id sid tid token lemma pos 10_1101-2021_01_06_425584 1 1 37271726 37271726 CD 10_1101-2021_01_06_425584 1 2 1 1 CD 10_1101-2021_01_06_425584 1 3 Comprehensive comprehensive JJ 10_1101-2021_01_06_425584 1 4 multi multi NN 10_1101-2021_01_06_425584 1 5 - - HYPH 10_1101-2021_01_06_425584 1 6 omics omics JJ 10_1101-2021_01_06_425584 1 7 study study NN 10_1101-2021_01_06_425584 1 8 of of IN 10_1101-2021_01_06_425584 1 9 the the DT 10_1101-2021_01_06_425584 1 10 molecular molecular JJ 10_1101-2021_01_06_425584 1 11 perturbations perturbation NNS 10_1101-2021_01_06_425584 1 12 1 1 CD 10_1101-2021_01_06_425584 1 13 induced induce VBN 10_1101-2021_01_06_425584 1 14 by by IN 10_1101-2021_01_06_425584 1 15 simulated simulated JJ 10_1101-2021_01_06_425584 1 16 diabetes diabete NNS 10_1101-2021_01_06_425584 1 17 on on IN 10_1101-2021_01_06_425584 1 18 coronary coronary JJ 10_1101-2021_01_06_425584 1 19 artery artery NN 10_1101-2021_01_06_425584 1 20 endothelial endothelial JJ 10_1101-2021_01_06_425584 1 21 cells cell NNS 10_1101-2021_01_06_425584 1 22 2 2 CD 10_1101-2021_01_06_425584 1 23 3 3 CD 10_1101-2021_01_06_425584 1 24 Aldo Aldo NNP 10_1101-2021_01_06_425584 1 25 Moreno Moreno NNP 10_1101-2021_01_06_425584 1 26 - - HYPH 10_1101-2021_01_06_425584 1 27 Ulloa1,2 Ulloa1,2 NNP 10_1101-2021_01_06_425584 1 28 * * NFP 10_1101-2021_01_06_425584 1 29 , , , 10_1101-2021_01_06_425584 1 30 Hilda Hilda NNP 10_1101-2021_01_06_425584 1 31 Carolina Carolina NNP 10_1101-2021_01_06_425584 1 32 Delgado Delgado NNP 10_1101-2021_01_06_425584 1 33 - - HYPH 10_1101-2021_01_06_425584 1 34 De De NNP 10_1101-2021_01_06_425584 1 35 la la NNP 10_1101-2021_01_06_425584 1 36 Herrán1,3 Herrán1,3 NNP 10_1101-2021_01_06_425584 1 37 , , , 10_1101-2021_01_06_425584 1 38 Carolina Carolina NNP 10_1101-2021_01_06_425584 1 39 Álvarez Álvarez NNP 10_1101-2021_01_06_425584 1 40 - - HYPH 10_1101-2021_01_06_425584 1 41 Delgado3 Delgado3 NNP 10_1101-2021_01_06_425584 1 42 , , , 10_1101-2021_01_06_425584 1 43 4 4 CD 10_1101-2021_01_06_425584 1 44 Omar Omar NNP 10_1101-2021_01_06_425584 1 45 Mendoza Mendoza NNP 10_1101-2021_01_06_425584 1 46 - - HYPH 10_1101-2021_01_06_425584 1 47 Porras4 Porras4 NNP 10_1101-2021_01_06_425584 1 48 , , , 10_1101-2021_01_06_425584 1 49 Rommel Rommel NNP 10_1101-2021_01_06_425584 1 50 A. A. NNP 10_1101-2021_01_06_425584 1 51 Carballo Carballo NNP 10_1101-2021_01_06_425584 1 52 - - HYPH 10_1101-2021_01_06_425584 1 53 Castañeda1 Castañeda1 NNP 10_1101-2021_01_06_425584 1 54 and and CC 10_1101-2021_01_06_425584 1 55 Francisco Francisco NNP 10_1101-2021_01_06_425584 1 56 Villarreal5,6 villarreal5,6 CD 10_1101-2021_01_06_425584 1 57 5 5 CD 10_1101-2021_01_06_425584 1 58 6 6 CD 10_1101-2021_01_06_425584 1 59 1MS2 1ms2 CD 10_1101-2021_01_06_425584 1 60 laboratory laboratory NN 10_1101-2021_01_06_425584 1 61 , , , 10_1101-2021_01_06_425584 1 62 Biomedical Biomedical NNP 10_1101-2021_01_06_425584 1 63 Innovation Innovation NNP 10_1101-2021_01_06_425584 1 64 Department Department NNP 10_1101-2021_01_06_425584 1 65 , , , 10_1101-2021_01_06_425584 1 66 Center Center NNP 10_1101-2021_01_06_425584 1 67 for for IN 10_1101-2021_01_06_425584 1 68 Scientific Scientific NNP 10_1101-2021_01_06_425584 1 69 Research Research NNP 10_1101-2021_01_06_425584 1 70 and and CC 10_1101-2021_01_06_425584 1 71 Higher Higher NNP 10_1101-2021_01_06_425584 1 72 7 7 NNP 10_1101-2021_01_06_425584 1 73 Education Education NNP 10_1101-2021_01_06_425584 1 74 of of IN 10_1101-2021_01_06_425584 1 75 Ensenada Ensenada NNP 10_1101-2021_01_06_425584 1 76 ( ( -LRB- 10_1101-2021_01_06_425584 1 77 CICESE CICESE NNP 10_1101-2021_01_06_425584 1 78 ) ) -RRB- 10_1101-2021_01_06_425584 1 79 , , , 10_1101-2021_01_06_425584 1 80 Baja Baja NNP 10_1101-2021_01_06_425584 1 81 California California NNP 10_1101-2021_01_06_425584 1 82 , , , 10_1101-2021_01_06_425584 1 83 México México NNP 10_1101-2021_01_06_425584 1 84 8 8 CD 10_1101-2021_01_06_425584 1 85 2Specialized 2Specialized NNP 10_1101-2021_01_06_425584 1 86 Laboratory Laboratory NNP 10_1101-2021_01_06_425584 1 87 in in IN 10_1101-2021_01_06_425584 1 88 Metabolomics Metabolomics NNPS 10_1101-2021_01_06_425584 1 89 and and CC 10_1101-2021_01_06_425584 1 90 Proteomics Proteomics NNP 10_1101-2021_01_06_425584 1 91 ( ( -LRB- 10_1101-2021_01_06_425584 1 92 MetPro MetPro NNP 10_1101-2021_01_06_425584 1 93 ) ) -RRB- 10_1101-2021_01_06_425584 1 94 , , , 10_1101-2021_01_06_425584 1 95 CICESE CICESE NNP 10_1101-2021_01_06_425584 1 96 , , , 10_1101-2021_01_06_425584 1 97 México México NNP 10_1101-2021_01_06_425584 1 98 9 9 CD 10_1101-2021_01_06_425584 1 99 3Mitochondrial 3Mitochondrial NNP 10_1101-2021_01_06_425584 1 100 Biology Biology NNP 10_1101-2021_01_06_425584 1 101 Laboratory Laboratory NNP 10_1101-2021_01_06_425584 1 102 , , , 10_1101-2021_01_06_425584 1 103 Biomedical Biomedical NNP 10_1101-2021_01_06_425584 1 104 Innovation Innovation NNP 10_1101-2021_01_06_425584 1 105 Department Department NNP 10_1101-2021_01_06_425584 1 106 , , , 10_1101-2021_01_06_425584 1 107 Center Center NNP 10_1101-2021_01_06_425584 1 108 for for IN 10_1101-2021_01_06_425584 1 109 Scientific Scientific NNP 10_1101-2021_01_06_425584 1 110 10 10 CD 10_1101-2021_01_06_425584 1 111 Research Research NNP 10_1101-2021_01_06_425584 1 112 and and CC 10_1101-2021_01_06_425584 1 113 Higher Higher NNP 10_1101-2021_01_06_425584 1 114 Education Education NNP 10_1101-2021_01_06_425584 1 115 of of IN 10_1101-2021_01_06_425584 1 116 Ensenada Ensenada NNP 10_1101-2021_01_06_425584 1 117 ( ( -LRB- 10_1101-2021_01_06_425584 1 118 CICESE CICESE NNP 10_1101-2021_01_06_425584 1 119 ) ) -RRB- 10_1101-2021_01_06_425584 1 120 , , , 10_1101-2021_01_06_425584 1 121 Baja Baja NNP 10_1101-2021_01_06_425584 1 122 California California NNP 10_1101-2021_01_06_425584 1 123 , , , 10_1101-2021_01_06_425584 1 124 México México NNP 10_1101-2021_01_06_425584 1 125 11 11 CD 10_1101-2021_01_06_425584 1 126 4CSIRO 4csiro CD 10_1101-2021_01_06_425584 1 127 Livestock Livestock NNP 10_1101-2021_01_06_425584 1 128 and and CC 10_1101-2021_01_06_425584 1 129 Aquaculture Aquaculture NNP 10_1101-2021_01_06_425584 1 130 , , , 10_1101-2021_01_06_425584 1 131 Queensland Queensland NNP 10_1101-2021_01_06_425584 1 132 Bioscience Bioscience NNP 10_1101-2021_01_06_425584 1 133 Precinct Precinct NNP 10_1101-2021_01_06_425584 1 134 , , , 10_1101-2021_01_06_425584 1 135 306 306 CD 10_1101-2021_01_06_425584 1 136 Carmody carmody NN 10_1101-2021_01_06_425584 1 137 Rd Rd NNP 10_1101-2021_01_06_425584 1 138 , , , 10_1101-2021_01_06_425584 1 139 St St NNP 10_1101-2021_01_06_425584 1 140 12 12 CD 10_1101-2021_01_06_425584 1 141 Lucia Lucia NNP 10_1101-2021_01_06_425584 1 142 , , , 10_1101-2021_01_06_425584 1 143 QLD QLD NNP 10_1101-2021_01_06_425584 1 144 , , , 10_1101-2021_01_06_425584 1 145 Australia Australia NNP 10_1101-2021_01_06_425584 1 146 13 13 CD 10_1101-2021_01_06_425584 1 147 5School 5school CD 10_1101-2021_01_06_425584 1 148 of of IN 10_1101-2021_01_06_425584 1 149 Medicine Medicine NNP 10_1101-2021_01_06_425584 1 150 , , , 10_1101-2021_01_06_425584 1 151 University University NNP 10_1101-2021_01_06_425584 1 152 of of IN 10_1101-2021_01_06_425584 1 153 California California NNP 10_1101-2021_01_06_425584 1 154 , , , 10_1101-2021_01_06_425584 1 155 San San NNP 10_1101-2021_01_06_425584 1 156 Diego Diego NNP 10_1101-2021_01_06_425584 1 157 , , , 10_1101-2021_01_06_425584 1 158 CA CA NNP 10_1101-2021_01_06_425584 1 159 , , , 10_1101-2021_01_06_425584 1 160 USA USA NNP 10_1101-2021_01_06_425584 1 161 14 14 CD 10_1101-2021_01_06_425584 1 162 6San 6san CD 10_1101-2021_01_06_425584 1 163 Diego Diego NNP 10_1101-2021_01_06_425584 1 164 VA VA NNP 10_1101-2021_01_06_425584 1 165 Healthcare Healthcare NNP 10_1101-2021_01_06_425584 1 166 System System NNP 10_1101-2021_01_06_425584 1 167 15 15 CD 10_1101-2021_01_06_425584 1 168 16 16 CD 10_1101-2021_01_06_425584 1 169 17 17 CD 10_1101-2021_01_06_425584 1 170 18 18 CD 10_1101-2021_01_06_425584 1 171 * * NFP 10_1101-2021_01_06_425584 1 172 To to IN 10_1101-2021_01_06_425584 1 173 whom whom WP 10_1101-2021_01_06_425584 1 174 correspondence correspondence NN 10_1101-2021_01_06_425584 1 175 should should MD 10_1101-2021_01_06_425584 1 176 be be VB 10_1101-2021_01_06_425584 1 177 addressed address VBN 10_1101-2021_01_06_425584 1 178 : : : 10_1101-2021_01_06_425584 1 179 Biomedical Biomedical NNP 10_1101-2021_01_06_425584 1 180 Innovation Innovation NNP 10_1101-2021_01_06_425584 1 181 Department Department NNP 10_1101-2021_01_06_425584 1 182 , , , 10_1101-2021_01_06_425584 1 183 CICESE CICESE NNP 10_1101-2021_01_06_425584 1 184 19 19 CD 10_1101-2021_01_06_425584 1 185 Carretera Carretera NNP 10_1101-2021_01_06_425584 1 186 Ensenada Ensenada NNP 10_1101-2021_01_06_425584 1 187 - - HYPH 10_1101-2021_01_06_425584 1 188 Tijuana Tijuana NNP 10_1101-2021_01_06_425584 1 189 No no NN 10_1101-2021_01_06_425584 1 190 . . . 10_1101-2021_01_06_425584 2 1 3918 3918 CD 10_1101-2021_01_06_425584 2 2 , , , 10_1101-2021_01_06_425584 2 3 Zona Zona NNP 10_1101-2021_01_06_425584 2 4 Playitas Playitas NNP 10_1101-2021_01_06_425584 2 5 , , , 10_1101-2021_01_06_425584 2 6 CP CP NNP 10_1101-2021_01_06_425584 2 7 . . . 10_1101-2021_01_06_425584 3 1 22860 22860 CD 10_1101-2021_01_06_425584 3 2 , , , 10_1101-2021_01_06_425584 3 3 Ensenada Ensenada NNP 10_1101-2021_01_06_425584 3 4 , , , 10_1101-2021_01_06_425584 3 5 B.C. B.C. NNP 10_1101-2021_01_06_425584 4 1 Mexico Mexico NNP 10_1101-2021_01_06_425584 4 2 , , , 10_1101-2021_01_06_425584 4 3 20 20 CD 10_1101-2021_01_06_425584 4 4 Phone phone NN 10_1101-2021_01_06_425584 4 5 : : : 10_1101-2021_01_06_425584 4 6 +52(646)175 +52(646)175 NNP 10_1101-2021_01_06_425584 4 7 - - HYPH 10_1101-2021_01_06_425584 4 8 05 05 CD 10_1101-2021_01_06_425584 4 9 - - HYPH 10_1101-2021_01_06_425584 4 10 00 00 NFP 10_1101-2021_01_06_425584 4 11 ext ext NN 10_1101-2021_01_06_425584 4 12 . . . 10_1101-2021_01_06_425584 5 1 2721 2721 CD 10_1101-2021_01_06_425584 5 2 , , , 10_1101-2021_01_06_425584 5 3 E e NN 10_1101-2021_01_06_425584 5 4 - - NN 10_1101-2021_01_06_425584 5 5 mail mail NN 10_1101-2021_01_06_425584 5 6 : : : 10_1101-2021_01_06_425584 5 7 amoreno@cicese.mx amoreno@cicese.mx CD 10_1101-2021_01_06_425584 5 8 21 21 CD 10_1101-2021_01_06_425584 5 9 22 22 CD 10_1101-2021_01_06_425584 5 10 23 23 CD 10_1101-2021_01_06_425584 5 11 24 24 CD 10_1101-2021_01_06_425584 5 12 .CC .CC : 10_1101-2021_01_06_425584 5 13 - - HYPH 10_1101-2021_01_06_425584 5 14 BY by IN 10_1101-2021_01_06_425584 5 15 - - HYPH 10_1101-2021_01_06_425584 5 16 NC NC NNP 10_1101-2021_01_06_425584 5 17 - - HYPH 10_1101-2021_01_06_425584 5 18 ND ND NNP 10_1101-2021_01_06_425584 5 19 4.0 4.0 CD 10_1101-2021_01_06_425584 5 20 International International NNP 10_1101-2021_01_06_425584 5 21 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 5 22 under under IN 10_1101-2021_01_06_425584 5 23 a a DT 10_1101-2021_01_06_425584 5 24 ( ( -LRB- 10_1101-2021_01_06_425584 5 25 which which WDT 10_1101-2021_01_06_425584 5 26 was be VBD 10_1101-2021_01_06_425584 5 27 not not RB 10_1101-2021_01_06_425584 5 28 certified certify VBN 10_1101-2021_01_06_425584 5 29 by by IN 10_1101-2021_01_06_425584 5 30 peer peer NN 10_1101-2021_01_06_425584 5 31 review review NN 10_1101-2021_01_06_425584 5 32 ) ) -RRB- 10_1101-2021_01_06_425584 5 33 is be VBZ 10_1101-2021_01_06_425584 5 34 the the DT 10_1101-2021_01_06_425584 5 35 author author NN 10_1101-2021_01_06_425584 5 36 / / SYM 10_1101-2021_01_06_425584 5 37 funder funder NN 10_1101-2021_01_06_425584 5 38 , , , 10_1101-2021_01_06_425584 5 39 who who WP 10_1101-2021_01_06_425584 5 40 has have VBZ 10_1101-2021_01_06_425584 5 41 granted grant VBN 10_1101-2021_01_06_425584 5 42 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 5 43 a a DT 10_1101-2021_01_06_425584 5 44 license license NN 10_1101-2021_01_06_425584 5 45 to to TO 10_1101-2021_01_06_425584 5 46 display display VB 10_1101-2021_01_06_425584 5 47 the the DT 10_1101-2021_01_06_425584 5 48 preprint preprint NN 10_1101-2021_01_06_425584 5 49 in in IN 10_1101-2021_01_06_425584 5 50 perpetuity perpetuity NN 10_1101-2021_01_06_425584 5 51 . . . 10_1101-2021_01_06_425584 6 1 It -PRON- PRP 10_1101-2021_01_06_425584 6 2 is be VBZ 10_1101-2021_01_06_425584 6 3 made make VBN 10_1101-2021_01_06_425584 6 4 The the DT 10_1101-2021_01_06_425584 6 5 copyright copyright NN 10_1101-2021_01_06_425584 6 6 holder holder NN 10_1101-2021_01_06_425584 6 7 for for IN 10_1101-2021_01_06_425584 6 8 this this DT 10_1101-2021_01_06_425584 6 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 6 10 version version NN 10_1101-2021_01_06_425584 6 11 posted post VBD 10_1101-2021_01_06_425584 6 12 January January NNP 10_1101-2021_01_06_425584 6 13 8 8 CD 10_1101-2021_01_06_425584 6 14 , , , 10_1101-2021_01_06_425584 6 15 2021 2021 CD 10_1101-2021_01_06_425584 6 16 . . . 10_1101-2021_01_06_425584 6 17 ; ; : 10_1101-2021_01_06_425584 6 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 6 19 : : : 10_1101-2021_01_06_425584 6 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 6 21 preprint preprint NN 10_1101-2021_01_06_425584 6 22 .CC .CC NFP 10_1101-2021_01_06_425584 6 23 - - : 10_1101-2021_01_06_425584 6 24 BY by IN 10_1101-2021_01_06_425584 6 25 - - HYPH 10_1101-2021_01_06_425584 6 26 NC NC NNP 10_1101-2021_01_06_425584 6 27 - - HYPH 10_1101-2021_01_06_425584 6 28 ND ND NNP 10_1101-2021_01_06_425584 6 29 4.0 4.0 CD 10_1101-2021_01_06_425584 6 30 International International NNP 10_1101-2021_01_06_425584 6 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 6 32 under under IN 10_1101-2021_01_06_425584 6 33 a a DT 10_1101-2021_01_06_425584 6 34 ( ( -LRB- 10_1101-2021_01_06_425584 6 35 which which WDT 10_1101-2021_01_06_425584 6 36 was be VBD 10_1101-2021_01_06_425584 6 37 not not RB 10_1101-2021_01_06_425584 6 38 certified certify VBN 10_1101-2021_01_06_425584 6 39 by by IN 10_1101-2021_01_06_425584 6 40 peer peer NN 10_1101-2021_01_06_425584 6 41 review review NN 10_1101-2021_01_06_425584 6 42 ) ) -RRB- 10_1101-2021_01_06_425584 6 43 is be VBZ 10_1101-2021_01_06_425584 6 44 the the DT 10_1101-2021_01_06_425584 6 45 author author NN 10_1101-2021_01_06_425584 6 46 / / SYM 10_1101-2021_01_06_425584 6 47 funder funder NN 10_1101-2021_01_06_425584 6 48 , , , 10_1101-2021_01_06_425584 6 49 who who WP 10_1101-2021_01_06_425584 6 50 has have VBZ 10_1101-2021_01_06_425584 6 51 granted grant VBN 10_1101-2021_01_06_425584 6 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 6 53 a a DT 10_1101-2021_01_06_425584 6 54 license license NN 10_1101-2021_01_06_425584 6 55 to to TO 10_1101-2021_01_06_425584 6 56 display display VB 10_1101-2021_01_06_425584 6 57 the the DT 10_1101-2021_01_06_425584 6 58 preprint preprint NN 10_1101-2021_01_06_425584 6 59 in in IN 10_1101-2021_01_06_425584 6 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 6 61 . . . 10_1101-2021_01_06_425584 7 1 It -PRON- PRP 10_1101-2021_01_06_425584 7 2 is be VBZ 10_1101-2021_01_06_425584 7 3 made make VBN 10_1101-2021_01_06_425584 7 4 The the DT 10_1101-2021_01_06_425584 7 5 copyright copyright NN 10_1101-2021_01_06_425584 7 6 holder holder NN 10_1101-2021_01_06_425584 7 7 for for IN 10_1101-2021_01_06_425584 7 8 this this DT 10_1101-2021_01_06_425584 7 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 7 10 version version NN 10_1101-2021_01_06_425584 7 11 posted post VBD 10_1101-2021_01_06_425584 7 12 January January NNP 10_1101-2021_01_06_425584 7 13 8 8 CD 10_1101-2021_01_06_425584 7 14 , , , 10_1101-2021_01_06_425584 7 15 2021 2021 CD 10_1101-2021_01_06_425584 7 16 . . . 10_1101-2021_01_06_425584 7 17 ; ; : 10_1101-2021_01_06_425584 7 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 7 19 : : : 10_1101-2021_01_06_425584 7 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 7 21 preprint preprint NN 10_1101-2021_01_06_425584 7 22 .CC .CC NFP 10_1101-2021_01_06_425584 7 23 - - : 10_1101-2021_01_06_425584 7 24 BY by IN 10_1101-2021_01_06_425584 7 25 - - HYPH 10_1101-2021_01_06_425584 7 26 NC NC NNP 10_1101-2021_01_06_425584 7 27 - - HYPH 10_1101-2021_01_06_425584 7 28 ND ND NNP 10_1101-2021_01_06_425584 7 29 4.0 4.0 CD 10_1101-2021_01_06_425584 7 30 International International NNP 10_1101-2021_01_06_425584 7 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 7 32 under under IN 10_1101-2021_01_06_425584 7 33 a a DT 10_1101-2021_01_06_425584 7 34 ( ( -LRB- 10_1101-2021_01_06_425584 7 35 which which WDT 10_1101-2021_01_06_425584 7 36 was be VBD 10_1101-2021_01_06_425584 7 37 not not RB 10_1101-2021_01_06_425584 7 38 certified certify VBN 10_1101-2021_01_06_425584 7 39 by by IN 10_1101-2021_01_06_425584 7 40 peer peer NN 10_1101-2021_01_06_425584 7 41 review review NN 10_1101-2021_01_06_425584 7 42 ) ) -RRB- 10_1101-2021_01_06_425584 7 43 is be VBZ 10_1101-2021_01_06_425584 7 44 the the DT 10_1101-2021_01_06_425584 7 45 author author NN 10_1101-2021_01_06_425584 7 46 / / SYM 10_1101-2021_01_06_425584 7 47 funder funder NN 10_1101-2021_01_06_425584 7 48 , , , 10_1101-2021_01_06_425584 7 49 who who WP 10_1101-2021_01_06_425584 7 50 has have VBZ 10_1101-2021_01_06_425584 7 51 granted grant VBN 10_1101-2021_01_06_425584 7 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 7 53 a a DT 10_1101-2021_01_06_425584 7 54 license license NN 10_1101-2021_01_06_425584 7 55 to to TO 10_1101-2021_01_06_425584 7 56 display display VB 10_1101-2021_01_06_425584 7 57 the the DT 10_1101-2021_01_06_425584 7 58 preprint preprint NN 10_1101-2021_01_06_425584 7 59 in in IN 10_1101-2021_01_06_425584 7 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 7 61 . . . 10_1101-2021_01_06_425584 8 1 It -PRON- PRP 10_1101-2021_01_06_425584 8 2 is be VBZ 10_1101-2021_01_06_425584 8 3 made make VBN 10_1101-2021_01_06_425584 8 4 The the DT 10_1101-2021_01_06_425584 8 5 copyright copyright NN 10_1101-2021_01_06_425584 8 6 holder holder NN 10_1101-2021_01_06_425584 8 7 for for IN 10_1101-2021_01_06_425584 8 8 this this DT 10_1101-2021_01_06_425584 8 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 8 10 version version NN 10_1101-2021_01_06_425584 8 11 posted post VBD 10_1101-2021_01_06_425584 8 12 January January NNP 10_1101-2021_01_06_425584 8 13 8 8 CD 10_1101-2021_01_06_425584 8 14 , , , 10_1101-2021_01_06_425584 8 15 2021 2021 CD 10_1101-2021_01_06_425584 8 16 . . . 10_1101-2021_01_06_425584 8 17 ; ; : 10_1101-2021_01_06_425584 8 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 8 19 : : : 10_1101-2021_01_06_425584 8 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 8 21 preprint preprint NN 10_1101-2021_01_06_425584 8 22 .CC .CC NFP 10_1101-2021_01_06_425584 8 23 - - : 10_1101-2021_01_06_425584 8 24 BY by IN 10_1101-2021_01_06_425584 8 25 - - HYPH 10_1101-2021_01_06_425584 8 26 NC NC NNP 10_1101-2021_01_06_425584 8 27 - - HYPH 10_1101-2021_01_06_425584 8 28 ND ND NNP 10_1101-2021_01_06_425584 8 29 4.0 4.0 CD 10_1101-2021_01_06_425584 8 30 International International NNP 10_1101-2021_01_06_425584 8 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 8 32 under under IN 10_1101-2021_01_06_425584 8 33 a a DT 10_1101-2021_01_06_425584 8 34 ( ( -LRB- 10_1101-2021_01_06_425584 8 35 which which WDT 10_1101-2021_01_06_425584 8 36 was be VBD 10_1101-2021_01_06_425584 8 37 not not RB 10_1101-2021_01_06_425584 8 38 certified certify VBN 10_1101-2021_01_06_425584 8 39 by by IN 10_1101-2021_01_06_425584 8 40 peer peer NN 10_1101-2021_01_06_425584 8 41 review review NN 10_1101-2021_01_06_425584 8 42 ) ) -RRB- 10_1101-2021_01_06_425584 8 43 is be VBZ 10_1101-2021_01_06_425584 8 44 the the DT 10_1101-2021_01_06_425584 8 45 author author NN 10_1101-2021_01_06_425584 8 46 / / SYM 10_1101-2021_01_06_425584 8 47 funder funder NN 10_1101-2021_01_06_425584 8 48 , , , 10_1101-2021_01_06_425584 8 49 who who WP 10_1101-2021_01_06_425584 8 50 has have VBZ 10_1101-2021_01_06_425584 8 51 granted grant VBN 10_1101-2021_01_06_425584 8 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 8 53 a a DT 10_1101-2021_01_06_425584 8 54 license license NN 10_1101-2021_01_06_425584 8 55 to to TO 10_1101-2021_01_06_425584 8 56 display display VB 10_1101-2021_01_06_425584 8 57 the the DT 10_1101-2021_01_06_425584 8 58 preprint preprint NN 10_1101-2021_01_06_425584 8 59 in in IN 10_1101-2021_01_06_425584 8 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 8 61 . . . 10_1101-2021_01_06_425584 9 1 It -PRON- PRP 10_1101-2021_01_06_425584 9 2 is be VBZ 10_1101-2021_01_06_425584 9 3 made make VBN 10_1101-2021_01_06_425584 9 4 The the DT 10_1101-2021_01_06_425584 9 5 copyright copyright NN 10_1101-2021_01_06_425584 9 6 holder holder NN 10_1101-2021_01_06_425584 9 7 for for IN 10_1101-2021_01_06_425584 9 8 this this DT 10_1101-2021_01_06_425584 9 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 9 10 version version NN 10_1101-2021_01_06_425584 9 11 posted post VBD 10_1101-2021_01_06_425584 9 12 January January NNP 10_1101-2021_01_06_425584 9 13 8 8 CD 10_1101-2021_01_06_425584 9 14 , , , 10_1101-2021_01_06_425584 9 15 2021 2021 CD 10_1101-2021_01_06_425584 9 16 . . . 10_1101-2021_01_06_425584 9 17 ; ; : 10_1101-2021_01_06_425584 9 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 9 19 : : : 10_1101-2021_01_06_425584 9 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 9 21 preprint preprint NN 10_1101-2021_01_06_425584 9 22 .CC .CC NFP 10_1101-2021_01_06_425584 9 23 - - : 10_1101-2021_01_06_425584 9 24 BY by IN 10_1101-2021_01_06_425584 9 25 - - HYPH 10_1101-2021_01_06_425584 9 26 NC NC NNP 10_1101-2021_01_06_425584 9 27 - - HYPH 10_1101-2021_01_06_425584 9 28 ND ND NNP 10_1101-2021_01_06_425584 9 29 4.0 4.0 CD 10_1101-2021_01_06_425584 9 30 International International NNP 10_1101-2021_01_06_425584 9 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 9 32 under under IN 10_1101-2021_01_06_425584 9 33 a a DT 10_1101-2021_01_06_425584 9 34 ( ( -LRB- 10_1101-2021_01_06_425584 9 35 which which WDT 10_1101-2021_01_06_425584 9 36 was be VBD 10_1101-2021_01_06_425584 9 37 not not RB 10_1101-2021_01_06_425584 9 38 certified certify VBN 10_1101-2021_01_06_425584 9 39 by by IN 10_1101-2021_01_06_425584 9 40 peer peer NN 10_1101-2021_01_06_425584 9 41 review review NN 10_1101-2021_01_06_425584 9 42 ) ) -RRB- 10_1101-2021_01_06_425584 9 43 is be VBZ 10_1101-2021_01_06_425584 9 44 the the DT 10_1101-2021_01_06_425584 9 45 author author NN 10_1101-2021_01_06_425584 9 46 / / SYM 10_1101-2021_01_06_425584 9 47 funder funder NN 10_1101-2021_01_06_425584 9 48 , , , 10_1101-2021_01_06_425584 9 49 who who WP 10_1101-2021_01_06_425584 9 50 has have VBZ 10_1101-2021_01_06_425584 9 51 granted grant VBN 10_1101-2021_01_06_425584 9 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 9 53 a a DT 10_1101-2021_01_06_425584 9 54 license license NN 10_1101-2021_01_06_425584 9 55 to to TO 10_1101-2021_01_06_425584 9 56 display display VB 10_1101-2021_01_06_425584 9 57 the the DT 10_1101-2021_01_06_425584 9 58 preprint preprint NN 10_1101-2021_01_06_425584 9 59 in in IN 10_1101-2021_01_06_425584 9 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 9 61 . . . 10_1101-2021_01_06_425584 10 1 It -PRON- PRP 10_1101-2021_01_06_425584 10 2 is be VBZ 10_1101-2021_01_06_425584 10 3 made make VBN 10_1101-2021_01_06_425584 10 4 The the DT 10_1101-2021_01_06_425584 10 5 copyright copyright NN 10_1101-2021_01_06_425584 10 6 holder holder NN 10_1101-2021_01_06_425584 10 7 for for IN 10_1101-2021_01_06_425584 10 8 this this DT 10_1101-2021_01_06_425584 10 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 10 10 version version NN 10_1101-2021_01_06_425584 10 11 posted post VBD 10_1101-2021_01_06_425584 10 12 January January NNP 10_1101-2021_01_06_425584 10 13 8 8 CD 10_1101-2021_01_06_425584 10 14 , , , 10_1101-2021_01_06_425584 10 15 2021 2021 CD 10_1101-2021_01_06_425584 10 16 . . . 10_1101-2021_01_06_425584 10 17 ; ; : 10_1101-2021_01_06_425584 10 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 10 19 : : : 10_1101-2021_01_06_425584 10 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 10 21 preprint preprint NN 10_1101-2021_01_06_425584 10 22 .CC .CC NFP 10_1101-2021_01_06_425584 10 23 - - : 10_1101-2021_01_06_425584 10 24 BY by IN 10_1101-2021_01_06_425584 10 25 - - HYPH 10_1101-2021_01_06_425584 10 26 NC NC NNP 10_1101-2021_01_06_425584 10 27 - - HYPH 10_1101-2021_01_06_425584 10 28 ND ND NNP 10_1101-2021_01_06_425584 10 29 4.0 4.0 CD 10_1101-2021_01_06_425584 10 30 International International NNP 10_1101-2021_01_06_425584 10 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 10 32 under under IN 10_1101-2021_01_06_425584 10 33 a a DT 10_1101-2021_01_06_425584 10 34 ( ( -LRB- 10_1101-2021_01_06_425584 10 35 which which WDT 10_1101-2021_01_06_425584 10 36 was be VBD 10_1101-2021_01_06_425584 10 37 not not RB 10_1101-2021_01_06_425584 10 38 certified certify VBN 10_1101-2021_01_06_425584 10 39 by by IN 10_1101-2021_01_06_425584 10 40 peer peer NN 10_1101-2021_01_06_425584 10 41 review review NN 10_1101-2021_01_06_425584 10 42 ) ) -RRB- 10_1101-2021_01_06_425584 10 43 is be VBZ 10_1101-2021_01_06_425584 10 44 the the DT 10_1101-2021_01_06_425584 10 45 author author NN 10_1101-2021_01_06_425584 10 46 / / SYM 10_1101-2021_01_06_425584 10 47 funder funder NN 10_1101-2021_01_06_425584 10 48 , , , 10_1101-2021_01_06_425584 10 49 who who WP 10_1101-2021_01_06_425584 10 50 has have VBZ 10_1101-2021_01_06_425584 10 51 granted grant VBN 10_1101-2021_01_06_425584 10 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 10 53 a a DT 10_1101-2021_01_06_425584 10 54 license license NN 10_1101-2021_01_06_425584 10 55 to to TO 10_1101-2021_01_06_425584 10 56 display display VB 10_1101-2021_01_06_425584 10 57 the the DT 10_1101-2021_01_06_425584 10 58 preprint preprint NN 10_1101-2021_01_06_425584 10 59 in in IN 10_1101-2021_01_06_425584 10 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 10 61 . . . 10_1101-2021_01_06_425584 11 1 It -PRON- PRP 10_1101-2021_01_06_425584 11 2 is be VBZ 10_1101-2021_01_06_425584 11 3 made make VBN 10_1101-2021_01_06_425584 11 4 The the DT 10_1101-2021_01_06_425584 11 5 copyright copyright NN 10_1101-2021_01_06_425584 11 6 holder holder NN 10_1101-2021_01_06_425584 11 7 for for IN 10_1101-2021_01_06_425584 11 8 this this DT 10_1101-2021_01_06_425584 11 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 11 10 version version NN 10_1101-2021_01_06_425584 11 11 posted post VBD 10_1101-2021_01_06_425584 11 12 January January NNP 10_1101-2021_01_06_425584 11 13 8 8 CD 10_1101-2021_01_06_425584 11 14 , , , 10_1101-2021_01_06_425584 11 15 2021 2021 CD 10_1101-2021_01_06_425584 11 16 . . . 10_1101-2021_01_06_425584 11 17 ; ; : 10_1101-2021_01_06_425584 11 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 11 19 : : : 10_1101-2021_01_06_425584 11 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 11 21 preprint preprint NN 10_1101-2021_01_06_425584 11 22 .CC .CC NFP 10_1101-2021_01_06_425584 11 23 - - : 10_1101-2021_01_06_425584 11 24 BY by IN 10_1101-2021_01_06_425584 11 25 - - HYPH 10_1101-2021_01_06_425584 11 26 NC NC NNP 10_1101-2021_01_06_425584 11 27 - - HYPH 10_1101-2021_01_06_425584 11 28 ND ND NNP 10_1101-2021_01_06_425584 11 29 4.0 4.0 CD 10_1101-2021_01_06_425584 11 30 International International NNP 10_1101-2021_01_06_425584 11 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 11 32 under under IN 10_1101-2021_01_06_425584 11 33 a a DT 10_1101-2021_01_06_425584 11 34 ( ( -LRB- 10_1101-2021_01_06_425584 11 35 which which WDT 10_1101-2021_01_06_425584 11 36 was be VBD 10_1101-2021_01_06_425584 11 37 not not RB 10_1101-2021_01_06_425584 11 38 certified certify VBN 10_1101-2021_01_06_425584 11 39 by by IN 10_1101-2021_01_06_425584 11 40 peer peer NN 10_1101-2021_01_06_425584 11 41 review review NN 10_1101-2021_01_06_425584 11 42 ) ) -RRB- 10_1101-2021_01_06_425584 11 43 is be VBZ 10_1101-2021_01_06_425584 11 44 the the DT 10_1101-2021_01_06_425584 11 45 author author NN 10_1101-2021_01_06_425584 11 46 / / SYM 10_1101-2021_01_06_425584 11 47 funder funder NN 10_1101-2021_01_06_425584 11 48 , , , 10_1101-2021_01_06_425584 11 49 who who WP 10_1101-2021_01_06_425584 11 50 has have VBZ 10_1101-2021_01_06_425584 11 51 granted grant VBN 10_1101-2021_01_06_425584 11 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 11 53 a a DT 10_1101-2021_01_06_425584 11 54 license license NN 10_1101-2021_01_06_425584 11 55 to to TO 10_1101-2021_01_06_425584 11 56 display display VB 10_1101-2021_01_06_425584 11 57 the the DT 10_1101-2021_01_06_425584 11 58 preprint preprint NN 10_1101-2021_01_06_425584 11 59 in in IN 10_1101-2021_01_06_425584 11 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 11 61 . . . 10_1101-2021_01_06_425584 12 1 It -PRON- PRP 10_1101-2021_01_06_425584 12 2 is be VBZ 10_1101-2021_01_06_425584 12 3 made make VBN 10_1101-2021_01_06_425584 12 4 The the DT 10_1101-2021_01_06_425584 12 5 copyright copyright NN 10_1101-2021_01_06_425584 12 6 holder holder NN 10_1101-2021_01_06_425584 12 7 for for IN 10_1101-2021_01_06_425584 12 8 this this DT 10_1101-2021_01_06_425584 12 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 12 10 version version NN 10_1101-2021_01_06_425584 12 11 posted post VBD 10_1101-2021_01_06_425584 12 12 January January NNP 10_1101-2021_01_06_425584 12 13 8 8 CD 10_1101-2021_01_06_425584 12 14 , , , 10_1101-2021_01_06_425584 12 15 2021 2021 CD 10_1101-2021_01_06_425584 12 16 . . . 10_1101-2021_01_06_425584 12 17 ; ; : 10_1101-2021_01_06_425584 12 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 12 19 : : : 10_1101-2021_01_06_425584 12 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 12 21 preprint preprint NN 10_1101-2021_01_06_425584 12 22 .CC .CC NFP 10_1101-2021_01_06_425584 12 23 - - : 10_1101-2021_01_06_425584 12 24 BY by IN 10_1101-2021_01_06_425584 12 25 - - HYPH 10_1101-2021_01_06_425584 12 26 NC NC NNP 10_1101-2021_01_06_425584 12 27 - - HYPH 10_1101-2021_01_06_425584 12 28 ND ND NNP 10_1101-2021_01_06_425584 12 29 4.0 4.0 CD 10_1101-2021_01_06_425584 12 30 International International NNP 10_1101-2021_01_06_425584 12 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 12 32 under under IN 10_1101-2021_01_06_425584 12 33 a a DT 10_1101-2021_01_06_425584 12 34 ( ( -LRB- 10_1101-2021_01_06_425584 12 35 which which WDT 10_1101-2021_01_06_425584 12 36 was be VBD 10_1101-2021_01_06_425584 12 37 not not RB 10_1101-2021_01_06_425584 12 38 certified certify VBN 10_1101-2021_01_06_425584 12 39 by by IN 10_1101-2021_01_06_425584 12 40 peer peer NN 10_1101-2021_01_06_425584 12 41 review review NN 10_1101-2021_01_06_425584 12 42 ) ) -RRB- 10_1101-2021_01_06_425584 12 43 is be VBZ 10_1101-2021_01_06_425584 12 44 the the DT 10_1101-2021_01_06_425584 12 45 author author NN 10_1101-2021_01_06_425584 12 46 / / SYM 10_1101-2021_01_06_425584 12 47 funder funder NN 10_1101-2021_01_06_425584 12 48 , , , 10_1101-2021_01_06_425584 12 49 who who WP 10_1101-2021_01_06_425584 12 50 has have VBZ 10_1101-2021_01_06_425584 12 51 granted grant VBN 10_1101-2021_01_06_425584 12 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 12 53 a a DT 10_1101-2021_01_06_425584 12 54 license license NN 10_1101-2021_01_06_425584 12 55 to to TO 10_1101-2021_01_06_425584 12 56 display display VB 10_1101-2021_01_06_425584 12 57 the the DT 10_1101-2021_01_06_425584 12 58 preprint preprint NN 10_1101-2021_01_06_425584 12 59 in in IN 10_1101-2021_01_06_425584 12 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 12 61 . . . 10_1101-2021_01_06_425584 13 1 It -PRON- PRP 10_1101-2021_01_06_425584 13 2 is be VBZ 10_1101-2021_01_06_425584 13 3 made make VBN 10_1101-2021_01_06_425584 13 4 The the DT 10_1101-2021_01_06_425584 13 5 copyright copyright NN 10_1101-2021_01_06_425584 13 6 holder holder NN 10_1101-2021_01_06_425584 13 7 for for IN 10_1101-2021_01_06_425584 13 8 this this DT 10_1101-2021_01_06_425584 13 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 13 10 version version NN 10_1101-2021_01_06_425584 13 11 posted post VBD 10_1101-2021_01_06_425584 13 12 January January NNP 10_1101-2021_01_06_425584 13 13 8 8 CD 10_1101-2021_01_06_425584 13 14 , , , 10_1101-2021_01_06_425584 13 15 2021 2021 CD 10_1101-2021_01_06_425584 13 16 . . . 10_1101-2021_01_06_425584 13 17 ; ; : 10_1101-2021_01_06_425584 13 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 13 19 : : : 10_1101-2021_01_06_425584 13 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 13 21 preprint preprint NN 10_1101-2021_01_06_425584 13 22 .CC .CC NFP 10_1101-2021_01_06_425584 13 23 - - : 10_1101-2021_01_06_425584 13 24 BY by IN 10_1101-2021_01_06_425584 13 25 - - HYPH 10_1101-2021_01_06_425584 13 26 NC NC NNP 10_1101-2021_01_06_425584 13 27 - - HYPH 10_1101-2021_01_06_425584 13 28 ND ND NNP 10_1101-2021_01_06_425584 13 29 4.0 4.0 CD 10_1101-2021_01_06_425584 13 30 International International NNP 10_1101-2021_01_06_425584 13 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 13 32 under under IN 10_1101-2021_01_06_425584 13 33 a a DT 10_1101-2021_01_06_425584 13 34 ( ( -LRB- 10_1101-2021_01_06_425584 13 35 which which WDT 10_1101-2021_01_06_425584 13 36 was be VBD 10_1101-2021_01_06_425584 13 37 not not RB 10_1101-2021_01_06_425584 13 38 certified certify VBN 10_1101-2021_01_06_425584 13 39 by by IN 10_1101-2021_01_06_425584 13 40 peer peer NN 10_1101-2021_01_06_425584 13 41 review review NN 10_1101-2021_01_06_425584 13 42 ) ) -RRB- 10_1101-2021_01_06_425584 13 43 is be VBZ 10_1101-2021_01_06_425584 13 44 the the DT 10_1101-2021_01_06_425584 13 45 author author NN 10_1101-2021_01_06_425584 13 46 / / SYM 10_1101-2021_01_06_425584 13 47 funder funder NN 10_1101-2021_01_06_425584 13 48 , , , 10_1101-2021_01_06_425584 13 49 who who WP 10_1101-2021_01_06_425584 13 50 has have VBZ 10_1101-2021_01_06_425584 13 51 granted grant VBN 10_1101-2021_01_06_425584 13 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 13 53 a a DT 10_1101-2021_01_06_425584 13 54 license license NN 10_1101-2021_01_06_425584 13 55 to to TO 10_1101-2021_01_06_425584 13 56 display display VB 10_1101-2021_01_06_425584 13 57 the the DT 10_1101-2021_01_06_425584 13 58 preprint preprint NN 10_1101-2021_01_06_425584 13 59 in in IN 10_1101-2021_01_06_425584 13 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 13 61 . . . 10_1101-2021_01_06_425584 14 1 It -PRON- PRP 10_1101-2021_01_06_425584 14 2 is be VBZ 10_1101-2021_01_06_425584 14 3 made make VBN 10_1101-2021_01_06_425584 14 4 The the DT 10_1101-2021_01_06_425584 14 5 copyright copyright NN 10_1101-2021_01_06_425584 14 6 holder holder NN 10_1101-2021_01_06_425584 14 7 for for IN 10_1101-2021_01_06_425584 14 8 this this DT 10_1101-2021_01_06_425584 14 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 14 10 version version NN 10_1101-2021_01_06_425584 14 11 posted post VBD 10_1101-2021_01_06_425584 14 12 January January NNP 10_1101-2021_01_06_425584 14 13 8 8 CD 10_1101-2021_01_06_425584 14 14 , , , 10_1101-2021_01_06_425584 14 15 2021 2021 CD 10_1101-2021_01_06_425584 14 16 . . . 10_1101-2021_01_06_425584 14 17 ; ; : 10_1101-2021_01_06_425584 14 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 14 19 : : : 10_1101-2021_01_06_425584 14 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 14 21 preprint preprint NN 10_1101-2021_01_06_425584 14 22 .CC .CC NFP 10_1101-2021_01_06_425584 14 23 - - : 10_1101-2021_01_06_425584 14 24 BY by IN 10_1101-2021_01_06_425584 14 25 - - HYPH 10_1101-2021_01_06_425584 14 26 NC NC NNP 10_1101-2021_01_06_425584 14 27 - - HYPH 10_1101-2021_01_06_425584 14 28 ND ND NNP 10_1101-2021_01_06_425584 14 29 4.0 4.0 CD 10_1101-2021_01_06_425584 14 30 International International NNP 10_1101-2021_01_06_425584 14 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 14 32 under under IN 10_1101-2021_01_06_425584 14 33 a a DT 10_1101-2021_01_06_425584 14 34 ( ( -LRB- 10_1101-2021_01_06_425584 14 35 which which WDT 10_1101-2021_01_06_425584 14 36 was be VBD 10_1101-2021_01_06_425584 14 37 not not RB 10_1101-2021_01_06_425584 14 38 certified certify VBN 10_1101-2021_01_06_425584 14 39 by by IN 10_1101-2021_01_06_425584 14 40 peer peer NN 10_1101-2021_01_06_425584 14 41 review review NN 10_1101-2021_01_06_425584 14 42 ) ) -RRB- 10_1101-2021_01_06_425584 14 43 is be VBZ 10_1101-2021_01_06_425584 14 44 the the DT 10_1101-2021_01_06_425584 14 45 author author NN 10_1101-2021_01_06_425584 14 46 / / SYM 10_1101-2021_01_06_425584 14 47 funder funder NN 10_1101-2021_01_06_425584 14 48 , , , 10_1101-2021_01_06_425584 14 49 who who WP 10_1101-2021_01_06_425584 14 50 has have VBZ 10_1101-2021_01_06_425584 14 51 granted grant VBN 10_1101-2021_01_06_425584 14 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 14 53 a a DT 10_1101-2021_01_06_425584 14 54 license license NN 10_1101-2021_01_06_425584 14 55 to to TO 10_1101-2021_01_06_425584 14 56 display display VB 10_1101-2021_01_06_425584 14 57 the the DT 10_1101-2021_01_06_425584 14 58 preprint preprint NN 10_1101-2021_01_06_425584 14 59 in in IN 10_1101-2021_01_06_425584 14 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 14 61 . . . 10_1101-2021_01_06_425584 15 1 It -PRON- PRP 10_1101-2021_01_06_425584 15 2 is be VBZ 10_1101-2021_01_06_425584 15 3 made make VBN 10_1101-2021_01_06_425584 15 4 The the DT 10_1101-2021_01_06_425584 15 5 copyright copyright NN 10_1101-2021_01_06_425584 15 6 holder holder NN 10_1101-2021_01_06_425584 15 7 for for IN 10_1101-2021_01_06_425584 15 8 this this DT 10_1101-2021_01_06_425584 15 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 15 10 version version NN 10_1101-2021_01_06_425584 15 11 posted post VBD 10_1101-2021_01_06_425584 15 12 January January NNP 10_1101-2021_01_06_425584 15 13 8 8 CD 10_1101-2021_01_06_425584 15 14 , , , 10_1101-2021_01_06_425584 15 15 2021 2021 CD 10_1101-2021_01_06_425584 15 16 . . . 10_1101-2021_01_06_425584 15 17 ; ; : 10_1101-2021_01_06_425584 15 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 15 19 : : : 10_1101-2021_01_06_425584 15 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 15 21 preprint preprint NN 10_1101-2021_01_06_425584 15 22 .CC .CC NFP 10_1101-2021_01_06_425584 15 23 - - : 10_1101-2021_01_06_425584 15 24 BY by IN 10_1101-2021_01_06_425584 15 25 - - HYPH 10_1101-2021_01_06_425584 15 26 NC NC NNP 10_1101-2021_01_06_425584 15 27 - - HYPH 10_1101-2021_01_06_425584 15 28 ND ND NNP 10_1101-2021_01_06_425584 15 29 4.0 4.0 CD 10_1101-2021_01_06_425584 15 30 International International NNP 10_1101-2021_01_06_425584 15 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 15 32 under under IN 10_1101-2021_01_06_425584 15 33 a a DT 10_1101-2021_01_06_425584 15 34 ( ( -LRB- 10_1101-2021_01_06_425584 15 35 which which WDT 10_1101-2021_01_06_425584 15 36 was be VBD 10_1101-2021_01_06_425584 15 37 not not RB 10_1101-2021_01_06_425584 15 38 certified certify VBN 10_1101-2021_01_06_425584 15 39 by by IN 10_1101-2021_01_06_425584 15 40 peer peer NN 10_1101-2021_01_06_425584 15 41 review review NN 10_1101-2021_01_06_425584 15 42 ) ) -RRB- 10_1101-2021_01_06_425584 15 43 is be VBZ 10_1101-2021_01_06_425584 15 44 the the DT 10_1101-2021_01_06_425584 15 45 author author NN 10_1101-2021_01_06_425584 15 46 / / SYM 10_1101-2021_01_06_425584 15 47 funder funder NN 10_1101-2021_01_06_425584 15 48 , , , 10_1101-2021_01_06_425584 15 49 who who WP 10_1101-2021_01_06_425584 15 50 has have VBZ 10_1101-2021_01_06_425584 15 51 granted grant VBN 10_1101-2021_01_06_425584 15 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 15 53 a a DT 10_1101-2021_01_06_425584 15 54 license license NN 10_1101-2021_01_06_425584 15 55 to to TO 10_1101-2021_01_06_425584 15 56 display display VB 10_1101-2021_01_06_425584 15 57 the the DT 10_1101-2021_01_06_425584 15 58 preprint preprint NN 10_1101-2021_01_06_425584 15 59 in in IN 10_1101-2021_01_06_425584 15 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 15 61 . . . 10_1101-2021_01_06_425584 16 1 It -PRON- PRP 10_1101-2021_01_06_425584 16 2 is be VBZ 10_1101-2021_01_06_425584 16 3 made make VBN 10_1101-2021_01_06_425584 16 4 The the DT 10_1101-2021_01_06_425584 16 5 copyright copyright NN 10_1101-2021_01_06_425584 16 6 holder holder NN 10_1101-2021_01_06_425584 16 7 for for IN 10_1101-2021_01_06_425584 16 8 this this DT 10_1101-2021_01_06_425584 16 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 16 10 version version NN 10_1101-2021_01_06_425584 16 11 posted post VBD 10_1101-2021_01_06_425584 16 12 January January NNP 10_1101-2021_01_06_425584 16 13 8 8 CD 10_1101-2021_01_06_425584 16 14 , , , 10_1101-2021_01_06_425584 16 15 2021 2021 CD 10_1101-2021_01_06_425584 16 16 . . . 10_1101-2021_01_06_425584 16 17 ; ; : 10_1101-2021_01_06_425584 16 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 16 19 : : : 10_1101-2021_01_06_425584 16 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 16 21 preprint preprint NN 10_1101-2021_01_06_425584 16 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 24 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 25 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 26 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 27 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 28 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 29 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 30 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 31 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 32 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 33 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 34 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 35 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 36 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 37 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 38 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 39 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 40 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 41 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 42 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 16 43 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 16 44 2 2 CD 10_1101-2021_01_06_425584 16 45 Abstract Abstract NNP 10_1101-2021_01_06_425584 16 46 25 25 CD 10_1101-2021_01_06_425584 16 47 Coronary coronary JJ 10_1101-2021_01_06_425584 16 48 artery artery NN 10_1101-2021_01_06_425584 16 49 endothelial endothelial JJ 10_1101-2021_01_06_425584 16 50 cells cell NNS 10_1101-2021_01_06_425584 16 51 ( ( -LRB- 10_1101-2021_01_06_425584 16 52 CAEC caec NN 10_1101-2021_01_06_425584 16 53 ) ) -RRB- 10_1101-2021_01_06_425584 16 54 exert exert VBP 10_1101-2021_01_06_425584 16 55 an an DT 10_1101-2021_01_06_425584 16 56 important important JJ 10_1101-2021_01_06_425584 16 57 role role NN 10_1101-2021_01_06_425584 16 58 in in IN 10_1101-2021_01_06_425584 16 59 the the DT 10_1101-2021_01_06_425584 16 60 development development NN 10_1101-2021_01_06_425584 16 61 of of IN 10_1101-2021_01_06_425584 16 62 26 26 CD 10_1101-2021_01_06_425584 16 63 cardiovascular cardiovascular JJ 10_1101-2021_01_06_425584 16 64 disease disease NN 10_1101-2021_01_06_425584 16 65 . . . 10_1101-2021_01_06_425584 17 1 Dysfunction dysfunction NN 10_1101-2021_01_06_425584 17 2 of of IN 10_1101-2021_01_06_425584 17 3 CAEC CAEC NNP 10_1101-2021_01_06_425584 17 4 is be VBZ 10_1101-2021_01_06_425584 17 5 associated associate VBN 10_1101-2021_01_06_425584 17 6 with with IN 10_1101-2021_01_06_425584 17 7 cardiovascular cardiovascular JJ 10_1101-2021_01_06_425584 17 8 disease disease NN 10_1101-2021_01_06_425584 17 9 in in IN 10_1101-2021_01_06_425584 17 10 27 27 CD 10_1101-2021_01_06_425584 17 11 subjects subject NNS 10_1101-2021_01_06_425584 17 12 with with IN 10_1101-2021_01_06_425584 17 13 type type NN 10_1101-2021_01_06_425584 17 14 2 2 CD 10_1101-2021_01_06_425584 17 15 diabetes diabetes NN 10_1101-2021_01_06_425584 17 16 mellitus mellitus NN 10_1101-2021_01_06_425584 17 17 ( ( -LRB- 10_1101-2021_01_06_425584 17 18 T2DM T2DM NNP 10_1101-2021_01_06_425584 17 19 ) ) -RRB- 10_1101-2021_01_06_425584 17 20 . . . 10_1101-2021_01_06_425584 18 1 However however RB 10_1101-2021_01_06_425584 18 2 , , , 10_1101-2021_01_06_425584 18 3 comprehensive comprehensive JJ 10_1101-2021_01_06_425584 18 4 studies study NNS 10_1101-2021_01_06_425584 18 5 of of IN 10_1101-2021_01_06_425584 18 6 the the DT 10_1101-2021_01_06_425584 18 7 effects effect NNS 10_1101-2021_01_06_425584 18 8 28 28 CD 10_1101-2021_01_06_425584 18 9 that that IN 10_1101-2021_01_06_425584 18 10 a a DT 10_1101-2021_01_06_425584 18 11 diabetic diabetic JJ 10_1101-2021_01_06_425584 18 12 environment environment NN 10_1101-2021_01_06_425584 18 13 exerts exert NNS 10_1101-2021_01_06_425584 18 14 on on IN 10_1101-2021_01_06_425584 18 15 this this DT 10_1101-2021_01_06_425584 18 16 cellular cellular JJ 10_1101-2021_01_06_425584 18 17 type type NN 10_1101-2021_01_06_425584 18 18 scarce scarce JJ 10_1101-2021_01_06_425584 18 19 . . . 10_1101-2021_01_06_425584 19 1 The the DT 10_1101-2021_01_06_425584 19 2 present present JJ 10_1101-2021_01_06_425584 19 3 study study NN 10_1101-2021_01_06_425584 19 4 characterized characterize VBD 10_1101-2021_01_06_425584 19 5 29 29 CD 10_1101-2021_01_06_425584 19 6 the the DT 10_1101-2021_01_06_425584 19 7 molecular molecular JJ 10_1101-2021_01_06_425584 19 8 perturbations perturbation NNS 10_1101-2021_01_06_425584 19 9 occurring occur VBG 10_1101-2021_01_06_425584 19 10 on on IN 10_1101-2021_01_06_425584 19 11 cultured cultured JJ 10_1101-2021_01_06_425584 19 12 bovine bovine NN 10_1101-2021_01_06_425584 19 13 CAEC caec NN 10_1101-2021_01_06_425584 19 14 subjected subject VBN 10_1101-2021_01_06_425584 19 15 to to IN 10_1101-2021_01_06_425584 19 16 a a DT 10_1101-2021_01_06_425584 19 17 prolonged prolong VBN 10_1101-2021_01_06_425584 19 18 diabetic diabetic JJ 10_1101-2021_01_06_425584 19 19 30 30 CD 10_1101-2021_01_06_425584 19 20 environment environment NN 10_1101-2021_01_06_425584 19 21 ( ( -LRB- 10_1101-2021_01_06_425584 19 22 high high JJ 10_1101-2021_01_06_425584 19 23 glucose glucose NN 10_1101-2021_01_06_425584 19 24 [ [ -LRB- 10_1101-2021_01_06_425584 19 25 HG HG NNP 10_1101-2021_01_06_425584 19 26 ] ] -RRB- 10_1101-2021_01_06_425584 19 27 and and CC 10_1101-2021_01_06_425584 19 28 high high JJ 10_1101-2021_01_06_425584 19 29 insulin insulin NN 10_1101-2021_01_06_425584 19 30 [ [ -LRB- 10_1101-2021_01_06_425584 19 31 HI HI NNP 10_1101-2021_01_06_425584 19 32 ] ] -RRB- 10_1101-2021_01_06_425584 19 33 ) ) -RRB- 10_1101-2021_01_06_425584 19 34 . . . 10_1101-2021_01_06_425584 20 1 Changes change NNS 10_1101-2021_01_06_425584 20 2 at at IN 10_1101-2021_01_06_425584 20 3 the the DT 10_1101-2021_01_06_425584 20 4 metabolite metabolite JJ 10_1101-2021_01_06_425584 20 5 and and CC 10_1101-2021_01_06_425584 20 6 peptide peptide JJ 10_1101-2021_01_06_425584 20 7 31 31 CD 10_1101-2021_01_06_425584 20 8 level level NN 10_1101-2021_01_06_425584 20 9 were be VBD 10_1101-2021_01_06_425584 20 10 assessed assess VBN 10_1101-2021_01_06_425584 20 11 by by IN 10_1101-2021_01_06_425584 20 12 untargeted untargeted JJ 10_1101-2021_01_06_425584 20 13 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 20 14 and and CC 10_1101-2021_01_06_425584 20 15 chemoinformatics chemoinformatic NNS 10_1101-2021_01_06_425584 20 16 , , , 10_1101-2021_01_06_425584 20 17 and and CC 10_1101-2021_01_06_425584 20 18 the the DT 10_1101-2021_01_06_425584 20 19 results result NNS 10_1101-2021_01_06_425584 20 20 were be VBD 10_1101-2021_01_06_425584 20 21 32 32 CD 10_1101-2021_01_06_425584 20 22 integrated integrate VBN 10_1101-2021_01_06_425584 20 23 with with IN 10_1101-2021_01_06_425584 20 24 proteomics proteomic NNS 10_1101-2021_01_06_425584 20 25 data datum NNS 10_1101-2021_01_06_425584 20 26 using use VBG 10_1101-2021_01_06_425584 20 27 published publish VBN 10_1101-2021_01_06_425584 20 28 SWATH SWATH NNP 10_1101-2021_01_06_425584 20 29 - - HYPH 10_1101-2021_01_06_425584 20 30 based base VBN 10_1101-2021_01_06_425584 20 31 proteomics proteomic NNS 10_1101-2021_01_06_425584 20 32 on on IN 10_1101-2021_01_06_425584 20 33 the the DT 10_1101-2021_01_06_425584 20 34 same same JJ 10_1101-2021_01_06_425584 20 35 in in FW 10_1101-2021_01_06_425584 20 36 vitro vitro FW 10_1101-2021_01_06_425584 20 37 33 33 CD 10_1101-2021_01_06_425584 20 38 model model NN 10_1101-2021_01_06_425584 20 39 . . . 10_1101-2021_01_06_425584 21 1 Our -PRON- PRP$ 10_1101-2021_01_06_425584 21 2 findings finding NNS 10_1101-2021_01_06_425584 21 3 were be VBD 10_1101-2021_01_06_425584 21 4 consistent consistent JJ 10_1101-2021_01_06_425584 21 5 with with IN 10_1101-2021_01_06_425584 21 6 reports report NNS 10_1101-2021_01_06_425584 21 7 on on IN 10_1101-2021_01_06_425584 21 8 other other JJ 10_1101-2021_01_06_425584 21 9 endothelial endothelial JJ 10_1101-2021_01_06_425584 21 10 cell cell NN 10_1101-2021_01_06_425584 21 11 types type NNS 10_1101-2021_01_06_425584 21 12 , , , 10_1101-2021_01_06_425584 21 13 but but CC 10_1101-2021_01_06_425584 21 14 also also RB 10_1101-2021_01_06_425584 21 15 identified identify VBD 10_1101-2021_01_06_425584 21 16 34 34 CD 10_1101-2021_01_06_425584 21 17 novel novel JJ 10_1101-2021_01_06_425584 21 18 signatures signature NNS 10_1101-2021_01_06_425584 21 19 of of IN 10_1101-2021_01_06_425584 21 20 DNA DNA NNP 10_1101-2021_01_06_425584 21 21 / / SYM 10_1101-2021_01_06_425584 21 22 RNA RNA NNP 10_1101-2021_01_06_425584 21 23 , , , 10_1101-2021_01_06_425584 21 24 aminoacid aminoacid NN 10_1101-2021_01_06_425584 21 25 , , , 10_1101-2021_01_06_425584 21 26 peptide peptide NN 10_1101-2021_01_06_425584 21 27 , , , 10_1101-2021_01_06_425584 21 28 and and CC 10_1101-2021_01_06_425584 21 29 lipid lipid VB 10_1101-2021_01_06_425584 21 30 metabolism metabolism NN 10_1101-2021_01_06_425584 21 31 in in IN 10_1101-2021_01_06_425584 21 32 cells cell NNS 10_1101-2021_01_06_425584 21 33 under under IN 10_1101-2021_01_06_425584 21 34 a a DT 10_1101-2021_01_06_425584 21 35 diabetic diabetic JJ 10_1101-2021_01_06_425584 21 36 35 35 CD 10_1101-2021_01_06_425584 21 37 environment environment NN 10_1101-2021_01_06_425584 21 38 . . . 10_1101-2021_01_06_425584 22 1 Manual manual JJ 10_1101-2021_01_06_425584 22 2 data datum NNS 10_1101-2021_01_06_425584 22 3 inspection inspection NN 10_1101-2021_01_06_425584 22 4 revealed reveal VBD 10_1101-2021_01_06_425584 22 5 disturbances disturbance NNS 10_1101-2021_01_06_425584 22 6 on on IN 10_1101-2021_01_06_425584 22 7 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 22 8 catabolism catabolism NN 10_1101-2021_01_06_425584 22 9 and and CC 10_1101-2021_01_06_425584 22 10 36 36 CD 10_1101-2021_01_06_425584 22 11 biosynthesis biosynthesis NN 10_1101-2021_01_06_425584 22 12 of of IN 10_1101-2021_01_06_425584 22 13 phenylalanine phenylalanine NN 10_1101-2021_01_06_425584 22 14 - - HYPH 10_1101-2021_01_06_425584 22 15 based base VBN 10_1101-2021_01_06_425584 22 16 , , , 10_1101-2021_01_06_425584 22 17 glutathione glutathione NN 10_1101-2021_01_06_425584 22 18 - - HYPH 10_1101-2021_01_06_425584 22 19 based base VBN 10_1101-2021_01_06_425584 22 20 , , , 10_1101-2021_01_06_425584 22 21 and and CC 10_1101-2021_01_06_425584 22 22 proline proline NN 10_1101-2021_01_06_425584 22 23 - - HYPH 10_1101-2021_01_06_425584 22 24 based base VBN 10_1101-2021_01_06_425584 22 25 peptide peptide NN 10_1101-2021_01_06_425584 22 26 metabolites metabolite NNS 10_1101-2021_01_06_425584 22 27 . . . 10_1101-2021_01_06_425584 23 1 37 37 CD 10_1101-2021_01_06_425584 23 2 Fluorescence fluorescence NN 10_1101-2021_01_06_425584 23 3 microscopy microscopy NN 10_1101-2021_01_06_425584 23 4 detected detect VBD 10_1101-2021_01_06_425584 23 5 an an DT 10_1101-2021_01_06_425584 23 6 increase increase NN 10_1101-2021_01_06_425584 23 7 in in IN 10_1101-2021_01_06_425584 23 8 binucleation binucleation NN 10_1101-2021_01_06_425584 23 9 in in IN 10_1101-2021_01_06_425584 23 10 cells cell NNS 10_1101-2021_01_06_425584 23 11 under under IN 10_1101-2021_01_06_425584 23 12 treatment treatment NN 10_1101-2021_01_06_425584 23 13 that that WDT 10_1101-2021_01_06_425584 23 14 also also RB 10_1101-2021_01_06_425584 23 15 38 38 CD 10_1101-2021_01_06_425584 23 16 occurred occur VBD 10_1101-2021_01_06_425584 23 17 when when WRB 10_1101-2021_01_06_425584 23 18 human human NN 10_1101-2021_01_06_425584 23 19 CAEC CAEC NNP 10_1101-2021_01_06_425584 23 20 were be VBD 10_1101-2021_01_06_425584 23 21 used use VBN 10_1101-2021_01_06_425584 23 22 . . . 10_1101-2021_01_06_425584 24 1 This this DT 10_1101-2021_01_06_425584 24 2 multi multi JJ 10_1101-2021_01_06_425584 24 3 - - HYPH 10_1101-2021_01_06_425584 24 4 omics omics JJ 10_1101-2021_01_06_425584 24 5 study study NN 10_1101-2021_01_06_425584 24 6 identified identify VBD 10_1101-2021_01_06_425584 24 7 particular particular JJ 10_1101-2021_01_06_425584 24 8 molecular molecular JJ 10_1101-2021_01_06_425584 24 9 39 39 CD 10_1101-2021_01_06_425584 24 10 perturbations perturbation NNS 10_1101-2021_01_06_425584 24 11 in in IN 10_1101-2021_01_06_425584 24 12 an an DT 10_1101-2021_01_06_425584 24 13 induced induce VBN 10_1101-2021_01_06_425584 24 14 diabetic diabetic JJ 10_1101-2021_01_06_425584 24 15 environment environment NN 10_1101-2021_01_06_425584 24 16 that that WDT 10_1101-2021_01_06_425584 24 17 could could MD 10_1101-2021_01_06_425584 24 18 help help VB 10_1101-2021_01_06_425584 24 19 unravel unravel VB 10_1101-2021_01_06_425584 24 20 the the DT 10_1101-2021_01_06_425584 24 21 mechanisms mechanism NNS 10_1101-2021_01_06_425584 24 22 40 40 CD 10_1101-2021_01_06_425584 24 23 underlying underlie VBG 10_1101-2021_01_06_425584 24 24 the the DT 10_1101-2021_01_06_425584 24 25 development development NN 10_1101-2021_01_06_425584 24 26 of of IN 10_1101-2021_01_06_425584 24 27 cardiovascular cardiovascular JJ 10_1101-2021_01_06_425584 24 28 disease disease NN 10_1101-2021_01_06_425584 24 29 in in IN 10_1101-2021_01_06_425584 24 30 subjects subject NNS 10_1101-2021_01_06_425584 24 31 with with IN 10_1101-2021_01_06_425584 24 32 T2DM T2DM NNP 10_1101-2021_01_06_425584 24 33 . . . 10_1101-2021_01_06_425584 25 1 41 41 CD 10_1101-2021_01_06_425584 25 2 42 42 CD 10_1101-2021_01_06_425584 25 3 43 43 CD 10_1101-2021_01_06_425584 25 4 Keywords keyword NNS 10_1101-2021_01_06_425584 25 5 : : : 10_1101-2021_01_06_425584 25 6 SWATH SWATH NNP 10_1101-2021_01_06_425584 25 7 - - HYPH 10_1101-2021_01_06_425584 25 8 Proteomics Proteomics NNP 10_1101-2021_01_06_425584 25 9 ; ; : 10_1101-2021_01_06_425584 25 10 Metabolomics metabolomic NNS 10_1101-2021_01_06_425584 25 11 ; ; : 10_1101-2021_01_06_425584 25 12 Type type NN 10_1101-2021_01_06_425584 25 13 2 2 NNP 10_1101-2021_01_06_425584 25 14 Diabetes diabetes NN 10_1101-2021_01_06_425584 25 15 Mellitus Mellitus NNP 10_1101-2021_01_06_425584 25 16 ; ; : 10_1101-2021_01_06_425584 25 17 Endothelial endothelial JJ 10_1101-2021_01_06_425584 25 18 cells cell NNS 10_1101-2021_01_06_425584 25 19 ; ; : 10_1101-2021_01_06_425584 25 20 44 44 CD 10_1101-2021_01_06_425584 25 21 Feature feature NN 10_1101-2021_01_06_425584 25 22 - - HYPH 10_1101-2021_01_06_425584 25 23 Based base VBN 10_1101-2021_01_06_425584 25 24 Molecular Molecular NNP 10_1101-2021_01_06_425584 25 25 Networking Networking NNP 10_1101-2021_01_06_425584 25 26 45 45 CD 10_1101-2021_01_06_425584 25 27 46 46 CD 10_1101-2021_01_06_425584 25 28 47 47 CD 10_1101-2021_01_06_425584 25 29 48 48 CD 10_1101-2021_01_06_425584 25 30 .CC .cc CD 10_1101-2021_01_06_425584 25 31 - - HYPH 10_1101-2021_01_06_425584 25 32 BY by IN 10_1101-2021_01_06_425584 25 33 - - HYPH 10_1101-2021_01_06_425584 25 34 NC NC NNP 10_1101-2021_01_06_425584 25 35 - - HYPH 10_1101-2021_01_06_425584 25 36 ND ND NNP 10_1101-2021_01_06_425584 25 37 4.0 4.0 CD 10_1101-2021_01_06_425584 25 38 International International NNP 10_1101-2021_01_06_425584 25 39 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 25 40 under under IN 10_1101-2021_01_06_425584 25 41 a a DT 10_1101-2021_01_06_425584 25 42 ( ( -LRB- 10_1101-2021_01_06_425584 25 43 which which WDT 10_1101-2021_01_06_425584 25 44 was be VBD 10_1101-2021_01_06_425584 25 45 not not RB 10_1101-2021_01_06_425584 25 46 certified certify VBN 10_1101-2021_01_06_425584 25 47 by by IN 10_1101-2021_01_06_425584 25 48 peer peer NN 10_1101-2021_01_06_425584 25 49 review review NN 10_1101-2021_01_06_425584 25 50 ) ) -RRB- 10_1101-2021_01_06_425584 25 51 is be VBZ 10_1101-2021_01_06_425584 25 52 the the DT 10_1101-2021_01_06_425584 25 53 author author NN 10_1101-2021_01_06_425584 25 54 / / SYM 10_1101-2021_01_06_425584 25 55 funder funder NN 10_1101-2021_01_06_425584 25 56 , , , 10_1101-2021_01_06_425584 25 57 who who WP 10_1101-2021_01_06_425584 25 58 has have VBZ 10_1101-2021_01_06_425584 25 59 granted grant VBN 10_1101-2021_01_06_425584 25 60 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 25 61 a a DT 10_1101-2021_01_06_425584 25 62 license license NN 10_1101-2021_01_06_425584 25 63 to to TO 10_1101-2021_01_06_425584 25 64 display display VB 10_1101-2021_01_06_425584 25 65 the the DT 10_1101-2021_01_06_425584 25 66 preprint preprint NN 10_1101-2021_01_06_425584 25 67 in in IN 10_1101-2021_01_06_425584 25 68 perpetuity perpetuity NN 10_1101-2021_01_06_425584 25 69 . . . 10_1101-2021_01_06_425584 26 1 It -PRON- PRP 10_1101-2021_01_06_425584 26 2 is be VBZ 10_1101-2021_01_06_425584 26 3 made make VBN 10_1101-2021_01_06_425584 26 4 The the DT 10_1101-2021_01_06_425584 26 5 copyright copyright NN 10_1101-2021_01_06_425584 26 6 holder holder NN 10_1101-2021_01_06_425584 26 7 for for IN 10_1101-2021_01_06_425584 26 8 this this DT 10_1101-2021_01_06_425584 26 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 26 10 version version NN 10_1101-2021_01_06_425584 26 11 posted post VBD 10_1101-2021_01_06_425584 26 12 January January NNP 10_1101-2021_01_06_425584 26 13 8 8 CD 10_1101-2021_01_06_425584 26 14 , , , 10_1101-2021_01_06_425584 26 15 2021 2021 CD 10_1101-2021_01_06_425584 26 16 . . . 10_1101-2021_01_06_425584 26 17 ; ; : 10_1101-2021_01_06_425584 26 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 26 19 : : : 10_1101-2021_01_06_425584 26 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 26 21 preprint preprint NN 10_1101-2021_01_06_425584 26 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 26 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 26 24 3 3 CD 10_1101-2021_01_06_425584 26 25 1 1 CD 10_1101-2021_01_06_425584 26 26 . . . 10_1101-2021_01_06_425584 27 1 Introduction introduction NN 10_1101-2021_01_06_425584 27 2 49 49 CD 10_1101-2021_01_06_425584 27 3 Damage damage NN 10_1101-2021_01_06_425584 27 4 to to IN 10_1101-2021_01_06_425584 27 5 coronary coronary JJ 10_1101-2021_01_06_425584 27 6 artery artery NN 10_1101-2021_01_06_425584 27 7 endothelial endothelial JJ 10_1101-2021_01_06_425584 27 8 cells cell NNS 10_1101-2021_01_06_425584 27 9 ( ( -LRB- 10_1101-2021_01_06_425584 27 10 CAEC caec NN 10_1101-2021_01_06_425584 27 11 ) ) -RRB- 10_1101-2021_01_06_425584 27 12 leads lead VBZ 10_1101-2021_01_06_425584 27 13 to to IN 10_1101-2021_01_06_425584 27 14 coronary coronary JJ 10_1101-2021_01_06_425584 27 15 endothelial endothelial JJ 10_1101-2021_01_06_425584 27 16 dysfunction dysfunction NN 10_1101-2021_01_06_425584 27 17 , , , 10_1101-2021_01_06_425584 27 18 50 50 CD 10_1101-2021_01_06_425584 27 19 which which WDT 10_1101-2021_01_06_425584 27 20 is be VBZ 10_1101-2021_01_06_425584 27 21 associated associate VBN 10_1101-2021_01_06_425584 27 22 with with IN 10_1101-2021_01_06_425584 27 23 the the DT 10_1101-2021_01_06_425584 27 24 development development NN 10_1101-2021_01_06_425584 27 25 of of IN 10_1101-2021_01_06_425584 27 26 cardiac cardiac JJ 10_1101-2021_01_06_425584 27 27 pathologies pathology NNS 10_1101-2021_01_06_425584 27 28 in in IN 10_1101-2021_01_06_425584 27 29 subjects subject NNS 10_1101-2021_01_06_425584 27 30 with with IN 10_1101-2021_01_06_425584 27 31 and and CC 10_1101-2021_01_06_425584 27 32 without without IN 10_1101-2021_01_06_425584 27 33 51 51 CD 10_1101-2021_01_06_425584 27 34 coronary coronary JJ 10_1101-2021_01_06_425584 27 35 atherosclerosis atherosclerosis NN 10_1101-2021_01_06_425584 27 36 ( ( -LRB- 10_1101-2021_01_06_425584 27 37 1 1 CD 10_1101-2021_01_06_425584 27 38 ) ) -RRB- 10_1101-2021_01_06_425584 27 39 . . . 10_1101-2021_01_06_425584 28 1 Subjects subject NNS 10_1101-2021_01_06_425584 28 2 with with IN 10_1101-2021_01_06_425584 28 3 type type NN 10_1101-2021_01_06_425584 28 4 2 2 CD 10_1101-2021_01_06_425584 28 5 diabetes diabetes NN 10_1101-2021_01_06_425584 28 6 mellitus mellitus NN 10_1101-2021_01_06_425584 28 7 ( ( -LRB- 10_1101-2021_01_06_425584 28 8 T2DM T2DM NNP 10_1101-2021_01_06_425584 28 9 ) ) -RRB- 10_1101-2021_01_06_425584 28 10 are be VBP 10_1101-2021_01_06_425584 28 11 particularly particularly RB 10_1101-2021_01_06_425584 28 12 at at IN 10_1101-2021_01_06_425584 28 13 52 52 CD 10_1101-2021_01_06_425584 28 14 increased increase VBN 10_1101-2021_01_06_425584 28 15 risk risk NN 10_1101-2021_01_06_425584 28 16 of of IN 10_1101-2021_01_06_425584 28 17 myocardial myocardial JJ 10_1101-2021_01_06_425584 28 18 infarction infarction NN 10_1101-2021_01_06_425584 28 19 ( ( -LRB- 10_1101-2021_01_06_425584 28 20 2 2 CD 10_1101-2021_01_06_425584 28 21 ) ) -RRB- 10_1101-2021_01_06_425584 28 22 and and CC 10_1101-2021_01_06_425584 28 23 coronary coronary JJ 10_1101-2021_01_06_425584 28 24 endothelial endothelial JJ 10_1101-2021_01_06_425584 28 25 dysfunction dysfunction NN 10_1101-2021_01_06_425584 28 26 has have VBZ 10_1101-2021_01_06_425584 28 27 been be VBN 10_1101-2021_01_06_425584 28 28 53 53 CD 10_1101-2021_01_06_425584 28 29 implicated implicate VBN 10_1101-2021_01_06_425584 28 30 in in IN 10_1101-2021_01_06_425584 28 31 the the DT 10_1101-2021_01_06_425584 28 32 prognosis prognosis NN 10_1101-2021_01_06_425584 28 33 ( ( -LRB- 10_1101-2021_01_06_425584 28 34 3 3 CD 10_1101-2021_01_06_425584 28 35 ) ) -RRB- 10_1101-2021_01_06_425584 28 36 . . . 10_1101-2021_01_06_425584 29 1 A a DT 10_1101-2021_01_06_425584 29 2 high high JJ 10_1101-2021_01_06_425584 29 3 - - HYPH 10_1101-2021_01_06_425584 29 4 glucose glucose NN 10_1101-2021_01_06_425584 29 5 ( ( -LRB- 10_1101-2021_01_06_425584 29 6 HG HG NNP 10_1101-2021_01_06_425584 29 7 ) ) -RRB- 10_1101-2021_01_06_425584 29 8 environment environment NN 10_1101-2021_01_06_425584 29 9 — — : 10_1101-2021_01_06_425584 29 10 hallmark hallmark NN 10_1101-2021_01_06_425584 29 11 of of IN 10_1101-2021_01_06_425584 29 12 T2DM T2DM NNP 10_1101-2021_01_06_425584 29 13 — — : 10_1101-2021_01_06_425584 29 14 leads lead VBZ 10_1101-2021_01_06_425584 29 15 to to IN 10_1101-2021_01_06_425584 29 16 54 54 CD 10_1101-2021_01_06_425584 29 17 nitric nitric JJ 10_1101-2021_01_06_425584 29 18 oxide oxide NN 10_1101-2021_01_06_425584 29 19 signaling signaling NN 10_1101-2021_01_06_425584 29 20 , , , 10_1101-2021_01_06_425584 29 21 cell cell NN 10_1101-2021_01_06_425584 29 22 cycle cycle NN 10_1101-2021_01_06_425584 29 23 ( ( -LRB- 10_1101-2021_01_06_425584 29 24 4 4 CD 10_1101-2021_01_06_425584 29 25 ) ) -RRB- 10_1101-2021_01_06_425584 29 26 , , , 10_1101-2021_01_06_425584 29 27 apoptosis apoptosis NN 10_1101-2021_01_06_425584 29 28 ( ( -LRB- 10_1101-2021_01_06_425584 29 29 5 5 CD 10_1101-2021_01_06_425584 29 30 ) ) -RRB- 10_1101-2021_01_06_425584 29 31 , , , 10_1101-2021_01_06_425584 29 32 angiogenesis angiogenesis NN 10_1101-2021_01_06_425584 29 33 ( ( -LRB- 10_1101-2021_01_06_425584 29 34 6 6 CD 10_1101-2021_01_06_425584 29 35 ) ) -RRB- 10_1101-2021_01_06_425584 29 36 , , , 10_1101-2021_01_06_425584 29 37 and and CC 10_1101-2021_01_06_425584 29 38 DNA dna NN 10_1101-2021_01_06_425584 29 39 structure structure NN 10_1101-2021_01_06_425584 29 40 impairment impairment NN 10_1101-2021_01_06_425584 29 41 55 55 CD 10_1101-2021_01_06_425584 29 42 ( ( -LRB- 10_1101-2021_01_06_425584 29 43 7 7 CD 10_1101-2021_01_06_425584 29 44 ) ) -RRB- 10_1101-2021_01_06_425584 29 45 . . . 10_1101-2021_01_06_425584 30 1 However however RB 10_1101-2021_01_06_425584 30 2 , , , 10_1101-2021_01_06_425584 30 3 given give VBN 10_1101-2021_01_06_425584 30 4 the the DT 10_1101-2021_01_06_425584 30 5 intrinsic intrinsic JJ 10_1101-2021_01_06_425584 30 6 heterogeneity heterogeneity NN 10_1101-2021_01_06_425584 30 7 of of IN 10_1101-2021_01_06_425584 30 8 the the DT 10_1101-2021_01_06_425584 30 9 endothelium endothelium NN 10_1101-2021_01_06_425584 30 10 , , , 10_1101-2021_01_06_425584 30 11 the the DT 10_1101-2021_01_06_425584 30 12 molecular molecular JJ 10_1101-2021_01_06_425584 30 13 perturbations perturbation NNS 10_1101-2021_01_06_425584 30 14 56 56 CD 10_1101-2021_01_06_425584 30 15 caused cause VBN 10_1101-2021_01_06_425584 30 16 by by IN 10_1101-2021_01_06_425584 30 17 HG HG NNP 10_1101-2021_01_06_425584 30 18 vary vary VBP 10_1101-2021_01_06_425584 30 19 accordingly accordingly RB 10_1101-2021_01_06_425584 30 20 with with IN 10_1101-2021_01_06_425584 30 21 the the DT 10_1101-2021_01_06_425584 30 22 type type NN 10_1101-2021_01_06_425584 30 23 of of IN 10_1101-2021_01_06_425584 30 24 studied study VBN 10_1101-2021_01_06_425584 30 25 endothelial endothelial JJ 10_1101-2021_01_06_425584 30 26 cells cell NNS 10_1101-2021_01_06_425584 30 27 ( ( -LRB- 10_1101-2021_01_06_425584 30 28 8 8 CD 10_1101-2021_01_06_425584 30 29 , , , 10_1101-2021_01_06_425584 30 30 9 9 CD 10_1101-2021_01_06_425584 30 31 ) ) -RRB- 10_1101-2021_01_06_425584 30 32 . . . 10_1101-2021_01_06_425584 31 1 For for IN 10_1101-2021_01_06_425584 31 2 instance instance NN 10_1101-2021_01_06_425584 31 3 , , , 10_1101-2021_01_06_425584 31 4 57 57 CD 10_1101-2021_01_06_425584 31 5 human human JJ 10_1101-2021_01_06_425584 31 6 microvascular microvascular JJ 10_1101-2021_01_06_425584 31 7 endothelial endothelial JJ 10_1101-2021_01_06_425584 31 8 cells cell NNS 10_1101-2021_01_06_425584 31 9 showed show VBD 10_1101-2021_01_06_425584 31 10 increased increase VBN 10_1101-2021_01_06_425584 31 11 gene gene NN 10_1101-2021_01_06_425584 31 12 expression expression NN 10_1101-2021_01_06_425584 31 13 of of IN 10_1101-2021_01_06_425584 31 14 endothelial endothelial JJ 10_1101-2021_01_06_425584 31 15 nitric nitric NN 10_1101-2021_01_06_425584 31 16 58 58 CD 10_1101-2021_01_06_425584 31 17 oxide oxide NN 10_1101-2021_01_06_425584 31 18 synthase synthase NN 10_1101-2021_01_06_425584 31 19 , , , 10_1101-2021_01_06_425584 31 20 superoxide superoxide NNP 10_1101-2021_01_06_425584 31 21 dismutase dismutase JJ 10_1101-2021_01_06_425584 31 22 1 1 CD 10_1101-2021_01_06_425584 31 23 , , , 10_1101-2021_01_06_425584 31 24 glutathione glutathione NNP 10_1101-2021_01_06_425584 31 25 peroxidase peroxidase VB 10_1101-2021_01_06_425584 31 26 1 1 CD 10_1101-2021_01_06_425584 31 27 , , , 10_1101-2021_01_06_425584 31 28 thioredoxin thioredoxin NN 10_1101-2021_01_06_425584 31 29 reductase reductase NN 10_1101-2021_01_06_425584 31 30 1 1 CD 10_1101-2021_01_06_425584 31 31 and and CC 10_1101-2021_01_06_425584 31 32 59 59 CD 10_1101-2021_01_06_425584 31 33 2 2 CD 10_1101-2021_01_06_425584 31 34 compared compare VBN 10_1101-2021_01_06_425584 31 35 to to IN 10_1101-2021_01_06_425584 31 36 the the DT 10_1101-2021_01_06_425584 31 37 regulation regulation NN 10_1101-2021_01_06_425584 31 38 observed observe VBN 10_1101-2021_01_06_425584 31 39 in in IN 10_1101-2021_01_06_425584 31 40 human human JJ 10_1101-2021_01_06_425584 31 41 umbilical umbilical JJ 10_1101-2021_01_06_425584 31 42 vein vein NN 10_1101-2021_01_06_425584 31 43 endothelial endothelial JJ 10_1101-2021_01_06_425584 31 44 cells cell NNS 10_1101-2021_01_06_425584 31 45 ( ( -LRB- 10_1101-2021_01_06_425584 31 46 HUVEC HUVEC NNP 10_1101-2021_01_06_425584 31 47 ) ) -RRB- 10_1101-2021_01_06_425584 31 48 when when WRB 10_1101-2021_01_06_425584 31 49 60 60 CD 10_1101-2021_01_06_425584 31 50 cultured culture VBN 10_1101-2021_01_06_425584 31 51 in in IN 10_1101-2021_01_06_425584 31 52 HG HG NNP 10_1101-2021_01_06_425584 31 53 for for IN 10_1101-2021_01_06_425584 31 54 24 24 CD 10_1101-2021_01_06_425584 31 55 h. h. NNS 10_1101-2021_01_06_425584 31 56 Furthermore furthermore RB 10_1101-2021_01_06_425584 31 57 , , , 10_1101-2021_01_06_425584 31 58 the the DT 10_1101-2021_01_06_425584 31 59 response response NN 10_1101-2021_01_06_425584 31 60 of of IN 10_1101-2021_01_06_425584 31 61 endothelial endothelial JJ 10_1101-2021_01_06_425584 31 62 cells cell NNS 10_1101-2021_01_06_425584 31 63 to to IN 10_1101-2021_01_06_425584 31 64 HG HG NNP 10_1101-2021_01_06_425584 31 65 is be VBZ 10_1101-2021_01_06_425584 31 66 influenced influence VBN 10_1101-2021_01_06_425584 31 67 by by IN 10_1101-2021_01_06_425584 31 68 the the DT 10_1101-2021_01_06_425584 31 69 61 61 CD 10_1101-2021_01_06_425584 31 70 duration duration NN 10_1101-2021_01_06_425584 31 71 of of IN 10_1101-2021_01_06_425584 31 72 exposure exposure NN 10_1101-2021_01_06_425584 31 73 ( ( -LRB- 10_1101-2021_01_06_425584 31 74 10 10 CD 10_1101-2021_01_06_425584 31 75 , , , 10_1101-2021_01_06_425584 31 76 11 11 CD 10_1101-2021_01_06_425584 31 77 ) ) -RRB- 10_1101-2021_01_06_425584 31 78 as as IN 10_1101-2021_01_06_425584 31 79 demonstrated demonstrate VBN 10_1101-2021_01_06_425584 31 80 in in IN 10_1101-2021_01_06_425584 31 81 bovine bovine JJ 10_1101-2021_01_06_425584 31 82 aortic aortic JJ 10_1101-2021_01_06_425584 31 83 and and CC 10_1101-2021_01_06_425584 31 84 human human JJ 10_1101-2021_01_06_425584 31 85 microvascular microvascular JJ 10_1101-2021_01_06_425584 31 86 62 62 CD 10_1101-2021_01_06_425584 31 87 endothelial endothelial JJ 10_1101-2021_01_06_425584 31 88 cells cell NNS 10_1101-2021_01_06_425584 31 89 where where WRB 10_1101-2021_01_06_425584 31 90 cell cell NN 10_1101-2021_01_06_425584 31 91 proliferation proliferation NN 10_1101-2021_01_06_425584 31 92 and and CC 10_1101-2021_01_06_425584 31 93 apoptosis apoptosis NN 10_1101-2021_01_06_425584 31 94 were be VBD 10_1101-2021_01_06_425584 31 95 higher high JJR 10_1101-2021_01_06_425584 31 96 at at IN 10_1101-2021_01_06_425584 31 97 < < XX 10_1101-2021_01_06_425584 31 98 48 48 CD 10_1101-2021_01_06_425584 31 99 h h NNS 10_1101-2021_01_06_425584 31 100 compared compare VBN 10_1101-2021_01_06_425584 31 101 to to IN 10_1101-2021_01_06_425584 31 102 8 8 CD 10_1101-2021_01_06_425584 31 103 weeks week NNS 10_1101-2021_01_06_425584 31 104 63 63 CD 10_1101-2021_01_06_425584 31 105 of of IN 10_1101-2021_01_06_425584 31 106 exposure exposure NN 10_1101-2021_01_06_425584 31 107 ( ( -LRB- 10_1101-2021_01_06_425584 31 108 10 10 CD 10_1101-2021_01_06_425584 31 109 ) ) -RRB- 10_1101-2021_01_06_425584 31 110 . . . 10_1101-2021_01_06_425584 32 1 In in IN 10_1101-2021_01_06_425584 32 2 another another DT 10_1101-2021_01_06_425584 32 3 example example NN 10_1101-2021_01_06_425584 32 4 of of IN 10_1101-2021_01_06_425584 32 5 time time NN 10_1101-2021_01_06_425584 32 6 - - HYPH 10_1101-2021_01_06_425584 32 7 dependent dependent JJ 10_1101-2021_01_06_425584 32 8 response response NN 10_1101-2021_01_06_425584 32 9 , , , 10_1101-2021_01_06_425584 32 10 increased increased JJ 10_1101-2021_01_06_425584 32 11 apoptosis apoptosis NN 10_1101-2021_01_06_425584 32 12 ( ( -LRB- 10_1101-2021_01_06_425584 32 13 derived derive VBN 10_1101-2021_01_06_425584 32 14 64 64 CD 10_1101-2021_01_06_425584 32 15 from from IN 10_1101-2021_01_06_425584 32 16 DNA dna NN 10_1101-2021_01_06_425584 32 17 fragmentation fragmentation NN 10_1101-2021_01_06_425584 32 18 ) ) -RRB- 10_1101-2021_01_06_425584 32 19 and and CC 10_1101-2021_01_06_425584 32 20 tumor tumor NN 10_1101-2021_01_06_425584 32 21 necrosis necrosis NNP 10_1101-2021_01_06_425584 32 22 factor factor NN 10_1101-2021_01_06_425584 32 23 alpha alpha NN 10_1101-2021_01_06_425584 32 24 protein protein NN 10_1101-2021_01_06_425584 32 25 levels level NNS 10_1101-2021_01_06_425584 32 26 were be VBD 10_1101-2021_01_06_425584 32 27 reported report VBN 10_1101-2021_01_06_425584 32 28 in in IN 10_1101-2021_01_06_425584 32 29 human human JJ 10_1101-2021_01_06_425584 32 30 65 65 CD 10_1101-2021_01_06_425584 32 31 coronary coronary JJ 10_1101-2021_01_06_425584 32 32 artery artery NN 10_1101-2021_01_06_425584 32 33 endothelial endothelial JJ 10_1101-2021_01_06_425584 32 34 cells cell NNS 10_1101-2021_01_06_425584 32 35 ( ( -LRB- 10_1101-2021_01_06_425584 32 36 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 32 37 ) ) -RRB- 10_1101-2021_01_06_425584 32 38 after after IN 10_1101-2021_01_06_425584 32 39 only only RB 10_1101-2021_01_06_425584 32 40 24 24 CD 10_1101-2021_01_06_425584 32 41 h h NN 10_1101-2021_01_06_425584 32 42 of of IN 10_1101-2021_01_06_425584 32 43 incubation incubation NN 10_1101-2021_01_06_425584 32 44 with with IN 10_1101-2021_01_06_425584 32 45 HG HG NNP 10_1101-2021_01_06_425584 32 46 ( ( -LRB- 10_1101-2021_01_06_425584 32 47 5 5 CD 10_1101-2021_01_06_425584 32 48 ) ) -RRB- 10_1101-2021_01_06_425584 32 49 . . . 10_1101-2021_01_06_425584 33 1 Hence hence RB 10_1101-2021_01_06_425584 33 2 , , , 10_1101-2021_01_06_425584 33 3 the the DT 10_1101-2021_01_06_425584 33 4 66 66 CD 10_1101-2021_01_06_425584 33 5 molecular molecular JJ 10_1101-2021_01_06_425584 33 6 response response NN 10_1101-2021_01_06_425584 33 7 to to IN 10_1101-2021_01_06_425584 33 8 HG HG NNP 10_1101-2021_01_06_425584 33 9 can can MD 10_1101-2021_01_06_425584 33 10 not not RB 10_1101-2021_01_06_425584 33 11 be be VB 10_1101-2021_01_06_425584 33 12 generalized generalize VBN 10_1101-2021_01_06_425584 33 13 among among IN 10_1101-2021_01_06_425584 33 14 endothelial endothelial JJ 10_1101-2021_01_06_425584 33 15 cell cell NN 10_1101-2021_01_06_425584 33 16 types type NNS 10_1101-2021_01_06_425584 33 17 . . . 10_1101-2021_01_06_425584 34 1 Previously previously RB 10_1101-2021_01_06_425584 34 2 we -PRON- PRP 10_1101-2021_01_06_425584 34 3 67 67 CD 10_1101-2021_01_06_425584 34 4 reported report VBD 10_1101-2021_01_06_425584 34 5 impaired impaired JJ 10_1101-2021_01_06_425584 34 6 mitochondrial mitochondrial NN 10_1101-2021_01_06_425584 34 7 function function NN 10_1101-2021_01_06_425584 34 8 / / SYM 10_1101-2021_01_06_425584 34 9 structure structure NN 10_1101-2021_01_06_425584 34 10 and and CC 10_1101-2021_01_06_425584 34 11 nitric nitric JJ 10_1101-2021_01_06_425584 34 12 oxide oxide NN 10_1101-2021_01_06_425584 34 13 signaling signal VBG 10_1101-2021_01_06_425584 34 14 in in IN 10_1101-2021_01_06_425584 34 15 HG HG NNP 10_1101-2021_01_06_425584 34 16 treated treat VBN 10_1101-2021_01_06_425584 34 17 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 34 18 68 68 CD 10_1101-2021_01_06_425584 34 19 for for IN 10_1101-2021_01_06_425584 34 20 48 48 CD 10_1101-2021_01_06_425584 34 21 h h NNS 10_1101-2021_01_06_425584 34 22 ( ( -LRB- 10_1101-2021_01_06_425584 34 23 12 12 CD 10_1101-2021_01_06_425584 34 24 ) ) -RRB- 10_1101-2021_01_06_425584 34 25 . . . 10_1101-2021_01_06_425584 35 1 However however RB 10_1101-2021_01_06_425584 35 2 , , , 10_1101-2021_01_06_425584 35 3 a a DT 10_1101-2021_01_06_425584 35 4 72 72 CD 10_1101-2021_01_06_425584 35 5 h h NN 10_1101-2021_01_06_425584 35 6 study study NN 10_1101-2021_01_06_425584 35 7 documented document VBD 10_1101-2021_01_06_425584 35 8 an an DT 10_1101-2021_01_06_425584 35 9 increased increase VBN 10_1101-2021_01_06_425584 35 10 in in IN 10_1101-2021_01_06_425584 35 11 pro pro JJ 10_1101-2021_01_06_425584 35 12 - - JJ 10_1101-2021_01_06_425584 35 13 inflammatory inflammatory JJ 10_1101-2021_01_06_425584 35 14 cytokines cytokine NNS 10_1101-2021_01_06_425584 35 15 ( ( -LRB- 10_1101-2021_01_06_425584 35 16 13 13 CD 10_1101-2021_01_06_425584 35 17 ) ) -RRB- 10_1101-2021_01_06_425584 35 18 69 69 CD 10_1101-2021_01_06_425584 35 19 and and CC 10_1101-2021_01_06_425584 35 20 oxidative oxidative JJ 10_1101-2021_01_06_425584 35 21 stress stress NN 10_1101-2021_01_06_425584 35 22 in in IN 10_1101-2021_01_06_425584 35 23 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 35 24 ( ( -LRB- 10_1101-2021_01_06_425584 35 25 14 14 CD 10_1101-2021_01_06_425584 35 26 ) ) -RRB- 10_1101-2021_01_06_425584 35 27 . . . 10_1101-2021_01_06_425584 36 1 The the DT 10_1101-2021_01_06_425584 36 2 long long JJ 10_1101-2021_01_06_425584 36 3 - - HYPH 10_1101-2021_01_06_425584 36 4 term term NN 10_1101-2021_01_06_425584 36 5 ( ( -LRB- 10_1101-2021_01_06_425584 36 6 > > NFP 10_1101-2021_01_06_425584 36 7 72 72 CD 10_1101-2021_01_06_425584 36 8 h h NNP 10_1101-2021_01_06_425584 36 9 ) ) -RRB- 10_1101-2021_01_06_425584 36 10 effect effect NN 10_1101-2021_01_06_425584 36 11 of of IN 10_1101-2021_01_06_425584 36 12 HG HG NNP 10_1101-2021_01_06_425584 36 13 in in IN 10_1101-2021_01_06_425584 36 14 CAEC caec NN 10_1101-2021_01_06_425584 36 15 has have VBZ 10_1101-2021_01_06_425584 36 16 not not RB 10_1101-2021_01_06_425584 36 17 been be VBN 10_1101-2021_01_06_425584 36 18 70 70 CD 10_1101-2021_01_06_425584 36 19 as as IN 10_1101-2021_01_06_425584 36 20 extensively extensively RB 10_1101-2021_01_06_425584 36 21 documented document VBN 10_1101-2021_01_06_425584 36 22 compared compare VBN 10_1101-2021_01_06_425584 36 23 to to IN 10_1101-2021_01_06_425584 36 24 other other JJ 10_1101-2021_01_06_425584 36 25 endothelial endothelial JJ 10_1101-2021_01_06_425584 36 26 cell cell NN 10_1101-2021_01_06_425584 36 27 types type NNS 10_1101-2021_01_06_425584 36 28 . . . 10_1101-2021_01_06_425584 37 1 Characterizing characterize VBG 10_1101-2021_01_06_425584 37 2 the the DT 10_1101-2021_01_06_425584 37 3 effect effect NN 10_1101-2021_01_06_425584 37 4 of of IN 10_1101-2021_01_06_425584 37 5 71 71 CD 10_1101-2021_01_06_425584 37 6 HG HG NNP 10_1101-2021_01_06_425584 37 7 on on IN 10_1101-2021_01_06_425584 37 8 CAEC CAEC NNP 10_1101-2021_01_06_425584 37 9 may may MD 10_1101-2021_01_06_425584 37 10 allow allow VB 10_1101-2021_01_06_425584 37 11 us -PRON- PRP 10_1101-2021_01_06_425584 37 12 to to TO 10_1101-2021_01_06_425584 37 13 identify identify VB 10_1101-2021_01_06_425584 37 14 key key JJ 10_1101-2021_01_06_425584 37 15 signaling signal VBG 10_1101-2021_01_06_425584 37 16 pathways pathway NNS 10_1101-2021_01_06_425584 37 17 ( ( -LRB- 10_1101-2021_01_06_425584 37 18 or or CC 10_1101-2021_01_06_425584 37 19 specific specific JJ 10_1101-2021_01_06_425584 37 20 biomolecules biomolecule NNS 10_1101-2021_01_06_425584 37 21 ) ) -RRB- 10_1101-2021_01_06_425584 37 22 72 72 CD 10_1101-2021_01_06_425584 37 23 associated associate VBN 10_1101-2021_01_06_425584 37 24 with with IN 10_1101-2021_01_06_425584 37 25 the the DT 10_1101-2021_01_06_425584 37 26 development development NN 10_1101-2021_01_06_425584 37 27 of of IN 10_1101-2021_01_06_425584 37 28 endothelial endothelial JJ 10_1101-2021_01_06_425584 37 29 dysfunction dysfunction NN 10_1101-2021_01_06_425584 37 30 and and CC 10_1101-2021_01_06_425584 37 31 cardiac cardiac JJ 10_1101-2021_01_06_425584 37 32 pathologies pathology NNS 10_1101-2021_01_06_425584 37 33 . . . 10_1101-2021_01_06_425584 38 1 73 73 CD 10_1101-2021_01_06_425584 38 2 Here here RB 10_1101-2021_01_06_425584 38 3 , , , 10_1101-2021_01_06_425584 38 4 liquid liquid JJ 10_1101-2021_01_06_425584 38 5 chromatography chromatography NN 10_1101-2021_01_06_425584 38 6 coupled couple VBN 10_1101-2021_01_06_425584 38 7 to to IN 10_1101-2021_01_06_425584 38 8 mass mass NNP 10_1101-2021_01_06_425584 38 9 spectrometry spectrometry NNP 10_1101-2021_01_06_425584 38 10 ( ( -LRB- 10_1101-2021_01_06_425584 38 11 LC LC NNP 10_1101-2021_01_06_425584 38 12 - - HYPH 10_1101-2021_01_06_425584 38 13 MS2)-based MS2)-based NNP 10_1101-2021_01_06_425584 38 14 untargeted untargeted JJ 10_1101-2021_01_06_425584 38 15 74 74 CD 10_1101-2021_01_06_425584 38 16 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 38 17 and and CC 10_1101-2021_01_06_425584 38 18 SWATH SWATH NNP 10_1101-2021_01_06_425584 38 19 - - HYPH 10_1101-2021_01_06_425584 38 20 based base VBN 10_1101-2021_01_06_425584 38 21 quantitative quantitative JJ 10_1101-2021_01_06_425584 38 22 proteomics proteomic NNS 10_1101-2021_01_06_425584 38 23 data datum NNS 10_1101-2021_01_06_425584 38 24 , , , 10_1101-2021_01_06_425584 38 25 as as RB 10_1101-2021_01_06_425584 38 26 well well RB 10_1101-2021_01_06_425584 38 27 as as IN 10_1101-2021_01_06_425584 38 28 bio- bio- NN 10_1101-2021_01_06_425584 38 29 and and CC 10_1101-2021_01_06_425584 38 30 chemo-75 chemo-75 NN 10_1101-2021_01_06_425584 38 31 informatics informatic NNS 10_1101-2021_01_06_425584 38 32 were be VBD 10_1101-2021_01_06_425584 38 33 used use VBN 10_1101-2021_01_06_425584 38 34 to to TO 10_1101-2021_01_06_425584 38 35 characterize characterize VB 10_1101-2021_01_06_425584 38 36 the the DT 10_1101-2021_01_06_425584 38 37 molecular molecular JJ 10_1101-2021_01_06_425584 38 38 perturbations perturbation NNS 10_1101-2021_01_06_425584 38 39 occurring occur VBG 10_1101-2021_01_06_425584 38 40 in in IN 10_1101-2021_01_06_425584 38 41 Bovine Bovine NNP 10_1101-2021_01_06_425584 38 42 Coronary Coronary NNP 10_1101-2021_01_06_425584 38 43 76 76 CD 10_1101-2021_01_06_425584 38 44 Artery Artery NNP 10_1101-2021_01_06_425584 38 45 Endothelial Endothelial NNP 10_1101-2021_01_06_425584 38 46 Cells Cells NNPS 10_1101-2021_01_06_425584 38 47 ( ( -LRB- 10_1101-2021_01_06_425584 38 48 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 38 49 ) ) -RRB- 10_1101-2021_01_06_425584 38 50 under under IN 10_1101-2021_01_06_425584 38 51 a a DT 10_1101-2021_01_06_425584 38 52 prolonged prolong VBN 10_1101-2021_01_06_425584 38 53 diabetic diabetic JJ 10_1101-2021_01_06_425584 38 54 environment environment NN 10_1101-2021_01_06_425584 38 55 . . . 10_1101-2021_01_06_425584 39 1 77 77 CD 10_1101-2021_01_06_425584 39 2 78 78 CD 10_1101-2021_01_06_425584 39 3 2 2 CD 10_1101-2021_01_06_425584 39 4 . . . 10_1101-2021_01_06_425584 40 1 Methods method NNS 10_1101-2021_01_06_425584 40 2 79 79 CD 10_1101-2021_01_06_425584 40 3 2.1 2.1 CD 10_1101-2021_01_06_425584 40 4 Chemical chemical NN 10_1101-2021_01_06_425584 40 5 and and CC 10_1101-2021_01_06_425584 40 6 reagents reagent NNS 10_1101-2021_01_06_425584 40 7 80 80 CD 10_1101-2021_01_06_425584 40 8 Recombinant recombinant JJ 10_1101-2021_01_06_425584 40 9 human human JJ 10_1101-2021_01_06_425584 40 10 insulin insulin NN 10_1101-2021_01_06_425584 40 11 was be VBD 10_1101-2021_01_06_425584 40 12 purchased purchase VBN 10_1101-2021_01_06_425584 40 13 from from IN 10_1101-2021_01_06_425584 40 14 Sigma Sigma NNP 10_1101-2021_01_06_425584 40 15 Aldrich Aldrich NNP 10_1101-2021_01_06_425584 40 16 ( ( -LRB- 10_1101-2021_01_06_425584 40 17 St. St. NNP 10_1101-2021_01_06_425584 40 18 Louis Louis NNP 10_1101-2021_01_06_425584 40 19 , , , 10_1101-2021_01_06_425584 40 20 MO MO NNP 10_1101-2021_01_06_425584 40 21 , , , 10_1101-2021_01_06_425584 40 22 USA USA NNP 10_1101-2021_01_06_425584 40 23 ) ) -RRB- 10_1101-2021_01_06_425584 40 24 . . . 10_1101-2021_01_06_425584 41 1 Antibiotic-81 Antibiotic-81 NNP 10_1101-2021_01_06_425584 41 2 antimitotic antimitotic JJ 10_1101-2021_01_06_425584 41 3 solution solution NN 10_1101-2021_01_06_425584 41 4 , , , 10_1101-2021_01_06_425584 41 5 trypsin trypsin NNP 10_1101-2021_01_06_425584 41 6 - - HYPH 10_1101-2021_01_06_425584 41 7 EDTA EDTA NNP 10_1101-2021_01_06_425584 41 8 solution solution NN 10_1101-2021_01_06_425584 41 9 0.25 0.25 CD 10_1101-2021_01_06_425584 41 10 % % NN 10_1101-2021_01_06_425584 41 11 , , , 10_1101-2021_01_06_425584 41 12 Hank Hank NNP 10_1101-2021_01_06_425584 41 13 ’s ’s POS 10_1101-2021_01_06_425584 41 14 Balanced Balanced NNP 10_1101-2021_01_06_425584 41 15 Salt Salt NNP 10_1101-2021_01_06_425584 41 16 Solution Solution NNP 10_1101-2021_01_06_425584 41 17 ( ( -LRB- 10_1101-2021_01_06_425584 41 18 HBSS HBSS NNP 10_1101-2021_01_06_425584 41 19 ) ) -RRB- 10_1101-2021_01_06_425584 41 20 without without IN 10_1101-2021_01_06_425584 41 21 82 82 CD 10_1101-2021_01_06_425584 41 22 .CC .CC : 10_1101-2021_01_06_425584 41 23 - - HYPH 10_1101-2021_01_06_425584 41 24 BY by IN 10_1101-2021_01_06_425584 41 25 - - HYPH 10_1101-2021_01_06_425584 41 26 NC NC NNP 10_1101-2021_01_06_425584 41 27 - - HYPH 10_1101-2021_01_06_425584 41 28 ND ND NNP 10_1101-2021_01_06_425584 41 29 4.0 4.0 CD 10_1101-2021_01_06_425584 41 30 International International NNP 10_1101-2021_01_06_425584 41 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 41 32 under under IN 10_1101-2021_01_06_425584 41 33 a a DT 10_1101-2021_01_06_425584 41 34 ( ( -LRB- 10_1101-2021_01_06_425584 41 35 which which WDT 10_1101-2021_01_06_425584 41 36 was be VBD 10_1101-2021_01_06_425584 41 37 not not RB 10_1101-2021_01_06_425584 41 38 certified certify VBN 10_1101-2021_01_06_425584 41 39 by by IN 10_1101-2021_01_06_425584 41 40 peer peer NN 10_1101-2021_01_06_425584 41 41 review review NN 10_1101-2021_01_06_425584 41 42 ) ) -RRB- 10_1101-2021_01_06_425584 41 43 is be VBZ 10_1101-2021_01_06_425584 41 44 the the DT 10_1101-2021_01_06_425584 41 45 author author NN 10_1101-2021_01_06_425584 41 46 / / SYM 10_1101-2021_01_06_425584 41 47 funder funder NN 10_1101-2021_01_06_425584 41 48 , , , 10_1101-2021_01_06_425584 41 49 who who WP 10_1101-2021_01_06_425584 41 50 has have VBZ 10_1101-2021_01_06_425584 41 51 granted grant VBN 10_1101-2021_01_06_425584 41 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 41 53 a a DT 10_1101-2021_01_06_425584 41 54 license license NN 10_1101-2021_01_06_425584 41 55 to to TO 10_1101-2021_01_06_425584 41 56 display display VB 10_1101-2021_01_06_425584 41 57 the the DT 10_1101-2021_01_06_425584 41 58 preprint preprint NN 10_1101-2021_01_06_425584 41 59 in in IN 10_1101-2021_01_06_425584 41 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 41 61 . . . 10_1101-2021_01_06_425584 42 1 It -PRON- PRP 10_1101-2021_01_06_425584 42 2 is be VBZ 10_1101-2021_01_06_425584 42 3 made make VBN 10_1101-2021_01_06_425584 42 4 The the DT 10_1101-2021_01_06_425584 42 5 copyright copyright NN 10_1101-2021_01_06_425584 42 6 holder holder NN 10_1101-2021_01_06_425584 42 7 for for IN 10_1101-2021_01_06_425584 42 8 this this DT 10_1101-2021_01_06_425584 42 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 42 10 version version NN 10_1101-2021_01_06_425584 42 11 posted post VBD 10_1101-2021_01_06_425584 42 12 January January NNP 10_1101-2021_01_06_425584 42 13 8 8 CD 10_1101-2021_01_06_425584 42 14 , , , 10_1101-2021_01_06_425584 42 15 2021 2021 CD 10_1101-2021_01_06_425584 42 16 . . . 10_1101-2021_01_06_425584 42 17 ; ; : 10_1101-2021_01_06_425584 42 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 42 19 : : : 10_1101-2021_01_06_425584 42 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 42 21 preprint preprint NN 10_1101-2021_01_06_425584 42 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 42 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 42 24 4 4 CD 10_1101-2021_01_06_425584 42 25 phenol phenol NN 10_1101-2021_01_06_425584 42 26 red red NN 10_1101-2021_01_06_425584 42 27 , , , 10_1101-2021_01_06_425584 42 28 Dulbecco Dulbecco NNP 10_1101-2021_01_06_425584 42 29 ’s ’s POS 10_1101-2021_01_06_425584 42 30 Modified Modified NNP 10_1101-2021_01_06_425584 42 31 Eagle Eagle NNP 10_1101-2021_01_06_425584 42 32 ’s ’s POS 10_1101-2021_01_06_425584 42 33 Media Media NNP 10_1101-2021_01_06_425584 42 34 ( ( -LRB- 10_1101-2021_01_06_425584 42 35 DMEM DMEM NNP 10_1101-2021_01_06_425584 42 36 ) ) -RRB- 10_1101-2021_01_06_425584 42 37 with with IN 10_1101-2021_01_06_425584 42 38 glutamine glutamine NN 10_1101-2021_01_06_425584 42 39 , , , 10_1101-2021_01_06_425584 42 40 Fetal Fetal NNP 10_1101-2021_01_06_425584 42 41 Bovine Bovine NNP 10_1101-2021_01_06_425584 42 42 Serum Serum NNP 10_1101-2021_01_06_425584 42 43 83 83 CD 10_1101-2021_01_06_425584 42 44 ( ( -LRB- 10_1101-2021_01_06_425584 42 45 FBS FBS NNP 10_1101-2021_01_06_425584 42 46 ) ) -RRB- 10_1101-2021_01_06_425584 42 47 , , , 10_1101-2021_01_06_425584 42 48 Hoechst Hoechst NNP 10_1101-2021_01_06_425584 42 49 33258 33258 CD 10_1101-2021_01_06_425584 42 50 , , , 10_1101-2021_01_06_425584 42 51 Pentahydrate Pentahydrate NNP 10_1101-2021_01_06_425584 42 52 ( ( -LRB- 10_1101-2021_01_06_425584 42 53 bis bis JJ 10_1101-2021_01_06_425584 42 54 - - HYPH 10_1101-2021_01_06_425584 42 55 Benzimide)-FluoroPure Benzimide)-FluoroPure NNP 10_1101-2021_01_06_425584 42 56 ™ ™ NN 10_1101-2021_01_06_425584 42 57 , , , 10_1101-2021_01_06_425584 42 58 and and CC 10_1101-2021_01_06_425584 42 59 methanol methanol NN 10_1101-2021_01_06_425584 42 60 - - HYPH 10_1101-2021_01_06_425584 42 61 free free JJ 10_1101-2021_01_06_425584 42 62 84 84 CD 10_1101-2021_01_06_425584 42 63 formaldehyde formaldehyde NN 10_1101-2021_01_06_425584 42 64 ( ( -LRB- 10_1101-2021_01_06_425584 42 65 16 16 CD 10_1101-2021_01_06_425584 42 66 % % NN 10_1101-2021_01_06_425584 42 67 solution solution NN 10_1101-2021_01_06_425584 42 68 ) ) -RRB- 10_1101-2021_01_06_425584 42 69 were be VBD 10_1101-2021_01_06_425584 42 70 obtained obtain VBN 10_1101-2021_01_06_425584 42 71 from from IN 10_1101-2021_01_06_425584 42 72 Thermo Thermo NNP 10_1101-2021_01_06_425584 42 73 Fisher Fisher NNP 10_1101-2021_01_06_425584 42 74 Scientific Scientific NNP 10_1101-2021_01_06_425584 42 75 ( ( -LRB- 10_1101-2021_01_06_425584 42 76 Waltham Waltham NNP 10_1101-2021_01_06_425584 42 77 , , , 10_1101-2021_01_06_425584 42 78 MA MA NNP 10_1101-2021_01_06_425584 42 79 , , , 10_1101-2021_01_06_425584 42 80 USA USA NNP 10_1101-2021_01_06_425584 42 81 ) ) -RRB- 10_1101-2021_01_06_425584 42 82 . . . 10_1101-2021_01_06_425584 43 1 85 85 CD 10_1101-2021_01_06_425584 43 2 Methanol Methanol NNP 10_1101-2021_01_06_425584 43 3 , , , 10_1101-2021_01_06_425584 43 4 Acetonitrile Acetonitrile NNP 10_1101-2021_01_06_425584 43 5 , , , 10_1101-2021_01_06_425584 43 6 and and CC 10_1101-2021_01_06_425584 43 7 water water NN 10_1101-2021_01_06_425584 43 8 were be VBD 10_1101-2021_01_06_425584 43 9 Optima Optima NNP 10_1101-2021_01_06_425584 43 10 ™ ™ CD 10_1101-2021_01_06_425584 43 11 LC LC NNP 10_1101-2021_01_06_425584 43 12 - - HYPH 10_1101-2021_01_06_425584 43 13 MS MS NNP 10_1101-2021_01_06_425584 43 14 Grade Grade NNP 10_1101-2021_01_06_425584 43 15 and and CC 10_1101-2021_01_06_425584 43 16 obtained obtain VBN 10_1101-2021_01_06_425584 43 17 from from IN 10_1101-2021_01_06_425584 43 18 Fisher Fisher NNP 10_1101-2021_01_06_425584 43 19 86 86 CD 10_1101-2021_01_06_425584 43 20 Scientific Scientific NNP 10_1101-2021_01_06_425584 43 21 ( ( -LRB- 10_1101-2021_01_06_425584 43 22 Hampton Hampton NNP 10_1101-2021_01_06_425584 43 23 , , , 10_1101-2021_01_06_425584 43 24 NH NH NNP 10_1101-2021_01_06_425584 43 25 , , , 10_1101-2021_01_06_425584 43 26 USA USA NNP 10_1101-2021_01_06_425584 43 27 ) ) -RRB- 10_1101-2021_01_06_425584 43 28 . . . 10_1101-2021_01_06_425584 44 1 Ethanol ethanol NN 10_1101-2021_01_06_425584 44 2 LiChrosolv LiChrosolv NNP 10_1101-2021_01_06_425584 44 3 ® ® NNP 10_1101-2021_01_06_425584 44 4 Grade Grade NNP 10_1101-2021_01_06_425584 44 5 was be VBD 10_1101-2021_01_06_425584 44 6 obtained obtain VBN 10_1101-2021_01_06_425584 44 7 from from IN 10_1101-2021_01_06_425584 44 8 Merck Merck NNP 10_1101-2021_01_06_425584 44 9 KGaA KGaA NNP 10_1101-2021_01_06_425584 44 10 87 87 CD 10_1101-2021_01_06_425584 44 11 ( ( -LRB- 10_1101-2021_01_06_425584 44 12 Darmstadt Darmstadt NNP 10_1101-2021_01_06_425584 44 13 , , , 10_1101-2021_01_06_425584 44 14 Germany Germany NNP 10_1101-2021_01_06_425584 44 15 ) ) -RRB- 10_1101-2021_01_06_425584 44 16 . . . 10_1101-2021_01_06_425584 45 1 Rabbit rabbit NN 10_1101-2021_01_06_425584 45 2 anti anti JJ 10_1101-2021_01_06_425584 45 3 - - JJ 10_1101-2021_01_06_425584 45 4 Von Von NNP 10_1101-2021_01_06_425584 45 5 Willebrand Willebrand NNP 10_1101-2021_01_06_425584 45 6 factor factor NN 10_1101-2021_01_06_425584 45 7 ( ( -LRB- 10_1101-2021_01_06_425584 45 8 vWf vWf NNS 10_1101-2021_01_06_425584 45 9 ) ) -RRB- 10_1101-2021_01_06_425584 45 10 antibody antibody NN 10_1101-2021_01_06_425584 45 11 and and CC 10_1101-2021_01_06_425584 45 12 goat goat NN 10_1101-2021_01_06_425584 45 13 anti anti JJ 10_1101-2021_01_06_425584 45 14 - - JJ 10_1101-2021_01_06_425584 45 15 rabbit rabbit JJ 10_1101-2021_01_06_425584 45 16 IgG IgG NNP 10_1101-2021_01_06_425584 45 17 88 88 CD 10_1101-2021_01_06_425584 45 18 conjugated conjugate VBD 10_1101-2021_01_06_425584 45 19 to to IN 10_1101-2021_01_06_425584 45 20 Alexa Alexa NNP 10_1101-2021_01_06_425584 45 21 Fluor Fluor NNP 10_1101-2021_01_06_425584 45 22 488 488 CD 10_1101-2021_01_06_425584 45 23 were be VBD 10_1101-2021_01_06_425584 45 24 obtained obtain VBN 10_1101-2021_01_06_425584 45 25 from from IN 10_1101-2021_01_06_425584 45 26 Abcam Abcam NNP 10_1101-2021_01_06_425584 45 27 ( ( -LRB- 10_1101-2021_01_06_425584 45 28 Cambridge Cambridge NNP 10_1101-2021_01_06_425584 45 29 , , , 10_1101-2021_01_06_425584 45 30 MA MA NNP 10_1101-2021_01_06_425584 45 31 , , , 10_1101-2021_01_06_425584 45 32 USA USA NNP 10_1101-2021_01_06_425584 45 33 ) ) -RRB- 10_1101-2021_01_06_425584 45 34 . . . 10_1101-2021_01_06_425584 46 1 89 89 CD 10_1101-2021_01_06_425584 46 2 90 90 CD 10_1101-2021_01_06_425584 46 3 2.2 2.2 CD 10_1101-2021_01_06_425584 46 4 Cell cell NN 10_1101-2021_01_06_425584 46 5 culture culture NN 10_1101-2021_01_06_425584 46 6 91 91 CD 10_1101-2021_01_06_425584 46 7 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 46 8 were be VBD 10_1101-2021_01_06_425584 46 9 purchased purchase VBN 10_1101-2021_01_06_425584 46 10 from from IN 10_1101-2021_01_06_425584 46 11 Cell Cell NNP 10_1101-2021_01_06_425584 46 12 applications application NNS 10_1101-2021_01_06_425584 46 13 , , , 10_1101-2021_01_06_425584 46 14 Inc. Inc. NNP 10_1101-2021_01_06_425584 46 15 ( ( -LRB- 10_1101-2021_01_06_425584 46 16 San San NNP 10_1101-2021_01_06_425584 46 17 Diego Diego NNP 10_1101-2021_01_06_425584 46 18 , , , 10_1101-2021_01_06_425584 46 19 CA CA NNP 10_1101-2021_01_06_425584 46 20 , , , 10_1101-2021_01_06_425584 46 21 USA USA NNP 10_1101-2021_01_06_425584 46 22 ) ) -RRB- 10_1101-2021_01_06_425584 46 23 and and CC 10_1101-2021_01_06_425584 46 24 grown grow VBN 10_1101-2021_01_06_425584 46 25 as as IN 10_1101-2021_01_06_425584 46 26 92 92 CD 10_1101-2021_01_06_425584 46 27 previously previously RB 10_1101-2021_01_06_425584 46 28 described describe VBN 10_1101-2021_01_06_425584 46 29 ( ( -LRB- 10_1101-2021_01_06_425584 46 30 15 15 CD 10_1101-2021_01_06_425584 46 31 ) ) -RRB- 10_1101-2021_01_06_425584 46 32 . . . 10_1101-2021_01_06_425584 47 1 In in IN 10_1101-2021_01_06_425584 47 2 brief brief JJ 10_1101-2021_01_06_425584 47 3 , , , 10_1101-2021_01_06_425584 47 4 cells cell NNS 10_1101-2021_01_06_425584 47 5 were be VBD 10_1101-2021_01_06_425584 47 6 grown grow VBN 10_1101-2021_01_06_425584 47 7 with with IN 10_1101-2021_01_06_425584 47 8 DMEM DMEM NNP 10_1101-2021_01_06_425584 47 9 ( ( -LRB- 10_1101-2021_01_06_425584 47 10 5.5 5.5 CD 10_1101-2021_01_06_425584 47 11 mmol mmol NN 10_1101-2021_01_06_425584 47 12 / / SYM 10_1101-2021_01_06_425584 47 13 L L NNP 10_1101-2021_01_06_425584 47 14 glucose glucose NN 10_1101-2021_01_06_425584 47 15 , , , 10_1101-2021_01_06_425584 47 16 93 93 CD 10_1101-2021_01_06_425584 47 17 supplemented supplement VBN 10_1101-2021_01_06_425584 47 18 with with IN 10_1101-2021_01_06_425584 47 19 10 10 CD 10_1101-2021_01_06_425584 47 20 % % NN 10_1101-2021_01_06_425584 47 21 FBS FBS NNP 10_1101-2021_01_06_425584 47 22 and and CC 10_1101-2021_01_06_425584 47 23 1 1 CD 10_1101-2021_01_06_425584 47 24 % % NN 10_1101-2021_01_06_425584 47 25 antibiotic antibiotic JJ 10_1101-2021_01_06_425584 47 26 - - HYPH 10_1101-2021_01_06_425584 47 27 antimitotic antimitotic JJ 10_1101-2021_01_06_425584 47 28 solution solution NN 10_1101-2021_01_06_425584 47 29 ) ) -RRB- 10_1101-2021_01_06_425584 47 30 at at IN 10_1101-2021_01_06_425584 47 31 37 37 CD 10_1101-2021_01_06_425584 47 32 oC oC NNP 10_1101-2021_01_06_425584 47 33 in in IN 10_1101-2021_01_06_425584 47 34 an an DT 10_1101-2021_01_06_425584 47 35 incubator incubator NN 10_1101-2021_01_06_425584 47 36 with with IN 10_1101-2021_01_06_425584 47 37 94 94 CD 10_1101-2021_01_06_425584 47 38 a a DT 10_1101-2021_01_06_425584 47 39 humidified humidified JJ 10_1101-2021_01_06_425584 47 40 atmosphere atmosphere NN 10_1101-2021_01_06_425584 47 41 of of IN 10_1101-2021_01_06_425584 47 42 5 5 CD 10_1101-2021_01_06_425584 47 43 % % NN 10_1101-2021_01_06_425584 47 44 CO2 CO2 NNP 10_1101-2021_01_06_425584 47 45 . . . 10_1101-2021_01_06_425584 48 1 Before before IN 10_1101-2021_01_06_425584 48 2 experiments experiment NNS 10_1101-2021_01_06_425584 48 3 , , , 10_1101-2021_01_06_425584 48 4 cells cell NNS 10_1101-2021_01_06_425584 48 5 were be VBD 10_1101-2021_01_06_425584 48 6 switched switch VBN 10_1101-2021_01_06_425584 48 7 to to IN 10_1101-2021_01_06_425584 48 8 DMEM DMEM NNP 10_1101-2021_01_06_425584 48 9 with with IN 10_1101-2021_01_06_425584 48 10 1 1 CD 10_1101-2021_01_06_425584 48 11 % % NN 10_1101-2021_01_06_425584 48 12 95 95 CD 10_1101-2021_01_06_425584 48 13 FBS fbs NN 10_1101-2021_01_06_425584 48 14 for for IN 10_1101-2021_01_06_425584 48 15 12 12 CD 10_1101-2021_01_06_425584 48 16 h h NN 10_1101-2021_01_06_425584 48 17 to to TO 10_1101-2021_01_06_425584 48 18 maintain maintain VB 10_1101-2021_01_06_425584 48 19 the the DT 10_1101-2021_01_06_425584 48 20 cells cell NNS 10_1101-2021_01_06_425584 48 21 under under IN 10_1101-2021_01_06_425584 48 22 a a DT 10_1101-2021_01_06_425584 48 23 quiescent quiescent JJ 10_1101-2021_01_06_425584 48 24 state state NN 10_1101-2021_01_06_425584 48 25 . . . 10_1101-2021_01_06_425584 49 1 The the DT 10_1101-2021_01_06_425584 49 2 model model NN 10_1101-2021_01_06_425584 49 3 to to TO 10_1101-2021_01_06_425584 49 4 simulate simulate VB 10_1101-2021_01_06_425584 49 5 diabetes diabetes NN 10_1101-2021_01_06_425584 49 6 is be VBZ 10_1101-2021_01_06_425584 49 7 96 96 CD 10_1101-2021_01_06_425584 49 8 described describe VBN 10_1101-2021_01_06_425584 49 9 in in IN 10_1101-2021_01_06_425584 49 10 ( ( -LRB- 10_1101-2021_01_06_425584 49 11 15 15 CD 10_1101-2021_01_06_425584 49 12 ) ) -RRB- 10_1101-2021_01_06_425584 49 13 ( ( -LRB- 10_1101-2021_01_06_425584 49 14 Figure figure NN 10_1101-2021_01_06_425584 49 15 1 1 CD 10_1101-2021_01_06_425584 49 16 ) ) -RRB- 10_1101-2021_01_06_425584 49 17 . . . 10_1101-2021_01_06_425584 50 1 Endothelial endothelial JJ 10_1101-2021_01_06_425584 50 2 cells cell NNS 10_1101-2021_01_06_425584 50 3 were be VBD 10_1101-2021_01_06_425584 50 4 cultured culture VBN 10_1101-2021_01_06_425584 50 5 for for IN 10_1101-2021_01_06_425584 50 6 12 12 CD 10_1101-2021_01_06_425584 50 7 days day NNS 10_1101-2021_01_06_425584 50 8 to to TO 10_1101-2021_01_06_425584 50 9 determine determine VB 10_1101-2021_01_06_425584 50 10 the the DT 10_1101-2021_01_06_425584 50 11 chronic chronic JJ 10_1101-2021_01_06_425584 50 12 97 97 CD 10_1101-2021_01_06_425584 50 13 molecular molecular JJ 10_1101-2021_01_06_425584 50 14 perturbations perturbation NNS 10_1101-2021_01_06_425584 50 15 caused cause VBN 10_1101-2021_01_06_425584 50 16 by by IN 10_1101-2021_01_06_425584 50 17 simulated simulated JJ 10_1101-2021_01_06_425584 50 18 diabetes diabetes NN 10_1101-2021_01_06_425584 50 19 and and CC 10_1101-2021_01_06_425584 50 20 to to TO 10_1101-2021_01_06_425584 50 21 avoid avoid VB 10_1101-2021_01_06_425584 50 22 the the DT 10_1101-2021_01_06_425584 50 23 early early JJ 10_1101-2021_01_06_425584 50 24 ( ( -LRB- 10_1101-2021_01_06_425584 50 25 within within IN 10_1101-2021_01_06_425584 50 26 48 48 CD 10_1101-2021_01_06_425584 50 27 h h NN 10_1101-2021_01_06_425584 50 28 ) ) -RRB- 10_1101-2021_01_06_425584 50 29 cell cell NN 10_1101-2021_01_06_425584 50 30 98 98 CD 10_1101-2021_01_06_425584 50 31 proliferation proliferation NN 10_1101-2021_01_06_425584 50 32 effects effect NNS 10_1101-2021_01_06_425584 50 33 caused cause VBN 10_1101-2021_01_06_425584 50 34 by by IN 10_1101-2021_01_06_425584 50 35 HG HG NNP 10_1101-2021_01_06_425584 50 36 ( ( -LRB- 10_1101-2021_01_06_425584 50 37 10 10 CD 10_1101-2021_01_06_425584 50 38 , , , 10_1101-2021_01_06_425584 50 39 16 16 CD 10_1101-2021_01_06_425584 50 40 ) ) -RRB- 10_1101-2021_01_06_425584 50 41 . . . 10_1101-2021_01_06_425584 51 1 In in IN 10_1101-2021_01_06_425584 51 2 brief brief JJ 10_1101-2021_01_06_425584 51 3 , , , 10_1101-2021_01_06_425584 51 4 cells cell NNS 10_1101-2021_01_06_425584 51 5 were be VBD 10_1101-2021_01_06_425584 51 6 first first RB 10_1101-2021_01_06_425584 51 7 treated treat VBN 10_1101-2021_01_06_425584 51 8 with with IN 10_1101-2021_01_06_425584 51 9 100 100 CD 10_1101-2021_01_06_425584 51 10 nmol nmol JJ 10_1101-2021_01_06_425584 51 11 / / SYM 10_1101-2021_01_06_425584 51 12 L L NNP 10_1101-2021_01_06_425584 51 13 insulin insulin NN 10_1101-2021_01_06_425584 51 14 99 99 CD 10_1101-2021_01_06_425584 51 15 ( ( -LRB- 10_1101-2021_01_06_425584 51 16 high high JJ 10_1101-2021_01_06_425584 51 17 - - HYPH 10_1101-2021_01_06_425584 51 18 insulin insulin NN 10_1101-2021_01_06_425584 51 19 , , , 10_1101-2021_01_06_425584 51 20 HI HI NNP 10_1101-2021_01_06_425584 51 21 ) ) -RRB- 10_1101-2021_01_06_425584 51 22 in in IN 10_1101-2021_01_06_425584 51 23 normal normal JJ 10_1101-2021_01_06_425584 51 24 glucose glucose NN 10_1101-2021_01_06_425584 51 25 ( ( -LRB- 10_1101-2021_01_06_425584 51 26 NG NG NNP 10_1101-2021_01_06_425584 51 27 , , , 10_1101-2021_01_06_425584 51 28 5.5 5.5 CD 10_1101-2021_01_06_425584 51 29 mmol mmol NN 10_1101-2021_01_06_425584 51 30 / / SYM 10_1101-2021_01_06_425584 51 31 L l NN 10_1101-2021_01_06_425584 51 32 in in IN 10_1101-2021_01_06_425584 51 33 DMEM DMEM NNP 10_1101-2021_01_06_425584 51 34 ) ) -RRB- 10_1101-2021_01_06_425584 51 35 for for IN 10_1101-2021_01_06_425584 51 36 3 3 CD 10_1101-2021_01_06_425584 51 37 days day NNS 10_1101-2021_01_06_425584 51 38 ( ( -LRB- 10_1101-2021_01_06_425584 51 39 17 17 CD 10_1101-2021_01_06_425584 51 40 ) ) -RRB- 10_1101-2021_01_06_425584 51 41 and and CC 10_1101-2021_01_06_425584 51 42 then then RB 10_1101-2021_01_06_425584 51 43 100 100 CD 10_1101-2021_01_06_425584 51 44 maintained maintain VBN 10_1101-2021_01_06_425584 51 45 in in IN 10_1101-2021_01_06_425584 51 46 high high JJ 10_1101-2021_01_06_425584 51 47 - - HYPH 10_1101-2021_01_06_425584 51 48 glucose glucose NN 10_1101-2021_01_06_425584 51 49 ( ( -LRB- 10_1101-2021_01_06_425584 51 50 HG HG NNP 10_1101-2021_01_06_425584 51 51 , , , 10_1101-2021_01_06_425584 51 52 20 20 CD 10_1101-2021_01_06_425584 51 53 mmol mmol NN 10_1101-2021_01_06_425584 51 54 / / SYM 10_1101-2021_01_06_425584 51 55 L l NN 10_1101-2021_01_06_425584 51 56 in in IN 10_1101-2021_01_06_425584 51 57 DMEM DMEM NNP 10_1101-2021_01_06_425584 51 58 ) ) -RRB- 10_1101-2021_01_06_425584 51 59 and and CC 10_1101-2021_01_06_425584 51 60 constant constant JJ 10_1101-2021_01_06_425584 51 61 HI HI NNP 10_1101-2021_01_06_425584 51 62 for for IN 10_1101-2021_01_06_425584 51 63 9 9 CD 10_1101-2021_01_06_425584 51 64 days day NNS 10_1101-2021_01_06_425584 51 65 . . . 10_1101-2021_01_06_425584 52 1 This this DT 10_1101-2021_01_06_425584 52 2 sequential sequential JJ 10_1101-2021_01_06_425584 52 3 101 101 CD 10_1101-2021_01_06_425584 52 4 scheme scheme NN 10_1101-2021_01_06_425584 52 5 tried try VBD 10_1101-2021_01_06_425584 52 6 to to TO 10_1101-2021_01_06_425584 52 7 mimic mimic VB 10_1101-2021_01_06_425584 52 8 the the DT 10_1101-2021_01_06_425584 52 9 pathophysiological pathophysiological JJ 10_1101-2021_01_06_425584 52 10 conditions condition NNS 10_1101-2021_01_06_425584 52 11 that that WDT 10_1101-2021_01_06_425584 52 12 occur occur VBP 10_1101-2021_01_06_425584 52 13 in in IN 10_1101-2021_01_06_425584 52 14 T2DM t2dm NN 10_1101-2021_01_06_425584 52 15 patients patient NNS 10_1101-2021_01_06_425584 52 16 , , , 10_1101-2021_01_06_425584 52 17 wherein wherein WRB 10_1101-2021_01_06_425584 52 18 102 102 CD 10_1101-2021_01_06_425584 52 19 hyperinsulinemia hyperinsulinemia NN 10_1101-2021_01_06_425584 52 20 precedes precede NNS 10_1101-2021_01_06_425584 52 21 hyperglycemia hyperglycemia NNP 10_1101-2021_01_06_425584 52 22 ( ( -LRB- 10_1101-2021_01_06_425584 52 23 18 18 CD 10_1101-2021_01_06_425584 52 24 ) ) -RRB- 10_1101-2021_01_06_425584 52 25 . . . 10_1101-2021_01_06_425584 53 1 Cells cell NNS 10_1101-2021_01_06_425584 53 2 were be VBD 10_1101-2021_01_06_425584 53 3 used use VBN 10_1101-2021_01_06_425584 53 4 at at IN 10_1101-2021_01_06_425584 53 5 passages passage NNS 10_1101-2021_01_06_425584 53 6 between between IN 10_1101-2021_01_06_425584 53 7 6 6 CD 10_1101-2021_01_06_425584 53 8 to to TO 10_1101-2021_01_06_425584 53 9 12 12 CD 10_1101-2021_01_06_425584 53 10 . . . 10_1101-2021_01_06_425584 54 1 103 103 CD 10_1101-2021_01_06_425584 54 2 The the DT 10_1101-2021_01_06_425584 54 3 control control NN 10_1101-2021_01_06_425584 54 4 group group NN 10_1101-2021_01_06_425584 54 5 did do VBD 10_1101-2021_01_06_425584 54 6 not not RB 10_1101-2021_01_06_425584 54 7 receive receive VB 10_1101-2021_01_06_425584 54 8 HI HI NNP 10_1101-2021_01_06_425584 54 9 nor nor CC 10_1101-2021_01_06_425584 54 10 HG HG NNP 10_1101-2021_01_06_425584 54 11 treatment treatment NN 10_1101-2021_01_06_425584 54 12 . . . 10_1101-2021_01_06_425584 55 1 For for IN 10_1101-2021_01_06_425584 55 2 selected select VBN 10_1101-2021_01_06_425584 55 3 experiments experiment NNS 10_1101-2021_01_06_425584 55 4 ( ( -LRB- 10_1101-2021_01_06_425584 55 5 binucleation binucleation NNP 10_1101-2021_01_06_425584 55 6 104 104 CD 10_1101-2021_01_06_425584 55 7 analysis analysis NN 10_1101-2021_01_06_425584 55 8 ) ) -RRB- 10_1101-2021_01_06_425584 55 9 , , , 10_1101-2021_01_06_425584 55 10 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 55 11 ( ( -LRB- 10_1101-2021_01_06_425584 55 12 55 55 CD 10_1101-2021_01_06_425584 55 13 years year NNS 10_1101-2021_01_06_425584 55 14 old old JJ 10_1101-2021_01_06_425584 55 15 Caucasian caucasian JJ 10_1101-2021_01_06_425584 55 16 male male NN 10_1101-2021_01_06_425584 55 17 , , , 10_1101-2021_01_06_425584 55 18 history history NN 10_1101-2021_01_06_425584 55 19 of of IN 10_1101-2021_01_06_425584 55 20 T2DM T2DM NNP 10_1101-2021_01_06_425584 55 21 for for IN 10_1101-2021_01_06_425584 55 22 > > NN 10_1101-2021_01_06_425584 55 23 5 5 CD 10_1101-2021_01_06_425584 55 24 years year NNS 10_1101-2021_01_06_425584 55 25 ) ) -RRB- 10_1101-2021_01_06_425584 55 26 were be VBD 10_1101-2021_01_06_425584 55 27 purchased purchase VBN 10_1101-2021_01_06_425584 55 28 105 105 CD 10_1101-2021_01_06_425584 55 29 from from IN 10_1101-2021_01_06_425584 55 30 Cell Cell NNP 10_1101-2021_01_06_425584 55 31 Applications Applications NNP 10_1101-2021_01_06_425584 55 32 , , , 10_1101-2021_01_06_425584 55 33 Inc. Inc. NNP 10_1101-2021_01_06_425584 55 34 and and CC 10_1101-2021_01_06_425584 55 35 subjected subject VBN 10_1101-2021_01_06_425584 55 36 to to IN 10_1101-2021_01_06_425584 55 37 the the DT 10_1101-2021_01_06_425584 55 38 same same JJ 10_1101-2021_01_06_425584 55 39 conditions condition NNS 10_1101-2021_01_06_425584 55 40 as as IN 10_1101-2021_01_06_425584 55 41 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 55 42 but but CC 10_1101-2021_01_06_425584 55 43 using use VBG 10_1101-2021_01_06_425584 55 44 MesoEndo MesoEndo NNP 10_1101-2021_01_06_425584 55 45 106 106 CD 10_1101-2021_01_06_425584 55 46 Growth growth NN 10_1101-2021_01_06_425584 55 47 Medium medium NN 10_1101-2021_01_06_425584 55 48 ( ( -LRB- 10_1101-2021_01_06_425584 55 49 Cell Cell NNP 10_1101-2021_01_06_425584 55 50 Applications Applications NNP 10_1101-2021_01_06_425584 55 51 , , , 10_1101-2021_01_06_425584 55 52 Inc. Inc. NNP 10_1101-2021_01_06_425584 55 53 ) ) -RRB- 10_1101-2021_01_06_425584 55 54 to to TO 10_1101-2021_01_06_425584 55 55 induce induce VB 10_1101-2021_01_06_425584 55 56 proliferation proliferation NN 10_1101-2021_01_06_425584 55 57 . . . 10_1101-2021_01_06_425584 56 1 For for IN 10_1101-2021_01_06_425584 56 2 simulated simulated JJ 10_1101-2021_01_06_425584 56 3 diabetes diabete NNS 10_1101-2021_01_06_425584 56 4 , , , 10_1101-2021_01_06_425584 56 5 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 56 6 107 107 CD 10_1101-2021_01_06_425584 56 7 were be VBD 10_1101-2021_01_06_425584 56 8 treated treat VBN 10_1101-2021_01_06_425584 56 9 with with IN 10_1101-2021_01_06_425584 56 10 HI HI NNP 10_1101-2021_01_06_425584 56 11 and and CC 10_1101-2021_01_06_425584 56 12 HG HG NNP 10_1101-2021_01_06_425584 56 13 as as IN 10_1101-2021_01_06_425584 56 14 with with IN 10_1101-2021_01_06_425584 56 15 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 56 16 but but CC 10_1101-2021_01_06_425584 56 17 , , , 10_1101-2021_01_06_425584 56 18 MesoEndo MesoEndo NNP 10_1101-2021_01_06_425584 56 19 Growht Growht NNP 10_1101-2021_01_06_425584 56 20 Medium Medium NNP 10_1101-2021_01_06_425584 56 21 was be VBD 10_1101-2021_01_06_425584 56 22 used use VBN 10_1101-2021_01_06_425584 56 23 instead instead RB 10_1101-2021_01_06_425584 56 24 . . . 10_1101-2021_01_06_425584 57 1 108 108 CD 10_1101-2021_01_06_425584 57 2 For for IN 10_1101-2021_01_06_425584 57 3 consistency consistency NN 10_1101-2021_01_06_425584 57 4 , , , 10_1101-2021_01_06_425584 57 5 the the DT 10_1101-2021_01_06_425584 57 6 group group NN 10_1101-2021_01_06_425584 57 7 that that WDT 10_1101-2021_01_06_425584 57 8 underwent undergo VBD 10_1101-2021_01_06_425584 57 9 simulated simulated JJ 10_1101-2021_01_06_425584 57 10 diabetes diabetes NN 10_1101-2021_01_06_425584 57 11 ( ( -LRB- 10_1101-2021_01_06_425584 57 12 HG HG NNP 10_1101-2021_01_06_425584 57 13 + + CC 10_1101-2021_01_06_425584 57 14 HI HI NNP 10_1101-2021_01_06_425584 57 15 ) ) -RRB- 10_1101-2021_01_06_425584 57 16 will will MD 10_1101-2021_01_06_425584 57 17 be be VB 10_1101-2021_01_06_425584 57 18 referred refer VBN 10_1101-2021_01_06_425584 57 19 to to IN 10_1101-2021_01_06_425584 57 20 as as IN 10_1101-2021_01_06_425584 57 21 the the DT 10_1101-2021_01_06_425584 57 22 109 109 CD 10_1101-2021_01_06_425584 57 23 “ " `` 10_1101-2021_01_06_425584 57 24 experimental experimental JJ 10_1101-2021_01_06_425584 57 25 group group NN 10_1101-2021_01_06_425584 57 26 ” " '' 10_1101-2021_01_06_425584 57 27 . . . 10_1101-2021_01_06_425584 58 1 All all DT 10_1101-2021_01_06_425584 58 2 experiments experiment NNS 10_1101-2021_01_06_425584 58 3 were be VBD 10_1101-2021_01_06_425584 58 4 carried carry VBN 10_1101-2021_01_06_425584 58 5 out out RP 10_1101-2021_01_06_425584 58 6 in in IN 10_1101-2021_01_06_425584 58 7 triplicate triplicate NN 10_1101-2021_01_06_425584 58 8 . . . 10_1101-2021_01_06_425584 59 1 110 110 CD 10_1101-2021_01_06_425584 59 2 111 111 CD 10_1101-2021_01_06_425584 59 3 2.3 2.3 CD 10_1101-2021_01_06_425584 59 4 Immunofluorescence immunofluorescence NN 10_1101-2021_01_06_425584 59 5 112 112 CD 10_1101-2021_01_06_425584 59 6 As as RB 10_1101-2021_01_06_425584 59 7 previously previously RB 10_1101-2021_01_06_425584 59 8 described describe VBN 10_1101-2021_01_06_425584 59 9 ( ( -LRB- 10_1101-2021_01_06_425584 59 10 15 15 CD 10_1101-2021_01_06_425584 59 11 ) ) -RRB- 10_1101-2021_01_06_425584 59 12 , , , 10_1101-2021_01_06_425584 59 13 100,000 100,000 CD 10_1101-2021_01_06_425584 59 14 cells cell NNS 10_1101-2021_01_06_425584 59 15 per per IN 10_1101-2021_01_06_425584 59 16 well well RB 10_1101-2021_01_06_425584 59 17 were be VBD 10_1101-2021_01_06_425584 59 18 seeded seed VBN 10_1101-2021_01_06_425584 59 19 onto onto IN 10_1101-2021_01_06_425584 59 20 12-well 12-well CD 10_1101-2021_01_06_425584 59 21 plates plate NNS 10_1101-2021_01_06_425584 59 22 ( ( -LRB- 10_1101-2021_01_06_425584 59 23 Corning corn VBG 10_1101-2021_01_06_425584 59 24 ® ® NNPS 10_1101-2021_01_06_425584 59 25 113 113 CD 10_1101-2021_01_06_425584 59 26 CellBIND CellBIND NNP 10_1101-2021_01_06_425584 59 27 ® ® : 10_1101-2021_01_06_425584 59 28 ) ) -RRB- 10_1101-2021_01_06_425584 59 29 and and CC 10_1101-2021_01_06_425584 59 30 exposed expose VBN 10_1101-2021_01_06_425584 59 31 to to IN 10_1101-2021_01_06_425584 59 32 simulated simulate VBN 10_1101-2021_01_06_425584 59 33 diabetes diabete NNS 10_1101-2021_01_06_425584 59 34 . . . 10_1101-2021_01_06_425584 60 1 Thereafter thereafter RB 10_1101-2021_01_06_425584 60 2 , , , 10_1101-2021_01_06_425584 60 3 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 60 4 and and CC 10_1101-2021_01_06_425584 60 5 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 60 6 were be VBD 10_1101-2021_01_06_425584 60 7 washed wash VBN 10_1101-2021_01_06_425584 60 8 114 114 CD 10_1101-2021_01_06_425584 60 9 with with IN 10_1101-2021_01_06_425584 60 10 PBS PBS NNP 10_1101-2021_01_06_425584 60 11 to to TO 10_1101-2021_01_06_425584 60 12 remove remove VB 10_1101-2021_01_06_425584 60 13 dead dead JJ 10_1101-2021_01_06_425584 60 14 cells cell NNS 10_1101-2021_01_06_425584 60 15 and and CC 10_1101-2021_01_06_425584 60 16 debris debris NN 10_1101-2021_01_06_425584 60 17 . . . 10_1101-2021_01_06_425584 61 1 Cells cell NNS 10_1101-2021_01_06_425584 61 2 were be VBD 10_1101-2021_01_06_425584 61 3 fixed fix VBN 10_1101-2021_01_06_425584 61 4 , , , 10_1101-2021_01_06_425584 61 5 permeabilized permeabilize VBN 10_1101-2021_01_06_425584 61 6 , , , 10_1101-2021_01_06_425584 61 7 and and CC 10_1101-2021_01_06_425584 61 8 blocked block VBD 10_1101-2021_01_06_425584 61 9 as as IN 10_1101-2021_01_06_425584 61 10 115 115 CD 10_1101-2021_01_06_425584 61 11 described describe VBN 10_1101-2021_01_06_425584 61 12 before before IN 10_1101-2021_01_06_425584 61 13 ( ( -LRB- 10_1101-2021_01_06_425584 61 14 19 19 CD 10_1101-2021_01_06_425584 61 15 ) ) -RRB- 10_1101-2021_01_06_425584 61 16 . . . 10_1101-2021_01_06_425584 62 1 Cells cell NNS 10_1101-2021_01_06_425584 62 2 were be VBD 10_1101-2021_01_06_425584 62 3 then then RB 10_1101-2021_01_06_425584 62 4 incubated incubate VBN 10_1101-2021_01_06_425584 62 5 with with IN 10_1101-2021_01_06_425584 62 6 a a DT 10_1101-2021_01_06_425584 62 7 polyclonal polyclonal JJ 10_1101-2021_01_06_425584 62 8 antibody antibody NN 10_1101-2021_01_06_425584 62 9 against against IN 10_1101-2021_01_06_425584 62 10 the the DT 10_1101-2021_01_06_425584 62 11 vWf vWf NNP 10_1101-2021_01_06_425584 62 12 116 116 CD 10_1101-2021_01_06_425584 62 13 .CC .CC NFP 10_1101-2021_01_06_425584 62 14 - - HYPH 10_1101-2021_01_06_425584 62 15 BY by IN 10_1101-2021_01_06_425584 62 16 - - HYPH 10_1101-2021_01_06_425584 62 17 NC NC NNP 10_1101-2021_01_06_425584 62 18 - - HYPH 10_1101-2021_01_06_425584 62 19 ND ND NNP 10_1101-2021_01_06_425584 62 20 4.0 4.0 CD 10_1101-2021_01_06_425584 62 21 International International NNP 10_1101-2021_01_06_425584 62 22 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 62 23 under under IN 10_1101-2021_01_06_425584 62 24 a a DT 10_1101-2021_01_06_425584 62 25 ( ( -LRB- 10_1101-2021_01_06_425584 62 26 which which WDT 10_1101-2021_01_06_425584 62 27 was be VBD 10_1101-2021_01_06_425584 62 28 not not RB 10_1101-2021_01_06_425584 62 29 certified certify VBN 10_1101-2021_01_06_425584 62 30 by by IN 10_1101-2021_01_06_425584 62 31 peer peer NN 10_1101-2021_01_06_425584 62 32 review review NN 10_1101-2021_01_06_425584 62 33 ) ) -RRB- 10_1101-2021_01_06_425584 62 34 is be VBZ 10_1101-2021_01_06_425584 62 35 the the DT 10_1101-2021_01_06_425584 62 36 author author NN 10_1101-2021_01_06_425584 62 37 / / SYM 10_1101-2021_01_06_425584 62 38 funder funder NN 10_1101-2021_01_06_425584 62 39 , , , 10_1101-2021_01_06_425584 62 40 who who WP 10_1101-2021_01_06_425584 62 41 has have VBZ 10_1101-2021_01_06_425584 62 42 granted grant VBN 10_1101-2021_01_06_425584 62 43 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 62 44 a a DT 10_1101-2021_01_06_425584 62 45 license license NN 10_1101-2021_01_06_425584 62 46 to to TO 10_1101-2021_01_06_425584 62 47 display display VB 10_1101-2021_01_06_425584 62 48 the the DT 10_1101-2021_01_06_425584 62 49 preprint preprint NN 10_1101-2021_01_06_425584 62 50 in in IN 10_1101-2021_01_06_425584 62 51 perpetuity perpetuity NN 10_1101-2021_01_06_425584 62 52 . . . 10_1101-2021_01_06_425584 63 1 It -PRON- PRP 10_1101-2021_01_06_425584 63 2 is be VBZ 10_1101-2021_01_06_425584 63 3 made make VBN 10_1101-2021_01_06_425584 63 4 The the DT 10_1101-2021_01_06_425584 63 5 copyright copyright NN 10_1101-2021_01_06_425584 63 6 holder holder NN 10_1101-2021_01_06_425584 63 7 for for IN 10_1101-2021_01_06_425584 63 8 this this DT 10_1101-2021_01_06_425584 63 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 63 10 version version NN 10_1101-2021_01_06_425584 63 11 posted post VBD 10_1101-2021_01_06_425584 63 12 January January NNP 10_1101-2021_01_06_425584 63 13 8 8 CD 10_1101-2021_01_06_425584 63 14 , , , 10_1101-2021_01_06_425584 63 15 2021 2021 CD 10_1101-2021_01_06_425584 63 16 . . . 10_1101-2021_01_06_425584 63 17 ; ; : 10_1101-2021_01_06_425584 63 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 63 19 : : : 10_1101-2021_01_06_425584 63 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 63 21 preprint preprint NN 10_1101-2021_01_06_425584 63 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 63 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 63 24 5 5 CD 10_1101-2021_01_06_425584 63 25 ( ( -LRB- 10_1101-2021_01_06_425584 63 26 1:400 1:400 CD 10_1101-2021_01_06_425584 63 27 , , , 10_1101-2021_01_06_425584 63 28 3 3 CD 10_1101-2021_01_06_425584 63 29 % % NN 10_1101-2021_01_06_425584 63 30 BSA BSA NNP 10_1101-2021_01_06_425584 63 31 in in IN 10_1101-2021_01_06_425584 63 32 PBS PBS NNP 10_1101-2021_01_06_425584 63 33 ) ) -RRB- 10_1101-2021_01_06_425584 63 34 overnight overnight RB 10_1101-2021_01_06_425584 63 35 at at IN 10_1101-2021_01_06_425584 63 36 4oC 4oc CD 10_1101-2021_01_06_425584 63 37 and and CC 10_1101-2021_01_06_425584 63 38 thereafter thereafter RB 10_1101-2021_01_06_425584 63 39 washed wash VBD 10_1101-2021_01_06_425584 63 40 3x 3x CD 10_1101-2021_01_06_425584 63 41 with with IN 10_1101-2021_01_06_425584 63 42 PBS PBS NNP 10_1101-2021_01_06_425584 63 43 . . . 10_1101-2021_01_06_425584 64 1 Alexa Alexa NNP 10_1101-2021_01_06_425584 64 2 Fluor Fluor NNP 10_1101-2021_01_06_425584 64 3 488 488 CD 10_1101-2021_01_06_425584 64 4 - - SYM 10_1101-2021_01_06_425584 64 5 117 117 CD 10_1101-2021_01_06_425584 64 6 labeled label VBD 10_1101-2021_01_06_425584 64 7 anti anti JJ 10_1101-2021_01_06_425584 64 8 - - NN 10_1101-2021_01_06_425584 64 9 rabbit rabbit JJ 10_1101-2021_01_06_425584 64 10 ( ( -LRB- 10_1101-2021_01_06_425584 64 11 1:400 1:400 CD 10_1101-2021_01_06_425584 64 12 in in IN 10_1101-2021_01_06_425584 64 13 PBS PBS NNP 10_1101-2021_01_06_425584 64 14 ) ) -RRB- 10_1101-2021_01_06_425584 64 15 was be VBD 10_1101-2021_01_06_425584 64 16 then then RB 10_1101-2021_01_06_425584 64 17 used use VBN 10_1101-2021_01_06_425584 64 18 as as IN 10_1101-2021_01_06_425584 64 19 a a DT 10_1101-2021_01_06_425584 64 20 secondary secondary JJ 10_1101-2021_01_06_425584 64 21 antibody antibody NN 10_1101-2021_01_06_425584 64 22 for for IN 10_1101-2021_01_06_425584 64 23 1 1 CD 10_1101-2021_01_06_425584 64 24 h h NN 10_1101-2021_01_06_425584 64 25 at at IN 10_1101-2021_01_06_425584 64 26 RT RT NNP 10_1101-2021_01_06_425584 64 27 and and CC 10_1101-2021_01_06_425584 64 28 118 118 CD 10_1101-2021_01_06_425584 64 29 washed wash VBD 10_1101-2021_01_06_425584 64 30 3x 3x CD 10_1101-2021_01_06_425584 64 31 with with IN 10_1101-2021_01_06_425584 64 32 PBS PBS NNP 10_1101-2021_01_06_425584 64 33 . . . 