_03_27_012757 891 7 . . . 10_1101-2020_03_27_012757 892 1 1164 1164 CD 10_1101-2020_03_27_012757 892 2 76 76 CD 10_1101-2020_03_27_012757 892 3 . . . 10_1101-2020_03_27_012757 893 1 Lancaster Lancaster NNP 10_1101-2020_03_27_012757 893 2 , , , 10_1101-2020_03_27_012757 893 3 M. M. NNP 10_1101-2020_03_27_012757 893 4 A. A. NNP 10_1101-2020_03_27_012757 894 1 & & CC 10_1101-2020_03_27_012757 894 2 Knoblich Knoblich NNP 10_1101-2020_03_27_012757 894 3 , , , 10_1101-2020_03_27_012757 894 4 J. J. NNP 10_1101-2020_03_27_012757 895 1 A. A. NNP 10_1101-2020_03_27_012757 895 2 Organogenesis Organogenesis NNP 10_1101-2020_03_27_012757 895 3 in in IN 10_1101-2020_03_27_012757 895 4 a a DT 10_1101-2020_03_27_012757 895 5 dish dish NN 10_1101-2020_03_27_012757 895 6 : : : 10_1101-2020_03_27_012757 895 7 modeling model VBG 10_1101-2020_03_27_012757 895 8 development development NN 10_1101-2020_03_27_012757 895 9 1165 1165 CD 10_1101-2020_03_27_012757 895 10 and and CC 10_1101-2020_03_27_012757 895 11 disease disease NN 10_1101-2020_03_27_012757 895 12 using use VBG 10_1101-2020_03_27_012757 895 13 organoid organoid JJ 10_1101-2020_03_27_012757 895 14 technologies technology NNS 10_1101-2020_03_27_012757 895 15 . . . 10_1101-2020_03_27_012757 896 1 Science science NN 10_1101-2020_03_27_012757 896 2 345 345 CD 10_1101-2020_03_27_012757 896 3 , , , 10_1101-2020_03_27_012757 896 4 1247125 1247125 CD 10_1101-2020_03_27_012757 896 5 ( ( -LRB- 10_1101-2020_03_27_012757 896 6 2014 2014 CD 10_1101-2020_03_27_012757 896 7 ) ) -RRB- 10_1101-2020_03_27_012757 896 8 . . . 10_1101-2020_03_27_012757 897 1 1166 1166 CD 10_1101-2020_03_27_012757 897 2 77 77 CD 10_1101-2020_03_27_012757 897 3 . . . 10_1101-2020_03_27_012757 898 1 Bregenzer Bregenzer NNP 10_1101-2020_03_27_012757 898 2 , , , 10_1101-2020_03_27_012757 898 3 M. M. NNP 10_1101-2020_03_27_012757 898 4 E. E. NNP 10_1101-2020_03_27_012757 898 5 et et NNP 10_1101-2020_03_27_012757 898 6 al al NNP 10_1101-2020_03_27_012757 898 7 . . . 10_1101-2020_03_27_012757 899 1 Integrated integrate VBN 10_1101-2020_03_27_012757 899 2 cancer cancer NN 10_1101-2020_03_27_012757 899 3 tissue tissue NN 10_1101-2020_03_27_012757 899 4 engineering engineering NN 10_1101-2020_03_27_012757 899 5 models model NNS 10_1101-2020_03_27_012757 899 6 for for IN 10_1101-2020_03_27_012757 899 7 precision precision NN 10_1101-2020_03_27_012757 899 8 1167 1167 CD 10_1101-2020_03_27_012757 899 9 medicine medicine NN 10_1101-2020_03_27_012757 899 10 . . . 10_1101-2020_03_27_012757 900 1 PLoS plos ADD 10_1101-2020_03_27_012757 900 2 One one CD 10_1101-2020_03_27_012757 900 3 14 14 CD 10_1101-2020_03_27_012757 900 4 , , , 10_1101-2020_03_27_012757 900 5 e0216564 e0216564 NNP 10_1101-2020_03_27_012757 900 6 ( ( -LRB- 10_1101-2020_03_27_012757 900 7 2019 2019 CD 10_1101-2020_03_27_012757 900 8 ) ) -RRB- 10_1101-2020_03_27_012757 900 9 . . . 10_1101-2020_03_27_012757 901 1 1168 1168 CD 10_1101-2020_03_27_012757 901 2 78 78 CD 10_1101-2020_03_27_012757 901 3 . . . 10_1101-2020_03_27_012757 902 1 Wang Wang NNP 10_1101-2020_03_27_012757 902 2 , , , 10_1101-2020_03_27_012757 902 3 D. D. NNP 10_1101-2020_03_27_012757 902 4 H. H. NNP 10_1101-2020_03_27_012757 902 5 & & CC 10_1101-2020_03_27_012757 902 6 Souza Souza NNP 10_1101-2020_03_27_012757 902 7 , , , 10_1101-2020_03_27_012757 902 8 R. R. NNP 10_1101-2020_03_27_012757 902 9 F. F. NNP 10_1101-2020_03_27_012757 902 10 Biology Biology NNP 10_1101-2020_03_27_012757 902 11 of of IN 10_1101-2020_03_27_012757 902 12 Barrett Barrett NNP 10_1101-2020_03_27_012757 902 13 ’s ’s POS 10_1101-2020_03_27_012757 902 14 esophagus esophagus JJ 10_1101-2020_03_27_012757 902 15 and and CC 10_1101-2020_03_27_012757 902 16 esophageal esophageal JJ 10_1101-2020_03_27_012757 902 17 1169 1169 CD 10_1101-2020_03_27_012757 902 18 adenocarcinoma adenocarcinoma NN 10_1101-2020_03_27_012757 902 19 . . . 10_1101-2020_03_27_012757 903 1 Gastrointest Gastrointest NNP 10_1101-2020_03_27_012757 903 2 Endosc Endosc NNP 10_1101-2020_03_27_012757 903 3 Clin Clin NNP 10_1101-2020_03_27_012757 903 4 N N NNP 10_1101-2020_03_27_012757 903 5 Am Am NNP 10_1101-2020_03_27_012757 903 6 21 21 CD 10_1101-2020_03_27_012757 903 7 , , , 10_1101-2020_03_27_012757 903 8 25–38 25–38 CD 10_1101-2020_03_27_012757 903 9 ( ( -LRB- 10_1101-2020_03_27_012757 903 10 2011 2011 CD 10_1101-2020_03_27_012757 903 11 ) ) -RRB- 10_1101-2020_03_27_012757 903 12 . . . 10_1101-2020_03_27_012757 904 1 1170 1170 CD 10_1101-2020_03_27_012757 904 2 79 79 CD 10_1101-2020_03_27_012757 904 3 . . . 10_1101-2020_03_27_012757 905 1 Lee Lee NNP 10_1101-2020_03_27_012757 905 2 , , , 10_1101-2020_03_27_012757 905 3 J. J. NNP 10_1101-2020_03_27_012757 905 4 et et NNP 10_1101-2020_03_27_012757 905 5 al al NNP 10_1101-2020_03_27_012757 905 6 . . . 10_1101-2020_03_27_012757 906 1 Tumor tumor NN 10_1101-2020_03_27_012757 906 2 stem stem NN 10_1101-2020_03_27_012757 906 3 cells cell NNS 10_1101-2020_03_27_012757 906 4 derived derive VBN 10_1101-2020_03_27_012757 906 5 from from IN 10_1101-2020_03_27_012757 906 6 glioblastomas glioblastoma NNS 10_1101-2020_03_27_012757 906 7 cultured culture VBN 10_1101-2020_03_27_012757 906 8 in in IN 10_1101-2020_03_27_012757 906 9 bFGF bFGF NNP 10_1101-2020_03_27_012757 906 10 and and CC 10_1101-2020_03_27_012757 906 11 1171 1171 CD 10_1101-2020_03_27_012757 906 12 EGF EGF NNP 10_1101-2020_03_27_012757 906 13 more more RBR 10_1101-2020_03_27_012757 906 14 closely closely RB 10_1101-2020_03_27_012757 906 15 mirror mirror VBP 10_1101-2020_03_27_012757 906 16 the the DT 10_1101-2020_03_27_012757 906 17 phenotype phenotype NN 10_1101-2020_03_27_012757 906 18 and and CC 10_1101-2020_03_27_012757 906 19 genotype genotype NN 10_1101-2020_03_27_012757 906 20 of of IN 10_1101-2020_03_27_012757 906 21 primary primary JJ 10_1101-2020_03_27_012757 906 22 tumors tumor NNS 10_1101-2020_03_27_012757 906 23 than than IN 10_1101-2020_03_27_012757 906 24 do do VB 10_1101-2020_03_27_012757 906 25 1172 1172 CD 10_1101-2020_03_27_012757 906 26 serum serum NN 10_1101-2020_03_27_012757 906 27 - - HYPH 10_1101-2020_03_27_012757 906 28 cultured cultured JJ 10_1101-2020_03_27_012757 906 29 cell cell NN 10_1101-2020_03_27_012757 906 30 lines line NNS 10_1101-2020_03_27_012757 906 31 . . . 10_1101-2020_03_27_012757 907 1 Cancer Cancer NNP 10_1101-2020_03_27_012757 907 2 Cell Cell NNP 10_1101-2020_03_27_012757 907 3 9 9 CD 10_1101-2020_03_27_012757 907 4 , , , 10_1101-2020_03_27_012757 907 5 391–403 391–403 CD 10_1101-2020_03_27_012757 907 6 ( ( -LRB- 10_1101-2020_03_27_012757 907 7 2006 2006 CD 10_1101-2020_03_27_012757 907 8 ) ) -RRB- 10_1101-2020_03_27_012757 907 9 . . . 10_1101-2020_03_27_012757 908 1 1173 1173 CD 10_1101-2020_03_27_012757 908 2 80 80 CD 10_1101-2020_03_27_012757 908 3 . . . 10_1101-2020_03_27_012757 909 1 Wenger Wenger NNP 10_1101-2020_03_27_012757 909 2 , , , 10_1101-2020_03_27_012757 909 3 S. S. NNP 10_1101-2020_03_27_012757 909 4 L. L. NNP 10_1101-2020_03_27_012757 909 5 et et NNP 10_1101-2020_03_27_012757 909 6 al al NNP 10_1101-2020_03_27_012757 909 7 . . . 10_1101-2020_03_27_012757 910 1 Comparison comparison NN 10_1101-2020_03_27_012757 910 2 of of IN 10_1101-2020_03_27_012757 910 3 established establish VBN 10_1101-2020_03_27_012757 910 4 cell cell NN 10_1101-2020_03_27_012757 910 5 lines line NNS 10_1101-2020_03_27_012757 910 6 at at IN 10_1101-2020_03_27_012757 910 7 different different JJ 10_1101-2020_03_27_012757 910 8 passages passage NNS 10_1101-2020_03_27_012757 910 9 by by IN 10_1101-2020_03_27_012757 910 10 1174 1174 CD 10_1101-2020_03_27_012757 910 11 karyotype karyotype NNP 10_1101-2020_03_27_012757 910 12 and and CC 10_1101-2020_03_27_012757 910 13 comparative comparative JJ 10_1101-2020_03_27_012757 910 14 genomic genomic JJ 10_1101-2020_03_27_012757 910 15 hybridization hybridization NN 10_1101-2020_03_27_012757 910 16 . . . 10_1101-2020_03_27_012757 911 1 Biosci Biosci NNP 10_1101-2020_03_27_012757 911 2 . . . 10_1101-2020_03_27_012757 912 1 Rep. Rep. NNP 10_1101-2020_03_27_012757 912 2 24 24 CD 10_1101-2020_03_27_012757 912 3 , , , 10_1101-2020_03_27_012757 912 4 631–639 631–639 CD 10_1101-2020_03_27_012757 912 5 ( ( -LRB- 10_1101-2020_03_27_012757 912 6 2004 2004 CD 10_1101-2020_03_27_012757 912 7 ) ) -RRB- 10_1101-2020_03_27_012757 912 8 . . . 10_1101-2020_03_27_012757 913 1 1175 1175 CD 10_1101-2020_03_27_012757 913 2 81 81 CD 10_1101-2020_03_27_012757 913 3 . . . 10_1101-2020_03_27_012757 914 1 Ben Ben NNP 10_1101-2020_03_27_012757 914 2 - - HYPH 10_1101-2020_03_27_012757 914 3 David David NNP 10_1101-2020_03_27_012757 914 4 , , , 10_1101-2020_03_27_012757 914 5 U. U. NNP 10_1101-2020_03_27_012757 914 6 et et NNP 10_1101-2020_03_27_012757 914 7 al al NNP 10_1101-2020_03_27_012757 914 8 . . . 10_1101-2020_03_27_012757 915 1 Genetic genetic JJ 10_1101-2020_03_27_012757 915 2 and and CC 10_1101-2020_03_27_012757 915 3 transcriptional transcriptional JJ 10_1101-2020_03_27_012757 915 4 evolution evolution NN 10_1101-2020_03_27_012757 915 5 alters alter NNS 10_1101-2020_03_27_012757 915 6 cancer cancer NN 10_1101-2020_03_27_012757 915 7 cell cell NN 10_1101-2020_03_27_012757 915 8 line line NN 10_1101-2020_03_27_012757 915 9 drug drug NN 10_1101-2020_03_27_012757 915 10 1176 1176 CD 10_1101-2020_03_27_012757 915 11 response response NN 10_1101-2020_03_27_012757 915 12 . . . 10_1101-2020_03_27_012757 916 1 Nature nature NN 10_1101-2020_03_27_012757 916 2 560 560 CD 10_1101-2020_03_27_012757 916 3 , , , 10_1101-2020_03_27_012757 916 4 325–330 325–330 CD 10_1101-2020_03_27_012757 916 5 ( ( -LRB- 10_1101-2020_03_27_012757 916 6 2018 2018 CD 10_1101-2020_03_27_012757 916 7 ) ) -RRB- 10_1101-2020_03_27_012757 916 8 . . . 10_1101-2020_03_27_012757 917 1 1177 1177 CD 10_1101-2020_03_27_012757 917 2 82 82 CD 10_1101-2020_03_27_012757 917 3 . . . 10_1101-2020_03_27_012757 918 1 Cooke Cooke NNP 10_1101-2020_03_27_012757 918 2 , , , 10_1101-2020_03_27_012757 918 3 S. S. NNP 10_1101-2020_03_27_012757 918 4 L. L. NNP 10_1101-2020_03_27_012757 918 5 et et NNP 10_1101-2020_03_27_012757 918 6 al al NNP 10_1101-2020_03_27_012757 918 7 . . . 10_1101-2020_03_27_012757 919 1 Genomic genomic JJ 10_1101-2020_03_27_012757 919 2 analysis analysis NN 10_1101-2020_03_27_012757 919 3 of of IN 10_1101-2020_03_27_012757 919 4 genetic genetic JJ 10_1101-2020_03_27_012757 919 5 heterogeneity heterogeneity NN 10_1101-2020_03_27_012757 919 6 and and CC 10_1101-2020_03_27_012757 919 7 evolution evolution NN 10_1101-2020_03_27_012757 919 8 in in IN 10_1101-2020_03_27_012757 919 9 high-1178 high-1178 NNP 10_1101-2020_03_27_012757 919 10 grade grade NN 10_1101-2020_03_27_012757 919 11 serous serous JJ 10_1101-2020_03_27_012757 919 12 ovarian ovarian JJ 10_1101-2020_03_27_012757 919 13 carcinoma carcinoma NN 10_1101-2020_03_27_012757 919 14 . . . 10_1101-2020_03_27_012757 920 1 Oncogene oncogene NN 10_1101-2020_03_27_012757 920 2 29 29 CD 10_1101-2020_03_27_012757 920 3 , , , 10_1101-2020_03_27_012757 920 4 4905–4913 4905–4913 CD 10_1101-2020_03_27_012757 920 5 ( ( -LRB- 10_1101-2020_03_27_012757 920 6 2010 2010 CD 10_1101-2020_03_27_012757 920 7 ) ) -RRB- 10_1101-2020_03_27_012757 920 8 . . . 10_1101-2020_03_27_012757 921 1 1179 1179 CD 10_1101-2020_03_27_012757 921 2 83 83 CD 10_1101-2020_03_27_012757 921 3 . . . 10_1101-2020_03_27_012757 922 1 Hristova Hristova NNP 10_1101-2020_03_27_012757 922 2 , , , 10_1101-2020_03_27_012757 922 3 V. V. NNP 10_1101-2020_03_27_012757 922 4 A. A. NNP 10_1101-2020_03_27_012757 923 1 & & CC 10_1101-2020_03_27_012757 923 2 Chan Chan NNP 10_1101-2020_03_27_012757 923 3 , , , 10_1101-2020_03_27_012757 923 4 D. D. NNP 10_1101-2020_03_27_012757 923 5 W. W. NNP 10_1101-2020_03_27_012757 923 6 Cancer Cancer NNP 10_1101-2020_03_27_012757 923 7 biomarker biomarker NN 10_1101-2020_03_27_012757 923 8 discovery discovery NN 10_1101-2020_03_27_012757 923 9 and and CC 10_1101-2020_03_27_012757 923 10 translation translation NN 10_1101-2020_03_27_012757 923 11 : : : 10_1101-2020_03_27_012757 923 12 1180 1180 CD 10_1101-2020_03_27_012757 923 13 proteomics proteomic NNS 10_1101-2020_03_27_012757 923 14 and and CC 10_1101-2020_03_27_012757 923 15 beyond beyond IN 10_1101-2020_03_27_012757 923 16 . . . 10_1101-2020_03_27_012757 924 1 Expert expert NN 10_1101-2020_03_27_012757 924 2 Rev Rev NNP 10_1101-2020_03_27_012757 924 3 Proteomics Proteomics NNP 10_1101-2020_03_27_012757 924 4 16 16 CD 10_1101-2020_03_27_012757 924 5 , , , 10_1101-2020_03_27_012757 924 6 93–103 93–103 NNP 10_1101-2020_03_27_012757 924 7 ( ( -LRB- 10_1101-2020_03_27_012757 924 8 2019 2019 CD 10_1101-2020_03_27_012757 924 9 ) ) -RRB- 10_1101-2020_03_27_012757 924 10 . . . 