id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2020_09_09_289074	Ortuso, Francesco	Structural Genetics of circulating variants affecting the SARS-CoV-2 Spike / human ACE2 complex	2021	23	.pdf	application/pdf	7878	977	67	Structural Genetics of circulating variants affecting the SARS-CoV-2 Spike / human ACE2 complex SARS-CoV-2, COVID-19, mutations, Spike, ACE2 SARS-CoV-2 entry in human cells is mediated by the interaction between the viral Spike protein and protein variants in the SARS-CoV-2 population as the result of mutations, and it is unclear if these SARS-CoV-2 (the COVID-19 virus) and human cells, through the analysis of Spike/ACE2 complexes. future mutations targeting the ACE2/Spike binding and detected by sequencing SARS-CoV-2 on a We obtained structural models of the SARS-CoV-2 Spike interacting with the human ACE2 from three contributing to the interaction between Spike and ACE2, according to GBPM (see Table 1 and Fig 3 for A less frequent mutation amongst those predicted to contribute to the ACE2/Spike interaction is population and non-zero GBPM average score in the ACE2/Spike interaction models. ACE2 variants with non-zero GBPM score in the Spike interaction model.	./cache/10_1101-2020_09_09_289074.pdf	./txt/10_1101-2020_09_09_289074.txt