10_1101-2021_01_06_425584 65 1 As as IN 10_1101-2021_01_06_425584 65 2 a a DT 10_1101-2021_01_06_425584 65 3 negative negative JJ 10_1101-2021_01_06_425584 65 4 control control NN 10_1101-2021_01_06_425584 65 5 , , , 10_1101-2021_01_06_425584 65 6 cells cell NNS 10_1101-2021_01_06_425584 65 7 were be VBD 10_1101-2021_01_06_425584 65 8 incubated incubate VBN 10_1101-2021_01_06_425584 65 9 only only RB 10_1101-2021_01_06_425584 65 10 with with IN 10_1101-2021_01_06_425584 65 11 secondary secondary JJ 10_1101-2021_01_06_425584 65 12 antibody antibody NN 10_1101-2021_01_06_425584 65 13 to to IN 10_1101-2021_01_06_425584 65 14 119 119 CD 10_1101-2021_01_06_425584 65 15 assess assess NN 10_1101-2021_01_06_425584 65 16 for for IN 10_1101-2021_01_06_425584 65 17 non non JJ 10_1101-2021_01_06_425584 65 18 - - JJ 10_1101-2021_01_06_425584 65 19 specific specific JJ 10_1101-2021_01_06_425584 65 20 binding binding NN 10_1101-2021_01_06_425584 65 21 . . . 10_1101-2021_01_06_425584 66 1 Cell cell NN 10_1101-2021_01_06_425584 66 2 nuclei nucleus NNS 10_1101-2021_01_06_425584 66 3 were be VBD 10_1101-2021_01_06_425584 66 4 stained stain VBN 10_1101-2021_01_06_425584 66 5 with with IN 10_1101-2021_01_06_425584 66 6 Hoechst Hoechst NNP 10_1101-2021_01_06_425584 66 7 33258 33258 CD 10_1101-2021_01_06_425584 66 8 ( ( -LRB- 10_1101-2021_01_06_425584 66 9 2 2 CD 10_1101-2021_01_06_425584 66 10 µg µg NN 10_1101-2021_01_06_425584 66 11 / / SYM 10_1101-2021_01_06_425584 66 12 ml ml NN 10_1101-2021_01_06_425584 66 13 in in IN 10_1101-2021_01_06_425584 66 14 HBSS HBSS NNP 10_1101-2021_01_06_425584 66 15 ) ) -RRB- 10_1101-2021_01_06_425584 66 16 120 120 CD 10_1101-2021_01_06_425584 66 17 for for IN 10_1101-2021_01_06_425584 66 18 30 30 CD 10_1101-2021_01_06_425584 66 19 min min NN 10_1101-2021_01_06_425584 66 20 and and CC 10_1101-2021_01_06_425584 66 21 washed wash VBD 10_1101-2021_01_06_425584 66 22 3x 3x CD 10_1101-2021_01_06_425584 66 23 with with IN 10_1101-2021_01_06_425584 66 24 PBS PBS NNP 10_1101-2021_01_06_425584 66 25 . . . 10_1101-2021_01_06_425584 67 1 Fluorescent fluorescent NN 10_1101-2021_01_06_425584 67 2 images image NNS 10_1101-2021_01_06_425584 67 3 were be VBD 10_1101-2021_01_06_425584 67 4 taken take VBN 10_1101-2021_01_06_425584 67 5 in in RP 10_1101-2021_01_06_425584 67 6 at at RB 10_1101-2021_01_06_425584 67 7 least least RBS 10_1101-2021_01_06_425584 67 8 three three CD 10_1101-2021_01_06_425584 67 9 random random JJ 10_1101-2021_01_06_425584 67 10 121 121 CD 10_1101-2021_01_06_425584 67 11 fields field NNS 10_1101-2021_01_06_425584 67 12 per per IN 10_1101-2021_01_06_425584 67 13 condition condition NN 10_1101-2021_01_06_425584 67 14 using use VBG 10_1101-2021_01_06_425584 67 15 an an DT 10_1101-2021_01_06_425584 67 16 EVOS evos NN 10_1101-2021_01_06_425584 67 17 ® ® . 10_1101-2021_01_06_425584 67 18 FLoid floid NN 10_1101-2021_01_06_425584 67 19 ® ® : 10_1101-2021_01_06_425584 67 20 Cell Cell NNP 10_1101-2021_01_06_425584 67 21 Imaging Imaging NNP 10_1101-2021_01_06_425584 67 22 Station Station NNP 10_1101-2021_01_06_425584 67 23 with with IN 10_1101-2021_01_06_425584 67 24 a a DT 10_1101-2021_01_06_425584 67 25 fixed fix VBN 10_1101-2021_01_06_425584 67 26 20x 20x NNS 10_1101-2021_01_06_425584 67 27 air air NN 10_1101-2021_01_06_425584 67 28 objective objective NN 10_1101-2021_01_06_425584 67 29 . . . 10_1101-2021_01_06_425584 68 1 122 122 CD 10_1101-2021_01_06_425584 68 2 Image image NN 10_1101-2021_01_06_425584 68 3 analysis analysis NN 10_1101-2021_01_06_425584 68 4 was be VBD 10_1101-2021_01_06_425584 68 5 performed perform VBN 10_1101-2021_01_06_425584 68 6 through through IN 10_1101-2021_01_06_425584 68 7 ImageJ ImageJ NNP 10_1101-2021_01_06_425584 68 8 software software NN 10_1101-2021_01_06_425584 68 9 ( ( -LRB- 10_1101-2021_01_06_425584 68 10 version version NN 10_1101-2021_01_06_425584 68 11 2.0.0 2.0.0 CD 10_1101-2021_01_06_425584 68 12 ) ) -RRB- 10_1101-2021_01_06_425584 68 13 . . . 10_1101-2021_01_06_425584 69 1 123 123 CD 10_1101-2021_01_06_425584 69 2 124 124 CD 10_1101-2021_01_06_425584 69 3 2.4 2.4 CD 10_1101-2021_01_06_425584 69 4 Metabolite Metabolite NNP 10_1101-2021_01_06_425584 69 5 extraction extraction NN 10_1101-2021_01_06_425584 69 6 125 125 CD 10_1101-2021_01_06_425584 69 7 Cells cell NNS 10_1101-2021_01_06_425584 69 8 were be VBD 10_1101-2021_01_06_425584 69 9 seeded seed VBN 10_1101-2021_01_06_425584 69 10 at at IN 10_1101-2021_01_06_425584 69 11 300,000 300,000 CD 10_1101-2021_01_06_425584 69 12 cells cell NNS 10_1101-2021_01_06_425584 69 13 per per IN 10_1101-2021_01_06_425584 69 14 well well NN 10_1101-2021_01_06_425584 69 15 in in IN 10_1101-2021_01_06_425584 69 16 6-well 6-well CD 10_1101-2021_01_06_425584 69 17 plates plate NNS 10_1101-2021_01_06_425584 69 18 ( ( -LRB- 10_1101-2021_01_06_425584 69 19 Corning corn VBG 10_1101-2021_01_06_425584 69 20 ® ® NN 10_1101-2021_01_06_425584 69 21 CellBIND CellBIND NNP 10_1101-2021_01_06_425584 69 22 ® ® : 10_1101-2021_01_06_425584 69 23 ) ) -RRB- 10_1101-2021_01_06_425584 69 24 and and CC 10_1101-2021_01_06_425584 69 25 treated treat VBN 10_1101-2021_01_06_425584 69 26 as as IN 10_1101-2021_01_06_425584 69 27 126 126 CD 10_1101-2021_01_06_425584 69 28 above above RB 10_1101-2021_01_06_425584 69 29 . . . 10_1101-2021_01_06_425584 70 1 After after IN 10_1101-2021_01_06_425584 70 2 HG HG NNP 10_1101-2021_01_06_425584 70 3 and and CC 10_1101-2021_01_06_425584 70 4 HI HI NNP 10_1101-2021_01_06_425584 70 5 conditions condition NNS 10_1101-2021_01_06_425584 70 6 , , , 10_1101-2021_01_06_425584 70 7 metabolites metabolite NNS 10_1101-2021_01_06_425584 70 8 were be VBD 10_1101-2021_01_06_425584 70 9 extracted extract VBN 10_1101-2021_01_06_425584 70 10 following follow VBG 10_1101-2021_01_06_425584 70 11 a a DT 10_1101-2021_01_06_425584 70 12 published publish VBN 10_1101-2021_01_06_425584 70 13 protocol protocol NN 10_1101-2021_01_06_425584 70 14 for for IN 10_1101-2021_01_06_425584 70 15 127 127 CD 10_1101-2021_01_06_425584 70 16 adherent adherent JJ 10_1101-2021_01_06_425584 70 17 cells cell NNS 10_1101-2021_01_06_425584 70 18 with with IN 10_1101-2021_01_06_425584 70 19 some some DT 10_1101-2021_01_06_425584 70 20 modifications modification NNS 10_1101-2021_01_06_425584 70 21 ( ( -LRB- 10_1101-2021_01_06_425584 70 22 20 20 CD 10_1101-2021_01_06_425584 70 23 ) ) -RRB- 10_1101-2021_01_06_425584 70 24 ( ( -LRB- 10_1101-2021_01_06_425584 70 25 Figure figure NN 10_1101-2021_01_06_425584 70 26 1 1 CD 10_1101-2021_01_06_425584 70 27 ) ) -RRB- 10_1101-2021_01_06_425584 70 28 . . . 10_1101-2021_01_06_425584 71 1 In in IN 10_1101-2021_01_06_425584 71 2 brief brief NN 10_1101-2021_01_06_425584 71 3 , , , 10_1101-2021_01_06_425584 71 4 after after IN 10_1101-2021_01_06_425584 71 5 washing wash VBG 10_1101-2021_01_06_425584 71 6 the the DT 10_1101-2021_01_06_425584 71 7 cells cell NNS 10_1101-2021_01_06_425584 71 8 3 3 CD 10_1101-2021_01_06_425584 71 9 x x NN 10_1101-2021_01_06_425584 71 10 with with IN 10_1101-2021_01_06_425584 71 11 128 128 CD 10_1101-2021_01_06_425584 71 12 PBS PBS NNP 10_1101-2021_01_06_425584 71 13 , , , 10_1101-2021_01_06_425584 71 14 500 500 CD 10_1101-2021_01_06_425584 71 15 µL µL NNP 10_1101-2021_01_06_425584 71 16 of of IN 10_1101-2021_01_06_425584 71 17 a a DT 10_1101-2021_01_06_425584 71 18 cold cold JJ 10_1101-2021_01_06_425584 71 19 mixture mixture NN 10_1101-2021_01_06_425584 71 20 of of IN 10_1101-2021_01_06_425584 71 21 methanol methanol NN 10_1101-2021_01_06_425584 71 22 : : : 10_1101-2021_01_06_425584 71 23 ethanol ethanol NN 10_1101-2021_01_06_425584 71 24 ( ( -LRB- 10_1101-2021_01_06_425584 71 25 50:50 50:50 CD 10_1101-2021_01_06_425584 71 26 , , , 10_1101-2021_01_06_425584 71 27 v v NN 10_1101-2021_01_06_425584 71 28 : : : 10_1101-2021_01_06_425584 71 29 v v LS 10_1101-2021_01_06_425584 71 30 ) ) -RRB- 10_1101-2021_01_06_425584 71 31 were be VBD 10_1101-2021_01_06_425584 71 32 added add VBN 10_1101-2021_01_06_425584 71 33 to to IN 10_1101-2021_01_06_425584 71 34 each each DT 10_1101-2021_01_06_425584 71 35 well well RB 10_1101-2021_01_06_425584 71 36 , , , 10_1101-2021_01_06_425584 71 37 covered cover VBD 10_1101-2021_01_06_425584 71 38 129 129 CD 10_1101-2021_01_06_425584 71 39 with with IN 10_1101-2021_01_06_425584 71 40 aluminum aluminum NN 10_1101-2021_01_06_425584 71 41 foil foil NN 10_1101-2021_01_06_425584 71 42 , , , 10_1101-2021_01_06_425584 71 43 and and CC 10_1101-2021_01_06_425584 71 44 incubated incubate VBD 10_1101-2021_01_06_425584 71 45 at at IN 10_1101-2021_01_06_425584 71 46 -800C -800C NNP 10_1101-2021_01_06_425584 71 47 for for IN 10_1101-2021_01_06_425584 71 48 4 4 CD 10_1101-2021_01_06_425584 71 49 h. h. NN 10_1101-2021_01_06_425584 71 50 Cells cell NNS 10_1101-2021_01_06_425584 71 51 were be VBD 10_1101-2021_01_06_425584 71 52 then then RB 10_1101-2021_01_06_425584 71 53 scrapped scrap VBN 10_1101-2021_01_06_425584 71 54 using use VBG 10_1101-2021_01_06_425584 71 55 a a DT 10_1101-2021_01_06_425584 71 56 lifter lifter NN 10_1101-2021_01_06_425584 71 57 ( ( -LRB- 10_1101-2021_01_06_425584 71 58 Fisher Fisher NNP 10_1101-2021_01_06_425584 71 59 130 130 CD 10_1101-2021_01_06_425584 71 60 Scientific Scientific NNP 10_1101-2021_01_06_425584 71 61 , , , 10_1101-2021_01_06_425584 71 62 Hampton Hampton NNP 10_1101-2021_01_06_425584 71 63 , , , 10_1101-2021_01_06_425584 71 64 NH NH NNP 10_1101-2021_01_06_425584 71 65 , , , 10_1101-2021_01_06_425584 71 66 USA USA NNP 10_1101-2021_01_06_425584 71 67 ) ) -RRB- 10_1101-2021_01_06_425584 71 68 , , , 10_1101-2021_01_06_425584 71 69 and and CC 10_1101-2021_01_06_425584 71 70 the the DT 10_1101-2021_01_06_425584 71 71 supernatant supernatant JJ 10_1101-2021_01_06_425584 71 72 was be VBD 10_1101-2021_01_06_425584 71 73 transferred transfer VBN 10_1101-2021_01_06_425584 71 74 to to IN 10_1101-2021_01_06_425584 71 75 Eppendorf Eppendorf NNP 10_1101-2021_01_06_425584 71 76 tubes tube NNS 10_1101-2021_01_06_425584 71 77 before before IN 10_1101-2021_01_06_425584 71 78 131 131 CD 10_1101-2021_01_06_425584 71 79 centrifugation centrifugation NN 10_1101-2021_01_06_425584 71 80 for for IN 10_1101-2021_01_06_425584 71 81 10 10 CD 10_1101-2021_01_06_425584 71 82 min min NN 10_1101-2021_01_06_425584 71 83 at at IN 10_1101-2021_01_06_425584 71 84 14,000 14,000 CD 10_1101-2021_01_06_425584 71 85 rpm rpm NN 10_1101-2021_01_06_425584 71 86 at at IN 10_1101-2021_01_06_425584 71 87 40C. 40c. CD 10_1101-2021_01_06_425584 72 1 The the DT 10_1101-2021_01_06_425584 72 2 supernatant supernatant JJ 10_1101-2021_01_06_425584 72 3 was be VBD 10_1101-2021_01_06_425584 72 4 transferred transfer VBN 10_1101-2021_01_06_425584 72 5 to to IN 10_1101-2021_01_06_425584 72 6 another another DT 10_1101-2021_01_06_425584 72 7 tube tube NN 10_1101-2021_01_06_425584 72 8 132 132 CD 10_1101-2021_01_06_425584 72 9 and and CC 10_1101-2021_01_06_425584 72 10 dried dry VBN 10_1101-2021_01_06_425584 72 11 down down RP 10_1101-2021_01_06_425584 72 12 by by IN 10_1101-2021_01_06_425584 72 13 SpeedVac SpeedVac NNP 10_1101-2021_01_06_425584 72 14 ™ ™ CD 10_1101-2021_01_06_425584 72 15 System System NNP 10_1101-2021_01_06_425584 72 16 ( ( -LRB- 10_1101-2021_01_06_425584 72 17 Thermo Thermo NNP 10_1101-2021_01_06_425584 72 18 Fisher Fisher NNP 10_1101-2021_01_06_425584 72 19 Scientific Scientific NNP 10_1101-2021_01_06_425584 72 20 , , , 10_1101-2021_01_06_425584 72 21 Waltham Waltham NNP 10_1101-2021_01_06_425584 72 22 , , , 10_1101-2021_01_06_425584 72 23 MA MA NNP 10_1101-2021_01_06_425584 72 24 , , , 10_1101-2021_01_06_425584 72 25 USA USA NNP 10_1101-2021_01_06_425584 72 26 ) ) -RRB- 10_1101-2021_01_06_425584 72 27 . . . 10_1101-2021_01_06_425584 73 1 Samples sample NNS 10_1101-2021_01_06_425584 73 2 133 133 CD 10_1101-2021_01_06_425584 73 3 were be VBD 10_1101-2021_01_06_425584 73 4 reconstituted reconstitute VBN 10_1101-2021_01_06_425584 73 5 in in IN 10_1101-2021_01_06_425584 73 6 water water NN 10_1101-2021_01_06_425584 73 7 / / SYM 10_1101-2021_01_06_425584 73 8 acetonitrile acetonitrile NN 10_1101-2021_01_06_425584 73 9 95:5 95:5 CD 10_1101-2021_01_06_425584 73 10 v v NN 10_1101-2021_01_06_425584 73 11 / / SYM 10_1101-2021_01_06_425584 73 12 v v NN 10_1101-2021_01_06_425584 73 13 with with IN 10_1101-2021_01_06_425584 73 14 0.1 0.1 CD 10_1101-2021_01_06_425584 73 15 % % NN 10_1101-2021_01_06_425584 73 16 formic formic NN 10_1101-2021_01_06_425584 73 17 , , , 10_1101-2021_01_06_425584 73 18 centrifuged centrifuge VBD 10_1101-2021_01_06_425584 73 19 at at IN 10_1101-2021_01_06_425584 73 20 14,000 14,000 CD 10_1101-2021_01_06_425584 73 21 rpm rpm NN 10_1101-2021_01_06_425584 73 22 for for IN 10_1101-2021_01_06_425584 73 23 134 134 CD 10_1101-2021_01_06_425584 73 24 10 10 CD 10_1101-2021_01_06_425584 73 25 min min NN 10_1101-2021_01_06_425584 73 26 at at IN 10_1101-2021_01_06_425584 73 27 4o 4o CD 10_1101-2021_01_06_425584 73 28 C. C. NNP 10_1101-2021_01_06_425584 73 29 The the DT 10_1101-2021_01_06_425584 73 30 particle particle NN 10_1101-2021_01_06_425584 73 31 free free JJ 10_1101-2021_01_06_425584 73 32 supernatant supernatant NN 10_1101-2021_01_06_425584 73 33 was be VBD 10_1101-2021_01_06_425584 73 34 recovered recover VBN 10_1101-2021_01_06_425584 73 35 for for IN 10_1101-2021_01_06_425584 73 36 further further JJ 10_1101-2021_01_06_425584 73 37 LC LC NNP 10_1101-2021_01_06_425584 73 38 - - HYPH 10_1101-2021_01_06_425584 73 39 MS2 MS2 NNP 10_1101-2021_01_06_425584 73 40 analysis analysis NN 10_1101-2021_01_06_425584 73 41 . . . 10_1101-2021_01_06_425584 74 1 135 135 CD 10_1101-2021_01_06_425584 74 2 136 136 CD 10_1101-2021_01_06_425584 74 3 2.5 2.5 CD 10_1101-2021_01_06_425584 74 4 LC LC NNP 10_1101-2021_01_06_425584 74 5 - - HYPH 10_1101-2021_01_06_425584 74 6 MS2 MS2 NNP 10_1101-2021_01_06_425584 74 7 data data NN 10_1101-2021_01_06_425584 74 8 acquisition acquisition NN 10_1101-2021_01_06_425584 74 9 for for IN 10_1101-2021_01_06_425584 74 10 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 74 11 137 137 CD 10_1101-2021_01_06_425584 74 12 Metabolites metabolite NNS 10_1101-2021_01_06_425584 74 13 were be VBD 10_1101-2021_01_06_425584 74 14 loaded load VBN 10_1101-2021_01_06_425584 74 15 into into IN 10_1101-2021_01_06_425584 74 16 an an DT 10_1101-2021_01_06_425584 74 17 Eksigent Eksigent NNP 10_1101-2021_01_06_425584 74 18 nanoLCâ nanoLCâ NNP 10_1101-2021_01_06_425584 74 19 400 400 CD 10_1101-2021_01_06_425584 74 20 system system NN 10_1101-2021_01_06_425584 74 21 ( ( -LRB- 10_1101-2021_01_06_425584 74 22 AB AB NNP 10_1101-2021_01_06_425584 74 23 Sciex Sciex NNP 10_1101-2021_01_06_425584 74 24 , , , 10_1101-2021_01_06_425584 74 25 Foster Foster NNP 10_1101-2021_01_06_425584 74 26 City City NNP 10_1101-2021_01_06_425584 74 27 , , , 10_1101-2021_01_06_425584 74 28 CA CA NNP 10_1101-2021_01_06_425584 74 29 , , , 10_1101-2021_01_06_425584 74 30 USA USA NNP 10_1101-2021_01_06_425584 74 31 ) ) -RRB- 10_1101-2021_01_06_425584 74 32 138 138 CD 10_1101-2021_01_06_425584 74 33 with with IN 10_1101-2021_01_06_425584 74 34 a a DT 10_1101-2021_01_06_425584 74 35 HALO HALO NNP 10_1101-2021_01_06_425584 74 36 Phenyl Phenyl NNP 10_1101-2021_01_06_425584 74 37 - - HYPH 10_1101-2021_01_06_425584 74 38 Hexyl Hexyl NNP 10_1101-2021_01_06_425584 74 39 column column NN 10_1101-2021_01_06_425584 74 40 ( ( -LRB- 10_1101-2021_01_06_425584 74 41 0.5 0.5 CD 10_1101-2021_01_06_425584 74 42 x x SYM 10_1101-2021_01_06_425584 74 43 50 50 CD 10_1101-2021_01_06_425584 74 44 mm mm NN 10_1101-2021_01_06_425584 74 45 , , , 10_1101-2021_01_06_425584 74 46 2.7 2.7 CD 10_1101-2021_01_06_425584 74 47 µm µm NNP 10_1101-2021_01_06_425584 74 48 , , , 10_1101-2021_01_06_425584 74 49 90 90 CD 10_1101-2021_01_06_425584 74 50 Å å JJ 10_1101-2021_01_06_425584 74 51 pore pore NN 10_1101-2021_01_06_425584 74 52 size size NN 10_1101-2021_01_06_425584 74 53 , , , 10_1101-2021_01_06_425584 74 54 Eksigent Eksigent NNP 10_1101-2021_01_06_425584 74 55 AB AB NNP 10_1101-2021_01_06_425584 74 56 Sciex Sciex NNP 10_1101-2021_01_06_425584 74 57 , , , 10_1101-2021_01_06_425584 74 58 139 139 CD 10_1101-2021_01_06_425584 74 59 Foster Foster NNP 10_1101-2021_01_06_425584 74 60 City City NNP 10_1101-2021_01_06_425584 74 61 , , , 10_1101-2021_01_06_425584 74 62 CA CA NNP 10_1101-2021_01_06_425584 74 63 , , , 10_1101-2021_01_06_425584 74 64 USA USA NNP 10_1101-2021_01_06_425584 74 65 ) ) -RRB- 10_1101-2021_01_06_425584 74 66 for for IN 10_1101-2021_01_06_425584 74 67 data datum NNS 10_1101-2021_01_06_425584 74 68 acquisition acquisition NN 10_1101-2021_01_06_425584 74 69 using use VBG 10_1101-2021_01_06_425584 74 70 the the DT 10_1101-2021_01_06_425584 74 71 LC LC NNP 10_1101-2021_01_06_425584 74 72 - - HYPH 10_1101-2021_01_06_425584 74 73 MS MS NNP 10_1101-2021_01_06_425584 74 74 parameters parameter NNS 10_1101-2021_01_06_425584 74 75 previously previously RB 10_1101-2021_01_06_425584 74 76 described describe VBD 10_1101-2021_01_06_425584 74 77 with with IN 10_1101-2021_01_06_425584 74 78 140 140 CD 10_1101-2021_01_06_425584 74 79 some some DT 10_1101-2021_01_06_425584 74 80 modifications modification NNS 10_1101-2021_01_06_425584 74 81 ( ( -LRB- 10_1101-2021_01_06_425584 74 82 21 21 CD 10_1101-2021_01_06_425584 74 83 ) ) -RRB- 10_1101-2021_01_06_425584 74 84 . . . 10_1101-2021_01_06_425584 75 1 In in IN 10_1101-2021_01_06_425584 75 2 brief brief NN 10_1101-2021_01_06_425584 75 3 , , , 10_1101-2021_01_06_425584 75 4 the the DT 10_1101-2021_01_06_425584 75 5 separation separation NN 10_1101-2021_01_06_425584 75 6 of of IN 10_1101-2021_01_06_425584 75 7 metabolites metabolite NNS 10_1101-2021_01_06_425584 75 8 was be VBD 10_1101-2021_01_06_425584 75 9 performed perform VBN 10_1101-2021_01_06_425584 75 10 using use VBG 10_1101-2021_01_06_425584 75 11 gradient gradient NNP 10_1101-2021_01_06_425584 75 12 141 141 CD 10_1101-2021_01_06_425584 75 13 elution elution NN 10_1101-2021_01_06_425584 75 14 with with IN 10_1101-2021_01_06_425584 75 15 0.1 0.1 CD 10_1101-2021_01_06_425584 75 16 % % NN 10_1101-2021_01_06_425584 75 17 formic formic NN 10_1101-2021_01_06_425584 75 18 acid acid NN 10_1101-2021_01_06_425584 75 19 in in IN 10_1101-2021_01_06_425584 75 20 water water NN 10_1101-2021_01_06_425584 75 21 ( ( -LRB- 10_1101-2021_01_06_425584 75 22 A a NN 10_1101-2021_01_06_425584 75 23 ) ) -RRB- 10_1101-2021_01_06_425584 75 24 and and CC 10_1101-2021_01_06_425584 75 25 0.1 0.1 CD 10_1101-2021_01_06_425584 75 26 % % NN 10_1101-2021_01_06_425584 75 27 formic formic NN 10_1101-2021_01_06_425584 75 28 acid acid NN 10_1101-2021_01_06_425584 75 29 in in IN 10_1101-2021_01_06_425584 75 30 ACN ACN NNP 10_1101-2021_01_06_425584 75 31 ( ( -LRB- 10_1101-2021_01_06_425584 75 32 B B NNP 10_1101-2021_01_06_425584 75 33 ) ) -RRB- 10_1101-2021_01_06_425584 75 34 as as IN 10_1101-2021_01_06_425584 75 35 mobile mobile JJ 10_1101-2021_01_06_425584 75 36 phases phase VBZ 10_1101-2021_01_06_425584 75 37 at at IN 10_1101-2021_01_06_425584 75 38 a a DT 10_1101-2021_01_06_425584 75 39 142 142 CD 10_1101-2021_01_06_425584 75 40 constant constant JJ 10_1101-2021_01_06_425584 75 41 flow flow NN 10_1101-2021_01_06_425584 75 42 rate rate NN 10_1101-2021_01_06_425584 75 43 of of IN 10_1101-2021_01_06_425584 75 44 5 5 CD 10_1101-2021_01_06_425584 75 45 µL µL NNP 10_1101-2021_01_06_425584 75 46 / / SYM 10_1101-2021_01_06_425584 75 47 min min NNP 10_1101-2021_01_06_425584 75 48 . . . 10_1101-2021_01_06_425584 76 1 The the DT 10_1101-2021_01_06_425584 76 2 gradient gradient NN 10_1101-2021_01_06_425584 76 3 started start VBD 10_1101-2021_01_06_425584 76 4 with with IN 10_1101-2021_01_06_425584 76 5 5 5 CD 10_1101-2021_01_06_425584 76 6 % % NN 10_1101-2021_01_06_425584 76 7 B b NN 10_1101-2021_01_06_425584 76 8 for for IN 10_1101-2021_01_06_425584 76 9 1 1 CD 10_1101-2021_01_06_425584 76 10 min min NN 10_1101-2021_01_06_425584 76 11 followed follow VBN 10_1101-2021_01_06_425584 76 12 by by IN 10_1101-2021_01_06_425584 76 13 a a DT 10_1101-2021_01_06_425584 76 14 stepped step VBN 10_1101-2021_01_06_425584 76 15 143 143 CD 10_1101-2021_01_06_425584 76 16 increase increase NN 10_1101-2021_01_06_425584 76 17 to to IN 10_1101-2021_01_06_425584 76 18 100 100 CD 10_1101-2021_01_06_425584 76 19 % % NN 10_1101-2021_01_06_425584 76 20 , , , 10_1101-2021_01_06_425584 76 21 B b NN 10_1101-2021_01_06_425584 76 22 over over IN 10_1101-2021_01_06_425584 76 23 26 26 CD 10_1101-2021_01_06_425584 76 24 min min NN 10_1101-2021_01_06_425584 76 25 and and CC 10_1101-2021_01_06_425584 76 26 held hold VBD 10_1101-2021_01_06_425584 76 27 constant constant JJ 10_1101-2021_01_06_425584 76 28 for for IN 10_1101-2021_01_06_425584 76 29 4 4 CD 10_1101-2021_01_06_425584 76 30 min min NN 10_1101-2021_01_06_425584 76 31 . . . 10_1101-2021_01_06_425584 77 1 Solvent solvent JJ 10_1101-2021_01_06_425584 77 2 composition composition NN 10_1101-2021_01_06_425584 77 3 was be VBD 10_1101-2021_01_06_425584 77 4 returned return VBN 10_1101-2021_01_06_425584 77 5 144 144 CD 10_1101-2021_01_06_425584 77 6 to to TO 10_1101-2021_01_06_425584 77 7 5 5 CD 10_1101-2021_01_06_425584 77 8 % % NN 10_1101-2021_01_06_425584 77 9 B b NN 10_1101-2021_01_06_425584 77 10 for for IN 10_1101-2021_01_06_425584 77 11 0.1 0.1 CD 10_1101-2021_01_06_425584 77 12 min min NN 10_1101-2021_01_06_425584 77 13 . . . 10_1101-2021_01_06_425584 78 1 Column column NN 10_1101-2021_01_06_425584 78 2 re re NN 10_1101-2021_01_06_425584 78 3 - - NN 10_1101-2021_01_06_425584 78 4 equilibration equilibration NN 10_1101-2021_01_06_425584 78 5 was be VBD 10_1101-2021_01_06_425584 78 6 carried carry VBN 10_1101-2021_01_06_425584 78 7 out out RP 10_1101-2021_01_06_425584 78 8 with with IN 10_1101-2021_01_06_425584 78 9 5 5 CD 10_1101-2021_01_06_425584 78 10 % % NN 10_1101-2021_01_06_425584 78 11 mobile mobile JJ 10_1101-2021_01_06_425584 78 12 phase phase NN 10_1101-2021_01_06_425584 78 13 B b NN 10_1101-2021_01_06_425584 78 14 for for IN 10_1101-2021_01_06_425584 78 15 4 4 CD 10_1101-2021_01_06_425584 78 16 minutes minute NNS 10_1101-2021_01_06_425584 78 17 . . . 10_1101-2021_01_06_425584 79 1 145 145 CD 10_1101-2021_01_06_425584 79 2 Potential potential JJ 10_1101-2021_01_06_425584 79 3 carryover carryover NN 10_1101-2021_01_06_425584 79 4 was be VBD 10_1101-2021_01_06_425584 79 5 minimized minimize VBN 10_1101-2021_01_06_425584 79 6 with with IN 10_1101-2021_01_06_425584 79 7 a a DT 10_1101-2021_01_06_425584 79 8 blank blank JJ 10_1101-2021_01_06_425584 79 9 run run NN 10_1101-2021_01_06_425584 79 10 ( ( -LRB- 10_1101-2021_01_06_425584 79 11 1 1 CD 10_1101-2021_01_06_425584 79 12 µL µl CD 10_1101-2021_01_06_425584 79 13 buffer buffer NN 10_1101-2021_01_06_425584 79 14 A a NN 10_1101-2021_01_06_425584 79 15 ) ) -RRB- 10_1101-2021_01_06_425584 79 16 between between IN 10_1101-2021_01_06_425584 79 17 sample sample NN 10_1101-2021_01_06_425584 79 18 experimental experimental JJ 10_1101-2021_01_06_425584 79 19 146 146 CD 10_1101-2021_01_06_425584 79 20 samples sample NNS 10_1101-2021_01_06_425584 79 21 . . . 10_1101-2021_01_06_425584 80 1 The the DT 10_1101-2021_01_06_425584 80 2 eluate eluate NN 10_1101-2021_01_06_425584 80 3 from from IN 10_1101-2021_01_06_425584 80 4 the the DT 10_1101-2021_01_06_425584 80 5 LC LC NNP 10_1101-2021_01_06_425584 80 6 was be VBD 10_1101-2021_01_06_425584 80 7 delivered deliver VBN 10_1101-2021_01_06_425584 80 8 directly directly RB 10_1101-2021_01_06_425584 80 9 to to IN 10_1101-2021_01_06_425584 80 10 the the DT 10_1101-2021_01_06_425584 80 11 TurboV turbov JJ 10_1101-2021_01_06_425584 80 12 source source NN 10_1101-2021_01_06_425584 80 13 of of IN 10_1101-2021_01_06_425584 80 14 a a DT 10_1101-2021_01_06_425584 80 15 TripleTOF TripleTOF NNP 10_1101-2021_01_06_425584 80 16 147 147 CD 10_1101-2021_01_06_425584 80 17 5600 5600 CD 10_1101-2021_01_06_425584 80 18 + + CC 10_1101-2021_01_06_425584 80 19 mass mass NN 10_1101-2021_01_06_425584 80 20 spectrometer spectrometer NN 10_1101-2021_01_06_425584 80 21 ( ( -LRB- 10_1101-2021_01_06_425584 80 22 AB AB NNP 10_1101-2021_01_06_425584 80 23 Sciex Sciex NNP 10_1101-2021_01_06_425584 80 24 , , , 10_1101-2021_01_06_425584 80 25 Foster Foster NNP 10_1101-2021_01_06_425584 80 26 City City NNP 10_1101-2021_01_06_425584 80 27 , , , 10_1101-2021_01_06_425584 80 28 CA CA NNP 10_1101-2021_01_06_425584 80 29 , , , 10_1101-2021_01_06_425584 80 30 USA USA NNP 10_1101-2021_01_06_425584 80 31 ) ) -RRB- 10_1101-2021_01_06_425584 80 32 using use VBG 10_1101-2021_01_06_425584 80 33 electrospray electrospray JJ 10_1101-2021_01_06_425584 80 34 ionization ionization NN 10_1101-2021_01_06_425584 80 35 ( ( -LRB- 10_1101-2021_01_06_425584 80 36 ESI ESI NNP 10_1101-2021_01_06_425584 80 37 ) ) -RRB- 10_1101-2021_01_06_425584 80 38 148 148 CD 10_1101-2021_01_06_425584 80 39 under under IN 10_1101-2021_01_06_425584 80 40 positive positive JJ 10_1101-2021_01_06_425584 80 41 mode mode NN 10_1101-2021_01_06_425584 80 42 . . . 10_1101-2021_01_06_425584 81 1 ESI ESI NNP 10_1101-2021_01_06_425584 81 2 source source NN 10_1101-2021_01_06_425584 81 3 conditions condition NNS 10_1101-2021_01_06_425584 81 4 were be VBD 10_1101-2021_01_06_425584 81 5 set set VBN 10_1101-2021_01_06_425584 81 6 as as IN 10_1101-2021_01_06_425584 81 7 follows follow VBZ 10_1101-2021_01_06_425584 81 8 : : : 10_1101-2021_01_06_425584 81 9 IonSpray IonSpray NNP 10_1101-2021_01_06_425584 81 10 Voltage Voltage NNP 10_1101-2021_01_06_425584 81 11 Floating Floating NNP 10_1101-2021_01_06_425584 81 12 , , , 10_1101-2021_01_06_425584 81 13 5500 5500 CD 10_1101-2021_01_06_425584 81 14 149 149 CD 10_1101-2021_01_06_425584 81 15 V v NN 10_1101-2021_01_06_425584 81 16 ; ; : 10_1101-2021_01_06_425584 81 17 Source source NN 10_1101-2021_01_06_425584 81 18 temperature temperature NN 10_1101-2021_01_06_425584 81 19 , , , 10_1101-2021_01_06_425584 81 20 350 350 CD 10_1101-2021_01_06_425584 81 21 ° ° , 10_1101-2021_01_06_425584 81 22 C C NNP 10_1101-2021_01_06_425584 81 23 ; ; : 10_1101-2021_01_06_425584 81 24 Curtain curtain JJ 10_1101-2021_01_06_425584 81 25 gas gas NN 10_1101-2021_01_06_425584 81 26 , , , 10_1101-2021_01_06_425584 81 27 20 20 CD 10_1101-2021_01_06_425584 81 28 psi psi NN 10_1101-2021_01_06_425584 81 29 ; ; : 10_1101-2021_01_06_425584 81 30 Ion Ion NNP 10_1101-2021_01_06_425584 81 31 source source NN 10_1101-2021_01_06_425584 81 32 gases gas VBZ 10_1101-2021_01_06_425584 81 33 1 1 CD 10_1101-2021_01_06_425584 81 34 and and CC 10_1101-2021_01_06_425584 81 35 2 2 CD 10_1101-2021_01_06_425584 81 36 were be VBD 10_1101-2021_01_06_425584 81 37 set set VBN 10_1101-2021_01_06_425584 81 38 to to IN 10_1101-2021_01_06_425584 81 39 40 40 CD 10_1101-2021_01_06_425584 81 40 and and CC 10_1101-2021_01_06_425584 81 41 150 150 CD 10_1101-2021_01_06_425584 81 42 .CC .CC : 10_1101-2021_01_06_425584 81 43 - - HYPH 10_1101-2021_01_06_425584 81 44 BY by IN 10_1101-2021_01_06_425584 81 45 - - HYPH 10_1101-2021_01_06_425584 81 46 NC NC NNP 10_1101-2021_01_06_425584 81 47 - - HYPH 10_1101-2021_01_06_425584 81 48 ND ND NNP 10_1101-2021_01_06_425584 81 49 4.0 4.0 CD 10_1101-2021_01_06_425584 81 50 International International NNP 10_1101-2021_01_06_425584 81 51 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 81 52 under under IN 10_1101-2021_01_06_425584 81 53 a a DT 10_1101-2021_01_06_425584 81 54 ( ( -LRB- 10_1101-2021_01_06_425584 81 55 which which WDT 10_1101-2021_01_06_425584 81 56 was be VBD 10_1101-2021_01_06_425584 81 57 not not RB 10_1101-2021_01_06_425584 81 58 certified certify VBN 10_1101-2021_01_06_425584 81 59 by by IN 10_1101-2021_01_06_425584 81 60 peer peer NN 10_1101-2021_01_06_425584 81 61 review review NN 10_1101-2021_01_06_425584 81 62 ) ) -RRB- 10_1101-2021_01_06_425584 81 63 is be VBZ 10_1101-2021_01_06_425584 81 64 the the DT 10_1101-2021_01_06_425584 81 65 author author NN 10_1101-2021_01_06_425584 81 66 / / SYM 10_1101-2021_01_06_425584 81 67 funder funder NN 10_1101-2021_01_06_425584 81 68 , , , 10_1101-2021_01_06_425584 81 69 who who WP 10_1101-2021_01_06_425584 81 70 has have VBZ 10_1101-2021_01_06_425584 81 71 granted grant VBN 10_1101-2021_01_06_425584 81 72 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 81 73 a a DT 10_1101-2021_01_06_425584 81 74 license license NN 10_1101-2021_01_06_425584 81 75 to to TO 10_1101-2021_01_06_425584 81 76 display display VB 10_1101-2021_01_06_425584 81 77 the the DT 10_1101-2021_01_06_425584 81 78 preprint preprint NN 10_1101-2021_01_06_425584 81 79 in in IN 10_1101-2021_01_06_425584 81 80 perpetuity perpetuity NN 10_1101-2021_01_06_425584 81 81 . . . 10_1101-2021_01_06_425584 82 1 It -PRON- PRP 10_1101-2021_01_06_425584 82 2 is be VBZ 10_1101-2021_01_06_425584 82 3 made make VBN 10_1101-2021_01_06_425584 82 4 The the DT 10_1101-2021_01_06_425584 82 5 copyright copyright NN 10_1101-2021_01_06_425584 82 6 holder holder NN 10_1101-2021_01_06_425584 82 7 for for IN 10_1101-2021_01_06_425584 82 8 this this DT 10_1101-2021_01_06_425584 82 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 82 10 version version NN 10_1101-2021_01_06_425584 82 11 posted post VBD 10_1101-2021_01_06_425584 82 12 January January NNP 10_1101-2021_01_06_425584 82 13 8 8 CD 10_1101-2021_01_06_425584 82 14 , , , 10_1101-2021_01_06_425584 82 15 2021 2021 CD 10_1101-2021_01_06_425584 82 16 . . . 10_1101-2021_01_06_425584 82 17 ; ; : 10_1101-2021_01_06_425584 82 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 82 19 : : : 10_1101-2021_01_06_425584 82 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 82 21 preprint preprint NN 10_1101-2021_01_06_425584 82 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 82 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 82 24 6 6 CD 10_1101-2021_01_06_425584 82 25 45 45 CD 10_1101-2021_01_06_425584 82 26 psi psi NN 10_1101-2021_01_06_425584 82 27 ; ; : 10_1101-2021_01_06_425584 82 28 Declustering declustere VBG 10_1101-2021_01_06_425584 82 29 potential potential NN 10_1101-2021_01_06_425584 82 30 , , , 10_1101-2021_01_06_425584 82 31 100 100 CD 10_1101-2021_01_06_425584 82 32 V. V. NNP 10_1101-2021_01_06_425584 82 33 Data Data NNP 10_1101-2021_01_06_425584 82 34 was be VBD 10_1101-2021_01_06_425584 82 35 acquired acquire VBN 10_1101-2021_01_06_425584 82 36 using use VBG 10_1101-2021_01_06_425584 82 37 information information NN 10_1101-2021_01_06_425584 82 38 - - HYPH 10_1101-2021_01_06_425584 82 39 dependent dependent JJ 10_1101-2021_01_06_425584 82 40 acquisition acquisition NN 10_1101-2021_01_06_425584 82 41 151 151 CD 10_1101-2021_01_06_425584 82 42 ( ( -LRB- 10_1101-2021_01_06_425584 82 43 IDA IDA NNP 10_1101-2021_01_06_425584 82 44 ) ) -RRB- 10_1101-2021_01_06_425584 82 45 with with IN 10_1101-2021_01_06_425584 82 46 high high JJ 10_1101-2021_01_06_425584 82 47 sensitivity sensitivity NN 10_1101-2021_01_06_425584 82 48 mode mode NN 10_1101-2021_01_06_425584 82 49 selected select VBN 10_1101-2021_01_06_425584 82 50 , , , 10_1101-2021_01_06_425584 82 51 automatically automatically RB 10_1101-2021_01_06_425584 82 52 switching switch VBG 10_1101-2021_01_06_425584 82 53 between between IN 10_1101-2021_01_06_425584 82 54 full full JJ 10_1101-2021_01_06_425584 82 55 - - HYPH 10_1101-2021_01_06_425584 82 56 scan scan JJ 10_1101-2021_01_06_425584 82 57 MS MS NNP 10_1101-2021_01_06_425584 82 58 and and CC 10_1101-2021_01_06_425584 82 59 152 152 CD 10_1101-2021_01_06_425584 82 60 MS MS NNP 10_1101-2021_01_06_425584 82 61 / / SYM 10_1101-2021_01_06_425584 82 62 MS MS NNP 10_1101-2021_01_06_425584 82 63 . . . 10_1101-2021_01_06_425584 83 1 The the DT 10_1101-2021_01_06_425584 83 2 accumulation accumulation NN 10_1101-2021_01_06_425584 83 3 time time NN 10_1101-2021_01_06_425584 83 4 for for IN 10_1101-2021_01_06_425584 83 5 TOF TOF NNP 10_1101-2021_01_06_425584 83 6 MS MS NNP 10_1101-2021_01_06_425584 83 7 was be VBD 10_1101-2021_01_06_425584 83 8 0.25 0.25 CD 10_1101-2021_01_06_425584 83 9 s s NNPS 10_1101-2021_01_06_425584 83 10 / / SYM 10_1101-2021_01_06_425584 83 11 spectra spectra NNP 10_1101-2021_01_06_425584 83 12 over over IN 10_1101-2021_01_06_425584 83 13 the the DT 10_1101-2021_01_06_425584 83 14 m m NNP 10_1101-2021_01_06_425584 83 15 / / SYM 10_1101-2021_01_06_425584 83 16 z z NNP 10_1101-2021_01_06_425584 83 17 range range NN 10_1101-2021_01_06_425584 83 18 100 100 CD 10_1101-2021_01_06_425584 83 19 - - HYPH 10_1101-2021_01_06_425584 83 20 1500 1500 CD 10_1101-2021_01_06_425584 83 21 Da Da NNP 10_1101-2021_01_06_425584 83 22 153 153 CD 10_1101-2021_01_06_425584 83 23 and and CC 10_1101-2021_01_06_425584 83 24 for for IN 10_1101-2021_01_06_425584 83 25 MS MS NNP 10_1101-2021_01_06_425584 83 26 / / SYM 10_1101-2021_01_06_425584 83 27 MS MS NNP 10_1101-2021_01_06_425584 83 28 scan scan NNP 10_1101-2021_01_06_425584 83 29 was be VBD 10_1101-2021_01_06_425584 83 30 0.05 0.05 CD 10_1101-2021_01_06_425584 83 31 s s NNPS 10_1101-2021_01_06_425584 83 32 / / SYM 10_1101-2021_01_06_425584 83 33 spectra spectra NNP 10_1101-2021_01_06_425584 83 34 over over IN 10_1101-2021_01_06_425584 83 35 the the DT 10_1101-2021_01_06_425584 83 36 m m NNP 10_1101-2021_01_06_425584 83 37 / / SYM 10_1101-2021_01_06_425584 83 38 z z NNP 10_1101-2021_01_06_425584 83 39 50 50 CD 10_1101-2021_01_06_425584 83 40 - - SYM 10_1101-2021_01_06_425584 83 41 1500 1500 CD 10_1101-2021_01_06_425584 83 42 Da Da NNP 10_1101-2021_01_06_425584 83 43 . . . 10_1101-2021_01_06_425584 84 1 The the DT 10_1101-2021_01_06_425584 84 2 IDA IDA NNP 10_1101-2021_01_06_425584 84 3 settings setting NNS 10_1101-2021_01_06_425584 84 4 were be VBD 10_1101-2021_01_06_425584 84 5 as as IN 10_1101-2021_01_06_425584 84 6 154 154 CD 10_1101-2021_01_06_425584 84 7 follows follow VBZ 10_1101-2021_01_06_425584 84 8 charge charge NN 10_1101-2021_01_06_425584 84 9 state state NN 10_1101-2021_01_06_425584 84 10 +1 +1 NNS 10_1101-2021_01_06_425584 84 11 to to IN 10_1101-2021_01_06_425584 84 12 +2 +2 NNP 10_1101-2021_01_06_425584 84 13 , , , 10_1101-2021_01_06_425584 84 14 intensity intensity NN 10_1101-2021_01_06_425584 84 15 125 125 CD 10_1101-2021_01_06_425584 84 16 cps cps NN 10_1101-2021_01_06_425584 84 17 , , , 10_1101-2021_01_06_425584 84 18 exclude exclude VBP 10_1101-2021_01_06_425584 84 19 isotopes isotope VBZ 10_1101-2021_01_06_425584 84 20 within within IN 10_1101-2021_01_06_425584 84 21 6 6 CD 10_1101-2021_01_06_425584 84 22 Da Da NNP 10_1101-2021_01_06_425584 84 23 , , , 10_1101-2021_01_06_425584 84 24 mass mass NN 10_1101-2021_01_06_425584 84 25 tolerance tolerance NN 10_1101-2021_01_06_425584 84 26 50 50 CD 10_1101-2021_01_06_425584 84 27 155 155 CD 10_1101-2021_01_06_425584 84 28 mDa mDa NNS 10_1101-2021_01_06_425584 84 29 , , , 10_1101-2021_01_06_425584 84 30 and and CC 10_1101-2021_01_06_425584 84 31 a a DT 10_1101-2021_01_06_425584 84 32 maximum maximum JJ 10_1101-2021_01_06_425584 84 33 number number NN 10_1101-2021_01_06_425584 84 34 of of IN 10_1101-2021_01_06_425584 84 35 candidate candidate NN 10_1101-2021_01_06_425584 84 36 ions ion NNS 10_1101-2021_01_06_425584 84 37 20 20 CD 10_1101-2021_01_06_425584 84 38 . . . 10_1101-2021_01_06_425584 85 1 Under under IN 10_1101-2021_01_06_425584 85 2 IDA IDA NNP 10_1101-2021_01_06_425584 85 3 settings setting NNS 10_1101-2021_01_06_425584 85 4 , , , 10_1101-2021_01_06_425584 85 5 the the DT 10_1101-2021_01_06_425584 85 6 ‘ ' `` 10_1101-2021_01_06_425584 85 7 ‘ ' `` 10_1101-2021_01_06_425584 85 8 exclude exclude VB 10_1101-2021_01_06_425584 85 9 former former JJ 10_1101-2021_01_06_425584 85 10 156 156 CD 10_1101-2021_01_06_425584 85 11 target target NN 10_1101-2021_01_06_425584 85 12 ions ion NNS 10_1101-2021_01_06_425584 85 13 ’ ' '' 10_1101-2021_01_06_425584 85 14 ’ ' '' 10_1101-2021_01_06_425584 85 15 was be VBD 10_1101-2021_01_06_425584 85 16 set set VBN 10_1101-2021_01_06_425584 85 17 as as IN 10_1101-2021_01_06_425584 85 18 15 15 CD 10_1101-2021_01_06_425584 85 19 s s NN 10_1101-2021_01_06_425584 85 20 after after IN 10_1101-2021_01_06_425584 85 21 two two CD 10_1101-2021_01_06_425584 85 22 occurrences occurrence NNS 10_1101-2021_01_06_425584 85 23 and and CC 10_1101-2021_01_06_425584 85 24 ‘ ' `` 10_1101-2021_01_06_425584 85 25 ‘ ' `` 10_1101-2021_01_06_425584 85 26 dynamic dynamic JJ 10_1101-2021_01_06_425584 85 27 background background NN 10_1101-2021_01_06_425584 85 28 subtract subtract NN 10_1101-2021_01_06_425584 85 29 ’ ' '' 10_1101-2021_01_06_425584 85 30 ’ ' '' 10_1101-2021_01_06_425584 85 31 was be VBD 10_1101-2021_01_06_425584 85 32 157 157 CD 10_1101-2021_01_06_425584 85 33 selected select VBN 10_1101-2021_01_06_425584 85 34 . . . 10_1101-2021_01_06_425584 86 1 Manufacturer manufacturer NN 10_1101-2021_01_06_425584 86 2 rolling roll VBG 10_1101-2021_01_06_425584 86 3 collision collision NN 10_1101-2021_01_06_425584 86 4 energy energy NN 10_1101-2021_01_06_425584 86 5 ( ( -LRB- 10_1101-2021_01_06_425584 86 6 CE CE NNP 10_1101-2021_01_06_425584 86 7 ) ) -RRB- 10_1101-2021_01_06_425584 86 8 option option NN 10_1101-2021_01_06_425584 86 9 was be VBD 10_1101-2021_01_06_425584 86 10 used use VBN 10_1101-2021_01_06_425584 86 11 based base VBN 10_1101-2021_01_06_425584 86 12 on on IN 10_1101-2021_01_06_425584 86 13 the the DT 10_1101-2021_01_06_425584 86 14 size size NN 10_1101-2021_01_06_425584 86 15 and and CC 10_1101-2021_01_06_425584 86 16 158 158 CD 10_1101-2021_01_06_425584 86 17 charge charge NN 10_1101-2021_01_06_425584 86 18 of of IN 10_1101-2021_01_06_425584 86 19 the the DT 10_1101-2021_01_06_425584 86 20 precursor precursor NN 10_1101-2021_01_06_425584 86 21 ion ion NN 10_1101-2021_01_06_425584 86 22 using use VBG 10_1101-2021_01_06_425584 86 23 formula formula NN 10_1101-2021_01_06_425584 86 24 CE CE NNP 10_1101-2021_01_06_425584 86 25 = = SYM 10_1101-2021_01_06_425584 86 26 m m NNP 10_1101-2021_01_06_425584 86 27 / / SYM 10_1101-2021_01_06_425584 86 28 z z NNP 10_1101-2021_01_06_425584 86 29 x x SYM 10_1101-2021_01_06_425584 86 30 0.0575 0.0575 CD 10_1101-2021_01_06_425584 86 31 + + SYM 10_1101-2021_01_06_425584 86 32 9 9 CD 10_1101-2021_01_06_425584 86 33 . . . 10_1101-2021_01_06_425584 87 1 The the DT 10_1101-2021_01_06_425584 87 2 instrument instrument NN 10_1101-2021_01_06_425584 87 3 was be VBD 10_1101-2021_01_06_425584 87 4 automatically automatically RB 10_1101-2021_01_06_425584 87 5 159 159 CD 10_1101-2021_01_06_425584 87 6 calibrated calibrate VBN 10_1101-2021_01_06_425584 87 7 by by IN 10_1101-2021_01_06_425584 87 8 the the DT 10_1101-2021_01_06_425584 87 9 batch batch NN 10_1101-2021_01_06_425584 87 10 mode mode NN 10_1101-2021_01_06_425584 87 11 using use VBG 10_1101-2021_01_06_425584 87 12 appropriate appropriate JJ 10_1101-2021_01_06_425584 87 13 positive positive JJ 10_1101-2021_01_06_425584 87 14 TOF TOF NNP 10_1101-2021_01_06_425584 87 15 MS MS NNP 10_1101-2021_01_06_425584 87 16 and and CC 10_1101-2021_01_06_425584 87 17 MS MS NNP 10_1101-2021_01_06_425584 87 18 / / SYM 10_1101-2021_01_06_425584 87 19 MS MS NNP 10_1101-2021_01_06_425584 87 20 calibration calibration NN 10_1101-2021_01_06_425584 87 21 solutions solution VBZ 10_1101-2021_01_06_425584 87 22 160 160 CD 10_1101-2021_01_06_425584 87 23 before before IN 10_1101-2021_01_06_425584 87 24 sample sample NN 10_1101-2021_01_06_425584 87 25 injection injection NN 10_1101-2021_01_06_425584 87 26 and and CC 10_1101-2021_01_06_425584 87 27 after after IN 10_1101-2021_01_06_425584 87 28 injection injection NN 10_1101-2021_01_06_425584 87 29 of of IN 10_1101-2021_01_06_425584 87 30 two two CD 10_1101-2021_01_06_425584 87 31 samples sample NNS 10_1101-2021_01_06_425584 87 32 ( ( -LRB- 10_1101-2021_01_06_425584 87 33 < < XX 10_1101-2021_01_06_425584 87 34 3.5 3.5 CD 10_1101-2021_01_06_425584 87 35 working work VBG 10_1101-2021_01_06_425584 87 36 hours hour NNS 10_1101-2021_01_06_425584 87 37 ) ) -RRB- 10_1101-2021_01_06_425584 87 38 to to TO 10_1101-2021_01_06_425584 87 39 ensure ensure VB 10_1101-2021_01_06_425584 87 40 a a DT 10_1101-2021_01_06_425584 87 41 mass mass NN 10_1101-2021_01_06_425584 87 42 161 161 CD 10_1101-2021_01_06_425584 87 43 accuracy accuracy NN 10_1101-2021_01_06_425584 87 44 of of IN 10_1101-2021_01_06_425584 87 45 < < XX 10_1101-2021_01_06_425584 87 46 5 5 CD 10_1101-2021_01_06_425584 87 47 ppm ppm NN 10_1101-2021_01_06_425584 87 48 for for IN 10_1101-2021_01_06_425584 87 49 both both DT 10_1101-2021_01_06_425584 87 50 MS MS NNP 10_1101-2021_01_06_425584 87 51 and and CC 10_1101-2021_01_06_425584 87 52 MS MS NNP 10_1101-2021_01_06_425584 87 53 / / SYM 10_1101-2021_01_06_425584 87 54 MS MS NNP 10_1101-2021_01_06_425584 87 55 data datum NNS 10_1101-2021_01_06_425584 87 56 . . . 10_1101-2021_01_06_425584 88 1 Instrument instrument NN 10_1101-2021_01_06_425584 88 2 performance performance NN 10_1101-2021_01_06_425584 88 3 was be VBD 10_1101-2021_01_06_425584 88 4 monitored monitor VBN 10_1101-2021_01_06_425584 88 5 during during IN 10_1101-2021_01_06_425584 88 6 162 162 CD 10_1101-2021_01_06_425584 88 7 data datum NNS 10_1101-2021_01_06_425584 88 8 acquisition acquisition NN 10_1101-2021_01_06_425584 88 9 by by IN 10_1101-2021_01_06_425584 88 10 including include VBG 10_1101-2021_01_06_425584 88 11 QC QC NNP 10_1101-2021_01_06_425584 88 12 samples sample NNS 10_1101-2021_01_06_425584 88 13 ( ( -LRB- 10_1101-2021_01_06_425584 88 14 pooled pool VBN 10_1101-2021_01_06_425584 88 15 samples sample NNS 10_1101-2021_01_06_425584 88 16 of of IN 10_1101-2021_01_06_425584 88 17 equal equal JJ 10_1101-2021_01_06_425584 88 18 volume volume NN 10_1101-2021_01_06_425584 88 19 ) ) -RRB- 10_1101-2021_01_06_425584 88 20 every every DT 10_1101-2021_01_06_425584 88 21 4 4 CD 10_1101-2021_01_06_425584 88 22 experimental experimental JJ 10_1101-2021_01_06_425584 88 23 163 163 CD 10_1101-2021_01_06_425584 88 24 samples sample NNS 10_1101-2021_01_06_425584 88 25 . . . 10_1101-2021_01_06_425584 89 1 Data datum NNS 10_1101-2021_01_06_425584 89 2 acquisition acquisition NN 10_1101-2021_01_06_425584 89 3 of of IN 10_1101-2021_01_06_425584 89 4 experimental experimental JJ 10_1101-2021_01_06_425584 89 5 samples sample NNS 10_1101-2021_01_06_425584 89 6 was be VBD 10_1101-2021_01_06_425584 89 7 also also RB 10_1101-2021_01_06_425584 89 8 randomized randomize VBN 10_1101-2021_01_06_425584 89 9 . . . 10_1101-2021_01_06_425584 90 1 164 164 CD 10_1101-2021_01_06_425584 90 2 165 165 CD 10_1101-2021_01_06_425584 90 3 2.6 2.6 CD 10_1101-2021_01_06_425584 90 4 Metabolomics Metabolomics NNPS 10_1101-2021_01_06_425584 90 5 data datum NNS 10_1101-2021_01_06_425584 90 6 processing process VBG 10_1101-2021_01_06_425584 90 7 166 166 CD 10_1101-2021_01_06_425584 90 8 Mass Mass NNP 10_1101-2021_01_06_425584 90 9 detection detection NN 10_1101-2021_01_06_425584 90 10 , , , 10_1101-2021_01_06_425584 90 11 chromatogram chromatogram JJ 10_1101-2021_01_06_425584 90 12 building building NN 10_1101-2021_01_06_425584 90 13 and and CC 10_1101-2021_01_06_425584 90 14 deconvolution deconvolution NN 10_1101-2021_01_06_425584 90 15 , , , 10_1101-2021_01_06_425584 90 16 isotopic isotopic JJ 10_1101-2021_01_06_425584 90 17 assignment assignment NN 10_1101-2021_01_06_425584 90 18 , , , 10_1101-2021_01_06_425584 90 19 feature feature VBP 10_1101-2021_01_06_425584 90 20 167 167 CD 10_1101-2021_01_06_425584 90 21 alignment alignment NN 10_1101-2021_01_06_425584 90 22 , , , 10_1101-2021_01_06_425584 90 23 and and CC 10_1101-2021_01_06_425584 90 24 gap gap NN 10_1101-2021_01_06_425584 90 25 - - HYPH 10_1101-2021_01_06_425584 90 26 filling filling NN 10_1101-2021_01_06_425584 90 27 ( ( -LRB- 10_1101-2021_01_06_425584 90 28 to to TO 10_1101-2021_01_06_425584 90 29 detect detect VB 10_1101-2021_01_06_425584 90 30 features feature NNS 10_1101-2021_01_06_425584 90 31 missed miss VBN 10_1101-2021_01_06_425584 90 32 during during IN 10_1101-2021_01_06_425584 90 33 the the DT 10_1101-2021_01_06_425584 90 34 initial initial JJ 10_1101-2021_01_06_425584 90 35 alignment alignment NN 10_1101-2021_01_06_425584 90 36 ) ) -RRB- 10_1101-2021_01_06_425584 90 37 from from IN 10_1101-2021_01_06_425584 90 38 LC LC NNP 10_1101-2021_01_06_425584 90 39 - - HYPH 10_1101-2021_01_06_425584 90 40 MS2 MS2 NNP 10_1101-2021_01_06_425584 90 41 168 168 CD 10_1101-2021_01_06_425584 90 42 datasets dataset NNS 10_1101-2021_01_06_425584 90 43 was be VBD 10_1101-2021_01_06_425584 90 44 performed perform VBN 10_1101-2021_01_06_425584 90 45 using use VBG 10_1101-2021_01_06_425584 90 46 XCMS XCMS NNP 10_1101-2021_01_06_425584 90 47 ( ( -LRB- 10_1101-2021_01_06_425584 90 48 https://xcmsonline.scripps.edu https://xcmsonline.scripps.edu NNP 10_1101-2021_01_06_425584 90 49 ) ) -RRB- 10_1101-2021_01_06_425584 90 50 ( ( -LRB- 10_1101-2021_01_06_425584 90 51 22 22 CD 10_1101-2021_01_06_425584 90 52 ) ) -RRB- 10_1101-2021_01_06_425584 90 53 and and CC 10_1101-2021_01_06_425584 90 54 MZmine MZmine NNP 10_1101-2021_01_06_425584 90 55 ( ( -LRB- 10_1101-2021_01_06_425584 90 56 23 23 CD 10_1101-2021_01_06_425584 90 57 ) ) -RRB- 10_1101-2021_01_06_425584 90 58 169 169 CD 10_1101-2021_01_06_425584 90 59 software software NN 10_1101-2021_01_06_425584 90 60 . . . 10_1101-2021_01_06_425584 91 1 The the DT 10_1101-2021_01_06_425584 91 2 XCMS XCMS NNP 10_1101-2021_01_06_425584 91 3 pipeline pipeline NN 10_1101-2021_01_06_425584 91 4 was be VBD 10_1101-2021_01_06_425584 91 5 used use VBN 10_1101-2021_01_06_425584 91 6 for for IN 10_1101-2021_01_06_425584 91 7 normalization normalization NN 10_1101-2021_01_06_425584 91 8 of of IN 10_1101-2021_01_06_425584 91 9 feature feature NN 10_1101-2021_01_06_425584 91 10 area area NN 10_1101-2021_01_06_425584 91 11 and and CC 10_1101-2021_01_06_425584 91 12 statistical statistical JJ 10_1101-2021_01_06_425584 91 13 analysis analysis NN 10_1101-2021_01_06_425584 91 14 . . . 10_1101-2021_01_06_425584 92 1 170 170 CD 10_1101-2021_01_06_425584 92 2 To to TO 10_1101-2021_01_06_425584 92 3 identify identify VB 10_1101-2021_01_06_425584 92 4 or or CC 10_1101-2021_01_06_425584 92 5 annotate annotate VB 10_1101-2021_01_06_425584 92 6 the the DT 10_1101-2021_01_06_425584 92 7 metabolites metabolite NNS 10_1101-2021_01_06_425584 92 8 at at IN 10_1101-2021_01_06_425584 92 9 the the DT 10_1101-2021_01_06_425584 92 10 chemical chemical NN 10_1101-2021_01_06_425584 92 11 structure structure NN 10_1101-2021_01_06_425584 92 12 and and CC 10_1101-2021_01_06_425584 92 13 class class NN 10_1101-2021_01_06_425584 92 14 level level NN 10_1101-2021_01_06_425584 92 15 , , , 10_1101-2021_01_06_425584 92 16 the the DT 10_1101-2021_01_06_425584 92 17 MS2 MS2 NNP 10_1101-2021_01_06_425584 92 18 - - HYPH 10_1101-2021_01_06_425584 92 19 171 171 NNP 10_1101-2021_01_06_425584 92 20 containing contain VBG 10_1101-2021_01_06_425584 92 21 features feature NNS 10_1101-2021_01_06_425584 92 22 extracted extract VBN 10_1101-2021_01_06_425584 92 23 with with IN 10_1101-2021_01_06_425584 92 24 MZmine MZmine NNP 10_1101-2021_01_06_425584 92 25 were be VBD 10_1101-2021_01_06_425584 92 26 further further RB 10_1101-2021_01_06_425584 92 27 analyzed analyze VBN 10_1101-2021_01_06_425584 92 28 using use VBG 10_1101-2021_01_06_425584 92 29 the the DT 10_1101-2021_01_06_425584 92 30 Global Global NNP 10_1101-2021_01_06_425584 92 31 Natural Natural NNP 10_1101-2021_01_06_425584 92 32 172 172 CD 10_1101-2021_01_06_425584 92 33 Products Products NNP 10_1101-2021_01_06_425584 92 34 Social Social NNP 10_1101-2021_01_06_425584 92 35 Molecular Molecular NNP 10_1101-2021_01_06_425584 92 36 Networking Networking NNP 10_1101-2021_01_06_425584 92 37 ( ( -LRB- 10_1101-2021_01_06_425584 92 38 GNPS GNPS NNP 10_1101-2021_01_06_425584 92 39 ) ) -RRB- 10_1101-2021_01_06_425584 92 40 ( ( -LRB- 10_1101-2021_01_06_425584 92 41 24 24 CD 10_1101-2021_01_06_425584 92 42 ) ) -RRB- 10_1101-2021_01_06_425584 92 43 , , , 10_1101-2021_01_06_425584 92 44 Network Network NNP 10_1101-2021_01_06_425584 92 45 Annotation Annotation NNP 10_1101-2021_01_06_425584 92 46 Propagation Propagation NNP 10_1101-2021_01_06_425584 92 47 ( ( -LRB- 10_1101-2021_01_06_425584 92 48 NAP NAP NNP 10_1101-2021_01_06_425584 92 49 ) ) -RRB- 10_1101-2021_01_06_425584 92 50 ( ( -LRB- 10_1101-2021_01_06_425584 92 51 25 25 CD 10_1101-2021_01_06_425584 92 52 ) ) -RRB- 10_1101-2021_01_06_425584 92 53 173 173 CD 10_1101-2021_01_06_425584 92 54 and and CC 10_1101-2021_01_06_425584 92 55 MS2LDA MS2LDA NNP 10_1101-2021_01_06_425584 92 56 ( ( -LRB- 10_1101-2021_01_06_425584 92 57 26 26 CD 10_1101-2021_01_06_425584 92 58 ) ) -RRB- 10_1101-2021_01_06_425584 92 59 in in IN 10_1101-2021_01_06_425584 92 60 silico silico NN 10_1101-2021_01_06_425584 92 61 annotation annotation NN 10_1101-2021_01_06_425584 92 62 tools tool NNS 10_1101-2021_01_06_425584 92 63 , , , 10_1101-2021_01_06_425584 92 64 and and CC 10_1101-2021_01_06_425584 92 65 Classyfire Classyfire NNP 10_1101-2021_01_06_425584 92 66 automated automate VBD 10_1101-2021_01_06_425584 92 67 chemical chemical NN 10_1101-2021_01_06_425584 92 68 classification classification NN 10_1101-2021_01_06_425584 92 69 ( ( -LRB- 10_1101-2021_01_06_425584 92 70 27 27 CD 10_1101-2021_01_06_425584 92 71 ) ) -RRB- 10_1101-2021_01_06_425584 92 72 , , , 10_1101-2021_01_06_425584 92 73 174 174 CD 10_1101-2021_01_06_425584 92 74 as as RB 10_1101-2021_01_06_425584 92 75 previously previously RB 10_1101-2021_01_06_425584 92 76 described describe VBN 10_1101-2021_01_06_425584 92 77 ( ( -LRB- 10_1101-2021_01_06_425584 92 78 21 21 CD 10_1101-2021_01_06_425584 92 79 ) ) -RRB- 10_1101-2021_01_06_425584 92 80 with with IN 10_1101-2021_01_06_425584 92 81 some some DT 10_1101-2021_01_06_425584 92 82 modifications modification NNS 10_1101-2021_01_06_425584 92 83 . . . 10_1101-2021_01_06_425584 93 1 The the DT 10_1101-2021_01_06_425584 93 2 confidences confidence NNS 10_1101-2021_01_06_425584 93 3 of of IN 10_1101-2021_01_06_425584 93 4 such such JJ 10_1101-2021_01_06_425584 93 5 annotations annotation NNS 10_1101-2021_01_06_425584 93 6 are be VBP 10_1101-2021_01_06_425584 93 7 175 175 CD 10_1101-2021_01_06_425584 93 8 level level NN 10_1101-2021_01_06_425584 93 9 2 2 CD 10_1101-2021_01_06_425584 93 10 ( ( -LRB- 10_1101-2021_01_06_425584 93 11 probable probable JJ 10_1101-2021_01_06_425584 93 12 structure structure NN 10_1101-2021_01_06_425584 93 13 by by IN 10_1101-2021_01_06_425584 93 14 library library NN 10_1101-2021_01_06_425584 93 15 spectrum spectrum NN 10_1101-2021_01_06_425584 93 16 match match NN 10_1101-2021_01_06_425584 93 17 ) ) -RRB- 10_1101-2021_01_06_425584 93 18 and and CC 10_1101-2021_01_06_425584 93 19 level level NN 10_1101-2021_01_06_425584 93 20 3 3 CD 10_1101-2021_01_06_425584 93 21 ( ( -LRB- 10_1101-2021_01_06_425584 93 22 tentative tentative JJ 10_1101-2021_01_06_425584 93 23 candidates candidate NNS 10_1101-2021_01_06_425584 93 24 ) ) -RRB- 10_1101-2021_01_06_425584 93 25 in in IN 10_1101-2021_01_06_425584 93 26 176 176 CD 10_1101-2021_01_06_425584 93 27 agreement agreement NN 10_1101-2021_01_06_425584 93 28 with with IN 10_1101-2021_01_06_425584 93 29 the the DT 10_1101-2021_01_06_425584 93 30 Metabolomics Metabolomics NNPS 10_1101-2021_01_06_425584 93 31 Standards Standards NNPS 10_1101-2021_01_06_425584 93 32 Initiative Initiative NNP 10_1101-2021_01_06_425584 93 33 ( ( -LRB- 10_1101-2021_01_06_425584 93 34 MSI MSI NNP 10_1101-2021_01_06_425584 93 35 ) ) -RRB- 10_1101-2021_01_06_425584 93 36 classification classification NN 10_1101-2021_01_06_425584 93 37 ( ( -LRB- 10_1101-2021_01_06_425584 93 38 28 28 CD 10_1101-2021_01_06_425584 93 39 ) ) -RRB- 10_1101-2021_01_06_425584 93 40 . . . 10_1101-2021_01_06_425584 94 1 Molecular molecular JJ 10_1101-2021_01_06_425584 94 2 177 177 CD 10_1101-2021_01_06_425584 94 3 networking networking NN 10_1101-2021_01_06_425584 94 4 , , , 10_1101-2021_01_06_425584 94 5 NAP NAP NNP 10_1101-2021_01_06_425584 94 6 , , , 10_1101-2021_01_06_425584 94 7 and and CC 10_1101-2021_01_06_425584 94 8 Classyfire Classyfire NNP 10_1101-2021_01_06_425584 94 9 outputs output NNS 10_1101-2021_01_06_425584 94 10 were be VBD 10_1101-2021_01_06_425584 94 11 integrated integrate VBN 10_1101-2021_01_06_425584 94 12 using use VBG 10_1101-2021_01_06_425584 94 13 the the DT 10_1101-2021_01_06_425584 94 14 MolNetEnhancer MolNetEnhancer NNP 10_1101-2021_01_06_425584 94 15 workflow workflow NN 10_1101-2021_01_06_425584 94 16 178 178 CD 10_1101-2021_01_06_425584 94 17 ( ( -LRB- 10_1101-2021_01_06_425584 94 18 29 29 CD 10_1101-2021_01_06_425584 94 19 ) ) -RRB- 10_1101-2021_01_06_425584 94 20 . . . 10_1101-2021_01_06_425584 95 1 Molecular molecular JJ 10_1101-2021_01_06_425584 95 2 networks network NNS 10_1101-2021_01_06_425584 95 3 were be VBD 10_1101-2021_01_06_425584 95 4 visualized visualize VBN 10_1101-2021_01_06_425584 95 5 using use VBG 10_1101-2021_01_06_425584 95 6 Cytoscape Cytoscape NNP 10_1101-2021_01_06_425584 95 7 version version NN 10_1101-2021_01_06_425584 95 8 3.8.2 3.8.2 CD 10_1101-2021_01_06_425584 95 9 ( ( -LRB- 10_1101-2021_01_06_425584 95 10 30 30 CD 10_1101-2021_01_06_425584 95 11 ) ) -RRB- 10_1101-2021_01_06_425584 95 12 . . . 10_1101-2021_01_06_425584 96 1 In in IN 10_1101-2021_01_06_425584 96 2 addition addition NN 10_1101-2021_01_06_425584 96 3 , , , 10_1101-2021_01_06_425584 96 4 179 179 CD 10_1101-2021_01_06_425584 96 5 chemical chemical NN 10_1101-2021_01_06_425584 96 6 substructures substructure NNS 10_1101-2021_01_06_425584 96 7 ( ( -LRB- 10_1101-2021_01_06_425584 96 8 co co JJ 10_1101-2021_01_06_425584 96 9 - - JJ 10_1101-2021_01_06_425584 96 10 occurring occurring JJ 10_1101-2021_01_06_425584 96 11 fragments fragment NNS 10_1101-2021_01_06_425584 96 12 and and CC 10_1101-2021_01_06_425584 96 13 neutral neutral JJ 10_1101-2021_01_06_425584 96 14 losses loss NNS 10_1101-2021_01_06_425584 96 15 referred refer VBD 10_1101-2021_01_06_425584 96 16 to to IN 10_1101-2021_01_06_425584 96 17 as as IN 10_1101-2021_01_06_425584 96 18 “ " `` 10_1101-2021_01_06_425584 96 19 mass2motifs mass2motifs NNP 10_1101-2021_01_06_425584 96 20 ” " '' 10_1101-2021_01_06_425584 96 21 180 180 CD 10_1101-2021_01_06_425584 96 22 [ [ -LRB- 10_1101-2021_01_06_425584 96 23 M2 M2 NNP 10_1101-2021_01_06_425584 96 24 M M NNP 10_1101-2021_01_06_425584 96 25 ] ] -RRB- 10_1101-2021_01_06_425584 96 26 ) ) -RRB- 10_1101-2021_01_06_425584 96 27 were be VBD 10_1101-2021_01_06_425584 96 28 recognized recognize VBN 10_1101-2021_01_06_425584 96 29 using use VBG 10_1101-2021_01_06_425584 96 30 the the DT 10_1101-2021_01_06_425584 96 31 MS2LDA MS2LDA NNP 10_1101-2021_01_06_425584 96 32 web web NN 10_1101-2021_01_06_425584 96 33 pipeline pipeline NN 10_1101-2021_01_06_425584 96 34 ( ( -LRB- 10_1101-2021_01_06_425584 96 35 http://www.ms2lda.org http://www.ms2lda.org NNP 10_1101-2021_01_06_425584 96 36 ) ) -RRB- 10_1101-2021_01_06_425584 96 37 to to IN 10_1101-2021_01_06_425584 96 38 further further VB 10_1101-2021_01_06_425584 96 39 181 181 CD 10_1101-2021_01_06_425584 96 40 annotate annotate JJ 10_1101-2021_01_06_425584 96 41 metabolites metabolite NNS 10_1101-2021_01_06_425584 96 42 ( ( -LRB- 10_1101-2021_01_06_425584 96 43 level level NN 10_1101-2021_01_06_425584 96 44 3 3 CD 10_1101-2021_01_06_425584 96 45 , , , 10_1101-2021_01_06_425584 96 46 MSI MSI NNP 10_1101-2021_01_06_425584 96 47 ) ) -RRB- 10_1101-2021_01_06_425584 96 48 . . . 10_1101-2021_01_06_425584 97 1 The the DT 10_1101-2021_01_06_425584 97 2 detailed detailed JJ 10_1101-2021_01_06_425584 97 3 processing processing NN 10_1101-2021_01_06_425584 97 4 parameters parameter NNS 10_1101-2021_01_06_425584 97 5 for for IN 10_1101-2021_01_06_425584 97 6 XCMS XCMS NNP 10_1101-2021_01_06_425584 97 7 and and CC 10_1101-2021_01_06_425584 97 8 MZmine MZmine NNP 10_1101-2021_01_06_425584 97 9 182 182 CD 10_1101-2021_01_06_425584 97 10 pipelines pipeline NNS 10_1101-2021_01_06_425584 97 11 are be VBP 10_1101-2021_01_06_425584 97 12 found find VBN 10_1101-2021_01_06_425584 97 13 in in IN 10_1101-2021_01_06_425584 97 14 the the DT 10_1101-2021_01_06_425584 97 15 supporting support VBG 10_1101-2021_01_06_425584 97 16 information information NN 10_1101-2021_01_06_425584 97 17 . . . 10_1101-2021_01_06_425584 98 1 183 183 CD 10_1101-2021_01_06_425584 98 2 184 184 CD 10_1101-2021_01_06_425584 98 3 .CC .CC : 10_1101-2021_01_06_425584 98 4 - - HYPH 10_1101-2021_01_06_425584 98 5 BY by IN 10_1101-2021_01_06_425584 98 6 - - HYPH 10_1101-2021_01_06_425584 98 7 NC NC NNP 10_1101-2021_01_06_425584 98 8 - - HYPH 10_1101-2021_01_06_425584 98 9 ND ND NNP 10_1101-2021_01_06_425584 98 10 4.0 4.0 CD 10_1101-2021_01_06_425584 98 11 International International NNP 10_1101-2021_01_06_425584 98 12 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 98 13 under under IN 10_1101-2021_01_06_425584 98 14 a a DT 10_1101-2021_01_06_425584 98 15 ( ( -LRB- 10_1101-2021_01_06_425584 98 16 which which WDT 10_1101-2021_01_06_425584 98 17 was be VBD 10_1101-2021_01_06_425584 98 18 not not RB 10_1101-2021_01_06_425584 98 19 certified certify VBN 10_1101-2021_01_06_425584 98 20 by by IN 10_1101-2021_01_06_425584 98 21 peer peer NN 10_1101-2021_01_06_425584 98 22 review review NN 10_1101-2021_01_06_425584 98 23 ) ) -RRB- 10_1101-2021_01_06_425584 98 24 is be VBZ 10_1101-2021_01_06_425584 98 25 the the DT 10_1101-2021_01_06_425584 98 26 author author NN 10_1101-2021_01_06_425584 98 27 / / SYM 10_1101-2021_01_06_425584 98 28 funder funder NN 10_1101-2021_01_06_425584 98 29 , , , 10_1101-2021_01_06_425584 98 30 who who WP 10_1101-2021_01_06_425584 98 31 has have VBZ 10_1101-2021_01_06_425584 98 32 granted grant VBN 10_1101-2021_01_06_425584 98 33 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 98 34 a a DT 10_1101-2021_01_06_425584 98 35 license license NN 10_1101-2021_01_06_425584 98 36 to to TO 10_1101-2021_01_06_425584 98 37 display display VB 10_1101-2021_01_06_425584 98 38 the the DT 10_1101-2021_01_06_425584 98 39 preprint preprint NN 10_1101-2021_01_06_425584 98 40 in in IN 10_1101-2021_01_06_425584 98 41 perpetuity perpetuity NN 10_1101-2021_01_06_425584 98 42 . . . 10_1101-2021_01_06_425584 99 1 It -PRON- PRP 10_1101-2021_01_06_425584 99 2 is be VBZ 10_1101-2021_01_06_425584 99 3 made make VBN 10_1101-2021_01_06_425584 99 4 The the DT 10_1101-2021_01_06_425584 99 5 copyright copyright NN 10_1101-2021_01_06_425584 99 6 holder holder NN 10_1101-2021_01_06_425584 99 7 for for IN 10_1101-2021_01_06_425584 99 8 this this DT 10_1101-2021_01_06_425584 99 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 99 10 version version NN 10_1101-2021_01_06_425584 99 11 posted post VBD 10_1101-2021_01_06_425584 99 12 January January NNP 10_1101-2021_01_06_425584 99 13 8 8 CD 10_1101-2021_01_06_425584 99 14 , , , 10_1101-2021_01_06_425584 99 15 2021 2021 CD 10_1101-2021_01_06_425584 99 16 . . . 10_1101-2021_01_06_425584 99 17 ; ; : 10_1101-2021_01_06_425584 99 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 99 19 : : : 10_1101-2021_01_06_425584 99 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 99 21 preprint preprint NN 10_1101-2021_01_06_425584 99 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 99 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 99 24 7 7 CD 10_1101-2021_01_06_425584 99 25 2.7 2.7 CD 10_1101-2021_01_06_425584 99 26 Peptidomics Peptidomics NNP 10_1101-2021_01_06_425584 99 27 data datum NNS 10_1101-2021_01_06_425584 99 28 processing process VBG 10_1101-2021_01_06_425584 99 29 185 185 CD 10_1101-2021_01_06_425584 99 30 For for IN 10_1101-2021_01_06_425584 99 31 peptide peptide JJ 10_1101-2021_01_06_425584 99 32 identification identification NN 10_1101-2021_01_06_425584 99 33 , , , 10_1101-2021_01_06_425584 99 34 raw raw JJ 10_1101-2021_01_06_425584 99 35 .wiff .wiff NN 10_1101-2021_01_06_425584 99 36 and and CC 10_1101-2021_01_06_425584 99 37 .wiff.scan .wiff.scan JJ 10_1101-2021_01_06_425584 99 38 files file NNS 10_1101-2021_01_06_425584 99 39 ( ( -LRB- 10_1101-2021_01_06_425584 99 40 same same JJ 10_1101-2021_01_06_425584 99 41 files file NNS 10_1101-2021_01_06_425584 99 42 used use VBN 10_1101-2021_01_06_425584 99 43 for for IN 10_1101-2021_01_06_425584 99 44 MZmine MZmine NNP 10_1101-2021_01_06_425584 99 45 and and CC 10_1101-2021_01_06_425584 99 46 XCMS XCMS NNP 10_1101-2021_01_06_425584 99 47 ) ) -RRB- 10_1101-2021_01_06_425584 99 48 186 186 CD 10_1101-2021_01_06_425584 99 49 from from IN 10_1101-2021_01_06_425584 99 50 the the DT 10_1101-2021_01_06_425584 99 51 experimental experimental JJ 10_1101-2021_01_06_425584 99 52 and and CC 10_1101-2021_01_06_425584 99 53 control control NN 10_1101-2021_01_06_425584 99 54 groups group NNS 10_1101-2021_01_06_425584 99 55 were be VBD 10_1101-2021_01_06_425584 99 56 analyzed analyze VBN 10_1101-2021_01_06_425584 99 57 separately separately RB 10_1101-2021_01_06_425584 99 58 using use VBG 10_1101-2021_01_06_425584 99 59 ProteinPilot ProteinPilot NNP 10_1101-2021_01_06_425584 99 60 software software NN 10_1101-2021_01_06_425584 99 61 187 187 CD 10_1101-2021_01_06_425584 99 62 version version NN 10_1101-2021_01_06_425584 99 63 4.2 4.2 CD 10_1101-2021_01_06_425584 99 64 ( ( -LRB- 10_1101-2021_01_06_425584 99 65 Ab Ab NNP 10_1101-2021_01_06_425584 99 66 Sciex Sciex NNP 10_1101-2021_01_06_425584 99 67 , , , 10_1101-2021_01_06_425584 99 68 Foster Foster NNP 10_1101-2021_01_06_425584 99 69 City City NNP 10_1101-2021_01_06_425584 99 70 , , , 10_1101-2021_01_06_425584 99 71 CA CA NNP 10_1101-2021_01_06_425584 99 72 , , , 10_1101-2021_01_06_425584 99 73 USA USA NNP 10_1101-2021_01_06_425584 99 74 ) ) -RRB- 10_1101-2021_01_06_425584 99 75 with with IN 10_1101-2021_01_06_425584 99 76 the the DT 10_1101-2021_01_06_425584 99 77 Paragon Paragon NNP 10_1101-2021_01_06_425584 99 78 algorithm algorithm NN 10_1101-2021_01_06_425584 99 79 . . . 10_1101-2021_01_06_425584 100 1 MS1 MS1 NNP 10_1101-2021_01_06_425584 100 2 and and CC 10_1101-2021_01_06_425584 100 3 MS2 MS2 NNP 10_1101-2021_01_06_425584 100 4 data datum NNS 10_1101-2021_01_06_425584 100 5 were be VBD 10_1101-2021_01_06_425584 100 6 188 188 CD 10_1101-2021_01_06_425584 100 7 searched search VBN 10_1101-2021_01_06_425584 100 8 against against IN 10_1101-2021_01_06_425584 100 9 the the DT 10_1101-2021_01_06_425584 100 10 Bos Bos NNP 10_1101-2021_01_06_425584 100 11 taurus taurus CD 10_1101-2021_01_06_425584 100 12 SwissProt SwissProt NNP 10_1101-2021_01_06_425584 100 13 sequence sequence NN 10_1101-2021_01_06_425584 100 14 database database NN 10_1101-2021_01_06_425584 100 15 ( ( -LRB- 10_1101-2021_01_06_425584 100 16 6006 6006 CD 10_1101-2021_01_06_425584 100 17 reviewed review VBD 10_1101-2021_01_06_425584 100 18 189 189 CD 10_1101-2021_01_06_425584 100 19 proteins+common proteins+common NNP 10_1101-2021_01_06_425584 100 20 protein protein NN 10_1101-2021_01_06_425584 100 21 contaminants contaminant NNS 10_1101-2021_01_06_425584 100 22 , , , 10_1101-2021_01_06_425584 100 23 February February NNP 10_1101-2021_01_06_425584 100 24 2019 2019 CD 10_1101-2021_01_06_425584 100 25 release release NN 10_1101-2021_01_06_425584 100 26 ) ) -RRB- 10_1101-2021_01_06_425584 100 27 . . . 10_1101-2021_01_06_425584 101 1 The the DT 10_1101-2021_01_06_425584 101 2 parameters parameter NNS 10_1101-2021_01_06_425584 101 3 input input NN 10_1101-2021_01_06_425584 101 4 was be VBD 10_1101-2021_01_06_425584 101 5 : : : 10_1101-2021_01_06_425584 101 6 190 190 CD 10_1101-2021_01_06_425584 101 7 sample sample NN 10_1101-2021_01_06_425584 101 8 type type NN 10_1101-2021_01_06_425584 101 9 , , , 10_1101-2021_01_06_425584 101 10 identification identification NN 10_1101-2021_01_06_425584 101 11 ; ; : 10_1101-2021_01_06_425584 101 12 digestion digestion NN 10_1101-2021_01_06_425584 101 13 , , , 10_1101-2021_01_06_425584 101 14 none none NN 10_1101-2021_01_06_425584 101 15 ; ; : 10_1101-2021_01_06_425584 101 16 Cys cys NN 10_1101-2021_01_06_425584 101 17 alkylation alkylation NN 10_1101-2021_01_06_425584 101 18 , , , 10_1101-2021_01_06_425584 101 19 none none NN 10_1101-2021_01_06_425584 101 20 ; ; , 10_1101-2021_01_06_425584 101 21 instrument instrument NN 10_1101-2021_01_06_425584 101 22 , , , 10_1101-2021_01_06_425584 101 23 TripleTOF TripleTOF NNP 10_1101-2021_01_06_425584 101 24 5600 5600 CD 10_1101-2021_01_06_425584 101 25 ; ; : 10_1101-2021_01_06_425584 101 26 191 191 CD 10_1101-2021_01_06_425584 101 27 special special JJ 10_1101-2021_01_06_425584 101 28 factors factor NNS 10_1101-2021_01_06_425584 101 29 , , , 10_1101-2021_01_06_425584 101 30 none none NN 10_1101-2021_01_06_425584 101 31 ; ; : 10_1101-2021_01_06_425584 101 32 species specie NNS 10_1101-2021_01_06_425584 101 33 , , , 10_1101-2021_01_06_425584 101 34 Bos Bos NNP 10_1101-2021_01_06_425584 101 35 taurus taurus NNP 10_1101-2021_01_06_425584 101 36 ; ; : 10_1101-2021_01_06_425584 101 37 ID ID NNP 10_1101-2021_01_06_425584 101 38 focus focus VBP 10_1101-2021_01_06_425584 101 39 , , , 10_1101-2021_01_06_425584 101 40 biological biological JJ 10_1101-2021_01_06_425584 101 41 modifications modification NNS 10_1101-2021_01_06_425584 101 42 , , , 10_1101-2021_01_06_425584 101 43 and and CC 10_1101-2021_01_06_425584 101 44 amino amino NN 10_1101-2021_01_06_425584 101 45 acid acid NN 10_1101-2021_01_06_425584 101 46 192 192 CD 10_1101-2021_01_06_425584 101 47 substitutions substitution NNS 10_1101-2021_01_06_425584 101 48 ; ; : 10_1101-2021_01_06_425584 101 49 search search NN 10_1101-2021_01_06_425584 101 50 effort effort NN 10_1101-2021_01_06_425584 101 51 , , , 10_1101-2021_01_06_425584 101 52 thorough thorough JJ 10_1101-2021_01_06_425584 101 53 ID ID NNP 10_1101-2021_01_06_425584 101 54 . . . 10_1101-2021_01_06_425584 102 1 False false JJ 10_1101-2021_01_06_425584 102 2 discovery discovery NN 10_1101-2021_01_06_425584 102 3 rate rate NN 10_1101-2021_01_06_425584 102 4 analysis analysis NN 10_1101-2021_01_06_425584 102 5 was be VBD 10_1101-2021_01_06_425584 102 6 also also RB 10_1101-2021_01_06_425584 102 7 performed perform VBN 10_1101-2021_01_06_425584 102 8 . . . 10_1101-2021_01_06_425584 103 1 All all DT 10_1101-2021_01_06_425584 103 2 193 193 CD 10_1101-2021_01_06_425584 103 3 peptides peptide NNS 10_1101-2021_01_06_425584 103 4 were be VBD 10_1101-2021_01_06_425584 103 5 exported export VBN 10_1101-2021_01_06_425584 103 6 and and CC 10_1101-2021_01_06_425584 103 7 those those DT 10_1101-2021_01_06_425584 103 8 with with IN 10_1101-2021_01_06_425584 103 9 a a DT 10_1101-2021_01_06_425584 103 10 > > XX 10_1101-2021_01_06_425584 103 11 90 90 CD 10_1101-2021_01_06_425584 103 12 % % NN 10_1101-2021_01_06_425584 103 13 confidence confidence NN 10_1101-2021_01_06_425584 103 14 were be VBD 10_1101-2021_01_06_425584 103 15 linked link VBN 10_1101-2021_01_06_425584 103 16 to to IN 10_1101-2021_01_06_425584 103 17 the the DT 10_1101-2021_01_06_425584 103 18 corresponding corresponding JJ 10_1101-2021_01_06_425584 103 19 194 194 CD 10_1101-2021_01_06_425584 103 20 feature feature NN 10_1101-2021_01_06_425584 103 21 extracted extract VBN 10_1101-2021_01_06_425584 103 22 by by IN 10_1101-2021_01_06_425584 103 23 the the DT 10_1101-2021_01_06_425584 103 24 XCMS XCMS NNP 10_1101-2021_01_06_425584 103 25 algorithm algorithm NN 10_1101-2021_01_06_425584 103 26 using use VBG 10_1101-2021_01_06_425584 103 27 their -PRON- PRP$ 10_1101-2021_01_06_425584 103 28 accurate accurate JJ 10_1101-2021_01_06_425584 103 29 mass mass NN 10_1101-2021_01_06_425584 103 30 and and CC 10_1101-2021_01_06_425584 103 31 retention retention NN 10_1101-2021_01_06_425584 103 32 time time NN 10_1101-2021_01_06_425584 103 33 195 195 CD 10_1101-2021_01_06_425584 103 34 information information NN 10_1101-2021_01_06_425584 103 35 . . . 10_1101-2021_01_06_425584 104 1 For for IN 10_1101-2021_01_06_425584 104 2 peptide peptide JJ 10_1101-2021_01_06_425584 104 3 quantification quantification NN 10_1101-2021_01_06_425584 104 4 , , , 10_1101-2021_01_06_425584 104 5 we -PRON- PRP 10_1101-2021_01_06_425584 104 6 employed employ VBD 10_1101-2021_01_06_425584 104 7 the the DT 10_1101-2021_01_06_425584 104 8 normalized normalized JJ 10_1101-2021_01_06_425584 104 9 feature feature NN 10_1101-2021_01_06_425584 104 10 abundances abundance NNS 10_1101-2021_01_06_425584 104 11 ( ( -LRB- 10_1101-2021_01_06_425584 104 12 MS1 MS1 NNP 10_1101-2021_01_06_425584 104 13 196 196 CD 10_1101-2021_01_06_425584 104 14 level level NN 10_1101-2021_01_06_425584 104 15 ) ) -RRB- 10_1101-2021_01_06_425584 104 16 generated generate VBN 10_1101-2021_01_06_425584 104 17 by by IN 10_1101-2021_01_06_425584 104 18 XCMS XCMS NNP 10_1101-2021_01_06_425584 104 19 . . . 10_1101-2021_01_06_425584 105 1 A a DT 10_1101-2021_01_06_425584 105 2 significance significance NN 10_1101-2021_01_06_425584 105 3 threshold threshold NN 10_1101-2021_01_06_425584 105 4 of of IN 10_1101-2021_01_06_425584 105 5 p<0.05 p<0.05 JJ 10_1101-2021_01_06_425584 105 6 ( ( -LRB- 10_1101-2021_01_06_425584 105 7 Welch Welch NNP 10_1101-2021_01_06_425584 105 8 ’s ’s POS 10_1101-2021_01_06_425584 105 9 t t NN 10_1101-2021_01_06_425584 105 10 test test NN 10_1101-2021_01_06_425584 105 11 ) ) -RRB- 10_1101-2021_01_06_425584 105 12 was be VBD 10_1101-2021_01_06_425584 105 13 utilized utilize VBN 10_1101-2021_01_06_425584 105 14 . . . 10_1101-2021_01_06_425584 106 1 197 197 CD 10_1101-2021_01_06_425584 106 2 198 198 CD 10_1101-2021_01_06_425584 106 3 2.8 2.8 CD 10_1101-2021_01_06_425584 106 4 Proteomics Proteomics NNP 10_1101-2021_01_06_425584 106 5 data datum NNS 10_1101-2021_01_06_425584 106 6 reprocessing reprocess VBG 10_1101-2021_01_06_425584 106 7 199 199 CD 10_1101-2021_01_06_425584 106 8 The the DT 10_1101-2021_01_06_425584 106 9 SWATH SWATH NNP 10_1101-2021_01_06_425584 106 10 - - HYPH 10_1101-2021_01_06_425584 106 11 based base VBN 10_1101-2021_01_06_425584 106 12 proteomics proteomic NNS 10_1101-2021_01_06_425584 106 13 data datum NNS 10_1101-2021_01_06_425584 106 14 ( ( -LRB- 10_1101-2021_01_06_425584 106 15 identifier identifier NNP 10_1101-2021_01_06_425584 106 16 PXD013643 PXD013643 NNP 10_1101-2021_01_06_425584 106 17 ) ) -RRB- 10_1101-2021_01_06_425584 106 18 , , , 10_1101-2021_01_06_425584 106 19 hosted host VBN 10_1101-2021_01_06_425584 106 20 in in IN 10_1101-2021_01_06_425584 106 21 ProteomeXchange ProteomeXchange NNP 10_1101-2021_01_06_425584 106 22 200 200 CD 10_1101-2021_01_06_425584 106 23 consortium consortium NN 10_1101-2021_01_06_425584 106 24 via via IN 10_1101-2021_01_06_425584 106 25 PRIDE PRIDE NNP 10_1101-2021_01_06_425584 106 26 ( ( -LRB- 10_1101-2021_01_06_425584 106 27 31 31 CD 10_1101-2021_01_06_425584 106 28 ) ) -RRB- 10_1101-2021_01_06_425584 106 29 , , , 10_1101-2021_01_06_425584 106 30 was be VBD 10_1101-2021_01_06_425584 106 31 reanalyzed reanalyze VBN 10_1101-2021_01_06_425584 106 32 with with IN 10_1101-2021_01_06_425584 106 33 some some DT 10_1101-2021_01_06_425584 106 34 modifications modification NNS 10_1101-2021_01_06_425584 106 35 . . . 10_1101-2021_01_06_425584 107 1 The the DT 10_1101-2021_01_06_425584 107 2 parameters parameter NNS 10_1101-2021_01_06_425584 107 3 used use VBD 10_1101-2021_01_06_425584 107 4 to to IN 10_1101-2021_01_06_425584 107 5 201 201 CD 10_1101-2021_01_06_425584 107 6 build build VB 10_1101-2021_01_06_425584 107 7 the the DT 10_1101-2021_01_06_425584 107 8 spectral spectral JJ 10_1101-2021_01_06_425584 107 9 library library NN 10_1101-2021_01_06_425584 107 10 remained remain VBD 10_1101-2021_01_06_425584 107 11 the the DT 10_1101-2021_01_06_425584 107 12 same same JJ 10_1101-2021_01_06_425584 107 13 ( ( -LRB- 10_1101-2021_01_06_425584 107 14 15 15 CD 10_1101-2021_01_06_425584 107 15 ) ) -RRB- 10_1101-2021_01_06_425584 107 16 , , , 10_1101-2021_01_06_425584 107 17 while while IN 10_1101-2021_01_06_425584 107 18 the the DT 10_1101-2021_01_06_425584 107 19 parameter parameter NN 10_1101-2021_01_06_425584 107 20 for for IN 10_1101-2021_01_06_425584 107 21 peptides peptide NNS 10_1101-2021_01_06_425584 107 22 per per IN 10_1101-2021_01_06_425584 107 23 protein protein NN 10_1101-2021_01_06_425584 107 24 202 202 CD 10_1101-2021_01_06_425584 107 25 was be VBD 10_1101-2021_01_06_425584 107 26 set set VBN 10_1101-2021_01_06_425584 107 27 to to IN 10_1101-2021_01_06_425584 107 28 100 100 CD 10_1101-2021_01_06_425584 107 29 in in IN 10_1101-2021_01_06_425584 107 30 the the DT 10_1101-2021_01_06_425584 107 31 software software NN 10_1101-2021_01_06_425584 107 32 SWATH SWATH NNP 10_1101-2021_01_06_425584 107 33 ® ® NNPS 10_1101-2021_01_06_425584 107 34 Acquisition Acquisition NNP 10_1101-2021_01_06_425584 107 35 MicroApp MicroApp NNP 10_1101-2021_01_06_425584 107 36 2.0 2.0 CD 10_1101-2021_01_06_425584 107 37 in in IN 10_1101-2021_01_06_425584 107 38 PeakView PeakView NNP 10_1101-2021_01_06_425584 107 39 ® ® NNP 10_1101-2021_01_06_425584 107 40 version version NN 10_1101-2021_01_06_425584 107 41 1.2 1.2 CD 10_1101-2021_01_06_425584 107 42 ( ( -LRB- 10_1101-2021_01_06_425584 107 43 AB AB NNP 10_1101-2021_01_06_425584 107 44 203 203 CD 10_1101-2021_01_06_425584 107 45 Sciex Sciex NNP 10_1101-2021_01_06_425584 107 46 , , , 10_1101-2021_01_06_425584 107 47 Foster Foster NNP 10_1101-2021_01_06_425584 107 48 City City NNP 10_1101-2021_01_06_425584 107 49 , , , 10_1101-2021_01_06_425584 107 50 CA CA NNP 10_1101-2021_01_06_425584 107 51 , , , 10_1101-2021_01_06_425584 107 52 USA USA NNP 10_1101-2021_01_06_425584 107 53 ) ) -RRB- 10_1101-2021_01_06_425584 107 54 . . . 10_1101-2021_01_06_425584 108 1 The the DT 10_1101-2021_01_06_425584 108 2 obtained obtain VBN 10_1101-2021_01_06_425584 108 3 protein protein NN 10_1101-2021_01_06_425584 108 4 peak peak NN 10_1101-2021_01_06_425584 108 5 areas area NNS 10_1101-2021_01_06_425584 108 6 were be VBD 10_1101-2021_01_06_425584 108 7 exported export VBN 10_1101-2021_01_06_425584 108 8 to to TO 10_1101-2021_01_06_425584 108 9 Markerview Markerview NNP 10_1101-2021_01_06_425584 108 10 ™ ™ CD 10_1101-2021_01_06_425584 108 11 204 204 CD 10_1101-2021_01_06_425584 108 12 version version NN 10_1101-2021_01_06_425584 108 13 1.3 1.3 CD 10_1101-2021_01_06_425584 108 14 ( ( -LRB- 10_1101-2021_01_06_425584 108 15 AB AB NNP 10_1101-2021_01_06_425584 108 16 Sciex Sciex NNP 10_1101-2021_01_06_425584 108 17 , , , 10_1101-2021_01_06_425584 108 18 Foster Foster NNP 10_1101-2021_01_06_425584 108 19 City City NNP 10_1101-2021_01_06_425584 108 20 , , , 10_1101-2021_01_06_425584 108 21 CA CA NNP 10_1101-2021_01_06_425584 108 22 , , , 10_1101-2021_01_06_425584 108 23 USA USA NNP 10_1101-2021_01_06_425584 108 24 ) ) -RRB- 10_1101-2021_01_06_425584 108 25 for for IN 10_1101-2021_01_06_425584 108 26 further further JJ 10_1101-2021_01_06_425584 108 27 data datum NNS 10_1101-2021_01_06_425584 108 28 refinement refinement NN 10_1101-2021_01_06_425584 108 29 , , , 10_1101-2021_01_06_425584 108 30 including include VBG 10_1101-2021_01_06_425584 108 31 assignment assignment NN 10_1101-2021_01_06_425584 108 32 of of IN 10_1101-2021_01_06_425584 108 33 205 205 CD 10_1101-2021_01_06_425584 108 34 IDs id NNS 10_1101-2021_01_06_425584 108 35 to to IN 10_1101-2021_01_06_425584 108 36 files file NNS 10_1101-2021_01_06_425584 108 37 and and CC 10_1101-2021_01_06_425584 108 38 removal removal NN 10_1101-2021_01_06_425584 108 39 of of IN 10_1101-2021_01_06_425584 108 40 reversed reversed JJ 10_1101-2021_01_06_425584 108 41 and and CC 10_1101-2021_01_06_425584 108 42 common common JJ 10_1101-2021_01_06_425584 108 43 contaminants contaminant NNS 10_1101-2021_01_06_425584 108 44 . . . 10_1101-2021_01_06_425584 109 1 Peak peak NN 10_1101-2021_01_06_425584 109 2 areas area NNS 10_1101-2021_01_06_425584 109 3 were be VBD 10_1101-2021_01_06_425584 109 4 exported export VBN 10_1101-2021_01_06_425584 109 5 in in IN 10_1101-2021_01_06_425584 109 6 a a DT 10_1101-2021_01_06_425584 109 7 206 206 CD 10_1101-2021_01_06_425584 109 8 .tsv .tsv CD 10_1101-2021_01_06_425584 109 9 file file NN 10_1101-2021_01_06_425584 109 10 , , , 10_1101-2021_01_06_425584 109 11 and and CC 10_1101-2021_01_06_425584 109 12 normalized normalize VBD 10_1101-2021_01_06_425584 109 13 with with IN 10_1101-2021_01_06_425584 109 14 NormalyzerDE NormalyzerDE NNP 10_1101-2021_01_06_425584 109 15 online online JJ 10_1101-2021_01_06_425584 109 16 version version NN 10_1101-2021_01_06_425584 109 17 1.3.4 1.3.4 CD 10_1101-2021_01_06_425584 109 18 ( ( -LRB- 10_1101-2021_01_06_425584 109 19 32 32 CD 10_1101-2021_01_06_425584 109 20 ) ) -RRB- 10_1101-2021_01_06_425584 109 21 . . . 10_1101-2021_01_06_425584 110 1 The the DT 10_1101-2021_01_06_425584 110 2 NormalyzerDE NormalyzerDE NNP 10_1101-2021_01_06_425584 110 3 pipeline pipeline NN 10_1101-2021_01_06_425584 110 4 207 207 CD 10_1101-2021_01_06_425584 110 5 comprises comprise NNS 10_1101-2021_01_06_425584 110 6 8 8 CD 10_1101-2021_01_06_425584 110 7 different different JJ 10_1101-2021_01_06_425584 110 8 normalization normalization NN 10_1101-2021_01_06_425584 110 9 methods method NNS 10_1101-2021_01_06_425584 110 10 ( ( -LRB- 10_1101-2021_01_06_425584 110 11 Log2 log2 UH 10_1101-2021_01_06_425584 110 12 , , , 10_1101-2021_01_06_425584 110 13 variance variance NN 10_1101-2021_01_06_425584 110 14 stabilizing stabilize VBG 10_1101-2021_01_06_425584 110 15 normalization normalization NN 10_1101-2021_01_06_425584 110 16 , , , 10_1101-2021_01_06_425584 110 17 total total JJ 10_1101-2021_01_06_425584 110 18 208 208 CD 10_1101-2021_01_06_425584 110 19 intensity intensity NN 10_1101-2021_01_06_425584 110 20 , , , 10_1101-2021_01_06_425584 110 21 median median NNP 10_1101-2021_01_06_425584 110 22 , , , 10_1101-2021_01_06_425584 110 23 mean mean JJ 10_1101-2021_01_06_425584 110 24 , , , 10_1101-2021_01_06_425584 110 25 quantile quantile NNP 10_1101-2021_01_06_425584 110 26 , , , 10_1101-2021_01_06_425584 110 27 CycLoess CycLoess NNP 10_1101-2021_01_06_425584 110 28 , , , 10_1101-2021_01_06_425584 110 29 and and CC 10_1101-2021_01_06_425584 110 30 robust robust JJ 10_1101-2021_01_06_425584 110 31 linear linear JJ 10_1101-2021_01_06_425584 110 32 regression regression NN 10_1101-2021_01_06_425584 110 33 ) ) -RRB- 10_1101-2021_01_06_425584 110 34 . . . 10_1101-2021_01_06_425584 111 1 The the DT 10_1101-2021_01_06_425584 111 2 results result NNS 10_1101-2021_01_06_425584 111 3 of of IN 10_1101-2021_01_06_425584 111 4 209 209 CD 10_1101-2021_01_06_425584 111 5 qualitative qualitative JJ 10_1101-2021_01_06_425584 111 6 ( ( -LRB- 10_1101-2021_01_06_425584 111 7 MA MA NNP 10_1101-2021_01_06_425584 111 8 plots plot NNS 10_1101-2021_01_06_425584 111 9 , , , 10_1101-2021_01_06_425584 111 10 scatter scatter NN 10_1101-2021_01_06_425584 111 11 plots plot NNS 10_1101-2021_01_06_425584 111 12 , , , 10_1101-2021_01_06_425584 111 13 box box NN 10_1101-2021_01_06_425584 111 14 plots plot NNS 10_1101-2021_01_06_425584 111 15 , , , 10_1101-2021_01_06_425584 111 16 density density NN 10_1101-2021_01_06_425584 111 17 plots plot NNS 10_1101-2021_01_06_425584 111 18 ) ) -RRB- 10_1101-2021_01_06_425584 111 19 and and CC 10_1101-2021_01_06_425584 111 20 quantitative quantitative JJ 10_1101-2021_01_06_425584 111 21 ( ( -LRB- 10_1101-2021_01_06_425584 111 22 pooled pool VBN 10_1101-2021_01_06_425584 111 23 intragroup intragroup NNP 10_1101-2021_01_06_425584 111 24 210 210 CD 10_1101-2021_01_06_425584 111 25 coefficient coefficient NN 10_1101-2021_01_06_425584 111 26 of of IN 10_1101-2021_01_06_425584 111 27 variation variation NN 10_1101-2021_01_06_425584 111 28 [ [ -LRB- 10_1101-2021_01_06_425584 111 29 PCV PCV NNP 10_1101-2021_01_06_425584 111 30 ] ] -RRB- 10_1101-2021_01_06_425584 111 31 , , , 10_1101-2021_01_06_425584 111 32 median median JJ 10_1101-2021_01_06_425584 111 33 absolute absolute JJ 10_1101-2021_01_06_425584 111 34 deviation deviation NN 10_1101-2021_01_06_425584 111 35 [ [ -LRB- 10_1101-2021_01_06_425584 111 36 PMAD PMAD NNP 10_1101-2021_01_06_425584 111 37 ] ] -RRB- 10_1101-2021_01_06_425584 111 38 , , , 10_1101-2021_01_06_425584 111 39 estimate estimate NN 10_1101-2021_01_06_425584 111 40 of of IN 10_1101-2021_01_06_425584 111 41 variance variance NN 10_1101-2021_01_06_425584 111 42 [ [ -LRB- 10_1101-2021_01_06_425584 111 43 PEV PEV NNP 10_1101-2021_01_06_425584 111 44 ] ] -RRB- 10_1101-2021_01_06_425584 111 45 ) ) -RRB- 10_1101-2021_01_06_425584 111 46 211 211 CD 10_1101-2021_01_06_425584 111 47 parameters parameter NNS 10_1101-2021_01_06_425584 111 48 were be VBD 10_1101-2021_01_06_425584 111 49 compared compare VBN 10_1101-2021_01_06_425584 111 50 between between IN 10_1101-2021_01_06_425584 111 51 the the DT 10_1101-2021_01_06_425584 111 52 normalization normalization NN 10_1101-2021_01_06_425584 111 53 methods method NNS 10_1101-2021_01_06_425584 111 54 to to TO 10_1101-2021_01_06_425584 111 55 select select VB 10_1101-2021_01_06_425584 111 56 the the DT 10_1101-2021_01_06_425584 111 57 most most RBS 10_1101-2021_01_06_425584 111 58 appropriate appropriate JJ 10_1101-2021_01_06_425584 111 59 . . . 10_1101-2021_01_06_425584 112 1 212 212 CD 10_1101-2021_01_06_425584 112 2 213 213 CD 10_1101-2021_01_06_425584 112 3 2.9 2.9 CD 10_1101-2021_01_06_425584 112 4 Bioinformatic bioinformatic JJ 10_1101-2021_01_06_425584 112 5 analysis analysis NN 10_1101-2021_01_06_425584 112 6 of of IN 10_1101-2021_01_06_425584 112 7 proteomics proteomic NNS 10_1101-2021_01_06_425584 112 8 data datum NNS 10_1101-2021_01_06_425584 112 9 214 214 CD 10_1101-2021_01_06_425584 112 10 Proteins Proteins NNPS 10_1101-2021_01_06_425584 112 11 that that WDT 10_1101-2021_01_06_425584 112 12 passed pass VBD 10_1101-2021_01_06_425584 112 13 the the DT 10_1101-2021_01_06_425584 112 14 significance significance NN 10_1101-2021_01_06_425584 112 15 threshold threshold NN 10_1101-2021_01_06_425584 112 16 were be VBD 10_1101-2021_01_06_425584 112 17 first first RB 10_1101-2021_01_06_425584 112 18 converted convert VBN 10_1101-2021_01_06_425584 112 19 to to IN 10_1101-2021_01_06_425584 112 20 their -PRON- PRP$ 10_1101-2021_01_06_425584 112 21 corresponding correspond VBG 10_1101-2021_01_06_425584 112 22 Entrez Entrez NNP 10_1101-2021_01_06_425584 112 23 215 215 CD 10_1101-2021_01_06_425584 112 24 Gene Gene NNP 10_1101-2021_01_06_425584 112 25 ( ( -LRB- 10_1101-2021_01_06_425584 112 26 GeneID GeneID NNP 10_1101-2021_01_06_425584 112 27 ) ) -RRB- 10_1101-2021_01_06_425584 112 28 using use VBG 10_1101-2021_01_06_425584 112 29 https://www.uniprot.org/uploadlists/ https://www.uniprot.org/uploadlists/ NNP 10_1101-2021_01_06_425584 112 30 and and CC 10_1101-2021_01_06_425584 112 31 then then RB 10_1101-2021_01_06_425584 112 32 transformed transform VBD 10_1101-2021_01_06_425584 112 33 to to IN 10_1101-2021_01_06_425584 112 34 their -PRON- PRP$ 10_1101-2021_01_06_425584 112 35 human human JJ 10_1101-2021_01_06_425584 112 36 216 216 CD 10_1101-2021_01_06_425584 112 37 equivalents equivalent NNS 10_1101-2021_01_06_425584 112 38 using use VBG 10_1101-2021_01_06_425584 112 39 the the DT 10_1101-2021_01_06_425584 112 40 ortholog ortholog NNP 10_1101-2021_01_06_425584 112 41 conversion conversion NN 10_1101-2021_01_06_425584 112 42 feature feature NN 10_1101-2021_01_06_425584 112 43 in in IN 10_1101-2021_01_06_425584 112 44 https://biodbnet-217 https://biodbnet-217 NNP 10_1101-2021_01_06_425584 112 45 abcc.ncifcrf.gov/db/dbOrtho.php abcc.ncifcrf.gov/db/dbortho.php ADD 10_1101-2021_01_06_425584 112 46 . . . 10_1101-2021_01_06_425584 113 1 Bioinformatic bioinformatic JJ 10_1101-2021_01_06_425584 113 2 analysis analysis NN 10_1101-2021_01_06_425584 113 3 was be VBD 10_1101-2021_01_06_425584 113 4 done do VBN 10_1101-2021_01_06_425584 113 5 on on IN 10_1101-2021_01_06_425584 113 6 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 113 7 website website NN 10_1101-2021_01_06_425584 113 8 platform platform NN 10_1101-2021_01_06_425584 113 9 218 218 CD 10_1101-2021_01_06_425584 113 10 .CC .CC : 10_1101-2021_01_06_425584 113 11 - - HYPH 10_1101-2021_01_06_425584 113 12 BY by IN 10_1101-2021_01_06_425584 113 13 - - HYPH 10_1101-2021_01_06_425584 113 14 NC NC NNP 10_1101-2021_01_06_425584 113 15 - - HYPH 10_1101-2021_01_06_425584 113 16 ND ND NNP 10_1101-2021_01_06_425584 113 17 4.0 4.0 CD 10_1101-2021_01_06_425584 113 18 International International NNP 10_1101-2021_01_06_425584 113 19 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 113 20 under under IN 10_1101-2021_01_06_425584 113 21 a a DT 10_1101-2021_01_06_425584 113 22 ( ( -LRB- 10_1101-2021_01_06_425584 113 23 which which WDT 10_1101-2021_01_06_425584 113 24 was be VBD 10_1101-2021_01_06_425584 113 25 not not RB 10_1101-2021_01_06_425584 113 26 certified certify VBN 10_1101-2021_01_06_425584 113 27 by by IN 10_1101-2021_01_06_425584 113 28 peer peer NN 10_1101-2021_01_06_425584 113 29 review review NN 10_1101-2021_01_06_425584 113 30 ) ) -RRB- 10_1101-2021_01_06_425584 113 31 is be VBZ 10_1101-2021_01_06_425584 113 32 the the DT 10_1101-2021_01_06_425584 113 33 author author NN 10_1101-2021_01_06_425584 113 34 / / SYM 10_1101-2021_01_06_425584 113 35 funder funder NN 10_1101-2021_01_06_425584 113 36 , , , 10_1101-2021_01_06_425584 113 37 who who WP 10_1101-2021_01_06_425584 113 38 has have VBZ 10_1101-2021_01_06_425584 113 39 granted grant VBN 10_1101-2021_01_06_425584 113 40 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 113 41 a a DT 10_1101-2021_01_06_425584 113 42 license license NN 10_1101-2021_01_06_425584 113 43 to to TO 10_1101-2021_01_06_425584 113 44 display display VB 10_1101-2021_01_06_425584 113 45 the the DT 10_1101-2021_01_06_425584 113 46 preprint preprint NN 10_1101-2021_01_06_425584 113 47 in in IN 10_1101-2021_01_06_425584 113 48 perpetuity perpetuity NN 10_1101-2021_01_06_425584 113 49 . . . 10_1101-2021_01_06_425584 114 1 It -PRON- PRP 10_1101-2021_01_06_425584 114 2 is be VBZ 10_1101-2021_01_06_425584 114 3 made make VBN 10_1101-2021_01_06_425584 114 4 The the DT 10_1101-2021_01_06_425584 114 5 copyright copyright NN 10_1101-2021_01_06_425584 114 6 holder holder NN 10_1101-2021_01_06_425584 114 7 for for IN 10_1101-2021_01_06_425584 114 8 this this DT 10_1101-2021_01_06_425584 114 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 114 10 version version NN 10_1101-2021_01_06_425584 114 11 posted post VBD 10_1101-2021_01_06_425584 114 12 January January NNP 10_1101-2021_01_06_425584 114 13 8 8 CD 10_1101-2021_01_06_425584 114 14 , , , 10_1101-2021_01_06_425584 114 15 2021 2021 CD 10_1101-2021_01_06_425584 114 16 . . . 10_1101-2021_01_06_425584 114 17 ; ; : 10_1101-2021_01_06_425584 114 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 114 19 : : : 10_1101-2021_01_06_425584 114 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 114 21 preprint preprint NN 10_1101-2021_01_06_425584 114 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 114 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 114 24 8 8 CD 10_1101-2021_01_06_425584 114 25 ( ( -LRB- 10_1101-2021_01_06_425584 114 26 https://www.omicsnet.ca/ https://www.omicsnet.ca/ NN 10_1101-2021_01_06_425584 114 27 ) ) -RRB- 10_1101-2021_01_06_425584 114 28 ( ( -LRB- 10_1101-2021_01_06_425584 114 29 33 33 CD 10_1101-2021_01_06_425584 114 30 , , , 10_1101-2021_01_06_425584 114 31 34 34 CD 10_1101-2021_01_06_425584 114 32 ) ) -RRB- 10_1101-2021_01_06_425584 114 33 . . . 10_1101-2021_01_06_425584 115 1 First first RB 10_1101-2021_01_06_425584 115 2 , , , 10_1101-2021_01_06_425584 115 3 a a DT 10_1101-2021_01_06_425584 115 4 protein protein NN 10_1101-2021_01_06_425584 115 5 - - HYPH 10_1101-2021_01_06_425584 115 6 protein protein NN 10_1101-2021_01_06_425584 115 7 interaction interaction NN 10_1101-2021_01_06_425584 115 8 ( ( -LRB- 10_1101-2021_01_06_425584 115 9 PPI PPI NNP 10_1101-2021_01_06_425584 115 10 ) ) -RRB- 10_1101-2021_01_06_425584 115 11 molecular molecular JJ 10_1101-2021_01_06_425584 115 12 network network NN 10_1101-2021_01_06_425584 115 13 219 219 CD 10_1101-2021_01_06_425584 115 14 ( ( -LRB- 10_1101-2021_01_06_425584 115 15 first first JJ 10_1101-2021_01_06_425584 115 16 - - HYPH 10_1101-2021_01_06_425584 115 17 order order NN 10_1101-2021_01_06_425584 115 18 network network NN 10_1101-2021_01_06_425584 115 19 containing contain VBG 10_1101-2021_01_06_425584 115 20 query query NN 10_1101-2021_01_06_425584 115 21 or or CC 10_1101-2021_01_06_425584 115 22 seeds seed VBZ 10_1101-2021_01_06_425584 115 23 molecules molecule NNS 10_1101-2021_01_06_425584 115 24 and and CC 10_1101-2021_01_06_425584 115 25 their -PRON- PRP$ 10_1101-2021_01_06_425584 115 26 immediate immediate JJ 10_1101-2021_01_06_425584 115 27 interacting interact VBG 10_1101-2021_01_06_425584 115 28 partners partner NNS 10_1101-2021_01_06_425584 115 29 ) ) -RRB- 10_1101-2021_01_06_425584 115 30 220 220 CD 10_1101-2021_01_06_425584 115 31 using use VBG 10_1101-2021_01_06_425584 115 32 STRING STRING NNP 10_1101-2021_01_06_425584 115 33 PPI PPI NNP 10_1101-2021_01_06_425584 115 34 database database NN 10_1101-2021_01_06_425584 115 35 was be VBD 10_1101-2021_01_06_425584 115 36 built build VBN 10_1101-2021_01_06_425584 115 37 ( ( -LRB- 10_1101-2021_01_06_425584 115 38 35 35 CD 10_1101-2021_01_06_425584 115 39 ) ) -RRB- 10_1101-2021_01_06_425584 115 40 and and CC 10_1101-2021_01_06_425584 115 41 then then RB 10_1101-2021_01_06_425584 115 42 pathway pathway NNP 10_1101-2021_01_06_425584 115 43 enrichment enrichment NN 10_1101-2021_01_06_425584 115 44 analysis analysis NN 10_1101-2021_01_06_425584 115 45 was be VBD 10_1101-2021_01_06_425584 115 46 performed perform VBN 10_1101-2021_01_06_425584 115 47 221 221 CD 10_1101-2021_01_06_425584 115 48 using use VBG 10_1101-2021_01_06_425584 115 49 the the DT 10_1101-2021_01_06_425584 115 50 built build VBN 10_1101-2021_01_06_425584 115 51 - - HYPH 10_1101-2021_01_06_425584 115 52 in in RP 10_1101-2021_01_06_425584 115 53 REACTOME reactome NN 10_1101-2021_01_06_425584 115 54 and and CC 10_1101-2021_01_06_425584 115 55 the the DT 10_1101-2021_01_06_425584 115 56 Kyoto Kyoto NNP 10_1101-2021_01_06_425584 115 57 Encyclopedia Encyclopedia NNP 10_1101-2021_01_06_425584 115 58 of of IN 10_1101-2021_01_06_425584 115 59 Genes Genes NNPS 10_1101-2021_01_06_425584 115 60 and and CC 10_1101-2021_01_06_425584 115 61 Genomes Genomes NNP 10_1101-2021_01_06_425584 115 62 ( ( -LRB- 10_1101-2021_01_06_425584 115 63 KEGG KEGG NNP 10_1101-2021_01_06_425584 115 64 ) ) -RRB- 10_1101-2021_01_06_425584 115 65 222 222 CD 10_1101-2021_01_06_425584 115 66 databases database NNS 10_1101-2021_01_06_425584 115 67 . . . 10_1101-2021_01_06_425584 116 1 To to TO 10_1101-2021_01_06_425584 116 2 visualize visualize VB 10_1101-2021_01_06_425584 116 3 modules module NNS 10_1101-2021_01_06_425584 116 4 ( ( -LRB- 10_1101-2021_01_06_425584 116 5 functional functional JJ 10_1101-2021_01_06_425584 116 6 units unit NNS 10_1101-2021_01_06_425584 116 7 ) ) -RRB- 10_1101-2021_01_06_425584 116 8 contained contain VBN 10_1101-2021_01_06_425584 116 9 in in IN 10_1101-2021_01_06_425584 116 10 the the DT 10_1101-2021_01_06_425584 116 11 molecular molecular JJ 10_1101-2021_01_06_425584 116 12 network network NN 10_1101-2021_01_06_425584 116 13 the the DT 10_1101-2021_01_06_425584 116 14 223 223 CD 10_1101-2021_01_06_425584 116 15 WalkTrap WalkTrap NNP 10_1101-2021_01_06_425584 116 16 algorithm algorithm NN 10_1101-2021_01_06_425584 116 17 ( ( -LRB- 10_1101-2021_01_06_425584 116 18 within within IN 10_1101-2021_01_06_425584 116 19 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 116 20 platform platform NN 10_1101-2021_01_06_425584 116 21 ) ) -RRB- 10_1101-2021_01_06_425584 116 22 was be VBD 10_1101-2021_01_06_425584 116 23 employed employ VBN 10_1101-2021_01_06_425584 116 24 . . . 10_1101-2021_01_06_425584 117 1 Hypergeometric hypergeometric JJ 10_1101-2021_01_06_425584 117 2 test test NN 10_1101-2021_01_06_425584 117 3 was be VBD 10_1101-2021_01_06_425584 117 4 used use VBN 10_1101-2021_01_06_425584 117 5 to to IN 10_1101-2021_01_06_425584 117 6 224 224 CD 10_1101-2021_01_06_425584 117 7 compute compute JJ 10_1101-2021_01_06_425584 117 8 p p NN 10_1101-2021_01_06_425584 117 9 - - HYPH 10_1101-2021_01_06_425584 117 10 values value NNS 10_1101-2021_01_06_425584 117 11 . . . 10_1101-2021_01_06_425584 118 1 225 225 CD 10_1101-2021_01_06_425584 118 2 226 226 CD 10_1101-2021_01_06_425584 118 3 2.10 2.10 CD 10_1101-2021_01_06_425584 118 4 Integrative integrative JJ 10_1101-2021_01_06_425584 118 5 analysis analysis NN 10_1101-2021_01_06_425584 118 6 of of IN 10_1101-2021_01_06_425584 118 7 proteomics proteomic NNS 10_1101-2021_01_06_425584 118 8 and and CC 10_1101-2021_01_06_425584 118 9 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 118 10 data datum NNS 10_1101-2021_01_06_425584 118 11 227 227 CD 10_1101-2021_01_06_425584 118 12 The the DT 10_1101-2021_01_06_425584 118 13 molecular molecular JJ 10_1101-2021_01_06_425584 118 14 interactions interaction NNS 10_1101-2021_01_06_425584 118 15 between between IN 10_1101-2021_01_06_425584 118 16 the the DT 10_1101-2021_01_06_425584 118 17 proteins protein NNS 10_1101-2021_01_06_425584 118 18 and and CC 10_1101-2021_01_06_425584 118 19 metabolites metabolite NNS 10_1101-2021_01_06_425584 118 20 differentially differentially RB 10_1101-2021_01_06_425584 118 21 abundant abundant JJ 10_1101-2021_01_06_425584 118 22 between between IN 10_1101-2021_01_06_425584 118 23 228 228 CD 10_1101-2021_01_06_425584 118 24 HG HG NNP 10_1101-2021_01_06_425584 118 25 + + CC 10_1101-2021_01_06_425584 118 26 HI HI NNP 10_1101-2021_01_06_425584 118 27 and and CC 10_1101-2021_01_06_425584 118 28 NG NG NNP 10_1101-2021_01_06_425584 118 29 were be VBD 10_1101-2021_01_06_425584 118 30 determined determine VBN 10_1101-2021_01_06_425584 118 31 in in IN 10_1101-2021_01_06_425584 118 32 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 118 33 ( ( -LRB- 10_1101-2021_01_06_425584 118 34 32 32 CD 10_1101-2021_01_06_425584 118 35 , , , 10_1101-2021_01_06_425584 118 36 33 33 CD 10_1101-2021_01_06_425584 118 37 ) ) -RRB- 10_1101-2021_01_06_425584 118 38 . . . 10_1101-2021_01_06_425584 119 1 The the DT 10_1101-2021_01_06_425584 119 2 lists list NNS 10_1101-2021_01_06_425584 119 3 of of IN 10_1101-2021_01_06_425584 119 4 proteins protein NNS 10_1101-2021_01_06_425584 119 5 ( ( -LRB- 10_1101-2021_01_06_425584 119 6 EntrezGene EntrezGene NNP 10_1101-2021_01_06_425584 119 7 ID ID NNP 10_1101-2021_01_06_425584 119 8 ) ) -RRB- 10_1101-2021_01_06_425584 119 9 229 229 CD 10_1101-2021_01_06_425584 119 10 and and CC 10_1101-2021_01_06_425584 119 11 metabolites metabolite NNS 10_1101-2021_01_06_425584 119 12 ( ( -LRB- 10_1101-2021_01_06_425584 119 13 HMDB HMDB NNP 10_1101-2021_01_06_425584 119 14 ID ID NNP 10_1101-2021_01_06_425584 119 15 ) ) -RRB- 10_1101-2021_01_06_425584 119 16 were be VBD 10_1101-2021_01_06_425584 119 17 loaded load VBN 10_1101-2021_01_06_425584 119 18 to to TO 10_1101-2021_01_06_425584 119 19 build build VB 10_1101-2021_01_06_425584 119 20 a a DT 10_1101-2021_01_06_425584 119 21 composite composite JJ 10_1101-2021_01_06_425584 119 22 network network NN 10_1101-2021_01_06_425584 119 23 using use VBG 10_1101-2021_01_06_425584 119 24 protein protein NN 10_1101-2021_01_06_425584 119 25 - - HYPH 10_1101-2021_01_06_425584 119 26 protein protein NN 10_1101-2021_01_06_425584 119 27 230 230 CD 10_1101-2021_01_06_425584 119 28 ( ( -LRB- 10_1101-2021_01_06_425584 119 29 STRING string NN 10_1101-2021_01_06_425584 119 30 database database NN 10_1101-2021_01_06_425584 119 31 selected select VBN 10_1101-2021_01_06_425584 119 32 ) ) -RRB- 10_1101-2021_01_06_425584 119 33 and and CC 10_1101-2021_01_06_425584 119 34 metabolite metabolite JJ 10_1101-2021_01_06_425584 119 35 - - HYPH 10_1101-2021_01_06_425584 119 36 protein protein NN 10_1101-2021_01_06_425584 119 37 ( ( -LRB- 10_1101-2021_01_06_425584 119 38 KEGG KEGG NNP 10_1101-2021_01_06_425584 119 39 database database NN 10_1101-2021_01_06_425584 119 40 selected select VBN 10_1101-2021_01_06_425584 119 41 ) ) -RRB- 10_1101-2021_01_06_425584 119 42 interaction interaction NN 10_1101-2021_01_06_425584 119 43 types type NNS 10_1101-2021_01_06_425584 119 44 . . . 10_1101-2021_01_06_425584 120 1 231 231 CD 10_1101-2021_01_06_425584 120 2 The the DT 10_1101-2021_01_06_425584 120 3 primary primary JJ 10_1101-2021_01_06_425584 120 4 network network NN 10_1101-2021_01_06_425584 120 5 relied rely VBN 10_1101-2021_01_06_425584 120 6 on on IN 10_1101-2021_01_06_425584 120 7 the the DT 10_1101-2021_01_06_425584 120 8 metabolite metabolite JJ 10_1101-2021_01_06_425584 120 9 input input NN 10_1101-2021_01_06_425584 120 10 . . . 10_1101-2021_01_06_425584 121 1 Pathway pathway JJ 10_1101-2021_01_06_425584 121 2 enrichment enrichment NN 10_1101-2021_01_06_425584 121 3 analysis analysis NN 10_1101-2021_01_06_425584 121 4 was be VBD 10_1101-2021_01_06_425584 121 5 performed perform VBN 10_1101-2021_01_06_425584 121 6 232 232 CD 10_1101-2021_01_06_425584 121 7 using use VBG 10_1101-2021_01_06_425584 121 8 the the DT 10_1101-2021_01_06_425584 121 9 built build VBN 10_1101-2021_01_06_425584 121 10 - - HYPH 10_1101-2021_01_06_425584 121 11 in in RP 10_1101-2021_01_06_425584 121 12 REACTOME reactome NN 10_1101-2021_01_06_425584 121 13 and and CC 10_1101-2021_01_06_425584 121 14 KEGG KEGG NNP 10_1101-2021_01_06_425584 121 15 databases database VBZ 10_1101-2021_01_06_425584 121 16 . . . 10_1101-2021_01_06_425584 122 1 Hypergeometric hypergeometric JJ 10_1101-2021_01_06_425584 122 2 test test NN 10_1101-2021_01_06_425584 122 3 was be VBD 10_1101-2021_01_06_425584 122 4 used use VBN 10_1101-2021_01_06_425584 122 5 to to TO 10_1101-2021_01_06_425584 122 6 compute compute VB 10_1101-2021_01_06_425584 122 7 233 233 CD 10_1101-2021_01_06_425584 122 8 p p NN 10_1101-2021_01_06_425584 122 9 - - HYPH 10_1101-2021_01_06_425584 122 10 values value NNS 10_1101-2021_01_06_425584 122 11 . . . 10_1101-2021_01_06_425584 123 1 234 234 CD 10_1101-2021_01_06_425584 123 2 235 235 CD 10_1101-2021_01_06_425584 123 3 2.11 2.11 CD 10_1101-2021_01_06_425584 123 4 Statistical statistical JJ 10_1101-2021_01_06_425584 123 5 analysis analysis NN 10_1101-2021_01_06_425584 123 6 236 236 CD 10_1101-2021_01_06_425584 123 7 All all DT 10_1101-2021_01_06_425584 123 8 experiments experiment NNS 10_1101-2021_01_06_425584 123 9 were be VBD 10_1101-2021_01_06_425584 123 10 performed perform VBN 10_1101-2021_01_06_425584 123 11 in in IN 10_1101-2021_01_06_425584 123 12 triplicate triplicate NN 10_1101-2021_01_06_425584 123 13 . . . 10_1101-2021_01_06_425584 124 1 Based base VBN 10_1101-2021_01_06_425584 124 2 on on IN 10_1101-2021_01_06_425584 124 3 the the DT 10_1101-2021_01_06_425584 124 4 accuracy accuracy NN 10_1101-2021_01_06_425584 124 5 ( ( -LRB- 10_1101-2021_01_06_425584 124 6 determination determination NN 10_1101-2021_01_06_425584 124 7 of of IN 10_1101-2021_01_06_425584 124 8 real real JJ 10_1101-2021_01_06_425584 124 9 fold-237 fold-237 NN 10_1101-2021_01_06_425584 124 10 changes change NNS 10_1101-2021_01_06_425584 124 11 ) ) -RRB- 10_1101-2021_01_06_425584 124 12 of of IN 10_1101-2021_01_06_425584 124 13 SWATH SWATH NNP 10_1101-2021_01_06_425584 124 14 - - HYPH 10_1101-2021_01_06_425584 124 15 based base VBN 10_1101-2021_01_06_425584 124 16 quantification quantification NN 10_1101-2021_01_06_425584 124 17 ( ( -LRB- 10_1101-2021_01_06_425584 124 18 36 36 CD 10_1101-2021_01_06_425584 124 19 ) ) -RRB- 10_1101-2021_01_06_425584 124 20 , , , 10_1101-2021_01_06_425584 124 21 proteins protein VBZ 10_1101-2021_01_06_425584 124 22 with with IN 10_1101-2021_01_06_425584 124 23 a a DT 10_1101-2021_01_06_425584 124 24 fold fold JJ 10_1101-2021_01_06_425584 124 25 change change NN 10_1101-2021_01_06_425584 124 26 ≥ ≥ UH 10_1101-2021_01_06_425584 124 27 1.2 1.2 CD 10_1101-2021_01_06_425584 124 28 or or CC 10_1101-2021_01_06_425584 124 29 ≤ ≤ JJ 10_1101-2021_01_06_425584 124 30 1/1.2 1/1.2 NNS 10_1101-2021_01_06_425584 124 31 and and CC 10_1101-2021_01_06_425584 124 32 a a DT 10_1101-2021_01_06_425584 124 33 238 238 CD 10_1101-2021_01_06_425584 124 34 p p NN 10_1101-2021_01_06_425584 124 35 - - HYPH 10_1101-2021_01_06_425584 124 36 value value NN 10_1101-2021_01_06_425584 124 37 < < XX 10_1101-2021_01_06_425584 124 38 0.05 0.05 CD 10_1101-2021_01_06_425584 124 39 ( ( -LRB- 10_1101-2021_01_06_425584 124 40 Welch Welch NNP 10_1101-2021_01_06_425584 124 41 ’s ’s POS 10_1101-2021_01_06_425584 124 42 t t NN 10_1101-2021_01_06_425584 124 43 - - HYPH 10_1101-2021_01_06_425584 124 44 test test NN 10_1101-2021_01_06_425584 124 45 ) ) -RRB- 10_1101-2021_01_06_425584 124 46 were be VBD 10_1101-2021_01_06_425584 124 47 considered consider VBN 10_1101-2021_01_06_425584 124 48 as as RB 10_1101-2021_01_06_425584 124 49 differentially differentially RB 10_1101-2021_01_06_425584 124 50 abundant abundant JJ 10_1101-2021_01_06_425584 124 51 between between IN 10_1101-2021_01_06_425584 124 52 NG NG NNP 10_1101-2021_01_06_425584 124 53 and and CC 10_1101-2021_01_06_425584 124 54 HG HG NNP 10_1101-2021_01_06_425584 124 55 + + CC 10_1101-2021_01_06_425584 124 56 239 239 CD 10_1101-2021_01_06_425584 124 57 HI HI NNP 10_1101-2021_01_06_425584 124 58 conditions condition NNS 10_1101-2021_01_06_425584 124 59 . . . 10_1101-2021_01_06_425584 125 1 For for IN 10_1101-2021_01_06_425584 125 2 the the DT 10_1101-2021_01_06_425584 125 3 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 125 4 data datum NNS 10_1101-2021_01_06_425584 125 5 , , , 10_1101-2021_01_06_425584 125 6 features feature VBZ 10_1101-2021_01_06_425584 125 7 with with IN 10_1101-2021_01_06_425584 125 8 a a DT 10_1101-2021_01_06_425584 125 9 fold fold JJ 10_1101-2021_01_06_425584 125 10 change change NN 10_1101-2021_01_06_425584 125 11 ≥ ≥ NNP 10_1101-2021_01_06_425584 125 12 1.3 1.3 CD 10_1101-2021_01_06_425584 125 13 or or CC 10_1101-2021_01_06_425584 125 14 ≤ ≤ JJ 10_1101-2021_01_06_425584 125 15 1/1.3 1/1.3 NNS 10_1101-2021_01_06_425584 125 16 and and CC 10_1101-2021_01_06_425584 125 17 a a DT 10_1101-2021_01_06_425584 125 18 p-240 p-240 NNP 10_1101-2021_01_06_425584 125 19 value value NN 10_1101-2021_01_06_425584 125 20 < < XX 10_1101-2021_01_06_425584 125 21 0.05 0.05 CD 10_1101-2021_01_06_425584 125 22 ( ( -LRB- 10_1101-2021_01_06_425584 125 23 Welch Welch NNP 10_1101-2021_01_06_425584 125 24 ’s ’s POS 10_1101-2021_01_06_425584 125 25 t t NN 10_1101-2021_01_06_425584 125 26 - - HYPH 10_1101-2021_01_06_425584 125 27 test test NN 10_1101-2021_01_06_425584 125 28 ) ) -RRB- 10_1101-2021_01_06_425584 125 29 were be VBD 10_1101-2021_01_06_425584 125 30 considered consider VBN 10_1101-2021_01_06_425584 125 31 as as RB 10_1101-2021_01_06_425584 125 32 differentially differentially RB 10_1101-2021_01_06_425584 125 33 abundant abundant JJ 10_1101-2021_01_06_425584 125 34 . . . 10_1101-2021_01_06_425584 126 1 We -PRON- PRP 10_1101-2021_01_06_425584 126 2 did do VBD 10_1101-2021_01_06_425584 126 3 not not RB 10_1101-2021_01_06_425584 126 4 apply apply VB 10_1101-2021_01_06_425584 126 5 multiple-241 multiple-241 NNP 10_1101-2021_01_06_425584 126 6 test test NN 10_1101-2021_01_06_425584 126 7 corrections correction NNS 10_1101-2021_01_06_425584 126 8 to to TO 10_1101-2021_01_06_425584 126 9 calculate calculate VB 10_1101-2021_01_06_425584 126 10 adjusted adjusted JJ 10_1101-2021_01_06_425584 126 11 p p NN 10_1101-2021_01_06_425584 126 12 - - HYPH 10_1101-2021_01_06_425584 126 13 values value NNS 10_1101-2021_01_06_425584 126 14 , , , 10_1101-2021_01_06_425584 126 15 because because IN 10_1101-2021_01_06_425584 126 16 this this DT 10_1101-2021_01_06_425584 126 17 process process NN 10_1101-2021_01_06_425584 126 18 could could MD 10_1101-2021_01_06_425584 126 19 obscure obscure VB 10_1101-2021_01_06_425584 126 20 proteins protein NNS 10_1101-2021_01_06_425584 126 21 or or CC 10_1101-2021_01_06_425584 126 22 242 242 CD 10_1101-2021_01_06_425584 126 23 metabolites metabolite NNS 10_1101-2021_01_06_425584 126 24 with with IN 10_1101-2021_01_06_425584 126 25 real real JJ 10_1101-2021_01_06_425584 126 26 changes change NNS 10_1101-2021_01_06_425584 126 27 ( ( -LRB- 10_1101-2021_01_06_425584 126 28 true true JJ 10_1101-2021_01_06_425584 126 29 - - HYPH 10_1101-2021_01_06_425584 126 30 positives positive NNS 10_1101-2021_01_06_425584 126 31 ) ) -RRB- 10_1101-2021_01_06_425584 126 32 ( ( -LRB- 10_1101-2021_01_06_425584 126 33 37 37 CD 10_1101-2021_01_06_425584 126 34 ) ) -RRB- 10_1101-2021_01_06_425584 126 35 . . . 10_1101-2021_01_06_425584 127 1 Instead instead RB 10_1101-2021_01_06_425584 127 2 , , , 10_1101-2021_01_06_425584 127 3 the the DT 10_1101-2021_01_06_425584 127 4 analysis analysis NN 10_1101-2021_01_06_425584 127 5 was be VBD 10_1101-2021_01_06_425584 127 6 focused focus VBN 10_1101-2021_01_06_425584 127 7 on on IN 10_1101-2021_01_06_425584 127 8 top-243 top-243 NNP 10_1101-2021_01_06_425584 127 9 enriched enrich VBD 10_1101-2021_01_06_425584 127 10 signaling signal VBG 10_1101-2021_01_06_425584 127 11 pathways pathway NNS 10_1101-2021_01_06_425584 127 12 ( ( -LRB- 10_1101-2021_01_06_425584 127 13 adjusted adjust VBN 10_1101-2021_01_06_425584 127 14 p p NN 10_1101-2021_01_06_425584 127 15 - - HYPH 10_1101-2021_01_06_425584 127 16 value value NN 10_1101-2021_01_06_425584 127 17 < < XX 10_1101-2021_01_06_425584 127 18 0.01 0.01 XX 10_1101-2021_01_06_425584 127 19 ) ) -RRB- 10_1101-2021_01_06_425584 127 20 that that WDT 10_1101-2021_01_06_425584 127 21 allowed allow VBD 10_1101-2021_01_06_425584 127 22 us -PRON- PRP 10_1101-2021_01_06_425584 127 23 to to TO 10_1101-2021_01_06_425584 127 24 determine determine VB 10_1101-2021_01_06_425584 127 25 a a DT 10_1101-2021_01_06_425584 127 26 set set NN 10_1101-2021_01_06_425584 127 27 of of IN 10_1101-2021_01_06_425584 127 28 244 244 CD 10_1101-2021_01_06_425584 127 29 interacting interact VBG 10_1101-2021_01_06_425584 127 30 proteins protein NNS 10_1101-2021_01_06_425584 127 31 and and CC 10_1101-2021_01_06_425584 127 32 metabolites metabolite NNS 10_1101-2021_01_06_425584 127 33 with with IN 10_1101-2021_01_06_425584 127 34 relevant relevant JJ 10_1101-2021_01_06_425584 127 35 biological biological JJ 10_1101-2021_01_06_425584 127 36 information information NN 10_1101-2021_01_06_425584 127 37 and and CC 10_1101-2021_01_06_425584 127 38 contributes contribute VBZ 10_1101-2021_01_06_425584 127 39 in in IN 10_1101-2021_01_06_425584 127 40 245 245 CD 10_1101-2021_01_06_425584 127 41 reducing reduce VBG 10_1101-2021_01_06_425584 127 42 false false JJ 10_1101-2021_01_06_425584 127 43 positives positive NNS 10_1101-2021_01_06_425584 127 44 . . . 10_1101-2021_01_06_425584 128 1 For for IN 10_1101-2021_01_06_425584 128 2 multivariate multivariate JJ 10_1101-2021_01_06_425584 128 3 statistical statistical JJ 10_1101-2021_01_06_425584 128 4 analysis analysis NN 10_1101-2021_01_06_425584 128 5 and and CC 10_1101-2021_01_06_425584 128 6 heatmap heatmap NNP 10_1101-2021_01_06_425584 128 7 visualization visualization NNP 10_1101-2021_01_06_425584 128 8 , , , 10_1101-2021_01_06_425584 128 9 246 246 CD 10_1101-2021_01_06_425584 128 10 Metaboanalyst Metaboanalyst NNP 10_1101-2021_01_06_425584 128 11 4.0 4.0 CD 10_1101-2021_01_06_425584 128 12 ( ( -LRB- 10_1101-2021_01_06_425584 128 13 https://www.metaboanalyst.ca https://www.metaboanalyst.ca NNP 10_1101-2021_01_06_425584 128 14 ) ) -RRB- 10_1101-2021_01_06_425584 128 15 was be VBD 10_1101-2021_01_06_425584 128 16 utilized utilize VBN 10_1101-2021_01_06_425584 128 17 . . . 10_1101-2021_01_06_425584 129 1 Principal principal JJ 10_1101-2021_01_06_425584 129 2 component component NN 10_1101-2021_01_06_425584 129 3 analysis analysis NN 10_1101-2021_01_06_425584 129 4 247 247 CD 10_1101-2021_01_06_425584 129 5 ( ( -LRB- 10_1101-2021_01_06_425584 129 6 PCA PCA NNP 10_1101-2021_01_06_425584 129 7 ) ) -RRB- 10_1101-2021_01_06_425584 129 8 was be VBD 10_1101-2021_01_06_425584 129 9 used use VBN 10_1101-2021_01_06_425584 129 10 to to TO 10_1101-2021_01_06_425584 129 11 assess assess VB 10_1101-2021_01_06_425584 129 12 for for IN 10_1101-2021_01_06_425584 129 13 sample sample NN 10_1101-2021_01_06_425584 129 14 clustering cluster VBG 10_1101-2021_01_06_425584 129 15 behavior behavior NN 10_1101-2021_01_06_425584 129 16 and and CC 10_1101-2021_01_06_425584 129 17 inter inter JJ 10_1101-2021_01_06_425584 129 18 - - JJ 10_1101-2021_01_06_425584 129 19 group group JJ 10_1101-2021_01_06_425584 129 20 variation variation NN 10_1101-2021_01_06_425584 129 21 . . . 10_1101-2021_01_06_425584 130 1 No no DT 10_1101-2021_01_06_425584 130 2 scaling scale VBG 10_1101-2021_01_06_425584 130 3 248 248 CD 10_1101-2021_01_06_425584 130 4 was be VBD 10_1101-2021_01_06_425584 130 5 used use VBN 10_1101-2021_01_06_425584 130 6 for for IN 10_1101-2021_01_06_425584 130 7 PCA PCA NNP 10_1101-2021_01_06_425584 130 8 and and CC 10_1101-2021_01_06_425584 130 9 heatmap heatmap NNP 10_1101-2021_01_06_425584 130 10 analysis analysis NN 10_1101-2021_01_06_425584 130 11 . . . 10_1101-2021_01_06_425584 131 1 Software software NN 10_1101-2021_01_06_425584 131 2 PRISM prism NN 10_1101-2021_01_06_425584 131 3 6.0 6.0 CD 10_1101-2021_01_06_425584 131 4 ( ( -LRB- 10_1101-2021_01_06_425584 131 5 GraphPad GraphPad NNP 10_1101-2021_01_06_425584 131 6 Software Software NNP 10_1101-2021_01_06_425584 131 7 , , , 10_1101-2021_01_06_425584 131 8 San San NNP 10_1101-2021_01_06_425584 131 9 Diego Diego NNP 10_1101-2021_01_06_425584 131 10 , , , 10_1101-2021_01_06_425584 131 11 249 249 CD 10_1101-2021_01_06_425584 131 12 CA CA NNP 10_1101-2021_01_06_425584 131 13 ) ) -RRB- 10_1101-2021_01_06_425584 131 14 was be VBD 10_1101-2021_01_06_425584 131 15 used use VBN 10_1101-2021_01_06_425584 131 16 for for IN 10_1101-2021_01_06_425584 131 17 the the DT 10_1101-2021_01_06_425584 131 18 creation creation NN 10_1101-2021_01_06_425584 131 19 of of IN 10_1101-2021_01_06_425584 131 20 volcano volcano NN 10_1101-2021_01_06_425584 131 21 plots plot NNS 10_1101-2021_01_06_425584 131 22 and and CC 10_1101-2021_01_06_425584 131 23 column column NN 10_1101-2021_01_06_425584 131 24 graphs graphs NN 10_1101-2021_01_06_425584 131 25 . . . 10_1101-2021_01_06_425584 132 1 250 250 CD 10_1101-2021_01_06_425584 132 2 251 251 CD 10_1101-2021_01_06_425584 132 3 2.12 2.12 CD 10_1101-2021_01_06_425584 132 4 Data datum NNS 10_1101-2021_01_06_425584 132 5 availability availability NN 10_1101-2021_01_06_425584 132 6 252 252 CD 10_1101-2021_01_06_425584 132 7 .CC .CC NFP 10_1101-2021_01_06_425584 132 8 - - : 10_1101-2021_01_06_425584 132 9 BY by IN 10_1101-2021_01_06_425584 132 10 - - HYPH 10_1101-2021_01_06_425584 132 11 NC NC NNP 10_1101-2021_01_06_425584 132 12 - - HYPH 10_1101-2021_01_06_425584 132 13 ND ND NNP 10_1101-2021_01_06_425584 132 14 4.0 4.0 CD 10_1101-2021_01_06_425584 132 15 International International NNP 10_1101-2021_01_06_425584 132 16 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 132 17 under under IN 10_1101-2021_01_06_425584 132 18 a a DT 10_1101-2021_01_06_425584 132 19 ( ( -LRB- 10_1101-2021_01_06_425584 132 20 which which WDT 10_1101-2021_01_06_425584 132 21 was be VBD 10_1101-2021_01_06_425584 132 22 not not RB 10_1101-2021_01_06_425584 132 23 certified certify VBN 10_1101-2021_01_06_425584 132 24 by by IN 10_1101-2021_01_06_425584 132 25 peer peer NN 10_1101-2021_01_06_425584 132 26 review review NN 10_1101-2021_01_06_425584 132 27 ) ) -RRB- 10_1101-2021_01_06_425584 132 28 is be VBZ 10_1101-2021_01_06_425584 132 29 the the DT 10_1101-2021_01_06_425584 132 30 author author NN 10_1101-2021_01_06_425584 132 31 / / SYM 10_1101-2021_01_06_425584 132 32 funder funder NN 10_1101-2021_01_06_425584 132 33 , , , 10_1101-2021_01_06_425584 132 34 who who WP 10_1101-2021_01_06_425584 132 35 has have VBZ 10_1101-2021_01_06_425584 132 36 granted grant VBN 10_1101-2021_01_06_425584 132 37 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 132 38 a a DT 10_1101-2021_01_06_425584 132 39 license license NN 10_1101-2021_01_06_425584 132 40 to to TO 10_1101-2021_01_06_425584 132 41 display display VB 10_1101-2021_01_06_425584 132 42 the the DT 10_1101-2021_01_06_425584 132 43 preprint preprint NN 10_1101-2021_01_06_425584 132 44 in in IN 10_1101-2021_01_06_425584 132 45 perpetuity perpetuity NN 10_1101-2021_01_06_425584 132 46 . . . 10_1101-2021_01_06_425584 133 1 It -PRON- PRP 10_1101-2021_01_06_425584 133 2 is be VBZ 10_1101-2021_01_06_425584 133 3 made make VBN 10_1101-2021_01_06_425584 133 4 The the DT 10_1101-2021_01_06_425584 133 5 copyright copyright NN 10_1101-2021_01_06_425584 133 6 holder holder NN 10_1101-2021_01_06_425584 133 7 for for IN 10_1101-2021_01_06_425584 133 8 this this DT 10_1101-2021_01_06_425584 133 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 133 10 version version NN 10_1101-2021_01_06_425584 133 11 posted post VBD 10_1101-2021_01_06_425584 133 12 January January NNP 10_1101-2021_01_06_425584 133 13 8 8 CD 10_1101-2021_01_06_425584 133 14 , , , 10_1101-2021_01_06_425584 133 15 2021 2021 CD 10_1101-2021_01_06_425584 133 16 . . . 10_1101-2021_01_06_425584 133 17 ; ; : 10_1101-2021_01_06_425584 133 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 133 19 : : : 10_1101-2021_01_06_425584 133 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 133 21 preprint preprint NN 10_1101-2021_01_06_425584 133 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 133 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 133 24 9 9 CD 10_1101-2021_01_06_425584 133 25 The the DT 10_1101-2021_01_06_425584 133 26 raw raw JJ 10_1101-2021_01_06_425584 133 27 datasets dataset NNS 10_1101-2021_01_06_425584 133 28 supporting support VBG 10_1101-2021_01_06_425584 133 29 the the DT 10_1101-2021_01_06_425584 133 30 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 133 31 results result NNS 10_1101-2021_01_06_425584 133 32 are be VBP 10_1101-2021_01_06_425584 133 33 available available JJ 10_1101-2021_01_06_425584 133 34 in in IN 10_1101-2021_01_06_425584 133 35 the the DT 10_1101-2021_01_06_425584 133 36 GNPS GNPS NNP 10_1101-2021_01_06_425584 133 37 / / SYM 10_1101-2021_01_06_425584 133 38 MassIVE MassIVE `` 10_1101-2021_01_06_425584 133 39 public public JJ 10_1101-2021_01_06_425584 133 40 253 253 CD 10_1101-2021_01_06_425584 133 41 repository repository NN 10_1101-2021_01_06_425584 133 42 ( ( -LRB- 10_1101-2021_01_06_425584 133 43 38 38 CD 10_1101-2021_01_06_425584 133 44 ) ) -RRB- 10_1101-2021_01_06_425584 133 45 under under IN 10_1101-2021_01_06_425584 133 46 the the DT 10_1101-2021_01_06_425584 133 47 accession accession NN 10_1101-2021_01_06_425584 133 48 number number NN 10_1101-2021_01_06_425584 133 49 MSV000084307 MSV000084307 NNP 10_1101-2021_01_06_425584 133 50 . . . 10_1101-2021_01_06_425584 134 1 The the DT 10_1101-2021_01_06_425584 134 2 specific specific JJ 10_1101-2021_01_06_425584 134 3 parameters parameter NNS 10_1101-2021_01_06_425584 134 4 of of IN 10_1101-2021_01_06_425584 134 5 the the DT 10_1101-2021_01_06_425584 134 6 tools tool NNS 10_1101-2021_01_06_425584 134 7 254 254 CD 10_1101-2021_01_06_425584 134 8 employed employ VBN 10_1101-2021_01_06_425584 134 9 for for IN 10_1101-2021_01_06_425584 134 10 metabolite metabolite JJ 10_1101-2021_01_06_425584 134 11 annotation annotation NN 10_1101-2021_01_06_425584 134 12 are be VBP 10_1101-2021_01_06_425584 134 13 available available JJ 10_1101-2021_01_06_425584 134 14 on on IN 10_1101-2021_01_06_425584 134 15 the the DT 10_1101-2021_01_06_425584 134 16 following follow VBG 10_1101-2021_01_06_425584 134 17 links link NNS 10_1101-2021_01_06_425584 134 18 : : : 10_1101-2021_01_06_425584 134 19 for for IN 10_1101-2021_01_06_425584 134 20 classical classical NNP 10_1101-2021_01_06_425584 134 21 molecular molecular NNP 10_1101-2021_01_06_425584 134 22 255 255 CD 10_1101-2021_01_06_425584 134 23 networking networking NN 10_1101-2021_01_06_425584 134 24 , , , 10_1101-2021_01_06_425584 134 25 256 256 CD 10_1101-2021_01_06_425584 134 26 https://gnps.ucsd.edu/ProteoSAFe/status.jsp?task=604b3d077e00430a9bc288eebf154b9b https://gnps.ucsd.edu/ProteoSAFe/status.jsp?task=604b3d077e00430a9bc288eebf154b9b NNP 10_1101-2021_01_06_425584 134 27 ; ; : 10_1101-2021_01_06_425584 134 28 for for IN 10_1101-2021_01_06_425584 134 29 257 257 CD 10_1101-2021_01_06_425584 134 30 FBMN FBMN NNP 10_1101-2021_01_06_425584 134 31 258 258 CD 10_1101-2021_01_06_425584 134 32 https://gnps.ucsd.edu/ProteoSAFe/status.jsp?task=5e2839037969442e868d9df21309d561 https://gnps.ucsd.edu/proteosafe/status.jsp?task=5e2839037969442e868d9df21309d561 NN 10_1101-2021_01_06_425584 134 33 ; ; : 10_1101-2021_01_06_425584 134 34 for for IN 10_1101-2021_01_06_425584 134 35 259 259 CD 10_1101-2021_01_06_425584 134 36 NAP NAP NNP 10_1101-2021_01_06_425584 134 37 , , , 10_1101-2021_01_06_425584 134 38 260 260 CD 10_1101-2021_01_06_425584 134 39 https://proteomics2.ucsd.edu/ProteoSAFe/status.jsp?task=96cda48c0df64d3398a8f9088907afb261 https://proteomics2.ucsd.edu/ProteoSAFe/status.jsp?task=96cda48c0df64d3398a8f9088907afb261 NNPS 10_1101-2021_01_06_425584 134 40 5 5 CD 10_1101-2021_01_06_425584 134 41 ; ; : 10_1101-2021_01_06_425584 134 42 for for IN 10_1101-2021_01_06_425584 134 43 MS2LDA MS2LDA NNP 10_1101-2021_01_06_425584 134 44 , , , 10_1101-2021_01_06_425584 134 45 http://ms2lda.org/basicviz/summary/1197/ http://ms2lda.org/basicviz/summary/1197/ ADD 10_1101-2021_01_06_425584 134 46 ( ( -LRB- 10_1101-2021_01_06_425584 134 47 need need VBP 10_1101-2021_01_06_425584 134 48 to to TO 10_1101-2021_01_06_425584 134 49 log log VB 10_1101-2021_01_06_425584 134 50 - - HYPH 10_1101-2021_01_06_425584 134 51 in in RP 10_1101-2021_01_06_425584 134 52 as as IN 10_1101-2021_01_06_425584 134 53 a a DT 10_1101-2021_01_06_425584 134 54 registered registered JJ 10_1101-2021_01_06_425584 134 55 or or CC 10_1101-2021_01_06_425584 134 56 guest guest NN 10_1101-2021_01_06_425584 134 57 262 262 CD 10_1101-2021_01_06_425584 134 58 user user NN 10_1101-2021_01_06_425584 134 59 ) ) -RRB- 10_1101-2021_01_06_425584 134 60 ; ; : 10_1101-2021_01_06_425584 134 61 for for IN 10_1101-2021_01_06_425584 134 62 MolNetEnhancer MolNetEnhancer NNP 10_1101-2021_01_06_425584 134 63 , , , 10_1101-2021_01_06_425584 134 64 263 263 CD 10_1101-2021_01_06_425584 134 65 https://gnps.ucsd.edu/ProteoSAFe/status.jsp?task=de80b9c765e042ffab7767a3101054fd https://gnps.ucsd.edu/proteosafe/status.jsp?task=de80b9c765e042ffab7767a3101054fd CD 10_1101-2021_01_06_425584 134 66 . . . 10_1101-2021_01_06_425584 135 1 The the DT 10_1101-2021_01_06_425584 135 2 264 264 CD 10_1101-2021_01_06_425584 135 3 quantitative quantitative JJ 10_1101-2021_01_06_425584 135 4 results result NNS 10_1101-2021_01_06_425584 135 5 generated generate VBN 10_1101-2021_01_06_425584 135 6 using use VBG 10_1101-2021_01_06_425584 135 7 the the DT 10_1101-2021_01_06_425584 135 8 XCMS XCMS NNP 10_1101-2021_01_06_425584 135 9 platform platform NN 10_1101-2021_01_06_425584 135 10 can can MD 10_1101-2021_01_06_425584 135 11 be be VB 10_1101-2021_01_06_425584 135 12 accessed access VBN 10_1101-2021_01_06_425584 135 13 after after IN 10_1101-2021_01_06_425584 135 14 logging log VBG 10_1101-2021_01_06_425584 135 15 into into IN 10_1101-2021_01_06_425584 135 16 the the DT 10_1101-2021_01_06_425584 135 17 265 265 CD 10_1101-2021_01_06_425584 135 18 following follow VBG 10_1101-2021_01_06_425584 135 19 link link NN 10_1101-2021_01_06_425584 135 20 https://xcmsonline.scripps.edu https://xcmsonline.scripps.edu NNS 10_1101-2021_01_06_425584 135 21 and and CC 10_1101-2021_01_06_425584 135 22 searching search VBG 10_1101-2021_01_06_425584 135 23 for for IN 10_1101-2021_01_06_425584 135 24 the the DT 10_1101-2021_01_06_425584 135 25 job job NN 10_1101-2021_01_06_425584 135 26 number number NN 10_1101-2021_01_06_425584 135 27 1395724 1395724 CD 10_1101-2021_01_06_425584 135 28 . . . 