10_1101-2020_03_27_012757 925 1 1181 1181 CD 10_1101-2020_03_27_012757 925 2 84 84 CD 10_1101-2020_03_27_012757 925 3 . . . 10_1101-2020_03_27_012757 926 1 Dawson Dawson NNP 10_1101-2020_03_27_012757 926 2 , , , 10_1101-2020_03_27_012757 926 3 M. M. NNP 10_1101-2020_03_27_012757 926 4 A. A. NNP 10_1101-2020_03_27_012757 927 1 & & CC 10_1101-2020_03_27_012757 927 2 Kouzarides Kouzarides NNP 10_1101-2020_03_27_012757 927 3 , , , 10_1101-2020_03_27_012757 927 4 T. T. NNP 10_1101-2020_03_27_012757 927 5 Cancer Cancer NNP 10_1101-2020_03_27_012757 927 6 epigenetics epigenetic NNS 10_1101-2020_03_27_012757 927 7 : : : 10_1101-2020_03_27_012757 927 8 from from IN 10_1101-2020_03_27_012757 927 9 mechanism mechanism NN 10_1101-2020_03_27_012757 927 10 to to IN 10_1101-2020_03_27_012757 927 11 therapy therapy NN 10_1101-2020_03_27_012757 927 12 . . . 10_1101-2020_03_27_012757 928 1 1182 1182 CD 10_1101-2020_03_27_012757 928 2 Cell Cell NNP 10_1101-2020_03_27_012757 928 3 150 150 CD 10_1101-2020_03_27_012757 928 4 , , , 10_1101-2020_03_27_012757 928 5 12–27 12–27 CD 10_1101-2020_03_27_012757 928 6 ( ( -LRB- 10_1101-2020_03_27_012757 928 7 2012 2012 CD 10_1101-2020_03_27_012757 928 8 ) ) -RRB- 10_1101-2020_03_27_012757 928 9 . . . 10_1101-2020_03_27_012757 929 1 1183 1183 CD 10_1101-2020_03_27_012757 929 2 85 85 CD 10_1101-2020_03_27_012757 929 3 . . . 10_1101-2020_03_27_012757 930 1 Silva silva NN 10_1101-2020_03_27_012757 930 2 , , , 10_1101-2020_03_27_012757 930 3 T. T. NNP 10_1101-2020_03_27_012757 930 4 C. C. NNP 10_1101-2020_03_27_012757 930 5 et et NNP 10_1101-2020_03_27_012757 930 6 al al NNP 10_1101-2020_03_27_012757 930 7 . . . 10_1101-2020_03_27_012757 931 1 TCGA TCGA NNP 10_1101-2020_03_27_012757 931 2 Workflow workflow NN 10_1101-2020_03_27_012757 931 3 : : : 10_1101-2020_03_27_012757 931 4 Analyze analyze VB 10_1101-2020_03_27_012757 931 5 cancer cancer NN 10_1101-2020_03_27_012757 931 6 genomics genomic NNS 10_1101-2020_03_27_012757 931 7 and and CC 10_1101-2020_03_27_012757 931 8 epigenomics epigenomic NNS 10_1101-2020_03_27_012757 931 9 data data NNP 10_1101-2020_03_27_012757 931 10 1184 1184 CD 10_1101-2020_03_27_012757 931 11 using use VBG 10_1101-2020_03_27_012757 931 12 Bioconductor Bioconductor NNP 10_1101-2020_03_27_012757 931 13 packages package NNS 10_1101-2020_03_27_012757 931 14 . . . 10_1101-2020_03_27_012757 932 1 [ [ -LRB- 10_1101-2020_03_27_012757 932 2 version version NN 10_1101-2020_03_27_012757 932 3 2 2 CD 10_1101-2020_03_27_012757 932 4 ; ; : 10_1101-2020_03_27_012757 932 5 peer peer NN 10_1101-2020_03_27_012757 932 6 review review NN 10_1101-2020_03_27_012757 932 7 : : : 10_1101-2020_03_27_012757 932 8 1 1 CD 10_1101-2020_03_27_012757 932 9 approved approve VBD 10_1101-2020_03_27_012757 932 10 , , , 10_1101-2020_03_27_012757 932 11 2 2 CD 10_1101-2020_03_27_012757 932 12 approved approve VBN 10_1101-2020_03_27_012757 932 13 with with IN 10_1101-2020_03_27_012757 932 14 1185 1185 CD 10_1101-2020_03_27_012757 932 15 reservations reservation NNS 10_1101-2020_03_27_012757 932 16 ] ] -RRB- 10_1101-2020_03_27_012757 932 17 . . . 10_1101-2020_03_27_012757 933 1 F1000Res f1000re NNS 10_1101-2020_03_27_012757 933 2 . . . 10_1101-2020_03_27_012757 934 1 5 5 CD 10_1101-2020_03_27_012757 934 2 , , , 10_1101-2020_03_27_012757 934 3 1542 1542 CD 10_1101-2020_03_27_012757 934 4 ( ( -LRB- 10_1101-2020_03_27_012757 934 5 2016 2016 CD 10_1101-2020_03_27_012757 934 6 ) ) -RRB- 10_1101-2020_03_27_012757 934 7 . . . 10_1101-2020_03_27_012757 935 1 1186 1186 CD 10_1101-2020_03_27_012757 935 2 86 86 CD 10_1101-2020_03_27_012757 935 3 . . . 10_1101-2020_03_27_012757 936 1 Morgan Morgan NNP 10_1101-2020_03_27_012757 936 2 , , , 10_1101-2020_03_27_012757 936 3 M. M. NNP 10_1101-2020_03_27_012757 936 4 , , , 10_1101-2020_03_27_012757 936 5 Obenchain Obenchain NNP 10_1101-2020_03_27_012757 936 6 , , , 10_1101-2020_03_27_012757 936 7 V. V. NNP 10_1101-2020_03_27_012757 936 8 , , , 10_1101-2020_03_27_012757 936 9 Hester Hester NNP 10_1101-2020_03_27_012757 936 10 , , , 10_1101-2020_03_27_012757 936 11 J. J. NNP 10_1101-2020_03_27_012757 937 1 & & CC 10_1101-2020_03_27_012757 937 2 Pag`es Pag`es NNP 10_1101-2020_03_27_012757 937 3 , , , 10_1101-2020_03_27_012757 937 4 H. H. NNP 10_1101-2020_03_27_012757 937 5 SummarizedExperiment SummarizedExperiment NNP 10_1101-2020_03_27_012757 937 6 : : : 10_1101-2020_03_27_012757 937 7 1187 1187 CD 10_1101-2020_03_27_012757 937 8 SummarizedExperiment SummarizedExperiment NNP 10_1101-2020_03_27_012757 937 9 container container NN 10_1101-2020_03_27_012757 937 10 . . . 10_1101-2020_03_27_012757 938 1 ( ( -LRB- 10_1101-2020_03_27_012757 938 2 2018 2018 CD 10_1101-2020_03_27_012757 938 3 ) ) -RRB- 10_1101-2020_03_27_012757 938 4 . . . 10_1101-2020_03_27_012757 939 1 1188 1188 CD 10_1101-2020_03_27_012757 939 2 .CC .CC : 10_1101-2020_03_27_012757 939 3 - - : 10_1101-2020_03_27_012757 939 4 BY by IN 10_1101-2020_03_27_012757 939 5 - - HYPH 10_1101-2020_03_27_012757 939 6 NC NC NNP 10_1101-2020_03_27_012757 939 7 - - HYPH 10_1101-2020_03_27_012757 939 8 ND ND NNP 10_1101-2020_03_27_012757 939 9 4.0 4.0 CD 10_1101-2020_03_27_012757 939 10 International International NNP 10_1101-2020_03_27_012757 939 11 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 939 12 under under IN 10_1101-2020_03_27_012757 939 13 a a DT 10_1101-2020_03_27_012757 939 14 ( ( -LRB- 10_1101-2020_03_27_012757 939 15 which which WDT 10_1101-2020_03_27_012757 939 16 was be VBD 10_1101-2020_03_27_012757 939 17 not not RB 10_1101-2020_03_27_012757 939 18 certified certify VBN 10_1101-2020_03_27_012757 939 19 by by IN 10_1101-2020_03_27_012757 939 20 peer peer NN 10_1101-2020_03_27_012757 939 21 review review NN 10_1101-2020_03_27_012757 939 22 ) ) -RRB- 10_1101-2020_03_27_012757 939 23 is be VBZ 10_1101-2020_03_27_012757 939 24 the the DT 10_1101-2020_03_27_012757 939 25 author author NN 10_1101-2020_03_27_012757 939 26 / / SYM 10_1101-2020_03_27_012757 939 27 funder funder NN 10_1101-2020_03_27_012757 939 28 , , , 10_1101-2020_03_27_012757 939 29 who who WP 10_1101-2020_03_27_012757 939 30 has have VBZ 10_1101-2020_03_27_012757 939 31 granted grant VBN 10_1101-2020_03_27_012757 939 32 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 939 33 a a DT 10_1101-2020_03_27_012757 939 34 license license NN 10_1101-2020_03_27_012757 939 35 to to TO 10_1101-2020_03_27_012757 939 36 display display VB 10_1101-2020_03_27_012757 939 37 the the DT 10_1101-2020_03_27_012757 939 38 preprint preprint NN 10_1101-2020_03_27_012757 939 39 in in IN 10_1101-2020_03_27_012757 939 40 perpetuity perpetuity NN 10_1101-2020_03_27_012757 939 41 . . . 10_1101-2020_03_27_012757 940 1 It -PRON- PRP 10_1101-2020_03_27_012757 940 2 is be VBZ 10_1101-2020_03_27_012757 940 3 made make VBN 10_1101-2020_03_27_012757 940 4 The the DT 10_1101-2020_03_27_012757 940 5 copyright copyright NN 10_1101-2020_03_27_012757 940 6 holder holder NN 10_1101-2020_03_27_012757 940 7 for for IN 10_1101-2020_03_27_012757 940 8 this this DT 10_1101-2020_03_27_012757 940 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 940 10 version version NN 10_1101-2020_03_27_012757 940 11 posted post VBD 10_1101-2020_03_27_012757 940 12 January January NNP 10_1101-2020_03_27_012757 940 13 9 9 CD 10_1101-2020_03_27_012757 940 14 , , , 10_1101-2020_03_27_012757 940 15 2021 2021 CD 10_1101-2020_03_27_012757 940 16 . . . 10_1101-2020_03_27_012757 940 17 ; ; : 10_1101-2020_03_27_012757 940 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 940 19 : : : 10_1101-2020_03_27_012757 940 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 940 21 preprint preprint NN 10_1101-2020_03_27_012757 940 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 940 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2020_03_27_012757 940 24 42 42 CD 10_1101-2020_03_27_012757 940 25 87 87 CD 10_1101-2020_03_27_012757 940 26 . . . 10_1101-2020_03_27_012757 941 1 Pavlidis Pavlidis NNP 10_1101-2020_03_27_012757 941 2 , , , 10_1101-2020_03_27_012757 941 3 P. P. NNP 10_1101-2020_03_27_012757 941 4 & & CC 10_1101-2020_03_27_012757 941 5 Noble Noble NNP 10_1101-2020_03_27_012757 941 6 , , , 10_1101-2020_03_27_012757 941 7 W. W. NNP 10_1101-2020_03_27_012757 941 8 S. S. NNP 10_1101-2020_03_27_012757 941 9 Analysis Analysis NNP 10_1101-2020_03_27_012757 941 10 of of IN 10_1101-2020_03_27_012757 941 11 strain strain NN 10_1101-2020_03_27_012757 941 12 and and CC 10_1101-2020_03_27_012757 941 13 regional regional JJ 10_1101-2020_03_27_012757 941 14 variation variation NN 10_1101-2020_03_27_012757 941 15 in in IN 10_1101-2020_03_27_012757 941 16 gene gene NN 10_1101-2020_03_27_012757 941 17 1189 1189 CD 10_1101-2020_03_27_012757 941 18 expression expression NN 10_1101-2020_03_27_012757 941 19 in in IN 10_1101-2020_03_27_012757 941 20 mouse mouse NN 10_1101-2020_03_27_012757 941 21 brain brain NN 10_1101-2020_03_27_012757 941 22 . . . 10_1101-2020_03_27_012757 942 1 Genome Genome NNP 10_1101-2020_03_27_012757 942 2 Biol Biol NNP 10_1101-2020_03_27_012757 942 3 . . . 10_1101-2020_03_27_012757 943 1 2 2 LS 10_1101-2020_03_27_012757 943 2 , , , 10_1101-2020_03_27_012757 943 3 RESEARCH0042 RESEARCH0042 NNP 10_1101-2020_03_27_012757 943 4 ( ( -LRB- 10_1101-2020_03_27_012757 943 5 2001 2001 CD 10_1101-2020_03_27_012757 943 6 ) ) -RRB- 10_1101-2020_03_27_012757 943 7 . . . 10_1101-2020_03_27_012757 944 1 1190 1190 CD 10_1101-2020_03_27_012757 944 2 88 88 CD 10_1101-2020_03_27_012757 944 3 . . . 10_1101-2020_03_27_012757 945 1 Geman Geman NNP 10_1101-2020_03_27_012757 945 2 , , , 10_1101-2020_03_27_012757 945 3 D. D. NNP 10_1101-2020_03_27_012757 945 4 , , , 10_1101-2020_03_27_012757 945 5 d d NNP 10_1101-2020_03_27_012757 945 6 Avignon Avignon NNP 10_1101-2020_03_27_012757 945 7 , , , 10_1101-2020_03_27_012757 945 8 C. C. NNP 10_1101-2020_03_27_012757 945 9 , , , 10_1101-2020_03_27_012757 945 10 Naiman Naiman NNP 10_1101-2020_03_27_012757 945 11 , , , 10_1101-2020_03_27_012757 945 12 D. D. NNP 10_1101-2020_03_27_012757 945 13 Q. Q. NNP 10_1101-2020_03_27_012757 946 1 & & CC 10_1101-2020_03_27_012757 946 2 Winslow Winslow NNP 10_1101-2020_03_27_012757 946 3 , , , 10_1101-2020_03_27_012757 946 4 R. R. NNP 10_1101-2020_03_27_012757 946 5 L. L. NNP 10_1101-2020_03_27_012757 946 6 Classifying Classifying NNP 10_1101-2020_03_27_012757 946 7 gene gene NN 10_1101-2020_03_27_012757 946 8 1191 1191 CD 10_1101-2020_03_27_012757 946 9 expression expression NN 10_1101-2020_03_27_012757 946 10 profiles profile NNS 10_1101-2020_03_27_012757 946 11 from from IN 10_1101-2020_03_27_012757 946 12 pairwise pairwise NN 10_1101-2020_03_27_012757 946 13 mRNA mRNA NNP 10_1101-2020_03_27_012757 946 14 comparisons comparison NNS 10_1101-2020_03_27_012757 946 15 . . . 10_1101-2020_03_27_012757 947 1 Stat stat JJ 10_1101-2020_03_27_012757 947 2 Appl Appl NNP 10_1101-2020_03_27_012757 947 3 Genet Genet NNP 10_1101-2020_03_27_012757 947 4 Mol Mol NNP 10_1101-2020_03_27_012757 947 5 Biol Biol NNP 10_1101-2020_03_27_012757 947 6 3 3 CD 10_1101-2020_03_27_012757 947 7 , , , 10_1101-2020_03_27_012757 947 8 1192 1192 CD 10_1101-2020_03_27_012757 947 9 Article19 Article19 NNP 10_1101-2020_03_27_012757 947 10 ( ( -LRB- 10_1101-2020_03_27_012757 947 11 2004 2004 CD 10_1101-2020_03_27_012757 947 12 ) ) -RRB- 10_1101-2020_03_27_012757 947 13 . . . 10_1101-2020_03_27_012757 948 1 1193 1193 CD 10_1101-2020_03_27_012757 948 2 89 89 CD 10_1101-2020_03_27_012757 948 3 . . . 10_1101-2020_03_27_012757 949 1 Krstajic Krstajic NNP 10_1101-2020_03_27_012757 949 2 , , , 10_1101-2020_03_27_012757 949 3 D. D. NNP 10_1101-2020_03_27_012757 949 4 , , , 10_1101-2020_03_27_012757 949 5 Buturovic Buturovic NNP 10_1101-2020_03_27_012757 949 6 , , , 10_1101-2020_03_27_012757 949 7 L. L. NNP 10_1101-2020_03_27_012757 949 8 J. J. NNP 10_1101-2020_03_27_012757 949 9 , , , 10_1101-2020_03_27_012757 949 10 Leahy Leahy NNP 10_1101-2020_03_27_012757 949 11 , , , 10_1101-2020_03_27_012757 949 12 D. D. NNP 10_1101-2020_03_27_012757 949 13 E. E. NNP 10_1101-2020_03_27_012757 949 14 & & CC 10_1101-2020_03_27_012757 949 15 Thomas Thomas NNP 10_1101-2020_03_27_012757 949 16 , , , 10_1101-2020_03_27_012757 949 17 S. S. NNP 10_1101-2020_03_27_012757 949 18 Cross Cross NNP 10_1101-2020_03_27_012757 949 19 - - NN 10_1101-2020_03_27_012757 949 20 validation validation NN 10_1101-2020_03_27_012757 949 21 pitfalls pitfall NNS 10_1101-2020_03_27_012757 949 22 1194 1194 CD 10_1101-2020_03_27_012757 949 23 when when WRB 10_1101-2020_03_27_012757 949 24 selecting select VBG 10_1101-2020_03_27_012757 949 25 and and CC 10_1101-2020_03_27_012757 949 26 assessing assess VBG 10_1101-2020_03_27_012757 949 27 regression regression NN 10_1101-2020_03_27_012757 949 28 and and CC 10_1101-2020_03_27_012757 949 29 classification classification NN 10_1101-2020_03_27_012757 949 30 models model NNS 10_1101-2020_03_27_012757 949 31 . . . 