id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2021_01_04_425315	Chen, Lulu	Sample-wise unsupervised deconvolution of complex tissues	2021	29	.pdf	application/pdf	7333	1028	66	tool enables statistically-principled subtype-level downstream analyses, such as detecting subtypespecific differentially expressed genes (sDEG) and differential dependency networks (DDN) nuclear-norm regularized low-rank matrix factorization problem (Wang, Hoffman et al. regularization to optimize the estimation of between-sample variations in each subtype to recover sample-specific deconvolution and optimization solver used in swCAM algorithm, followed by Sample-specific deconvolution problem formulation and the assumption of hidden low-rank pattern CAM-estimated subtype-specific expression matrix serves as the initial reference 𝑺. The objective function of swCAM for sample-specific deconvolution problem and its reformulation As swCAM focuses on subtype-specific variation estimation, simulating biological variance The observations for 300 genes in 50 samples were simulated with subtype-specific expression Gene co-expressed function modules detected by WGCNA on swCAM estimated sample-specific Gene co-expressed function modules detected by WGCNA on swCAM estimated samplespecific expression for each subtype with λ=5 and δ=1 or 0.1. capacity of swCAM to estimate sample-specific signals in each subtype using simulations where 	./cache/10_1101-2021_01_04_425315.pdf	./txt/10_1101-2021_01_04_425315.txt