10_1101-2021_01_06_425584 136 1 SWATH SWATH NNP 10_1101-2021_01_06_425584 136 2 266 266 CD 10_1101-2021_01_06_425584 136 3 data datum NNS 10_1101-2021_01_06_425584 136 4 is be VBZ 10_1101-2021_01_06_425584 136 5 accessible accessible JJ 10_1101-2021_01_06_425584 136 6 on on IN 10_1101-2021_01_06_425584 136 7 the the DT 10_1101-2021_01_06_425584 136 8 ProteomeXchange ProteomeXchange NNP 10_1101-2021_01_06_425584 136 9 with with IN 10_1101-2021_01_06_425584 136 10 dataset dataset NN 10_1101-2021_01_06_425584 136 11 identifier identifier NN 10_1101-2021_01_06_425584 136 12 PXD013643 PXD013643 NNP 10_1101-2021_01_06_425584 136 13 . . . 10_1101-2021_01_06_425584 137 1 267 267 CD 10_1101-2021_01_06_425584 137 2 268 268 CD 10_1101-2021_01_06_425584 137 3 3 3 CD 10_1101-2021_01_06_425584 137 4 . . . 10_1101-2021_01_06_425584 138 1 Results result NNS 10_1101-2021_01_06_425584 138 2 269 269 CD 10_1101-2021_01_06_425584 138 3 270 270 CD 10_1101-2021_01_06_425584 138 4 Untargeted untargeted JJ 10_1101-2021_01_06_425584 138 5 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 138 6 271 271 CD 10_1101-2021_01_06_425584 138 7 Overall overall JJ 10_1101-2021_01_06_425584 138 8 5571 5571 CD 10_1101-2021_01_06_425584 138 9 features feature NNS 10_1101-2021_01_06_425584 138 10 or or CC 10_1101-2021_01_06_425584 138 11 potential potential JJ 10_1101-2021_01_06_425584 138 12 metabolites metabolite NNS 10_1101-2021_01_06_425584 138 13 were be VBD 10_1101-2021_01_06_425584 138 14 detected detect VBN 10_1101-2021_01_06_425584 138 15 using use VBG 10_1101-2021_01_06_425584 138 16 XCMS XCMS NNP 10_1101-2021_01_06_425584 138 17 and and CC 10_1101-2021_01_06_425584 138 18 MZmine MZmine NNP 10_1101-2021_01_06_425584 138 19 , , , 10_1101-2021_01_06_425584 138 20 wherein wherein WRB 10_1101-2021_01_06_425584 138 21 272 272 CD 10_1101-2021_01_06_425584 138 22 957 957 CD 10_1101-2021_01_06_425584 138 23 ( ( -LRB- 10_1101-2021_01_06_425584 138 24 ~18 ~18 NFP 10_1101-2021_01_06_425584 138 25 % % NN 10_1101-2021_01_06_425584 138 26 ) ) -RRB- 10_1101-2021_01_06_425584 138 27 features feature NNS 10_1101-2021_01_06_425584 138 28 were be VBD 10_1101-2021_01_06_425584 138 29 commonly commonly RB 10_1101-2021_01_06_425584 138 30 identified identify VBN 10_1101-2021_01_06_425584 138 31 in in IN 10_1101-2021_01_06_425584 138 32 both both DT 10_1101-2021_01_06_425584 138 33 platforms platform NNS 10_1101-2021_01_06_425584 138 34 ( ( -LRB- 10_1101-2021_01_06_425584 138 35 Figure Figure NNP 10_1101-2021_01_06_425584 138 36 2A 2a NN 10_1101-2021_01_06_425584 138 37 ) ) -RRB- 10_1101-2021_01_06_425584 138 38 . . . 10_1101-2021_01_06_425584 139 1 Based base VBN 10_1101-2021_01_06_425584 139 2 on on IN 10_1101-2021_01_06_425584 139 3 the the DT 10_1101-2021_01_06_425584 139 4 273 273 CD 10_1101-2021_01_06_425584 139 5 relative relative JJ 10_1101-2021_01_06_425584 139 6 quantification quantification NN 10_1101-2021_01_06_425584 139 7 using use VBG 10_1101-2021_01_06_425584 139 8 XCMS XCMS NNP 10_1101-2021_01_06_425584 139 9 , , , 10_1101-2021_01_06_425584 139 10 140 140 CD 10_1101-2021_01_06_425584 139 11 and and CC 10_1101-2021_01_06_425584 139 12 82 82 CD 10_1101-2021_01_06_425584 139 13 features feature NNS 10_1101-2021_01_06_425584 139 14 were be VBD 10_1101-2021_01_06_425584 139 15 detected detect VBN 10_1101-2021_01_06_425584 139 16 with with IN 10_1101-2021_01_06_425584 139 17 reduced reduced JJ 10_1101-2021_01_06_425584 139 18 and and CC 10_1101-2021_01_06_425584 139 19 274 274 CD 10_1101-2021_01_06_425584 139 20 increased increase VBN 10_1101-2021_01_06_425584 139 21 abundances abundance NNS 10_1101-2021_01_06_425584 139 22 respectively respectively RB 10_1101-2021_01_06_425584 139 23 in in IN 10_1101-2021_01_06_425584 139 24 the the DT 10_1101-2021_01_06_425584 139 25 experimental experimental JJ 10_1101-2021_01_06_425584 139 26 group group NN 10_1101-2021_01_06_425584 139 27 compared compare VBN 10_1101-2021_01_06_425584 139 28 to to IN 10_1101-2021_01_06_425584 139 29 the the DT 10_1101-2021_01_06_425584 139 30 control control NN 10_1101-2021_01_06_425584 139 31 group group NN 10_1101-2021_01_06_425584 139 32 275 275 CD 10_1101-2021_01_06_425584 139 33 ( ( -LRB- 10_1101-2021_01_06_425584 139 34 Figure figure NN 10_1101-2021_01_06_425584 139 35 2B 2B NNS 10_1101-2021_01_06_425584 139 36 ) ) -RRB- 10_1101-2021_01_06_425584 139 37 . . . 10_1101-2021_01_06_425584 140 1 The the DT 10_1101-2021_01_06_425584 140 2 effects effect NNS 10_1101-2021_01_06_425584 140 3 of of IN 10_1101-2021_01_06_425584 140 4 HG HG NNP 10_1101-2021_01_06_425584 140 5 and and CC 10_1101-2021_01_06_425584 140 6 HI HI NNP 10_1101-2021_01_06_425584 140 7 in in IN 10_1101-2021_01_06_425584 140 8 the the DT 10_1101-2021_01_06_425584 140 9 experimental experimental JJ 10_1101-2021_01_06_425584 140 10 group group NN 10_1101-2021_01_06_425584 140 11 are be VBP 10_1101-2021_01_06_425584 140 12 observed observe VBN 10_1101-2021_01_06_425584 140 13 by by IN 10_1101-2021_01_06_425584 140 14 PCA PCA NNP 10_1101-2021_01_06_425584 140 15 analysis analysis NN 10_1101-2021_01_06_425584 140 16 276 276 CD 10_1101-2021_01_06_425584 140 17 wherein wherein WRB 10_1101-2021_01_06_425584 140 18 the the DT 10_1101-2021_01_06_425584 140 19 experimental experimental JJ 10_1101-2021_01_06_425584 140 20 samples sample NNS 10_1101-2021_01_06_425584 140 21 clustered cluster VBN 10_1101-2021_01_06_425584 140 22 away away RB 10_1101-2021_01_06_425584 140 23 from from IN 10_1101-2021_01_06_425584 140 24 the the DT 10_1101-2021_01_06_425584 140 25 control control NN 10_1101-2021_01_06_425584 140 26 group group NN 10_1101-2021_01_06_425584 140 27 ( ( -LRB- 10_1101-2021_01_06_425584 140 28 Figure figure NN 10_1101-2021_01_06_425584 140 29 2C 2c NN 10_1101-2021_01_06_425584 140 30 ) ) -RRB- 10_1101-2021_01_06_425584 140 31 . . . 10_1101-2021_01_06_425584 141 1 The the DT 10_1101-2021_01_06_425584 141 2 277 277 CD 10_1101-2021_01_06_425584 141 3 consistency consistency NN 10_1101-2021_01_06_425584 141 4 of of IN 10_1101-2021_01_06_425584 141 5 the the DT 10_1101-2021_01_06_425584 141 6 LC LC NNP 10_1101-2021_01_06_425584 141 7 - - HYPH 10_1101-2021_01_06_425584 141 8 MS MS NNP 10_1101-2021_01_06_425584 141 9 equipment equipment NN 10_1101-2021_01_06_425584 141 10 is be VBZ 10_1101-2021_01_06_425584 141 11 apparent apparent JJ 10_1101-2021_01_06_425584 141 12 by by IN 10_1101-2021_01_06_425584 141 13 the the DT 10_1101-2021_01_06_425584 141 14 clustering clustering NN 10_1101-2021_01_06_425584 141 15 of of IN 10_1101-2021_01_06_425584 141 16 the the DT 10_1101-2021_01_06_425584 141 17 QC QC NNP 10_1101-2021_01_06_425584 141 18 samples sample NNS 10_1101-2021_01_06_425584 141 19 ( ( -LRB- 10_1101-2021_01_06_425584 141 20 Figure figure NN 10_1101-2021_01_06_425584 141 21 278 278 CD 10_1101-2021_01_06_425584 141 22 2C 2c NN 10_1101-2021_01_06_425584 141 23 ) ) -RRB- 10_1101-2021_01_06_425584 141 24 . . . 10_1101-2021_01_06_425584 142 1 Further further RB 10_1101-2021_01_06_425584 142 2 , , , 10_1101-2021_01_06_425584 142 3 the the DT 10_1101-2021_01_06_425584 142 4 heatmap heatmap NN 10_1101-2021_01_06_425584 142 5 visualization visualization NN 10_1101-2021_01_06_425584 142 6 of of IN 10_1101-2021_01_06_425584 142 7 the the DT 10_1101-2021_01_06_425584 142 8 top top JJ 10_1101-2021_01_06_425584 142 9 100-modulated 100-modulated CD 10_1101-2021_01_06_425584 142 10 metabolites metabolite NNS 10_1101-2021_01_06_425584 142 11 exhibited exhibit VBD 10_1101-2021_01_06_425584 142 12 the the DT 10_1101-2021_01_06_425584 142 13 279 279 CD 10_1101-2021_01_06_425584 142 14 different different JJ 10_1101-2021_01_06_425584 142 15 distribution distribution NN 10_1101-2021_01_06_425584 142 16 patterns pattern NNS 10_1101-2021_01_06_425584 142 17 among among IN 10_1101-2021_01_06_425584 142 18 groups group NNS 10_1101-2021_01_06_425584 142 19 ( ( -LRB- 10_1101-2021_01_06_425584 142 20 Figure figure NN 10_1101-2021_01_06_425584 142 21 2D 2d NN 10_1101-2021_01_06_425584 142 22 ) ) -RRB- 10_1101-2021_01_06_425584 142 23 . . . 10_1101-2021_01_06_425584 143 1 Using use VBG 10_1101-2021_01_06_425584 143 2 the the DT 10_1101-2021_01_06_425584 143 3 GNPS gnps NN 10_1101-2021_01_06_425584 143 4 platform platform NN 10_1101-2021_01_06_425584 143 5 for for IN 10_1101-2021_01_06_425584 143 6 automatic automatic JJ 10_1101-2021_01_06_425584 143 7 280 280 CD 10_1101-2021_01_06_425584 143 8 metabolite metabolite JJ 10_1101-2021_01_06_425584 143 9 annotation annotation NN 10_1101-2021_01_06_425584 143 10 , , , 10_1101-2021_01_06_425584 143 11 106 106 CD 10_1101-2021_01_06_425584 143 12 compounds compound NNS 10_1101-2021_01_06_425584 143 13 ( ( -LRB- 10_1101-2021_01_06_425584 143 14 excluding exclude VBG 10_1101-2021_01_06_425584 143 15 duplicates duplicate NNS 10_1101-2021_01_06_425584 143 16 and and CC 10_1101-2021_01_06_425584 143 17 contaminants contaminant NNS 10_1101-2021_01_06_425584 143 18 ) ) -RRB- 10_1101-2021_01_06_425584 143 19 were be VBD 10_1101-2021_01_06_425584 143 20 putatively putatively RB 10_1101-2021_01_06_425584 143 21 281 281 CD 10_1101-2021_01_06_425584 143 22 annotated annotate VBN 10_1101-2021_01_06_425584 143 23 with with IN 10_1101-2021_01_06_425584 143 24 a a DT 10_1101-2021_01_06_425584 143 25 level level NN 10_1101-2021_01_06_425584 143 26 2 2 CD 10_1101-2021_01_06_425584 143 27 confidence confidence NN 10_1101-2021_01_06_425584 143 28 annotation annotation NN 10_1101-2021_01_06_425584 143 29 ( ( -LRB- 10_1101-2021_01_06_425584 143 30 MS2 MS2 NNP 10_1101-2021_01_06_425584 143 31 spectral spectral JJ 10_1101-2021_01_06_425584 143 32 match match NN 10_1101-2021_01_06_425584 143 33 ) ) -RRB- 10_1101-2021_01_06_425584 143 34 ( ( -LRB- 10_1101-2021_01_06_425584 143 35 Table table NN 10_1101-2021_01_06_425584 143 36 S1 s1 NN 10_1101-2021_01_06_425584 143 37 ) ) -RRB- 10_1101-2021_01_06_425584 143 38 in in IN 10_1101-2021_01_06_425584 143 39 agreeance agreeance NN 10_1101-2021_01_06_425584 143 40 282 282 CD 10_1101-2021_01_06_425584 143 41 with with IN 10_1101-2021_01_06_425584 143 42 the the DT 10_1101-2021_01_06_425584 143 43 MSI MSI NNP 10_1101-2021_01_06_425584 143 44 classification classification NN 10_1101-2021_01_06_425584 143 45 ( ( -LRB- 10_1101-2021_01_06_425584 143 46 28 28 CD 10_1101-2021_01_06_425584 143 47 ) ) -RRB- 10_1101-2021_01_06_425584 143 48 . . . 10_1101-2021_01_06_425584 144 1 Some some DT 10_1101-2021_01_06_425584 144 2 metabolites metabolite NNS 10_1101-2021_01_06_425584 144 3 identified identify VBN 10_1101-2021_01_06_425584 144 4 by by IN 10_1101-2021_01_06_425584 144 5 the the DT 10_1101-2021_01_06_425584 144 6 GNPS GNPS NNP 10_1101-2021_01_06_425584 144 7 platform platform NN 10_1101-2021_01_06_425584 144 8 could could MD 10_1101-2021_01_06_425584 144 9 not not RB 10_1101-2021_01_06_425584 144 10 be be VB 10_1101-2021_01_06_425584 144 11 283 283 CD 10_1101-2021_01_06_425584 144 12 quantified quantify VBN 10_1101-2021_01_06_425584 144 13 because because IN 10_1101-2021_01_06_425584 144 14 they -PRON- PRP 10_1101-2021_01_06_425584 144 15 were be VBD 10_1101-2021_01_06_425584 144 16 not not RB 10_1101-2021_01_06_425584 144 17 detected detect VBN 10_1101-2021_01_06_425584 144 18 by by IN 10_1101-2021_01_06_425584 144 19 the the DT 10_1101-2021_01_06_425584 144 20 XCMS XCMS NNP 10_1101-2021_01_06_425584 144 21 algorithm algorithm NN 10_1101-2021_01_06_425584 144 22 during during IN 10_1101-2021_01_06_425584 144 23 feature feature NN 10_1101-2021_01_06_425584 144 24 area area NN 10_1101-2021_01_06_425584 144 25 284 284 CD 10_1101-2021_01_06_425584 144 26 normalization normalization NN 10_1101-2021_01_06_425584 144 27 and and CC 10_1101-2021_01_06_425584 144 28 quantification quantification NN 10_1101-2021_01_06_425584 144 29 . . . 10_1101-2021_01_06_425584 145 1 Moreover moreover RB 10_1101-2021_01_06_425584 145 2 , , , 10_1101-2021_01_06_425584 145 3 GNPS GNPS NNP 10_1101-2021_01_06_425584 145 4 Molecular Molecular NNP 10_1101-2021_01_06_425584 145 5 Networking Networking NNP 10_1101-2021_01_06_425584 145 6 aligned align VBD 10_1101-2021_01_06_425584 145 7 the the DT 10_1101-2021_01_06_425584 145 8 MS2 MS2 NNP 10_1101-2021_01_06_425584 145 9 - - HYPH 10_1101-2021_01_06_425584 145 10 285 285 NNP 10_1101-2021_01_06_425584 145 11 containing contain VBG 10_1101-2021_01_06_425584 145 12 features feature NNS 10_1101-2021_01_06_425584 145 13 ( ( -LRB- 10_1101-2021_01_06_425584 145 14 n=1,013 n=1,013 NNP 10_1101-2021_01_06_425584 145 15 ) ) -RRB- 10_1101-2021_01_06_425584 145 16 based base VBN 10_1101-2021_01_06_425584 145 17 on on IN 10_1101-2021_01_06_425584 145 18 their -PRON- PRP$ 10_1101-2021_01_06_425584 145 19 structural structural JJ 10_1101-2021_01_06_425584 145 20 similarity similarity NN 10_1101-2021_01_06_425584 145 21 , , , 10_1101-2021_01_06_425584 145 22 creating create VBG 10_1101-2021_01_06_425584 145 23 118 118 CD 10_1101-2021_01_06_425584 145 24 independent independent JJ 10_1101-2021_01_06_425584 145 25 286 286 CD 10_1101-2021_01_06_425584 145 26 networks network NNS 10_1101-2021_01_06_425584 145 27 or or CC 10_1101-2021_01_06_425584 145 28 clusters cluster NNS 10_1101-2021_01_06_425584 145 29 with with IN 10_1101-2021_01_06_425584 145 30 at at RB 10_1101-2021_01_06_425584 145 31 least least RBS 10_1101-2021_01_06_425584 145 32 two two CD 10_1101-2021_01_06_425584 145 33 connected connect VBN 10_1101-2021_01_06_425584 145 34 nodes node NNS 10_1101-2021_01_06_425584 145 35 ( ( -LRB- 10_1101-2021_01_06_425584 145 36 Figure Figure NNP 10_1101-2021_01_06_425584 145 37 3A 3a NN 10_1101-2021_01_06_425584 145 38 ) ) -RRB- 10_1101-2021_01_06_425584 145 39 . . . 10_1101-2021_01_06_425584 146 1 The the DT 10_1101-2021_01_06_425584 146 2 use use NN 10_1101-2021_01_06_425584 146 3 of of IN 10_1101-2021_01_06_425584 146 4 MolNetEnhancer MolNetEnhancer NNP 10_1101-2021_01_06_425584 146 5 287 287 CD 10_1101-2021_01_06_425584 146 6 .CC .CC NFP 10_1101-2021_01_06_425584 146 7 - - HYPH 10_1101-2021_01_06_425584 146 8 BY by IN 10_1101-2021_01_06_425584 146 9 - - HYPH 10_1101-2021_01_06_425584 146 10 NC NC NNP 10_1101-2021_01_06_425584 146 11 - - HYPH 10_1101-2021_01_06_425584 146 12 ND ND NNP 10_1101-2021_01_06_425584 146 13 4.0 4.0 CD 10_1101-2021_01_06_425584 146 14 International International NNP 10_1101-2021_01_06_425584 146 15 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 146 16 under under IN 10_1101-2021_01_06_425584 146 17 a a DT 10_1101-2021_01_06_425584 146 18 ( ( -LRB- 10_1101-2021_01_06_425584 146 19 which which WDT 10_1101-2021_01_06_425584 146 20 was be VBD 10_1101-2021_01_06_425584 146 21 not not RB 10_1101-2021_01_06_425584 146 22 certified certify VBN 10_1101-2021_01_06_425584 146 23 by by IN 10_1101-2021_01_06_425584 146 24 peer peer NN 10_1101-2021_01_06_425584 146 25 review review NN 10_1101-2021_01_06_425584 146 26 ) ) -RRB- 10_1101-2021_01_06_425584 146 27 is be VBZ 10_1101-2021_01_06_425584 146 28 the the DT 10_1101-2021_01_06_425584 146 29 author author NN 10_1101-2021_01_06_425584 146 30 / / SYM 10_1101-2021_01_06_425584 146 31 funder funder NN 10_1101-2021_01_06_425584 146 32 , , , 10_1101-2021_01_06_425584 146 33 who who WP 10_1101-2021_01_06_425584 146 34 has have VBZ 10_1101-2021_01_06_425584 146 35 granted grant VBN 10_1101-2021_01_06_425584 146 36 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 146 37 a a DT 10_1101-2021_01_06_425584 146 38 license license NN 10_1101-2021_01_06_425584 146 39 to to TO 10_1101-2021_01_06_425584 146 40 display display VB 10_1101-2021_01_06_425584 146 41 the the DT 10_1101-2021_01_06_425584 146 42 preprint preprint NN 10_1101-2021_01_06_425584 146 43 in in IN 10_1101-2021_01_06_425584 146 44 perpetuity perpetuity NN 10_1101-2021_01_06_425584 146 45 . . . 10_1101-2021_01_06_425584 147 1 It -PRON- PRP 10_1101-2021_01_06_425584 147 2 is be VBZ 10_1101-2021_01_06_425584 147 3 made make VBN 10_1101-2021_01_06_425584 147 4 The the DT 10_1101-2021_01_06_425584 147 5 copyright copyright NN 10_1101-2021_01_06_425584 147 6 holder holder NN 10_1101-2021_01_06_425584 147 7 for for IN 10_1101-2021_01_06_425584 147 8 this this DT 10_1101-2021_01_06_425584 147 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 147 10 version version NN 10_1101-2021_01_06_425584 147 11 posted post VBD 10_1101-2021_01_06_425584 147 12 January January NNP 10_1101-2021_01_06_425584 147 13 8 8 CD 10_1101-2021_01_06_425584 147 14 , , , 10_1101-2021_01_06_425584 147 15 2021 2021 CD 10_1101-2021_01_06_425584 147 16 . . . 10_1101-2021_01_06_425584 147 17 ; ; : 10_1101-2021_01_06_425584 147 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 147 19 : : : 10_1101-2021_01_06_425584 147 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 147 21 preprint preprint NN 10_1101-2021_01_06_425584 147 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 147 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 147 24 10 10 CD 10_1101-2021_01_06_425584 147 25 workflow workflow NN 10_1101-2021_01_06_425584 147 26 allowed allow VBN 10_1101-2021_01_06_425584 147 27 to to TO 10_1101-2021_01_06_425584 147 28 putatively putatively RB 10_1101-2021_01_06_425584 147 29 identify identify VB 10_1101-2021_01_06_425584 147 30 chemical chemical NN 10_1101-2021_01_06_425584 147 31 classes class NNS 10_1101-2021_01_06_425584 147 32 ( ( -LRB- 10_1101-2021_01_06_425584 147 33 level level NN 10_1101-2021_01_06_425584 147 34 3 3 CD 10_1101-2021_01_06_425584 147 35 , , , 10_1101-2021_01_06_425584 147 36 MSI MSI NNP 10_1101-2021_01_06_425584 147 37 ) ) -RRB- 10_1101-2021_01_06_425584 147 38 for for IN 10_1101-2021_01_06_425584 147 39 56 56 CD 10_1101-2021_01_06_425584 147 40 of of IN 10_1101-2021_01_06_425584 147 41 the the DT 10_1101-2021_01_06_425584 147 42 118 118 CD 10_1101-2021_01_06_425584 147 43 288 288 CD 10_1101-2021_01_06_425584 147 44 independent independent JJ 10_1101-2021_01_06_425584 147 45 networks network NNS 10_1101-2021_01_06_425584 147 46 . . . 10_1101-2021_01_06_425584 148 1 The the DT 10_1101-2021_01_06_425584 148 2 top-10 top-10 JJ 10_1101-2021_01_06_425584 148 3 most most RBS 10_1101-2021_01_06_425584 148 4 abundant abundant JJ 10_1101-2021_01_06_425584 148 5 annotated annotate VBN 10_1101-2021_01_06_425584 148 6 chemical chemical NN 10_1101-2021_01_06_425584 148 7 classes class NNS 10_1101-2021_01_06_425584 148 8 and and CC 10_1101-2021_01_06_425584 148 9 associated associate VBD 10_1101-2021_01_06_425584 148 10 289 289 CD 10_1101-2021_01_06_425584 148 11 metabolites metabolite NNS 10_1101-2021_01_06_425584 148 12 are be VBP 10_1101-2021_01_06_425584 148 13 shown show VBN 10_1101-2021_01_06_425584 148 14 in in IN 10_1101-2021_01_06_425584 148 15 Figure figure NN 10_1101-2021_01_06_425584 148 16 3A. 3a. CD 10_1101-2021_01_06_425584 149 1 Three three CD 10_1101-2021_01_06_425584 149 2 - - HYPH 10_1101-2021_01_06_425584 149 3 clusters cluster NNS 10_1101-2021_01_06_425584 149 4 from from IN 10_1101-2021_01_06_425584 149 5 the the DT 10_1101-2021_01_06_425584 149 6 network network NN 10_1101-2021_01_06_425584 149 7 were be VBD 10_1101-2021_01_06_425584 149 8 further further RB 10_1101-2021_01_06_425584 149 9 analyzed analyze VBN 10_1101-2021_01_06_425584 149 10 290 290 CD 10_1101-2021_01_06_425584 149 11 because because IN 10_1101-2021_01_06_425584 149 12 they -PRON- PRP 10_1101-2021_01_06_425584 149 13 contained contain VBD 10_1101-2021_01_06_425584 149 14 annotated annotate VBN 10_1101-2021_01_06_425584 149 15 metabolites metabolite NNS 10_1101-2021_01_06_425584 149 16 by by IN 10_1101-2021_01_06_425584 149 17 spectral spectral JJ 10_1101-2021_01_06_425584 149 18 matching matching NN 10_1101-2021_01_06_425584 149 19 , , , 10_1101-2021_01_06_425584 149 20 which which WDT 10_1101-2021_01_06_425584 149 21 facilitates facilitate VBZ 10_1101-2021_01_06_425584 149 22 the the DT 10_1101-2021_01_06_425584 149 23 291 291 CD 10_1101-2021_01_06_425584 149 24 annotation annotation NN 10_1101-2021_01_06_425584 149 25 of of IN 10_1101-2021_01_06_425584 149 26 other other JJ 10_1101-2021_01_06_425584 149 27 cluster cluster NN 10_1101-2021_01_06_425584 149 28 ’s ’s POS 10_1101-2021_01_06_425584 149 29 nodes node NNS 10_1101-2021_01_06_425584 149 30 . . . 10_1101-2021_01_06_425584 150 1 Cluster Cluster NNP 10_1101-2021_01_06_425584 150 2 1 1 CD 10_1101-2021_01_06_425584 150 3 revealed reveal VBD 10_1101-2021_01_06_425584 150 4 two two CD 10_1101-2021_01_06_425584 150 5 metabolites metabolite NNS 10_1101-2021_01_06_425584 150 6 linked link VBN 10_1101-2021_01_06_425584 150 7 to to IN 10_1101-2021_01_06_425584 150 8 the the DT 10_1101-2021_01_06_425584 150 9 292 292 CD 10_1101-2021_01_06_425584 150 10 organonitrogen organonitrogen NNP 10_1101-2021_01_06_425584 150 11 compounds compound VBZ 10_1101-2021_01_06_425584 150 12 class class NN 10_1101-2021_01_06_425584 150 13 with with IN 10_1101-2021_01_06_425584 150 14 reduced reduce VBN 10_1101-2021_01_06_425584 150 15 abundance abundance NN 10_1101-2021_01_06_425584 150 16 in in IN 10_1101-2021_01_06_425584 150 17 the the DT 10_1101-2021_01_06_425584 150 18 experimental experimental JJ 10_1101-2021_01_06_425584 150 19 group group NN 10_1101-2021_01_06_425584 150 20 ( ( -LRB- 10_1101-2021_01_06_425584 150 21 Figure Figure NNP 10_1101-2021_01_06_425584 150 22 3B 3b NN 10_1101-2021_01_06_425584 150 23 ) ) -RRB- 10_1101-2021_01_06_425584 150 24 . . . 10_1101-2021_01_06_425584 151 1 293 293 CD 10_1101-2021_01_06_425584 151 2 Library library JJ 10_1101-2021_01_06_425584 151 3 spectral spectral NN 10_1101-2021_01_06_425584 151 4 match match NN 10_1101-2021_01_06_425584 151 5 ( ( -LRB- 10_1101-2021_01_06_425584 151 6 level level NN 10_1101-2021_01_06_425584 151 7 2 2 CD 10_1101-2021_01_06_425584 151 8 , , , 10_1101-2021_01_06_425584 151 9 MSI MSI NNP 10_1101-2021_01_06_425584 151 10 ) ) -RRB- 10_1101-2021_01_06_425584 151 11 suggest suggest VBP 10_1101-2021_01_06_425584 151 12 PC(16:0/18:1(9Z pc(16:0/18:1(9z CD 10_1101-2021_01_06_425584 151 13 ) ) -RRB- 10_1101-2021_01_06_425584 151 14 ) ) -RRB- 10_1101-2021_01_06_425584 151 15 and and CC 10_1101-2021_01_06_425584 151 16 PC(18:0/18:2(9Z,12Z PC(18:0/18:2(9Z,12Z NNP 10_1101-2021_01_06_425584 151 17 ) ) -RRB- 10_1101-2021_01_06_425584 151 18 ) ) -RRB- 10_1101-2021_01_06_425584 151 19 as as IN 10_1101-2021_01_06_425584 151 20 294 294 CD 10_1101-2021_01_06_425584 151 21 putative putative JJ 10_1101-2021_01_06_425584 151 22 candidates candidate NNS 10_1101-2021_01_06_425584 151 23 , , , 10_1101-2021_01_06_425584 151 24 which which WDT 10_1101-2021_01_06_425584 151 25 was be VBD 10_1101-2021_01_06_425584 151 26 supported support VBN 10_1101-2021_01_06_425584 151 27 by by IN 10_1101-2021_01_06_425584 151 28 MS2LDA MS2LDA NNP 10_1101-2021_01_06_425584 151 29 phosphocholine phosphocholine NN 10_1101-2021_01_06_425584 151 30 - - HYPH 10_1101-2021_01_06_425584 151 31 substructure substructure NN 10_1101-2021_01_06_425584 151 32 recognition recognition NN 10_1101-2021_01_06_425584 151 33 295 295 CD 10_1101-2021_01_06_425584 151 34 ( ( -LRB- 10_1101-2021_01_06_425584 151 35 Figure figure NN 10_1101-2021_01_06_425584 151 36 3C 3c NN 10_1101-2021_01_06_425584 151 37 ) ) -RRB- 10_1101-2021_01_06_425584 151 38 . . . 10_1101-2021_01_06_425584 152 1 In in IN 10_1101-2021_01_06_425584 152 2 cluster cluster NN 10_1101-2021_01_06_425584 152 3 2 2 CD 10_1101-2021_01_06_425584 152 4 , , , 10_1101-2021_01_06_425584 152 5 glutathione glutathione NN 10_1101-2021_01_06_425584 152 6 - - HYPH 10_1101-2021_01_06_425584 152 7 based base VBN 10_1101-2021_01_06_425584 152 8 metabolites metabolite NNS 10_1101-2021_01_06_425584 152 9 ( ( -LRB- 10_1101-2021_01_06_425584 152 10 MSI MSI NNP 10_1101-2021_01_06_425584 152 11 level level NN 10_1101-2021_01_06_425584 152 12 3 3 CD 10_1101-2021_01_06_425584 152 13 ) ) -RRB- 10_1101-2021_01_06_425584 152 14 were be VBD 10_1101-2021_01_06_425584 152 15 detected detect VBN 10_1101-2021_01_06_425584 152 16 through through IN 10_1101-2021_01_06_425584 152 17 296 296 CD 10_1101-2021_01_06_425584 152 18 fragments fragment NNS 10_1101-2021_01_06_425584 152 19 m m NN 10_1101-2021_01_06_425584 152 20 / / SYM 10_1101-2021_01_06_425584 152 21 z z NNP 10_1101-2021_01_06_425584 152 22 308.0925 308.0925 NN 10_1101-2021_01_06_425584 152 23 , , , 10_1101-2021_01_06_425584 152 24 233.0575 233.0575 CD 10_1101-2021_01_06_425584 152 25 , , , 10_1101-2021_01_06_425584 152 26 179.0475 179.0475 UH 10_1101-2021_01_06_425584 152 27 , , , 10_1101-2021_01_06_425584 152 28 and and CC 10_1101-2021_01_06_425584 152 29 162.0225 162.0225 NN 10_1101-2021_01_06_425584 152 30 retrieved retrieve VBN 10_1101-2021_01_06_425584 152 31 by by IN 10_1101-2021_01_06_425584 152 32 the the DT 10_1101-2021_01_06_425584 152 33 M2M_453 M2M_453 NNP 10_1101-2021_01_06_425584 152 34 297 297 CD 10_1101-2021_01_06_425584 152 35 substructure substructure NN 10_1101-2021_01_06_425584 152 36 and and CC 10_1101-2021_01_06_425584 152 37 associated associate VBN 10_1101-2021_01_06_425584 152 38 with with IN 10_1101-2021_01_06_425584 152 39 glutathione glutathione NN 10_1101-2021_01_06_425584 152 40 structure structure NN 10_1101-2021_01_06_425584 152 41 using use VBG 10_1101-2021_01_06_425584 152 42 mzCloud mzCloud NNP 10_1101-2021_01_06_425584 152 43 in in IN 10_1101-2021_01_06_425584 152 44 silico silico NN 10_1101-2021_01_06_425584 152 45 predictions prediction NNS 10_1101-2021_01_06_425584 152 46 ( ( -LRB- 10_1101-2021_01_06_425584 152 47 Figure Figure NNP 10_1101-2021_01_06_425584 152 48 298 298 CD 10_1101-2021_01_06_425584 152 49 4A 4A NNS 10_1101-2021_01_06_425584 152 50 ) ) -RRB- 10_1101-2021_01_06_425584 152 51 . . . 10_1101-2021_01_06_425584 153 1 The the DT 10_1101-2021_01_06_425584 153 2 precursor precursor NN 10_1101-2021_01_06_425584 153 3 ion ion NN 10_1101-2021_01_06_425584 153 4 at at IN 10_1101-2021_01_06_425584 153 5 m m NNP 10_1101-2021_01_06_425584 153 6 / / SYM 10_1101-2021_01_06_425584 153 7 z z NNP 10_1101-2021_01_06_425584 153 8 713.1472 713.1472 NN 10_1101-2021_01_06_425584 153 9 and and CC 10_1101-2021_01_06_425584 153 10 glutathione glutathione NN 10_1101-2021_01_06_425584 153 11 ( ( -LRB- 10_1101-2021_01_06_425584 153 12 annotated annotate VBN 10_1101-2021_01_06_425584 153 13 at at IN 10_1101-2021_01_06_425584 153 14 level level NN 10_1101-2021_01_06_425584 153 15 2 2 CD 10_1101-2021_01_06_425584 153 16 , , , 10_1101-2021_01_06_425584 153 17 MSI MSI NNP 10_1101-2021_01_06_425584 153 18 ) ) -RRB- 10_1101-2021_01_06_425584 153 19 were be VBD 10_1101-2021_01_06_425584 153 20 detected detect VBN 10_1101-2021_01_06_425584 153 21 299 299 CD 10_1101-2021_01_06_425584 153 22 with with IN 10_1101-2021_01_06_425584 153 23 increased increase VBN 10_1101-2021_01_06_425584 153 24 abundance abundance NN 10_1101-2021_01_06_425584 153 25 in in IN 10_1101-2021_01_06_425584 153 26 the the DT 10_1101-2021_01_06_425584 153 27 experimental experimental JJ 10_1101-2021_01_06_425584 153 28 group group NN 10_1101-2021_01_06_425584 153 29 . . . 10_1101-2021_01_06_425584 154 1 MS2LDA MS2LDA NNP 10_1101-2021_01_06_425584 154 2 visualization visualization NNP 10_1101-2021_01_06_425584 154 3 , , , 10_1101-2021_01_06_425584 154 4 at at IN 10_1101-2021_01_06_425584 154 5 the the DT 10_1101-2021_01_06_425584 154 6 M2 M2 NNP 10_1101-2021_01_06_425584 154 7 M M NNP 10_1101-2021_01_06_425584 154 8 level level NN 10_1101-2021_01_06_425584 154 9 , , , 10_1101-2021_01_06_425584 154 10 300 300 CD 10_1101-2021_01_06_425584 154 11 correlated correlate VBD 10_1101-2021_01_06_425584 154 12 with with IN 10_1101-2021_01_06_425584 154 13 the the DT 10_1101-2021_01_06_425584 154 14 GNPS GNPS NNP 10_1101-2021_01_06_425584 154 15 molecular molecular JJ 10_1101-2021_01_06_425584 154 16 networking networking NN 10_1101-2021_01_06_425584 154 17 clustering clustering NN 10_1101-2021_01_06_425584 154 18 ( ( -LRB- 10_1101-2021_01_06_425584 154 19 Figure figure NN 10_1101-2021_01_06_425584 154 20 4B 4b NN 10_1101-2021_01_06_425584 154 21 ) ) -RRB- 10_1101-2021_01_06_425584 154 22 . . . 10_1101-2021_01_06_425584 155 1 In in IN 10_1101-2021_01_06_425584 155 2 cluster cluster NN 10_1101-2021_01_06_425584 155 3 3 3 CD 10_1101-2021_01_06_425584 155 4 , , , 10_1101-2021_01_06_425584 155 5 various various JJ 10_1101-2021_01_06_425584 155 6 301 301 CD 10_1101-2021_01_06_425584 155 7 phenylalanine phenylalanine NN 10_1101-2021_01_06_425584 155 8 - - HYPH 10_1101-2021_01_06_425584 155 9 based base VBN 10_1101-2021_01_06_425584 155 10 metabolites metabolite NNS 10_1101-2021_01_06_425584 155 11 were be VBD 10_1101-2021_01_06_425584 155 12 putatively putatively RB 10_1101-2021_01_06_425584 155 13 annotated annotate VBN 10_1101-2021_01_06_425584 155 14 aided aid VBN 10_1101-2021_01_06_425584 155 15 by by IN 10_1101-2021_01_06_425584 155 16 MS2LDA ms2lda NN 10_1101-2021_01_06_425584 155 17 substructure substructure VBP 10_1101-2021_01_06_425584 155 18 302 302 CD 10_1101-2021_01_06_425584 155 19 recognition recognition NN 10_1101-2021_01_06_425584 155 20 ( ( -LRB- 10_1101-2021_01_06_425584 155 21 Figure figure NN 10_1101-2021_01_06_425584 155 22 4C 4c NN 10_1101-2021_01_06_425584 155 23 and and CC 10_1101-2021_01_06_425584 155 24 4D 4d NN 10_1101-2021_01_06_425584 155 25 ) ) -RRB- 10_1101-2021_01_06_425584 155 26 . . . 10_1101-2021_01_06_425584 156 1 Within within IN 10_1101-2021_01_06_425584 156 2 this this DT 10_1101-2021_01_06_425584 156 3 cluster cluster NN 10_1101-2021_01_06_425584 156 4 , , , 10_1101-2021_01_06_425584 156 5 glutamyl glutamyl NNP 10_1101-2021_01_06_425584 156 6 - - HYPH 10_1101-2021_01_06_425584 156 7 phenylalanine phenylalanine NNP 10_1101-2021_01_06_425584 156 8 ( ( -LRB- 10_1101-2021_01_06_425584 156 9 annotated annotate VBN 10_1101-2021_01_06_425584 156 10 at at IN 10_1101-2021_01_06_425584 156 11 level level NN 10_1101-2021_01_06_425584 156 12 2 2 CD 10_1101-2021_01_06_425584 156 13 , , , 10_1101-2021_01_06_425584 156 14 303 303 CD 10_1101-2021_01_06_425584 156 15 MSI MSI NNP 10_1101-2021_01_06_425584 156 16 ) ) -RRB- 10_1101-2021_01_06_425584 156 17 and and CC 10_1101-2021_01_06_425584 156 18 the the DT 10_1101-2021_01_06_425584 156 19 precursor precursor NN 10_1101-2021_01_06_425584 156 20 ions ion NNS 10_1101-2021_01_06_425584 156 21 at at IN 10_1101-2021_01_06_425584 156 22 m m NNP 10_1101-2021_01_06_425584 156 23 / / SYM 10_1101-2021_01_06_425584 156 24 z z NNP 10_1101-2021_01_06_425584 156 25 297.1802 297.1802 NN 10_1101-2021_01_06_425584 156 26 and and CC 10_1101-2021_01_06_425584 156 27 487.1548 487.1548 NN 10_1101-2021_01_06_425584 156 28 presented present VBD 10_1101-2021_01_06_425584 156 29 with with IN 10_1101-2021_01_06_425584 156 30 increased increase VBN 10_1101-2021_01_06_425584 156 31 abundance abundance NN 10_1101-2021_01_06_425584 156 32 304 304 CD 10_1101-2021_01_06_425584 156 33 in in IN 10_1101-2021_01_06_425584 156 34 the the DT 10_1101-2021_01_06_425584 156 35 experimental experimental NNP 10_1101-2021_01_06_425584 156 36 vs. vs. FW 10_1101-2021_01_06_425584 156 37 control control NNP 10_1101-2021_01_06_425584 156 38 group group NNP 10_1101-2021_01_06_425584 156 39 . . . 10_1101-2021_01_06_425584 157 1 On on IN 10_1101-2021_01_06_425584 157 2 the the DT 10_1101-2021_01_06_425584 157 3 other other JJ 10_1101-2021_01_06_425584 157 4 hand hand NN 10_1101-2021_01_06_425584 157 5 , , , 10_1101-2021_01_06_425584 157 6 various various JJ 10_1101-2021_01_06_425584 157 7 aminoacids aminoacid NNS 10_1101-2021_01_06_425584 157 8 were be VBD 10_1101-2021_01_06_425584 157 9 annotated annotate VBN 10_1101-2021_01_06_425584 157 10 305 305 CD 10_1101-2021_01_06_425584 157 11 ( ( -LRB- 10_1101-2021_01_06_425584 157 12 level level NN 10_1101-2021_01_06_425584 157 13 2 2 CD 10_1101-2021_01_06_425584 157 14 , , , 10_1101-2021_01_06_425584 157 15 MSI MSI NNP 10_1101-2021_01_06_425584 157 16 ) ) -RRB- 10_1101-2021_01_06_425584 157 17 by by IN 10_1101-2021_01_06_425584 157 18 GNPS gnps NN 10_1101-2021_01_06_425584 157 19 spectral spectral NN 10_1101-2021_01_06_425584 157 20 matching matching NN 10_1101-2021_01_06_425584 157 21 and and CC 10_1101-2021_01_06_425584 157 22 manual manual JJ 10_1101-2021_01_06_425584 157 23 inspection inspection NN 10_1101-2021_01_06_425584 157 24 of of IN 10_1101-2021_01_06_425584 157 25 data datum NNS 10_1101-2021_01_06_425584 157 26 ( ( -LRB- 10_1101-2021_01_06_425584 157 27 Table table NN 10_1101-2021_01_06_425584 157 28 S2 S2 NNP 10_1101-2021_01_06_425584 157 29 ) ) -RRB- 10_1101-2021_01_06_425584 157 30 . . . 10_1101-2021_01_06_425584 158 1 Threonine Threonine NNP 10_1101-2021_01_06_425584 158 2 , , , 10_1101-2021_01_06_425584 158 3 306 306 CD 10_1101-2021_01_06_425584 158 4 valine valine NN 10_1101-2021_01_06_425584 158 5 , , , 10_1101-2021_01_06_425584 158 6 proline proline NN 10_1101-2021_01_06_425584 158 7 , , , 10_1101-2021_01_06_425584 158 8 leucine leucine NNP 10_1101-2021_01_06_425584 158 9 , , , 10_1101-2021_01_06_425584 158 10 serine serine NNP 10_1101-2021_01_06_425584 158 11 , , , 10_1101-2021_01_06_425584 158 12 glutamic glutamic JJ 10_1101-2021_01_06_425584 158 13 acid acid NN 10_1101-2021_01_06_425584 158 14 , , , 10_1101-2021_01_06_425584 158 15 methionine methionine NNP 10_1101-2021_01_06_425584 158 16 , , , 10_1101-2021_01_06_425584 158 17 and and CC 10_1101-2021_01_06_425584 158 18 tyrosine tyrosine NN 10_1101-2021_01_06_425584 158 19 presented present VBN 10_1101-2021_01_06_425584 158 20 increased increase VBD 10_1101-2021_01_06_425584 158 21 307 307 CD 10_1101-2021_01_06_425584 158 22 abundance abundance NN 10_1101-2021_01_06_425584 158 23 ( ( -LRB- 10_1101-2021_01_06_425584 158 24 fold fold VB 10_1101-2021_01_06_425584 158 25 change change NN 10_1101-2021_01_06_425584 158 26 range range NNP 10_1101-2021_01_06_425584 158 27 1.3 1.3 CD 10_1101-2021_01_06_425584 158 28 - - SYM 10_1101-2021_01_06_425584 158 29 1.7 1.7 CD 10_1101-2021_01_06_425584 158 30 , , , 10_1101-2021_01_06_425584 158 31 p<0.05 p<0.05 JJ 10_1101-2021_01_06_425584 158 32 ) ) -RRB- 10_1101-2021_01_06_425584 158 33 in in IN 10_1101-2021_01_06_425584 158 34 the the DT 10_1101-2021_01_06_425584 158 35 experimental experimental NNP 10_1101-2021_01_06_425584 158 36 vs. vs. FW 10_1101-2021_01_06_425584 158 37 control control NNP 10_1101-2021_01_06_425584 158 38 group group NNP 10_1101-2021_01_06_425584 158 39 . . . 10_1101-2021_01_06_425584 159 1 Particularly particularly RB 10_1101-2021_01_06_425584 159 2 , , , 10_1101-2021_01_06_425584 159 3 308 308 CD 10_1101-2021_01_06_425584 159 4 metabolites metabolite NNS 10_1101-2021_01_06_425584 159 5 linked link VBN 10_1101-2021_01_06_425584 159 6 to to IN 10_1101-2021_01_06_425584 159 7 the the DT 10_1101-2021_01_06_425584 159 8 catabolism catabolism NN 10_1101-2021_01_06_425584 159 9 of of IN 10_1101-2021_01_06_425584 159 10 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 159 11 via via IN 10_1101-2021_01_06_425584 159 12 the the DT 10_1101-2021_01_06_425584 159 13 serotonin serotonin NNP 10_1101-2021_01_06_425584 159 14 and and CC 10_1101-2021_01_06_425584 159 15 kynurenine kynurenine NNP 10_1101-2021_01_06_425584 159 16 pathway pathway NNP 10_1101-2021_01_06_425584 159 17 ( ( -LRB- 10_1101-2021_01_06_425584 159 18 39 39 CD 10_1101-2021_01_06_425584 159 19 ) ) -RRB- 10_1101-2021_01_06_425584 159 20 309 309 CD 10_1101-2021_01_06_425584 159 21 were be VBD 10_1101-2021_01_06_425584 159 22 annotated annotate VBN 10_1101-2021_01_06_425584 159 23 ( ( -LRB- 10_1101-2021_01_06_425584 159 24 level level NN 10_1101-2021_01_06_425584 159 25 2 2 CD 10_1101-2021_01_06_425584 159 26 , , , 10_1101-2021_01_06_425584 159 27 MSI MSI NNP 10_1101-2021_01_06_425584 159 28 ) ) -RRB- 10_1101-2021_01_06_425584 159 29 , , , 10_1101-2021_01_06_425584 159 30 including include VBG 10_1101-2021_01_06_425584 159 31 melatonin melatonin NNP 10_1101-2021_01_06_425584 159 32 , , , 10_1101-2021_01_06_425584 159 33 acetyl acetyl NNP 10_1101-2021_01_06_425584 159 34 serotonin serotonin NN 10_1101-2021_01_06_425584 159 35 , , , 10_1101-2021_01_06_425584 159 36 and and CC 10_1101-2021_01_06_425584 159 37 kynurenine kynurenine NNP 10_1101-2021_01_06_425584 159 38 ( ( -LRB- 10_1101-2021_01_06_425584 159 39 Table table NN 10_1101-2021_01_06_425584 159 40 S1 S1 NNP 10_1101-2021_01_06_425584 159 41 ) ) -RRB- 10_1101-2021_01_06_425584 159 42 . . . 10_1101-2021_01_06_425584 160 1 310 310 CD 10_1101-2021_01_06_425584 160 2 However however RB 10_1101-2021_01_06_425584 160 3 , , , 10_1101-2021_01_06_425584 160 4 only only RB 10_1101-2021_01_06_425584 160 5 kynurenine kynurenine NNP 10_1101-2021_01_06_425584 160 6 was be VBD 10_1101-2021_01_06_425584 160 7 significantly significantly RB 10_1101-2021_01_06_425584 160 8 elevated elevate VBN 10_1101-2021_01_06_425584 160 9 in in IN 10_1101-2021_01_06_425584 160 10 the the DT 10_1101-2021_01_06_425584 160 11 experimental experimental JJ 10_1101-2021_01_06_425584 160 12 group group NN 10_1101-2021_01_06_425584 160 13 . . . 10_1101-2021_01_06_425584 161 1 The the DT 10_1101-2021_01_06_425584 161 2 full full JJ 10_1101-2021_01_06_425584 161 3 list list NN 10_1101-2021_01_06_425584 161 4 of of IN 10_1101-2021_01_06_425584 161 5 311 311 CD 10_1101-2021_01_06_425584 161 6 annotated annotate VBN 10_1101-2021_01_06_425584 161 7 metabolites metabolite NNS 10_1101-2021_01_06_425584 161 8 , , , 10_1101-2021_01_06_425584 161 9 differential differential NN 10_1101-2021_01_06_425584 161 10 abundances abundance NNS 10_1101-2021_01_06_425584 161 11 and and CC 10_1101-2021_01_06_425584 161 12 another another DT 10_1101-2021_01_06_425584 161 13 relevant relevant JJ 10_1101-2021_01_06_425584 161 14 feature feature NN 10_1101-2021_01_06_425584 161 15 information information NN 10_1101-2021_01_06_425584 161 16 is be VBZ 10_1101-2021_01_06_425584 161 17 shown show VBN 10_1101-2021_01_06_425584 161 18 312 312 CD 10_1101-2021_01_06_425584 161 19 in in IN 10_1101-2021_01_06_425584 161 20 Table Table NNP 10_1101-2021_01_06_425584 161 21 S2 S2 NNP 10_1101-2021_01_06_425584 161 22 . . . 10_1101-2021_01_06_425584 162 1 313 313 CD 10_1101-2021_01_06_425584 162 2 314 314 CD 10_1101-2021_01_06_425584 162 3 Peptidomics Peptidomics NNP 10_1101-2021_01_06_425584 162 4 315 315 CD 10_1101-2021_01_06_425584 162 5 Experimental Experimental NNP 10_1101-2021_01_06_425584 162 6 and and CC 10_1101-2021_01_06_425584 162 7 control control NN 10_1101-2021_01_06_425584 162 8 datasets dataset NNS 10_1101-2021_01_06_425584 162 9 were be VBD 10_1101-2021_01_06_425584 162 10 analyzed analyze VBN 10_1101-2021_01_06_425584 162 11 separately separately RB 10_1101-2021_01_06_425584 162 12 to to TO 10_1101-2021_01_06_425584 162 13 identify identify VB 10_1101-2021_01_06_425584 162 14 the the DT 10_1101-2021_01_06_425584 162 15 peptides peptide NNS 10_1101-2021_01_06_425584 162 16 and and CC 10_1101-2021_01_06_425584 162 17 their -PRON- PRP$ 10_1101-2021_01_06_425584 162 18 316 316 CD 10_1101-2021_01_06_425584 162 19 biological biological JJ 10_1101-2021_01_06_425584 162 20 modifications modification NNS 10_1101-2021_01_06_425584 162 21 . . . 10_1101-2021_01_06_425584 163 1 The the DT 10_1101-2021_01_06_425584 163 2 complete complete JJ 10_1101-2021_01_06_425584 163 3 list list NN 10_1101-2021_01_06_425584 163 4 of of IN 10_1101-2021_01_06_425584 163 5 peptides peptide NNS 10_1101-2021_01_06_425584 163 6 identified identify VBN 10_1101-2021_01_06_425584 163 7 by by IN 10_1101-2021_01_06_425584 163 8 ProteinPilot ProteinPilot NNP 10_1101-2021_01_06_425584 163 9 between between IN 10_1101-2021_01_06_425584 163 10 the the DT 10_1101-2021_01_06_425584 163 11 317 317 CD 10_1101-2021_01_06_425584 163 12 experimental experimental JJ 10_1101-2021_01_06_425584 163 13 and and CC 10_1101-2021_01_06_425584 163 14 control control NN 10_1101-2021_01_06_425584 163 15 groups group NNS 10_1101-2021_01_06_425584 163 16 are be VBP 10_1101-2021_01_06_425584 163 17 described describe VBN 10_1101-2021_01_06_425584 163 18 in in IN 10_1101-2021_01_06_425584 163 19 Table Table NNP 10_1101-2021_01_06_425584 163 20 S3 S3 NNP 10_1101-2021_01_06_425584 163 21 . . . 10_1101-2021_01_06_425584 164 1 Proline proline JJ 10_1101-2021_01_06_425584 164 2 oxidation oxidation NN 10_1101-2021_01_06_425584 164 3 was be VBD 10_1101-2021_01_06_425584 164 4 the the DT 10_1101-2021_01_06_425584 164 5 most most RBS 10_1101-2021_01_06_425584 164 6 318 318 CD 10_1101-2021_01_06_425584 164 7 frequent frequent JJ 10_1101-2021_01_06_425584 164 8 biological biological JJ 10_1101-2021_01_06_425584 164 9 modification modification NN 10_1101-2021_01_06_425584 164 10 detected detect VBN 10_1101-2021_01_06_425584 164 11 in in IN 10_1101-2021_01_06_425584 164 12 the the DT 10_1101-2021_01_06_425584 164 13 experimental experimental JJ 10_1101-2021_01_06_425584 164 14 group group NN 10_1101-2021_01_06_425584 164 15 datasets dataset NNS 10_1101-2021_01_06_425584 164 16 . . . 10_1101-2021_01_06_425584 165 1 We -PRON- PRP 10_1101-2021_01_06_425584 165 2 identified identify VBD 10_1101-2021_01_06_425584 165 3 8 8 CD 10_1101-2021_01_06_425584 165 4 and and CC 10_1101-2021_01_06_425584 165 5 319 319 CD 10_1101-2021_01_06_425584 165 6 12 12 CD 10_1101-2021_01_06_425584 165 7 peptides peptide NNS 10_1101-2021_01_06_425584 165 8 with with IN 10_1101-2021_01_06_425584 165 9 a a DT 10_1101-2021_01_06_425584 165 10 confidence confidence NN 10_1101-2021_01_06_425584 165 11 of of IN 10_1101-2021_01_06_425584 165 12 > > XX 10_1101-2021_01_06_425584 165 13 90 90 CD 10_1101-2021_01_06_425584 165 14 % % NN 10_1101-2021_01_06_425584 165 15 in in IN 10_1101-2021_01_06_425584 165 16 the the DT 10_1101-2021_01_06_425584 165 17 control control NN 10_1101-2021_01_06_425584 165 18 and and CC 10_1101-2021_01_06_425584 165 19 experimental experimental JJ 10_1101-2021_01_06_425584 165 20 group group NN 10_1101-2021_01_06_425584 165 21 , , , 10_1101-2021_01_06_425584 165 22 respectively respectively RB 10_1101-2021_01_06_425584 165 23 . . . 10_1101-2021_01_06_425584 166 1 320 320 CD 10_1101-2021_01_06_425584 166 2 Differential differential JJ 10_1101-2021_01_06_425584 166 3 abundance abundance NN 10_1101-2021_01_06_425584 166 4 of of IN 10_1101-2021_01_06_425584 166 5 2 2 CD 10_1101-2021_01_06_425584 166 6 proline proline JJ 10_1101-2021_01_06_425584 166 7 - - HYPH 10_1101-2021_01_06_425584 166 8 rich rich JJ 10_1101-2021_01_06_425584 166 9 peptides peptide NNS 10_1101-2021_01_06_425584 166 10 was be VBD 10_1101-2021_01_06_425584 166 11 observed observe VBN 10_1101-2021_01_06_425584 166 12 in in IN 10_1101-2021_01_06_425584 166 13 the the DT 10_1101-2021_01_06_425584 166 14 experimental experimental JJ 10_1101-2021_01_06_425584 166 15 group group NN 10_1101-2021_01_06_425584 166 16 321 321 CD 10_1101-2021_01_06_425584 166 17 .CC .CC , 10_1101-2021_01_06_425584 166 18 - - HYPH 10_1101-2021_01_06_425584 166 19 BY by IN 10_1101-2021_01_06_425584 166 20 - - HYPH 10_1101-2021_01_06_425584 166 21 NC NC NNP 10_1101-2021_01_06_425584 166 22 - - HYPH 10_1101-2021_01_06_425584 166 23 ND ND NNP 10_1101-2021_01_06_425584 166 24 4.0 4.0 CD 10_1101-2021_01_06_425584 166 25 International International NNP 10_1101-2021_01_06_425584 166 26 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 166 27 under under IN 10_1101-2021_01_06_425584 166 28 a a DT 10_1101-2021_01_06_425584 166 29 ( ( -LRB- 10_1101-2021_01_06_425584 166 30 which which WDT 10_1101-2021_01_06_425584 166 31 was be VBD 10_1101-2021_01_06_425584 166 32 not not RB 10_1101-2021_01_06_425584 166 33 certified certify VBN 10_1101-2021_01_06_425584 166 34 by by IN 10_1101-2021_01_06_425584 166 35 peer peer NN 10_1101-2021_01_06_425584 166 36 review review NN 10_1101-2021_01_06_425584 166 37 ) ) -RRB- 10_1101-2021_01_06_425584 166 38 is be VBZ 10_1101-2021_01_06_425584 166 39 the the DT 10_1101-2021_01_06_425584 166 40 author author NN 10_1101-2021_01_06_425584 166 41 / / SYM 10_1101-2021_01_06_425584 166 42 funder funder NN 10_1101-2021_01_06_425584 166 43 , , , 10_1101-2021_01_06_425584 166 44 who who WP 10_1101-2021_01_06_425584 166 45 has have VBZ 10_1101-2021_01_06_425584 166 46 granted grant VBN 10_1101-2021_01_06_425584 166 47 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 166 48 a a DT 10_1101-2021_01_06_425584 166 49 license license NN 10_1101-2021_01_06_425584 166 50 to to TO 10_1101-2021_01_06_425584 166 51 display display VB 10_1101-2021_01_06_425584 166 52 the the DT 10_1101-2021_01_06_425584 166 53 preprint preprint NN 10_1101-2021_01_06_425584 166 54 in in IN 10_1101-2021_01_06_425584 166 55 perpetuity perpetuity NN 10_1101-2021_01_06_425584 166 56 . . . 10_1101-2021_01_06_425584 167 1 It -PRON- PRP 10_1101-2021_01_06_425584 167 2 is be VBZ 10_1101-2021_01_06_425584 167 3 made make VBN 10_1101-2021_01_06_425584 167 4 The the DT 10_1101-2021_01_06_425584 167 5 copyright copyright NN 10_1101-2021_01_06_425584 167 6 holder holder NN 10_1101-2021_01_06_425584 167 7 for for IN 10_1101-2021_01_06_425584 167 8 this this DT 10_1101-2021_01_06_425584 167 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 167 10 version version NN 10_1101-2021_01_06_425584 167 11 posted post VBD 10_1101-2021_01_06_425584 167 12 January January NNP 10_1101-2021_01_06_425584 167 13 8 8 CD 10_1101-2021_01_06_425584 167 14 , , , 10_1101-2021_01_06_425584 167 15 2021 2021 CD 10_1101-2021_01_06_425584 167 16 . . . 10_1101-2021_01_06_425584 167 17 ; ; : 10_1101-2021_01_06_425584 167 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 167 19 : : : 10_1101-2021_01_06_425584 167 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 167 21 preprint preprint NN 10_1101-2021_01_06_425584 167 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 167 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 167 24 11 11 CD 10_1101-2021_01_06_425584 167 25 compared compare VBN 10_1101-2021_01_06_425584 167 26 to to IN 10_1101-2021_01_06_425584 167 27 the the DT 10_1101-2021_01_06_425584 167 28 control control NN 10_1101-2021_01_06_425584 167 29 group group NN 10_1101-2021_01_06_425584 167 30 . . . 10_1101-2021_01_06_425584 168 1 An an DT 10_1101-2021_01_06_425584 168 2 additional additional JJ 10_1101-2021_01_06_425584 168 3 tripeptide tripeptide NN 10_1101-2021_01_06_425584 168 4 was be VBD 10_1101-2021_01_06_425584 168 5 manually manually RB 10_1101-2021_01_06_425584 168 6 annotated annotate VBN 10_1101-2021_01_06_425584 168 7 with with IN 10_1101-2021_01_06_425584 168 8 a a DT 10_1101-2021_01_06_425584 168 9 LPP LPP NNP 10_1101-2021_01_06_425584 168 10 322 322 CD 10_1101-2021_01_06_425584 168 11 sequence sequence NN 10_1101-2021_01_06_425584 168 12 ( ( -LRB- 10_1101-2021_01_06_425584 168 13 Table Table NNP 10_1101-2021_01_06_425584 168 14 S4 S4 NNP 10_1101-2021_01_06_425584 168 15 ) ) -RRB- 10_1101-2021_01_06_425584 168 16 . . . 10_1101-2021_01_06_425584 169 1 323 323 CD 10_1101-2021_01_06_425584 169 2 324 324 CD 10_1101-2021_01_06_425584 169 3 Proteomics Proteomics NNP 10_1101-2021_01_06_425584 169 4 325 325 CD 10_1101-2021_01_06_425584 169 5 The the DT 10_1101-2021_01_06_425584 169 6 re re NN 10_1101-2021_01_06_425584 169 7 - - NN 10_1101-2021_01_06_425584 169 8 analysis analysis NN 10_1101-2021_01_06_425584 169 9 of of IN 10_1101-2021_01_06_425584 169 10 the the DT 10_1101-2021_01_06_425584 169 11 SWATH SWATH NNP 10_1101-2021_01_06_425584 169 12 data datum NNS 10_1101-2021_01_06_425584 169 13 ( ( -LRB- 10_1101-2021_01_06_425584 169 14 PXD013643 PXD013643 NNP 10_1101-2021_01_06_425584 169 15 dataset dataset NNP 10_1101-2021_01_06_425584 169 16 ) ) -RRB- 10_1101-2021_01_06_425584 169 17 facilitated facilitate VBD 10_1101-2021_01_06_425584 169 18 the the DT 10_1101-2021_01_06_425584 169 19 identification identification NN 10_1101-2021_01_06_425584 169 20 of of IN 10_1101-2021_01_06_425584 169 21 952 952 CD 10_1101-2021_01_06_425584 169 22 326 326 CD 10_1101-2021_01_06_425584 169 23 quantifiable quantifiable JJ 10_1101-2021_01_06_425584 169 24 proteins protein NNS 10_1101-2021_01_06_425584 169 25 ( ( -LRB- 10_1101-2021_01_06_425584 169 26 717 717 CD 10_1101-2021_01_06_425584 169 27 proteins protein NNS 10_1101-2021_01_06_425584 169 28 with with IN 10_1101-2021_01_06_425584 169 29 at at RB 10_1101-2021_01_06_425584 169 30 least least RBS 10_1101-2021_01_06_425584 169 31 2 2 CD 10_1101-2021_01_06_425584 169 32 unique unique JJ 10_1101-2021_01_06_425584 169 33 peptides peptide NNS 10_1101-2021_01_06_425584 169 34 , , , 10_1101-2021_01_06_425584 169 35 1 1 CD 10_1101-2021_01_06_425584 169 36 % % NN 10_1101-2021_01_06_425584 169 37 false false JJ 10_1101-2021_01_06_425584 169 38 discovery discovery NN 10_1101-2021_01_06_425584 169 39 rate rate NN 10_1101-2021_01_06_425584 169 40 ) ) -RRB- 10_1101-2021_01_06_425584 169 41 and and CC 10_1101-2021_01_06_425584 169 42 327 327 CD 10_1101-2021_01_06_425584 169 43 no no DT 10_1101-2021_01_06_425584 169 44 missing miss VBG 10_1101-2021_01_06_425584 169 45 values value NNS 10_1101-2021_01_06_425584 169 46 among among IN 10_1101-2021_01_06_425584 169 47 technical technical JJ 10_1101-2021_01_06_425584 169 48 and and CC 10_1101-2021_01_06_425584 169 49 biological biological JJ 10_1101-2021_01_06_425584 169 50 replicates replicate NNS 10_1101-2021_01_06_425584 169 51 ( ( -LRB- 10_1101-2021_01_06_425584 169 52 Table table NN 10_1101-2021_01_06_425584 169 53 S5 s5 NN 10_1101-2021_01_06_425584 169 54 ) ) -RRB- 10_1101-2021_01_06_425584 169 55 . . . 10_1101-2021_01_06_425584 170 1 Sample sample NN 10_1101-2021_01_06_425584 170 2 datasets dataset NNS 10_1101-2021_01_06_425584 170 3 were be VBD 10_1101-2021_01_06_425584 170 4 328 328 CD 10_1101-2021_01_06_425584 170 5 normalized normalized JJ 10_1101-2021_01_06_425584 170 6 using use VBG 10_1101-2021_01_06_425584 170 7 8 8 CD 10_1101-2021_01_06_425584 170 8 different different JJ 10_1101-2021_01_06_425584 170 9 methods method NNS 10_1101-2021_01_06_425584 170 10 to to TO 10_1101-2021_01_06_425584 170 11 select select VB 10_1101-2021_01_06_425584 170 12 the the DT 10_1101-2021_01_06_425584 170 13 most most RBS 10_1101-2021_01_06_425584 170 14 appropriate appropriate JJ 10_1101-2021_01_06_425584 170 15 based base VBN 10_1101-2021_01_06_425584 170 16 on on IN 10_1101-2021_01_06_425584 170 17 quantitative quantitative JJ 10_1101-2021_01_06_425584 170 18 and and CC 10_1101-2021_01_06_425584 170 19 329 329 CD 10_1101-2021_01_06_425584 170 20 qualitative qualitative JJ 10_1101-2021_01_06_425584 170 21 parameters parameter NNS 10_1101-2021_01_06_425584 170 22 on on IN 10_1101-2021_01_06_425584 170 23 our -PRON- PRP$ 10_1101-2021_01_06_425584 170 24 dataset dataset NN 10_1101-2021_01_06_425584 170 25 . . . 10_1101-2021_01_06_425584 171 1 Quantile Quantile NNP 10_1101-2021_01_06_425584 171 2 normalization normalization NN 10_1101-2021_01_06_425584 171 3 produced produce VBD 10_1101-2021_01_06_425584 171 4 a a DT 10_1101-2021_01_06_425584 171 5 better well JJR 10_1101-2021_01_06_425584 171 6 qualitative qualitative JJ 10_1101-2021_01_06_425584 171 7 and and CC 10_1101-2021_01_06_425584 171 8 330 330 CD 10_1101-2021_01_06_425584 171 9 quantitative quantitative JJ 10_1101-2021_01_06_425584 171 10 profile profile NN 10_1101-2021_01_06_425584 171 11 and and CC 10_1101-2021_01_06_425584 171 12 was be VBD 10_1101-2021_01_06_425584 171 13 selected select VBN 10_1101-2021_01_06_425584 171 14 to to TO 10_1101-2021_01_06_425584 171 15 further further RB 10_1101-2021_01_06_425584 171 16 process process VB 10_1101-2021_01_06_425584 171 17 our -PRON- PRP$ 10_1101-2021_01_06_425584 171 18 data datum NNS 10_1101-2021_01_06_425584 171 19 ( ( -LRB- 10_1101-2021_01_06_425584 171 20 Figure figure NN 10_1101-2021_01_06_425584 171 21 S1 s1 NN 10_1101-2021_01_06_425584 171 22 ) ) -RRB- 10_1101-2021_01_06_425584 171 23 . . . 10_1101-2021_01_06_425584 172 1 PCA PCA NNP 10_1101-2021_01_06_425584 172 2 analysis analysis NN 10_1101-2021_01_06_425584 172 3 of of IN 10_1101-2021_01_06_425584 172 4 331 331 CD 10_1101-2021_01_06_425584 172 5 normalized normalized JJ 10_1101-2021_01_06_425584 172 6 data datum NNS 10_1101-2021_01_06_425584 172 7 denoted denote VBD 10_1101-2021_01_06_425584 172 8 a a DT 10_1101-2021_01_06_425584 172 9 clear clear JJ 10_1101-2021_01_06_425584 172 10 separation separation NN 10_1101-2021_01_06_425584 172 11 of of IN 10_1101-2021_01_06_425584 172 12 the the DT 10_1101-2021_01_06_425584 172 13 groups group NNS 10_1101-2021_01_06_425584 172 14 suggesting suggest VBG 10_1101-2021_01_06_425584 172 15 overall overall JJ 10_1101-2021_01_06_425584 172 16 differences difference NNS 10_1101-2021_01_06_425584 172 17 in in IN 10_1101-2021_01_06_425584 172 18 their -PRON- PRP$ 10_1101-2021_01_06_425584 172 19 332 332 CD 10_1101-2021_01_06_425584 172 20 proteomes proteome NNS 10_1101-2021_01_06_425584 172 21 ( ( -LRB- 10_1101-2021_01_06_425584 172 22 Figure figure NN 10_1101-2021_01_06_425584 172 23 5A 5a RB 10_1101-2021_01_06_425584 172 24 ) ) -RRB- 10_1101-2021_01_06_425584 172 25 . . . 10_1101-2021_01_06_425584 173 1 Differential differential JJ 10_1101-2021_01_06_425584 173 2 abundance abundance NN 10_1101-2021_01_06_425584 173 3 analysis analysis NN 10_1101-2021_01_06_425584 173 4 revealed reveal VBD 10_1101-2021_01_06_425584 173 5 32 32 CD 10_1101-2021_01_06_425584 173 6 and and CC 10_1101-2021_01_06_425584 173 7 33 33 CD 10_1101-2021_01_06_425584 173 8 proteins protein NNS 10_1101-2021_01_06_425584 173 9 with with IN 10_1101-2021_01_06_425584 173 10 333 333 CD 10_1101-2021_01_06_425584 173 11 increased increase VBN 10_1101-2021_01_06_425584 173 12 and and CC 10_1101-2021_01_06_425584 173 13 decreased decrease VBD 10_1101-2021_01_06_425584 173 14 abundance abundance NN 10_1101-2021_01_06_425584 173 15 in in IN 10_1101-2021_01_06_425584 173 16 the the DT 10_1101-2021_01_06_425584 173 17 experimental experimental JJ 10_1101-2021_01_06_425584 173 18 group group NN 10_1101-2021_01_06_425584 173 19 ( ( -LRB- 10_1101-2021_01_06_425584 173 20 Figure Figure NNP 10_1101-2021_01_06_425584 173 21 5B 5b NN 10_1101-2021_01_06_425584 173 22 ) ) -RRB- 10_1101-2021_01_06_425584 173 23 . . . 10_1101-2021_01_06_425584 174 1 Further further RB 10_1101-2021_01_06_425584 174 2 , , , 10_1101-2021_01_06_425584 174 3 the the DT 10_1101-2021_01_06_425584 174 4 334 334 CD 10_1101-2021_01_06_425584 174 5 heatmap heatmap NN 10_1101-2021_01_06_425584 174 6 visualization visualization NN 10_1101-2021_01_06_425584 174 7 of of IN 10_1101-2021_01_06_425584 174 8 the the DT 10_1101-2021_01_06_425584 174 9 top top JJ 10_1101-2021_01_06_425584 174 10 50-modulated 50-modulated CD 10_1101-2021_01_06_425584 174 11 proteins protein NNS 10_1101-2021_01_06_425584 174 12 exhibited exhibit VBD 10_1101-2021_01_06_425584 174 13 the the DT 10_1101-2021_01_06_425584 174 14 different different JJ 10_1101-2021_01_06_425584 174 15 distribution distribution NN 10_1101-2021_01_06_425584 174 16 patterns pattern VBZ 10_1101-2021_01_06_425584 174 17 335 335 CD 10_1101-2021_01_06_425584 174 18 among among IN 10_1101-2021_01_06_425584 174 19 the the DT 10_1101-2021_01_06_425584 174 20 experimental experimental JJ 10_1101-2021_01_06_425584 174 21 and and CC 10_1101-2021_01_06_425584 174 22 control control NN 10_1101-2021_01_06_425584 174 23 groups group NNS 10_1101-2021_01_06_425584 174 24 ( ( -LRB- 10_1101-2021_01_06_425584 174 25 Figure figure NN 10_1101-2021_01_06_425584 174 26 5C 5c NN 10_1101-2021_01_06_425584 174 27 ) ) -RRB- 10_1101-2021_01_06_425584 174 28 . . . 10_1101-2021_01_06_425584 175 1 To to TO 10_1101-2021_01_06_425584 175 2 obtain obtain VB 10_1101-2021_01_06_425584 175 3 a a DT 10_1101-2021_01_06_425584 175 4 molecular molecular JJ 10_1101-2021_01_06_425584 175 5 insight insight NN 10_1101-2021_01_06_425584 175 6 we -PRON- PRP 10_1101-2021_01_06_425584 175 7 336 336 CD 10_1101-2021_01_06_425584 175 8 performed perform VBD 10_1101-2021_01_06_425584 175 9 a a DT 10_1101-2021_01_06_425584 175 10 functional functional JJ 10_1101-2021_01_06_425584 175 11 enrichment enrichment NN 10_1101-2021_01_06_425584 175 12 analysis analysis NN 10_1101-2021_01_06_425584 175 13 using use VBG 10_1101-2021_01_06_425584 175 14 a a DT 10_1101-2021_01_06_425584 175 15 network network NN 10_1101-2021_01_06_425584 175 16 - - HYPH 10_1101-2021_01_06_425584 175 17 based base VBN 10_1101-2021_01_06_425584 175 18 approach approach NN 10_1101-2021_01_06_425584 175 19 . . . 10_1101-2021_01_06_425584 176 1 First first RB 10_1101-2021_01_06_425584 176 2 , , , 10_1101-2021_01_06_425584 176 3 we -PRON- PRP 10_1101-2021_01_06_425584 176 4 created create VBD 10_1101-2021_01_06_425584 176 5 a a DT 10_1101-2021_01_06_425584 176 6 337 337 CD 10_1101-2021_01_06_425584 176 7 composite composite JJ 10_1101-2021_01_06_425584 176 8 network network NN 10_1101-2021_01_06_425584 176 9 comprising comprise VBG 10_1101-2021_01_06_425584 176 10 PPI PPI NNP 10_1101-2021_01_06_425584 176 11 between between IN 10_1101-2021_01_06_425584 176 12 the the DT 10_1101-2021_01_06_425584 176 13 modulated modulate VBN 10_1101-2021_01_06_425584 176 14 proteins protein NNS 10_1101-2021_01_06_425584 176 15 by by IN 10_1101-2021_01_06_425584 176 16 simulated simulated JJ 10_1101-2021_01_06_425584 176 17 diabetes diabete NNS 10_1101-2021_01_06_425584 176 18 ( ( -LRB- 10_1101-2021_01_06_425584 176 19 seed seed NN 10_1101-2021_01_06_425584 176 20 338 338 CD 10_1101-2021_01_06_425584 176 21 proteins protein NNS 10_1101-2021_01_06_425584 176 22 ) ) -RRB- 10_1101-2021_01_06_425584 176 23 and and CC 10_1101-2021_01_06_425584 176 24 their -PRON- PRP$ 10_1101-2021_01_06_425584 176 25 immediate immediate JJ 10_1101-2021_01_06_425584 176 26 interacting interact VBG 10_1101-2021_01_06_425584 176 27 partners partner NNS 10_1101-2021_01_06_425584 176 28 ( ( -LRB- 10_1101-2021_01_06_425584 176 29 highest high JJS 10_1101-2021_01_06_425584 176 30 confidence confidence NN 10_1101-2021_01_06_425584 176 31 > > NN 10_1101-2021_01_06_425584 176 32 0.9 0.9 CD 10_1101-2021_01_06_425584 176 33 ) ) -RRB- 10_1101-2021_01_06_425584 176 34 retrieved retrieve VBN 10_1101-2021_01_06_425584 176 35 from from IN 10_1101-2021_01_06_425584 176 36 339 339 CD 10_1101-2021_01_06_425584 176 37 STRING STRING NNP 10_1101-2021_01_06_425584 176 38 Database Database NNP 10_1101-2021_01_06_425584 176 39 ( ( -LRB- 10_1101-2021_01_06_425584 176 40 incorporated incorporate VBN 10_1101-2021_01_06_425584 176 41 in in IN 10_1101-2021_01_06_425584 176 42 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 176 43 platform platform NN 10_1101-2021_01_06_425584 176 44 ) ) -RRB- 10_1101-2021_01_06_425584 176 45 . . . 10_1101-2021_01_06_425584 177 1 The the DT 10_1101-2021_01_06_425584 177 2 principal principal JJ 10_1101-2021_01_06_425584 177 3 network network NN 10_1101-2021_01_06_425584 177 4 using use VBG 10_1101-2021_01_06_425584 177 5 the the DT 10_1101-2021_01_06_425584 177 6 up-340 up-340 NNP 10_1101-2021_01_06_425584 177 7 modulated modulate VBN 10_1101-2021_01_06_425584 177 8 proteins protein NNS 10_1101-2021_01_06_425584 177 9 consisted consist VBD 10_1101-2021_01_06_425584 177 10 of of IN 10_1101-2021_01_06_425584 177 11 461 461 CD 10_1101-2021_01_06_425584 177 12 proteins protein NNS 10_1101-2021_01_06_425584 177 13 , , , 10_1101-2021_01_06_425584 177 14 709 709 CD 10_1101-2021_01_06_425584 177 15 edges edge NNS 10_1101-2021_01_06_425584 177 16 and and CC 10_1101-2021_01_06_425584 177 17 18 18 CD 10_1101-2021_01_06_425584 177 18 seed seed NN 10_1101-2021_01_06_425584 177 19 proteins protein NNS 10_1101-2021_01_06_425584 177 20 ( ( -LRB- 10_1101-2021_01_06_425584 177 21 nodes node NNS 10_1101-2021_01_06_425584 177 22 with with IN 10_1101-2021_01_06_425584 177 23 blue blue JJ 10_1101-2021_01_06_425584 177 24 341 341 CD 10_1101-2021_01_06_425584 177 25 shadow shadow NN 10_1101-2021_01_06_425584 177 26 ) ) -RRB- 10_1101-2021_01_06_425584 177 27 and and CC 10_1101-2021_01_06_425584 177 28 is be VBZ 10_1101-2021_01_06_425584 177 29 illustrated illustrate VBN 10_1101-2021_01_06_425584 177 30 in in IN 10_1101-2021_01_06_425584 177 31 Figure figure NN 10_1101-2021_01_06_425584 177 32 5D. 5d. NN 10_1101-2021_01_06_425584 178 1 Eight eight CD 10_1101-2021_01_06_425584 178 2 modules module NNS 10_1101-2021_01_06_425584 178 3 or or CC 10_1101-2021_01_06_425584 178 4 clusters cluster NNS 10_1101-2021_01_06_425584 178 5 were be VBD 10_1101-2021_01_06_425584 178 6 generated generate VBN 10_1101-2021_01_06_425584 178 7 , , , 10_1101-2021_01_06_425584 178 8 that that DT 10_1101-2021_01_06_425584 178 9 may may MD 10_1101-2021_01_06_425584 178 10 342 342 CD 10_1101-2021_01_06_425584 178 11 represent represent VB 10_1101-2021_01_06_425584 178 12 relevant relevant JJ 10_1101-2021_01_06_425584 178 13 complexes complex NNS 10_1101-2021_01_06_425584 178 14 or or CC 10_1101-2021_01_06_425584 178 15 functional functional JJ 10_1101-2021_01_06_425584 178 16 units unit NNS 10_1101-2021_01_06_425584 178 17 ( ( -LRB- 10_1101-2021_01_06_425584 178 18 40 40 CD 10_1101-2021_01_06_425584 178 19 ) ) -RRB- 10_1101-2021_01_06_425584 178 20 . . . 10_1101-2021_01_06_425584 179 1 The the DT 10_1101-2021_01_06_425584 179 2 5 5 CD 10_1101-2021_01_06_425584 179 3 most most RBS 10_1101-2021_01_06_425584 179 4 significant significant JJ 10_1101-2021_01_06_425584 179 5 ( ( -LRB- 10_1101-2021_01_06_425584 179 6 adjusted adjust VBN 10_1101-2021_01_06_425584 179 7 p p NN 10_1101-2021_01_06_425584 179 8 - - HYPH 10_1101-2021_01_06_425584 179 9 value value NN 10_1101-2021_01_06_425584 179 10 343 343 CD 10_1101-2021_01_06_425584 179 11 < < XX 10_1101-2021_01_06_425584 179 12 0.05 0.05 CD 10_1101-2021_01_06_425584 179 13 ) ) -RRB- 10_1101-2021_01_06_425584 179 14 REACTOME reactome NN 10_1101-2021_01_06_425584 179 15 and and CC 10_1101-2021_01_06_425584 179 16 KEGG KEGG NNP 10_1101-2021_01_06_425584 179 17 pathways pathway NNS 10_1101-2021_01_06_425584 179 18 on on IN 10_1101-2021_01_06_425584 179 19 the the DT 10_1101-2021_01_06_425584 179 20 global global JJ 10_1101-2021_01_06_425584 179 21 network network NN 10_1101-2021_01_06_425584 179 22 are be VBP 10_1101-2021_01_06_425584 179 23 shown show VBN 10_1101-2021_01_06_425584 179 24 in in IN 10_1101-2021_01_06_425584 179 25 Table table NN 10_1101-2021_01_06_425584 179 26 1 1 CD 10_1101-2021_01_06_425584 179 27 . . . 10_1101-2021_01_06_425584 180 1 Two two CD 10_1101-2021_01_06_425584 180 2 344 344 CD 10_1101-2021_01_06_425584 180 3 modules module NNS 10_1101-2021_01_06_425584 180 4 contained contain VBD 10_1101-2021_01_06_425584 180 5 multiple multiple JJ 10_1101-2021_01_06_425584 180 6 seed seed NN 10_1101-2021_01_06_425584 180 7 proteins protein NNS 10_1101-2021_01_06_425584 180 8 and and CC 10_1101-2021_01_06_425584 180 9 were be VBD 10_1101-2021_01_06_425584 180 10 linked link VBN 10_1101-2021_01_06_425584 180 11 to to IN 10_1101-2021_01_06_425584 180 12 DNA DNA NNP 10_1101-2021_01_06_425584 180 13 / / SYM 10_1101-2021_01_06_425584 180 14 RNA RNA NNP 10_1101-2021_01_06_425584 180 15 and and CC 10_1101-2021_01_06_425584 180 16 protein protein NN 10_1101-2021_01_06_425584 180 17 metabolism metabolism NN 10_1101-2021_01_06_425584 180 18 345 345 CD 10_1101-2021_01_06_425584 180 19 pathways pathway NNS 10_1101-2021_01_06_425584 180 20 using use VBG 10_1101-2021_01_06_425584 180 21 the the DT 10_1101-2021_01_06_425584 180 22 WalkTrap WalkTrap NNP 10_1101-2021_01_06_425584 180 23 algorithm algorithm NN 10_1101-2021_01_06_425584 180 24 ( ( -LRB- 10_1101-2021_01_06_425584 180 25 Figure Figure NNP 10_1101-2021_01_06_425584 180 26 5D 5D VBZ 10_1101-2021_01_06_425584 180 27 ) ) -RRB- 10_1101-2021_01_06_425584 180 28 . . . 10_1101-2021_01_06_425584 181 1 On on IN 10_1101-2021_01_06_425584 181 2 the the DT 10_1101-2021_01_06_425584 181 3 other other JJ 10_1101-2021_01_06_425584 181 4 hand hand NN 10_1101-2021_01_06_425584 181 5 , , , 10_1101-2021_01_06_425584 181 6 the the DT 10_1101-2021_01_06_425584 181 7 principal principal JJ 10_1101-2021_01_06_425584 181 8 network network NN 10_1101-2021_01_06_425584 181 9 346 346 CD 10_1101-2021_01_06_425584 181 10 using use VBG 10_1101-2021_01_06_425584 181 11 the the DT 10_1101-2021_01_06_425584 181 12 down down RB 10_1101-2021_01_06_425584 181 13 - - HYPH 10_1101-2021_01_06_425584 181 14 modulated modulate VBN 10_1101-2021_01_06_425584 181 15 proteins protein NNS 10_1101-2021_01_06_425584 181 16 consisted consist VBD 10_1101-2021_01_06_425584 181 17 of of IN 10_1101-2021_01_06_425584 181 18 488 488 CD 10_1101-2021_01_06_425584 181 19 proteins protein NNS 10_1101-2021_01_06_425584 181 20 , , , 10_1101-2021_01_06_425584 181 21 513 513 CD 10_1101-2021_01_06_425584 181 22 edges edge NNS 10_1101-2021_01_06_425584 181 23 and and CC 10_1101-2021_01_06_425584 181 24 18 18 CD 10_1101-2021_01_06_425584 181 25 seed seed NN 10_1101-2021_01_06_425584 181 26 proteins protein VBZ 10_1101-2021_01_06_425584 181 27 347 347 CD 10_1101-2021_01_06_425584 181 28 identified identify VBN 10_1101-2021_01_06_425584 181 29 eleven eleven CD 10_1101-2021_01_06_425584 181 30 modules module NNS 10_1101-2021_01_06_425584 181 31 wherein wherein WRB 10_1101-2021_01_06_425584 181 32 one one CD 10_1101-2021_01_06_425584 181 33 module module NN 10_1101-2021_01_06_425584 181 34 ( ( -LRB- 10_1101-2021_01_06_425584 181 35 with with IN 10_1101-2021_01_06_425584 181 36 2 2 CD 10_1101-2021_01_06_425584 181 37 seed seed NN 10_1101-2021_01_06_425584 181 38 proteins protein NNS 10_1101-2021_01_06_425584 181 39 ) ) -RRB- 10_1101-2021_01_06_425584 181 40 indicated indicate VBD 10_1101-2021_01_06_425584 181 41 associations association NNS 10_1101-2021_01_06_425584 181 42 with with IN 10_1101-2021_01_06_425584 181 43 348 348 CD 10_1101-2021_01_06_425584 181 44 mitochondrial mitochondrial NN 10_1101-2021_01_06_425584 181 45 function function NN 10_1101-2021_01_06_425584 181 46 pathways pathway NNS 10_1101-2021_01_06_425584 181 47 ( ( -LRB- 10_1101-2021_01_06_425584 181 48 Figure figure VB 10_1101-2021_01_06_425584 181 49 5E 5e NN 10_1101-2021_01_06_425584 181 50 ) ) -RRB- 10_1101-2021_01_06_425584 181 51 . . . 10_1101-2021_01_06_425584 182 1 349 349 CD 10_1101-2021_01_06_425584 182 2 350 350 CD 10_1101-2021_01_06_425584 182 3 Integration Integration NNP 10_1101-2021_01_06_425584 182 4 of of IN 10_1101-2021_01_06_425584 182 5 Metabolomics Metabolomics NNPS 10_1101-2021_01_06_425584 182 6 and and CC 10_1101-2021_01_06_425584 182 7 Proteomics Proteomics NNP 10_1101-2021_01_06_425584 182 8 351 351 CD 10_1101-2021_01_06_425584 182 9 The the DT 10_1101-2021_01_06_425584 182 10 signaling signal VBG 10_1101-2021_01_06_425584 182 11 pathways pathway NNS 10_1101-2021_01_06_425584 182 12 perturbed perturb VBN 10_1101-2021_01_06_425584 182 13 by by IN 10_1101-2021_01_06_425584 182 14 simulated simulated JJ 10_1101-2021_01_06_425584 182 15 diabetes diabete NNS 10_1101-2021_01_06_425584 182 16 were be VBD 10_1101-2021_01_06_425584 182 17 identified identify VBN 10_1101-2021_01_06_425584 182 18 by by IN 10_1101-2021_01_06_425584 182 19 a a DT 10_1101-2021_01_06_425584 182 20 composite composite JJ 10_1101-2021_01_06_425584 182 21 network network NN 10_1101-2021_01_06_425584 182 22 352 352 CD 10_1101-2021_01_06_425584 182 23 of of IN 10_1101-2021_01_06_425584 182 24 interacting interact VBG 10_1101-2021_01_06_425584 182 25 metabolites metabolite NNS 10_1101-2021_01_06_425584 182 26 and and CC 10_1101-2021_01_06_425584 182 27 proteins protein NNS 10_1101-2021_01_06_425584 182 28 using use VBG 10_1101-2021_01_06_425584 182 29 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 182 30 built build VBN 10_1101-2021_01_06_425584 182 31 - - HYPH 10_1101-2021_01_06_425584 182 32 in in RP 10_1101-2021_01_06_425584 182 33 databases database NNS 10_1101-2021_01_06_425584 182 34 . . . 10_1101-2021_01_06_425584 183 1 Figure figure NN 10_1101-2021_01_06_425584 183 2 6 6 CD 10_1101-2021_01_06_425584 183 3 illustrates illustrate VBZ 10_1101-2021_01_06_425584 183 4 the the DT 10_1101-2021_01_06_425584 183 5 353 353 CD 10_1101-2021_01_06_425584 183 6 composite composite JJ 10_1101-2021_01_06_425584 183 7 bi bi JJ 10_1101-2021_01_06_425584 183 8 - - JJ 10_1101-2021_01_06_425584 183 9 layered layered JJ 10_1101-2021_01_06_425584 183 10 metabolite metabolite JJ 10_1101-2021_01_06_425584 183 11 - - HYPH 10_1101-2021_01_06_425584 183 12 PPI PPI NNP 10_1101-2021_01_06_425584 183 13 network network NN 10_1101-2021_01_06_425584 183 14 using use VBG 10_1101-2021_01_06_425584 183 15 the the DT 10_1101-2021_01_06_425584 183 16 up up RB 10_1101-2021_01_06_425584 183 17 - - HYPH 10_1101-2021_01_06_425584 183 18 modulated modulate VBN 10_1101-2021_01_06_425584 183 19 molecules molecule NNS 10_1101-2021_01_06_425584 183 20 ( ( -LRB- 10_1101-2021_01_06_425584 183 21 under under IN 10_1101-2021_01_06_425584 183 22 simulated simulate VBN 10_1101-2021_01_06_425584 183 23 354 354 CD 10_1101-2021_01_06_425584 183 24 diabetes diabetes NN 10_1101-2021_01_06_425584 183 25 ) ) -RRB- 10_1101-2021_01_06_425584 183 26 comprised comprise VBN 10_1101-2021_01_06_425584 183 27 of of IN 10_1101-2021_01_06_425584 183 28 9 9 CD 10_1101-2021_01_06_425584 183 29 metabolites metabolite NNS 10_1101-2021_01_06_425584 183 30 ( ( -LRB- 10_1101-2021_01_06_425584 183 31 seed seed NN 10_1101-2021_01_06_425584 183 32 metabolites metabolite NNS 10_1101-2021_01_06_425584 183 33 ) ) -RRB- 10_1101-2021_01_06_425584 183 34 , , , 10_1101-2021_01_06_425584 183 35 177 177 CD 10_1101-2021_01_06_425584 183 36 edges edge NNS 10_1101-2021_01_06_425584 183 37 , , , 10_1101-2021_01_06_425584 183 38 and and CC 10_1101-2021_01_06_425584 183 39 166 166 CD 10_1101-2021_01_06_425584 183 40 proteins protein NNS 10_1101-2021_01_06_425584 183 41 ( ( -LRB- 10_1101-2021_01_06_425584 183 42 5 5 CD 10_1101-2021_01_06_425584 183 43 seed seed NN 10_1101-2021_01_06_425584 183 44 355 355 CD 10_1101-2021_01_06_425584 183 45 .CC .CC : 10_1101-2021_01_06_425584 183 46 - - HYPH 10_1101-2021_01_06_425584 183 47 BY by IN 10_1101-2021_01_06_425584 183 48 - - HYPH 10_1101-2021_01_06_425584 183 49 NC NC NNP 10_1101-2021_01_06_425584 183 50 - - HYPH 10_1101-2021_01_06_425584 183 51 ND ND NNP 10_1101-2021_01_06_425584 183 52 4.0 4.0 CD 10_1101-2021_01_06_425584 183 53 International International NNP 10_1101-2021_01_06_425584 183 54 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 183 55 under under IN 10_1101-2021_01_06_425584 183 56 a a DT 10_1101-2021_01_06_425584 183 57 ( ( -LRB- 10_1101-2021_01_06_425584 183 58 which which WDT 10_1101-2021_01_06_425584 183 59 was be VBD 10_1101-2021_01_06_425584 183 60 not not RB 10_1101-2021_01_06_425584 183 61 certified certify VBN 10_1101-2021_01_06_425584 183 62 by by IN 10_1101-2021_01_06_425584 183 63 peer peer NN 10_1101-2021_01_06_425584 183 64 review review NN 10_1101-2021_01_06_425584 183 65 ) ) -RRB- 10_1101-2021_01_06_425584 183 66 is be VBZ 10_1101-2021_01_06_425584 183 67 the the DT 10_1101-2021_01_06_425584 183 68 author author NN 10_1101-2021_01_06_425584 183 69 / / SYM 10_1101-2021_01_06_425584 183 70 funder funder NN 10_1101-2021_01_06_425584 183 71 , , , 10_1101-2021_01_06_425584 183 72 who who WP 10_1101-2021_01_06_425584 183 73 has have VBZ 10_1101-2021_01_06_425584 183 74 granted grant VBN 10_1101-2021_01_06_425584 183 75 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 183 76 a a DT 10_1101-2021_01_06_425584 183 77 license license NN 10_1101-2021_01_06_425584 183 78 to to TO 10_1101-2021_01_06_425584 183 79 display display VB 10_1101-2021_01_06_425584 183 80 the the DT 10_1101-2021_01_06_425584 183 81 preprint preprint NN 10_1101-2021_01_06_425584 183 82 in in IN 10_1101-2021_01_06_425584 183 83 perpetuity perpetuity NN 10_1101-2021_01_06_425584 183 84 . . . 10_1101-2021_01_06_425584 184 1 It -PRON- PRP 10_1101-2021_01_06_425584 184 2 is be VBZ 10_1101-2021_01_06_425584 184 3 made make VBN 10_1101-2021_01_06_425584 184 4 The the DT 10_1101-2021_01_06_425584 184 5 copyright copyright NN 10_1101-2021_01_06_425584 184 6 holder holder NN 10_1101-2021_01_06_425584 184 7 for for IN 10_1101-2021_01_06_425584 184 8 this this DT 10_1101-2021_01_06_425584 184 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 184 10 version version NN 10_1101-2021_01_06_425584 184 11 posted post VBD 10_1101-2021_01_06_425584 184 12 January January NNP 10_1101-2021_01_06_425584 184 13 8 8 CD 10_1101-2021_01_06_425584 184 14 , , , 10_1101-2021_01_06_425584 184 15 2021 2021 CD 10_1101-2021_01_06_425584 184 16 . . . 10_1101-2021_01_06_425584 184 17 ; ; : 10_1101-2021_01_06_425584 184 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 184 19 : : : 10_1101-2021_01_06_425584 184 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 184 21 preprint preprint NN 10_1101-2021_01_06_425584 184 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 184 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 184 24 12 12 CD 10_1101-2021_01_06_425584 184 25 proteins protein NNS 10_1101-2021_01_06_425584 184 26 ) ) -RRB- 10_1101-2021_01_06_425584 184 27 . . . 10_1101-2021_01_06_425584 185 1 The the DT 10_1101-2021_01_06_425584 185 2 10 10 CD 10_1101-2021_01_06_425584 185 3 top top JJ 10_1101-2021_01_06_425584 185 4 - - HYPH 10_1101-2021_01_06_425584 185 5 most most RBS 10_1101-2021_01_06_425584 185 6 enriched enriched JJ 10_1101-2021_01_06_425584 185 7 signaling signal VBG 10_1101-2021_01_06_425584 185 8 pathways pathway NNS 10_1101-2021_01_06_425584 185 9 identified identify VBN 10_1101-2021_01_06_425584 185 10 in in IN 10_1101-2021_01_06_425584 185 11 the the DT 10_1101-2021_01_06_425584 185 12 composite composite JJ 10_1101-2021_01_06_425584 185 13 network network NN 10_1101-2021_01_06_425584 185 14 are be VBP 10_1101-2021_01_06_425584 185 15 356 356 CD 10_1101-2021_01_06_425584 185 16 shown show VBN 10_1101-2021_01_06_425584 185 17 in in IN 10_1101-2021_01_06_425584 185 18 Table table NN 10_1101-2021_01_06_425584 185 19 2 2 CD 10_1101-2021_01_06_425584 185 20 . . . 10_1101-2021_01_06_425584 186 1 The the DT 10_1101-2021_01_06_425584 186 2 two two CD 10_1101-2021_01_06_425584 186 3 principal principal JJ 10_1101-2021_01_06_425584 186 4 modules module NNS 10_1101-2021_01_06_425584 186 5 highlighted highlight VBN 10_1101-2021_01_06_425584 186 6 by by IN 10_1101-2021_01_06_425584 186 7 the the DT 10_1101-2021_01_06_425584 186 8 WalkTrap WalkTrap NNP 10_1101-2021_01_06_425584 186 9 algorithm algorithm NN 10_1101-2021_01_06_425584 186 10 were be VBD 10_1101-2021_01_06_425584 186 11 linked link VBN 10_1101-2021_01_06_425584 186 12 357 357 CD 10_1101-2021_01_06_425584 186 13 to to IN 10_1101-2021_01_06_425584 186 14 glutathione glutathione NN 10_1101-2021_01_06_425584 186 15 and and CC 10_1101-2021_01_06_425584 186 16 amino amino NN 10_1101-2021_01_06_425584 186 17 acid acid NN 10_1101-2021_01_06_425584 186 18 metabolism metabolism NN 10_1101-2021_01_06_425584 186 19 . . . 10_1101-2021_01_06_425584 187 1 We -PRON- PRP 10_1101-2021_01_06_425584 187 2 noted note VBD 10_1101-2021_01_06_425584 187 3 a a DT 10_1101-2021_01_06_425584 187 4 smaller small JJR 10_1101-2021_01_06_425584 187 5 interaction interaction NN 10_1101-2021_01_06_425584 187 6 between between IN 10_1101-2021_01_06_425584 187 7 Acyl Acyl NNP 10_1101-2021_01_06_425584 187 8 - - HYPH 10_1101-2021_01_06_425584 187 9 protein protein NN 10_1101-2021_01_06_425584 187 10 358 358 CD 10_1101-2021_01_06_425584 187 11 thioesterase thioesterase VBD 10_1101-2021_01_06_425584 187 12 1 1 CD 10_1101-2021_01_06_425584 187 13 ( ( -LRB- 10_1101-2021_01_06_425584 187 14 LYPLA1 LYPLA1 NNP 10_1101-2021_01_06_425584 187 15 ) ) -RRB- 10_1101-2021_01_06_425584 187 16 and and CC 10_1101-2021_01_06_425584 187 17 a a DT 10_1101-2021_01_06_425584 187 18 phosphatidylcholine phosphatidylcholine NN 10_1101-2021_01_06_425584 187 19 metabolite metabolite NN 10_1101-2021_01_06_425584 187 20 when when WRB 10_1101-2021_01_06_425584 187 21 simultaneously simultaneously RB 10_1101-2021_01_06_425584 187 22 analyzing analyze VBG 10_1101-2021_01_06_425584 187 23 359 359 CD 10_1101-2021_01_06_425584 187 24 up- up- CD 10_1101-2021_01_06_425584 187 25 and and CC 10_1101-2021_01_06_425584 187 26 down down RB 10_1101-2021_01_06_425584 187 27 - - HYPH 10_1101-2021_01_06_425584 187 28 modulated modulate VBN 10_1101-2021_01_06_425584 187 29 proteins protein NNS 10_1101-2021_01_06_425584 187 30 and and CC 10_1101-2021_01_06_425584 187 31 metabolites metabolite NNS 10_1101-2021_01_06_425584 187 32 . . . 10_1101-2021_01_06_425584 188 1 No no DT 10_1101-2021_01_06_425584 188 2 significant significant JJ 10_1101-2021_01_06_425584 188 3 composite composite JJ 10_1101-2021_01_06_425584 188 4 network network NN 10_1101-2021_01_06_425584 188 5 was be VBD 10_1101-2021_01_06_425584 188 6 360 360 CD 10_1101-2021_01_06_425584 188 7 identified identify VBN 10_1101-2021_01_06_425584 188 8 using use VBG 10_1101-2021_01_06_425584 188 9 the the DT 10_1101-2021_01_06_425584 188 10 down down RB 10_1101-2021_01_06_425584 188 11 - - HYPH 10_1101-2021_01_06_425584 188 12 modulated modulate VBN 10_1101-2021_01_06_425584 188 13 proteins protein NNS 10_1101-2021_01_06_425584 188 14 and and CC 10_1101-2021_01_06_425584 188 15 metabolites metabolite NNS 10_1101-2021_01_06_425584 188 16 . . . 10_1101-2021_01_06_425584 189 1 361 361 CD 10_1101-2021_01_06_425584 189 2 362 362 CD 10_1101-2021_01_06_425584 189 3 Cellular Cellular NNP 10_1101-2021_01_06_425584 189 4 morphology morphology NN 10_1101-2021_01_06_425584 189 5 363 363 CD 10_1101-2021_01_06_425584 189 6 To to TO 10_1101-2021_01_06_425584 189 7 better well RBR 10_1101-2021_01_06_425584 189 8 understand understand VB 10_1101-2021_01_06_425584 189 9 the the DT 10_1101-2021_01_06_425584 189 10 effects effect NNS 10_1101-2021_01_06_425584 189 11 that that WDT 10_1101-2021_01_06_425584 189 12 simulated simulate VBD 10_1101-2021_01_06_425584 189 13 diabetes diabetes NN 10_1101-2021_01_06_425584 189 14 exerts exert NNS 10_1101-2021_01_06_425584 189 15 on on IN 10_1101-2021_01_06_425584 189 16 endothelial endothelial JJ 10_1101-2021_01_06_425584 189 17 cells cell NNS 10_1101-2021_01_06_425584 189 18 the the DT 10_1101-2021_01_06_425584 189 19 changes change NNS 10_1101-2021_01_06_425584 189 20 364 364 CD 10_1101-2021_01_06_425584 189 21 on on IN 10_1101-2021_01_06_425584 189 22 cellular cellular JJ 10_1101-2021_01_06_425584 189 23 structure structure NN 10_1101-2021_01_06_425584 189 24 endpoints endpoint NNS 10_1101-2021_01_06_425584 189 25 were be VBD 10_1101-2021_01_06_425584 189 26 evaluated evaluate VBN 10_1101-2021_01_06_425584 189 27 . . . 10_1101-2021_01_06_425584 190 1 The the DT 10_1101-2021_01_06_425584 190 2 endothelial endothelial JJ 10_1101-2021_01_06_425584 190 3 nuclei nuclei NN 10_1101-2021_01_06_425584 190 4 morphology morphology NN 10_1101-2021_01_06_425584 190 5 in in IN 10_1101-2021_01_06_425584 190 6 the the DT 10_1101-2021_01_06_425584 190 7 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 190 8 365 365 CD 10_1101-2021_01_06_425584 190 9 control control NN 10_1101-2021_01_06_425584 190 10 and and CC 10_1101-2021_01_06_425584 190 11 experimental experimental JJ 10_1101-2021_01_06_425584 190 12 groups group NNS 10_1101-2021_01_06_425584 190 13 were be VBD 10_1101-2021_01_06_425584 190 14 evaluated evaluate VBN 10_1101-2021_01_06_425584 190 15 using use VBG 10_1101-2021_01_06_425584 190 16 fluorescent fluorescent NN 10_1101-2021_01_06_425584 190 17 - - HYPH 10_1101-2021_01_06_425584 190 18 staining staining NN 10_1101-2021_01_06_425584 190 19 and and CC 10_1101-2021_01_06_425584 190 20 image image NN 10_1101-2021_01_06_425584 190 21 analysis analysis NN 10_1101-2021_01_06_425584 190 22 . . . 10_1101-2021_01_06_425584 191 1 366 366 CD 10_1101-2021_01_06_425584 191 2 We -PRON- PRP 10_1101-2021_01_06_425584 191 3 also also RB 10_1101-2021_01_06_425584 191 4 evaluated evaluate VBD 10_1101-2021_01_06_425584 191 5 the the DT 10_1101-2021_01_06_425584 191 6 presence presence NN 10_1101-2021_01_06_425584 191 7 of of IN 10_1101-2021_01_06_425584 191 8 vWF vWF NNP 10_1101-2021_01_06_425584 191 9 ( ( -LRB- 10_1101-2021_01_06_425584 191 10 marker marker NN 10_1101-2021_01_06_425584 191 11 of of IN 10_1101-2021_01_06_425584 191 12 endothelial endothelial JJ 10_1101-2021_01_06_425584 191 13 cells cell NNS 10_1101-2021_01_06_425584 191 14 ) ) -RRB- 10_1101-2021_01_06_425584 191 15 in in IN 10_1101-2021_01_06_425584 191 16 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 191 17 and and CC 10_1101-2021_01_06_425584 191 18 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 191 19 , , , 10_1101-2021_01_06_425584 191 20 to to IN 10_1101-2021_01_06_425584 191 21 367 367 CD 10_1101-2021_01_06_425584 191 22 reveal reveal VB 10_1101-2021_01_06_425584 191 23 the the DT 10_1101-2021_01_06_425584 191 24 cellular cellular JJ 10_1101-2021_01_06_425584 191 25 boundary boundary NN 10_1101-2021_01_06_425584 191 26 and and CC 10_1101-2021_01_06_425584 191 27 to to TO 10_1101-2021_01_06_425584 191 28 demonstrate demonstrate VB 10_1101-2021_01_06_425584 191 29 their -PRON- PRP$ 10_1101-2021_01_06_425584 191 30 endothelial endothelial JJ 10_1101-2021_01_06_425584 191 31 phenotype phenotype NN 10_1101-2021_01_06_425584 191 32 ( ( -LRB- 10_1101-2021_01_06_425584 191 33 41 41 CD 10_1101-2021_01_06_425584 191 34 ) ) -RRB- 10_1101-2021_01_06_425584 191 35 . . . 10_1101-2021_01_06_425584 192 1 We -PRON- PRP 10_1101-2021_01_06_425584 192 2 noted note VBD 10_1101-2021_01_06_425584 192 3 an an DT 10_1101-2021_01_06_425584 192 4 368 368 CD 10_1101-2021_01_06_425584 192 5 increase increase NN 10_1101-2021_01_06_425584 192 6 in in IN 10_1101-2021_01_06_425584 192 7 the the DT 10_1101-2021_01_06_425584 192 8 percentage percentage NN 10_1101-2021_01_06_425584 192 9 of of IN 10_1101-2021_01_06_425584 192 10 binucleated binucleated JJ 10_1101-2021_01_06_425584 192 11 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 192 12 in in IN 10_1101-2021_01_06_425584 192 13 the the DT 10_1101-2021_01_06_425584 192 14 experimental experimental JJ 10_1101-2021_01_06_425584 192 15 group group NN 10_1101-2021_01_06_425584 192 16 compared compare VBN 10_1101-2021_01_06_425584 192 17 to to IN 10_1101-2021_01_06_425584 192 18 the the DT 10_1101-2021_01_06_425584 192 19 369 369 CD 10_1101-2021_01_06_425584 192 20 control control NN 10_1101-2021_01_06_425584 192 21 group group NN 10_1101-2021_01_06_425584 192 22 ( ( -LRB- 10_1101-2021_01_06_425584 192 23 top top JJ 10_1101-2021_01_06_425584 192 24 panel panel NN 10_1101-2021_01_06_425584 192 25 Figure figure NN 10_1101-2021_01_06_425584 192 26 7A 7a NN 10_1101-2021_01_06_425584 192 27 and and CC 10_1101-2021_01_06_425584 192 28 7B 7b NN 10_1101-2021_01_06_425584 192 29 ) ) -RRB- 10_1101-2021_01_06_425584 192 30 . . . 10_1101-2021_01_06_425584 193 1 A a DT 10_1101-2021_01_06_425584 193 2 similar similar JJ 10_1101-2021_01_06_425584 193 3 result result NN 10_1101-2021_01_06_425584 193 4 with with IN 10_1101-2021_01_06_425584 193 5 larger large JJR 10_1101-2021_01_06_425584 193 6 nuclei nucleus NNS 10_1101-2021_01_06_425584 193 7 , , , 10_1101-2021_01_06_425584 193 8 was be VBD 10_1101-2021_01_06_425584 193 9 observed observe VBN 10_1101-2021_01_06_425584 193 10 370 370 CD 10_1101-2021_01_06_425584 193 11 when when WRB 10_1101-2021_01_06_425584 193 12 using use VBG 10_1101-2021_01_06_425584 193 13 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 193 14 as as IN 10_1101-2021_01_06_425584 193 15 a a DT 10_1101-2021_01_06_425584 193 16 human human NN 10_1101-2021_01_06_425584 193 17 in in FW 10_1101-2021_01_06_425584 193 18 vitro vitro FW 10_1101-2021_01_06_425584 193 19 model model NN 10_1101-2021_01_06_425584 193 20 ( ( -LRB- 10_1101-2021_01_06_425584 193 21 bottom bottom JJ 10_1101-2021_01_06_425584 193 22 panel panel NN 10_1101-2021_01_06_425584 193 23 Figure figure NN 10_1101-2021_01_06_425584 193 24 7A 7a NN 10_1101-2021_01_06_425584 193 25 and and CC 10_1101-2021_01_06_425584 193 26 7B 7b NN 10_1101-2021_01_06_425584 193 27 ) ) -RRB- 10_1101-2021_01_06_425584 193 28 . . . 10_1101-2021_01_06_425584 194 1 Finally finally RB 10_1101-2021_01_06_425584 194 2 , , , 10_1101-2021_01_06_425584 194 3 as as IN 10_1101-2021_01_06_425584 194 4 371 371 CD 10_1101-2021_01_06_425584 194 5 expected expect VBN 10_1101-2021_01_06_425584 194 6 , , , 10_1101-2021_01_06_425584 194 7 we -PRON- PRP 10_1101-2021_01_06_425584 194 8 observed observe VBD 10_1101-2021_01_06_425584 194 9 a a DT 10_1101-2021_01_06_425584 194 10 typical typical JJ 10_1101-2021_01_06_425584 194 11 intracellular intracellular JJ 10_1101-2021_01_06_425584 194 12 localization localization NN 10_1101-2021_01_06_425584 194 13 of of IN 10_1101-2021_01_06_425584 194 14 vWF vWF NNP 10_1101-2021_01_06_425584 194 15 and and CC 10_1101-2021_01_06_425584 194 16 a a DT 10_1101-2021_01_06_425584 194 17 100 100 CD 10_1101-2021_01_06_425584 194 18 % % NN 10_1101-2021_01_06_425584 194 19 positivity positivity NN 10_1101-2021_01_06_425584 194 20 in in IN 10_1101-2021_01_06_425584 194 21 372 372 CD 10_1101-2021_01_06_425584 194 22 endothelial endothelial JJ 10_1101-2021_01_06_425584 194 23 cells cell NNS 10_1101-2021_01_06_425584 194 24 . . . 10_1101-2021_01_06_425584 195 1 373 373 CD 10_1101-2021_01_06_425584 195 2 374 374 CD 10_1101-2021_01_06_425584 195 3 4 4 CD 10_1101-2021_01_06_425584 195 4 . . . 10_1101-2021_01_06_425584 196 1 Discussion discussion NN 10_1101-2021_01_06_425584 196 2 375 375 CD 10_1101-2021_01_06_425584 196 3 This this DT 10_1101-2021_01_06_425584 196 4 study study NN 10_1101-2021_01_06_425584 196 5 investigated investigate VBD 10_1101-2021_01_06_425584 196 6 the the DT 10_1101-2021_01_06_425584 196 7 molecular molecular JJ 10_1101-2021_01_06_425584 196 8 perturbations perturbation NNS 10_1101-2021_01_06_425584 196 9 occurring occur VBG 10_1101-2021_01_06_425584 196 10 in in IN 10_1101-2021_01_06_425584 196 11 coronary coronary JJ 10_1101-2021_01_06_425584 196 12 endothelium endothelium NN 10_1101-2021_01_06_425584 196 13 cells cell NNS 10_1101-2021_01_06_425584 196 14 376 376 CD 10_1101-2021_01_06_425584 196 15 subjected subject VBN 10_1101-2021_01_06_425584 196 16 to to IN 10_1101-2021_01_06_425584 196 17 prolonged prolonged JJ 10_1101-2021_01_06_425584 196 18 simulated simulated JJ 10_1101-2021_01_06_425584 196 19 diabetes diabete NNS 10_1101-2021_01_06_425584 196 20 that that WDT 10_1101-2021_01_06_425584 196 21 facilitated facilitate VBD 10_1101-2021_01_06_425584 196 22 the the DT 10_1101-2021_01_06_425584 196 23 identification identification NN 10_1101-2021_01_06_425584 196 24 of of IN 10_1101-2021_01_06_425584 196 25 signaling signal VBG 10_1101-2021_01_06_425584 196 26 pathways pathway NNS 10_1101-2021_01_06_425584 196 27 377 377 CD 10_1101-2021_01_06_425584 196 28 and and CC 10_1101-2021_01_06_425584 196 29 specific specific JJ 10_1101-2021_01_06_425584 196 30 molecules molecule NNS 10_1101-2021_01_06_425584 196 31 that that WDT 10_1101-2021_01_06_425584 196 32 could could MD 10_1101-2021_01_06_425584 196 33 be be VB 10_1101-2021_01_06_425584 196 34 associated associate VBN 10_1101-2021_01_06_425584 196 35 with with IN 10_1101-2021_01_06_425584 196 36 the the DT 10_1101-2021_01_06_425584 196 37 development development NN 10_1101-2021_01_06_425584 196 38 of of IN 10_1101-2021_01_06_425584 196 39 cardiovascular cardiovascular JJ 10_1101-2021_01_06_425584 196 40 disease disease NN 10_1101-2021_01_06_425584 196 41 . . . 10_1101-2021_01_06_425584 197 1 378 378 CD 10_1101-2021_01_06_425584 197 2 To to TO 10_1101-2021_01_06_425584 197 3 achieve achieve VB 10_1101-2021_01_06_425584 197 4 this this DT 10_1101-2021_01_06_425584 197 5 , , , 10_1101-2021_01_06_425584 197 6 we -PRON- PRP 10_1101-2021_01_06_425584 197 7 employed employ VBD 10_1101-2021_01_06_425584 197 8 a a DT 10_1101-2021_01_06_425584 197 9 MS MS NNP 10_1101-2021_01_06_425584 197 10 - - HYPH 10_1101-2021_01_06_425584 197 11 based base VBN 10_1101-2021_01_06_425584 197 12 multi multi JJ 10_1101-2021_01_06_425584 197 13 - - HYPH 10_1101-2021_01_06_425584 197 14 omics omics JJ 10_1101-2021_01_06_425584 197 15 approach approach NN 10_1101-2021_01_06_425584 197 16 coupled couple VBN 10_1101-2021_01_06_425584 197 17 to to TO 10_1101-2021_01_06_425584 197 18 fluorescence fluorescence VB 10_1101-2021_01_06_425584 197 19 379 379 CD 10_1101-2021_01_06_425584 197 20 microscopy microscopy JJ 10_1101-2021_01_06_425584 197 21 to to TO 10_1101-2021_01_06_425584 197 22 detect detect VB 10_1101-2021_01_06_425584 197 23 structural structural JJ 10_1101-2021_01_06_425584 197 24 changes change NNS 10_1101-2021_01_06_425584 197 25 . . . 10_1101-2021_01_06_425584 198 1 Endothelial endothelial JJ 10_1101-2021_01_06_425584 198 2 cells cell NNS 10_1101-2021_01_06_425584 198 3 cover cover VBP 10_1101-2021_01_06_425584 198 4 the the DT 10_1101-2021_01_06_425584 198 5 inner inner JJ 10_1101-2021_01_06_425584 198 6 surface surface NN 10_1101-2021_01_06_425584 198 7 of of IN 10_1101-2021_01_06_425584 198 8 blood blood NN 10_1101-2021_01_06_425584 198 9 vessels vessel NNS 10_1101-2021_01_06_425584 198 10 380 380 CD 10_1101-2021_01_06_425584 198 11 and and CC 10_1101-2021_01_06_425584 198 12 are be VBP 10_1101-2021_01_06_425584 198 13 distributed distribute VBN 10_1101-2021_01_06_425584 198 14 across across IN 10_1101-2021_01_06_425584 198 15 the the DT 10_1101-2021_01_06_425584 198 16 body body NN 10_1101-2021_01_06_425584 198 17 . . . 10_1101-2021_01_06_425584 199 1 Their -PRON- PRP$ 10_1101-2021_01_06_425584 199 2 functions function NNS 10_1101-2021_01_06_425584 199 3 include include VBP 10_1101-2021_01_06_425584 199 4 : : : 10_1101-2021_01_06_425584 199 5 acting act VBG 10_1101-2021_01_06_425584 199 6 as as IN 10_1101-2021_01_06_425584 199 7 a a DT 10_1101-2021_01_06_425584 199 8 mechanical mechanical JJ 10_1101-2021_01_06_425584 199 9 barrier barrier NN 10_1101-2021_01_06_425584 199 10 381 381 CD 10_1101-2021_01_06_425584 199 11 between between IN 10_1101-2021_01_06_425584 199 12 the the DT 10_1101-2021_01_06_425584 199 13 circulating circulate VBG 10_1101-2021_01_06_425584 199 14 blood blood NN 10_1101-2021_01_06_425584 199 15 and and CC 10_1101-2021_01_06_425584 199 16 adjacent adjacent JJ 10_1101-2021_01_06_425584 199 17 tissues tissue NNS 10_1101-2021_01_06_425584 199 18 as as RB 10_1101-2021_01_06_425584 199 19 well well RB 10_1101-2021_01_06_425584 199 20 as as IN 10_1101-2021_01_06_425584 199 21 modulating modulate VBG 10_1101-2021_01_06_425584 199 22 multiple multiple JJ 10_1101-2021_01_06_425584 199 23 functions function NNS 10_1101-2021_01_06_425584 199 24 in in IN 10_1101-2021_01_06_425584 199 25 382 382 CD 10_1101-2021_01_06_425584 199 26 distinct distinct JJ 10_1101-2021_01_06_425584 199 27 organs organ NNS 10_1101-2021_01_06_425584 199 28 ( ( -LRB- 10_1101-2021_01_06_425584 199 29 42 42 CD 10_1101-2021_01_06_425584 199 30 ) ) -RRB- 10_1101-2021_01_06_425584 199 31 . . . 10_1101-2021_01_06_425584 200 1 These these DT 10_1101-2021_01_06_425584 200 2 regulatory regulatory JJ 10_1101-2021_01_06_425584 200 3 functions function NNS 10_1101-2021_01_06_425584 200 4 vary vary VBP 10_1101-2021_01_06_425584 200 5 according accord VBG 10_1101-2021_01_06_425584 200 6 to to IN 10_1101-2021_01_06_425584 200 7 localization localization NN 10_1101-2021_01_06_425584 200 8 and and CC 10_1101-2021_01_06_425584 200 9 vascular vascular JJ 10_1101-2021_01_06_425584 200 10 bed-383 bed-383 NNP 10_1101-2021_01_06_425584 200 11 origin origin NN 10_1101-2021_01_06_425584 200 12 ( ( -LRB- 10_1101-2021_01_06_425584 200 13 43 43 CD 10_1101-2021_01_06_425584 200 14 ) ) -RRB- 10_1101-2021_01_06_425584 200 15 . . . 10_1101-2021_01_06_425584 201 1 HG HG NNP 10_1101-2021_01_06_425584 201 2 blood blood NN 10_1101-2021_01_06_425584 201 3 levels level NNS 10_1101-2021_01_06_425584 201 4 are be VBP 10_1101-2021_01_06_425584 201 5 detrimental detrimental JJ 10_1101-2021_01_06_425584 201 6 to to IN 10_1101-2021_01_06_425584 201 7 endothelial endothelial JJ 10_1101-2021_01_06_425584 201 8 cells cell NNS 10_1101-2021_01_06_425584 201 9 function function NN 10_1101-2021_01_06_425584 201 10 in in IN 10_1101-2021_01_06_425584 201 11 T2DM T2DM NNP 10_1101-2021_01_06_425584 201 12 leading lead VBG 10_1101-2021_01_06_425584 201 13 to to IN 10_1101-2021_01_06_425584 201 14 384 384 CD 10_1101-2021_01_06_425584 201 15 coronary coronary JJ 10_1101-2021_01_06_425584 201 16 endothelial endothelial JJ 10_1101-2021_01_06_425584 201 17 dysfunction dysfunction NN 10_1101-2021_01_06_425584 201 18 and and CC 10_1101-2021_01_06_425584 201 19 development development NN 10_1101-2021_01_06_425584 201 20 of of IN 10_1101-2021_01_06_425584 201 21 CVD CVD NNP 10_1101-2021_01_06_425584 201 22 ( ( -LRB- 10_1101-2021_01_06_425584 201 23 44 44 CD 10_1101-2021_01_06_425584 201 24 , , , 10_1101-2021_01_06_425584 201 25 45 45 CD 10_1101-2021_01_06_425584 201 26 ) ) -RRB- 10_1101-2021_01_06_425584 201 27 . . . 10_1101-2021_01_06_425584 202 1 The the DT 10_1101-2021_01_06_425584 202 2 molecular molecular JJ 10_1101-2021_01_06_425584 202 3 effects effect NNS 10_1101-2021_01_06_425584 202 4 of of IN 10_1101-2021_01_06_425584 202 5 HG HG NNP 10_1101-2021_01_06_425584 202 6 385 385 CD 10_1101-2021_01_06_425584 202 7 on on IN 10_1101-2021_01_06_425584 202 8 endothelial endothelial JJ 10_1101-2021_01_06_425584 202 9 cells cell NNS 10_1101-2021_01_06_425584 202 10 have have VBP 10_1101-2021_01_06_425584 202 11 been be VBN 10_1101-2021_01_06_425584 202 12 previously previously RB 10_1101-2021_01_06_425584 202 13 characterized characterize VBN 10_1101-2021_01_06_425584 202 14 ( ( -LRB- 10_1101-2021_01_06_425584 202 15 4 4 CD 10_1101-2021_01_06_425584 202 16 , , , 10_1101-2021_01_06_425584 202 17 6 6 CD 10_1101-2021_01_06_425584 202 18 , , , 10_1101-2021_01_06_425584 202 19 7 7 CD 10_1101-2021_01_06_425584 202 20 , , , 10_1101-2021_01_06_425584 202 21 10 10 CD 10_1101-2021_01_06_425584 202 22 , , , 10_1101-2021_01_06_425584 202 23 11 11 CD 10_1101-2021_01_06_425584 202 24 ) ) -RRB- 10_1101-2021_01_06_425584 202 25 ; ; : 10_1101-2021_01_06_425584 202 26 nevertheless nevertheless RB 10_1101-2021_01_06_425584 202 27 , , , 10_1101-2021_01_06_425584 202 28 the the DT 10_1101-2021_01_06_425584 202 29 386 386 CD 10_1101-2021_01_06_425584 202 30 endothelial endothelial JJ 10_1101-2021_01_06_425584 202 31 cell cell NN 10_1101-2021_01_06_425584 202 32 types type NNS 10_1101-2021_01_06_425584 202 33 used use VBN 10_1101-2021_01_06_425584 202 34 in in IN 10_1101-2021_01_06_425584 202 35 these these DT 10_1101-2021_01_06_425584 202 36 studies study NNS 10_1101-2021_01_06_425584 202 37 are be VBP 10_1101-2021_01_06_425584 202 38 not not RB 10_1101-2021_01_06_425584 202 39 intrinsically intrinsically RB 10_1101-2021_01_06_425584 202 40 involved involve VBN 10_1101-2021_01_06_425584 202 41 in in IN 10_1101-2021_01_06_425584 202 42 CVD CVD NNP 10_1101-2021_01_06_425584 202 43 . . . 10_1101-2021_01_06_425584 203 1 The the DT 10_1101-2021_01_06_425584 203 2 present present JJ 10_1101-2021_01_06_425584 203 3 study study NN 10_1101-2021_01_06_425584 203 4 387 387 CD 10_1101-2021_01_06_425584 203 5 used use VBD 10_1101-2021_01_06_425584 203 6 an an DT 10_1101-2021_01_06_425584 203 7 in in FW 10_1101-2021_01_06_425584 203 8 vitro vitro FW 10_1101-2021_01_06_425584 203 9 model model NN 10_1101-2021_01_06_425584 203 10 involving involve VBG 10_1101-2021_01_06_425584 203 11 endothelial endothelial JJ 10_1101-2021_01_06_425584 203 12 cells cell NNS 10_1101-2021_01_06_425584 203 13 that that WDT 10_1101-2021_01_06_425584 203 14 modulate modulate VBP 10_1101-2021_01_06_425584 203 15 the the DT 10_1101-2021_01_06_425584 203 16 heart heart NN 10_1101-2021_01_06_425584 203 17 function function NN 10_1101-2021_01_06_425584 203 18 , , , 10_1101-2021_01_06_425584 203 19 CAEC CAEC NNP 10_1101-2021_01_06_425584 203 20 ( ( -LRB- 10_1101-2021_01_06_425584 203 21 46 46 CD 10_1101-2021_01_06_425584 203 22 ) ) -RRB- 10_1101-2021_01_06_425584 203 23 . . . 10_1101-2021_01_06_425584 204 1 388 388 CD 10_1101-2021_01_06_425584 204 2 Our -PRON- PRP$ 10_1101-2021_01_06_425584 204 3 model model NN 10_1101-2021_01_06_425584 204 4 not not RB 10_1101-2021_01_06_425584 204 5 only only RB 10_1101-2021_01_06_425584 204 6 used use VBN 10_1101-2021_01_06_425584 204 7 HG HG NNP 10_1101-2021_01_06_425584 204 8 ( ( -LRB- 10_1101-2021_01_06_425584 204 9 20 20 CD 10_1101-2021_01_06_425584 204 10 mmol mmol NN 10_1101-2021_01_06_425584 204 11 / / SYM 10_1101-2021_01_06_425584 204 12 L l NN 10_1101-2021_01_06_425584 204 13 ) ) -RRB- 10_1101-2021_01_06_425584 204 14 to to TO 10_1101-2021_01_06_425584 204 15 simulate simulate VB 10_1101-2021_01_06_425584 204 16 diabetes diabete NNS 10_1101-2021_01_06_425584 204 17 ( ( -LRB- 10_1101-2021_01_06_425584 204 18 4 4 CD 10_1101-2021_01_06_425584 204 19 , , , 10_1101-2021_01_06_425584 204 20 6 6 CD 10_1101-2021_01_06_425584 204 21 , , , 10_1101-2021_01_06_425584 204 22 7 7 CD 10_1101-2021_01_06_425584 204 23 , , , 10_1101-2021_01_06_425584 204 24 10 10 CD 10_1101-2021_01_06_425584 204 25 , , , 10_1101-2021_01_06_425584 204 26 11 11 CD 10_1101-2021_01_06_425584 204 27 ) ) -RRB- 10_1101-2021_01_06_425584 204 28 but but CC 10_1101-2021_01_06_425584 204 29 first first RB 10_1101-2021_01_06_425584 204 30 induced induce VBD 10_1101-2021_01_06_425584 204 31 389 389 CD 10_1101-2021_01_06_425584 204 32 .CC .CC : 10_1101-2021_01_06_425584 204 33 - - HYPH 10_1101-2021_01_06_425584 204 34 BY by IN 10_1101-2021_01_06_425584 204 35 - - HYPH 10_1101-2021_01_06_425584 204 36 NC NC NNP 10_1101-2021_01_06_425584 204 37 - - HYPH 10_1101-2021_01_06_425584 204 38 ND ND NNP 10_1101-2021_01_06_425584 204 39 4.0 4.0 CD 10_1101-2021_01_06_425584 204 40 International International NNP 10_1101-2021_01_06_425584 204 41 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 204 42 under under IN 10_1101-2021_01_06_425584 204 43 a a DT 10_1101-2021_01_06_425584 204 44 ( ( -LRB- 10_1101-2021_01_06_425584 204 45 which which WDT 10_1101-2021_01_06_425584 204 46 was be VBD 10_1101-2021_01_06_425584 204 47 not not RB 10_1101-2021_01_06_425584 204 48 certified certify VBN 10_1101-2021_01_06_425584 204 49 by by IN 10_1101-2021_01_06_425584 204 50 peer peer NN 10_1101-2021_01_06_425584 204 51 review review NN 10_1101-2021_01_06_425584 204 52 ) ) -RRB- 10_1101-2021_01_06_425584 204 53 is be VBZ 10_1101-2021_01_06_425584 204 54 the the DT 10_1101-2021_01_06_425584 204 55 author author NN 10_1101-2021_01_06_425584 204 56 / / SYM 10_1101-2021_01_06_425584 204 57 funder funder NN 10_1101-2021_01_06_425584 204 58 , , , 10_1101-2021_01_06_425584 204 59 who who WP 10_1101-2021_01_06_425584 204 60 has have VBZ 10_1101-2021_01_06_425584 204 61 granted grant VBN 10_1101-2021_01_06_425584 204 62 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 204 63 a a DT 10_1101-2021_01_06_425584 204 64 license license NN 10_1101-2021_01_06_425584 204 65 to to TO 10_1101-2021_01_06_425584 204 66 display display VB 10_1101-2021_01_06_425584 204 67 the the DT 10_1101-2021_01_06_425584 204 68 preprint preprint NN 10_1101-2021_01_06_425584 204 69 in in IN 10_1101-2021_01_06_425584 204 70 perpetuity perpetuity NN 10_1101-2021_01_06_425584 204 71 . . . 10_1101-2021_01_06_425584 205 1 It -PRON- PRP 10_1101-2021_01_06_425584 205 2 is be VBZ 10_1101-2021_01_06_425584 205 3 made make VBN 10_1101-2021_01_06_425584 205 4 The the DT 10_1101-2021_01_06_425584 205 5 copyright copyright NN 10_1101-2021_01_06_425584 205 6 holder holder NN 10_1101-2021_01_06_425584 205 7 for for IN 10_1101-2021_01_06_425584 205 8 this this DT 10_1101-2021_01_06_425584 205 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 205 10 version version NN 10_1101-2021_01_06_425584 205 11 posted post VBD 10_1101-2021_01_06_425584 205 12 January January NNP 10_1101-2021_01_06_425584 205 13 8 8 CD 10_1101-2021_01_06_425584 205 14 , , , 10_1101-2021_01_06_425584 205 15 2021 2021 CD 10_1101-2021_01_06_425584 205 16 . . . 10_1101-2021_01_06_425584 205 17 ; ; : 10_1101-2021_01_06_425584 205 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 205 19 : : : 10_1101-2021_01_06_425584 205 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 205 21 preprint preprint NN 10_1101-2021_01_06_425584 205 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 205 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ JJ 10_1101-2021_01_06_425584 205 24 13 13 CD 10_1101-2021_01_06_425584 205 25 insulin insulin NN 10_1101-2021_01_06_425584 205 26 resistance resistance NN 10_1101-2021_01_06_425584 205 27 to to TO 10_1101-2021_01_06_425584 205 28 mimic mimic VB 10_1101-2021_01_06_425584 205 29 the the DT 10_1101-2021_01_06_425584 205 30 pathophysiological pathophysiological JJ 10_1101-2021_01_06_425584 205 31 conditions condition NNS 10_1101-2021_01_06_425584 205 32 that that WDT 10_1101-2021_01_06_425584 205 33 occur occur VBP 10_1101-2021_01_06_425584 205 34 in in IN 10_1101-2021_01_06_425584 205 35 T2DM T2DM NNP 10_1101-2021_01_06_425584 205 36 wherein wherein WRB 10_1101-2021_01_06_425584 205 37 390 390 CD 10_1101-2021_01_06_425584 205 38 hyperinsulinemia hyperinsulinemia NN 10_1101-2021_01_06_425584 205 39 precedes precedes NNPS 10_1101-2021_01_06_425584 205 40 hyperglycemia hyperglycemia NNP 10_1101-2021_01_06_425584 205 41 ( ( -LRB- 10_1101-2021_01_06_425584 205 42 18 18 CD 10_1101-2021_01_06_425584 205 43 ) ) -RRB- 10_1101-2021_01_06_425584 205 44 . . . 10_1101-2021_01_06_425584 206 1 Diabetes diabete NNS 10_1101-2021_01_06_425584 206 2 was be VBD 10_1101-2021_01_06_425584 206 3 simulated simulate VBN 10_1101-2021_01_06_425584 206 4 for for IN 10_1101-2021_01_06_425584 206 5 up up IN 10_1101-2021_01_06_425584 206 6 to to TO 10_1101-2021_01_06_425584 206 7 12 12 CD 10_1101-2021_01_06_425584 206 8 days day NNS 10_1101-2021_01_06_425584 206 9 to to IN 10_1101-2021_01_06_425584 206 10 391 391 CD 10_1101-2021_01_06_425584 206 11 mimic mimic JJ 10_1101-2021_01_06_425584 206 12 chronic chronic JJ 10_1101-2021_01_06_425584 206 13 HG HG NNP 10_1101-2021_01_06_425584 206 14 exposure exposure NN 10_1101-2021_01_06_425584 206 15 and and CC 10_1101-2021_01_06_425584 206 16 to to TO 10_1101-2021_01_06_425584 206 17 prevent prevent VB 10_1101-2021_01_06_425584 206 18 measuring measure VBG 10_1101-2021_01_06_425584 206 19 cell cell NN 10_1101-2021_01_06_425584 206 20 proliferation proliferation NN 10_1101-2021_01_06_425584 206 21 known know VBN 10_1101-2021_01_06_425584 206 22 to to TO 10_1101-2021_01_06_425584 206 23 occur occur VB 10_1101-2021_01_06_425584 206 24 in in IN 10_1101-2021_01_06_425584 206 25 early early JJ 10_1101-2021_01_06_425584 206 26 392 392 CD 10_1101-2021_01_06_425584 206 27 HG HG NNS 10_1101-2021_01_06_425584 206 28 ( ( -LRB- 10_1101-2021_01_06_425584 206 29 10 10 CD 10_1101-2021_01_06_425584 206 30 , , , 10_1101-2021_01_06_425584 206 31 16 16 CD 10_1101-2021_01_06_425584 206 32 ) ) -RRB- 10_1101-2021_01_06_425584 206 33 . . . 10_1101-2021_01_06_425584 207 1 Despite despite IN 10_1101-2021_01_06_425584 207 2 a a DT 10_1101-2021_01_06_425584 207 3 lack lack NN 10_1101-2021_01_06_425584 207 4 of of IN 10_1101-2021_01_06_425584 207 5 apparent apparent JJ 10_1101-2021_01_06_425584 207 6 increase increase NN 10_1101-2021_01_06_425584 207 7 in in IN 10_1101-2021_01_06_425584 207 8 cell cell NN 10_1101-2021_01_06_425584 207 9 proliferation proliferation NN 10_1101-2021_01_06_425584 207 10 in in IN 10_1101-2021_01_06_425584 207 11 the the DT 10_1101-2021_01_06_425584 207 12 experimental experimental JJ 10_1101-2021_01_06_425584 207 13 group group NN 10_1101-2021_01_06_425584 207 14 393 393 CD 10_1101-2021_01_06_425584 207 15 compared compare VBN 10_1101-2021_01_06_425584 207 16 to to TO 10_1101-2021_01_06_425584 207 17 control control VB 10_1101-2021_01_06_425584 207 18 group group NN 10_1101-2021_01_06_425584 207 19 after after IN 10_1101-2021_01_06_425584 207 20 twelve twelve CD 10_1101-2021_01_06_425584 207 21 days day NNS 10_1101-2021_01_06_425584 207 22 , , , 10_1101-2021_01_06_425584 207 23 an an DT 10_1101-2021_01_06_425584 207 24 increase increase NN 10_1101-2021_01_06_425584 207 25 in in IN 10_1101-2021_01_06_425584 207 26 overall overall JJ 10_1101-2021_01_06_425584 207 27 protein protein NN 10_1101-2021_01_06_425584 207 28 abundance abundance NN 10_1101-2021_01_06_425584 207 29 was be VBD 10_1101-2021_01_06_425584 207 30 394 394 CD 10_1101-2021_01_06_425584 207 31 detected detect VBN 10_1101-2021_01_06_425584 207 32 by by IN 10_1101-2021_01_06_425584 207 33 Bradford Bradford NNP 10_1101-2021_01_06_425584 207 34 assay assay NNP 10_1101-2021_01_06_425584 207 35 ( ( -LRB- 10_1101-2021_01_06_425584 207 36 data datum NNS 10_1101-2021_01_06_425584 207 37 not not RB 10_1101-2021_01_06_425584 207 38 shown show VBN 10_1101-2021_01_06_425584 207 39 ) ) -RRB- 10_1101-2021_01_06_425584 207 40 and and CC 10_1101-2021_01_06_425584 207 41 inferred infer VBN 10_1101-2021_01_06_425584 207 42 from from IN 10_1101-2021_01_06_425584 207 43 total total JJ 10_1101-2021_01_06_425584 207 44 ion ion NN 10_1101-2021_01_06_425584 207 45 chromatogram chromatogram NNP 10_1101-2021_01_06_425584 207 46 ( ( -LRB- 10_1101-2021_01_06_425584 207 47 TIC TIC NNP 10_1101-2021_01_06_425584 207 48 ) ) -RRB- 10_1101-2021_01_06_425584 207 49 of of IN 10_1101-2021_01_06_425584 207 50 395 395 CD 10_1101-2021_01_06_425584 207 51 MS MS NNP 10_1101-2021_01_06_425584 207 52 ( ( -LRB- 10_1101-2021_01_06_425584 207 53 Figure Figure NNP 10_1101-2021_01_06_425584 207 54 S1A s1a NN 10_1101-2021_01_06_425584 207 55 ) ) -RRB- 10_1101-2021_01_06_425584 207 56 . . . 10_1101-2021_01_06_425584 208 1 We -PRON- PRP 10_1101-2021_01_06_425584 208 2 suggest suggest VBP 10_1101-2021_01_06_425584 208 3 that that IN 10_1101-2021_01_06_425584 208 4 protein protein NN 10_1101-2021_01_06_425584 208 5 synthesis synthesis NN 10_1101-2021_01_06_425584 208 6 is be VBZ 10_1101-2021_01_06_425584 208 7 increased increase VBN 10_1101-2021_01_06_425584 208 8 as as IN 10_1101-2021_01_06_425584 208 9 a a DT 10_1101-2021_01_06_425584 208 10 consequence consequence NN 10_1101-2021_01_06_425584 208 11 of of IN 10_1101-2021_01_06_425584 208 12 the the DT 10_1101-2021_01_06_425584 208 13 higher high JJR 10_1101-2021_01_06_425584 208 14 396 396 CD 10_1101-2021_01_06_425584 208 15 presence presence NN 10_1101-2021_01_06_425584 208 16 of of IN 10_1101-2021_01_06_425584 208 17 bi bi JJ 10_1101-2021_01_06_425584 208 18 - - JJ 10_1101-2021_01_06_425584 208 19 nucleated nucleate VBN 10_1101-2021_01_06_425584 208 20 CAEC CAEC NNP 10_1101-2021_01_06_425584 208 21 ( ( -LRB- 10_1101-2021_01_06_425584 208 22 with with IN 10_1101-2021_01_06_425584 208 23 increased increase VBN 10_1101-2021_01_06_425584 208 24 DNA DNA NNP 10_1101-2021_01_06_425584 208 25 / / SYM 10_1101-2021_01_06_425584 208 26 RNA RNA NNP 10_1101-2021_01_06_425584 208 27 metabolism metabolism NN 10_1101-2021_01_06_425584 208 28 ) ) -RRB- 10_1101-2021_01_06_425584 208 29 under under IN 10_1101-2021_01_06_425584 208 30 HG HG NNP 10_1101-2021_01_06_425584 208 31 + + CC 10_1101-2021_01_06_425584 208 32 HI HI NNP 10_1101-2021_01_06_425584 208 33 compared compare VBN 10_1101-2021_01_06_425584 208 34 397 397 CD 10_1101-2021_01_06_425584 208 35 to to IN 10_1101-2021_01_06_425584 208 36 that that DT 10_1101-2021_01_06_425584 208 37 in in IN 10_1101-2021_01_06_425584 208 38 the the DT 10_1101-2021_01_06_425584 208 39 control control NN 10_1101-2021_01_06_425584 208 40 cohort cohort NN 10_1101-2021_01_06_425584 208 41 ( ( -LRB- 10_1101-2021_01_06_425584 208 42 Figure figure NN 10_1101-2021_01_06_425584 208 43 7A 7a NN 10_1101-2021_01_06_425584 208 44 and and CC 10_1101-2021_01_06_425584 208 45 7B 7b NN 10_1101-2021_01_06_425584 208 46 ) ) -RRB- 10_1101-2021_01_06_425584 208 47 . . . 10_1101-2021_01_06_425584 209 1 Previous previous JJ 10_1101-2021_01_06_425584 209 2 studies study NNS 10_1101-2021_01_06_425584 209 3 have have VBP 10_1101-2021_01_06_425584 209 4 shown show VBN 10_1101-2021_01_06_425584 209 5 reduced reduce VBN 10_1101-2021_01_06_425584 209 6 endothelial endothelial JJ 10_1101-2021_01_06_425584 209 7 398 398 CD 10_1101-2021_01_06_425584 209 8 cell cell NN 10_1101-2021_01_06_425584 209 9 proliferation proliferation NN 10_1101-2021_01_06_425584 209 10 ( ( -LRB- 10_1101-2021_01_06_425584 209 11 mostly mostly RB 10_1101-2021_01_06_425584 209 12 in in IN 10_1101-2021_01_06_425584 209 13 HUVEC HUVEC NNP 10_1101-2021_01_06_425584 209 14 ) ) -RRB- 10_1101-2021_01_06_425584 209 15 after after IN 10_1101-2021_01_06_425584 209 16 long long JJ 10_1101-2021_01_06_425584 209 17 - - HYPH 10_1101-2021_01_06_425584 209 18 term term NN 10_1101-2021_01_06_425584 209 19 ( ( -LRB- 10_1101-2021_01_06_425584 209 20 7 7 CD 10_1101-2021_01_06_425584 209 21 - - SYM 10_1101-2021_01_06_425584 209 22 14 14 CD 10_1101-2021_01_06_425584 209 23 days day NNS 10_1101-2021_01_06_425584 209 24 ) ) -RRB- 10_1101-2021_01_06_425584 209 25 HG HG NNP 10_1101-2021_01_06_425584 209 26 exposure exposure NN 10_1101-2021_01_06_425584 209 27 ( ( -LRB- 10_1101-2021_01_06_425584 209 28 4 4 CD 10_1101-2021_01_06_425584 209 29 , , , 10_1101-2021_01_06_425584 209 30 11 11 CD 10_1101-2021_01_06_425584 209 31 , , , 10_1101-2021_01_06_425584 209 32 47 47 CD 10_1101-2021_01_06_425584 209 33 - - SYM 10_1101-2021_01_06_425584 209 34 53 53 CD 10_1101-2021_01_06_425584 209 35 ) ) -RRB- 10_1101-2021_01_06_425584 209 36 , , , 10_1101-2021_01_06_425584 209 37 399 399 CD 10_1101-2021_01_06_425584 209 38 accompanied accompany VBN 10_1101-2021_01_06_425584 209 39 by by IN 10_1101-2021_01_06_425584 209 40 an an DT 10_1101-2021_01_06_425584 209 41 increase increase NN 10_1101-2021_01_06_425584 209 42 in in IN 10_1101-2021_01_06_425584 209 43 protein protein NN 10_1101-2021_01_06_425584 209 44 synthesis synthesis NN 10_1101-2021_01_06_425584 209 45 ( ( -LRB- 10_1101-2021_01_06_425584 209 46 53 53 CD 10_1101-2021_01_06_425584 209 47 ) ) -RRB- 10_1101-2021_01_06_425584 209 48 . . . 10_1101-2021_01_06_425584 210 1 This this DT 10_1101-2021_01_06_425584 210 2 MS MS NNP 10_1101-2021_01_06_425584 210 3 - - HYPH 10_1101-2021_01_06_425584 210 4 based base VBN 10_1101-2021_01_06_425584 210 5 methodological methodological JJ 10_1101-2021_01_06_425584 210 6 pipeline pipeline NN 10_1101-2021_01_06_425584 210 7 400 400 CD 10_1101-2021_01_06_425584 210 8 that that WDT 10_1101-2021_01_06_425584 210 9 included include VBD 10_1101-2021_01_06_425584 210 10 appropriate appropriate JJ 10_1101-2021_01_06_425584 210 11 controls control NNS 10_1101-2021_01_06_425584 210 12 during during IN 10_1101-2021_01_06_425584 210 13 data datum NNS 10_1101-2021_01_06_425584 210 14 acquisition acquisition NN 10_1101-2021_01_06_425584 210 15 ( ( -LRB- 10_1101-2021_01_06_425584 210 16 QC QC NNP 10_1101-2021_01_06_425584 210 17 ) ) -RRB- 10_1101-2021_01_06_425584 210 18 and and CC 10_1101-2021_01_06_425584 210 19 processing processing NN 10_1101-2021_01_06_425584 210 20 ( ( -LRB- 10_1101-2021_01_06_425584 210 21 e.g. e.g. RB 10_1101-2021_01_06_425584 210 22 , , , 10_1101-2021_01_06_425584 210 23 401 401 CD 10_1101-2021_01_06_425584 210 24 normalization normalization NN 10_1101-2021_01_06_425584 210 25 , , , 10_1101-2021_01_06_425584 210 26 filtering filtering NN 10_1101-2021_01_06_425584 210 27 , , , 10_1101-2021_01_06_425584 210 28 annotation annotation NN 10_1101-2021_01_06_425584 210 29 , , , 10_1101-2021_01_06_425584 210 30 dereplication dereplication NN 10_1101-2021_01_06_425584 210 31 , , , 10_1101-2021_01_06_425584 210 32 etc etc FW 10_1101-2021_01_06_425584 210 33 . . . 10_1101-2021_01_06_425584 211 1 ) ) -RRB- 10_1101-2021_01_06_425584 211 2 , , , 10_1101-2021_01_06_425584 211 3 allowed allow VBD 10_1101-2021_01_06_425584 211 4 the the DT 10_1101-2021_01_06_425584 211 5 identification identification NN 10_1101-2021_01_06_425584 211 6 of of IN 10_1101-2021_01_06_425584 211 7 global global JJ 10_1101-2021_01_06_425584 211 8 402 402 CD 10_1101-2021_01_06_425584 211 9 changes change NNS 10_1101-2021_01_06_425584 211 10 in in IN 10_1101-2021_01_06_425584 211 11 the the DT 10_1101-2021_01_06_425584 211 12 metabolome metabolome NN 10_1101-2021_01_06_425584 211 13 of of IN 10_1101-2021_01_06_425584 211 14 CAEC caec NN 10_1101-2021_01_06_425584 211 15 under under IN 10_1101-2021_01_06_425584 211 16 HG HG NNP 10_1101-2021_01_06_425584 211 17 + + CC 10_1101-2021_01_06_425584 211 18 HI hi UH 10_1101-2021_01_06_425584 211 19 . . . 10_1101-2021_01_06_425584 212 1 Specifically specifically RB 10_1101-2021_01_06_425584 212 2 , , , 10_1101-2021_01_06_425584 212 3 increased increase VBN 10_1101-2021_01_06_425584 212 4 abundance abundance NN 10_1101-2021_01_06_425584 212 5 of of IN 10_1101-2021_01_06_425584 212 6 valine valine NN 10_1101-2021_01_06_425584 212 7 , , , 10_1101-2021_01_06_425584 212 8 403 403 CD 10_1101-2021_01_06_425584 212 9 leucine leucine NN 10_1101-2021_01_06_425584 212 10 , , , 10_1101-2021_01_06_425584 212 11 tyrosine tyrosine NN 10_1101-2021_01_06_425584 212 12 , , , 10_1101-2021_01_06_425584 212 13 serine serine NNP 10_1101-2021_01_06_425584 212 14 , , , 10_1101-2021_01_06_425584 212 15 leucine leucine NNP 10_1101-2021_01_06_425584 212 16 , , , 10_1101-2021_01_06_425584 212 17 proline proline NNP 10_1101-2021_01_06_425584 212 18 , , , 10_1101-2021_01_06_425584 212 19 methionine methionine NN 10_1101-2021_01_06_425584 212 20 , , , 10_1101-2021_01_06_425584 212 21 and and CC 10_1101-2021_01_06_425584 212 22 glutamic glutamic NN 10_1101-2021_01_06_425584 212 23 acid acid NN 10_1101-2021_01_06_425584 212 24 in in IN 10_1101-2021_01_06_425584 212 25 cells cell NNS 10_1101-2021_01_06_425584 212 26 under under IN 10_1101-2021_01_06_425584 212 27 HG HG NNP 10_1101-2021_01_06_425584 212 28 404 404 CD 10_1101-2021_01_06_425584 212 29 conditions condition NNS 10_1101-2021_01_06_425584 212 30 was be VBD 10_1101-2021_01_06_425584 212 31 observed observe VBN 10_1101-2021_01_06_425584 212 32 ; ; : 10_1101-2021_01_06_425584 212 33 and and CC 10_1101-2021_01_06_425584 212 34 this this DT 10_1101-2021_01_06_425584 212 35 is be VBZ 10_1101-2021_01_06_425584 212 36 consistent consistent JJ 10_1101-2021_01_06_425584 212 37 with with IN 10_1101-2021_01_06_425584 212 38 reports report NNS 10_1101-2021_01_06_425584 212 39 on on IN 10_1101-2021_01_06_425584 212 40 human human JJ 10_1101-2021_01_06_425584 212 41 aortic aortic JJ 10_1101-2021_01_06_425584 212 42 endothelial endothelial JJ 10_1101-2021_01_06_425584 212 43 cells cell NNS 10_1101-2021_01_06_425584 212 44 405 405 CD 10_1101-2021_01_06_425584 212 45 ( ( -LRB- 10_1101-2021_01_06_425584 212 46 54 54 CD 10_1101-2021_01_06_425584 212 47 ) ) -RRB- 10_1101-2021_01_06_425584 212 48 . . . 10_1101-2021_01_06_425584 213 1 Notably notably RB 10_1101-2021_01_06_425584 213 2 , , , 10_1101-2021_01_06_425584 213 3 several several JJ 10_1101-2021_01_06_425584 213 4 clinical clinical JJ 10_1101-2021_01_06_425584 213 5 studies study NNS 10_1101-2021_01_06_425584 213 6 have have VBP 10_1101-2021_01_06_425584 213 7 established establish VBN 10_1101-2021_01_06_425584 213 8 a a DT 10_1101-2021_01_06_425584 213 9 direct direct JJ 10_1101-2021_01_06_425584 213 10 relationship relationship NN 10_1101-2021_01_06_425584 213 11 between between IN 10_1101-2021_01_06_425584 213 12 406 406 CD 10_1101-2021_01_06_425584 213 13 prevalence prevalence NN 10_1101-2021_01_06_425584 213 14 / / SYM 10_1101-2021_01_06_425584 213 15 incidence incidence NN 10_1101-2021_01_06_425584 213 16 of of IN 10_1101-2021_01_06_425584 213 17 T2DM T2DM NNP 10_1101-2021_01_06_425584 213 18 and and CC 10_1101-2021_01_06_425584 213 19 increased increase VBN 10_1101-2021_01_06_425584 213 20 levels level NNS 10_1101-2021_01_06_425584 213 21 of of IN 10_1101-2021_01_06_425584 213 22 valine valine NN 10_1101-2021_01_06_425584 213 23 , , , 10_1101-2021_01_06_425584 213 24 leucine leucine NN 10_1101-2021_01_06_425584 213 25 and and CC 10_1101-2021_01_06_425584 213 26 tyrosine tyrosine NN 10_1101-2021_01_06_425584 213 27 in in IN 10_1101-2021_01_06_425584 213 28 serum serum NN 10_1101-2021_01_06_425584 213 29 and and CC 10_1101-2021_01_06_425584 213 30 407 407 CD 10_1101-2021_01_06_425584 213 31 plasma plasma NN 10_1101-2021_01_06_425584 213 32 ( ( -LRB- 10_1101-2021_01_06_425584 213 33 55 55 CD 10_1101-2021_01_06_425584 213 34 - - SYM 10_1101-2021_01_06_425584 213 35 59 59 CD 10_1101-2021_01_06_425584 213 36 ) ) -RRB- 10_1101-2021_01_06_425584 213 37 . . . 10_1101-2021_01_06_425584 214 1 Our -PRON- PRP$ 10_1101-2021_01_06_425584 214 2 results result NNS 10_1101-2021_01_06_425584 214 3 support support VBP 10_1101-2021_01_06_425584 214 4 the the DT 10_1101-2021_01_06_425584 214 5 role role NN 10_1101-2021_01_06_425584 214 6 of of IN 10_1101-2021_01_06_425584 214 7 CAEC caec NN 10_1101-2021_01_06_425584 214 8 in in IN 10_1101-2021_01_06_425584 214 9 contributing contribute VBG 10_1101-2021_01_06_425584 214 10 to to IN 10_1101-2021_01_06_425584 214 11 the the DT 10_1101-2021_01_06_425584 214 12 elevated elevated JJ 10_1101-2021_01_06_425584 214 13 pool pool NN 10_1101-2021_01_06_425584 214 14 of of IN 10_1101-2021_01_06_425584 214 15 amino amino JJ 10_1101-2021_01_06_425584 214 16 408 408 CD 10_1101-2021_01_06_425584 214 17 acids acid NNS 10_1101-2021_01_06_425584 214 18 seen see VBN 10_1101-2021_01_06_425584 214 19 in in IN 10_1101-2021_01_06_425584 214 20 circulation circulation NN 10_1101-2021_01_06_425584 214 21 under under IN 10_1101-2021_01_06_425584 214 22 a a DT 10_1101-2021_01_06_425584 214 23 HG HG NNP 10_1101-2021_01_06_425584 214 24 environment environment NN 10_1101-2021_01_06_425584 214 25 . . . 10_1101-2021_01_06_425584 215 1 We -PRON- PRP 10_1101-2021_01_06_425584 215 2 speculate speculate VBP 10_1101-2021_01_06_425584 215 3 that that IN 10_1101-2021_01_06_425584 215 4 increased increase VBN 10_1101-2021_01_06_425584 215 5 levels level NNS 10_1101-2021_01_06_425584 215 6 of of IN 10_1101-2021_01_06_425584 215 7 these these DT 10_1101-2021_01_06_425584 215 8 409 409 CD 10_1101-2021_01_06_425584 215 9 amino amino JJ 10_1101-2021_01_06_425584 215 10 acids acid NNS 10_1101-2021_01_06_425584 215 11 could could MD 10_1101-2021_01_06_425584 215 12 result result VB 10_1101-2021_01_06_425584 215 13 from from IN 10_1101-2021_01_06_425584 215 14 either either DT 10_1101-2021_01_06_425584 215 15 increased increase VBN 10_1101-2021_01_06_425584 215 16 production production NN 10_1101-2021_01_06_425584 215 17 or or CC 10_1101-2021_01_06_425584 215 18 reduced reduced JJ 10_1101-2021_01_06_425584 215 19 degradation degradation NN 10_1101-2021_01_06_425584 215 20 as as IN 10_1101-2021_01_06_425584 215 21 suggested suggest VBD 10_1101-2021_01_06_425584 215 22 410 410 CD 10_1101-2021_01_06_425584 215 23 in in IN 10_1101-2021_01_06_425584 215 24 endothelial endothelial JJ 10_1101-2021_01_06_425584 215 25 cells cell NNS 10_1101-2021_01_06_425584 215 26 ( ( -LRB- 10_1101-2021_01_06_425584 215 27 immortalized immortalize VBN 10_1101-2021_01_06_425584 215 28 cell cell NN 10_1101-2021_01_06_425584 215 29 line line NN 10_1101-2021_01_06_425584 215 30 , , , 10_1101-2021_01_06_425584 215 31 EA.hy EA.hy NNP 10_1101-2021_01_06_425584 215 32 926 926 CD 10_1101-2021_01_06_425584 215 33 ) ) -RRB- 10_1101-2021_01_06_425584 215 34 that that DT 10_1101-2021_01_06_425584 215 35 transition transition NN 10_1101-2021_01_06_425584 215 36 from from IN 10_1101-2021_01_06_425584 215 37 a a DT 10_1101-2021_01_06_425584 215 38 glycolytic glycolytic JJ 10_1101-2021_01_06_425584 215 39 metabolism metabolism NN 10_1101-2021_01_06_425584 215 40 411 411 CD 10_1101-2021_01_06_425584 215 41 towards towards IN 10_1101-2021_01_06_425584 215 42 lipid lipid NN 10_1101-2021_01_06_425584 215 43 and and CC 10_1101-2021_01_06_425584 215 44 amino amino JJ 10_1101-2021_01_06_425584 215 45 acid acid NN 10_1101-2021_01_06_425584 215 46 oxidation oxidation NN 10_1101-2021_01_06_425584 215 47 when when WRB 10_1101-2021_01_06_425584 215 48 challenged challenge VBN 10_1101-2021_01_06_425584 215 49 by by IN 10_1101-2021_01_06_425584 215 50 HG HG NNP 10_1101-2021_01_06_425584 215 51 ( ( -LRB- 10_1101-2021_01_06_425584 215 52 60 60 CD 10_1101-2021_01_06_425584 215 53 ) ) -RRB- 10_1101-2021_01_06_425584 215 54 . . . 