10_1101-2020_03_27_012757 950 1 J. J. NNP 10_1101-2020_03_27_012757 950 2 Cheminform Cheminform NNP 10_1101-2020_03_27_012757 950 3 . . . 10_1101-2020_03_27_012757 951 1 1195 1195 CD 10_1101-2020_03_27_012757 951 2 6 6 CD 10_1101-2020_03_27_012757 951 3 , , , 10_1101-2020_03_27_012757 951 4 10 10 CD 10_1101-2020_03_27_012757 951 5 ( ( -LRB- 10_1101-2020_03_27_012757 951 6 2014 2014 CD 10_1101-2020_03_27_012757 951 7 ) ) -RRB- 10_1101-2020_03_27_012757 951 8 . . . 10_1101-2020_03_27_012757 952 1 1196 1196 CD 10_1101-2020_03_27_012757 952 2 90 90 CD 10_1101-2020_03_27_012757 952 3 . . . 10_1101-2020_03_27_012757 953 1 Lipton Lipton NNP 10_1101-2020_03_27_012757 953 2 , , , 10_1101-2020_03_27_012757 953 3 Z. Z. NNP 10_1101-2020_03_27_012757 953 4 C. C. NNP 10_1101-2020_03_27_012757 953 5 , , , 10_1101-2020_03_27_012757 953 6 Elkan Elkan NNP 10_1101-2020_03_27_012757 953 7 , , , 10_1101-2020_03_27_012757 953 8 C. C. NNP 10_1101-2020_03_27_012757 953 9 & & CC 10_1101-2020_03_27_012757 953 10 Naryanaswamy Naryanaswamy NNP 10_1101-2020_03_27_012757 953 11 , , , 10_1101-2020_03_27_012757 953 12 B. B. NNP 10_1101-2020_03_27_012757 953 13 Optimal Optimal NNP 10_1101-2020_03_27_012757 953 14 Thresholding Thresholding NNP 10_1101-2020_03_27_012757 953 15 of of IN 10_1101-2020_03_27_012757 953 16 Classifiers Classifiers NNPS 10_1101-2020_03_27_012757 953 17 to to IN 10_1101-2020_03_27_012757 953 18 1197 1197 CD 10_1101-2020_03_27_012757 953 19 Maximize Maximize NNP 10_1101-2020_03_27_012757 953 20 F1 F1 NNP 10_1101-2020_03_27_012757 953 21 Measure measure NN 10_1101-2020_03_27_012757 953 22 . . . 10_1101-2020_03_27_012757 954 1 Mach Mach NNP 10_1101-2020_03_27_012757 954 2 . . . 10_1101-2020_03_27_012757 955 1 Learn learn VB 10_1101-2020_03_27_012757 955 2 . . . 10_1101-2020_03_27_012757 956 1 Knowl Knowl NNP 10_1101-2020_03_27_012757 956 2 . . . 10_1101-2020_03_27_012757 957 1 Discov Discov NNP 10_1101-2020_03_27_012757 957 2 . . . 10_1101-2020_03_27_012757 958 1 Databases Databases NNP 10_1101-2020_03_27_012757 958 2 8725 8725 CD 10_1101-2020_03_27_012757 958 3 , , , 10_1101-2020_03_27_012757 958 4 225–239 225–239 CD 10_1101-2020_03_27_012757 958 5 1198 1198 CD 10_1101-2020_03_27_012757 958 6 ( ( -LRB- 10_1101-2020_03_27_012757 958 7 2014 2014 CD 10_1101-2020_03_27_012757 958 8 ) ) -RRB- 10_1101-2020_03_27_012757 958 9 . . . 10_1101-2020_03_27_012757 959 1 1199 1199 CD 10_1101-2020_03_27_012757 959 2 91 91 CD 10_1101-2020_03_27_012757 959 3 . . . 10_1101-2020_03_27_012757 960 1 Grow grow VB 10_1101-2020_03_27_012757 960 2 , , , 10_1101-2020_03_27_012757 960 3 E. E. NNP 10_1101-2020_03_27_012757 960 4 J. J. NNP 10_1101-2020_03_27_012757 960 5 et et NNP 10_1101-2020_03_27_012757 960 6 al al NNP 10_1101-2020_03_27_012757 960 7 . . . 10_1101-2020_03_27_012757 961 1 Intrinsic intrinsic JJ 10_1101-2020_03_27_012757 961 2 retroviral retroviral JJ 10_1101-2020_03_27_012757 961 3 reactivation reactivation NN 10_1101-2020_03_27_012757 961 4 in in IN 10_1101-2020_03_27_012757 961 5 human human JJ 10_1101-2020_03_27_012757 961 6 preimplantation preimplantation NN 10_1101-2020_03_27_012757 961 7 embryos embryo NNS 10_1101-2020_03_27_012757 961 8 1200 1200 CD 10_1101-2020_03_27_012757 961 9 and and CC 10_1101-2020_03_27_012757 961 10 pluripotent pluripotent NN 10_1101-2020_03_27_012757 961 11 cells cell NNS 10_1101-2020_03_27_012757 961 12 . . . 10_1101-2020_03_27_012757 962 1 Nature nature NN 10_1101-2020_03_27_012757 962 2 522 522 CD 10_1101-2020_03_27_012757 962 3 , , , 10_1101-2020_03_27_012757 962 4 221–225 221–225 CD 10_1101-2020_03_27_012757 962 5 ( ( -LRB- 10_1101-2020_03_27_012757 962 6 2015 2015 CD 10_1101-2020_03_27_012757 962 7 ) ) -RRB- 10_1101-2020_03_27_012757 962 8 . . . 10_1101-2020_03_27_012757 963 1 1201 1201 CD 10_1101-2020_03_27_012757 963 2 92 92 CD 10_1101-2020_03_27_012757 963 3 . . . 10_1101-2020_03_27_012757 964 1 Kolde Kolde NNP 10_1101-2020_03_27_012757 964 2 , , , 10_1101-2020_03_27_012757 964 3 R. R. NNP 10_1101-2020_03_27_012757 964 4 pheatmap pheatmap NN 10_1101-2020_03_27_012757 964 5 : : : 10_1101-2020_03_27_012757 964 6 Pretty Pretty NNP 10_1101-2020_03_27_012757 964 7 Heatmaps Heatmaps NNP 10_1101-2020_03_27_012757 964 8 . . . 10_1101-2020_03_27_012757 965 1 ( ( -LRB- 10_1101-2020_03_27_012757 965 2 CRAN CRAN NNP 10_1101-2020_03_27_012757 965 3 , , , 10_1101-2020_03_27_012757 965 4 2019 2019 CD 10_1101-2020_03_27_012757 965 5 ) ) -RRB- 10_1101-2020_03_27_012757 965 6 . . . 10_1101-2020_03_27_012757 966 1 1202 1202 CD 10_1101-2020_03_27_012757 966 2 93 93 CD 10_1101-2020_03_27_012757 966 3 . . . 10_1101-2020_03_27_012757 967 1 Wickham Wickham NNP 10_1101-2020_03_27_012757 967 2 , , , 10_1101-2020_03_27_012757 967 3 H. H. NNP 10_1101-2020_03_27_012757 967 4 ggplot2 ggplot2 NN 10_1101-2020_03_27_012757 967 5 - - HYPH 10_1101-2020_03_27_012757 967 6 Elegant elegant JJ 10_1101-2020_03_27_012757 967 7 Graphics Graphics NNPS 10_1101-2020_03_27_012757 967 8 for for IN 10_1101-2020_03_27_012757 967 9 Data Data NNP 10_1101-2020_03_27_012757 967 10 Analysis Analysis NNP 10_1101-2020_03_27_012757 967 11 . . . 10_1101-2020_03_27_012757 968 1 ( ( -LRB- 10_1101-2020_03_27_012757 968 2 Springer Springer NNP 10_1101-2020_03_27_012757 968 3 - - HYPH 10_1101-2020_03_27_012757 968 4 Verlag Verlag NNP 10_1101-2020_03_27_012757 968 5 New New NNP 10_1101-2020_03_27_012757 968 6 1203 1203 CD 10_1101-2020_03_27_012757 968 7 York York NNP 10_1101-2020_03_27_012757 968 8 , , , 10_1101-2020_03_27_012757 968 9 2016 2016 CD 10_1101-2020_03_27_012757 968 10 ) ) -RRB- 10_1101-2020_03_27_012757 968 11 . . . 10_1101-2020_03_27_012757 969 1 doi:10.1007/978 doi:10.1007/978 LS 10_1101-2020_03_27_012757 969 2 - - HYPH 10_1101-2020_03_27_012757 969 3 0 0 CD 10_1101-2020_03_27_012757 969 4 - - HYPH 10_1101-2020_03_27_012757 969 5 387 387 CD 10_1101-2020_03_27_012757 969 6 - - HYPH 10_1101-2020_03_27_012757 969 7 98141 98141 CD 10_1101-2020_03_27_012757 969 8 - - HYPH 10_1101-2020_03_27_012757 969 9 3 3 CD 10_1101-2020_03_27_012757 969 10 1204 1204 CD 10_1101-2020_03_27_012757 969 11 94 94 CD 10_1101-2020_03_27_012757 969 12 . . . 10_1101-2020_03_27_012757 970 1 Gu Gu NNP 10_1101-2020_03_27_012757 970 2 , , , 10_1101-2020_03_27_012757 970 3 Z. Z. NNP 10_1101-2020_03_27_012757 970 4 , , , 10_1101-2020_03_27_012757 970 5 Eils Eils NNP 10_1101-2020_03_27_012757 970 6 , , , 10_1101-2020_03_27_012757 970 7 R. R. NNP 10_1101-2020_03_27_012757 970 8 & & CC 10_1101-2020_03_27_012757 970 9 Schlesner Schlesner NNP 10_1101-2020_03_27_012757 970 10 , , , 10_1101-2020_03_27_012757 970 11 M. M. NNP 10_1101-2020_03_27_012757 970 12 Complex Complex NNP 10_1101-2020_03_27_012757 970 13 heatmaps heatmap NNS 10_1101-2020_03_27_012757 970 14 reveal reveal VBP 10_1101-2020_03_27_012757 970 15 patterns pattern NNS 10_1101-2020_03_27_012757 970 16 and and CC 10_1101-2020_03_27_012757 970 17 correlations correlation NNS 10_1101-2020_03_27_012757 970 18 1205 1205 CD 10_1101-2020_03_27_012757 970 19 in in IN 10_1101-2020_03_27_012757 970 20 multidimensional multidimensional JJ 10_1101-2020_03_27_012757 970 21 genomic genomic JJ 10_1101-2020_03_27_012757 970 22 data datum NNS 10_1101-2020_03_27_012757 970 23 . . . 10_1101-2020_03_27_012757 971 1 Bioinformatics Bioinformatics NNP 10_1101-2020_03_27_012757 971 2 32 32 CD 10_1101-2020_03_27_012757 971 3 , , , 10_1101-2020_03_27_012757 971 4 2847–2849 2847–2849 CD 10_1101-2020_03_27_012757 971 5 ( ( -LRB- 10_1101-2020_03_27_012757 971 6 2016 2016 CD 10_1101-2020_03_27_012757 971 7 ) ) -RRB- 10_1101-2020_03_27_012757 971 8 . . . 10_1101-2020_03_27_012757 972 1 1206 1206 CD 10_1101-2020_03_27_012757 972 2 95 95 CD 10_1101-2020_03_27_012757 972 3 . . . 10_1101-2020_03_27_012757 973 1 Yoshihara Yoshihara NNP 10_1101-2020_03_27_012757 973 2 , , , 10_1101-2020_03_27_012757 973 3 K. K. NNP 10_1101-2020_03_27_012757 973 4 et et NNP 10_1101-2020_03_27_012757 973 5 al al NNP 10_1101-2020_03_27_012757 973 6 . . . 10_1101-2020_03_27_012757 974 1 Inferring infer VBG 10_1101-2020_03_27_012757 974 2 tumour tumour NN 10_1101-2020_03_27_012757 974 3 purity purity NN 10_1101-2020_03_27_012757 974 4 and and CC 10_1101-2020_03_27_012757 974 5 stromal stromal NN 10_1101-2020_03_27_012757 974 6 and and CC 10_1101-2020_03_27_012757 974 7 immune immune JJ 10_1101-2020_03_27_012757 974 8 cell cell NN 10_1101-2020_03_27_012757 974 9 admixture admixture NN 10_1101-2020_03_27_012757 974 10 1207 1207 CD 10_1101-2020_03_27_012757 974 11 from from IN 10_1101-2020_03_27_012757 974 12 expression expression NN 10_1101-2020_03_27_012757 974 13 data datum NNS 10_1101-2020_03_27_012757 974 14 . . . 10_1101-2020_03_27_012757 975 1 Nat Nat NNP 10_1101-2020_03_27_012757 975 2 . . . 10_1101-2020_03_27_012757 976 1 Commun Commun VBN 10_1101-2020_03_27_012757 976 2 . . . 10_1101-2020_03_27_012757 977 1 4 4 CD 10_1101-2020_03_27_012757 977 2 , , , 10_1101-2020_03_27_012757 977 3 2612 2612 CD 10_1101-2020_03_27_012757 977 4 ( ( -LRB- 10_1101-2020_03_27_012757 977 5 2013 2013 CD 10_1101-2020_03_27_012757 977 6 ) ) -RRB- 10_1101-2020_03_27_012757 977 7 . . . 10_1101-2020_03_27_012757 978 1 1208 1208 CD 10_1101-2020_03_27_012757 978 2 96 96 CD 10_1101-2020_03_27_012757 978 3 . . . 10_1101-2020_03_27_012757 979 1 Kovalchik Kovalchik NNP 10_1101-2020_03_27_012757 979 2 , , , 10_1101-2020_03_27_012757 979 3 S. S. NNP 10_1101-2020_03_27_012757 979 4 RISmed RISmed NNP 10_1101-2020_03_27_012757 979 5 : : : 10_1101-2020_03_27_012757 979 6 Download Download NNP 10_1101-2020_03_27_012757 979 7 Content Content NNP 10_1101-2020_03_27_012757 979 8 from from IN 10_1101-2020_03_27_012757 979 9 NCBI NCBI NNP 10_1101-2020_03_27_012757 979 10 Databases Databases NNP 10_1101-2020_03_27_012757 979 11 . . . 10_1101-2020_03_27_012757 980 1 ( ( -LRB- 10_1101-2020_03_27_012757 980 2 CRAN.R CRAN.R NNP 10_1101-2020_03_27_012757 980 3 - - HYPH 10_1101-2020_03_27_012757 980 4 project project NN 10_1101-2020_03_27_012757 980 5 , , , 10_1101-2020_03_27_012757 980 6 1209 1209 CD 10_1101-2020_03_27_012757 980 7 2017 2017 CD 10_1101-2020_03_27_012757 980 8 ) ) -RRB- 10_1101-2020_03_27_012757 980 9 . . . 10_1101-2020_03_27_012757 981 1 1210 1210 CD 10_1101-2020_03_27_012757 981 2 1211 1211 CD 10_1101-2020_03_27_012757 981 3 .CC .CC : 10_1101-2020_03_27_012757 981 4 - - : 10_1101-2020_03_27_012757 981 5 BY by IN 10_1101-2020_03_27_012757 981 6 - - HYPH 10_1101-2020_03_27_012757 981 7 NC NC NNP 10_1101-2020_03_27_012757 981 8 - - HYPH 10_1101-2020_03_27_012757 981 9 ND ND NNP 10_1101-2020_03_27_012757 981 10 4.0 4.0 CD 10_1101-2020_03_27_012757 981 11 International International NNP 10_1101-2020_03_27_012757 981 12 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 981 13 under under IN 10_1101-2020_03_27_012757 981 14 a a DT 10_1101-2020_03_27_012757 981 15 ( ( -LRB- 10_1101-2020_03_27_012757 981 16 which which WDT 10_1101-2020_03_27_012757 981 17 was be VBD 10_1101-2020_03_27_012757 981 18 not not RB 10_1101-2020_03_27_012757 981 19 certified certify VBN 10_1101-2020_03_27_012757 981 20 by by IN 10_1101-2020_03_27_012757 981 21 peer peer NN 10_1101-2020_03_27_012757 981 22 review review NN 10_1101-2020_03_27_012757 981 23 ) ) -RRB- 10_1101-2020_03_27_012757 981 24 is be VBZ 10_1101-2020_03_27_012757 981 25 the the DT 10_1101-2020_03_27_012757 981 26 author author NN 10_1101-2020_03_27_012757 981 27 / / SYM 10_1101-2020_03_27_012757 981 28 funder funder NN 10_1101-2020_03_27_012757 981 29 , , , 10_1101-2020_03_27_012757 981 30 who who WP 10_1101-2020_03_27_012757 981 31 has have VBZ 10_1101-2020_03_27_012757 981 32 granted grant VBN 10_1101-2020_03_27_012757 981 33 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 981 34 a a DT 10_1101-2020_03_27_012757 981 35 license license NN 10_1101-2020_03_27_012757 981 36 to to TO 10_1101-2020_03_27_012757 981 37 display display VB 10_1101-2020_03_27_012757 981 38 the the DT 10_1101-2020_03_27_012757 981 39 preprint preprint NN 10_1101-2020_03_27_012757 981 40 in in IN 10_1101-2020_03_27_012757 981 41 perpetuity perpetuity NN 10_1101-2020_03_27_012757 981 42 . . . 10_1101-2020_03_27_012757 982 1 It -PRON- PRP 10_1101-2020_03_27_012757 982 2 is be VBZ 10_1101-2020_03_27_012757 982 3 made make VBN 10_1101-2020_03_27_012757 982 4 The the DT 10_1101-2020_03_27_012757 982 5 copyright copyright NN 10_1101-2020_03_27_012757 982 6 holder holder NN 10_1101-2020_03_27_012757 982 7 for for IN 10_1101-2020_03_27_012757 982 8 this this DT 10_1101-2020_03_27_012757 982 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 982 10 version version NN 10_1101-2020_03_27_012757 982 11 posted post VBD 10_1101-2020_03_27_012757 982 12 January January NNP 10_1101-2020_03_27_012757 982 13 9 9 CD 10_1101-2020_03_27_012757 982 14 , , , 10_1101-2020_03_27_012757 982 15 2021 2021 CD 10_1101-2020_03_27_012757 982 16 . . . 10_1101-2020_03_27_012757 982 17 ; ; : 10_1101-2020_03_27_012757 982 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 982 19 : : : 10_1101-2020_03_27_012757 982 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 982 21 preprint preprint NN 10_1101-2020_03_27_012757 982 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 982 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 982 24 A a DT 10_1101-2020_03_27_012757 982 25 B B NNP 10_1101-2020_03_27_012757 982 26 Figure figure NN 10_1101-2020_03_27_012757 982 27 1 1 CD 10_1101-2020_03_27_012757 982 28 HighLow HighLow NNP 10_1101-2020_03_27_012757 982 29 C C NNP 10_1101-2020_03_27_012757 982 30 an an DT 10_1101-2020_03_27_012757 982 31 ce ce NNP 10_1101-2020_03_27_012757 982 32 r r NN 10_1101-2020_03_27_012757 982 33 T t NN 10_1101-2020_03_27_012757 982 34 yp yp NN 10_1101-2020_03_27_012757 982 35 es es XX 10_1101-2020_03_27_012757 982 36 Cancer Cancer NNP 10_1101-2020_03_27_012757 982 37 models model NNS 10_1101-2020_03_27_012757 982 38 Classification classification NN 10_1101-2020_03_27_012757 982 39 score score NN 10_1101-2020_03_27_012757 982 40 Cancer Cancer NNP 10_1101-2020_03_27_012757 982 41 cell cell NN 10_1101-2020_03_27_012757 982 42 lines line NNS 10_1101-2020_03_27_012757 982 43 ( ( -LRB- 10_1101-2020_03_27_012757 982 44 CCL CCL NNP 10_1101-2020_03_27_012757 982 45 ) ) -RRB- 10_1101-2020_03_27_012757 982 46 Patient Patient NNP 10_1101-2020_03_27_012757 982 47 derived derive VBN 10_1101-2020_03_27_012757 982 48 xenograft xenograft NN 10_1101-2020_03_27_012757 982 49 ( ( -LRB- 10_1101-2020_03_27_012757 982 50 PDX PDX NNP 10_1101-2020_03_27_012757 982 51 ) ) -RRB- 10_1101-2020_03_27_012757 982 52 Genetically genetically RB 10_1101-2020_03_27_012757 982 53 engineered engineer VBN 10_1101-2020_03_27_012757 982 54 mouse mouse NN 10_1101-2020_03_27_012757 982 55 model model NN 10_1101-2020_03_27_012757 982 56 ( ( -LRB- 10_1101-2020_03_27_012757 982 57 GEMM GEMM NNP 10_1101-2020_03_27_012757 982 58 ) ) -RRB- 10_1101-2020_03_27_012757 982 59 Tumoroids Tumoroids NNP 10_1101-2020_03_27_012757 982 60 Select Select NNP 10_1101-2020_03_27_012757 982 61 parameter parameter NN 10_1101-2020_03_27_012757 982 62 set set VBN 10_1101-2020_03_27_012757 982 63 with with IN 10_1101-2020_03_27_012757 982 64 maximum maximum JJ 10_1101-2020_03_27_012757 982 65 mean mean NN 10_1101-2020_03_27_012757 982 66 AUPRC AUPRC NNP 10_1101-2020_03_27_012757 982 67 . . . 10_1101-2020_03_27_012757 983 1 Train train VB 10_1101-2020_03_27_012757 983 2 on on IN 10_1101-2020_03_27_012757 983 3 all all DT 10_1101-2020_03_27_012757 983 4 TCGA TCGA NNP 10_1101-2020_03_27_012757 983 5 data datum NNS 10_1101-2020_03_27_012757 983 6 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 983 7 Set Set VBN 10_1101-2020_03_27_012757 983 8 parameters parameter NNS 10_1101-2020_03_27_012757 983 9 n n IN 10_1101-2020_03_27_012757 983 10 , , , 10_1101-2020_03_27_012757 983 11 m m NNP 10_1101-2020_03_27_012757 983 12 Randomly randomly RB 10_1101-2020_03_27_012757 983 13 select select VB 10_1101-2020_03_27_012757 983 14 2/3 2/3 CD 10_1101-2020_03_27_012757 983 15 TCGA tcga NN 10_1101-2020_03_27_012757 983 16 data datum NNS 10_1101-2020_03_27_012757 983 17 ; ; : 10_1101-2020_03_27_012757 983 18 run run VB 10_1101-2020_03_27_012757 983 19 training training NN 10_1101-2020_03_27_012757 983 20 process process NN 10_1101-2020_03_27_012757 983 21 Assess Assess NNP 10_1101-2020_03_27_012757 983 22 performance performance NN 10_1101-2020_03_27_012757 983 23 on on IN 10_1101-2020_03_27_012757 983 24 1/3 1/3 CD 10_1101-2020_03_27_012757 983 25 held hold VBN 10_1101-2020_03_27_012757 983 26 out out RP 10_1101-2020_03_27_012757 983 27 data datum NNS 10_1101-2020_03_27_012757 983 28 Repeat Repeat NNP 10_1101-2020_03_27_012757 983 29 steps step NNS 10_1101-2020_03_27_012757 983 30 ( ( -LRB- 10_1101-2020_03_27_012757 983 31 2 2 CD 10_1101-2020_03_27_012757 983 32 - - SYM 10_1101-2020_03_27_012757 983 33 3 3 CD 10_1101-2020_03_27_012757 983 34 ) ) -RRB- 10_1101-2020_03_27_012757 983 35 5 5 CD 10_1101-2020_03_27_012757 983 36 times time NNS 10_1101-2020_03_27_012757 983 37 ( ( -LRB- 10_1101-2020_03_27_012757 983 38 1 1 CD 10_1101-2020_03_27_012757 983 39 ) ) -RRB- 10_1101-2020_03_27_012757 983 40 ( ( -LRB- 10_1101-2020_03_27_012757 983 41 2 2 CD 10_1101-2020_03_27_012757 983 42 ) ) -RRB- 10_1101-2020_03_27_012757 983 43 ( ( -LRB- 10_1101-2020_03_27_012757 983 44 3 3 CD 10_1101-2020_03_27_012757 983 45 ) ) -RRB- 10_1101-2020_03_27_012757 983 46 ( ( -LRB- 10_1101-2020_03_27_012757 983 47 4 4 LS 10_1101-2020_03_27_012757 983 48 ) ) -RRB- 10_1101-2020_03_27_012757 983 49 Repeat Repeat NNP 10_1101-2020_03_27_012757 983 50 steps step NNS 10_1101-2020_03_27_012757 983 51 ( ( -LRB- 10_1101-2020_03_27_012757 983 52 1 1 CD 10_1101-2020_03_27_012757 983 53 - - SYM 10_1101-2020_03_27_012757 983 54 4 4 CD 10_1101-2020_03_27_012757 983 55 ) ) -RRB- 10_1101-2020_03_27_012757 983 56 for for IN 10_1101-2020_03_27_012757 983 57 each each DT 10_1101-2020_03_27_012757 983 58 parameter parameter NN 10_1101-2020_03_27_012757 983 59 set set NN 10_1101-2020_03_27_012757 983 60 ( ( -LRB- 10_1101-2020_03_27_012757 983 61 5 5 CD 10_1101-2020_03_27_012757 983 62 ) ) -RRB- 10_1101-2020_03_27_012757 983 63 CancerCellNet cancercellnet JJ 10_1101-2020_03_27_012757 983 64 RNA RNA NNP 10_1101-2020_03_27_012757 983 65 - - HYPH 10_1101-2020_03_27_012757 983 66 seq seq NN 10_1101-2020_03_27_012757 983 67 from from IN 10_1101-2020_03_27_012757 983 68 … … NFP 10_1101-2020_03_27_012757 983 69 G G NNP 10_1101-2020_03_27_012757 983 70 en en NNP 10_1101-2020_03_27_012757 983 71 e e NNP 10_1101-2020_03_27_012757 983 72 pa pa NNP 10_1101-2020_03_27_012757 983 73 irs irs NNP 10_1101-2020_03_27_012757 983 74 Training Training NNP 10_1101-2020_03_27_012757 983 75 data datum NNS 10_1101-2020_03_27_012757 983 76 Training Training NNP 10_1101-2020_03_27_012757 983 77 process process NN 10_1101-2020_03_27_012757 983 78 Train Train NNP 10_1101-2020_03_27_012757 983 79 Random Random NNP 10_1101-2020_03_27_012757 983 80 Forest Forest NNP 10_1101-2020_03_27_012757 983 81 classifier classifier NN 10_1101-2020_03_27_012757 983 82 G g NN 10_1101-2020_03_27_012757 983 83 en en FW 10_1101-2020_03_27_012757 983 84 es es FW 10_1101-2020_03_27_012757 983 85 Samples sample NNS 10_1101-2020_03_27_012757 983 86 G G NNP 10_1101-2020_03_27_012757 983 87 en en FW 10_1101-2020_03_27_012757 983 88 es es XX 10_1101-2020_03_27_012757 983 89 Labeled Labeled NNP 10_1101-2020_03_27_012757 983 90 RNA RNA NNP 10_1101-2020_03_27_012757 983 91 - - HYPH 10_1101-2020_03_27_012757 983 92 seq seq NN 10_1101-2020_03_27_012757 983 93 data datum NNS 10_1101-2020_03_27_012757 983 94 Select Select NNP 10_1101-2020_03_27_012757 983 95 n n DT 10_1101-2020_03_27_012757 983 96 genes gene NNS 10_1101-2020_03_27_012757 983 97 Gene gene NN 10_1101-2020_03_27_012757 983 98 pair pair NN 10_1101-2020_03_27_012757 983 99 transform transform NN 10_1101-2020_03_27_012757 983 100 Select Select NNP 10_1101-2020_03_27_012757 983 101 m m NNP 10_1101-2020_03_27_012757 983 102 gene gene NN 10_1101-2020_03_27_012757 983 103 pairs pairs NNP 10_1101-2020_03_27_012757 983 104 G G NNP 10_1101-2020_03_27_012757 983 105 en en NNP 10_1101-2020_03_27_012757 983 106 e e NNP 10_1101-2020_03_27_012757 983 107 pa pa NNP 10_1101-2020_03_27_012757 983 108 irs irs NNP 10_1101-2020_03_27_012757 983 109 G G NNP 10_1101-2020_03_27_012757 983 110 en en FW 10_1101-2020_03_27_012757 983 111 es es XX 10_1101-2020_03_27_012757 983 112 Samples Samples NNP 10_1101-2020_03_27_012757 983 113 Samples Samples NNP 10_1101-2020_03_27_012757 983 114 Samples Samples NNP 10_1101-2020_03_27_012757 983 115 Samples Samples NNP 10_1101-2020_03_27_012757 983 116 Samples Samples NNP 10_1101-2020_03_27_012757 983 117 CancerCellNet cancercellnet NN 10_1101-2020_03_27_012757 983 118 C c NN 10_1101-2020_03_27_012757 983 119 D d NN 10_1101-2020_03_27_012757 983 120 E e NN 10_1101-2020_03_27_012757 983 121 .CC .CC NFP 10_1101-2020_03_27_012757 983 122 - - HYPH 10_1101-2020_03_27_012757 983 123 BY by IN 10_1101-2020_03_27_012757 983 124 - - HYPH 10_1101-2020_03_27_012757 983 125 NC NC NNP 10_1101-2020_03_27_012757 983 126 - - HYPH 10_1101-2020_03_27_012757 983 127 ND ND NNP 10_1101-2020_03_27_012757 983 128 4.0 4.0 CD 10_1101-2020_03_27_012757 983 129 International International NNP 10_1101-2020_03_27_012757 983 130 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 983 131 under under IN 10_1101-2020_03_27_012757 983 132 a a DT 10_1101-2020_03_27_012757 983 133 ( ( -LRB- 10_1101-2020_03_27_012757 983 134 which which WDT 10_1101-2020_03_27_012757 983 135 was be VBD 10_1101-2020_03_27_012757 983 136 not not RB 10_1101-2020_03_27_012757 983 137 certified certify VBN 10_1101-2020_03_27_012757 983 138 by by IN 10_1101-2020_03_27_012757 983 139 peer peer NN 10_1101-2020_03_27_012757 983 140 review review NN 10_1101-2020_03_27_012757 983 141 ) ) -RRB- 10_1101-2020_03_27_012757 983 142 is be VBZ 10_1101-2020_03_27_012757 983 143 the the DT 10_1101-2020_03_27_012757 983 144 author author NN 10_1101-2020_03_27_012757 983 145 / / SYM 10_1101-2020_03_27_012757 983 146 funder funder NN 10_1101-2020_03_27_012757 983 147 , , , 10_1101-2020_03_27_012757 983 148 who who WP 10_1101-2020_03_27_012757 983 149 has have VBZ 10_1101-2020_03_27_012757 983 150 granted grant VBN 10_1101-2020_03_27_012757 983 151 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 983 152 a a DT 10_1101-2020_03_27_012757 983 153 license license NN 10_1101-2020_03_27_012757 983 154 to to TO 10_1101-2020_03_27_012757 983 155 display display VB 10_1101-2020_03_27_012757 983 156 the the DT 10_1101-2020_03_27_012757 983 157 preprint preprint NN 10_1101-2020_03_27_012757 983 158 in in IN 10_1101-2020_03_27_012757 983 159 perpetuity perpetuity NN 10_1101-2020_03_27_012757 983 160 . . . 10_1101-2020_03_27_012757 984 1 It -PRON- PRP 10_1101-2020_03_27_012757 984 2 is be VBZ 10_1101-2020_03_27_012757 984 3 made make VBN 10_1101-2020_03_27_012757 984 4 The the DT 10_1101-2020_03_27_012757 984 5 copyright copyright NN 10_1101-2020_03_27_012757 984 6 holder holder NN 10_1101-2020_03_27_012757 984 7 for for IN 10_1101-2020_03_27_012757 984 8 this this DT 10_1101-2020_03_27_012757 984 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 984 10 version version NN 10_1101-2020_03_27_012757 984 11 posted post VBD 10_1101-2020_03_27_012757 984 12 January January NNP 10_1101-2020_03_27_012757 984 13 9 9 CD 10_1101-2020_03_27_012757 984 14 , , , 10_1101-2020_03_27_012757 984 15 2021 2021 CD 10_1101-2020_03_27_012757 984 16 . . . 10_1101-2020_03_27_012757 984 17 ; ; : 10_1101-2020_03_27_012757 984 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 984 19 : : : 10_1101-2020_03_27_012757 984 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 984 21 preprint preprint NN 10_1101-2020_03_27_012757 984 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 984 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 984 24 Figure figure NN 10_1101-2020_03_27_012757 984 25 2 2 CD 10_1101-2020_03_27_012757 984 26 A A NNP 10_1101-2020_03_27_012757 984 27 F f NN 10_1101-2020_03_27_012757 984 28 C c NN 10_1101-2020_03_27_012757 984 29 D d NN 10_1101-2020_03_27_012757 984 30 E e NN 10_1101-2020_03_27_012757 984 31 CCN ccn NN 10_1101-2020_03_27_012757 984 32 Score score NN 10_1101-2020_03_27_012757 984 33 B b NN 10_1101-2020_03_27_012757 984 34 .CC .CC , 10_1101-2020_03_27_012757 984 35 - - : 10_1101-2020_03_27_012757 984 36 BY by IN 10_1101-2020_03_27_012757 984 37 - - HYPH 10_1101-2020_03_27_012757 984 38 NC NC NNP 10_1101-2020_03_27_012757 984 39 - - HYPH 10_1101-2020_03_27_012757 984 40 ND ND NNP 10_1101-2020_03_27_012757 984 41 4.0 4.0 CD 10_1101-2020_03_27_012757 984 42 International International NNP 10_1101-2020_03_27_012757 984 43 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 984 44 under under IN 10_1101-2020_03_27_012757 984 45 a a DT 10_1101-2020_03_27_012757 984 46 ( ( -LRB- 10_1101-2020_03_27_012757 984 47 which which WDT 10_1101-2020_03_27_012757 984 48 was be VBD 10_1101-2020_03_27_012757 984 49 not not RB 10_1101-2020_03_27_012757 984 50 certified certify VBN 10_1101-2020_03_27_012757 984 51 by by IN 10_1101-2020_03_27_012757 984 52 peer peer NN 10_1101-2020_03_27_012757 984 53 review review NN 10_1101-2020_03_27_012757 984 54 ) ) -RRB- 10_1101-2020_03_27_012757 984 55 is be VBZ 10_1101-2020_03_27_012757 984 56 the the DT 10_1101-2020_03_27_012757 984 57 author author NN 10_1101-2020_03_27_012757 984 58 / / SYM 10_1101-2020_03_27_012757 984 59 funder funder NN 10_1101-2020_03_27_012757 984 60 , , , 10_1101-2020_03_27_012757 984 61 who who WP 10_1101-2020_03_27_012757 984 62 has have VBZ 10_1101-2020_03_27_012757 984 63 granted grant VBN 10_1101-2020_03_27_012757 984 64 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 984 65 a a DT 10_1101-2020_03_27_012757 984 66 license license NN 10_1101-2020_03_27_012757 984 67 to to TO 10_1101-2020_03_27_012757 984 68 display display VB 10_1101-2020_03_27_012757 984 69 the the DT 10_1101-2020_03_27_012757 984 70 preprint preprint NN 10_1101-2020_03_27_012757 984 71 in in IN 10_1101-2020_03_27_012757 984 72 perpetuity perpetuity NN 10_1101-2020_03_27_012757 984 73 . . . 