10_1101-2021_01_06_425584 216 1 Furthermore furthermore RB 10_1101-2021_01_06_425584 216 2 , , , 10_1101-2021_01_06_425584 216 3 evidence evidence NN 10_1101-2021_01_06_425584 216 4 of of IN 10_1101-2021_01_06_425584 216 5 412 412 CD 10_1101-2021_01_06_425584 216 6 increased increase VBN 10_1101-2021_01_06_425584 216 7 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 216 8 catabolism catabolism NN 10_1101-2021_01_06_425584 216 9 was be VBD 10_1101-2021_01_06_425584 216 10 identified identify VBN 10_1101-2021_01_06_425584 216 11 through through IN 10_1101-2021_01_06_425584 216 12 the the DT 10_1101-2021_01_06_425584 216 13 kynurenine kynurenine NNP 10_1101-2021_01_06_425584 216 14 pathway pathway NN 10_1101-2021_01_06_425584 216 15 . . . 10_1101-2021_01_06_425584 217 1 In in IN 10_1101-2021_01_06_425584 217 2 this this DT 10_1101-2021_01_06_425584 217 3 regard regard NN 10_1101-2021_01_06_425584 217 4 , , , 10_1101-2021_01_06_425584 217 5 a a DT 10_1101-2021_01_06_425584 217 6 413 413 CD 10_1101-2021_01_06_425584 217 7 non non JJ 10_1101-2021_01_06_425584 217 8 - - JJ 10_1101-2021_01_06_425584 217 9 significant significant JJ 10_1101-2021_01_06_425584 217 10 decrease decrease NN 10_1101-2021_01_06_425584 217 11 of of IN 10_1101-2021_01_06_425584 217 12 ~ ~ NFP 10_1101-2021_01_06_425584 217 13 40 40 CD 10_1101-2021_01_06_425584 217 14 % % NN 10_1101-2021_01_06_425584 217 15 in in IN 10_1101-2021_01_06_425584 217 16 the the DT 10_1101-2021_01_06_425584 217 17 abundance abundance NN 10_1101-2021_01_06_425584 217 18 of of IN 10_1101-2021_01_06_425584 217 19 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 217 20 was be VBD 10_1101-2021_01_06_425584 217 21 detected detect VBN 10_1101-2021_01_06_425584 217 22 . . . 10_1101-2021_01_06_425584 218 1 However however RB 10_1101-2021_01_06_425584 218 2 , , , 10_1101-2021_01_06_425584 218 3 a a DT 10_1101-2021_01_06_425584 218 4 414 414 CD 10_1101-2021_01_06_425584 218 5 significant significant JJ 10_1101-2021_01_06_425584 218 6 increase increase NN 10_1101-2021_01_06_425584 218 7 of of IN 10_1101-2021_01_06_425584 218 8 ~ ~ NFP 10_1101-2021_01_06_425584 218 9 450 450 CD 10_1101-2021_01_06_425584 218 10 % % NN 10_1101-2021_01_06_425584 218 11 in in IN 10_1101-2021_01_06_425584 218 12 kynurenine kynurenine NNP 10_1101-2021_01_06_425584 218 13 ( ( -LRB- 10_1101-2021_01_06_425584 218 14 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 218 15 ’s ’s POS 10_1101-2021_01_06_425584 218 16 main main JJ 10_1101-2021_01_06_425584 218 17 metabolite metabolite NN 10_1101-2021_01_06_425584 218 18 ) ) -RRB- 10_1101-2021_01_06_425584 218 19 ( ( -LRB- 10_1101-2021_01_06_425584 218 20 61 61 CD 10_1101-2021_01_06_425584 218 21 ) ) -RRB- 10_1101-2021_01_06_425584 218 22 between between IN 10_1101-2021_01_06_425584 218 23 the the DT 10_1101-2021_01_06_425584 218 24 HG HG NNP 10_1101-2021_01_06_425584 218 25 415 415 CD 10_1101-2021_01_06_425584 218 26 + + CC 10_1101-2021_01_06_425584 218 27 HI HI NNP 10_1101-2021_01_06_425584 218 28 group group NN 10_1101-2021_01_06_425584 218 29 and and CC 10_1101-2021_01_06_425584 218 30 NG NG NNP 10_1101-2021_01_06_425584 218 31 group group NN 10_1101-2021_01_06_425584 218 32 was be VBD 10_1101-2021_01_06_425584 218 33 also also RB 10_1101-2021_01_06_425584 218 34 observed observe VBN 10_1101-2021_01_06_425584 218 35 , , , 10_1101-2021_01_06_425584 218 36 which which WDT 10_1101-2021_01_06_425584 218 37 is be VBZ 10_1101-2021_01_06_425584 218 38 a a DT 10_1101-2021_01_06_425584 218 39 key key JJ 10_1101-2021_01_06_425584 218 40 finding finding NN 10_1101-2021_01_06_425584 218 41 as as IN 10_1101-2021_01_06_425584 218 42 elevated elevated JJ 10_1101-2021_01_06_425584 218 43 plasma plasma NN 10_1101-2021_01_06_425584 218 44 levels level NNS 10_1101-2021_01_06_425584 218 45 of of IN 10_1101-2021_01_06_425584 218 46 416 416 CD 10_1101-2021_01_06_425584 218 47 kynurenine kynurenine NNS 10_1101-2021_01_06_425584 218 48 are be VBP 10_1101-2021_01_06_425584 218 49 known know VBN 10_1101-2021_01_06_425584 218 50 to to TO 10_1101-2021_01_06_425584 218 51 increase increase VB 10_1101-2021_01_06_425584 218 52 CVD CVD NNP 10_1101-2021_01_06_425584 218 53 risk risk NN 10_1101-2021_01_06_425584 218 54 ( ( -LRB- 10_1101-2021_01_06_425584 218 55 62 62 CD 10_1101-2021_01_06_425584 218 56 , , , 10_1101-2021_01_06_425584 218 57 63 63 CD 10_1101-2021_01_06_425584 218 58 ) ) -RRB- 10_1101-2021_01_06_425584 218 59 . . . 10_1101-2021_01_06_425584 219 1 This this DT 10_1101-2021_01_06_425584 219 2 novel novel JJ 10_1101-2021_01_06_425584 219 3 finding finding NN 10_1101-2021_01_06_425584 219 4 contributes contribute NNS 10_1101-2021_01_06_425584 219 5 to to IN 10_1101-2021_01_06_425584 219 6 expanding expand VBG 10_1101-2021_01_06_425584 219 7 417 417 CD 10_1101-2021_01_06_425584 219 8 the the DT 10_1101-2021_01_06_425584 219 9 understanding understanding NN 10_1101-2021_01_06_425584 219 10 of of IN 10_1101-2021_01_06_425584 219 11 amino amino JJ 10_1101-2021_01_06_425584 219 12 acid acid NN 10_1101-2021_01_06_425584 219 13 metabolism metabolism NN 10_1101-2021_01_06_425584 219 14 in in IN 10_1101-2021_01_06_425584 219 15 endothelial endothelial JJ 10_1101-2021_01_06_425584 219 16 cells cell NNS 10_1101-2021_01_06_425584 219 17 under under IN 10_1101-2021_01_06_425584 219 18 simulated simulated JJ 10_1101-2021_01_06_425584 219 19 diabetes diabete NNS 10_1101-2021_01_06_425584 219 20 . . . 10_1101-2021_01_06_425584 220 1 Acetyl Acetyl NNP 10_1101-2021_01_06_425584 220 2 418 418 CD 10_1101-2021_01_06_425584 220 3 serotonin serotonin NN 10_1101-2021_01_06_425584 220 4 and and CC 10_1101-2021_01_06_425584 220 5 melatonin melatonin NN 10_1101-2021_01_06_425584 220 6 which which WDT 10_1101-2021_01_06_425584 220 7 are be VBP 10_1101-2021_01_06_425584 220 8 components component NNS 10_1101-2021_01_06_425584 220 9 of of IN 10_1101-2021_01_06_425584 220 10 the the DT 10_1101-2021_01_06_425584 220 11 serotonin serotonin JJ 10_1101-2021_01_06_425584 220 12 pathway pathway NN 10_1101-2021_01_06_425584 220 13 that that WDT 10_1101-2021_01_06_425584 220 14 degrades degrade VBZ 10_1101-2021_01_06_425584 220 15 419 419 CD 10_1101-2021_01_06_425584 220 16 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 220 17 ( ( -LRB- 10_1101-2021_01_06_425584 220 18 64 64 CD 10_1101-2021_01_06_425584 220 19 ) ) -RRB- 10_1101-2021_01_06_425584 220 20 were be VBD 10_1101-2021_01_06_425584 220 21 also also RB 10_1101-2021_01_06_425584 220 22 detected detect VBN 10_1101-2021_01_06_425584 220 23 with with IN 10_1101-2021_01_06_425584 220 24 only only JJ 10_1101-2021_01_06_425584 220 25 minor minor JJ 10_1101-2021_01_06_425584 220 26 abundancy abundancy NN 10_1101-2021_01_06_425584 220 27 increases increase NNS 10_1101-2021_01_06_425584 220 28 ( ( -LRB- 10_1101-2021_01_06_425584 220 29 20 20 CD 10_1101-2021_01_06_425584 220 30 - - SYM 10_1101-2021_01_06_425584 220 31 30 30 CD 10_1101-2021_01_06_425584 220 32 % % NN 10_1101-2021_01_06_425584 220 33 ) ) -RRB- 10_1101-2021_01_06_425584 220 34 in in IN 10_1101-2021_01_06_425584 220 35 the the DT 10_1101-2021_01_06_425584 220 36 HG HG NNP 10_1101-2021_01_06_425584 220 37 + + CC 10_1101-2021_01_06_425584 220 38 420 420 CD 10_1101-2021_01_06_425584 220 39 HI HI NNP 10_1101-2021_01_06_425584 220 40 group group NN 10_1101-2021_01_06_425584 220 41 compared compare VBN 10_1101-2021_01_06_425584 220 42 to to IN 10_1101-2021_01_06_425584 220 43 control control NN 10_1101-2021_01_06_425584 220 44 . . . 10_1101-2021_01_06_425584 221 1 Differences difference NNS 10_1101-2021_01_06_425584 221 2 in in IN 10_1101-2021_01_06_425584 221 3 glutathione glutathione NN 10_1101-2021_01_06_425584 221 4 ( ( -LRB- 10_1101-2021_01_06_425584 221 5 cysteine cysteine JJ 10_1101-2021_01_06_425584 221 6 - - HYPH 10_1101-2021_01_06_425584 221 7 glutamic glutamic JJ 10_1101-2021_01_06_425584 221 8 acid acid NN 10_1101-2021_01_06_425584 221 9 - - HYPH 10_1101-2021_01_06_425584 221 10 glycine glycine NN 10_1101-2021_01_06_425584 221 11 , , , 10_1101-2021_01_06_425584 221 12 421 421 CD 10_1101-2021_01_06_425584 221 13 tripeptide tripeptide NN 10_1101-2021_01_06_425584 221 14 ) ) -RRB- 10_1101-2021_01_06_425584 221 15 metabolism metabolism NN 10_1101-2021_01_06_425584 221 16 in in IN 10_1101-2021_01_06_425584 221 17 CAEC caec NN 10_1101-2021_01_06_425584 221 18 were be VBD 10_1101-2021_01_06_425584 221 19 also also RB 10_1101-2021_01_06_425584 221 20 found find VBN 10_1101-2021_01_06_425584 221 21 , , , 10_1101-2021_01_06_425584 221 22 suggesting suggest VBG 10_1101-2021_01_06_425584 221 23 an an DT 10_1101-2021_01_06_425584 221 24 increased increase VBN 10_1101-2021_01_06_425584 221 25 response response NN 10_1101-2021_01_06_425584 221 26 to to IN 10_1101-2021_01_06_425584 221 27 oxidative oxidative JJ 10_1101-2021_01_06_425584 221 28 422 422 CD 10_1101-2021_01_06_425584 221 29 stress stress NN 10_1101-2021_01_06_425584 221 30 ( ( -LRB- 10_1101-2021_01_06_425584 221 31 65 65 CD 10_1101-2021_01_06_425584 221 32 ) ) -RRB- 10_1101-2021_01_06_425584 221 33 . . . 10_1101-2021_01_06_425584 222 1 In in IN 10_1101-2021_01_06_425584 222 2 line line NN 10_1101-2021_01_06_425584 222 3 with with IN 10_1101-2021_01_06_425584 222 4 this this DT 10_1101-2021_01_06_425584 222 5 observation observation NN 10_1101-2021_01_06_425584 222 6 , , , 10_1101-2021_01_06_425584 222 7 previous previous JJ 10_1101-2021_01_06_425584 222 8 research research NN 10_1101-2021_01_06_425584 222 9 reported report VBD 10_1101-2021_01_06_425584 222 10 a a DT 10_1101-2021_01_06_425584 222 11 glutathione glutathione NN 10_1101-2021_01_06_425584 222 12 - - HYPH 10_1101-2021_01_06_425584 222 13 dependent dependent JJ 10_1101-2021_01_06_425584 222 14 423 423 CD 10_1101-2021_01_06_425584 222 15 .CC .CC , 10_1101-2021_01_06_425584 222 16 - - HYPH 10_1101-2021_01_06_425584 222 17 BY by IN 10_1101-2021_01_06_425584 222 18 - - HYPH 10_1101-2021_01_06_425584 222 19 NC NC NNP 10_1101-2021_01_06_425584 222 20 - - HYPH 10_1101-2021_01_06_425584 222 21 ND ND NNP 10_1101-2021_01_06_425584 222 22 4.0 4.0 CD 10_1101-2021_01_06_425584 222 23 International International NNP 10_1101-2021_01_06_425584 222 24 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 222 25 under under IN 10_1101-2021_01_06_425584 222 26 a a DT 10_1101-2021_01_06_425584 222 27 ( ( -LRB- 10_1101-2021_01_06_425584 222 28 which which WDT 10_1101-2021_01_06_425584 222 29 was be VBD 10_1101-2021_01_06_425584 222 30 not not RB 10_1101-2021_01_06_425584 222 31 certified certify VBN 10_1101-2021_01_06_425584 222 32 by by IN 10_1101-2021_01_06_425584 222 33 peer peer NN 10_1101-2021_01_06_425584 222 34 review review NN 10_1101-2021_01_06_425584 222 35 ) ) -RRB- 10_1101-2021_01_06_425584 222 36 is be VBZ 10_1101-2021_01_06_425584 222 37 the the DT 10_1101-2021_01_06_425584 222 38 author author NN 10_1101-2021_01_06_425584 222 39 / / SYM 10_1101-2021_01_06_425584 222 40 funder funder NN 10_1101-2021_01_06_425584 222 41 , , , 10_1101-2021_01_06_425584 222 42 who who WP 10_1101-2021_01_06_425584 222 43 has have VBZ 10_1101-2021_01_06_425584 222 44 granted grant VBN 10_1101-2021_01_06_425584 222 45 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 222 46 a a DT 10_1101-2021_01_06_425584 222 47 license license NN 10_1101-2021_01_06_425584 222 48 to to TO 10_1101-2021_01_06_425584 222 49 display display VB 10_1101-2021_01_06_425584 222 50 the the DT 10_1101-2021_01_06_425584 222 51 preprint preprint NN 10_1101-2021_01_06_425584 222 52 in in IN 10_1101-2021_01_06_425584 222 53 perpetuity perpetuity NN 10_1101-2021_01_06_425584 222 54 . . . 10_1101-2021_01_06_425584 223 1 It -PRON- PRP 10_1101-2021_01_06_425584 223 2 is be VBZ 10_1101-2021_01_06_425584 223 3 made make VBN 10_1101-2021_01_06_425584 223 4 The the DT 10_1101-2021_01_06_425584 223 5 copyright copyright NN 10_1101-2021_01_06_425584 223 6 holder holder NN 10_1101-2021_01_06_425584 223 7 for for IN 10_1101-2021_01_06_425584 223 8 this this DT 10_1101-2021_01_06_425584 223 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 223 10 version version NN 10_1101-2021_01_06_425584 223 11 posted post VBD 10_1101-2021_01_06_425584 223 12 January January NNP 10_1101-2021_01_06_425584 223 13 8 8 CD 10_1101-2021_01_06_425584 223 14 , , , 10_1101-2021_01_06_425584 223 15 2021 2021 CD 10_1101-2021_01_06_425584 223 16 . . . 10_1101-2021_01_06_425584 223 17 ; ; : 10_1101-2021_01_06_425584 223 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 223 19 : : : 10_1101-2021_01_06_425584 223 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 223 21 preprint preprint NN 10_1101-2021_01_06_425584 223 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 223 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 223 24 14 14 CD 10_1101-2021_01_06_425584 223 25 reaction reaction NN 10_1101-2021_01_06_425584 223 26 to to TO 10_1101-2021_01_06_425584 223 27 ambient ambient JJ 10_1101-2021_01_06_425584 223 28 HG HG NNP 10_1101-2021_01_06_425584 223 29 in in IN 10_1101-2021_01_06_425584 223 30 artery artery NN 10_1101-2021_01_06_425584 223 31 - - HYPH 10_1101-2021_01_06_425584 223 32 derived derive VBN 10_1101-2021_01_06_425584 223 33 endothelial endothelial JJ 10_1101-2021_01_06_425584 223 34 cells cell NNS 10_1101-2021_01_06_425584 223 35 ( ( -LRB- 10_1101-2021_01_06_425584 223 36 66 66 CD 10_1101-2021_01_06_425584 223 37 , , , 10_1101-2021_01_06_425584 223 38 67 67 CD 10_1101-2021_01_06_425584 223 39 ) ) -RRB- 10_1101-2021_01_06_425584 223 40 but but CC 10_1101-2021_01_06_425584 223 41 the the DT 10_1101-2021_01_06_425584 223 42 same same JJ 10_1101-2021_01_06_425584 223 43 could could MD 10_1101-2021_01_06_425584 223 44 not not RB 10_1101-2021_01_06_425584 223 45 be be VB 10_1101-2021_01_06_425584 223 46 424 424 CD 10_1101-2021_01_06_425584 223 47 observed observe VBN 10_1101-2021_01_06_425584 223 48 in in IN 10_1101-2021_01_06_425584 223 49 vein vein NN 10_1101-2021_01_06_425584 223 50 - - HYPH 10_1101-2021_01_06_425584 223 51 derived derive VBN 10_1101-2021_01_06_425584 223 52 endothelial endothelial JJ 10_1101-2021_01_06_425584 223 53 cells cell NNS 10_1101-2021_01_06_425584 223 54 ( ( -LRB- 10_1101-2021_01_06_425584 223 55 68 68 CD 10_1101-2021_01_06_425584 223 56 , , , 10_1101-2021_01_06_425584 223 57 69 69 CD 10_1101-2021_01_06_425584 223 58 ) ) -RRB- 10_1101-2021_01_06_425584 223 59 . . . 10_1101-2021_01_06_425584 224 1 This this DT 10_1101-2021_01_06_425584 224 2 emphasizes emphasize VBZ 10_1101-2021_01_06_425584 224 3 the the DT 10_1101-2021_01_06_425584 224 4 different different JJ 10_1101-2021_01_06_425584 224 5 responses response NNS 10_1101-2021_01_06_425584 224 6 to to IN 10_1101-2021_01_06_425584 224 7 425 425 CD 10_1101-2021_01_06_425584 224 8 HG HG NNP 10_1101-2021_01_06_425584 224 9 among among IN 10_1101-2021_01_06_425584 224 10 endothelial endothelial JJ 10_1101-2021_01_06_425584 224 11 phenotypes phenotype NNS 10_1101-2021_01_06_425584 224 12 . . . 10_1101-2021_01_06_425584 225 1 Here here RB 10_1101-2021_01_06_425584 225 2 , , , 10_1101-2021_01_06_425584 225 3 novel novel JJ 10_1101-2021_01_06_425584 225 4 evidence evidence NN 10_1101-2021_01_06_425584 225 5 is be VBZ 10_1101-2021_01_06_425584 225 6 provided provide VBN 10_1101-2021_01_06_425584 225 7 of of IN 10_1101-2021_01_06_425584 225 8 the the DT 10_1101-2021_01_06_425584 225 9 up up JJ 10_1101-2021_01_06_425584 225 10 - - HYPH 10_1101-2021_01_06_425584 225 11 regulation regulation NN 10_1101-2021_01_06_425584 225 12 of of IN 10_1101-2021_01_06_425584 225 13 426 426 CD 10_1101-2021_01_06_425584 225 14 glutathione glutathione NN 10_1101-2021_01_06_425584 225 15 - - HYPH 10_1101-2021_01_06_425584 225 16 based base VBN 10_1101-2021_01_06_425584 225 17 metabolites metabolite NNS 10_1101-2021_01_06_425584 225 18 . . . 10_1101-2021_01_06_425584 226 1 The the DT 10_1101-2021_01_06_425584 226 2 composite composite JJ 10_1101-2021_01_06_425584 226 3 protein protein NN 10_1101-2021_01_06_425584 226 4 network network NN 10_1101-2021_01_06_425584 226 5 suggested suggest VBD 10_1101-2021_01_06_425584 226 6 an an DT 10_1101-2021_01_06_425584 226 7 increase increase NN 10_1101-2021_01_06_425584 226 8 in in IN 10_1101-2021_01_06_425584 226 9 427 427 CD 10_1101-2021_01_06_425584 226 10 glutathione glutathione NN 10_1101-2021_01_06_425584 226 11 metabolism metabolism NN 10_1101-2021_01_06_425584 226 12 supported support VBN 10_1101-2021_01_06_425584 226 13 by by IN 10_1101-2021_01_06_425584 226 14 elevated elevated JJ 10_1101-2021_01_06_425584 226 15 levels level NNS 10_1101-2021_01_06_425584 226 16 of of IN 10_1101-2021_01_06_425584 226 17 oxidized oxidized JJ 10_1101-2021_01_06_425584 226 18 glutathione glutathione NN 10_1101-2021_01_06_425584 226 19 and and CC 10_1101-2021_01_06_425584 226 20 , , , 10_1101-2021_01_06_425584 226 21 one one CD 10_1101-2021_01_06_425584 226 22 of of IN 10_1101-2021_01_06_425584 226 23 its -PRON- PRP$ 10_1101-2021_01_06_425584 226 24 428 428 CD 10_1101-2021_01_06_425584 226 25 synthetic synthetic JJ 10_1101-2021_01_06_425584 226 26 precursors precursor NNS 10_1101-2021_01_06_425584 226 27 , , , 10_1101-2021_01_06_425584 226 28 glutamic glutamic JJ 10_1101-2021_01_06_425584 226 29 acid acid NN 10_1101-2021_01_06_425584 226 30 . . . 10_1101-2021_01_06_425584 227 1 At at IN 10_1101-2021_01_06_425584 227 2 the the DT 10_1101-2021_01_06_425584 227 3 protein protein NN 10_1101-2021_01_06_425584 227 4 level level NN 10_1101-2021_01_06_425584 227 5 , , , 10_1101-2021_01_06_425584 227 6 peroxiredoxin peroxiredoxin NN 10_1101-2021_01_06_425584 227 7 ( ( -LRB- 10_1101-2021_01_06_425584 227 8 PRDX2 PRDX2 NNS 10_1101-2021_01_06_425584 227 9 and and CC 10_1101-2021_01_06_425584 227 10 PRDX6 prdx6 NN 10_1101-2021_01_06_425584 227 11 ) ) -RRB- 10_1101-2021_01_06_425584 227 12 and and CC 10_1101-2021_01_06_425584 227 13 429 429 CD 10_1101-2021_01_06_425584 227 14 thioredoxin thioredoxin NN 10_1101-2021_01_06_425584 227 15 ( ( -LRB- 10_1101-2021_01_06_425584 227 16 TXN2 txn2 UH 10_1101-2021_01_06_425584 227 17 , , , 10_1101-2021_01_06_425584 227 18 mitochondrial mitochondrial NN 10_1101-2021_01_06_425584 227 19 ) ) -RRB- 10_1101-2021_01_06_425584 227 20 showed show VBD 10_1101-2021_01_06_425584 227 21 increased increase VBN 10_1101-2021_01_06_425584 227 22 abundances abundance NNS 10_1101-2021_01_06_425584 227 23 in in IN 10_1101-2021_01_06_425584 227 24 the the DT 10_1101-2021_01_06_425584 227 25 experimental experimental JJ 10_1101-2021_01_06_425584 227 26 group group NN 10_1101-2021_01_06_425584 227 27 , , , 10_1101-2021_01_06_425584 227 28 430 430 CD 10_1101-2021_01_06_425584 227 29 which which WDT 10_1101-2021_01_06_425584 227 30 are be VBP 10_1101-2021_01_06_425584 227 31 part part NN 10_1101-2021_01_06_425584 227 32 of of IN 10_1101-2021_01_06_425584 227 33 the the DT 10_1101-2021_01_06_425584 227 34 cells cell NNS 10_1101-2021_01_06_425584 227 35 natural natural JJ 10_1101-2021_01_06_425584 227 36 enzymatic enzymatic JJ 10_1101-2021_01_06_425584 227 37 defense defense NN 10_1101-2021_01_06_425584 227 38 against against IN 10_1101-2021_01_06_425584 227 39 oxidative oxidative JJ 10_1101-2021_01_06_425584 227 40 stress stress NN 10_1101-2021_01_06_425584 227 41 ( ( -LRB- 10_1101-2021_01_06_425584 227 42 70 70 CD 10_1101-2021_01_06_425584 227 43 ) ) -RRB- 10_1101-2021_01_06_425584 227 44 . . . 10_1101-2021_01_06_425584 228 1 The the DT 10_1101-2021_01_06_425584 228 2 431 431 CD 10_1101-2021_01_06_425584 228 3 substructure substructure NN 10_1101-2021_01_06_425584 228 4 analysis analysis NN 10_1101-2021_01_06_425584 228 5 of of IN 10_1101-2021_01_06_425584 228 6 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 228 7 data datum NNS 10_1101-2021_01_06_425584 228 8 facilitated facilitate VBN 10_1101-2021_01_06_425584 228 9 identifying identify VBG 10_1101-2021_01_06_425584 228 10 glutamic glutamic NNP 10_1101-2021_01_06_425584 228 11 acid- acid- NNP 10_1101-2021_01_06_425584 228 12 and and CC 10_1101-2021_01_06_425584 228 13 432 432 CD 10_1101-2021_01_06_425584 228 14 phenylalanine phenylalanine NN 10_1101-2021_01_06_425584 228 15 - - HYPH 10_1101-2021_01_06_425584 228 16 based base VBN 10_1101-2021_01_06_425584 228 17 metabolites metabolite NNS 10_1101-2021_01_06_425584 228 18 , , , 10_1101-2021_01_06_425584 228 19 presumably presumably RB 10_1101-2021_01_06_425584 228 20 di- di- NNP 10_1101-2021_01_06_425584 228 21 or or CC 10_1101-2021_01_06_425584 228 22 tri tri NNS 10_1101-2021_01_06_425584 228 23 - - NNS 10_1101-2021_01_06_425584 228 24 peptides peptide NNS 10_1101-2021_01_06_425584 228 25 , , , 10_1101-2021_01_06_425584 228 26 including include VBG 10_1101-2021_01_06_425584 228 27 the the DT 10_1101-2021_01_06_425584 228 28 annotated annotate VBN 10_1101-2021_01_06_425584 228 29 433 433 CD 10_1101-2021_01_06_425584 228 30 metabolite metabolite NNP 10_1101-2021_01_06_425584 228 31 glutamyl glutamyl NNP 10_1101-2021_01_06_425584 228 32 - - HYPH 10_1101-2021_01_06_425584 228 33 phenylalanine phenylalanine NNP 10_1101-2021_01_06_425584 228 34 . . . 10_1101-2021_01_06_425584 229 1 Furthermore furthermore RB 10_1101-2021_01_06_425584 229 2 , , , 10_1101-2021_01_06_425584 229 3 the the DT 10_1101-2021_01_06_425584 229 4 CAEC caec NN 10_1101-2021_01_06_425584 229 5 peptidome peptidome VBP 10_1101-2021_01_06_425584 229 6 analysis analysis NN 10_1101-2021_01_06_425584 229 7 suggested suggest VBD 10_1101-2021_01_06_425584 229 8 an an DT 10_1101-2021_01_06_425584 229 9 434 434 CD 10_1101-2021_01_06_425584 229 10 increase increase NN 10_1101-2021_01_06_425584 229 11 in in IN 10_1101-2021_01_06_425584 229 12 proline proline NN 10_1101-2021_01_06_425584 229 13 - - HYPH 10_1101-2021_01_06_425584 229 14 containing contain VBG 10_1101-2021_01_06_425584 229 15 peptides peptide NNS 10_1101-2021_01_06_425584 229 16 . . . 10_1101-2021_01_06_425584 230 1 This this DT 10_1101-2021_01_06_425584 230 2 type type NN 10_1101-2021_01_06_425584 230 3 of of IN 10_1101-2021_01_06_425584 230 4 peptide peptide NN 10_1101-2021_01_06_425584 230 5 is be VBZ 10_1101-2021_01_06_425584 230 6 of of IN 10_1101-2021_01_06_425584 230 7 particular particular JJ 10_1101-2021_01_06_425584 230 8 interest interest NN 10_1101-2021_01_06_425584 230 9 because because IN 10_1101-2021_01_06_425584 230 10 of of IN 10_1101-2021_01_06_425584 230 11 435 435 CD 10_1101-2021_01_06_425584 230 12 their -PRON- PRP$ 10_1101-2021_01_06_425584 230 13 resistance resistance NN 10_1101-2021_01_06_425584 230 14 to to IN 10_1101-2021_01_06_425584 230 15 non non JJ 10_1101-2021_01_06_425584 230 16 - - JJ 10_1101-2021_01_06_425584 230 17 specific specific JJ 10_1101-2021_01_06_425584 230 18 proteolytic proteolytic JJ 10_1101-2021_01_06_425584 230 19 degradation degradation NN 10_1101-2021_01_06_425584 230 20 , , , 10_1101-2021_01_06_425584 230 21 body body NN 10_1101-2021_01_06_425584 230 22 distribution distribution NN 10_1101-2021_01_06_425584 230 23 and and CC 10_1101-2021_01_06_425584 230 24 remarkable remarkable JJ 10_1101-2021_01_06_425584 230 25 436 436 CD 10_1101-2021_01_06_425584 230 26 biological biological JJ 10_1101-2021_01_06_425584 230 27 effects effect NNS 10_1101-2021_01_06_425584 230 28 ( ( -LRB- 10_1101-2021_01_06_425584 230 29 71 71 CD 10_1101-2021_01_06_425584 230 30 - - SYM 10_1101-2021_01_06_425584 230 31 74 74 CD 10_1101-2021_01_06_425584 230 32 ) ) -RRB- 10_1101-2021_01_06_425584 230 33 . . . 10_1101-2021_01_06_425584 231 1 Yet yet RB 10_1101-2021_01_06_425584 231 2 , , , 10_1101-2021_01_06_425584 231 3 the the DT 10_1101-2021_01_06_425584 231 4 precise precise JJ 10_1101-2021_01_06_425584 231 5 function function NN 10_1101-2021_01_06_425584 231 6 of of IN 10_1101-2021_01_06_425584 231 7 such such JJ 10_1101-2021_01_06_425584 231 8 phenylalanine- phenylalanine- NN 10_1101-2021_01_06_425584 231 9 , , , 10_1101-2021_01_06_425584 231 10 glutamine- glutamine- NNP 10_1101-2021_01_06_425584 231 11 , , , 10_1101-2021_01_06_425584 231 12 and and CC 10_1101-2021_01_06_425584 231 13 437 437 CD 10_1101-2021_01_06_425584 231 14 proline proline NN 10_1101-2021_01_06_425584 231 15 - - HYPH 10_1101-2021_01_06_425584 231 16 based base VBN 10_1101-2021_01_06_425584 231 17 peptides peptide NNS 10_1101-2021_01_06_425584 231 18 remains remain VBZ 10_1101-2021_01_06_425584 231 19 to to TO 10_1101-2021_01_06_425584 231 20 be be VB 10_1101-2021_01_06_425584 231 21 characterized characterize VBN 10_1101-2021_01_06_425584 231 22 in in IN 10_1101-2021_01_06_425584 231 23 CAEC caec NN 10_1101-2021_01_06_425584 231 24 . . . 10_1101-2021_01_06_425584 232 1 We -PRON- PRP 10_1101-2021_01_06_425584 232 2 can can MD 10_1101-2021_01_06_425584 232 3 only only RB 10_1101-2021_01_06_425584 232 4 speculate speculate VB 10_1101-2021_01_06_425584 232 5 that that IN 10_1101-2021_01_06_425584 232 6 they -PRON- PRP 10_1101-2021_01_06_425584 232 7 438 438 CD 10_1101-2021_01_06_425584 232 8 are be VBP 10_1101-2021_01_06_425584 232 9 the the DT 10_1101-2021_01_06_425584 232 10 result result NN 10_1101-2021_01_06_425584 232 11 of of IN 10_1101-2021_01_06_425584 232 12 a a DT 10_1101-2021_01_06_425584 232 13 compensatory compensatory JJ 10_1101-2021_01_06_425584 232 14 mechanism mechanism NN 10_1101-2021_01_06_425584 232 15 to to TO 10_1101-2021_01_06_425584 232 16 reduce reduce VB 10_1101-2021_01_06_425584 232 17 glucose glucose NN 10_1101-2021_01_06_425584 232 18 cellular cellular JJ 10_1101-2021_01_06_425584 232 19 damage damage NN 10_1101-2021_01_06_425584 232 20 . . . 10_1101-2021_01_06_425584 233 1 Also also RB 10_1101-2021_01_06_425584 233 2 , , , 10_1101-2021_01_06_425584 233 3 increased increase VBD 10_1101-2021_01_06_425584 233 4 439 439 CD 10_1101-2021_01_06_425584 233 5 protein protein NN 10_1101-2021_01_06_425584 233 6 abundance abundance NN 10_1101-2021_01_06_425584 233 7 of of IN 10_1101-2021_01_06_425584 233 8 core core JJ 10_1101-2021_01_06_425584 233 9 and and CC 10_1101-2021_01_06_425584 233 10 regulatory regulatory JJ 10_1101-2021_01_06_425584 233 11 subunits subunit NNS 10_1101-2021_01_06_425584 233 12 from from IN 10_1101-2021_01_06_425584 233 13 the the DT 10_1101-2021_01_06_425584 233 14 proteasome proteasome JJ 10_1101-2021_01_06_425584 233 15 complex complex NN 10_1101-2021_01_06_425584 233 16 ( ( -LRB- 10_1101-2021_01_06_425584 233 17 PSMA4 psma4 NN 10_1101-2021_01_06_425584 233 18 and and CC 10_1101-2021_01_06_425584 233 19 440 440 CD 10_1101-2021_01_06_425584 233 20 PSMD3 PSMD3 NNP 10_1101-2021_01_06_425584 233 21 ) ) -RRB- 10_1101-2021_01_06_425584 233 22 was be VBD 10_1101-2021_01_06_425584 233 23 found find VBN 10_1101-2021_01_06_425584 233 24 in in IN 10_1101-2021_01_06_425584 233 25 cells cell NNS 10_1101-2021_01_06_425584 233 26 under under IN 10_1101-2021_01_06_425584 233 27 simulated simulated JJ 10_1101-2021_01_06_425584 233 28 diabetes diabete NNS 10_1101-2021_01_06_425584 233 29 . . . 10_1101-2021_01_06_425584 234 1 This this DT 10_1101-2021_01_06_425584 234 2 suggests suggest VBZ 10_1101-2021_01_06_425584 234 3 an an DT 10_1101-2021_01_06_425584 234 4 increased increased JJ 10_1101-2021_01_06_425584 234 5 protein protein NN 10_1101-2021_01_06_425584 234 6 441 441 CD 10_1101-2021_01_06_425584 234 7 degradation degradation NN 10_1101-2021_01_06_425584 234 8 and and CC 10_1101-2021_01_06_425584 234 9 subsequent subsequent JJ 10_1101-2021_01_06_425584 234 10 peptide peptide NN 10_1101-2021_01_06_425584 234 11 formation formation NN 10_1101-2021_01_06_425584 234 12 in in IN 10_1101-2021_01_06_425584 234 13 response response NN 10_1101-2021_01_06_425584 234 14 to to IN 10_1101-2021_01_06_425584 234 15 HG HG NNP 10_1101-2021_01_06_425584 234 16 . . . 10_1101-2021_01_06_425584 235 1 Metabolomic metabolomic JJ 10_1101-2021_01_06_425584 235 2 profiling profiling NN 10_1101-2021_01_06_425584 235 3 also also RB 10_1101-2021_01_06_425584 235 4 442 442 CD 10_1101-2021_01_06_425584 235 5 revealed reveal VBD 10_1101-2021_01_06_425584 235 6 changes change NNS 10_1101-2021_01_06_425584 235 7 in in IN 10_1101-2021_01_06_425584 235 8 the the DT 10_1101-2021_01_06_425584 235 9 lipidome lipidome NN 10_1101-2021_01_06_425584 235 10 of of IN 10_1101-2021_01_06_425584 235 11 CAEC caec NN 10_1101-2021_01_06_425584 235 12 challenged challenge VBN 10_1101-2021_01_06_425584 235 13 with with IN 10_1101-2021_01_06_425584 235 14 HG HG NNP 10_1101-2021_01_06_425584 235 15 + + CC 10_1101-2021_01_06_425584 235 16 HI hi UH 10_1101-2021_01_06_425584 235 17 , , , 10_1101-2021_01_06_425584 235 18 wherein wherein WRB 10_1101-2021_01_06_425584 235 19 a a DT 10_1101-2021_01_06_425584 235 20 reduction reduction NN 10_1101-2021_01_06_425584 235 21 in in IN 10_1101-2021_01_06_425584 235 22 443 443 CD 10_1101-2021_01_06_425584 235 23 phosphatidylcholine phosphatidylcholine NN 10_1101-2021_01_06_425584 235 24 ( ( -LRB- 10_1101-2021_01_06_425584 235 25 PC PC NNP 10_1101-2021_01_06_425584 235 26 ) ) -RRB- 10_1101-2021_01_06_425584 235 27 lipids lipid NNS 10_1101-2021_01_06_425584 235 28 and and CC 10_1101-2021_01_06_425584 235 29 subsequent subsequent JJ 10_1101-2021_01_06_425584 235 30 increase increase NN 10_1101-2021_01_06_425584 235 31 in in IN 10_1101-2021_01_06_425584 235 32 phosphocholine phosphocholine NN 10_1101-2021_01_06_425584 235 33 were be VBD 10_1101-2021_01_06_425584 235 34 noted note VBN 10_1101-2021_01_06_425584 235 35 . . . 10_1101-2021_01_06_425584 236 1 444 444 CD 10_1101-2021_01_06_425584 236 2 Changes change NNS 10_1101-2021_01_06_425584 236 3 in in IN 10_1101-2021_01_06_425584 236 4 the the DT 10_1101-2021_01_06_425584 236 5 phospholipidomic phospholipidomic JJ 10_1101-2021_01_06_425584 236 6 profile profile NN 10_1101-2021_01_06_425584 236 7 of of IN 10_1101-2021_01_06_425584 236 8 bovine bovine JJ 10_1101-2021_01_06_425584 236 9 aortic aortic JJ 10_1101-2021_01_06_425584 236 10 endothelial endothelial JJ 10_1101-2021_01_06_425584 236 11 cells cell NNS 10_1101-2021_01_06_425584 236 12 treated treat VBN 10_1101-2021_01_06_425584 236 13 with with IN 10_1101-2021_01_06_425584 236 14 HG HG NNP 10_1101-2021_01_06_425584 236 15 for for IN 10_1101-2021_01_06_425584 236 16 24 24 CD 10_1101-2021_01_06_425584 236 17 445 445 CD 10_1101-2021_01_06_425584 236 18 h h NN 10_1101-2021_01_06_425584 236 19 has have VBZ 10_1101-2021_01_06_425584 236 20 also also RB 10_1101-2021_01_06_425584 236 21 been be VBN 10_1101-2021_01_06_425584 236 22 reported report VBN 10_1101-2021_01_06_425584 236 23 in in IN 10_1101-2021_01_06_425584 236 24 a a DT 10_1101-2021_01_06_425584 236 25 lipidome lipidome JJ 10_1101-2021_01_06_425584 236 26 study study NN 10_1101-2021_01_06_425584 236 27 ( ( -LRB- 10_1101-2021_01_06_425584 236 28 75 75 CD 10_1101-2021_01_06_425584 236 29 ) ) -RRB- 10_1101-2021_01_06_425584 236 30 . . . 10_1101-2021_01_06_425584 237 1 Here here RB 10_1101-2021_01_06_425584 237 2 , , , 10_1101-2021_01_06_425584 237 3 proteomics proteomic NNS 10_1101-2021_01_06_425584 237 4 and and CC 10_1101-2021_01_06_425584 237 5 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 237 6 data datum NNS 10_1101-2021_01_06_425584 237 7 were be VBD 10_1101-2021_01_06_425584 237 8 446 446 CD 10_1101-2021_01_06_425584 237 9 manually manually RB 10_1101-2021_01_06_425584 237 10 integrated integrate VBN 10_1101-2021_01_06_425584 237 11 and and CC 10_1101-2021_01_06_425584 237 12 this this DT 10_1101-2021_01_06_425584 237 13 allowed allow VBD 10_1101-2021_01_06_425584 237 14 to to TO 10_1101-2021_01_06_425584 237 15 determine determine VB 10_1101-2021_01_06_425584 237 16 critical critical JJ 10_1101-2021_01_06_425584 237 17 roles role NNS 10_1101-2021_01_06_425584 237 18 for for IN 10_1101-2021_01_06_425584 237 19 PAFAH1B2 PAFAH1B2 NNP 10_1101-2021_01_06_425584 237 20 and and CC 10_1101-2021_01_06_425584 237 21 LYPLA1 LYPLA1 `` 10_1101-2021_01_06_425584 237 22 in in IN 10_1101-2021_01_06_425584 237 23 447 447 CD 10_1101-2021_01_06_425584 237 24 mediating mediate VBG 10_1101-2021_01_06_425584 237 25 the the DT 10_1101-2021_01_06_425584 237 26 degradation degradation NN 10_1101-2021_01_06_425584 237 27 of of IN 10_1101-2021_01_06_425584 237 28 PC pc NN 10_1101-2021_01_06_425584 237 29 lipids lipid NNS 10_1101-2021_01_06_425584 237 30 ( ( -LRB- 10_1101-2021_01_06_425584 237 31 Figure figure NN 10_1101-2021_01_06_425584 237 32 8) 8) CD 10_1101-2021_01_06_425584 237 33 . . . 10_1101-2021_01_06_425584 238 1 PAFAH1B2 PAFAH1B2 NNP 10_1101-2021_01_06_425584 238 2 was be VBD 10_1101-2021_01_06_425584 238 3 found find VBN 10_1101-2021_01_06_425584 238 4 to to TO 10_1101-2021_01_06_425584 238 5 be be VB 10_1101-2021_01_06_425584 238 6 up up RB 10_1101-2021_01_06_425584 238 7 - - HYPH 10_1101-2021_01_06_425584 238 8 regulated regulated JJ 10_1101-2021_01_06_425584 238 9 in in IN 10_1101-2021_01_06_425584 238 10 448 448 CD 10_1101-2021_01_06_425584 238 11 this this DT 10_1101-2021_01_06_425584 238 12 study study NN 10_1101-2021_01_06_425584 238 13 and and CC 10_1101-2021_01_06_425584 238 14 it -PRON- PRP 10_1101-2021_01_06_425584 238 15 is be VBZ 10_1101-2021_01_06_425584 238 16 known know VBN 10_1101-2021_01_06_425584 238 17 to to TO 10_1101-2021_01_06_425584 238 18 be be VB 10_1101-2021_01_06_425584 238 19 associated associate VBN 10_1101-2021_01_06_425584 238 20 with with IN 10_1101-2021_01_06_425584 238 21 inflammation inflammation NN 10_1101-2021_01_06_425584 238 22 and and CC 10_1101-2021_01_06_425584 238 23 higher high JJR 10_1101-2021_01_06_425584 238 24 levels level NNS 10_1101-2021_01_06_425584 238 25 of of IN 10_1101-2021_01_06_425584 238 26 lysoPC lysoPC NNP 10_1101-2021_01_06_425584 238 27 ( ( -LRB- 10_1101-2021_01_06_425584 238 28 76 76 CD 10_1101-2021_01_06_425584 238 29 ) ) -RRB- 10_1101-2021_01_06_425584 238 30 . . . 10_1101-2021_01_06_425584 239 1 As as IN 10_1101-2021_01_06_425584 239 2 449 449 CD 10_1101-2021_01_06_425584 239 3 a a DT 10_1101-2021_01_06_425584 239 4 result result NN 10_1101-2021_01_06_425584 239 5 , , , 10_1101-2021_01_06_425584 239 6 PAFAH1B2 PAFAH1B2 NNP 10_1101-2021_01_06_425584 239 7 could could MD 10_1101-2021_01_06_425584 239 8 increase increase VB 10_1101-2021_01_06_425584 239 9 the the DT 10_1101-2021_01_06_425584 239 10 pool pool NN 10_1101-2021_01_06_425584 239 11 of of IN 10_1101-2021_01_06_425584 239 12 lysoPC lysoPC NNP 10_1101-2021_01_06_425584 239 13 lipids lipid NNS 10_1101-2021_01_06_425584 239 14 , , , 10_1101-2021_01_06_425584 239 15 further further RB 10_1101-2021_01_06_425584 239 16 exacerbating exacerbate VBG 10_1101-2021_01_06_425584 239 17 inflammation inflammation NN 10_1101-2021_01_06_425584 239 18 450 450 CD 10_1101-2021_01_06_425584 239 19 in in IN 10_1101-2021_01_06_425584 239 20 the the DT 10_1101-2021_01_06_425584 239 21 cardiovascular cardiovascular JJ 10_1101-2021_01_06_425584 239 22 system system NN 10_1101-2021_01_06_425584 239 23 ( ( -LRB- 10_1101-2021_01_06_425584 239 24 77 77 CD 10_1101-2021_01_06_425584 239 25 ) ) -RRB- 10_1101-2021_01_06_425584 239 26 . . . 10_1101-2021_01_06_425584 240 1 On on IN 10_1101-2021_01_06_425584 240 2 the the DT 10_1101-2021_01_06_425584 240 3 other other JJ 10_1101-2021_01_06_425584 240 4 hand hand NN 10_1101-2021_01_06_425584 240 5 , , , 10_1101-2021_01_06_425584 240 6 LYPLA1 LYPLA1 NNP 10_1101-2021_01_06_425584 240 7 has have VBZ 10_1101-2021_01_06_425584 240 8 a a DT 10_1101-2021_01_06_425584 240 9 lysophospholipase lysophospholipase NN 10_1101-2021_01_06_425584 240 10 activity activity NN 10_1101-2021_01_06_425584 240 11 451 451 CD 10_1101-2021_01_06_425584 240 12 that that WDT 10_1101-2021_01_06_425584 240 13 can can MD 10_1101-2021_01_06_425584 240 14 hydrolyze hydrolyze VB 10_1101-2021_01_06_425584 240 15 a a DT 10_1101-2021_01_06_425584 240 16 range range NN 10_1101-2021_01_06_425584 240 17 of of IN 10_1101-2021_01_06_425584 240 18 lysophospholipids lysophospholipid NNS 10_1101-2021_01_06_425584 240 19 , , , 10_1101-2021_01_06_425584 240 20 including include VBG 10_1101-2021_01_06_425584 240 21 LysoPC LysoPC NNP 10_1101-2021_01_06_425584 240 22 , , , 10_1101-2021_01_06_425584 240 23 thereby thereby RB 10_1101-2021_01_06_425584 240 24 generating generate VBG 10_1101-2021_01_06_425584 240 25 a a DT 10_1101-2021_01_06_425584 240 26 fatty fatty NN 10_1101-2021_01_06_425584 240 27 452 452 CD 10_1101-2021_01_06_425584 240 28 acid acid NN 10_1101-2021_01_06_425584 240 29 and and CC 10_1101-2021_01_06_425584 240 30 glycerophosphocholine glycerophosphocholine NN 10_1101-2021_01_06_425584 240 31 as as IN 10_1101-2021_01_06_425584 240 32 products product NNS 10_1101-2021_01_06_425584 240 33 ( ( -LRB- 10_1101-2021_01_06_425584 240 34 78 78 CD 10_1101-2021_01_06_425584 240 35 ) ) -RRB- 10_1101-2021_01_06_425584 240 36 . . . 10_1101-2021_01_06_425584 241 1 Increased increased JJ 10_1101-2021_01_06_425584 241 2 levels level NNS 10_1101-2021_01_06_425584 241 3 of of IN 10_1101-2021_01_06_425584 241 4 phosphocholine phosphocholine NN 10_1101-2021_01_06_425584 241 5 ( ( -LRB- 10_1101-2021_01_06_425584 241 6 ~ ~ NFP 10_1101-2021_01_06_425584 241 7 460 460 CD 10_1101-2021_01_06_425584 241 8 % % NN 10_1101-2021_01_06_425584 241 9 ) ) -RRB- 10_1101-2021_01_06_425584 241 10 453 453 CD 10_1101-2021_01_06_425584 241 11 were be VBD 10_1101-2021_01_06_425584 241 12 detected detect VBN 10_1101-2021_01_06_425584 241 13 in in IN 10_1101-2021_01_06_425584 241 14 HG HG NNP 10_1101-2021_01_06_425584 241 15 treated treat VBN 10_1101-2021_01_06_425584 241 16 cells cell NNS 10_1101-2021_01_06_425584 241 17 compared compare VBN 10_1101-2021_01_06_425584 241 18 to to IN 10_1101-2021_01_06_425584 241 19 control control NN 10_1101-2021_01_06_425584 241 20 , , , 10_1101-2021_01_06_425584 241 21 that that DT 10_1101-2021_01_06_425584 241 22 could could MD 10_1101-2021_01_06_425584 241 23 be be VB 10_1101-2021_01_06_425584 241 24 associated associate VBN 10_1101-2021_01_06_425584 241 25 with with IN 10_1101-2021_01_06_425584 241 26 the the DT 10_1101-2021_01_06_425584 241 27 454 454 CD 10_1101-2021_01_06_425584 241 28 degradation degradation NN 10_1101-2021_01_06_425584 241 29 of of IN 10_1101-2021_01_06_425584 241 30 LysoPC LysoPC NNP 10_1101-2021_01_06_425584 241 31 lipids lipid VBZ 10_1101-2021_01_06_425584 241 32 . . . 10_1101-2021_01_06_425584 242 1 It -PRON- PRP 10_1101-2021_01_06_425584 242 2 should should MD 10_1101-2021_01_06_425584 242 3 be be VB 10_1101-2021_01_06_425584 242 4 noted note VBN 10_1101-2021_01_06_425584 242 5 that that IN 10_1101-2021_01_06_425584 242 6 the the DT 10_1101-2021_01_06_425584 242 7 use use NN 10_1101-2021_01_06_425584 242 8 of of IN 10_1101-2021_01_06_425584 242 9 pathways pathway NNS 10_1101-2021_01_06_425584 242 10 databases database NNS 10_1101-2021_01_06_425584 242 11 such such JJ 10_1101-2021_01_06_425584 242 12 as as IN 10_1101-2021_01_06_425584 242 13 455 455 CD 10_1101-2021_01_06_425584 242 14 KEGG KEGG NNP 10_1101-2021_01_06_425584 242 15 and and CC 10_1101-2021_01_06_425584 242 16 REACTOME reactome NN 10_1101-2021_01_06_425584 242 17 possess possess VBP 10_1101-2021_01_06_425584 242 18 some some DT 10_1101-2021_01_06_425584 242 19 limitations limitation NNS 10_1101-2021_01_06_425584 242 20 when when WRB 10_1101-2021_01_06_425584 242 21 dealing deal VBG 10_1101-2021_01_06_425584 242 22 with with IN 10_1101-2021_01_06_425584 242 23 lipid lipid NN 10_1101-2021_01_06_425584 242 24 metabolites metabolite NNS 10_1101-2021_01_06_425584 242 25 because because IN 10_1101-2021_01_06_425584 242 26 456 456 CD 10_1101-2021_01_06_425584 242 27 its -PRON- PRP$ 10_1101-2021_01_06_425584 242 28 chemical chemical NN 10_1101-2021_01_06_425584 242 29 diversity diversity NN 10_1101-2021_01_06_425584 242 30 is be VBZ 10_1101-2021_01_06_425584 242 31 not not RB 10_1101-2021_01_06_425584 242 32 well well RB 10_1101-2021_01_06_425584 242 33 annotated annotate VBN 10_1101-2021_01_06_425584 242 34 / / SYM 10_1101-2021_01_06_425584 242 35 defined define VBN 10_1101-2021_01_06_425584 242 36 within within IN 10_1101-2021_01_06_425584 242 37 the the DT 10_1101-2021_01_06_425584 242 38 databases database NNS 10_1101-2021_01_06_425584 242 39 . . . 10_1101-2021_01_06_425584 243 1 For for IN 10_1101-2021_01_06_425584 243 2 example example NN 10_1101-2021_01_06_425584 243 3 , , , 10_1101-2021_01_06_425584 243 4 KEGG KEGG NNP 10_1101-2021_01_06_425584 243 5 457 457 CD 10_1101-2021_01_06_425584 243 6 .CC .CC : 10_1101-2021_01_06_425584 243 7 - - HYPH 10_1101-2021_01_06_425584 243 8 BY by IN 10_1101-2021_01_06_425584 243 9 - - HYPH 10_1101-2021_01_06_425584 243 10 NC NC NNP 10_1101-2021_01_06_425584 243 11 - - HYPH 10_1101-2021_01_06_425584 243 12 ND ND NNP 10_1101-2021_01_06_425584 243 13 4.0 4.0 CD 10_1101-2021_01_06_425584 243 14 International International NNP 10_1101-2021_01_06_425584 243 15 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 243 16 under under IN 10_1101-2021_01_06_425584 243 17 a a DT 10_1101-2021_01_06_425584 243 18 ( ( -LRB- 10_1101-2021_01_06_425584 243 19 which which WDT 10_1101-2021_01_06_425584 243 20 was be VBD 10_1101-2021_01_06_425584 243 21 not not RB 10_1101-2021_01_06_425584 243 22 certified certify VBN 10_1101-2021_01_06_425584 243 23 by by IN 10_1101-2021_01_06_425584 243 24 peer peer NN 10_1101-2021_01_06_425584 243 25 review review NN 10_1101-2021_01_06_425584 243 26 ) ) -RRB- 10_1101-2021_01_06_425584 243 27 is be VBZ 10_1101-2021_01_06_425584 243 28 the the DT 10_1101-2021_01_06_425584 243 29 author author NN 10_1101-2021_01_06_425584 243 30 / / SYM 10_1101-2021_01_06_425584 243 31 funder funder NN 10_1101-2021_01_06_425584 243 32 , , , 10_1101-2021_01_06_425584 243 33 who who WP 10_1101-2021_01_06_425584 243 34 has have VBZ 10_1101-2021_01_06_425584 243 35 granted grant VBN 10_1101-2021_01_06_425584 243 36 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 243 37 a a DT 10_1101-2021_01_06_425584 243 38 license license NN 10_1101-2021_01_06_425584 243 39 to to TO 10_1101-2021_01_06_425584 243 40 display display VB 10_1101-2021_01_06_425584 243 41 the the DT 10_1101-2021_01_06_425584 243 42 preprint preprint NN 10_1101-2021_01_06_425584 243 43 in in IN 10_1101-2021_01_06_425584 243 44 perpetuity perpetuity NN 10_1101-2021_01_06_425584 243 45 . . . 10_1101-2021_01_06_425584 244 1 It -PRON- PRP 10_1101-2021_01_06_425584 244 2 is be VBZ 10_1101-2021_01_06_425584 244 3 made make VBN 10_1101-2021_01_06_425584 244 4 The the DT 10_1101-2021_01_06_425584 244 5 copyright copyright NN 10_1101-2021_01_06_425584 244 6 holder holder NN 10_1101-2021_01_06_425584 244 7 for for IN 10_1101-2021_01_06_425584 244 8 this this DT 10_1101-2021_01_06_425584 244 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 244 10 version version NN 10_1101-2021_01_06_425584 244 11 posted post VBD 10_1101-2021_01_06_425584 244 12 January January NNP 10_1101-2021_01_06_425584 244 13 8 8 CD 10_1101-2021_01_06_425584 244 14 , , , 10_1101-2021_01_06_425584 244 15 2021 2021 CD 10_1101-2021_01_06_425584 244 16 . . . 10_1101-2021_01_06_425584 244 17 ; ; : 10_1101-2021_01_06_425584 244 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 244 19 : : : 10_1101-2021_01_06_425584 244 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 244 21 preprint preprint NN 10_1101-2021_01_06_425584 244 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 244 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 244 24 15 15 CD 10_1101-2021_01_06_425584 244 25 provides provide VBZ 10_1101-2021_01_06_425584 244 26 a a DT 10_1101-2021_01_06_425584 244 27 chemical chemical JJ 10_1101-2021_01_06_425584 244 28 class class NN 10_1101-2021_01_06_425584 244 29 identifier identifier NN 10_1101-2021_01_06_425584 244 30 instead instead RB 10_1101-2021_01_06_425584 244 31 of of IN 10_1101-2021_01_06_425584 244 32 individual individual JJ 10_1101-2021_01_06_425584 244 33 identity identity NN 10_1101-2021_01_06_425584 244 34 to to IN 10_1101-2021_01_06_425584 244 35 lipids lipid NNS 10_1101-2021_01_06_425584 244 36 , , , 10_1101-2021_01_06_425584 244 37 constricting constrict VBG 10_1101-2021_01_06_425584 244 38 their -PRON- PRP$ 10_1101-2021_01_06_425584 244 39 458 458 CD 10_1101-2021_01_06_425584 244 40 biological biological JJ 10_1101-2021_01_06_425584 244 41 importance importance NN 10_1101-2021_01_06_425584 244 42 ( ( -LRB- 10_1101-2021_01_06_425584 244 43 79 79 CD 10_1101-2021_01_06_425584 244 44 ) ) -RRB- 10_1101-2021_01_06_425584 244 45 . . . 10_1101-2021_01_06_425584 245 1 Thus thus RB 10_1101-2021_01_06_425584 245 2 , , , 10_1101-2021_01_06_425584 245 3 based base VBN 10_1101-2021_01_06_425584 245 4 on on IN 10_1101-2021_01_06_425584 245 5 our -PRON- PRP$ 10_1101-2021_01_06_425584 245 6 manual manual JJ 10_1101-2021_01_06_425584 245 7 inspection inspection NN 10_1101-2021_01_06_425584 245 8 of of IN 10_1101-2021_01_06_425584 245 9 the the DT 10_1101-2021_01_06_425584 245 10 metabolomics-459 metabolomics-459 NNP 10_1101-2021_01_06_425584 245 11 proteomics proteomic NNS 10_1101-2021_01_06_425584 245 12 data datum NNS 10_1101-2021_01_06_425584 245 13 and and CC 10_1101-2021_01_06_425584 245 14 in in IN 10_1101-2021_01_06_425584 245 15 line line NN 10_1101-2021_01_06_425584 245 16 with with IN 10_1101-2021_01_06_425584 245 17 the the DT 10_1101-2021_01_06_425584 245 18 evidence evidence NN 10_1101-2021_01_06_425584 245 19 , , , 10_1101-2021_01_06_425584 245 20 we -PRON- PRP 10_1101-2021_01_06_425584 245 21 suggest suggest VBP 10_1101-2021_01_06_425584 245 22 that that IN 10_1101-2021_01_06_425584 245 23 simulated simulate VBN 10_1101-2021_01_06_425584 245 24 diabetes diabetes NN 10_1101-2021_01_06_425584 245 25 evokes evoke VBZ 10_1101-2021_01_06_425584 245 26 460 460 CD 10_1101-2021_01_06_425584 245 27 inflammation inflammation NN 10_1101-2021_01_06_425584 245 28 on on IN 10_1101-2021_01_06_425584 245 29 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 245 30 and and CC 10_1101-2021_01_06_425584 245 31 that that IN 10_1101-2021_01_06_425584 245 32 PAFAH1B2 PAFAH1B2 NNP 10_1101-2021_01_06_425584 245 33 and and CC 10_1101-2021_01_06_425584 245 34 LYPLA1 LYPLA1 NNP 10_1101-2021_01_06_425584 245 35 play play VBP 10_1101-2021_01_06_425584 245 36 a a DT 10_1101-2021_01_06_425584 245 37 role role NN 10_1101-2021_01_06_425584 245 38 in in IN 10_1101-2021_01_06_425584 245 39 modulating modulate VBG 10_1101-2021_01_06_425584 245 40 such such JJ 10_1101-2021_01_06_425584 245 41 461 461 CD 10_1101-2021_01_06_425584 245 42 process process NN 10_1101-2021_01_06_425584 245 43 . . . 10_1101-2021_01_06_425584 246 1 462 462 CD 10_1101-2021_01_06_425584 246 2 Previously previously RB 10_1101-2021_01_06_425584 246 3 , , , 10_1101-2021_01_06_425584 246 4 we -PRON- PRP 10_1101-2021_01_06_425584 246 5 reported report VBD 10_1101-2021_01_06_425584 246 6 the the DT 10_1101-2021_01_06_425584 246 7 multinucleation multinucleation NN 10_1101-2021_01_06_425584 246 8 of of IN 10_1101-2021_01_06_425584 246 9 CAEC caec NN 10_1101-2021_01_06_425584 246 10 cultured culture VBN 10_1101-2021_01_06_425584 246 11 under under IN 10_1101-2021_01_06_425584 246 12 simulated simulate VBN 10_1101-2021_01_06_425584 246 13 diabetes diabete NNS 10_1101-2021_01_06_425584 246 14 ( ( -LRB- 10_1101-2021_01_06_425584 246 15 15 15 CD 10_1101-2021_01_06_425584 246 16 ) ) -RRB- 10_1101-2021_01_06_425584 246 17 . . . 10_1101-2021_01_06_425584 247 1 This this DT 10_1101-2021_01_06_425584 247 2 463 463 CD 10_1101-2021_01_06_425584 247 3 type type NN 10_1101-2021_01_06_425584 247 4 of of IN 10_1101-2021_01_06_425584 247 5 cell cell NN 10_1101-2021_01_06_425584 247 6 possesses possess VBZ 10_1101-2021_01_06_425584 247 7 ≥2 ≥2 NNP 10_1101-2021_01_06_425584 247 8 nuclei nucleus NNS 10_1101-2021_01_06_425584 247 9 . . . 10_1101-2021_01_06_425584 248 1 Here here RB 10_1101-2021_01_06_425584 248 2 , , , 10_1101-2021_01_06_425584 248 3 we -PRON- PRP 10_1101-2021_01_06_425584 248 4 replicated replicate VBD 10_1101-2021_01_06_425584 248 5 our -PRON- PRP$ 10_1101-2021_01_06_425584 248 6 previous previous JJ 10_1101-2021_01_06_425584 248 7 findings finding NNS 10_1101-2021_01_06_425584 248 8 of of IN 10_1101-2021_01_06_425584 248 9 increased increase VBN 10_1101-2021_01_06_425584 248 10 464 464 CD 10_1101-2021_01_06_425584 248 11 binucleation binucleation NN 10_1101-2021_01_06_425584 248 12 in in IN 10_1101-2021_01_06_425584 248 13 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 248 14 . . . 10_1101-2021_01_06_425584 249 1 The the DT 10_1101-2021_01_06_425584 249 2 same same JJ 10_1101-2021_01_06_425584 249 3 outcome outcome NN 10_1101-2021_01_06_425584 249 4 was be VBD 10_1101-2021_01_06_425584 249 5 obtained obtain VBN 10_1101-2021_01_06_425584 249 6 when when WRB 10_1101-2021_01_06_425584 249 7 using use VBG 10_1101-2021_01_06_425584 249 8 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 249 9 as as IN 10_1101-2021_01_06_425584 249 10 a a DT 10_1101-2021_01_06_425584 249 11 human human NN 10_1101-2021_01_06_425584 249 12 in in FW 10_1101-2021_01_06_425584 249 13 vitro vitro FW 10_1101-2021_01_06_425584 249 14 465 465 CD 10_1101-2021_01_06_425584 249 15 model model NN 10_1101-2021_01_06_425584 249 16 ( ( -LRB- 10_1101-2021_01_06_425584 249 17 Figure figure NN 10_1101-2021_01_06_425584 249 18 7A 7a NN 10_1101-2021_01_06_425584 249 19 and and CC 10_1101-2021_01_06_425584 249 20 7B 7b NN 10_1101-2021_01_06_425584 249 21 ) ) -RRB- 10_1101-2021_01_06_425584 249 22 , , , 10_1101-2021_01_06_425584 249 23 validating validate VBG 10_1101-2021_01_06_425584 249 24 the the DT 10_1101-2021_01_06_425584 249 25 binucleation binucleation NN 10_1101-2021_01_06_425584 249 26 process process NN 10_1101-2021_01_06_425584 249 27 in in IN 10_1101-2021_01_06_425584 249 28 other other JJ 10_1101-2021_01_06_425584 249 29 CAEC caec NN 10_1101-2021_01_06_425584 249 30 . . . 10_1101-2021_01_06_425584 250 1 After after IN 10_1101-2021_01_06_425584 250 2 refinement refinement JJ 10_1101-2021_01_06_425584 250 3 466 466 CD 10_1101-2021_01_06_425584 250 4 of of IN 10_1101-2021_01_06_425584 250 5 LC LC NNP 10_1101-2021_01_06_425584 250 6 - - HYPH 10_1101-2021_01_06_425584 250 7 MS2 MS2 NNP 10_1101-2021_01_06_425584 250 8 data datum NNS 10_1101-2021_01_06_425584 250 9 and and CC 10_1101-2021_01_06_425584 250 10 bioinformatics bioinformatic NNS 10_1101-2021_01_06_425584 250 11 re re NN 10_1101-2021_01_06_425584 250 12 - - NN 10_1101-2021_01_06_425584 250 13 processing processing NN 10_1101-2021_01_06_425584 250 14 of of IN 10_1101-2021_01_06_425584 250 15 published publish VBN 10_1101-2021_01_06_425584 250 16 SWATH SWATH NNP 10_1101-2021_01_06_425584 250 17 - - HYPH 10_1101-2021_01_06_425584 250 18 based base VBN 10_1101-2021_01_06_425584 250 19 datasets dataset NNS 10_1101-2021_01_06_425584 250 20 of of IN 10_1101-2021_01_06_425584 250 21 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 250 22 467 467 CD 10_1101-2021_01_06_425584 250 23 under under IN 10_1101-2021_01_06_425584 250 24 simulated simulate VBN 10_1101-2021_01_06_425584 250 25 diabetes diabete NNS 10_1101-2021_01_06_425584 250 26 ( ( -LRB- 10_1101-2021_01_06_425584 250 27 15 15 CD 10_1101-2021_01_06_425584 250 28 ) ) -RRB- 10_1101-2021_01_06_425584 250 29 , , , 10_1101-2021_01_06_425584 250 30 molecular molecular JJ 10_1101-2021_01_06_425584 250 31 signatures signature NNS 10_1101-2021_01_06_425584 250 32 and and CC 10_1101-2021_01_06_425584 250 33 pathways pathway NNS 10_1101-2021_01_06_425584 250 34 that that WDT 10_1101-2021_01_06_425584 250 35 could could MD 10_1101-2021_01_06_425584 250 36 be be VB 10_1101-2021_01_06_425584 250 37 linked link VBN 10_1101-2021_01_06_425584 250 38 to to IN 10_1101-2021_01_06_425584 250 39 the the DT 10_1101-2021_01_06_425584 250 40 468 468 CD 10_1101-2021_01_06_425584 250 41 binucleation binucleation NN 10_1101-2021_01_06_425584 250 42 process process NN 10_1101-2021_01_06_425584 250 43 were be VBD 10_1101-2021_01_06_425584 250 44 found find VBN 10_1101-2021_01_06_425584 250 45 ( ( -LRB- 10_1101-2021_01_06_425584 250 46 Figure figure NN 10_1101-2021_01_06_425584 250 47 8) 8) CD 10_1101-2021_01_06_425584 250 48 . . . 10_1101-2021_01_06_425584 251 1 For for IN 10_1101-2021_01_06_425584 251 2 instance instance NN 10_1101-2021_01_06_425584 251 3 , , , 10_1101-2021_01_06_425584 251 4 we -PRON- PRP 10_1101-2021_01_06_425584 251 5 noted note VBD 10_1101-2021_01_06_425584 251 6 an an DT 10_1101-2021_01_06_425584 251 7 increased increase VBN 10_1101-2021_01_06_425584 251 8 abundance abundance NN 10_1101-2021_01_06_425584 251 9 of of IN 10_1101-2021_01_06_425584 251 10 469 469 CD 10_1101-2021_01_06_425584 251 11 proteins protein NNS 10_1101-2021_01_06_425584 251 12 , , , 10_1101-2021_01_06_425584 251 13 under under IN 10_1101-2021_01_06_425584 251 14 simulated simulated JJ 10_1101-2021_01_06_425584 251 15 diabetes diabete NNS 10_1101-2021_01_06_425584 251 16 , , , 10_1101-2021_01_06_425584 251 17 with with IN 10_1101-2021_01_06_425584 251 18 reported report VBN 10_1101-2021_01_06_425584 251 19 nuclei nuclei NN 10_1101-2021_01_06_425584 251 20 localization localization NN 10_1101-2021_01_06_425584 251 21 and and CC 10_1101-2021_01_06_425584 251 22 linked link VBN 10_1101-2021_01_06_425584 251 23 to to IN 10_1101-2021_01_06_425584 251 24 DNA dna NN 10_1101-2021_01_06_425584 251 25 470 470 CD 10_1101-2021_01_06_425584 251 26 metabolism metabolism NN 10_1101-2021_01_06_425584 251 27 , , , 10_1101-2021_01_06_425584 251 28 including include VBG 10_1101-2021_01_06_425584 251 29 ribosomal ribosomal JJ 10_1101-2021_01_06_425584 251 30 proteins protein NNS 10_1101-2021_01_06_425584 251 31 RPS7 RPS7 NNP 10_1101-2021_01_06_425584 251 32 , , , 10_1101-2021_01_06_425584 251 33 RPS13 RPS13 NNP 10_1101-2021_01_06_425584 251 34 , , , 10_1101-2021_01_06_425584 251 35 and and CC 10_1101-2021_01_06_425584 251 36 RPL9 RPL9 NNP 10_1101-2021_01_06_425584 251 37 ( ( -LRB- 10_1101-2021_01_06_425584 251 38 80 80 CD 10_1101-2021_01_06_425584 251 39 ) ) -RRB- 10_1101-2021_01_06_425584 251 40 . . . 10_1101-2021_01_06_425584 252 1 Further further RB 10_1101-2021_01_06_425584 252 2 , , , 10_1101-2021_01_06_425584 252 3 we -PRON- PRP 10_1101-2021_01_06_425584 252 4 observed observe VBD 10_1101-2021_01_06_425584 252 5 471 471 CD 10_1101-2021_01_06_425584 252 6 an an DT 10_1101-2021_01_06_425584 252 7 increased increase VBN 10_1101-2021_01_06_425584 252 8 abundance abundance NN 10_1101-2021_01_06_425584 252 9 of of IN 10_1101-2021_01_06_425584 252 10 proteasome proteasome JJ 10_1101-2021_01_06_425584 252 11 proteins protein NNS 10_1101-2021_01_06_425584 252 12 , , , 10_1101-2021_01_06_425584 252 13 PSMA4 PSMA4 '' 10_1101-2021_01_06_425584 252 14 and and CC 10_1101-2021_01_06_425584 252 15 PSMD3 PSMD3 NNP 10_1101-2021_01_06_425584 252 16 , , , 10_1101-2021_01_06_425584 252 17 which which WDT 10_1101-2021_01_06_425584 252 18 are be VBP 10_1101-2021_01_06_425584 252 19 linked link VBN 10_1101-2021_01_06_425584 252 20 to to IN 10_1101-2021_01_06_425584 252 21 protein protein NN 10_1101-2021_01_06_425584 252 22 472 472 CD 10_1101-2021_01_06_425584 252 23 metabolism metabolism NN 10_1101-2021_01_06_425584 252 24 ( ( -LRB- 10_1101-2021_01_06_425584 252 25 81 81 CD 10_1101-2021_01_06_425584 252 26 ) ) -RRB- 10_1101-2021_01_06_425584 252 27 . . . 10_1101-2021_01_06_425584 253 1 Hence hence RB 10_1101-2021_01_06_425584 253 2 , , , 10_1101-2021_01_06_425584 253 3 we -PRON- PRP 10_1101-2021_01_06_425584 253 4 infer infer VBP 10_1101-2021_01_06_425584 253 5 that that IN 10_1101-2021_01_06_425584 253 6 the the DT 10_1101-2021_01_06_425584 253 7 CAEC caec NN 10_1101-2021_01_06_425584 253 8 binucleation binucleation NN 10_1101-2021_01_06_425584 253 9 occurs occur VBZ 10_1101-2021_01_06_425584 253 10 as as IN 10_1101-2021_01_06_425584 253 11 a a DT 10_1101-2021_01_06_425584 253 12 compensatory compensatory JJ 10_1101-2021_01_06_425584 253 13 473 473 CD 10_1101-2021_01_06_425584 253 14 mechanism mechanism NN 10_1101-2021_01_06_425584 253 15 to to TO 10_1101-2021_01_06_425584 253 16 increase increase VB 10_1101-2021_01_06_425584 253 17 the the DT 10_1101-2021_01_06_425584 253 18 cell cell NN 10_1101-2021_01_06_425584 253 19 capacity capacity NN 10_1101-2021_01_06_425584 253 20 to to TO 10_1101-2021_01_06_425584 253 21 metabolize metabolize VB 10_1101-2021_01_06_425584 253 22 the the DT 10_1101-2021_01_06_425584 253 23 excess excess NN 10_1101-2021_01_06_425584 253 24 of of IN 10_1101-2021_01_06_425584 253 25 ambient ambient JJ 10_1101-2021_01_06_425584 253 26 glucose glucose NN 10_1101-2021_01_06_425584 253 27 by by IN 10_1101-2021_01_06_425584 253 28 474 474 CD 10_1101-2021_01_06_425584 253 29 increasing increase VBG 10_1101-2021_01_06_425584 253 30 the the DT 10_1101-2021_01_06_425584 253 31 cell cell NN 10_1101-2021_01_06_425584 253 32 metabolic metabolic JJ 10_1101-2021_01_06_425584 253 33 machinery machinery NN 10_1101-2021_01_06_425584 253 34 ( ( -LRB- 10_1101-2021_01_06_425584 253 35 transcription transcription NN 10_1101-2021_01_06_425584 253 36 / / SYM 10_1101-2021_01_06_425584 253 37 translation translation NN 10_1101-2021_01_06_425584 253 38 processes process NNS 10_1101-2021_01_06_425584 253 39 ) ) -RRB- 10_1101-2021_01_06_425584 253 40 . . . 10_1101-2021_01_06_425584 254 1 Although although IN 10_1101-2021_01_06_425584 254 2 an an DT 10_1101-2021_01_06_425584 254 3 475 475 CD 10_1101-2021_01_06_425584 254 4 increase increase NN 10_1101-2021_01_06_425584 254 5 in in IN 10_1101-2021_01_06_425584 254 6 cell cell NN 10_1101-2021_01_06_425584 254 7 proliferation proliferation NN 10_1101-2021_01_06_425584 254 8 could could MD 10_1101-2021_01_06_425584 254 9 boost boost VB 10_1101-2021_01_06_425584 254 10 a a DT 10_1101-2021_01_06_425584 254 11 coordinated coordinated JJ 10_1101-2021_01_06_425584 254 12 increase increase NN 10_1101-2021_01_06_425584 254 13 of of IN 10_1101-2021_01_06_425584 254 14 ribosomal ribosomal NN 10_1101-2021_01_06_425584 254 15 and and CC 10_1101-2021_01_06_425584 254 16 proteasome proteasome JJ 10_1101-2021_01_06_425584 254 17 476 476 CD 10_1101-2021_01_06_425584 254 18 proteins protein NNS 10_1101-2021_01_06_425584 254 19 , , , 10_1101-2021_01_06_425584 254 20 we -PRON- PRP 10_1101-2021_01_06_425584 254 21 do do VBP 10_1101-2021_01_06_425584 254 22 not not RB 10_1101-2021_01_06_425584 254 23 believe believe VB 10_1101-2021_01_06_425584 254 24 this this DT 10_1101-2021_01_06_425584 254 25 is be VBZ 10_1101-2021_01_06_425584 254 26 the the DT 10_1101-2021_01_06_425584 254 27 case case NN 10_1101-2021_01_06_425584 254 28 here here RB 10_1101-2021_01_06_425584 254 29 , , , 10_1101-2021_01_06_425584 254 30 as as IN 10_1101-2021_01_06_425584 254 31 mentioned mention VBN 10_1101-2021_01_06_425584 254 32 before before RB 10_1101-2021_01_06_425584 254 33 . . . 10_1101-2021_01_06_425584 255 1 After after IN 10_1101-2021_01_06_425584 255 2 4 4 CD 10_1101-2021_01_06_425584 255 3 - - SYM 10_1101-2021_01_06_425584 255 4 5 5 CD 10_1101-2021_01_06_425584 255 5 days day NNS 10_1101-2021_01_06_425584 255 6 of of IN 10_1101-2021_01_06_425584 255 7 simulated simulate VBN 10_1101-2021_01_06_425584 255 8 477 477 CD 10_1101-2021_01_06_425584 255 9 diabetes diabete NNS 10_1101-2021_01_06_425584 255 10 , , , 10_1101-2021_01_06_425584 255 11 cells cell NNS 10_1101-2021_01_06_425584 255 12 occupied occupy VBD 10_1101-2021_01_06_425584 255 13 100 100 CD 10_1101-2021_01_06_425584 255 14 % % NN 10_1101-2021_01_06_425584 255 15 of of IN 10_1101-2021_01_06_425584 255 16 the the DT 10_1101-2021_01_06_425584 255 17 well well NN 10_1101-2021_01_06_425584 255 18 's 's POS 10_1101-2021_01_06_425584 255 19 plate plate NN 10_1101-2021_01_06_425584 255 20 surface surface NN 10_1101-2021_01_06_425584 255 21 , , , 10_1101-2021_01_06_425584 255 22 thereby thereby RB 10_1101-2021_01_06_425584 255 23 impeding impede VBG 10_1101-2021_01_06_425584 255 24 to to TO 10_1101-2021_01_06_425584 255 25 harbor harbor VB 10_1101-2021_01_06_425584 255 26 more more JJR 10_1101-2021_01_06_425584 255 27 cells cell NNS 10_1101-2021_01_06_425584 255 28 478 478 CD 10_1101-2021_01_06_425584 255 29 because because IN 10_1101-2021_01_06_425584 255 30 endothelial endothelial JJ 10_1101-2021_01_06_425584 255 31 cells cell NNS 10_1101-2021_01_06_425584 255 32 grow grow VBP 10_1101-2021_01_06_425584 255 33 as as IN 10_1101-2021_01_06_425584 255 34 a a DT 10_1101-2021_01_06_425584 255 35 monolayer monolayer NN 10_1101-2021_01_06_425584 255 36 . . . 10_1101-2021_01_06_425584 256 1 This this DT 10_1101-2021_01_06_425584 256 2 is be VBZ 10_1101-2021_01_06_425584 256 3 consistent consistent JJ 10_1101-2021_01_06_425584 256 4 with with IN 10_1101-2021_01_06_425584 256 5 findings finding NNS 10_1101-2021_01_06_425584 256 6 stating state VBG 10_1101-2021_01_06_425584 256 7 that that IN 10_1101-2021_01_06_425584 256 8 when when WRB 10_1101-2021_01_06_425584 256 9 479 479 CD 10_1101-2021_01_06_425584 256 10 endothelial endothelial JJ 10_1101-2021_01_06_425584 256 11 cells cell NNS 10_1101-2021_01_06_425584 256 12 become become VBP 10_1101-2021_01_06_425584 256 13 highly highly RB 10_1101-2021_01_06_425584 256 14 confluent confluent JJ 10_1101-2021_01_06_425584 256 15 , , , 10_1101-2021_01_06_425584 256 16 they -PRON- PRP 10_1101-2021_01_06_425584 256 17 stop stop VBP 10_1101-2021_01_06_425584 256 18 growing grow VBG 10_1101-2021_01_06_425584 256 19 due due JJ 10_1101-2021_01_06_425584 256 20 to to IN 10_1101-2021_01_06_425584 256 21 cell cell NN 10_1101-2021_01_06_425584 256 22 - - HYPH 10_1101-2021_01_06_425584 256 23 cell cell NN 10_1101-2021_01_06_425584 256 24 contact contact NN 10_1101-2021_01_06_425584 256 25 , , , 10_1101-2021_01_06_425584 256 26 even even RB 10_1101-2021_01_06_425584 256 27 in in IN 10_1101-2021_01_06_425584 256 28 the the DT 10_1101-2021_01_06_425584 256 29 480 480 CD 10_1101-2021_01_06_425584 256 30 presence presence NN 10_1101-2021_01_06_425584 256 31 of of IN 10_1101-2021_01_06_425584 256 32 growth growth NN 10_1101-2021_01_06_425584 256 33 factors factor NNS 10_1101-2021_01_06_425584 256 34 ( ( -LRB- 10_1101-2021_01_06_425584 256 35 82 82 CD 10_1101-2021_01_06_425584 256 36 ) ) -RRB- 10_1101-2021_01_06_425584 256 37 . . . 10_1101-2021_01_06_425584 257 1 In in IN 10_1101-2021_01_06_425584 257 2 support support NN 10_1101-2021_01_06_425584 257 3 of of IN 10_1101-2021_01_06_425584 257 4 this this DT 10_1101-2021_01_06_425584 257 5 , , , 10_1101-2021_01_06_425584 257 6 up up NN 10_1101-2021_01_06_425584 257 7 - - HYPH 10_1101-2021_01_06_425584 257 8 stream stream NN 10_1101-2021_01_06_425584 257 9 ( ( -LRB- 10_1101-2021_01_06_425584 257 10 CTGF CTGF NNP 10_1101-2021_01_06_425584 257 11 and and CC 10_1101-2021_01_06_425584 257 12 CD62 CD62 NNP 10_1101-2021_01_06_425584 257 13 ) ) -RRB- 10_1101-2021_01_06_425584 257 14 ( ( -LRB- 10_1101-2021_01_06_425584 257 15 83 83 CD 10_1101-2021_01_06_425584 257 16 , , , 10_1101-2021_01_06_425584 257 17 84 84 CD 10_1101-2021_01_06_425584 257 18 ) ) -RRB- 10_1101-2021_01_06_425584 257 19 ( ( -LRB- 10_1101-2021_01_06_425584 257 20 Table table NN 10_1101-2021_01_06_425584 257 21 481 481 CD 10_1101-2021_01_06_425584 257 22 S5 s5 NN 10_1101-2021_01_06_425584 257 23 ) ) -RRB- 10_1101-2021_01_06_425584 257 24 and and CC 10_1101-2021_01_06_425584 257 25 down down IN 10_1101-2021_01_06_425584 257 26 - - HYPH 10_1101-2021_01_06_425584 257 27 stream stream NN 10_1101-2021_01_06_425584 257 28 proteins protein NNS 10_1101-2021_01_06_425584 257 29 ( ( -LRB- 10_1101-2021_01_06_425584 257 30 FABP4 fabp4 $ 10_1101-2021_01_06_425584 257 31 ) ) -RRB- 10_1101-2021_01_06_425584 257 32 ( ( -LRB- 10_1101-2021_01_06_425584 257 33 85 85 CD 10_1101-2021_01_06_425584 257 34 ) ) -RRB- 10_1101-2021_01_06_425584 257 35 ( ( -LRB- 10_1101-2021_01_06_425584 257 36 Table table NN 10_1101-2021_01_06_425584 257 37 S5 s5 NN 10_1101-2021_01_06_425584 257 38 ) ) -RRB- 10_1101-2021_01_06_425584 257 39 involved involve VBN 10_1101-2021_01_06_425584 257 40 in in IN 10_1101-2021_01_06_425584 257 41 angiogenesis angiogenesis NN 10_1101-2021_01_06_425584 257 42 and and CC 10_1101-2021_01_06_425584 257 43 proliferation proliferation NN 10_1101-2021_01_06_425584 257 44 482 482 CD 10_1101-2021_01_06_425584 257 45 were be VBD 10_1101-2021_01_06_425584 257 46 down down RB 10_1101-2021_01_06_425584 257 47 - - HYPH 10_1101-2021_01_06_425584 257 48 regulated regulate VBN 10_1101-2021_01_06_425584 257 49 by by IN 10_1101-2021_01_06_425584 257 50 simulated simulated JJ 10_1101-2021_01_06_425584 257 51 diabetes diabete NNS 10_1101-2021_01_06_425584 257 52 . . . 10_1101-2021_01_06_425584 258 1 Importantly importantly RB 10_1101-2021_01_06_425584 258 2 , , , 10_1101-2021_01_06_425584 258 3 there there EX 10_1101-2021_01_06_425584 258 4 is be VBZ 10_1101-2021_01_06_425584 258 5 evidence evidence NN 10_1101-2021_01_06_425584 258 6 ( ( -LRB- 10_1101-2021_01_06_425584 258 7 not not RB 10_1101-2021_01_06_425584 258 8 in in IN 10_1101-2021_01_06_425584 258 9 endothelial endothelial JJ 10_1101-2021_01_06_425584 258 10 483 483 CD 10_1101-2021_01_06_425584 258 11 cells cell NNS 10_1101-2021_01_06_425584 258 12 ) ) -RRB- 10_1101-2021_01_06_425584 258 13 of of IN 10_1101-2021_01_06_425584 258 14 cellular cellular JJ 10_1101-2021_01_06_425584 258 15 processes process NNS 10_1101-2021_01_06_425584 258 16 contributing contribute VBG 10_1101-2021_01_06_425584 258 17 to to IN 10_1101-2021_01_06_425584 258 18 the the DT 10_1101-2021_01_06_425584 258 19 stimulation stimulation NN 10_1101-2021_01_06_425584 258 20 of of IN 10_1101-2021_01_06_425584 258 21 cellular cellular JJ 10_1101-2021_01_06_425584 258 22 binucleation binucleation NN 10_1101-2021_01_06_425584 258 23 without without IN 10_1101-2021_01_06_425584 258 24 increases increase NNS 10_1101-2021_01_06_425584 258 25 484 484 CD 10_1101-2021_01_06_425584 258 26 in in IN 10_1101-2021_01_06_425584 258 27 cell cell NN 10_1101-2021_01_06_425584 258 28 proliferation proliferation NN 10_1101-2021_01_06_425584 258 29 , , , 10_1101-2021_01_06_425584 258 30 including include VBG 10_1101-2021_01_06_425584 258 31 cellular cellular JJ 10_1101-2021_01_06_425584 258 32 enhancement enhancement NN 10_1101-2021_01_06_425584 258 33 of of IN 10_1101-2021_01_06_425584 258 34 antimicrobial antimicrobial JJ 10_1101-2021_01_06_425584 258 35 defenses defense NNS 10_1101-2021_01_06_425584 258 36 ( ( -LRB- 10_1101-2021_01_06_425584 258 37 86 86 CD 10_1101-2021_01_06_425584 258 38 ) ) -RRB- 10_1101-2021_01_06_425584 258 39 , , , 10_1101-2021_01_06_425584 258 40 senescence senescence NN 10_1101-2021_01_06_425584 258 41 485 485 CD 10_1101-2021_01_06_425584 258 42 ( ( -LRB- 10_1101-2021_01_06_425584 258 43 87 87 CD 10_1101-2021_01_06_425584 258 44 ) ) -RRB- 10_1101-2021_01_06_425584 258 45 , , , 10_1101-2021_01_06_425584 258 46 and and CC 10_1101-2021_01_06_425584 258 47 malignancy malignancy NNP 10_1101-2021_01_06_425584 258 48 ( ( -LRB- 10_1101-2021_01_06_425584 258 49 88 88 CD 10_1101-2021_01_06_425584 258 50 ) ) -RRB- 10_1101-2021_01_06_425584 258 51 . . . 10_1101-2021_01_06_425584 259 1 Various various JJ 10_1101-2021_01_06_425584 259 2 mechanisms mechanism NNS 10_1101-2021_01_06_425584 259 3 have have VBP 10_1101-2021_01_06_425584 259 4 been be VBN 10_1101-2021_01_06_425584 259 5 linked link VBN 10_1101-2021_01_06_425584 259 6 to to IN 10_1101-2021_01_06_425584 259 7 the the DT 10_1101-2021_01_06_425584 259 8 binucleation binucleation NN 10_1101-2021_01_06_425584 259 9 process process NN 10_1101-2021_01_06_425584 259 10 , , , 10_1101-2021_01_06_425584 259 11 486 486 CD 10_1101-2021_01_06_425584 259 12 such such JJ 10_1101-2021_01_06_425584 259 13 as as IN 10_1101-2021_01_06_425584 259 14 cytokinesis cytokinesis NN 10_1101-2021_01_06_425584 259 15 failure failure NN 10_1101-2021_01_06_425584 259 16 , , , 10_1101-2021_01_06_425584 259 17 cellular cellular JJ 10_1101-2021_01_06_425584 259 18 fusion fusion NN 10_1101-2021_01_06_425584 259 19 , , , 10_1101-2021_01_06_425584 259 20 mitotic mitotic JJ 10_1101-2021_01_06_425584 259 21 slippage slippage NN 10_1101-2021_01_06_425584 259 22 , , , 10_1101-2021_01_06_425584 259 23 and and CC 10_1101-2021_01_06_425584 259 24 endoreduplication endoreduplication NN 10_1101-2021_01_06_425584 259 25 ( ( -LRB- 10_1101-2021_01_06_425584 259 26 89 89 CD 10_1101-2021_01_06_425584 259 27 ) ) -RRB- 10_1101-2021_01_06_425584 259 28 . . . 10_1101-2021_01_06_425584 260 1 The the DT 10_1101-2021_01_06_425584 260 2 487 487 CD 10_1101-2021_01_06_425584 260 3 elucidation elucidation NN 10_1101-2021_01_06_425584 260 4 of of IN 10_1101-2021_01_06_425584 260 5 the the DT 10_1101-2021_01_06_425584 260 6 exact exact JJ 10_1101-2021_01_06_425584 260 7 molecular molecular JJ 10_1101-2021_01_06_425584 260 8 mechanisms mechanism NNS 10_1101-2021_01_06_425584 260 9 leading lead VBG 10_1101-2021_01_06_425584 260 10 to to IN 10_1101-2021_01_06_425584 260 11 the the DT 10_1101-2021_01_06_425584 260 12 binucleation binucleation NN 10_1101-2021_01_06_425584 260 13 process process NN 10_1101-2021_01_06_425584 260 14 of of IN 10_1101-2021_01_06_425584 260 15 CAEC CAEC NNP 10_1101-2021_01_06_425584 260 16 is be VBZ 10_1101-2021_01_06_425584 260 17 488 488 CD 10_1101-2021_01_06_425584 260 18 beyond beyond IN 10_1101-2021_01_06_425584 260 19 the the DT 10_1101-2021_01_06_425584 260 20 scope scope NN 10_1101-2021_01_06_425584 260 21 of of IN 10_1101-2021_01_06_425584 260 22 our -PRON- PRP$ 10_1101-2021_01_06_425584 260 23 study study NN 10_1101-2021_01_06_425584 260 24 . . . 10_1101-2021_01_06_425584 261 1 489 489 CD 10_1101-2021_01_06_425584 261 2 In in IN 10_1101-2021_01_06_425584 261 3 conclusion conclusion NN 10_1101-2021_01_06_425584 261 4 , , , 10_1101-2021_01_06_425584 261 5 this this DT 10_1101-2021_01_06_425584 261 6 study study NN 10_1101-2021_01_06_425584 261 7 applied apply VBD 10_1101-2021_01_06_425584 261 8 an an DT 10_1101-2021_01_06_425584 261 9 integrated integrated JJ 10_1101-2021_01_06_425584 261 10 multi multi JJ 10_1101-2021_01_06_425584 261 11 - - NNS 10_1101-2021_01_06_425584 261 12 omics omic NNS 10_1101-2021_01_06_425584 261 13 and and CC 10_1101-2021_01_06_425584 261 14 bioinformatics bioinformatic NNS 10_1101-2021_01_06_425584 261 15 / / SYM 10_1101-2021_01_06_425584 261 16 chemoinformatics chemoinformatic NNS 10_1101-2021_01_06_425584 261 17 490 490 CD 10_1101-2021_01_06_425584 261 18 approach approach NN 10_1101-2021_01_06_425584 261 19 to to TO 10_1101-2021_01_06_425584 261 20 characterize characterize VB 10_1101-2021_01_06_425584 261 21 the the DT 10_1101-2021_01_06_425584 261 22 molecular molecular JJ 10_1101-2021_01_06_425584 261 23 perturbations perturbation NNS 10_1101-2021_01_06_425584 261 24 that that WDT 10_1101-2021_01_06_425584 261 25 simulated simulate VBD 10_1101-2021_01_06_425584 261 26 diabetes diabetes NN 10_1101-2021_01_06_425584 261 27 exerts exert NNS 10_1101-2021_01_06_425584 261 28 on on IN 10_1101-2021_01_06_425584 261 29 CAEC caec NN 10_1101-2021_01_06_425584 261 30 . . . 10_1101-2021_01_06_425584 262 1 491 491 CD 10_1101-2021_01_06_425584 262 2 .CC .CC : 10_1101-2021_01_06_425584 262 3 - - HYPH 10_1101-2021_01_06_425584 262 4 BY by IN 10_1101-2021_01_06_425584 262 5 - - HYPH 10_1101-2021_01_06_425584 262 6 NC NC NNP 10_1101-2021_01_06_425584 262 7 - - HYPH 10_1101-2021_01_06_425584 262 8 ND ND NNP 10_1101-2021_01_06_425584 262 9 4.0 4.0 CD 10_1101-2021_01_06_425584 262 10 International International NNP 10_1101-2021_01_06_425584 262 11 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 262 12 under under IN 10_1101-2021_01_06_425584 262 13 a a DT 10_1101-2021_01_06_425584 262 14 ( ( -LRB- 10_1101-2021_01_06_425584 262 15 which which WDT 10_1101-2021_01_06_425584 262 16 was be VBD 10_1101-2021_01_06_425584 262 17 not not RB 10_1101-2021_01_06_425584 262 18 certified certify VBN 10_1101-2021_01_06_425584 262 19 by by IN 10_1101-2021_01_06_425584 262 20 peer peer NN 10_1101-2021_01_06_425584 262 21 review review NN 10_1101-2021_01_06_425584 262 22 ) ) -RRB- 10_1101-2021_01_06_425584 262 23 is be VBZ 10_1101-2021_01_06_425584 262 24 the the DT 10_1101-2021_01_06_425584 262 25 author author NN 10_1101-2021_01_06_425584 262 26 / / SYM 10_1101-2021_01_06_425584 262 27 funder funder NN 10_1101-2021_01_06_425584 262 28 , , , 10_1101-2021_01_06_425584 262 29 who who WP 10_1101-2021_01_06_425584 262 30 has have VBZ 10_1101-2021_01_06_425584 262 31 granted grant VBN 10_1101-2021_01_06_425584 262 32 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 262 33 a a DT 10_1101-2021_01_06_425584 262 34 license license NN 10_1101-2021_01_06_425584 262 35 to to TO 10_1101-2021_01_06_425584 262 36 display display VB 10_1101-2021_01_06_425584 262 37 the the DT 10_1101-2021_01_06_425584 262 38 preprint preprint NN 10_1101-2021_01_06_425584 262 39 in in IN 10_1101-2021_01_06_425584 262 40 perpetuity perpetuity NN 10_1101-2021_01_06_425584 262 41 . . . 10_1101-2021_01_06_425584 263 1 It -PRON- PRP 10_1101-2021_01_06_425584 263 2 is be VBZ 10_1101-2021_01_06_425584 263 3 made make VBN 10_1101-2021_01_06_425584 263 4 The the DT 10_1101-2021_01_06_425584 263 5 copyright copyright NN 10_1101-2021_01_06_425584 263 6 holder holder NN 10_1101-2021_01_06_425584 263 7 for for IN 10_1101-2021_01_06_425584 263 8 this this DT 10_1101-2021_01_06_425584 263 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 263 10 version version NN 10_1101-2021_01_06_425584 263 11 posted post VBD 10_1101-2021_01_06_425584 263 12 January January NNP 10_1101-2021_01_06_425584 263 13 8 8 CD 10_1101-2021_01_06_425584 263 14 , , , 10_1101-2021_01_06_425584 263 15 2021 2021 CD 10_1101-2021_01_06_425584 263 16 . . . 10_1101-2021_01_06_425584 263 17 ; ; : 10_1101-2021_01_06_425584 263 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 263 19 : : : 10_1101-2021_01_06_425584 263 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 263 21 preprint preprint NN 10_1101-2021_01_06_425584 263 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 263 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ RB 10_1101-2021_01_06_425584 263 24 16 16 CD 10_1101-2021_01_06_425584 263 25 We -PRON- PRP 10_1101-2021_01_06_425584 263 26 confirmed confirm VBD 10_1101-2021_01_06_425584 263 27 several several JJ 10_1101-2021_01_06_425584 263 28 independent independent JJ 10_1101-2021_01_06_425584 263 29 studies study NNS 10_1101-2021_01_06_425584 263 30 that that WDT 10_1101-2021_01_06_425584 263 31 reported report VBD 10_1101-2021_01_06_425584 263 32 alterations alteration NNS 10_1101-2021_01_06_425584 263 33 at at IN 10_1101-2021_01_06_425584 263 34 protein protein NN 10_1101-2021_01_06_425584 263 35 and and CC 10_1101-2021_01_06_425584 263 36 metabolite metabolite JJ 10_1101-2021_01_06_425584 263 37 492 492 CD 10_1101-2021_01_06_425584 263 38 levels level NNS 10_1101-2021_01_06_425584 263 39 in in IN 10_1101-2021_01_06_425584 263 40 endothelial endothelial JJ 10_1101-2021_01_06_425584 263 41 cells cell NNS 10_1101-2021_01_06_425584 263 42 of of IN 10_1101-2021_01_06_425584 263 43 different different JJ 10_1101-2021_01_06_425584 263 44 sources source NNS 10_1101-2021_01_06_425584 263 45 than than IN 10_1101-2021_01_06_425584 263 46 coronary coronary JJ 10_1101-2021_01_06_425584 263 47 vessels vessel NNS 10_1101-2021_01_06_425584 263 48 . . . 10_1101-2021_01_06_425584 264 1 Metabolomics metabolomic NNS 10_1101-2021_01_06_425584 264 2 , , , 10_1101-2021_01_06_425584 264 3 identified identify VBD 10_1101-2021_01_06_425584 264 4 493 493 CD 10_1101-2021_01_06_425584 264 5 alterations alteration NNS 10_1101-2021_01_06_425584 264 6 in in IN 10_1101-2021_01_06_425584 264 7 amino amino JJ 10_1101-2021_01_06_425584 264 8 acid acid NN 10_1101-2021_01_06_425584 264 9 , , , 10_1101-2021_01_06_425584 264 10 peptide peptide NN 10_1101-2021_01_06_425584 264 11 , , , 10_1101-2021_01_06_425584 264 12 and and CC 10_1101-2021_01_06_425584 264 13 phospholipid phospholipid NN 10_1101-2021_01_06_425584 264 14 metabolism metabolism NN 10_1101-2021_01_06_425584 264 15 . . . 10_1101-2021_01_06_425584 265 1 Notably notably RB 10_1101-2021_01_06_425584 265 2 , , , 10_1101-2021_01_06_425584 265 3 the the DT 10_1101-2021_01_06_425584 265 4 chemoinformatic chemoinformatic JJ 10_1101-2021_01_06_425584 265 5 494 494 CD 10_1101-2021_01_06_425584 265 6 analysis analysis NN 10_1101-2021_01_06_425584 265 7 identified identify VBD 10_1101-2021_01_06_425584 265 8 unreported unreported JJ 10_1101-2021_01_06_425584 265 9 alterations alteration NNS 10_1101-2021_01_06_425584 265 10 of of IN 10_1101-2021_01_06_425584 265 11 phenylalanine- phenylalanine- NN 10_1101-2021_01_06_425584 265 12 , , , 10_1101-2021_01_06_425584 265 13 glutathione- glutathione- NNP 10_1101-2021_01_06_425584 265 14 , , , 10_1101-2021_01_06_425584 265 15 and and CC 10_1101-2021_01_06_425584 265 16 proline proline NN 10_1101-2021_01_06_425584 265 17 - - HYPH 10_1101-2021_01_06_425584 265 18 based base VBN 10_1101-2021_01_06_425584 265 19 495 495 CD 10_1101-2021_01_06_425584 265 20 peptides peptide NNS 10_1101-2021_01_06_425584 265 21 on on IN 10_1101-2021_01_06_425584 265 22 coronary coronary JJ 10_1101-2021_01_06_425584 265 23 endothelium endothelium NN 10_1101-2021_01_06_425584 265 24 under under IN 10_1101-2021_01_06_425584 265 25 simulated simulate VBN 10_1101-2021_01_06_425584 265 26 diabetes diabete NNS 10_1101-2021_01_06_425584 265 27 . . . 10_1101-2021_01_06_425584 266 1 Proteomics proteomic NNS 10_1101-2021_01_06_425584 266 2 provided provide VBD 10_1101-2021_01_06_425584 266 3 evidence evidence NN 10_1101-2021_01_06_425584 266 4 of of IN 10_1101-2021_01_06_425584 266 5 496 496 CD 10_1101-2021_01_06_425584 266 6 reduced reduce VBN 10_1101-2021_01_06_425584 266 7 mitochondrial mitochondrial NN 10_1101-2021_01_06_425584 266 8 mass mass NN 10_1101-2021_01_06_425584 266 9 and and CC 10_1101-2021_01_06_425584 266 10 angiogenesis angiogenesis NN 10_1101-2021_01_06_425584 266 11 . . . 10_1101-2021_01_06_425584 267 1 The the DT 10_1101-2021_01_06_425584 267 2 integration integration NN 10_1101-2021_01_06_425584 267 3 of of IN 10_1101-2021_01_06_425584 267 4 proteomics proteomic NNS 10_1101-2021_01_06_425584 267 5 and and CC 10_1101-2021_01_06_425584 267 6 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 267 7 497 497 CD 10_1101-2021_01_06_425584 267 8 identified identify VBN 10_1101-2021_01_06_425584 267 9 increased increase VBN 10_1101-2021_01_06_425584 267 10 glutamic glutamic JJ 10_1101-2021_01_06_425584 267 11 acid acid NN 10_1101-2021_01_06_425584 267 12 metabolism metabolism NN 10_1101-2021_01_06_425584 267 13 and and CC 10_1101-2021_01_06_425584 267 14 suggested suggest VBD 10_1101-2021_01_06_425584 267 15 that that IN 10_1101-2021_01_06_425584 267 16 the the DT 10_1101-2021_01_06_425584 267 17 antioxidant antioxidant JJ 10_1101-2021_01_06_425584 267 18 enzymes enzyme NNS 10_1101-2021_01_06_425584 267 19 are be VBP 10_1101-2021_01_06_425584 267 20 498 498 CD 10_1101-2021_01_06_425584 267 21 involved involved JJ 10_1101-2021_01_06_425584 267 22 in in IN 10_1101-2021_01_06_425584 267 23 protecting protect VBG 10_1101-2021_01_06_425584 267 24 the the DT 10_1101-2021_01_06_425584 267 25 cells cell NNS 10_1101-2021_01_06_425584 267 26 from from IN 10_1101-2021_01_06_425584 267 27 oxidative oxidative JJ 10_1101-2021_01_06_425584 267 28 stress stress NN 10_1101-2021_01_06_425584 267 29 . . . 10_1101-2021_01_06_425584 268 1 Fluorescence fluorescence NN 10_1101-2021_01_06_425584 268 2 microscopy microscopy NN 10_1101-2021_01_06_425584 268 3 reported report VBD 10_1101-2021_01_06_425584 268 4 the the DT 10_1101-2021_01_06_425584 268 5 499 499 CD 10_1101-2021_01_06_425584 268 6 appearance appearance NN 10_1101-2021_01_06_425584 268 7 of of IN 10_1101-2021_01_06_425584 268 8 non non JJ 10_1101-2021_01_06_425584 268 9 - - JJ 10_1101-2021_01_06_425584 268 10 proliferative proliferative JJ 10_1101-2021_01_06_425584 268 11 binucleated binucleated JJ 10_1101-2021_01_06_425584 268 12 CAEC caec NN 10_1101-2021_01_06_425584 268 13 cells cell NNS 10_1101-2021_01_06_425584 268 14 as as IN 10_1101-2021_01_06_425584 268 15 a a DT 10_1101-2021_01_06_425584 268 16 mean mean NN 10_1101-2021_01_06_425584 268 17 to to TO 10_1101-2021_01_06_425584 268 18 metabolize metabolize VB 10_1101-2021_01_06_425584 268 19 the the DT 10_1101-2021_01_06_425584 268 20 excess excess NN 10_1101-2021_01_06_425584 268 21 of of IN 10_1101-2021_01_06_425584 268 22 500 500 CD 10_1101-2021_01_06_425584 268 23 ambient ambient JJ 10_1101-2021_01_06_425584 268 24 glucose glucose NN 10_1101-2021_01_06_425584 268 25 . . . 10_1101-2021_01_06_425584 269 1 Overall overall RB 10_1101-2021_01_06_425584 269 2 , , , 10_1101-2021_01_06_425584 269 3 our -PRON- PRP$ 10_1101-2021_01_06_425584 269 4 study study NN 10_1101-2021_01_06_425584 269 5 improved improve VBD 10_1101-2021_01_06_425584 269 6 the the DT 10_1101-2021_01_06_425584 269 7 understanding understanding NN 10_1101-2021_01_06_425584 269 8 of of IN 10_1101-2021_01_06_425584 269 9 the the DT 10_1101-2021_01_06_425584 269 10 molecular molecular JJ 10_1101-2021_01_06_425584 269 11 disturbances disturbance NNS 10_1101-2021_01_06_425584 269 12 501 501 CD 10_1101-2021_01_06_425584 269 13 caused cause VBN 10_1101-2021_01_06_425584 269 14 by by IN 10_1101-2021_01_06_425584 269 15 simulated simulated JJ 10_1101-2021_01_06_425584 269 16 diabetes diabete NNS 10_1101-2021_01_06_425584 269 17 that that WDT 10_1101-2021_01_06_425584 269 18 could could MD 10_1101-2021_01_06_425584 269 19 mediate mediate VB 10_1101-2021_01_06_425584 269 20 CAEC caec NN 10_1101-2021_01_06_425584 269 21 dysfunction dysfunction NN 10_1101-2021_01_06_425584 269 22 and and CC 10_1101-2021_01_06_425584 269 23 may may MD 10_1101-2021_01_06_425584 269 24 be be VB 10_1101-2021_01_06_425584 269 25 relevant relevant JJ 10_1101-2021_01_06_425584 269 26 in in IN 10_1101-2021_01_06_425584 269 27 the the DT 10_1101-2021_01_06_425584 269 28 502 502 CD 10_1101-2021_01_06_425584 269 29 context context NN 10_1101-2021_01_06_425584 269 30 of of IN 10_1101-2021_01_06_425584 269 31 CVD CVD NNP 10_1101-2021_01_06_425584 269 32 in in IN 10_1101-2021_01_06_425584 269 33 subjects subject NNS 10_1101-2021_01_06_425584 269 34 with with IN 10_1101-2021_01_06_425584 269 35 T2DM T2DM NNP 10_1101-2021_01_06_425584 269 36 . . . 10_1101-2021_01_06_425584 270 1 503 503 CD 10_1101-2021_01_06_425584 270 2 504 504 CD 10_1101-2021_01_06_425584 270 3 505 505 CD 10_1101-2021_01_06_425584 270 4 .CC .CC NFP 10_1101-2021_01_06_425584 270 5 - - HYPH 10_1101-2021_01_06_425584 270 6 BY by IN 10_1101-2021_01_06_425584 270 7 - - HYPH 10_1101-2021_01_06_425584 270 8 NC NC NNP 10_1101-2021_01_06_425584 270 9 - - HYPH 10_1101-2021_01_06_425584 270 10 ND ND NNP 10_1101-2021_01_06_425584 270 11 4.0 4.0 CD 10_1101-2021_01_06_425584 270 12 International International NNP 10_1101-2021_01_06_425584 270 13 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 270 14 under under IN 10_1101-2021_01_06_425584 270 15 a a DT 10_1101-2021_01_06_425584 270 16 ( ( -LRB- 10_1101-2021_01_06_425584 270 17 which which WDT 10_1101-2021_01_06_425584 270 18 was be VBD 10_1101-2021_01_06_425584 270 19 not not RB 10_1101-2021_01_06_425584 270 20 certified certify VBN 10_1101-2021_01_06_425584 270 21 by by IN 10_1101-2021_01_06_425584 270 22 peer peer NN 10_1101-2021_01_06_425584 270 23 review review NN 10_1101-2021_01_06_425584 270 24 ) ) -RRB- 10_1101-2021_01_06_425584 270 25 is be VBZ 10_1101-2021_01_06_425584 270 26 the the DT 10_1101-2021_01_06_425584 270 27 author author NN 10_1101-2021_01_06_425584 270 28 / / SYM 10_1101-2021_01_06_425584 270 29 funder funder NN 10_1101-2021_01_06_425584 270 30 , , , 10_1101-2021_01_06_425584 270 31 who who WP 10_1101-2021_01_06_425584 270 32 has have VBZ 10_1101-2021_01_06_425584 270 33 granted grant VBN 10_1101-2021_01_06_425584 270 34 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 270 35 a a DT 10_1101-2021_01_06_425584 270 36 license license NN 10_1101-2021_01_06_425584 270 37 to to TO 10_1101-2021_01_06_425584 270 38 display display VB 10_1101-2021_01_06_425584 270 39 the the DT 10_1101-2021_01_06_425584 270 40 preprint preprint NN 10_1101-2021_01_06_425584 270 41 in in IN 10_1101-2021_01_06_425584 270 42 perpetuity perpetuity NN 10_1101-2021_01_06_425584 270 43 . . . 10_1101-2021_01_06_425584 271 1 It -PRON- PRP 10_1101-2021_01_06_425584 271 2 is be VBZ 10_1101-2021_01_06_425584 271 3 made make VBN 10_1101-2021_01_06_425584 271 4 The the DT 10_1101-2021_01_06_425584 271 5 copyright copyright NN 10_1101-2021_01_06_425584 271 6 holder holder NN 10_1101-2021_01_06_425584 271 7 for for IN 10_1101-2021_01_06_425584 271 8 this this DT 10_1101-2021_01_06_425584 271 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 271 10 version version NN 10_1101-2021_01_06_425584 271 11 posted post VBD 10_1101-2021_01_06_425584 271 12 January January NNP 10_1101-2021_01_06_425584 271 13 8 8 CD 10_1101-2021_01_06_425584 271 14 , , , 10_1101-2021_01_06_425584 271 15 2021 2021 CD 10_1101-2021_01_06_425584 271 16 . . . 10_1101-2021_01_06_425584 271 17 ; ; : 10_1101-2021_01_06_425584 271 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 271 19 : : : 10_1101-2021_01_06_425584 271 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 271 21 preprint preprint NN 10_1101-2021_01_06_425584 271 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 271 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 271 24 17 17 CD 10_1101-2021_01_06_425584 271 25 5 5 CD 10_1101-2021_01_06_425584 271 26 . . . 10_1101-2021_01_06_425584 272 1 Acknowledgements acknowledgement NNS 10_1101-2021_01_06_425584 272 2 506 506 CD 10_1101-2021_01_06_425584 272 3 This this DT 10_1101-2021_01_06_425584 272 4 work work NN 10_1101-2021_01_06_425584 272 5 was be VBD 10_1101-2021_01_06_425584 272 6 derived derive VBN 10_1101-2021_01_06_425584 272 7 in in IN 10_1101-2021_01_06_425584 272 8 part part NN 10_1101-2021_01_06_425584 272 9 from from IN 10_1101-2021_01_06_425584 272 10 the the DT 10_1101-2021_01_06_425584 272 11 Thesis Thesis NNP 10_1101-2021_01_06_425584 272 12 Project Project NNP 10_1101-2021_01_06_425584 272 13 of of IN 10_1101-2021_01_06_425584 272 14 H.C.D.H. H.C.D.H. NNP 10_1101-2021_01_06_425584 273 1 at at IN 10_1101-2021_01_06_425584 273 2 the the DT 10_1101-2021_01_06_425584 273 3 Posgrado Posgrado NNP 10_1101-2021_01_06_425584 273 4 en en NNP 10_1101-2021_01_06_425584 273 5 507 507 CD 10_1101-2021_01_06_425584 273 6 Ciencias Ciencias NNP 10_1101-2021_01_06_425584 273 7 de de NNP 10_1101-2021_01_06_425584 273 8 la la NNP 10_1101-2021_01_06_425584 273 9 Vida Vida NNP 10_1101-2021_01_06_425584 273 10 , , , 10_1101-2021_01_06_425584 273 11 CICESE CICESE NNP 10_1101-2021_01_06_425584 273 12 . . . 10_1101-2021_01_06_425584 274 1 We -PRON- PRP 10_1101-2021_01_06_425584 274 2 thank thank VBP 10_1101-2021_01_06_425584 274 3 Alan Alan NNP 10_1101-2021_01_06_425584 274 4 G. G. NNP 10_1101-2021_01_06_425584 274 5 Hernández Hernández NNP 10_1101-2021_01_06_425584 274 6 - - HYPH 10_1101-2021_01_06_425584 274 7 Melgar Melgar NNP 10_1101-2021_01_06_425584 274 8 for for IN 10_1101-2021_01_06_425584 274 9 his -PRON- PRP$ 10_1101-2021_01_06_425584 274 10 invaluable invaluable JJ 10_1101-2021_01_06_425584 274 11 508 508 CD 10_1101-2021_01_06_425584 274 12 technical technical JJ 10_1101-2021_01_06_425584 274 13 assistance assistance NN 10_1101-2021_01_06_425584 274 14 with with IN 10_1101-2021_01_06_425584 274 15 the the DT 10_1101-2021_01_06_425584 274 16 NormalyzerDE NormalyzerDE NNP 10_1101-2021_01_06_425584 274 17 software software NN 10_1101-2021_01_06_425584 274 18 . . . 10_1101-2021_01_06_425584 275 1 509 509 CD 10_1101-2021_01_06_425584 275 2 510 510 CD 10_1101-2021_01_06_425584 275 3 511 511 CD 10_1101-2021_01_06_425584 275 4 512 512 CD 10_1101-2021_01_06_425584 275 5 513 513 CD 10_1101-2021_01_06_425584 275 6 514 514 CD 10_1101-2021_01_06_425584 275 7 515 515 CD 10_1101-2021_01_06_425584 275 8 .CC .CC : 10_1101-2021_01_06_425584 275 9 - - : 10_1101-2021_01_06_425584 275 10 BY by IN 10_1101-2021_01_06_425584 275 11 - - HYPH 10_1101-2021_01_06_425584 275 12 NC NC NNP 10_1101-2021_01_06_425584 275 13 - - HYPH 10_1101-2021_01_06_425584 275 14 ND ND NNP 10_1101-2021_01_06_425584 275 15 4.0 4.0 CD 10_1101-2021_01_06_425584 275 16 International International NNP 10_1101-2021_01_06_425584 275 17 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 275 18 under under IN 10_1101-2021_01_06_425584 275 19 a a DT 10_1101-2021_01_06_425584 275 20 ( ( -LRB- 10_1101-2021_01_06_425584 275 21 which which WDT 10_1101-2021_01_06_425584 275 22 was be VBD 10_1101-2021_01_06_425584 275 23 not not RB 10_1101-2021_01_06_425584 275 24 certified certify VBN 10_1101-2021_01_06_425584 275 25 by by IN 10_1101-2021_01_06_425584 275 26 peer peer NN 10_1101-2021_01_06_425584 275 27 review review NN 10_1101-2021_01_06_425584 275 28 ) ) -RRB- 10_1101-2021_01_06_425584 275 29 is be VBZ 10_1101-2021_01_06_425584 275 30 the the DT 10_1101-2021_01_06_425584 275 31 author author NN 10_1101-2021_01_06_425584 275 32 / / SYM 10_1101-2021_01_06_425584 275 33 funder funder NN 10_1101-2021_01_06_425584 275 34 , , , 10_1101-2021_01_06_425584 275 35 who who WP 10_1101-2021_01_06_425584 275 36 has have VBZ 10_1101-2021_01_06_425584 275 37 granted grant VBN 10_1101-2021_01_06_425584 275 38 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 275 39 a a DT 10_1101-2021_01_06_425584 275 40 license license NN 10_1101-2021_01_06_425584 275 41 to to TO 10_1101-2021_01_06_425584 275 42 display display VB 10_1101-2021_01_06_425584 275 43 the the DT 10_1101-2021_01_06_425584 275 44 preprint preprint NN 10_1101-2021_01_06_425584 275 45 in in IN 10_1101-2021_01_06_425584 275 46 perpetuity perpetuity NN 10_1101-2021_01_06_425584 275 47 . . . 10_1101-2021_01_06_425584 276 1 It -PRON- PRP 10_1101-2021_01_06_425584 276 2 is be VBZ 10_1101-2021_01_06_425584 276 3 made make VBN 10_1101-2021_01_06_425584 276 4 The the DT 10_1101-2021_01_06_425584 276 5 copyright copyright NN 10_1101-2021_01_06_425584 276 6 holder holder NN 10_1101-2021_01_06_425584 276 7 for for IN 10_1101-2021_01_06_425584 276 8 this this DT 10_1101-2021_01_06_425584 276 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 276 10 version version NN 10_1101-2021_01_06_425584 276 11 posted post VBD 10_1101-2021_01_06_425584 276 12 January January NNP 10_1101-2021_01_06_425584 276 13 8 8 CD 10_1101-2021_01_06_425584 276 14 , , , 10_1101-2021_01_06_425584 276 15 2021 2021 CD 10_1101-2021_01_06_425584 276 16 . . . 10_1101-2021_01_06_425584 276 17 ; ; : 10_1101-2021_01_06_425584 276 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 276 19 : : : 10_1101-2021_01_06_425584 276 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 276 21 preprint preprint NN 10_1101-2021_01_06_425584 276 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 276 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 276 24 18 18 CD 10_1101-2021_01_06_425584 276 25 6 6 CD 10_1101-2021_01_06_425584 276 26 . . . 10_1101-2021_01_06_425584 277 1 Funding fund VBG 10_1101-2021_01_06_425584 277 2 516 516 CD 10_1101-2021_01_06_425584 277 3 Part part NN 10_1101-2021_01_06_425584 277 4 of of IN 10_1101-2021_01_06_425584 277 5 this this DT 10_1101-2021_01_06_425584 277 6 work work NN 10_1101-2021_01_06_425584 277 7 was be VBD 10_1101-2021_01_06_425584 277 8 supported support VBN 10_1101-2021_01_06_425584 277 9 by by IN 10_1101-2021_01_06_425584 277 10 CICESE CICESE NNP 10_1101-2021_01_06_425584 277 11 ( ( -LRB- 10_1101-2021_01_06_425584 277 12 Grant Grant NNP 10_1101-2021_01_06_425584 277 13 No No NNP 10_1101-2021_01_06_425584 277 14 . . . 10_1101-2021_01_06_425584 278 1 685109 685109 CD 10_1101-2021_01_06_425584 278 2 to to IN 10_1101-2021_01_06_425584 278 3 AMU AMU NNP 10_1101-2021_01_06_425584 278 4 and and CC 10_1101-2021_01_06_425584 278 5 Internal Internal NNP 10_1101-2021_01_06_425584 278 6 517 517 CD 10_1101-2021_01_06_425584 278 7 Project Project NNP 10_1101-2021_01_06_425584 278 8 No no UH 10_1101-2021_01_06_425584 278 9 . . . 10_1101-2021_01_06_425584 279 1 685 685 CD 10_1101-2021_01_06_425584 279 2 - - SYM 10_1101-2021_01_06_425584 279 3 110 110 CD 10_1101-2021_01_06_425584 279 4 from from IN 10_1101-2021_01_06_425584 279 5 CAD CAD NNP 10_1101-2021_01_06_425584 279 6 ) ) -RRB- 10_1101-2021_01_06_425584 279 7 , , , 10_1101-2021_01_06_425584 279 8 NIH NIH NNP 10_1101-2021_01_06_425584 279 9 R01 R01 NNP 10_1101-2021_01_06_425584 279 10 DK98717 dk98717 NN 10_1101-2021_01_06_425584 279 11 ( ( -LRB- 10_1101-2021_01_06_425584 279 12 to to IN 10_1101-2021_01_06_425584 279 13 FV FV NNP 10_1101-2021_01_06_425584 279 14 ) ) -RRB- 10_1101-2021_01_06_425584 279 15 , , , 10_1101-2021_01_06_425584 279 16 and and CC 10_1101-2021_01_06_425584 279 17 VA VA NNP 10_1101-2021_01_06_425584 279 18 Merit Merit NNP 10_1101-2021_01_06_425584 279 19 - - HYPH 10_1101-2021_01_06_425584 279 20 I01 I01 NNP 10_1101-2021_01_06_425584 279 21 BX3230 bx3230 NN 10_1101-2021_01_06_425584 279 22 ( ( -LRB- 10_1101-2021_01_06_425584 279 23 to to IN 10_1101-2021_01_06_425584 279 24 518 518 CD 10_1101-2021_01_06_425584 279 25 FV FV NNP 10_1101-2021_01_06_425584 279 26 ) ) -RRB- 10_1101-2021_01_06_425584 279 27 . . . 10_1101-2021_01_06_425584 280 1 519 519 CD 10_1101-2021_01_06_425584 280 2 520 520 CD 10_1101-2021_01_06_425584 280 3 521 521 CD 10_1101-2021_01_06_425584 280 4 .CC .CC : 10_1101-2021_01_06_425584 280 5 - - HYPH 10_1101-2021_01_06_425584 280 6 BY by IN 10_1101-2021_01_06_425584 280 7 - - HYPH 10_1101-2021_01_06_425584 280 8 NC NC NNP 10_1101-2021_01_06_425584 280 9 - - HYPH 10_1101-2021_01_06_425584 280 10 ND ND NNP 10_1101-2021_01_06_425584 280 11 4.0 4.0 CD 10_1101-2021_01_06_425584 280 12 International International NNP 10_1101-2021_01_06_425584 280 13 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 280 14 under under IN 10_1101-2021_01_06_425584 280 15 a a DT 10_1101-2021_01_06_425584 280 16 ( ( -LRB- 10_1101-2021_01_06_425584 280 17 which which WDT 10_1101-2021_01_06_425584 280 18 was be VBD 10_1101-2021_01_06_425584 280 19 not not RB 10_1101-2021_01_06_425584 280 20 certified certify VBN 10_1101-2021_01_06_425584 280 21 by by IN 10_1101-2021_01_06_425584 280 22 peer peer NN 10_1101-2021_01_06_425584 280 23 review review NN 10_1101-2021_01_06_425584 280 24 ) ) -RRB- 10_1101-2021_01_06_425584 280 25 is be VBZ 10_1101-2021_01_06_425584 280 26 the the DT 10_1101-2021_01_06_425584 280 27 author author NN 10_1101-2021_01_06_425584 280 28 / / SYM 10_1101-2021_01_06_425584 280 29 funder funder NN 10_1101-2021_01_06_425584 280 30 , , , 10_1101-2021_01_06_425584 280 31 who who WP 10_1101-2021_01_06_425584 280 32 has have VBZ 10_1101-2021_01_06_425584 280 33 granted grant VBN 10_1101-2021_01_06_425584 280 34 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 280 35 a a DT 10_1101-2021_01_06_425584 280 36 license license NN 10_1101-2021_01_06_425584 280 37 to to TO 10_1101-2021_01_06_425584 280 38 display display VB 10_1101-2021_01_06_425584 280 39 the the DT 10_1101-2021_01_06_425584 280 40 preprint preprint NN 10_1101-2021_01_06_425584 280 41 in in IN 10_1101-2021_01_06_425584 280 42 perpetuity perpetuity NN 10_1101-2021_01_06_425584 280 43 . . . 10_1101-2021_01_06_425584 281 1 It -PRON- PRP 10_1101-2021_01_06_425584 281 2 is be VBZ 10_1101-2021_01_06_425584 281 3 made make VBN 10_1101-2021_01_06_425584 281 4 The the DT 10_1101-2021_01_06_425584 281 5 copyright copyright NN 10_1101-2021_01_06_425584 281 6 holder holder NN 10_1101-2021_01_06_425584 281 7 for for IN 10_1101-2021_01_06_425584 281 8 this this DT 10_1101-2021_01_06_425584 281 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 281 10 version version NN 10_1101-2021_01_06_425584 281 11 posted post VBD 10_1101-2021_01_06_425584 281 12 January January NNP 10_1101-2021_01_06_425584 281 13 8 8 CD 10_1101-2021_01_06_425584 281 14 , , , 10_1101-2021_01_06_425584 281 15 2021 2021 CD 10_1101-2021_01_06_425584 281 16 . . . 10_1101-2021_01_06_425584 281 17 ; ; : 10_1101-2021_01_06_425584 281 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 281 19 : : : 10_1101-2021_01_06_425584 281 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 281 21 preprint preprint NN 10_1101-2021_01_06_425584 281 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 281 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 281 24 19 19 CD 10_1101-2021_01_06_425584 281 25 7 7 CD 10_1101-2021_01_06_425584 281 26 . . . 10_1101-2021_01_06_425584 282 1 Conflict conflict NN 10_1101-2021_01_06_425584 282 2 of of IN 10_1101-2021_01_06_425584 282 3 interest interest NN 10_1101-2021_01_06_425584 282 4 522 522 CD 10_1101-2021_01_06_425584 282 5 Dr. Dr. NNP 10_1101-2021_01_06_425584 282 6 Villarreal Villarreal NNP 10_1101-2021_01_06_425584 282 7 is be VBZ 10_1101-2021_01_06_425584 282 8 a a DT 10_1101-2021_01_06_425584 282 9 co co NN 10_1101-2021_01_06_425584 282 10 - - NN 10_1101-2021_01_06_425584 282 11 founder founder NN 10_1101-2021_01_06_425584 282 12 and and CC 10_1101-2021_01_06_425584 282 13 stockholder stockholder NN 10_1101-2021_01_06_425584 282 14 of of IN 10_1101-2021_01_06_425584 282 15 Cardero Cardero NNP 10_1101-2021_01_06_425584 282 16 Therapeutics Therapeutics NNP 10_1101-2021_01_06_425584 282 17 , , , 10_1101-2021_01_06_425584 282 18 Inc. Inc. NNP 10_1101-2021_01_06_425584 282 19 523 523 CD 10_1101-2021_01_06_425584 282 20 524 524 CD 10_1101-2021_01_06_425584 282 21 525 525 CD 10_1101-2021_01_06_425584 282 22 .CC .CC : 10_1101-2021_01_06_425584 282 23 - - HYPH 10_1101-2021_01_06_425584 282 24 BY by IN 10_1101-2021_01_06_425584 282 25 - - HYPH 10_1101-2021_01_06_425584 282 26 NC NC NNP 10_1101-2021_01_06_425584 282 27 - - HYPH 10_1101-2021_01_06_425584 282 28 ND ND NNP 10_1101-2021_01_06_425584 282 29 4.0 4.0 CD 10_1101-2021_01_06_425584 282 30 International International NNP 10_1101-2021_01_06_425584 282 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 282 32 under under IN 10_1101-2021_01_06_425584 282 33 a a DT 10_1101-2021_01_06_425584 282 34 ( ( -LRB- 10_1101-2021_01_06_425584 282 35 which which WDT 10_1101-2021_01_06_425584 282 36 was be VBD 10_1101-2021_01_06_425584 282 37 not not RB 10_1101-2021_01_06_425584 282 38 certified certify VBN 10_1101-2021_01_06_425584 282 39 by by IN 10_1101-2021_01_06_425584 282 40 peer peer NN 10_1101-2021_01_06_425584 282 41 review review NN 10_1101-2021_01_06_425584 282 42 ) ) -RRB- 10_1101-2021_01_06_425584 282 43 is be VBZ 10_1101-2021_01_06_425584 282 44 the the DT 10_1101-2021_01_06_425584 282 45 author author NN 10_1101-2021_01_06_425584 282 46 / / SYM 10_1101-2021_01_06_425584 282 47 funder funder NN 10_1101-2021_01_06_425584 282 48 , , , 10_1101-2021_01_06_425584 282 49 who who WP 10_1101-2021_01_06_425584 282 50 has have VBZ 10_1101-2021_01_06_425584 282 51 granted grant VBN 10_1101-2021_01_06_425584 282 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 282 53 a a DT 10_1101-2021_01_06_425584 282 54 license license NN 10_1101-2021_01_06_425584 282 55 to to TO 10_1101-2021_01_06_425584 282 56 display display VB 10_1101-2021_01_06_425584 282 57 the the DT 10_1101-2021_01_06_425584 282 58 preprint preprint NN 10_1101-2021_01_06_425584 282 59 in in IN 10_1101-2021_01_06_425584 282 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 282 61 . . . 10_1101-2021_01_06_425584 283 1 It -PRON- PRP 10_1101-2021_01_06_425584 283 2 is be VBZ 10_1101-2021_01_06_425584 283 3 made make VBN 10_1101-2021_01_06_425584 283 4 The the DT 10_1101-2021_01_06_425584 283 5 copyright copyright NN 10_1101-2021_01_06_425584 283 6 holder holder NN 10_1101-2021_01_06_425584 283 7 for for IN 10_1101-2021_01_06_425584 283 8 this this DT 10_1101-2021_01_06_425584 283 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 283 10 version version NN 10_1101-2021_01_06_425584 283 11 posted post VBD 10_1101-2021_01_06_425584 283 12 January January NNP 10_1101-2021_01_06_425584 283 13 8 8 CD 10_1101-2021_01_06_425584 283 14 , , , 10_1101-2021_01_06_425584 283 15 2021 2021 CD 10_1101-2021_01_06_425584 283 16 . . . 10_1101-2021_01_06_425584 283 17 ; ; : 10_1101-2021_01_06_425584 283 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 283 19 : : : 10_1101-2021_01_06_425584 283 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 283 21 preprint preprint NN 10_1101-2021_01_06_425584 283 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 283 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 283 24 20 20 CD 10_1101-2021_01_06_425584 283 25 8 8 CD 10_1101-2021_01_06_425584 283 26 . . . 10_1101-2021_01_06_425584 284 1 Author author NN 10_1101-2021_01_06_425584 284 2 contributions contribution NNS 10_1101-2021_01_06_425584 284 3 526 526 CD 10_1101-2021_01_06_425584 284 4 A.M.U. A.M.U. NNP 10_1101-2021_01_06_425584 285 1 contributed contribute VBD 10_1101-2021_01_06_425584 285 2 to to IN 10_1101-2021_01_06_425584 285 3 the the DT 10_1101-2021_01_06_425584 285 4 study study NN 10_1101-2021_01_06_425584 285 5 conception conception NN 10_1101-2021_01_06_425584 285 6 and and CC 10_1101-2021_01_06_425584 285 7 design design NN 10_1101-2021_01_06_425584 285 8 , , , 10_1101-2021_01_06_425584 285 9 data datum NNS 10_1101-2021_01_06_425584 285 10 acquisition acquisition NN 10_1101-2021_01_06_425584 285 11 , , , 10_1101-2021_01_06_425584 285 12 formal formal JJ 10_1101-2021_01_06_425584 285 13 analysis analysis NN 10_1101-2021_01_06_425584 285 14 , , , 10_1101-2021_01_06_425584 285 15 527 527 CD 10_1101-2021_01_06_425584 285 16 methodology methodology NN 10_1101-2021_01_06_425584 285 17 , , , 10_1101-2021_01_06_425584 285 18 project project NN 10_1101-2021_01_06_425584 285 19 administration administration NN 10_1101-2021_01_06_425584 285 20 , , , 10_1101-2021_01_06_425584 285 21 and and CC 10_1101-2021_01_06_425584 285 22 funding funding NN 10_1101-2021_01_06_425584 285 23 acquisition acquisition NN 10_1101-2021_01_06_425584 285 24 . . . 10_1101-2021_01_06_425584 286 1 H.C.D.H. H.C.D.H. NNP 10_1101-2021_01_06_425584 286 2 , , , 10_1101-2021_01_06_425584 286 3 L.D.M L.D.M NNP 10_1101-2021_01_06_425584 286 4 , , , 10_1101-2021_01_06_425584 286 5 and and CC 10_1101-2021_01_06_425584 286 6 R.A.C.C. R.A.C.C. NNP 10_1101-2021_01_06_425584 287 1 528 528 CD 10_1101-2021_01_06_425584 287 2 contributed contribute VBN 10_1101-2021_01_06_425584 287 3 to to IN 10_1101-2021_01_06_425584 287 4 the the DT 10_1101-2021_01_06_425584 287 5 data datum NNS 10_1101-2021_01_06_425584 287 6 acquisition acquisition NN 10_1101-2021_01_06_425584 287 7 , , , 10_1101-2021_01_06_425584 287 8 formal formal JJ 10_1101-2021_01_06_425584 287 9 analysis analysis NN 10_1101-2021_01_06_425584 287 10 and and CC 10_1101-2021_01_06_425584 287 11 interpretation interpretation NN 10_1101-2021_01_06_425584 287 12 of of IN 10_1101-2021_01_06_425584 287 13 some some DT 10_1101-2021_01_06_425584 287 14 experiments experiment NNS 10_1101-2021_01_06_425584 287 15 . . . 10_1101-2021_01_06_425584 288 1 529 529 CD 10_1101-2021_01_06_425584 288 2 C.A.D. C.A.D. NNP 10_1101-2021_01_06_425584 288 3 , , , 10_1101-2021_01_06_425584 288 4 and and CC 10_1101-2021_01_06_425584 288 5 F.V. F.V. NNP 10_1101-2021_01_06_425584 289 1 contributed contribute VBD 10_1101-2021_01_06_425584 289 2 to to IN 10_1101-2021_01_06_425584 289 3 funding funding NN 10_1101-2021_01_06_425584 289 4 acquisition acquisition NN 10_1101-2021_01_06_425584 289 5 and and CC 10_1101-2021_01_06_425584 289 6 resources resource NNS 10_1101-2021_01_06_425584 289 7 . . . 10_1101-2021_01_06_425584 290 1 O.M.P O.M.P NNP 10_1101-2021_01_06_425584 290 2 contributed contribute VBD 10_1101-2021_01_06_425584 290 3 to to IN 10_1101-2021_01_06_425584 290 4 data datum NNS 10_1101-2021_01_06_425584 290 5 530 530 CD 10_1101-2021_01_06_425584 290 6 interpretation interpretation NN 10_1101-2021_01_06_425584 290 7 and and CC 10_1101-2021_01_06_425584 290 8 critical critical JJ 10_1101-2021_01_06_425584 290 9 revision revision NN 10_1101-2021_01_06_425584 290 10 of of IN 10_1101-2021_01_06_425584 290 11 manuscript manuscript NN 10_1101-2021_01_06_425584 290 12 . . . 10_1101-2021_01_06_425584 291 1 All all DT 10_1101-2021_01_06_425584 291 2 authors author NNS 10_1101-2021_01_06_425584 291 3 contributed contribute VBD 10_1101-2021_01_06_425584 291 4 to to IN 10_1101-2021_01_06_425584 291 5 the the DT 10_1101-2021_01_06_425584 291 6 drafting drafting NN 10_1101-2021_01_06_425584 291 7 , , , 10_1101-2021_01_06_425584 291 8 revising revise VBG 10_1101-2021_01_06_425584 291 9 , , , 10_1101-2021_01_06_425584 291 10 531 531 CD 10_1101-2021_01_06_425584 291 11 and and CC 10_1101-2021_01_06_425584 291 12 approval approval NN 10_1101-2021_01_06_425584 291 13 of of IN 10_1101-2021_01_06_425584 291 14 the the DT 10_1101-2021_01_06_425584 291 15 final final JJ 10_1101-2021_01_06_425584 291 16 version version NN 10_1101-2021_01_06_425584 291 17 of of IN 10_1101-2021_01_06_425584 291 18 the the DT 10_1101-2021_01_06_425584 291 19 manuscript manuscript NN 10_1101-2021_01_06_425584 291 20 . . . 10_1101-2021_01_06_425584 292 1 532 532 CD 10_1101-2021_01_06_425584 292 2 533 533 CD 10_1101-2021_01_06_425584 292 3 .CC .CC : 10_1101-2021_01_06_425584 292 4 - - HYPH 10_1101-2021_01_06_425584 292 5 BY by IN 10_1101-2021_01_06_425584 292 6 - - HYPH 10_1101-2021_01_06_425584 292 7 NC NC NNP 10_1101-2021_01_06_425584 292 8 - - HYPH 10_1101-2021_01_06_425584 292 9 ND ND NNP 10_1101-2021_01_06_425584 292 10 4.0 4.0 CD 10_1101-2021_01_06_425584 292 11 International International NNP 10_1101-2021_01_06_425584 292 12 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 292 13 under under IN 10_1101-2021_01_06_425584 292 14 a a DT 10_1101-2021_01_06_425584 292 15 ( ( -LRB- 10_1101-2021_01_06_425584 292 16 which which WDT 10_1101-2021_01_06_425584 292 17 was be VBD 10_1101-2021_01_06_425584 292 18 not not RB 10_1101-2021_01_06_425584 292 19 certified certify VBN 10_1101-2021_01_06_425584 292 20 by by IN 10_1101-2021_01_06_425584 292 21 peer peer NN 10_1101-2021_01_06_425584 292 22 review review NN 10_1101-2021_01_06_425584 292 23 ) ) -RRB- 10_1101-2021_01_06_425584 292 24 is be VBZ 10_1101-2021_01_06_425584 292 25 the the DT 10_1101-2021_01_06_425584 292 26 author author NN 10_1101-2021_01_06_425584 292 27 / / SYM 10_1101-2021_01_06_425584 292 28 funder funder NN 10_1101-2021_01_06_425584 292 29 , , , 10_1101-2021_01_06_425584 292 30 who who WP 10_1101-2021_01_06_425584 292 31 has have VBZ 10_1101-2021_01_06_425584 292 32 granted grant VBN 10_1101-2021_01_06_425584 292 33 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 292 34 a a DT 10_1101-2021_01_06_425584 292 35 license license NN 10_1101-2021_01_06_425584 292 36 to to TO 10_1101-2021_01_06_425584 292 37 display display VB 10_1101-2021_01_06_425584 292 38 the the DT 10_1101-2021_01_06_425584 292 39 preprint preprint NN 10_1101-2021_01_06_425584 292 40 in in IN 10_1101-2021_01_06_425584 292 41 perpetuity perpetuity NN 10_1101-2021_01_06_425584 292 42 . . . 10_1101-2021_01_06_425584 293 1 It -PRON- PRP 10_1101-2021_01_06_425584 293 2 is be VBZ 10_1101-2021_01_06_425584 293 3 made make VBN 10_1101-2021_01_06_425584 293 4 The the DT 10_1101-2021_01_06_425584 293 5 copyright copyright NN 10_1101-2021_01_06_425584 293 6 holder holder NN 10_1101-2021_01_06_425584 293 7 for for IN 10_1101-2021_01_06_425584 293 8 this this DT 10_1101-2021_01_06_425584 293 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 293 10 version version NN 10_1101-2021_01_06_425584 293 11 posted post VBD 10_1101-2021_01_06_425584 293 12 January January NNP 10_1101-2021_01_06_425584 293 13 8 8 CD 10_1101-2021_01_06_425584 293 14 , , , 10_1101-2021_01_06_425584 293 15 2021 2021 CD 10_1101-2021_01_06_425584 293 16 . . . 10_1101-2021_01_06_425584 293 17 ; ; : 10_1101-2021_01_06_425584 293 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 293 19 : : : 10_1101-2021_01_06_425584 293 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 293 21 preprint preprint NN 10_1101-2021_01_06_425584 293 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 293 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ RB 10_1101-2021_01_06_425584 293 24 21 21 CD 10_1101-2021_01_06_425584 293 25 References reference NNS 10_1101-2021_01_06_425584 293 26 534 534 CD 10_1101-2021_01_06_425584 293 27 535 535 CD 10_1101-2021_01_06_425584 293 28 1 1 CD 10_1101-2021_01_06_425584 293 29 . . . 10_1101-2021_01_06_425584 294 1 Halcox Halcox NNP 10_1101-2021_01_06_425584 294 2 , , , 10_1101-2021_01_06_425584 294 3 J. J. NNP 10_1101-2021_01_06_425584 294 4 P. P. NNP 10_1101-2021_01_06_425584 294 5 ; ; : 10_1101-2021_01_06_425584 294 6 Schenke Schenke NNP 10_1101-2021_01_06_425584 294 7 , , , 10_1101-2021_01_06_425584 294 8 W. W. NNP 10_1101-2021_01_06_425584 294 9 H. H. NNP 10_1101-2021_01_06_425584 294 10 ; ; : 10_1101-2021_01_06_425584 294 11 Zalos Zalos NNP 10_1101-2021_01_06_425584 294 12 , , , 10_1101-2021_01_06_425584 294 13 G. G. NNP 10_1101-2021_01_06_425584 294 14 ; ; : 10_1101-2021_01_06_425584 294 15 Mincemoyer Mincemoyer NNP 10_1101-2021_01_06_425584 294 16 , , , 10_1101-2021_01_06_425584 294 17 R. R. NNP 10_1101-2021_01_06_425584 294 18 ; ; : 10_1101-2021_01_06_425584 294 19 Prasad Prasad NNP 10_1101-2021_01_06_425584 294 20 , , , 10_1101-2021_01_06_425584 294 21 A. a. NN 10_1101-2021_01_06_425584 294 22 ; ; : 10_1101-2021_01_06_425584 294 23 Waclawiw Waclawiw NNP 10_1101-2021_01_06_425584 294 24 , , , 10_1101-2021_01_06_425584 294 25 M. M. NNP 10_1101-2021_01_06_425584 294 26 A. A. NNP 10_1101-2021_01_06_425584 294 27 ; ; : 10_1101-2021_01_06_425584 294 28 536 536 CD 10_1101-2021_01_06_425584 294 29 Nour Nour NNP 10_1101-2021_01_06_425584 294 30 , , , 10_1101-2021_01_06_425584 294 31 K. K. NNP 10_1101-2021_01_06_425584 294 32 R. R. NNP 10_1101-2021_01_06_425584 294 33 ; ; : 10_1101-2021_01_06_425584 294 34 Quyyumi Quyyumi NNP 10_1101-2021_01_06_425584 294 35 , , , 10_1101-2021_01_06_425584 294 36 A. a. NN 10_1101-2021_01_06_425584 295 1 A. a. LS 10_1101-2021_01_06_425584 295 2 , , , 10_1101-2021_01_06_425584 295 3 Prognostic prognostic JJ 10_1101-2021_01_06_425584 295 4 value value NN 10_1101-2021_01_06_425584 295 5 of of IN 10_1101-2021_01_06_425584 295 6 coronary coronary JJ 10_1101-2021_01_06_425584 295 7 vascular vascular JJ 10_1101-2021_01_06_425584 295 8 endothelial endothelial JJ 10_1101-2021_01_06_425584 295 9 dysfunction dysfunction NN 10_1101-2021_01_06_425584 295 10 . . . 10_1101-2021_01_06_425584 296 1 537 537 CD 10_1101-2021_01_06_425584 296 2 Circulation Circulation NNP 10_1101-2021_01_06_425584 296 3 2002 2002 CD 10_1101-2021_01_06_425584 296 4 , , , 10_1101-2021_01_06_425584 296 5 106 106 CD 10_1101-2021_01_06_425584 296 6 , , , 10_1101-2021_01_06_425584 296 7 ( ( -LRB- 10_1101-2021_01_06_425584 296 8 6 6 CD 10_1101-2021_01_06_425584 296 9 ) ) -RRB- 10_1101-2021_01_06_425584 296 10 , , , 10_1101-2021_01_06_425584 296 11 653 653 CD 10_1101-2021_01_06_425584 296 12 - - SYM 10_1101-2021_01_06_425584 296 13 8 8 CD 10_1101-2021_01_06_425584 296 14 . . . 10_1101-2021_01_06_425584 297 1 538 538 CD 10_1101-2021_01_06_425584 297 2 2 2 CD 10_1101-2021_01_06_425584 297 3 . . . 10_1101-2021_01_06_425584 298 1 Lind Lind NNP 10_1101-2021_01_06_425584 298 2 , , , 10_1101-2021_01_06_425584 298 3 M. M. NNP 10_1101-2021_01_06_425584 298 4 ; ; : 10_1101-2021_01_06_425584 298 5 Wedel Wedel NNP 10_1101-2021_01_06_425584 298 6 , , , 10_1101-2021_01_06_425584 298 7 H. H. NNP 10_1101-2021_01_06_425584 298 8 ; ; : 10_1101-2021_01_06_425584 298 9 Rosengren Rosengren NNP 10_1101-2021_01_06_425584 298 10 , , , 10_1101-2021_01_06_425584 298 11 A. a. NN 10_1101-2021_01_06_425584 298 12 , , , 10_1101-2021_01_06_425584 298 13 Excess Excess NNP 10_1101-2021_01_06_425584 298 14 Mortality mortality NN 10_1101-2021_01_06_425584 298 15 among among IN 10_1101-2021_01_06_425584 298 16 Persons Persons NNPS 10_1101-2021_01_06_425584 298 17 with with IN 10_1101-2021_01_06_425584 298 18 Type Type NNP 10_1101-2021_01_06_425584 298 19 2 2 CD 10_1101-2021_01_06_425584 298 20 539 539 CD 10_1101-2021_01_06_425584 298 21 Diabetes diabete NNS 10_1101-2021_01_06_425584 298 22 . . . 10_1101-2021_01_06_425584 299 1 N N NNP 10_1101-2021_01_06_425584 299 2 Engl Engl NNP 10_1101-2021_01_06_425584 299 3 J J NNP 10_1101-2021_01_06_425584 299 4 Med Med NNP 10_1101-2021_01_06_425584 299 5 2016 2016 CD 10_1101-2021_01_06_425584 299 6 , , , 10_1101-2021_01_06_425584 299 7 374 374 CD 10_1101-2021_01_06_425584 299 8 , , , 10_1101-2021_01_06_425584 299 9 ( ( -LRB- 10_1101-2021_01_06_425584 299 10 8) 8) CD 10_1101-2021_01_06_425584 299 11 , , , 10_1101-2021_01_06_425584 299 12 788 788 CD 10_1101-2021_01_06_425584 299 13 - - SYM 10_1101-2021_01_06_425584 299 14 9 9 CD 10_1101-2021_01_06_425584 299 15 . . . 10_1101-2021_01_06_425584 300 1 540 540 CD 10_1101-2021_01_06_425584 300 2 3 3 CD 10_1101-2021_01_06_425584 300 3 . . . 10_1101-2021_01_06_425584 301 1 Gutierrez Gutierrez NNP 10_1101-2021_01_06_425584 301 2 , , , 10_1101-2021_01_06_425584 301 3 E. E. NNP 10_1101-2021_01_06_425584 301 4 ; ; : 10_1101-2021_01_06_425584 301 5 Flammer Flammer NNP 10_1101-2021_01_06_425584 301 6 , , , 10_1101-2021_01_06_425584 301 7 A. A. NNP 10_1101-2021_01_06_425584 301 8 J. J. NNP 10_1101-2021_01_06_425584 301 9 ; ; : 10_1101-2021_01_06_425584 301 10 Lerman Lerman NNP 10_1101-2021_01_06_425584 301 11 , , , 10_1101-2021_01_06_425584 301 12 L. L. NNP 10_1101-2021_01_06_425584 301 13 O. O. NNP 10_1101-2021_01_06_425584 301 14 ; ; : 10_1101-2021_01_06_425584 301 15 Elizaga Elizaga NNP 10_1101-2021_01_06_425584 301 16 , , , 10_1101-2021_01_06_425584 301 17 J. J. NNP 10_1101-2021_01_06_425584 301 18 ; ; : 10_1101-2021_01_06_425584 301 19 Lerman Lerman NNP 10_1101-2021_01_06_425584 301 20 , , , 10_1101-2021_01_06_425584 301 21 A. a. NN 10_1101-2021_01_06_425584 301 22 ; ; : 10_1101-2021_01_06_425584 301 23 Fernandez Fernandez NNP 10_1101-2021_01_06_425584 301 24 - - HYPH 10_1101-2021_01_06_425584 301 25 Aviles Aviles NNP 10_1101-2021_01_06_425584 301 26 , , , 10_1101-2021_01_06_425584 301 27 541 541 CD 10_1101-2021_01_06_425584 301 28 F. F. NNP 10_1101-2021_01_06_425584 301 29 , , , 10_1101-2021_01_06_425584 301 30 Endothelial endothelial JJ 10_1101-2021_01_06_425584 301 31 dysfunction dysfunction NN 10_1101-2021_01_06_425584 301 32 over over IN 10_1101-2021_01_06_425584 301 33 the the DT 10_1101-2021_01_06_425584 301 34 course course NN 10_1101-2021_01_06_425584 301 35 of of IN 10_1101-2021_01_06_425584 301 36 coronary coronary JJ 10_1101-2021_01_06_425584 301 37 artery artery NN 10_1101-2021_01_06_425584 301 38 disease disease NN 10_1101-2021_01_06_425584 301 39 . . . 10_1101-2021_01_06_425584 302 1 Eur Eur NNP 10_1101-2021_01_06_425584 302 2 Heart Heart NNP 10_1101-2021_01_06_425584 302 3 J J NNP 10_1101-2021_01_06_425584 302 4 2013 2013 CD 10_1101-2021_01_06_425584 302 5 , , , 10_1101-2021_01_06_425584 302 6 34 34 CD 10_1101-2021_01_06_425584 302 7 , , , 10_1101-2021_01_06_425584 302 8 542 542 CD 10_1101-2021_01_06_425584 302 9 ( ( -LRB- 10_1101-2021_01_06_425584 302 10 41 41 CD 10_1101-2021_01_06_425584 302 11 ) ) -RRB- 10_1101-2021_01_06_425584 302 12 , , , 10_1101-2021_01_06_425584 302 13 3175 3175 CD 10_1101-2021_01_06_425584 302 14 - - SYM 10_1101-2021_01_06_425584 302 15 81 81 CD 10_1101-2021_01_06_425584 302 16 . . . 10_1101-2021_01_06_425584 303 1 543 543 CD 10_1101-2021_01_06_425584 303 2 4 4 CD 10_1101-2021_01_06_425584 303 3 . . . 10_1101-2021_01_06_425584 304 1 Lorenzi Lorenzi NNP 10_1101-2021_01_06_425584 304 2 , , , 10_1101-2021_01_06_425584 304 3 M. M. NNP 10_1101-2021_01_06_425584 304 4 ; ; : 10_1101-2021_01_06_425584 304 5 Cagliero Cagliero NNP 10_1101-2021_01_06_425584 304 6 , , , 10_1101-2021_01_06_425584 304 7 E. E. NNP 10_1101-2021_01_06_425584 304 8 ; ; : 10_1101-2021_01_06_425584 304 9 Toledo Toledo NNP 10_1101-2021_01_06_425584 304 10 , , , 10_1101-2021_01_06_425584 304 11 S. S. NNP 10_1101-2021_01_06_425584 304 12 , , , 10_1101-2021_01_06_425584 304 13 Glucose Glucose NNP 10_1101-2021_01_06_425584 304 14 toxicity toxicity NN 10_1101-2021_01_06_425584 304 15 for for IN 10_1101-2021_01_06_425584 304 16 human human JJ 10_1101-2021_01_06_425584 304 17 endothelial endothelial JJ 10_1101-2021_01_06_425584 304 18 cells cell NNS 10_1101-2021_01_06_425584 304 19 in in IN 10_1101-2021_01_06_425584 304 20 544 544 CD 10_1101-2021_01_06_425584 304 21 culture culture NN 10_1101-2021_01_06_425584 304 22 . . . 10_1101-2021_01_06_425584 305 1 Delayed delay VBN 10_1101-2021_01_06_425584 305 2 replication replication NN 10_1101-2021_01_06_425584 305 3 , , , 10_1101-2021_01_06_425584 305 4 disturbed disturbed JJ 10_1101-2021_01_06_425584 305 5 cell cell NN 10_1101-2021_01_06_425584 305 6 cycle cycle NN 10_1101-2021_01_06_425584 305 7 , , , 10_1101-2021_01_06_425584 305 8 and and CC 10_1101-2021_01_06_425584 305 9 accelerated accelerate VBD 10_1101-2021_01_06_425584 305 10 death death NN 10_1101-2021_01_06_425584 305 11 . . . 10_1101-2021_01_06_425584 306 1 Diabetes diabetes NN 10_1101-2021_01_06_425584 306 2 1985 1985 CD 10_1101-2021_01_06_425584 306 3 , , , 10_1101-2021_01_06_425584 306 4 34 34 CD 10_1101-2021_01_06_425584 306 5 , , , 10_1101-2021_01_06_425584 306 6 ( ( -LRB- 10_1101-2021_01_06_425584 306 7 7 7 CD 10_1101-2021_01_06_425584 306 8 ) ) -RRB- 10_1101-2021_01_06_425584 306 9 , , , 10_1101-2021_01_06_425584 306 10 545 545 CD 10_1101-2021_01_06_425584 306 11 621 621 CD 10_1101-2021_01_06_425584 306 12 - - SYM 10_1101-2021_01_06_425584 306 13 7 7 CD 10_1101-2021_01_06_425584 306 14 . . . 10_1101-2021_01_06_425584 307 1 546 546 CD 10_1101-2021_01_06_425584 307 2 5 5 CD 10_1101-2021_01_06_425584 307 3 . . . 10_1101-2021_01_06_425584 308 1 Kageyama Kageyama NNP 10_1101-2021_01_06_425584 308 2 , , , 10_1101-2021_01_06_425584 308 3 S. S. NNP 10_1101-2021_01_06_425584 308 4 ; ; : 10_1101-2021_01_06_425584 308 5 Yokoo Yokoo NNP 10_1101-2021_01_06_425584 308 6 , , , 10_1101-2021_01_06_425584 308 7 H. H. NNP 10_1101-2021_01_06_425584 308 8 ; ; : 10_1101-2021_01_06_425584 308 9 Tomita Tomita NNP 10_1101-2021_01_06_425584 308 10 , , , 10_1101-2021_01_06_425584 308 11 K. K. NNP 10_1101-2021_01_06_425584 308 12 ; ; : 10_1101-2021_01_06_425584 308 13 Kageyama Kageyama NNP 10_1101-2021_01_06_425584 308 14 - - HYPH 10_1101-2021_01_06_425584 308 15 Yahara Yahara NNP 10_1101-2021_01_06_425584 308 16 , , , 10_1101-2021_01_06_425584 308 17 N. N. NNP 10_1101-2021_01_06_425584 308 18 ; ; : 10_1101-2021_01_06_425584 308 19 Uchimido Uchimido NNP 10_1101-2021_01_06_425584 308 20 , , , 10_1101-2021_01_06_425584 308 21 R. R. NNP 10_1101-2021_01_06_425584 308 22 ; ; : 10_1101-2021_01_06_425584 308 23 Matsuda Matsuda NNP 10_1101-2021_01_06_425584 308 24 , , , 10_1101-2021_01_06_425584 308 25 547 547 CD 10_1101-2021_01_06_425584 308 26 N. n. NN 10_1101-2021_01_06_425584 308 27 ; ; : 10_1101-2021_01_06_425584 308 28 Yamamoto Yamamoto NNP 10_1101-2021_01_06_425584 308 29 , , , 10_1101-2021_01_06_425584 308 30 S. S. NNP 10_1101-2021_01_06_425584 308 31 ; ; : 10_1101-2021_01_06_425584 308 32 Hattori Hattori NNP 10_1101-2021_01_06_425584 308 33 , , , 10_1101-2021_01_06_425584 308 34 Y. Y. NNP 10_1101-2021_01_06_425584 308 35 , , , 10_1101-2021_01_06_425584 308 36 High high JJ 10_1101-2021_01_06_425584 308 37 glucose glucose NN 10_1101-2021_01_06_425584 308 38 - - HYPH 10_1101-2021_01_06_425584 308 39 induced induce VBN 10_1101-2021_01_06_425584 308 40 apoptosis apoptosis NN 10_1101-2021_01_06_425584 308 41 in in IN 10_1101-2021_01_06_425584 308 42 human human JJ 10_1101-2021_01_06_425584 308 43 coronary coronary JJ 10_1101-2021_01_06_425584 308 44 artery artery NN 10_1101-2021_01_06_425584 308 45 548 548 CD 10_1101-2021_01_06_425584 308 46 endothelial endothelial JJ 10_1101-2021_01_06_425584 308 47 cells cell NNS 10_1101-2021_01_06_425584 308 48 involves involve VBZ 10_1101-2021_01_06_425584 308 49 up up IN 10_1101-2021_01_06_425584 308 50 - - HYPH 10_1101-2021_01_06_425584 308 51 regulation regulation NN 10_1101-2021_01_06_425584 308 52 of of IN 10_1101-2021_01_06_425584 308 53 death death NN 10_1101-2021_01_06_425584 308 54 receptors receptor NNS 10_1101-2021_01_06_425584 308 55 . . . 