10_1101-2020_03_27_012757 985 1 It -PRON- PRP 10_1101-2020_03_27_012757 985 2 is be VBZ 10_1101-2020_03_27_012757 985 3 made make VBN 10_1101-2020_03_27_012757 985 4 The the DT 10_1101-2020_03_27_012757 985 5 copyright copyright NN 10_1101-2020_03_27_012757 985 6 holder holder NN 10_1101-2020_03_27_012757 985 7 for for IN 10_1101-2020_03_27_012757 985 8 this this DT 10_1101-2020_03_27_012757 985 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 985 10 version version NN 10_1101-2020_03_27_012757 985 11 posted post VBD 10_1101-2020_03_27_012757 985 12 January January NNP 10_1101-2020_03_27_012757 985 13 9 9 CD 10_1101-2020_03_27_012757 985 14 , , , 10_1101-2020_03_27_012757 985 15 2021 2021 CD 10_1101-2020_03_27_012757 985 16 . . . 10_1101-2020_03_27_012757 985 17 ; ; : 10_1101-2020_03_27_012757 985 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 985 19 : : : 10_1101-2020_03_27_012757 985 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 985 21 preprint preprint NN 10_1101-2020_03_27_012757 985 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 985 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 985 24 CCN CCN NNP 10_1101-2020_03_27_012757 985 25 Score Score NNP 10_1101-2020_03_27_012757 985 26 A a NN 10_1101-2020_03_27_012757 985 27 B b NN 10_1101-2020_03_27_012757 985 28 C c NN 10_1101-2020_03_27_012757 985 29 Figure figure NN 10_1101-2020_03_27_012757 985 30 3 3 CD 10_1101-2020_03_27_012757 985 31 .CC .CC : 10_1101-2020_03_27_012757 985 32 - - HYPH 10_1101-2020_03_27_012757 985 33 BY by IN 10_1101-2020_03_27_012757 985 34 - - HYPH 10_1101-2020_03_27_012757 985 35 NC NC NNP 10_1101-2020_03_27_012757 985 36 - - HYPH 10_1101-2020_03_27_012757 985 37 ND ND NNP 10_1101-2020_03_27_012757 985 38 4.0 4.0 CD 10_1101-2020_03_27_012757 985 39 International International NNP 10_1101-2020_03_27_012757 985 40 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 985 41 under under IN 10_1101-2020_03_27_012757 985 42 a a DT 10_1101-2020_03_27_012757 985 43 ( ( -LRB- 10_1101-2020_03_27_012757 985 44 which which WDT 10_1101-2020_03_27_012757 985 45 was be VBD 10_1101-2020_03_27_012757 985 46 not not RB 10_1101-2020_03_27_012757 985 47 certified certify VBN 10_1101-2020_03_27_012757 985 48 by by IN 10_1101-2020_03_27_012757 985 49 peer peer NN 10_1101-2020_03_27_012757 985 50 review review NN 10_1101-2020_03_27_012757 985 51 ) ) -RRB- 10_1101-2020_03_27_012757 985 52 is be VBZ 10_1101-2020_03_27_012757 985 53 the the DT 10_1101-2020_03_27_012757 985 54 author author NN 10_1101-2020_03_27_012757 985 55 / / SYM 10_1101-2020_03_27_012757 985 56 funder funder NN 10_1101-2020_03_27_012757 985 57 , , , 10_1101-2020_03_27_012757 985 58 who who WP 10_1101-2020_03_27_012757 985 59 has have VBZ 10_1101-2020_03_27_012757 985 60 granted grant VBN 10_1101-2020_03_27_012757 985 61 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 985 62 a a DT 10_1101-2020_03_27_012757 985 63 license license NN 10_1101-2020_03_27_012757 985 64 to to TO 10_1101-2020_03_27_012757 985 65 display display VB 10_1101-2020_03_27_012757 985 66 the the DT 10_1101-2020_03_27_012757 985 67 preprint preprint NN 10_1101-2020_03_27_012757 985 68 in in IN 10_1101-2020_03_27_012757 985 69 perpetuity perpetuity NN 10_1101-2020_03_27_012757 985 70 . . . 10_1101-2020_03_27_012757 986 1 It -PRON- PRP 10_1101-2020_03_27_012757 986 2 is be VBZ 10_1101-2020_03_27_012757 986 3 made make VBN 10_1101-2020_03_27_012757 986 4 The the DT 10_1101-2020_03_27_012757 986 5 copyright copyright NN 10_1101-2020_03_27_012757 986 6 holder holder NN 10_1101-2020_03_27_012757 986 7 for for IN 10_1101-2020_03_27_012757 986 8 this this DT 10_1101-2020_03_27_012757 986 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 986 10 version version NN 10_1101-2020_03_27_012757 986 11 posted post VBD 10_1101-2020_03_27_012757 986 12 January January NNP 10_1101-2020_03_27_012757 986 13 9 9 CD 10_1101-2020_03_27_012757 986 14 , , , 10_1101-2020_03_27_012757 986 15 2021 2021 CD 10_1101-2020_03_27_012757 986 16 . . . 10_1101-2020_03_27_012757 986 17 ; ; : 10_1101-2020_03_27_012757 986 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 986 19 : : : 10_1101-2020_03_27_012757 986 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 986 21 preprint preprint NN 10_1101-2020_03_27_012757 986 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 986 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 986 24 D d NN 10_1101-2020_03_27_012757 986 25 A A NNP 10_1101-2020_03_27_012757 986 26 B B NNP 10_1101-2020_03_27_012757 986 27 Figure figure NN 10_1101-2020_03_27_012757 986 28 4 4 CD 10_1101-2020_03_27_012757 986 29 C c NN 10_1101-2020_03_27_012757 986 30 General general JJ 10_1101-2020_03_27_012757 986 31 classification classification NN 10_1101-2020_03_27_012757 986 32 General General NNP 10_1101-2020_03_27_012757 986 33 CCN CCN NNP 10_1101-2020_03_27_012757 986 34 score score NN 10_1101-2020_03_27_012757 986 35 ( ( -LRB- 10_1101-2020_03_27_012757 986 36 UCEC UCEC NNP 10_1101-2020_03_27_012757 986 37 ) ) -RRB- 10_1101-2020_03_27_012757 986 38 Sub Sub NNP 10_1101-2020_03_27_012757 986 39 - - HYPH 10_1101-2020_03_27_012757 986 40 type type NN 10_1101-2020_03_27_012757 986 41 classification classification NN 10_1101-2020_03_27_012757 986 42 Endometrioid endometrioid NN 10_1101-2020_03_27_012757 986 43 Serous Serous NNP 10_1101-2020_03_27_012757 986 44 Normal Normal NNP 10_1101-2020_03_27_012757 986 45 Unknown unknown JJ 10_1101-2020_03_27_012757 986 46 General general JJ 10_1101-2020_03_27_012757 986 47 classification classification NN 10_1101-2020_03_27_012757 986 48 General General NNP 10_1101-2020_03_27_012757 986 49 CCN CCN NNP 10_1101-2020_03_27_012757 986 50 score score NN 10_1101-2020_03_27_012757 986 51 ( ( -LRB- 10_1101-2020_03_27_012757 986 52 LUSC LUSC NNP 10_1101-2020_03_27_012757 986 53 ) ) -RRB- 10_1101-2020_03_27_012757 986 54 Sub Sub NNP 10_1101-2020_03_27_012757 986 55 - - HYPH 10_1101-2020_03_27_012757 986 56 type type NN 10_1101-2020_03_27_012757 986 57 classification classification NN 10_1101-2020_03_27_012757 986 58 basal basal NN 10_1101-2020_03_27_012757 986 59 classical classical JJ 10_1101-2020_03_27_012757 986 60 primitive primitive JJ 10_1101-2020_03_27_012757 986 61 secretory secretory NN 10_1101-2020_03_27_012757 986 62 Unknown Unknown NNP 10_1101-2020_03_27_012757 986 63 General General NNP 10_1101-2020_03_27_012757 986 64 classification classification NN 10_1101-2020_03_27_012757 986 65 General General NNP 10_1101-2020_03_27_012757 986 66 CCN CCN NNP 10_1101-2020_03_27_012757 986 67 score score NN 10_1101-2020_03_27_012757 986 68 ( ( -LRB- 10_1101-2020_03_27_012757 986 69 LUAD luad RB 10_1101-2020_03_27_012757 986 70 ) ) -RRB- 10_1101-2020_03_27_012757 986 71 Sub Sub NNP 10_1101-2020_03_27_012757 986 72 - - HYPH 10_1101-2020_03_27_012757 986 73 type type NNP 10_1101-2020_03_27_012757 986 74 classification classification NN 10_1101-2020_03_27_012757 986 75 prox.-inflam prox.-inflam NN 10_1101-2020_03_27_012757 986 76 prox.-prolif prox.-prolif NNP 10_1101-2020_03_27_012757 986 77 TRU TRU NNP 10_1101-2020_03_27_012757 986 78 Unknown unknown JJ 10_1101-2020_03_27_012757 986 79 .CC .CC NFP 10_1101-2020_03_27_012757 986 80 - - HYPH 10_1101-2020_03_27_012757 986 81 BY by IN 10_1101-2020_03_27_012757 986 82 - - HYPH 10_1101-2020_03_27_012757 986 83 NC NC NNP 10_1101-2020_03_27_012757 986 84 - - HYPH 10_1101-2020_03_27_012757 986 85 ND ND NNP 10_1101-2020_03_27_012757 986 86 4.0 4.0 CD 10_1101-2020_03_27_012757 986 87 International International NNP 10_1101-2020_03_27_012757 986 88 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 986 89 under under IN 10_1101-2020_03_27_012757 986 90 a a DT 10_1101-2020_03_27_012757 986 91 ( ( -LRB- 10_1101-2020_03_27_012757 986 92 which which WDT 10_1101-2020_03_27_012757 986 93 was be VBD 10_1101-2020_03_27_012757 986 94 not not RB 10_1101-2020_03_27_012757 986 95 certified certify VBN 10_1101-2020_03_27_012757 986 96 by by IN 10_1101-2020_03_27_012757 986 97 peer peer NN 10_1101-2020_03_27_012757 986 98 review review NN 10_1101-2020_03_27_012757 986 99 ) ) -RRB- 10_1101-2020_03_27_012757 986 100 is be VBZ 10_1101-2020_03_27_012757 986 101 the the DT 10_1101-2020_03_27_012757 986 102 author author NN 10_1101-2020_03_27_012757 986 103 / / SYM 10_1101-2020_03_27_012757 986 104 funder funder NN 10_1101-2020_03_27_012757 986 105 , , , 10_1101-2020_03_27_012757 986 106 who who WP 10_1101-2020_03_27_012757 986 107 has have VBZ 10_1101-2020_03_27_012757 986 108 granted grant VBN 10_1101-2020_03_27_012757 986 109 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 986 110 a a DT 10_1101-2020_03_27_012757 986 111 license license NN 10_1101-2020_03_27_012757 986 112 to to TO 10_1101-2020_03_27_012757 986 113 display display VB 10_1101-2020_03_27_012757 986 114 the the DT 10_1101-2020_03_27_012757 986 115 preprint preprint NN 10_1101-2020_03_27_012757 986 116 in in IN 10_1101-2020_03_27_012757 986 117 perpetuity perpetuity NN 10_1101-2020_03_27_012757 986 118 . . . 10_1101-2020_03_27_012757 987 1 It -PRON- PRP 10_1101-2020_03_27_012757 987 2 is be VBZ 10_1101-2020_03_27_012757 987 3 made make VBN 10_1101-2020_03_27_012757 987 4 The the DT 10_1101-2020_03_27_012757 987 5 copyright copyright NN 10_1101-2020_03_27_012757 987 6 holder holder NN 10_1101-2020_03_27_012757 987 7 for for IN 10_1101-2020_03_27_012757 987 8 this this DT 10_1101-2020_03_27_012757 987 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 987 10 version version NN 10_1101-2020_03_27_012757 987 11 posted post VBD 10_1101-2020_03_27_012757 987 12 January January NNP 10_1101-2020_03_27_012757 987 13 9 9 CD 10_1101-2020_03_27_012757 987 14 , , , 10_1101-2020_03_27_012757 987 15 2021 2021 CD 10_1101-2020_03_27_012757 987 16 . . . 10_1101-2020_03_27_012757 987 17 ; ; : 10_1101-2020_03_27_012757 987 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 987 19 : : : 10_1101-2020_03_27_012757 987 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 987 21 preprint preprint NN 10_1101-2020_03_27_012757 987 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 987 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2020_03_27_012757 987 24 CCN CCN NNP 10_1101-2020_03_27_012757 987 25 Score Score NNP 10_1101-2020_03_27_012757 987 26 Figure figure NN 10_1101-2020_03_27_012757 987 27 5 5 CD 10_1101-2020_03_27_012757 987 28 A A NNP 10_1101-2020_03_27_012757 987 29 B b NN 10_1101-2020_03_27_012757 987 30 C c NN 10_1101-2020_03_27_012757 987 31 D d NN 10_1101-2020_03_27_012757 987 32 E e NN 10_1101-2020_03_27_012757 987 33 General general JJ 10_1101-2020_03_27_012757 987 34 classification classification NN 10_1101-2020_03_27_012757 987 35 General General NNP 10_1101-2020_03_27_012757 987 36 CCN CCN NNP 10_1101-2020_03_27_012757 987 37 score score NN 10_1101-2020_03_27_012757 987 38 ( ( -LRB- 10_1101-2020_03_27_012757 987 39 UCEC UCEC NNP 10_1101-2020_03_27_012757 987 40 ) ) -RRB- 10_1101-2020_03_27_012757 987 41 Sub Sub NNP 10_1101-2020_03_27_012757 987 42 - - HYPH 10_1101-2020_03_27_012757 987 43 type type NN 10_1101-2020_03_27_012757 987 44 classification classification NN 10_1101-2020_03_27_012757 987 45 Endometrioid endometrioid NN 10_1101-2020_03_27_012757 987 46 Serous Serous NNP 10_1101-2020_03_27_012757 987 47 Normal Normal NNP 10_1101-2020_03_27_012757 987 48 Unknown unknown JJ 10_1101-2020_03_27_012757 987 49 General general JJ 10_1101-2020_03_27_012757 987 50 classification classification NN 10_1101-2020_03_27_012757 987 51 General General NNP 10_1101-2020_03_27_012757 987 52 CCN CCN NNP 10_1101-2020_03_27_012757 987 53 score score NN 10_1101-2020_03_27_012757 987 54 ( ( -LRB- 10_1101-2020_03_27_012757 987 55 LUSC LUSC NNP 10_1101-2020_03_27_012757 987 56 ) ) -RRB- 10_1101-2020_03_27_012757 987 57 Sub Sub NNP 10_1101-2020_03_27_012757 987 58 - - HYPH 10_1101-2020_03_27_012757 987 59 type type NN 10_1101-2020_03_27_012757 987 60 classification classification NN 10_1101-2020_03_27_012757 987 61 basal basal NN 10_1101-2020_03_27_012757 987 62 classical classical JJ 10_1101-2020_03_27_012757 987 63 primitive primitive JJ 10_1101-2020_03_27_012757 987 64 secretory secretory NN 10_1101-2020_03_27_012757 987 65 Unknown Unknown NNP 10_1101-2020_03_27_012757 987 66 General General NNP 10_1101-2020_03_27_012757 987 67 classification classification NN 10_1101-2020_03_27_012757 987 68 General General NNP 10_1101-2020_03_27_012757 987 69 CCN CCN NNP 10_1101-2020_03_27_012757 987 70 score score NN 10_1101-2020_03_27_012757 987 71 ( ( -LRB- 10_1101-2020_03_27_012757 987 72 LUAD luad RB 10_1101-2020_03_27_012757 987 73 ) ) -RRB- 10_1101-2020_03_27_012757 987 74 Sub Sub NNP 10_1101-2020_03_27_012757 987 75 - - HYPH 10_1101-2020_03_27_012757 987 76 type type NNP 10_1101-2020_03_27_012757 987 77 classification classification NN 10_1101-2020_03_27_012757 987 78 prox.-inflam prox.-inflam NN 10_1101-2020_03_27_012757 987 79 prox.-prolif prox.-prolif NNP 10_1101-2020_03_27_012757 987 80 TRU TRU NNP 10_1101-2020_03_27_012757 987 81 Unknown unknown JJ 10_1101-2020_03_27_012757 987 82 .CC .CC NFP 10_1101-2020_03_27_012757 987 83 - - HYPH 10_1101-2020_03_27_012757 987 84 BY by IN 10_1101-2020_03_27_012757 987 85 - - HYPH 10_1101-2020_03_27_012757 987 86 NC NC NNP 10_1101-2020_03_27_012757 987 87 - - HYPH 10_1101-2020_03_27_012757 987 88 ND ND NNP 10_1101-2020_03_27_012757 987 89 4.0 4.0 CD 10_1101-2020_03_27_012757 987 90 International International NNP 10_1101-2020_03_27_012757 987 91 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 987 92 under under IN 10_1101-2020_03_27_012757 987 93 a a DT 10_1101-2020_03_27_012757 987 94 ( ( -LRB- 10_1101-2020_03_27_012757 987 95 which which WDT 10_1101-2020_03_27_012757 987 96 was be VBD 10_1101-2020_03_27_012757 987 97 not not RB 10_1101-2020_03_27_012757 987 98 certified certify VBN 10_1101-2020_03_27_012757 987 99 by by IN 10_1101-2020_03_27_012757 987 100 peer peer NN 10_1101-2020_03_27_012757 987 101 review review NN 10_1101-2020_03_27_012757 987 102 ) ) -RRB- 10_1101-2020_03_27_012757 987 103 is be VBZ 10_1101-2020_03_27_012757 987 104 the the DT 10_1101-2020_03_27_012757 987 105 author author NN 10_1101-2020_03_27_012757 987 106 / / SYM 10_1101-2020_03_27_012757 987 107 funder funder NN 10_1101-2020_03_27_012757 987 108 , , , 10_1101-2020_03_27_012757 987 109 who who WP 10_1101-2020_03_27_012757 987 110 has have VBZ 10_1101-2020_03_27_012757 987 111 granted grant VBN 10_1101-2020_03_27_012757 987 112 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 987 113 a a DT 10_1101-2020_03_27_012757 987 114 license license NN 10_1101-2020_03_27_012757 987 115 to to TO 10_1101-2020_03_27_012757 987 116 display display VB 10_1101-2020_03_27_012757 987 117 the the DT 10_1101-2020_03_27_012757 987 118 preprint preprint NN 10_1101-2020_03_27_012757 987 119 in in IN 10_1101-2020_03_27_012757 987 120 perpetuity perpetuity NN 10_1101-2020_03_27_012757 987 121 . . . 10_1101-2020_03_27_012757 988 1 It -PRON- PRP 10_1101-2020_03_27_012757 988 2 is be VBZ 10_1101-2020_03_27_012757 988 3 made make VBN 10_1101-2020_03_27_012757 988 4 The the DT 10_1101-2020_03_27_012757 988 5 copyright copyright NN 10_1101-2020_03_27_012757 988 6 holder holder NN 10_1101-2020_03_27_012757 988 7 for for IN 10_1101-2020_03_27_012757 988 8 this this DT 10_1101-2020_03_27_012757 988 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 988 10 version version NN 10_1101-2020_03_27_012757 988 11 posted post VBD 10_1101-2020_03_27_012757 988 12 January January NNP 10_1101-2020_03_27_012757 988 13 9 9 CD 10_1101-2020_03_27_012757 988 14 , , , 10_1101-2020_03_27_012757 988 15 2021 2021 CD 10_1101-2020_03_27_012757 988 16 . . . 10_1101-2020_03_27_012757 988 17 ; ; : 10_1101-2020_03_27_012757 988 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 988 19 : : : 10_1101-2020_03_27_012757 988 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 988 21 preprint preprint NN 10_1101-2020_03_27_012757 988 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 988 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 988 24 Figure figure NN 10_1101-2020_03_27_012757 988 25 6 6 CD 10_1101-2020_03_27_012757 988 26 C c NN 10_1101-2020_03_27_012757 988 27 BA ba NN 10_1101-2020_03_27_012757 988 28 D d NN 10_1101-2020_03_27_012757 988 29 E e NN 10_1101-2020_03_27_012757 988 30 General general JJ 10_1101-2020_03_27_012757 988 31 classification classification NN 10_1101-2020_03_27_012757 988 32 General General NNP 10_1101-2020_03_27_012757 988 33 CCN CCN NNP 10_1101-2020_03_27_012757 988 34 score score NN 10_1101-2020_03_27_012757 988 35 ( ( -LRB- 10_1101-2020_03_27_012757 988 36 UCEC UCEC NNP 10_1101-2020_03_27_012757 988 37 ) ) -RRB- 10_1101-2020_03_27_012757 988 38 Sub Sub NNP 10_1101-2020_03_27_012757 988 39 - - HYPH 10_1101-2020_03_27_012757 988 40 type type NN 10_1101-2020_03_27_012757 988 41 classification classification NN 10_1101-2020_03_27_012757 988 42 Genotype Genotype NNP 10_1101-2020_03_27_012757 988 43 Endometrioid Endometrioid NNP 10_1101-2020_03_27_012757 988 44 Serous Serous NNP 10_1101-2020_03_27_012757 988 45 Normal Normal NNP 10_1101-2020_03_27_012757 988 46 Unknown unknown JJ 10_1101-2020_03_27_012757 988 47 General general JJ 10_1101-2020_03_27_012757 988 48 classification classification NN 10_1101-2020_03_27_012757 988 49 General General NNP 10_1101-2020_03_27_012757 988 50 CCN CCN NNP 10_1101-2020_03_27_012757 988 51 score score NN 10_1101-2020_03_27_012757 988 52 ( ( -LRB- 10_1101-2020_03_27_012757 988 53 LUSC LUSC NNP 10_1101-2020_03_27_012757 988 54 ) ) -RRB- 10_1101-2020_03_27_012757 988 55 Sub Sub NNP 10_1101-2020_03_27_012757 988 56 - - HYPH 10_1101-2020_03_27_012757 988 57 type type NN 10_1101-2020_03_27_012757 988 58 classification classification NN 10_1101-2020_03_27_012757 988 59 Genotype Genotype NNP 10_1101-2020_03_27_012757 988 60 basal basal NN 10_1101-2020_03_27_012757 988 61 classical classical JJ 10_1101-2020_03_27_012757 988 62 primitive primitive JJ 10_1101-2020_03_27_012757 988 63 secretory secretory NN 10_1101-2020_03_27_012757 988 64 Unknown Unknown NNP 10_1101-2020_03_27_012757 988 65 General General NNP 10_1101-2020_03_27_012757 988 66 classification classification NN 10_1101-2020_03_27_012757 988 67 General General NNP 10_1101-2020_03_27_012757 988 68 CCN CCN NNP 10_1101-2020_03_27_012757 988 69 score score NN 10_1101-2020_03_27_012757 988 70 ( ( -LRB- 10_1101-2020_03_27_012757 988 71 LUAD luad RB 10_1101-2020_03_27_012757 988 72 ) ) -RRB- 10_1101-2020_03_27_012757 988 73 Sub Sub NNP 10_1101-2020_03_27_012757 988 74 - - HYPH 10_1101-2020_03_27_012757 988 75 type type NN 10_1101-2020_03_27_012757 988 76 classification classification NN 10_1101-2020_03_27_012757 988 77 Genotype Genotype NNP 10_1101-2020_03_27_012757 988 78 prox.-inflam prox.-inflam NNP 10_1101-2020_03_27_012757 988 79 prox.-prolif prox.-prolif NNP 10_1101-2020_03_27_012757 988 80 TRU TRU NNP 10_1101-2020_03_27_012757 988 81 Unknown unknown JJ 10_1101-2020_03_27_012757 988 82 CCN CCN NNP 10_1101-2020_03_27_012757 988 83 Score score NN 10_1101-2020_03_27_012757 988 84 .CC .cc NN 10_1101-2020_03_27_012757 988 85 - - : 10_1101-2020_03_27_012757 988 86 BY by IN 10_1101-2020_03_27_012757 988 87 - - HYPH 10_1101-2020_03_27_012757 988 88 NC NC NNP 10_1101-2020_03_27_012757 988 89 - - HYPH 10_1101-2020_03_27_012757 988 90 ND ND NNP 10_1101-2020_03_27_012757 988 91 4.0 4.0 CD 10_1101-2020_03_27_012757 988 92 International International NNP 10_1101-2020_03_27_012757 988 93 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 988 94 under under IN 10_1101-2020_03_27_012757 988 95 a a DT 10_1101-2020_03_27_012757 988 96 ( ( -LRB- 10_1101-2020_03_27_012757 988 97 which which WDT 10_1101-2020_03_27_012757 988 98 was be VBD 10_1101-2020_03_27_012757 988 99 not not RB 10_1101-2020_03_27_012757 988 100 certified certify VBN 10_1101-2020_03_27_012757 988 101 by by IN 10_1101-2020_03_27_012757 988 102 peer peer NN 10_1101-2020_03_27_012757 988 103 review review NN 10_1101-2020_03_27_012757 988 104 ) ) -RRB- 10_1101-2020_03_27_012757 988 105 is be VBZ 10_1101-2020_03_27_012757 988 106 the the DT 10_1101-2020_03_27_012757 988 107 author author NN 10_1101-2020_03_27_012757 988 108 / / SYM 10_1101-2020_03_27_012757 988 109 funder funder NN 10_1101-2020_03_27_012757 988 110 , , , 10_1101-2020_03_27_012757 988 111 who who WP 10_1101-2020_03_27_012757 988 112 has have VBZ 10_1101-2020_03_27_012757 988 113 granted grant VBN 10_1101-2020_03_27_012757 988 114 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 988 115 a a DT 10_1101-2020_03_27_012757 988 116 license license NN 10_1101-2020_03_27_012757 988 117 to to TO 10_1101-2020_03_27_012757 988 118 display display VB 10_1101-2020_03_27_012757 988 119 the the DT 10_1101-2020_03_27_012757 988 120 preprint preprint NN 10_1101-2020_03_27_012757 988 121 in in IN 10_1101-2020_03_27_012757 988 122 perpetuity perpetuity NN 10_1101-2020_03_27_012757 988 123 . . . 10_1101-2020_03_27_012757 989 1 It -PRON- PRP 10_1101-2020_03_27_012757 989 2 is be VBZ 10_1101-2020_03_27_012757 989 3 made make VBN 10_1101-2020_03_27_012757 989 4 The the DT 10_1101-2020_03_27_012757 989 5 copyright copyright NN 10_1101-2020_03_27_012757 989 6 holder holder NN 10_1101-2020_03_27_012757 989 7 for for IN 10_1101-2020_03_27_012757 989 8 this this DT 10_1101-2020_03_27_012757 989 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 989 10 version version NN 10_1101-2020_03_27_012757 989 11 posted post VBD 10_1101-2020_03_27_012757 989 12 January January NNP 10_1101-2020_03_27_012757 989 13 9 9 CD 10_1101-2020_03_27_012757 989 14 , , , 10_1101-2020_03_27_012757 989 15 2021 2021 CD 10_1101-2020_03_27_012757 989 16 . . . 10_1101-2020_03_27_012757 989 17 ; ; : 10_1101-2020_03_27_012757 989 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 989 19 : : : 10_1101-2020_03_27_012757 989 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 989 21 preprint preprint NN 10_1101-2020_03_27_012757 989 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 989 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 989 24 Figure figure NN 10_1101-2020_03_27_012757 989 25 7 7 CD 10_1101-2020_03_27_012757 989 26 A A NNP 10_1101-2020_03_27_012757 989 27 B b NN 10_1101-2020_03_27_012757 989 28 C c NN 10_1101-2020_03_27_012757 989 29 D d NN 10_1101-2020_03_27_012757 989 30 E e NN 10_1101-2020_03_27_012757 989 31 General general JJ 10_1101-2020_03_27_012757 989 32 classification classification NN 10_1101-2020_03_27_012757 989 33 General General NNP 10_1101-2020_03_27_012757 989 34 CCN CCN NNP 10_1101-2020_03_27_012757 989 35 score score NN 10_1101-2020_03_27_012757 989 36 ( ( -LRB- 10_1101-2020_03_27_012757 989 37 UCEC UCEC NNP 10_1101-2020_03_27_012757 989 38 ) ) -RRB- 10_1101-2020_03_27_012757 989 39 Sub Sub NNP 10_1101-2020_03_27_012757 989 40 - - HYPH 10_1101-2020_03_27_012757 989 41 type type NN 10_1101-2020_03_27_012757 989 42 classification classification NN 10_1101-2020_03_27_012757 989 43 Endometrioid endometrioid NN 10_1101-2020_03_27_012757 989 44 Serous Serous NNP 10_1101-2020_03_27_012757 989 45 Normal Normal NNP 10_1101-2020_03_27_012757 989 46 Unknown unknown JJ 10_1101-2020_03_27_012757 989 47 General general JJ 10_1101-2020_03_27_012757 989 48 classification classification NN 10_1101-2020_03_27_012757 989 49 General General NNP 10_1101-2020_03_27_012757 989 50 CCN CCN NNP 10_1101-2020_03_27_012757 989 51 score score NN 10_1101-2020_03_27_012757 989 52 ( ( -LRB- 10_1101-2020_03_27_012757 989 53 LUSC LUSC NNP 10_1101-2020_03_27_012757 989 54 ) ) -RRB- 10_1101-2020_03_27_012757 989 55 Sub Sub NNP 10_1101-2020_03_27_012757 989 56 - - HYPH 10_1101-2020_03_27_012757 989 57 type type NN 10_1101-2020_03_27_012757 989 58 classification classification NN 10_1101-2020_03_27_012757 989 59 basal basal NN 10_1101-2020_03_27_012757 989 60 classical classical JJ 10_1101-2020_03_27_012757 989 61 primitive primitive JJ 10_1101-2020_03_27_012757 989 62 secretory secretory NN 10_1101-2020_03_27_012757 989 63 Unknown Unknown NNP 10_1101-2020_03_27_012757 989 64 General General NNP 10_1101-2020_03_27_012757 989 65 classification classification NN 10_1101-2020_03_27_012757 989 66 General General NNP 10_1101-2020_03_27_012757 989 67 CCN CCN NNP 10_1101-2020_03_27_012757 989 68 score score NN 10_1101-2020_03_27_012757 989 69 ( ( -LRB- 10_1101-2020_03_27_012757 989 70 LUAD luad RB 10_1101-2020_03_27_012757 989 71 ) ) -RRB- 10_1101-2020_03_27_012757 989 72 Sub Sub NNP 10_1101-2020_03_27_012757 989 73 - - HYPH 10_1101-2020_03_27_012757 989 74 type type NNP 10_1101-2020_03_27_012757 989 75 classification classification NN 10_1101-2020_03_27_012757 989 76 prox.