10_1101-2021_01_06_425584 309 1 Cardiovasc Cardiovasc NNP 10_1101-2021_01_06_425584 309 2 Diabetol Diabetol NNP 10_1101-2021_01_06_425584 309 3 2011 2011 CD 10_1101-2021_01_06_425584 309 4 , , , 10_1101-2021_01_06_425584 309 5 10 10 CD 10_1101-2021_01_06_425584 309 6 , , , 10_1101-2021_01_06_425584 309 7 73 73 CD 10_1101-2021_01_06_425584 309 8 . . . 10_1101-2021_01_06_425584 310 1 549 549 CD 10_1101-2021_01_06_425584 310 2 6 6 CD 10_1101-2021_01_06_425584 310 3 . . . 10_1101-2021_01_06_425584 311 1 Dubois Dubois NNP 10_1101-2021_01_06_425584 311 2 , , , 10_1101-2021_01_06_425584 311 3 S. S. NNP 10_1101-2021_01_06_425584 311 4 ; ; : 10_1101-2021_01_06_425584 311 5 Madec Madec NNP 10_1101-2021_01_06_425584 311 6 , , , 10_1101-2021_01_06_425584 311 7 A. a. NN 10_1101-2021_01_06_425584 311 8 M. M. NNP 10_1101-2021_01_06_425584 311 9 ; ; : 10_1101-2021_01_06_425584 311 10 Mesnier Mesnier NNP 10_1101-2021_01_06_425584 311 11 , , , 10_1101-2021_01_06_425584 311 12 A. a. NN 10_1101-2021_01_06_425584 311 13 ; ; : 10_1101-2021_01_06_425584 311 14 Armanet Armanet NNP 10_1101-2021_01_06_425584 311 15 , , , 10_1101-2021_01_06_425584 311 16 M. M. NNP 10_1101-2021_01_06_425584 311 17 ; ; : 10_1101-2021_01_06_425584 311 18 Chikh Chikh NNP 10_1101-2021_01_06_425584 311 19 , , , 10_1101-2021_01_06_425584 311 20 K. K. NNP 10_1101-2021_01_06_425584 311 21 ; ; : 10_1101-2021_01_06_425584 311 22 Berney Berney NNP 10_1101-2021_01_06_425584 311 23 , , , 10_1101-2021_01_06_425584 311 24 T. T. NNP 10_1101-2021_01_06_425584 311 25 ; ; : 10_1101-2021_01_06_425584 311 26 Thivolet Thivolet NNP 10_1101-2021_01_06_425584 311 27 , , , 10_1101-2021_01_06_425584 311 28 C. C. NNP 10_1101-2021_01_06_425584 311 29 , , , 10_1101-2021_01_06_425584 311 30 550 550 CD 10_1101-2021_01_06_425584 311 31 Glucose Glucose NNP 10_1101-2021_01_06_425584 311 32 inhibits inhibit VBZ 10_1101-2021_01_06_425584 311 33 angiogenesis angiogenesis NN 10_1101-2021_01_06_425584 311 34 of of IN 10_1101-2021_01_06_425584 311 35 isolated isolated JJ 10_1101-2021_01_06_425584 311 36 human human JJ 10_1101-2021_01_06_425584 311 37 pancreatic pancreatic JJ 10_1101-2021_01_06_425584 311 38 islets islet NNS 10_1101-2021_01_06_425584 311 39 . . . 10_1101-2021_01_06_425584 312 1 J J NNP 10_1101-2021_01_06_425584 312 2 Mol Mol NNP 10_1101-2021_01_06_425584 312 3 Endocrinol Endocrinol NNP 10_1101-2021_01_06_425584 312 4 2010 2010 CD 10_1101-2021_01_06_425584 312 5 , , , 10_1101-2021_01_06_425584 312 6 45 45 CD 10_1101-2021_01_06_425584 312 7 , , , 10_1101-2021_01_06_425584 312 8 551 551 CD 10_1101-2021_01_06_425584 312 9 ( ( -LRB- 10_1101-2021_01_06_425584 312 10 2 2 CD 10_1101-2021_01_06_425584 312 11 ) ) -RRB- 10_1101-2021_01_06_425584 312 12 , , , 10_1101-2021_01_06_425584 312 13 99 99 CD 10_1101-2021_01_06_425584 312 14 - - SYM 10_1101-2021_01_06_425584 312 15 105 105 CD 10_1101-2021_01_06_425584 312 16 . . . 10_1101-2021_01_06_425584 313 1 552 552 CD 10_1101-2021_01_06_425584 313 2 7 7 CD 10_1101-2021_01_06_425584 313 3 . . . 10_1101-2021_01_06_425584 314 1 Lorenzi Lorenzi NNP 10_1101-2021_01_06_425584 314 2 , , , 10_1101-2021_01_06_425584 314 3 M. M. NNP 10_1101-2021_01_06_425584 314 4 ; ; : 10_1101-2021_01_06_425584 314 5 Montisano Montisano NNP 10_1101-2021_01_06_425584 314 6 , , , 10_1101-2021_01_06_425584 314 7 D. D. NNP 10_1101-2021_01_06_425584 314 8 F. F. NNP 10_1101-2021_01_06_425584 314 9 ; ; : 10_1101-2021_01_06_425584 314 10 Toledo Toledo NNP 10_1101-2021_01_06_425584 314 11 , , , 10_1101-2021_01_06_425584 314 12 S. S. NNP 10_1101-2021_01_06_425584 314 13 ; ; : 10_1101-2021_01_06_425584 314 14 Barrieux Barrieux NNP 10_1101-2021_01_06_425584 314 15 , , , 10_1101-2021_01_06_425584 314 16 A. a. NN 10_1101-2021_01_06_425584 314 17 , , , 10_1101-2021_01_06_425584 314 18 High high JJ 10_1101-2021_01_06_425584 314 19 glucose glucose NN 10_1101-2021_01_06_425584 314 20 induces induce NNS 10_1101-2021_01_06_425584 314 21 DNA dna NN 10_1101-2021_01_06_425584 314 22 553 553 CD 10_1101-2021_01_06_425584 314 23 damage damage NN 10_1101-2021_01_06_425584 314 24 in in IN 10_1101-2021_01_06_425584 314 25 cultured cultured JJ 10_1101-2021_01_06_425584 314 26 human human JJ 10_1101-2021_01_06_425584 314 27 endothelial endothelial JJ 10_1101-2021_01_06_425584 314 28 cells cell NNS 10_1101-2021_01_06_425584 314 29 . . . 10_1101-2021_01_06_425584 315 1 J J NNP 10_1101-2021_01_06_425584 315 2 Clin Clin NNP 10_1101-2021_01_06_425584 315 3 Invest Invest NNP 10_1101-2021_01_06_425584 315 4 1986 1986 CD 10_1101-2021_01_06_425584 315 5 , , , 10_1101-2021_01_06_425584 315 6 77 77 CD 10_1101-2021_01_06_425584 315 7 , , , 10_1101-2021_01_06_425584 315 8 ( ( -LRB- 10_1101-2021_01_06_425584 315 9 1 1 CD 10_1101-2021_01_06_425584 315 10 ) ) -RRB- 10_1101-2021_01_06_425584 315 11 , , , 10_1101-2021_01_06_425584 315 12 322 322 CD 10_1101-2021_01_06_425584 315 13 - - SYM 10_1101-2021_01_06_425584 315 14 5 5 CD 10_1101-2021_01_06_425584 315 15 . . . 10_1101-2021_01_06_425584 316 1 554 554 CD 10_1101-2021_01_06_425584 316 2 8 8 CD 10_1101-2021_01_06_425584 316 3 . . . 10_1101-2021_01_06_425584 317 1 Patel Patel NNP 10_1101-2021_01_06_425584 317 2 , , , 10_1101-2021_01_06_425584 317 3 H. H. NNP 10_1101-2021_01_06_425584 317 4 ; ; : 10_1101-2021_01_06_425584 317 5 Chen Chen NNP 10_1101-2021_01_06_425584 317 6 , , , 10_1101-2021_01_06_425584 317 7 J. J. NNP 10_1101-2021_01_06_425584 317 8 ; ; : 10_1101-2021_01_06_425584 317 9 Das Das NNP 10_1101-2021_01_06_425584 317 10 , , , 10_1101-2021_01_06_425584 317 11 K. K. NNP 10_1101-2021_01_06_425584 317 12 C. C. NNP 10_1101-2021_01_06_425584 317 13 ; ; : 10_1101-2021_01_06_425584 317 14 Kavdia Kavdia NNP 10_1101-2021_01_06_425584 317 15 , , , 10_1101-2021_01_06_425584 317 16 M. M. NNP 10_1101-2021_01_06_425584 317 17 , , , 10_1101-2021_01_06_425584 317 18 Hyperglycemia Hyperglycemia NNP 10_1101-2021_01_06_425584 317 19 induces induce VBZ 10_1101-2021_01_06_425584 317 20 differential differential VBP 10_1101-2021_01_06_425584 317 21 change change NN 10_1101-2021_01_06_425584 317 22 in in IN 10_1101-2021_01_06_425584 317 23 555 555 CD 10_1101-2021_01_06_425584 317 24 oxidative oxidative JJ 10_1101-2021_01_06_425584 317 25 stress stress NN 10_1101-2021_01_06_425584 317 26 at at IN 10_1101-2021_01_06_425584 317 27 gene gene NN 10_1101-2021_01_06_425584 317 28 expression expression NN 10_1101-2021_01_06_425584 317 29 and and CC 10_1101-2021_01_06_425584 317 30 functional functional JJ 10_1101-2021_01_06_425584 317 31 levels level NNS 10_1101-2021_01_06_425584 317 32 in in IN 10_1101-2021_01_06_425584 317 33 HUVEC HUVEC NNP 10_1101-2021_01_06_425584 317 34 and and CC 10_1101-2021_01_06_425584 317 35 HMVEC HMVEC NNP 10_1101-2021_01_06_425584 317 36 . . . 10_1101-2021_01_06_425584 318 1 Cardiovasc Cardiovasc NNP 10_1101-2021_01_06_425584 318 2 556 556 CD 10_1101-2021_01_06_425584 318 3 Diabetol Diabetol NNP 10_1101-2021_01_06_425584 318 4 2013 2013 CD 10_1101-2021_01_06_425584 318 5 , , , 10_1101-2021_01_06_425584 318 6 12 12 CD 10_1101-2021_01_06_425584 318 7 , , , 10_1101-2021_01_06_425584 318 8 142 142 CD 10_1101-2021_01_06_425584 318 9 . . . 10_1101-2021_01_06_425584 319 1 557 557 CD 10_1101-2021_01_06_425584 319 2 9 9 CD 10_1101-2021_01_06_425584 319 3 . . . 10_1101-2021_01_06_425584 320 1 Pala Pala NNP 10_1101-2021_01_06_425584 320 2 , , , 10_1101-2021_01_06_425584 320 3 L. L. NNP 10_1101-2021_01_06_425584 320 4 ; ; : 10_1101-2021_01_06_425584 320 5 Pezzatini Pezzatini NNP 10_1101-2021_01_06_425584 320 6 , , , 10_1101-2021_01_06_425584 320 7 A. a. NN 10_1101-2021_01_06_425584 320 8 ; ; : 10_1101-2021_01_06_425584 320 9 Dicembrini Dicembrini NNP 10_1101-2021_01_06_425584 320 10 , , , 10_1101-2021_01_06_425584 320 11 I. i. NN 10_1101-2021_01_06_425584 320 12 ; ; : 10_1101-2021_01_06_425584 320 13 Ciani Ciani NNP 10_1101-2021_01_06_425584 320 14 , , , 10_1101-2021_01_06_425584 320 15 S. S. NNP 10_1101-2021_01_06_425584 320 16 ; ; : 10_1101-2021_01_06_425584 320 17 Gelmini Gelmini NNP 10_1101-2021_01_06_425584 320 18 , , , 10_1101-2021_01_06_425584 320 19 S. S. NNP 10_1101-2021_01_06_425584 320 20 ; ; : 10_1101-2021_01_06_425584 320 21 Vannelli Vannelli NNP 10_1101-2021_01_06_425584 320 22 , , , 10_1101-2021_01_06_425584 320 23 B. B. NNP 10_1101-2021_01_06_425584 320 24 G. G. NNP 10_1101-2021_01_06_425584 320 25 ; ; : 10_1101-2021_01_06_425584 320 26 Cresci Cresci NNP 10_1101-2021_01_06_425584 320 27 , , , 10_1101-2021_01_06_425584 320 28 B. B. NNP 10_1101-2021_01_06_425584 320 29 ; ; : 10_1101-2021_01_06_425584 320 30 558 558 CD 10_1101-2021_01_06_425584 320 31 Mannucci Mannucci NNP 10_1101-2021_01_06_425584 320 32 , , , 10_1101-2021_01_06_425584 320 33 E. E. NNP 10_1101-2021_01_06_425584 320 34 ; ; : 10_1101-2021_01_06_425584 320 35 Rotella Rotella NNP 10_1101-2021_01_06_425584 320 36 , , , 10_1101-2021_01_06_425584 320 37 C. C. NNP 10_1101-2021_01_06_425584 320 38 M. M. NNP 10_1101-2021_01_06_425584 320 39 , , , 10_1101-2021_01_06_425584 320 40 Different different JJ 10_1101-2021_01_06_425584 320 41 modulation modulation NN 10_1101-2021_01_06_425584 320 42 of of IN 10_1101-2021_01_06_425584 320 43 dipeptidyl dipeptidyl JJ 10_1101-2021_01_06_425584 320 44 peptidase-4 peptidase-4 NNP 10_1101-2021_01_06_425584 320 45 activity activity NN 10_1101-2021_01_06_425584 320 46 between between IN 10_1101-2021_01_06_425584 320 47 559 559 CD 10_1101-2021_01_06_425584 320 48 microvascular microvascular JJ 10_1101-2021_01_06_425584 320 49 and and CC 10_1101-2021_01_06_425584 320 50 macrovascular macrovascular JJ 10_1101-2021_01_06_425584 320 51 human human JJ 10_1101-2021_01_06_425584 320 52 endothelial endothelial JJ 10_1101-2021_01_06_425584 320 53 cells cell NNS 10_1101-2021_01_06_425584 320 54 . . . 10_1101-2021_01_06_425584 321 1 Acta Acta NNP 10_1101-2021_01_06_425584 321 2 Diabetol Diabetol NNP 10_1101-2021_01_06_425584 321 3 2012 2012 CD 10_1101-2021_01_06_425584 321 4 , , , 10_1101-2021_01_06_425584 321 5 49 49 CD 10_1101-2021_01_06_425584 321 6 Suppl suppl NN 10_1101-2021_01_06_425584 321 7 1 1 CD 10_1101-2021_01_06_425584 321 8 , , , 10_1101-2021_01_06_425584 321 9 560 560 CD 10_1101-2021_01_06_425584 321 10 S59 S59 NNP 10_1101-2021_01_06_425584 321 11 - - HYPH 10_1101-2021_01_06_425584 321 12 63 63 CD 10_1101-2021_01_06_425584 321 13 . . . 10_1101-2021_01_06_425584 322 1 561 561 CD 10_1101-2021_01_06_425584 322 2 10 10 CD 10_1101-2021_01_06_425584 322 3 . . . 10_1101-2021_01_06_425584 323 1 Esposito Esposito NNP 10_1101-2021_01_06_425584 323 2 , , , 10_1101-2021_01_06_425584 323 3 C. C. NNP 10_1101-2021_01_06_425584 323 4 ; ; : 10_1101-2021_01_06_425584 323 5 Fasoli Fasoli NNP 10_1101-2021_01_06_425584 323 6 , , , 10_1101-2021_01_06_425584 323 7 G. G. NNP 10_1101-2021_01_06_425584 323 8 ; ; : 10_1101-2021_01_06_425584 323 9 Plati Plati NNP 10_1101-2021_01_06_425584 323 10 , , , 10_1101-2021_01_06_425584 323 11 A. A. NNP 10_1101-2021_01_06_425584 323 12 R. R. NNP 10_1101-2021_01_06_425584 323 13 ; ; : 10_1101-2021_01_06_425584 323 14 Bellotti Bellotti NNP 10_1101-2021_01_06_425584 323 15 , , , 10_1101-2021_01_06_425584 323 16 N. N. NNP 10_1101-2021_01_06_425584 323 17 ; ; : 10_1101-2021_01_06_425584 323 18 Conte Conte NNP 10_1101-2021_01_06_425584 323 19 , , , 10_1101-2021_01_06_425584 323 20 M. M. NNP 10_1101-2021_01_06_425584 323 21 M. M. NNP 10_1101-2021_01_06_425584 323 22 ; ; : 10_1101-2021_01_06_425584 323 23 Cornacchia Cornacchia NNP 10_1101-2021_01_06_425584 323 24 , , , 10_1101-2021_01_06_425584 323 25 F. F. NNP 10_1101-2021_01_06_425584 323 26 ; ; : 10_1101-2021_01_06_425584 323 27 Foschi Foschi NNP 10_1101-2021_01_06_425584 323 28 , , , 10_1101-2021_01_06_425584 323 29 A. a. NN 10_1101-2021_01_06_425584 323 30 ; ; : 10_1101-2021_01_06_425584 323 31 562 562 CD 10_1101-2021_01_06_425584 323 32 Mazzullo Mazzullo NNP 10_1101-2021_01_06_425584 323 33 , , , 10_1101-2021_01_06_425584 323 34 T. T. NNP 10_1101-2021_01_06_425584 323 35 ; ; : 10_1101-2021_01_06_425584 323 36 Semeraro Semeraro NNP 10_1101-2021_01_06_425584 323 37 , , , 10_1101-2021_01_06_425584 323 38 L. L. NNP 10_1101-2021_01_06_425584 323 39 ; ; : 10_1101-2021_01_06_425584 323 40 Dal Dal NNP 10_1101-2021_01_06_425584 323 41 Canton Canton NNP 10_1101-2021_01_06_425584 323 42 , , , 10_1101-2021_01_06_425584 323 43 A. a. NN 10_1101-2021_01_06_425584 323 44 , , , 10_1101-2021_01_06_425584 323 45 Long long JJ 10_1101-2021_01_06_425584 323 46 - - HYPH 10_1101-2021_01_06_425584 323 47 term term NN 10_1101-2021_01_06_425584 323 48 exposure exposure NN 10_1101-2021_01_06_425584 323 49 to to IN 10_1101-2021_01_06_425584 323 50 high high JJ 10_1101-2021_01_06_425584 323 51 glucose glucose VB 10_1101-2021_01_06_425584 323 52 up up RP 10_1101-2021_01_06_425584 323 53 - - HYPH 10_1101-2021_01_06_425584 323 54 regulates regulate VBZ 10_1101-2021_01_06_425584 323 55 563 563 CD 10_1101-2021_01_06_425584 323 56 VCAM VCAM NNS 10_1101-2021_01_06_425584 323 57 - - HYPH 10_1101-2021_01_06_425584 323 58 induced induce VBN 10_1101-2021_01_06_425584 323 59 endothelial endothelial JJ 10_1101-2021_01_06_425584 323 60 cell cell NN 10_1101-2021_01_06_425584 323 61 adhesiveness adhesiveness NN 10_1101-2021_01_06_425584 323 62 to to IN 10_1101-2021_01_06_425584 323 63 PBMC PBMC NNP 10_1101-2021_01_06_425584 323 64 . . . 10_1101-2021_01_06_425584 324 1 Kidney Kidney NNP 10_1101-2021_01_06_425584 324 2 Int Int NNP 10_1101-2021_01_06_425584 324 3 2001 2001 CD 10_1101-2021_01_06_425584 324 4 , , , 10_1101-2021_01_06_425584 324 5 59 59 CD 10_1101-2021_01_06_425584 324 6 , , , 10_1101-2021_01_06_425584 324 7 ( ( -LRB- 10_1101-2021_01_06_425584 324 8 5 5 CD 10_1101-2021_01_06_425584 324 9 ) ) -RRB- 10_1101-2021_01_06_425584 324 10 , , , 10_1101-2021_01_06_425584 324 11 1842 1842 CD 10_1101-2021_01_06_425584 324 12 - - SYM 10_1101-2021_01_06_425584 324 13 9 9 CD 10_1101-2021_01_06_425584 324 14 . . . 10_1101-2021_01_06_425584 325 1 564 564 CD 10_1101-2021_01_06_425584 325 2 11 11 CD 10_1101-2021_01_06_425584 325 3 . . . 10_1101-2021_01_06_425584 326 1 Baumgartner Baumgartner NNP 10_1101-2021_01_06_425584 326 2 - - HYPH 10_1101-2021_01_06_425584 326 3 Parzer Parzer NNP 10_1101-2021_01_06_425584 326 4 , , , 10_1101-2021_01_06_425584 326 5 S. S. NNP 10_1101-2021_01_06_425584 326 6 M. M. NNP 10_1101-2021_01_06_425584 326 7 ; ; : 10_1101-2021_01_06_425584 326 8 Wagner Wagner NNP 10_1101-2021_01_06_425584 326 9 , , , 10_1101-2021_01_06_425584 326 10 L. L. NNP 10_1101-2021_01_06_425584 326 11 ; ; : 10_1101-2021_01_06_425584 326 12 Pettermann Pettermann NNP 10_1101-2021_01_06_425584 326 13 , , , 10_1101-2021_01_06_425584 326 14 M. M. NNP 10_1101-2021_01_06_425584 326 15 ; ; : 10_1101-2021_01_06_425584 326 16 Grillari Grillari NNP 10_1101-2021_01_06_425584 326 17 , , , 10_1101-2021_01_06_425584 326 18 J. J. NNP 10_1101-2021_01_06_425584 326 19 ; ; : 10_1101-2021_01_06_425584 326 20 Gessl Gessl NNP 10_1101-2021_01_06_425584 326 21 , , , 10_1101-2021_01_06_425584 326 22 A. a. NN 10_1101-2021_01_06_425584 326 23 ; ; : 10_1101-2021_01_06_425584 326 24 565 565 CD 10_1101-2021_01_06_425584 326 25 Waldhausl Waldhausl NNP 10_1101-2021_01_06_425584 326 26 , , , 10_1101-2021_01_06_425584 326 27 W. W. NNP 10_1101-2021_01_06_425584 326 28 , , , 10_1101-2021_01_06_425584 326 29 High High NNP 10_1101-2021_01_06_425584 326 30 - - HYPH 10_1101-2021_01_06_425584 326 31 glucose glucose NNP 10_1101-2021_01_06_425584 326 32 -- -- : 10_1101-2021_01_06_425584 326 33 triggered trigger VBD 10_1101-2021_01_06_425584 326 34 apoptosis apoptosis NN 10_1101-2021_01_06_425584 326 35 in in IN 10_1101-2021_01_06_425584 326 36 cultured cultured JJ 10_1101-2021_01_06_425584 326 37 endothelial endothelial JJ 10_1101-2021_01_06_425584 326 38 cells cell NNS 10_1101-2021_01_06_425584 326 39 . . . 10_1101-2021_01_06_425584 327 1 Diabetes diabetes NN 10_1101-2021_01_06_425584 327 2 1995 1995 CD 10_1101-2021_01_06_425584 327 3 , , , 10_1101-2021_01_06_425584 327 4 566 566 CD 10_1101-2021_01_06_425584 327 5 44 44 CD 10_1101-2021_01_06_425584 327 6 , , , 10_1101-2021_01_06_425584 327 7 ( ( -LRB- 10_1101-2021_01_06_425584 327 8 11 11 CD 10_1101-2021_01_06_425584 327 9 ) ) -RRB- 10_1101-2021_01_06_425584 327 10 , , , 10_1101-2021_01_06_425584 327 11 1323 1323 CD 10_1101-2021_01_06_425584 327 12 - - SYM 10_1101-2021_01_06_425584 327 13 7 7 CD 10_1101-2021_01_06_425584 327 14 . . . 10_1101-2021_01_06_425584 328 1 567 567 CD 10_1101-2021_01_06_425584 328 2 12 12 CD 10_1101-2021_01_06_425584 328 3 . . . 10_1101-2021_01_06_425584 329 1 Ramirez Ramirez NNP 10_1101-2021_01_06_425584 329 2 - - HYPH 10_1101-2021_01_06_425584 329 3 Sanchez Sanchez NNP 10_1101-2021_01_06_425584 329 4 , , , 10_1101-2021_01_06_425584 329 5 I. I. NNP 10_1101-2021_01_06_425584 329 6 ; ; : 10_1101-2021_01_06_425584 329 7 Rodriguez Rodriguez NNP 10_1101-2021_01_06_425584 329 8 , , , 10_1101-2021_01_06_425584 329 9 A. a. NN 10_1101-2021_01_06_425584 329 10 ; ; : 10_1101-2021_01_06_425584 329 11 Moreno Moreno NNP 10_1101-2021_01_06_425584 329 12 - - HYPH 10_1101-2021_01_06_425584 329 13 Ulloa Ulloa NNP 10_1101-2021_01_06_425584 329 14 , , , 10_1101-2021_01_06_425584 329 15 A. a. NN 10_1101-2021_01_06_425584 329 16 ; ; : 10_1101-2021_01_06_425584 329 17 Ceballos Ceballos NNP 10_1101-2021_01_06_425584 329 18 , , , 10_1101-2021_01_06_425584 329 19 G. G. NNP 10_1101-2021_01_06_425584 329 20 ; ; : 10_1101-2021_01_06_425584 329 21 Villarreal Villarreal NNP 10_1101-2021_01_06_425584 329 22 , , , 10_1101-2021_01_06_425584 329 23 F. F. NNP 10_1101-2021_01_06_425584 329 24 , , , 10_1101-2021_01_06_425584 329 25 ( ( -LRB- 10_1101-2021_01_06_425584 329 26 -)-568 -)-568 NNP 10_1101-2021_01_06_425584 329 27 Epicatechin epicatechin NN 10_1101-2021_01_06_425584 329 28 - - HYPH 10_1101-2021_01_06_425584 329 29 induced induce VBN 10_1101-2021_01_06_425584 329 30 recovery recovery NN 10_1101-2021_01_06_425584 329 31 of of IN 10_1101-2021_01_06_425584 329 32 mitochondria mitochondria NNP 10_1101-2021_01_06_425584 329 33 from from IN 10_1101-2021_01_06_425584 329 34 simulated simulated JJ 10_1101-2021_01_06_425584 329 35 diabetes diabete NNS 10_1101-2021_01_06_425584 329 36 : : : 10_1101-2021_01_06_425584 329 37 Potential potential JJ 10_1101-2021_01_06_425584 329 38 role role NN 10_1101-2021_01_06_425584 329 39 of of IN 10_1101-2021_01_06_425584 329 40 569 569 CD 10_1101-2021_01_06_425584 329 41 endothelial endothelial JJ 10_1101-2021_01_06_425584 329 42 nitric nitric NN 10_1101-2021_01_06_425584 329 43 oxide oxide NN 10_1101-2021_01_06_425584 329 44 synthase synthase NN 10_1101-2021_01_06_425584 329 45 . . . 10_1101-2021_01_06_425584 330 1 Diab Diab NNP 10_1101-2021_01_06_425584 330 2 Vasc Vasc NNP 10_1101-2021_01_06_425584 330 3 Dis Dis NNP 10_1101-2021_01_06_425584 330 4 Res Res NNP 10_1101-2021_01_06_425584 330 5 2016 2016 CD 10_1101-2021_01_06_425584 330 6 , , , 10_1101-2021_01_06_425584 330 7 13 13 CD 10_1101-2021_01_06_425584 330 8 , , , 10_1101-2021_01_06_425584 330 9 ( ( -LRB- 10_1101-2021_01_06_425584 330 10 3 3 CD 10_1101-2021_01_06_425584 330 11 ) ) -RRB- 10_1101-2021_01_06_425584 330 12 , , , 10_1101-2021_01_06_425584 330 13 201 201 CD 10_1101-2021_01_06_425584 330 14 - - SYM 10_1101-2021_01_06_425584 330 15 10 10 CD 10_1101-2021_01_06_425584 330 16 . . . 10_1101-2021_01_06_425584 331 1 570 570 CD 10_1101-2021_01_06_425584 331 2 13 13 CD 10_1101-2021_01_06_425584 331 3 . . . 10_1101-2021_01_06_425584 332 1 Liu Liu NNP 10_1101-2021_01_06_425584 332 2 , , , 10_1101-2021_01_06_425584 332 3 T. t. NN 10_1101-2021_01_06_425584 332 4 ; ; : 10_1101-2021_01_06_425584 332 5 Gong Gong NNP 10_1101-2021_01_06_425584 332 6 , , , 10_1101-2021_01_06_425584 332 7 J. J. NNP 10_1101-2021_01_06_425584 332 8 ; ; : 10_1101-2021_01_06_425584 332 9 Chen Chen NNP 10_1101-2021_01_06_425584 332 10 , , , 10_1101-2021_01_06_425584 332 11 Y. Y. NNP 10_1101-2021_01_06_425584 332 12 ; ; : 10_1101-2021_01_06_425584 332 13 Jiang Jiang NNP 10_1101-2021_01_06_425584 332 14 , , , 10_1101-2021_01_06_425584 332 15 S. S. NNP 10_1101-2021_01_06_425584 332 16 , , , 10_1101-2021_01_06_425584 332 17 Periodic Periodic NNP 10_1101-2021_01_06_425584 332 18 vs vs IN 10_1101-2021_01_06_425584 332 19 constant constant JJ 10_1101-2021_01_06_425584 332 20 high high JJ 10_1101-2021_01_06_425584 332 21 glucose glucose NN 10_1101-2021_01_06_425584 332 22 in in IN 10_1101-2021_01_06_425584 332 23 inducing induce VBG 10_1101-2021_01_06_425584 332 24 pro-571 pro-571 VB 10_1101-2021_01_06_425584 332 25 inflammatory inflammatory JJ 10_1101-2021_01_06_425584 332 26 cytokine cytokine JJ 10_1101-2021_01_06_425584 332 27 expression expression NN 10_1101-2021_01_06_425584 332 28 in in IN 10_1101-2021_01_06_425584 332 29 human human JJ 10_1101-2021_01_06_425584 332 30 coronary coronary JJ 10_1101-2021_01_06_425584 332 31 artery artery NN 10_1101-2021_01_06_425584 332 32 endothelial endothelial JJ 10_1101-2021_01_06_425584 332 33 cells cell NNS 10_1101-2021_01_06_425584 332 34 . . . 10_1101-2021_01_06_425584 333 1 Inflamm Inflamm NNP 10_1101-2021_01_06_425584 333 2 Res Res NNP 10_1101-2021_01_06_425584 333 3 2013 2013 CD 10_1101-2021_01_06_425584 333 4 , , , 10_1101-2021_01_06_425584 333 5 572 572 CD 10_1101-2021_01_06_425584 333 6 62 62 CD 10_1101-2021_01_06_425584 333 7 , , , 10_1101-2021_01_06_425584 333 8 ( ( -LRB- 10_1101-2021_01_06_425584 333 9 7 7 CD 10_1101-2021_01_06_425584 333 10 ) ) -RRB- 10_1101-2021_01_06_425584 333 11 , , , 10_1101-2021_01_06_425584 333 12 697 697 CD 10_1101-2021_01_06_425584 333 13 - - SYM 10_1101-2021_01_06_425584 333 14 701 701 CD 10_1101-2021_01_06_425584 333 15 . . . 10_1101-2021_01_06_425584 334 1 573 573 CD 10_1101-2021_01_06_425584 334 2 14 14 CD 10_1101-2021_01_06_425584 334 3 . . . 10_1101-2021_01_06_425584 335 1 Liu Liu NNP 10_1101-2021_01_06_425584 335 2 , , , 10_1101-2021_01_06_425584 335 3 T. T. NNP 10_1101-2021_01_06_425584 335 4 S. S. NNP 10_1101-2021_01_06_425584 335 5 ; ; : 10_1101-2021_01_06_425584 335 6 Pei Pei NNP 10_1101-2021_01_06_425584 335 7 , , , 10_1101-2021_01_06_425584 335 8 Y. Y. NNP 10_1101-2021_01_06_425584 335 9 H. H. NNP 10_1101-2021_01_06_425584 335 10 ; ; : 10_1101-2021_01_06_425584 335 11 Peng Peng NNP 10_1101-2021_01_06_425584 335 12 , , , 10_1101-2021_01_06_425584 335 13 Y. Y. NNP 10_1101-2021_01_06_425584 335 14 P. P. NNP 10_1101-2021_01_06_425584 335 15 ; ; : 10_1101-2021_01_06_425584 335 16 Chen Chen NNP 10_1101-2021_01_06_425584 335 17 , , , 10_1101-2021_01_06_425584 335 18 J. J. NNP 10_1101-2021_01_06_425584 335 19 ; ; : 10_1101-2021_01_06_425584 335 20 Jiang Jiang NNP 10_1101-2021_01_06_425584 335 21 , , , 10_1101-2021_01_06_425584 335 22 S. S. NNP 10_1101-2021_01_06_425584 335 23 S. S. NNP 10_1101-2021_01_06_425584 335 24 ; ; : 10_1101-2021_01_06_425584 335 25 Gong Gong NNP 10_1101-2021_01_06_425584 335 26 , , , 10_1101-2021_01_06_425584 335 27 J. J. NNP 10_1101-2021_01_06_425584 336 1 B. B. NNP 10_1101-2021_01_06_425584 336 2 , , , 10_1101-2021_01_06_425584 336 3 Oscillating oscillate VBG 10_1101-2021_01_06_425584 336 4 high high JJ 10_1101-2021_01_06_425584 336 5 574 574 CD 10_1101-2021_01_06_425584 336 6 glucose glucose NN 10_1101-2021_01_06_425584 336 7 enhances enhance VBZ 10_1101-2021_01_06_425584 336 8 oxidative oxidative JJ 10_1101-2021_01_06_425584 336 9 stress stress NN 10_1101-2021_01_06_425584 336 10 and and CC 10_1101-2021_01_06_425584 336 11 apoptosis apoptosis NN 10_1101-2021_01_06_425584 336 12 in in IN 10_1101-2021_01_06_425584 336 13 human human JJ 10_1101-2021_01_06_425584 336 14 coronary coronary JJ 10_1101-2021_01_06_425584 336 15 artery artery NN 10_1101-2021_01_06_425584 336 16 endothelial endothelial JJ 10_1101-2021_01_06_425584 336 17 cells cell NNS 10_1101-2021_01_06_425584 336 18 . . . 10_1101-2021_01_06_425584 337 1 J J NNP 10_1101-2021_01_06_425584 337 2 575 575 CD 10_1101-2021_01_06_425584 337 3 Endocrinol Endocrinol NNP 10_1101-2021_01_06_425584 337 4 Invest Invest NNP 10_1101-2021_01_06_425584 337 5 2014 2014 CD 10_1101-2021_01_06_425584 337 6 , , , 10_1101-2021_01_06_425584 337 7 37 37 CD 10_1101-2021_01_06_425584 337 8 , , , 10_1101-2021_01_06_425584 337 9 ( ( -LRB- 10_1101-2021_01_06_425584 337 10 7 7 CD 10_1101-2021_01_06_425584 337 11 ) ) -RRB- 10_1101-2021_01_06_425584 337 12 , , , 10_1101-2021_01_06_425584 337 13 645 645 CD 10_1101-2021_01_06_425584 337 14 - - SYM 10_1101-2021_01_06_425584 337 15 51 51 CD 10_1101-2021_01_06_425584 337 16 . . . 10_1101-2021_01_06_425584 338 1 576 576 CD 10_1101-2021_01_06_425584 338 2 15 15 CD 10_1101-2021_01_06_425584 338 3 . . . 10_1101-2021_01_06_425584 339 1 Hilda Hilda NNP 10_1101-2021_01_06_425584 339 2 Carolina Carolina NNP 10_1101-2021_01_06_425584 339 3 Delgado Delgado NNP 10_1101-2021_01_06_425584 339 4 De De NNP 10_1101-2021_01_06_425584 339 5 la la NNP 10_1101-2021_01_06_425584 339 6 Herrán Herrán NNP 10_1101-2021_01_06_425584 339 7 , , , 10_1101-2021_01_06_425584 339 8 L. L. NNP 10_1101-2021_01_06_425584 339 9 D.-M. D.-M. NNP 10_1101-2021_01_06_425584 339 10 , , , 10_1101-2021_01_06_425584 339 11 Carolina Carolina NNP 10_1101-2021_01_06_425584 339 12 Álvarez Álvarez NNP 10_1101-2021_01_06_425584 339 13 - - HYPH 10_1101-2021_01_06_425584 339 14 Delgado Delgado NNP 10_1101-2021_01_06_425584 339 15 , , , 10_1101-2021_01_06_425584 339 16 Francisco Francisco NNP 10_1101-2021_01_06_425584 339 17 577 577 CD 10_1101-2021_01_06_425584 339 18 Villarreal villarreal NN 10_1101-2021_01_06_425584 339 19 , , , 10_1101-2021_01_06_425584 339 20 Aldo Aldo NNP 10_1101-2021_01_06_425584 339 21 Moreno Moreno NNP 10_1101-2021_01_06_425584 339 22 - - HYPH 10_1101-2021_01_06_425584 339 23 Ulloa Ulloa NNP 10_1101-2021_01_06_425584 339 24 , , , 10_1101-2021_01_06_425584 339 25 Formation formation NN 10_1101-2021_01_06_425584 339 26 of of IN 10_1101-2021_01_06_425584 339 27 multinucleated multinucleate VBN 10_1101-2021_01_06_425584 339 28 variant variant JJ 10_1101-2021_01_06_425584 339 29 endothelial endothelial JJ 10_1101-2021_01_06_425584 339 30 cells cell NNS 10_1101-2021_01_06_425584 339 31 with with IN 10_1101-2021_01_06_425584 339 32 altered altered JJ 10_1101-2021_01_06_425584 339 33 578 578 CD 10_1101-2021_01_06_425584 339 34 mitochondrial mitochondrial NN 10_1101-2021_01_06_425584 339 35 function function NN 10_1101-2021_01_06_425584 339 36 in in IN 10_1101-2021_01_06_425584 339 37 cultured cultured JJ 10_1101-2021_01_06_425584 339 38 coronary coronary JJ 10_1101-2021_01_06_425584 339 39 endothelium endothelium NN 10_1101-2021_01_06_425584 339 40 under under IN 10_1101-2021_01_06_425584 339 41 simulated simulate VBN 10_1101-2021_01_06_425584 339 42 diabetes diabete NNS 10_1101-2021_01_06_425584 339 43 . . . 10_1101-2021_01_06_425584 340 1 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 340 2 579 579 CD 10_1101-2021_01_06_425584 340 3 2019 2019 CD 10_1101-2021_01_06_425584 340 4 . . . 10_1101-2021_01_06_425584 341 1 580 580 CD 10_1101-2021_01_06_425584 341 2 .CC .CC NFP 10_1101-2021_01_06_425584 341 3 - - HYPH 10_1101-2021_01_06_425584 341 4 BY by IN 10_1101-2021_01_06_425584 341 5 - - HYPH 10_1101-2021_01_06_425584 341 6 NC NC NNP 10_1101-2021_01_06_425584 341 7 - - HYPH 10_1101-2021_01_06_425584 341 8 ND ND NNP 10_1101-2021_01_06_425584 341 9 4.0 4.0 CD 10_1101-2021_01_06_425584 341 10 International International NNP 10_1101-2021_01_06_425584 341 11 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 341 12 under under IN 10_1101-2021_01_06_425584 341 13 a a DT 10_1101-2021_01_06_425584 341 14 ( ( -LRB- 10_1101-2021_01_06_425584 341 15 which which WDT 10_1101-2021_01_06_425584 341 16 was be VBD 10_1101-2021_01_06_425584 341 17 not not RB 10_1101-2021_01_06_425584 341 18 certified certify VBN 10_1101-2021_01_06_425584 341 19 by by IN 10_1101-2021_01_06_425584 341 20 peer peer NN 10_1101-2021_01_06_425584 341 21 review review NN 10_1101-2021_01_06_425584 341 22 ) ) -RRB- 10_1101-2021_01_06_425584 341 23 is be VBZ 10_1101-2021_01_06_425584 341 24 the the DT 10_1101-2021_01_06_425584 341 25 author author NN 10_1101-2021_01_06_425584 341 26 / / SYM 10_1101-2021_01_06_425584 341 27 funder funder NN 10_1101-2021_01_06_425584 341 28 , , , 10_1101-2021_01_06_425584 341 29 who who WP 10_1101-2021_01_06_425584 341 30 has have VBZ 10_1101-2021_01_06_425584 341 31 granted grant VBN 10_1101-2021_01_06_425584 341 32 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 341 33 a a DT 10_1101-2021_01_06_425584 341 34 license license NN 10_1101-2021_01_06_425584 341 35 to to TO 10_1101-2021_01_06_425584 341 36 display display VB 10_1101-2021_01_06_425584 341 37 the the DT 10_1101-2021_01_06_425584 341 38 preprint preprint NN 10_1101-2021_01_06_425584 341 39 in in IN 10_1101-2021_01_06_425584 341 40 perpetuity perpetuity NN 10_1101-2021_01_06_425584 341 41 . . . 10_1101-2021_01_06_425584 342 1 It -PRON- PRP 10_1101-2021_01_06_425584 342 2 is be VBZ 10_1101-2021_01_06_425584 342 3 made make VBN 10_1101-2021_01_06_425584 342 4 The the DT 10_1101-2021_01_06_425584 342 5 copyright copyright NN 10_1101-2021_01_06_425584 342 6 holder holder NN 10_1101-2021_01_06_425584 342 7 for for IN 10_1101-2021_01_06_425584 342 8 this this DT 10_1101-2021_01_06_425584 342 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 342 10 version version NN 10_1101-2021_01_06_425584 342 11 posted post VBD 10_1101-2021_01_06_425584 342 12 January January NNP 10_1101-2021_01_06_425584 342 13 8 8 CD 10_1101-2021_01_06_425584 342 14 , , , 10_1101-2021_01_06_425584 342 15 2021 2021 CD 10_1101-2021_01_06_425584 342 16 . . . 10_1101-2021_01_06_425584 342 17 ; ; : 10_1101-2021_01_06_425584 342 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 342 19 : : : 10_1101-2021_01_06_425584 342 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 342 21 preprint preprint NN 10_1101-2021_01_06_425584 342 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 342 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 342 24 22 22 CD 10_1101-2021_01_06_425584 342 25 16 16 CD 10_1101-2021_01_06_425584 342 26 . . . 10_1101-2021_01_06_425584 343 1 Li Li NNP 10_1101-2021_01_06_425584 343 2 , , , 10_1101-2021_01_06_425584 343 3 X. X. NNP 10_1101-2021_01_06_425584 343 4 X. X. NNP 10_1101-2021_01_06_425584 343 5 ; ; : 10_1101-2021_01_06_425584 343 6 Liu Liu NNP 10_1101-2021_01_06_425584 343 7 , , , 10_1101-2021_01_06_425584 343 8 Y. Y. NNP 10_1101-2021_01_06_425584 343 9 M. M. NNP 10_1101-2021_01_06_425584 343 10 ; ; : 10_1101-2021_01_06_425584 343 11 Li Li NNP 10_1101-2021_01_06_425584 343 12 , , , 10_1101-2021_01_06_425584 343 13 Y. Y. NNP 10_1101-2021_01_06_425584 343 14 J. J. NNP 10_1101-2021_01_06_425584 343 15 ; ; : 10_1101-2021_01_06_425584 343 16 Xie Xie NNP 10_1101-2021_01_06_425584 343 17 , , , 10_1101-2021_01_06_425584 343 18 N. N. NNP 10_1101-2021_01_06_425584 343 19 ; ; : 10_1101-2021_01_06_425584 343 20 Yan Yan NNP 10_1101-2021_01_06_425584 343 21 , , , 10_1101-2021_01_06_425584 343 22 Y. Y. NNP 10_1101-2021_01_06_425584 343 23 F. F. NNP 10_1101-2021_01_06_425584 343 24 ; ; : 10_1101-2021_01_06_425584 343 25 Chi Chi NNP 10_1101-2021_01_06_425584 343 26 , , , 10_1101-2021_01_06_425584 343 27 Y. Y. NNP 10_1101-2021_01_06_425584 343 28 L. L. NNP 10_1101-2021_01_06_425584 343 29 ; ; : 10_1101-2021_01_06_425584 343 30 Zhou Zhou NNP 10_1101-2021_01_06_425584 343 31 , , , 10_1101-2021_01_06_425584 343 32 L. L. NNP 10_1101-2021_01_06_425584 343 33 ; ; : 10_1101-2021_01_06_425584 343 34 Xie Xie NNP 10_1101-2021_01_06_425584 343 35 , , , 10_1101-2021_01_06_425584 343 36 S. S. NNP 10_1101-2021_01_06_425584 343 37 Y. Y. NNP 10_1101-2021_01_06_425584 343 38 ; ; : 10_1101-2021_01_06_425584 343 39 Wang Wang NNP 10_1101-2021_01_06_425584 343 40 , , , 10_1101-2021_01_06_425584 343 41 P. P. NNP 10_1101-2021_01_06_425584 343 42 581 581 CD 10_1101-2021_01_06_425584 343 43 Y. Y. NNP 10_1101-2021_01_06_425584 343 44 , , , 10_1101-2021_01_06_425584 343 45 High High NNP 10_1101-2021_01_06_425584 343 46 glucose glucose NN 10_1101-2021_01_06_425584 343 47 concentration concentration NN 10_1101-2021_01_06_425584 343 48 induces induce NNS 10_1101-2021_01_06_425584 343 49 endothelial endothelial JJ 10_1101-2021_01_06_425584 343 50 cell cell NN 10_1101-2021_01_06_425584 343 51 proliferation proliferation NN 10_1101-2021_01_06_425584 343 52 by by IN 10_1101-2021_01_06_425584 343 53 regulating regulate VBG 10_1101-2021_01_06_425584 343 54 cyclin cyclin NNP 10_1101-2021_01_06_425584 343 55 - - HYPH 10_1101-2021_01_06_425584 343 56 D2 D2 NNP 10_1101-2021_01_06_425584 343 57 - - HYPH 10_1101-2021_01_06_425584 343 58 582 582 NNP 10_1101-2021_01_06_425584 343 59 related related JJ 10_1101-2021_01_06_425584 343 60 miR-98 mir-98 NN 10_1101-2021_01_06_425584 343 61 . . . 10_1101-2021_01_06_425584 344 1 J J NNP 10_1101-2021_01_06_425584 344 2 Cell Cell NNP 10_1101-2021_01_06_425584 344 3 Mol Mol NNP 10_1101-2021_01_06_425584 344 4 Med Med NNP 10_1101-2021_01_06_425584 344 5 2016 2016 CD 10_1101-2021_01_06_425584 344 6 , , , 10_1101-2021_01_06_425584 344 7 20 20 CD 10_1101-2021_01_06_425584 344 8 , , , 10_1101-2021_01_06_425584 344 9 ( ( -LRB- 10_1101-2021_01_06_425584 344 10 6 6 CD 10_1101-2021_01_06_425584 344 11 ) ) -RRB- 10_1101-2021_01_06_425584 344 12 , , , 10_1101-2021_01_06_425584 344 13 1159 1159 CD 10_1101-2021_01_06_425584 344 14 - - SYM 10_1101-2021_01_06_425584 344 15 69 69 CD 10_1101-2021_01_06_425584 344 16 . . . 10_1101-2021_01_06_425584 345 1 583 583 CD 10_1101-2021_01_06_425584 345 2 17 17 CD 10_1101-2021_01_06_425584 345 3 . . . 10_1101-2021_01_06_425584 346 1 Madonna Madonna NNP 10_1101-2021_01_06_425584 346 2 , , , 10_1101-2021_01_06_425584 346 3 R. R. NNP 10_1101-2021_01_06_425584 346 4 ; ; : 10_1101-2021_01_06_425584 346 5 De De NNP 10_1101-2021_01_06_425584 346 6 Caterina Caterina NNP 10_1101-2021_01_06_425584 346 7 , , , 10_1101-2021_01_06_425584 346 8 R. R. NNP 10_1101-2021_01_06_425584 346 9 , , , 10_1101-2021_01_06_425584 346 10 Prolonged prolonged JJ 10_1101-2021_01_06_425584 346 11 exposure exposure NN 10_1101-2021_01_06_425584 346 12 to to IN 10_1101-2021_01_06_425584 346 13 high high JJ 10_1101-2021_01_06_425584 346 14 insulin insulin NN 10_1101-2021_01_06_425584 346 15 impairs impairs VB 10_1101-2021_01_06_425584 346 16 the the DT 10_1101-2021_01_06_425584 346 17 584 584 CD 10_1101-2021_01_06_425584 346 18 endothelial endothelial JJ 10_1101-2021_01_06_425584 346 19 PI3-kinase pi3-kinase NN 10_1101-2021_01_06_425584 346 20 / / SYM 10_1101-2021_01_06_425584 346 21 Akt Akt NNP 10_1101-2021_01_06_425584 346 22 / / SYM 10_1101-2021_01_06_425584 346 23 nitric nitric JJ 10_1101-2021_01_06_425584 346 24 oxide oxide NN 10_1101-2021_01_06_425584 346 25 signalling signalling NN 10_1101-2021_01_06_425584 346 26 . . . 10_1101-2021_01_06_425584 347 1 Thromb Thromb NNP 10_1101-2021_01_06_425584 347 2 Haemost Haemost NNP 10_1101-2021_01_06_425584 347 3 2009 2009 CD 10_1101-2021_01_06_425584 347 4 , , , 10_1101-2021_01_06_425584 347 5 101 101 CD 10_1101-2021_01_06_425584 347 6 , , , 10_1101-2021_01_06_425584 347 7 ( ( -LRB- 10_1101-2021_01_06_425584 347 8 2 2 CD 10_1101-2021_01_06_425584 347 9 ) ) -RRB- 10_1101-2021_01_06_425584 347 10 , , , 10_1101-2021_01_06_425584 347 11 345 345 CD 10_1101-2021_01_06_425584 347 12 - - SYM 10_1101-2021_01_06_425584 347 13 50 50 CD 10_1101-2021_01_06_425584 347 14 . . . 10_1101-2021_01_06_425584 348 1 585 585 CD 10_1101-2021_01_06_425584 348 2 18 18 CD 10_1101-2021_01_06_425584 348 3 . . . 10_1101-2021_01_06_425584 349 1 Zaccardi Zaccardi NNP 10_1101-2021_01_06_425584 349 2 , , , 10_1101-2021_01_06_425584 349 3 F. F. NNP 10_1101-2021_01_06_425584 349 4 ; ; : 10_1101-2021_01_06_425584 349 5 Webb Webb NNP 10_1101-2021_01_06_425584 349 6 , , , 10_1101-2021_01_06_425584 349 7 D. D. NNP 10_1101-2021_01_06_425584 349 8 R. R. NNP 10_1101-2021_01_06_425584 349 9 ; ; : 10_1101-2021_01_06_425584 349 10 Yates Yates NNP 10_1101-2021_01_06_425584 349 11 , , , 10_1101-2021_01_06_425584 349 12 T. t. NN 10_1101-2021_01_06_425584 349 13 ; ; : 10_1101-2021_01_06_425584 349 14 Davies Davies NNP 10_1101-2021_01_06_425584 349 15 , , , 10_1101-2021_01_06_425584 349 16 M. M. NNP 10_1101-2021_01_06_425584 349 17 J. J. NNP 10_1101-2021_01_06_425584 349 18 , , , 10_1101-2021_01_06_425584 349 19 Pathophysiology Pathophysiology NNP 10_1101-2021_01_06_425584 349 20 of of IN 10_1101-2021_01_06_425584 349 21 type type NN 10_1101-2021_01_06_425584 349 22 1 1 CD 10_1101-2021_01_06_425584 349 23 and and CC 10_1101-2021_01_06_425584 349 24 type type NN 10_1101-2021_01_06_425584 349 25 2 2 CD 10_1101-2021_01_06_425584 349 26 586 586 CD 10_1101-2021_01_06_425584 349 27 diabetes diabetes NN 10_1101-2021_01_06_425584 349 28 mellitus mellitus NN 10_1101-2021_01_06_425584 349 29 : : : 10_1101-2021_01_06_425584 349 30 a a DT 10_1101-2021_01_06_425584 349 31 90-year 90-year CD 10_1101-2021_01_06_425584 349 32 perspective perspective NN 10_1101-2021_01_06_425584 349 33 . . . 10_1101-2021_01_06_425584 350 1 Postgrad Postgrad NNP 10_1101-2021_01_06_425584 350 2 Med Med NNP 10_1101-2021_01_06_425584 350 3 J J NNP 10_1101-2021_01_06_425584 350 4 2016 2016 CD 10_1101-2021_01_06_425584 350 5 , , , 10_1101-2021_01_06_425584 350 6 92 92 CD 10_1101-2021_01_06_425584 350 7 , , , 10_1101-2021_01_06_425584 350 8 ( ( -LRB- 10_1101-2021_01_06_425584 350 9 1084 1084 CD 10_1101-2021_01_06_425584 350 10 ) ) -RRB- 10_1101-2021_01_06_425584 350 11 , , , 10_1101-2021_01_06_425584 350 12 63 63 CD 10_1101-2021_01_06_425584 350 13 - - SYM 10_1101-2021_01_06_425584 350 14 9 9 CD 10_1101-2021_01_06_425584 350 15 . . . 10_1101-2021_01_06_425584 351 1 587 587 CD 10_1101-2021_01_06_425584 351 2 19 19 CD 10_1101-2021_01_06_425584 351 3 . . . 10_1101-2021_01_06_425584 352 1 Moreno Moreno NNP 10_1101-2021_01_06_425584 352 2 - - HYPH 10_1101-2021_01_06_425584 352 3 Ulloa Ulloa NNP 10_1101-2021_01_06_425584 352 4 , , , 10_1101-2021_01_06_425584 352 5 A. a. NN 10_1101-2021_01_06_425584 352 6 ; ; : 10_1101-2021_01_06_425584 352 7 Miranda Miranda NNP 10_1101-2021_01_06_425584 352 8 - - HYPH 10_1101-2021_01_06_425584 352 9 Cervantes Cervantes NNP 10_1101-2021_01_06_425584 352 10 , , , 10_1101-2021_01_06_425584 352 11 A. a. NN 10_1101-2021_01_06_425584 352 12 ; ; : 10_1101-2021_01_06_425584 352 13 Licea Licea NNP 10_1101-2021_01_06_425584 352 14 - - HYPH 10_1101-2021_01_06_425584 352 15 Navarro Navarro NNP 10_1101-2021_01_06_425584 352 16 , , , 10_1101-2021_01_06_425584 352 17 A. a. NN 10_1101-2021_01_06_425584 352 18 ; ; : 10_1101-2021_01_06_425584 352 19 Mansour Mansour NNP 10_1101-2021_01_06_425584 352 20 , , , 10_1101-2021_01_06_425584 352 21 C. C. NNP 10_1101-2021_01_06_425584 352 22 ; ; : 10_1101-2021_01_06_425584 352 23 Beltran-588 Beltran-588 NNP 10_1101-2021_01_06_425584 352 24 Partida Partida NNP 10_1101-2021_01_06_425584 352 25 , , , 10_1101-2021_01_06_425584 352 26 E. E. NNP 10_1101-2021_01_06_425584 352 27 ; ; : 10_1101-2021_01_06_425584 352 28 Donis Donis NNP 10_1101-2021_01_06_425584 352 29 - - HYPH 10_1101-2021_01_06_425584 352 30 Maturano Maturano NNP 10_1101-2021_01_06_425584 352 31 , , , 10_1101-2021_01_06_425584 352 32 L. L. NNP 10_1101-2021_01_06_425584 352 33 ; ; : 10_1101-2021_01_06_425584 352 34 Delgado Delgado NNP 10_1101-2021_01_06_425584 352 35 De De NNP 10_1101-2021_01_06_425584 352 36 la la NNP 10_1101-2021_01_06_425584 352 37 Herran Herran NNP 10_1101-2021_01_06_425584 352 38 , , , 10_1101-2021_01_06_425584 352 39 H. H. NNP 10_1101-2021_01_06_425584 352 40 C. C. NNP 10_1101-2021_01_06_425584 352 41 ; ; : 10_1101-2021_01_06_425584 352 42 Villarreal Villarreal NNP 10_1101-2021_01_06_425584 352 43 , , , 10_1101-2021_01_06_425584 352 44 F. F. NNP 10_1101-2021_01_06_425584 352 45 ; ; : 10_1101-2021_01_06_425584 352 46 Alvarez Alvarez NNP 10_1101-2021_01_06_425584 352 47 - - HYPH 10_1101-2021_01_06_425584 352 48 Delgado Delgado NNP 10_1101-2021_01_06_425584 352 49 , , , 10_1101-2021_01_06_425584 352 50 C. C. NNP 10_1101-2021_01_06_425584 352 51 , , , 10_1101-2021_01_06_425584 352 52 589 589 CD 10_1101-2021_01_06_425584 352 53 ( ( -LRB- 10_1101-2021_01_06_425584 352 54 -)-Epicatechin -)-Epicatechin : 10_1101-2021_01_06_425584 352 55 stimulates stimulate VBZ 10_1101-2021_01_06_425584 352 56 mitochondrial mitochondrial NN 10_1101-2021_01_06_425584 352 57 biogenesis biogenesis NN 10_1101-2021_01_06_425584 352 58 and and CC 10_1101-2021_01_06_425584 352 59 cell cell NN 10_1101-2021_01_06_425584 352 60 growth growth NN 10_1101-2021_01_06_425584 352 61 in in IN 10_1101-2021_01_06_425584 352 62 C2C12 C2C12 NNP 10_1101-2021_01_06_425584 352 63 myotubes myotube NNS 10_1101-2021_01_06_425584 352 64 via via IN 10_1101-2021_01_06_425584 352 65 the the DT 10_1101-2021_01_06_425584 352 66 590 590 CD 10_1101-2021_01_06_425584 352 67 G g NN 10_1101-2021_01_06_425584 352 68 - - HYPH 10_1101-2021_01_06_425584 352 69 protein protein NN 10_1101-2021_01_06_425584 352 70 coupled couple VBN 10_1101-2021_01_06_425584 352 71 estrogen estrogen NNP 10_1101-2021_01_06_425584 352 72 receptor receptor NN 10_1101-2021_01_06_425584 352 73 . . . 10_1101-2021_01_06_425584 353 1 Eur Eur NNP 10_1101-2021_01_06_425584 353 2 J J NNP 10_1101-2021_01_06_425584 353 3 Pharmacol Pharmacol NNP 10_1101-2021_01_06_425584 353 4 2018 2018 CD 10_1101-2021_01_06_425584 353 5 , , , 10_1101-2021_01_06_425584 353 6 822 822 CD 10_1101-2021_01_06_425584 353 7 , , , 10_1101-2021_01_06_425584 353 8 95 95 CD 10_1101-2021_01_06_425584 353 9 - - SYM 10_1101-2021_01_06_425584 353 10 107 107 CD 10_1101-2021_01_06_425584 353 11 . . . 10_1101-2021_01_06_425584 354 1 591 591 CD 10_1101-2021_01_06_425584 354 2 20 20 CD 10_1101-2021_01_06_425584 354 3 . . . 10_1101-2021_01_06_425584 355 1 Kirkwood Kirkwood NNP 10_1101-2021_01_06_425584 355 2 , , , 10_1101-2021_01_06_425584 355 3 J. J. NNP 10_1101-2021_01_06_425584 355 4 S. S. NNP 10_1101-2021_01_06_425584 355 5 ; ; : 10_1101-2021_01_06_425584 355 6 Maier Maier NNP 10_1101-2021_01_06_425584 355 7 , , , 10_1101-2021_01_06_425584 355 8 C. C. NNP 10_1101-2021_01_06_425584 355 9 ; ; : 10_1101-2021_01_06_425584 355 10 Stevens Stevens NNP 10_1101-2021_01_06_425584 355 11 , , , 10_1101-2021_01_06_425584 355 12 J. J. NNP 10_1101-2021_01_06_425584 355 13 F. F. NNP 10_1101-2021_01_06_425584 355 14 , , , 10_1101-2021_01_06_425584 355 15 Simultaneous Simultaneous NNP 10_1101-2021_01_06_425584 355 16 , , , 10_1101-2021_01_06_425584 355 17 untargeted untargeted JJ 10_1101-2021_01_06_425584 355 18 metabolic metabolic JJ 10_1101-2021_01_06_425584 355 19 profiling profile VBG 10_1101-2021_01_06_425584 355 20 592 592 CD 10_1101-2021_01_06_425584 355 21 of of IN 10_1101-2021_01_06_425584 355 22 polar polar JJ 10_1101-2021_01_06_425584 355 23 and and CC 10_1101-2021_01_06_425584 355 24 nonpolar nonpolar JJ 10_1101-2021_01_06_425584 355 25 metabolites metabolite NNS 10_1101-2021_01_06_425584 355 26 by by IN 10_1101-2021_01_06_425584 355 27 LC LC NNP 10_1101-2021_01_06_425584 355 28 - - HYPH 10_1101-2021_01_06_425584 355 29 Q Q NNP 10_1101-2021_01_06_425584 355 30 - - HYPH 10_1101-2021_01_06_425584 355 31 TOF TOF NNP 10_1101-2021_01_06_425584 355 32 mass mass NN 10_1101-2021_01_06_425584 355 33 spectrometry spectrometry NN 10_1101-2021_01_06_425584 355 34 . . . 10_1101-2021_01_06_425584 356 1 Curr Curr NNP 10_1101-2021_01_06_425584 356 2 Protoc Protoc NNP 10_1101-2021_01_06_425584 356 3 Toxicol Toxicol NNP 10_1101-2021_01_06_425584 356 4 2013 2013 CD 10_1101-2021_01_06_425584 356 5 , , , 10_1101-2021_01_06_425584 356 6 593 593 CD 10_1101-2021_01_06_425584 356 7 Chapter chapter NN 10_1101-2021_01_06_425584 356 8 4 4 CD 10_1101-2021_01_06_425584 356 9 , , , 10_1101-2021_01_06_425584 356 10 Unit4 unit4 RB 10_1101-2021_01_06_425584 356 11 39 39 CD 10_1101-2021_01_06_425584 356 12 . . . 10_1101-2021_01_06_425584 357 1 594 594 CD 10_1101-2021_01_06_425584 357 2 21 21 CD 10_1101-2021_01_06_425584 357 3 . . . 10_1101-2021_01_06_425584 358 1 Moreno Moreno NNP 10_1101-2021_01_06_425584 358 2 - - HYPH 10_1101-2021_01_06_425584 358 3 Ulloa Ulloa NNP 10_1101-2021_01_06_425584 358 4 , , , 10_1101-2021_01_06_425584 358 5 A. a. NN 10_1101-2021_01_06_425584 358 6 ; ; : 10_1101-2021_01_06_425584 358 7 Sicairos Sicairos NNP 10_1101-2021_01_06_425584 358 8 Diaz Diaz NNP 10_1101-2021_01_06_425584 358 9 , , , 10_1101-2021_01_06_425584 358 10 V. V. NNP 10_1101-2021_01_06_425584 358 11 ; ; : 10_1101-2021_01_06_425584 358 12 Tejeda Tejeda NNP 10_1101-2021_01_06_425584 358 13 - - HYPH 10_1101-2021_01_06_425584 358 14 Mora Mora NNP 10_1101-2021_01_06_425584 358 15 , , , 10_1101-2021_01_06_425584 358 16 J. J. NNP 10_1101-2021_01_06_425584 359 1 A. a. LS 10_1101-2021_01_06_425584 359 2 ; ; : 10_1101-2021_01_06_425584 359 3 Macias Macias NNP 10_1101-2021_01_06_425584 359 4 Contreras Contreras NNP 10_1101-2021_01_06_425584 359 5 , , , 10_1101-2021_01_06_425584 359 6 M. M. NNP 10_1101-2021_01_06_425584 359 7 I. I. NNP 10_1101-2021_01_06_425584 359 8 ; ; : 10_1101-2021_01_06_425584 359 9 Castillo Castillo NNP 10_1101-2021_01_06_425584 359 10 , , , 10_1101-2021_01_06_425584 359 11 595 595 CD 10_1101-2021_01_06_425584 359 12 F. F. NNP 10_1101-2021_01_06_425584 359 13 D. D. NNP 10_1101-2021_01_06_425584 359 14 ; ; : 10_1101-2021_01_06_425584 359 15 Guerrero Guerrero NNP 10_1101-2021_01_06_425584 359 16 , , , 10_1101-2021_01_06_425584 359 17 A. a. NN 10_1101-2021_01_06_425584 359 18 ; ; : 10_1101-2021_01_06_425584 359 19 Gonzalez Gonzalez NNP 10_1101-2021_01_06_425584 359 20 Sanchez Sanchez NNP 10_1101-2021_01_06_425584 359 21 , , , 10_1101-2021_01_06_425584 359 22 R. R. NNP 10_1101-2021_01_06_425584 359 23 ; ; : 10_1101-2021_01_06_425584 359 24 Mendoza Mendoza NNP 10_1101-2021_01_06_425584 359 25 - - HYPH 10_1101-2021_01_06_425584 359 26 Porras Porras NNP 10_1101-2021_01_06_425584 359 27 , , , 10_1101-2021_01_06_425584 359 28 O. O. NNP 10_1101-2021_01_06_425584 359 29 ; ; : 10_1101-2021_01_06_425584 359 30 Vazquez Vazquez NNP 10_1101-2021_01_06_425584 359 31 Duhalt Duhalt NNP 10_1101-2021_01_06_425584 359 32 , , , 10_1101-2021_01_06_425584 359 33 R. R. NNP 10_1101-2021_01_06_425584 359 34 ; ; : 10_1101-2021_01_06_425584 359 35 Licea-596 Licea-596 NNP 10_1101-2021_01_06_425584 359 36 Navarro Navarro NNP 10_1101-2021_01_06_425584 359 37 , , , 10_1101-2021_01_06_425584 359 38 A. A. NNP 10_1101-2021_01_06_425584 359 39 , , , 10_1101-2021_01_06_425584 359 40 Chemical Chemical NNP 10_1101-2021_01_06_425584 359 41 Profiling Profiling NNP 10_1101-2021_01_06_425584 359 42 Provides provide VBZ 10_1101-2021_01_06_425584 359 43 Insights Insights NNPS 10_1101-2021_01_06_425584 359 44 into into IN 10_1101-2021_01_06_425584 359 45 the the DT 10_1101-2021_01_06_425584 359 46 Metabolic Metabolic NNP 10_1101-2021_01_06_425584 359 47 Machinery Machinery NNP 10_1101-2021_01_06_425584 359 48 of of IN 10_1101-2021_01_06_425584 359 49 Hydrocarbon-597 Hydrocarbon-597 NNP 10_1101-2021_01_06_425584 359 50 Degrading Degrading NNP 10_1101-2021_01_06_425584 359 51 Deep Deep NNP 10_1101-2021_01_06_425584 359 52 - - HYPH 10_1101-2021_01_06_425584 359 53 Sea Sea NNP 10_1101-2021_01_06_425584 359 54 Microbes Microbes NNPS 10_1101-2021_01_06_425584 359 55 . . . 10_1101-2021_01_06_425584 360 1 mSystems mSystems NNP 10_1101-2021_01_06_425584 360 2 2020 2020 CD 10_1101-2021_01_06_425584 360 3 , , , 10_1101-2021_01_06_425584 360 4 5 5 CD 10_1101-2021_01_06_425584 360 5 , , , 10_1101-2021_01_06_425584 360 6 ( ( -LRB- 10_1101-2021_01_06_425584 360 7 6 6 CD 10_1101-2021_01_06_425584 360 8 ) ) -RRB- 10_1101-2021_01_06_425584 360 9 . . . 10_1101-2021_01_06_425584 361 1 598 598 CD 10_1101-2021_01_06_425584 361 2 22 22 CD 10_1101-2021_01_06_425584 361 3 . . . 10_1101-2021_01_06_425584 362 1 Gowda Gowda NNP 10_1101-2021_01_06_425584 362 2 , , , 10_1101-2021_01_06_425584 362 3 H. H. NNP 10_1101-2021_01_06_425584 362 4 ; ; : 10_1101-2021_01_06_425584 362 5 Ivanisevic Ivanisevic NNP 10_1101-2021_01_06_425584 362 6 , , , 10_1101-2021_01_06_425584 362 7 J. J. NNP 10_1101-2021_01_06_425584 362 8 ; ; : 10_1101-2021_01_06_425584 362 9 Johnson Johnson NNP 10_1101-2021_01_06_425584 362 10 , , , 10_1101-2021_01_06_425584 362 11 C. C. NNP 10_1101-2021_01_06_425584 362 12 H. H. NNP 10_1101-2021_01_06_425584 362 13 ; ; : 10_1101-2021_01_06_425584 362 14 Kurczy Kurczy NNP 10_1101-2021_01_06_425584 362 15 , , , 10_1101-2021_01_06_425584 362 16 M. M. NNP 10_1101-2021_01_06_425584 362 17 E. E. NNP 10_1101-2021_01_06_425584 362 18 ; ; : 10_1101-2021_01_06_425584 362 19 Benton Benton NNP 10_1101-2021_01_06_425584 362 20 , , , 10_1101-2021_01_06_425584 362 21 H. H. NNP 10_1101-2021_01_06_425584 362 22 P. P. NNP 10_1101-2021_01_06_425584 362 23 ; ; : 10_1101-2021_01_06_425584 362 24 Rinehart Rinehart NNP 10_1101-2021_01_06_425584 362 25 , , , 10_1101-2021_01_06_425584 362 26 D. D. NNP 10_1101-2021_01_06_425584 362 27 ; ; : 10_1101-2021_01_06_425584 362 28 599 599 CD 10_1101-2021_01_06_425584 362 29 Nguyen Nguyen NNP 10_1101-2021_01_06_425584 362 30 , , , 10_1101-2021_01_06_425584 362 31 T. T. NNP 10_1101-2021_01_06_425584 362 32 ; ; : 10_1101-2021_01_06_425584 362 33 Ray Ray NNP 10_1101-2021_01_06_425584 362 34 , , , 10_1101-2021_01_06_425584 362 35 J. J. NNP 10_1101-2021_01_06_425584 362 36 ; ; : 10_1101-2021_01_06_425584 362 37 Kuehl Kuehl NNP 10_1101-2021_01_06_425584 362 38 , , , 10_1101-2021_01_06_425584 362 39 J. J. NNP 10_1101-2021_01_06_425584 362 40 ; ; : 10_1101-2021_01_06_425584 362 41 Arevalo Arevalo NNP 10_1101-2021_01_06_425584 362 42 , , , 10_1101-2021_01_06_425584 362 43 B. B. NNP 10_1101-2021_01_06_425584 362 44 ; ; : 10_1101-2021_01_06_425584 362 45 Westenskow Westenskow NNP 10_1101-2021_01_06_425584 362 46 , , , 10_1101-2021_01_06_425584 362 47 P. P. NNP 10_1101-2021_01_06_425584 362 48 D. D. NNP 10_1101-2021_01_06_425584 362 49 ; ; : 10_1101-2021_01_06_425584 362 50 Wang Wang NNP 10_1101-2021_01_06_425584 362 51 , , , 10_1101-2021_01_06_425584 362 52 J. J. NNP 10_1101-2021_01_06_425584 362 53 ; ; : 10_1101-2021_01_06_425584 362 54 Arkin Arkin NNP 10_1101-2021_01_06_425584 362 55 , , , 10_1101-2021_01_06_425584 362 56 A. a. NN 10_1101-2021_01_06_425584 362 57 P. P. NNP 10_1101-2021_01_06_425584 362 58 ; ; : 10_1101-2021_01_06_425584 362 59 600 600 CD 10_1101-2021_01_06_425584 362 60 Deutschbauer Deutschbauer NNP 10_1101-2021_01_06_425584 362 61 , , , 10_1101-2021_01_06_425584 362 62 A. a. NN 10_1101-2021_01_06_425584 362 63 M. M. NNP 10_1101-2021_01_06_425584 362 64 ; ; : 10_1101-2021_01_06_425584 362 65 Patti Patti NNP 10_1101-2021_01_06_425584 362 66 , , , 10_1101-2021_01_06_425584 362 67 G. G. NNP 10_1101-2021_01_06_425584 362 68 J. J. NNP 10_1101-2021_01_06_425584 362 69 ; ; : 10_1101-2021_01_06_425584 362 70 Siuzdak Siuzdak NNP 10_1101-2021_01_06_425584 362 71 , , , 10_1101-2021_01_06_425584 362 72 G. G. NNP 10_1101-2021_01_06_425584 362 73 , , , 10_1101-2021_01_06_425584 362 74 Interactive Interactive NNP 10_1101-2021_01_06_425584 362 75 XCMS XCMS NNP 10_1101-2021_01_06_425584 362 76 Online online RB 10_1101-2021_01_06_425584 362 77 : : : 10_1101-2021_01_06_425584 362 78 simplifying simplify VBG 10_1101-2021_01_06_425584 362 79 advanced advanced JJ 10_1101-2021_01_06_425584 362 80 601 601 CD 10_1101-2021_01_06_425584 362 81 metabolomic metabolomic JJ 10_1101-2021_01_06_425584 362 82 data datum NNS 10_1101-2021_01_06_425584 362 83 processing processing NN 10_1101-2021_01_06_425584 362 84 and and CC 10_1101-2021_01_06_425584 362 85 subsequent subsequent JJ 10_1101-2021_01_06_425584 362 86 statistical statistical JJ 10_1101-2021_01_06_425584 362 87 analyses analysis NNS 10_1101-2021_01_06_425584 362 88 . . . 10_1101-2021_01_06_425584 363 1 Anal Anal NNP 10_1101-2021_01_06_425584 363 2 Chem Chem NNP 10_1101-2021_01_06_425584 363 3 2014 2014 CD 10_1101-2021_01_06_425584 363 4 , , , 10_1101-2021_01_06_425584 363 5 86 86 CD 10_1101-2021_01_06_425584 363 6 , , , 10_1101-2021_01_06_425584 363 7 ( ( -LRB- 10_1101-2021_01_06_425584 363 8 14 14 CD 10_1101-2021_01_06_425584 363 9 ) ) -RRB- 10_1101-2021_01_06_425584 363 10 , , , 10_1101-2021_01_06_425584 363 11 602 602 CD 10_1101-2021_01_06_425584 363 12 6931 6931 CD 10_1101-2021_01_06_425584 363 13 - - SYM 10_1101-2021_01_06_425584 363 14 9 9 CD 10_1101-2021_01_06_425584 363 15 . . . 10_1101-2021_01_06_425584 364 1 603 603 CD 10_1101-2021_01_06_425584 364 2 23 23 CD 10_1101-2021_01_06_425584 364 3 . . . 10_1101-2021_01_06_425584 365 1 Pluskal Pluskal NNP 10_1101-2021_01_06_425584 365 2 , , , 10_1101-2021_01_06_425584 365 3 T. t. NN 10_1101-2021_01_06_425584 365 4 ; ; : 10_1101-2021_01_06_425584 365 5 Castillo Castillo NNP 10_1101-2021_01_06_425584 365 6 , , , 10_1101-2021_01_06_425584 365 7 S. S. NNP 10_1101-2021_01_06_425584 365 8 ; ; : 10_1101-2021_01_06_425584 365 9 Villar Villar NNP 10_1101-2021_01_06_425584 365 10 - - HYPH 10_1101-2021_01_06_425584 365 11 Briones Briones NNP 10_1101-2021_01_06_425584 365 12 , , , 10_1101-2021_01_06_425584 365 13 A. a. NN 10_1101-2021_01_06_425584 365 14 ; ; : 10_1101-2021_01_06_425584 365 15 Oresic Oresic NNP 10_1101-2021_01_06_425584 365 16 , , , 10_1101-2021_01_06_425584 365 17 M. M. NNP 10_1101-2021_01_06_425584 365 18 , , , 10_1101-2021_01_06_425584 365 19 MZmine MZmine NNP 10_1101-2021_01_06_425584 365 20 2 2 CD 10_1101-2021_01_06_425584 365 21 : : : 10_1101-2021_01_06_425584 365 22 modular modular JJ 10_1101-2021_01_06_425584 365 23 framework framework NN 10_1101-2021_01_06_425584 365 24 for for IN 10_1101-2021_01_06_425584 365 25 604 604 CD 10_1101-2021_01_06_425584 365 26 processing processing NN 10_1101-2021_01_06_425584 365 27 , , , 10_1101-2021_01_06_425584 365 28 visualizing visualizing NN 10_1101-2021_01_06_425584 365 29 , , , 10_1101-2021_01_06_425584 365 30 and and CC 10_1101-2021_01_06_425584 365 31 analyzing analyze VBG 10_1101-2021_01_06_425584 365 32 mass mass NN 10_1101-2021_01_06_425584 365 33 spectrometry spectrometry NN 10_1101-2021_01_06_425584 365 34 - - HYPH 10_1101-2021_01_06_425584 365 35 based base VBN 10_1101-2021_01_06_425584 365 36 molecular molecular JJ 10_1101-2021_01_06_425584 365 37 profile profile NN 10_1101-2021_01_06_425584 365 38 data datum NNS 10_1101-2021_01_06_425584 365 39 . . . 10_1101-2021_01_06_425584 366 1 BMC BMC NNP 10_1101-2021_01_06_425584 366 2 605 605 CD 10_1101-2021_01_06_425584 366 3 Bioinformatics Bioinformatics NNP 10_1101-2021_01_06_425584 366 4 2010 2010 CD 10_1101-2021_01_06_425584 366 5 , , , 10_1101-2021_01_06_425584 366 6 11 11 CD 10_1101-2021_01_06_425584 366 7 , , , 10_1101-2021_01_06_425584 366 8 395 395 CD 10_1101-2021_01_06_425584 366 9 . . . 10_1101-2021_01_06_425584 367 1 606 606 CD 10_1101-2021_01_06_425584 367 2 24 24 CD 10_1101-2021_01_06_425584 367 3 . . . 10_1101-2021_01_06_425584 368 1 Aron Aron NNP 10_1101-2021_01_06_425584 368 2 , , , 10_1101-2021_01_06_425584 368 3 A. a. NN 10_1101-2021_01_06_425584 368 4 T. t. XX 10_1101-2021_01_06_425584 368 5 ; ; : 10_1101-2021_01_06_425584 368 6 Gentry Gentry NNP 10_1101-2021_01_06_425584 368 7 , , , 10_1101-2021_01_06_425584 368 8 E. E. NNP 10_1101-2021_01_06_425584 368 9 C. C. NNP 10_1101-2021_01_06_425584 368 10 ; ; : 10_1101-2021_01_06_425584 368 11 McPhail McPhail NNP 10_1101-2021_01_06_425584 368 12 , , , 10_1101-2021_01_06_425584 368 13 K. K. NNP 10_1101-2021_01_06_425584 368 14 L. L. NNP 10_1101-2021_01_06_425584 368 15 ; ; : 10_1101-2021_01_06_425584 368 16 Nothias Nothias NNP 10_1101-2021_01_06_425584 368 17 , , , 10_1101-2021_01_06_425584 368 18 L. L. NNP 10_1101-2021_01_06_425584 368 19 F. F. NNP 10_1101-2021_01_06_425584 368 20 ; ; : 10_1101-2021_01_06_425584 368 21 Nothias Nothias NNP 10_1101-2021_01_06_425584 368 22 - - HYPH 10_1101-2021_01_06_425584 368 23 Esposito Esposito NNP 10_1101-2021_01_06_425584 368 24 , , , 10_1101-2021_01_06_425584 368 25 M. M. NNP 10_1101-2021_01_06_425584 368 26 ; ; : 10_1101-2021_01_06_425584 368 27 607 607 CD 10_1101-2021_01_06_425584 368 28 Bouslimani Bouslimani NNP 10_1101-2021_01_06_425584 368 29 , , , 10_1101-2021_01_06_425584 368 30 A. a. NN 10_1101-2021_01_06_425584 368 31 ; ; : 10_1101-2021_01_06_425584 368 32 Petras Petras NNP 10_1101-2021_01_06_425584 368 33 , , , 10_1101-2021_01_06_425584 368 34 D. D. NNP 10_1101-2021_01_06_425584 368 35 ; ; : 10_1101-2021_01_06_425584 368 36 Gauglitz Gauglitz NNP 10_1101-2021_01_06_425584 368 37 , , , 10_1101-2021_01_06_425584 368 38 J. J. NNP 10_1101-2021_01_06_425584 368 39 M. M. NNP 10_1101-2021_01_06_425584 368 40 ; ; : 10_1101-2021_01_06_425584 368 41 Sikora Sikora NNP 10_1101-2021_01_06_425584 368 42 , , , 10_1101-2021_01_06_425584 368 43 N. N. NNP 10_1101-2021_01_06_425584 368 44 ; ; : 10_1101-2021_01_06_425584 368 45 Vargas Vargas NNP 10_1101-2021_01_06_425584 368 46 , , , 10_1101-2021_01_06_425584 368 47 F. F. NNP 10_1101-2021_01_06_425584 368 48 ; ; : 10_1101-2021_01_06_425584 368 49 van van NNP 10_1101-2021_01_06_425584 368 50 der der NNP 10_1101-2021_01_06_425584 368 51 Hooft Hooft NNP 10_1101-2021_01_06_425584 368 52 , , , 10_1101-2021_01_06_425584 368 53 J. J. NNP 10_1101-2021_01_06_425584 368 54 J. J. NNP 10_1101-2021_01_06_425584 368 55 J. J. NNP 10_1101-2021_01_06_425584 368 56 ; ; : 10_1101-2021_01_06_425584 368 57 Ernst Ernst NNP 10_1101-2021_01_06_425584 368 58 , , , 10_1101-2021_01_06_425584 368 59 608 608 CD 10_1101-2021_01_06_425584 368 60 M. M. NNP 10_1101-2021_01_06_425584 368 61 ; ; : 10_1101-2021_01_06_425584 368 62 Kang Kang NNP 10_1101-2021_01_06_425584 368 63 , , , 10_1101-2021_01_06_425584 368 64 K. K. NNP 10_1101-2021_01_06_425584 368 65 B. B. NNP 10_1101-2021_01_06_425584 368 66 ; ; : 10_1101-2021_01_06_425584 368 67 Aceves Aceves NNP 10_1101-2021_01_06_425584 368 68 , , , 10_1101-2021_01_06_425584 368 69 C. C. NNP 10_1101-2021_01_06_425584 368 70 M. M. NNP 10_1101-2021_01_06_425584 368 71 ; ; : 10_1101-2021_01_06_425584 368 72 Caraballo Caraballo NNP 10_1101-2021_01_06_425584 368 73 - - HYPH 10_1101-2021_01_06_425584 368 74 Rodriguez Rodriguez NNP 10_1101-2021_01_06_425584 368 75 , , , 10_1101-2021_01_06_425584 368 76 A. a. NN 10_1101-2021_01_06_425584 368 77 M. M. NNP 10_1101-2021_01_06_425584 368 78 ; ; : 10_1101-2021_01_06_425584 368 79 Koester Koester NNP 10_1101-2021_01_06_425584 368 80 , , , 10_1101-2021_01_06_425584 368 81 I. i. NN 10_1101-2021_01_06_425584 368 82 ; ; : 10_1101-2021_01_06_425584 368 83 Weldon Weldon NNP 10_1101-2021_01_06_425584 368 84 , , , 10_1101-2021_01_06_425584 368 85 K. K. NNP 10_1101-2021_01_06_425584 368 86 C. C. NNP 10_1101-2021_01_06_425584 368 87 ; ; : 10_1101-2021_01_06_425584 368 88 609 609 CD 10_1101-2021_01_06_425584 368 89 Bertrand Bertrand NNP 10_1101-2021_01_06_425584 368 90 , , , 10_1101-2021_01_06_425584 368 91 S. S. NNP 10_1101-2021_01_06_425584 368 92 ; ; : 10_1101-2021_01_06_425584 368 93 Roullier Roullier NNP 10_1101-2021_01_06_425584 368 94 , , , 10_1101-2021_01_06_425584 368 95 C. C. NNP 10_1101-2021_01_06_425584 368 96 ; ; : 10_1101-2021_01_06_425584 368 97 Sun Sun NNP 10_1101-2021_01_06_425584 368 98 , , , 10_1101-2021_01_06_425584 368 99 K. K. NNP 10_1101-2021_01_06_425584 368 100 ; ; : 10_1101-2021_01_06_425584 368 101 Tehan Tehan NNP 10_1101-2021_01_06_425584 368 102 , , , 10_1101-2021_01_06_425584 368 103 R. R. NNP 10_1101-2021_01_06_425584 368 104 M. M. NNP 10_1101-2021_01_06_425584 368 105 ; ; : 10_1101-2021_01_06_425584 368 106 Boya Boya NNP 10_1101-2021_01_06_425584 368 107 , , , 10_1101-2021_01_06_425584 368 108 P. P. NNP 10_1101-2021_01_06_425584 368 109 C. C. NNP 10_1101-2021_01_06_425584 368 110 ; ; : 10_1101-2021_01_06_425584 368 111 Christian Christian NNP 10_1101-2021_01_06_425584 368 112 , , , 10_1101-2021_01_06_425584 368 113 M. M. NNP 10_1101-2021_01_06_425584 368 114 H. H. NNP 10_1101-2021_01_06_425584 368 115 ; ; : 10_1101-2021_01_06_425584 368 116 Gutierrez Gutierrez NNP 10_1101-2021_01_06_425584 368 117 , , , 10_1101-2021_01_06_425584 368 118 M. M. NNP 10_1101-2021_01_06_425584 368 119 ; ; : 10_1101-2021_01_06_425584 368 120 610 610 CD 10_1101-2021_01_06_425584 368 121 Ulloa Ulloa NNP 10_1101-2021_01_06_425584 368 122 , , , 10_1101-2021_01_06_425584 368 123 A. a. NN 10_1101-2021_01_06_425584 368 124 M. M. NNP 10_1101-2021_01_06_425584 368 125 ; ; : 10_1101-2021_01_06_425584 368 126 Tejeda Tejeda NNP 10_1101-2021_01_06_425584 368 127 Mora Mora NNP 10_1101-2021_01_06_425584 368 128 , , , 10_1101-2021_01_06_425584 368 129 J. J. NNP 10_1101-2021_01_06_425584 369 1 A. a. LS 10_1101-2021_01_06_425584 369 2 ; ; : 10_1101-2021_01_06_425584 369 3 Mojica Mojica NNP 10_1101-2021_01_06_425584 369 4 - - HYPH 10_1101-2021_01_06_425584 369 5 Flores Flores NNP 10_1101-2021_01_06_425584 369 6 , , , 10_1101-2021_01_06_425584 369 7 R. R. NNP 10_1101-2021_01_06_425584 369 8 ; ; : 10_1101-2021_01_06_425584 369 9 Lakey Lakey NNP 10_1101-2021_01_06_425584 369 10 - - HYPH 10_1101-2021_01_06_425584 369 11 Beitia Beitia NNP 10_1101-2021_01_06_425584 369 12 , , , 10_1101-2021_01_06_425584 369 13 J. J. NNP 10_1101-2021_01_06_425584 369 14 ; ; : 10_1101-2021_01_06_425584 369 15 Vasquez Vasquez NNP 10_1101-2021_01_06_425584 369 16 - - HYPH 10_1101-2021_01_06_425584 369 17 Chaves Chaves NNPS 10_1101-2021_01_06_425584 369 18 , , , 10_1101-2021_01_06_425584 369 19 V. V. NNP 10_1101-2021_01_06_425584 369 20 ; ; : 10_1101-2021_01_06_425584 369 21 611 611 CD 10_1101-2021_01_06_425584 369 22 Zhang Zhang NNP 10_1101-2021_01_06_425584 369 23 , , , 10_1101-2021_01_06_425584 369 24 Y. Y. NNP 10_1101-2021_01_06_425584 369 25 ; ; : 10_1101-2021_01_06_425584 369 26 Calderon Calderon NNP 10_1101-2021_01_06_425584 369 27 , , , 10_1101-2021_01_06_425584 369 28 A. a. NN 10_1101-2021_01_06_425584 369 29 I. i. NN 10_1101-2021_01_06_425584 369 30 ; ; : 10_1101-2021_01_06_425584 369 31 Tayler Tayler NNP 10_1101-2021_01_06_425584 369 32 , , , 10_1101-2021_01_06_425584 369 33 N. N. NNP 10_1101-2021_01_06_425584 369 34 ; ; : 10_1101-2021_01_06_425584 369 35 Keyzers Keyzers NNP 10_1101-2021_01_06_425584 369 36 , , , 10_1101-2021_01_06_425584 369 37 R. R. NNP 10_1101-2021_01_06_425584 369 38 A. a. NN 10_1101-2021_01_06_425584 369 39 ; ; : 10_1101-2021_01_06_425584 369 40 Tugizimana Tugizimana NNP 10_1101-2021_01_06_425584 369 41 , , , 10_1101-2021_01_06_425584 369 42 F. F. NNP 10_1101-2021_01_06_425584 369 43 ; ; : 10_1101-2021_01_06_425584 369 44 Ndlovu Ndlovu NNP 10_1101-2021_01_06_425584 369 45 , , , 10_1101-2021_01_06_425584 369 46 N. N. NNP 10_1101-2021_01_06_425584 369 47 ; ; : 10_1101-2021_01_06_425584 369 48 Aksenov Aksenov NNP 10_1101-2021_01_06_425584 369 49 , , , 10_1101-2021_01_06_425584 369 50 A. a. NN 10_1101-2021_01_06_425584 370 1 612 612 CD 10_1101-2021_01_06_425584 370 2 A. a. NN 10_1101-2021_01_06_425584 370 3 ; ; : 10_1101-2021_01_06_425584 370 4 Jarmusch Jarmusch NNP 10_1101-2021_01_06_425584 370 5 , , , 10_1101-2021_01_06_425584 370 6 A. A. NNP 10_1101-2021_01_06_425584 370 7 K. K. NNP 10_1101-2021_01_06_425584 370 8 ; ; : 10_1101-2021_01_06_425584 370 9 Schmid Schmid NNP 10_1101-2021_01_06_425584 370 10 , , , 10_1101-2021_01_06_425584 370 11 R. R. NNP 10_1101-2021_01_06_425584 370 12 ; ; : 10_1101-2021_01_06_425584 370 13 Truman Truman NNP 10_1101-2021_01_06_425584 370 14 , , , 10_1101-2021_01_06_425584 370 15 A. a. NN 10_1101-2021_01_06_425584 370 16 W. W. NNP 10_1101-2021_01_06_425584 370 17 ; ; : 10_1101-2021_01_06_425584 370 18 Bandeira Bandeira NNP 10_1101-2021_01_06_425584 370 19 , , , 10_1101-2021_01_06_425584 370 20 N. N. NNP 10_1101-2021_01_06_425584 370 21 ; ; : 10_1101-2021_01_06_425584 370 22 Wang Wang NNP 10_1101-2021_01_06_425584 370 23 , , , 10_1101-2021_01_06_425584 370 24 M. M. NNP 10_1101-2021_01_06_425584 370 25 ; ; : 10_1101-2021_01_06_425584 370 26 Dorrestein Dorrestein NNP 10_1101-2021_01_06_425584 370 27 , , , 10_1101-2021_01_06_425584 370 28 P. P. NNP 10_1101-2021_01_06_425584 370 29 C. C. NNP 10_1101-2021_01_06_425584 370 30 , , , 10_1101-2021_01_06_425584 370 31 613 613 CD 10_1101-2021_01_06_425584 370 32 Reproducible reproducible NN 10_1101-2021_01_06_425584 370 33 molecular molecular JJ 10_1101-2021_01_06_425584 370 34 networking networking NN 10_1101-2021_01_06_425584 370 35 of of IN 10_1101-2021_01_06_425584 370 36 untargeted untargeted JJ 10_1101-2021_01_06_425584 370 37 mass mass JJ 10_1101-2021_01_06_425584 370 38 spectrometry spectrometry NN 10_1101-2021_01_06_425584 370 39 data datum NNS 10_1101-2021_01_06_425584 370 40 using use VBG 10_1101-2021_01_06_425584 370 41 GNPS gnps NN 10_1101-2021_01_06_425584 370 42 . . . 10_1101-2021_01_06_425584 371 1 Nat Nat NNP 10_1101-2021_01_06_425584 371 2 614 614 CD 10_1101-2021_01_06_425584 371 3 Protoc Protoc NNP 10_1101-2021_01_06_425584 371 4 2020 2020 CD 10_1101-2021_01_06_425584 371 5 . . . 10_1101-2021_01_06_425584 372 1 615 615 CD 10_1101-2021_01_06_425584 372 2 25 25 CD 10_1101-2021_01_06_425584 372 3 . . . 10_1101-2021_01_06_425584 372 4 da da NNP 10_1101-2021_01_06_425584 372 5 Silva Silva NNP 10_1101-2021_01_06_425584 372 6 , , , 10_1101-2021_01_06_425584 372 7 R. R. NNP 10_1101-2021_01_06_425584 372 8 R. R. NNP 10_1101-2021_01_06_425584 372 9 ; ; : 10_1101-2021_01_06_425584 372 10 Wang Wang NNP 10_1101-2021_01_06_425584 372 11 , , , 10_1101-2021_01_06_425584 372 12 M. M. NNP 10_1101-2021_01_06_425584 372 13 ; ; : 10_1101-2021_01_06_425584 372 14 Nothias Nothias NNP 10_1101-2021_01_06_425584 372 15 , , , 10_1101-2021_01_06_425584 372 16 L. L. NNP 10_1101-2021_01_06_425584 372 17 F. F. NNP 10_1101-2021_01_06_425584 372 18 ; ; : 10_1101-2021_01_06_425584 372 19 van van NNP 10_1101-2021_01_06_425584 372 20 der der NNP 10_1101-2021_01_06_425584 372 21 Hooft Hooft NNP 10_1101-2021_01_06_425584 372 22 , , , 10_1101-2021_01_06_425584 372 23 J. J. NNP 10_1101-2021_01_06_425584 372 24 J. J. NNP 10_1101-2021_01_06_425584 372 25 J. J. NNP 10_1101-2021_01_06_425584 372 26 ; ; : 10_1101-2021_01_06_425584 372 27 Caraballo Caraballo NNP 10_1101-2021_01_06_425584 372 28 - - HYPH 10_1101-2021_01_06_425584 372 29 Rodriguez Rodriguez NNP 10_1101-2021_01_06_425584 372 30 , , , 10_1101-2021_01_06_425584 372 31 A. a. NN 10_1101-2021_01_06_425584 373 1 616 616 CD 10_1101-2021_01_06_425584 373 2 M. M. NNP 10_1101-2021_01_06_425584 373 3 ; ; : 10_1101-2021_01_06_425584 373 4 Fox Fox NNP 10_1101-2021_01_06_425584 373 5 , , , 10_1101-2021_01_06_425584 373 6 E. E. NNP 10_1101-2021_01_06_425584 373 7 ; ; : 10_1101-2021_01_06_425584 373 8 Balunas Balunas NNP 10_1101-2021_01_06_425584 373 9 , , , 10_1101-2021_01_06_425584 373 10 M. M. NNP 10_1101-2021_01_06_425584 373 11 J. J. NNP 10_1101-2021_01_06_425584 373 12 ; ; : 10_1101-2021_01_06_425584 373 13 Klassen Klassen NNP 10_1101-2021_01_06_425584 373 14 , , , 10_1101-2021_01_06_425584 373 15 J. J. NNP 10_1101-2021_01_06_425584 373 16 L. L. NNP 10_1101-2021_01_06_425584 373 17 ; ; : 10_1101-2021_01_06_425584 373 18 Lopes Lopes NNP 10_1101-2021_01_06_425584 373 19 , , , 10_1101-2021_01_06_425584 373 20 N. N. NNP 10_1101-2021_01_06_425584 373 21 P. P. NNP 10_1101-2021_01_06_425584 373 22 ; ; : 10_1101-2021_01_06_425584 373 23 Dorrestein Dorrestein NNP 10_1101-2021_01_06_425584 373 24 , , , 10_1101-2021_01_06_425584 373 25 P. P. NNP 10_1101-2021_01_06_425584 373 26 C. C. NNP 10_1101-2021_01_06_425584 373 27 , , , 10_1101-2021_01_06_425584 373 28 Propagating propagate VBG 10_1101-2021_01_06_425584 373 29 617 617 CD 10_1101-2021_01_06_425584 373 30 annotations annotation NNS 10_1101-2021_01_06_425584 373 31 of of IN 10_1101-2021_01_06_425584 373 32 molecular molecular JJ 10_1101-2021_01_06_425584 373 33 networks network NNS 10_1101-2021_01_06_425584 373 34 using use VBG 10_1101-2021_01_06_425584 373 35 in in IN 10_1101-2021_01_06_425584 373 36 silico silico NNP 10_1101-2021_01_06_425584 373 37 fragmentation fragmentation NN 10_1101-2021_01_06_425584 373 38 . . . 10_1101-2021_01_06_425584 374 1 PLoS PLoS : 10_1101-2021_01_06_425584 374 2 Comput Comput NNP 10_1101-2021_01_06_425584 374 3 Biol Biol NNP 10_1101-2021_01_06_425584 374 4 2018 2018 CD 10_1101-2021_01_06_425584 374 5 , , , 10_1101-2021_01_06_425584 374 6 14 14 CD 10_1101-2021_01_06_425584 374 7 , , , 10_1101-2021_01_06_425584 374 8 618 618 CD 10_1101-2021_01_06_425584 374 9 ( ( -LRB- 10_1101-2021_01_06_425584 374 10 4 4 CD 10_1101-2021_01_06_425584 374 11 ) ) -RRB- 10_1101-2021_01_06_425584 374 12 , , , 10_1101-2021_01_06_425584 374 13 e1006089 e1006089 NNP 10_1101-2021_01_06_425584 374 14 . . . 10_1101-2021_01_06_425584 375 1 619 619 CD 10_1101-2021_01_06_425584 375 2 26 26 CD 10_1101-2021_01_06_425584 375 3 . . . 10_1101-2021_01_06_425584 375 4 van van NNP 10_1101-2021_01_06_425584 375 5 der der NNP 10_1101-2021_01_06_425584 375 6 Hooft Hooft NNP 10_1101-2021_01_06_425584 375 7 , , , 10_1101-2021_01_06_425584 375 8 J. J. NNP 10_1101-2021_01_06_425584 375 9 J. J. NNP 10_1101-2021_01_06_425584 375 10 ; ; : 10_1101-2021_01_06_425584 375 11 Wandy Wandy NNP 10_1101-2021_01_06_425584 375 12 , , , 10_1101-2021_01_06_425584 375 13 J. J. NNP 10_1101-2021_01_06_425584 375 14 ; ; : 10_1101-2021_01_06_425584 375 15 Barrett Barrett NNP 10_1101-2021_01_06_425584 375 16 , , , 10_1101-2021_01_06_425584 375 17 M. M. NNP 10_1101-2021_01_06_425584 375 18 P. P. NNP 10_1101-2021_01_06_425584 375 19 ; ; : 10_1101-2021_01_06_425584 375 20 Burgess Burgess NNP 10_1101-2021_01_06_425584 375 21 , , , 10_1101-2021_01_06_425584 375 22 K. K. NNP 10_1101-2021_01_06_425584 375 23 E. E. NNP 10_1101-2021_01_06_425584 375 24 ; ; : 10_1101-2021_01_06_425584 375 25 Rogers Rogers NNP 10_1101-2021_01_06_425584 375 26 , , , 10_1101-2021_01_06_425584 375 27 S. S. NNP 10_1101-2021_01_06_425584 375 28 , , , 10_1101-2021_01_06_425584 375 29 Topic Topic NNP 10_1101-2021_01_06_425584 375 30 620 620 CD 10_1101-2021_01_06_425584 375 31 modeling model VBG 10_1101-2021_01_06_425584 375 32 for for IN 10_1101-2021_01_06_425584 375 33 untargeted untargeted JJ 10_1101-2021_01_06_425584 375 34 substructure substructure NN 10_1101-2021_01_06_425584 375 35 exploration exploration NN 10_1101-2021_01_06_425584 375 36 in in IN 10_1101-2021_01_06_425584 375 37 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 375 38 . . . 10_1101-2021_01_06_425584 376 1 Proc Proc NNP 10_1101-2021_01_06_425584 376 2 Natl Natl NNP 10_1101-2021_01_06_425584 376 3 Acad Acad NNP 10_1101-2021_01_06_425584 376 4 Sci Sci NNP 10_1101-2021_01_06_425584 376 5 U U NNP 10_1101-2021_01_06_425584 376 6 S S NNP 10_1101-2021_01_06_425584 376 7 A A NNP 10_1101-2021_01_06_425584 376 8 621 621 CD 10_1101-2021_01_06_425584 376 9 2016 2016 CD 10_1101-2021_01_06_425584 376 10 , , , 10_1101-2021_01_06_425584 376 11 113 113 CD 10_1101-2021_01_06_425584 376 12 , , , 10_1101-2021_01_06_425584 376 13 ( ( -LRB- 10_1101-2021_01_06_425584 376 14 48 48 CD 10_1101-2021_01_06_425584 376 15 ) ) -RRB- 10_1101-2021_01_06_425584 376 16 , , , 10_1101-2021_01_06_425584 376 17 13738 13738 CD 10_1101-2021_01_06_425584 376 18 - - SYM 10_1101-2021_01_06_425584 376 19 13743 13743 CD 10_1101-2021_01_06_425584 376 20 . . . 10_1101-2021_01_06_425584 377 1 622 622 CD 10_1101-2021_01_06_425584 377 2 27 27 CD 10_1101-2021_01_06_425584 377 3 . . . 10_1101-2021_01_06_425584 378 1 Djoumbou Djoumbou NNP 10_1101-2021_01_06_425584 378 2 Feunang Feunang NNP 10_1101-2021_01_06_425584 378 3 , , , 10_1101-2021_01_06_425584 378 4 Y. Y. NNP 10_1101-2021_01_06_425584 378 5 ; ; : 10_1101-2021_01_06_425584 378 6 Eisner Eisner NNP 10_1101-2021_01_06_425584 378 7 , , , 10_1101-2021_01_06_425584 378 8 R. R. NNP 10_1101-2021_01_06_425584 378 9 ; ; : 10_1101-2021_01_06_425584 378 10 Knox Knox NNP 10_1101-2021_01_06_425584 378 11 , , , 10_1101-2021_01_06_425584 378 12 C. C. NNP 10_1101-2021_01_06_425584 378 13 ; ; : 10_1101-2021_01_06_425584 378 14 Chepelev Chepelev NNP 10_1101-2021_01_06_425584 378 15 , , , 10_1101-2021_01_06_425584 378 16 L. L. NNP 10_1101-2021_01_06_425584 378 17 ; ; : 10_1101-2021_01_06_425584 378 18 Hastings Hastings NNP 10_1101-2021_01_06_425584 378 19 , , , 10_1101-2021_01_06_425584 378 20 J. J. NNP 10_1101-2021_01_06_425584 378 21 ; ; : 10_1101-2021_01_06_425584 378 22 Owen Owen NNP 10_1101-2021_01_06_425584 378 23 , , , 10_1101-2021_01_06_425584 378 24 G. G. NNP 10_1101-2021_01_06_425584 378 25 ; ; : 10_1101-2021_01_06_425584 378 26 623 623 CD 10_1101-2021_01_06_425584 378 27 Fahy Fahy NNP 10_1101-2021_01_06_425584 378 28 , , , 10_1101-2021_01_06_425584 378 29 E. E. NNP 10_1101-2021_01_06_425584 378 30 ; ; : 10_1101-2021_01_06_425584 378 31 Steinbeck Steinbeck NNP 10_1101-2021_01_06_425584 378 32 , , , 10_1101-2021_01_06_425584 378 33 C. C. NNP 10_1101-2021_01_06_425584 378 34 ; ; : 10_1101-2021_01_06_425584 378 35 Subramanian Subramanian NNP 10_1101-2021_01_06_425584 378 36 , , , 10_1101-2021_01_06_425584 378 37 S. S. NNP 10_1101-2021_01_06_425584 378 38 ; ; : 10_1101-2021_01_06_425584 378 39 Bolton Bolton NNP 10_1101-2021_01_06_425584 378 40 , , , 10_1101-2021_01_06_425584 378 41 E. E. NNP 10_1101-2021_01_06_425584 378 42 ; ; : 10_1101-2021_01_06_425584 378 43 Greiner Greiner NNP 10_1101-2021_01_06_425584 378 44 , , , 10_1101-2021_01_06_425584 378 45 R. R. NNP 10_1101-2021_01_06_425584 378 46 ; ; : 10_1101-2021_01_06_425584 378 47 Wishart Wishart NNP 10_1101-2021_01_06_425584 378 48 , , , 10_1101-2021_01_06_425584 378 49 D. D. NNP 10_1101-2021_01_06_425584 378 50 S. S. NNP 10_1101-2021_01_06_425584 378 51 , , , 10_1101-2021_01_06_425584 378 52 ClassyFire ClassyFire NNP 10_1101-2021_01_06_425584 378 53 : : : 10_1101-2021_01_06_425584 378 54 624 624 CD 10_1101-2021_01_06_425584 378 55 automated automate VBD 10_1101-2021_01_06_425584 378 56 chemical chemical NN 10_1101-2021_01_06_425584 378 57 classification classification NN 10_1101-2021_01_06_425584 378 58 with with IN 10_1101-2021_01_06_425584 378 59 a a DT 10_1101-2021_01_06_425584 378 60 comprehensive comprehensive JJ 10_1101-2021_01_06_425584 378 61 , , , 10_1101-2021_01_06_425584 378 62 computable computable JJ 10_1101-2021_01_06_425584 378 63 taxonomy taxonomy NN 10_1101-2021_01_06_425584 378 64 . . . 10_1101-2021_01_06_425584 379 1 J J NNP 10_1101-2021_01_06_425584 379 2 Cheminform Cheminform NNP 10_1101-2021_01_06_425584 379 3 625 625 CD 10_1101-2021_01_06_425584 379 4 2016 2016 CD 10_1101-2021_01_06_425584 379 5 , , , 10_1101-2021_01_06_425584 379 6 8 8 CD 10_1101-2021_01_06_425584 379 7 , , , 10_1101-2021_01_06_425584 379 8 61 61 CD 10_1101-2021_01_06_425584 379 9 . . . 10_1101-2021_01_06_425584 380 1 626 626 CD 10_1101-2021_01_06_425584 380 2 28 28 CD 10_1101-2021_01_06_425584 380 3 . . . 10_1101-2021_01_06_425584 381 1 Schymanski Schymanski NNP 10_1101-2021_01_06_425584 381 2 , , , 10_1101-2021_01_06_425584 381 3 E. E. NNP 10_1101-2021_01_06_425584 381 4 L. L. NNP 10_1101-2021_01_06_425584 381 5 ; ; : 10_1101-2021_01_06_425584 381 6 Jeon Jeon NNP 10_1101-2021_01_06_425584 381 7 , , , 10_1101-2021_01_06_425584 381 8 J. J. NNP 10_1101-2021_01_06_425584 381 9 ; ; : 10_1101-2021_01_06_425584 381 10 Gulde Gulde NNP 10_1101-2021_01_06_425584 381 11 , , , 10_1101-2021_01_06_425584 381 12 R. R. NNP 10_1101-2021_01_06_425584 381 13 ; ; : 10_1101-2021_01_06_425584 381 14 Fenner Fenner NNP 10_1101-2021_01_06_425584 381 15 , , , 10_1101-2021_01_06_425584 381 16 K. K. NNP 10_1101-2021_01_06_425584 381 17 ; ; : 10_1101-2021_01_06_425584 381 18 Ruff Ruff NNP 10_1101-2021_01_06_425584 381 19 , , , 10_1101-2021_01_06_425584 381 20 M. M. NNP 10_1101-2021_01_06_425584 381 21 ; ; : 10_1101-2021_01_06_425584 381 22 Singer Singer NNP 10_1101-2021_01_06_425584 381 23 , , , 10_1101-2021_01_06_425584 381 24 H. H. NNP 10_1101-2021_01_06_425584 381 25 P. P. NNP 10_1101-2021_01_06_425584 381 26 ; ; : 10_1101-2021_01_06_425584 381 27 Hollender Hollender NNP 10_1101-2021_01_06_425584 381 28 , , , 10_1101-2021_01_06_425584 381 29 J. J. NNP 10_1101-2021_01_06_425584 381 30 , , , 10_1101-2021_01_06_425584 381 31 627 627 CD 10_1101-2021_01_06_425584 381 32 Identifying identify VBG 10_1101-2021_01_06_425584 381 33 small small JJ 10_1101-2021_01_06_425584 381 34 molecules molecule NNS 10_1101-2021_01_06_425584 381 35 via via IN 10_1101-2021_01_06_425584 381 36 high high JJ 10_1101-2021_01_06_425584 381 37 resolution resolution NN 10_1101-2021_01_06_425584 381 38 mass mass NN 10_1101-2021_01_06_425584 381 39 spectrometry spectrometry NN 10_1101-2021_01_06_425584 381 40 : : : 10_1101-2021_01_06_425584 381 41 communicating communicate VBG 10_1101-2021_01_06_425584 381 42 confidence confidence NN 10_1101-2021_01_06_425584 381 43 . . . 10_1101-2021_01_06_425584 382 1 628 628 CD 10_1101-2021_01_06_425584 382 2 Environ Environ NNP 10_1101-2021_01_06_425584 382 3 Sci Sci NNP 10_1101-2021_01_06_425584 382 4 Technol Technol NNP 10_1101-2021_01_06_425584 382 5 2014 2014 CD 10_1101-2021_01_06_425584 382 6 , , , 10_1101-2021_01_06_425584 382 7 48 48 CD 10_1101-2021_01_06_425584 382 8 , , , 10_1101-2021_01_06_425584 382 9 ( ( -LRB- 10_1101-2021_01_06_425584 382 10 4 4 CD 10_1101-2021_01_06_425584 382 11 ) ) -RRB- 10_1101-2021_01_06_425584 382 12 , , , 10_1101-2021_01_06_425584 382 13 2097 2097 CD 10_1101-2021_01_06_425584 382 14 - - SYM 10_1101-2021_01_06_425584 382 15 8 8 CD 10_1101-2021_01_06_425584 382 16 . . . 10_1101-2021_01_06_425584 383 1 629 629 CD 10_1101-2021_01_06_425584 383 2 .CC .CC : 10_1101-2021_01_06_425584 383 3 - - HYPH 10_1101-2021_01_06_425584 383 4 BY by IN 10_1101-2021_01_06_425584 383 5 - - HYPH 10_1101-2021_01_06_425584 383 6 NC NC NNP 10_1101-2021_01_06_425584 383 7 - - HYPH 10_1101-2021_01_06_425584 383 8 ND ND NNP 10_1101-2021_01_06_425584 383 9 4.0 4.0 CD 10_1101-2021_01_06_425584 383 10 International International NNP 10_1101-2021_01_06_425584 383 11 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 383 12 under under IN 10_1101-2021_01_06_425584 383 13 a a DT 10_1101-2021_01_06_425584 383 14 ( ( -LRB- 10_1101-2021_01_06_425584 383 15 which which WDT 10_1101-2021_01_06_425584 383 16 was be VBD 10_1101-2021_01_06_425584 383 17 not not RB 10_1101-2021_01_06_425584 383 18 certified certify VBN 10_1101-2021_01_06_425584 383 19 by by IN 10_1101-2021_01_06_425584 383 20 peer peer NN 10_1101-2021_01_06_425584 383 21 review review NN 10_1101-2021_01_06_425584 383 22 ) ) -RRB- 10_1101-2021_01_06_425584 383 23 is be VBZ 10_1101-2021_01_06_425584 383 24 the the DT 10_1101-2021_01_06_425584 383 25 author author NN 10_1101-2021_01_06_425584 383 26 / / SYM 10_1101-2021_01_06_425584 383 27 funder funder NN 10_1101-2021_01_06_425584 383 28 , , , 10_1101-2021_01_06_425584 383 29 who who WP 10_1101-2021_01_06_425584 383 30 has have VBZ 10_1101-2021_01_06_425584 383 31 granted grant VBN 10_1101-2021_01_06_425584 383 32 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 383 33 a a DT 10_1101-2021_01_06_425584 383 34 license license NN 10_1101-2021_01_06_425584 383 35 to to TO 10_1101-2021_01_06_425584 383 36 display display VB 10_1101-2021_01_06_425584 383 37 the the DT 10_1101-2021_01_06_425584 383 38 preprint preprint NN 10_1101-2021_01_06_425584 383 39 in in IN 10_1101-2021_01_06_425584 383 40 perpetuity perpetuity NN 10_1101-2021_01_06_425584 383 41 . . . 10_1101-2021_01_06_425584 384 1 It -PRON- PRP 10_1101-2021_01_06_425584 384 2 is be VBZ 10_1101-2021_01_06_425584 384 3 made make VBN 10_1101-2021_01_06_425584 384 4 The the DT 10_1101-2021_01_06_425584 384 5 copyright copyright NN 10_1101-2021_01_06_425584 384 6 holder holder NN 10_1101-2021_01_06_425584 384 7 for for IN 10_1101-2021_01_06_425584 384 8 this this DT 10_1101-2021_01_06_425584 384 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 384 10 version version NN 10_1101-2021_01_06_425584 384 11 posted post VBD 10_1101-2021_01_06_425584 384 12 January January NNP 10_1101-2021_01_06_425584 384 13 8 8 CD 10_1101-2021_01_06_425584 384 14 , , , 10_1101-2021_01_06_425584 384 15 2021 2021 CD 10_1101-2021_01_06_425584 384 16 . . . 10_1101-2021_01_06_425584 384 17 ; ; : 10_1101-2021_01_06_425584 384 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 384 19 : : : 10_1101-2021_01_06_425584 384 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 384 21 preprint preprint NN 10_1101-2021_01_06_425584 384 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 384 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 384 24 23 23 CD 10_1101-2021_01_06_425584 384 25 29 29 CD 10_1101-2021_01_06_425584 384 26 . . . 10_1101-2021_01_06_425584 385 1 Ernst Ernst NNP 10_1101-2021_01_06_425584 385 2 , , , 10_1101-2021_01_06_425584 385 3 M. M. NNP 10_1101-2021_01_06_425584 385 4 ; ; : 10_1101-2021_01_06_425584 385 5 Kang Kang NNP 10_1101-2021_01_06_425584 385 6 , , , 10_1101-2021_01_06_425584 385 7 K. K. NNP 10_1101-2021_01_06_425584 385 8 B. B. NNP 10_1101-2021_01_06_425584 385 9 ; ; : 10_1101-2021_01_06_425584 385 10 Caraballo Caraballo NNP 10_1101-2021_01_06_425584 385 11 - - HYPH 10_1101-2021_01_06_425584 385 12 Rodriguez Rodriguez NNP 10_1101-2021_01_06_425584 385 13 , , , 10_1101-2021_01_06_425584 385 14 A. a. NN 10_1101-2021_01_06_425584 385 15 M. M. NNP 10_1101-2021_01_06_425584 385 16 ; ; : 10_1101-2021_01_06_425584 385 17 Nothias Nothias NNP 10_1101-2021_01_06_425584 385 18 , , , 10_1101-2021_01_06_425584 385 19 L. L. NNP 10_1101-2021_01_06_425584 385 20 F. F. NNP 10_1101-2021_01_06_425584 385 21 ; ; : 10_1101-2021_01_06_425584 385 22 Wandy Wandy NNP 10_1101-2021_01_06_425584 385 23 , , , 10_1101-2021_01_06_425584 385 24 J. J. NNP 10_1101-2021_01_06_425584 385 25 ; ; : 10_1101-2021_01_06_425584 385 26 Chen Chen NNP 10_1101-2021_01_06_425584 385 27 , , , 10_1101-2021_01_06_425584 385 28 C. C. NNP 10_1101-2021_01_06_425584 385 29 ; ; : 10_1101-2021_01_06_425584 385 30 630 630 CD 10_1101-2021_01_06_425584 385 31 Wang Wang NNP 10_1101-2021_01_06_425584 385 32 , , , 10_1101-2021_01_06_425584 385 33 M. M. NNP 10_1101-2021_01_06_425584 385 34 ; ; : 10_1101-2021_01_06_425584 385 35 Rogers Rogers NNP 10_1101-2021_01_06_425584 385 36 , , , 10_1101-2021_01_06_425584 385 37 S. S. NNP 10_1101-2021_01_06_425584 385 38 ; ; : 10_1101-2021_01_06_425584 385 39 Medema Medema NNP 10_1101-2021_01_06_425584 385 40 , , , 10_1101-2021_01_06_425584 385 41 M. M. NNP 10_1101-2021_01_06_425584 385 42 H. H. NNP 10_1101-2021_01_06_425584 385 43 ; ; : 10_1101-2021_01_06_425584 385 44 Dorrestein Dorrestein NNP 10_1101-2021_01_06_425584 385 45 , , , 10_1101-2021_01_06_425584 385 46 P. P. NNP 10_1101-2021_01_06_425584 385 47 C. C. NNP 10_1101-2021_01_06_425584 385 48 ; ; : 10_1101-2021_01_06_425584 385 49 van van NNP 10_1101-2021_01_06_425584 385 50 der der NNP 10_1101-2021_01_06_425584 385 51 Hooft Hooft NNP 10_1101-2021_01_06_425584 385 52 , , , 10_1101-2021_01_06_425584 385 53 J. J. NNP 10_1101-2021_01_06_425584 385 54 J. J. NNP 10_1101-2021_01_06_425584 385 55 J. J. NNP 10_1101-2021_01_06_425584 385 56 , , , 10_1101-2021_01_06_425584 385 57 631 631 CD 10_1101-2021_01_06_425584 385 58 MolNetEnhancer molnetenhancer NN 10_1101-2021_01_06_425584 385 59 : : : 10_1101-2021_01_06_425584 385 60 Enhanced Enhanced NNP 10_1101-2021_01_06_425584 385 61 Molecular Molecular NNP 10_1101-2021_01_06_425584 385 62 Networks Networks NNP 10_1101-2021_01_06_425584 385 63 by by IN 10_1101-2021_01_06_425584 385 64 Integrating integrate VBG 10_1101-2021_01_06_425584 385 65 Metabolome Metabolome NNP 10_1101-2021_01_06_425584 385 66 Mining Mining NNP 10_1101-2021_01_06_425584 385 67 and and CC 10_1101-2021_01_06_425584 385 68 632 632 CD 10_1101-2021_01_06_425584 385 69 Annotation annotation NN 10_1101-2021_01_06_425584 385 70 Tools tool NNS 10_1101-2021_01_06_425584 385 71 . . . 10_1101-2021_01_06_425584 386 1 Metabolites metabolite NNS 10_1101-2021_01_06_425584 386 2 2019 2019 CD 10_1101-2021_01_06_425584 386 3 , , , 10_1101-2021_01_06_425584 386 4 9 9 CD 10_1101-2021_01_06_425584 386 5 , , , 10_1101-2021_01_06_425584 386 6 ( ( -LRB- 10_1101-2021_01_06_425584 386 7 7 7 CD 10_1101-2021_01_06_425584 386 8 ) ) -RRB- 10_1101-2021_01_06_425584 386 9 . . . 10_1101-2021_01_06_425584 387 1 633 633 CD 10_1101-2021_01_06_425584 387 2 30 30 CD 10_1101-2021_01_06_425584 387 3 . . . 10_1101-2021_01_06_425584 388 1 Shannon Shannon NNP 10_1101-2021_01_06_425584 388 2 , , , 10_1101-2021_01_06_425584 388 3 P. P. NNP 10_1101-2021_01_06_425584 388 4 ; ; : 10_1101-2021_01_06_425584 388 5 Markiel Markiel NNP 10_1101-2021_01_06_425584 388 6 , , , 10_1101-2021_01_06_425584 388 7 A. a. NN 10_1101-2021_01_06_425584 388 8 ; ; : 10_1101-2021_01_06_425584 388 9 Ozier Ozier NNP 10_1101-2021_01_06_425584 388 10 , , , 10_1101-2021_01_06_425584 388 11 O. O. NNP 10_1101-2021_01_06_425584 388 12 ; ; : 10_1101-2021_01_06_425584 388 13 Baliga Baliga NNP 10_1101-2021_01_06_425584 388 14 , , , 10_1101-2021_01_06_425584 388 15 N. N. NNP 10_1101-2021_01_06_425584 388 16 S. S. NNP 10_1101-2021_01_06_425584 388 17 ; ; : 10_1101-2021_01_06_425584 388 18 Wang Wang NNP 10_1101-2021_01_06_425584 388 19 , , , 10_1101-2021_01_06_425584 388 20 J. J. NNP 10_1101-2021_01_06_425584 388 21 T. T. NNP 10_1101-2021_01_06_425584 388 22 ; ; : 10_1101-2021_01_06_425584 388 23 Ramage Ramage NNP 10_1101-2021_01_06_425584 388 24 , , , 10_1101-2021_01_06_425584 388 25 D. D. NNP 10_1101-2021_01_06_425584 388 26 ; ; : 10_1101-2021_01_06_425584 388 27 Amin Amin NNP 10_1101-2021_01_06_425584 388 28 , , , 10_1101-2021_01_06_425584 388 29 N. N. NNP 10_1101-2021_01_06_425584 388 30 ; ; : 10_1101-2021_01_06_425584 388 31 634 634 CD 10_1101-2021_01_06_425584 388 32 Schwikowski Schwikowski NNP 10_1101-2021_01_06_425584 388 33 , , , 10_1101-2021_01_06_425584 388 34 B. B. NNP 10_1101-2021_01_06_425584 388 35 ; ; : 10_1101-2021_01_06_425584 388 36 Ideker Ideker NNP 10_1101-2021_01_06_425584 388 37 , , , 10_1101-2021_01_06_425584 388 38 T. T. NNP 10_1101-2021_01_06_425584 388 39 , , , 10_1101-2021_01_06_425584 388 40 Cytoscape Cytoscape NNP 10_1101-2021_01_06_425584 388 41 : : : 10_1101-2021_01_06_425584 388 42 a a DT 10_1101-2021_01_06_425584 388 43 software software NN 10_1101-2021_01_06_425584 388 44 environment environment NN 10_1101-2021_01_06_425584 388 45 for for IN 10_1101-2021_01_06_425584 388 46 integrated integrate VBN 10_1101-2021_01_06_425584 388 47 models model NNS 10_1101-2021_01_06_425584 388 48 of of IN 10_1101-2021_01_06_425584 388 49 635 635 CD 10_1101-2021_01_06_425584 388 50 biomolecular biomolecular JJ 10_1101-2021_01_06_425584 388 51 interaction interaction NN 10_1101-2021_01_06_425584 388 52 networks network NNS 10_1101-2021_01_06_425584 388 53 . . . 10_1101-2021_01_06_425584 389 1 Genome Genome NNP 10_1101-2021_01_06_425584 389 2 Res Res NNP 10_1101-2021_01_06_425584 389 3 2003 2003 CD 10_1101-2021_01_06_425584 389 4 , , , 10_1101-2021_01_06_425584 389 5 13 13 CD 10_1101-2021_01_06_425584 389 6 , , , 10_1101-2021_01_06_425584 389 7 ( ( -LRB- 10_1101-2021_01_06_425584 389 8 11 11 CD 10_1101-2021_01_06_425584 389 9 ) ) -RRB- 10_1101-2021_01_06_425584 389 10 , , , 10_1101-2021_01_06_425584 389 11 2498 2498 CD 10_1101-2021_01_06_425584 389 12 - - SYM 10_1101-2021_01_06_425584 389 13 504 504 CD 10_1101-2021_01_06_425584 389 14 . . . 10_1101-2021_01_06_425584 390 1 636 636 CD 10_1101-2021_01_06_425584 390 2 31 31 CD 10_1101-2021_01_06_425584 390 3 . . . 10_1101-2021_01_06_425584 391 1 Perez Perez NNP 10_1101-2021_01_06_425584 391 2 - - HYPH 10_1101-2021_01_06_425584 391 3 Riverol Riverol NNP 10_1101-2021_01_06_425584 391 4 , , , 10_1101-2021_01_06_425584 391 5 Y. Y. NNP 10_1101-2021_01_06_425584 391 6 ; ; : 10_1101-2021_01_06_425584 391 7 Csordas Csordas NNP 10_1101-2021_01_06_425584 391 8 , , , 10_1101-2021_01_06_425584 391 9 A. a. NN 10_1101-2021_01_06_425584 391 10 ; ; : 10_1101-2021_01_06_425584 391 11 Bai Bai NNP 10_1101-2021_01_06_425584 391 12 , , , 10_1101-2021_01_06_425584 391 13 J. J. NNP 10_1101-2021_01_06_425584 391 14 ; ; : 10_1101-2021_01_06_425584 391 15 Bernal Bernal NNP 10_1101-2021_01_06_425584 391 16 - - HYPH 10_1101-2021_01_06_425584 391 17 Llinares Llinares NNP 10_1101-2021_01_06_425584 391 18 , , , 10_1101-2021_01_06_425584 391 19 M. M. NNP 10_1101-2021_01_06_425584 391 20 ; ; : 10_1101-2021_01_06_425584 391 21 Hewapathirana Hewapathirana NNP 10_1101-2021_01_06_425584 391 22 , , , 10_1101-2021_01_06_425584 391 23 S. S. NNP 10_1101-2021_01_06_425584 391 24 ; ; : 10_1101-2021_01_06_425584 391 25 Kundu Kundu NNP 10_1101-2021_01_06_425584 391 26 , , , 10_1101-2021_01_06_425584 391 27 637 637 CD 10_1101-2021_01_06_425584 391 28 D. D. NNP 10_1101-2021_01_06_425584 391 29 J. J. NNP 10_1101-2021_01_06_425584 391 30 ; ; : 10_1101-2021_01_06_425584 391 31 Inuganti Inuganti NNP 10_1101-2021_01_06_425584 391 32 , , , 10_1101-2021_01_06_425584 391 33 A. a. NN 10_1101-2021_01_06_425584 391 34 ; ; : 10_1101-2021_01_06_425584 391 35 Griss Griss NNP 10_1101-2021_01_06_425584 391 36 , , , 10_1101-2021_01_06_425584 391 37 J. J. NNP 10_1101-2021_01_06_425584 391 38 ; ; : 10_1101-2021_01_06_425584 391 39 Mayer Mayer NNP 10_1101-2021_01_06_425584 391 40 , , , 10_1101-2021_01_06_425584 391 41 G. G. NNP 10_1101-2021_01_06_425584 391 42 ; ; : 10_1101-2021_01_06_425584 391 43 Eisenacher Eisenacher NNP 10_1101-2021_01_06_425584 391 44 , , , 10_1101-2021_01_06_425584 391 45 M. M. NNP 10_1101-2021_01_06_425584 391 46 ; ; : 10_1101-2021_01_06_425584 391 47 Perez Perez NNP 10_1101-2021_01_06_425584 391 48 , , , 10_1101-2021_01_06_425584 391 49 E. E. NNP 10_1101-2021_01_06_425584 391 50 ; ; : 10_1101-2021_01_06_425584 391 51 Uszkoreit Uszkoreit NNP 10_1101-2021_01_06_425584 391 52 , , , 10_1101-2021_01_06_425584 391 53 J. J. NNP 10_1101-2021_01_06_425584 391 54 ; ; : 10_1101-2021_01_06_425584 391 55 Pfeuffer Pfeuffer NNP 10_1101-2021_01_06_425584 391 56 , , , 10_1101-2021_01_06_425584 391 57 J. J. NNP 10_1101-2021_01_06_425584 391 58 ; ; : 10_1101-2021_01_06_425584 391 59 638 638 CD 10_1101-2021_01_06_425584 391 60 Sachsenberg Sachsenberg NNP 10_1101-2021_01_06_425584 391 61 , , , 10_1101-2021_01_06_425584 391 62 T. T. NNP 10_1101-2021_01_06_425584 391 63 ; ; : 10_1101-2021_01_06_425584 391 64 Yilmaz Yilmaz NNP 10_1101-2021_01_06_425584 391 65 , , , 10_1101-2021_01_06_425584 391 66 S. S. NNP 10_1101-2021_01_06_425584 391 67 ; ; : 10_1101-2021_01_06_425584 391 68 Tiwary Tiwary NNP 10_1101-2021_01_06_425584 391 69 , , , 10_1101-2021_01_06_425584 391 70 S. S. NNP 10_1101-2021_01_06_425584 391 71 ; ; : 10_1101-2021_01_06_425584 391 72 Cox Cox NNP 10_1101-2021_01_06_425584 391 73 , , , 10_1101-2021_01_06_425584 391 74 J. J. NNP 10_1101-2021_01_06_425584 391 75 ; ; : 10_1101-2021_01_06_425584 391 76 Audain Audain NNP 10_1101-2021_01_06_425584 391 77 , , , 10_1101-2021_01_06_425584 391 78 E. E. NNP 10_1101-2021_01_06_425584 391 79 ; ; : 10_1101-2021_01_06_425584 391 80 Walzer Walzer NNP 10_1101-2021_01_06_425584 391 81 , , , 10_1101-2021_01_06_425584 391 82 M. M. NNP 10_1101-2021_01_06_425584 391 83 ; ; : 10_1101-2021_01_06_425584 391 84 Jarnuczak Jarnuczak NNP 10_1101-2021_01_06_425584 391 85 , , , 10_1101-2021_01_06_425584 391 86 A. A. NNP 10_1101-2021_01_06_425584 391 87 F. F. NNP 10_1101-2021_01_06_425584 391 88 ; ; : 10_1101-2021_01_06_425584 391 89 639 639 CD 10_1101-2021_01_06_425584 391 90 Ternent ternent NN 10_1101-2021_01_06_425584 391 91 , , , 10_1101-2021_01_06_425584 391 92 T. t. NN 10_1101-2021_01_06_425584 391 93 ; ; : 10_1101-2021_01_06_425584 391 94 Brazma Brazma NNP 10_1101-2021_01_06_425584 391 95 , , , 10_1101-2021_01_06_425584 391 96 A. a. NN 10_1101-2021_01_06_425584 391 97 ; ; : 10_1101-2021_01_06_425584 391 98 Vizcaino Vizcaino NNP 10_1101-2021_01_06_425584 391 99 , , , 10_1101-2021_01_06_425584 391 100 J. J. NNP 10_1101-2021_01_06_425584 392 1 A. A. NNP 10_1101-2021_01_06_425584 392 2 , , , 10_1101-2021_01_06_425584 392 3 The the DT 10_1101-2021_01_06_425584 392 4 PRIDE PRIDE NNP 10_1101-2021_01_06_425584 392 5 database database NN 10_1101-2021_01_06_425584 392 6 and and CC 10_1101-2021_01_06_425584 392 7 related related JJ 10_1101-2021_01_06_425584 392 8 tools tool NNS 10_1101-2021_01_06_425584 392 9 and and CC 10_1101-2021_01_06_425584 392 10 resources resource NNS 10_1101-2021_01_06_425584 392 11 640 640 CD 10_1101-2021_01_06_425584 392 12 in in IN 10_1101-2021_01_06_425584 392 13 2019 2019 CD 10_1101-2021_01_06_425584 392 14 : : : 10_1101-2021_01_06_425584 392 15 improving improve VBG 10_1101-2021_01_06_425584 392 16 support support NN 10_1101-2021_01_06_425584 392 17 for for IN 10_1101-2021_01_06_425584 392 18 quantification quantification NN 10_1101-2021_01_06_425584 392 19 data datum NNS 10_1101-2021_01_06_425584 392 20 . . . 10_1101-2021_01_06_425584 393 1 Nucleic Nucleic NNP 10_1101-2021_01_06_425584 393 2 Acids Acids NNPS 10_1101-2021_01_06_425584 393 3 Res Res NNP 10_1101-2021_01_06_425584 393 4 2019 2019 CD 10_1101-2021_01_06_425584 393 5 , , , 10_1101-2021_01_06_425584 393 6 47 47 CD 10_1101-2021_01_06_425584 393 7 , , , 10_1101-2021_01_06_425584 393 8 ( ( -LRB- 10_1101-2021_01_06_425584 393 9 D1 d1 NN 10_1101-2021_01_06_425584 393 10 ) ) -RRB- 10_1101-2021_01_06_425584 393 11 , , , 10_1101-2021_01_06_425584 393 12 D442 D442 NNPS 10_1101-2021_01_06_425584 393 13 - - HYPH 10_1101-2021_01_06_425584 393 14 641 641 CD 10_1101-2021_01_06_425584 393 15 D450 D450 NNP 10_1101-2021_01_06_425584 393 16 . . . 10_1101-2021_01_06_425584 394 1 642 642 CD 10_1101-2021_01_06_425584 394 2 32 32 CD 10_1101-2021_01_06_425584 394 3 . . . 10_1101-2021_01_06_425584 395 1 Willforss Willforss NNP 10_1101-2021_01_06_425584 395 2 , , , 10_1101-2021_01_06_425584 395 3 J. J. NNP 10_1101-2021_01_06_425584 395 4 ; ; : 10_1101-2021_01_06_425584 395 5 Chawade Chawade NNP 10_1101-2021_01_06_425584 395 6 , , , 10_1101-2021_01_06_425584 395 7 A. a. NN 10_1101-2021_01_06_425584 395 8 ; ; : 10_1101-2021_01_06_425584 395 9 Levander Levander NNP 10_1101-2021_01_06_425584 395 10 , , , 10_1101-2021_01_06_425584 395 11 F. F. NNP 10_1101-2021_01_06_425584 395 12 , , , 10_1101-2021_01_06_425584 395 13 NormalyzerDE NormalyzerDE NNP 10_1101-2021_01_06_425584 395 14 : : : 10_1101-2021_01_06_425584 395 15 Online Online NNP 10_1101-2021_01_06_425584 395 16 Tool Tool NNP 10_1101-2021_01_06_425584 395 17 for for IN 10_1101-2021_01_06_425584 395 18 Improved Improved NNP 10_1101-2021_01_06_425584 395 19 643 643 CD 10_1101-2021_01_06_425584 395 20 Normalization Normalization NNP 10_1101-2021_01_06_425584 395 21 of of IN 10_1101-2021_01_06_425584 395 22 Omics Omics NNP 10_1101-2021_01_06_425584 395 23 Expression Expression NNP 10_1101-2021_01_06_425584 395 24 Data Data NNP 10_1101-2021_01_06_425584 395 25 and and CC 10_1101-2021_01_06_425584 395 26 High High NNP 10_1101-2021_01_06_425584 395 27 - - HYPH 10_1101-2021_01_06_425584 395 28 Sensitivity Sensitivity NNP 10_1101-2021_01_06_425584 395 29 Differential Differential NNP 10_1101-2021_01_06_425584 395 30 Expression Expression NNP 10_1101-2021_01_06_425584 395 31 Analysis Analysis NNP 10_1101-2021_01_06_425584 395 32 . . . 10_1101-2021_01_06_425584 396 1 J J NNP 10_1101-2021_01_06_425584 396 2 644 644 CD 10_1101-2021_01_06_425584 396 3 Proteome Proteome NNP 10_1101-2021_01_06_425584 396 4 Res Res NNP 10_1101-2021_01_06_425584 396 5 2019 2019 CD 10_1101-2021_01_06_425584 396 6 , , , 10_1101-2021_01_06_425584 396 7 18 18 CD 10_1101-2021_01_06_425584 396 8 , , , 10_1101-2021_01_06_425584 396 9 ( ( -LRB- 10_1101-2021_01_06_425584 396 10 2 2 CD 10_1101-2021_01_06_425584 396 11 ) ) -RRB- 10_1101-2021_01_06_425584 396 12 , , , 10_1101-2021_01_06_425584 396 13 732 732 CD 10_1101-2021_01_06_425584 396 14 - - SYM 10_1101-2021_01_06_425584 396 15 740 740 CD 10_1101-2021_01_06_425584 396 16 . . . 10_1101-2021_01_06_425584 397 1 645 645 CD 10_1101-2021_01_06_425584 397 2 33 33 CD 10_1101-2021_01_06_425584 397 3 . . . 10_1101-2021_01_06_425584 398 1 Zhou Zhou NNP 10_1101-2021_01_06_425584 398 2 , , , 10_1101-2021_01_06_425584 398 3 G. G. NNP 10_1101-2021_01_06_425584 398 4 ; ; : 10_1101-2021_01_06_425584 398 5 Xia Xia NNP 10_1101-2021_01_06_425584 398 6 , , , 10_1101-2021_01_06_425584 398 7 J. J. NNP 10_1101-2021_01_06_425584 398 8 , , , 10_1101-2021_01_06_425584 398 9 Using use VBG 10_1101-2021_01_06_425584 398 10 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 398 11 for for IN 10_1101-2021_01_06_425584 398 12 Network Network NNP 10_1101-2021_01_06_425584 398 13 Integration Integration NNP 10_1101-2021_01_06_425584 398 14 and and CC 10_1101-2021_01_06_425584 398 15 3D 3d JJ 10_1101-2021_01_06_425584 398 16 Visualization visualization NN 10_1101-2021_01_06_425584 398 17 . . . 10_1101-2021_01_06_425584 399 1 Curr Curr NNP 10_1101-2021_01_06_425584 399 2 646 646 CD 10_1101-2021_01_06_425584 399 3 Protoc Protoc NNP 10_1101-2021_01_06_425584 399 4 Bioinformatics Bioinformatics NNPS 10_1101-2021_01_06_425584 399 5 2019 2019 CD 10_1101-2021_01_06_425584 399 6 , , , 10_1101-2021_01_06_425584 399 7 65 65 CD 10_1101-2021_01_06_425584 399 8 , , , 10_1101-2021_01_06_425584 399 9 ( ( -LRB- 10_1101-2021_01_06_425584 399 10 1 1 CD 10_1101-2021_01_06_425584 399 11 ) ) -RRB- 10_1101-2021_01_06_425584 399 12 , , , 10_1101-2021_01_06_425584 399 13 e69 e69 CD 10_1101-2021_01_06_425584 399 14 . . . 10_1101-2021_01_06_425584 400 1 647 647 CD 10_1101-2021_01_06_425584 400 2 34 34 CD 10_1101-2021_01_06_425584 400 3 . . . 10_1101-2021_01_06_425584 401 1 Zhou Zhou NNP 10_1101-2021_01_06_425584 401 2 , , , 10_1101-2021_01_06_425584 401 3 G. G. NNP 10_1101-2021_01_06_425584 401 4 ; ; : 10_1101-2021_01_06_425584 401 5 Xia Xia NNP 10_1101-2021_01_06_425584 401 6 , , , 10_1101-2021_01_06_425584 401 7 J. J. NNP 10_1101-2021_01_06_425584 401 8 , , , 10_1101-2021_01_06_425584 401 9 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 401 10 : : : 10_1101-2021_01_06_425584 401 11 a a DT 10_1101-2021_01_06_425584 401 12 web web NN 10_1101-2021_01_06_425584 401 13 - - HYPH 10_1101-2021_01_06_425584 401 14 based base VBN 10_1101-2021_01_06_425584 401 15 tool tool NN 10_1101-2021_01_06_425584 401 16 for for IN 10_1101-2021_01_06_425584 401 17 creation creation NN 10_1101-2021_01_06_425584 401 18 and and CC 10_1101-2021_01_06_425584 401 19 visual visual JJ 10_1101-2021_01_06_425584 401 20 analysis analysis NN 10_1101-2021_01_06_425584 401 21 of of IN 10_1101-2021_01_06_425584 401 22 648 648 CD 10_1101-2021_01_06_425584 401 23 biological biological JJ 10_1101-2021_01_06_425584 401 24 networks network NNS 10_1101-2021_01_06_425584 401 25 in in IN 10_1101-2021_01_06_425584 401 26 3D 3D NNP 10_1101-2021_01_06_425584 401 27 space space NN 10_1101-2021_01_06_425584 401 28 . . . 10_1101-2021_01_06_425584 402 1 Nucleic Nucleic NNP 10_1101-2021_01_06_425584 402 2 Acids Acids NNPS 10_1101-2021_01_06_425584 402 3 Res Res NNP 10_1101-2021_01_06_425584 402 4 2018 2018 CD 10_1101-2021_01_06_425584 402 5 , , , 10_1101-2021_01_06_425584 402 6 46 46 CD 10_1101-2021_01_06_425584 402 7 , , , 10_1101-2021_01_06_425584 402 8 ( ( -LRB- 10_1101-2021_01_06_425584 402 9 W1 W1 NNP 10_1101-2021_01_06_425584 402 10 ) ) -RRB- 10_1101-2021_01_06_425584 402 11 , , , 10_1101-2021_01_06_425584 402 12 W514-W522 W514-W522 NNP 10_1101-2021_01_06_425584 402 13 . . . 10_1101-2021_01_06_425584 403 1 649 649 CD 10_1101-2021_01_06_425584 403 2 35 35 CD 10_1101-2021_01_06_425584 403 3 . . . 10_1101-2021_01_06_425584 404 1 Szklarczyk Szklarczyk NNP 10_1101-2021_01_06_425584 404 2 , , , 10_1101-2021_01_06_425584 404 3 D. D. NNP 10_1101-2021_01_06_425584 404 4 ; ; : 10_1101-2021_01_06_425584 404 5 Franceschini Franceschini NNP 10_1101-2021_01_06_425584 404 6 , , , 10_1101-2021_01_06_425584 404 7 A. a. NN 10_1101-2021_01_06_425584 404 8 ; ; : 10_1101-2021_01_06_425584 404 9 Wyder Wyder NNP 10_1101-2021_01_06_425584 404 10 , , , 10_1101-2021_01_06_425584 404 11 S. S. NNP 10_1101-2021_01_06_425584 404 12 ; ; : 10_1101-2021_01_06_425584 404 13 Forslund Forslund NNP 10_1101-2021_01_06_425584 404 14 , , , 10_1101-2021_01_06_425584 404 15 K. K. NNP 10_1101-2021_01_06_425584 404 16 ; ; : 10_1101-2021_01_06_425584 404 17 Heller Heller NNP 10_1101-2021_01_06_425584 404 18 , , , 10_1101-2021_01_06_425584 404 19 D. D. NNP 10_1101-2021_01_06_425584 404 20 ; ; : 10_1101-2021_01_06_425584 404 21 Huerta Huerta NNP 10_1101-2021_01_06_425584 404 22 - - HYPH 10_1101-2021_01_06_425584 404 23 Cepas Cepas NNP 10_1101-2021_01_06_425584 404 24 , , , 10_1101-2021_01_06_425584 404 25 J. J. NNP 10_1101-2021_01_06_425584 404 26 ; ; : 10_1101-2021_01_06_425584 404 27 650 650 CD 10_1101-2021_01_06_425584 404 28 Simonovic Simonovic NNP 10_1101-2021_01_06_425584 404 29 , , , 10_1101-2021_01_06_425584 404 30 M. M. NNP 10_1101-2021_01_06_425584 404 31 ; ; : 10_1101-2021_01_06_425584 404 32 Roth Roth NNP 10_1101-2021_01_06_425584 404 33 , , , 10_1101-2021_01_06_425584 404 34 A. a. NN 10_1101-2021_01_06_425584 404 35 ; ; : 10_1101-2021_01_06_425584 404 36 Santos Santos NNP 10_1101-2021_01_06_425584 404 37 , , , 10_1101-2021_01_06_425584 404 38 A. a. NN 10_1101-2021_01_06_425584 404 39 ; ; : 10_1101-2021_01_06_425584 404 40 Tsafou Tsafou NNP 10_1101-2021_01_06_425584 404 41 , , , 10_1101-2021_01_06_425584 404 42 K. K. NNP 10_1101-2021_01_06_425584 404 43 P. P. NNP 10_1101-2021_01_06_425584 404 44 ; ; : 10_1101-2021_01_06_425584 404 45 Kuhn Kuhn NNP 10_1101-2021_01_06_425584 404 46 , , , 10_1101-2021_01_06_425584 404 47 M. M. NNP 10_1101-2021_01_06_425584 404 48 ; ; : 10_1101-2021_01_06_425584 404 49 Bork Bork NNP 10_1101-2021_01_06_425584 404 50 , , , 10_1101-2021_01_06_425584 404 51 P. P. NNP 10_1101-2021_01_06_425584 404 52 ; ; : 10_1101-2021_01_06_425584 404 53 Jensen Jensen NNP 10_1101-2021_01_06_425584 404 54 , , , 10_1101-2021_01_06_425584 404 55 L. L. NNP 10_1101-2021_01_06_425584 404 56 J. J. NNP 10_1101-2021_01_06_425584 404 57 ; ; : 10_1101-2021_01_06_425584 404 58 von von NNP 10_1101-2021_01_06_425584 404 59 651 651 CD 10_1101-2021_01_06_425584 404 60 Mering Mering NNP 10_1101-2021_01_06_425584 404 61 , , , 10_1101-2021_01_06_425584 404 62 C. C. NNP 10_1101-2021_01_06_425584 404 63 , , , 10_1101-2021_01_06_425584 404 64 STRING STRING NNP 10_1101-2021_01_06_425584 404 65 v10 v10 NN 10_1101-2021_01_06_425584 404 66 : : : 10_1101-2021_01_06_425584 404 67 protein protein NN 10_1101-2021_01_06_425584 404 68 - - HYPH 10_1101-2021_01_06_425584 404 69 protein protein NN 10_1101-2021_01_06_425584 404 70 interaction interaction NN 10_1101-2021_01_06_425584 404 71 networks network NNS 10_1101-2021_01_06_425584 404 72 , , , 10_1101-2021_01_06_425584 404 73 integrated integrate VBN 10_1101-2021_01_06_425584 404 74 over over IN 10_1101-2021_01_06_425584 404 75 the the DT 10_1101-2021_01_06_425584 404 76 tree tree NN 10_1101-2021_01_06_425584 404 77 of of IN 10_1101-2021_01_06_425584 404 78 life life NN 10_1101-2021_01_06_425584 404 79 . . . 10_1101-2021_01_06_425584 405 1 652 652 CD 10_1101-2021_01_06_425584 405 2 Nucleic Nucleic NNP 10_1101-2021_01_06_425584 405 3 Acids Acids NNPS 10_1101-2021_01_06_425584 405 4 Res Res NNP 10_1101-2021_01_06_425584 405 5 2015 2015 CD 10_1101-2021_01_06_425584 405 6 , , , 10_1101-2021_01_06_425584 405 7 43 43 CD 10_1101-2021_01_06_425584 405 8 , , , 10_1101-2021_01_06_425584 405 9 ( ( -LRB- 10_1101-2021_01_06_425584 405 10 Database Database NNP 10_1101-2021_01_06_425584 405 11 issue issue NN 10_1101-2021_01_06_425584 405 12 ) ) -RRB- 10_1101-2021_01_06_425584 405 13 , , , 10_1101-2021_01_06_425584 405 14 D447 D447 NNP 10_1101-2021_01_06_425584 405 15 - - HYPH 10_1101-2021_01_06_425584 405 16 52 52 CD 10_1101-2021_01_06_425584 405 17 . . . 10_1101-2021_01_06_425584 406 1 653 653 CD 10_1101-2021_01_06_425584 406 2 36 36 CD 10_1101-2021_01_06_425584 406 3 . . . 10_1101-2021_01_06_425584 407 1 Muntel Muntel NNP 10_1101-2021_01_06_425584 407 2 , , , 10_1101-2021_01_06_425584 407 3 J. J. NNP 10_1101-2021_01_06_425584 407 4 ; ; : 10_1101-2021_01_06_425584 407 5 Kirkpatrick Kirkpatrick NNP 10_1101-2021_01_06_425584 407 6 , , , 10_1101-2021_01_06_425584 407 7 J. J. NNP 10_1101-2021_01_06_425584 407 8 ; ; : 10_1101-2021_01_06_425584 407 9 Bruderer Bruderer NNP 10_1101-2021_01_06_425584 407 10 , , , 10_1101-2021_01_06_425584 407 11 R. R. NNP 10_1101-2021_01_06_425584 407 12 ; ; : 10_1101-2021_01_06_425584 407 13 Huang Huang NNP 10_1101-2021_01_06_425584 407 14 , , , 10_1101-2021_01_06_425584 407 15 T. T. NNP 10_1101-2021_01_06_425584 407 16 ; ; : 10_1101-2021_01_06_425584 407 17 Vitek Vitek NNP 10_1101-2021_01_06_425584 407 18 , , , 10_1101-2021_01_06_425584 407 19 O. O. NNP 10_1101-2021_01_06_425584 407 20 ; ; : 10_1101-2021_01_06_425584 407 21 Ori Ori NNP 10_1101-2021_01_06_425584 407 22 , , , 10_1101-2021_01_06_425584 407 23 A. A. NNP 10_1101-2021_01_06_425584 407 24 ; ; : 10_1101-2021_01_06_425584 407 25 Reiter Reiter NNP 10_1101-2021_01_06_425584 407 26 , , , 10_1101-2021_01_06_425584 407 27 L. L. NNP 10_1101-2021_01_06_425584 407 28 , , , 10_1101-2021_01_06_425584 407 29 654 654 CD 10_1101-2021_01_06_425584 407 30 Comparison Comparison NNP 10_1101-2021_01_06_425584 407 31 of of IN 10_1101-2021_01_06_425584 407 32 Protein Protein NNP 10_1101-2021_01_06_425584 407 33 Quantification Quantification NNP 10_1101-2021_01_06_425584 407 34 in in IN 10_1101-2021_01_06_425584 407 35 a a DT 10_1101-2021_01_06_425584 407 36 Complex Complex NNP 10_1101-2021_01_06_425584 407 37 Background Background NNP 10_1101-2021_01_06_425584 407 38 by by IN 10_1101-2021_01_06_425584 407 39 DIA DIA NNP 10_1101-2021_01_06_425584 407 40 and and CC 10_1101-2021_01_06_425584 407 41 TMT TMT NNP 10_1101-2021_01_06_425584 407 42 Workflows Workflows NNPS 10_1101-2021_01_06_425584 407 43 655 655 CD 10_1101-2021_01_06_425584 407 44 with with IN 10_1101-2021_01_06_425584 407 45 Fixed fix VBN 10_1101-2021_01_06_425584 407 46 Instrument Instrument NNP 10_1101-2021_01_06_425584 407 47 Time Time NNP 10_1101-2021_01_06_425584 407 48 . . . 10_1101-2021_01_06_425584 408 1 J J NNP 10_1101-2021_01_06_425584 408 2 Proteome Proteome NNP 10_1101-2021_01_06_425584 408 3 Res Res NNP 10_1101-2021_01_06_425584 408 4 2019 2019 CD 10_1101-2021_01_06_425584 408 5 , , , 10_1101-2021_01_06_425584 408 6 18 18 CD 10_1101-2021_01_06_425584 408 7 , , , 10_1101-2021_01_06_425584 408 8 ( ( -LRB- 10_1101-2021_01_06_425584 408 9 3 3 CD 10_1101-2021_01_06_425584 408 10 ) ) -RRB- 10_1101-2021_01_06_425584 408 11 , , , 10_1101-2021_01_06_425584 408 12 1340 1340 CD 10_1101-2021_01_06_425584 408 13 - - SYM 10_1101-2021_01_06_425584 408 14 1351 1351 CD 10_1101-2021_01_06_425584 408 15 . . . 10_1101-2021_01_06_425584 409 1 656 656 CD 10_1101-2021_01_06_425584 409 2 37 37 CD 10_1101-2021_01_06_425584 409 3 . . . 10_1101-2021_01_06_425584 410 1 Pascovici Pascovici NNP 10_1101-2021_01_06_425584 410 2 , , , 10_1101-2021_01_06_425584 410 3 D. D. NNP 10_1101-2021_01_06_425584 410 4 ; ; : 10_1101-2021_01_06_425584 410 5 Handler Handler NNP 10_1101-2021_01_06_425584 410 6 , , , 10_1101-2021_01_06_425584 410 7 D. D. NNP 10_1101-2021_01_06_425584 410 8 C. C. NNP 10_1101-2021_01_06_425584 410 9 ; ; : 10_1101-2021_01_06_425584 410 10 Wu Wu NNP 10_1101-2021_01_06_425584 410 11 , , , 10_1101-2021_01_06_425584 410 12 J. J. NNP 10_1101-2021_01_06_425584 410 13 X. X. NNP 10_1101-2021_01_06_425584 410 14 ; ; : 10_1101-2021_01_06_425584 410 15 Haynes Haynes NNP 10_1101-2021_01_06_425584 410 16 , , , 10_1101-2021_01_06_425584 410 17 P. P. NNP 10_1101-2021_01_06_425584 410 18 A. A. NNP 10_1101-2021_01_06_425584 410 19 , , , 10_1101-2021_01_06_425584 410 20 Multiple multiple JJ 10_1101-2021_01_06_425584 410 21 testing testing NN 10_1101-2021_01_06_425584 410 22 corrections correction NNS 10_1101-2021_01_06_425584 410 23 in in IN 10_1101-2021_01_06_425584 410 24 657 657 CD 10_1101-2021_01_06_425584 410 25 quantitative quantitative JJ 10_1101-2021_01_06_425584 410 26 proteomics proteomic NNS 10_1101-2021_01_06_425584 410 27 : : : 10_1101-2021_01_06_425584 410 28 A a DT 10_1101-2021_01_06_425584 410 29 useful useful JJ 10_1101-2021_01_06_425584 410 30 but but CC 10_1101-2021_01_06_425584 410 31 blunt blunt JJ 10_1101-2021_01_06_425584 410 32 tool tool NN 10_1101-2021_01_06_425584 410 33 . . . 10_1101-2021_01_06_425584 411 1 Proteomics proteomic NNS 10_1101-2021_01_06_425584 411 2 2016 2016 CD 10_1101-2021_01_06_425584 411 3 , , , 10_1101-2021_01_06_425584 411 4 16 16 CD 10_1101-2021_01_06_425584 411 5 , , , 10_1101-2021_01_06_425584 411 6 ( ( -LRB- 10_1101-2021_01_06_425584 411 7 18 18 CD 10_1101-2021_01_06_425584 411 8 ) ) -RRB- 10_1101-2021_01_06_425584 411 9 , , , 10_1101-2021_01_06_425584 411 10 2448 2448 CD 10_1101-2021_01_06_425584 411 11 - - SYM 10_1101-2021_01_06_425584 411 12 53 53 CD 10_1101-2021_01_06_425584 411 13 . . . 10_1101-2021_01_06_425584 412 1 658 658 CD 10_1101-2021_01_06_425584 412 2 38 38 CD 10_1101-2021_01_06_425584 412 3 . . . 