-inflam prox.-inflam NN 10_1101-2020_03_27_012757 989 77 prox.-prolif prox.-prolif NNP 10_1101-2020_03_27_012757 989 78 TRU TRU NNP 10_1101-2020_03_27_012757 989 79 Unknown unknown JJ 10_1101-2020_03_27_012757 989 80 CCN CCN NNP 10_1101-2020_03_27_012757 989 81 Score score NN 10_1101-2020_03_27_012757 989 82 .CC .cc NN 10_1101-2020_03_27_012757 989 83 - - : 10_1101-2020_03_27_012757 989 84 BY by IN 10_1101-2020_03_27_012757 989 85 - - HYPH 10_1101-2020_03_27_012757 989 86 NC NC NNP 10_1101-2020_03_27_012757 989 87 - - HYPH 10_1101-2020_03_27_012757 989 88 ND ND NNP 10_1101-2020_03_27_012757 989 89 4.0 4.0 CD 10_1101-2020_03_27_012757 989 90 International International NNP 10_1101-2020_03_27_012757 989 91 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 989 92 under under IN 10_1101-2020_03_27_012757 989 93 a a DT 10_1101-2020_03_27_012757 989 94 ( ( -LRB- 10_1101-2020_03_27_012757 989 95 which which WDT 10_1101-2020_03_27_012757 989 96 was be VBD 10_1101-2020_03_27_012757 989 97 not not RB 10_1101-2020_03_27_012757 989 98 certified certify VBN 10_1101-2020_03_27_012757 989 99 by by IN 10_1101-2020_03_27_012757 989 100 peer peer NN 10_1101-2020_03_27_012757 989 101 review review NN 10_1101-2020_03_27_012757 989 102 ) ) -RRB- 10_1101-2020_03_27_012757 989 103 is be VBZ 10_1101-2020_03_27_012757 989 104 the the DT 10_1101-2020_03_27_012757 989 105 author author NN 10_1101-2020_03_27_012757 989 106 / / SYM 10_1101-2020_03_27_012757 989 107 funder funder NN 10_1101-2020_03_27_012757 989 108 , , , 10_1101-2020_03_27_012757 989 109 who who WP 10_1101-2020_03_27_012757 989 110 has have VBZ 10_1101-2020_03_27_012757 989 111 granted grant VBN 10_1101-2020_03_27_012757 989 112 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 989 113 a a DT 10_1101-2020_03_27_012757 989 114 license license NN 10_1101-2020_03_27_012757 989 115 to to TO 10_1101-2020_03_27_012757 989 116 display display VB 10_1101-2020_03_27_012757 989 117 the the DT 10_1101-2020_03_27_012757 989 118 preprint preprint NN 10_1101-2020_03_27_012757 989 119 in in IN 10_1101-2020_03_27_012757 989 120 perpetuity perpetuity NN 10_1101-2020_03_27_012757 989 121 . . . 10_1101-2020_03_27_012757 990 1 It -PRON- PRP 10_1101-2020_03_27_012757 990 2 is be VBZ 10_1101-2020_03_27_012757 990 3 made make VBN 10_1101-2020_03_27_012757 990 4 The the DT 10_1101-2020_03_27_012757 990 5 copyright copyright NN 10_1101-2020_03_27_012757 990 6 holder holder NN 10_1101-2020_03_27_012757 990 7 for for IN 10_1101-2020_03_27_012757 990 8 this this DT 10_1101-2020_03_27_012757 990 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 990 10 version version NN 10_1101-2020_03_27_012757 990 11 posted post VBD 10_1101-2020_03_27_012757 990 12 January January NNP 10_1101-2020_03_27_012757 990 13 9 9 CD 10_1101-2020_03_27_012757 990 14 , , , 10_1101-2020_03_27_012757 990 15 2021 2021 CD 10_1101-2020_03_27_012757 990 16 . . . 10_1101-2020_03_27_012757 990 17 ; ; : 10_1101-2020_03_27_012757 990 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 990 19 : : : 10_1101-2020_03_27_012757 990 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 990 21 preprint preprint NN 10_1101-2020_03_27_012757 990 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 990 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 990 24 Figure figure NN 10_1101-2020_03_27_012757 990 25 8 8 CD 10_1101-2020_03_27_012757 990 26 .CC .CC : 10_1101-2020_03_27_012757 990 27 - - HYPH 10_1101-2020_03_27_012757 990 28 BY by IN 10_1101-2020_03_27_012757 990 29 - - HYPH 10_1101-2020_03_27_012757 990 30 NC NC NNP 10_1101-2020_03_27_012757 990 31 - - HYPH 10_1101-2020_03_27_012757 990 32 ND ND NNP 10_1101-2020_03_27_012757 990 33 4.0 4.0 CD 10_1101-2020_03_27_012757 990 34 International International NNP 10_1101-2020_03_27_012757 990 35 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 990 36 under under IN 10_1101-2020_03_27_012757 990 37 a a DT 10_1101-2020_03_27_012757 990 38 ( ( -LRB- 10_1101-2020_03_27_012757 990 39 which which WDT 10_1101-2020_03_27_012757 990 40 was be VBD 10_1101-2020_03_27_012757 990 41 not not RB 10_1101-2020_03_27_012757 990 42 certified certify VBN 10_1101-2020_03_27_012757 990 43 by by IN 10_1101-2020_03_27_012757 990 44 peer peer NN 10_1101-2020_03_27_012757 990 45 review review NN 10_1101-2020_03_27_012757 990 46 ) ) -RRB- 10_1101-2020_03_27_012757 990 47 is be VBZ 10_1101-2020_03_27_012757 990 48 the the DT 10_1101-2020_03_27_012757 990 49 author author NN 10_1101-2020_03_27_012757 990 50 / / SYM 10_1101-2020_03_27_012757 990 51 funder funder NN 10_1101-2020_03_27_012757 990 52 , , , 10_1101-2020_03_27_012757 990 53 who who WP 10_1101-2020_03_27_012757 990 54 has have VBZ 10_1101-2020_03_27_012757 990 55 granted grant VBN 10_1101-2020_03_27_012757 990 56 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 990 57 a a DT 10_1101-2020_03_27_012757 990 58 license license NN 10_1101-2020_03_27_012757 990 59 to to TO 10_1101-2020_03_27_012757 990 60 display display VB 10_1101-2020_03_27_012757 990 61 the the DT 10_1101-2020_03_27_012757 990 62 preprint preprint NN 10_1101-2020_03_27_012757 990 63 in in IN 10_1101-2020_03_27_012757 990 64 perpetuity perpetuity NN 10_1101-2020_03_27_012757 990 65 . . . 10_1101-2020_03_27_012757 991 1 It -PRON- PRP 10_1101-2020_03_27_012757 991 2 is be VBZ 10_1101-2020_03_27_012757 991 3 made make VBN 10_1101-2020_03_27_012757 991 4 The the DT 10_1101-2020_03_27_012757 991 5 copyright copyright NN 10_1101-2020_03_27_012757 991 6 holder holder NN 10_1101-2020_03_27_012757 991 7 for for IN 10_1101-2020_03_27_012757 991 8 this this DT 10_1101-2020_03_27_012757 991 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 991 10 version version NN 10_1101-2020_03_27_012757 991 11 posted post VBD 10_1101-2020_03_27_012757 991 12 January January NNP 10_1101-2020_03_27_012757 991 13 9 9 CD 10_1101-2020_03_27_012757 991 14 , , , 10_1101-2020_03_27_012757 991 15 2021 2021 CD 10_1101-2020_03_27_012757 991 16 . . . 10_1101-2020_03_27_012757 991 17 ; ; : 10_1101-2020_03_27_012757 991 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 991 19 : : : 10_1101-2020_03_27_012757 991 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 991 21 preprint preprint NN 10_1101-2020_03_27_012757 991 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 991 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 991 24 Supplemental Supplemental NNP 10_1101-2020_03_27_012757 991 25 Figure Figure NNP 10_1101-2020_03_27_012757 991 26 1 1 CD 10_1101-2020_03_27_012757 991 27 BA ba NN 10_1101-2020_03_27_012757 991 28 D d NN 10_1101-2020_03_27_012757 991 29 E E NNP 10_1101-2020_03_27_012757 991 30 Training Training NNP 10_1101-2020_03_27_012757 991 31 data datum NNS 10_1101-2020_03_27_012757 991 32 Samples Samples NNPS 10_1101-2020_03_27_012757 991 33 G g NN 10_1101-2020_03_27_012757 991 34 en en FW 10_1101-2020_03_27_012757 991 35 es es FW 10_1101-2020_03_27_012757 991 36 RNA RNA NNP 10_1101-2020_03_27_012757 991 37 - - HYPH 10_1101-2020_03_27_012757 991 38 Seq seq VB 10_1101-2020_03_27_012757 991 39 TCGA tcga NN 10_1101-2020_03_27_012757 991 40 Training Training NNP 10_1101-2020_03_27_012757 991 41 process process NN 10_1101-2020_03_27_012757 991 42 Gene Gene NNP 10_1101-2020_03_27_012757 991 43 Pair Pair NNP 10_1101-2020_03_27_012757 991 44 Transform Transform NNP 10_1101-2020_03_27_012757 991 45 Feature feature NN 10_1101-2020_03_27_012757 991 46 Selection selection NN 10_1101-2020_03_27_012757 991 47 Train train NN 10_1101-2020_03_27_012757 991 48 Random random JJ 10_1101-2020_03_27_012757 991 49 forest forest NN 10_1101-2020_03_27_012757 991 50 classifier classifier NN 10_1101-2020_03_27_012757 991 51 G g NN 10_1101-2020_03_27_012757 991 52 en en FW 10_1101-2020_03_27_012757 991 53 es es XX 10_1101-2020_03_27_012757 991 54 G g NN 10_1101-2020_03_27_012757 991 55 en en NN 10_1101-2020_03_27_012757 991 56 e e NNP 10_1101-2020_03_27_012757 991 57 P p NN 10_1101-2020_03_27_012757 991 58 ai ai VBP 10_1101-2020_03_27_012757 991 59 rs rs NN 10_1101-2020_03_27_012757 991 60 CancerCellNetBroad cancercellnetbroad CD 10_1101-2020_03_27_012757 991 61 Class class NN 10_1101-2020_03_27_012757 991 62 Classification Classification NNP 10_1101-2020_03_27_012757 991 63 Add Add NNP 10_1101-2020_03_27_012757 991 64 on on IN 10_1101-2020_03_27_012757 991 65 to to IN 10_1101-2020_03_27_012757 991 66 Gene Gene NNP 10_1101-2020_03_27_012757 991 67 Pairs Pairs NNP 10_1101-2020_03_27_012757 991 68 as as IN 10_1101-2020_03_27_012757 991 69 Additional Additional NNP 10_1101-2020_03_27_012757 991 70 Features Features NNP 10_1101-2020_03_27_012757 991 71 C C NNP 10_1101-2020_03_27_012757 991 72 C C NNP 10_1101-2020_03_27_012757 991 73 N N NNP 10_1101-2020_03_27_012757 991 74 S S NNP 10_1101-2020_03_27_012757 991 75 co co NN 10_1101-2020_03_27_012757 991 76 re re NN 10_1101-2020_03_27_012757 991 77 s s PRP 10_1101-2020_03_27_012757 991 78 G g NN 10_1101-2020_03_27_012757 991 79 en en NN 10_1101-2020_03_27_012757 991 80 e e NN 10_1101-2020_03_27_012757 991 81 P p NN 10_1101-2020_03_27_012757 991 82 ai ai VBP 10_1101-2020_03_27_012757 991 83 rs rs NN 10_1101-2020_03_27_012757 991 84 C c NN 10_1101-2020_03_27_012757 991 85 .CC .CC , 10_1101-2020_03_27_012757 991 86 - - : 10_1101-2020_03_27_012757 991 87 BY by IN 10_1101-2020_03_27_012757 991 88 - - HYPH 10_1101-2020_03_27_012757 991 89 NC NC NNP 10_1101-2020_03_27_012757 991 90 - - HYPH 10_1101-2020_03_27_012757 991 91 ND ND NNP 10_1101-2020_03_27_012757 991 92 4.0 4.0 CD 10_1101-2020_03_27_012757 991 93 International International NNP 10_1101-2020_03_27_012757 991 94 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 991 95 under under IN 10_1101-2020_03_27_012757 991 96 a a DT 10_1101-2020_03_27_012757 991 97 ( ( -LRB- 10_1101-2020_03_27_012757 991 98 which which WDT 10_1101-2020_03_27_012757 991 99 was be VBD 10_1101-2020_03_27_012757 991 100 not not RB 10_1101-2020_03_27_012757 991 101 certified certify VBN 10_1101-2020_03_27_012757 991 102 by by IN 10_1101-2020_03_27_012757 991 103 peer peer NN 10_1101-2020_03_27_012757 991 104 review review NN 10_1101-2020_03_27_012757 991 105 ) ) -RRB- 10_1101-2020_03_27_012757 991 106 is be VBZ 10_1101-2020_03_27_012757 991 107 the the DT 10_1101-2020_03_27_012757 991 108 author author NN 10_1101-2020_03_27_012757 991 109 / / SYM 10_1101-2020_03_27_012757 991 110 funder funder NN 10_1101-2020_03_27_012757 991 111 , , , 10_1101-2020_03_27_012757 991 112 who who WP 10_1101-2020_03_27_012757 991 113 has have VBZ 10_1101-2020_03_27_012757 991 114 granted grant VBN 10_1101-2020_03_27_012757 991 115 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 991 116 a a DT 10_1101-2020_03_27_012757 991 117 license license NN 10_1101-2020_03_27_012757 991 118 to to TO 10_1101-2020_03_27_012757 991 119 display display VB 10_1101-2020_03_27_012757 991 120 the the DT 10_1101-2020_03_27_012757 991 121 preprint preprint NN 10_1101-2020_03_27_012757 991 122 in in IN 10_1101-2020_03_27_012757 991 123 perpetuity perpetuity NN 10_1101-2020_03_27_012757 991 124 . . . 10_1101-2020_03_27_012757 992 1 It -PRON- PRP 10_1101-2020_03_27_012757 992 2 is be VBZ 10_1101-2020_03_27_012757 992 3 made make VBN 10_1101-2020_03_27_012757 992 4 The the DT 10_1101-2020_03_27_012757 992 5 copyright copyright NN 10_1101-2020_03_27_012757 992 6 holder holder NN 10_1101-2020_03_27_012757 992 7 for for IN 10_1101-2020_03_27_012757 992 8 this this DT 10_1101-2020_03_27_012757 992 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 992 10 version version NN 10_1101-2020_03_27_012757 992 11 posted post VBD 10_1101-2020_03_27_012757 992 12 January January NNP 10_1101-2020_03_27_012757 992 13 9 9 CD 10_1101-2020_03_27_012757 992 14 , , , 10_1101-2020_03_27_012757 992 15 2021 2021 CD 10_1101-2020_03_27_012757 992 16 . . . 