10_1101-2021_01_06_425584 413 1 Wang Wang NNP 10_1101-2021_01_06_425584 413 2 , , , 10_1101-2021_01_06_425584 413 3 M. M. NNP 10_1101-2021_01_06_425584 413 4 ; ; : 10_1101-2021_01_06_425584 413 5 Carver Carver NNP 10_1101-2021_01_06_425584 413 6 , , , 10_1101-2021_01_06_425584 413 7 J. J. NNP 10_1101-2021_01_06_425584 413 8 J. J. NNP 10_1101-2021_01_06_425584 413 9 ; ; : 10_1101-2021_01_06_425584 413 10 Phelan Phelan NNP 10_1101-2021_01_06_425584 413 11 , , , 10_1101-2021_01_06_425584 413 12 V. V. NNP 10_1101-2021_01_06_425584 413 13 V. V. NNP 10_1101-2021_01_06_425584 413 14 ; ; : 10_1101-2021_01_06_425584 413 15 Sanchez Sanchez NNP 10_1101-2021_01_06_425584 413 16 , , , 10_1101-2021_01_06_425584 413 17 L. L. NNP 10_1101-2021_01_06_425584 413 18 M. M. NNP 10_1101-2021_01_06_425584 413 19 ; ; : 10_1101-2021_01_06_425584 413 20 Garg Garg NNP 10_1101-2021_01_06_425584 413 21 , , , 10_1101-2021_01_06_425584 413 22 N. N. NNP 10_1101-2021_01_06_425584 413 23 ; ; : 10_1101-2021_01_06_425584 413 24 Peng Peng NNP 10_1101-2021_01_06_425584 413 25 , , , 10_1101-2021_01_06_425584 413 26 Y. Y. NNP 10_1101-2021_01_06_425584 413 27 ; ; : 10_1101-2021_01_06_425584 413 28 Nguyen Nguyen NNP 10_1101-2021_01_06_425584 413 29 , , , 10_1101-2021_01_06_425584 413 30 D. D. NNP 10_1101-2021_01_06_425584 413 31 659 659 CD 10_1101-2021_01_06_425584 413 32 D. D. NNP 10_1101-2021_01_06_425584 413 33 ; ; : 10_1101-2021_01_06_425584 413 34 Watrous watrous JJ 10_1101-2021_01_06_425584 413 35 , , , 10_1101-2021_01_06_425584 413 36 J. J. NNP 10_1101-2021_01_06_425584 413 37 ; ; : 10_1101-2021_01_06_425584 413 38 Kapono Kapono NNP 10_1101-2021_01_06_425584 413 39 , , , 10_1101-2021_01_06_425584 413 40 C. C. NNP 10_1101-2021_01_06_425584 413 41 A. A. NNP 10_1101-2021_01_06_425584 413 42 ; ; : 10_1101-2021_01_06_425584 413 43 Luzzatto Luzzatto NNP 10_1101-2021_01_06_425584 413 44 - - HYPH 10_1101-2021_01_06_425584 413 45 Knaan Knaan NNP 10_1101-2021_01_06_425584 413 46 , , , 10_1101-2021_01_06_425584 413 47 T. T. NNP 10_1101-2021_01_06_425584 413 48 ; ; : 10_1101-2021_01_06_425584 413 49 Porto Porto NNP 10_1101-2021_01_06_425584 413 50 , , , 10_1101-2021_01_06_425584 413 51 C. C. NNP 10_1101-2021_01_06_425584 413 52 ; ; : 10_1101-2021_01_06_425584 413 53 Bouslimani Bouslimani NNP 10_1101-2021_01_06_425584 413 54 , , , 10_1101-2021_01_06_425584 413 55 A. a. NN 10_1101-2021_01_06_425584 413 56 ; ; : 10_1101-2021_01_06_425584 413 57 Melnik Melnik NNP 10_1101-2021_01_06_425584 413 58 , , , 10_1101-2021_01_06_425584 413 59 A. a. NN 10_1101-2021_01_06_425584 413 60 V. v. NN 10_1101-2021_01_06_425584 413 61 ; ; : 10_1101-2021_01_06_425584 413 62 660 660 CD 10_1101-2021_01_06_425584 413 63 Meehan Meehan NNP 10_1101-2021_01_06_425584 413 64 , , , 10_1101-2021_01_06_425584 413 65 M. M. NNP 10_1101-2021_01_06_425584 413 66 J. J. NNP 10_1101-2021_01_06_425584 413 67 ; ; : 10_1101-2021_01_06_425584 413 68 Liu Liu NNP 10_1101-2021_01_06_425584 413 69 , , , 10_1101-2021_01_06_425584 413 70 W. W. NNP 10_1101-2021_01_06_425584 413 71 T. T. NNP 10_1101-2021_01_06_425584 413 72 ; ; : 10_1101-2021_01_06_425584 413 73 Crusemann Crusemann NNP 10_1101-2021_01_06_425584 413 74 , , , 10_1101-2021_01_06_425584 413 75 M. M. NNP 10_1101-2021_01_06_425584 413 76 ; ; : 10_1101-2021_01_06_425584 413 77 Boudreau Boudreau NNP 10_1101-2021_01_06_425584 413 78 , , , 10_1101-2021_01_06_425584 413 79 P. P. NNP 10_1101-2021_01_06_425584 413 80 D. D. NNP 10_1101-2021_01_06_425584 413 81 ; ; : 10_1101-2021_01_06_425584 413 82 Esquenazi Esquenazi NNP 10_1101-2021_01_06_425584 413 83 , , , 10_1101-2021_01_06_425584 413 84 E. E. NNP 10_1101-2021_01_06_425584 413 85 ; ; : 10_1101-2021_01_06_425584 413 86 Sandoval Sandoval NNP 10_1101-2021_01_06_425584 413 87 - - HYPH 10_1101-2021_01_06_425584 413 88 Calderon Calderon NNP 10_1101-2021_01_06_425584 413 89 , , , 10_1101-2021_01_06_425584 413 90 661 661 CD 10_1101-2021_01_06_425584 413 91 M. M. NNP 10_1101-2021_01_06_425584 413 92 ; ; : 10_1101-2021_01_06_425584 413 93 Kersten Kersten NNP 10_1101-2021_01_06_425584 413 94 , , , 10_1101-2021_01_06_425584 413 95 R. R. NNP 10_1101-2021_01_06_425584 413 96 D. D. NNP 10_1101-2021_01_06_425584 413 97 ; ; : 10_1101-2021_01_06_425584 413 98 Pace Pace NNP 10_1101-2021_01_06_425584 413 99 , , , 10_1101-2021_01_06_425584 413 100 L. L. NNP 10_1101-2021_01_06_425584 413 101 A. a. NN 10_1101-2021_01_06_425584 413 102 ; ; : 10_1101-2021_01_06_425584 413 103 Quinn Quinn NNP 10_1101-2021_01_06_425584 413 104 , , , 10_1101-2021_01_06_425584 413 105 R. R. NNP 10_1101-2021_01_06_425584 413 106 A. a. NN 10_1101-2021_01_06_425584 413 107 ; ; : 10_1101-2021_01_06_425584 413 108 Duncan Duncan NNP 10_1101-2021_01_06_425584 413 109 , , , 10_1101-2021_01_06_425584 413 110 K. K. NNP 10_1101-2021_01_06_425584 413 111 R. R. NNP 10_1101-2021_01_06_425584 413 112 ; ; : 10_1101-2021_01_06_425584 413 113 Hsu Hsu NNP 10_1101-2021_01_06_425584 413 114 , , , 10_1101-2021_01_06_425584 413 115 C. C. NNP 10_1101-2021_01_06_425584 413 116 C. C. NNP 10_1101-2021_01_06_425584 413 117 ; ; : 10_1101-2021_01_06_425584 413 118 Floros Floros NNP 10_1101-2021_01_06_425584 413 119 , , , 10_1101-2021_01_06_425584 413 120 D. D. NNP 10_1101-2021_01_06_425584 413 121 J. J. NNP 10_1101-2021_01_06_425584 413 122 ; ; : 10_1101-2021_01_06_425584 413 123 Gavilan Gavilan NNP 10_1101-2021_01_06_425584 413 124 , , , 10_1101-2021_01_06_425584 413 125 662 662 CD 10_1101-2021_01_06_425584 413 126 R. R. NNP 10_1101-2021_01_06_425584 413 127 G. G. NNP 10_1101-2021_01_06_425584 413 128 ; ; : 10_1101-2021_01_06_425584 413 129 Kleigrewe Kleigrewe NNP 10_1101-2021_01_06_425584 413 130 , , , 10_1101-2021_01_06_425584 413 131 K. K. NNP 10_1101-2021_01_06_425584 413 132 ; ; : 10_1101-2021_01_06_425584 413 133 Northen Northen NNP 10_1101-2021_01_06_425584 413 134 , , , 10_1101-2021_01_06_425584 413 135 T. T. NNP 10_1101-2021_01_06_425584 413 136 ; ; : 10_1101-2021_01_06_425584 413 137 Dutton Dutton NNP 10_1101-2021_01_06_425584 413 138 , , , 10_1101-2021_01_06_425584 413 139 R. R. NNP 10_1101-2021_01_06_425584 413 140 J. J. NNP 10_1101-2021_01_06_425584 413 141 ; ; : 10_1101-2021_01_06_425584 413 142 Parrot Parrot NNP 10_1101-2021_01_06_425584 413 143 , , , 10_1101-2021_01_06_425584 413 144 D. D. NNP 10_1101-2021_01_06_425584 413 145 ; ; : 10_1101-2021_01_06_425584 413 146 Carlson Carlson NNP 10_1101-2021_01_06_425584 413 147 , , , 10_1101-2021_01_06_425584 413 148 E. E. NNP 10_1101-2021_01_06_425584 413 149 E. E. NNP 10_1101-2021_01_06_425584 413 150 ; ; : 10_1101-2021_01_06_425584 413 151 Aigle Aigle NNP 10_1101-2021_01_06_425584 413 152 , , , 10_1101-2021_01_06_425584 413 153 B. B. NNP 10_1101-2021_01_06_425584 413 154 ; ; : 10_1101-2021_01_06_425584 413 155 Michelsen Michelsen NNP 10_1101-2021_01_06_425584 413 156 , , , 10_1101-2021_01_06_425584 413 157 663 663 CD 10_1101-2021_01_06_425584 413 158 C. C. NNP 10_1101-2021_01_06_425584 413 159 F. F. NNP 10_1101-2021_01_06_425584 413 160 ; ; : 10_1101-2021_01_06_425584 413 161 Jelsbak Jelsbak NNP 10_1101-2021_01_06_425584 413 162 , , , 10_1101-2021_01_06_425584 413 163 L. L. NNP 10_1101-2021_01_06_425584 413 164 ; ; : 10_1101-2021_01_06_425584 413 165 Sohlenkamp Sohlenkamp NNP 10_1101-2021_01_06_425584 413 166 , , , 10_1101-2021_01_06_425584 413 167 C. C. NNP 10_1101-2021_01_06_425584 413 168 ; ; : 10_1101-2021_01_06_425584 413 169 Pevzner Pevzner NNP 10_1101-2021_01_06_425584 413 170 , , , 10_1101-2021_01_06_425584 413 171 P. P. NNP 10_1101-2021_01_06_425584 413 172 ; ; : 10_1101-2021_01_06_425584 413 173 Edlund Edlund NNP 10_1101-2021_01_06_425584 413 174 , , , 10_1101-2021_01_06_425584 413 175 A. a. NN 10_1101-2021_01_06_425584 413 176 ; ; : 10_1101-2021_01_06_425584 413 177 McLean McLean NNP 10_1101-2021_01_06_425584 413 178 , , , 10_1101-2021_01_06_425584 413 179 J. J. NNP 10_1101-2021_01_06_425584 413 180 ; ; : 10_1101-2021_01_06_425584 413 181 Piel Piel NNP 10_1101-2021_01_06_425584 413 182 , , , 10_1101-2021_01_06_425584 413 183 J. J. NNP 10_1101-2021_01_06_425584 413 184 ; ; : 10_1101-2021_01_06_425584 413 185 Murphy Murphy NNP 10_1101-2021_01_06_425584 413 186 , , , 10_1101-2021_01_06_425584 413 187 B. B. NNP 10_1101-2021_01_06_425584 413 188 T. T. NNP 10_1101-2021_01_06_425584 413 189 ; ; : 10_1101-2021_01_06_425584 413 190 664 664 CD 10_1101-2021_01_06_425584 413 191 Gerwick Gerwick NNP 10_1101-2021_01_06_425584 413 192 , , , 10_1101-2021_01_06_425584 413 193 L. L. NNP 10_1101-2021_01_06_425584 413 194 ; ; : 10_1101-2021_01_06_425584 413 195 Liaw Liaw NNP 10_1101-2021_01_06_425584 413 196 , , , 10_1101-2021_01_06_425584 413 197 C. C. NNP 10_1101-2021_01_06_425584 413 198 C. C. NNP 10_1101-2021_01_06_425584 413 199 ; ; : 10_1101-2021_01_06_425584 413 200 Yang Yang NNP 10_1101-2021_01_06_425584 413 201 , , , 10_1101-2021_01_06_425584 413 202 Y. Y. NNP 10_1101-2021_01_06_425584 413 203 L. L. NNP 10_1101-2021_01_06_425584 413 204 ; ; : 10_1101-2021_01_06_425584 413 205 Humpf Humpf NNP 10_1101-2021_01_06_425584 413 206 , , , 10_1101-2021_01_06_425584 413 207 H. H. NNP 10_1101-2021_01_06_425584 413 208 U. U. NNP 10_1101-2021_01_06_425584 413 209 ; ; : 10_1101-2021_01_06_425584 413 210 Maansson Maansson NNP 10_1101-2021_01_06_425584 413 211 , , , 10_1101-2021_01_06_425584 413 212 M. M. NNP 10_1101-2021_01_06_425584 413 213 ; ; : 10_1101-2021_01_06_425584 413 214 Keyzers Keyzers NNP 10_1101-2021_01_06_425584 413 215 , , , 10_1101-2021_01_06_425584 413 216 R. R. NNP 10_1101-2021_01_06_425584 413 217 A. a. NN 10_1101-2021_01_06_425584 413 218 ; ; : 10_1101-2021_01_06_425584 413 219 Sims Sims NNP 10_1101-2021_01_06_425584 413 220 , , , 10_1101-2021_01_06_425584 413 221 A. a. NN 10_1101-2021_01_06_425584 413 222 C. C. NNP 10_1101-2021_01_06_425584 413 223 ; ; : 10_1101-2021_01_06_425584 413 224 665 665 CD 10_1101-2021_01_06_425584 413 225 Johnson Johnson NNP 10_1101-2021_01_06_425584 413 226 , , , 10_1101-2021_01_06_425584 413 227 A. A. NNP 10_1101-2021_01_06_425584 413 228 R. R. NNP 10_1101-2021_01_06_425584 413 229 ; ; : 10_1101-2021_01_06_425584 413 230 Sidebottom Sidebottom NNP 10_1101-2021_01_06_425584 413 231 , , , 10_1101-2021_01_06_425584 413 232 A. a. NN 10_1101-2021_01_06_425584 413 233 M. M. NNP 10_1101-2021_01_06_425584 413 234 ; ; : 10_1101-2021_01_06_425584 413 235 Sedio Sedio NNP 10_1101-2021_01_06_425584 413 236 , , , 10_1101-2021_01_06_425584 413 237 B. B. NNP 10_1101-2021_01_06_425584 413 238 E. E. NNP 10_1101-2021_01_06_425584 413 239 ; ; : 10_1101-2021_01_06_425584 413 240 Klitgaard Klitgaard NNP 10_1101-2021_01_06_425584 413 241 , , , 10_1101-2021_01_06_425584 413 242 A. A. NNP 10_1101-2021_01_06_425584 413 243 ; ; : 10_1101-2021_01_06_425584 413 244 Larson Larson NNP 10_1101-2021_01_06_425584 413 245 , , , 10_1101-2021_01_06_425584 413 246 C. C. NNP 10_1101-2021_01_06_425584 413 247 B. B. NNP 10_1101-2021_01_06_425584 413 248 ; ; : 10_1101-2021_01_06_425584 413 249 P P NNP 10_1101-2021_01_06_425584 413 250 , , , 10_1101-2021_01_06_425584 413 251 C. C. NNP 10_1101-2021_01_06_425584 413 252 A. A. NNP 10_1101-2021_01_06_425584 414 1 B. B. NNP 10_1101-2021_01_06_425584 414 2 ; ; : 10_1101-2021_01_06_425584 414 3 Torres-666 Torres-666 NNP 10_1101-2021_01_06_425584 414 4 Mendoza Mendoza NNP 10_1101-2021_01_06_425584 414 5 , , , 10_1101-2021_01_06_425584 414 6 D. D. NNP 10_1101-2021_01_06_425584 414 7 ; ; : 10_1101-2021_01_06_425584 414 8 Gonzalez Gonzalez NNP 10_1101-2021_01_06_425584 414 9 , , , 10_1101-2021_01_06_425584 414 10 D. D. NNP 10_1101-2021_01_06_425584 414 11 J. J. NNP 10_1101-2021_01_06_425584 414 12 ; ; : 10_1101-2021_01_06_425584 414 13 Silva Silva NNP 10_1101-2021_01_06_425584 414 14 , , , 10_1101-2021_01_06_425584 414 15 D. D. NNP 10_1101-2021_01_06_425584 414 16 B. B. NNP 10_1101-2021_01_06_425584 414 17 ; ; : 10_1101-2021_01_06_425584 414 18 Marques Marques NNP 10_1101-2021_01_06_425584 414 19 , , , 10_1101-2021_01_06_425584 414 20 L. L. NNP 10_1101-2021_01_06_425584 414 21 M. M. NNP 10_1101-2021_01_06_425584 414 22 ; ; : 10_1101-2021_01_06_425584 414 23 Demarque Demarque NNP 10_1101-2021_01_06_425584 414 24 , , , 10_1101-2021_01_06_425584 414 25 D. D. NNP 10_1101-2021_01_06_425584 414 26 P. P. NNP 10_1101-2021_01_06_425584 414 27 ; ; : 10_1101-2021_01_06_425584 414 28 Pociute Pociute NNP 10_1101-2021_01_06_425584 414 29 , , , 10_1101-2021_01_06_425584 414 30 E. E. NNP 10_1101-2021_01_06_425584 414 31 ; ; : 10_1101-2021_01_06_425584 414 32 667 667 CD 10_1101-2021_01_06_425584 414 33 O'Neill O'Neill NNP 10_1101-2021_01_06_425584 414 34 , , , 10_1101-2021_01_06_425584 414 35 E. E. NNP 10_1101-2021_01_06_425584 414 36 C. C. NNP 10_1101-2021_01_06_425584 414 37 ; ; : 10_1101-2021_01_06_425584 414 38 Briand Briand NNP 10_1101-2021_01_06_425584 414 39 , , , 10_1101-2021_01_06_425584 414 40 E. E. NNP 10_1101-2021_01_06_425584 414 41 ; ; : 10_1101-2021_01_06_425584 414 42 Helfrich Helfrich NNP 10_1101-2021_01_06_425584 414 43 , , , 10_1101-2021_01_06_425584 414 44 E. E. NNP 10_1101-2021_01_06_425584 414 45 J. J. NNP 10_1101-2021_01_06_425584 414 46 N. N. NNP 10_1101-2021_01_06_425584 414 47 ; ; : 10_1101-2021_01_06_425584 414 48 Granatosky Granatosky NNP 10_1101-2021_01_06_425584 414 49 , , , 10_1101-2021_01_06_425584 414 50 E. E. NNP 10_1101-2021_01_06_425584 414 51 A. A. NNP 10_1101-2021_01_06_425584 414 52 ; ; : 10_1101-2021_01_06_425584 414 53 Glukhov Glukhov NNP 10_1101-2021_01_06_425584 414 54 , , , 10_1101-2021_01_06_425584 414 55 E. E. NNP 10_1101-2021_01_06_425584 414 56 ; ; : 10_1101-2021_01_06_425584 414 57 Ryffel Ryffel NNP 10_1101-2021_01_06_425584 414 58 , , , 10_1101-2021_01_06_425584 414 59 F. F. NNP 10_1101-2021_01_06_425584 414 60 ; ; : 10_1101-2021_01_06_425584 414 61 Houson Houson NNP 10_1101-2021_01_06_425584 414 62 , , , 10_1101-2021_01_06_425584 414 63 668 668 CD 10_1101-2021_01_06_425584 414 64 H. h. NN 10_1101-2021_01_06_425584 414 65 ; ; : 10_1101-2021_01_06_425584 414 66 Mohimani Mohimani NNP 10_1101-2021_01_06_425584 414 67 , , , 10_1101-2021_01_06_425584 414 68 H. H. NNP 10_1101-2021_01_06_425584 414 69 ; ; : 10_1101-2021_01_06_425584 414 70 Kharbush Kharbush NNP 10_1101-2021_01_06_425584 414 71 , , , 10_1101-2021_01_06_425584 414 72 J. J. NNP 10_1101-2021_01_06_425584 414 73 J. J. NNP 10_1101-2021_01_06_425584 414 74 ; ; : 10_1101-2021_01_06_425584 414 75 Zeng Zeng NNP 10_1101-2021_01_06_425584 414 76 , , , 10_1101-2021_01_06_425584 414 77 Y. Y. NNP 10_1101-2021_01_06_425584 414 78 ; ; : 10_1101-2021_01_06_425584 414 79 Vorholt Vorholt NNP 10_1101-2021_01_06_425584 414 80 , , , 10_1101-2021_01_06_425584 414 81 J. J. NNP 10_1101-2021_01_06_425584 415 1 A. a. LS 10_1101-2021_01_06_425584 415 2 ; ; : 10_1101-2021_01_06_425584 415 3 Kurita Kurita NNP 10_1101-2021_01_06_425584 415 4 , , , 10_1101-2021_01_06_425584 415 5 K. K. NNP 10_1101-2021_01_06_425584 415 6 L. L. NNP 10_1101-2021_01_06_425584 415 7 ; ; : 10_1101-2021_01_06_425584 415 8 Charusanti Charusanti NNP 10_1101-2021_01_06_425584 415 9 , , , 10_1101-2021_01_06_425584 415 10 P. P. NNP 10_1101-2021_01_06_425584 415 11 ; ; : 10_1101-2021_01_06_425584 415 12 McPhail McPhail NNP 10_1101-2021_01_06_425584 415 13 , , , 10_1101-2021_01_06_425584 415 14 669 669 CD 10_1101-2021_01_06_425584 415 15 K. K. NNP 10_1101-2021_01_06_425584 415 16 L. L. NNP 10_1101-2021_01_06_425584 415 17 ; ; : 10_1101-2021_01_06_425584 415 18 Nielsen Nielsen NNP 10_1101-2021_01_06_425584 415 19 , , , 10_1101-2021_01_06_425584 415 20 K. K. NNP 10_1101-2021_01_06_425584 415 21 F. F. NNP 10_1101-2021_01_06_425584 415 22 ; ; : 10_1101-2021_01_06_425584 415 23 Vuong Vuong NNP 10_1101-2021_01_06_425584 415 24 , , , 10_1101-2021_01_06_425584 415 25 L. L. NNP 10_1101-2021_01_06_425584 415 26 ; ; : 10_1101-2021_01_06_425584 415 27 Elfeki Elfeki NNP 10_1101-2021_01_06_425584 415 28 , , , 10_1101-2021_01_06_425584 415 29 M. M. NNP 10_1101-2021_01_06_425584 415 30 ; ; : 10_1101-2021_01_06_425584 415 31 Traxler Traxler NNP 10_1101-2021_01_06_425584 415 32 , , , 10_1101-2021_01_06_425584 415 33 M. M. NNP 10_1101-2021_01_06_425584 415 34 F. F. NNP 10_1101-2021_01_06_425584 415 35 ; ; : 10_1101-2021_01_06_425584 415 36 Engene engene UH 10_1101-2021_01_06_425584 415 37 , , , 10_1101-2021_01_06_425584 415 38 N. N. NNP 10_1101-2021_01_06_425584 415 39 ; ; : 10_1101-2021_01_06_425584 415 40 Koyama Koyama NNP 10_1101-2021_01_06_425584 415 41 , , , 10_1101-2021_01_06_425584 415 42 N. N. NNP 10_1101-2021_01_06_425584 415 43 ; ; : 10_1101-2021_01_06_425584 415 44 Vining Vining NNP 10_1101-2021_01_06_425584 415 45 , , , 10_1101-2021_01_06_425584 415 46 O. O. NNP 10_1101-2021_01_06_425584 416 1 B. B. NNP 10_1101-2021_01_06_425584 416 2 ; ; : 10_1101-2021_01_06_425584 416 3 670 670 CD 10_1101-2021_01_06_425584 416 4 Baric Baric NNP 10_1101-2021_01_06_425584 416 5 , , , 10_1101-2021_01_06_425584 416 6 R. R. NNP 10_1101-2021_01_06_425584 416 7 ; ; : 10_1101-2021_01_06_425584 416 8 Silva Silva NNP 10_1101-2021_01_06_425584 416 9 , , , 10_1101-2021_01_06_425584 416 10 R. R. NNP 10_1101-2021_01_06_425584 416 11 R. R. NNP 10_1101-2021_01_06_425584 416 12 ; ; : 10_1101-2021_01_06_425584 416 13 Mascuch Mascuch NNP 10_1101-2021_01_06_425584 416 14 , , , 10_1101-2021_01_06_425584 416 15 S. S. NNP 10_1101-2021_01_06_425584 416 16 J. J. NNP 10_1101-2021_01_06_425584 416 17 ; ; : 10_1101-2021_01_06_425584 416 18 Tomasi Tomasi NNP 10_1101-2021_01_06_425584 416 19 , , , 10_1101-2021_01_06_425584 416 20 S. S. NNP 10_1101-2021_01_06_425584 416 21 ; ; : 10_1101-2021_01_06_425584 416 22 Jenkins Jenkins NNP 10_1101-2021_01_06_425584 416 23 , , , 10_1101-2021_01_06_425584 416 24 S. S. NNP 10_1101-2021_01_06_425584 416 25 ; ; : 10_1101-2021_01_06_425584 416 26 Macherla Macherla NNP 10_1101-2021_01_06_425584 416 27 , , , 10_1101-2021_01_06_425584 416 28 V. V. NNP 10_1101-2021_01_06_425584 416 29 ; ; : 10_1101-2021_01_06_425584 416 30 Hoffman Hoffman NNP 10_1101-2021_01_06_425584 416 31 , , , 10_1101-2021_01_06_425584 416 32 T. t. NN 10_1101-2021_01_06_425584 416 33 ; ; : 10_1101-2021_01_06_425584 416 34 671 671 CD 10_1101-2021_01_06_425584 416 35 Agarwal Agarwal NNP 10_1101-2021_01_06_425584 416 36 , , , 10_1101-2021_01_06_425584 416 37 V. V. NNP 10_1101-2021_01_06_425584 416 38 ; ; : 10_1101-2021_01_06_425584 416 39 Williams Williams NNP 10_1101-2021_01_06_425584 416 40 , , , 10_1101-2021_01_06_425584 416 41 P. P. NNP 10_1101-2021_01_06_425584 416 42 G. G. NNP 10_1101-2021_01_06_425584 416 43 ; ; : 10_1101-2021_01_06_425584 416 44 Dai Dai NNP 10_1101-2021_01_06_425584 416 45 , , , 10_1101-2021_01_06_425584 416 46 J. J. NNP 10_1101-2021_01_06_425584 416 47 ; ; : 10_1101-2021_01_06_425584 416 48 Neupane Neupane NNP 10_1101-2021_01_06_425584 416 49 , , , 10_1101-2021_01_06_425584 416 50 R. R. NNP 10_1101-2021_01_06_425584 416 51 ; ; : 10_1101-2021_01_06_425584 416 52 Gurr Gurr NNP 10_1101-2021_01_06_425584 416 53 , , , 10_1101-2021_01_06_425584 416 54 J. J. NNP 10_1101-2021_01_06_425584 416 55 ; ; : 10_1101-2021_01_06_425584 416 56 Rodriguez Rodriguez NNP 10_1101-2021_01_06_425584 416 57 , , , 10_1101-2021_01_06_425584 416 58 A. a. NN 10_1101-2021_01_06_425584 416 59 M. M. NNP 10_1101-2021_01_06_425584 416 60 C. C. NNP 10_1101-2021_01_06_425584 416 61 ; ; : 10_1101-2021_01_06_425584 416 62 Lamsa Lamsa NNP 10_1101-2021_01_06_425584 416 63 , , , 10_1101-2021_01_06_425584 416 64 A. a. NN 10_1101-2021_01_06_425584 416 65 ; ; : 10_1101-2021_01_06_425584 416 66 672 672 CD 10_1101-2021_01_06_425584 416 67 Zhang Zhang NNP 10_1101-2021_01_06_425584 416 68 , , , 10_1101-2021_01_06_425584 416 69 C. C. NNP 10_1101-2021_01_06_425584 416 70 ; ; : 10_1101-2021_01_06_425584 416 71 Dorrestein Dorrestein NNP 10_1101-2021_01_06_425584 416 72 , , , 10_1101-2021_01_06_425584 416 73 K. K. NNP 10_1101-2021_01_06_425584 416 74 ; ; : 10_1101-2021_01_06_425584 416 75 Duggan Duggan NNP 10_1101-2021_01_06_425584 416 76 , , , 10_1101-2021_01_06_425584 416 77 B. B. NNP 10_1101-2021_01_06_425584 416 78 M. M. NNP 10_1101-2021_01_06_425584 416 79 ; ; : 10_1101-2021_01_06_425584 416 80 Almaliti Almaliti NNP 10_1101-2021_01_06_425584 416 81 , , , 10_1101-2021_01_06_425584 416 82 J. J. NNP 10_1101-2021_01_06_425584 416 83 ; ; : 10_1101-2021_01_06_425584 416 84 Allard Allard NNP 10_1101-2021_01_06_425584 416 85 , , , 10_1101-2021_01_06_425584 416 86 P. P. NNP 10_1101-2021_01_06_425584 416 87 M. M. NNP 10_1101-2021_01_06_425584 416 88 ; ; : 10_1101-2021_01_06_425584 416 89 Phapale Phapale NNP 10_1101-2021_01_06_425584 416 90 , , , 10_1101-2021_01_06_425584 416 91 P. P. NNP 10_1101-2021_01_06_425584 416 92 ; ; : 10_1101-2021_01_06_425584 416 93 Nothias Nothias NNP 10_1101-2021_01_06_425584 416 94 , , , 10_1101-2021_01_06_425584 416 95 L. L. NNP 10_1101-2021_01_06_425584 416 96 F. F. NNP 10_1101-2021_01_06_425584 416 97 ; ; : 10_1101-2021_01_06_425584 416 98 673 673 NNP 10_1101-2021_01_06_425584 416 99 Alexandrov Alexandrov NNP 10_1101-2021_01_06_425584 416 100 , , , 10_1101-2021_01_06_425584 416 101 T. T. NNP 10_1101-2021_01_06_425584 416 102 ; ; : 10_1101-2021_01_06_425584 416 103 Litaudon Litaudon NNP 10_1101-2021_01_06_425584 416 104 , , , 10_1101-2021_01_06_425584 416 105 M. M. NNP 10_1101-2021_01_06_425584 416 106 ; ; : 10_1101-2021_01_06_425584 416 107 Wolfender Wolfender NNP 10_1101-2021_01_06_425584 416 108 , , , 10_1101-2021_01_06_425584 416 109 J. J. NNP 10_1101-2021_01_06_425584 416 110 L. L. NNP 10_1101-2021_01_06_425584 416 111 ; ; : 10_1101-2021_01_06_425584 416 112 Kyle Kyle NNP 10_1101-2021_01_06_425584 416 113 , , , 10_1101-2021_01_06_425584 416 114 J. J. NNP 10_1101-2021_01_06_425584 416 115 E. E. NNP 10_1101-2021_01_06_425584 416 116 ; ; : 10_1101-2021_01_06_425584 416 117 Metz Metz NNP 10_1101-2021_01_06_425584 416 118 , , , 10_1101-2021_01_06_425584 416 119 T. T. NNP 10_1101-2021_01_06_425584 416 120 O. O. NNP 10_1101-2021_01_06_425584 416 121 ; ; : 10_1101-2021_01_06_425584 416 122 Peryea Peryea NNP 10_1101-2021_01_06_425584 416 123 , , , 10_1101-2021_01_06_425584 416 124 T. T. NNP 10_1101-2021_01_06_425584 416 125 ; ; : 10_1101-2021_01_06_425584 416 126 Nguyen Nguyen NNP 10_1101-2021_01_06_425584 416 127 , , , 10_1101-2021_01_06_425584 416 128 D. D. NNP 10_1101-2021_01_06_425584 416 129 674 674 CD 10_1101-2021_01_06_425584 416 130 T. T. NNP 10_1101-2021_01_06_425584 416 131 ; ; : 10_1101-2021_01_06_425584 416 132 VanLeer VanLeer NNP 10_1101-2021_01_06_425584 416 133 , , , 10_1101-2021_01_06_425584 416 134 D. D. NNP 10_1101-2021_01_06_425584 416 135 ; ; : 10_1101-2021_01_06_425584 416 136 Shinn Shinn NNP 10_1101-2021_01_06_425584 416 137 , , , 10_1101-2021_01_06_425584 416 138 P. P. NNP 10_1101-2021_01_06_425584 416 139 ; ; : 10_1101-2021_01_06_425584 416 140 Jadhav Jadhav NNP 10_1101-2021_01_06_425584 416 141 , , , 10_1101-2021_01_06_425584 416 142 A. A. NNP 10_1101-2021_01_06_425584 416 143 ; ; : 10_1101-2021_01_06_425584 416 144 Muller Muller NNP 10_1101-2021_01_06_425584 416 145 , , , 10_1101-2021_01_06_425584 416 146 R. R. NNP 10_1101-2021_01_06_425584 416 147 ; ; : 10_1101-2021_01_06_425584 416 148 Waters Waters NNP 10_1101-2021_01_06_425584 416 149 , , , 10_1101-2021_01_06_425584 416 150 K. K. NNP 10_1101-2021_01_06_425584 416 151 M. M. NNP 10_1101-2021_01_06_425584 416 152 ; ; : 10_1101-2021_01_06_425584 416 153 Shi Shi NNP 10_1101-2021_01_06_425584 416 154 , , , 10_1101-2021_01_06_425584 416 155 W. W. NNP 10_1101-2021_01_06_425584 416 156 ; ; : 10_1101-2021_01_06_425584 416 157 Liu Liu NNP 10_1101-2021_01_06_425584 416 158 , , , 10_1101-2021_01_06_425584 416 159 X. X. NNP 10_1101-2021_01_06_425584 416 160 ; ; : 10_1101-2021_01_06_425584 416 161 Zhang Zhang NNP 10_1101-2021_01_06_425584 416 162 , , , 10_1101-2021_01_06_425584 416 163 L. L. NNP 10_1101-2021_01_06_425584 416 164 ; ; : 10_1101-2021_01_06_425584 416 165 675 675 CD 10_1101-2021_01_06_425584 416 166 Knight Knight NNP 10_1101-2021_01_06_425584 416 167 , , , 10_1101-2021_01_06_425584 416 168 R. R. NNP 10_1101-2021_01_06_425584 416 169 ; ; : 10_1101-2021_01_06_425584 416 170 Jensen Jensen NNP 10_1101-2021_01_06_425584 416 171 , , , 10_1101-2021_01_06_425584 416 172 P. P. NNP 10_1101-2021_01_06_425584 416 173 R. R. NNP 10_1101-2021_01_06_425584 416 174 ; ; : 10_1101-2021_01_06_425584 416 175 Palsson Palsson NNP 10_1101-2021_01_06_425584 416 176 , , , 10_1101-2021_01_06_425584 416 177 B. B. NNP 10_1101-2021_01_06_425584 416 178 O. O. NNP 10_1101-2021_01_06_425584 416 179 ; ; : 10_1101-2021_01_06_425584 416 180 Pogliano Pogliano NNP 10_1101-2021_01_06_425584 416 181 , , , 10_1101-2021_01_06_425584 416 182 K. K. NNP 10_1101-2021_01_06_425584 416 183 ; ; : 10_1101-2021_01_06_425584 416 184 Linington Linington NNP 10_1101-2021_01_06_425584 416 185 , , , 10_1101-2021_01_06_425584 416 186 R. R. NNP 10_1101-2021_01_06_425584 416 187 G. G. NNP 10_1101-2021_01_06_425584 416 188 ; ; : 10_1101-2021_01_06_425584 416 189 Gutierrez Gutierrez NNP 10_1101-2021_01_06_425584 416 190 , , , 10_1101-2021_01_06_425584 416 191 M. M. NNP 10_1101-2021_01_06_425584 416 192 ; ; : 10_1101-2021_01_06_425584 416 193 Lopes Lopes NNP 10_1101-2021_01_06_425584 416 194 , , , 10_1101-2021_01_06_425584 416 195 N. N. NNP 10_1101-2021_01_06_425584 416 196 676 676 CD 10_1101-2021_01_06_425584 416 197 P. P. NNP 10_1101-2021_01_06_425584 416 198 ; ; : 10_1101-2021_01_06_425584 416 199 Gerwick Gerwick NNP 10_1101-2021_01_06_425584 416 200 , , , 10_1101-2021_01_06_425584 416 201 W. W. NNP 10_1101-2021_01_06_425584 416 202 H. H. NNP 10_1101-2021_01_06_425584 416 203 ; ; : 10_1101-2021_01_06_425584 416 204 Moore Moore NNP 10_1101-2021_01_06_425584 416 205 , , , 10_1101-2021_01_06_425584 416 206 B. B. NNP 10_1101-2021_01_06_425584 416 207 S. S. NNP 10_1101-2021_01_06_425584 416 208 ; ; : 10_1101-2021_01_06_425584 416 209 Dorrestein Dorrestein NNP 10_1101-2021_01_06_425584 416 210 , , , 10_1101-2021_01_06_425584 416 211 P. P. NNP 10_1101-2021_01_06_425584 416 212 C. C. NNP 10_1101-2021_01_06_425584 416 213 ; ; : 10_1101-2021_01_06_425584 416 214 Bandeira Bandeira NNP 10_1101-2021_01_06_425584 416 215 , , , 10_1101-2021_01_06_425584 416 216 N. N. NNP 10_1101-2021_01_06_425584 416 217 , , , 10_1101-2021_01_06_425584 416 218 Sharing sharing NN 10_1101-2021_01_06_425584 416 219 and and CC 10_1101-2021_01_06_425584 416 220 community community NN 10_1101-2021_01_06_425584 416 221 677 677 CD 10_1101-2021_01_06_425584 416 222 .CC .CC , 10_1101-2021_01_06_425584 416 223 - - HYPH 10_1101-2021_01_06_425584 416 224 BY by IN 10_1101-2021_01_06_425584 416 225 - - HYPH 10_1101-2021_01_06_425584 416 226 NC NC NNP 10_1101-2021_01_06_425584 416 227 - - HYPH 10_1101-2021_01_06_425584 416 228 ND ND NNP 10_1101-2021_01_06_425584 416 229 4.0 4.0 CD 10_1101-2021_01_06_425584 416 230 International International NNP 10_1101-2021_01_06_425584 416 231 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 416 232 under under IN 10_1101-2021_01_06_425584 416 233 a a DT 10_1101-2021_01_06_425584 416 234 ( ( -LRB- 10_1101-2021_01_06_425584 416 235 which which WDT 10_1101-2021_01_06_425584 416 236 was be VBD 10_1101-2021_01_06_425584 416 237 not not RB 10_1101-2021_01_06_425584 416 238 certified certify VBN 10_1101-2021_01_06_425584 416 239 by by IN 10_1101-2021_01_06_425584 416 240 peer peer NN 10_1101-2021_01_06_425584 416 241 review review NN 10_1101-2021_01_06_425584 416 242 ) ) -RRB- 10_1101-2021_01_06_425584 416 243 is be VBZ 10_1101-2021_01_06_425584 416 244 the the DT 10_1101-2021_01_06_425584 416 245 author author NN 10_1101-2021_01_06_425584 416 246 / / SYM 10_1101-2021_01_06_425584 416 247 funder funder NN 10_1101-2021_01_06_425584 416 248 , , , 10_1101-2021_01_06_425584 416 249 who who WP 10_1101-2021_01_06_425584 416 250 has have VBZ 10_1101-2021_01_06_425584 416 251 granted grant VBN 10_1101-2021_01_06_425584 416 252 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 416 253 a a DT 10_1101-2021_01_06_425584 416 254 license license NN 10_1101-2021_01_06_425584 416 255 to to TO 10_1101-2021_01_06_425584 416 256 display display VB 10_1101-2021_01_06_425584 416 257 the the DT 10_1101-2021_01_06_425584 416 258 preprint preprint NN 10_1101-2021_01_06_425584 416 259 in in IN 10_1101-2021_01_06_425584 416 260 perpetuity perpetuity NN 10_1101-2021_01_06_425584 416 261 . . . 10_1101-2021_01_06_425584 417 1 It -PRON- PRP 10_1101-2021_01_06_425584 417 2 is be VBZ 10_1101-2021_01_06_425584 417 3 made make VBN 10_1101-2021_01_06_425584 417 4 The the DT 10_1101-2021_01_06_425584 417 5 copyright copyright NN 10_1101-2021_01_06_425584 417 6 holder holder NN 10_1101-2021_01_06_425584 417 7 for for IN 10_1101-2021_01_06_425584 417 8 this this DT 10_1101-2021_01_06_425584 417 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 417 10 version version NN 10_1101-2021_01_06_425584 417 11 posted post VBD 10_1101-2021_01_06_425584 417 12 January January NNP 10_1101-2021_01_06_425584 417 13 8 8 CD 10_1101-2021_01_06_425584 417 14 , , , 10_1101-2021_01_06_425584 417 15 2021 2021 CD 10_1101-2021_01_06_425584 417 16 . . . 10_1101-2021_01_06_425584 417 17 ; ; : 10_1101-2021_01_06_425584 417 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 417 19 : : : 10_1101-2021_01_06_425584 417 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 417 21 preprint preprint NN 10_1101-2021_01_06_425584 417 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 417 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 417 24 24 24 CD 10_1101-2021_01_06_425584 417 25 curation curation NN 10_1101-2021_01_06_425584 417 26 of of IN 10_1101-2021_01_06_425584 417 27 mass mass JJ 10_1101-2021_01_06_425584 417 28 spectrometry spectrometry NN 10_1101-2021_01_06_425584 417 29 data datum NNS 10_1101-2021_01_06_425584 417 30 with with IN 10_1101-2021_01_06_425584 417 31 Global Global NNP 10_1101-2021_01_06_425584 417 32 Natural Natural NNP 10_1101-2021_01_06_425584 417 33 Products Products NNPS 10_1101-2021_01_06_425584 417 34 Social Social NNP 10_1101-2021_01_06_425584 417 35 Molecular Molecular NNP 10_1101-2021_01_06_425584 417 36 Networking Networking NNP 10_1101-2021_01_06_425584 417 37 . . . 10_1101-2021_01_06_425584 418 1 678 678 CD 10_1101-2021_01_06_425584 418 2 Nat Nat NNP 10_1101-2021_01_06_425584 418 3 Biotechnol Biotechnol NNP 10_1101-2021_01_06_425584 418 4 2016 2016 CD 10_1101-2021_01_06_425584 418 5 , , , 10_1101-2021_01_06_425584 418 6 34 34 CD 10_1101-2021_01_06_425584 418 7 , , , 10_1101-2021_01_06_425584 418 8 ( ( -LRB- 10_1101-2021_01_06_425584 418 9 8) 8) CD 10_1101-2021_01_06_425584 418 10 , , , 10_1101-2021_01_06_425584 418 11 828 828 CD 10_1101-2021_01_06_425584 418 12 - - SYM 10_1101-2021_01_06_425584 418 13 837 837 CD 10_1101-2021_01_06_425584 418 14 . . . 10_1101-2021_01_06_425584 419 1 679 679 CD 10_1101-2021_01_06_425584 419 2 39 39 CD 10_1101-2021_01_06_425584 419 3 . . . 10_1101-2021_01_06_425584 420 1 Bender Bender NNP 10_1101-2021_01_06_425584 420 2 , , , 10_1101-2021_01_06_425584 420 3 D. D. NNP 10_1101-2021_01_06_425584 420 4 A. A. NNP 10_1101-2021_01_06_425584 420 5 , , , 10_1101-2021_01_06_425584 420 6 Biochemistry Biochemistry NNP 10_1101-2021_01_06_425584 420 7 of of IN 10_1101-2021_01_06_425584 420 8 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 420 9 in in IN 10_1101-2021_01_06_425584 420 10 health health NNP 10_1101-2021_01_06_425584 420 11 and and CC 10_1101-2021_01_06_425584 420 12 disease disease NN 10_1101-2021_01_06_425584 420 13 . . . 10_1101-2021_01_06_425584 421 1 Mol Mol NNP 10_1101-2021_01_06_425584 421 2 Aspects Aspects NNP 10_1101-2021_01_06_425584 421 3 Med Med NNP 10_1101-2021_01_06_425584 421 4 1983 1983 CD 10_1101-2021_01_06_425584 421 5 , , , 10_1101-2021_01_06_425584 421 6 680 680 CD 10_1101-2021_01_06_425584 421 7 6 6 CD 10_1101-2021_01_06_425584 421 8 , , , 10_1101-2021_01_06_425584 421 9 ( ( -LRB- 10_1101-2021_01_06_425584 421 10 2 2 CD 10_1101-2021_01_06_425584 421 11 ) ) -RRB- 10_1101-2021_01_06_425584 421 12 , , , 10_1101-2021_01_06_425584 421 13 101 101 CD 10_1101-2021_01_06_425584 421 14 - - SYM 10_1101-2021_01_06_425584 421 15 97 97 CD 10_1101-2021_01_06_425584 421 16 . . . 10_1101-2021_01_06_425584 422 1 681 681 CD 10_1101-2021_01_06_425584 422 2 40 40 CD 10_1101-2021_01_06_425584 422 3 . . . 10_1101-2021_01_06_425584 423 1 Poyatos Poyatos NNP 10_1101-2021_01_06_425584 423 2 , , , 10_1101-2021_01_06_425584 423 3 J. J. NNP 10_1101-2021_01_06_425584 423 4 F. F. NNP 10_1101-2021_01_06_425584 423 5 ; ; : 10_1101-2021_01_06_425584 423 6 Hurst Hurst NNP 10_1101-2021_01_06_425584 423 7 , , , 10_1101-2021_01_06_425584 423 8 L. L. NNP 10_1101-2021_01_06_425584 423 9 D. D. NNP 10_1101-2021_01_06_425584 423 10 , , , 10_1101-2021_01_06_425584 423 11 How how WRB 10_1101-2021_01_06_425584 423 12 biologically biologically RB 10_1101-2021_01_06_425584 423 13 relevant relevant JJ 10_1101-2021_01_06_425584 423 14 are be VBP 10_1101-2021_01_06_425584 423 15 interaction interaction NN 10_1101-2021_01_06_425584 423 16 - - HYPH 10_1101-2021_01_06_425584 423 17 based base VBN 10_1101-2021_01_06_425584 423 18 modules module NNS 10_1101-2021_01_06_425584 423 19 in in IN 10_1101-2021_01_06_425584 423 20 682 682 CD 10_1101-2021_01_06_425584 423 21 protein protein NN 10_1101-2021_01_06_425584 423 22 networks network NNS 10_1101-2021_01_06_425584 423 23 ? ? . 10_1101-2021_01_06_425584 424 1 Genome Genome NNP 10_1101-2021_01_06_425584 424 2 Biol Biol NNP 10_1101-2021_01_06_425584 424 3 2004 2004 CD 10_1101-2021_01_06_425584 424 4 , , , 10_1101-2021_01_06_425584 424 5 5 5 CD 10_1101-2021_01_06_425584 424 6 , , , 10_1101-2021_01_06_425584 424 7 ( ( -LRB- 10_1101-2021_01_06_425584 424 8 11 11 CD 10_1101-2021_01_06_425584 424 9 ) ) -RRB- 10_1101-2021_01_06_425584 424 10 , , , 10_1101-2021_01_06_425584 424 11 R93 R93 NNP 10_1101-2021_01_06_425584 424 12 . . . 10_1101-2021_01_06_425584 425 1 683 683 CD 10_1101-2021_01_06_425584 425 2 41 41 CD 10_1101-2021_01_06_425584 425 3 . . . 10_1101-2021_01_06_425584 426 1 Muller Muller NNP 10_1101-2021_01_06_425584 426 2 , , , 10_1101-2021_01_06_425584 426 3 A. a. NN 10_1101-2021_01_06_425584 426 4 M. M. NNP 10_1101-2021_01_06_425584 426 5 ; ; : 10_1101-2021_01_06_425584 426 6 Hermanns Hermanns NNP 10_1101-2021_01_06_425584 426 7 , , , 10_1101-2021_01_06_425584 426 8 M. M. NNP 10_1101-2021_01_06_425584 426 9 I. I. NNP 10_1101-2021_01_06_425584 426 10 ; ; : 10_1101-2021_01_06_425584 426 11 Skrzynski Skrzynski NNP 10_1101-2021_01_06_425584 426 12 , , , 10_1101-2021_01_06_425584 426 13 C. C. NNP 10_1101-2021_01_06_425584 426 14 ; ; : 10_1101-2021_01_06_425584 426 15 Nesslinger Nesslinger NNP 10_1101-2021_01_06_425584 426 16 , , , 10_1101-2021_01_06_425584 426 17 M. M. NNP 10_1101-2021_01_06_425584 426 18 ; ; : 10_1101-2021_01_06_425584 426 19 Muller Muller NNP 10_1101-2021_01_06_425584 426 20 , , , 10_1101-2021_01_06_425584 426 21 K. K. NNP 10_1101-2021_01_06_425584 426 22 M. M. NNP 10_1101-2021_01_06_425584 426 23 ; ; : 10_1101-2021_01_06_425584 426 24 Kirkpatrick Kirkpatrick NNP 10_1101-2021_01_06_425584 426 25 , , , 10_1101-2021_01_06_425584 426 26 684 684 CD 10_1101-2021_01_06_425584 426 27 C. C. NNP 10_1101-2021_01_06_425584 426 28 J. J. NNP 10_1101-2021_01_06_425584 426 29 , , , 10_1101-2021_01_06_425584 426 30 Expression Expression NNP 10_1101-2021_01_06_425584 426 31 of of IN 10_1101-2021_01_06_425584 426 32 the the DT 10_1101-2021_01_06_425584 426 33 endothelial endothelial JJ 10_1101-2021_01_06_425584 426 34 markers marker NNS 10_1101-2021_01_06_425584 426 35 PECAM-1 PECAM-1 NNS 10_1101-2021_01_06_425584 426 36 , , , 10_1101-2021_01_06_425584 426 37 vWf vWf NNS 10_1101-2021_01_06_425584 426 38 , , , 10_1101-2021_01_06_425584 426 39 and and CC 10_1101-2021_01_06_425584 426 40 CD34 CD34 NNP 10_1101-2021_01_06_425584 426 41 in in IN 10_1101-2021_01_06_425584 426 42 vivo vivo NNP 10_1101-2021_01_06_425584 426 43 and and CC 10_1101-2021_01_06_425584 426 44 in in FW 10_1101-2021_01_06_425584 426 45 vitro vitro FW 10_1101-2021_01_06_425584 426 46 . . . 10_1101-2021_01_06_425584 427 1 Exp Exp NNP 10_1101-2021_01_06_425584 427 2 685 685 CD 10_1101-2021_01_06_425584 427 3 Mol Mol NNP 10_1101-2021_01_06_425584 427 4 Pathol Pathol NNP 10_1101-2021_01_06_425584 427 5 2002 2002 CD 10_1101-2021_01_06_425584 427 6 , , , 10_1101-2021_01_06_425584 427 7 72 72 CD 10_1101-2021_01_06_425584 427 8 , , , 10_1101-2021_01_06_425584 427 9 ( ( -LRB- 10_1101-2021_01_06_425584 427 10 3 3 CD 10_1101-2021_01_06_425584 427 11 ) ) -RRB- 10_1101-2021_01_06_425584 427 12 , , , 10_1101-2021_01_06_425584 427 13 221 221 CD 10_1101-2021_01_06_425584 427 14 - - SYM 10_1101-2021_01_06_425584 427 15 9 9 CD 10_1101-2021_01_06_425584 427 16 . . . 10_1101-2021_01_06_425584 428 1 686 686 CD 10_1101-2021_01_06_425584 428 2 42 42 CD 10_1101-2021_01_06_425584 428 3 . . . 10_1101-2021_01_06_425584 429 1 Aird Aird NNP 10_1101-2021_01_06_425584 429 2 , , , 10_1101-2021_01_06_425584 429 3 W. W. NNP 10_1101-2021_01_06_425584 429 4 C. C. NNP 10_1101-2021_01_06_425584 429 5 , , , 10_1101-2021_01_06_425584 429 6 Phenotypic Phenotypic NNP 10_1101-2021_01_06_425584 429 7 heterogeneity heterogeneity NN 10_1101-2021_01_06_425584 429 8 of of IN 10_1101-2021_01_06_425584 429 9 the the DT 10_1101-2021_01_06_425584 429 10 endothelium endothelium NN 10_1101-2021_01_06_425584 429 11 : : : 10_1101-2021_01_06_425584 429 12 II ii CD 10_1101-2021_01_06_425584 429 13 . . . 10_1101-2021_01_06_425584 430 1 Representative representative JJ 10_1101-2021_01_06_425584 430 2 vascular vascular JJ 10_1101-2021_01_06_425584 430 3 687 687 CD 10_1101-2021_01_06_425584 430 4 beds bed NNS 10_1101-2021_01_06_425584 430 5 . . . 10_1101-2021_01_06_425584 431 1 Circ Circ NNP 10_1101-2021_01_06_425584 431 2 Res Res NNP 10_1101-2021_01_06_425584 431 3 2007 2007 CD 10_1101-2021_01_06_425584 431 4 , , , 10_1101-2021_01_06_425584 431 5 100 100 CD 10_1101-2021_01_06_425584 431 6 , , , 10_1101-2021_01_06_425584 431 7 ( ( -LRB- 10_1101-2021_01_06_425584 431 8 2 2 CD 10_1101-2021_01_06_425584 431 9 ) ) -RRB- 10_1101-2021_01_06_425584 431 10 , , , 10_1101-2021_01_06_425584 431 11 174 174 CD 10_1101-2021_01_06_425584 431 12 - - SYM 10_1101-2021_01_06_425584 431 13 90 90 CD 10_1101-2021_01_06_425584 431 14 . . . 10_1101-2021_01_06_425584 432 1 688 688 CD 10_1101-2021_01_06_425584 432 2 43 43 CD 10_1101-2021_01_06_425584 432 3 . . . 10_1101-2021_01_06_425584 433 1 Aird Aird NNP 10_1101-2021_01_06_425584 433 2 , , , 10_1101-2021_01_06_425584 433 3 W. W. NNP 10_1101-2021_01_06_425584 433 4 C. C. NNP 10_1101-2021_01_06_425584 433 5 , , , 10_1101-2021_01_06_425584 433 6 Endothelial endothelial JJ 10_1101-2021_01_06_425584 433 7 cell cell NN 10_1101-2021_01_06_425584 433 8 heterogeneity heterogeneity NN 10_1101-2021_01_06_425584 433 9 . . . 10_1101-2021_01_06_425584 434 1 Cold Cold NNP 10_1101-2021_01_06_425584 434 2 Spring Spring NNP 10_1101-2021_01_06_425584 434 3 Harb Harb NNP 10_1101-2021_01_06_425584 434 4 Perspect Perspect NNP 10_1101-2021_01_06_425584 434 5 Med Med NNP 10_1101-2021_01_06_425584 434 6 2012 2012 CD 10_1101-2021_01_06_425584 434 7 , , , 10_1101-2021_01_06_425584 434 8 2 2 CD 10_1101-2021_01_06_425584 434 9 , , , 10_1101-2021_01_06_425584 434 10 ( ( -LRB- 10_1101-2021_01_06_425584 434 11 1 1 CD 10_1101-2021_01_06_425584 434 12 ) ) -RRB- 10_1101-2021_01_06_425584 434 13 , , , 10_1101-2021_01_06_425584 434 14 689 689 CD 10_1101-2021_01_06_425584 434 15 a006429 a006429 NN 10_1101-2021_01_06_425584 434 16 . . . 10_1101-2021_01_06_425584 435 1 690 690 CD 10_1101-2021_01_06_425584 435 2 44 44 CD 10_1101-2021_01_06_425584 435 3 . . . 10_1101-2021_01_06_425584 436 1 Widlansky Widlansky NNP 10_1101-2021_01_06_425584 436 2 , , , 10_1101-2021_01_06_425584 436 3 M. M. NNP 10_1101-2021_01_06_425584 436 4 E. E. NNP 10_1101-2021_01_06_425584 436 5 ; ; : 10_1101-2021_01_06_425584 436 6 Gokce Gokce NNP 10_1101-2021_01_06_425584 436 7 , , , 10_1101-2021_01_06_425584 436 8 N. N. NNP 10_1101-2021_01_06_425584 436 9 ; ; : 10_1101-2021_01_06_425584 436 10 Keaney Keaney NNP 10_1101-2021_01_06_425584 436 11 , , , 10_1101-2021_01_06_425584 436 12 J. J. NNP 10_1101-2021_01_06_425584 436 13 F. F. NNP 10_1101-2021_01_06_425584 436 14 , , , 10_1101-2021_01_06_425584 436 15 Jr. Jr. NNP 10_1101-2021_01_06_425584 436 16 ; ; : 10_1101-2021_01_06_425584 436 17 Vita Vita NNP 10_1101-2021_01_06_425584 436 18 , , , 10_1101-2021_01_06_425584 436 19 J. J. NNP 10_1101-2021_01_06_425584 437 1 A. A. NNP 10_1101-2021_01_06_425584 437 2 , , , 10_1101-2021_01_06_425584 437 3 The the DT 10_1101-2021_01_06_425584 437 4 clinical clinical JJ 10_1101-2021_01_06_425584 437 5 implications implication NNS 10_1101-2021_01_06_425584 437 6 of of IN 10_1101-2021_01_06_425584 437 7 691 691 CD 10_1101-2021_01_06_425584 437 8 endothelial endothelial JJ 10_1101-2021_01_06_425584 437 9 dysfunction dysfunction NN 10_1101-2021_01_06_425584 437 10 . . . 10_1101-2021_01_06_425584 438 1 J J NNP 10_1101-2021_01_06_425584 438 2 Am Am NNP 10_1101-2021_01_06_425584 438 3 Coll Coll NNP 10_1101-2021_01_06_425584 438 4 Cardiol Cardiol NNP 10_1101-2021_01_06_425584 438 5 2003 2003 CD 10_1101-2021_01_06_425584 438 6 , , , 10_1101-2021_01_06_425584 438 7 42 42 CD 10_1101-2021_01_06_425584 438 8 , , , 10_1101-2021_01_06_425584 438 9 ( ( -LRB- 10_1101-2021_01_06_425584 438 10 7 7 CD 10_1101-2021_01_06_425584 438 11 ) ) -RRB- 10_1101-2021_01_06_425584 438 12 , , , 10_1101-2021_01_06_425584 438 13 1149 1149 CD 10_1101-2021_01_06_425584 438 14 - - SYM 10_1101-2021_01_06_425584 438 15 60 60 CD 10_1101-2021_01_06_425584 438 16 . . . 10_1101-2021_01_06_425584 439 1 692 692 CD 10_1101-2021_01_06_425584 439 2 45 45 CD 10_1101-2021_01_06_425584 439 3 . . . 10_1101-2021_01_06_425584 440 1 Ganz Ganz NNP 10_1101-2021_01_06_425584 440 2 , , , 10_1101-2021_01_06_425584 440 3 P. P. NNP 10_1101-2021_01_06_425584 440 4 ; ; : 10_1101-2021_01_06_425584 440 5 Vita Vita NNP 10_1101-2021_01_06_425584 440 6 , , , 10_1101-2021_01_06_425584 440 7 J. J. NNP 10_1101-2021_01_06_425584 441 1 A. A. NNP 10_1101-2021_01_06_425584 441 2 , , , 10_1101-2021_01_06_425584 441 3 Testing test VBG 10_1101-2021_01_06_425584 441 4 endothelial endothelial JJ 10_1101-2021_01_06_425584 441 5 vasomotor vasomotor NN 10_1101-2021_01_06_425584 441 6 function function NN 10_1101-2021_01_06_425584 441 7 : : : 10_1101-2021_01_06_425584 441 8 nitric nitric JJ 10_1101-2021_01_06_425584 441 9 oxide oxide NN 10_1101-2021_01_06_425584 441 10 , , , 10_1101-2021_01_06_425584 441 11 a a DT 10_1101-2021_01_06_425584 441 12 multipotent multipotent NN 10_1101-2021_01_06_425584 441 13 693 693 CD 10_1101-2021_01_06_425584 441 14 molecule molecule NN 10_1101-2021_01_06_425584 441 15 . . . 10_1101-2021_01_06_425584 442 1 Circulation circulation NN 10_1101-2021_01_06_425584 442 2 2003 2003 CD 10_1101-2021_01_06_425584 442 3 , , , 10_1101-2021_01_06_425584 442 4 108 108 CD 10_1101-2021_01_06_425584 442 5 , , , 10_1101-2021_01_06_425584 442 6 ( ( -LRB- 10_1101-2021_01_06_425584 442 7 17 17 CD 10_1101-2021_01_06_425584 442 8 ) ) -RRB- 10_1101-2021_01_06_425584 442 9 , , , 10_1101-2021_01_06_425584 442 10 2049 2049 CD 10_1101-2021_01_06_425584 442 11 - - SYM 10_1101-2021_01_06_425584 442 12 53 53 CD 10_1101-2021_01_06_425584 442 13 . . . 10_1101-2021_01_06_425584 443 1 694 694 CD 10_1101-2021_01_06_425584 443 2 46 46 CD 10_1101-2021_01_06_425584 443 3 . . . 10_1101-2021_01_06_425584 444 1 Paulus Paulus NNP 10_1101-2021_01_06_425584 444 2 , , , 10_1101-2021_01_06_425584 444 3 W. W. NNP 10_1101-2021_01_06_425584 444 4 J. J. NNP 10_1101-2021_01_06_425584 444 5 ; ; : 10_1101-2021_01_06_425584 444 6 Vantrimpont Vantrimpont NNP 10_1101-2021_01_06_425584 444 7 , , , 10_1101-2021_01_06_425584 444 8 P. P. NNP 10_1101-2021_01_06_425584 444 9 J. J. NNP 10_1101-2021_01_06_425584 444 10 ; ; : 10_1101-2021_01_06_425584 444 11 Shah Shah NNP 10_1101-2021_01_06_425584 444 12 , , , 10_1101-2021_01_06_425584 444 13 A. a. NN 10_1101-2021_01_06_425584 444 14 M. M. NNP 10_1101-2021_01_06_425584 444 15 , , , 10_1101-2021_01_06_425584 444 16 Paracrine Paracrine NNP 10_1101-2021_01_06_425584 444 17 coronary coronary JJ 10_1101-2021_01_06_425584 444 18 endothelial endothelial JJ 10_1101-2021_01_06_425584 444 19 control control NN 10_1101-2021_01_06_425584 444 20 of of IN 10_1101-2021_01_06_425584 444 21 695 695 CD 10_1101-2021_01_06_425584 444 22 left left JJ 10_1101-2021_01_06_425584 444 23 ventricular ventricular JJ 10_1101-2021_01_06_425584 444 24 function function NN 10_1101-2021_01_06_425584 444 25 in in IN 10_1101-2021_01_06_425584 444 26 humans human NNS 10_1101-2021_01_06_425584 444 27 . . . 10_1101-2021_01_06_425584 445 1 Circulation circulation NN 10_1101-2021_01_06_425584 445 2 1995 1995 CD 10_1101-2021_01_06_425584 445 3 , , , 10_1101-2021_01_06_425584 445 4 92 92 CD 10_1101-2021_01_06_425584 445 5 , , , 10_1101-2021_01_06_425584 445 6 ( ( -LRB- 10_1101-2021_01_06_425584 445 7 8) 8) CD 10_1101-2021_01_06_425584 445 8 , , , 10_1101-2021_01_06_425584 445 9 2119 2119 CD 10_1101-2021_01_06_425584 445 10 - - SYM 10_1101-2021_01_06_425584 445 11 26 26 CD 10_1101-2021_01_06_425584 445 12 . . . 10_1101-2021_01_06_425584 446 1 696 696 CD 10_1101-2021_01_06_425584 446 2 47 47 CD 10_1101-2021_01_06_425584 446 3 . . . 10_1101-2021_01_06_425584 447 1 Abe Abe NNP 10_1101-2021_01_06_425584 447 2 , , , 10_1101-2021_01_06_425584 447 3 M. M. NNP 10_1101-2021_01_06_425584 447 4 ; ; : 10_1101-2021_01_06_425584 447 5 Ono Ono NNP 10_1101-2021_01_06_425584 447 6 , , , 10_1101-2021_01_06_425584 447 7 J. J. NNP 10_1101-2021_01_06_425584 447 8 ; ; : 10_1101-2021_01_06_425584 447 9 Sato Sato NNP 10_1101-2021_01_06_425584 447 10 , , , 10_1101-2021_01_06_425584 447 11 Y. Y. NNP 10_1101-2021_01_06_425584 447 12 ; ; : 10_1101-2021_01_06_425584 447 13 Okeda Okeda NNP 10_1101-2021_01_06_425584 447 14 , , , 10_1101-2021_01_06_425584 447 15 T. T. NNP 10_1101-2021_01_06_425584 447 16 ; ; : 10_1101-2021_01_06_425584 447 17 Takaki Takaki NNP 10_1101-2021_01_06_425584 447 18 , , , 10_1101-2021_01_06_425584 447 19 R. R. NNP 10_1101-2021_01_06_425584 447 20 , , , 10_1101-2021_01_06_425584 447 21 Effects Effects NNPS 10_1101-2021_01_06_425584 447 22 of of IN 10_1101-2021_01_06_425584 447 23 glucose glucose NN 10_1101-2021_01_06_425584 447 24 and and CC 10_1101-2021_01_06_425584 447 25 insulin insulin NN 10_1101-2021_01_06_425584 447 26 on on IN 10_1101-2021_01_06_425584 447 27 697 697 CD 10_1101-2021_01_06_425584 447 28 cultured cultured JJ 10_1101-2021_01_06_425584 447 29 human human JJ 10_1101-2021_01_06_425584 447 30 microvascular microvascular JJ 10_1101-2021_01_06_425584 447 31 endothelial endothelial JJ 10_1101-2021_01_06_425584 447 32 cells cell NNS 10_1101-2021_01_06_425584 447 33 . . . 10_1101-2021_01_06_425584 448 1 Diabetes diabetes NN 10_1101-2021_01_06_425584 448 2 Res res VBP 10_1101-2021_01_06_425584 448 3 Clin Clin NNP 10_1101-2021_01_06_425584 448 4 Pract Pract NNP 10_1101-2021_01_06_425584 448 5 1990 1990 CD 10_1101-2021_01_06_425584 448 6 , , , 10_1101-2021_01_06_425584 448 7 9 9 CD 10_1101-2021_01_06_425584 448 8 , , , 10_1101-2021_01_06_425584 448 9 ( ( -LRB- 10_1101-2021_01_06_425584 448 10 3 3 CD 10_1101-2021_01_06_425584 448 11 ) ) -RRB- 10_1101-2021_01_06_425584 448 12 , , , 10_1101-2021_01_06_425584 448 13 287 287 CD 10_1101-2021_01_06_425584 448 14 - - SYM 10_1101-2021_01_06_425584 448 15 95 95 CD 10_1101-2021_01_06_425584 448 16 . . . 10_1101-2021_01_06_425584 449 1 698 698 CD 10_1101-2021_01_06_425584 449 2 48 48 CD 10_1101-2021_01_06_425584 449 3 . . . 10_1101-2021_01_06_425584 450 1 Du Du NNP 10_1101-2021_01_06_425584 450 2 , , , 10_1101-2021_01_06_425584 450 3 X. X. NNP 10_1101-2021_01_06_425584 450 4 L. L. NNP 10_1101-2021_01_06_425584 450 5 ; ; : 10_1101-2021_01_06_425584 450 6 Sui Sui NNP 10_1101-2021_01_06_425584 450 7 , , , 10_1101-2021_01_06_425584 450 8 G. G. NNP 10_1101-2021_01_06_425584 450 9 Z. Z. NNP 10_1101-2021_01_06_425584 450 10 ; ; : 10_1101-2021_01_06_425584 450 11 Stockklauser Stockklauser NNP 10_1101-2021_01_06_425584 450 12 - - HYPH 10_1101-2021_01_06_425584 450 13 Farber Farber NNP 10_1101-2021_01_06_425584 450 14 , , , 10_1101-2021_01_06_425584 450 15 K. K. NNP 10_1101-2021_01_06_425584 450 16 ; ; : 10_1101-2021_01_06_425584 450 17 Weiss Weiss NNP 10_1101-2021_01_06_425584 450 18 , , , 10_1101-2021_01_06_425584 450 19 J. J. NNP 10_1101-2021_01_06_425584 450 20 ; ; : 10_1101-2021_01_06_425584 450 21 Zink Zink NNP 10_1101-2021_01_06_425584 450 22 , , , 10_1101-2021_01_06_425584 450 23 S. S. NNP 10_1101-2021_01_06_425584 450 24 ; ; : 10_1101-2021_01_06_425584 450 25 Schwippert Schwippert NNP 10_1101-2021_01_06_425584 450 26 , , , 10_1101-2021_01_06_425584 450 27 B. B. NNP 10_1101-2021_01_06_425584 450 28 ; ; : 10_1101-2021_01_06_425584 450 29 Wu Wu NNP 10_1101-2021_01_06_425584 450 30 , , , 10_1101-2021_01_06_425584 450 31 Q. Q. NNP 10_1101-2021_01_06_425584 451 1 699 699 CD 10_1101-2021_01_06_425584 451 2 X. X. NNP 10_1101-2021_01_06_425584 451 3 ; ; : 10_1101-2021_01_06_425584 451 4 Tschope Tschope NNP 10_1101-2021_01_06_425584 451 5 , , , 10_1101-2021_01_06_425584 451 6 D. D. NNP 10_1101-2021_01_06_425584 451 7 ; ; : 10_1101-2021_01_06_425584 451 8 Rosen Rosen NNP 10_1101-2021_01_06_425584 451 9 , , , 10_1101-2021_01_06_425584 451 10 P. P. NNP 10_1101-2021_01_06_425584 451 11 , , , 10_1101-2021_01_06_425584 451 12 Introduction introduction NN 10_1101-2021_01_06_425584 451 13 of of IN 10_1101-2021_01_06_425584 451 14 apoptosis apoptosis NN 10_1101-2021_01_06_425584 451 15 by by IN 10_1101-2021_01_06_425584 451 16 high high JJ 10_1101-2021_01_06_425584 451 17 proinsulin proinsulin NN 10_1101-2021_01_06_425584 451 18 and and CC 10_1101-2021_01_06_425584 451 19 glucose glucose NN 10_1101-2021_01_06_425584 451 20 in in RP 10_1101-2021_01_06_425584 451 21 cultured cultured JJ 10_1101-2021_01_06_425584 451 22 700 700 CD 10_1101-2021_01_06_425584 451 23 human human JJ 10_1101-2021_01_06_425584 451 24 umbilical umbilical JJ 10_1101-2021_01_06_425584 451 25 vein vein NN 10_1101-2021_01_06_425584 451 26 endothelial endothelial JJ 10_1101-2021_01_06_425584 451 27 cells cell NNS 10_1101-2021_01_06_425584 451 28 is be VBZ 10_1101-2021_01_06_425584 451 29 mediated mediate VBN 10_1101-2021_01_06_425584 451 30 by by IN 10_1101-2021_01_06_425584 451 31 reactive reactive JJ 10_1101-2021_01_06_425584 451 32 oxygen oxygen NN 10_1101-2021_01_06_425584 451 33 species specie NNS 10_1101-2021_01_06_425584 451 34 . . . 10_1101-2021_01_06_425584 452 1 Diabetologia Diabetologia NNP 10_1101-2021_01_06_425584 452 2 701 701 CD 10_1101-2021_01_06_425584 452 3 1998 1998 CD 10_1101-2021_01_06_425584 452 4 , , , 10_1101-2021_01_06_425584 452 5 41 41 CD 10_1101-2021_01_06_425584 452 6 , , , 10_1101-2021_01_06_425584 452 7 ( ( -LRB- 10_1101-2021_01_06_425584 452 8 3 3 CD 10_1101-2021_01_06_425584 452 9 ) ) -RRB- 10_1101-2021_01_06_425584 452 10 , , , 10_1101-2021_01_06_425584 452 11 249 249 CD 10_1101-2021_01_06_425584 452 12 - - SYM 10_1101-2021_01_06_425584 452 13 56 56 CD 10_1101-2021_01_06_425584 452 14 . . . 10_1101-2021_01_06_425584 453 1 702 702 CD 10_1101-2021_01_06_425584 453 2 49 49 CD 10_1101-2021_01_06_425584 453 3 . . . 10_1101-2021_01_06_425584 454 1 Graier Graier NNP 10_1101-2021_01_06_425584 454 2 , , , 10_1101-2021_01_06_425584 454 3 W. W. NNP 10_1101-2021_01_06_425584 454 4 F. F. NNP 10_1101-2021_01_06_425584 454 5 ; ; : 10_1101-2021_01_06_425584 454 6 Grubenthal Grubenthal NNP 10_1101-2021_01_06_425584 454 7 , , , 10_1101-2021_01_06_425584 454 8 I. I. NNP 10_1101-2021_01_06_425584 454 9 ; ; : 10_1101-2021_01_06_425584 454 10 Dittrich Dittrich NNP 10_1101-2021_01_06_425584 454 11 , , , 10_1101-2021_01_06_425584 454 12 P. P. NNP 10_1101-2021_01_06_425584 454 13 ; ; : 10_1101-2021_01_06_425584 454 14 Wascher Wascher NNP 10_1101-2021_01_06_425584 454 15 , , , 10_1101-2021_01_06_425584 454 16 T. T. NNP 10_1101-2021_01_06_425584 454 17 C. C. NNP 10_1101-2021_01_06_425584 454 18 ; ; : 10_1101-2021_01_06_425584 454 19 Kostner Kostner NNP 10_1101-2021_01_06_425584 454 20 , , , 10_1101-2021_01_06_425584 454 21 G. G. NNP 10_1101-2021_01_06_425584 454 22 M. M. NNP 10_1101-2021_01_06_425584 454 23 , , , 10_1101-2021_01_06_425584 454 24 Intracellular Intracellular NNP 10_1101-2021_01_06_425584 454 25 703 703 CD 10_1101-2021_01_06_425584 454 26 mechanism mechanism NN 10_1101-2021_01_06_425584 454 27 of of IN 10_1101-2021_01_06_425584 454 28 high high JJ 10_1101-2021_01_06_425584 454 29 D d NN 10_1101-2021_01_06_425584 454 30 - - HYPH 10_1101-2021_01_06_425584 454 31 glucose glucose NN 10_1101-2021_01_06_425584 454 32 - - HYPH 10_1101-2021_01_06_425584 454 33 induced induce VBN 10_1101-2021_01_06_425584 454 34 modulation modulation NN 10_1101-2021_01_06_425584 454 35 of of IN 10_1101-2021_01_06_425584 454 36 vascular vascular JJ 10_1101-2021_01_06_425584 454 37 cell cell NN 10_1101-2021_01_06_425584 454 38 proliferation proliferation NN 10_1101-2021_01_06_425584 454 39 . . . 10_1101-2021_01_06_425584 455 1 Eur Eur NNP 10_1101-2021_01_06_425584 455 2 J J NNP 10_1101-2021_01_06_425584 455 3 Pharmacol Pharmacol NNP 10_1101-2021_01_06_425584 455 4 704 704 CD 10_1101-2021_01_06_425584 455 5 1995 1995 CD 10_1101-2021_01_06_425584 455 6 , , , 10_1101-2021_01_06_425584 455 7 294 294 CD 10_1101-2021_01_06_425584 455 8 , , , 10_1101-2021_01_06_425584 455 9 ( ( -LRB- 10_1101-2021_01_06_425584 455 10 1 1 CD 10_1101-2021_01_06_425584 455 11 ) ) -RRB- 10_1101-2021_01_06_425584 455 12 , , , 10_1101-2021_01_06_425584 455 13 221 221 CD 10_1101-2021_01_06_425584 455 14 - - SYM 10_1101-2021_01_06_425584 455 15 9 9 CD 10_1101-2021_01_06_425584 455 16 . . . 10_1101-2021_01_06_425584 456 1 705 705 CD 10_1101-2021_01_06_425584 456 2 50 50 CD 10_1101-2021_01_06_425584 456 3 . . . 10_1101-2021_01_06_425584 457 1 Kamal Kamal NNP 10_1101-2021_01_06_425584 457 2 , , , 10_1101-2021_01_06_425584 457 3 K. K. NNP 10_1101-2021_01_06_425584 457 4 ; ; : 10_1101-2021_01_06_425584 457 5 Du Du NNP 10_1101-2021_01_06_425584 457 6 , , , 10_1101-2021_01_06_425584 457 7 W. W. NNP 10_1101-2021_01_06_425584 457 8 ; ; : 10_1101-2021_01_06_425584 457 9 Mills Mills NNP 10_1101-2021_01_06_425584 457 10 , , , 10_1101-2021_01_06_425584 457 11 I. i. NN 10_1101-2021_01_06_425584 457 12 ; ; : 10_1101-2021_01_06_425584 457 13 Sumpio Sumpio NNP 10_1101-2021_01_06_425584 457 14 , , , 10_1101-2021_01_06_425584 457 15 B. B. NNP 10_1101-2021_01_06_425584 457 16 E. E. NNP 10_1101-2021_01_06_425584 457 17 , , , 10_1101-2021_01_06_425584 457 18 Antiproliferative antiproliferative JJ 10_1101-2021_01_06_425584 457 19 effect effect NN 10_1101-2021_01_06_425584 457 20 of of IN 10_1101-2021_01_06_425584 457 21 elevated elevated JJ 10_1101-2021_01_06_425584 457 22 glucose glucose NN 10_1101-2021_01_06_425584 457 23 in in IN 10_1101-2021_01_06_425584 457 24 706 706 CD 10_1101-2021_01_06_425584 457 25 human human JJ 10_1101-2021_01_06_425584 457 26 microvascular microvascular JJ 10_1101-2021_01_06_425584 457 27 endothelial endothelial JJ 10_1101-2021_01_06_425584 457 28 cells cell NNS 10_1101-2021_01_06_425584 457 29 . . . 10_1101-2021_01_06_425584 458 1 J J NNP 10_1101-2021_01_06_425584 458 2 Cell Cell NNP 10_1101-2021_01_06_425584 458 3 Biochem Biochem NNP 10_1101-2021_01_06_425584 458 4 1998 1998 CD 10_1101-2021_01_06_425584 458 5 , , , 10_1101-2021_01_06_425584 458 6 71 71 CD 10_1101-2021_01_06_425584 458 7 , , , 10_1101-2021_01_06_425584 458 8 ( ( -LRB- 10_1101-2021_01_06_425584 458 9 4 4 CD 10_1101-2021_01_06_425584 458 10 ) ) -RRB- 10_1101-2021_01_06_425584 458 11 , , , 10_1101-2021_01_06_425584 458 12 491 491 CD 10_1101-2021_01_06_425584 458 13 - - SYM 10_1101-2021_01_06_425584 458 14 501 501 CD 10_1101-2021_01_06_425584 458 15 . . . 10_1101-2021_01_06_425584 459 1 707 707 CD 10_1101-2021_01_06_425584 459 2 51 51 CD 10_1101-2021_01_06_425584 459 3 . . . 10_1101-2021_01_06_425584 460 1 Lorenzi Lorenzi NNP 10_1101-2021_01_06_425584 460 2 , , , 10_1101-2021_01_06_425584 460 3 M. M. NNP 10_1101-2021_01_06_425584 460 4 ; ; : 10_1101-2021_01_06_425584 460 5 Nordberg Nordberg NNP 10_1101-2021_01_06_425584 460 6 , , , 10_1101-2021_01_06_425584 460 7 J. J. NNP 10_1101-2021_01_06_425584 461 1 A. a. LS 10_1101-2021_01_06_425584 461 2 ; ; : 10_1101-2021_01_06_425584 461 3 Toledo Toledo NNP 10_1101-2021_01_06_425584 461 4 , , , 10_1101-2021_01_06_425584 461 5 S. S. NNP 10_1101-2021_01_06_425584 461 6 , , , 10_1101-2021_01_06_425584 461 7 High High NNP 10_1101-2021_01_06_425584 461 8 glucose glucose NN 10_1101-2021_01_06_425584 461 9 prolongs prolong NNS 10_1101-2021_01_06_425584 461 10 cell cell NN 10_1101-2021_01_06_425584 461 11 - - HYPH 10_1101-2021_01_06_425584 461 12 cycle cycle NN 10_1101-2021_01_06_425584 461 13 traversal traversal NN 10_1101-2021_01_06_425584 461 14 of of IN 10_1101-2021_01_06_425584 461 15 708 708 CD 10_1101-2021_01_06_425584 461 16 cultured cultured JJ 10_1101-2021_01_06_425584 461 17 human human JJ 10_1101-2021_01_06_425584 461 18 endothelial endothelial JJ 10_1101-2021_01_06_425584 461 19 cells cell NNS 10_1101-2021_01_06_425584 461 20 . . . 10_1101-2021_01_06_425584 462 1 Diabetes diabetes NN 10_1101-2021_01_06_425584 462 2 1987 1987 CD 10_1101-2021_01_06_425584 462 3 , , , 10_1101-2021_01_06_425584 462 4 36 36 CD 10_1101-2021_01_06_425584 462 5 , , , 10_1101-2021_01_06_425584 462 6 ( ( -LRB- 10_1101-2021_01_06_425584 462 7 11 11 CD 10_1101-2021_01_06_425584 462 8 ) ) -RRB- 10_1101-2021_01_06_425584 462 9 , , , 10_1101-2021_01_06_425584 462 10 1261 1261 CD 10_1101-2021_01_06_425584 462 11 - - SYM 10_1101-2021_01_06_425584 462 12 7 7 CD 10_1101-2021_01_06_425584 462 13 . . . 10_1101-2021_01_06_425584 463 1 709 709 CD 10_1101-2021_01_06_425584 463 2 52 52 CD 10_1101-2021_01_06_425584 463 3 . . . 10_1101-2021_01_06_425584 464 1 Quagliaro Quagliaro NNP 10_1101-2021_01_06_425584 464 2 , , , 10_1101-2021_01_06_425584 464 3 L. L. NNP 10_1101-2021_01_06_425584 464 4 ; ; : 10_1101-2021_01_06_425584 464 5 Piconi Piconi NNP 10_1101-2021_01_06_425584 464 6 , , , 10_1101-2021_01_06_425584 464 7 L. L. NNP 10_1101-2021_01_06_425584 464 8 ; ; : 10_1101-2021_01_06_425584 464 9 Assaloni Assaloni NNP 10_1101-2021_01_06_425584 464 10 , , , 10_1101-2021_01_06_425584 464 11 R. R. NNP 10_1101-2021_01_06_425584 464 12 ; ; : 10_1101-2021_01_06_425584 464 13 Martinelli Martinelli NNP 10_1101-2021_01_06_425584 464 14 , , , 10_1101-2021_01_06_425584 464 15 L. L. NNP 10_1101-2021_01_06_425584 464 16 ; ; : 10_1101-2021_01_06_425584 464 17 Motz Motz NNP 10_1101-2021_01_06_425584 464 18 , , , 10_1101-2021_01_06_425584 464 19 E. E. NNP 10_1101-2021_01_06_425584 464 20 ; ; : 10_1101-2021_01_06_425584 464 21 Ceriello Ceriello NNP 10_1101-2021_01_06_425584 464 22 , , , 10_1101-2021_01_06_425584 464 23 A. a. NN 10_1101-2021_01_06_425584 464 24 , , , 10_1101-2021_01_06_425584 464 25 Intermittent Intermittent NNP 10_1101-2021_01_06_425584 464 26 710 710 CD 10_1101-2021_01_06_425584 464 27 high high JJ 10_1101-2021_01_06_425584 464 28 glucose glucose NN 10_1101-2021_01_06_425584 464 29 enhances enhance VBZ 10_1101-2021_01_06_425584 464 30 apoptosis apoptosis NN 10_1101-2021_01_06_425584 464 31 related relate VBN 10_1101-2021_01_06_425584 464 32 to to IN 10_1101-2021_01_06_425584 464 33 oxidative oxidative JJ 10_1101-2021_01_06_425584 464 34 stress stress NN 10_1101-2021_01_06_425584 464 35 in in IN 10_1101-2021_01_06_425584 464 36 human human JJ 10_1101-2021_01_06_425584 464 37 umbilical umbilical JJ 10_1101-2021_01_06_425584 464 38 vein vein NN 10_1101-2021_01_06_425584 464 39 endothelial endothelial JJ 10_1101-2021_01_06_425584 464 40 711 711 CD 10_1101-2021_01_06_425584 464 41 cells cell NNS 10_1101-2021_01_06_425584 464 42 : : : 10_1101-2021_01_06_425584 464 43 the the DT 10_1101-2021_01_06_425584 464 44 role role NN 10_1101-2021_01_06_425584 464 45 of of IN 10_1101-2021_01_06_425584 464 46 protein protein NN 10_1101-2021_01_06_425584 464 47 kinase kinase VBD 10_1101-2021_01_06_425584 464 48 C C NNP 10_1101-2021_01_06_425584 464 49 and and CC 10_1101-2021_01_06_425584 464 50 NAD(P)H NAD(P)H NNP 10_1101-2021_01_06_425584 464 51 - - HYPH 10_1101-2021_01_06_425584 464 52 oxidase oxidase NN 10_1101-2021_01_06_425584 464 53 activation activation NN 10_1101-2021_01_06_425584 464 54 . . . 10_1101-2021_01_06_425584 465 1 Diabetes diabetes NN 10_1101-2021_01_06_425584 465 2 2003 2003 CD 10_1101-2021_01_06_425584 465 3 , , , 10_1101-2021_01_06_425584 465 4 52 52 CD 10_1101-2021_01_06_425584 465 5 , , , 10_1101-2021_01_06_425584 465 6 ( ( -LRB- 10_1101-2021_01_06_425584 465 7 11 11 CD 10_1101-2021_01_06_425584 465 8 ) ) -RRB- 10_1101-2021_01_06_425584 465 9 , , , 10_1101-2021_01_06_425584 465 10 712 712 CD 10_1101-2021_01_06_425584 465 11 2795 2795 CD 10_1101-2021_01_06_425584 465 12 - - SYM 10_1101-2021_01_06_425584 465 13 804 804 CD 10_1101-2021_01_06_425584 465 14 . . . 10_1101-2021_01_06_425584 466 1 713 713 CD 10_1101-2021_01_06_425584 466 2 53 53 CD 10_1101-2021_01_06_425584 466 3 . . . 10_1101-2021_01_06_425584 467 1 McGinn McGinn NNP 10_1101-2021_01_06_425584 467 2 , , , 10_1101-2021_01_06_425584 467 3 S. S. NNP 10_1101-2021_01_06_425584 467 4 ; ; : 10_1101-2021_01_06_425584 467 5 Poronnik Poronnik NNP 10_1101-2021_01_06_425584 467 6 , , , 10_1101-2021_01_06_425584 467 7 P. P. NNP 10_1101-2021_01_06_425584 467 8 ; ; : 10_1101-2021_01_06_425584 467 9 King King NNP 10_1101-2021_01_06_425584 467 10 , , , 10_1101-2021_01_06_425584 467 11 M. M. NNP 10_1101-2021_01_06_425584 467 12 ; ; : 10_1101-2021_01_06_425584 467 13 Gallery Gallery NNP 10_1101-2021_01_06_425584 467 14 , , , 10_1101-2021_01_06_425584 467 15 E. E. NNP 10_1101-2021_01_06_425584 467 16 D. D. NNP 10_1101-2021_01_06_425584 467 17 ; ; : 10_1101-2021_01_06_425584 467 18 Pollock Pollock NNP 10_1101-2021_01_06_425584 467 19 , , , 10_1101-2021_01_06_425584 467 20 C. C. NNP 10_1101-2021_01_06_425584 467 21 A. A. NNP 10_1101-2021_01_06_425584 467 22 , , , 10_1101-2021_01_06_425584 467 23 High high JJ 10_1101-2021_01_06_425584 467 24 glucose glucose NN 10_1101-2021_01_06_425584 467 25 and and CC 10_1101-2021_01_06_425584 467 26 714 714 CD 10_1101-2021_01_06_425584 467 27 endothelial endothelial JJ 10_1101-2021_01_06_425584 467 28 cell cell NN 10_1101-2021_01_06_425584 467 29 growth growth NN 10_1101-2021_01_06_425584 467 30 : : : 10_1101-2021_01_06_425584 467 31 novel novel JJ 10_1101-2021_01_06_425584 467 32 effects effect NNS 10_1101-2021_01_06_425584 467 33 independent independent JJ 10_1101-2021_01_06_425584 467 34 of of IN 10_1101-2021_01_06_425584 467 35 autocrine autocrine NN 10_1101-2021_01_06_425584 467 36 TGF TGF NNP 10_1101-2021_01_06_425584 467 37 - - HYPH 10_1101-2021_01_06_425584 467 38 beta beta NNP 10_1101-2021_01_06_425584 467 39 1 1 CD 10_1101-2021_01_06_425584 467 40 and and CC 10_1101-2021_01_06_425584 467 41 hyperosmolarity hyperosmolarity NN 10_1101-2021_01_06_425584 467 42 . . . 10_1101-2021_01_06_425584 468 1 715 715 CD 10_1101-2021_01_06_425584 468 2 Am Am NNP 10_1101-2021_01_06_425584 468 3 J J NNP 10_1101-2021_01_06_425584 468 4 Physiol Physiol NNP 10_1101-2021_01_06_425584 468 5 Cell Cell NNP 10_1101-2021_01_06_425584 468 6 Physiol Physiol NNP 10_1101-2021_01_06_425584 468 7 2003 2003 CD 10_1101-2021_01_06_425584 468 8 , , , 10_1101-2021_01_06_425584 468 9 284 284 CD 10_1101-2021_01_06_425584 468 10 , , , 10_1101-2021_01_06_425584 468 11 ( ( -LRB- 10_1101-2021_01_06_425584 468 12 6 6 CD 10_1101-2021_01_06_425584 468 13 ) ) -RRB- 10_1101-2021_01_06_425584 468 14 , , , 10_1101-2021_01_06_425584 468 15 C1374 C1374 NNP 10_1101-2021_01_06_425584 468 16 - - HYPH 10_1101-2021_01_06_425584 468 17 86 86 CD 10_1101-2021_01_06_425584 468 18 . . . 10_1101-2021_01_06_425584 469 1 716 716 CD 10_1101-2021_01_06_425584 469 2 54 54 CD 10_1101-2021_01_06_425584 469 3 . . . 10_1101-2021_01_06_425584 470 1 Yuan Yuan NNP 10_1101-2021_01_06_425584 470 2 , , , 10_1101-2021_01_06_425584 470 3 W. W. NNP 10_1101-2021_01_06_425584 470 4 ; ; : 10_1101-2021_01_06_425584 470 5 Zhang Zhang NNP 10_1101-2021_01_06_425584 470 6 , , , 10_1101-2021_01_06_425584 470 7 J. J. NNP 10_1101-2021_01_06_425584 470 8 ; ; : 10_1101-2021_01_06_425584 470 9 Li Li NNP 10_1101-2021_01_06_425584 470 10 , , , 10_1101-2021_01_06_425584 470 11 S. S. NNP 10_1101-2021_01_06_425584 470 12 ; ; : 10_1101-2021_01_06_425584 470 13 Edwards Edwards NNP 10_1101-2021_01_06_425584 470 14 , , , 10_1101-2021_01_06_425584 470 15 J. J. NNP 10_1101-2021_01_06_425584 470 16 L. L. NNP 10_1101-2021_01_06_425584 470 17 , , , 10_1101-2021_01_06_425584 470 18 Amine Amine NNP 10_1101-2021_01_06_425584 470 19 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 470 20 of of IN 10_1101-2021_01_06_425584 470 21 hyperglycemic hyperglycemic JJ 10_1101-2021_01_06_425584 470 22 717 717 CD 10_1101-2021_01_06_425584 470 23 endothelial endothelial JJ 10_1101-2021_01_06_425584 470 24 cells cell NNS 10_1101-2021_01_06_425584 470 25 using use VBG 10_1101-2021_01_06_425584 470 26 capillary capillary JJ 10_1101-2021_01_06_425584 470 27 LC LC NNP 10_1101-2021_01_06_425584 470 28 - - HYPH 10_1101-2021_01_06_425584 470 29 MS MS NNP 10_1101-2021_01_06_425584 470 30 with with IN 10_1101-2021_01_06_425584 470 31 isobaric isobaric JJ 10_1101-2021_01_06_425584 470 32 tagging tagging NN 10_1101-2021_01_06_425584 470 33 . . . 10_1101-2021_01_06_425584 471 1 J J NNP 10_1101-2021_01_06_425584 471 2 Proteome Proteome NNP 10_1101-2021_01_06_425584 471 3 Res Res NNP 10_1101-2021_01_06_425584 471 4 2011 2011 CD 10_1101-2021_01_06_425584 471 5 , , , 10_1101-2021_01_06_425584 471 6 10 10 CD 10_1101-2021_01_06_425584 471 7 , , , 10_1101-2021_01_06_425584 471 8 ( ( -LRB- 10_1101-2021_01_06_425584 471 9 11 11 CD 10_1101-2021_01_06_425584 471 10 ) ) -RRB- 10_1101-2021_01_06_425584 471 11 , , , 10_1101-2021_01_06_425584 471 12 718 718 CD 10_1101-2021_01_06_425584 471 13 5242 5242 CD 10_1101-2021_01_06_425584 471 14 - - SYM 10_1101-2021_01_06_425584 471 15 50 50 CD 10_1101-2021_01_06_425584 471 16 . . . 10_1101-2021_01_06_425584 472 1 719 719 CD 10_1101-2021_01_06_425584 472 2 55 55 CD 10_1101-2021_01_06_425584 472 3 . . . 10_1101-2021_01_06_425584 473 1 Chen Chen NNP 10_1101-2021_01_06_425584 473 2 , , , 10_1101-2021_01_06_425584 473 3 S. S. NNP 10_1101-2021_01_06_425584 473 4 ; ; : 10_1101-2021_01_06_425584 473 5 Akter Akter NNP 10_1101-2021_01_06_425584 473 6 , , , 10_1101-2021_01_06_425584 473 7 S. S. NNP 10_1101-2021_01_06_425584 473 8 ; ; : 10_1101-2021_01_06_425584 473 9 Kuwahara Kuwahara NNP 10_1101-2021_01_06_425584 473 10 , , , 10_1101-2021_01_06_425584 473 11 K. K. NNP 10_1101-2021_01_06_425584 473 12 ; ; : 10_1101-2021_01_06_425584 473 13 Matsushita Matsushita NNP 10_1101-2021_01_06_425584 473 14 , , , 10_1101-2021_01_06_425584 473 15 Y. Y. NNP 10_1101-2021_01_06_425584 473 16 ; ; : 10_1101-2021_01_06_425584 473 17 Nakagawa Nakagawa NNP 10_1101-2021_01_06_425584 473 18 , , , 10_1101-2021_01_06_425584 473 19 T. T. NNP 10_1101-2021_01_06_425584 473 20 ; ; : 10_1101-2021_01_06_425584 473 21 Konishi Konishi NNP 10_1101-2021_01_06_425584 473 22 , , , 10_1101-2021_01_06_425584 473 23 M. M. NNP 10_1101-2021_01_06_425584 473 24 ; ; : 10_1101-2021_01_06_425584 473 25 Honda Honda NNP 10_1101-2021_01_06_425584 473 26 , , , 10_1101-2021_01_06_425584 473 27 T. t. NN 10_1101-2021_01_06_425584 473 28 ; ; : 10_1101-2021_01_06_425584 473 29 720 720 CD 10_1101-2021_01_06_425584 473 30 Yamamoto Yamamoto NNP 10_1101-2021_01_06_425584 473 31 , , , 10_1101-2021_01_06_425584 473 32 S. S. NNP 10_1101-2021_01_06_425584 473 33 ; ; : 10_1101-2021_01_06_425584 473 34 Hayashi Hayashi NNP 10_1101-2021_01_06_425584 473 35 , , , 10_1101-2021_01_06_425584 473 36 T. T. NNP 10_1101-2021_01_06_425584 473 37 ; ; : 10_1101-2021_01_06_425584 473 38 Noda Noda NNP 10_1101-2021_01_06_425584 473 39 , , , 10_1101-2021_01_06_425584 473 40 M. M. NNP 10_1101-2021_01_06_425584 473 41 ; ; : 10_1101-2021_01_06_425584 473 42 Mizoue Mizoue NNP 10_1101-2021_01_06_425584 473 43 , , , 10_1101-2021_01_06_425584 473 44 T. T. NNP 10_1101-2021_01_06_425584 473 45 , , , 10_1101-2021_01_06_425584 473 46 Serum Serum NNP 10_1101-2021_01_06_425584 473 47 amino amino NN 10_1101-2021_01_06_425584 473 48 acid acid NN 10_1101-2021_01_06_425584 473 49 profiles profile NNS 10_1101-2021_01_06_425584 473 50 and and CC 10_1101-2021_01_06_425584 473 51 risk risk NN 10_1101-2021_01_06_425584 473 52 of of IN 10_1101-2021_01_06_425584 473 53 type type NN 10_1101-2021_01_06_425584 473 54 2 2 CD 10_1101-2021_01_06_425584 473 55 721 721 CD 10_1101-2021_01_06_425584 473 56 diabetes diabete NNS 10_1101-2021_01_06_425584 473 57 among among IN 10_1101-2021_01_06_425584 473 58 Japanese japanese JJ 10_1101-2021_01_06_425584 473 59 adults adult NNS 10_1101-2021_01_06_425584 473 60 in in IN 10_1101-2021_01_06_425584 473 61 the the DT 10_1101-2021_01_06_425584 473 62 Hitachi Hitachi NNP 10_1101-2021_01_06_425584 473 63 Health Health NNP 10_1101-2021_01_06_425584 473 64 Study Study NNP 10_1101-2021_01_06_425584 473 65 . . . 10_1101-2021_01_06_425584 474 1 Sci Sci NNP 10_1101-2021_01_06_425584 474 2 Rep Rep NNP 10_1101-2021_01_06_425584 474 3 2019 2019 CD 10_1101-2021_01_06_425584 474 4 , , , 10_1101-2021_01_06_425584 474 5 9 9 CD 10_1101-2021_01_06_425584 474 6 , , , 10_1101-2021_01_06_425584 474 7 ( ( -LRB- 10_1101-2021_01_06_425584 474 8 1 1 CD 10_1101-2021_01_06_425584 474 9 ) ) -RRB- 10_1101-2021_01_06_425584 474 10 , , , 10_1101-2021_01_06_425584 474 11 7010 7010 CD 10_1101-2021_01_06_425584 474 12 . . . 10_1101-2021_01_06_425584 475 1 722 722 CD 10_1101-2021_01_06_425584 475 2 56 56 CD 10_1101-2021_01_06_425584 475 3 . . . 10_1101-2021_01_06_425584 476 1 Lai Lai NNP 10_1101-2021_01_06_425584 476 2 , , , 10_1101-2021_01_06_425584 476 3 M. M. NNP 10_1101-2021_01_06_425584 476 4 ; ; : 10_1101-2021_01_06_425584 476 5 Liu Liu NNP 10_1101-2021_01_06_425584 476 6 , , , 10_1101-2021_01_06_425584 476 7 Y. Y. NNP 10_1101-2021_01_06_425584 476 8 ; ; : 10_1101-2021_01_06_425584 476 9 Ronnett Ronnett NNP 10_1101-2021_01_06_425584 476 10 , , , 10_1101-2021_01_06_425584 476 11 G. G. NNP 10_1101-2021_01_06_425584 476 12 V. V. NNP 10_1101-2021_01_06_425584 476 13 ; ; : 10_1101-2021_01_06_425584 476 14 Wu Wu NNP 10_1101-2021_01_06_425584 476 15 , , , 10_1101-2021_01_06_425584 476 16 A. a. NN 10_1101-2021_01_06_425584 476 17 ; ; : 10_1101-2021_01_06_425584 476 18 Cox Cox NNP 10_1101-2021_01_06_425584 476 19 , , , 10_1101-2021_01_06_425584 476 20 B. B. NNP 10_1101-2021_01_06_425584 476 21 J. J. NNP 10_1101-2021_01_06_425584 476 22 ; ; : 10_1101-2021_01_06_425584 476 23 Dai Dai NNP 10_1101-2021_01_06_425584 476 24 , , , 10_1101-2021_01_06_425584 476 25 F. F. NNP 10_1101-2021_01_06_425584 476 26 F. F. NNP 10_1101-2021_01_06_425584 476 27 ; ; : 10_1101-2021_01_06_425584 476 28 Rost Rost NNP 10_1101-2021_01_06_425584 476 29 , , , 10_1101-2021_01_06_425584 476 30 H. H. NNP 10_1101-2021_01_06_425584 476 31 L. L. NNP 10_1101-2021_01_06_425584 476 32 ; ; : 10_1101-2021_01_06_425584 476 33 Gunderson Gunderson NNP 10_1101-2021_01_06_425584 476 34 , , , 10_1101-2021_01_06_425584 476 35 E. E. NNP 10_1101-2021_01_06_425584 476 36 723 723 CD 10_1101-2021_01_06_425584 476 37 P. P. NNP 10_1101-2021_01_06_425584 476 38 ; ; : 10_1101-2021_01_06_425584 476 39 Wheeler Wheeler NNP 10_1101-2021_01_06_425584 476 40 , , , 10_1101-2021_01_06_425584 476 41 M. M. NNP 10_1101-2021_01_06_425584 476 42 B. B. NNP 10_1101-2021_01_06_425584 476 43 , , , 10_1101-2021_01_06_425584 476 44 Amino Amino NNP 10_1101-2021_01_06_425584 476 45 acid acid NN 10_1101-2021_01_06_425584 476 46 and and CC 10_1101-2021_01_06_425584 476 47 lipid lipid NN 10_1101-2021_01_06_425584 476 48 metabolism metabolism NN 10_1101-2021_01_06_425584 476 49 in in IN 10_1101-2021_01_06_425584 476 50 post post JJ 10_1101-2021_01_06_425584 476 51 - - JJ 10_1101-2021_01_06_425584 476 52 gestational gestational JJ 10_1101-2021_01_06_425584 476 53 diabetes diabetes NN 10_1101-2021_01_06_425584 476 54 and and CC 10_1101-2021_01_06_425584 476 55 724 724 CD 10_1101-2021_01_06_425584 476 56 progression progression NN 10_1101-2021_01_06_425584 476 57 to to TO 10_1101-2021_01_06_425584 476 58 type type VB 10_1101-2021_01_06_425584 476 59 2 2 CD 10_1101-2021_01_06_425584 476 60 diabetes diabetes NN 10_1101-2021_01_06_425584 476 61 : : : 10_1101-2021_01_06_425584 476 62 A a DT 10_1101-2021_01_06_425584 476 63 metabolic metabolic JJ 10_1101-2021_01_06_425584 476 64 profiling profiling NN 10_1101-2021_01_06_425584 476 65 study study NN 10_1101-2021_01_06_425584 476 66 . . . 10_1101-2021_01_06_425584 477 1 PLoS plos ADD 10_1101-2021_01_06_425584 477 2 Med Med NNP 10_1101-2021_01_06_425584 477 3 2020 2020 CD 10_1101-2021_01_06_425584 477 4 , , , 10_1101-2021_01_06_425584 477 5 17 17 CD 10_1101-2021_01_06_425584 477 6 , , , 10_1101-2021_01_06_425584 477 7 ( ( -LRB- 10_1101-2021_01_06_425584 477 8 5 5 CD 10_1101-2021_01_06_425584 477 9 ) ) -RRB- 10_1101-2021_01_06_425584 477 10 , , , 10_1101-2021_01_06_425584 477 11 e1003112 e1003112 NN 10_1101-2021_01_06_425584 477 12 . . . 10_1101-2021_01_06_425584 478 1 725 725 CD 10_1101-2021_01_06_425584 478 2 .CC .CC : 10_1101-2021_01_06_425584 478 3 - - HYPH 10_1101-2021_01_06_425584 478 4 BY by IN 10_1101-2021_01_06_425584 478 5 - - HYPH 10_1101-2021_01_06_425584 478 6 NC NC NNP 10_1101-2021_01_06_425584 478 7 - - HYPH 10_1101-2021_01_06_425584 478 8 ND ND NNP 10_1101-2021_01_06_425584 478 9 4.0 4.0 CD 10_1101-2021_01_06_425584 478 10 International International NNP 10_1101-2021_01_06_425584 478 11 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 478 12 under under IN 10_1101-2021_01_06_425584 478 13 a a DT 10_1101-2021_01_06_425584 478 14 ( ( -LRB- 10_1101-2021_01_06_425584 478 15 which which WDT 10_1101-2021_01_06_425584 478 16 was be VBD 10_1101-2021_01_06_425584 478 17 not not RB 10_1101-2021_01_06_425584 478 18 certified certify VBN 10_1101-2021_01_06_425584 478 19 by by IN 10_1101-2021_01_06_425584 478 20 peer peer NN 10_1101-2021_01_06_425584 478 21 review review NN 10_1101-2021_01_06_425584 478 22 ) ) -RRB- 10_1101-2021_01_06_425584 478 23 is be VBZ 10_1101-2021_01_06_425584 478 24 the the DT 10_1101-2021_01_06_425584 478 25 author author NN 10_1101-2021_01_06_425584 478 26 / / SYM 10_1101-2021_01_06_425584 478 27 funder funder NN 10_1101-2021_01_06_425584 478 28 , , , 10_1101-2021_01_06_425584 478 29 who who WP 10_1101-2021_01_06_425584 478 30 has have VBZ 10_1101-2021_01_06_425584 478 31 granted grant VBN 10_1101-2021_01_06_425584 478 32 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 478 33 a a DT 10_1101-2021_01_06_425584 478 34 license license NN 10_1101-2021_01_06_425584 478 35 to to TO 10_1101-2021_01_06_425584 478 36 display display VB 10_1101-2021_01_06_425584 478 37 the the DT 10_1101-2021_01_06_425584 478 38 preprint preprint NN 10_1101-2021_01_06_425584 478 39 in in IN 10_1101-2021_01_06_425584 478 40 perpetuity perpetuity NN 10_1101-2021_01_06_425584 478 41 . . . 10_1101-2021_01_06_425584 479 1 It -PRON- PRP 10_1101-2021_01_06_425584 479 2 is be VBZ 10_1101-2021_01_06_425584 479 3 made make VBN 10_1101-2021_01_06_425584 479 4 The the DT 10_1101-2021_01_06_425584 479 5 copyright copyright NN 10_1101-2021_01_06_425584 479 6 holder holder NN 10_1101-2021_01_06_425584 479 7 for for IN 10_1101-2021_01_06_425584 479 8 this this DT 10_1101-2021_01_06_425584 479 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 479 10 version version NN 10_1101-2021_01_06_425584 479 11 posted post VBD 10_1101-2021_01_06_425584 479 12 January January NNP 10_1101-2021_01_06_425584 479 13 8 8 CD 10_1101-2021_01_06_425584 479 14 , , , 10_1101-2021_01_06_425584 479 15 2021 2021 CD 10_1101-2021_01_06_425584 479 16 . . . 10_1101-2021_01_06_425584 479 17 ; ; : 10_1101-2021_01_06_425584 479 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 479 19 : : : 10_1101-2021_01_06_425584 479 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 479 21 preprint preprint NN 10_1101-2021_01_06_425584 479 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 479 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 479 24 25 25 CD 10_1101-2021_01_06_425584 479 25 57 57 CD 10_1101-2021_01_06_425584 479 26 . . . 10_1101-2021_01_06_425584 480 1 Lu Lu NNP 10_1101-2021_01_06_425584 480 2 , , , 10_1101-2021_01_06_425584 480 3 Y. Y. NNP 10_1101-2021_01_06_425584 480 4 ; ; : 10_1101-2021_01_06_425584 480 5 Wang Wang NNP 10_1101-2021_01_06_425584 480 6 , , , 10_1101-2021_01_06_425584 480 7 Y. Y. NNP 10_1101-2021_01_06_425584 480 8 ; ; : 10_1101-2021_01_06_425584 480 9 Liang Liang NNP 10_1101-2021_01_06_425584 480 10 , , , 10_1101-2021_01_06_425584 480 11 X. X. NNP 10_1101-2021_01_06_425584 480 12 ; ; : 10_1101-2021_01_06_425584 480 13 Zou Zou NNP 10_1101-2021_01_06_425584 480 14 , , , 10_1101-2021_01_06_425584 480 15 L. L. NNP 10_1101-2021_01_06_425584 480 16 ; ; : 10_1101-2021_01_06_425584 480 17 Ong Ong NNP 10_1101-2021_01_06_425584 480 18 , , , 10_1101-2021_01_06_425584 480 19 C. C. NNP 10_1101-2021_01_06_425584 480 20 N. N. NNP 10_1101-2021_01_06_425584 480 21 ; ; : 10_1101-2021_01_06_425584 480 22 Yuan Yuan NNP 10_1101-2021_01_06_425584 480 23 , , , 10_1101-2021_01_06_425584 480 24 J. J. NNP 10_1101-2021_01_06_425584 480 25 M. M. NNP 10_1101-2021_01_06_425584 480 26 ; ; : 10_1101-2021_01_06_425584 480 27 Koh Koh NNP 10_1101-2021_01_06_425584 480 28 , , , 10_1101-2021_01_06_425584 480 29 W. W. NNP 10_1101-2021_01_06_425584 480 30 P. P. NNP 10_1101-2021_01_06_425584 480 31 ; ; : 10_1101-2021_01_06_425584 480 32 Pan Pan NNP 10_1101-2021_01_06_425584 480 33 , , , 10_1101-2021_01_06_425584 480 34 A. a. NN 10_1101-2021_01_06_425584 480 35 , , , 10_1101-2021_01_06_425584 480 36 Serum Serum NNP 10_1101-2021_01_06_425584 480 37 726 726 CD 10_1101-2021_01_06_425584 480 38 Amino Amino NNP 10_1101-2021_01_06_425584 480 39 Acids Acids NNPS 10_1101-2021_01_06_425584 480 40 in in IN 10_1101-2021_01_06_425584 480 41 Association Association NNP 10_1101-2021_01_06_425584 480 42 with with IN 10_1101-2021_01_06_425584 480 43 Prevalent Prevalent NNP 10_1101-2021_01_06_425584 480 44 and and CC 10_1101-2021_01_06_425584 480 45 Incident Incident NNP 10_1101-2021_01_06_425584 480 46 Type Type NNP 10_1101-2021_01_06_425584 480 47 2 2 CD 10_1101-2021_01_06_425584 480 48 Diabetes diabetes NN 10_1101-2021_01_06_425584 480 49 in in IN 10_1101-2021_01_06_425584 480 50 A a DT 10_1101-2021_01_06_425584 480 51 Chinese chinese JJ 10_1101-2021_01_06_425584 480 52 727 727 CD 10_1101-2021_01_06_425584 480 53 Population population NN 10_1101-2021_01_06_425584 480 54 . . . 10_1101-2021_01_06_425584 481 1 Metabolites metabolite NNS 10_1101-2021_01_06_425584 481 2 2019 2019 CD 10_1101-2021_01_06_425584 481 3 , , , 10_1101-2021_01_06_425584 481 4 9 9 CD 10_1101-2021_01_06_425584 481 5 , , , 10_1101-2021_01_06_425584 481 6 ( ( -LRB- 10_1101-2021_01_06_425584 481 7 1 1 CD 10_1101-2021_01_06_425584 481 8 ) ) -RRB- 10_1101-2021_01_06_425584 481 9 . . . 10_1101-2021_01_06_425584 482 1 728 728 CD 10_1101-2021_01_06_425584 482 2 58 58 CD 10_1101-2021_01_06_425584 482 3 . . . 10_1101-2021_01_06_425584 483 1 Menni Menni NNP 10_1101-2021_01_06_425584 483 2 , , , 10_1101-2021_01_06_425584 483 3 C. C. NNP 10_1101-2021_01_06_425584 483 4 ; ; : 10_1101-2021_01_06_425584 483 5 Fauman Fauman NNP 10_1101-2021_01_06_425584 483 6 , , , 10_1101-2021_01_06_425584 483 7 E. E. NNP 10_1101-2021_01_06_425584 483 8 ; ; : 10_1101-2021_01_06_425584 483 9 Erte Erte NNP 10_1101-2021_01_06_425584 483 10 , , , 10_1101-2021_01_06_425584 483 11 I. i. NN 10_1101-2021_01_06_425584 483 12 ; ; : 10_1101-2021_01_06_425584 483 13 Perry Perry NNP 10_1101-2021_01_06_425584 483 14 , , , 10_1101-2021_01_06_425584 483 15 J. J. NNP 10_1101-2021_01_06_425584 483 16 R. R. NNP 10_1101-2021_01_06_425584 483 17 ; ; : 10_1101-2021_01_06_425584 483 18 Kastenmuller Kastenmuller NNP 10_1101-2021_01_06_425584 483 19 , , , 10_1101-2021_01_06_425584 483 20 G. G. NNP 10_1101-2021_01_06_425584 483 21 ; ; : 10_1101-2021_01_06_425584 483 22 Shin Shin NNP 10_1101-2021_01_06_425584 483 23 , , , 10_1101-2021_01_06_425584 483 24 S. S. NNP 10_1101-2021_01_06_425584 483 25 Y. Y. NNP 10_1101-2021_01_06_425584 483 26 ; ; : 10_1101-2021_01_06_425584 483 27 Petersen Petersen NNP 10_1101-2021_01_06_425584 483 28 , , , 10_1101-2021_01_06_425584 483 29 A. a. NN 10_1101-2021_01_06_425584 484 1 729 729 CD 10_1101-2021_01_06_425584 484 2 K. K. NNP 10_1101-2021_01_06_425584 484 3 ; ; : 10_1101-2021_01_06_425584 484 4 Hyde Hyde NNP 10_1101-2021_01_06_425584 484 5 , , , 10_1101-2021_01_06_425584 484 6 C. C. NNP 10_1101-2021_01_06_425584 484 7 ; ; : 10_1101-2021_01_06_425584 484 8 Psatha Psatha NNP 10_1101-2021_01_06_425584 484 9 , , , 10_1101-2021_01_06_425584 484 10 M. M. NNP 10_1101-2021_01_06_425584 484 11 ; ; : 10_1101-2021_01_06_425584 484 12 Ward Ward NNP 10_1101-2021_01_06_425584 484 13 , , , 10_1101-2021_01_06_425584 484 14 K. K. NNP 10_1101-2021_01_06_425584 484 15 J. J. NNP 10_1101-2021_01_06_425584 484 16 ; ; : 10_1101-2021_01_06_425584 484 17 Yuan Yuan NNP 10_1101-2021_01_06_425584 484 18 , , , 10_1101-2021_01_06_425584 484 19 W. W. NNP 10_1101-2021_01_06_425584 484 20 ; ; : 10_1101-2021_01_06_425584 484 21 Milburn Milburn NNP 10_1101-2021_01_06_425584 484 22 , , , 10_1101-2021_01_06_425584 484 23 M. M. NNP 10_1101-2021_01_06_425584 484 24 ; ; : 10_1101-2021_01_06_425584 484 25 Palmer Palmer NNP 10_1101-2021_01_06_425584 484 26 , , , 10_1101-2021_01_06_425584 484 27 C. C. NNP 10_1101-2021_01_06_425584 484 28 N. N. NNP 10_1101-2021_01_06_425584 484 29 ; ; : 10_1101-2021_01_06_425584 484 30 Frayling frayling NN 10_1101-2021_01_06_425584 484 31 , , , 10_1101-2021_01_06_425584 484 32 T. T. NNP 10_1101-2021_01_06_425584 484 33 M. M. NNP 10_1101-2021_01_06_425584 484 34 ; ; : 10_1101-2021_01_06_425584 484 35 730 730 CD 10_1101-2021_01_06_425584 484 36 Trimmer Trimmer NNP 10_1101-2021_01_06_425584 484 37 , , , 10_1101-2021_01_06_425584 484 38 J. J. NNP 10_1101-2021_01_06_425584 484 39 ; ; : 10_1101-2021_01_06_425584 484 40 Bell Bell NNP 10_1101-2021_01_06_425584 484 41 , , , 10_1101-2021_01_06_425584 484 42 J. J. NNP 10_1101-2021_01_06_425584 484 43 T. T. NNP 10_1101-2021_01_06_425584 484 44 ; ; : 10_1101-2021_01_06_425584 484 45 Gieger Gieger NNP 10_1101-2021_01_06_425584 484 46 , , , 10_1101-2021_01_06_425584 484 47 C. C. NNP 10_1101-2021_01_06_425584 484 48 ; ; : 10_1101-2021_01_06_425584 484 49 Mohney Mohney NNP 10_1101-2021_01_06_425584 484 50 , , , 10_1101-2021_01_06_425584 484 51 R. R. NNP 10_1101-2021_01_06_425584 484 52 P. P. NNP 10_1101-2021_01_06_425584 484 53 ; ; : 10_1101-2021_01_06_425584 484 54 Brosnan Brosnan NNP 10_1101-2021_01_06_425584 484 55 , , , 10_1101-2021_01_06_425584 484 56 M. M. NNP 10_1101-2021_01_06_425584 484 57 J. J. NNP 10_1101-2021_01_06_425584 484 58 ; ; : 10_1101-2021_01_06_425584 484 59 Suhre Suhre NNP 10_1101-2021_01_06_425584 484 60 , , , 10_1101-2021_01_06_425584 484 61 K. K. NNP 10_1101-2021_01_06_425584 484 62 ; ; : 10_1101-2021_01_06_425584 484 63 Soranzo Soranzo NNP 10_1101-2021_01_06_425584 484 64 , , , 10_1101-2021_01_06_425584 484 65 N. N. NNP 10_1101-2021_01_06_425584 484 66 ; ; : 10_1101-2021_01_06_425584 484 67 731 731 CD 10_1101-2021_01_06_425584 484 68 Spector Spector NNP 10_1101-2021_01_06_425584 484 69 , , , 10_1101-2021_01_06_425584 484 70 T. T. NNP 10_1101-2021_01_06_425584 484 71 D. D. NNP 10_1101-2021_01_06_425584 484 72 , , , 10_1101-2021_01_06_425584 484 73 Biomarkers Biomarkers NNP 10_1101-2021_01_06_425584 484 74 for for IN 10_1101-2021_01_06_425584 484 75 type type NN 10_1101-2021_01_06_425584 484 76 2 2 CD 10_1101-2021_01_06_425584 484 77 diabetes diabetes NN 10_1101-2021_01_06_425584 484 78 and and CC 10_1101-2021_01_06_425584 484 79 impaired impair VBN 10_1101-2021_01_06_425584 484 80 fasting fasting NN 10_1101-2021_01_06_425584 484 81 glucose glucose NN 10_1101-2021_01_06_425584 484 82 using use VBG 10_1101-2021_01_06_425584 484 83 a a DT 10_1101-2021_01_06_425584 484 84 nontargeted nontargete VBN 10_1101-2021_01_06_425584 484 85 732 732 CD 10_1101-2021_01_06_425584 484 86 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 484 87 approach approach NN 10_1101-2021_01_06_425584 484 88 . . . 10_1101-2021_01_06_425584 485 1 Diabetes diabetes NN 10_1101-2021_01_06_425584 485 2 2013 2013 CD 10_1101-2021_01_06_425584 485 3 , , , 10_1101-2021_01_06_425584 485 4 62 62 CD 10_1101-2021_01_06_425584 485 5 , , , 10_1101-2021_01_06_425584 485 6 ( ( -LRB- 10_1101-2021_01_06_425584 485 7 12 12 CD 10_1101-2021_01_06_425584 485 8 ) ) -RRB- 10_1101-2021_01_06_425584 485 9 , , , 10_1101-2021_01_06_425584 485 10 4270 4270 CD 10_1101-2021_01_06_425584 485 11 - - SYM 10_1101-2021_01_06_425584 485 12 6 6 CD 10_1101-2021_01_06_425584 485 13 . . . 10_1101-2021_01_06_425584 486 1 733 733 CD 10_1101-2021_01_06_425584 486 2 59 59 CD 10_1101-2021_01_06_425584 486 3 . . . 10_1101-2021_01_06_425584 487 1 Wang Wang NNP 10_1101-2021_01_06_425584 487 2 , , , 10_1101-2021_01_06_425584 487 3 T. T. NNP 10_1101-2021_01_06_425584 487 4 J. J. NNP 10_1101-2021_01_06_425584 487 5 ; ; : 10_1101-2021_01_06_425584 487 6 Larson Larson NNP 10_1101-2021_01_06_425584 487 7 , , , 10_1101-2021_01_06_425584 487 8 M. M. NNP 10_1101-2021_01_06_425584 487 9 G. G. NNP 10_1101-2021_01_06_425584 487 10 ; ; : 10_1101-2021_01_06_425584 487 11 Vasan Vasan NNP 10_1101-2021_01_06_425584 487 12 , , , 10_1101-2021_01_06_425584 487 13 R. R. NNP 10_1101-2021_01_06_425584 487 14 S. S. NNP 10_1101-2021_01_06_425584 487 15 ; ; : 10_1101-2021_01_06_425584 487 16 Cheng Cheng NNP 10_1101-2021_01_06_425584 487 17 , , , 10_1101-2021_01_06_425584 487 18 S. S. NNP 10_1101-2021_01_06_425584 487 19 ; ; : 10_1101-2021_01_06_425584 487 20 Rhee Rhee NNP 10_1101-2021_01_06_425584 487 21 , , , 10_1101-2021_01_06_425584 487 22 E. E. NNP 10_1101-2021_01_06_425584 487 23 P. P. NNP 10_1101-2021_01_06_425584 487 24 ; ; : 10_1101-2021_01_06_425584 487 25 McCabe McCabe NNP 10_1101-2021_01_06_425584 487 26 , , , 10_1101-2021_01_06_425584 487 27 E. E. NNP 10_1101-2021_01_06_425584 487 28 ; ; : 10_1101-2021_01_06_425584 487 29 Lewis Lewis NNP 10_1101-2021_01_06_425584 487 30 , , , 10_1101-2021_01_06_425584 487 31 G. G. NNP 10_1101-2021_01_06_425584 487 32 734 734 CD 10_1101-2021_01_06_425584 487 33 D. D. NNP 10_1101-2021_01_06_425584 487 34 ; ; : 10_1101-2021_01_06_425584 487 35 Fox Fox NNP 10_1101-2021_01_06_425584 487 36 , , , 10_1101-2021_01_06_425584 487 37 C. C. NNP 10_1101-2021_01_06_425584 487 38 S. S. NNP 10_1101-2021_01_06_425584 487 39 ; ; : 10_1101-2021_01_06_425584 487 40 Jacques Jacques NNP 10_1101-2021_01_06_425584 487 41 , , , 10_1101-2021_01_06_425584 487 42 P. P. NNP 10_1101-2021_01_06_425584 487 43 F. F. NNP 10_1101-2021_01_06_425584 487 44 ; ; : 10_1101-2021_01_06_425584 487 45 Fernandez Fernandez NNP 10_1101-2021_01_06_425584 487 46 , , , 10_1101-2021_01_06_425584 487 47 C. C. NNP 10_1101-2021_01_06_425584 487 48 ; ; : 10_1101-2021_01_06_425584 487 49 O'Donnell O'Donnell NNP 10_1101-2021_01_06_425584 487 50 , , , 10_1101-2021_01_06_425584 487 51 C. C. NNP 10_1101-2021_01_06_425584 487 52 J. J. NNP 10_1101-2021_01_06_425584 487 53 ; ; : 10_1101-2021_01_06_425584 487 54 Carr Carr NNP 10_1101-2021_01_06_425584 487 55 , , , 10_1101-2021_01_06_425584 487 56 S. S. NNP 10_1101-2021_01_06_425584 487 57 A. A. NNP 10_1101-2021_01_06_425584 487 58 ; ; : 10_1101-2021_01_06_425584 487 59 Mootha Mootha NNP 10_1101-2021_01_06_425584 487 60 , , , 10_1101-2021_01_06_425584 487 61 V. V. NNP 10_1101-2021_01_06_425584 487 62 K. K. NNP 10_1101-2021_01_06_425584 487 63 ; ; : 10_1101-2021_01_06_425584 487 64 735 735 CD 10_1101-2021_01_06_425584 487 65 Florez Florez NNP 10_1101-2021_01_06_425584 487 66 , , , 10_1101-2021_01_06_425584 487 67 J. J. NNP 10_1101-2021_01_06_425584 487 68 C. C. NNP 10_1101-2021_01_06_425584 487 69 ; ; : 10_1101-2021_01_06_425584 487 70 Souza Souza NNP 10_1101-2021_01_06_425584 487 71 , , , 10_1101-2021_01_06_425584 487 72 A. a. NN 10_1101-2021_01_06_425584 487 73 ; ; : 10_1101-2021_01_06_425584 487 74 Melander Melander NNP 10_1101-2021_01_06_425584 487 75 , , , 10_1101-2021_01_06_425584 487 76 O. O. NNP 10_1101-2021_01_06_425584 487 77 ; ; : 10_1101-2021_01_06_425584 487 78 Clish Clish NNP 10_1101-2021_01_06_425584 487 79 , , , 10_1101-2021_01_06_425584 487 80 C. C. NNP 10_1101-2021_01_06_425584 487 81 B. B. NNP 10_1101-2021_01_06_425584 487 82 ; ; : 10_1101-2021_01_06_425584 487 83 Gerszten Gerszten NNP 10_1101-2021_01_06_425584 487 84 , , , 10_1101-2021_01_06_425584 487 85 R. R. NNP 10_1101-2021_01_06_425584 487 86 E. E. NNP 10_1101-2021_01_06_425584 487 87 , , , 10_1101-2021_01_06_425584 487 88 Metabolite Metabolite NNP 10_1101-2021_01_06_425584 487 89 profiles profile NNS 10_1101-2021_01_06_425584 487 90 and and CC 10_1101-2021_01_06_425584 487 91 the the DT 10_1101-2021_01_06_425584 487 92 736 736 CD 10_1101-2021_01_06_425584 487 93 risk risk NN 10_1101-2021_01_06_425584 487 94 of of IN 10_1101-2021_01_06_425584 487 95 developing develop VBG 10_1101-2021_01_06_425584 487 96 diabetes diabete NNS 10_1101-2021_01_06_425584 487 97 . . . 10_1101-2021_01_06_425584 488 1 Nat Nat NNP 10_1101-2021_01_06_425584 488 2 Med Med NNP 10_1101-2021_01_06_425584 488 3 2011 2011 CD 10_1101-2021_01_06_425584 488 4 , , , 10_1101-2021_01_06_425584 488 5 17 17 CD 10_1101-2021_01_06_425584 488 6 , , , 10_1101-2021_01_06_425584 488 7 ( ( -LRB- 10_1101-2021_01_06_425584 488 8 4 4 CD 10_1101-2021_01_06_425584 488 9 ) ) -RRB- 10_1101-2021_01_06_425584 488 10 , , , 10_1101-2021_01_06_425584 488 11 448 448 CD 10_1101-2021_01_06_425584 488 12 - - SYM 10_1101-2021_01_06_425584 488 13 53 53 CD 10_1101-2021_01_06_425584 488 14 . . . 10_1101-2021_01_06_425584 489 1 737 737 CD 10_1101-2021_01_06_425584 489 2 60 60 CD 10_1101-2021_01_06_425584 489 3 . . . 10_1101-2021_01_06_425584 490 1 Koziel Koziel NNP 10_1101-2021_01_06_425584 490 2 , , , 10_1101-2021_01_06_425584 490 3 A. A. NNP 10_1101-2021_01_06_425584 490 4 ; ; : 10_1101-2021_01_06_425584 490 5 Woyda Woyda NNP 10_1101-2021_01_06_425584 490 6 - - HYPH 10_1101-2021_01_06_425584 490 7 Ploszczyca Ploszczyca NNP 10_1101-2021_01_06_425584 490 8 , , , 10_1101-2021_01_06_425584 490 9 A. a. NN 10_1101-2021_01_06_425584 490 10 ; ; : 10_1101-2021_01_06_425584 490 11 Kicinska Kicinska NNP 10_1101-2021_01_06_425584 490 12 , , , 10_1101-2021_01_06_425584 490 13 A. a. NN 10_1101-2021_01_06_425584 490 14 ; ; : 10_1101-2021_01_06_425584 490 15 Jarmuszkiewicz Jarmuszkiewicz NNP 10_1101-2021_01_06_425584 490 16 , , , 10_1101-2021_01_06_425584 490 17 W. W. NNP 10_1101-2021_01_06_425584 490 18 , , , 10_1101-2021_01_06_425584 490 19 The the DT 10_1101-2021_01_06_425584 490 20 influence influence NN 10_1101-2021_01_06_425584 490 21 of of IN 10_1101-2021_01_06_425584 490 22 738 738 CD 10_1101-2021_01_06_425584 490 23 high high JJ 10_1101-2021_01_06_425584 490 24 glucose glucose NN 10_1101-2021_01_06_425584 490 25 on on IN 10_1101-2021_01_06_425584 490 26 the the DT 10_1101-2021_01_06_425584 490 27 aerobic aerobic JJ 10_1101-2021_01_06_425584 490 28 metabolism metabolism NN 10_1101-2021_01_06_425584 490 29 of of IN 10_1101-2021_01_06_425584 490 30 endothelial endothelial JJ 10_1101-2021_01_06_425584 490 31 EA.hy926 ea.hy926 JJ 10_1101-2021_01_06_425584 490 32 cells cell NNS 10_1101-2021_01_06_425584 490 33 . . . 10_1101-2021_01_06_425584 491 1 Pflugers Pflugers NNP 10_1101-2021_01_06_425584 491 2 Arch Arch NNP 10_1101-2021_01_06_425584 491 3 2012 2012 CD 10_1101-2021_01_06_425584 491 4 , , , 10_1101-2021_01_06_425584 491 5 464 464 CD 10_1101-2021_01_06_425584 491 6 , , , 10_1101-2021_01_06_425584 491 7 739 739 CD 10_1101-2021_01_06_425584 491 8 ( ( -LRB- 10_1101-2021_01_06_425584 491 9 6 6 CD 10_1101-2021_01_06_425584 491 10 ) ) -RRB- 10_1101-2021_01_06_425584 491 11 , , , 10_1101-2021_01_06_425584 491 12 657 657 CD 10_1101-2021_01_06_425584 491 13 - - SYM 10_1101-2021_01_06_425584 491 14 69 69 CD 10_1101-2021_01_06_425584 491 15 . . . 10_1101-2021_01_06_425584 492 1 740 740 CD 10_1101-2021_01_06_425584 492 2 61 61 CD 10_1101-2021_01_06_425584 492 3 . . . 10_1101-2021_01_06_425584 493 1 Badawy Badawy NNP 10_1101-2021_01_06_425584 493 2 , , , 10_1101-2021_01_06_425584 493 3 A. a. NN 10_1101-2021_01_06_425584 494 1 A. A. NNP 10_1101-2021_01_06_425584 494 2 , , , 10_1101-2021_01_06_425584 494 3 Kynurenine Kynurenine NNP 10_1101-2021_01_06_425584 494 4 Pathway Pathway NNP 10_1101-2021_01_06_425584 494 5 of of IN 10_1101-2021_01_06_425584 494 6 Tryptophan Tryptophan NNP 10_1101-2021_01_06_425584 494 7 Metabolism Metabolism NNP 10_1101-2021_01_06_425584 494 8 : : : 10_1101-2021_01_06_425584 494 9 Regulatory regulatory JJ 10_1101-2021_01_06_425584 494 10 and and CC 10_1101-2021_01_06_425584 494 11 741 741 CD 10_1101-2021_01_06_425584 494 12 Functional Functional NNP 10_1101-2021_01_06_425584 494 13 Aspects Aspects NNPS 10_1101-2021_01_06_425584 494 14 . . . 10_1101-2021_01_06_425584 495 1 Int Int NNP 10_1101-2021_01_06_425584 495 2 J J NNP 10_1101-2021_01_06_425584 495 3 Tryptophan Tryptophan NNP 10_1101-2021_01_06_425584 495 4 Res Res NNP 10_1101-2021_01_06_425584 495 5 2017 2017 CD 10_1101-2021_01_06_425584 495 6 , , , 10_1101-2021_01_06_425584 495 7 10 10 CD 10_1101-2021_01_06_425584 495 8 , , , 10_1101-2021_01_06_425584 495 9 1178646917691938 1178646917691938 CD 10_1101-2021_01_06_425584 495 10 . . . 10_1101-2021_01_06_425584 496 1 742 742 CD 10_1101-2021_01_06_425584 496 2 62 62 CD 10_1101-2021_01_06_425584 496 3 . . . 10_1101-2021_01_06_425584 497 1 Pedersen Pedersen NNP 10_1101-2021_01_06_425584 497 2 , , , 10_1101-2021_01_06_425584 497 3 E. E. NNP 10_1101-2021_01_06_425584 497 4 R. R. NNP 10_1101-2021_01_06_425584 497 5 ; ; : 10_1101-2021_01_06_425584 497 6 Tuseth Tuseth NNP 10_1101-2021_01_06_425584 497 7 , , , 10_1101-2021_01_06_425584 497 8 N. N. NNP 10_1101-2021_01_06_425584 497 9 ; ; : 10_1101-2021_01_06_425584 497 10 Eussen Eussen NNP 10_1101-2021_01_06_425584 497 11 , , , 10_1101-2021_01_06_425584 497 12 S. S. NNP 10_1101-2021_01_06_425584 497 13 J. J. NNP 10_1101-2021_01_06_425584 497 14 ; ; : 10_1101-2021_01_06_425584 497 15 Ueland Ueland NNP 10_1101-2021_01_06_425584 497 16 , , , 10_1101-2021_01_06_425584 497 17 P. P. NNP 10_1101-2021_01_06_425584 497 18 M. M. NNP 10_1101-2021_01_06_425584 497 19 ; ; : 10_1101-2021_01_06_425584 497 20 Strand Strand NNP 10_1101-2021_01_06_425584 497 21 , , , 10_1101-2021_01_06_425584 497 22 E. E. NNP 10_1101-2021_01_06_425584 497 23 ; ; : 10_1101-2021_01_06_425584 497 24 Svingen Svingen NNP 10_1101-2021_01_06_425584 497 25 , , , 10_1101-2021_01_06_425584 497 26 G. G. NNP 10_1101-2021_01_06_425584 497 27 F. F. NNP 10_1101-2021_01_06_425584 497 28 ; ; : 10_1101-2021_01_06_425584 497 29 743 743 CD 10_1101-2021_01_06_425584 497 30 Midttun Midttun NNP 10_1101-2021_01_06_425584 497 31 , , , 10_1101-2021_01_06_425584 497 32 O. O. NNP 10_1101-2021_01_06_425584 497 33 ; ; : 10_1101-2021_01_06_425584 497 34 Meyer Meyer NNP 10_1101-2021_01_06_425584 497 35 , , , 10_1101-2021_01_06_425584 497 36 K. K. NNP 10_1101-2021_01_06_425584 497 37 ; ; : 10_1101-2021_01_06_425584 497 38 Mellgren Mellgren NNP 10_1101-2021_01_06_425584 497 39 , , , 10_1101-2021_01_06_425584 497 40 G. G. NNP 10_1101-2021_01_06_425584 497 41 ; ; : 10_1101-2021_01_06_425584 497 42 Ulvik Ulvik NNP 10_1101-2021_01_06_425584 497 43 , , , 10_1101-2021_01_06_425584 497 44 A. a. NN 10_1101-2021_01_06_425584 497 45 ; ; : 10_1101-2021_01_06_425584 497 46 Nordrehaug Nordrehaug NNP 10_1101-2021_01_06_425584 497 47 , , , 10_1101-2021_01_06_425584 497 48 J. J. NNP 10_1101-2021_01_06_425584 497 49 E. E. NNP 10_1101-2021_01_06_425584 497 50 ; ; : 10_1101-2021_01_06_425584 497 51 Nilsen Nilsen NNP 10_1101-2021_01_06_425584 497 52 , , , 10_1101-2021_01_06_425584 497 53 D. D. NNP 10_1101-2021_01_06_425584 497 54 W. W. NNP 10_1101-2021_01_06_425584 497 55 ; ; : 10_1101-2021_01_06_425584 497 56 Nygard Nygard NNP 10_1101-2021_01_06_425584 497 57 , , , 10_1101-2021_01_06_425584 497 58 O. O. NNP 10_1101-2021_01_06_425584 497 59 , , , 10_1101-2021_01_06_425584 497 60 744 744 CD 10_1101-2021_01_06_425584 497 61 Associations Associations NNPS 10_1101-2021_01_06_425584 497 62 of of IN 10_1101-2021_01_06_425584 497 63 plasma plasma NN 10_1101-2021_01_06_425584 497 64 kynurenines kynurenine NNS 10_1101-2021_01_06_425584 497 65 with with IN 10_1101-2021_01_06_425584 497 66 risk risk NN 10_1101-2021_01_06_425584 497 67 of of IN 10_1101-2021_01_06_425584 497 68 acute acute JJ 10_1101-2021_01_06_425584 497 69 myocardial myocardial JJ 10_1101-2021_01_06_425584 497 70 infarction infarction NN 10_1101-2021_01_06_425584 497 71 in in IN 10_1101-2021_01_06_425584 497 72 patients patient NNS 10_1101-2021_01_06_425584 497 73 with with IN 10_1101-2021_01_06_425584 497 74 745 745 CD 10_1101-2021_01_06_425584 497 75 stable stable JJ 10_1101-2021_01_06_425584 497 76 angina angina NN 10_1101-2021_01_06_425584 497 77 pectoris pectoris NN 10_1101-2021_01_06_425584 497 78 . . . 10_1101-2021_01_06_425584 498 1 Arterioscler Arterioscler NNP 10_1101-2021_01_06_425584 498 2 Thromb Thromb NNP 10_1101-2021_01_06_425584 498 3 Vasc Vasc NNP 10_1101-2021_01_06_425584 498 4 Biol Biol NNP 10_1101-2021_01_06_425584 498 5 2015 2015 CD 10_1101-2021_01_06_425584 498 6 , , , 10_1101-2021_01_06_425584 498 7 35 35 CD 10_1101-2021_01_06_425584 498 8 , , , 10_1101-2021_01_06_425584 498 9 ( ( -LRB- 10_1101-2021_01_06_425584 498 10 2 2 CD 10_1101-2021_01_06_425584 498 11 ) ) -RRB- 10_1101-2021_01_06_425584 498 12 , , , 10_1101-2021_01_06_425584 498 13 455 455 CD 10_1101-2021_01_06_425584 498 14 - - SYM 10_1101-2021_01_06_425584 498 15 62 62 CD 10_1101-2021_01_06_425584 498 16 . . . 10_1101-2021_01_06_425584 499 1 746 746 CD 10_1101-2021_01_06_425584 499 2 63 63 CD 10_1101-2021_01_06_425584 499 3 . . . 10_1101-2021_01_06_425584 500 1 Sulo sulo VB 10_1101-2021_01_06_425584 500 2 , , , 10_1101-2021_01_06_425584 500 3 G. G. NNP 10_1101-2021_01_06_425584 500 4 ; ; : 10_1101-2021_01_06_425584 500 5 Vollset Vollset NNP 10_1101-2021_01_06_425584 500 6 , , , 10_1101-2021_01_06_425584 500 7 S. S. NNP 10_1101-2021_01_06_425584 500 8 E. E. NNP 10_1101-2021_01_06_425584 500 9 ; ; : 10_1101-2021_01_06_425584 500 10 Nygard Nygard NNP 10_1101-2021_01_06_425584 500 11 , , , 10_1101-2021_01_06_425584 500 12 O. O. NNP 10_1101-2021_01_06_425584 500 13 ; ; : 10_1101-2021_01_06_425584 500 14 Midttun Midttun NNP 10_1101-2021_01_06_425584 500 15 , , , 10_1101-2021_01_06_425584 500 16 O. O. NNP 10_1101-2021_01_06_425584 500 17 ; ; : 10_1101-2021_01_06_425584 500 18 Ueland Ueland NNP 10_1101-2021_01_06_425584 500 19 , , , 10_1101-2021_01_06_425584 500 20 P. P. NNP 10_1101-2021_01_06_425584 500 21 M. M. NNP 10_1101-2021_01_06_425584 500 22 ; ; : 10_1101-2021_01_06_425584 500 23 Eussen Eussen NNP 10_1101-2021_01_06_425584 500 24 , , , 10_1101-2021_01_06_425584 500 25 S. S. NNP 10_1101-2021_01_06_425584 500 26 J. J. NNP 10_1101-2021_01_06_425584 500 27 ; ; : 10_1101-2021_01_06_425584 500 28 Pedersen Pedersen NNP 10_1101-2021_01_06_425584 500 29 , , , 10_1101-2021_01_06_425584 500 30 747 747 CD 10_1101-2021_01_06_425584 500 31 E. E. NNP 10_1101-2021_01_06_425584 500 32 R. R. NNP 10_1101-2021_01_06_425584 500 33 ; ; : 10_1101-2021_01_06_425584 500 34 Tell Tell NNP 10_1101-2021_01_06_425584 500 35 , , , 10_1101-2021_01_06_425584 500 36 G. G. NNP 10_1101-2021_01_06_425584 500 37 S. S. NNP 10_1101-2021_01_06_425584 500 38 , , , 10_1101-2021_01_06_425584 500 39 Neopterin Neopterin NNP 10_1101-2021_01_06_425584 500 40 and and CC 10_1101-2021_01_06_425584 500 41 kynurenine kynurenine NNP 10_1101-2021_01_06_425584 500 42 - - HYPH 10_1101-2021_01_06_425584 500 43 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 500 44 ratio ratio NN 10_1101-2021_01_06_425584 500 45 as as IN 10_1101-2021_01_06_425584 500 46 predictors predictor NNS 10_1101-2021_01_06_425584 500 47 of of IN 10_1101-2021_01_06_425584 500 48 coronary coronary JJ 10_1101-2021_01_06_425584 500 49 events event NNS 10_1101-2021_01_06_425584 500 50 in in IN 10_1101-2021_01_06_425584 500 51 748 748 CD 10_1101-2021_01_06_425584 500 52 older old JJR 10_1101-2021_01_06_425584 500 53 adults adult NNS 10_1101-2021_01_06_425584 500 54 , , , 10_1101-2021_01_06_425584 500 55 the the DT 10_1101-2021_01_06_425584 500 56 Hordaland Hordaland NNP 10_1101-2021_01_06_425584 500 57 Health Health NNP 10_1101-2021_01_06_425584 500 58 Study Study NNP 10_1101-2021_01_06_425584 500 59 . . . 10_1101-2021_01_06_425584 501 1 Int Int NNP 10_1101-2021_01_06_425584 501 2 J J NNP 10_1101-2021_01_06_425584 501 3 Cardiol Cardiol NNP 10_1101-2021_01_06_425584 501 4 2013 2013 CD 10_1101-2021_01_06_425584 501 5 , , , 10_1101-2021_01_06_425584 501 6 168 168 CD 10_1101-2021_01_06_425584 501 7 , , , 10_1101-2021_01_06_425584 501 8 ( ( -LRB- 10_1101-2021_01_06_425584 501 9 2 2 CD 10_1101-2021_01_06_425584 501 10 ) ) -RRB- 10_1101-2021_01_06_425584 501 11 , , , 10_1101-2021_01_06_425584 501 12 1435 1435 CD 10_1101-2021_01_06_425584 501 13 - - SYM 10_1101-2021_01_06_425584 501 14 40 40 CD 10_1101-2021_01_06_425584 501 15 . . . 10_1101-2021_01_06_425584 502 1 749 749 CD 10_1101-2021_01_06_425584 502 2 64 64 CD 10_1101-2021_01_06_425584 502 3 . . . 10_1101-2021_01_06_425584 503 1 Polyzos Polyzos NNP 10_1101-2021_01_06_425584 503 2 , , , 10_1101-2021_01_06_425584 503 3 K. K. NNP 10_1101-2021_01_06_425584 503 4 A. A. NNP 10_1101-2021_01_06_425584 503 5 ; ; : 10_1101-2021_01_06_425584 503 6 Ketelhuth Ketelhuth NNP 10_1101-2021_01_06_425584 503 7 , , , 10_1101-2021_01_06_425584 503 8 D. D. NNP 10_1101-2021_01_06_425584 503 9 F. F. NNP 10_1101-2021_01_06_425584 503 10 , , , 10_1101-2021_01_06_425584 503 11 The the DT 10_1101-2021_01_06_425584 503 12 role role NN 10_1101-2021_01_06_425584 503 13 of of IN 10_1101-2021_01_06_425584 503 14 the the DT 10_1101-2021_01_06_425584 503 15 kynurenine kynurenine NNP 10_1101-2021_01_06_425584 503 16 pathway pathway NN 10_1101-2021_01_06_425584 503 17 of of IN 10_1101-2021_01_06_425584 503 18 tryptophan tryptophan NNP 10_1101-2021_01_06_425584 503 19 750 750 CD 10_1101-2021_01_06_425584 503 20 metabolism metabolism NN 10_1101-2021_01_06_425584 503 21 in in IN 10_1101-2021_01_06_425584 503 22 cardiovascular cardiovascular JJ 10_1101-2021_01_06_425584 503 23 disease disease NN 10_1101-2021_01_06_425584 503 24 . . . 10_1101-2021_01_06_425584 504 1 An an DT 10_1101-2021_01_06_425584 504 2 emerging emerge VBG 10_1101-2021_01_06_425584 504 3 field field NN 10_1101-2021_01_06_425584 504 4 . . . 10_1101-2021_01_06_425584 505 1 Hamostaseologie Hamostaseologie NNP 10_1101-2021_01_06_425584 505 2 2015 2015 CD 10_1101-2021_01_06_425584 505 3 , , , 10_1101-2021_01_06_425584 505 4 35 35 CD 10_1101-2021_01_06_425584 505 5 , , , 10_1101-2021_01_06_425584 505 6 ( ( -LRB- 10_1101-2021_01_06_425584 505 7 2 2 CD 10_1101-2021_01_06_425584 505 8 ) ) -RRB- 10_1101-2021_01_06_425584 505 9 , , , 10_1101-2021_01_06_425584 505 10 128 128 CD 10_1101-2021_01_06_425584 505 11 - - SYM 10_1101-2021_01_06_425584 505 12 751 751 CD 10_1101-2021_01_06_425584 505 13 36 36 CD 10_1101-2021_01_06_425584 505 14 . . . 10_1101-2021_01_06_425584 506 1 752 752 CD 10_1101-2021_01_06_425584 506 2 65 65 CD 10_1101-2021_01_06_425584 506 3 . . . 10_1101-2021_01_06_425584 507 1 Aquilano Aquilano NNP 10_1101-2021_01_06_425584 507 2 , , , 10_1101-2021_01_06_425584 507 3 K. K. NNP 10_1101-2021_01_06_425584 507 4 ; ; : 10_1101-2021_01_06_425584 507 5 Baldelli Baldelli NNP 10_1101-2021_01_06_425584 507 6 , , , 10_1101-2021_01_06_425584 507 7 S. S. NNP 10_1101-2021_01_06_425584 507 8 ; ; : 10_1101-2021_01_06_425584 507 9 Ciriolo Ciriolo NNP 10_1101-2021_01_06_425584 507 10 , , , 10_1101-2021_01_06_425584 507 11 M. M. NNP 10_1101-2021_01_06_425584 507 12 R. R. NNP 10_1101-2021_01_06_425584 507 13 , , , 10_1101-2021_01_06_425584 507 14 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 507 15 : : : 10_1101-2021_01_06_425584 507 16 new new JJ 10_1101-2021_01_06_425584 507 17 roles role NNS 10_1101-2021_01_06_425584 507 18 in in IN 10_1101-2021_01_06_425584 507 19 redox redox NN 10_1101-2021_01_06_425584 507 20 signaling signaling NN 10_1101-2021_01_06_425584 507 21 for for IN 10_1101-2021_01_06_425584 507 22 an an DT 10_1101-2021_01_06_425584 507 23 753 753 CD 10_1101-2021_01_06_425584 507 24 old old JJ 10_1101-2021_01_06_425584 507 25 antioxidant antioxidant NN 10_1101-2021_01_06_425584 507 26 . . . 10_1101-2021_01_06_425584 508 1 Front Front NNP 10_1101-2021_01_06_425584 508 2 Pharmacol Pharmacol NNP 10_1101-2021_01_06_425584 508 3 2014 2014 CD 10_1101-2021_01_06_425584 508 4 , , , 10_1101-2021_01_06_425584 508 5 5 5 CD 10_1101-2021_01_06_425584 508 6 , , , 10_1101-2021_01_06_425584 508 7 196 196 CD 10_1101-2021_01_06_425584 508 8 . . . 10_1101-2021_01_06_425584 509 1 754 754 CD 10_1101-2021_01_06_425584 509 2 66 66 CD 10_1101-2021_01_06_425584 509 3 . . . 10_1101-2021_01_06_425584 510 1 Yuan Yuan NNP 10_1101-2021_01_06_425584 510 2 , , , 10_1101-2021_01_06_425584 510 3 W. W. NNP 10_1101-2021_01_06_425584 510 4 ; ; : 10_1101-2021_01_06_425584 510 5 Edwards Edwards NNP 10_1101-2021_01_06_425584 510 6 , , , 10_1101-2021_01_06_425584 510 7 J. J. NNP 10_1101-2021_01_06_425584 510 8 L. L. NNP 10_1101-2021_01_06_425584 510 9 , , , 10_1101-2021_01_06_425584 510 10 Thiol Thiol NNP 10_1101-2021_01_06_425584 510 11 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 510 12 of of IN 10_1101-2021_01_06_425584 510 13 endothelial endothelial JJ 10_1101-2021_01_06_425584 510 14 cells cell NNS 10_1101-2021_01_06_425584 510 15 using use VBG 10_1101-2021_01_06_425584 510 16 capillary capillary JJ 10_1101-2021_01_06_425584 510 17 liquid liquid NN 10_1101-2021_01_06_425584 510 18 755 755 CD 10_1101-2021_01_06_425584 510 19 chromatography chromatography NN 10_1101-2021_01_06_425584 510 20 mass mass NN 10_1101-2021_01_06_425584 510 21 spectrometry spectrometry NN 10_1101-2021_01_06_425584 510 22 with with IN 10_1101-2021_01_06_425584 510 23 isotope isotope NN 10_1101-2021_01_06_425584 510 24 coded code VBN 10_1101-2021_01_06_425584 510 25 affinity affinity NN 10_1101-2021_01_06_425584 510 26 tags tag NNS 10_1101-2021_01_06_425584 510 27 . . . 10_1101-2021_01_06_425584 511 1 J J NNP 10_1101-2021_01_06_425584 511 2 Chromatogr Chromatogr NNP 10_1101-2021_01_06_425584 511 3 A a DT 10_1101-2021_01_06_425584 511 4 2011 2011 CD 10_1101-2021_01_06_425584 511 5 , , , 10_1101-2021_01_06_425584 511 6 756 756 CD 10_1101-2021_01_06_425584 511 7 1218 1218 CD 10_1101-2021_01_06_425584 511 8 , , , 10_1101-2021_01_06_425584 511 9 ( ( -LRB- 10_1101-2021_01_06_425584 511 10 18 18 CD 10_1101-2021_01_06_425584 511 11 ) ) -RRB- 10_1101-2021_01_06_425584 511 12 , , , 10_1101-2021_01_06_425584 511 13 2561 2561 CD 10_1101-2021_01_06_425584 511 14 - - SYM 10_1101-2021_01_06_425584 511 15 8 8 CD 10_1101-2021_01_06_425584 511 16 . . . 10_1101-2021_01_06_425584 512 1 757 757 CD 10_1101-2021_01_06_425584 512 2 67 67 CD 10_1101-2021_01_06_425584 512 3 . . . 10_1101-2021_01_06_425584 513 1 Weidig Weidig NNP 10_1101-2021_01_06_425584 513 2 , , , 10_1101-2021_01_06_425584 513 3 P. P. NNP 10_1101-2021_01_06_425584 513 4 ; ; : 10_1101-2021_01_06_425584 513 5 McMaster McMaster NNP 10_1101-2021_01_06_425584 513 6 , , , 10_1101-2021_01_06_425584 513 7 D. D. NNP 10_1101-2021_01_06_425584 513 8 ; ; : 10_1101-2021_01_06_425584 513 9 Bayraktutan Bayraktutan NNP 10_1101-2021_01_06_425584 513 10 , , , 10_1101-2021_01_06_425584 513 11 U. U. NNP 10_1101-2021_01_06_425584 513 12 , , , 10_1101-2021_01_06_425584 513 13 High high JJ 10_1101-2021_01_06_425584 513 14 glucose glucose NN 10_1101-2021_01_06_425584 513 15 mediates mediate VBZ 10_1101-2021_01_06_425584 513 16 pro pro JJ 10_1101-2021_01_06_425584 513 17 - - JJ 10_1101-2021_01_06_425584 513 18 oxidant oxidant JJ 10_1101-2021_01_06_425584 513 19 and and CC 10_1101-2021_01_06_425584 513 20 758 758 CD 10_1101-2021_01_06_425584 513 21 antioxidant antioxidant JJ 10_1101-2021_01_06_425584 513 22 enzyme enzyme NNS 10_1101-2021_01_06_425584 513 23 activities activity NNS 10_1101-2021_01_06_425584 513 24 in in IN 10_1101-2021_01_06_425584 513 25 coronary coronary JJ 10_1101-2021_01_06_425584 513 26 endothelial endothelial JJ 10_1101-2021_01_06_425584 513 27 cells cell NNS 10_1101-2021_01_06_425584 513 28 . . . 10_1101-2021_01_06_425584 514 1 Diabetes diabetes NN 10_1101-2021_01_06_425584 514 2 Obes Obes NNP 10_1101-2021_01_06_425584 514 3 Metab Metab NNP 10_1101-2021_01_06_425584 514 4 2004 2004 CD 10_1101-2021_01_06_425584 514 5 , , , 10_1101-2021_01_06_425584 514 6 6 6 CD 10_1101-2021_01_06_425584 514 7 , , , 10_1101-2021_01_06_425584 514 8 ( ( -LRB- 10_1101-2021_01_06_425584 514 9 6 6 CD 10_1101-2021_01_06_425584 514 10 ) ) -RRB- 10_1101-2021_01_06_425584 514 11 , , , 10_1101-2021_01_06_425584 514 12 759 759 CD 10_1101-2021_01_06_425584 514 13 432 432 CD 10_1101-2021_01_06_425584 514 14 - - SYM 10_1101-2021_01_06_425584 514 15 41 41 CD 10_1101-2021_01_06_425584 514 16 . . . 10_1101-2021_01_06_425584 515 1 760 760 CD 10_1101-2021_01_06_425584 515 2 68 68 CD 10_1101-2021_01_06_425584 515 3 . . . 10_1101-2021_01_06_425584 516 1 Felice Felice NNP 10_1101-2021_01_06_425584 516 2 , , , 10_1101-2021_01_06_425584 516 3 F. F. NNP 10_1101-2021_01_06_425584 516 4 ; ; : 10_1101-2021_01_06_425584 516 5 Lucchesi Lucchesi NNP 10_1101-2021_01_06_425584 516 6 , , , 10_1101-2021_01_06_425584 516 7 D. D. NNP 10_1101-2021_01_06_425584 516 8 ; ; : 10_1101-2021_01_06_425584 516 9 di di NNP 10_1101-2021_01_06_425584 516 10 Stefano Stefano NNP 10_1101-2021_01_06_425584 516 11 , , , 10_1101-2021_01_06_425584 516 12 R. R. NNP 10_1101-2021_01_06_425584 516 13 ; ; : 10_1101-2021_01_06_425584 516 14 Barsotti Barsotti NNP 10_1101-2021_01_06_425584 516 15 , , , 10_1101-2021_01_06_425584 516 16 M. M. NNP 10_1101-2021_01_06_425584 516 17 C. C. NNP 10_1101-2021_01_06_425584 516 18 ; ; : 10_1101-2021_01_06_425584 516 19 Storti Storti NNP 10_1101-2021_01_06_425584 516 20 , , , 10_1101-2021_01_06_425584 516 21 E. E. NNP 10_1101-2021_01_06_425584 516 22 ; ; : 10_1101-2021_01_06_425584 516 23 Penno Penno NNP 10_1101-2021_01_06_425584 516 24 , , , 10_1101-2021_01_06_425584 516 25 G. G. NNP 10_1101-2021_01_06_425584 516 26 ; ; : 10_1101-2021_01_06_425584 516 27 Balbarini Balbarini NNP 10_1101-2021_01_06_425584 516 28 , , , 10_1101-2021_01_06_425584 516 29 761 761 CD 10_1101-2021_01_06_425584 516 30 A. a. NN 10_1101-2021_01_06_425584 516 31 ; ; : 10_1101-2021_01_06_425584 516 32 Del Del NNP 10_1101-2021_01_06_425584 516 33 Prato Prato NNP 10_1101-2021_01_06_425584 516 34 , , , 10_1101-2021_01_06_425584 516 35 S. S. NNP 10_1101-2021_01_06_425584 516 36 ; ; : 10_1101-2021_01_06_425584 516 37 Pucci Pucci NNP 10_1101-2021_01_06_425584 516 38 , , , 10_1101-2021_01_06_425584 516 39 L. L. NNP 10_1101-2021_01_06_425584 516 40 , , , 10_1101-2021_01_06_425584 516 41 Oxidative Oxidative NNP 10_1101-2021_01_06_425584 516 42 stress stress NN 10_1101-2021_01_06_425584 516 43 in in IN 10_1101-2021_01_06_425584 516 44 response response NN 10_1101-2021_01_06_425584 516 45 to to IN 10_1101-2021_01_06_425584 516 46 high high JJ 10_1101-2021_01_06_425584 516 47 glucose glucose NN 10_1101-2021_01_06_425584 516 48 levels level NNS 10_1101-2021_01_06_425584 516 49 in in IN 10_1101-2021_01_06_425584 516 50 endothelial endothelial JJ 10_1101-2021_01_06_425584 516 51 762 762 CD 10_1101-2021_01_06_425584 516 52 cells cell NNS 10_1101-2021_01_06_425584 516 53 and and CC 10_1101-2021_01_06_425584 516 54 in in IN 10_1101-2021_01_06_425584 516 55 endothelial endothelial JJ 10_1101-2021_01_06_425584 516 56 progenitor progenitor NN 10_1101-2021_01_06_425584 516 57 cells cell NNS 10_1101-2021_01_06_425584 516 58 : : : 10_1101-2021_01_06_425584 516 59 evidence evidence NN 10_1101-2021_01_06_425584 516 60 for for IN 10_1101-2021_01_06_425584 516 61 differential differential NN 10_1101-2021_01_06_425584 516 62 glutathione glutathione NN 10_1101-2021_01_06_425584 516 63 peroxidase-1 peroxidase-1 NNP 10_1101-2021_01_06_425584 516 64 763 763 CD 10_1101-2021_01_06_425584 516 65 expression expression NN 10_1101-2021_01_06_425584 516 66 . . . 10_1101-2021_01_06_425584 517 1 Microvasc Microvasc NNP 10_1101-2021_01_06_425584 517 2 Res Res NNP 10_1101-2021_01_06_425584 517 3 2010 2010 CD 10_1101-2021_01_06_425584 517 4 , , , 10_1101-2021_01_06_425584 517 5 80 80 CD 10_1101-2021_01_06_425584 517 6 , , , 10_1101-2021_01_06_425584 517 7 ( ( -LRB- 10_1101-2021_01_06_425584 517 8 3 3 CD 10_1101-2021_01_06_425584 517 9 ) ) -RRB- 10_1101-2021_01_06_425584 517 10 , , , 10_1101-2021_01_06_425584 517 11 332 332 CD 10_1101-2021_01_06_425584 517 12 - - SYM 10_1101-2021_01_06_425584 517 13 8 8 CD 10_1101-2021_01_06_425584 517 14 . . . 10_1101-2021_01_06_425584 518 1 764 764 CD 10_1101-2021_01_06_425584 518 2 69 69 CD 10_1101-2021_01_06_425584 518 3 . . . 10_1101-2021_01_06_425584 519 1 Kashiwagi Kashiwagi NNP 10_1101-2021_01_06_425584 519 2 , , , 10_1101-2021_01_06_425584 519 3 A. a. NN 10_1101-2021_01_06_425584 519 4 ; ; : 10_1101-2021_01_06_425584 519 5 Asahina Asahina NNP 10_1101-2021_01_06_425584 519 6 , , , 10_1101-2021_01_06_425584 519 7 T. T. NNP 10_1101-2021_01_06_425584 519 8 ; ; : 10_1101-2021_01_06_425584 519 9 Ikebuchi Ikebuchi NNP 10_1101-2021_01_06_425584 519 10 , , , 10_1101-2021_01_06_425584 519 11 M. M. NNP 10_1101-2021_01_06_425584 519 12 ; ; : 10_1101-2021_01_06_425584 519 13 Tanaka Tanaka NNP 10_1101-2021_01_06_425584 519 14 , , , 10_1101-2021_01_06_425584 519 15 Y. Y. NNP 10_1101-2021_01_06_425584 519 16 ; ; : 10_1101-2021_01_06_425584 519 17 Takagi Takagi NNP 10_1101-2021_01_06_425584 519 18 , , , 10_1101-2021_01_06_425584 519 19 Y. Y. NNP 10_1101-2021_01_06_425584 519 20 ; ; : 10_1101-2021_01_06_425584 519 21 Nishio Nishio NNP 10_1101-2021_01_06_425584 519 22 , , , 10_1101-2021_01_06_425584 519 23 Y. Y. NNP 10_1101-2021_01_06_425584 519 24 ; ; : 10_1101-2021_01_06_425584 519 25 Kikkawa Kikkawa NNP 10_1101-2021_01_06_425584 519 26 , , , 10_1101-2021_01_06_425584 519 27 R. R. NNP 10_1101-2021_01_06_425584 519 28 ; ; : 10_1101-2021_01_06_425584 519 29 765 765 CD 10_1101-2021_01_06_425584 519 30 Shigeta Shigeta NNP 10_1101-2021_01_06_425584 519 31 , , , 10_1101-2021_01_06_425584 519 32 Y. Y. NNP 10_1101-2021_01_06_425584 519 33 , , , 10_1101-2021_01_06_425584 519 34 Abnormal Abnormal NNP 10_1101-2021_01_06_425584 519 35 glutathione glutathione VBD 10_1101-2021_01_06_425584 519 36 metabolism metabolism NN 10_1101-2021_01_06_425584 519 37 and and CC 10_1101-2021_01_06_425584 519 38 increased increase VBN 10_1101-2021_01_06_425584 519 39 cytotoxicity cytotoxicity NN 10_1101-2021_01_06_425584 519 40 caused cause VBN 10_1101-2021_01_06_425584 519 41 by by IN 10_1101-2021_01_06_425584 519 42 H2O2 H2O2 NNP 10_1101-2021_01_06_425584 519 43 in in IN 10_1101-2021_01_06_425584 519 44 766 766 CD 10_1101-2021_01_06_425584 519 45 human human JJ 10_1101-2021_01_06_425584 519 46 umbilical umbilical JJ 10_1101-2021_01_06_425584 519 47 vein vein NN 10_1101-2021_01_06_425584 519 48 endothelial endothelial JJ 10_1101-2021_01_06_425584 519 49 cells cell NNS 10_1101-2021_01_06_425584 519 50 cultured culture VBN 10_1101-2021_01_06_425584 519 51 in in IN 10_1101-2021_01_06_425584 519 52 high high JJ 10_1101-2021_01_06_425584 519 53 glucose glucose NN 10_1101-2021_01_06_425584 519 54 medium medium NN 10_1101-2021_01_06_425584 519 55 . . . 10_1101-2021_01_06_425584 520 1 Diabetologia diabetologia NN 10_1101-2021_01_06_425584 520 2 1994 1994 CD 10_1101-2021_01_06_425584 520 3 , , , 10_1101-2021_01_06_425584 520 4 37 37 CD 10_1101-2021_01_06_425584 520 5 , , , 10_1101-2021_01_06_425584 520 6 767 767 CD 10_1101-2021_01_06_425584 520 7 ( ( -LRB- 10_1101-2021_01_06_425584 520 8 3 3 CD 10_1101-2021_01_06_425584 520 9 ) ) -RRB- 10_1101-2021_01_06_425584 520 10 , , , 10_1101-2021_01_06_425584 520 11 264 264 CD 10_1101-2021_01_06_425584 520 12 - - SYM 10_1101-2021_01_06_425584 520 13 9 9 CD 10_1101-2021_01_06_425584 520 14 . . . 10_1101-2021_01_06_425584 521 1 768 768 CD 10_1101-2021_01_06_425584 521 2 70 70 CD 10_1101-2021_01_06_425584 521 3 . . . 10_1101-2021_01_06_425584 522 1 Hanschmann Hanschmann NNP 10_1101-2021_01_06_425584 522 2 , , , 10_1101-2021_01_06_425584 522 3 E. E. NNP 10_1101-2021_01_06_425584 522 4 M. M. NNP 10_1101-2021_01_06_425584 522 5 ; ; : 10_1101-2021_01_06_425584 522 6 Godoy Godoy NNP 10_1101-2021_01_06_425584 522 7 , , , 10_1101-2021_01_06_425584 522 8 J. J. NNP 10_1101-2021_01_06_425584 522 9 R. R. NNP 10_1101-2021_01_06_425584 522 10 ; ; : 10_1101-2021_01_06_425584 522 11 Berndt Berndt NNP 10_1101-2021_01_06_425584 522 12 , , , 10_1101-2021_01_06_425584 522 13 C. C. NNP 10_1101-2021_01_06_425584 522 14 ; ; : 10_1101-2021_01_06_425584 522 15 Hudemann Hudemann NNP 10_1101-2021_01_06_425584 522 16 , , , 10_1101-2021_01_06_425584 522 17 C. C. NNP 10_1101-2021_01_06_425584 522 18 ; ; : 10_1101-2021_01_06_425584 522 19 Lillig Lillig NNP 10_1101-2021_01_06_425584 522 20 , , , 10_1101-2021_01_06_425584 522 21 C. C. NNP 10_1101-2021_01_06_425584 522 22 H. H. NNP 10_1101-2021_01_06_425584 522 23 , , , 10_1101-2021_01_06_425584 522 24 Thioredoxins Thioredoxins NNP 10_1101-2021_01_06_425584 522 25 , , , 10_1101-2021_01_06_425584 522 26 769 769 CD 10_1101-2021_01_06_425584 522 27 glutaredoxins glutaredoxin NNS 10_1101-2021_01_06_425584 522 28 , , , 10_1101-2021_01_06_425584 522 29 and and CC 10_1101-2021_01_06_425584 522 30 peroxiredoxins peroxiredoxin NNS 10_1101-2021_01_06_425584 522 31 -- -- : 10_1101-2021_01_06_425584 522 32 molecular molecular JJ 10_1101-2021_01_06_425584 522 33 mechanisms mechanism NNS 10_1101-2021_01_06_425584 522 34 and and CC 10_1101-2021_01_06_425584 522 35 health health NN 10_1101-2021_01_06_425584 522 36 significance significance NN 10_1101-2021_01_06_425584 522 37 : : : 10_1101-2021_01_06_425584 522 38 from from IN 10_1101-2021_01_06_425584 522 39 770 770 CD 10_1101-2021_01_06_425584 522 40 cofactors cofactor NNS 10_1101-2021_01_06_425584 522 41 to to IN 10_1101-2021_01_06_425584 522 42 antioxidants antioxidant NNS 10_1101-2021_01_06_425584 522 43 to to IN 10_1101-2021_01_06_425584 522 44 redox redox NN 10_1101-2021_01_06_425584 522 45 signaling signaling NN 10_1101-2021_01_06_425584 522 46 . . . 10_1101-2021_01_06_425584 523 1 Antioxid Antioxid NNP 10_1101-2021_01_06_425584 523 2 Redox Redox NNP 10_1101-2021_01_06_425584 523 3 Signal Signal NNP 10_1101-2021_01_06_425584 523 4 2013 2013 CD 10_1101-2021_01_06_425584 523 5 , , , 10_1101-2021_01_06_425584 523 6 19 19 CD 10_1101-2021_01_06_425584 523 7 , , , 10_1101-2021_01_06_425584 523 8 ( ( -LRB- 10_1101-2021_01_06_425584 523 9 13 13 CD 10_1101-2021_01_06_425584 523 10 ) ) -RRB- 10_1101-2021_01_06_425584 523 11 , , , 10_1101-2021_01_06_425584 523 12 1539 1539 CD 10_1101-2021_01_06_425584 523 13 - - SYM 10_1101-2021_01_06_425584 523 14 605 605 CD 10_1101-2021_01_06_425584 523 15 . . . 10_1101-2021_01_06_425584 524 1 771 771 CD 10_1101-2021_01_06_425584 524 2 71 71 CD 10_1101-2021_01_06_425584 524 3 . . . 10_1101-2021_01_06_425584 525 1 Scocchi Scocchi NNP 10_1101-2021_01_06_425584 525 2 , , , 10_1101-2021_01_06_425584 525 3 M. M. NNP 10_1101-2021_01_06_425584 525 4 ; ; : 10_1101-2021_01_06_425584 525 5 Tossi Tossi NNP 10_1101-2021_01_06_425584 525 6 , , , 10_1101-2021_01_06_425584 525 7 A. a. NN 10_1101-2021_01_06_425584 525 8 ; ; : 10_1101-2021_01_06_425584 525 9 Gennaro Gennaro NNP 10_1101-2021_01_06_425584 525 10 , , , 10_1101-2021_01_06_425584 525 11 R. R. NNP 10_1101-2021_01_06_425584 525 12 , , , 10_1101-2021_01_06_425584 525 13 Proline Proline NNP 10_1101-2021_01_06_425584 525 14 - - HYPH 10_1101-2021_01_06_425584 525 15 rich rich JJ 10_1101-2021_01_06_425584 525 16 antimicrobial antimicrobial JJ 10_1101-2021_01_06_425584 525 17 peptides peptide NNS 10_1101-2021_01_06_425584 525 18 : : : 10_1101-2021_01_06_425584 525 19 converging converge VBG 10_1101-2021_01_06_425584 525 20 to to IN 10_1101-2021_01_06_425584 525 21 a a DT 10_1101-2021_01_06_425584 525 22 772 772 CD 10_1101-2021_01_06_425584 525 23 non non JJ 10_1101-2021_01_06_425584 525 24 - - JJ 10_1101-2021_01_06_425584 525 25 lytic lytic JJ 10_1101-2021_01_06_425584 525 26 mechanism mechanism NN 10_1101-2021_01_06_425584 525 27 of of IN 10_1101-2021_01_06_425584 525 28 action action NN 10_1101-2021_01_06_425584 525 29 . . . 10_1101-2021_01_06_425584 526 1 Cell Cell NNP 10_1101-2021_01_06_425584 526 2 Mol Mol NNP 10_1101-2021_01_06_425584 526 3 Life Life NNP 10_1101-2021_01_06_425584 526 4 Sci Sci NNP 10_1101-2021_01_06_425584 526 5 2011 2011 CD 10_1101-2021_01_06_425584 526 6 , , , 10_1101-2021_01_06_425584 526 7 68 68 CD 10_1101-2021_01_06_425584 526 8 , , , 10_1101-2021_01_06_425584 526 9 ( ( -LRB- 10_1101-2021_01_06_425584 526 10 13 13 CD 10_1101-2021_01_06_425584 526 11 ) ) -RRB- 10_1101-2021_01_06_425584 526 12 , , , 10_1101-2021_01_06_425584 526 13 2317 2317 CD 10_1101-2021_01_06_425584 526 14 - - SYM 10_1101-2021_01_06_425584 526 15 30 30 CD 10_1101-2021_01_06_425584 526 16 . . . 10_1101-2021_01_06_425584 527 1 773 773 CD 10_1101-2021_01_06_425584 527 2 .CC .CC : 10_1101-2021_01_06_425584 527 3 - - HYPH 10_1101-2021_01_06_425584 527 4 BY by IN 10_1101-2021_01_06_425584 527 5 - - HYPH 10_1101-2021_01_06_425584 527 6 NC NC NNP 10_1101-2021_01_06_425584 527 7 - - HYPH 10_1101-2021_01_06_425584 527 8 ND ND NNP 10_1101-2021_01_06_425584 527 9 4.0 4.0 CD 10_1101-2021_01_06_425584 527 10 International International NNP 10_1101-2021_01_06_425584 527 11 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 527 12 under under IN 10_1101-2021_01_06_425584 527 13 a a DT 10_1101-2021_01_06_425584 527 14 ( ( -LRB- 10_1101-2021_01_06_425584 527 15 which which WDT 10_1101-2021_01_06_425584 527 16 was be VBD 10_1101-2021_01_06_425584 527 17 not not RB 10_1101-2021_01_06_425584 527 18 certified certify VBN 10_1101-2021_01_06_425584 527 19 by by IN 10_1101-2021_01_06_425584 527 20 peer peer NN 10_1101-2021_01_06_425584 527 21 review review NN 10_1101-2021_01_06_425584 527 22 ) ) -RRB- 10_1101-2021_01_06_425584 527 23 is be VBZ 10_1101-2021_01_06_425584 527 24 the the DT 10_1101-2021_01_06_425584 527 25 author author NN 10_1101-2021_01_06_425584 527 26 / / SYM 10_1101-2021_01_06_425584 527 27 funder funder NN 10_1101-2021_01_06_425584 527 28 , , , 10_1101-2021_01_06_425584 527 29 who who WP 10_1101-2021_01_06_425584 527 30 has have VBZ 10_1101-2021_01_06_425584 527 31 granted grant VBN 10_1101-2021_01_06_425584 527 32 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 527 33 a a DT 10_1101-2021_01_06_425584 527 34 license license NN 10_1101-2021_01_06_425584 527 35 to to TO 10_1101-2021_01_06_425584 527 36 display display VB 10_1101-2021_01_06_425584 527 37 the the DT 10_1101-2021_01_06_425584 527 38 preprint preprint NN 10_1101-2021_01_06_425584 527 39 in in IN 10_1101-2021_01_06_425584 527 40 perpetuity perpetuity NN 10_1101-2021_01_06_425584 527 41 . . . 10_1101-2021_01_06_425584 528 1 It -PRON- PRP 10_1101-2021_01_06_425584 528 2 is be VBZ 10_1101-2021_01_06_425584 528 3 made make VBN 10_1101-2021_01_06_425584 528 4 The the DT 10_1101-2021_01_06_425584 528 5 copyright copyright NN 10_1101-2021_01_06_425584 528 6 holder holder NN 10_1101-2021_01_06_425584 528 7 for for IN 10_1101-2021_01_06_425584 528 8 this this DT 10_1101-2021_01_06_425584 528 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 528 10 version version NN 10_1101-2021_01_06_425584 528 11 posted post VBD 10_1101-2021_01_06_425584 528 12 January January NNP 10_1101-2021_01_06_425584 528 13 8 8 CD 10_1101-2021_01_06_425584 528 14 , , , 10_1101-2021_01_06_425584 528 15 2021 2021 CD 10_1101-2021_01_06_425584 528 16 . . . 10_1101-2021_01_06_425584 528 17 ; ; : 10_1101-2021_01_06_425584 528 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 528 19 : : : 10_1101-2021_01_06_425584 528 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 528 21 preprint preprint NN 10_1101-2021_01_06_425584 528 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 528 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 528 24 26 26 CD 10_1101-2021_01_06_425584 528 25 72 72 CD 10_1101-2021_01_06_425584 528 26 . . . 10_1101-2021_01_06_425584 529 1 Migliaccio Migliaccio NNP 10_1101-2021_01_06_425584 529 2 , , , 10_1101-2021_01_06_425584 529 3 A. a. NN 10_1101-2021_01_06_425584 529 4 ; ; : 10_1101-2021_01_06_425584 529 5 Castoria Castoria NNP 10_1101-2021_01_06_425584 529 6 , , , 10_1101-2021_01_06_425584 529 7 G. G. NNP 10_1101-2021_01_06_425584 529 8 ; ; : 10_1101-2021_01_06_425584 529 9 de de NNP 10_1101-2021_01_06_425584 529 10 Falco Falco NNP 10_1101-2021_01_06_425584 529 11 , , , 10_1101-2021_01_06_425584 529 12 A. a. NN 10_1101-2021_01_06_425584 529 13 ; ; : 10_1101-2021_01_06_425584 529 14 Bilancio Bilancio NNP 10_1101-2021_01_06_425584 529 15 , , , 10_1101-2021_01_06_425584 529 16 A. a. NN 10_1101-2021_01_06_425584 529 17 ; ; : 10_1101-2021_01_06_425584 529 18 Giovannelli Giovannelli NNP 10_1101-2021_01_06_425584 529 19 , , , 10_1101-2021_01_06_425584 529 20 P. P. NNP 10_1101-2021_01_06_425584 529 21 ; ; : 10_1101-2021_01_06_425584 529 22 Di Di NNP 10_1101-2021_01_06_425584 529 23 Donato Donato NNP 10_1101-2021_01_06_425584 529 24 , , , 10_1101-2021_01_06_425584 529 25 M. M. NNP 10_1101-2021_01_06_425584 529 26 ; ; : 10_1101-2021_01_06_425584 529 27 774 774 CD 10_1101-2021_01_06_425584 529 28 Marino Marino NNP 10_1101-2021_01_06_425584 529 29 , , , 10_1101-2021_01_06_425584 529 30 I. i. NN 10_1101-2021_01_06_425584 529 31 ; ; : 10_1101-2021_01_06_425584 529 32 Yamaguchi Yamaguchi NNP 10_1101-2021_01_06_425584 529 33 , , , 10_1101-2021_01_06_425584 529 34 H. H. NNP 10_1101-2021_01_06_425584 529 35 ; ; : 10_1101-2021_01_06_425584 529 36 Appella Appella NNP 10_1101-2021_01_06_425584 529 37 , , , 10_1101-2021_01_06_425584 529 38 E. E. NNP 10_1101-2021_01_06_425584 529 39 ; ; : 10_1101-2021_01_06_425584 529 40 Auricchio Auricchio NNP 10_1101-2021_01_06_425584 529 41 , , , 10_1101-2021_01_06_425584 529 42 F. F. NNP 10_1101-2021_01_06_425584 529 43 , , , 10_1101-2021_01_06_425584 529 44 Polyproline Polyproline NNP 10_1101-2021_01_06_425584 529 45 and and CC 10_1101-2021_01_06_425584 529 46 Tat Tat NNP 10_1101-2021_01_06_425584 529 47 transduction transduction NN 10_1101-2021_01_06_425584 529 48 peptides peptide VBZ 10_1101-2021_01_06_425584 529 49 775 775 CD 10_1101-2021_01_06_425584 529 50 in in IN 10_1101-2021_01_06_425584 529 51 the the DT 10_1101-2021_01_06_425584 529 52 study study NN 10_1101-2021_01_06_425584 529 53 of of IN 10_1101-2021_01_06_425584 529 54 the the DT 10_1101-2021_01_06_425584 529 55 rapid rapid JJ 10_1101-2021_01_06_425584 529 56 actions action NNS 10_1101-2021_01_06_425584 529 57 of of IN 10_1101-2021_01_06_425584 529 58 steroid steroid NN 10_1101-2021_01_06_425584 529 59 receptors receptor NNS 10_1101-2021_01_06_425584 529 60 . . . 10_1101-2021_01_06_425584 530 1 Steroids steroid NNS 10_1101-2021_01_06_425584 530 2 2012 2012 CD 10_1101-2021_01_06_425584 530 3 , , , 10_1101-2021_01_06_425584 530 4 77 77 CD 10_1101-2021_01_06_425584 530 5 , , , 10_1101-2021_01_06_425584 530 6 ( ( -LRB- 10_1101-2021_01_06_425584 530 7 10 10 CD 10_1101-2021_01_06_425584 530 8 ) ) -RRB- 10_1101-2021_01_06_425584 530 9 , , , 10_1101-2021_01_06_425584 530 10 974 974 CD 10_1101-2021_01_06_425584 530 11 - - SYM 10_1101-2021_01_06_425584 530 12 8 8 CD 10_1101-2021_01_06_425584 530 13 . . . 10_1101-2021_01_06_425584 531 1 776 776 CD 10_1101-2021_01_06_425584 531 2 73 73 CD 10_1101-2021_01_06_425584 531 3 . . . 10_1101-2021_01_06_425584 532 1 Radicioni Radicioni NNP 10_1101-2021_01_06_425584 532 2 , , , 10_1101-2021_01_06_425584 532 3 G. G. NNP 10_1101-2021_01_06_425584 532 4 ; ; : 10_1101-2021_01_06_425584 532 5 Stringaro Stringaro NNP 10_1101-2021_01_06_425584 532 6 , , , 10_1101-2021_01_06_425584 532 7 A. a. NN 10_1101-2021_01_06_425584 532 8 ; ; : 10_1101-2021_01_06_425584 532 9 Molinari Molinari NNP 10_1101-2021_01_06_425584 532 10 , , , 10_1101-2021_01_06_425584 532 11 A. a. NN 10_1101-2021_01_06_425584 532 12 ; ; : 10_1101-2021_01_06_425584 532 13 Nocca Nocca NNP 10_1101-2021_01_06_425584 532 14 , , , 10_1101-2021_01_06_425584 532 15 G. G. NNP 10_1101-2021_01_06_425584 532 16 ; ; : 10_1101-2021_01_06_425584 532 17 Longhi Longhi NNP 10_1101-2021_01_06_425584 532 18 , , , 10_1101-2021_01_06_425584 532 19 R. R. NNP 10_1101-2021_01_06_425584 532 20 ; ; : 10_1101-2021_01_06_425584 532 21 Pirolli Pirolli NNP 10_1101-2021_01_06_425584 532 22 , , , 10_1101-2021_01_06_425584 532 23 D. D. NNP 10_1101-2021_01_06_425584 532 24 ; ; : 10_1101-2021_01_06_425584 532 25 Scarano Scarano NNP 10_1101-2021_01_06_425584 532 26 , , , 10_1101-2021_01_06_425584 532 27 E. E. NNP 10_1101-2021_01_06_425584 532 28 ; ; : 10_1101-2021_01_06_425584 532 29 777 777 CD 10_1101-2021_01_06_425584 532 30 Iavarone Iavarone NNP 10_1101-2021_01_06_425584 532 31 , , , 10_1101-2021_01_06_425584 532 32 F. F. NNP 10_1101-2021_01_06_425584 532 33 ; ; : 10_1101-2021_01_06_425584 532 34 Manconi Manconi NNP 10_1101-2021_01_06_425584 532 35 , , , 10_1101-2021_01_06_425584 532 36 B. B. NNP 10_1101-2021_01_06_425584 532 37 ; ; : 10_1101-2021_01_06_425584 532 38 Cabras Cabras NNP 10_1101-2021_01_06_425584 532 39 , , , 10_1101-2021_01_06_425584 532 40 T. T. NNP 10_1101-2021_01_06_425584 532 41 ; ; : 10_1101-2021_01_06_425584 532 42 Messana Messana NNP 10_1101-2021_01_06_425584 532 43 , , , 10_1101-2021_01_06_425584 532 44 I. i. NN 10_1101-2021_01_06_425584 532 45 ; ; : 10_1101-2021_01_06_425584 532 46 Castagnola Castagnola NNP 10_1101-2021_01_06_425584 532 47 , , , 10_1101-2021_01_06_425584 532 48 M. M. NNP 10_1101-2021_01_06_425584 532 49 ; ; : 10_1101-2021_01_06_425584 532 50 Vitali Vitali NNP 10_1101-2021_01_06_425584 532 51 , , , 10_1101-2021_01_06_425584 532 52 A. A. NNP 10_1101-2021_01_06_425584 532 53 , , , 10_1101-2021_01_06_425584 532 54 Characterization Characterization NNP 10_1101-2021_01_06_425584 532 55 778 778 CD 10_1101-2021_01_06_425584 532 56 of of IN 10_1101-2021_01_06_425584 532 57 the the DT 10_1101-2021_01_06_425584 532 58 cell cell NN 10_1101-2021_01_06_425584 532 59 penetrating penetrating NN 10_1101-2021_01_06_425584 532 60 properties property NNS 10_1101-2021_01_06_425584 532 61 of of IN 10_1101-2021_01_06_425584 532 62 a a DT 10_1101-2021_01_06_425584 532 63 human human JJ 10_1101-2021_01_06_425584 532 64 salivary salivary JJ 10_1101-2021_01_06_425584 532 65 proline proline NN 10_1101-2021_01_06_425584 532 66 - - HYPH 10_1101-2021_01_06_425584 532 67 rich rich JJ 10_1101-2021_01_06_425584 532 68 peptide peptide NN 10_1101-2021_01_06_425584 532 69 . . . 10_1101-2021_01_06_425584 533 1 Biochim Biochim NNP 10_1101-2021_01_06_425584 533 2 Biophys Biophys NNP 10_1101-2021_01_06_425584 533 3 Acta Acta NNP 10_1101-2021_01_06_425584 533 4 779 779 CD 10_1101-2021_01_06_425584 533 5 2015 2015 CD 10_1101-2021_01_06_425584 533 6 , , , 10_1101-2021_01_06_425584 533 7 1848 1848 CD 10_1101-2021_01_06_425584 533 8 , , , 10_1101-2021_01_06_425584 533 9 ( ( -LRB- 10_1101-2021_01_06_425584 533 10 11 11 CD 10_1101-2021_01_06_425584 533 11 Pt Pt NNP 10_1101-2021_01_06_425584 533 12 A A NNP 10_1101-2021_01_06_425584 533 13 ) ) -RRB- 10_1101-2021_01_06_425584 533 14 , , , 10_1101-2021_01_06_425584 533 15 2868 2868 CD 10_1101-2021_01_06_425584 533 16 - - SYM 10_1101-2021_01_06_425584 533 17 77 77 CD 10_1101-2021_01_06_425584 533 18 . . . 10_1101-2021_01_06_425584 534 1 780 780 CD 10_1101-2021_01_06_425584 534 2 74 74 CD 10_1101-2021_01_06_425584 534 3 . . . 10_1101-2021_01_06_425584 535 1 Vanhoof Vanhoof NNP 10_1101-2021_01_06_425584 535 2 , , , 10_1101-2021_01_06_425584 535 3 G. G. NNP 10_1101-2021_01_06_425584 535 4 ; ; : 10_1101-2021_01_06_425584 535 5 Goossens Goossens NNP 10_1101-2021_01_06_425584 535 6 , , , 10_1101-2021_01_06_425584 535 7 F. F. NNP 10_1101-2021_01_06_425584 535 8 ; ; : 10_1101-2021_01_06_425584 535 9 De De NNP 10_1101-2021_01_06_425584 535 10 Meester Meester NNP 10_1101-2021_01_06_425584 535 11 , , , 10_1101-2021_01_06_425584 535 12 I. I. NNP 10_1101-2021_01_06_425584 535 13 ; ; : 10_1101-2021_01_06_425584 535 14 Hendriks Hendriks NNP 10_1101-2021_01_06_425584 535 15 , , , 10_1101-2021_01_06_425584 535 16 D. D. NNP 10_1101-2021_01_06_425584 535 17 ; ; : 10_1101-2021_01_06_425584 535 18 Scharpe Scharpe NNP 10_1101-2021_01_06_425584 535 19 , , , 10_1101-2021_01_06_425584 535 20 S. S. NNP 10_1101-2021_01_06_425584 535 21 , , , 10_1101-2021_01_06_425584 535 22 Proline Proline NNP 10_1101-2021_01_06_425584 535 23 motifs motif VBZ 10_1101-2021_01_06_425584 535 24 in in IN 10_1101-2021_01_06_425584 535 25 781 781 CD 10_1101-2021_01_06_425584 535 26 peptides peptide NNS 10_1101-2021_01_06_425584 535 27 and and CC 10_1101-2021_01_06_425584 535 28 their -PRON- PRP$ 10_1101-2021_01_06_425584 535 29 biological biological JJ 10_1101-2021_01_06_425584 535 30 processing processing NN 10_1101-2021_01_06_425584 535 31 . . . 10_1101-2021_01_06_425584 536 1 FASEB FASEB NNP 10_1101-2021_01_06_425584 536 2 J J NNP 10_1101-2021_01_06_425584 536 3 1995 1995 CD 10_1101-2021_01_06_425584 536 4 , , , 10_1101-2021_01_06_425584 536 5 9 9 CD 10_1101-2021_01_06_425584 536 6 , , , 10_1101-2021_01_06_425584 536 7 ( ( -LRB- 10_1101-2021_01_06_425584 536 8 9 9 CD 10_1101-2021_01_06_425584 536 9 ) ) -RRB- 10_1101-2021_01_06_425584 536 10 , , , 10_1101-2021_01_06_425584 536 11 736 736 CD 10_1101-2021_01_06_425584 536 12 - - SYM 10_1101-2021_01_06_425584 536 13 44 44 CD 10_1101-2021_01_06_425584 536 14 . . . 10_1101-2021_01_06_425584 537 1 782 782 CD 10_1101-2021_01_06_425584 537 2 75 75 CD 10_1101-2021_01_06_425584 537 3 . . . 10_1101-2021_01_06_425584 538 1 Colombo Colombo NNP 10_1101-2021_01_06_425584 538 2 , , , 10_1101-2021_01_06_425584 538 3 S. S. NNP 10_1101-2021_01_06_425584 538 4 ; ; : 10_1101-2021_01_06_425584 538 5 Melo Melo NNP 10_1101-2021_01_06_425584 538 6 , , , 10_1101-2021_01_06_425584 538 7 T. t. NN 10_1101-2021_01_06_425584 538 8 ; ; : 10_1101-2021_01_06_425584 538 9 Martinez Martinez NNP 10_1101-2021_01_06_425584 538 10 - - HYPH 10_1101-2021_01_06_425584 538 11 Lopez Lopez NNP 10_1101-2021_01_06_425584 538 12 , , , 10_1101-2021_01_06_425584 538 13 M. M. NNP 10_1101-2021_01_06_425584 538 14 ; ; : 10_1101-2021_01_06_425584 538 15 Carrasco Carrasco NNP 10_1101-2021_01_06_425584 538 16 , , , 10_1101-2021_01_06_425584 538 17 M. M. NNP 10_1101-2021_01_06_425584 538 18 J. J. NNP 10_1101-2021_01_06_425584 538 19 ; ; : 10_1101-2021_01_06_425584 538 20 Domingues Domingues NNP 10_1101-2021_01_06_425584 538 21 , , , 10_1101-2021_01_06_425584 538 22 M. M. NNP 10_1101-2021_01_06_425584 538 23 R. R. NNP 10_1101-2021_01_06_425584 538 24 ; ; : 10_1101-2021_01_06_425584 538 25 Perez-783 Perez-783 . 10_1101-2021_01_06_425584 538 26 Sala Sala NNP 10_1101-2021_01_06_425584 538 27 , , , 10_1101-2021_01_06_425584 538 28 D. D. NNP 10_1101-2021_01_06_425584 538 29 ; ; : 10_1101-2021_01_06_425584 538 30 Domingues Domingues NNP 10_1101-2021_01_06_425584 538 31 , , , 10_1101-2021_01_06_425584 538 32 P. P. NNP 10_1101-2021_01_06_425584 538 33 , , , 10_1101-2021_01_06_425584 538 34 Phospholipidome Phospholipidome NNP 10_1101-2021_01_06_425584 538 35 of of IN 10_1101-2021_01_06_425584 538 36 endothelial endothelial JJ 10_1101-2021_01_06_425584 538 37 cells cell NNS 10_1101-2021_01_06_425584 538 38 shows show VBZ 10_1101-2021_01_06_425584 538 39 a a DT 10_1101-2021_01_06_425584 538 40 different different JJ 10_1101-2021_01_06_425584 538 41 adaptation adaptation NN 10_1101-2021_01_06_425584 538 42 784 784 CD 10_1101-2021_01_06_425584 538 43 response response NN 10_1101-2021_01_06_425584 538 44 upon upon IN 10_1101-2021_01_06_425584 538 45 oxidative oxidative JJ 10_1101-2021_01_06_425584 538 46 , , , 10_1101-2021_01_06_425584 538 47 glycative glycative JJ 10_1101-2021_01_06_425584 538 48 and and CC 10_1101-2021_01_06_425584 538 49 lipoxidative lipoxidative JJ 10_1101-2021_01_06_425584 538 50 stress stress NN 10_1101-2021_01_06_425584 538 51 . . . 10_1101-2021_01_06_425584 539 1 Sci Sci NNP 10_1101-2021_01_06_425584 539 2 Rep Rep NNP 10_1101-2021_01_06_425584 539 3 2018 2018 CD 10_1101-2021_01_06_425584 539 4 , , , 10_1101-2021_01_06_425584 539 5 8 8 CD 10_1101-2021_01_06_425584 539 6 , , , 10_1101-2021_01_06_425584 539 7 ( ( -LRB- 10_1101-2021_01_06_425584 539 8 1 1 CD 10_1101-2021_01_06_425584 539 9 ) ) -RRB- 10_1101-2021_01_06_425584 539 10 , , , 10_1101-2021_01_06_425584 539 11 12365 12365 CD 10_1101-2021_01_06_425584 539 12 . . . 10_1101-2021_01_06_425584 540 1 785 785 CD 10_1101-2021_01_06_425584 540 2 76 76 CD 10_1101-2021_01_06_425584 540 3 . . . 10_1101-2021_01_06_425584 541 1 De De NNP 10_1101-2021_01_06_425584 541 2 Keyzer Keyzer NNP 10_1101-2021_01_06_425584 541 3 , , , 10_1101-2021_01_06_425584 541 4 D. D. NNP 10_1101-2021_01_06_425584 541 5 ; ; : 10_1101-2021_01_06_425584 541 6 Karabina Karabina NNP 10_1101-2021_01_06_425584 541 7 , , , 10_1101-2021_01_06_425584 541 8 S. S. NNP 10_1101-2021_01_06_425584 541 9 A. A. NNP 10_1101-2021_01_06_425584 541 10 ; ; : 10_1101-2021_01_06_425584 541 11 Wei Wei NNP 10_1101-2021_01_06_425584 541 12 , , , 10_1101-2021_01_06_425584 541 13 W. W. NNP 10_1101-2021_01_06_425584 541 14 ; ; : 10_1101-2021_01_06_425584 541 15 Geeraert Geeraert NNP 10_1101-2021_01_06_425584 541 16 , , , 10_1101-2021_01_06_425584 541 17 B. B. NNP 10_1101-2021_01_06_425584 541 18 ; ; : 10_1101-2021_01_06_425584 541 19 Stengel Stengel NNP 10_1101-2021_01_06_425584 541 20 , , , 10_1101-2021_01_06_425584 541 21 D. D. NNP 10_1101-2021_01_06_425584 541 22 ; ; : 10_1101-2021_01_06_425584 541 23 Marsillach Marsillach NNP 10_1101-2021_01_06_425584 541 24 , , , 10_1101-2021_01_06_425584 541 25 J. J. NNP 10_1101-2021_01_06_425584 541 26 ; ; : 10_1101-2021_01_06_425584 541 27 786 786 CD 10_1101-2021_01_06_425584 541 28 Camps Camps NNPS 10_1101-2021_01_06_425584 541 29 , , , 10_1101-2021_01_06_425584 541 30 J. J. NNP 10_1101-2021_01_06_425584 541 31 ; ; : 10_1101-2021_01_06_425584 541 32 Holvoet Holvoet NNP 10_1101-2021_01_06_425584 541 33 , , , 10_1101-2021_01_06_425584 541 34 P. P. NNP 10_1101-2021_01_06_425584 541 35 ; ; : 10_1101-2021_01_06_425584 541 36 Ninio Ninio NNP 10_1101-2021_01_06_425584 541 37 , , , 10_1101-2021_01_06_425584 541 38 E. E. NNP 10_1101-2021_01_06_425584 541 39 , , , 10_1101-2021_01_06_425584 541 40 Increased Increased NNP 10_1101-2021_01_06_425584 541 41 PAFAH PAFAH NNP 10_1101-2021_01_06_425584 541 42 and and CC 10_1101-2021_01_06_425584 541 43 oxidized oxidize VBN 10_1101-2021_01_06_425584 541 44 lipids lipid NNS 10_1101-2021_01_06_425584 541 45 are be VBP 10_1101-2021_01_06_425584 541 46 associated associate VBN 10_1101-2021_01_06_425584 541 47 with with IN 10_1101-2021_01_06_425584 541 48 787 787 CD 10_1101-2021_01_06_425584 541 49 inflammation inflammation NN 10_1101-2021_01_06_425584 541 50 and and CC 10_1101-2021_01_06_425584 541 51 atherosclerosis atherosclerosis NN 10_1101-2021_01_06_425584 541 52 in in IN 10_1101-2021_01_06_425584 541 53 hypercholesterolemic hypercholesterolemic JJ 10_1101-2021_01_06_425584 541 54 pigs pig NNS 10_1101-2021_01_06_425584 541 55 . . . 10_1101-2021_01_06_425584 542 1 Arterioscler Arterioscler NNP 10_1101-2021_01_06_425584 542 2 Thromb Thromb NNP 10_1101-2021_01_06_425584 542 3 Vasc Vasc NNP 10_1101-2021_01_06_425584 542 4 Biol Biol NNP 10_1101-2021_01_06_425584 542 5 788 788 CD 10_1101-2021_01_06_425584 542 6 2009 2009 CD 10_1101-2021_01_06_425584 542 7 , , , 10_1101-2021_01_06_425584 542 8 29 29 CD 10_1101-2021_01_06_425584 542 9 , , , 10_1101-2021_01_06_425584 542 10 ( ( -LRB- 10_1101-2021_01_06_425584 542 11 12 12 CD 10_1101-2021_01_06_425584 542 12 ) ) -RRB- 10_1101-2021_01_06_425584 542 13 , , , 10_1101-2021_01_06_425584 542 14 2041 2041 CD 10_1101-2021_01_06_425584 542 15 - - SYM 10_1101-2021_01_06_425584 542 16 6 6 CD 10_1101-2021_01_06_425584 542 17 . . . 10_1101-2021_01_06_425584 543 1 789 789 CD 10_1101-2021_01_06_425584 543 2 77 77 CD 10_1101-2021_01_06_425584 543 3 . . . 10_1101-2021_01_06_425584 544 1 Tselepis tselepis NN 10_1101-2021_01_06_425584 544 2 , , , 10_1101-2021_01_06_425584 544 3 A. A. NNP 10_1101-2021_01_06_425584 544 4 D. D. NNP 10_1101-2021_01_06_425584 544 5 ; ; : 10_1101-2021_01_06_425584 544 6 John John NNP 10_1101-2021_01_06_425584 544 7 Chapman Chapman NNP 10_1101-2021_01_06_425584 544 8 , , , 10_1101-2021_01_06_425584 544 9 M. M. NNP 10_1101-2021_01_06_425584 544 10 , , , 10_1101-2021_01_06_425584 544 11 Inflammation Inflammation NNP 10_1101-2021_01_06_425584 544 12 , , , 10_1101-2021_01_06_425584 544 13 bioactive bioactive JJ 10_1101-2021_01_06_425584 544 14 lipids lipid NNS 10_1101-2021_01_06_425584 544 15 and and CC 10_1101-2021_01_06_425584 544 16 atherosclerosis atherosclerosis NN 10_1101-2021_01_06_425584 544 17 : : : 10_1101-2021_01_06_425584 544 18 790 790 CD 10_1101-2021_01_06_425584 544 19 potential potential JJ 10_1101-2021_01_06_425584 544 20 roles role NNS 10_1101-2021_01_06_425584 544 21 of of IN 10_1101-2021_01_06_425584 544 22 a a DT 10_1101-2021_01_06_425584 544 23 lipoprotein lipoprotein RB 10_1101-2021_01_06_425584 544 24 - - HYPH 10_1101-2021_01_06_425584 544 25 associated associated JJ 10_1101-2021_01_06_425584 544 26 phospholipase phospholipase NN 10_1101-2021_01_06_425584 544 27 A2 a2 NN 10_1101-2021_01_06_425584 544 28 , , , 10_1101-2021_01_06_425584 544 29 platelet platelet RB 10_1101-2021_01_06_425584 544 30 activating activate VBG 10_1101-2021_01_06_425584 544 31 factor-791 factor-791 NNP 10_1101-2021_01_06_425584 544 32 acetylhydrolase acetylhydrolase NN 10_1101-2021_01_06_425584 544 33 . . . 10_1101-2021_01_06_425584 545 1 Atheroscler Atheroscler NNP 10_1101-2021_01_06_425584 545 2 Suppl Suppl NNP 10_1101-2021_01_06_425584 545 3 2002 2002 CD 10_1101-2021_01_06_425584 545 4 , , , 10_1101-2021_01_06_425584 545 5 3 3 CD 10_1101-2021_01_06_425584 545 6 , , , 10_1101-2021_01_06_425584 545 7 ( ( -LRB- 10_1101-2021_01_06_425584 545 8 4 4 CD 10_1101-2021_01_06_425584 545 9 ) ) -RRB- 10_1101-2021_01_06_425584 545 10 , , , 10_1101-2021_01_06_425584 545 11 57 57 CD 10_1101-2021_01_06_425584 545 12 - - SYM 10_1101-2021_01_06_425584 545 13 68 68 CD 10_1101-2021_01_06_425584 545 14 . . . 10_1101-2021_01_06_425584 546 1 792 792 CD 10_1101-2021_01_06_425584 546 2 78 78 CD 10_1101-2021_01_06_425584 546 3 . . . 10_1101-2021_01_06_425584 547 1 Wang Wang NNP 10_1101-2021_01_06_425584 547 2 , , , 10_1101-2021_01_06_425584 547 3 A. A. NNP 10_1101-2021_01_06_425584 547 4 ; ; : 10_1101-2021_01_06_425584 547 5 Dennis Dennis NNP 10_1101-2021_01_06_425584 547 6 , , , 10_1101-2021_01_06_425584 547 7 E. E. NNP 10_1101-2021_01_06_425584 547 8 A. A. NNP 10_1101-2021_01_06_425584 547 9 , , , 10_1101-2021_01_06_425584 547 10 Mammalian mammalian JJ 10_1101-2021_01_06_425584 547 11 lysophospholipases lysophospholipase NNS 10_1101-2021_01_06_425584 547 12 . . . 10_1101-2021_01_06_425584 548 1 Biochim Biochim NNP 10_1101-2021_01_06_425584 548 2 Biophys Biophys NNP 10_1101-2021_01_06_425584 548 3 Acta Acta NNP 10_1101-2021_01_06_425584 548 4 1999 1999 CD 10_1101-2021_01_06_425584 548 5 , , , 10_1101-2021_01_06_425584 548 6 793 793 CD 10_1101-2021_01_06_425584 548 7 1439 1439 CD 10_1101-2021_01_06_425584 548 8 , , , 10_1101-2021_01_06_425584 548 9 ( ( -LRB- 10_1101-2021_01_06_425584 548 10 1 1 CD 10_1101-2021_01_06_425584 548 11 ) ) -RRB- 10_1101-2021_01_06_425584 548 12 , , , 10_1101-2021_01_06_425584 548 13 1 1 CD 10_1101-2021_01_06_425584 548 14 - - SYM 10_1101-2021_01_06_425584 548 15 16 16 CD 10_1101-2021_01_06_425584 548 16 . . . 10_1101-2021_01_06_425584 549 1 794 794 CD 10_1101-2021_01_06_425584 549 2 79 79 CD 10_1101-2021_01_06_425584 549 3 . . . 10_1101-2021_01_06_425584 550 1 Marco Marco NNP 10_1101-2021_01_06_425584 550 2 - - HYPH 10_1101-2021_01_06_425584 550 3 Ramell Ramell NNP 10_1101-2021_01_06_425584 550 4 , , , 10_1101-2021_01_06_425584 550 5 A. a. NN 10_1101-2021_01_06_425584 550 6 ; ; : 10_1101-2021_01_06_425584 550 7 Palau Palau NNP 10_1101-2021_01_06_425584 550 8 - - HYPH 10_1101-2021_01_06_425584 550 9 Rodriguez Rodriguez NNP 10_1101-2021_01_06_425584 550 10 , , , 10_1101-2021_01_06_425584 550 11 M. M. NNP 10_1101-2021_01_06_425584 550 12 ; ; : 10_1101-2021_01_06_425584 550 13 Alay Alay NNP 10_1101-2021_01_06_425584 550 14 , , , 10_1101-2021_01_06_425584 550 15 A. a. NN 10_1101-2021_01_06_425584 550 16 ; ; : 10_1101-2021_01_06_425584 550 17 Tulipani Tulipani NNP 10_1101-2021_01_06_425584 550 18 , , , 10_1101-2021_01_06_425584 550 19 S. S. NNP 10_1101-2021_01_06_425584 550 20 ; ; : 10_1101-2021_01_06_425584 550 21 Urpi Urpi NNP 10_1101-2021_01_06_425584 550 22 - - HYPH 10_1101-2021_01_06_425584 550 23 Sarda Sarda NNP 10_1101-2021_01_06_425584 550 24 , , , 10_1101-2021_01_06_425584 550 25 M. M. NNP 10_1101-2021_01_06_425584 550 26 ; ; : 10_1101-2021_01_06_425584 550 27 Sanchez-795 Sanchez-795 . 10_1101-2021_01_06_425584 550 28 Pla Pla NNP 10_1101-2021_01_06_425584 550 29 , , , 10_1101-2021_01_06_425584 550 30 A. a. NN 10_1101-2021_01_06_425584 550 31 ; ; : 10_1101-2021_01_06_425584 550 32 Andres Andres NNP 10_1101-2021_01_06_425584 550 33 - - HYPH 10_1101-2021_01_06_425584 550 34 Lacueva Lacueva NNP 10_1101-2021_01_06_425584 550 35 , , , 10_1101-2021_01_06_425584 550 36 C. C. NNP 10_1101-2021_01_06_425584 550 37 , , , 10_1101-2021_01_06_425584 550 38 Evaluation Evaluation NNP 10_1101-2021_01_06_425584 550 39 and and CC 10_1101-2021_01_06_425584 550 40 comparison comparison NN 10_1101-2021_01_06_425584 550 41 of of IN 10_1101-2021_01_06_425584 550 42 bioinformatic bioinformatic JJ 10_1101-2021_01_06_425584 550 43 tools tool NNS 10_1101-2021_01_06_425584 550 44 for for IN 10_1101-2021_01_06_425584 550 45 the the DT 10_1101-2021_01_06_425584 550 46 796 796 CD 10_1101-2021_01_06_425584 550 47 enrichment enrichment NN 10_1101-2021_01_06_425584 550 48 analysis analysis NN 10_1101-2021_01_06_425584 550 49 of of IN 10_1101-2021_01_06_425584 550 50 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 550 51 data datum NNS 10_1101-2021_01_06_425584 550 52 . . . 10_1101-2021_01_06_425584 551 1 BMC BMC NNP 10_1101-2021_01_06_425584 551 2 Bioinformatics Bioinformatics NNP 10_1101-2021_01_06_425584 551 3 2018 2018 CD 10_1101-2021_01_06_425584 551 4 , , , 10_1101-2021_01_06_425584 551 5 19 19 CD 10_1101-2021_01_06_425584 551 6 , , , 10_1101-2021_01_06_425584 551 7 ( ( -LRB- 10_1101-2021_01_06_425584 551 8 1 1 CD 10_1101-2021_01_06_425584 551 9 ) ) -RRB- 10_1101-2021_01_06_425584 551 10 , , , 10_1101-2021_01_06_425584 551 11 1 1 CD 10_1101-2021_01_06_425584 551 12 . . . 10_1101-2021_01_06_425584 552 1 797 797 CD 10_1101-2021_01_06_425584 552 2 80 80 CD 10_1101-2021_01_06_425584 552 3 . . . 10_1101-2021_01_06_425584 553 1 Zhou Zhou NNP 10_1101-2021_01_06_425584 553 2 , , , 10_1101-2021_01_06_425584 553 3 X. X. NNP 10_1101-2021_01_06_425584 553 4 ; ; : 10_1101-2021_01_06_425584 553 5 Liao Liao NNP 10_1101-2021_01_06_425584 553 6 , , , 10_1101-2021_01_06_425584 553 7 W. W. NNP 10_1101-2021_01_06_425584 553 8 J. J. NNP 10_1101-2021_01_06_425584 553 9 ; ; : 10_1101-2021_01_06_425584 553 10 Liao Liao NNP 10_1101-2021_01_06_425584 553 11 , , , 10_1101-2021_01_06_425584 553 12 J. J. NNP 10_1101-2021_01_06_425584 553 13 M. M. NNP 10_1101-2021_01_06_425584 553 14 ; ; : 10_1101-2021_01_06_425584 553 15 Liao Liao NNP 10_1101-2021_01_06_425584 553 16 , , , 10_1101-2021_01_06_425584 553 17 P. P. NNP 10_1101-2021_01_06_425584 553 18 ; ; : 10_1101-2021_01_06_425584 553 19 Lu Lu NNP 10_1101-2021_01_06_425584 553 20 , , , 10_1101-2021_01_06_425584 553 21 H. H. NNP 10_1101-2021_01_06_425584 553 22 , , , 10_1101-2021_01_06_425584 553 23 Ribosomal Ribosomal NNP 10_1101-2021_01_06_425584 553 24 proteins protein NNS 10_1101-2021_01_06_425584 553 25 : : : 10_1101-2021_01_06_425584 553 26 functions function NNS 10_1101-2021_01_06_425584 553 27 beyond beyond IN 10_1101-2021_01_06_425584 553 28 798 798 CD 10_1101-2021_01_06_425584 553 29 the the DT 10_1101-2021_01_06_425584 553 30 ribosome ribosome NN 10_1101-2021_01_06_425584 553 31 . . . 10_1101-2021_01_06_425584 554 1 J J NNP 10_1101-2021_01_06_425584 554 2 Mol Mol NNP 10_1101-2021_01_06_425584 554 3 Cell Cell NNP 10_1101-2021_01_06_425584 554 4 Biol Biol NNP 10_1101-2021_01_06_425584 554 5 2015 2015 CD 10_1101-2021_01_06_425584 554 6 , , , 10_1101-2021_01_06_425584 554 7 7 7 CD 10_1101-2021_01_06_425584 554 8 , , , 10_1101-2021_01_06_425584 554 9 ( ( -LRB- 10_1101-2021_01_06_425584 554 10 2 2 CD 10_1101-2021_01_06_425584 554 11 ) ) -RRB- 10_1101-2021_01_06_425584 554 12 , , , 10_1101-2021_01_06_425584 554 13 92 92 CD 10_1101-2021_01_06_425584 554 14 - - HYPH 10_1101-2021_01_06_425584 554 15 104 104 CD 10_1101-2021_01_06_425584 554 16 . . . 10_1101-2021_01_06_425584 555 1 799 799 CD 10_1101-2021_01_06_425584 555 2 81 81 CD 10_1101-2021_01_06_425584 555 3 . . . 10_1101-2021_01_06_425584 556 1 Goldberg Goldberg NNP 10_1101-2021_01_06_425584 556 2 , , , 10_1101-2021_01_06_425584 556 3 A. A. NNP 10_1101-2021_01_06_425584 556 4 L. L. NNP 10_1101-2021_01_06_425584 556 5 , , , 10_1101-2021_01_06_425584 556 6 Protein Protein NNP 10_1101-2021_01_06_425584 556 7 degradation degradation NN 10_1101-2021_01_06_425584 556 8 and and CC 10_1101-2021_01_06_425584 556 9 protection protection NN 10_1101-2021_01_06_425584 556 10 against against IN 10_1101-2021_01_06_425584 556 11 misfolded misfolde VBN 10_1101-2021_01_06_425584 556 12 or or CC 10_1101-2021_01_06_425584 556 13 damaged damage VBN 10_1101-2021_01_06_425584 556 14 800 800 CD 10_1101-2021_01_06_425584 556 15 proteins protein NNS 10_1101-2021_01_06_425584 556 16 . . . 10_1101-2021_01_06_425584 557 1 Nature nature NN 10_1101-2021_01_06_425584 557 2 2003 2003 CD 10_1101-2021_01_06_425584 557 3 , , , 10_1101-2021_01_06_425584 557 4 426 426 CD 10_1101-2021_01_06_425584 557 5 , , , 10_1101-2021_01_06_425584 557 6 ( ( -LRB- 10_1101-2021_01_06_425584 557 7 6968 6968 CD 10_1101-2021_01_06_425584 557 8 ) ) -RRB- 10_1101-2021_01_06_425584 557 9 , , , 10_1101-2021_01_06_425584 557 10 895 895 CD 10_1101-2021_01_06_425584 557 11 - - SYM 10_1101-2021_01_06_425584 557 12 9 9 CD 10_1101-2021_01_06_425584 557 13 . . . 10_1101-2021_01_06_425584 558 1 801 801 CD 10_1101-2021_01_06_425584 558 2 82 82 CD 10_1101-2021_01_06_425584 558 3 . . . 10_1101-2021_01_06_425584 559 1 Vinals vinal NNS 10_1101-2021_01_06_425584 559 2 , , , 10_1101-2021_01_06_425584 559 3 F. F. NNP 10_1101-2021_01_06_425584 559 4 ; ; : 10_1101-2021_01_06_425584 559 5 Pouyssegur Pouyssegur NNP 10_1101-2021_01_06_425584 559 6 , , , 10_1101-2021_01_06_425584 559 7 J. J. NNP 10_1101-2021_01_06_425584 559 8 , , , 10_1101-2021_01_06_425584 559 9 Confluence Confluence NNP 10_1101-2021_01_06_425584 559 10 of of IN 10_1101-2021_01_06_425584 559 11 vascular vascular JJ 10_1101-2021_01_06_425584 559 12 endothelial endothelial JJ 10_1101-2021_01_06_425584 559 13 cells cell NNS 10_1101-2021_01_06_425584 559 14 induces induce VBZ 10_1101-2021_01_06_425584 559 15 cell cell NN 10_1101-2021_01_06_425584 559 16 cycle cycle NN 10_1101-2021_01_06_425584 559 17 802 802 CD 10_1101-2021_01_06_425584 559 18 exit exit NN 10_1101-2021_01_06_425584 559 19 by by IN 10_1101-2021_01_06_425584 559 20 inhibiting inhibit VBG 10_1101-2021_01_06_425584 559 21 p42 p42 NN 10_1101-2021_01_06_425584 559 22 / / SYM 10_1101-2021_01_06_425584 559 23 p44 p44 NNP 10_1101-2021_01_06_425584 559 24 mitogen mitogen NN 10_1101-2021_01_06_425584 559 25 - - HYPH 10_1101-2021_01_06_425584 559 26 activated activate VBN 10_1101-2021_01_06_425584 559 27 protein protein NN 10_1101-2021_01_06_425584 559 28 kinase kinase NN 10_1101-2021_01_06_425584 559 29 activity activity NN 10_1101-2021_01_06_425584 559 30 . . . 10_1101-2021_01_06_425584 560 1 Mol Mol NNP 10_1101-2021_01_06_425584 560 2 Cell Cell NNP 10_1101-2021_01_06_425584 560 3 Biol Biol NNP 10_1101-2021_01_06_425584 560 4 1999 1999 CD 10_1101-2021_01_06_425584 560 5 , , , 10_1101-2021_01_06_425584 560 6 19 19 CD 10_1101-2021_01_06_425584 560 7 , , , 10_1101-2021_01_06_425584 560 8 ( ( -LRB- 10_1101-2021_01_06_425584 560 9 4 4 CD 10_1101-2021_01_06_425584 560 10 ) ) -RRB- 10_1101-2021_01_06_425584 560 11 , , , 10_1101-2021_01_06_425584 560 12 803 803 CD 10_1101-2021_01_06_425584 560 13 2763 2763 CD 10_1101-2021_01_06_425584 560 14 - - SYM 10_1101-2021_01_06_425584 560 15 72 72 CD 10_1101-2021_01_06_425584 560 16 . . . 10_1101-2021_01_06_425584 561 1 804 804 CD 10_1101-2021_01_06_425584 561 2 83 83 CD 10_1101-2021_01_06_425584 561 3 . . . 10_1101-2021_01_06_425584 562 1 Yu Yu NNP 10_1101-2021_01_06_425584 562 2 , , , 10_1101-2021_01_06_425584 562 3 Y. Y. NNP 10_1101-2021_01_06_425584 562 4 ; ; : 10_1101-2021_01_06_425584 562 5 Moulton Moulton NNP 10_1101-2021_01_06_425584 562 6 , , , 10_1101-2021_01_06_425584 562 7 K. K. NNP 10_1101-2021_01_06_425584 562 8 S. S. NNP 10_1101-2021_01_06_425584 562 9 ; ; : 10_1101-2021_01_06_425584 562 10 Khan Khan NNP 10_1101-2021_01_06_425584 562 11 , , , 10_1101-2021_01_06_425584 562 12 M. M. NNP 10_1101-2021_01_06_425584 562 13 K. K. NNP 10_1101-2021_01_06_425584 562 14 ; ; : 10_1101-2021_01_06_425584 562 15 Vineberg Vineberg NNP 10_1101-2021_01_06_425584 562 16 , , , 10_1101-2021_01_06_425584 562 17 S. S. NNP 10_1101-2021_01_06_425584 562 18 ; ; : 10_1101-2021_01_06_425584 562 19 Boye Boye NNP 10_1101-2021_01_06_425584 562 20 , , , 10_1101-2021_01_06_425584 562 21 E. E. NNP 10_1101-2021_01_06_425584 562 22 ; ; : 10_1101-2021_01_06_425584 562 23 Davis Davis NNP 10_1101-2021_01_06_425584 562 24 , , , 10_1101-2021_01_06_425584 562 25 V. V. NNP 10_1101-2021_01_06_425584 562 26 M. M. NNP 10_1101-2021_01_06_425584 562 27 ; ; : 10_1101-2021_01_06_425584 562 28 O'Donnell O'Donnell NNP 10_1101-2021_01_06_425584 562 29 , , , 10_1101-2021_01_06_425584 562 30 P. P. NNP 10_1101-2021_01_06_425584 562 31 805 805 CD 10_1101-2021_01_06_425584 562 32 E. E. NNP 10_1101-2021_01_06_425584 562 33 ; ; : 10_1101-2021_01_06_425584 562 34 Bischoff Bischoff NNP 10_1101-2021_01_06_425584 562 35 , , , 10_1101-2021_01_06_425584 562 36 J. J. NNP 10_1101-2021_01_06_425584 562 37 ; ; : 10_1101-2021_01_06_425584 562 38 Milstone Milstone NNP 10_1101-2021_01_06_425584 562 39 , , , 10_1101-2021_01_06_425584 562 40 D. D. NNP 10_1101-2021_01_06_425584 562 41 S. S. NNP 10_1101-2021_01_06_425584 562 42 , , , 10_1101-2021_01_06_425584 562 43 E E NNP 10_1101-2021_01_06_425584 562 44 - - NN 10_1101-2021_01_06_425584 562 45 selectin selectin NN 10_1101-2021_01_06_425584 562 46 is be VBZ 10_1101-2021_01_06_425584 562 47 required require VBN 10_1101-2021_01_06_425584 562 48 for for IN 10_1101-2021_01_06_425584 562 49 the the DT 10_1101-2021_01_06_425584 562 50 antiangiogenic antiangiogenic JJ 10_1101-2021_01_06_425584 562 51 activity activity NN 10_1101-2021_01_06_425584 562 52 of of IN 10_1101-2021_01_06_425584 562 53 806 806 CD 10_1101-2021_01_06_425584 562 54 endostatin endostatin NNS 10_1101-2021_01_06_425584 562 55 . . . 10_1101-2021_01_06_425584 563 1 Proc Proc NNP 10_1101-2021_01_06_425584 563 2 Natl Natl NNP 10_1101-2021_01_06_425584 563 3 Acad Acad NNP 10_1101-2021_01_06_425584 563 4 Sci Sci NNP 10_1101-2021_01_06_425584 563 5 U U NNP 10_1101-2021_01_06_425584 563 6 S S NNP 10_1101-2021_01_06_425584 563 7 A A NNP 10_1101-2021_01_06_425584 563 8 2004 2004 CD 10_1101-2021_01_06_425584 563 9 , , , 10_1101-2021_01_06_425584 563 10 101 101 CD 10_1101-2021_01_06_425584 563 11 , , , 10_1101-2021_01_06_425584 563 12 ( ( -LRB- 10_1101-2021_01_06_425584 563 13 21 21 CD 10_1101-2021_01_06_425584 563 14 ) ) -RRB- 10_1101-2021_01_06_425584 563 15 , , , 10_1101-2021_01_06_425584 563 16 8005 8005 CD 10_1101-2021_01_06_425584 563 17 - - SYM 10_1101-2021_01_06_425584 563 18 10 10 CD 10_1101-2021_01_06_425584 563 19 . . . 10_1101-2021_01_06_425584 564 1 807 807 CD 10_1101-2021_01_06_425584 564 2 84 84 CD 10_1101-2021_01_06_425584 564 3 . . . 10_1101-2021_01_06_425584 565 1 Brigstock Brigstock NNP 10_1101-2021_01_06_425584 565 2 , , , 10_1101-2021_01_06_425584 565 3 D. D. NNP 10_1101-2021_01_06_425584 565 4 R. R. NNP 10_1101-2021_01_06_425584 565 5 , , , 10_1101-2021_01_06_425584 565 6 Regulation Regulation NNP 10_1101-2021_01_06_425584 565 7 of of IN 10_1101-2021_01_06_425584 565 8 angiogenesis angiogenesis NN 10_1101-2021_01_06_425584 565 9 and and CC 10_1101-2021_01_06_425584 565 10 endothelial endothelial JJ 10_1101-2021_01_06_425584 565 11 cell cell NN 10_1101-2021_01_06_425584 565 12 function function NN 10_1101-2021_01_06_425584 565 13 by by IN 10_1101-2021_01_06_425584 565 14 connective connective JJ 10_1101-2021_01_06_425584 565 15 808 808 CD 10_1101-2021_01_06_425584 565 16 tissue tissue NN 10_1101-2021_01_06_425584 565 17 growth growth NN 10_1101-2021_01_06_425584 565 18 factor factor NN 10_1101-2021_01_06_425584 565 19 ( ( -LRB- 10_1101-2021_01_06_425584 565 20 CTGF CTGF NNP 10_1101-2021_01_06_425584 565 21 ) ) -RRB- 10_1101-2021_01_06_425584 565 22 and and CC 10_1101-2021_01_06_425584 565 23 cysteine cysteine NN 10_1101-2021_01_06_425584 565 24 - - HYPH 10_1101-2021_01_06_425584 565 25 rich rich JJ 10_1101-2021_01_06_425584 565 26 61 61 CD 10_1101-2021_01_06_425584 565 27 ( ( -LRB- 10_1101-2021_01_06_425584 565 28 CYR61 CYR61 NNP 10_1101-2021_01_06_425584 565 29 ) ) -RRB- 10_1101-2021_01_06_425584 565 30 . . . 10_1101-2021_01_06_425584 566 1 Angiogenesis Angiogenesis NNP 10_1101-2021_01_06_425584 566 2 2002 2002 CD 10_1101-2021_01_06_425584 566 3 , , , 10_1101-2021_01_06_425584 566 4 5 5 CD 10_1101-2021_01_06_425584 566 5 , , , 10_1101-2021_01_06_425584 566 6 ( ( -LRB- 10_1101-2021_01_06_425584 566 7 3 3 CD 10_1101-2021_01_06_425584 566 8 ) ) -RRB- 10_1101-2021_01_06_425584 566 9 , , , 10_1101-2021_01_06_425584 566 10 153 153 CD 10_1101-2021_01_06_425584 566 11 - - SYM 10_1101-2021_01_06_425584 566 12 65 65 CD 10_1101-2021_01_06_425584 566 13 . . . 10_1101-2021_01_06_425584 567 1 809 809 CD 10_1101-2021_01_06_425584 567 2 85 85 CD 10_1101-2021_01_06_425584 567 3 . . . 10_1101-2021_01_06_425584 568 1 Elmasri Elmasri NNP 10_1101-2021_01_06_425584 568 2 , , , 10_1101-2021_01_06_425584 568 3 H. H. NNP 10_1101-2021_01_06_425584 568 4 ; ; : 10_1101-2021_01_06_425584 568 5 Ghelfi Ghelfi NNP 10_1101-2021_01_06_425584 568 6 , , , 10_1101-2021_01_06_425584 568 7 E. E. NNP 10_1101-2021_01_06_425584 568 8 ; ; : 10_1101-2021_01_06_425584 568 9 Yu Yu NNP 10_1101-2021_01_06_425584 568 10 , , , 10_1101-2021_01_06_425584 568 11 C. C. NNP 10_1101-2021_01_06_425584 568 12 W. W. NNP 10_1101-2021_01_06_425584 568 13 ; ; : 10_1101-2021_01_06_425584 568 14 Traphagen Traphagen NNP 10_1101-2021_01_06_425584 568 15 , , , 10_1101-2021_01_06_425584 568 16 S. S. NNP 10_1101-2021_01_06_425584 568 17 ; ; : 10_1101-2021_01_06_425584 568 18 Cernadas Cernadas NNP 10_1101-2021_01_06_425584 568 19 , , , 10_1101-2021_01_06_425584 568 20 M. M. NNP 10_1101-2021_01_06_425584 568 21 ; ; : 10_1101-2021_01_06_425584 568 22 Cao Cao NNP 10_1101-2021_01_06_425584 568 23 , , , 10_1101-2021_01_06_425584 568 24 H. H. NNP 10_1101-2021_01_06_425584 568 25 ; ; : 10_1101-2021_01_06_425584 568 26 Shi Shi NNP 10_1101-2021_01_06_425584 568 27 , , , 10_1101-2021_01_06_425584 568 28 G. G. NNP 10_1101-2021_01_06_425584 568 29 P. P. NNP 10_1101-2021_01_06_425584 568 30 ; ; : 10_1101-2021_01_06_425584 568 31 810 810 CD 10_1101-2021_01_06_425584 568 32 Plutzky Plutzky NNP 10_1101-2021_01_06_425584 568 33 , , , 10_1101-2021_01_06_425584 568 34 J. J. NNP 10_1101-2021_01_06_425584 568 35 ; ; : 10_1101-2021_01_06_425584 568 36 Sahin Sahin NNP 10_1101-2021_01_06_425584 568 37 , , , 10_1101-2021_01_06_425584 568 38 M. M. NNP 10_1101-2021_01_06_425584 568 39 ; ; : 10_1101-2021_01_06_425584 568 40 Hotamisligil Hotamisligil NNP 10_1101-2021_01_06_425584 568 41 , , , 10_1101-2021_01_06_425584 568 42 G. G. NNP 10_1101-2021_01_06_425584 568 43 ; ; : 10_1101-2021_01_06_425584 568 44 Cataltepe Cataltepe NNP 10_1101-2021_01_06_425584 568 45 , , , 10_1101-2021_01_06_425584 568 46 S. S. NNP 10_1101-2021_01_06_425584 568 47 , , , 10_1101-2021_01_06_425584 568 48 Endothelial endothelial JJ 10_1101-2021_01_06_425584 568 49 cell cell NN 10_1101-2021_01_06_425584 568 50 - - HYPH 10_1101-2021_01_06_425584 568 51 fatty fatty NN 10_1101-2021_01_06_425584 568 52 acid acid NN 10_1101-2021_01_06_425584 568 53 binding bind VBG 10_1101-2021_01_06_425584 568 54 protein protein NN 10_1101-2021_01_06_425584 568 55 4 4 CD 10_1101-2021_01_06_425584 568 56 811 811 CD 10_1101-2021_01_06_425584 568 57 promotes promote NNS 10_1101-2021_01_06_425584 568 58 angiogenesis angiogenesis NN 10_1101-2021_01_06_425584 568 59 : : : 10_1101-2021_01_06_425584 568 60 role role NN 10_1101-2021_01_06_425584 568 61 of of IN 10_1101-2021_01_06_425584 568 62 stem stem NN 10_1101-2021_01_06_425584 568 63 cell cell NN 10_1101-2021_01_06_425584 568 64 factor factor NN 10_1101-2021_01_06_425584 568 65 / / SYM 10_1101-2021_01_06_425584 568 66 c c NNP 10_1101-2021_01_06_425584 568 67 - - HYPH 10_1101-2021_01_06_425584 568 68 kit kit NN 10_1101-2021_01_06_425584 568 69 pathway pathway NN 10_1101-2021_01_06_425584 568 70 . . . 10_1101-2021_01_06_425584 569 1 Angiogenesis Angiogenesis NNP 10_1101-2021_01_06_425584 569 2 2012 2012 CD 10_1101-2021_01_06_425584 569 3 , , , 10_1101-2021_01_06_425584 569 4 15 15 CD 10_1101-2021_01_06_425584 569 5 , , , 10_1101-2021_01_06_425584 569 6 ( ( -LRB- 10_1101-2021_01_06_425584 569 7 3 3 CD 10_1101-2021_01_06_425584 569 8 ) ) -RRB- 10_1101-2021_01_06_425584 569 9 , , , 10_1101-2021_01_06_425584 569 10 457 457 CD 10_1101-2021_01_06_425584 569 11 - - SYM 10_1101-2021_01_06_425584 569 12 812 812 CD 10_1101-2021_01_06_425584 569 13 68 68 CD 10_1101-2021_01_06_425584 569 14 . . . 10_1101-2021_01_06_425584 570 1 813 813 CD 10_1101-2021_01_06_425584 570 2 86 86 CD 10_1101-2021_01_06_425584 570 3 . . . 10_1101-2021_01_06_425584 571 1 Quinn Quinn NNP 10_1101-2021_01_06_425584 571 2 , , , 10_1101-2021_01_06_425584 571 3 M. M. NNP 10_1101-2021_01_06_425584 571 4 T. T. NNP 10_1101-2021_01_06_425584 571 5 ; ; : 10_1101-2021_01_06_425584 571 6 Schepetkin Schepetkin NNP 10_1101-2021_01_06_425584 571 7 , , , 10_1101-2021_01_06_425584 571 8 I. i. NN 10_1101-2021_01_06_425584 572 1 A. A. NNP 10_1101-2021_01_06_425584 572 2 , , , 10_1101-2021_01_06_425584 572 3 Role Role NNP 10_1101-2021_01_06_425584 572 4 of of IN 10_1101-2021_01_06_425584 572 5 NADPH NADPH NNP 10_1101-2021_01_06_425584 572 6 oxidase oxidase NN 10_1101-2021_01_06_425584 572 7 in in IN 10_1101-2021_01_06_425584 572 8 formation formation NN 10_1101-2021_01_06_425584 572 9 and and CC 10_1101-2021_01_06_425584 572 10 function function NN 10_1101-2021_01_06_425584 572 11 of of IN 10_1101-2021_01_06_425584 572 12 814 814 CD 10_1101-2021_01_06_425584 572 13 multinucleated multinucleated JJ 10_1101-2021_01_06_425584 572 14 giant giant JJ 10_1101-2021_01_06_425584 572 15 cells cell NNS 10_1101-2021_01_06_425584 572 16 . . . 10_1101-2021_01_06_425584 573 1 J J NNP 10_1101-2021_01_06_425584 573 2 Innate Innate NNP 10_1101-2021_01_06_425584 573 3 Immun Immun NNP 10_1101-2021_01_06_425584 573 4 2009 2009 CD 10_1101-2021_01_06_425584 573 5 , , , 10_1101-2021_01_06_425584 573 6 1 1 CD 10_1101-2021_01_06_425584 573 7 , , , 10_1101-2021_01_06_425584 573 8 ( ( -LRB- 10_1101-2021_01_06_425584 573 9 6 6 CD 10_1101-2021_01_06_425584 573 10 ) ) -RRB- 10_1101-2021_01_06_425584 573 11 , , , 10_1101-2021_01_06_425584 573 12 509 509 CD 10_1101-2021_01_06_425584 573 13 - - SYM 10_1101-2021_01_06_425584 573 14 26 26 CD 10_1101-2021_01_06_425584 573 15 . . . 10_1101-2021_01_06_425584 574 1 815 815 CD 10_1101-2021_01_06_425584 574 2 87 87 CD 10_1101-2021_01_06_425584 574 3 . . . 10_1101-2021_01_06_425584 575 1 Holt Holt NNP 10_1101-2021_01_06_425584 575 2 , , , 10_1101-2021_01_06_425584 575 3 D. D. NNP 10_1101-2021_01_06_425584 575 4 J. J. NNP 10_1101-2021_01_06_425584 575 5 ; ; : 10_1101-2021_01_06_425584 575 6 Grainger Grainger NNP 10_1101-2021_01_06_425584 575 7 , , , 10_1101-2021_01_06_425584 575 8 D. D. NNP 10_1101-2021_01_06_425584 575 9 W. W. NNP 10_1101-2021_01_06_425584 575 10 , , , 10_1101-2021_01_06_425584 575 11 Multinucleated multinucleated JJ 10_1101-2021_01_06_425584 575 12 giant giant JJ 10_1101-2021_01_06_425584 575 13 cells cell NNS 10_1101-2021_01_06_425584 575 14 from from IN 10_1101-2021_01_06_425584 575 15 fibroblast fibroblast NN 10_1101-2021_01_06_425584 575 16 cultures culture NNS 10_1101-2021_01_06_425584 575 17 . . . 10_1101-2021_01_06_425584 576 1 816 816 CD 10_1101-2021_01_06_425584 576 2 Biomaterials Biomaterials NNP 10_1101-2021_01_06_425584 576 3 2011 2011 CD 10_1101-2021_01_06_425584 576 4 , , , 10_1101-2021_01_06_425584 576 5 32 32 CD 10_1101-2021_01_06_425584 576 6 , , , 10_1101-2021_01_06_425584 576 7 ( ( -LRB- 10_1101-2021_01_06_425584 576 8 16 16 CD 10_1101-2021_01_06_425584 576 9 ) ) -RRB- 10_1101-2021_01_06_425584 576 10 , , , 10_1101-2021_01_06_425584 576 11 3977 3977 CD 10_1101-2021_01_06_425584 576 12 - - SYM 10_1101-2021_01_06_425584 576 13 87 87 CD 10_1101-2021_01_06_425584 576 14 . . . 10_1101-2021_01_06_425584 577 1 817 817 CD 10_1101-2021_01_06_425584 577 2 88 88 CD 10_1101-2021_01_06_425584 577 3 . . . 10_1101-2021_01_06_425584 578 1 Tse Tse NNP 10_1101-2021_01_06_425584 578 2 , , , 10_1101-2021_01_06_425584 578 3 G. G. NNP 10_1101-2021_01_06_425584 578 4 M. M. NNP 10_1101-2021_01_06_425584 578 5 ; ; : 10_1101-2021_01_06_425584 578 6 Law Law NNP 10_1101-2021_01_06_425584 578 7 , , , 10_1101-2021_01_06_425584 578 8 B. B. NNP 10_1101-2021_01_06_425584 578 9 K. K. NNP 10_1101-2021_01_06_425584 578 10 ; ; : 10_1101-2021_01_06_425584 578 11 Chan Chan NNP 10_1101-2021_01_06_425584 578 12 , , , 10_1101-2021_01_06_425584 578 13 K. K. NNP 10_1101-2021_01_06_425584 578 14 F. F. NNP 10_1101-2021_01_06_425584 578 15 ; ; : 10_1101-2021_01_06_425584 578 16 Mas Mas NNP 10_1101-2021_01_06_425584 578 17 , , , 10_1101-2021_01_06_425584 578 18 T. T. NNP 10_1101-2021_01_06_425584 578 19 K. K. NNP 10_1101-2021_01_06_425584 578 20 , , , 10_1101-2021_01_06_425584 578 21 Multinucleated Multinucleated NNP 10_1101-2021_01_06_425584 578 22 stromal stromal VBP 10_1101-2021_01_06_425584 578 23 giant giant JJ 10_1101-2021_01_06_425584 578 24 cells cell NNS 10_1101-2021_01_06_425584 578 25 in in IN 10_1101-2021_01_06_425584 578 26 818 818 CD 10_1101-2021_01_06_425584 578 27 mammary mammary JJ 10_1101-2021_01_06_425584 578 28 phyllodes phyllode NNS 10_1101-2021_01_06_425584 578 29 tumours tumour NNS 10_1101-2021_01_06_425584 578 30 . . . 10_1101-2021_01_06_425584 579 1 Pathology pathology NN 10_1101-2021_01_06_425584 579 2 2001 2001 CD 10_1101-2021_01_06_425584 579 3 , , , 10_1101-2021_01_06_425584 579 4 33 33 CD 10_1101-2021_01_06_425584 579 5 , , , 10_1101-2021_01_06_425584 579 6 ( ( -LRB- 10_1101-2021_01_06_425584 579 7 2 2 CD 10_1101-2021_01_06_425584 579 8 ) ) -RRB- 10_1101-2021_01_06_425584 579 9 , , , 10_1101-2021_01_06_425584 579 10 153 153 CD 10_1101-2021_01_06_425584 579 11 - - SYM 10_1101-2021_01_06_425584 579 12 6 6 CD 10_1101-2021_01_06_425584 579 13 . . . 10_1101-2021_01_06_425584 580 1 819 819 CD 10_1101-2021_01_06_425584 580 2 89 89 CD 10_1101-2021_01_06_425584 580 3 . . . 10_1101-2021_01_06_425584 581 1 Celton Celton NNP 10_1101-2021_01_06_425584 581 2 - - HYPH 10_1101-2021_01_06_425584 581 3 Morizur Morizur NNP 10_1101-2021_01_06_425584 581 4 , , , 10_1101-2021_01_06_425584 581 5 S. S. NNP 10_1101-2021_01_06_425584 581 6 ; ; : 10_1101-2021_01_06_425584 581 7 Merlen Merlen NNP 10_1101-2021_01_06_425584 581 8 , , , 10_1101-2021_01_06_425584 581 9 G. G. NNP 10_1101-2021_01_06_425584 581 10 ; ; : 10_1101-2021_01_06_425584 581 11 Couton Couton NNP 10_1101-2021_01_06_425584 581 12 , , , 10_1101-2021_01_06_425584 581 13 D. D. NNP 10_1101-2021_01_06_425584 581 14 ; ; : 10_1101-2021_01_06_425584 581 15 Desdouets Desdouets NNP 10_1101-2021_01_06_425584 581 16 , , , 10_1101-2021_01_06_425584 581 17 C. C. NNP 10_1101-2021_01_06_425584 581 18 , , , 10_1101-2021_01_06_425584 581 19 Polyploidy Polyploidy NNP 10_1101-2021_01_06_425584 581 20 and and CC 10_1101-2021_01_06_425584 581 21 liver liver NN 10_1101-2021_01_06_425584 581 22 820 820 CD 10_1101-2021_01_06_425584 581 23 proliferation proliferation NN 10_1101-2021_01_06_425584 581 24 : : : 10_1101-2021_01_06_425584 581 25 central central JJ 10_1101-2021_01_06_425584 581 26 role role NN 10_1101-2021_01_06_425584 581 27 of of IN 10_1101-2021_01_06_425584 581 28 insulin insulin NN 10_1101-2021_01_06_425584 581 29 signaling signal VBG 10_1101-2021_01_06_425584 581 30 . . . 10_1101-2021_01_06_425584 582 1 Cell Cell NNP 10_1101-2021_01_06_425584 582 2 Cycle Cycle NNP 10_1101-2021_01_06_425584 582 3 2010 2010 CD 10_1101-2021_01_06_425584 582 4 , , , 10_1101-2021_01_06_425584 582 5 9 9 CD 10_1101-2021_01_06_425584 582 6 , , , 10_1101-2021_01_06_425584 582 7 ( ( -LRB- 10_1101-2021_01_06_425584 582 8 3 3 CD 10_1101-2021_01_06_425584 582 9 ) ) -RRB- 10_1101-2021_01_06_425584 582 10 , , , 10_1101-2021_01_06_425584 582 11 460 460 CD 10_1101-2021_01_06_425584 582 12 - - SYM 10_1101-2021_01_06_425584 582 13 6 6 CD 10_1101-2021_01_06_425584 582 14 . . . 10_1101-2021_01_06_425584 583 1 821 821 CD 10_1101-2021_01_06_425584 583 2 822 822 CD 10_1101-2021_01_06_425584 583 3 .CC .CC : 10_1101-2021_01_06_425584 583 4 - - HYPH 10_1101-2021_01_06_425584 583 5 BY by IN 10_1101-2021_01_06_425584 583 6 - - HYPH 10_1101-2021_01_06_425584 583 7 NC NC NNP 10_1101-2021_01_06_425584 583 8 - - HYPH 10_1101-2021_01_06_425584 583 9 ND ND NNP 10_1101-2021_01_06_425584 583 10 4.0 4.0 CD 10_1101-2021_01_06_425584 583 11 International International NNP 10_1101-2021_01_06_425584 583 12 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 583 13 under under IN 10_1101-2021_01_06_425584 583 14 a a DT 10_1101-2021_01_06_425584 583 15 ( ( -LRB- 10_1101-2021_01_06_425584 583 16 which which WDT 10_1101-2021_01_06_425584 583 17 was be VBD 10_1101-2021_01_06_425584 583 18 not not RB 10_1101-2021_01_06_425584 583 19 certified certify VBN 10_1101-2021_01_06_425584 583 20 by by IN 10_1101-2021_01_06_425584 583 21 peer peer NN 10_1101-2021_01_06_425584 583 22 review review NN 10_1101-2021_01_06_425584 583 23 ) ) -RRB- 10_1101-2021_01_06_425584 583 24 is be VBZ 10_1101-2021_01_06_425584 583 25 the the DT 10_1101-2021_01_06_425584 583 26 author author NN 10_1101-2021_01_06_425584 583 27 / / SYM 10_1101-2021_01_06_425584 583 28 funder funder NN 10_1101-2021_01_06_425584 583 29 , , , 10_1101-2021_01_06_425584 583 30 who who WP 10_1101-2021_01_06_425584 583 31 has have VBZ 10_1101-2021_01_06_425584 583 32 granted grant VBN 10_1101-2021_01_06_425584 583 33 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 583 34 a a DT 10_1101-2021_01_06_425584 583 35 license license NN 10_1101-2021_01_06_425584 583 36 to to TO 10_1101-2021_01_06_425584 583 37 display display VB 10_1101-2021_01_06_425584 583 38 the the DT 10_1101-2021_01_06_425584 583 39 preprint preprint NN 10_1101-2021_01_06_425584 583 40 in in IN 10_1101-2021_01_06_425584 583 41 perpetuity perpetuity NN 10_1101-2021_01_06_425584 583 42 . . . 10_1101-2021_01_06_425584 584 1 It -PRON- PRP 10_1101-2021_01_06_425584 584 2 is be VBZ 10_1101-2021_01_06_425584 584 3 made make VBN 10_1101-2021_01_06_425584 584 4 The the DT 10_1101-2021_01_06_425584 584 5 copyright copyright NN 10_1101-2021_01_06_425584 584 6 holder holder NN 10_1101-2021_01_06_425584 584 7 for for IN 10_1101-2021_01_06_425584 584 8 this this DT 10_1101-2021_01_06_425584 584 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 584 10 version version NN 10_1101-2021_01_06_425584 584 11 posted post VBD 10_1101-2021_01_06_425584 584 12 January January NNP 10_1101-2021_01_06_425584 584 13 8 8 CD 10_1101-2021_01_06_425584 584 14 , , , 10_1101-2021_01_06_425584 584 15 2021 2021 CD 10_1101-2021_01_06_425584 584 16 . . . 10_1101-2021_01_06_425584 584 17 ; ; : 10_1101-2021_01_06_425584 584 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 584 19 : : : 10_1101-2021_01_06_425584 584 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 584 21 preprint preprint NN 10_1101-2021_01_06_425584 584 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 584 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 584 24 27 27 CD 10_1101-2021_01_06_425584 584 25 Figure figure NN 10_1101-2021_01_06_425584 584 26 legends legend VBZ 10_1101-2021_01_06_425584 584 27 823 823 CD 10_1101-2021_01_06_425584 584 28 824 824 CD 10_1101-2021_01_06_425584 584 29 Figure figure NN 10_1101-2021_01_06_425584 584 30 1 1 CD 10_1101-2021_01_06_425584 584 31 . . . 10_1101-2021_01_06_425584 585 1 Illustration illustration NN 10_1101-2021_01_06_425584 585 2 of of IN 10_1101-2021_01_06_425584 585 3 the the DT 10_1101-2021_01_06_425584 585 4 methodology methodology NN 10_1101-2021_01_06_425584 585 5 followed follow VBN 10_1101-2021_01_06_425584 585 6 in in IN 10_1101-2021_01_06_425584 585 7 this this DT 10_1101-2021_01_06_425584 585 8 study study NN 10_1101-2021_01_06_425584 585 9 . . . 10_1101-2021_01_06_425584 586 1 825 825 CD 10_1101-2021_01_06_425584 586 2 826 826 CD 10_1101-2021_01_06_425584 586 3 Figure Figure NNP 10_1101-2021_01_06_425584 586 4 2 2 CD 10_1101-2021_01_06_425584 586 5 . . . 10_1101-2021_01_06_425584 587 1 Simulated simulate VBN 10_1101-2021_01_06_425584 587 2 diabetes diabete NNS 10_1101-2021_01_06_425584 587 3 induced induce VBD 10_1101-2021_01_06_425584 587 4 changes change NNS 10_1101-2021_01_06_425584 587 5 in in IN 10_1101-2021_01_06_425584 587 6 the the DT 10_1101-2021_01_06_425584 587 7 metabolome metabolome NN 10_1101-2021_01_06_425584 587 8 of of IN 10_1101-2021_01_06_425584 587 9 bovine bovine JJ 10_1101-2021_01_06_425584 587 10 coronary coronary JJ 10_1101-2021_01_06_425584 587 11 827 827 CD 10_1101-2021_01_06_425584 587 12 artery artery NN 10_1101-2021_01_06_425584 587 13 endothelial endothelial JJ 10_1101-2021_01_06_425584 587 14 cells cell NNS 10_1101-2021_01_06_425584 587 15 ( ( -LRB- 10_1101-2021_01_06_425584 587 16 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 587 17 ) ) -RRB- 10_1101-2021_01_06_425584 587 18 . . . 10_1101-2021_01_06_425584 588 1 ( ( -LRB- 10_1101-2021_01_06_425584 588 2 A a DT 10_1101-2021_01_06_425584 588 3 ) ) -RRB- 10_1101-2021_01_06_425584 588 4 Venn Venn NNP 10_1101-2021_01_06_425584 588 5 diagram diagram NN 10_1101-2021_01_06_425584 588 6 of of IN 10_1101-2021_01_06_425584 588 7 features feature NNS 10_1101-2021_01_06_425584 588 8 identified identify VBN 10_1101-2021_01_06_425584 588 9 among among IN 10_1101-2021_01_06_425584 588 10 MZmine MZmine NNP 10_1101-2021_01_06_425584 588 11 and and CC 10_1101-2021_01_06_425584 588 12 828 828 CD 10_1101-2021_01_06_425584 588 13 XCMS XCMS NNP 10_1101-2021_01_06_425584 588 14 software software NN 10_1101-2021_01_06_425584 588 15 ( ( -LRB- 10_1101-2021_01_06_425584 588 16 0.01 0.01 CD 10_1101-2021_01_06_425584 588 17 Da Da NNP 10_1101-2021_01_06_425584 588 18 and and CC 10_1101-2021_01_06_425584 588 19 1 1 CD 10_1101-2021_01_06_425584 588 20 min min NNP 10_1101-2021_01_06_425584 588 21 retention retention NN 10_1101-2021_01_06_425584 588 22 time time NN 10_1101-2021_01_06_425584 588 23 , , , 10_1101-2021_01_06_425584 588 24 thresholds threshold NNS 10_1101-2021_01_06_425584 588 25 ) ) -RRB- 10_1101-2021_01_06_425584 588 26 on on IN 10_1101-2021_01_06_425584 588 27 LC LC NNP 10_1101-2021_01_06_425584 588 28 - - HYPH 10_1101-2021_01_06_425584 588 29 MS2 MS2 NNP 10_1101-2021_01_06_425584 588 30 datasets dataset NNS 10_1101-2021_01_06_425584 588 31 . . . 10_1101-2021_01_06_425584 589 1 ( ( -LRB- 10_1101-2021_01_06_425584 589 2 B b NN 10_1101-2021_01_06_425584 589 3 ) ) -RRB- 10_1101-2021_01_06_425584 589 4 Volcano volcano NN 10_1101-2021_01_06_425584 589 5 829 829 CD 10_1101-2021_01_06_425584 589 6 plot plot NN 10_1101-2021_01_06_425584 589 7 of of IN 10_1101-2021_01_06_425584 589 8 all all DT 10_1101-2021_01_06_425584 589 9 quantified quantify VBN 10_1101-2021_01_06_425584 589 10 metabolites metabolite NNS 10_1101-2021_01_06_425584 589 11 displaying display VBG 10_1101-2021_01_06_425584 589 12 differences difference NNS 10_1101-2021_01_06_425584 589 13 in in IN 10_1101-2021_01_06_425584 589 14 relative relative JJ 10_1101-2021_01_06_425584 589 15 abundance abundance NN 10_1101-2021_01_06_425584 589 16 ( ( -LRB- 10_1101-2021_01_06_425584 589 17 > > XX 10_1101-2021_01_06_425584 589 18 + + SYM 10_1101-2021_01_06_425584 589 19 /-30 /-30 CD 10_1101-2021_01_06_425584 589 20 % % NN 10_1101-2021_01_06_425584 589 21 change change NN 10_1101-2021_01_06_425584 589 22 , , , 10_1101-2021_01_06_425584 589 23 830 830 CD 10_1101-2021_01_06_425584 589 24 < < XX 10_1101-2021_01_06_425584 589 25 0.05 0.05 CD 10_1101-2021_01_06_425584 589 26 p p NN 10_1101-2021_01_06_425584 589 27 - - HYPH 10_1101-2021_01_06_425584 589 28 value value NN 10_1101-2021_01_06_425584 589 29 cut cut NN 10_1101-2021_01_06_425584 589 30 - - HYPH 10_1101-2021_01_06_425584 589 31 offs off NNS 10_1101-2021_01_06_425584 589 32 ) ) -RRB- 10_1101-2021_01_06_425584 589 33 between between IN 10_1101-2021_01_06_425584 589 34 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 589 35 cultured cultured JJ 10_1101-2021_01_06_425584 589 36 in in IN 10_1101-2021_01_06_425584 589 37 control control NN 10_1101-2021_01_06_425584 589 38 ( ( -LRB- 10_1101-2021_01_06_425584 589 39 NG NG NNP 10_1101-2021_01_06_425584 589 40 ) ) -RRB- 10_1101-2021_01_06_425584 589 41 media medium NNS 10_1101-2021_01_06_425584 589 42 and and CC 10_1101-2021_01_06_425584 589 43 simulated simulate VBN 10_1101-2021_01_06_425584 589 44 diabetes diabetes NN 10_1101-2021_01_06_425584 589 45 831 831 CD 10_1101-2021_01_06_425584 589 46 ( ( -LRB- 10_1101-2021_01_06_425584 589 47 HG+ HG+ NNP 10_1101-2021_01_06_425584 589 48 HI HI NNP 10_1101-2021_01_06_425584 589 49 ) ) -RRB- 10_1101-2021_01_06_425584 589 50 for for IN 10_1101-2021_01_06_425584 589 51 twelve twelve CD 10_1101-2021_01_06_425584 589 52 days day NNS 10_1101-2021_01_06_425584 589 53 . . . 10_1101-2021_01_06_425584 590 1 Values value NNS 10_1101-2021_01_06_425584 590 2 ( ( -LRB- 10_1101-2021_01_06_425584 590 3 dots dot NNS 10_1101-2021_01_06_425584 590 4 ) ) -RRB- 10_1101-2021_01_06_425584 590 5 represent represent VBP 10_1101-2021_01_06_425584 590 6 the the DT 10_1101-2021_01_06_425584 590 7 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 590 8 / / SYM 10_1101-2021_01_06_425584 590 9 NG NG NNP 10_1101-2021_01_06_425584 590 10 ratio ratio NN 10_1101-2021_01_06_425584 590 11 for for IN 10_1101-2021_01_06_425584 590 12 all all DT 10_1101-2021_01_06_425584 590 13 metabolites metabolite NNS 10_1101-2021_01_06_425584 590 14 . . . 10_1101-2021_01_06_425584 591 1 Red Red NNP 10_1101-2021_01_06_425584 591 2 832 832 CD 10_1101-2021_01_06_425584 591 3 and and CC 10_1101-2021_01_06_425584 591 4 blue blue JJ 10_1101-2021_01_06_425584 591 5 dots dot NNS 10_1101-2021_01_06_425584 591 6 denote denote VBP 10_1101-2021_01_06_425584 591 7 downregulated downregulated JJ 10_1101-2021_01_06_425584 591 8 and and CC 10_1101-2021_01_06_425584 591 9 upregulated upregulated JJ 10_1101-2021_01_06_425584 591 10 metabolites metabolite NNS 10_1101-2021_01_06_425584 591 11 in in IN 10_1101-2021_01_06_425584 591 12 the the DT 10_1101-2021_01_06_425584 591 13 HG HG NNP 10_1101-2021_01_06_425584 591 14 + + CC 10_1101-2021_01_06_425584 591 15 HI HI NNP 10_1101-2021_01_06_425584 591 16 group group NN 10_1101-2021_01_06_425584 591 17 vs. vs. IN 10_1101-2021_01_06_425584 591 18 NG NG NNP 10_1101-2021_01_06_425584 591 19 833 833 CD 10_1101-2021_01_06_425584 591 20 group group NN 10_1101-2021_01_06_425584 591 21 , , , 10_1101-2021_01_06_425584 591 22 respectively respectively RB 10_1101-2021_01_06_425584 591 23 . . . 10_1101-2021_01_06_425584 592 1 ( ( -LRB- 10_1101-2021_01_06_425584 592 2 C C NNP 10_1101-2021_01_06_425584 592 3 ) ) -RRB- 10_1101-2021_01_06_425584 592 4 Principal Principal NNP 10_1101-2021_01_06_425584 592 5 Component Component NNP 10_1101-2021_01_06_425584 592 6 Analysis Analysis NNP 10_1101-2021_01_06_425584 592 7 ( ( -LRB- 10_1101-2021_01_06_425584 592 8 PCA PCA NNP 10_1101-2021_01_06_425584 592 9 ) ) -RRB- 10_1101-2021_01_06_425584 592 10 of of IN 10_1101-2021_01_06_425584 592 11 LC LC NNP 10_1101-2021_01_06_425584 592 12 - - HYPH 10_1101-2021_01_06_425584 592 13 MS2 MS2 NNP 10_1101-2021_01_06_425584 592 14 datasets dataset NNS 10_1101-2021_01_06_425584 592 15 . . . 10_1101-2021_01_06_425584 593 1 Data datum NNS 10_1101-2021_01_06_425584 593 2 was be VBD 10_1101-2021_01_06_425584 593 3 log log NN 10_1101-2021_01_06_425584 593 4 834 834 CD 10_1101-2021_01_06_425584 593 5 transformed transform VBD 10_1101-2021_01_06_425584 593 6 without without IN 10_1101-2021_01_06_425584 593 7 scaling scale VBG 10_1101-2021_01_06_425584 593 8 . . . 10_1101-2021_01_06_425584 594 1 Shade shade NN 10_1101-2021_01_06_425584 594 2 areas area NNS 10_1101-2021_01_06_425584 594 3 depict depict VBP 10_1101-2021_01_06_425584 594 4 the the DT 10_1101-2021_01_06_425584 594 5 95 95 CD 10_1101-2021_01_06_425584 594 6 % % NN 10_1101-2021_01_06_425584 594 7 confidence confidence NN 10_1101-2021_01_06_425584 594 8 intervals interval NNS 10_1101-2021_01_06_425584 594 9 . . . 10_1101-2021_01_06_425584 595 1 ( ( -LRB- 10_1101-2021_01_06_425584 595 2 C C NNP 10_1101-2021_01_06_425584 595 3 ) ) -RRB- 10_1101-2021_01_06_425584 595 4 HeatMap HeatMap NNP 10_1101-2021_01_06_425584 595 5 of of IN 10_1101-2021_01_06_425584 595 6 835 835 CD 10_1101-2021_01_06_425584 595 7 the the DT 10_1101-2021_01_06_425584 595 8 top top JJ 10_1101-2021_01_06_425584 595 9 100 100 CD 10_1101-2021_01_06_425584 595 10 metabolites metabolite NNS 10_1101-2021_01_06_425584 595 11 ranked rank VBN 10_1101-2021_01_06_425584 595 12 by by IN 10_1101-2021_01_06_425584 595 13 t t NN 10_1101-2021_01_06_425584 595 14 - - HYPH 10_1101-2021_01_06_425584 595 15 test test NN 10_1101-2021_01_06_425584 595 16 . . . 10_1101-2021_01_06_425584 596 1 Abbreviations abbreviation NNS 10_1101-2021_01_06_425584 596 2 : : : 10_1101-2021_01_06_425584 596 3 NG NG NNP 10_1101-2021_01_06_425584 596 4 , , , 10_1101-2021_01_06_425584 596 5 normal normal JJ 10_1101-2021_01_06_425584 596 6 glucose glucose NN 10_1101-2021_01_06_425584 596 7 ; ; : 10_1101-2021_01_06_425584 596 8 HG HG NNP 10_1101-2021_01_06_425584 596 9 , , , 10_1101-2021_01_06_425584 596 10 high high JJ 10_1101-2021_01_06_425584 596 11 glucose glucose NN 10_1101-2021_01_06_425584 596 12 ; ; : 10_1101-2021_01_06_425584 596 13 836 836 CD 10_1101-2021_01_06_425584 596 14 HI HI NNP 10_1101-2021_01_06_425584 596 15 , , , 10_1101-2021_01_06_425584 596 16 high high JJ 10_1101-2021_01_06_425584 596 17 insulin insulin NN 10_1101-2021_01_06_425584 596 18 ; ; : 10_1101-2021_01_06_425584 596 19 QC QC NNP 10_1101-2021_01_06_425584 596 20 , , , 10_1101-2021_01_06_425584 596 21 quality quality NN 10_1101-2021_01_06_425584 596 22 control control NN 10_1101-2021_01_06_425584 596 23 . . . 10_1101-2021_01_06_425584 597 1 837 837 CD 10_1101-2021_01_06_425584 597 2 838 838 CD 10_1101-2021_01_06_425584 597 3 Figure figure NN 10_1101-2021_01_06_425584 597 4 3 3 CD 10_1101-2021_01_06_425584 597 5 . . . 10_1101-2021_01_06_425584 598 1 Bovine bovine JJ 10_1101-2021_01_06_425584 598 2 coronary coronary JJ 10_1101-2021_01_06_425584 598 3 artery artery NN 10_1101-2021_01_06_425584 598 4 endothelial endothelial JJ 10_1101-2021_01_06_425584 598 5 cells cell NNS 10_1101-2021_01_06_425584 598 6 ( ( -LRB- 10_1101-2021_01_06_425584 598 7 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 598 8 ) ) -RRB- 10_1101-2021_01_06_425584 598 9 metabolite metabolite JJ 10_1101-2021_01_06_425584 598 10 molecular molecular JJ 10_1101-2021_01_06_425584 598 11 network network NN 10_1101-2021_01_06_425584 598 12 . . . 10_1101-2021_01_06_425584 599 1 839 839 CD 10_1101-2021_01_06_425584 599 2 ( ( -LRB- 10_1101-2021_01_06_425584 599 3 A a NN 10_1101-2021_01_06_425584 599 4 ) ) -RRB- 10_1101-2021_01_06_425584 599 5 Molecular molecular JJ 10_1101-2021_01_06_425584 599 6 classes class NNS 10_1101-2021_01_06_425584 599 7 ( ( -LRB- 10_1101-2021_01_06_425584 599 8 according accord VBG 10_1101-2021_01_06_425584 599 9 to to IN 10_1101-2021_01_06_425584 599 10 Classyfire Classyfire NNP 10_1101-2021_01_06_425584 599 11 ) ) -RRB- 10_1101-2021_01_06_425584 599 12 of of IN 10_1101-2021_01_06_425584 599 13 the the DT 10_1101-2021_01_06_425584 599 14 metabolome metabolome NN 10_1101-2021_01_06_425584 599 15 identified identify VBN 10_1101-2021_01_06_425584 599 16 by by IN 10_1101-2021_01_06_425584 599 17 the the DT 10_1101-2021_01_06_425584 599 18 840 840 CD 10_1101-2021_01_06_425584 599 19 MolNetEnhancer MolNetEnhancer NNP 10_1101-2021_01_06_425584 599 20 workflow workflow NN 10_1101-2021_01_06_425584 599 21 and and CC 10_1101-2021_01_06_425584 599 22 visualized visualize VBN 10_1101-2021_01_06_425584 599 23 by by IN 10_1101-2021_01_06_425584 599 24 Cytoscape Cytoscape NNP 10_1101-2021_01_06_425584 599 25 version version NN 10_1101-2021_01_06_425584 599 26 3.8.2 3.8.2 CD 10_1101-2021_01_06_425584 599 27 . . . 10_1101-2021_01_06_425584 600 1 Each each DT 10_1101-2021_01_06_425584 600 2 node node NN 10_1101-2021_01_06_425584 600 3 represents represent VBZ 10_1101-2021_01_06_425584 600 4 a a DT 10_1101-2021_01_06_425584 600 5 841 841 CD 10_1101-2021_01_06_425584 600 6 unique unique JJ 10_1101-2021_01_06_425584 600 7 feature feature NN 10_1101-2021_01_06_425584 600 8 and and CC 10_1101-2021_01_06_425584 600 9 the the DT 10_1101-2021_01_06_425584 600 10 color color NN 10_1101-2021_01_06_425584 600 11 of of IN 10_1101-2021_01_06_425584 600 12 the the DT 10_1101-2021_01_06_425584 600 13 node node NN 10_1101-2021_01_06_425584 600 14 denotes denote VBZ 10_1101-2021_01_06_425584 600 15 the the DT 10_1101-2021_01_06_425584 600 16 associated associated NNP 10_1101-2021_01_06_425584 600 17 chemical chemical NNP 10_1101-2021_01_06_425584 600 18 class class NNP 10_1101-2021_01_06_425584 600 19 . . . 10_1101-2021_01_06_425584 601 1 The the DT 10_1101-2021_01_06_425584 601 2 thickness thickness NN 10_1101-2021_01_06_425584 601 3 of of IN 10_1101-2021_01_06_425584 601 4 842 842 CD 10_1101-2021_01_06_425584 601 5 the the DT 10_1101-2021_01_06_425584 601 6 edge edge NN 10_1101-2021_01_06_425584 601 7 ( ( -LRB- 10_1101-2021_01_06_425584 601 8 connectivity connectivity NN 10_1101-2021_01_06_425584 601 9 ) ) -RRB- 10_1101-2021_01_06_425584 601 10 indicates indicate VBZ 10_1101-2021_01_06_425584 601 11 the the DT 10_1101-2021_01_06_425584 601 12 MS2 MS2 NNP 10_1101-2021_01_06_425584 601 13 similarity similarity NN 10_1101-2021_01_06_425584 601 14 ( ( -LRB- 10_1101-2021_01_06_425584 601 15 Cosine Cosine NNP 10_1101-2021_01_06_425584 601 16 score score NN 10_1101-2021_01_06_425584 601 17 ) ) -RRB- 10_1101-2021_01_06_425584 601 18 among among IN 10_1101-2021_01_06_425584 601 19 features feature NNS 10_1101-2021_01_06_425584 601 20 . . . 10_1101-2021_01_06_425584 602 1 The the DT 10_1101-2021_01_06_425584 602 2 m m NNP 10_1101-2021_01_06_425584 602 3 / / SYM 10_1101-2021_01_06_425584 602 4 z z NNP 10_1101-2021_01_06_425584 602 5 value value NN 10_1101-2021_01_06_425584 602 6 843 843 CD 10_1101-2021_01_06_425584 602 7 of of IN 10_1101-2021_01_06_425584 602 8 the the DT 10_1101-2021_01_06_425584 602 9 feature feature NN 10_1101-2021_01_06_425584 602 10 is be VBZ 10_1101-2021_01_06_425584 602 11 shown show VBN 10_1101-2021_01_06_425584 602 12 inside inside IN 10_1101-2021_01_06_425584 602 13 the the DT 10_1101-2021_01_06_425584 602 14 node node NN 10_1101-2021_01_06_425584 602 15 and and CC 10_1101-2021_01_06_425584 602 16 is be VBZ 10_1101-2021_01_06_425584 602 17 proportional proportional JJ 10_1101-2021_01_06_425584 602 18 to to IN 10_1101-2021_01_06_425584 602 19 the the DT 10_1101-2021_01_06_425584 602 20 size size NN 10_1101-2021_01_06_425584 602 21 of of IN 10_1101-2021_01_06_425584 602 22 the the DT 10_1101-2021_01_06_425584 602 23 node node NN 10_1101-2021_01_06_425584 602 24 . . . 10_1101-2021_01_06_425584 603 1 Three three CD 10_1101-2021_01_06_425584 603 2 selected select VBD 10_1101-2021_01_06_425584 603 3 844 844 CD 10_1101-2021_01_06_425584 603 4 clusters cluster NNS 10_1101-2021_01_06_425584 603 5 or or CC 10_1101-2021_01_06_425584 603 6 connected connect VBN 10_1101-2021_01_06_425584 603 7 features feature NNS 10_1101-2021_01_06_425584 603 8 as as IN 10_1101-2021_01_06_425584 603 9 relevant relevant JJ 10_1101-2021_01_06_425584 603 10 are be VBP 10_1101-2021_01_06_425584 603 11 shown show VBN 10_1101-2021_01_06_425584 603 12 . . . 10_1101-2021_01_06_425584 604 1 ( ( -LRB- 10_1101-2021_01_06_425584 604 2 B b NN 10_1101-2021_01_06_425584 604 3 ) ) -RRB- 10_1101-2021_01_06_425584 604 4 Inset Inset NNP 10_1101-2021_01_06_425584 604 5 of of IN 10_1101-2021_01_06_425584 604 6 cluster cluster NN 10_1101-2021_01_06_425584 604 7 1 1 CD 10_1101-2021_01_06_425584 604 8 denoting denote VBG 10_1101-2021_01_06_425584 604 9 the the DT 10_1101-2021_01_06_425584 604 10 presence presence NN 10_1101-2021_01_06_425584 604 11 845 845 CD 10_1101-2021_01_06_425584 604 12 of of IN 10_1101-2021_01_06_425584 604 13 phosphocholine phosphocholine NN 10_1101-2021_01_06_425584 604 14 ( ( -LRB- 10_1101-2021_01_06_425584 604 15 PC)-containing pc)-containe VBG 10_1101-2021_01_06_425584 604 16 lipids lipid NNS 10_1101-2021_01_06_425584 604 17 . . . 10_1101-2021_01_06_425584 605 1 Significant significant JJ 10_1101-2021_01_06_425584 605 2 differential differential NN 10_1101-2021_01_06_425584 605 3 abundant abundant JJ 10_1101-2021_01_06_425584 605 4 features feature NNS 10_1101-2021_01_06_425584 605 5 among among IN 10_1101-2021_01_06_425584 605 6 846 846 CD 10_1101-2021_01_06_425584 605 7 simulated simulate VBN 10_1101-2021_01_06_425584 605 8 diabetes diabete NNS 10_1101-2021_01_06_425584 605 9 ( ( -LRB- 10_1101-2021_01_06_425584 605 10 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 605 11 ) ) -RRB- 10_1101-2021_01_06_425584 605 12 and and CC 10_1101-2021_01_06_425584 605 13 control control NN 10_1101-2021_01_06_425584 605 14 ( ( -LRB- 10_1101-2021_01_06_425584 605 15 NG NG NNP 10_1101-2021_01_06_425584 605 16 ) ) -RRB- 10_1101-2021_01_06_425584 605 17 groups group NNS 10_1101-2021_01_06_425584 605 18 are be VBP 10_1101-2021_01_06_425584 605 19 indicated indicate VBN 10_1101-2021_01_06_425584 605 20 with with IN 10_1101-2021_01_06_425584 605 21 an an DT 10_1101-2021_01_06_425584 605 22 asterisk asterisk NN 10_1101-2021_01_06_425584 605 23 ( ( -LRB- 10_1101-2021_01_06_425584 605 24 p p NN 10_1101-2021_01_06_425584 605 25 - - HYPH 10_1101-2021_01_06_425584 605 26 value value NN 10_1101-2021_01_06_425584 605 27 847 847 CD 10_1101-2021_01_06_425584 605 28 < < XX 10_1101-2021_01_06_425584 605 29 0.05 0.05 CD 10_1101-2021_01_06_425584 605 30 ) ) -RRB- 10_1101-2021_01_06_425584 605 31 . . . 10_1101-2021_01_06_425584 606 1 ( ( -LRB- 10_1101-2021_01_06_425584 606 2 C C NNP 10_1101-2021_01_06_425584 606 3 ) ) -RRB- 10_1101-2021_01_06_425584 606 4 Characterization characterization NN 10_1101-2021_01_06_425584 606 5 of of IN 10_1101-2021_01_06_425584 606 6 features feature NNS 10_1101-2021_01_06_425584 606 7 in in IN 10_1101-2021_01_06_425584 606 8 ( ( -LRB- 10_1101-2021_01_06_425584 606 9 B b NN 10_1101-2021_01_06_425584 606 10 ) ) -RRB- 10_1101-2021_01_06_425584 606 11 aided aid VBN 10_1101-2021_01_06_425584 606 12 by by IN 10_1101-2021_01_06_425584 606 13 substructure substructure NN 10_1101-2021_01_06_425584 606 14 recognition recognition NN 10_1101-2021_01_06_425584 606 15 by by IN 10_1101-2021_01_06_425584 606 16 MSLDA MSLDA NNP 10_1101-2021_01_06_425584 606 17 848 848 CD 10_1101-2021_01_06_425584 606 18 software software NN 10_1101-2021_01_06_425584 606 19 using use VBG 10_1101-2021_01_06_425584 606 20 MS1 MS1 NNP 10_1101-2021_01_06_425584 606 21 visualization visualization NN 10_1101-2021_01_06_425584 606 22 in in IN 10_1101-2021_01_06_425584 606 23 www.ms2lda.org www.ms2lda.org NN 10_1101-2021_01_06_425584 606 24 . . . 10_1101-2021_01_06_425584 607 1 Fragment fragment NN 10_1101-2021_01_06_425584 607 2 at at IN 10_1101-2021_01_06_425584 607 3 m m NN 10_1101-2021_01_06_425584 607 4 / / SYM 10_1101-2021_01_06_425584 607 5 z z NNP 10_1101-2021_01_06_425584 607 6 184.0725 184.0725 NN 10_1101-2021_01_06_425584 607 7 linked link VBN 10_1101-2021_01_06_425584 607 8 to to IN 10_1101-2021_01_06_425584 607 9 a a DT 10_1101-2021_01_06_425584 607 10 PC pc NN 10_1101-2021_01_06_425584 607 11 849 849 CD 10_1101-2021_01_06_425584 607 12 head head NN 10_1101-2021_01_06_425584 607 13 group group NN 10_1101-2021_01_06_425584 607 14 by by IN 10_1101-2021_01_06_425584 607 15 mzCloud mzCloud NNP 10_1101-2021_01_06_425584 607 16 in in IN 10_1101-2021_01_06_425584 607 17 silico silico NNP 10_1101-2021_01_06_425584 607 18 prediction prediction NN 10_1101-2021_01_06_425584 607 19 ( ( -LRB- 10_1101-2021_01_06_425584 607 20 www.mzCloud.org www.mzcloud.org UH 10_1101-2021_01_06_425584 607 21 ) ) -RRB- 10_1101-2021_01_06_425584 607 22 . . . 10_1101-2021_01_06_425584 608 1 Abbreviations abbreviation NNS 10_1101-2021_01_06_425584 608 2 : : : 10_1101-2021_01_06_425584 608 3 M2 M2 NNP 10_1101-2021_01_06_425584 608 4 M M NNP 10_1101-2021_01_06_425584 608 5 , , , 10_1101-2021_01_06_425584 608 6 mass2motif mass2motif NNP 10_1101-2021_01_06_425584 608 7 ; ; : 10_1101-2021_01_06_425584 608 8 850 850 CD 10_1101-2021_01_06_425584 608 9 FC FC NNP 10_1101-2021_01_06_425584 608 10 , , , 10_1101-2021_01_06_425584 608 11 fold fold VB 10_1101-2021_01_06_425584 608 12 change change NN 10_1101-2021_01_06_425584 608 13 ; ; : 10_1101-2021_01_06_425584 608 14 NG NG NNP 10_1101-2021_01_06_425584 608 15 , , , 10_1101-2021_01_06_425584 608 16 normal normal JJ 10_1101-2021_01_06_425584 608 17 glucose glucose NN 10_1101-2021_01_06_425584 608 18 ; ; : 10_1101-2021_01_06_425584 608 19 HG HG NNP 10_1101-2021_01_06_425584 608 20 , , , 10_1101-2021_01_06_425584 608 21 high high JJ 10_1101-2021_01_06_425584 608 22 glucose glucose NN 10_1101-2021_01_06_425584 608 23 ; ; : 10_1101-2021_01_06_425584 608 24 HI hi UH 10_1101-2021_01_06_425584 608 25 , , , 10_1101-2021_01_06_425584 608 26 high high JJ 10_1101-2021_01_06_425584 608 27 insulin insulin NN 10_1101-2021_01_06_425584 608 28 . . . 10_1101-2021_01_06_425584 609 1 Chemical chemical JJ 10_1101-2021_01_06_425584 609 2 structures structure NNS 10_1101-2021_01_06_425584 609 3 851 851 CD 10_1101-2021_01_06_425584 609 4 were be VBD 10_1101-2021_01_06_425584 609 5 drawn draw VBN 10_1101-2021_01_06_425584 609 6 by by IN 10_1101-2021_01_06_425584 609 7 ChemDraw ChemDraw NNP 10_1101-2021_01_06_425584 609 8 Professional Professional NNP 10_1101-2021_01_06_425584 609 9 version version NN 10_1101-2021_01_06_425584 609 10 16.0.1.4 16.0.1.4 NN 10_1101-2021_01_06_425584 609 11 . . . 10_1101-2021_01_06_425584 610 1 852 852 CD 10_1101-2021_01_06_425584 610 2 853 853 CD 10_1101-2021_01_06_425584 610 3 Figure figure NN 10_1101-2021_01_06_425584 610 4 4 4 CD 10_1101-2021_01_06_425584 610 5 . . . 10_1101-2021_01_06_425584 611 1 Peptide peptide JJ 10_1101-2021_01_06_425584 611 2 metabolites metabolite NNS 10_1101-2021_01_06_425584 611 3 modulated modulate VBN 10_1101-2021_01_06_425584 611 4 by by IN 10_1101-2021_01_06_425584 611 5 simulated simulated JJ 10_1101-2021_01_06_425584 611 6 diabetes diabete NNS 10_1101-2021_01_06_425584 611 7 in in IN 10_1101-2021_01_06_425584 611 8 bovine bovine JJ 10_1101-2021_01_06_425584 611 9 coronary coronary JJ 10_1101-2021_01_06_425584 611 10 artery artery NN 10_1101-2021_01_06_425584 611 11 854 854 CD 10_1101-2021_01_06_425584 611 12 endothelial endothelial JJ 10_1101-2021_01_06_425584 611 13 cells cell NNS 10_1101-2021_01_06_425584 611 14 ( ( -LRB- 10_1101-2021_01_06_425584 611 15 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 611 16 ) ) -RRB- 10_1101-2021_01_06_425584 611 17 . . . 10_1101-2021_01_06_425584 612 1 ( ( -LRB- 10_1101-2021_01_06_425584 612 2 A a DT 10_1101-2021_01_06_425584 612 3 ) ) -RRB- 10_1101-2021_01_06_425584 612 4 Cluster cluster NN 10_1101-2021_01_06_425584 612 5 2 2 CD 10_1101-2021_01_06_425584 612 6 retrieved retrieve VBN 10_1101-2021_01_06_425584 612 7 from from IN 10_1101-2021_01_06_425584 612 8 the the DT 10_1101-2021_01_06_425584 612 9 main main JJ 10_1101-2021_01_06_425584 612 10 molecular molecular JJ 10_1101-2021_01_06_425584 612 11 network network NN 10_1101-2021_01_06_425584 612 12 linked link VBN 10_1101-2021_01_06_425584 612 13 to to IN 10_1101-2021_01_06_425584 612 14 855 855 CD 10_1101-2021_01_06_425584 612 15 glutathione glutathione NN 10_1101-2021_01_06_425584 612 16 and and CC 10_1101-2021_01_06_425584 612 17 derivatives derivative NNS 10_1101-2021_01_06_425584 612 18 . . . 10_1101-2021_01_06_425584 613 1 The the DT 10_1101-2021_01_06_425584 613 2 fragments fragment NNS 10_1101-2021_01_06_425584 613 3 of of IN 10_1101-2021_01_06_425584 613 4 mass-2-motif mass-2-motif NNP 10_1101-2021_01_06_425584 613 5 ( ( -LRB- 10_1101-2021_01_06_425584 613 6 M2M)_453 m2m)_453 RB 10_1101-2021_01_06_425584 613 7 colored color VBN 10_1101-2021_01_06_425584 613 8 in in IN 10_1101-2021_01_06_425584 613 9 red red NNP 10_1101-2021_01_06_425584 613 10 are be VBP 10_1101-2021_01_06_425584 613 11 856 856 CD 10_1101-2021_01_06_425584 613 12 .CC .CC : 10_1101-2021_01_06_425584 613 13 - - HYPH 10_1101-2021_01_06_425584 613 14 BY by IN 10_1101-2021_01_06_425584 613 15 - - HYPH 10_1101-2021_01_06_425584 613 16 NC NC NNP 10_1101-2021_01_06_425584 613 17 - - HYPH 10_1101-2021_01_06_425584 613 18 ND ND NNP 10_1101-2021_01_06_425584 613 19 4.0 4.0 CD 10_1101-2021_01_06_425584 613 20 International International NNP 10_1101-2021_01_06_425584 613 21 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 613 22 under under IN 10_1101-2021_01_06_425584 613 23 a a DT 10_1101-2021_01_06_425584 613 24 ( ( -LRB- 10_1101-2021_01_06_425584 613 25 which which WDT 10_1101-2021_01_06_425584 613 26 was be VBD 10_1101-2021_01_06_425584 613 27 not not RB 10_1101-2021_01_06_425584 613 28 certified certify VBN 10_1101-2021_01_06_425584 613 29 by by IN 10_1101-2021_01_06_425584 613 30 peer peer NN 10_1101-2021_01_06_425584 613 31 review review NN 10_1101-2021_01_06_425584 613 32 ) ) -RRB- 10_1101-2021_01_06_425584 613 33 is be VBZ 10_1101-2021_01_06_425584 613 34 the the DT 10_1101-2021_01_06_425584 613 35 author author NN 10_1101-2021_01_06_425584 613 36 / / SYM 10_1101-2021_01_06_425584 613 37 funder funder NN 10_1101-2021_01_06_425584 613 38 , , , 10_1101-2021_01_06_425584 613 39 who who WP 10_1101-2021_01_06_425584 613 40 has have VBZ 10_1101-2021_01_06_425584 613 41 granted grant VBN 10_1101-2021_01_06_425584 613 42 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 613 43 a a DT 10_1101-2021_01_06_425584 613 44 license license NN 10_1101-2021_01_06_425584 613 45 to to TO 10_1101-2021_01_06_425584 613 46 display display VB 10_1101-2021_01_06_425584 613 47 the the DT 10_1101-2021_01_06_425584 613 48 preprint preprint NN 10_1101-2021_01_06_425584 613 49 in in IN 10_1101-2021_01_06_425584 613 50 perpetuity perpetuity NN 10_1101-2021_01_06_425584 613 51 . . . 10_1101-2021_01_06_425584 614 1 It -PRON- PRP 10_1101-2021_01_06_425584 614 2 is be VBZ 10_1101-2021_01_06_425584 614 3 made make VBN 10_1101-2021_01_06_425584 614 4 The the DT 10_1101-2021_01_06_425584 614 5 copyright copyright NN 10_1101-2021_01_06_425584 614 6 holder holder NN 10_1101-2021_01_06_425584 614 7 for for IN 10_1101-2021_01_06_425584 614 8 this this DT 10_1101-2021_01_06_425584 614 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 614 10 version version NN 10_1101-2021_01_06_425584 614 11 posted post VBD 10_1101-2021_01_06_425584 614 12 January January NNP 10_1101-2021_01_06_425584 614 13 8 8 CD 10_1101-2021_01_06_425584 614 14 , , , 10_1101-2021_01_06_425584 614 15 2021 2021 CD 10_1101-2021_01_06_425584 614 16 . . . 10_1101-2021_01_06_425584 614 17 ; ; : 10_1101-2021_01_06_425584 614 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 614 19 : : : 10_1101-2021_01_06_425584 614 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 614 21 preprint preprint NN 10_1101-2021_01_06_425584 614 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 614 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_06_425584 614 24 28 28 CD 10_1101-2021_01_06_425584 614 25 characteristic characteristic NN 10_1101-2021_01_06_425584 614 26 of of IN 10_1101-2021_01_06_425584 614 27 a a DT 10_1101-2021_01_06_425584 614 28 glutathione glutathione JJ 10_1101-2021_01_06_425584 614 29 core core NN 10_1101-2021_01_06_425584 614 30 and and CC 10_1101-2021_01_06_425584 614 31 the the DT 10_1101-2021_01_06_425584 614 32 fragments fragment NNS 10_1101-2021_01_06_425584 614 33 are be VBP 10_1101-2021_01_06_425584 614 34 shown show VBN 10_1101-2021_01_06_425584 614 35 in in IN 10_1101-2021_01_06_425584 614 36 red red NN 10_1101-2021_01_06_425584 614 37 . . . 10_1101-2021_01_06_425584 615 1 ( ( -LRB- 10_1101-2021_01_06_425584 615 2 B b NN 10_1101-2021_01_06_425584 615 3 ) ) -RRB- 10_1101-2021_01_06_425584 615 4 Features feature NNS 10_1101-2021_01_06_425584 615 5 associated associate VBD 10_1101-2021_01_06_425584 615 6 857 857 CD 10_1101-2021_01_06_425584 615 7 with with IN 10_1101-2021_01_06_425584 615 8 M2M_453 M2M_453 NNP 10_1101-2021_01_06_425584 615 9 using use VBG 10_1101-2021_01_06_425584 615 10 MS1 MS1 NNP 10_1101-2021_01_06_425584 615 11 visualization visualization NN 10_1101-2021_01_06_425584 615 12 in in IN 10_1101-2021_01_06_425584 615 13 www.ms2lda.org www.ms2lda.org NN 10_1101-2021_01_06_425584 615 14 . . . 10_1101-2021_01_06_425584 616 1 ( ( -LRB- 10_1101-2021_01_06_425584 616 2 C C NNP 10_1101-2021_01_06_425584 616 3 ) ) -RRB- 10_1101-2021_01_06_425584 616 4 Cluster Cluster NNP 10_1101-2021_01_06_425584 616 5 3 3 CD 10_1101-2021_01_06_425584 616 6 retrieved retrieve VBD 10_1101-2021_01_06_425584 616 7 from from IN 10_1101-2021_01_06_425584 616 8 the the DT 10_1101-2021_01_06_425584 616 9 main main JJ 10_1101-2021_01_06_425584 616 10 858 858 CD 10_1101-2021_01_06_425584 616 11 molecular molecular JJ 10_1101-2021_01_06_425584 616 12 network network NN 10_1101-2021_01_06_425584 616 13 linked link VBN 10_1101-2021_01_06_425584 616 14 to to IN 10_1101-2021_01_06_425584 616 15 phenylalanine phenylalanine NN 10_1101-2021_01_06_425584 616 16 - - HYPH 10_1101-2021_01_06_425584 616 17 based base VBN 10_1101-2021_01_06_425584 616 18 metabolites metabolite NNS 10_1101-2021_01_06_425584 616 19 . . . 10_1101-2021_01_06_425584 617 1 A a DT 10_1101-2021_01_06_425584 617 2 singular singular JJ 10_1101-2021_01_06_425584 617 3 node node NN 10_1101-2021_01_06_425584 617 4 at at IN 10_1101-2021_01_06_425584 617 5 m m NNP 10_1101-2021_01_06_425584 617 6 / / SYM 10_1101-2021_01_06_425584 617 7 z z NNP 10_1101-2021_01_06_425584 617 8 487.1548 487.1548 CD 10_1101-2021_01_06_425584 617 9 859 859 CD 10_1101-2021_01_06_425584 617 10 is be VBZ 10_1101-2021_01_06_425584 617 11 also also RB 10_1101-2021_01_06_425584 617 12 shown show VBN 10_1101-2021_01_06_425584 617 13 . . . 10_1101-2021_01_06_425584 618 1 The the DT 10_1101-2021_01_06_425584 618 2 fragments fragment NNS 10_1101-2021_01_06_425584 618 3 of of IN 10_1101-2021_01_06_425584 618 4 M2M_59 M2M_59 NNP 10_1101-2021_01_06_425584 618 5 colored color VBN 10_1101-2021_01_06_425584 618 6 in in IN 10_1101-2021_01_06_425584 618 7 red red NN 10_1101-2021_01_06_425584 618 8 are be VBP 10_1101-2021_01_06_425584 618 9 characteristic characteristic JJ 10_1101-2021_01_06_425584 618 10 of of IN 10_1101-2021_01_06_425584 618 11 a a DT 10_1101-2021_01_06_425584 618 12 phenylalanine phenylalanine NN 10_1101-2021_01_06_425584 618 13 core core NN 10_1101-2021_01_06_425584 618 14 860 860 CD 10_1101-2021_01_06_425584 618 15 ( ( -LRB- 10_1101-2021_01_06_425584 618 16 Heuristic Heuristic NNP 10_1101-2021_01_06_425584 618 17 and and CC 10_1101-2021_01_06_425584 618 18 Quantum Quantum NNP 10_1101-2021_01_06_425584 618 19 Chemical Chemical NNP 10_1101-2021_01_06_425584 618 20 predictions prediction NNS 10_1101-2021_01_06_425584 618 21 by by IN 10_1101-2021_01_06_425584 618 22 www.mzCloud.org www.mzcloud.org NN 10_1101-2021_01_06_425584 618 23 ) ) -RRB- 10_1101-2021_01_06_425584 618 24 . . . 10_1101-2021_01_06_425584 619 1 ( ( -LRB- 10_1101-2021_01_06_425584 619 2 D d NN 10_1101-2021_01_06_425584 619 3 ) ) -RRB- 10_1101-2021_01_06_425584 619 4 Features feature NNS 10_1101-2021_01_06_425584 619 5 associated associate VBD 10_1101-2021_01_06_425584 619 6 861 861 CD 10_1101-2021_01_06_425584 619 7 with with IN 10_1101-2021_01_06_425584 619 8 M2M_59 M2M_59 NNP 10_1101-2021_01_06_425584 619 9 using use VBG 10_1101-2021_01_06_425584 619 10 MS1 MS1 NNP 10_1101-2021_01_06_425584 619 11 visualization visualization NN 10_1101-2021_01_06_425584 619 12 in in IN 10_1101-2021_01_06_425584 619 13 www.ms2lda.org www.ms2lda.org NN 10_1101-2021_01_06_425584 619 14 . . . 10_1101-2021_01_06_425584 620 1 In in IN 10_1101-2021_01_06_425584 620 2 GNPS GNPS NNP 10_1101-2021_01_06_425584 620 3 ’s ’s POS 10_1101-2021_01_06_425584 620 4 clusters cluster NNS 10_1101-2021_01_06_425584 620 5 ( ( -LRB- 10_1101-2021_01_06_425584 620 6 A a NN 10_1101-2021_01_06_425584 620 7 and and CC 10_1101-2021_01_06_425584 620 8 C C NNP 10_1101-2021_01_06_425584 620 9 ) ) -RRB- 10_1101-2021_01_06_425584 620 10 , , , 10_1101-2021_01_06_425584 620 11 the the DT 10_1101-2021_01_06_425584 620 12 862 862 CD 10_1101-2021_01_06_425584 620 13 node node NN 10_1101-2021_01_06_425584 620 14 ’s ’s POS 10_1101-2021_01_06_425584 620 15 color color NN 10_1101-2021_01_06_425584 620 16 denotes denote VBZ 10_1101-2021_01_06_425584 620 17 the the DT 10_1101-2021_01_06_425584 620 18 chemical chemical NN 10_1101-2021_01_06_425584 620 19 class class NN 10_1101-2021_01_06_425584 620 20 assigned assign VBN 10_1101-2021_01_06_425584 620 21 to to IN 10_1101-2021_01_06_425584 620 22 the the DT 10_1101-2021_01_06_425584 620 23 cluster cluster NN 10_1101-2021_01_06_425584 620 24 . . . 10_1101-2021_01_06_425584 621 1 The the DT 10_1101-2021_01_06_425584 621 2 thickness thickness NN 10_1101-2021_01_06_425584 621 3 of of IN 10_1101-2021_01_06_425584 621 4 the the DT 10_1101-2021_01_06_425584 621 5 edge edge NN 10_1101-2021_01_06_425584 621 6 863 863 CD 10_1101-2021_01_06_425584 621 7 ( ( -LRB- 10_1101-2021_01_06_425584 621 8 connectivity connectivity NN 10_1101-2021_01_06_425584 621 9 ) ) -RRB- 10_1101-2021_01_06_425584 621 10 indicates indicate VBZ 10_1101-2021_01_06_425584 621 11 the the DT 10_1101-2021_01_06_425584 621 12 cosine cosine NN 10_1101-2021_01_06_425584 621 13 score score NN 10_1101-2021_01_06_425584 621 14 ( ( -LRB- 10_1101-2021_01_06_425584 621 15 MS2 MS2 NNP 10_1101-2021_01_06_425584 621 16 similarity similarity NN 10_1101-2021_01_06_425584 621 17 ) ) -RRB- 10_1101-2021_01_06_425584 621 18 . . . 10_1101-2021_01_06_425584 622 1 The the DT 10_1101-2021_01_06_425584 622 2 m m NNP 10_1101-2021_01_06_425584 622 3 / / SYM 10_1101-2021_01_06_425584 622 4 z z NN 10_1101-2021_01_06_425584 622 5 value value NN 10_1101-2021_01_06_425584 622 6 of of IN 10_1101-2021_01_06_425584 622 7 the the DT 10_1101-2021_01_06_425584 622 8 feature feature NN 10_1101-2021_01_06_425584 622 9 is be VBZ 10_1101-2021_01_06_425584 622 10 shown show VBN 10_1101-2021_01_06_425584 622 11 864 864 CD 10_1101-2021_01_06_425584 622 12 inside inside IN 10_1101-2021_01_06_425584 622 13 the the DT 10_1101-2021_01_06_425584 622 14 node node NN 10_1101-2021_01_06_425584 622 15 and and CC 10_1101-2021_01_06_425584 622 16 is be VBZ 10_1101-2021_01_06_425584 622 17 proportional proportional JJ 10_1101-2021_01_06_425584 622 18 to to IN 10_1101-2021_01_06_425584 622 19 the the DT 10_1101-2021_01_06_425584 622 20 size size NN 10_1101-2021_01_06_425584 622 21 of of IN 10_1101-2021_01_06_425584 622 22 the the DT 10_1101-2021_01_06_425584 622 23 node node NN 10_1101-2021_01_06_425584 622 24 . . . 10_1101-2021_01_06_425584 623 1 Significant significant JJ 10_1101-2021_01_06_425584 623 2 differential differential NN 10_1101-2021_01_06_425584 623 3 abundant abundant JJ 10_1101-2021_01_06_425584 623 4 865 865 CD 10_1101-2021_01_06_425584 623 5 features feature NNS 10_1101-2021_01_06_425584 623 6 among among IN 10_1101-2021_01_06_425584 623 7 simulated simulated JJ 10_1101-2021_01_06_425584 623 8 diabetes diabete NNS 10_1101-2021_01_06_425584 623 9 ( ( -LRB- 10_1101-2021_01_06_425584 623 10 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 623 11 ) ) -RRB- 10_1101-2021_01_06_425584 623 12 and and CC 10_1101-2021_01_06_425584 623 13 control control NN 10_1101-2021_01_06_425584 623 14 ( ( -LRB- 10_1101-2021_01_06_425584 623 15 NG NG NNP 10_1101-2021_01_06_425584 623 16 ) ) -RRB- 10_1101-2021_01_06_425584 623 17 groups group NNS 10_1101-2021_01_06_425584 623 18 are be VBP 10_1101-2021_01_06_425584 623 19 indicated indicate VBN 10_1101-2021_01_06_425584 623 20 with with IN 10_1101-2021_01_06_425584 623 21 an an DT 10_1101-2021_01_06_425584 623 22 866 866 CD 10_1101-2021_01_06_425584 623 23 asterisk asterisk NN 10_1101-2021_01_06_425584 623 24 ( ( -LRB- 10_1101-2021_01_06_425584 623 25 p p NN 10_1101-2021_01_06_425584 623 26 - - HYPH 10_1101-2021_01_06_425584 623 27 value value NN 10_1101-2021_01_06_425584 623 28 < < XX 10_1101-2021_01_06_425584 623 29 0.05 0.05 CD 10_1101-2021_01_06_425584 623 30 ) ) -RRB- 10_1101-2021_01_06_425584 623 31 . . . 10_1101-2021_01_06_425584 624 1 In in IN 10_1101-2021_01_06_425584 624 2 MS2LDA MS2LDA NNP 10_1101-2021_01_06_425584 624 3 ’s ’s POS 10_1101-2021_01_06_425584 624 4 nodes node NNS 10_1101-2021_01_06_425584 624 5 ( ( -LRB- 10_1101-2021_01_06_425584 624 6 B b NN 10_1101-2021_01_06_425584 624 7 and and CC 10_1101-2021_01_06_425584 624 8 D D NNP 10_1101-2021_01_06_425584 624 9 ) ) -RRB- 10_1101-2021_01_06_425584 624 10 , , , 10_1101-2021_01_06_425584 624 11 the the DT 10_1101-2021_01_06_425584 624 12 green green NNP 10_1101-2021_01_06_425584 624 13 node node RB 10_1101-2021_01_06_425584 624 14 represents represent VBZ 10_1101-2021_01_06_425584 624 15 the the DT 10_1101-2021_01_06_425584 624 16 M2 M2 NNP 10_1101-2021_01_06_425584 624 17 M M NNP 10_1101-2021_01_06_425584 624 18 and and CC 10_1101-2021_01_06_425584 624 19 867 867 CD 10_1101-2021_01_06_425584 624 20 squares square NNS 10_1101-2021_01_06_425584 624 21 indicate indicate VBP 10_1101-2021_01_06_425584 624 22 individual individual JJ 10_1101-2021_01_06_425584 624 23 features feature NNS 10_1101-2021_01_06_425584 624 24 . . . 10_1101-2021_01_06_425584 625 1 Edges edge NNS 10_1101-2021_01_06_425584 625 2 represent represent VBP 10_1101-2021_01_06_425584 625 3 connections connection NNS 10_1101-2021_01_06_425584 625 4 to to IN 10_1101-2021_01_06_425584 625 5 M2M. m2m. VB 10_1101-2021_01_06_425584 626 1 Significant significant JJ 10_1101-2021_01_06_425584 626 2 differential differential NN 10_1101-2021_01_06_425584 626 3 868 868 CD 10_1101-2021_01_06_425584 626 4 abundant abundant JJ 10_1101-2021_01_06_425584 626 5 features feature NNS 10_1101-2021_01_06_425584 626 6 among among IN 10_1101-2021_01_06_425584 626 7 groups group NNS 10_1101-2021_01_06_425584 626 8 are be VBP 10_1101-2021_01_06_425584 626 9 indicated indicate VBN 10_1101-2021_01_06_425584 626 10 with with IN 10_1101-2021_01_06_425584 626 11 an an DT 10_1101-2021_01_06_425584 626 12 asterisk asterisk NN 10_1101-2021_01_06_425584 626 13 ( ( -LRB- 10_1101-2021_01_06_425584 626 14 p p NN 10_1101-2021_01_06_425584 626 15 - - HYPH 10_1101-2021_01_06_425584 626 16 value value NN 10_1101-2021_01_06_425584 626 17 < < XX 10_1101-2021_01_06_425584 626 18 0.05 0.05 CD 10_1101-2021_01_06_425584 626 19 ) ) -RRB- 10_1101-2021_01_06_425584 626 20 . . . 10_1101-2021_01_06_425584 627 1 Abbreviations abbreviation NNS 10_1101-2021_01_06_425584 627 2 : : : 10_1101-2021_01_06_425584 627 3 869 869 CD 10_1101-2021_01_06_425584 627 4 M2 M2 NNP 10_1101-2021_01_06_425584 627 5 M M NNP 10_1101-2021_01_06_425584 627 6 , , , 10_1101-2021_01_06_425584 627 7 mass2motif mass2motif NNP 10_1101-2021_01_06_425584 627 8 ; ; : 10_1101-2021_01_06_425584 627 9 FC fc NN 10_1101-2021_01_06_425584 627 10 , , , 10_1101-2021_01_06_425584 627 11 fold fold VB 10_1101-2021_01_06_425584 627 12 change change NN 10_1101-2021_01_06_425584 627 13 ; ; : 10_1101-2021_01_06_425584 627 14 NG NG NNP 10_1101-2021_01_06_425584 627 15 , , , 10_1101-2021_01_06_425584 627 16 normal normal JJ 10_1101-2021_01_06_425584 627 17 glucose glucose NN 10_1101-2021_01_06_425584 627 18 ; ; : 10_1101-2021_01_06_425584 627 19 HG HG NNP 10_1101-2021_01_06_425584 627 20 , , , 10_1101-2021_01_06_425584 627 21 high high JJ 10_1101-2021_01_06_425584 627 22 glucose glucose NN 10_1101-2021_01_06_425584 627 23 ; ; : 10_1101-2021_01_06_425584 627 24 HI hi UH 10_1101-2021_01_06_425584 627 25 , , , 10_1101-2021_01_06_425584 627 26 high high JJ 10_1101-2021_01_06_425584 627 27 insulin insulin NN 10_1101-2021_01_06_425584 627 28 . . . 10_1101-2021_01_06_425584 628 1 870 870 CD 10_1101-2021_01_06_425584 628 2 Chemical Chemical NNP 10_1101-2021_01_06_425584 628 3 structures structure NNS 10_1101-2021_01_06_425584 628 4 were be VBD 10_1101-2021_01_06_425584 628 5 drawn draw VBN 10_1101-2021_01_06_425584 628 6 by by IN 10_1101-2021_01_06_425584 628 7 ChemDraw ChemDraw NNP 10_1101-2021_01_06_425584 628 8 Professional Professional NNP 10_1101-2021_01_06_425584 628 9 version version NN 10_1101-2021_01_06_425584 628 10 16.0.1.4 16.0.1.4 NN 10_1101-2021_01_06_425584 628 11 . . . 10_1101-2021_01_06_425584 629 1 871 871 CD 10_1101-2021_01_06_425584 629 2 872 872 CD 10_1101-2021_01_06_425584 629 3 Figure figure NN 10_1101-2021_01_06_425584 629 4 5 5 CD 10_1101-2021_01_06_425584 629 5 . . . 10_1101-2021_01_06_425584 630 1 Simulated simulate VBN 10_1101-2021_01_06_425584 630 2 diabetes diabete NNS 10_1101-2021_01_06_425584 630 3 induced induce VBD 10_1101-2021_01_06_425584 630 4 changes change NNS 10_1101-2021_01_06_425584 630 5 in in IN 10_1101-2021_01_06_425584 630 6 the the DT 10_1101-2021_01_06_425584 630 7 proteome proteome NN 10_1101-2021_01_06_425584 630 8 of of IN 10_1101-2021_01_06_425584 630 9 bovine bovine JJ 10_1101-2021_01_06_425584 630 10 coronary coronary JJ 10_1101-2021_01_06_425584 630 11 artery artery NN 10_1101-2021_01_06_425584 630 12 873 873 CD 10_1101-2021_01_06_425584 630 13 endothelial endothelial JJ 10_1101-2021_01_06_425584 630 14 cells cell NNS 10_1101-2021_01_06_425584 630 15 ( ( -LRB- 10_1101-2021_01_06_425584 630 16 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 630 17 ) ) -RRB- 10_1101-2021_01_06_425584 630 18 . . . 10_1101-2021_01_06_425584 631 1 ( ( -LRB- 10_1101-2021_01_06_425584 631 2 A a DT 10_1101-2021_01_06_425584 631 3 ) ) -RRB- 10_1101-2021_01_06_425584 631 4 Principal Principal NNP 10_1101-2021_01_06_425584 631 5 Component Component NNP 10_1101-2021_01_06_425584 631 6 Analysis Analysis NNP 10_1101-2021_01_06_425584 631 7 ( ( -LRB- 10_1101-2021_01_06_425584 631 8 PCA PCA NNP 10_1101-2021_01_06_425584 631 9 ) ) -RRB- 10_1101-2021_01_06_425584 631 10 of of IN 10_1101-2021_01_06_425584 631 11 LC LC NNP 10_1101-2021_01_06_425584 631 12 - - HYPH 10_1101-2021_01_06_425584 631 13 SWATH SWATH NNP 10_1101-2021_01_06_425584 631 14 - - HYPH 10_1101-2021_01_06_425584 631 15 MS2 MS2 NNP 10_1101-2021_01_06_425584 631 16 874 874 CD 10_1101-2021_01_06_425584 631 17 datasets dataset NNS 10_1101-2021_01_06_425584 631 18 . . . 10_1101-2021_01_06_425584 632 1 Data datum NNS 10_1101-2021_01_06_425584 632 2 was be VBD 10_1101-2021_01_06_425584 632 3 log log NN 10_1101-2021_01_06_425584 632 4 transformed transform VBN 10_1101-2021_01_06_425584 632 5 without without IN 10_1101-2021_01_06_425584 632 6 scaling scale VBG 10_1101-2021_01_06_425584 632 7 . . . 10_1101-2021_01_06_425584 633 1 Shade shade NN 10_1101-2021_01_06_425584 633 2 areas area NNS 10_1101-2021_01_06_425584 633 3 depict depict VBP 10_1101-2021_01_06_425584 633 4 the the DT 10_1101-2021_01_06_425584 633 5 95 95 CD 10_1101-2021_01_06_425584 633 6 % % NN 10_1101-2021_01_06_425584 633 7 confidence confidence NN 10_1101-2021_01_06_425584 633 8 875 875 CD 10_1101-2021_01_06_425584 633 9 intervals interval NNS 10_1101-2021_01_06_425584 633 10 . . . 10_1101-2021_01_06_425584 634 1 No no DT 10_1101-2021_01_06_425584 634 2 scaling scaling NN 10_1101-2021_01_06_425584 634 3 was be VBD 10_1101-2021_01_06_425584 634 4 used use VBN 10_1101-2021_01_06_425584 634 5 . . . 10_1101-2021_01_06_425584 635 1 ( ( -LRB- 10_1101-2021_01_06_425584 635 2 B b NN 10_1101-2021_01_06_425584 635 3 ) ) -RRB- 10_1101-2021_01_06_425584 635 4 Volcano Volcano NNP 10_1101-2021_01_06_425584 635 5 plot plot NN 10_1101-2021_01_06_425584 635 6 of of IN 10_1101-2021_01_06_425584 635 7 all all DT 10_1101-2021_01_06_425584 635 8 quantified quantify VBN 10_1101-2021_01_06_425584 635 9 proteins protein NNS 10_1101-2021_01_06_425584 635 10 ( ( -LRB- 10_1101-2021_01_06_425584 635 11 Quantile Quantile NNP 10_1101-2021_01_06_425584 635 12 normalization normalization NN 10_1101-2021_01_06_425584 635 13 ) ) -RRB- 10_1101-2021_01_06_425584 635 14 876 876 CD 10_1101-2021_01_06_425584 635 15 displaying display VBG 10_1101-2021_01_06_425584 635 16 differences difference NNS 10_1101-2021_01_06_425584 635 17 in in IN 10_1101-2021_01_06_425584 635 18 relative relative JJ 10_1101-2021_01_06_425584 635 19 abundance abundance NN 10_1101-2021_01_06_425584 635 20 ( ( -LRB- 10_1101-2021_01_06_425584 635 21 > > XX 10_1101-2021_01_06_425584 635 22 + + SYM 10_1101-2021_01_06_425584 635 23 /-20 /-20 CD 10_1101-2021_01_06_425584 635 24 % % NN 10_1101-2021_01_06_425584 635 25 change change NN 10_1101-2021_01_06_425584 635 26 , , , 10_1101-2021_01_06_425584 635 27 < < XX 10_1101-2021_01_06_425584 635 28 0.05 0.05 CD 10_1101-2021_01_06_425584 635 29 p p NN 10_1101-2021_01_06_425584 635 30 - - HYPH 10_1101-2021_01_06_425584 635 31 value value NN 10_1101-2021_01_06_425584 635 32 cut cut NN 10_1101-2021_01_06_425584 635 33 - - HYPH 10_1101-2021_01_06_425584 635 34 offs off NNS 10_1101-2021_01_06_425584 635 35 ) ) -RRB- 10_1101-2021_01_06_425584 635 36 between between IN 10_1101-2021_01_06_425584 635 37 877 877 CD 10_1101-2021_01_06_425584 635 38 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 635 39 cultured cultured JJ 10_1101-2021_01_06_425584 635 40 in in IN 10_1101-2021_01_06_425584 635 41 control control NN 10_1101-2021_01_06_425584 635 42 ( ( -LRB- 10_1101-2021_01_06_425584 635 43 NG NG NNP 10_1101-2021_01_06_425584 635 44 ) ) -RRB- 10_1101-2021_01_06_425584 635 45 media medium NNS 10_1101-2021_01_06_425584 635 46 and and CC 10_1101-2021_01_06_425584 635 47 simulated simulate VBN 10_1101-2021_01_06_425584 635 48 diabetes diabetes NN 10_1101-2021_01_06_425584 635 49 ( ( -LRB- 10_1101-2021_01_06_425584 635 50 HG+ HG+ NNP 10_1101-2021_01_06_425584 635 51 HI HI NNP 10_1101-2021_01_06_425584 635 52 ) ) -RRB- 10_1101-2021_01_06_425584 635 53 for for IN 10_1101-2021_01_06_425584 635 54 twelve twelve CD 10_1101-2021_01_06_425584 635 55 days day NNS 10_1101-2021_01_06_425584 635 56 . . . 10_1101-2021_01_06_425584 636 1 Values value NNS 10_1101-2021_01_06_425584 636 2 878 878 CD 10_1101-2021_01_06_425584 636 3 ( ( -LRB- 10_1101-2021_01_06_425584 636 4 dots dot NNS 10_1101-2021_01_06_425584 636 5 ) ) -RRB- 10_1101-2021_01_06_425584 636 6 represent represent VBP 10_1101-2021_01_06_425584 636 7 the the DT 10_1101-2021_01_06_425584 636 8 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 636 9 / / SYM 10_1101-2021_01_06_425584 636 10 NG NG NNP 10_1101-2021_01_06_425584 636 11 ratio ratio NN 10_1101-2021_01_06_425584 636 12 for for IN 10_1101-2021_01_06_425584 636 13 all all DT 10_1101-2021_01_06_425584 636 14 proteins protein NNS 10_1101-2021_01_06_425584 636 15 . . . 10_1101-2021_01_06_425584 637 1 Red red JJ 10_1101-2021_01_06_425584 637 2 and and CC 10_1101-2021_01_06_425584 637 3 blue blue JJ 10_1101-2021_01_06_425584 637 4 dots dot NNS 10_1101-2021_01_06_425584 637 5 denote denote VBP 10_1101-2021_01_06_425584 637 6 downregulated downregulate VBD 10_1101-2021_01_06_425584 637 7 879 879 CD 10_1101-2021_01_06_425584 637 8 and and CC 10_1101-2021_01_06_425584 637 9 upregulated upregulated JJ 10_1101-2021_01_06_425584 637 10 proteins protein NNS 10_1101-2021_01_06_425584 637 11 in in IN 10_1101-2021_01_06_425584 637 12 the the DT 10_1101-2021_01_06_425584 637 13 HG HG NNP 10_1101-2021_01_06_425584 637 14 + + CC 10_1101-2021_01_06_425584 637 15 HI HI NNP 10_1101-2021_01_06_425584 637 16 group group NN 10_1101-2021_01_06_425584 637 17 vs. vs. IN 10_1101-2021_01_06_425584 637 18 NG NG NNP 10_1101-2021_01_06_425584 637 19 group group NN 10_1101-2021_01_06_425584 637 20 , , , 10_1101-2021_01_06_425584 637 21 respectively respectively RB 10_1101-2021_01_06_425584 637 22 . . . 10_1101-2021_01_06_425584 638 1 ( ( -LRB- 10_1101-2021_01_06_425584 638 2 C C NNP 10_1101-2021_01_06_425584 638 3 ) ) -RRB- 10_1101-2021_01_06_425584 638 4 HeatMap HeatMap NNP 10_1101-2021_01_06_425584 638 5 of of IN 10_1101-2021_01_06_425584 638 6 the the DT 10_1101-2021_01_06_425584 638 7 880 880 CD 10_1101-2021_01_06_425584 638 8 top top JJ 10_1101-2021_01_06_425584 638 9 50 50 CD 10_1101-2021_01_06_425584 638 10 metabolites metabolite NNS 10_1101-2021_01_06_425584 638 11 ranked rank VBN 10_1101-2021_01_06_425584 638 12 by by IN 10_1101-2021_01_06_425584 638 13 t t NN 10_1101-2021_01_06_425584 638 14 - - HYPH 10_1101-2021_01_06_425584 638 15 test test NN 10_1101-2021_01_06_425584 638 16 . . . 10_1101-2021_01_06_425584 639 1 Protein Protein NNP 10_1101-2021_01_06_425584 639 2 - - HYPH 10_1101-2021_01_06_425584 639 3 Protein Protein NNP 10_1101-2021_01_06_425584 639 4 interactome interactome NN 10_1101-2021_01_06_425584 639 5 ( ( -LRB- 10_1101-2021_01_06_425584 639 6 > > XX 10_1101-2021_01_06_425584 639 7 0.9 0.9 CD 10_1101-2021_01_06_425584 639 8 confidence confidence NN 10_1101-2021_01_06_425584 639 9 ) ) -RRB- 10_1101-2021_01_06_425584 639 10 using use VBG 10_1101-2021_01_06_425584 639 11 the the DT 10_1101-2021_01_06_425584 639 12 list list NN 10_1101-2021_01_06_425584 639 13 881 881 CD 10_1101-2021_01_06_425584 639 14 of of IN 10_1101-2021_01_06_425584 639 15 proteins protein NNS 10_1101-2021_01_06_425584 639 16 with with IN 10_1101-2021_01_06_425584 639 17 increased increase VBN 10_1101-2021_01_06_425584 639 18 abundance abundance NN 10_1101-2021_01_06_425584 639 19 ( ( -LRB- 10_1101-2021_01_06_425584 639 20 D D NNP 10_1101-2021_01_06_425584 639 21 ) ) -RRB- 10_1101-2021_01_06_425584 639 22 and and CC 10_1101-2021_01_06_425584 639 23 reduced reduce VBN 10_1101-2021_01_06_425584 639 24 abundance abundance NN 10_1101-2021_01_06_425584 639 25 ( ( -LRB- 10_1101-2021_01_06_425584 639 26 E e NN 10_1101-2021_01_06_425584 639 27 ) ) -RRB- 10_1101-2021_01_06_425584 639 28 in in IN 10_1101-2021_01_06_425584 639 29 the the DT 10_1101-2021_01_06_425584 639 30 HG HG NNP 10_1101-2021_01_06_425584 639 31 + + CC 10_1101-2021_01_06_425584 639 32 HI HI NNP 10_1101-2021_01_06_425584 639 33 group group NN 10_1101-2021_01_06_425584 639 34 . . . 10_1101-2021_01_06_425584 640 1 882 882 CD 10_1101-2021_01_06_425584 640 2 Colored colored JJ 10_1101-2021_01_06_425584 640 3 circles circle NNS 10_1101-2021_01_06_425584 640 4 denote denote NN 10_1101-2021_01_06_425584 640 5 modules module NNS 10_1101-2021_01_06_425584 640 6 or or CC 10_1101-2021_01_06_425584 640 7 clusters cluster NNS 10_1101-2021_01_06_425584 640 8 which which WDT 10_1101-2021_01_06_425584 640 9 may may MD 10_1101-2021_01_06_425584 640 10 represent represent VB 10_1101-2021_01_06_425584 640 11 relevant relevant JJ 10_1101-2021_01_06_425584 640 12 complexes complex NNS 10_1101-2021_01_06_425584 640 13 or or CC 10_1101-2021_01_06_425584 640 14 functional functional JJ 10_1101-2021_01_06_425584 640 15 883 883 CD 10_1101-2021_01_06_425584 640 16 units unit NNS 10_1101-2021_01_06_425584 640 17 . . . 10_1101-2021_01_06_425584 641 1 The the DT 10_1101-2021_01_06_425584 641 2 input input NN 10_1101-2021_01_06_425584 641 3 proteins protein NNS 10_1101-2021_01_06_425584 641 4 are be VBP 10_1101-2021_01_06_425584 641 5 illustrated illustrate VBN 10_1101-2021_01_06_425584 641 6 with with IN 10_1101-2021_01_06_425584 641 7 a a DT 10_1101-2021_01_06_425584 641 8 blue blue JJ 10_1101-2021_01_06_425584 641 9 shade shade NN 10_1101-2021_01_06_425584 641 10 and and CC 10_1101-2021_01_06_425584 641 11 the the DT 10_1101-2021_01_06_425584 641 12 gene gene NN 10_1101-2021_01_06_425584 641 13 ID ID NNP 10_1101-2021_01_06_425584 641 14 is be VBZ 10_1101-2021_01_06_425584 641 15 also also RB 10_1101-2021_01_06_425584 641 16 shown show VBN 10_1101-2021_01_06_425584 641 17 . . . 10_1101-2021_01_06_425584 642 1 The the DT 10_1101-2021_01_06_425584 642 2 884 884 CD 10_1101-2021_01_06_425584 642 3 most most RBS 10_1101-2021_01_06_425584 642 4 representative representative JJ 10_1101-2021_01_06_425584 642 5 pathway pathway NN 10_1101-2021_01_06_425584 642 6 ( ( -LRB- 10_1101-2021_01_06_425584 642 7 containing contain VBG 10_1101-2021_01_06_425584 642 8 more more JJR 10_1101-2021_01_06_425584 642 9 input input NN 10_1101-2021_01_06_425584 642 10 proteins protein NNS 10_1101-2021_01_06_425584 642 11 ) ) -RRB- 10_1101-2021_01_06_425584 642 12 for for IN 10_1101-2021_01_06_425584 642 13 all all DT 10_1101-2021_01_06_425584 642 14 modules module NNS 10_1101-2021_01_06_425584 642 15 is be VBZ 10_1101-2021_01_06_425584 642 16 indicated indicate VBN 10_1101-2021_01_06_425584 642 17 in in IN 10_1101-2021_01_06_425584 642 18 blue blue JJ 10_1101-2021_01_06_425584 642 19 885 885 CD 10_1101-2021_01_06_425584 642 20 letters letter NNS 10_1101-2021_01_06_425584 642 21 . . . 10_1101-2021_01_06_425584 643 1 Abbreviations abbreviation NNS 10_1101-2021_01_06_425584 643 2 : : : 10_1101-2021_01_06_425584 643 3 NG NG NNP 10_1101-2021_01_06_425584 643 4 , , , 10_1101-2021_01_06_425584 643 5 normal normal JJ 10_1101-2021_01_06_425584 643 6 glucose glucose NN 10_1101-2021_01_06_425584 643 7 ; ; : 10_1101-2021_01_06_425584 643 8 HG HG NNP 10_1101-2021_01_06_425584 643 9 , , , 10_1101-2021_01_06_425584 643 10 high high JJ 10_1101-2021_01_06_425584 643 11 glucose glucose NN 10_1101-2021_01_06_425584 643 12 ; ; : 10_1101-2021_01_06_425584 643 13 HI hi UH 10_1101-2021_01_06_425584 643 14 , , , 10_1101-2021_01_06_425584 643 15 high high JJ 10_1101-2021_01_06_425584 643 16 insulin insulin NN 10_1101-2021_01_06_425584 643 17 . . . 10_1101-2021_01_06_425584 644 1 886 886 CD 10_1101-2021_01_06_425584 644 2 887 887 CD 10_1101-2021_01_06_425584 644 3 Figure figure NN 10_1101-2021_01_06_425584 644 4 6 6 CD 10_1101-2021_01_06_425584 644 5 . . . 10_1101-2021_01_06_425584 645 1 3D 3d JJ 10_1101-2021_01_06_425584 645 2 Integrative integrative JJ 10_1101-2021_01_06_425584 645 3 network network NN 10_1101-2021_01_06_425584 645 4 of of IN 10_1101-2021_01_06_425584 645 5 the the DT 10_1101-2021_01_06_425584 645 6 proteomic proteomic JJ 10_1101-2021_01_06_425584 645 7 and and CC 10_1101-2021_01_06_425584 645 8 metabolomic metabolomic JJ 10_1101-2021_01_06_425584 645 9 perturbations perturbation NNS 10_1101-2021_01_06_425584 645 10 caused cause VBD 10_1101-2021_01_06_425584 645 11 888 888 CD 10_1101-2021_01_06_425584 645 12 by by IN 10_1101-2021_01_06_425584 645 13 simulated simulated JJ 10_1101-2021_01_06_425584 645 14 diabetes diabete NNS 10_1101-2021_01_06_425584 645 15 in in IN 10_1101-2021_01_06_425584 645 16 bovine bovine JJ 10_1101-2021_01_06_425584 645 17 coronary coronary JJ 10_1101-2021_01_06_425584 645 18 artery artery NN 10_1101-2021_01_06_425584 645 19 endothelial endothelial JJ 10_1101-2021_01_06_425584 645 20 cells cell NNS 10_1101-2021_01_06_425584 645 21 ( ( -LRB- 10_1101-2021_01_06_425584 645 22 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 645 23 ) ) -RRB- 10_1101-2021_01_06_425584 645 24 . . . 10_1101-2021_01_06_425584 646 1 Composite composite JJ 10_1101-2021_01_06_425584 646 2 889 889 CD 10_1101-2021_01_06_425584 646 3 protein protein NN 10_1101-2021_01_06_425584 646 4 - - HYPH 10_1101-2021_01_06_425584 646 5 metabolite metabolite JJ 10_1101-2021_01_06_425584 646 6 network network NN 10_1101-2021_01_06_425584 646 7 created create VBN 10_1101-2021_01_06_425584 646 8 by by IN 10_1101-2021_01_06_425584 646 9 OmicsNet OmicsNet NNP 10_1101-2021_01_06_425584 646 10 using use VBG 10_1101-2021_01_06_425584 646 11 the the DT 10_1101-2021_01_06_425584 646 12 up up RB 10_1101-2021_01_06_425584 646 13 - - HYPH 10_1101-2021_01_06_425584 646 14 regulated regulated JJ 10_1101-2021_01_06_425584 646 15 proteins protein NNS 10_1101-2021_01_06_425584 646 16 ( ( -LRB- 10_1101-2021_01_06_425584 646 17 red red JJ 10_1101-2021_01_06_425584 646 18 nodes node NNS 10_1101-2021_01_06_425584 646 19 ) ) -RRB- 10_1101-2021_01_06_425584 646 20 and and CC 10_1101-2021_01_06_425584 646 21 890 890 CD 10_1101-2021_01_06_425584 646 22 .CC .CC : 10_1101-2021_01_06_425584 646 23 - - HYPH 10_1101-2021_01_06_425584 646 24 BY by IN 10_1101-2021_01_06_425584 646 25 - - HYPH 10_1101-2021_01_06_425584 646 26 NC NC NNP 10_1101-2021_01_06_425584 646 27 - - HYPH 10_1101-2021_01_06_425584 646 28 ND ND NNP 10_1101-2021_01_06_425584 646 29 4.0 4.0 CD 10_1101-2021_01_06_425584 646 30 International International NNP 10_1101-2021_01_06_425584 646 31 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 646 32 under under IN 10_1101-2021_01_06_425584 646 33 a a DT 10_1101-2021_01_06_425584 646 34 ( ( -LRB- 10_1101-2021_01_06_425584 646 35 which which WDT 10_1101-2021_01_06_425584 646 36 was be VBD 10_1101-2021_01_06_425584 646 37 not not RB 10_1101-2021_01_06_425584 646 38 certified certify VBN 10_1101-2021_01_06_425584 646 39 by by IN 10_1101-2021_01_06_425584 646 40 peer peer NN 10_1101-2021_01_06_425584 646 41 review review NN 10_1101-2021_01_06_425584 646 42 ) ) -RRB- 10_1101-2021_01_06_425584 646 43 is be VBZ 10_1101-2021_01_06_425584 646 44 the the DT 10_1101-2021_01_06_425584 646 45 author author NN 10_1101-2021_01_06_425584 646 46 / / SYM 10_1101-2021_01_06_425584 646 47 funder funder NN 10_1101-2021_01_06_425584 646 48 , , , 10_1101-2021_01_06_425584 646 49 who who WP 10_1101-2021_01_06_425584 646 50 has have VBZ 10_1101-2021_01_06_425584 646 51 granted grant VBN 10_1101-2021_01_06_425584 646 52 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 646 53 a a DT 10_1101-2021_01_06_425584 646 54 license license NN 10_1101-2021_01_06_425584 646 55 to to TO 10_1101-2021_01_06_425584 646 56 display display VB 10_1101-2021_01_06_425584 646 57 the the DT 10_1101-2021_01_06_425584 646 58 preprint preprint NN 10_1101-2021_01_06_425584 646 59 in in IN 10_1101-2021_01_06_425584 646 60 perpetuity perpetuity NN 10_1101-2021_01_06_425584 646 61 . . . 10_1101-2021_01_06_425584 647 1 It -PRON- PRP 10_1101-2021_01_06_425584 647 2 is be VBZ 10_1101-2021_01_06_425584 647 3 made make VBN 10_1101-2021_01_06_425584 647 4 The the DT 10_1101-2021_01_06_425584 647 5 copyright copyright NN 10_1101-2021_01_06_425584 647 6 holder holder NN 10_1101-2021_01_06_425584 647 7 for for IN 10_1101-2021_01_06_425584 647 8 this this DT 10_1101-2021_01_06_425584 647 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 647 10 version version NN 10_1101-2021_01_06_425584 647 11 posted post VBD 10_1101-2021_01_06_425584 647 12 January January NNP 10_1101-2021_01_06_425584 647 13 8 8 CD 10_1101-2021_01_06_425584 647 14 , , , 10_1101-2021_01_06_425584 647 15 2021 2021 CD 10_1101-2021_01_06_425584 647 16 . . . 10_1101-2021_01_06_425584 647 17 ; ; : 10_1101-2021_01_06_425584 647 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 647 19 : : : 10_1101-2021_01_06_425584 647 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 647 21 preprint preprint NN 10_1101-2021_01_06_425584 647 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 647 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 647 24 29 29 CD 10_1101-2021_01_06_425584 647 25 metabolites metabolite NNS 10_1101-2021_01_06_425584 647 26 ( ( -LRB- 10_1101-2021_01_06_425584 647 27 magenta magenta NNP 10_1101-2021_01_06_425584 647 28 nodes node NNS 10_1101-2021_01_06_425584 647 29 ) ) -RRB- 10_1101-2021_01_06_425584 647 30 in in IN 10_1101-2021_01_06_425584 647 31 the the DT 10_1101-2021_01_06_425584 647 32 HG HG NNP 10_1101-2021_01_06_425584 647 33 + + CC 10_1101-2021_01_06_425584 647 34 HI HI NNP 10_1101-2021_01_06_425584 647 35 group group NN 10_1101-2021_01_06_425584 647 36 ( ( -LRB- 10_1101-2021_01_06_425584 647 37 simulated simulate VBN 10_1101-2021_01_06_425584 647 38 diabetes diabetes NN 10_1101-2021_01_06_425584 647 39 ) ) -RRB- 10_1101-2021_01_06_425584 647 40 . . . 10_1101-2021_01_06_425584 648 1 Interacting interact VBG 10_1101-2021_01_06_425584 648 2 proteins protein NNS 10_1101-2021_01_06_425584 648 3 ( ( -LRB- 10_1101-2021_01_06_425584 648 4 < < XX 10_1101-2021_01_06_425584 648 5 0.9 0.9 CD 10_1101-2021_01_06_425584 648 6 891 891 CD 10_1101-2021_01_06_425584 648 7 confidence confidence NN 10_1101-2021_01_06_425584 648 8 ) ) -RRB- 10_1101-2021_01_06_425584 648 9 were be VBD 10_1101-2021_01_06_425584 648 10 retrieved retrieve VBN 10_1101-2021_01_06_425584 648 11 from from IN 10_1101-2021_01_06_425584 648 12 STRING STRING NNP 10_1101-2021_01_06_425584 648 13 Database Database NNP 10_1101-2021_01_06_425584 648 14 and and CC 10_1101-2021_01_06_425584 648 15 are be VBP 10_1101-2021_01_06_425584 648 16 shown show VBN 10_1101-2021_01_06_425584 648 17 as as IN 10_1101-2021_01_06_425584 648 18 gray gray JJ 10_1101-2021_01_06_425584 648 19 nodes node NNS 10_1101-2021_01_06_425584 648 20 . . . 10_1101-2021_01_06_425584 649 1 Abbreviations abbreviation NNS 10_1101-2021_01_06_425584 649 2 : : : 10_1101-2021_01_06_425584 649 3 892 892 CD 10_1101-2021_01_06_425584 649 4 NG NG NNP 10_1101-2021_01_06_425584 649 5 , , , 10_1101-2021_01_06_425584 649 6 normal normal JJ 10_1101-2021_01_06_425584 649 7 glucose glucose NN 10_1101-2021_01_06_425584 649 8 ; ; : 10_1101-2021_01_06_425584 649 9 HG HG NNP 10_1101-2021_01_06_425584 649 10 , , , 10_1101-2021_01_06_425584 649 11 high high JJ 10_1101-2021_01_06_425584 649 12 glucose glucose NN 10_1101-2021_01_06_425584 649 13 ; ; : 10_1101-2021_01_06_425584 649 14 HI hi UH 10_1101-2021_01_06_425584 649 15 , , , 10_1101-2021_01_06_425584 649 16 high high JJ 10_1101-2021_01_06_425584 649 17 insulin insulin NN 10_1101-2021_01_06_425584 649 18 . . . 10_1101-2021_01_06_425584 650 1 893 893 CD 10_1101-2021_01_06_425584 650 2 894 894 CD 10_1101-2021_01_06_425584 650 3 Figure Figure NNP 10_1101-2021_01_06_425584 650 4 7 7 CD 10_1101-2021_01_06_425584 650 5 . . . 10_1101-2021_01_06_425584 651 1 Increased increase VBN 10_1101-2021_01_06_425584 651 2 cellular cellular JJ 10_1101-2021_01_06_425584 651 3 binucleation binucleation NN 10_1101-2021_01_06_425584 651 4 by by IN 10_1101-2021_01_06_425584 651 5 simulated simulate VBN 10_1101-2021_01_06_425584 651 6 diabetes diabete NNS 10_1101-2021_01_06_425584 651 7 in in IN 10_1101-2021_01_06_425584 651 8 bovine bovine JJ 10_1101-2021_01_06_425584 651 9 coronary coronary JJ 10_1101-2021_01_06_425584 651 10 artery artery NN 10_1101-2021_01_06_425584 651 11 895 895 CD 10_1101-2021_01_06_425584 651 12 endothelial endothelial JJ 10_1101-2021_01_06_425584 651 13 cells cell NNS 10_1101-2021_01_06_425584 651 14 ( ( -LRB- 10_1101-2021_01_06_425584 651 15 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 651 16 ) ) -RRB- 10_1101-2021_01_06_425584 651 17 and and CC 10_1101-2021_01_06_425584 651 18 human human JJ 10_1101-2021_01_06_425584 651 19 coronary coronary JJ 10_1101-2021_01_06_425584 651 20 artery artery NN 10_1101-2021_01_06_425584 651 21 endothelial endothelial JJ 10_1101-2021_01_06_425584 651 22 cells cell NNS 10_1101-2021_01_06_425584 651 23 ( ( -LRB- 10_1101-2021_01_06_425584 651 24 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 651 25 ) ) -RRB- 10_1101-2021_01_06_425584 651 26 . . . 10_1101-2021_01_06_425584 652 1 ( ( -LRB- 10_1101-2021_01_06_425584 652 2 A a NN 10_1101-2021_01_06_425584 652 3 ) ) -RRB- 10_1101-2021_01_06_425584 652 4 896 896 CD 10_1101-2021_01_06_425584 652 5 Representative representative JJ 10_1101-2021_01_06_425584 652 6 immunofluorescence immunofluorescence NN 10_1101-2021_01_06_425584 652 7 micrographs micrograph NNS 10_1101-2021_01_06_425584 652 8 showing show VBG 10_1101-2021_01_06_425584 652 9 the the DT 10_1101-2021_01_06_425584 652 10 localization localization NN 10_1101-2021_01_06_425584 652 11 of of IN 10_1101-2021_01_06_425584 652 12 the the DT 10_1101-2021_01_06_425584 652 13 von von NNP 10_1101-2021_01_06_425584 652 14 - - HYPH 10_1101-2021_01_06_425584 652 15 Willebrand Willebrand NNP 10_1101-2021_01_06_425584 652 16 897 897 CD 10_1101-2021_01_06_425584 652 17 factor factor NN 10_1101-2021_01_06_425584 652 18 ( ( -LRB- 10_1101-2021_01_06_425584 652 19 vWf vWf NNS 10_1101-2021_01_06_425584 652 20 , , , 10_1101-2021_01_06_425584 652 21 1:400 1:400 CD 10_1101-2021_01_06_425584 652 22 , , , 10_1101-2021_01_06_425584 652 23 3 3 CD 10_1101-2021_01_06_425584 652 24 % % NN 10_1101-2021_01_06_425584 652 25 BSA BSA NNP 10_1101-2021_01_06_425584 652 26 in in IN 10_1101-2021_01_06_425584 652 27 PBS PBS NNP 10_1101-2021_01_06_425584 652 28 ) ) -RRB- 10_1101-2021_01_06_425584 652 29 in in IN 10_1101-2021_01_06_425584 652 30 fixed fix VBN 10_1101-2021_01_06_425584 652 31 and and CC 10_1101-2021_01_06_425584 652 32 permeabilized permeabilized JJ 10_1101-2021_01_06_425584 652 33 cells cell NNS 10_1101-2021_01_06_425584 652 34 . . . 10_1101-2021_01_06_425584 653 1 The the DT 10_1101-2021_01_06_425584 653 2 nuclei nucleus NNS 10_1101-2021_01_06_425584 653 3 were be VBD 10_1101-2021_01_06_425584 653 4 stained stain VBN 10_1101-2021_01_06_425584 653 5 898 898 CD 10_1101-2021_01_06_425584 653 6 using use VBG 10_1101-2021_01_06_425584 653 7 the the DT 10_1101-2021_01_06_425584 653 8 dye dye NN 10_1101-2021_01_06_425584 653 9 Hoechst Hoechst NNP 10_1101-2021_01_06_425584 653 10 33258 33258 CD 10_1101-2021_01_06_425584 653 11 ( ( -LRB- 10_1101-2021_01_06_425584 653 12 2 2 CD 10_1101-2021_01_06_425584 653 13 µg µg NN 10_1101-2021_01_06_425584 653 14 / / SYM 10_1101-2021_01_06_425584 653 15 ml ml NN 10_1101-2021_01_06_425584 653 16 in in IN 10_1101-2021_01_06_425584 653 17 HBSS HBSS NNP 10_1101-2021_01_06_425584 653 18 ) ) -RRB- 10_1101-2021_01_06_425584 653 19 . . . 10_1101-2021_01_06_425584 654 1 White white JJ 10_1101-2021_01_06_425584 654 2 arrows arrow NNS 10_1101-2021_01_06_425584 654 3 indicate indicate VBP 10_1101-2021_01_06_425584 654 4 binucleated binucleated JJ 10_1101-2021_01_06_425584 654 5 cells cell NNS 10_1101-2021_01_06_425584 654 6 . . . 10_1101-2021_01_06_425584 655 1 ( ( -LRB- 10_1101-2021_01_06_425584 655 2 B b NN 10_1101-2021_01_06_425584 655 3 ) ) -RRB- 10_1101-2021_01_06_425584 655 4 899 899 CD 10_1101-2021_01_06_425584 655 5 Quantification quantification NN 10_1101-2021_01_06_425584 655 6 of of IN 10_1101-2021_01_06_425584 655 7 binucleated binucleated JJ 10_1101-2021_01_06_425584 655 8 cells cell NNS 10_1101-2021_01_06_425584 655 9 in in IN 10_1101-2021_01_06_425584 655 10 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 655 11 and and CC 10_1101-2021_01_06_425584 655 12 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 655 13 under under IN 10_1101-2021_01_06_425584 655 14 simulated simulate VBN 10_1101-2021_01_06_425584 655 15 diabetes diabetes NN 10_1101-2021_01_06_425584 655 16 ( ( -LRB- 10_1101-2021_01_06_425584 655 17 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 655 18 ) ) -RRB- 10_1101-2021_01_06_425584 655 19 vs. vs. IN 10_1101-2021_01_06_425584 655 20 900 900 CD 10_1101-2021_01_06_425584 655 21 control control NN 10_1101-2021_01_06_425584 655 22 ( ( -LRB- 10_1101-2021_01_06_425584 655 23 NG NG NNP 10_1101-2021_01_06_425584 655 24 ) ) -RRB- 10_1101-2021_01_06_425584 655 25 group group NN 10_1101-2021_01_06_425584 655 26 . . . 10_1101-2021_01_06_425584 656 1 Fluorescence fluorescence NN 10_1101-2021_01_06_425584 656 2 images image NNS 10_1101-2021_01_06_425584 656 3 were be VBD 10_1101-2021_01_06_425584 656 4 taken take VBN 10_1101-2021_01_06_425584 656 5 in in RP 10_1101-2021_01_06_425584 656 6 at at RB 10_1101-2021_01_06_425584 656 7 least least RBS 10_1101-2021_01_06_425584 656 8 three three CD 10_1101-2021_01_06_425584 656 9 random random JJ 10_1101-2021_01_06_425584 656 10 fields field NNS 10_1101-2021_01_06_425584 656 11 per per IN 10_1101-2021_01_06_425584 656 12 condition condition NN 10_1101-2021_01_06_425584 656 13 901 901 CD 10_1101-2021_01_06_425584 656 14 using use VBG 10_1101-2021_01_06_425584 656 15 an an DT 10_1101-2021_01_06_425584 656 16 EVOS evos NN 10_1101-2021_01_06_425584 656 17 ® ® . 10_1101-2021_01_06_425584 656 18 FLoid floid NN 10_1101-2021_01_06_425584 656 19 ® ® : 10_1101-2021_01_06_425584 656 20 Cell Cell NNP 10_1101-2021_01_06_425584 656 21 Imaging Imaging NNP 10_1101-2021_01_06_425584 656 22 Station Station NNP 10_1101-2021_01_06_425584 656 23 with with IN 10_1101-2021_01_06_425584 656 24 a a DT 10_1101-2021_01_06_425584 656 25 fixed fix VBN 10_1101-2021_01_06_425584 656 26 20x 20x NNS 10_1101-2021_01_06_425584 656 27 air air NN 10_1101-2021_01_06_425584 656 28 objective objective NN 10_1101-2021_01_06_425584 656 29 . . . 10_1101-2021_01_06_425584 657 1 Image image NN 10_1101-2021_01_06_425584 657 2 analysis analysis NN 10_1101-2021_01_06_425584 657 3 was be VBD 10_1101-2021_01_06_425584 657 4 902 902 CD 10_1101-2021_01_06_425584 657 5 performed perform VBN 10_1101-2021_01_06_425584 657 6 by by IN 10_1101-2021_01_06_425584 657 7 ImageJ ImageJ NNP 10_1101-2021_01_06_425584 657 8 software software NN 10_1101-2021_01_06_425584 657 9 ( ( -LRB- 10_1101-2021_01_06_425584 657 10 version version NN 10_1101-2021_01_06_425584 657 11 2.0.0 2.0.0 CD 10_1101-2021_01_06_425584 657 12 ) ) -RRB- 10_1101-2021_01_06_425584 657 13 . . . 10_1101-2021_01_06_425584 658 1 Abbreviations abbreviation NNS 10_1101-2021_01_06_425584 658 2 : : : 10_1101-2021_01_06_425584 658 3 NG NG NNP 10_1101-2021_01_06_425584 658 4 , , , 10_1101-2021_01_06_425584 658 5 normal normal JJ 10_1101-2021_01_06_425584 658 6 glucose glucose NN 10_1101-2021_01_06_425584 658 7 ; ; : 10_1101-2021_01_06_425584 658 8 HG HG NNP 10_1101-2021_01_06_425584 658 9 , , , 10_1101-2021_01_06_425584 658 10 high high JJ 10_1101-2021_01_06_425584 658 11 903 903 CD 10_1101-2021_01_06_425584 658 12 glucose glucose NN 10_1101-2021_01_06_425584 658 13 ; ; : 10_1101-2021_01_06_425584 658 14 HI hi UH 10_1101-2021_01_06_425584 658 15 , , , 10_1101-2021_01_06_425584 658 16 high high JJ 10_1101-2021_01_06_425584 658 17 insulin insulin NN 10_1101-2021_01_06_425584 658 18 . . . 10_1101-2021_01_06_425584 659 1 904 904 CD 10_1101-2021_01_06_425584 659 2 905 905 CD 10_1101-2021_01_06_425584 659 3 Figure figure NN 10_1101-2021_01_06_425584 659 4 8 8 CD 10_1101-2021_01_06_425584 659 5 . . . 10_1101-2021_01_06_425584 660 1 Summary summary JJ 10_1101-2021_01_06_425584 660 2 illustration illustration NN 10_1101-2021_01_06_425584 660 3 of of IN 10_1101-2021_01_06_425584 660 4 study study NN 10_1101-2021_01_06_425584 660 5 findings finding NNS 10_1101-2021_01_06_425584 660 6 . . . 10_1101-2021_01_06_425584 661 1 Cellular cellular JJ 10_1101-2021_01_06_425584 661 2 structures structure NNS 10_1101-2021_01_06_425584 661 3 were be VBD 10_1101-2021_01_06_425584 661 4 created create VBN 10_1101-2021_01_06_425584 661 5 using use VBG 10_1101-2021_01_06_425584 661 6 906 906 CD 10_1101-2021_01_06_425584 661 7 Servier servier JJ 10_1101-2021_01_06_425584 661 8 Medical medical JJ 10_1101-2021_01_06_425584 661 9 Art art NN 10_1101-2021_01_06_425584 661 10 templates template NNS 10_1101-2021_01_06_425584 661 11 , , , 10_1101-2021_01_06_425584 661 12 which which WDT 10_1101-2021_01_06_425584 661 13 are be VBP 10_1101-2021_01_06_425584 661 14 licensed license VBN 10_1101-2021_01_06_425584 661 15 under under IN 10_1101-2021_01_06_425584 661 16 a a DT 10_1101-2021_01_06_425584 661 17 Creative Creative NNP 10_1101-2021_01_06_425584 661 18 Commons Commons NNP 10_1101-2021_01_06_425584 661 19 Attribution Attribution NNP 10_1101-2021_01_06_425584 661 20 3.0 3.0 CD 10_1101-2021_01_06_425584 661 21 907 907 CD 10_1101-2021_01_06_425584 661 22 Unported Unported NNP 10_1101-2021_01_06_425584 661 23 License License NNP 10_1101-2021_01_06_425584 661 24 ; ; : 10_1101-2021_01_06_425584 661 25 https://smart.servier.com https://smart.servier.com ADD 10_1101-2021_01_06_425584 661 26 . . . 10_1101-2021_01_06_425584 662 1 Chemical chemical JJ 10_1101-2021_01_06_425584 662 2 structures structure NNS 10_1101-2021_01_06_425584 662 3 were be VBD 10_1101-2021_01_06_425584 662 4 drawn draw VBN 10_1101-2021_01_06_425584 662 5 by by IN 10_1101-2021_01_06_425584 662 6 ChemDraw ChemDraw NNP 10_1101-2021_01_06_425584 662 7 908 908 CD 10_1101-2021_01_06_425584 662 8 Professional Professional NNP 10_1101-2021_01_06_425584 662 9 version version NN 10_1101-2021_01_06_425584 662 10 16.0.1.4 16.0.1.4 CD 10_1101-2021_01_06_425584 662 11 . . . 10_1101-2021_01_06_425584 663 1 909 909 CD 10_1101-2021_01_06_425584 663 2 910 910 CD 10_1101-2021_01_06_425584 663 3 911 911 CD 10_1101-2021_01_06_425584 663 4 912 912 CD 10_1101-2021_01_06_425584 663 5 .CC .CC : 10_1101-2021_01_06_425584 663 6 - - HYPH 10_1101-2021_01_06_425584 663 7 BY by IN 10_1101-2021_01_06_425584 663 8 - - HYPH 10_1101-2021_01_06_425584 663 9 NC NC NNP 10_1101-2021_01_06_425584 663 10 - - HYPH 10_1101-2021_01_06_425584 663 11 ND ND NNP 10_1101-2021_01_06_425584 663 12 4.0 4.0 CD 10_1101-2021_01_06_425584 663 13 International International NNP 10_1101-2021_01_06_425584 663 14 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 663 15 under under IN 10_1101-2021_01_06_425584 663 16 a a DT 10_1101-2021_01_06_425584 663 17 ( ( -LRB- 10_1101-2021_01_06_425584 663 18 which which WDT 10_1101-2021_01_06_425584 663 19 was be VBD 10_1101-2021_01_06_425584 663 20 not not RB 10_1101-2021_01_06_425584 663 21 certified certify VBN 10_1101-2021_01_06_425584 663 22 by by IN 10_1101-2021_01_06_425584 663 23 peer peer NN 10_1101-2021_01_06_425584 663 24 review review NN 10_1101-2021_01_06_425584 663 25 ) ) -RRB- 10_1101-2021_01_06_425584 663 26 is be VBZ 10_1101-2021_01_06_425584 663 27 the the DT 10_1101-2021_01_06_425584 663 28 author author NN 10_1101-2021_01_06_425584 663 29 / / SYM 10_1101-2021_01_06_425584 663 30 funder funder NN 10_1101-2021_01_06_425584 663 31 , , , 10_1101-2021_01_06_425584 663 32 who who WP 10_1101-2021_01_06_425584 663 33 has have VBZ 10_1101-2021_01_06_425584 663 34 granted grant VBN 10_1101-2021_01_06_425584 663 35 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 663 36 a a DT 10_1101-2021_01_06_425584 663 37 license license NN 10_1101-2021_01_06_425584 663 38 to to TO 10_1101-2021_01_06_425584 663 39 display display VB 10_1101-2021_01_06_425584 663 40 the the DT 10_1101-2021_01_06_425584 663 41 preprint preprint NN 10_1101-2021_01_06_425584 663 42 in in IN 10_1101-2021_01_06_425584 663 43 perpetuity perpetuity NN 10_1101-2021_01_06_425584 663 44 . . . 10_1101-2021_01_06_425584 664 1 It -PRON- PRP 10_1101-2021_01_06_425584 664 2 is be VBZ 10_1101-2021_01_06_425584 664 3 made make VBN 10_1101-2021_01_06_425584 664 4 The the DT 10_1101-2021_01_06_425584 664 5 copyright copyright NN 10_1101-2021_01_06_425584 664 6 holder holder NN 10_1101-2021_01_06_425584 664 7 for for IN 10_1101-2021_01_06_425584 664 8 this this DT 10_1101-2021_01_06_425584 664 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 664 10 version version NN 10_1101-2021_01_06_425584 664 11 posted post VBD 10_1101-2021_01_06_425584 664 12 January January NNP 10_1101-2021_01_06_425584 664 13 8 8 CD 10_1101-2021_01_06_425584 664 14 , , , 10_1101-2021_01_06_425584 664 15 2021 2021 CD 10_1101-2021_01_06_425584 664 16 . . . 10_1101-2021_01_06_425584 664 17 ; ; : 10_1101-2021_01_06_425584 664 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 664 19 : : : 10_1101-2021_01_06_425584 664 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 664 21 preprint preprint NN 10_1101-2021_01_06_425584 664 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 664 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ RB 10_1101-2021_01_06_425584 664 24 30 30 CD 10_1101-2021_01_06_425584 664 25 Supporting support VBG 10_1101-2021_01_06_425584 664 26 information information NN 10_1101-2021_01_06_425584 664 27 913 913 CD 10_1101-2021_01_06_425584 664 28 914 914 CD 10_1101-2021_01_06_425584 664 29 Table table NN 10_1101-2021_01_06_425584 664 30 S1 S1 NNS 10_1101-2021_01_06_425584 664 31 . . . 10_1101-2021_01_06_425584 665 1 List list NN 10_1101-2021_01_06_425584 665 2 of of IN 10_1101-2021_01_06_425584 665 3 all all PDT 10_1101-2021_01_06_425584 665 4 the the DT 10_1101-2021_01_06_425584 665 5 putatively putatively RB 10_1101-2021_01_06_425584 665 6 annotated annotate VBN 10_1101-2021_01_06_425584 665 7 metabolites metabolite NNS 10_1101-2021_01_06_425584 665 8 by by IN 10_1101-2021_01_06_425584 665 9 MS2 MS2 NNP 10_1101-2021_01_06_425584 665 10 spectral spectral JJ 10_1101-2021_01_06_425584 665 11 matching matching NN 10_1101-2021_01_06_425584 665 12 against against IN 10_1101-2021_01_06_425584 665 13 GNPS GNPS NNP 10_1101-2021_01_06_425584 665 14 915 915 CD 10_1101-2021_01_06_425584 665 15 public public JJ 10_1101-2021_01_06_425584 665 16 spectral spectral JJ 10_1101-2021_01_06_425584 665 17 libraries library NNS 10_1101-2021_01_06_425584 665 18 . . . 10_1101-2021_01_06_425584 666 1 916 916 CD 10_1101-2021_01_06_425584 666 2 917 917 CD 10_1101-2021_01_06_425584 666 3 Table table NN 10_1101-2021_01_06_425584 666 4 S2 s2 NN 10_1101-2021_01_06_425584 666 5 . . . 