10_1101-2020_03_27_012757 992 17 ; ; : 10_1101-2020_03_27_012757 992 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 992 19 : : : 10_1101-2020_03_27_012757 992 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 992 21 preprint preprint NN 10_1101-2020_03_27_012757 992 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 992 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 992 24 Supplemental Supplemental NNP 10_1101-2020_03_27_012757 992 25 Figure Figure NNP 10_1101-2020_03_27_012757 992 26 2 2 CD 10_1101-2020_03_27_012757 992 27 A a NN 10_1101-2020_03_27_012757 992 28 B b NN 10_1101-2020_03_27_012757 992 29 D d NN 10_1101-2020_03_27_012757 992 30 E e NN 10_1101-2020_03_27_012757 992 31 C c NN 10_1101-2020_03_27_012757 992 32 .CC .CC , 10_1101-2020_03_27_012757 992 33 - - : 10_1101-2020_03_27_012757 992 34 BY by IN 10_1101-2020_03_27_012757 992 35 - - HYPH 10_1101-2020_03_27_012757 992 36 NC NC NNP 10_1101-2020_03_27_012757 992 37 - - HYPH 10_1101-2020_03_27_012757 992 38 ND ND NNP 10_1101-2020_03_27_012757 992 39 4.0 4.0 CD 10_1101-2020_03_27_012757 992 40 International International NNP 10_1101-2020_03_27_012757 992 41 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 992 42 under under IN 10_1101-2020_03_27_012757 992 43 a a DT 10_1101-2020_03_27_012757 992 44 ( ( -LRB- 10_1101-2020_03_27_012757 992 45 which which WDT 10_1101-2020_03_27_012757 992 46 was be VBD 10_1101-2020_03_27_012757 992 47 not not RB 10_1101-2020_03_27_012757 992 48 certified certify VBN 10_1101-2020_03_27_012757 992 49 by by IN 10_1101-2020_03_27_012757 992 50 peer peer NN 10_1101-2020_03_27_012757 992 51 review review NN 10_1101-2020_03_27_012757 992 52 ) ) -RRB- 10_1101-2020_03_27_012757 992 53 is be VBZ 10_1101-2020_03_27_012757 992 54 the the DT 10_1101-2020_03_27_012757 992 55 author author NN 10_1101-2020_03_27_012757 992 56 / / SYM 10_1101-2020_03_27_012757 992 57 funder funder NN 10_1101-2020_03_27_012757 992 58 , , , 10_1101-2020_03_27_012757 992 59 who who WP 10_1101-2020_03_27_012757 992 60 has have VBZ 10_1101-2020_03_27_012757 992 61 granted grant VBN 10_1101-2020_03_27_012757 992 62 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 992 63 a a DT 10_1101-2020_03_27_012757 992 64 license license NN 10_1101-2020_03_27_012757 992 65 to to TO 10_1101-2020_03_27_012757 992 66 display display VB 10_1101-2020_03_27_012757 992 67 the the DT 10_1101-2020_03_27_012757 992 68 preprint preprint NN 10_1101-2020_03_27_012757 992 69 in in IN 10_1101-2020_03_27_012757 992 70 perpetuity perpetuity NN 10_1101-2020_03_27_012757 992 71 . . . 10_1101-2020_03_27_012757 993 1 It -PRON- PRP 10_1101-2020_03_27_012757 993 2 is be VBZ 10_1101-2020_03_27_012757 993 3 made make VBN 10_1101-2020_03_27_012757 993 4 The the DT 10_1101-2020_03_27_012757 993 5 copyright copyright NN 10_1101-2020_03_27_012757 993 6 holder holder NN 10_1101-2020_03_27_012757 993 7 for for IN 10_1101-2020_03_27_012757 993 8 this this DT 10_1101-2020_03_27_012757 993 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 993 10 version version NN 10_1101-2020_03_27_012757 993 11 posted post VBD 10_1101-2020_03_27_012757 993 12 January January NNP 10_1101-2020_03_27_012757 993 13 9 9 CD 10_1101-2020_03_27_012757 993 14 , , , 10_1101-2020_03_27_012757 993 15 2021 2021 CD 10_1101-2020_03_27_012757 993 16 . . . 10_1101-2020_03_27_012757 993 17 ; ; : 10_1101-2020_03_27_012757 993 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 993 19 : : : 10_1101-2020_03_27_012757 993 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 993 21 preprint preprint NN 10_1101-2020_03_27_012757 993 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 993 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 993 24 Supplemental Supplemental NNP 10_1101-2020_03_27_012757 993 25 Figure Figure NNP 10_1101-2020_03_27_012757 993 26 3 3 CD 10_1101-2020_03_27_012757 993 27 C c NN 10_1101-2020_03_27_012757 993 28 D d NN 10_1101-2020_03_27_012757 993 29 A a NN 10_1101-2020_03_27_012757 993 30 B b NN 10_1101-2020_03_27_012757 993 31 .CC .CC , 10_1101-2020_03_27_012757 993 32 - - HYPH 10_1101-2020_03_27_012757 993 33 BY by IN 10_1101-2020_03_27_012757 993 34 - - HYPH 10_1101-2020_03_27_012757 993 35 NC NC NNP 10_1101-2020_03_27_012757 993 36 - - HYPH 10_1101-2020_03_27_012757 993 37 ND ND NNP 10_1101-2020_03_27_012757 993 38 4.0 4.0 CD 10_1101-2020_03_27_012757 993 39 International International NNP 10_1101-2020_03_27_012757 993 40 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 993 41 under under IN 10_1101-2020_03_27_012757 993 42 a a DT 10_1101-2020_03_27_012757 993 43 ( ( -LRB- 10_1101-2020_03_27_012757 993 44 which which WDT 10_1101-2020_03_27_012757 993 45 was be VBD 10_1101-2020_03_27_012757 993 46 not not RB 10_1101-2020_03_27_012757 993 47 certified certify VBN 10_1101-2020_03_27_012757 993 48 by by IN 10_1101-2020_03_27_012757 993 49 peer peer NN 10_1101-2020_03_27_012757 993 50 review review NN 10_1101-2020_03_27_012757 993 51 ) ) -RRB- 10_1101-2020_03_27_012757 993 52 is be VBZ 10_1101-2020_03_27_012757 993 53 the the DT 10_1101-2020_03_27_012757 993 54 author author NN 10_1101-2020_03_27_012757 993 55 / / SYM 10_1101-2020_03_27_012757 993 56 funder funder NN 10_1101-2020_03_27_012757 993 57 , , , 10_1101-2020_03_27_012757 993 58 who who WP 10_1101-2020_03_27_012757 993 59 has have VBZ 10_1101-2020_03_27_012757 993 60 granted grant VBN 10_1101-2020_03_27_012757 993 61 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 993 62 a a DT 10_1101-2020_03_27_012757 993 63 license license NN 10_1101-2020_03_27_012757 993 64 to to TO 10_1101-2020_03_27_012757 993 65 display display VB 10_1101-2020_03_27_012757 993 66 the the DT 10_1101-2020_03_27_012757 993 67 preprint preprint NN 10_1101-2020_03_27_012757 993 68 in in IN 10_1101-2020_03_27_012757 993 69 perpetuity perpetuity NN 10_1101-2020_03_27_012757 993 70 . . . 10_1101-2020_03_27_012757 994 1 It -PRON- PRP 10_1101-2020_03_27_012757 994 2 is be VBZ 10_1101-2020_03_27_012757 994 3 made make VBN 10_1101-2020_03_27_012757 994 4 The the DT 10_1101-2020_03_27_012757 994 5 copyright copyright NN 10_1101-2020_03_27_012757 994 6 holder holder NN 10_1101-2020_03_27_012757 994 7 for for IN 10_1101-2020_03_27_012757 994 8 this this DT 10_1101-2020_03_27_012757 994 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 994 10 version version NN 10_1101-2020_03_27_012757 994 11 posted post VBD 10_1101-2020_03_27_012757 994 12 January January NNP 10_1101-2020_03_27_012757 994 13 9 9 CD 10_1101-2020_03_27_012757 994 14 , , , 10_1101-2020_03_27_012757 994 15 2021 2021 CD 10_1101-2020_03_27_012757 994 16 . . . 10_1101-2020_03_27_012757 994 17 ; ; : 10_1101-2020_03_27_012757 994 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 994 19 : : : 10_1101-2020_03_27_012757 994 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 994 21 preprint preprint NN 10_1101-2020_03_27_012757 994 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 994 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 994 24 Supplemental Supplemental NNP 10_1101-2020_03_27_012757 994 25 Figure Figure NNP 10_1101-2020_03_27_012757 994 26 4 4 CD 10_1101-2020_03_27_012757 994 27 .CC .CC : 10_1101-2020_03_27_012757 994 28 - - HYPH 10_1101-2020_03_27_012757 994 29 BY by IN 10_1101-2020_03_27_012757 994 30 - - HYPH 10_1101-2020_03_27_012757 994 31 NC NC NNP 10_1101-2020_03_27_012757 994 32 - - HYPH 10_1101-2020_03_27_012757 994 33 ND ND NNP 10_1101-2020_03_27_012757 994 34 4.0 4.0 CD 10_1101-2020_03_27_012757 994 35 International International NNP 10_1101-2020_03_27_012757 994 36 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 994 37 under under IN 10_1101-2020_03_27_012757 994 38 a a DT 10_1101-2020_03_27_012757 994 39 ( ( -LRB- 10_1101-2020_03_27_012757 994 40 which which WDT 10_1101-2020_03_27_012757 994 41 was be VBD 10_1101-2020_03_27_012757 994 42 not not RB 10_1101-2020_03_27_012757 994 43 certified certify VBN 10_1101-2020_03_27_012757 994 44 by by IN 10_1101-2020_03_27_012757 994 45 peer peer NN 10_1101-2020_03_27_012757 994 46 review review NN 10_1101-2020_03_27_012757 994 47 ) ) -RRB- 10_1101-2020_03_27_012757 994 48 is be VBZ 10_1101-2020_03_27_012757 994 49 the the DT 10_1101-2020_03_27_012757 994 50 author author NN 10_1101-2020_03_27_012757 994 51 / / SYM 10_1101-2020_03_27_012757 994 52 funder funder NN 10_1101-2020_03_27_012757 994 53 , , , 10_1101-2020_03_27_012757 994 54 who who WP 10_1101-2020_03_27_012757 994 55 has have VBZ 10_1101-2020_03_27_012757 994 56 granted grant VBN 10_1101-2020_03_27_012757 994 57 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 994 58 a a DT 10_1101-2020_03_27_012757 994 59 license license NN 10_1101-2020_03_27_012757 994 60 to to TO 10_1101-2020_03_27_012757 994 61 display display VB 10_1101-2020_03_27_012757 994 62 the the DT 10_1101-2020_03_27_012757 994 63 preprint preprint NN 10_1101-2020_03_27_012757 994 64 in in IN 10_1101-2020_03_27_012757 994 65 perpetuity perpetuity NN 10_1101-2020_03_27_012757 994 66 . . . 10_1101-2020_03_27_012757 995 1 It -PRON- PRP 10_1101-2020_03_27_012757 995 2 is be VBZ 10_1101-2020_03_27_012757 995 3 made make VBN 10_1101-2020_03_27_012757 995 4 The the DT 10_1101-2020_03_27_012757 995 5 copyright copyright NN 10_1101-2020_03_27_012757 995 6 holder holder NN 10_1101-2020_03_27_012757 995 7 for for IN 10_1101-2020_03_27_012757 995 8 this this DT 10_1101-2020_03_27_012757 995 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 995 10 version version NN 10_1101-2020_03_27_012757 995 11 posted post VBD 10_1101-2020_03_27_012757 995 12 January January NNP 10_1101-2020_03_27_012757 995 13 9 9 CD 10_1101-2020_03_27_012757 995 14 , , , 10_1101-2020_03_27_012757 995 15 2021 2021 CD 10_1101-2020_03_27_012757 995 16 . . . 10_1101-2020_03_27_012757 995 17 ; ; : 10_1101-2020_03_27_012757 995 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 995 19 : : : 10_1101-2020_03_27_012757 995 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 995 21 preprint preprint NN 10_1101-2020_03_27_012757 995 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 995 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2020_03_27_012757 995 24 Supplemental Supplemental NNP 10_1101-2020_03_27_012757 995 25 Figure Figure NNP 10_1101-2020_03_27_012757 995 26 5 5 CD 10_1101-2020_03_27_012757 995 27 .CC .cc SYM 10_1101-2020_03_27_012757 995 28 - - HYPH 10_1101-2020_03_27_012757 995 29 BY by IN 10_1101-2020_03_27_012757 995 30 - - HYPH 10_1101-2020_03_27_012757 995 31 NC NC NNP 10_1101-2020_03_27_012757 995 32 - - HYPH 10_1101-2020_03_27_012757 995 33 ND ND NNP 10_1101-2020_03_27_012757 995 34 4.0 4.0 CD 10_1101-2020_03_27_012757 995 35 International International NNP 10_1101-2020_03_27_012757 995 36 licenseavailable licenseavailable NN 10_1101-2020_03_27_012757 995 37 under under IN 10_1101-2020_03_27_012757 995 38 a a DT 10_1101-2020_03_27_012757 995 39 ( ( -LRB- 10_1101-2020_03_27_012757 995 40 which which WDT 10_1101-2020_03_27_012757 995 41 was be VBD 10_1101-2020_03_27_012757 995 42 not not RB 10_1101-2020_03_27_012757 995 43 certified certify VBN 10_1101-2020_03_27_012757 995 44 by by IN 10_1101-2020_03_27_012757 995 45 peer peer NN 10_1101-2020_03_27_012757 995 46 review review NN 10_1101-2020_03_27_012757 995 47 ) ) -RRB- 10_1101-2020_03_27_012757 995 48 is be VBZ 10_1101-2020_03_27_012757 995 49 the the DT 10_1101-2020_03_27_012757 995 50 author author NN 10_1101-2020_03_27_012757 995 51 / / SYM 10_1101-2020_03_27_012757 995 52 funder funder NN 10_1101-2020_03_27_012757 995 53 , , , 10_1101-2020_03_27_012757 995 54 who who WP 10_1101-2020_03_27_012757 995 55 has have VBZ 10_1101-2020_03_27_012757 995 56 granted grant VBN 10_1101-2020_03_27_012757 995 57 bioRxiv biorxiv IN 10_1101-2020_03_27_012757 995 58 a a DT 10_1101-2020_03_27_012757 995 59 license license NN 10_1101-2020_03_27_012757 995 60 to to TO 10_1101-2020_03_27_012757 995 61 display display VB 10_1101-2020_03_27_012757 995 62 the the DT 10_1101-2020_03_27_012757 995 63 preprint preprint NN 10_1101-2020_03_27_012757 995 64 in in IN 10_1101-2020_03_27_012757 995 65 perpetuity perpetuity NN 10_1101-2020_03_27_012757 995 66 . . . 10_1101-2020_03_27_012757 996 1 It -PRON- PRP 10_1101-2020_03_27_012757 996 2 is be VBZ 10_1101-2020_03_27_012757 996 3 made make VBN 10_1101-2020_03_27_012757 996 4 The the DT 10_1101-2020_03_27_012757 996 5 copyright copyright NN 10_1101-2020_03_27_012757 996 6 holder holder NN 10_1101-2020_03_27_012757 996 7 for for IN 10_1101-2020_03_27_012757 996 8 this this DT 10_1101-2020_03_27_012757 996 9 preprintthis preprintthis NN 10_1101-2020_03_27_012757 996 10 version version NN 10_1101-2020_03_27_012757 996 11 posted post VBD 10_1101-2020_03_27_012757 996 12 January January NNP 10_1101-2020_03_27_012757 996 13 9 9 CD 10_1101-2020_03_27_012757 996 14 , , , 10_1101-2020_03_27_012757 996 15 2021 2021 CD 10_1101-2020_03_27_012757 996 16 . . . 10_1101-2020_03_27_012757 996 17 ; ; : 10_1101-2020_03_27_012757 996 18 https://doi.org/10.1101/2020.03.27.012757doi https://doi.org/10.1101/2020.03.27.012757doi LS 10_1101-2020_03_27_012757 996 19 : : : 10_1101-2020_03_27_012757 996 20 bioRxiv biorxiv VB 10_1101-2020_03_27_012757 996 21 preprint preprint NN 10_1101-2020_03_27_012757 996 22 https://doi.org/10.1101/2020.03.27.012757 https://doi.org/10.1101/2020.03.27.012757 UH 10_1101-2020_03_27_012757 996 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ XX