10_1101-2021_01_06_425584 667 1 List list NN 10_1101-2021_01_06_425584 667 2 of of IN 10_1101-2021_01_06_425584 667 3 putatively putatively RB 10_1101-2021_01_06_425584 667 4 annotated annotate VBN 10_1101-2021_01_06_425584 667 5 ( ( -LRB- 10_1101-2021_01_06_425584 667 6 MS2 MS2 NNP 10_1101-2021_01_06_425584 667 7 spectral spectral JJ 10_1101-2021_01_06_425584 667 8 matching matching NN 10_1101-2021_01_06_425584 667 9 ) ) -RRB- 10_1101-2021_01_06_425584 667 10 metabolites metabolite NNS 10_1101-2021_01_06_425584 667 11 modulated modulate VBN 10_1101-2021_01_06_425584 667 12 by by IN 10_1101-2021_01_06_425584 667 13 918 918 CD 10_1101-2021_01_06_425584 667 14 simulated simulated JJ 10_1101-2021_01_06_425584 667 15 diabetes diabete NNS 10_1101-2021_01_06_425584 667 16 . . . 10_1101-2021_01_06_425584 668 1 919 919 CD 10_1101-2021_01_06_425584 668 2 920 920 CD 10_1101-2021_01_06_425584 668 3 Table table NN 10_1101-2021_01_06_425584 668 4 S3 S3 NNP 10_1101-2021_01_06_425584 668 5 . . . 10_1101-2021_01_06_425584 669 1 List list NN 10_1101-2021_01_06_425584 669 2 of of IN 10_1101-2021_01_06_425584 669 3 all all DT 10_1101-2021_01_06_425584 669 4 detected detect VBN 10_1101-2021_01_06_425584 669 5 peptides peptide NNS 10_1101-2021_01_06_425584 669 6 by by IN 10_1101-2021_01_06_425584 669 7 ProteinPilot ProteinPilot NNP 10_1101-2021_01_06_425584 669 8 Software Software NNP 10_1101-2021_01_06_425584 669 9 using use VBG 10_1101-2021_01_06_425584 669 10 the the DT 10_1101-2021_01_06_425584 669 11 metabolomics metabolomic NNS 10_1101-2021_01_06_425584 669 12 datasets dataset NNS 10_1101-2021_01_06_425584 669 13 . . . 10_1101-2021_01_06_425584 670 1 921 921 CD 10_1101-2021_01_06_425584 670 2 922 922 CD 10_1101-2021_01_06_425584 670 3 Table table NN 10_1101-2021_01_06_425584 670 4 S4 s4 NN 10_1101-2021_01_06_425584 670 5 Putative Putative NNP 10_1101-2021_01_06_425584 670 6 annotated annotate VBD 10_1101-2021_01_06_425584 670 7 proline proline NN 10_1101-2021_01_06_425584 670 8 - - HYPH 10_1101-2021_01_06_425584 670 9 peptides peptide NNS 10_1101-2021_01_06_425584 670 10 altered alter VBN 10_1101-2021_01_06_425584 670 11 by by IN 10_1101-2021_01_06_425584 670 12 simulated simulated JJ 10_1101-2021_01_06_425584 670 13 diabetes diabete NNS 10_1101-2021_01_06_425584 670 14 in in IN 10_1101-2021_01_06_425584 670 15 Bovine Bovine NNP 10_1101-2021_01_06_425584 670 16 Coronary Coronary NNP 10_1101-2021_01_06_425584 670 17 923 923 CD 10_1101-2021_01_06_425584 670 18 Artery Artery NNP 10_1101-2021_01_06_425584 670 19 Endothelial Endothelial NNP 10_1101-2021_01_06_425584 670 20 Cells Cells NNPS 10_1101-2021_01_06_425584 670 21 by by IN 10_1101-2021_01_06_425584 670 22 ProteinPilot ProteinPilot NNP 10_1101-2021_01_06_425584 670 23 Software Software NNP 10_1101-2021_01_06_425584 670 24 and and CC 10_1101-2021_01_06_425584 670 25 manual manual JJ 10_1101-2021_01_06_425584 670 26 inspection inspection NN 10_1101-2021_01_06_425584 670 27 . . . 10_1101-2021_01_06_425584 671 1 924 924 CD 10_1101-2021_01_06_425584 671 2 925 925 CD 10_1101-2021_01_06_425584 671 3 Table table NN 10_1101-2021_01_06_425584 671 4 S5 s5 NN 10_1101-2021_01_06_425584 671 5 . . . 10_1101-2021_01_06_425584 672 1 List list NN 10_1101-2021_01_06_425584 672 2 of of IN 10_1101-2021_01_06_425584 672 3 the the DT 10_1101-2021_01_06_425584 672 4 detected detect VBN 10_1101-2021_01_06_425584 672 5 peptides peptide NNS 10_1101-2021_01_06_425584 672 6 and and CC 10_1101-2021_01_06_425584 672 7 proteins protein NNS 10_1101-2021_01_06_425584 672 8 in in IN 10_1101-2021_01_06_425584 672 9 all all DT 10_1101-2021_01_06_425584 672 10 conditions condition NNS 10_1101-2021_01_06_425584 672 11 for for IN 10_1101-2021_01_06_425584 672 12 SWATH SWATH NNP 10_1101-2021_01_06_425584 672 13 - - HYPH 10_1101-2021_01_06_425584 672 14 based base VBN 10_1101-2021_01_06_425584 672 15 926 926 CD 10_1101-2021_01_06_425584 672 16 quantification quantification NN 10_1101-2021_01_06_425584 672 17 . . . 10_1101-2021_01_06_425584 673 1 927 927 CD 10_1101-2021_01_06_425584 673 2 928 928 CD 10_1101-2021_01_06_425584 673 3 Figure figure NN 10_1101-2021_01_06_425584 673 4 S1 S1 NNS 10_1101-2021_01_06_425584 673 5 . . . 10_1101-2021_01_06_425584 674 1 Proteomics Proteomics NNP 10_1101-2021_01_06_425584 674 2 data data NN 10_1101-2021_01_06_425584 674 3 normalization normalization NN 10_1101-2021_01_06_425584 674 4 results result NNS 10_1101-2021_01_06_425584 674 5 using use VBG 10_1101-2021_01_06_425584 674 6 NormalyzerDE NormalyzerDE NNP 10_1101-2021_01_06_425584 674 7 . . . 10_1101-2021_01_06_425584 675 1 ( ( -LRB- 10_1101-2021_01_06_425584 675 2 A a DT 10_1101-2021_01_06_425584 675 3 ) ) -RRB- 10_1101-2021_01_06_425584 675 4 Total total JJ 10_1101-2021_01_06_425584 675 5 intensity intensity NN 10_1101-2021_01_06_425584 675 6 of of IN 10_1101-2021_01_06_425584 675 7 raw raw JJ 10_1101-2021_01_06_425584 675 8 929 929 CD 10_1101-2021_01_06_425584 675 9 data datum NNS 10_1101-2021_01_06_425584 675 10 before before IN 10_1101-2021_01_06_425584 675 11 normalization normalization NN 10_1101-2021_01_06_425584 675 12 . . . 10_1101-2021_01_06_425584 676 1 ( ( -LRB- 10_1101-2021_01_06_425584 676 2 B b NN 10_1101-2021_01_06_425584 676 3 ) ) -RRB- 10_1101-2021_01_06_425584 676 4 Quantitative quantitative JJ 10_1101-2021_01_06_425584 676 5 parameters parameter NNS 10_1101-2021_01_06_425584 676 6 of of IN 10_1101-2021_01_06_425584 676 7 normalization normalization NN 10_1101-2021_01_06_425584 676 8 algorithms algorithm NNS 10_1101-2021_01_06_425584 676 9 ( ( -LRB- 10_1101-2021_01_06_425584 676 10 pooled pool VBN 10_1101-2021_01_06_425584 676 11 930 930 CD 10_1101-2021_01_06_425584 676 12 intragroup intragroup JJ 10_1101-2021_01_06_425584 676 13 coefficient coefficient NN 10_1101-2021_01_06_425584 676 14 of of IN 10_1101-2021_01_06_425584 676 15 variation variation NN 10_1101-2021_01_06_425584 676 16 [ [ -LRB- 10_1101-2021_01_06_425584 676 17 PCV PCV NNP 10_1101-2021_01_06_425584 676 18 ] ] -RRB- 10_1101-2021_01_06_425584 676 19 , , , 10_1101-2021_01_06_425584 676 20 median median JJ 10_1101-2021_01_06_425584 676 21 absolute absolute JJ 10_1101-2021_01_06_425584 676 22 deviation deviation NN 10_1101-2021_01_06_425584 676 23 [ [ -LRB- 10_1101-2021_01_06_425584 676 24 PMAD PMAD NNP 10_1101-2021_01_06_425584 676 25 ] ] -RRB- 10_1101-2021_01_06_425584 676 26 , , , 10_1101-2021_01_06_425584 676 27 estimate estimate NN 10_1101-2021_01_06_425584 676 28 of of IN 10_1101-2021_01_06_425584 676 29 variance variance NN 10_1101-2021_01_06_425584 676 30 931 931 CD 10_1101-2021_01_06_425584 676 31 [ [ -LRB- 10_1101-2021_01_06_425584 676 32 PEV PEV NNP 10_1101-2021_01_06_425584 676 33 ] ] -RRB- 10_1101-2021_01_06_425584 676 34 ) ) -RRB- 10_1101-2021_01_06_425584 676 35 . . . 10_1101-2021_01_06_425584 677 1 Qualitative qualitative JJ 10_1101-2021_01_06_425584 677 2 parameters parameter NNS 10_1101-2021_01_06_425584 677 3 of of IN 10_1101-2021_01_06_425584 677 4 normalization normalization NN 10_1101-2021_01_06_425584 677 5 algorithms algorithm NNS 10_1101-2021_01_06_425584 677 6 ; ; : 10_1101-2021_01_06_425584 677 7 ( ( -LRB- 10_1101-2021_01_06_425584 677 8 C C NNP 10_1101-2021_01_06_425584 677 9 ) ) -RRB- 10_1101-2021_01_06_425584 677 10 Box Box NNP 10_1101-2021_01_06_425584 677 11 plots plot NNS 10_1101-2021_01_06_425584 677 12 ( ( -LRB- 10_1101-2021_01_06_425584 677 13 D D NNP 10_1101-2021_01_06_425584 677 14 ) ) -RRB- 10_1101-2021_01_06_425584 677 15 MA MA NNP 10_1101-2021_01_06_425584 677 16 plots plot NNS 10_1101-2021_01_06_425584 677 17 , , , 10_1101-2021_01_06_425584 677 18 and and CC 10_1101-2021_01_06_425584 677 19 ( ( -LRB- 10_1101-2021_01_06_425584 677 20 E e NN 10_1101-2021_01_06_425584 677 21 ) ) -RRB- 10_1101-2021_01_06_425584 677 22 932 932 CD 10_1101-2021_01_06_425584 677 23 Density density NN 10_1101-2021_01_06_425584 677 24 plots plot NNS 10_1101-2021_01_06_425584 677 25 . . . 10_1101-2021_01_06_425584 678 1 933 933 CD 10_1101-2021_01_06_425584 678 2 934 934 CD 10_1101-2021_01_06_425584 678 3 Figure figure NN 10_1101-2021_01_06_425584 678 4 S2 s2 NN 10_1101-2021_01_06_425584 678 5 . . . 10_1101-2021_01_06_425584 679 1 Cellular cellular JJ 10_1101-2021_01_06_425584 679 2 confluence confluence NN 10_1101-2021_01_06_425584 679 3 in in IN 10_1101-2021_01_06_425584 679 4 control control NN 10_1101-2021_01_06_425584 679 5 and and CC 10_1101-2021_01_06_425584 679 6 experimental experimental JJ 10_1101-2021_01_06_425584 679 7 group group NN 10_1101-2021_01_06_425584 679 8 . . . 10_1101-2021_01_06_425584 680 1 Representative representative NN 10_1101-2021_01_06_425584 680 2 935 935 CD 10_1101-2021_01_06_425584 680 3 micrographs micrograph NNS 10_1101-2021_01_06_425584 680 4 of of IN 10_1101-2021_01_06_425584 680 5 Bovine Bovine NNP 10_1101-2021_01_06_425584 680 6 Coronary Coronary NNP 10_1101-2021_01_06_425584 680 7 Artery Artery NNP 10_1101-2021_01_06_425584 680 8 Endothelial Endothelial NNP 10_1101-2021_01_06_425584 680 9 Cells Cells NNPS 10_1101-2021_01_06_425584 680 10 ( ( -LRB- 10_1101-2021_01_06_425584 680 11 BCAEC BCAEC NNP 10_1101-2021_01_06_425584 680 12 ) ) -RRB- 10_1101-2021_01_06_425584 680 13 cultured culture VBD 10_1101-2021_01_06_425584 680 14 for for IN 10_1101-2021_01_06_425584 680 15 9 9 CD 10_1101-2021_01_06_425584 680 16 days day NNS 10_1101-2021_01_06_425584 680 17 with with IN 10_1101-2021_01_06_425584 680 18 5.5 5.5 CD 10_1101-2021_01_06_425584 680 19 936 936 CD 10_1101-2021_01_06_425584 680 20 mmol mmol NN 10_1101-2021_01_06_425584 680 21 / / SYM 10_1101-2021_01_06_425584 680 22 L l NN 10_1101-2021_01_06_425584 680 23 glucose glucose NN 10_1101-2021_01_06_425584 680 24 ( ( -LRB- 10_1101-2021_01_06_425584 680 25 control control NNP 10_1101-2021_01_06_425584 680 26 group group NN 10_1101-2021_01_06_425584 680 27 ) ) -RRB- 10_1101-2021_01_06_425584 680 28 and and CC 10_1101-2021_01_06_425584 680 29 20 20 CD 10_1101-2021_01_06_425584 680 30 mmol mmol NN 10_1101-2021_01_06_425584 680 31 / / SYM 10_1101-2021_01_06_425584 680 32 L L NNP 10_1101-2021_01_06_425584 680 33 glucose+100 glucose+100 NNP 10_1101-2021_01_06_425584 680 34 nmol nmol NNP 10_1101-2021_01_06_425584 680 35 / / SYM 10_1101-2021_01_06_425584 680 36 L L NNP 10_1101-2021_01_06_425584 680 37 insulin insulin NN 10_1101-2021_01_06_425584 680 38 ( ( -LRB- 10_1101-2021_01_06_425584 680 39 simulated simulate VBN 10_1101-2021_01_06_425584 680 40 diabetes diabetes NN 10_1101-2021_01_06_425584 680 41 937 937 CD 10_1101-2021_01_06_425584 680 42 or or CC 10_1101-2021_01_06_425584 680 43 experimental experimental JJ 10_1101-2021_01_06_425584 680 44 group group NN 10_1101-2021_01_06_425584 680 45 ) ) -RRB- 10_1101-2021_01_06_425584 680 46 . . . 10_1101-2021_01_06_425584 681 1 Images image NNS 10_1101-2021_01_06_425584 681 2 were be VBD 10_1101-2021_01_06_425584 681 3 taken take VBN 10_1101-2021_01_06_425584 681 4 using use VBG 10_1101-2021_01_06_425584 681 5 an an DT 10_1101-2021_01_06_425584 681 6 EVOS evos NN 10_1101-2021_01_06_425584 681 7 ® ® . 10_1101-2021_01_06_425584 681 8 FLoid floid NN 10_1101-2021_01_06_425584 681 9 ® ® : 10_1101-2021_01_06_425584 681 10 Cell Cell NNP 10_1101-2021_01_06_425584 681 11 Imaging Imaging NNP 10_1101-2021_01_06_425584 681 12 Station Station NNP 10_1101-2021_01_06_425584 681 13 with with IN 10_1101-2021_01_06_425584 681 14 a a DT 10_1101-2021_01_06_425584 681 15 938 938 CD 10_1101-2021_01_06_425584 681 16 fixed fix VBN 10_1101-2021_01_06_425584 681 17 20x 20x NNS 10_1101-2021_01_06_425584 681 18 air air NN 10_1101-2021_01_06_425584 681 19 objective objective NN 10_1101-2021_01_06_425584 681 20 . . . 10_1101-2021_01_06_425584 682 1 Abbreviations abbreviation NNS 10_1101-2021_01_06_425584 682 2 : : : 10_1101-2021_01_06_425584 682 3 NG NG NNP 10_1101-2021_01_06_425584 682 4 , , , 10_1101-2021_01_06_425584 682 5 normal normal JJ 10_1101-2021_01_06_425584 682 6 glucose glucose NN 10_1101-2021_01_06_425584 682 7 ; ; : 10_1101-2021_01_06_425584 682 8 HG HG NNP 10_1101-2021_01_06_425584 682 9 , , , 10_1101-2021_01_06_425584 682 10 high high JJ 10_1101-2021_01_06_425584 682 11 glucose glucose NN 10_1101-2021_01_06_425584 682 12 ; ; : 10_1101-2021_01_06_425584 682 13 HI hi UH 10_1101-2021_01_06_425584 682 14 , , , 10_1101-2021_01_06_425584 682 15 high high JJ 10_1101-2021_01_06_425584 682 16 insulin insulin NN 10_1101-2021_01_06_425584 682 17 . . . 10_1101-2021_01_06_425584 683 1 939 939 CD 10_1101-2021_01_06_425584 683 2 940 940 CD 10_1101-2021_01_06_425584 683 3 941 941 CD 10_1101-2021_01_06_425584 683 4 942 942 CD 10_1101-2021_01_06_425584 683 5 .CC .CC : 10_1101-2021_01_06_425584 683 6 - - HYPH 10_1101-2021_01_06_425584 683 7 BY by IN 10_1101-2021_01_06_425584 683 8 - - HYPH 10_1101-2021_01_06_425584 683 9 NC NC NNP 10_1101-2021_01_06_425584 683 10 - - HYPH 10_1101-2021_01_06_425584 683 11 ND ND NNP 10_1101-2021_01_06_425584 683 12 4.0 4.0 CD 10_1101-2021_01_06_425584 683 13 International International NNP 10_1101-2021_01_06_425584 683 14 licenseavailable licenseavailable NN 10_1101-2021_01_06_425584 683 15 under under IN 10_1101-2021_01_06_425584 683 16 a a DT 10_1101-2021_01_06_425584 683 17 ( ( -LRB- 10_1101-2021_01_06_425584 683 18 which which WDT 10_1101-2021_01_06_425584 683 19 was be VBD 10_1101-2021_01_06_425584 683 20 not not RB 10_1101-2021_01_06_425584 683 21 certified certify VBN 10_1101-2021_01_06_425584 683 22 by by IN 10_1101-2021_01_06_425584 683 23 peer peer NN 10_1101-2021_01_06_425584 683 24 review review NN 10_1101-2021_01_06_425584 683 25 ) ) -RRB- 10_1101-2021_01_06_425584 683 26 is be VBZ 10_1101-2021_01_06_425584 683 27 the the DT 10_1101-2021_01_06_425584 683 28 author author NN 10_1101-2021_01_06_425584 683 29 / / SYM 10_1101-2021_01_06_425584 683 30 funder funder NN 10_1101-2021_01_06_425584 683 31 , , , 10_1101-2021_01_06_425584 683 32 who who WP 10_1101-2021_01_06_425584 683 33 has have VBZ 10_1101-2021_01_06_425584 683 34 granted grant VBN 10_1101-2021_01_06_425584 683 35 bioRxiv biorxiv IN 10_1101-2021_01_06_425584 683 36 a a DT 10_1101-2021_01_06_425584 683 37 license license NN 10_1101-2021_01_06_425584 683 38 to to TO 10_1101-2021_01_06_425584 683 39 display display VB 10_1101-2021_01_06_425584 683 40 the the DT 10_1101-2021_01_06_425584 683 41 preprint preprint NN 10_1101-2021_01_06_425584 683 42 in in IN 10_1101-2021_01_06_425584 683 43 perpetuity perpetuity NN 10_1101-2021_01_06_425584 683 44 . . . 10_1101-2021_01_06_425584 684 1 It -PRON- PRP 10_1101-2021_01_06_425584 684 2 is be VBZ 10_1101-2021_01_06_425584 684 3 made make VBN 10_1101-2021_01_06_425584 684 4 The the DT 10_1101-2021_01_06_425584 684 5 copyright copyright NN 10_1101-2021_01_06_425584 684 6 holder holder NN 10_1101-2021_01_06_425584 684 7 for for IN 10_1101-2021_01_06_425584 684 8 this this DT 10_1101-2021_01_06_425584 684 9 preprintthis preprintthis NN 10_1101-2021_01_06_425584 684 10 version version NN 10_1101-2021_01_06_425584 684 11 posted post VBD 10_1101-2021_01_06_425584 684 12 January January NNP 10_1101-2021_01_06_425584 684 13 8 8 CD 10_1101-2021_01_06_425584 684 14 , , , 10_1101-2021_01_06_425584 684 15 2021 2021 CD 10_1101-2021_01_06_425584 684 16 . . . 10_1101-2021_01_06_425584 684 17 ; ; : 10_1101-2021_01_06_425584 684 18 https://doi.org/10.1101/2021.01.06.425584doi https://doi.org/10.1101/2021.01.06.425584doi DT 10_1101-2021_01_06_425584 684 19 : : : 10_1101-2021_01_06_425584 684 20 bioRxiv biorxiv VB 10_1101-2021_01_06_425584 684 21 preprint preprint NN 10_1101-2021_01_06_425584 684 22 https://doi.org/10.1101/2021.01.06.425584 https://doi.org/10.1101/2021.01.06.425584 UH 10_1101-2021_01_06_425584 684 23 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_06_425584 684 24 Metabolites Metabolites NNP 10_1101-2021_01_06_425584 684 25 DDA DDA NNP 10_1101-2021_01_06_425584 684 26 Omics Omics NNPS 10_1101-2021_01_06_425584 684 27 Integration Integration NNP 10_1101-2021_01_06_425584 684 28 GO GO NNP 10_1101-2021_01_06_425584 684 29 analysis analysis NN 10_1101-2021_01_06_425584 684 30 ProteomeXchange ProteomeXchange NNP 10_1101-2021_01_06_425584 684 31 PXD013643 PXD013643 NNP 10_1101-2021_01_06_425584 684 32 ` ` '' 10_1101-2021_01_06_425584 684 33 ` ` '' 10_1101-2021_01_06_425584 684 34 SWATH SWATH NNP 10_1101-2021_01_06_425584 684 35 - - HYPH 10_1101-2021_01_06_425584 684 36 based base VBN 10_1101-2021_01_06_425584 684 37 Proteomics proteomic NNS 10_1101-2021_01_06_425584 684 38 ` ` '' 10_1101-2021_01_06_425584 684 39 ` ` '' 10_1101-2021_01_06_425584 684 40 Untargeted Untargeted NNP 10_1101-2021_01_06_425584 684 41 Metabolomics Metabolomics NNPS 10_1101-2021_01_06_425584 684 42 MeOH MeOH NNP 10_1101-2021_01_06_425584 684 43 / / SYM 10_1101-2021_01_06_425584 684 44 EtOH EtOH NNP 10_1101-2021_01_06_425584 684 45 ( ( -LRB- 10_1101-2021_01_06_425584 684 46 50:50 50:50 CD 10_1101-2021_01_06_425584 684 47 , , , 10_1101-2021_01_06_425584 684 48 v v NN 10_1101-2021_01_06_425584 684 49 : : : 10_1101-2021_01_06_425584 684 50 v v LS 10_1101-2021_01_06_425584 684 51 ) ) -RRB- 10_1101-2021_01_06_425584 684 52 0 0 CD 10_1101-2021_01_06_425584 684 53 1 1 CD 10_1101-2021_01_06_425584 684 54 2 2 CD 10_1101-2021_01_06_425584 684 55 3 3 CD 10_1101-2021_01_06_425584 684 56 4 4 CD 10_1101-2021_01_06_425584 684 57 5 5 CD 10_1101-2021_01_06_425584 684 58 6 6 CD 10_1101-2021_01_06_425584 684 59 7 7 CD 10_1101-2021_01_06_425584 684 60 8 8 CD 10_1101-2021_01_06_425584 684 61 9 9 CD 10_1101-2021_01_06_425584 684 62 10 10 CD 10_1101-2021_01_06_425584 684 63 11 11 CD 10_1101-2021_01_06_425584 684 64 12 12 CD 10_1101-2021_01_06_425584 684 65 Insulin Insulin NNP 10_1101-2021_01_06_425584 684 66 100 100 CD 10_1101-2021_01_06_425584 684 67 nmol nmol JJ 10_1101-2021_01_06_425584 684 68 / / SYM 10_1101-2021_01_06_425584 684 69 L L NNP 10_1101-2021_01_06_425584 684 70 Glucose Glucose NNP 10_1101-2021_01_06_425584 684 71 20 20 CD 10_1101-2021_01_06_425584 684 72 mmol mmol NN 10_1101-2021_01_06_425584 684 73 / / SYM 10_1101-2021_01_06_425584 684 74 L L NNP 10_1101-2021_01_06_425584 684 75 Days Days NNPS 10_1101-2021_01_06_425584 684 76 Glucose Glucose NNP 10_1101-2021_01_06_425584 684 77 5.5 5.5 CD 10_1101-2021_01_06_425584 684 78 mmol mmol NN 10_1101-2021_01_06_425584 684 79 / / SYM 10_1101-2021_01_06_425584 684 80 L L NNP 10_1101-2021_01_06_425584 684 81 Control Control NNP 10_1101-2021_01_06_425584 684 82 Substructure substructure NN 10_1101-2021_01_06_425584 684 83 annotation annotation NN 10_1101-2021_01_06_425584 684 84 Ry Ry NNP 10_1101-2021_01_06_425584 684 85 Metabolite metabolite JJ 10_1101-2021_01_06_425584 684 86 annotation annotation NN 10_1101-2021_01_06_425584 684 87 COOH COOH NNP 10_1101-2021_01_06_425584 684 88 ` ` '' 10_1101-2021_01_06_425584 684 89 ` ` '' 10_1101-2021_01_06_425584 684 90 m m NN 10_1101-2021_01_06_425584 684 91 / / SYM 10_1101-2021_01_06_425584 684 92 z z NNP 10_1101-2021_01_06_425584 684 93 m m NNP 10_1101-2021_01_06_425584 684 94 / / SYM 10_1101-2021_01_06_425584 684 95 z z NNP 10_1101-2021_01_06_425584 684 96 RT RT NNP 10_1101-2021_01_06_425584 684 97 In in IN 10_1101-2021_01_06_425584 684 98 te te NNP 10_1101-2021_01_06_425584 684 99 ns ns IN 10_1101-2021_01_06_425584 684 100 it -PRON- PRP 10_1101-2021_01_06_425584 684 101 y y VBZ 10_1101-2021_01_06_425584 684 102 In in IN 10_1101-2021_01_06_425584 684 103 te te NNP 10_1101-2021_01_06_425584 684 104 ns ns IN 10_1101-2021_01_06_425584 684 105 it -PRON- PRP 10_1101-2021_01_06_425584 684 106 y y VBZ 10_1101-2021_01_06_425584 684 107 In in IN 10_1101-2021_01_06_425584 684 108 te te NNP 10_1101-2021_01_06_425584 684 109 ns ns IN 10_1101-2021_01_06_425584 684 110 it -PRON- PRP 10_1101-2021_01_06_425584 684 111 y y VBZ 10_1101-2021_01_06_425584 684 112 MS1 MS1 NNP 10_1101-2021_01_06_425584 684 113 MS2 MS2 NNP 10_1101-2021_01_06_425584 684 114 A A NNP 10_1101-2021_01_06_425584 684 115 B B NNP 10_1101-2021_01_06_425584 684 116 SC SC NNP 10_1101-2021_01_06_425584 684 117 IEX IEX NNP 10_1101-2021_01_06_425584 684 118 Trip Trip NNP 10_1101-2021_01_06_425584 684 119 le le VBP 10_1101-2021_01_06_425584 684 120 TO to IN 10_1101-2021_01_06_425584 684 121 F F NNP 10_1101-2021_01_06_425584 684 122 5 5 CD 10_1101-2021_01_06_425584 684 123 6 6 CD 10_1101-2021_01_06_425584 684 124 0 0 CD 10_1101-2021_01_06_425584 684 125 0 0 CD 10_1101-2021_01_06_425584 684 126 LC LC NNP 10_1101-2021_01_06_425584 684 127 - - HYPH 10_1101-2021_01_06_425584 684 128 MS MS NNP 10_1101-2021_01_06_425584 684 129 / / SYM 10_1101-2021_01_06_425584 684 130 MS MS NNP 10_1101-2021_01_06_425584 684 131 Triple Triple NNP 10_1101-2021_01_06_425584 684 132 ® ® NNPS 10_1101-2021_01_06_425584 684 133 TOF TOF NNP 10_1101-2021_01_06_425584 684 134 5600 5600 CD 10_1101-2021_01_06_425584 684 135 + + CC 10_1101-2021_01_06_425584 684 136 A a DT 10_1101-2021_01_06_425584 684 137 957 957 CD 10_1101-2021_01_06_425584 684 138 ( ( -LRB- 10_1101-2021_01_06_425584 684 139 17.18 17.18 CD 10_1101-2021_01_06_425584 684 140 % % NN 10_1101-2021_01_06_425584 684 141 ) ) -RRB- 10_1101-2021_01_06_425584 684 142 Total total JJ 10_1101-2021_01_06_425584 684 143 features feature NNS 10_1101-2021_01_06_425584 684 144 detected detect VBD 10_1101-2021_01_06_425584 684 145 : : : 10_1101-2021_01_06_425584 684 146 5571 5571 CD 10_1101-2021_01_06_425584 684 147 2194 2194 CD 10_1101-2021_01_06_425584 684 148 ( ( -LRB- 10_1101-2021_01_06_425584 684 149 39.96 39.96 CD 10_1101-2021_01_06_425584 684 150 % % NN 10_1101-2021_01_06_425584 684 151 ) ) -RRB- 10_1101-2021_01_06_425584 684 152 2420 2420 CD 10_1101-2021_01_06_425584 684 153 ( ( -LRB- 10_1101-2021_01_06_425584 684 154 43.44 43.44 CD 10_1101-2021_01_06_425584 684 155 % % NN 10_1101-2021_01_06_425584 684 156 ) ) -RRB- 10_1101-2021_01_06_425584 684 157 n=82n=140 n=82n=140 VBP 10_1101-2021_01_06_425584 684 158 B b NN 10_1101-2021_01_06_425584 684 159 C c NN 10_1101-2021_01_06_425584 684 160 D d NN 10_1101-2021_01_06_425584 684 161 N n CD 10_1101-2021_01_06_425584 684 162 orm orm NN 10_1101-2021_01_06_425584 684 163 alized alize VBN 10_1101-2021_01_06_425584 684 164 m m NN 10_1101-2021_01_06_425584 684 165 etabolite etabolite NN 10_1101-2021_01_06_425584 684 166 abundance abundance NN 10_1101-2021_01_06_425584 684 167 PC1 PC1 NNP 10_1101-2021_01_06_425584 684 168 P P NNP 10_1101-2021_01_06_425584 684 169 C c NN 10_1101-2021_01_06_425584 684 170 2 2 CD 10_1101-2021_01_06_425584 684 171 NG NG NNP 10_1101-2021_01_06_425584 684 172 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 684 173 QC QC NNP 10_1101-2021_01_06_425584 684 174 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 684 175 NG NG NNP 10_1101-2021_01_06_425584 684 176 QC QC NNP 10_1101-2021_01_06_425584 684 177 Glycerophospholipids Glycerophospholipids NNP 10_1101-2021_01_06_425584 684 178 Organooxygen Organooxygen NNP 10_1101-2021_01_06_425584 684 179 compounds compound VBZ 10_1101-2021_01_06_425584 684 180 Fatty Fatty NNP 10_1101-2021_01_06_425584 684 181 acyls acyls NN 10_1101-2021_01_06_425584 684 182 Steroids Steroids NNP 10_1101-2021_01_06_425584 684 183 and and CC 10_1101-2021_01_06_425584 684 184 derivatives derivative VBZ 10_1101-2021_01_06_425584 684 185 Glycerolipids Glycerolipids NNP 10_1101-2021_01_06_425584 684 186 Chemical Chemical NNP 10_1101-2021_01_06_425584 684 187 class class NN 10_1101-2021_01_06_425584 684 188 Indoles indole NNS 10_1101-2021_01_06_425584 684 189 and and CC 10_1101-2021_01_06_425584 684 190 derivatives derivative VBZ 10_1101-2021_01_06_425584 684 191 Organonitrogen Organonitrogen NNP 10_1101-2021_01_06_425584 684 192 compounds compound VBZ 10_1101-2021_01_06_425584 684 193 Coumarins coumarin NNS 10_1101-2021_01_06_425584 684 194 and and CC 10_1101-2021_01_06_425584 684 195 derivatives derivative VBZ 10_1101-2021_01_06_425584 684 196 Connectivity Connectivity NNP 10_1101-2021_01_06_425584 684 197 ( ( -LRB- 10_1101-2021_01_06_425584 684 198 Cosine Cosine NNP 10_1101-2021_01_06_425584 684 199 Score Score NNP 10_1101-2021_01_06_425584 684 200 ) ) -RRB- 10_1101-2021_01_06_425584 684 201 Precursor Precursor NNP 10_1101-2021_01_06_425584 684 202 ion ion NN 10_1101-2021_01_06_425584 684 203 m m NN 10_1101-2021_01_06_425584 684 204 / / SYM 10_1101-2021_01_06_425584 684 205 z z NNP 10_1101-2021_01_06_425584 684 206 value value NN 10_1101-2021_01_06_425584 684 207 Carboxylic carboxylic JJ 10_1101-2021_01_06_425584 684 208 acids acid NNS 10_1101-2021_01_06_425584 684 209 and and CC 10_1101-2021_01_06_425584 684 210 derivatives derivative NNS 10_1101-2021_01_06_425584 684 211 Benzene Benzene NNP 10_1101-2021_01_06_425584 684 212 and and CC 10_1101-2021_01_06_425584 684 213 substituted substitute VBD 10_1101-2021_01_06_425584 684 214 derivatives derivative NNS 10_1101-2021_01_06_425584 684 215 Unknown unknown JJ 10_1101-2021_01_06_425584 684 216 522.3415 522.3415 NN 10_1101-2021_01_06_425584 684 217 194.1019 194.1019 IN 10_1101-2021_01_06_425584 684 218 210.1343 210.1343 CD 10_1101-2021_01_06_425584 684 219 286.0574 286.0574 CD 10_1101-2021_01_06_425584 684 220 703.5731 703.5731 NN 10_1101-2021_01_06_425584 684 221 376.259 376.259 CD 10_1101-2021_01_06_425584 684 222 376.2327 376.2327 CD 10_1101-2021_01_06_425584 684 223 546.2845 546.2845 RB 10_1101-2021_01_06_425584 684 224 575.2753 575.2753 RB 10_1101-2021_01_06_425584 684 225 467.1657 467.1657 NN 10_1101-2021_01_06_425584 684 226 786.5972 786.5972 NN 10_1101-2021_01_06_425584 684 227 264.2317 264.2317 CD 10_1101-2021_01_06_425584 684 228 393.2856 393.2856 CD 10_1101-2021_01_06_425584 684 229 522.355 522.355 CD 10_1101-2021_01_06_425584 684 230 184.1104 184.1104 NNP 10_1101-2021_01_06_425584 684 231 238.1764 238.1764 CD 10_1101-2021_01_06_425584 684 232 530.2946 530.2946 CD 10_1101-2021_01_06_425584 684 233 413.6366 413.6366 CD 10_1101-2021_01_06_425584 684 234 227.0673425.1357 227.0673425.1357 CD 10_1101-2021_01_06_425584 684 235 307.0978 307.0978 CD 10_1101-2021_01_06_425584 684 236 701.5589 701.5589 NNP 10_1101-2021_01_06_425584 684 237 760.5815 760.5815 CD 10_1101-2021_01_06_425584 684 238 327.0837 327.0837 NN 10_1101-2021_01_06_425584 684 239 367.3351 367.3351 CD 10_1101-2021_01_06_425584 684 240 507.1058 507.1058 RB 10_1101-2021_01_06_425584 684 241 390.0094 390.0094 IN 10_1101-2021_01_06_425584 684 242 448.2113 448.2113 NNS 10_1101-2021_01_06_425584 684 243 418.3511 418.3511 CD 10_1101-2021_01_06_425584 684 244 291.0476 291.0476 CD 10_1101-2021_01_06_425584 684 245 538.2512 538.2512 NNP 10_1101-2021_01_06_425584 684 246 472.2715 472.2715 CD 10_1101-2021_01_06_425584 684 247 505.105 505.105 CD 10_1101-2021_01_06_425584 684 248 161.096 161.096 CD 10_1101-2021_01_06_425584 684 249 246.0794 246.0794 CD 10_1101-2021_01_06_425584 684 250 376.2308 376.2308 XX 10_1101-2021_01_06_425584 684 251 283.0944 283.0944 CD 10_1101-2021_01_06_425584 684 252 575.2728 575.2728 RB 10_1101-2021_01_06_425584 684 253 264.0784 264.0784 CD 10_1101-2021_01_06_425584 684 254 675.5421 675.5421 CD 10_1101-2021_01_06_425584 684 255 283.1171 283.1171 CD 10_1101-2021_01_06_425584 684 256 440.2142 440.2142 NNP 10_1101-2021_01_06_425584 684 257 699.612 699.612 CD 10_1101-2021_01_06_425584 684 258 * * NFP 10_1101-2021_01_06_425584 684 259 * * NFP 10_1101-2021_01_06_425584 684 260 PC(18:0/18:2(9Z,12Z PC(18:0/18:2(9Z,12Z NNP 10_1101-2021_01_06_425584 684 261 ) ) -RRB- 10_1101-2021_01_06_425584 684 262 ) ) -RRB- 10_1101-2021_01_06_425584 684 263 O o UH 10_1101-2021_01_06_425584 684 264 P p NN 10_1101-2021_01_06_425584 684 265 O o NN 10_1101-2021_01_06_425584 684 266 OO oo NN 10_1101-2021_01_06_425584 684 267 N+ n+ JJ 10_1101-2021_01_06_425584 684 268 O o NN 10_1101-2021_01_06_425584 684 269 O o NN 10_1101-2021_01_06_425584 684 270 O o NN 10_1101-2021_01_06_425584 684 271 O o NN 10_1101-2021_01_06_425584 684 272 PC(16:0/18:1(9Z pc(16:0/18:1(9z NN 10_1101-2021_01_06_425584 684 273 ) ) -RRB- 10_1101-2021_01_06_425584 684 274 ) ) -RRB- 10_1101-2021_01_06_425584 684 275 O o UH 10_1101-2021_01_06_425584 684 276 P p NN 10_1101-2021_01_06_425584 684 277 O o NN 10_1101-2021_01_06_425584 684 278 OO oo NN 10_1101-2021_01_06_425584 684 279 N+ n+ JJ 10_1101-2021_01_06_425584 684 280 O o NN 10_1101-2021_01_06_425584 684 281 O o NN 10_1101-2021_01_06_425584 684 282 O o NN 10_1101-2021_01_06_425584 684 283 O o NN 10_1101-2021_01_06_425584 684 284 Cluster cluster NN 10_1101-2021_01_06_425584 684 285 1 1 CD 10_1101-2021_01_06_425584 684 286 588.3571 588.3571 NN 10_1101-2021_01_06_425584 684 287 403.2539 403.2539 NN 10_1101-2021_01_06_425584 684 288 522.3415 522.3415 XX 10_1101-2021_01_06_425584 684 289 289.0601 289.0601 CD 10_1101-2021_01_06_425584 684 290 443.112 443.112 CD 10_1101-2021_01_06_425584 684 291 884.5907 884.5907 NNP 10_1101-2021_01_06_425584 684 292 413.1411 413.1411 NNP 10_1101-2021_01_06_425584 684 293 295.1284 295.1284 VBZ 10_1101-2021_01_06_425584 684 294 367.2373 367.2373 NN 10_1101-2021_01_06_425584 684 295 429.1976 429.1976 CD 10_1101-2021_01_06_425584 684 296 194.1019 194.1019 CD 10_1101-2021_01_06_425584 684 297 399.349 399.349 CD 10_1101-2021_01_06_425584 684 298 277.1856 277.1856 CD 10_1101-2021_01_06_425584 684 299 514.128 514.128 CD 10_1101-2021_01_06_425584 684 300 414.6985 414.6985 CD 10_1101-2021_01_06_425584 684 301 600.2445 600.2445 IN 10_1101-2021_01_06_425584 684 302 181.6122 181.6122 CD 10_1101-2021_01_06_425584 684 303 118.086 118.086 CD 10_1101-2021_01_06_425584 684 304 212.1178 212.1178 CD 10_1101-2021_01_06_425584 684 305 386.2386 386.2386 JJ 10_1101-2021_01_06_425584 684 306 545.1027 545.1027 IN 10_1101-2021_01_06_425584 684 307 271.0785 271.0785 CD 10_1101-2021_01_06_425584 684 308 540.1645 540.1645 JJ 10_1101-2021_01_06_425584 684 309 664.4615 664.4615 CD 10_1101-2021_01_06_425584 684 310 713.4423 713.4423 CD 10_1101-2021_01_06_425584 684 311 404.2208 404.2208 NNS 10_1101-2021_01_06_425584 684 312 413.2847 413.2847 NNP 10_1101-2021_01_06_425584 684 313 455.1888 455.1888 CD 10_1101-2021_01_06_425584 684 314 212.1424 212.1424 CD 10_1101-2021_01_06_425584 684 315 345.1096 345.1096 NNP 10_1101-2021_01_06_425584 684 316 481.2106 481.2106 NNP 10_1101-2021_01_06_425584 684 317 401.3451386.3258 401.3451386.3258 CD 10_1101-2021_01_06_425584 684 318 623.364 623.364 CD 10_1101-2021_01_06_425584 684 319 460.311 460.311 CD 10_1101-2021_01_06_425584 684 320 615.1719 615.1719 CD 10_1101-2021_01_06_425584 684 321 462.2474 462.2474 CD 10_1101-2021_01_06_425584 684 322 658.375 658.375 CD 10_1101-2021_01_06_425584 684 323 423.2506 423.2506 CD 10_1101-2021_01_06_425584 684 324 301.169 301.169 CD 10_1101-2021_01_06_425584 684 325 475.3242 475.3242 CD 10_1101-2021_01_06_425584 684 326 436.3157 436.3157 CD 10_1101-2021_01_06_425584 684 327 133.0648 133.0648 CD 10_1101-2021_01_06_425584 684 328 507.1667 507.1667 CD 10_1101-2021_01_06_425584 684 329 369.3511 369.3511 IN 10_1101-2021_01_06_425584 684 330 360.2117 360.2117 NN 10_1101-2021_01_06_425584 684 331 550.1585 550.1585 CD 10_1101-2021_01_06_425584 684 332 210.1343 210.1343 CD 10_1101-2021_01_06_425584 684 333 391.1352 391.1352 NN 10_1101-2021_01_06_425584 684 334 309.1828 309.1828 NNP 10_1101-2021_01_06_425584 684 335 462.2255 462.2255 NN 10_1101-2021_01_06_425584 684 336 516.3869 516.3869 UH 10_1101-2021_01_06_425584 684 337 567.2984 567.2984 JJ 10_1101-2021_01_06_425584 684 338 562.1643 562.1643 NNP 10_1101-2021_01_06_425584 684 339 299.1096 299.1096 NNP 10_1101-2021_01_06_425584 684 340 382.2582 382.2582 NN 10_1101-2021_01_06_425584 684 341 238.1065 238.1065 CD 10_1101-2021_01_06_425584 684 342 382.527 382.527 CD 10_1101-2021_01_06_425584 684 343 332.2428 332.2428 NN 10_1101-2021_01_06_425584 684 344 349.1834 349.1834 NN 10_1101-2021_01_06_425584 684 345 642.613 642.613 CD 10_1101-2021_01_06_425584 684 346 299.1441 299.1441 CD 10_1101-2021_01_06_425584 684 347 490.2817 490.2817 CD 10_1101-2021_01_06_425584 684 348 253.2143 253.2143 IN 10_1101-2021_01_06_425584 684 349 500.2991 500.2991 NN 10_1101-2021_01_06_425584 684 350 465.2575 465.2575 JJ 10_1101-2021_01_06_425584 684 351 449.1492 449.1492 NNS 10_1101-2021_01_06_425584 684 352 322.1153 322.1153 CD 10_1101-2021_01_06_425584 684 353 299.0619 299.0619 CD 10_1101-2021_01_06_425584 684 354 337.0757 337.0757 CD 10_1101-2021_01_06_425584 684 355 436.1964 436.1964 CD 10_1101-2021_01_06_425584 684 356 371.1907 371.1907 NNP 10_1101-2021_01_06_425584 684 357 367.1969 367.1969 NNP 10_1101-2021_01_06_425584 684 358 757.4697 757.4697 NNP 10_1101-2021_01_06_425584 684 359 316.2243 316.2243 NNP 10_1101-2021_01_06_425584 684 360 409.2795 409.2795 NNP 10_1101-2021_01_06_425584 684 361 371.0673 371.0673 NNP 10_1101-2021_01_06_425584 684 362 585.2858 585.2858 NNP 10_1101-2021_01_06_425584 684 363 244.1903 244.1903 CD 10_1101-2021_01_06_425584 684 364 344.1112 344.1112 NNP 10_1101-2021_01_06_425584 684 365 360.3446 360.3446 NNP 10_1101-2021_01_06_425584 684 366 217.1478 217.1478 NN 10_1101-2021_01_06_425584 684 367 390.2615 390.2615 POS 10_1101-2021_01_06_425584 684 368 381.1105 381.1105 NNP 10_1101-2021_01_06_425584 684 369 587.2967 587.2967 CD 10_1101-2021_01_06_425584 684 370 345.2034 345.2034 NNP 10_1101-2021_01_06_425584 684 371 301.0599 301.0599 NN 10_1101-2021_01_06_425584 684 372 319.2257 319.2257 NN 10_1101-2021_01_06_425584 684 373 273.0908 273.0908 CD 10_1101-2021_01_06_425584 684 374 343.2142 343.2142 CD 10_1101-2021_01_06_425584 684 375 490.1759 490.1759 NNP 10_1101-2021_01_06_425584 684 376 520.3321 520.3321 NNP 10_1101-2021_01_06_425584 684 377 699.5139 699.5139 NNP 10_1101-2021_01_06_425584 684 378 629.159 629.159 CD 10_1101-2021_01_06_425584 684 379 441.7374 441.7374 CD 10_1101-2021_01_06_425584 684 380 292.1173 292.1173 CD 10_1101-2021_01_06_425584 684 381 456.2792 456.2792 CD 10_1101-2021_01_06_425584 684 382 396.0879 396.0879 NNP 10_1101-2021_01_06_425584 684 383 398.7747 398.7747 NNP 10_1101-2021_01_06_425584 684 384 309.1296 309.1296 NNP 10_1101-2021_01_06_425584 684 385 401.1592 401.1592 NNP 10_1101-2021_01_06_425584 684 386 313.2729 313.2729 NNP 10_1101-2021_01_06_425584 684 387 528.3076 528.3076 UH 10_1101-2021_01_06_425584 684 388 419.1089 419.1089 VBZ 10_1101-2021_01_06_425584 684 389 594.2896 594.2896 VBP 10_1101-2021_01_06_425584 684 390 655.3817 655.3817 UH 10_1101-2021_01_06_425584 684 391 531.2728 531.2728 RB 10_1101-2021_01_06_425584 684 392 477.1781 477.1781 XX 10_1101-2021_01_06_425584 684 393 286.0574 286.0574 CD 10_1101-2021_01_06_425584 684 394 114.0912 114.0912 NNP 10_1101-2021_01_06_425584 684 395 181.1218 181.1218 NNP 10_1101-2021_01_06_425584 684 396 536.1638 536.1638 NNP 10_1101-2021_01_06_425584 684 397 566.3353 566.3353 XX 10_1101-2021_01_06_425584 684 398 789.4651 789.4651 NNS 10_1101-2021_01_06_425584 684 399 229.1418 229.1418 CD 10_1101-2021_01_06_425584 684 400 185.0804 185.0804 IN 10_1101-2021_01_06_425584 684 401 316.2842 316.2842 IN 10_1101-2021_01_06_425584 684 402 349.2379 349.2379 NNP 10_1101-2021_01_06_425584 684 403 331.2598 331.2598 NNP 10_1101-2021_01_06_425584 684 404 258.1688 258.1688 NNP 10_1101-2021_01_06_425584 684 405 422.3033 422.3033 NNP 10_1101-2021_01_06_425584 684 406 495.2392 495.2392 CD 10_1101-2021_01_06_425584 684 407 509.2865 509.2865 NN 10_1101-2021_01_06_425584 684 408 550.2611 550.2611 RB 10_1101-2021_01_06_425584 684 409 306.2272 306.2272 NNP 10_1101-2021_01_06_425584 684 410 378.2235 378.2235 NNP 10_1101-2021_01_06_425584 684 411 358.135 358.135 CD 10_1101-2021_01_06_425584 684 412 230.1749 230.1749 CD 10_1101-2021_01_06_425584 684 413 387.083 387.083 CD 10_1101-2021_01_06_425584 684 414 442.8012 442.8012 CD 10_1101-2021_01_06_425584 684 415 751.5126 751.5126 CD 10_1101-2021_01_06_425584 684 416 305.6453 305.6453 NN 10_1101-2021_01_06_425584 684 417 768.5299 768.5299 NNP 10_1101-2021_01_06_425584 684 418 455.247 455.247 CD 10_1101-2021_01_06_425584 684 419 444.3311 444.3311 JJ 10_1101-2021_01_06_425584 684 420 298.0777 298.0777 CD 10_1101-2021_01_06_425584 684 421 703.5731 703.5731 NNP 10_1101-2021_01_06_425584 684 422 318.2987 318.2987 NNP 10_1101-2021_01_06_425584 684 423 358.1104 358.1104 NNP 10_1101-2021_01_06_425584 684 424 330.0751 330.0751 CD 10_1101-2021_01_06_425584 684 425 632.3741 632.3741 CD 10_1101-2021_01_06_425584 684 426 376.259 376.259 CD 10_1101-2021_01_06_425584 684 427 475.1924 475.1924 NNP 10_1101-2021_01_06_425584 684 428 414.1404 414.1404 CD 10_1101-2021_01_06_425584 684 429 273.2528 273.2528 CD 10_1101-2021_01_06_425584 684 430 273.1396 273.1396 CD 10_1101-2021_01_06_425584 684 431 385.1528 385.1528 NN 10_1101-2021_01_06_425584 684 432 213.1103 213.1103 CD 10_1101-2021_01_06_425584 684 433 398.2412 398.2412 NN 10_1101-2021_01_06_425584 684 434 446.2587 446.2587 CD 10_1101-2021_01_06_425584 684 435 540.2848 540.2848 CD 10_1101-2021_01_06_425584 684 436 801.4936 801.4936 NNP 10_1101-2021_01_06_425584 684 437 353.1448 353.1448 NNP 10_1101-2021_01_06_425584 684 438 283.1749 283.1749 NNP 10_1101-2021_01_06_425584 684 439 304.8924 304.8924 NNP 10_1101-2021_01_06_425584 684 440 504.2723 504.2723 RB 10_1101-2021_01_06_425584 684 441 565.3329 565.3329 IN 10_1101-2021_01_06_425584 684 442 355.1119 355.1119 CD 10_1101-2021_01_06_425584 684 443 279.0797 279.0797 CD 10_1101-2021_01_06_425584 684 444 593.1553 593.1553 XX 10_1101-2021_01_06_425584 684 445 497.2902 497.2902 CD 10_1101-2021_01_06_425584 684 446 202.0859 202.0859 CD 10_1101-2021_01_06_425584 684 447 216.1608 216.1608 CD 10_1101-2021_01_06_425584 684 448 376.2327 376.2327 CD 10_1101-2021_01_06_425584 684 449 359.3151 359.3151 NN 10_1101-2021_01_06_425584 684 450 400.3045 400.3045 CD 10_1101-2021_01_06_425584 684 451 474.1614 474.1614 CD 10_1101-2021_01_06_425584 684 452 711.1412 711.1412 NNP 10_1101-2021_01_06_425584 684 453 319.1052 319.1052 CD 10_1101-2021_01_06_425584 684 454 486.0965 486.0965 NNP 10_1101-2021_01_06_425584 684 455 696.6349 696.6349 NNP 10_1101-2021_01_06_425584 684 456 407.1877 407.1877 NNP 10_1101-2021_01_06_425584 684 457 331.9947 331.9947 NNP 10_1101-2021_01_06_425584 684 458 230.1386 230.1386 UH 10_1101-2021_01_06_425584 684 459 439.2532 439.2532 NNP 10_1101-2021_01_06_425584 684 460 506.2452 506.2452 NNP 10_1101-2021_01_06_425584 684 461 285.1309 285.1309 CD 10_1101-2021_01_06_425584 684 462 504.1222 504.1222 CD 10_1101-2021_01_06_425584 684 463 414.2137 414.2137 CD 10_1101-2021_01_06_425584 684 464 498.4031 498.4031 NN 10_1101-2021_01_06_425584 684 465 546.2845 546.2845 NNP 10_1101-2021_01_06_425584 684 466 509.1202 509.1202 NNP 10_1101-2021_01_06_425584 684 467 867.5631 867.5631 NN 10_1101-2021_01_06_425584 684 468 475.2779 475.2779 CD 10_1101-2021_01_06_425584 684 469 434.2584 434.2584 CD 10_1101-2021_01_06_425584 684 470 817.4667 817.4667 CD 10_1101-2021_01_06_425584 684 471 348.1855 348.1855 IN 10_1101-2021_01_06_425584 684 472 575.2753 575.2753 RB 10_1101-2021_01_06_425584 684 473 200.1057 200.1057 NNP 10_1101-2021_01_06_425584 684 474 407.0865 407.0865 CD 10_1101-2021_01_06_425584 684 475 612.4165 612.4165 CD 10_1101-2021_01_06_425584 684 476 375.0856 375.0856 NN 10_1101-2021_01_06_425584 684 477 467.1657 467.1657 NN 10_1101-2021_01_06_425584 684 478 564.358 564.358 CD 10_1101-2021_01_06_425584 684 479 377.2349 377.2349 NNP 10_1101-2021_01_06_425584 684 480 174.9548 174.9548 CD 10_1101-2021_01_06_425584 684 481 386.2077 386.2077 NNP 10_1101-2021_01_06_425584 684 482 338.1949 338.1949 CD 10_1101-2021_01_06_425584 684 483 314.2003 314.2003 NNP 10_1101-2021_01_06_425584 684 484 786.5972 786.5972 NNP 10_1101-2021_01_06_425584 684 485 415.2237 415.2237 CD 10_1101-2021_01_06_425584 684 486 419.17 419.17 CD 10_1101-2021_01_06_425584 684 487 264.2317 264.2317 CD 10_1101-2021_01_06_425584 684 488 313.2128 313.2128 CD 10_1101-2021_01_06_425584 684 489 225.0906 225.0906 NN 10_1101-2021_01_06_425584 684 490 233.1838 233.1838 CD 10_1101-2021_01_06_425584 684 491 393.2856 393.2856 NN 10_1101-2021_01_06_425584 684 492 257.0585 257.0585 NNP 10_1101-2021_01_06_425584 684 493 276.1806 276.1806 CD 10_1101-2021_01_06_425584 684 494 527.156 527.156 CD 10_1101-2021_01_06_425584 684 495 377.0441 377.0441 NN 10_1101-2021_01_06_425584 684 496 232.6427 232.6427 CD 10_1101-2021_01_06_425584 684 497 297.1442 297.1442 CD 10_1101-2021_01_06_425584 684 498 933.571 933.571 CD 10_1101-2021_01_06_425584 684 499 411.2079 411.2079 CD 10_1101-2021_01_06_425584 684 500 430.2003 430.2003 CD 10_1101-2021_01_06_425584 684 501 437.1154 437.1154 CD 10_1101-2021_01_06_425584 684 502 197.116 197.116 CD 10_1101-2021_01_06_425584 684 503 239.9349 239.9349 CD 10_1101-2021_01_06_425584 684 504 928.6203 928.6203 CD 10_1101-2021_01_06_425584 684 505 261.2528 261.2528 VBD 10_1101-2021_01_06_425584 684 506 522.355 522.355 CD 10_1101-2021_01_06_425584 684 507 319.1367 319.1367 NNP 10_1101-2021_01_06_425584 684 508 328.1327 328.1327 NNP 10_1101-2021_01_06_425584 684 509 420.7869 420.7869 NN 10_1101-2021_01_06_425584 684 510 129.069 129.069 CD 10_1101-2021_01_06_425584 684 511 403.1745 403.1745 CD 10_1101-2021_01_06_425584 684 512 506.2405 506.2405 NNP 10_1101-2021_01_06_425584 684 513 271.0781 271.0781 CD 10_1101-2021_01_06_425584 684 514 232.1639 232.1639 CD 10_1101-2021_01_06_425584 684 515 244.2086 244.2086 CD 10_1101-2021_01_06_425584 684 516 354.2356 354.2356 NN 10_1101-2021_01_06_425584 684 517 889.5489 889.5489 NNP 10_1101-2021_01_06_425584 684 518 390.2321 390.2321 NNP 10_1101-2021_01_06_425584 684 519 544.3316 544.3316 NNP 10_1101-2021_01_06_425584 684 520 107.0795 107.0795 RB 10_1101-2021_01_06_425584 684 521 288.2526 288.2526 CD 10_1101-2021_01_06_425584 684 522 399.222 399.222 CD 10_1101-2021_01_06_425584 684 523 338.0442 338.0442 NNP 10_1101-2021_01_06_425584 684 524 223.0626 223.0626 CD 10_1101-2021_01_06_425584 684 525 439.1149 439.1149 CD 10_1101-2021_01_06_425584 684 526 298.2223 298.2223 CD 10_1101-2021_01_06_425584 684 527 184.1104 184.1104 NNP 10_1101-2021_01_06_425584 684 528 369.0139 369.0139 NNP 10_1101-2021_01_06_425584 684 529 768.5354 768.5354 CD 10_1101-2021_01_06_425584 684 530 294.1536 294.1536 CD 10_1101-2021_01_06_425584 684 531 448.1644 448.1644 CD 10_1101-2021_01_06_425584 684 532 301.1202 301.1202 IN 10_1101-2021_01_06_425584 684 533 404.1451 404.1451 JJ 10_1101-2021_01_06_425584 684 534 242.116 242.116 CD 10_1101-2021_01_06_425584 684 535 304.2111 304.2111 NN 10_1101-2021_01_06_425584 684 536 299.199 299.199 CD 10_1101-2021_01_06_425584 684 537 578.3353 578.3353 CD 10_1101-2021_01_06_425584 684 538 172.1334 172.1334 CD 10_1101-2021_01_06_425584 684 539 277.0957 277.0957 CD 10_1101-2021_01_06_425584 684 540 315.264 315.264 CD 10_1101-2021_01_06_425584 684 541 232.1536 232.1536 NN 10_1101-2021_01_06_425584 684 542 497.2898 497.2898 NNP 10_1101-2021_01_06_425584 684 543 678.5877 678.5877 NNP 10_1101-2021_01_06_425584 684 544 632.4042 632.4042 IN 10_1101-2021_01_06_425584 684 545 567.3284 567.3284 CD 10_1101-2021_01_06_425584 684 546 633.737 633.737 CD 10_1101-2021_01_06_425584 684 547 304.0625 304.0625 NN 10_1101-2021_01_06_425584 684 548 284.1591 284.1591 CD 10_1101-2021_01_06_425584 684 549 203.1064 203.1064 CD 10_1101-2021_01_06_425584 684 550 272.2211 272.2211 CD 10_1101-2021_01_06_425584 684 551 443.2961 443.2961 CD 10_1101-2021_01_06_425584 684 552 238.1764 238.1764 CD 10_1101-2021_01_06_425584 684 553 359.0625 359.0625 NN 10_1101-2021_01_06_425584 684 554 385.2079 385.2079 NNP 10_1101-2021_01_06_425584 684 555 245.1861 245.1861 NNP 10_1101-2021_01_06_425584 684 556 713.1472 713.1472 NNP 10_1101-2021_01_06_425584 684 557 358.2426 358.2426 NNP 10_1101-2021_01_06_425584 684 558 423.136 423.136 CD 10_1101-2021_01_06_425584 684 559 229.1379 229.1379 CD 10_1101-2021_01_06_425584 684 560 327.1659 327.1659 CD 10_1101-2021_01_06_425584 684 561 302.1146 302.1146 CD 10_1101-2021_01_06_425584 684 562 477.2296 477.2296 CD 10_1101-2021_01_06_425584 684 563 297.154 297.154 CD 10_1101-2021_01_06_425584 684 564 548.157 548.157 CD 10_1101-2021_01_06_425584 684 565 502.0925 502.0925 CD 10_1101-2021_01_06_425584 684 566 399.3618 399.3618 NNP 10_1101-2021_01_06_425584 684 567 394.0924 394.0924 NNP 10_1101-2021_01_06_425584 684 568 307.1737 307.1737 NNP 10_1101-2021_01_06_425584 684 569 301.1301 301.1301 NNP 10_1101-2021_01_06_425584 684 570 301.2823 301.2823 NNP 10_1101-2021_01_06_425584 684 571 796.5661 796.5661 NNP 10_1101-2021_01_06_425584 684 572 309.1275 309.1275 CD 10_1101-2021_01_06_425584 684 573 693.2997 693.2997 JJ 10_1101-2021_01_06_425584 684 574 536.1732 536.1732 NNP 10_1101-2021_01_06_425584 684 575 316.2115 316.2115 CD 10_1101-2021_01_06_425584 684 576 388.1274 388.1274 CD 10_1101-2021_01_06_425584 684 577 483.2052 483.2052 CD 10_1101-2021_01_06_425584 684 578 331.1683 331.1683 NNP 10_1101-2021_01_06_425584 684 579 551.3183 551.3183 NNP 10_1101-2021_01_06_425584 684 580 353.1478 353.1478 NNP 10_1101-2021_01_06_425584 684 581 473.2587 473.2587 NNP 10_1101-2021_01_06_425584 684 582 654.3295 654.3295 VBD 10_1101-2021_01_06_425584 684 583 558.7383 558.7383 CD 10_1101-2021_01_06_425584 684 584 530.2946 530.2946 IN 10_1101-2021_01_06_425584 684 585 508.3023 508.3023 CD 10_1101-2021_01_06_425584 684 586 659.359 659.359 CD 10_1101-2021_01_06_425584 684 587 473.234 473.234 CD 10_1101-2021_01_06_425584 684 588 383.2783 383.2783 NN 10_1101-2021_01_06_425584 684 589 443.1717 443.1717 NN 10_1101-2021_01_06_425584 684 590 664.1098 664.1098 XX 10_1101-2021_01_06_425584 684 591 231.1589 231.1589 CD 10_1101-2021_01_06_425584 684 592 267.0061 267.0061 CD 10_1101-2021_01_06_425584 684 593 500.2756 500.2756 CD 10_1101-2021_01_06_425584 684 594 679.4094 679.4094 CD 10_1101-2021_01_06_425584 684 595 433.2468 433.2468 CD 10_1101-2021_01_06_425584 684 596 630.8588 630.8588 CD 10_1101-2021_01_06_425584 684 597 409.1622 409.1622 CD 10_1101-2021_01_06_425584 684 598 319.2253 319.2253 NNP 10_1101-2021_01_06_425584 684 599 250.1779 250.1779 NNP 10_1101-2021_01_06_425584 684 600 247.013 247.013 CD 10_1101-2021_01_06_425584 684 601 329.0054 329.0054 NNP 10_1101-2021_01_06_425584 684 602 691.4994 691.4994 CD 10_1101-2021_01_06_425584 684 603 315.195 315.195 CD 10_1101-2021_01_06_425584 684 604 474.2317 474.2317 CD 10_1101-2021_01_06_425584 684 605 358.2043 358.2043 NNS 10_1101-2021_01_06_425584 684 606 438.2635 438.2635 CD 10_1101-2021_01_06_425584 684 607 239.1529 239.1529 CD 10_1101-2021_01_06_425584 684 608 299.0617 299.0617 CD 10_1101-2021_01_06_425584 684 609 180.1749 180.1749 CD 10_1101-2021_01_06_425584 684 610 433.2028 433.2028 CD 10_1101-2021_01_06_425584 684 611 291.1168 291.1168 CD 10_1101-2021_01_06_425584 684 612 296.2214 296.2214 NNP 10_1101-2021_01_06_425584 684 613 300.0763 300.0763 NNP 10_1101-2021_01_06_425584 684 614 387.1685 387.1685 NNP 10_1101-2021_01_06_425584 684 615 320.1042 320.1042 CD 10_1101-2021_01_06_425584 684 616 716.5212 716.5212 CD 10_1101-2021_01_06_425584 684 617 587.3253 587.3253 NN 10_1101-2021_01_06_425584 684 618 236.0713 236.0713 NNP 10_1101-2021_01_06_425584 684 619 197.0779 197.0779 CD 10_1101-2021_01_06_425584 684 620 151.075 151.075 CD 10_1101-2021_01_06_425584 684 621 413.6366 413.6366 CD 10_1101-2021_01_06_425584 684 622 531.3313 531.3313 NNP 10_1101-2021_01_06_425584 684 623 851.3932 851.3932 NNP 10_1101-2021_01_06_425584 684 624 227.0673 227.0673 CD 10_1101-2021_01_06_425584 684 625 429.2316 429.2316 CD 10_1101-2021_01_06_425584 684 626 246.1521 246.1521 JJ 10_1101-2021_01_06_425584 684 627 453.21 453.21 CD 10_1101-2021_01_06_425584 684 628 329.202 329.202 CD 10_1101-2021_01_06_425584 684 629 652.4089 652.4089 CD 10_1101-2021_01_06_425584 684 630 270.0416 270.0416 MD 10_1101-2021_01_06_425584 684 631 552.1533 552.1533 CD 10_1101-2021_01_06_425584 684 632 371.0477 371.0477 NN 10_1101-2021_01_06_425584 684 633 338.1339 338.1339 NNP 10_1101-2021_01_06_425584 684 634 613.1577 613.1577 NNP 10_1101-2021_01_06_425584 684 635 334.9126 334.9126 NNP 10_1101-2021_01_06_425584 684 636 374.1591 374.1591 NN 10_1101-2021_01_06_425584 684 637 309.1524 309.1524 CD 10_1101-2021_01_06_425584 684 638 522.3083 522.3083 IN 10_1101-2021_01_06_425584 684 639 541.2215 541.2215 NNP 10_1101-2021_01_06_425584 684 640 415.2797 415.2797 NNP 10_1101-2021_01_06_425584 684 641 376.1159 376.1159 NNP 10_1101-2021_01_06_425584 684 642 734.6477 734.6477 NNP 10_1101-2021_01_06_425584 684 643 257.0572 257.0572 CD 10_1101-2021_01_06_425584 684 644 283.6001 283.6001 CD 10_1101-2021_01_06_425584 684 645 331.0834 331.0834 VBZ 10_1101-2021_01_06_425584 684 646 374.0627 374.0627 NNP 10_1101-2021_01_06_425584 684 647 592.3889 592.3889 XX 10_1101-2021_01_06_425584 684 648 246.1016 246.1016 RB 10_1101-2021_01_06_425584 684 649 425.1357 425.1357 NN 10_1101-2021_01_06_425584 684 650 331.2049 331.2049 CD 10_1101-2021_01_06_425584 684 651 575.209 575.209 CD 10_1101-2021_01_06_425584 684 652 404.7346 404.7346 CD 10_1101-2021_01_06_425584 684 653 348.1212 348.1212 NN 10_1101-2021_01_06_425584 684 654 283.1205 283.1205 CD 10_1101-2021_01_06_425584 684 655 242.0992 242.0992 CD 10_1101-2021_01_06_425584 684 656 478.292 478.292 CD 10_1101-2021_01_06_425584 684 657 377.1814 377.1814 CD 10_1101-2021_01_06_425584 684 658 345.1106 345.1106 CD 10_1101-2021_01_06_425584 684 659 285.007 285.007 CD 10_1101-2021_01_06_425584 684 660 640.268 640.268 CD 10_1101-2021_01_06_425584 684 661 307.0978 307.0978 NNP 10_1101-2021_01_06_425584 684 662 240.1799 240.1799 CD 10_1101-2021_01_06_425584 684 663 402.0959 402.0959 NNP 10_1101-2021_01_06_425584 684 664 701.5589 701.5589 NNP 10_1101-2021_01_06_425584 684 665 404.2348 404.2348 CD 10_1101-2021_01_06_425584 684 666 661.5624 661.5624 NNP 10_1101-2021_01_06_425584 684 667 331.1573 331.1573 NNP 10_1101-2021_01_06_425584 684 668 353.2221 353.2221 NNP 10_1101-2021_01_06_425584 684 669 509.2995 509.2995 NNP 10_1101-2021_01_06_425584 684 670 265.1674 265.1674 CD 10_1101-2021_01_06_425584 684 671 283.1263 283.1263 NN 10_1101-2021_01_06_425584 684 672 416.0969 416.0969 CD 10_1101-2021_01_06_425584 684 673 509.2353 509.2353 XX 10_1101-2021_01_06_425584 684 674 487.1958 487.1958 JJ 10_1101-2021_01_06_425584 684 675 620.4355 620.4355 JJ 10_1101-2021_01_06_425584 684 676 332.0995 332.0995 NNP 10_1101-2021_01_06_425584 684 677 190.1434 190.1434 NNP 10_1101-2021_01_06_425584 684 678 263.0813 263.0813 CD 10_1101-2021_01_06_425584 684 679 760.5815 760.5815 NN 10_1101-2021_01_06_425584 684 680 453.2655 453.2655 JJ 10_1101-2021_01_06_425584 684 681 382.2214 382.2214 NNP 10_1101-2021_01_06_425584 684 682 271.1622 271.1622 CD 10_1101-2021_01_06_425584 684 683 210.0494 210.0494 CD 10_1101-2021_01_06_425584 684 684 309.1573 309.1573 JJ 10_1101-2021_01_06_425584 684 685 493.1866 493.1866 CD 10_1101-2021_01_06_425584 684 686 488.2337 488.2337 CD 10_1101-2021_01_06_425584 684 687 295.1274 295.1274 CD 10_1101-2021_01_06_425584 684 688 273.1677 273.1677 CD 10_1101-2021_01_06_425584 684 689 161.1165 161.1165 IN 10_1101-2021_01_06_425584 684 690 349.2384 349.2384 NNP 10_1101-2021_01_06_425584 684 691 187.1435 187.1435 NNP 10_1101-2021_01_06_425584 684 692 398.0898 398.0898 NN 10_1101-2021_01_06_425584 684 693 428.1321 428.1321 CD 10_1101-2021_01_06_425584 684 694 439.2902 439.2902 CD 10_1101-2021_01_06_425584 684 695 321.1474 321.1474 NN 10_1101-2021_01_06_425584 684 696 535.21 535.21 CD 10_1101-2021_01_06_425584 684 697 204.6112 204.6112 NNP 10_1101-2021_01_06_425584 684 698 446.2585 446.2585 NN 10_1101-2021_01_06_425584 684 699 407.1732 407.1732 CD 10_1101-2021_01_06_425584 684 700 654.19 654.19 CD 10_1101-2021_01_06_425584 684 701 455.3344 455.3344 CD 10_1101-2021_01_06_425584 684 702 500.3049 500.3049 JJ 10_1101-2021_01_06_425584 684 703 409.2372 409.2372 CD 10_1101-2021_01_06_425584 684 704 295.1285 295.1285 CD 10_1101-2021_01_06_425584 684 705 547.331 547.331 CD 10_1101-2021_01_06_425584 684 706 625.2796 625.2796 CD 10_1101-2021_01_06_425584 684 707 375.0536 375.0536 NN 10_1101-2021_01_06_425584 684 708 242.1172 242.1172 CD 10_1101-2021_01_06_425584 684 709 376.2281 376.2281 CD 10_1101-2021_01_06_425584 684 710 209.0914 209.0914 NNP 10_1101-2021_01_06_425584 684 711 597.3382 597.3382 NNP 10_1101-2021_01_06_425584 684 712 370.1355 370.1355 NNP 10_1101-2021_01_06_425584 684 713 270.0645 270.0645 NNP 10_1101-2021_01_06_425584 684 714 541.2606 541.2606 NNP 10_1101-2021_01_06_425584 684 715 671.3161 671.3161 NNP 10_1101-2021_01_06_425584 684 716 276.1258 276.1258 CD 10_1101-2021_01_06_425584 684 717 468.9809 468.9809 CD 10_1101-2021_01_06_425584 684 718 287.0473 287.0473 CD 10_1101-2021_01_06_425584 684 719 320.2047 320.2047 CD 10_1101-2021_01_06_425584 684 720 277.1414 277.1414 CD 10_1101-2021_01_06_425584 684 721 177.0627 177.0627 CD 10_1101-2021_01_06_425584 684 722 504.3367 504.3367 NNP 10_1101-2021_01_06_425584 684 723 735.4868 735.4868 CD 10_1101-2021_01_06_425584 684 724 461.2096 461.2096 NNP 10_1101-2021_01_06_425584 684 725 617.3879 617.3879 CD 10_1101-2021_01_06_425584 684 726 589.3121 589.3121 CD 10_1101-2021_01_06_425584 684 727 202.1068 202.1068 CD 10_1101-2021_01_06_425584 684 728 148.0604 148.0604 CD 10_1101-2021_01_06_425584 684 729 520.295 520.295 CD 10_1101-2021_01_06_425584 684 730 327.0837 327.0837 CD 10_1101-2021_01_06_425584 684 731 347.1596 347.1596 NNP 10_1101-2021_01_06_425584 684 732 556.1906 556.1906 CD 10_1101-2021_01_06_425584 684 733 297.1436 297.1436 NN 10_1101-2021_01_06_425584 684 734 334.0427 334.0427 IN 10_1101-2021_01_06_425584 684 735 206.1392 206.1392 CD 10_1101-2021_01_06_425584 684 736 431.0663 431.0663 CD 10_1101-2021_01_06_425584 684 737 911.594 911.594 CD 10_1101-2021_01_06_425584 684 738 336.1909 336.1909 JJ 10_1101-2021_01_06_425584 684 739 329.1818 329.1818 CD 10_1101-2021_01_06_425584 684 740 608.3826 608.3826 CD 10_1101-2021_01_06_425584 684 741 289.2475 289.2475 CD 10_1101-2021_01_06_425584 684 742 367.3351 367.3351 CD 10_1101-2021_01_06_425584 684 743 156.0483 156.0483 CD 10_1101-2021_01_06_425584 684 744 478.1842 478.1842 CD 10_1101-2021_01_06_425584 684 745 619.2416 619.2416 CD 10_1101-2021_01_06_425584 684 746 404.847 404.847 CD 10_1101-2021_01_06_425584 684 747 465.1608 465.1608 CD 10_1101-2021_01_06_425584 684 748 207.0614 207.0614 CD 10_1101-2021_01_06_425584 684 749 605.4416 605.4416 XX 10_1101-2021_01_06_425584 684 750 579.337 579.337 CD 10_1101-2021_01_06_425584 684 751 242.2114 242.2114 CD 10_1101-2021_01_06_425584 684 752 310.0135 310.0135 NNS 10_1101-2021_01_06_425584 684 753 396.1853 396.1853 CD 10_1101-2021_01_06_425584 684 754 341.206 341.206 CD 10_1101-2021_01_06_425584 684 755 397.2156 397.2156 NNP 10_1101-2021_01_06_425584 684 756 344.2247 344.2247 CD 10_1101-2021_01_06_425584 684 757 433.1485 433.1485 CD 10_1101-2021_01_06_425584 684 758 393.2099 393.2099 CD 10_1101-2021_01_06_425584 684 759 346.1958 346.1958 NNP 10_1101-2021_01_06_425584 684 760 434.0664 434.0664 CD 10_1101-2021_01_06_425584 684 761 398.7746 398.7746 CD 10_1101-2021_01_06_425584 684 762 484.137 484.137 CD 10_1101-2021_01_06_425584 684 763 371.2276 371.2276 CD 10_1101-2021_01_06_425584 684 764 216.1954 216.1954 NNP 10_1101-2021_01_06_425584 684 765 318.1811 318.1811 NNP 10_1101-2021_01_06_425584 684 766 399.1987 399.1987 NNP 10_1101-2021_01_06_425584 684 767 708.4868 708.4868 NNP 10_1101-2021_01_06_425584 684 768 435.1311 435.1311 NNP 10_1101-2021_01_06_425584 684 769 474.2324 474.2324 CD 10_1101-2021_01_06_425584 684 770 383.0228 383.0228 NN 10_1101-2021_01_06_425584 684 771 291.1928 291.1928 . 10_1101-2021_01_06_425584 684 772 316.1778 316.1778 NN 10_1101-2021_01_06_425584 684 773 751.5081 751.5081 VBZ 10_1101-2021_01_06_425584 684 774 467.6187 467.6187 CD 10_1101-2021_01_06_425584 684 775 272.1853 272.1853 CD 10_1101-2021_01_06_425584 684 776 739.6026 739.6026 NN 10_1101-2021_01_06_425584 684 777 434.1648 434.1648 CD 10_1101-2021_01_06_425584 684 778 269.0628 269.0628 CD 10_1101-2021_01_06_425584 684 779 293.6761 293.6761 CD 10_1101-2021_01_06_425584 684 780 744.5533 744.5533 JJ 10_1101-2021_01_06_425584 684 781 302.1702 302.1702 NN 10_1101-2021_01_06_425584 684 782 637.1514 637.1514 CD 10_1101-2021_01_06_425584 684 783 331.109 331.109 CD 10_1101-2021_01_06_425584 684 784 507.1058 507.1058 RB 10_1101-2021_01_06_425584 684 785 416.158 416.158 CD 10_1101-2021_01_06_425584 684 786 369.1843 369.1843 CD 10_1101-2021_01_06_425584 684 787 489.1045 489.1045 NNP 10_1101-2021_01_06_425584 684 788 233.0772 233.0772 CD 10_1101-2021_01_06_425584 684 789 507.1304 507.1304 XX 10_1101-2021_01_06_425584 684 790 407.1706 407.1706 NNP 10_1101-2021_01_06_425584 684 791 298.1856 298.1856 CD 10_1101-2021_01_06_425584 684 792 404.1482 404.1482 CD 10_1101-2021_01_06_425584 684 793 427.305 427.305 CD 10_1101-2021_01_06_425584 684 794 210.1843 210.1843 NNP 10_1101-2021_01_06_425584 684 795 857.3778 857.3778 CD 10_1101-2021_01_06_425584 684 796 729.4168 729.4168 NN 10_1101-2021_01_06_425584 684 797 348.2378 348.2378 CD 10_1101-2021_01_06_425584 684 798 477.2335 477.2335 CD 10_1101-2021_01_06_425584 684 799 409.1764 409.1764 CD 10_1101-2021_01_06_425584 684 800 735.4996 735.4996 CD 10_1101-2021_01_06_425584 684 801 779.5132 779.5132 NNP 10_1101-2021_01_06_425584 684 802 388.2532 388.2532 NNP 10_1101-2021_01_06_425584 684 803 478.2635 478.2635 CD 10_1101-2021_01_06_425584 684 804 431.2514 431.2514 CD 10_1101-2021_01_06_425584 684 805 208.1812 208.1812 CD 10_1101-2021_01_06_425584 684 806 449.2862 449.2862 NNP 10_1101-2021_01_06_425584 684 807 576.4091 576.4091 NNP 10_1101-2021_01_06_425584 684 808 474.2906 474.2906 NNP 10_1101-2021_01_06_425584 684 809 594.1326 594.1326 VBZ 10_1101-2021_01_06_425584 684 810 336.3255 336.3255 NNP 10_1101-2021_01_06_425584 684 811 637.8139 637.8139 JJ 10_1101-2021_01_06_425584 684 812 627.095 627.095 CD 10_1101-2021_01_06_425584 684 813 403.2751 403.2751 CD 10_1101-2021_01_06_425584 684 814 353.2653 353.2653 CD 10_1101-2021_01_06_425584 684 815 683.345 683.345 CD 10_1101-2021_01_06_425584 684 816 325.0998 325.0998 CD 10_1101-2021_01_06_425584 684 817 331.2087 331.2087 CD 10_1101-2021_01_06_425584 684 818 242.2836 242.2836 CD 10_1101-2021_01_06_425584 684 819 450.2319 450.2319 CD 10_1101-2021_01_06_425584 684 820 342.1657 342.1657 NNP 10_1101-2021_01_06_425584 684 821 188.066 188.066 CD 10_1101-2021_01_06_425584 684 822 339.2526 339.2526 CD 10_1101-2021_01_06_425584 684 823 335.158 335.158 CD 10_1101-2021_01_06_425584 684 824 300.2013 300.2013 CD 10_1101-2021_01_06_425584 684 825 659.2866 659.2866 CD 10_1101-2021_01_06_425584 684 826 591.358 591.358 CD 10_1101-2021_01_06_425584 684 827 214.2521 214.2521 CD 10_1101-2021_01_06_425584 684 828 686.4674 686.4674 NN 10_1101-2021_01_06_425584 684 829 545.2051 545.2051 RB 10_1101-2021_01_06_425584 684 830 348.2012 348.2012 NNP 10_1101-2021_01_06_425584 684 831 314.1799 314.1799 NNP 10_1101-2021_01_06_425584 684 832 231.1164 231.1164 NNP 10_1101-2021_01_06_425584 684 833 209.122 209.122 CD 10_1101-2021_01_06_425584 684 834 503.3049 503.3049 NNP 10_1101-2021_01_06_425584 684 835 297.1802 297.1802 NNP 10_1101-2021_01_06_425584 684 836 360.1322 360.1322 CD 10_1101-2021_01_06_425584 684 837 403.2229 403.2229 CD 10_1101-2021_01_06_425584 684 838 455.107 455.107 CD 10_1101-2021_01_06_425584 684 839 322.0628 322.0628 CD 10_1101-2021_01_06_425584 684 840 229.0386 229.0386 CD 10_1101-2021_01_06_425584 684 841 311.1988 311.1988 NNP 10_1101-2021_01_06_425584 684 842 316.061 316.061 CD 10_1101-2021_01_06_425584 684 843 300.0013 300.0013 NNP 10_1101-2021_01_06_425584 684 844 520.3407 520.3407 NNP 10_1101-2021_01_06_425584 684 845 250.1462 250.1462 CD 10_1101-2021_01_06_425584 684 846 446.2248 446.2248 CD 10_1101-2021_01_06_425584 684 847 387.1969 387.1969 CD 10_1101-2021_01_06_425584 684 848 436.1368 436.1368 NN 10_1101-2021_01_06_425584 684 849 480.1787 480.1787 NNP 10_1101-2021_01_06_425584 684 850 390.0094 390.0094 NNP 10_1101-2021_01_06_425584 684 851 334.2211 334.2211 CD 10_1101-2021_01_06_425584 684 852 458.2322 458.2322 CD 10_1101-2021_01_06_425584 684 853 399.3568 399.3568 JJ 10_1101-2021_01_06_425584 684 854 506.2726 506.2726 NNP 10_1101-2021_01_06_425584 684 855 235.1782 235.1782 CD 10_1101-2021_01_06_425584 684 856 389.1216 389.1216 NNP 10_1101-2021_01_06_425584 684 857 452.2747 452.2747 NN 10_1101-2021_01_06_425584 684 858 329.0849 329.0849 NNP 10_1101-2021_01_06_425584 684 859 502.2879 502.2879 CD 10_1101-2021_01_06_425584 684 860 654.3297 654.3297 CD 10_1101-2021_01_06_425584 684 861 385.2046 385.2046 NNS 10_1101-2021_01_06_425584 684 862 421.2828 421.2828 NNP 10_1101-2021_01_06_425584 684 863 433.2463 433.2463 CD 10_1101-2021_01_06_425584 684 864 846.4398 846.4398 NNP 10_1101-2021_01_06_425584 684 865 402.2327 402.2327 NNP 10_1101-2021_01_06_425584 684 866 355.1755 355.1755 NNP 10_1101-2021_01_06_425584 684 867 325.0272 325.0272 NNP 10_1101-2021_01_06_425584 684 868 360.2022 360.2022 CD 10_1101-2021_01_06_425584 684 869 263.1492 263.1492 CD 10_1101-2021_01_06_425584 684 870 447.1673 447.1673 CD 10_1101-2021_01_06_425584 684 871 402.1759 402.1759 CD 10_1101-2021_01_06_425584 684 872 316.3205 316.3205 CD 10_1101-2021_01_06_425584 684 873 610.3903 610.3903 JJ 10_1101-2021_01_06_425584 684 874 396.0943 396.0943 NNP 10_1101-2021_01_06_425584 684 875 157.0855 157.0855 NN 10_1101-2021_01_06_425584 684 876 465.1713 465.1713 NN 10_1101-2021_01_06_425584 684 877 256.0605 256.0605 CD 10_1101-2021_01_06_425584 684 878 518.3147 518.3147 JJ 10_1101-2021_01_06_425584 684 879 773.4406 773.4406 NNP 10_1101-2021_01_06_425584 684 880 653.332 653.332 IN 10_1101-2021_01_06_425584 684 881 331.1648 331.1648 CD 10_1101-2021_01_06_425584 684 882 448.2113 448.2113 VBZ 10_1101-2021_01_06_425584 684 883 511.2145 511.2145 CD 10_1101-2021_01_06_425584 684 884 606.138 606.138 CD 10_1101-2021_01_06_425584 684 885 294.2061 294.2061 CD 10_1101-2021_01_06_425584 684 886 409.1837 409.1837 CD 10_1101-2021_01_06_425584 684 887 198.1845 198.1845 RB 10_1101-2021_01_06_425584 684 888 403.22 403.22 CD 10_1101-2021_01_06_425584 684 889 486.2007 486.2007 CD 10_1101-2021_01_06_425584 684 890 740.5427 740.5427 CD 10_1101-2021_01_06_425584 684 891 560.4098 560.4098 NNP 10_1101-2021_01_06_425584 684 892 345.2984 345.2984 NNP 10_1101-2021_01_06_425584 684 893 669.4164 669.4164 NNP 10_1101-2021_01_06_425584 684 894 480.8023 480.8023 NNP 10_1101-2021_01_06_425584 684 895 407.1805 407.1805 CD 10_1101-2021_01_06_425584 684 896 611.3249 611.3249 NNP 10_1101-2021_01_06_425584 684 897 395.2195 395.2195 NNP 10_1101-2021_01_06_425584 684 898 333.1659 333.1659 NNP 10_1101-2021_01_06_425584 684 899 840.5653 840.5653 NNP 10_1101-2021_01_06_425584 684 900 491.1995 491.1995 NNP 10_1101-2021_01_06_425584 684 901 211.0939 211.0939 NNP 10_1101-2021_01_06_425584 684 902 377.1463 377.1463 NNP 10_1101-2021_01_06_425584 684 903 299.1804 299.1804 NNP 10_1101-2021_01_06_425584 684 904 431.1815 431.1815 CD 10_1101-2021_01_06_425584 684 905 459.1706 459.1706 CD 10_1101-2021_01_06_425584 684 906 329.1689 329.1689 NN 10_1101-2021_01_06_425584 684 907 401.2022 401.2022 VBD 10_1101-2021_01_06_425584 684 908 302.1736 302.1736 CD 10_1101-2021_01_06_425584 684 909 248.108 248.108 CD 10_1101-2021_01_06_425584 684 910 482.3244 482.3244 CD 10_1101-2021_01_06_425584 684 911 823.5398 823.5398 NN 10_1101-2021_01_06_425584 684 912 358.1599 358.1599 NN 10_1101-2021_01_06_425584 684 913 228.0157 228.0157 NNP 10_1101-2021_01_06_425584 684 914 441.1515 441.1515 CD 10_1101-2021_01_06_425584 684 915 247.1286 247.1286 CD 10_1101-2021_01_06_425584 684 916 255.0077 255.0077 NN 10_1101-2021_01_06_425584 684 917 385.1619 385.1619 CD 10_1101-2021_01_06_425584 684 918 534.3515 534.3515 CD 10_1101-2021_01_06_425584 684 919 310.0137 310.0137 NN 10_1101-2021_01_06_425584 684 920 601.3545 601.3545 CD 10_1101-2021_01_06_425584 684 921 307.5846 307.5846 NN 10_1101-2021_01_06_425584 684 922 257.1651 257.1651 CD 10_1101-2021_01_06_425584 684 923 682.583 682.583 CD 10_1101-2021_01_06_425584 684 924 205.0968233.128 205.0968233.128 CD 10_1101-2021_01_06_425584 684 925 311.0851 311.0851 CD 10_1101-2021_01_06_425584 684 926 708.4518 708.4518 CD 10_1101-2021_01_06_425584 684 927 208.9943 208.9943 CD 10_1101-2021_01_06_425584 684 928 367.317 367.317 CD 10_1101-2021_01_06_425584 684 929 502.1256 502.1256 CD 10_1101-2021_01_06_425584 684 930 221.117 221.117 CD 10_1101-2021_01_06_425584 684 931 404.2074 404.2074 CD 10_1101-2021_01_06_425584 684 932 293.0018 293.0018 CD 10_1101-2021_01_06_425584 684 933 418.3511 418.3511 CD 10_1101-2021_01_06_425584 684 934 522.2898 522.2898 NNP 10_1101-2021_01_06_425584 684 935 383.0299 383.0299 NNP 10_1101-2021_01_06_425584 684 936 232.0109 232.0109 CD 10_1101-2021_01_06_425584 684 937 187.0257 187.0257 CD 10_1101-2021_01_06_425584 684 938 625.39 625.39 CD 10_1101-2021_01_06_425584 684 939 315.0742 315.0742 NN 10_1101-2021_01_06_425584 684 940 365.157 365.157 CD 10_1101-2021_01_06_425584 684 941 387.3458 387.3458 NN 10_1101-2021_01_06_425584 684 942 528.1033 528.1033 NNP 10_1101-2021_01_06_425584 684 943 363.1622 363.1622 NN 10_1101-2021_01_06_425584 684 944 415.2539 415.2539 NNP 10_1101-2021_01_06_425584 684 945 399.268 399.268 CD 10_1101-2021_01_06_425584 684 946 291.0476 291.0476 CD 10_1101-2021_01_06_425584 684 947 313.0673 313.0673 NN 10_1101-2021_01_06_425584 684 948 288.3147 288.3147 CD 10_1101-2021_01_06_425584 684 949 415.2449 415.2449 NN 10_1101-2021_01_06_425584 684 950 667.3875 667.3875 NN 10_1101-2021_01_06_425584 684 951 480.3075 480.3075 NN 10_1101-2021_01_06_425584 684 952 602.3388 602.3388 NN 10_1101-2021_01_06_425584 684 953 334.0404 334.0404 NNP 10_1101-2021_01_06_425584 684 954 261.1445 261.1445 CD 10_1101-2021_01_06_425584 684 955 433.2063 433.2063 NNP 10_1101-2021_01_06_425584 684 956 331.9939 331.9939 NNP 10_1101-2021_01_06_425584 684 957 331.1366 331.1366 CD 10_1101-2021_01_06_425584 684 958 243.1336 243.1336 CD 10_1101-2021_01_06_425584 684 959 261.1307 261.1307 CD 10_1101-2021_01_06_425584 684 960 313.068 313.068 CD 10_1101-2021_01_06_425584 684 961 543.1052 543.1052 CD 10_1101-2021_01_06_425584 684 962 331.2228 331.2228 CD 10_1101-2021_01_06_425584 684 963 329.1491 329.1491 CD 10_1101-2021_01_06_425584 684 964 224.185 224.185 CD 10_1101-2021_01_06_425584 684 965 284.0988 284.0988 CD 10_1101-2021_01_06_425584 684 966 497.7717 497.7717 CD 10_1101-2021_01_06_425584 684 967 332.604 332.604 CD 10_1101-2021_01_06_425584 684 968 295.1349 295.1349 CD 10_1101-2021_01_06_425584 684 969 538.2512 538.2512 NNP 10_1101-2021_01_06_425584 684 970 284.2213 284.2213 CD 10_1101-2021_01_06_425584 684 971 257.2212 257.2212 CD 10_1101-2021_01_06_425584 684 972 285.1892 285.1892 CD 10_1101-2021_01_06_425584 684 973 260.1854 260.1854 CD 10_1101-2021_01_06_425584 684 974 561.3954 561.3954 CD 10_1101-2021_01_06_425584 684 975 343.1966 343.1966 CD 10_1101-2021_01_06_425584 684 976 385.0872 385.0872 NNP 10_1101-2021_01_06_425584 684 977 544.3215 544.3215 NNP 10_1101-2021_01_06_425584 684 978 318.8867 318.8867 NNP 10_1101-2021_01_06_425584 684 979 301.1419 301.1419 CD 10_1101-2021_01_06_425584 684 980 214.0972 214.0972 CD 10_1101-2021_01_06_425584 684 981 377.2579 377.2579 CD 10_1101-2021_01_06_425584 684 982 306.094 306.094 CD 10_1101-2021_01_06_425584 684 983 356.077 356.077 CD 10_1101-2021_01_06_425584 684 984 669.2021 669.2021 CD 10_1101-2021_01_06_425584 684 985 717.6223 717.6223 NN 10_1101-2021_01_06_425584 684 986 487.3739 487.3739 NN 10_1101-2021_01_06_425584 684 987 402.1677 402.1677 CD 10_1101-2021_01_06_425584 684 988 204.042 204.042 CD 10_1101-2021_01_06_425584 684 989 683.5415 683.5415 CD 10_1101-2021_01_06_425584 684 990 592.1747430.2644 592.1747430.2644 CD 10_1101-2021_01_06_425584 684 991 421.3172 421.3172 CD 10_1101-2021_01_06_425584 684 992 484.1461 484.1461 CD 10_1101-2021_01_06_425584 684 993 243.0875 243.0875 CD 10_1101-2021_01_06_425584 684 994 597.8556 597.8556 XX 10_1101-2021_01_06_425584 684 995 425.1561 425.1561 NNP 10_1101-2021_01_06_425584 684 996 779.5197 779.5197 NNP 10_1101-2021_01_06_425584 684 997 874.4691 874.4691 CD 10_1101-2021_01_06_425584 684 998 610.2815 610.2815 CD 10_1101-2021_01_06_425584 684 999 575.2665 575.2665 NN 10_1101-2021_01_06_425584 684 1000 362.0542 362.0542 JJ 10_1101-2021_01_06_425584 684 1001 472.2715 472.2715 CD 10_1101-2021_01_06_425584 684 1002 504.3064 504.3064 VBP 10_1101-2021_01_06_425584 684 1003 592.3891 592.3891 NN 10_1101-2021_01_06_425584 684 1004 245.137 245.137 CD 10_1101-2021_01_06_425584 684 1005 414.2359 414.2359 NN 10_1101-2021_01_06_425584 684 1006 342.2119 342.2119 JJ 10_1101-2021_01_06_425584 684 1007 305.2105 305.2105 NN 10_1101-2021_01_06_425584 684 1008 651.257 651.257 CD 10_1101-2021_01_06_425584 684 1009 387.2096 387.2096 IN 10_1101-2021_01_06_425584 684 1010 376.3416 376.3416 CD 10_1101-2021_01_06_425584 684 1011 376.762 376.762 CD 10_1101-2021_01_06_425584 684 1012 505.105 505.105 CD 10_1101-2021_01_06_425584 684 1013 653.3624 653.3624 NNP 10_1101-2021_01_06_425584 684 1014 613.3397 613.3397 CD 10_1101-2021_01_06_425584 684 1015 308.8983 308.8983 NN 10_1101-2021_01_06_425584 684 1016 247.132 247.132 CD 10_1101-2021_01_06_425584 684 1017 368.1613 368.1613 CD 10_1101-2021_01_06_425584 684 1018 289.0533 289.0533 CD 10_1101-2021_01_06_425584 684 1019 237.0678 237.0678 CD 10_1101-2021_01_06_425584 684 1020 311.1281 311.1281 NNP 10_1101-2021_01_06_425584 684 1021 790.3776 790.3776 JJ 10_1101-2021_01_06_425584 684 1022 569.3138 569.3138 NN 10_1101-2021_01_06_425584 684 1023 328.2316 328.2316 NN 10_1101-2021_01_06_425584 684 1024 298.1252 298.1252 CD 10_1101-2021_01_06_425584 684 1025 521.1332 521.1332 CD 10_1101-2021_01_06_425584 684 1026 379.2408 379.2408 CD 10_1101-2021_01_06_425584 684 1027 307.5897 307.5897 NNP 10_1101-2021_01_06_425584 684 1028 120.0809 120.0809 CD 10_1101-2021_01_06_425584 684 1029 459.1915 459.1915 NN 10_1101-2021_01_06_425584 684 1030 685.3904 685.3904 NN 10_1101-2021_01_06_425584 684 1031 443.2189 443.2189 CD 10_1101-2021_01_06_425584 684 1032 544.3519 544.3519 NNP 10_1101-2021_01_06_425584 684 1033 348.3105 348.3105 NNP 10_1101-2021_01_06_425584 684 1034 264.0825 264.0825 NNP 10_1101-2021_01_06_425584 684 1035 648.3785 648.3785 CD 10_1101-2021_01_06_425584 684 1036 274.1444 274.1444 CD 10_1101-2021_01_06_425584 684 1037 541.1202 541.1202 CD 10_1101-2021_01_06_425584 684 1038 550.1643 550.1643 XX 10_1101-2021_01_06_425584 684 1039 306.2638 306.2638 UH 10_1101-2021_01_06_425584 684 1040 472.3602 472.3602 CD 10_1101-2021_01_06_425584 684 1041 219.1125 219.1125 CD 10_1101-2021_01_06_425584 684 1042 642.6193 642.6193 NNP 10_1101-2021_01_06_425584 684 1043 290.1934 290.1934 NNP 10_1101-2021_01_06_425584 684 1044 664.1265 664.1265 CD 10_1101-2021_01_06_425584 684 1045 415.2426 415.2426 CD 10_1101-2021_01_06_425584 684 1046 504.1223 504.1223 CD 10_1101-2021_01_06_425584 684 1047 528.1789 528.1789 IN 10_1101-2021_01_06_425584 684 1048 195.1005 195.1005 NNP 10_1101-2021_01_06_425584 684 1049 290.1952 290.1952 NN 10_1101-2021_01_06_425584 684 1050 190.0339 190.0339 NNP 10_1101-2021_01_06_425584 684 1051 471.1366 471.1366 NNP 10_1101-2021_01_06_425584 684 1052 487.1548 487.1548 CD 10_1101-2021_01_06_425584 684 1053 331.1695 331.1695 NNP 10_1101-2021_01_06_425584 684 1054 412.2519 412.2519 NNP 10_1101-2021_01_06_425584 684 1055 416.2854 416.2854 CD 10_1101-2021_01_06_425584 684 1056 321.0536 321.0536 NNP 10_1101-2021_01_06_425584 684 1057 533.4225 533.4225 CD 10_1101-2021_01_06_425584 684 1058 386.0815 386.0815 NN 10_1101-2021_01_06_425584 684 1059 204.1049 204.1049 CD 10_1101-2021_01_06_425584 684 1060 433.2634 433.2634 CD 10_1101-2021_01_06_425584 684 1061 353.0485 353.0485 CD 10_1101-2021_01_06_425584 684 1062 309.6428 309.6428 CD 10_1101-2021_01_06_425584 684 1063 354.0344 354.0344 NN 10_1101-2021_01_06_425584 684 1064 315.215 315.215 CD 10_1101-2021_01_06_425584 684 1065 518.0863 518.0863 CD 10_1101-2021_01_06_425584 684 1066 409.1898 409.1898 NN 10_1101-2021_01_06_425584 684 1067 635.3845 635.3845 NN 10_1101-2021_01_06_425584 684 1068 796.5389 796.5389 NNS 10_1101-2021_01_06_425584 684 1069 537.3384 537.3384 CD 10_1101-2021_01_06_425584 684 1070 227.1646 227.1646 CD 10_1101-2021_01_06_425584 684 1071 353.2061 353.2061 CD 10_1101-2021_01_06_425584 684 1072 480.164 480.164 CD 10_1101-2021_01_06_425584 684 1073 752.5133 752.5133 NNP 10_1101-2021_01_06_425584 684 1074 264.072 264.072 CD 10_1101-2021_01_06_425584 684 1075 488.3571 488.3571 CD 10_1101-2021_01_06_425584 684 1076 308.0629 308.0629 CD 10_1101-2021_01_06_425584 684 1077 130.1588 130.1588 NN 10_1101-2021_01_06_425584 684 1078 603.2672 603.2672 NNP 10_1101-2021_01_06_425584 684 1079 654.1961 654.1961 NNP 10_1101-2021_01_06_425584 684 1080 861.4975 861.4975 NNP 10_1101-2021_01_06_425584 684 1081 452.0319 452.0319 RB 10_1101-2021_01_06_425584 684 1082 293.1149 293.1149 CD 10_1101-2021_01_06_425584 684 1083 222.0541 222.0541 CD 10_1101-2021_01_06_425584 684 1084 266.173 266.173 CD 10_1101-2021_01_06_425584 684 1085 546.1593 546.1593 CD 10_1101-2021_01_06_425584 684 1086 481.2613 481.2613 CD 10_1101-2021_01_06_425584 684 1087 198.0459 198.0459 CD 10_1101-2021_01_06_425584 684 1088 773.4417 773.4417 NNP 10_1101-2021_01_06_425584 684 1089 297.2129 297.2129 CD 10_1101-2021_01_06_425584 684 1090 312.1869 312.1869 NNP 10_1101-2021_01_06_425584 684 1091 161.096 161.096 CD 10_1101-2021_01_06_425584 684 1092 357.0869 357.0869 NNP 10_1101-2021_01_06_425584 684 1093 302.148 302.148 CD 10_1101-2021_01_06_425584 684 1094 493.313 493.313 CD 10_1101-2021_01_06_425584 684 1095 532.3832 532.3832 JJ 10_1101-2021_01_06_425584 684 1096 373.3665 373.3665 UH 10_1101-2021_01_06_425584 684 1097 448.1767 448.1767 NN 10_1101-2021_01_06_425584 684 1098 287.1911 287.1911 NN 10_1101-2021_01_06_425584 684 1099 181.6125 181.6125 CD 10_1101-2021_01_06_425584 684 1100 845.5211 845.5211 NNP 10_1101-2021_01_06_425584 684 1101 335.0784 335.0784 NNP 10_1101-2021_01_06_425584 684 1102 289.1088 289.1088 CD 10_1101-2021_01_06_425584 684 1103 369.154 369.154 CD 10_1101-2021_01_06_425584 684 1104 288.1805 288.1805 NN 10_1101-2021_01_06_425584 684 1105 509.3542 509.3542 JJ 10_1101-2021_01_06_425584 684 1106 773.4915 773.4915 CD 10_1101-2021_01_06_425584 684 1107 641.3634 641.3634 CD 10_1101-2021_01_06_425584 684 1108 289.0603 289.0603 CD 10_1101-2021_01_06_425584 684 1109 277.1275 277.1275 CD 10_1101-2021_01_06_425584 684 1110 202.1436 202.1436 CD 10_1101-2021_01_06_425584 684 1111 320.2765 320.2765 NNP 10_1101-2021_01_06_425584 684 1112 604.3512 604.3512 NNP 10_1101-2021_01_06_425584 684 1113 355.0651 355.0651 NNP 10_1101-2021_01_06_425584 684 1114 445.1738 445.1738 NNP 10_1101-2021_01_06_425584 684 1115 561.3101 561.3101 NNP 10_1101-2021_01_06_425584 684 1116 304.2108 304.2108 NNP 10_1101-2021_01_06_425584 684 1117 439.2092 439.2092 NN 10_1101-2021_01_06_425584 684 1118 582.272 582.272 CD 10_1101-2021_01_06_425584 684 1119 380.1061 380.1061 CD 10_1101-2021_01_06_425584 684 1120 639.3729 639.3729 CD 10_1101-2021_01_06_425584 684 1121 521.1369 521.1369 NN 10_1101-2021_01_06_425584 684 1122 334.0761 334.0761 NN 10_1101-2021_01_06_425584 684 1123 593.2762 593.2762 NNP 10_1101-2021_01_06_425584 684 1124 324.1011 324.1011 CD 10_1101-2021_01_06_425584 684 1125 453.3427 453.3427 CD 10_1101-2021_01_06_425584 684 1126 335.1059 335.1059 NN 10_1101-2021_01_06_425584 684 1127 515.2178 515.2178 NNP 10_1101-2021_01_06_425584 684 1128 540.1005 540.1005 NNP 10_1101-2021_01_06_425584 684 1129 294.2273 294.2273 NNP 10_1101-2021_01_06_425584 684 1130 380.1122 380.1122 NN 10_1101-2021_01_06_425584 684 1131 246.0794 246.0794 MD 10_1101-2021_01_06_425584 684 1132 365.2676 365.2676 PRP 10_1101-2021_01_06_425584 684 1133 462.1453 462.1453 NN 10_1101-2021_01_06_425584 684 1134 376.2308 376.2308 NNP 10_1101-2021_01_06_425584 684 1135 204.045 204.045 CD 10_1101-2021_01_06_425584 684 1136 357.2989 357.2989 CD 10_1101-2021_01_06_425584 684 1137 268.0628 268.0628 CD 10_1101-2021_01_06_425584 684 1138 215.9822 215.9822 CD 10_1101-2021_01_06_425584 684 1139 725.3575 725.3575 NNP 10_1101-2021_01_06_425584 684 1140 530.1589 530.1589 NN 10_1101-2021_01_06_425584 684 1141 184.1328 184.1328 CD 10_1101-2021_01_06_425584 684 1142 338.0815 338.0815 NN 10_1101-2021_01_06_425584 684 1143 385.1971 385.1971 RB 10_1101-2021_01_06_425584 684 1144 268.1542 268.1542 CD 10_1101-2021_01_06_425584 684 1145 343.2955 343.2955 CD 10_1101-2021_01_06_425584 684 1146 645.3443 645.3443 NNP 10_1101-2021_01_06_425584 684 1147 283.0944 283.0944 JJ 10_1101-2021_01_06_425584 684 1148 559.3043 559.3043 NNS 10_1101-2021_01_06_425584 684 1149 462.248 462.248 CD 10_1101-2021_01_06_425584 684 1150 313.1461 313.1461 CD 10_1101-2021_01_06_425584 684 1151 477.3414 477.3414 CD 10_1101-2021_01_06_425584 684 1152 529.3357 529.3357 NN 10_1101-2021_01_06_425584 684 1153 609.3057 609.3057 NNP 10_1101-2021_01_06_425584 684 1154 373.1514 373.1514 NNP 10_1101-2021_01_06_425584 684 1155 405.2599 405.2599 NNP 10_1101-2021_01_06_425584 684 1156 545.1545 545.1545 XX 10_1101-2021_01_06_425584 684 1157 394.1956 394.1956 CD 10_1101-2021_01_06_425584 684 1158 385.1877 385.1877 NNP 10_1101-2021_01_06_425584 684 1159 423.1984 423.1984 CD 10_1101-2021_01_06_425584 684 1160 592.1777 592.1777 NNP 10_1101-2021_01_06_425584 684 1161 409.2473 409.2473 NNP 10_1101-2021_01_06_425584 684 1162 325.2274 325.2274 NN 10_1101-2021_01_06_425584 684 1163 276.0625 276.0625 CD 10_1101-2021_01_06_425584 684 1164 436.062 436.062 CD 10_1101-2021_01_06_425584 684 1165 320.1688 320.1688 NNP 10_1101-2021_01_06_425584 684 1166 228.1955 228.1955 CD 10_1101-2021_01_06_425584 684 1167 867.3655 867.3655 JJ 10_1101-2021_01_06_425584 684 1168 317.21 317.21 CD 10_1101-2021_01_06_425584 684 1169 344.2278 344.2278 CD 10_1101-2021_01_06_425584 684 1170 509.2845 509.2845 JJ 10_1101-2021_01_06_425584 684 1171 517.2837 517.2837 JJ 10_1101-2021_01_06_425584 684 1172 584.2047 584.2047 NN 10_1101-2021_01_06_425584 684 1173 328.9155 328.9155 CD 10_1101-2021_01_06_425584 684 1174 341.1805 341.1805 IN 10_1101-2021_01_06_425584 684 1175 434.0686 434.0686 CD 10_1101-2021_01_06_425584 684 1176 287.2105 287.2105 CD 10_1101-2021_01_06_425584 684 1177 242.1159 242.1159 CD 10_1101-2021_01_06_425584 684 1178 221.1114 221.1114 CD 10_1101-2021_01_06_425584 684 1179 575.2728 575.2728 RB 10_1101-2021_01_06_425584 684 1180 597.2364 597.2364 JJ 10_1101-2021_01_06_425584 684 1181 198.1485 198.1485 NN 10_1101-2021_01_06_425584 684 1182 362.3622 362.3622 NN 10_1101-2021_01_06_425584 684 1183 312.3253 312.3253 NNP 10_1101-2021_01_06_425584 684 1184 543.2987 543.2987 NN 10_1101-2021_01_06_425584 684 1185 345.3354 345.3354 NNP 10_1101-2021_01_06_425584 684 1186 315.2268 315.2268 NNP 10_1101-2021_01_06_425584 684 1187 713.3509 713.3509 NNP 10_1101-2021_01_06_425584 684 1188 478.0851 478.0851 NNP 10_1101-2021_01_06_425584 684 1189 357.2366 357.2366 CD 10_1101-2021_01_06_425584 684 1190 610.367 610.367 CD 10_1101-2021_01_06_425584 684 1191 264.0784 264.0784 CD 10_1101-2021_01_06_425584 684 1192 476.3052 476.3052 CD 10_1101-2021_01_06_425584 684 1193 340.0767 340.0767 CD 10_1101-2021_01_06_425584 684 1194 286.1397 286.1397 CD 10_1101-2021_01_06_425584 684 1195 636.4161 636.4161 CD 10_1101-2021_01_06_425584 684 1196 475.2773 475.2773 CD 10_1101-2021_01_06_425584 684 1197 652.1914 652.1914 NN 10_1101-2021_01_06_425584 684 1198 166.0861 166.0861 CD 10_1101-2021_01_06_425584 684 1199 675.5421 675.5421 NNP 10_1101-2021_01_06_425584 684 1200 546.1562 546.1562 NNP 10_1101-2021_01_06_425584 684 1201 271.181 271.181 CD 10_1101-2021_01_06_425584 684 1202 387.1935 387.1935 CD 10_1101-2021_01_06_425584 684 1203 192.1223 192.1223 CD 10_1101-2021_01_06_425584 684 1204 331.1899 331.1899 NN 10_1101-2021_01_06_425584 684 1205 351.1808 351.1808 NNP 10_1101-2021_01_06_425584 684 1206 507.2935 507.2935 NNP 10_1101-2021_01_06_425584 684 1207 637.3037 637.3037 IN 10_1101-2021_01_06_425584 684 1208 225.1095 225.1095 NN 10_1101-2021_01_06_425584 684 1209 560.3254 560.3254 NNP 10_1101-2021_01_06_425584 684 1210 631.3504 631.3504 IN 10_1101-2021_01_06_425584 684 1211 359.1477 359.1477 RB 10_1101-2021_01_06_425584 684 1212 269.0883 269.0883 CD 10_1101-2021_01_06_425584 684 1213 619.2691 619.2691 CD 10_1101-2021_01_06_425584 684 1214 164.1065 164.1065 CD 10_1101-2021_01_06_425584 684 1215 218.1383 218.1383 CD 10_1101-2021_01_06_425584 684 1216 283.1171 283.1171 CD 10_1101-2021_01_06_425584 684 1217 259.0201 259.0201 NN 10_1101-2021_01_06_425584 684 1218 434.2585 434.2585 CD 10_1101-2021_01_06_425584 684 1219 188.1999 188.1999 CD 10_1101-2021_01_06_425584 684 1220 385.2071 385.2071 NN 10_1101-2021_01_06_425584 684 1221 635.1389 635.1389 VB 10_1101-2021_01_06_425584 684 1222 493.2815 493.2815 IN 10_1101-2021_01_06_425584 684 1223 479.0776 479.0776 JJ 10_1101-2021_01_06_425584 684 1224 526.2914 526.2914 JJ 10_1101-2021_01_06_425584 684 1225 223.0963 223.0963 NN 10_1101-2021_01_06_425584 684 1226 429.3016 429.3016 RB 10_1101-2021_01_06_425584 684 1227 639.2251 639.2251 VB 10_1101-2021_01_06_425584 684 1228 534.3094 534.3094 RB 10_1101-2021_01_06_425584 684 1229 298.095 298.095 CD 10_1101-2021_01_06_425584 684 1230 486.226 486.226 CD 10_1101-2021_01_06_425584 684 1231 697.3627 697.3627 CD 10_1101-2021_01_06_425584 684 1232 513.3387 513.3387 NN 10_1101-2021_01_06_425584 684 1233 373.0739 373.0739 RB 10_1101-2021_01_06_425584 684 1234 277.0958 277.0958 CD 10_1101-2021_01_06_425584 684 1235 440.2142 440.2142 NNP 10_1101-2021_01_06_425584 684 1236 711.1232 711.1232 NNP 10_1101-2021_01_06_425584 684 1237 297.0668 297.0668 CD 10_1101-2021_01_06_425584 684 1238 285.0076 285.0076 NN 10_1101-2021_01_06_425584 684 1239 420.1996 420.1996 CD 10_1101-2021_01_06_425584 684 1240 246.0252 246.0252 NN 10_1101-2021_01_06_425584 684 1241 486.1428 486.1428 NN 10_1101-2021_01_06_425584 684 1242 516.2999 516.2999 NN 10_1101-2021_01_06_425584 684 1243 325.2119 325.2119 XX 10_1101-2021_01_06_425584 684 1244 455.2416 455.2416 CD 10_1101-2021_01_06_425584 684 1245 581.3643 581.3643 JJ 10_1101-2021_01_06_425584 684 1246 300.2164 300.2164 NNP 10_1101-2021_01_06_425584 684 1247 625.2127 625.2127 NNP 10_1101-2021_01_06_425584 684 1248 421.2334 421.2334 CD 10_1101-2021_01_06_425584 684 1249 241.5671 241.5671 CD 10_1101-2021_01_06_425584 684 1250 239.1269 239.1269 CD 10_1101-2021_01_06_425584 684 1251 301.0709 301.0709 NNP 10_1101-2021_01_06_425584 684 1252 384.1148 384.1148 NNP 10_1101-2021_01_06_425584 684 1253 381.2962 381.2962 NNP 10_1101-2021_01_06_425584 684 1254 299.1163 299.1163 NNP 10_1101-2021_01_06_425584 684 1255 829.4161 829.4161 NN 10_1101-2021_01_06_425584 684 1256 366.1317 366.1317 NNP 10_1101-2021_01_06_425584 684 1257 711.1342 711.1342 NNP 10_1101-2021_01_06_425584 684 1258 362.2528 362.2528 NNP 10_1101-2021_01_06_425584 684 1259 305.1569 305.1569 NNP 10_1101-2021_01_06_425584 684 1260 548.3632 548.3632 RB 10_1101-2021_01_06_425584 684 1261 263.125 263.125 CD 10_1101-2021_01_06_425584 684 1262 526.2574 526.2574 NNP 10_1101-2021_01_06_425584 684 1263 610.1959 610.1959 NNP 10_1101-2021_01_06_425584 684 1264 353.1168 353.1168 NNP 10_1101-2021_01_06_425584 684 1265 337.0808 337.0808 CD 10_1101-2021_01_06_425584 684 1266 580.1723 580.1723 NN 10_1101-2021_01_06_425584 684 1267 282.1469 282.1469 NNP 10_1101-2021_01_06_425584 684 1268 383.2029 383.2029 CD 10_1101-2021_01_06_425584 684 1269 699.612 699.612 CD 10_1101-2021_01_06_425584 684 1270 408.7552 408.7552 CD 10_1101-2021_01_06_425584 684 1271 166.0742 166.0742 CD 10_1101-2021_01_06_425584 684 1272 359.7141 359.7141 CD 10_1101-2021_01_06_425584 684 1273 218.1194 218.1194 NNP 10_1101-2021_01_06_425584 684 1274 283.1332 283.1332 NNP 10_1101-2021_01_06_425584 684 1275 696.4348 696.4348 VB 10_1101-2021_01_06_425584 684 1276 671.3179 671.3179 NNP 10_1101-2021_01_06_425584 684 1277 525.2874 525.2874 UH 10_1101-2021_01_06_425584 684 1278 553.3113 553.3113 IN 10_1101-2021_01_06_425584 684 1279 443.1129 443.1129 CD 10_1101-2021_01_06_425584 684 1280 332.2177 332.2177 CD 10_1101-2021_01_06_425584 684 1281 262.1188 262.1188 NNP 10_1101-2021_01_06_425584 684 1282 539.267 539.267 CD 10_1101-2021_01_06_425584 684 1283 437.2364 437.2364 JJ 10_1101-2021_01_06_425584 684 1284 184.9848 184.9848 CD 10_1101-2021_01_06_425584 684 1285 265.5857 265.5857 CD 10_1101-2021_01_06_425584 684 1286 343.1425 343.1425 CD 10_1101-2021_01_06_425584 684 1287 188.07 188.07 CD 10_1101-2021_01_06_425584 684 1288 292.096 292.096 CD 10_1101-2021_01_06_425584 684 1289 432.2794 432.2794 CD 10_1101-2021_01_06_425584 684 1290 368.1451 368.1451 CD 10_1101-2021_01_06_425584 684 1291 261.1094 261.1094 CD 10_1101-2021_01_06_425584 684 1292 456.2802 456.2802 NNP 10_1101-2021_01_06_425584 684 1293 Cluster Cluster NNP 10_1101-2021_01_06_425584 684 1294 1 1 CD 10_1101-2021_01_06_425584 684 1295 Cluster cluster NN 10_1101-2021_01_06_425584 684 1296 3 3 CD 10_1101-2021_01_06_425584 684 1297 Cluster cluster NN 10_1101-2021_01_06_425584 684 1298 2 2 CD 10_1101-2021_01_06_425584 684 1299 A a DT 10_1101-2021_01_06_425584 684 1300 C c NN 10_1101-2021_01_06_425584 684 1301 MS2LDA ms2lda NN 10_1101-2021_01_06_425584 684 1302 760.5815 760.5815 CD 10_1101-2021_01_06_425584 684 1303 m m NN 10_1101-2021_01_06_425584 684 1304 / / SYM 10_1101-2021_01_06_425584 684 1305 z z NN 10_1101-2021_01_06_425584 684 1306 * * NFP 10_1101-2021_01_06_425584 684 1307 B b NN 10_1101-2021_01_06_425584 684 1308 M2M_526_Phosphocholine m2m_526_phosphocholine NN 10_1101-2021_01_06_425584 684 1309 - - HYPH 10_1101-2021_01_06_425584 684 1310 based base VBN 10_1101-2021_01_06_425584 684 1311 substructure substructure NN 10_1101-2021_01_06_425584 684 1312 0 0 CD 10_1101-2021_01_06_425584 684 1313 100 100 CD 10_1101-2021_01_06_425584 684 1314 200 200 CD 10_1101-2021_01_06_425584 684 1315 300 300 CD 10_1101-2021_01_06_425584 684 1316 400 400 CD 10_1101-2021_01_06_425584 684 1317 0 0 CD 10_1101-2021_01_06_425584 684 1318 25 25 CD 10_1101-2021_01_06_425584 684 1319 50 50 CD 10_1101-2021_01_06_425584 684 1320 75 75 CD 10_1101-2021_01_06_425584 684 1321 100 100 CD 10_1101-2021_01_06_425584 684 1322 m m NN 10_1101-2021_01_06_425584 684 1323 / / SYM 10_1101-2021_01_06_425584 684 1324 z z NNP 10_1101-2021_01_06_425584 684 1325 R R NNP 10_1101-2021_01_06_425584 684 1326 el el NNP 10_1101-2021_01_06_425584 684 1327 at at IN 10_1101-2021_01_06_425584 684 1328 iv iv NNP 10_1101-2021_01_06_425584 684 1329 e e NNP 10_1101-2021_01_06_425584 684 1330 In in IN 10_1101-2021_01_06_425584 684 1331 te te NNP 10_1101-2021_01_06_425584 684 1332 ns ns IN 10_1101-2021_01_06_425584 684 1333 ity ity NNP 10_1101-2021_01_06_425584 684 1334 184.0725 184.0725 NNP 10_1101-2021_01_06_425584 684 1335 OH OH NNP 10_1101-2021_01_06_425584 684 1336 P p NN 10_1101-2021_01_06_425584 684 1337 O o NN 10_1101-2021_01_06_425584 684 1338 OHO oho NN 10_1101-2021_01_06_425584 684 1339 N+ N+ VBN 10_1101-2021_01_06_425584 684 1340 Lo Lo NNP 10_1101-2021_01_06_425584 684 1341 g2 g2 NNP 10_1101-2021_01_06_425584 684 1342 F F NNP 10_1101-2021_01_06_425584 684 1343 C C NNP 10_1101-2021_01_06_425584 684 1344 3.6 3.6 CD 10_1101-2021_01_06_425584 684 1345 -2.6 -2.6 CD 10_1101-2021_01_06_425584 684 1346 1 1 CD 10_1101-2021_01_06_425584 684 1347 Peptide peptide NN 10_1101-2021_01_06_425584 684 1348 metabolites metabolite NNS 10_1101-2021_01_06_425584 684 1349 C C NNP 10_1101-2021_01_06_425584 684 1350 A a NN 10_1101-2021_01_06_425584 684 1351 162.0225 162.0225 JJ 10_1101-2021_01_06_425584 684 1352 m m NN 10_1101-2021_01_06_425584 684 1353 / / SYM 10_1101-2021_01_06_425584 684 1354 z z NNP 10_1101-2021_01_06_425584 684 1355 M2M_453_Glutathione M2M_453_Glutathione NNP 10_1101-2021_01_06_425584 684 1356 - - HYPH 10_1101-2021_01_06_425584 684 1357 based base VBN 10_1101-2021_01_06_425584 684 1358 substructure substructure NN 10_1101-2021_01_06_425584 684 1359 H h NN 10_1101-2021_01_06_425584 684 1360 + + CC 10_1101-2021_01_06_425584 684 1361 308.0911 308.0911 CD 10_1101-2021_01_06_425584 684 1362 m m NN 10_1101-2021_01_06_425584 684 1363 / / SYM 10_1101-2021_01_06_425584 684 1364 z z NN 10_1101-2021_01_06_425584 684 1365 OH oh NN 10_1101-2021_01_06_425584 684 1366 H h NN 10_1101-2021_01_06_425584 684 1367 N n NN 10_1101-2021_01_06_425584 684 1368 OH oh NN 10_1101-2021_01_06_425584 684 1369 O o UH 10_1101-2021_01_06_425584 684 1370 SH sh NN 10_1101-2021_01_06_425584 684 1371 H2N h2n NN 10_1101-2021_01_06_425584 684 1372 O o NN 10_1101-2021_01_06_425584 684 1373 H h NN 10_1101-2021_01_06_425584 684 1374 N n NN 10_1101-2021_01_06_425584 684 1375 OH oh NN 10_1101-2021_01_06_425584 684 1376 O o UH 10_1101-2021_01_06_425584 684 1377 SH SH NNP 10_1101-2021_01_06_425584 684 1378 N n NN 10_1101-2021_01_06_425584 684 1379 H H NNP 10_1101-2021_01_06_425584 684 1380 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1381 HO HO NNP 10_1101-2021_01_06_425584 684 1382 O o NN 10_1101-2021_01_06_425584 684 1383 O o NN 10_1101-2021_01_06_425584 684 1384 O o NN 10_1101-2021_01_06_425584 684 1385 H2 h2 NN 10_1101-2021_01_06_425584 684 1386 N n NN 10_1101-2021_01_06_425584 684 1387 OH oh NN 10_1101-2021_01_06_425584 684 1388 O o UH 10_1101-2021_01_06_425584 684 1389 SH sh NN 10_1101-2021_01_06_425584 684 1390 O o NN 10_1101-2021_01_06_425584 684 1391 H h NN 10_1101-2021_01_06_425584 684 1392 N n NN 10_1101-2021_01_06_425584 684 1393 OH oh NN 10_1101-2021_01_06_425584 684 1394 O o UH 10_1101-2021_01_06_425584 684 1395 SH sh NN 10_1101-2021_01_06_425584 684 1396 N n NN 10_1101-2021_01_06_425584 684 1397 H h NN 10_1101-2021_01_06_425584 684 1398 O o NN 10_1101-2021_01_06_425584 684 1399 233.059 233.059 CD 10_1101-2021_01_06_425584 684 1400 m m NN 10_1101-2021_01_06_425584 684 1401 / / SYM 10_1101-2021_01_06_425584 684 1402 z z NNP 10_1101-2021_01_06_425584 684 1403 162.0219 162.0219 CD 10_1101-2021_01_06_425584 684 1404 m m NNP 10_1101-2021_01_06_425584 684 1405 / / SYM 10_1101-2021_01_06_425584 684 1406 z z NNP 10_1101-2021_01_06_425584 684 1407 179.0484 179.0484 CD 10_1101-2021_01_06_425584 684 1408 m m NNP 10_1101-2021_01_06_425584 684 1409 / / SYM 10_1101-2021_01_06_425584 684 1410 z z NNP 10_1101-2021_01_06_425584 684 1411 M2M_59_Phenylalanine M2M_59_Phenylalanine NNP 10_1101-2021_01_06_425584 684 1412 - - HYPH 10_1101-2021_01_06_425584 684 1413 based base VBN 10_1101-2021_01_06_425584 684 1414 substructure substructure NN 10_1101-2021_01_06_425584 684 1415 166.0875 166.0875 CD 10_1101-2021_01_06_425584 684 1416 m m NN 10_1101-2021_01_06_425584 684 1417 / / SYM 10_1101-2021_01_06_425584 684 1418 z z NNP 10_1101-2021_01_06_425584 684 1419 166.0875 166.0875 CD 10_1101-2021_01_06_425584 684 1420 m m NNP 10_1101-2021_01_06_425584 684 1421 / / SYM 10_1101-2021_01_06_425584 684 1422 z z NNP 10_1101-2021_01_06_425584 684 1423 166.0875 166.0875 CD 10_1101-2021_01_06_425584 684 1424 m m NNP 10_1101-2021_01_06_425584 684 1425 / / SYM 10_1101-2021_01_06_425584 684 1426 z z NNP 10_1101-2021_01_06_425584 684 1427 166.0875 166.0875 CD 10_1101-2021_01_06_425584 684 1428 m m NNP 10_1101-2021_01_06_425584 684 1429 / / SYM 10_1101-2021_01_06_425584 684 1430 z z NNP 10_1101-2021_01_06_425584 684 1431 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1432 OH OH NNP 10_1101-2021_01_06_425584 684 1433 OH OH NNP 10_1101-2021_01_06_425584 684 1434 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1435 120.0825 120.0825 CD 10_1101-2021_01_06_425584 684 1436 m m NNP 10_1101-2021_01_06_425584 684 1437 / / SYM 10_1101-2021_01_06_425584 684 1438 z z NNP 10_1101-2021_01_06_425584 684 1439 120.0825 120.0825 CD 10_1101-2021_01_06_425584 684 1440 m m NNP 10_1101-2021_01_06_425584 684 1441 / / SYM 10_1101-2021_01_06_425584 684 1442 z z NNP 10_1101-2021_01_06_425584 684 1443 120.0825 120.0825 CD 10_1101-2021_01_06_425584 684 1444 m m NNP 10_1101-2021_01_06_425584 684 1445 / / SYM 10_1101-2021_01_06_425584 684 1446 z z NNP 10_1101-2021_01_06_425584 684 1447 120.0825 120.0825 CD 10_1101-2021_01_06_425584 684 1448 m m NN 10_1101-2021_01_06_425584 684 1449 / / SYM 10_1101-2021_01_06_425584 684 1450 z z NNP 10_1101-2021_01_06_425584 684 1451 [ [ -LRB- 10_1101-2021_01_06_425584 684 1452 M+H]+ M+H]+ NNP 10_1101-2021_01_06_425584 684 1453 [ [ -LRB- 10_1101-2021_01_06_425584 684 1454 M+H]+ M+H]+ NNP 10_1101-2021_01_06_425584 684 1455 MS2LDA ms2lda NN 10_1101-2021_01_06_425584 684 1456 M2M_453 m2m_453 NN 10_1101-2021_01_06_425584 684 1457 B b NN 10_1101-2021_01_06_425584 684 1458 * * NFP 10_1101-2021_01_06_425584 684 1459 615.1719 615.1719 CD 10_1101-2021_01_06_425584 684 1460 m m NN 10_1101-2021_01_06_425584 684 1461 / / SYM 10_1101-2021_01_06_425584 684 1462 z z NNP 10_1101-2021_01_06_425584 684 1463 D D NNP 10_1101-2021_01_06_425584 684 1464 MS2LDA ms2lda NN 10_1101-2021_01_06_425584 684 1465 M2M_59 M2M_59 NNP 10_1101-2021_01_06_425584 684 1466 * * NFP 10_1101-2021_01_06_425584 684 1467 297.1802 297.1802 CD 10_1101-2021_01_06_425584 684 1468 m m NNP 10_1101-2021_01_06_425584 684 1469 / / SYM 10_1101-2021_01_06_425584 684 1470 z z NNP 10_1101-2021_01_06_425584 684 1471 487.1548 487.1548 CD 10_1101-2021_01_06_425584 684 1472 m m NNP 10_1101-2021_01_06_425584 684 1473 / / SYM 10_1101-2021_01_06_425584 684 1474 z z NN 10_1101-2021_01_06_425584 684 1475 * * NFP 10_1101-2021_01_06_425584 684 1476 * * NFP 10_1101-2021_01_06_425584 684 1477 295.1285 295.1285 CD 10_1101-2021_01_06_425584 684 1478 m m NN 10_1101-2021_01_06_425584 684 1479 / / SYM 10_1101-2021_01_06_425584 684 1480 z z NNP 10_1101-2021_01_06_425584 684 1481 277.1856 277.1856 CD 10_1101-2021_01_06_425584 684 1482 382.2582 382.2582 NN 10_1101-2021_01_06_425584 684 1483 382.527 382.527 CD 10_1101-2021_01_06_425584 684 1484 371.1907 371.1907 NNP 10_1101-2021_01_06_425584 684 1485 371.0673 371.0673 NNP 10_1101-2021_01_06_425584 684 1486 306.2272 306.2272 NNP 10_1101-2021_01_06_425584 684 1487 230.1749 230.1749 NNP 10_1101-2021_01_06_425584 684 1488 442.8012 442.8012 NN 10_1101-2021_01_06_425584 684 1489 509.1202 509.1202 NNP 10_1101-2021_01_06_425584 684 1490 403.1745 403.1745 CD 10_1101-2021_01_06_425584 684 1491 244.2086 244.2086 CD 10_1101-2021_01_06_425584 684 1492 385.2079 385.2079 NNP 10_1101-2021_01_06_425584 684 1493 358.2426 358.2426 NNP 10_1101-2021_01_06_425584 684 1494 477.2296 477.2296 CD 10_1101-2021_01_06_425584 684 1495 371.0477 371.0477 NNP 10_1101-2021_01_06_425584 684 1496 331.1573 331.1573 NNP 10_1101-2021_01_06_425584 684 1497 190.1434 190.1434 NNP 10_1101-2021_01_06_425584 684 1498 295.1285 295.1285 NNP 10_1101-2021_01_06_425584 684 1499 461.2096 461.2096 NNP 10_1101-2021_01_06_425584 684 1500 347.1596 347.1596 NNP 10_1101-2021_01_06_425584 684 1501 329.1818 329.1818 NNP 10_1101-2021_01_06_425584 684 1502 371.2276 371.2276 NNP 10_1101-2021_01_06_425584 684 1503 216.1954 216.1954 NNP 10_1101-2021_01_06_425584 684 1504 318.1811 318.1811 NNP 10_1101-2021_01_06_425584 684 1505 348.2378 348.2378 NNP 10_1101-2021_01_06_425584 684 1506 477.2335 477.2335 NNP 10_1101-2021_01_06_425584 684 1507 208.1812 208.1812 NNP 10_1101-2021_01_06_425584 684 1508 297.1802 297.1802 NNP 10_1101-2021_01_06_425584 684 1509 355.1755 355.1755 NNP 10_1101-2021_01_06_425584 684 1510 331.1648 331.1648 NNP 10_1101-2021_01_06_425584 684 1511 261.1445 261.1445 CD 10_1101-2021_01_06_425584 684 1512 331.1366 331.1366 CD 10_1101-2021_01_06_425584 684 1513 295.1349 295.1349 CD 10_1101-2021_01_06_425584 684 1514 257.2212 257.2212 CD 10_1101-2021_01_06_425584 684 1515 331.1695 331.1695 NNP 10_1101-2021_01_06_425584 684 1516 264.072 264.072 CD 10_1101-2021_01_06_425584 684 1517 302.148 302.148 CD 10_1101-2021_01_06_425584 684 1518 509.3542 509.3542 JJ 10_1101-2021_01_06_425584 684 1519 202.1436 202.1436 CD 10_1101-2021_01_06_425584 684 1520 334.0761 334.0761 NN 10_1101-2021_01_06_425584 684 1521 313.1461 313.1461 CD 10_1101-2021_01_06_425584 684 1522 320.1688 320.1688 NN 10_1101-2021_01_06_425584 684 1523 188.1999 188.1999 NN 10_1101-2021_01_06_425584 684 1524 610.1959 610.1959 VBD 10_1101-2021_01_06_425584 684 1525 261.1094 261.1094 CD 10_1101-2021_01_06_425584 684 1526 N n NN 10_1101-2021_01_06_425584 684 1527 H h NN 10_1101-2021_01_06_425584 684 1528 O o NN 10_1101-2021_01_06_425584 684 1529 OH oh NN 10_1101-2021_01_06_425584 684 1530 O o UH 10_1101-2021_01_06_425584 684 1531 HO HO NNP 10_1101-2021_01_06_425584 684 1532 O o NN 10_1101-2021_01_06_425584 684 1533 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1534 Glutamyl Glutamyl NNP 10_1101-2021_01_06_425584 684 1535 - - HYPH 10_1101-2021_01_06_425584 684 1536 phenylalanine phenylalanine NNP 10_1101-2021_01_06_425584 684 1537 [ [ -LRB- 10_1101-2021_01_06_425584 684 1538 M+H]+ M+H]+ NNP 10_1101-2021_01_06_425584 684 1539 Unknown unknown JJ 10_1101-2021_01_06_425584 684 1540 118.086 118.086 CD 10_1101-2021_01_06_425584 684 1541 481.2106 481.2106 CD 10_1101-2021_01_06_425584 684 1542 386.3258 386.3258 CD 10_1101-2021_01_06_425584 684 1543 615.1719 615.1719 CD 10_1101-2021_01_06_425584 684 1544 409.2795 409.2795 NNP 10_1101-2021_01_06_425584 684 1545 217.1478 217.1478 NNP 10_1101-2021_01_06_425584 684 1546 490.1759 490.1759 CD 10_1101-2021_01_06_425584 684 1547 629.159 629.159 CD 10_1101-2021_01_06_425584 684 1548 358.1104 358.1104 NNP 10_1101-2021_01_06_425584 684 1549 398.2412 398.2412 NN 10_1101-2021_01_06_425584 684 1550 313.2128 313.2128 JJ 10_1101-2021_01_06_425584 684 1551 197.116 197.116 CD 10_1101-2021_01_06_425584 684 1552 242.116 242.116 CD 10_1101-2021_01_06_425584 684 1553 299.199 299.199 CD 10_1101-2021_01_06_425584 684 1554 713.1472 713.1472 CD 10_1101-2021_01_06_425584 684 1555 502.0925 502.0925 NNP 10_1101-2021_01_06_425584 684 1556 508.3023 508.3023 NNP 10_1101-2021_01_06_425584 684 1557 679.4094 679.4094 NNP 10_1101-2021_01_06_425584 684 1558 409.1622 409.1622 CD 10_1101-2021_01_06_425584 684 1559 716.5212 716.5212 NNP 10_1101-2021_01_06_425584 684 1560 197.0779 197.0779 CD 10_1101-2021_01_06_425584 684 1561 338.1339 338.1339 VBZ 10_1101-2021_01_06_425584 684 1562 246.1016 246.1016 NNP 10_1101-2021_01_06_425584 684 1563 210.0494 210.0494 NNP 10_1101-2021_01_06_425584 684 1564 242.1172 242.1172 CD 10_1101-2021_01_06_425584 684 1565 291.1928 291.1928 CD 10_1101-2021_01_06_425584 684 1566 637.1514 637.1514 CD 10_1101-2021_01_06_425584 684 1567 311.1988 311.1988 NNP 10_1101-2021_01_06_425584 684 1568 256.0605 256.0605 NN 10_1101-2021_01_06_425584 684 1569 294.2061 294.2061 IN 10_1101-2021_01_06_425584 684 1570 307.5846 307.5846 NN 10_1101-2021_01_06_425584 684 1571 285.1892 285.1892 CD 10_1101-2021_01_06_425584 684 1572 421.3172 421.3172 CD 10_1101-2021_01_06_425584 684 1573 305.2105 305.2105 CD 10_1101-2021_01_06_425584 684 1574 308.8983 308.8983 CD 10_1101-2021_01_06_425584 684 1575 307.5897 307.5897 NNP 10_1101-2021_01_06_425584 684 1576 321.0536 321.0536 NN 10_1101-2021_01_06_425584 684 1577 308.0629 308.0629 NNP 10_1101-2021_01_06_425584 684 1578 222.0541 222.0541 CD 10_1101-2021_01_06_425584 684 1579 266.173 266.173 CD 10_1101-2021_01_06_425584 684 1580 277.1275 277.1275 CD 10_1101-2021_01_06_425584 684 1581 268.1542 268.1542 CD 10_1101-2021_01_06_425584 684 1582 343.2955 343.2955 CD 10_1101-2021_01_06_425584 684 1583 242.1159 242.1159 CD 10_1101-2021_01_06_425584 684 1584 513.3387 513.3387 NNP 10_1101-2021_01_06_425584 684 1585 277.0958 277.0958 CD 10_1101-2021_01_06_425584 684 1586 301.0709 301.0709 NNP 10_1101-2021_01_06_425584 684 1587 526.2574 526.2574 NNP 10_1101-2021_01_06_425584 684 1588 580.1723 580.1723 NNP 10_1101-2021_01_06_425584 684 1589 359.7141 359.7141 CD 10_1101-2021_01_06_425584 684 1590 283.1332 283.1332 CD 10_1101-2021_01_06_425584 684 1591 265.5857 265.5857 CD 10_1101-2021_01_06_425584 684 1592 * * NFP 10_1101-2021_01_06_425584 684 1593 308.0925 308.0925 NNP 10_1101-2021_01_06_425584 684 1594 m m NNP 10_1101-2021_01_06_425584 684 1595 / / SYM 10_1101-2021_01_06_425584 684 1596 z z NNP 10_1101-2021_01_06_425584 684 1597 179.0475 179.0475 NNP 10_1101-2021_01_06_425584 684 1598 m m NNP 10_1101-2021_01_06_425584 684 1599 / / SYM 10_1101-2021_01_06_425584 684 1600 z z NNP 10_1101-2021_01_06_425584 684 1601 233.0575 233.0575 CD 10_1101-2021_01_06_425584 684 1602 m m NNP 10_1101-2021_01_06_425584 684 1603 / / SYM 10_1101-2021_01_06_425584 684 1604 z z NNP 10_1101-2021_01_06_425584 684 1605 162.0225 162.0225 NNP 10_1101-2021_01_06_425584 684 1606 m m NNP 10_1101-2021_01_06_425584 684 1607 / / SYM 10_1101-2021_01_06_425584 684 1608 z z NNP 10_1101-2021_01_06_425584 684 1609 179.0475 179.0475 NNP 10_1101-2021_01_06_425584 684 1610 m m NNP 10_1101-2021_01_06_425584 684 1611 / / SYM 10_1101-2021_01_06_425584 684 1612 z z NNP 10_1101-2021_01_06_425584 684 1613 308.0925 308.0925 NNP 10_1101-2021_01_06_425584 684 1614 m m NNP 10_1101-2021_01_06_425584 684 1615 / / SYM 10_1101-2021_01_06_425584 684 1616 z z NNP 10_1101-2021_01_06_425584 684 1617 308.0925 308.0925 NNP 10_1101-2021_01_06_425584 684 1618 m m NNP 10_1101-2021_01_06_425584 684 1619 / / SYM 10_1101-2021_01_06_425584 684 1620 z z NNP 10_1101-2021_01_06_425584 684 1621 179.0475 179.0475 NNP 10_1101-2021_01_06_425584 684 1622 m m NNP 10_1101-2021_01_06_425584 684 1623 / / SYM 10_1101-2021_01_06_425584 684 1624 z z NNP 10_1101-2021_01_06_425584 684 1625 Precursor Precursor NNP 10_1101-2021_01_06_425584 684 1626 ion ion NN 10_1101-2021_01_06_425584 684 1627 629.159 629.159 CD 10_1101-2021_01_06_425584 684 1628 m m NNP 10_1101-2021_01_06_425584 684 1629 /z /z NNP 10_1101-2021_01_06_425584 684 1630 Precursor Precursor NNP 10_1101-2021_01_06_425584 684 1631 ion ion NN 10_1101-2021_01_06_425584 684 1632 713.1472 713.1472 NNP 10_1101-2021_01_06_425584 684 1633 m m NNP 10_1101-2021_01_06_425584 684 1634 /z /z NNP 10_1101-2021_01_06_425584 684 1635 Precursor Precursor NNP 10_1101-2021_01_06_425584 684 1636 ion ion NN 10_1101-2021_01_06_425584 684 1637 615.1719 615.1719 NN 10_1101-2021_01_06_425584 684 1638 m m NN 10_1101-2021_01_06_425584 684 1639 /z /z . 10_1101-2021_01_06_425584 684 1640 [ [ -LRB- 10_1101-2021_01_06_425584 684 1641 M+H]+ M+H]+ NNP 10_1101-2021_01_06_425584 684 1642 * * NFP 10_1101-2021_01_06_425584 684 1643 [ [ -LRB- 10_1101-2021_01_06_425584 684 1644 M+H]+ M+H]+ NNP 10_1101-2021_01_06_425584 684 1645 535.21233.0772 535.21233.0772 CD 10_1101-2021_01_06_425584 684 1646 487.1548 487.1548 CD 10_1101-2021_01_06_425584 684 1647 Unknown unknown JJ 10_1101-2021_01_06_425584 684 1648 * * NFP 10_1101-2021_01_06_425584 684 1649 * * NFP 10_1101-2021_01_06_425584 684 1650 [ [ -LRB- 10_1101-2021_01_06_425584 684 1651 2M+H]+ 2m+h]+ CD 10_1101-2021_01_06_425584 684 1652 Lo Lo NNP 10_1101-2021_01_06_425584 684 1653 g2 g2 NNP 10_1101-2021_01_06_425584 684 1654 F F NNP 10_1101-2021_01_06_425584 684 1655 C C NNP 10_1101-2021_01_06_425584 684 1656 -0.8 -0.8 : 10_1101-2021_01_06_425584 684 1657 3.1 3.1 CD 10_1101-2021_01_06_425584 684 1658 0 0 CD 10_1101-2021_01_06_425584 684 1659 Lo Lo NNP 10_1101-2021_01_06_425584 684 1660 g2 g2 NNP 10_1101-2021_01_06_425584 684 1661 F F NNP 10_1101-2021_01_06_425584 684 1662 C C NNP 10_1101-2021_01_06_425584 684 1663 -1.1 -1.1 . 10_1101-2021_01_06_425584 684 1664 1.3 1.3 CD 10_1101-2021_01_06_425584 684 1665 0 0 CD 10_1101-2021_01_06_425584 684 1666 Interacting interact VBG 10_1101-2021_01_06_425584 684 1667 protein protein NN 10_1101-2021_01_06_425584 684 1668 Seed seed NN 10_1101-2021_01_06_425584 684 1669 / / SYM 10_1101-2021_01_06_425584 684 1670 input input NN 10_1101-2021_01_06_425584 684 1671 protein protein NN 10_1101-2021_01_06_425584 684 1672 Connectivity connectivity NN 10_1101-2021_01_06_425584 684 1673 E e NN 10_1101-2021_01_06_425584 684 1674 B B NNP 10_1101-2021_01_06_425584 684 1675 n=32n=33 n=32n=33 NNP 10_1101-2021_01_06_425584 684 1676 A A NNP 10_1101-2021_01_06_425584 684 1677 Protein protein NN 10_1101-2021_01_06_425584 684 1678 - - HYPH 10_1101-2021_01_06_425584 684 1679 protein protein NN 10_1101-2021_01_06_425584 684 1680 interaction interaction NN 10_1101-2021_01_06_425584 684 1681 network network NN 10_1101-2021_01_06_425584 684 1682 symbology symbology NN 10_1101-2021_01_06_425584 684 1683 Mitochondrial Mitochondrial NNP 10_1101-2021_01_06_425584 684 1684 function function NN 10_1101-2021_01_06_425584 684 1685 PSMD3 PSMD3 . 10_1101-2021_01_06_425584 684 1686 PSMA4 PSMA4 '' 10_1101-2021_01_06_425584 684 1687 RPS13 RPS13 NNP 10_1101-2021_01_06_425584 684 1688 RPL9 RPL9 NNP 10_1101-2021_01_06_425584 684 1689 RPS7 RPS7 NNP 10_1101-2021_01_06_425584 684 1690 MCM3 MCM3 NNP 10_1101-2021_01_06_425584 684 1691 PPP2R2B PPP2R2B NNP 10_1101-2021_01_06_425584 684 1692 YWHAQ YWHAQ NNP 10_1101-2021_01_06_425584 684 1693 UBE2N ube2n JJ 10_1101-2021_01_06_425584 684 1694 PRMT5 PRMT5 NNS 10_1101-2021_01_06_425584 684 1695 PRDX2 PRDX2 NNS 10_1101-2021_01_06_425584 684 1696 PRDX6 prdx6 NN 10_1101-2021_01_06_425584 684 1697 COPG1 COPG1 NNP 10_1101-2021_01_06_425584 684 1698 DNA DNA NNP 10_1101-2021_01_06_425584 684 1699 / / SYM 10_1101-2021_01_06_425584 684 1700 RNA RNA NNP 10_1101-2021_01_06_425584 684 1701 metabolism metabolism NN 10_1101-2021_01_06_425584 684 1702 APRT APRT NNP 10_1101-2021_01_06_425584 684 1703 DDX1 DDX1 NNP 10_1101-2021_01_06_425584 684 1704 FIS1 FIS1 NNP 10_1101-2021_01_06_425584 684 1705 MX1 MX1 NNP 10_1101-2021_01_06_425584 684 1706 H2AFV H2AFV NNP 10_1101-2021_01_06_425584 684 1707 DHX9 DHX9 NNP 10_1101-2021_01_06_425584 684 1708 CAV1 CAV1 NNP 10_1101-2021_01_06_425584 684 1709 APEX1 apex1 NN 10_1101-2021_01_06_425584 684 1710 DYNLL1 dynll1 VBP 10_1101-2021_01_06_425584 684 1711 MYH10 MYH10 NNP 10_1101-2021_01_06_425584 684 1712 RDX rdx NN 10_1101-2021_01_06_425584 684 1713 YWHAB YWHAB NNP 10_1101-2021_01_06_425584 684 1714 GABARAPL2 gabarapl2 JJ 10_1101-2021_01_06_425584 684 1715 RPL18A rpl18a NN 10_1101-2021_01_06_425584 684 1716 COX4I1 COX4I1 : 10_1101-2021_01_06_425584 684 1717 UQCRC1 uqcrc1 NN 10_1101-2021_01_06_425584 684 1718 CTGF CTGF NNP 10_1101-2021_01_06_425584 684 1719 LAMP1 LAMP1 VBZ 10_1101-2021_01_06_425584 684 1720 CPSF6 CPSF6 NNP 10_1101-2021_01_06_425584 684 1721 B2 b2 NN 10_1101-2021_01_06_425584 684 1722 M M NNP 10_1101-2021_01_06_425584 684 1723 PDIA4 pdia4 NN 10_1101-2021_01_06_425584 684 1724 D d NN 10_1101-2021_01_06_425584 684 1725 C c NN 10_1101-2021_01_06_425584 684 1726 N n NN 10_1101-2021_01_06_425584 684 1727 orm orm NN 10_1101-2021_01_06_425584 684 1728 alized alize VBN 10_1101-2021_01_06_425584 684 1729 protein protein NN 10_1101-2021_01_06_425584 684 1730 abundance abundance NN 10_1101-2021_01_06_425584 684 1731 Protein Protein NNP 10_1101-2021_01_06_425584 684 1732 metabolism-20 metabolism-20 NN 10_1101-2021_01_06_425584 684 1733 -10 -10 NNP 10_1101-2021_01_06_425584 684 1734 0 0 CD 10_1101-2021_01_06_425584 684 1735 10 10 CD 10_1101-2021_01_06_425584 684 1736 20 20 CD 10_1101-2021_01_06_425584 684 1737 -4 -4 SYM 10_1101-2021_01_06_425584 684 1738 0 0 NFP 10_1101-2021_01_06_425584 684 1739 -2 -2 NFP 10_1101-2021_01_06_425584 684 1740 0 0 CD 10_1101-2021_01_06_425584 684 1741 0 0 CD 10_1101-2021_01_06_425584 684 1742 20 20 CD 10_1101-2021_01_06_425584 684 1743 40 40 CD 10_1101-2021_01_06_425584 684 1744 Scores Scores NNPS 10_1101-2021_01_06_425584 684 1745 Plot Plot NNP 10_1101-2021_01_06_425584 684 1746 PC pc NN 10_1101-2021_01_06_425584 684 1747 4 4 CD 10_1101-2021_01_06_425584 684 1748 ( ( -LRB- 10_1101-2021_01_06_425584 684 1749 14.8 14.8 CD 10_1101-2021_01_06_425584 684 1750 % % NN 10_1101-2021_01_06_425584 684 1751 ) ) -RRB- 10_1101-2021_01_06_425584 684 1752 P p NN 10_1101-2021_01_06_425584 684 1753 C c NN 10_1101-2021_01_06_425584 684 1754 1 1 CD 10_1101-2021_01_06_425584 684 1755 ( ( -LRB- 10_1101-2021_01_06_425584 684 1756 36 36 CD 10_1101-2021_01_06_425584 684 1757 .6 .6 CD 10_1101-2021_01_06_425584 684 1758 % % NN 10_1101-2021_01_06_425584 684 1759 ) ) -RRB- 10_1101-2021_01_06_425584 684 1760 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 684 1761 NG NG NNP 10_1101-2021_01_06_425584 684 1762 PC4 PC4 NNP 10_1101-2021_01_06_425584 684 1763 P P NNP 10_1101-2021_01_06_425584 684 1764 C c NN 10_1101-2021_01_06_425584 684 1765 1 1 CD 10_1101-2021_01_06_425584 684 1766 NG NG NNP 10_1101-2021_01_06_425584 684 1767 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 684 1768 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 684 1769 NG NG NNP 10_1101-2021_01_06_425584 684 1770 PRDX6 prdx6 NN 10_1101-2021_01_06_425584 684 1771 TXN2 txn2 VBP 10_1101-2021_01_06_425584 684 1772 APRT APRT NNP 10_1101-2021_01_06_425584 684 1773 Metabolites Metabolites NNP 10_1101-2021_01_06_425584 684 1774 Proteins Proteins NNPS 10_1101-2021_01_06_425584 684 1775 PRDX2 PRDX2 NNS 10_1101-2021_01_06_425584 684 1776 Glutamate Glutamate NNP 10_1101-2021_01_06_425584 684 1777 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 684 1778 Proline Proline NNP 10_1101-2021_01_06_425584 684 1779 Leucine Leucine NNP 10_1101-2021_01_06_425584 684 1780 Tyrosine Tyrosine NNP 10_1101-2021_01_06_425584 684 1781 2-AminoadipateKynurenine 2-aminoadipatekynurenine CD 10_1101-2021_01_06_425584 684 1782 Serine Serine NNP 10_1101-2021_01_06_425584 684 1783 Methionine Methionine NNP 10_1101-2021_01_06_425584 684 1784 Threonine Threonine NNP 10_1101-2021_01_06_425584 684 1785 OAT OAT NNP 10_1101-2021_01_06_425584 684 1786 HG+HING HG+HING NNP 10_1101-2021_01_06_425584 684 1787 Nuclei Nuclei NNP 10_1101-2021_01_06_425584 684 1788 vWF vWF VBD 10_1101-2021_01_06_425584 684 1789 Nuclei Nuclei NNP 10_1101-2021_01_06_425584 684 1790 vWF vwf IN 10_1101-2021_01_06_425584 684 1791 HG+HING hg+hing NN 10_1101-2021_01_06_425584 684 1792 B B NNP 10_1101-2021_01_06_425584 684 1793 A a DT 10_1101-2021_01_06_425584 684 1794 HCAEC HCAEC NNP 10_1101-2021_01_06_425584 684 1795 BCAEC bcaec JJ 10_1101-2021_01_06_425584 684 1796 ≈ ≈ NN 10_1101-2021_01_06_425584 684 1797 30 30 CD 10_1101-2021_01_06_425584 684 1798 % % NN 10_1101-2021_01_06_425584 684 1799 ≈ ≈ NNP 10_1101-2021_01_06_425584 684 1800 58 58 CD 10_1101-2021_01_06_425584 684 1801 % % NN 10_1101-2021_01_06_425584 684 1802 Binucleation Binucleation NNP 10_1101-2021_01_06_425584 684 1803 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 684 1804 BINUCLEATION BINUCLEATION NNP 10_1101-2021_01_06_425584 684 1805 Translation translation NN 10_1101-2021_01_06_425584 684 1806 Nuclei Nuclei NNP 10_1101-2021_01_06_425584 684 1807 Up up RP 10_1101-2021_01_06_425584 684 1808 - - HYPH 10_1101-2021_01_06_425584 684 1809 regulated regulate VBN 10_1101-2021_01_06_425584 684 1810 Down down RP 10_1101-2021_01_06_425584 684 1811 - - HYPH 10_1101-2021_01_06_425584 684 1812 regulated regulate VBN 10_1101-2021_01_06_425584 684 1813 Angiogenesis angiogenesis NN 10_1101-2021_01_06_425584 684 1814 or or CC 10_1101-2021_01_06_425584 684 1815 cell cell NN 10_1101-2021_01_06_425584 684 1816 proliferation proliferation NN 10_1101-2021_01_06_425584 684 1817 CTGF CTGF NNP 10_1101-2021_01_06_425584 684 1818 AFABP AFABP VBD 10_1101-2021_01_06_425584 684 1819 CD62 CD62 NNP 10_1101-2021_01_06_425584 684 1820 CAV-1 CAV-1 NNP 10_1101-2021_01_06_425584 684 1821 RPS7 RPS7 NNP 10_1101-2021_01_06_425584 684 1822 RPS13 RPS13 NNP 10_1101-2021_01_06_425584 684 1823 RPL9 RPL9 NNP 10_1101-2021_01_06_425584 684 1824 PSMA4 PSMA4 '' 10_1101-2021_01_06_425584 684 1825 PSMD3 PSMD3 . 10_1101-2021_01_06_425584 684 1826 Integrated Integrated NNP 10_1101-2021_01_06_425584 684 1827 Analysis Analysis NNP 10_1101-2021_01_06_425584 684 1828 COX4I1 COX4I1 NNP 10_1101-2021_01_06_425584 684 1829 UQCRC1 uqcrc1 XX 10_1101-2021_01_06_425584 684 1830 NDUFB3 ndufb3 CD 10_1101-2021_01_06_425584 684 1831 NDUFA7 NDUFA7 NNP 10_1101-2021_01_06_425584 684 1832 Mitochondrial Mitochondrial NNP 10_1101-2021_01_06_425584 684 1833 inner inner JJ 10_1101-2021_01_06_425584 684 1834 mas mas NN 10_1101-2021_01_06_425584 684 1835 CAVIN3 CAVIN3 NNP 10_1101-2021_01_06_425584 684 1836 Caveolae Caveolae NNP 10_1101-2021_01_06_425584 684 1837 DNA DNA NNP 10_1101-2021_01_06_425584 684 1838 and and CC 10_1101-2021_01_06_425584 684 1839 RNA RNA NNP 10_1101-2021_01_06_425584 684 1840 metabolism metabolism NN 10_1101-2021_01_06_425584 684 1841 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1842 H H NNP 10_1101-2021_01_06_425584 684 1843 N n NN 10_1101-2021_01_06_425584 684 1844 O o NN 10_1101-2021_01_06_425584 684 1845 OH oh UH 10_1101-2021_01_06_425584 684 1846 NH2O nh2o UH 10_1101-2021_01_06_425584 684 1847 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1848 O O NNP 10_1101-2021_01_06_425584 684 1849 OH oh NN 10_1101-2021_01_06_425584 684 1850 Tryptophan Tryptophan NNP 10_1101-2021_01_06_425584 684 1851 SerotoninKynurenine SerotoninKynurenine NNP 10_1101-2021_01_06_425584 684 1852 Catabolism Catabolism NNP 10_1101-2021_01_06_425584 684 1853 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1854 H H NNP 10_1101-2021_01_06_425584 684 1855 N N NNP 10_1101-2021_01_06_425584 684 1856 HO HO NNP 10_1101-2021_01_06_425584 684 1857 N n NN 10_1101-2021_01_06_425584 684 1858 H h NN 10_1101-2021_01_06_425584 684 1859 O o NN 10_1101-2021_01_06_425584 684 1860 OH oh NN 10_1101-2021_01_06_425584 684 1861 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1862 O o UH 10_1101-2021_01_06_425584 684 1863 HO ho NN 10_1101-2021_01_06_425584 684 1864 O o NN 10_1101-2021_01_06_425584 684 1865 H2N h2n NN 10_1101-2021_01_06_425584 684 1866 O o UH 10_1101-2021_01_06_425584 684 1867 OH OH NNP 10_1101-2021_01_06_425584 684 1868 Glutamyl Glutamyl NNP 10_1101-2021_01_06_425584 684 1869 - - HYPH 10_1101-2021_01_06_425584 684 1870 phenylalanine phenylalanine NNP 10_1101-2021_01_06_425584 684 1871 Phenylalanine Phenylalanine NNP 10_1101-2021_01_06_425584 684 1872 - - HYPH 10_1101-2021_01_06_425584 684 1873 based base VBN 10_1101-2021_01_06_425584 684 1874 metabolites metabolite NNS 10_1101-2021_01_06_425584 684 1875 Phenylalanine Phenylalanine NNP 10_1101-2021_01_06_425584 684 1876 O O NNP 10_1101-2021_01_06_425584 684 1877 P p NN 10_1101-2021_01_06_425584 684 1878 O o NN 10_1101-2021_01_06_425584 684 1879 OO oo NN 10_1101-2021_01_06_425584 684 1880 N+ N+ VBN 10_1101-2021_01_06_425584 684 1881 O o NN 10_1101-2021_01_06_425584 684 1882 O o NN 10_1101-2021_01_06_425584 684 1883 H h NN 10_1101-2021_01_06_425584 684 1884 R1 r1 NN 10_1101-2021_01_06_425584 684 1885 PAFAH1B2 PAFAH1B2 NNP 10_1101-2021_01_06_425584 684 1886 Deacylation Deacylation NNP 10_1101-2021_01_06_425584 684 1887 LysoPC LysoPC NNP 10_1101-2021_01_06_425584 684 1888 lipids lipid VBZ 10_1101-2021_01_06_425584 684 1889 PC pc NN 10_1101-2021_01_06_425584 684 1890 lipids lipid NNS 10_1101-2021_01_06_425584 684 1891 OH oh NN 10_1101-2021_01_06_425584 684 1892 P p NN 10_1101-2021_01_06_425584 684 1893 O o NN 10_1101-2021_01_06_425584 684 1894 OHO oho NN 10_1101-2021_01_06_425584 684 1895 N+ N+ VBN 10_1101-2021_01_06_425584 684 1896 Phosphocholine Phosphocholine NNP 10_1101-2021_01_06_425584 684 1897 O O NNP 10_1101-2021_01_06_425584 684 1898 P p NN 10_1101-2021_01_06_425584 684 1899 O o NN 10_1101-2021_01_06_425584 684 1900 OO oo NN 10_1101-2021_01_06_425584 684 1901 N+ N+ VBN 10_1101-2021_01_06_425584 684 1902 O o NN 10_1101-2021_01_06_425584 684 1903 O o NN 10_1101-2021_01_06_425584 684 1904 R2 r2 NN 10_1101-2021_01_06_425584 684 1905 R1 r1 NN 10_1101-2021_01_06_425584 684 1906 LYPLA1 lypla1 NN 10_1101-2021_01_06_425584 684 1907 Degradation Degradation NNP 10_1101-2021_01_06_425584 684 1908 Inflammation Inflammation NNP 10_1101-2021_01_06_425584 684 1909 Catabolism Catabolism NNP 10_1101-2021_01_06_425584 684 1910 Oxidative Oxidative NNP 10_1101-2021_01_06_425584 684 1911 stress stress NN 10_1101-2021_01_06_425584 684 1912 Peptides Peptides NNPS 10_1101-2021_01_06_425584 684 1913 NH2 NH2 NNP 10_1101-2021_01_06_425584 684 1914 O o UH 10_1101-2021_01_06_425584 684 1915 HO ho NN 10_1101-2021_01_06_425584 684 1916 O o NN 10_1101-2021_01_06_425584 684 1917 OHOrnitine ohornitine NN 10_1101-2021_01_06_425584 684 1918 OAT OAT NNP 10_1101-2021_01_06_425584 684 1919 Glutamic Glutamic NNP 10_1101-2021_01_06_425584 684 1920 acid acid NN 10_1101-2021_01_06_425584 684 1921 NH NH NNP 10_1101-2021_01_06_425584 684 1922 O o NN 10_1101-2021_01_06_425584 684 1923 OH oh NN 10_1101-2021_01_06_425584 684 1924 O o NN 10_1101-2021_01_06_425584 684 1925 H h NN 10_1101-2021_01_06_425584 684 1926 N n NN 10_1101-2021_01_06_425584 684 1927 OH oh NN 10_1101-2021_01_06_425584 684 1928 OSH OSH NNP 10_1101-2021_01_06_425584 684 1929 N N NNP 10_1101-2021_01_06_425584 684 1930 HNH2 HNH2 NNP 10_1101-2021_01_06_425584 684 1931 HO HO NNP 10_1101-2021_01_06_425584 684 1932 O o NN 10_1101-2021_01_06_425584 684 1933 O o NN 10_1101-2021_01_06_425584 684 1934 Ox Ox NNP 10_1101-2021_01_06_425584 684 1935 - - HYPH 10_1101-2021_01_06_425584 684 1936 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 684 1937 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 684 1938 - - HYPH 10_1101-2021_01_06_425584 684 1939 based base VBN 10_1101-2021_01_06_425584 684 1940 metabolites metabolite NNS 10_1101-2021_01_06_425584 684 1941 PRDX2 prdx2 DT 10_1101-2021_01_06_425584 684 1942 PRDX6 prdx6 NN 10_1101-2021_01_06_425584 684 1943 TXN2 TXN2 NNP 10_1101-2021_01_06_425584 684 1944 ROS ROS NNP 10_1101-2021_01_06_425584 684 1945 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 684 1946 Proline Proline NNP 10_1101-2021_01_06_425584 684 1947 Mitochondria Mitochondria NNP 10_1101-2021_01_06_425584 684 1948 Table Table NNP 10_1101-2021_01_06_425584 684 1949 1 1 CD 10_1101-2021_01_06_425584 684 1950 . . . 10_1101-2021_01_06_425584 685 1 Pathway pathway JJ 10_1101-2021_01_06_425584 685 2 enrichment enrichment NN 10_1101-2021_01_06_425584 685 3 analysis analysis NN 10_1101-2021_01_06_425584 685 4 of of IN 10_1101-2021_01_06_425584 685 5 up up RB 10_1101-2021_01_06_425584 685 6 - - HYPH 10_1101-2021_01_06_425584 685 7 regulated regulated JJ 10_1101-2021_01_06_425584 685 8 and and CC 10_1101-2021_01_06_425584 685 9 down down RB 10_1101-2021_01_06_425584 685 10 - - HYPH 10_1101-2021_01_06_425584 685 11 regulated regulate VBN 10_1101-2021_01_06_425584 685 12 proteins protein NNS 10_1101-2021_01_06_425584 685 13 in in IN 10_1101-2021_01_06_425584 685 14 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 685 15 group group NN 10_1101-2021_01_06_425584 685 16 REACTOME REACTOME NNP 10_1101-2021_01_06_425584 685 17 Database Database NNP 10_1101-2021_01_06_425584 685 18 Total Total NNP 10_1101-2021_01_06_425584 685 19 Hits Hits NNP 10_1101-2021_01_06_425584 685 20 FDR FDR NNP 10_1101-2021_01_06_425584 685 21 Total Total NNP 10_1101-2021_01_06_425584 685 22 Hits Hits NNP 10_1101-2021_01_06_425584 685 23 FDR FDR NNP 10_1101-2021_01_06_425584 685 24 Up up RP 10_1101-2021_01_06_425584 685 25 - - HYPH 10_1101-2021_01_06_425584 685 26 regulated regulate VBN 10_1101-2021_01_06_425584 685 27 Down down RP 10_1101-2021_01_06_425584 685 28 - - HYPH 10_1101-2021_01_06_425584 685 29 regulated regulated JJ 10_1101-2021_01_06_425584 685 30 Metabolism Metabolism NNP 10_1101-2021_01_06_425584 685 31 of of IN 10_1101-2021_01_06_425584 685 32 RNA RNA NNP 10_1101-2021_01_06_425584 685 33 339 339 CD 10_1101-2021_01_06_425584 685 34 142 142 CD 10_1101-2021_01_06_425584 685 35 1.26E- 1.26e- CD 10_1101-2021_01_06_425584 685 36 100 100 CD 10_1101-2021_01_06_425584 685 37 Peptide peptide NN 10_1101-2021_01_06_425584 685 38 chain chain NN 10_1101-2021_01_06_425584 685 39 elongation elongation NN 10_1101-2021_01_06_425584 685 40 178 178 CD 10_1101-2021_01_06_425584 685 41 77 77 CD 10_1101-2021_01_06_425584 685 42 5.81E- 5.81e- CD 10_1101-2021_01_06_425584 685 43 48 48 CD 10_1101-2021_01_06_425584 685 44 Metabolism metabolism NN 10_1101-2021_01_06_425584 685 45 of of IN 10_1101-2021_01_06_425584 685 46 mRNA mrna $ 10_1101-2021_01_06_425584 685 47 317 317 CD 10_1101-2021_01_06_425584 685 48 136 136 CD 10_1101-2021_01_06_425584 685 49 1.04E-97 1.04e-97 CD 10_1101-2021_01_06_425584 685 50 Influenza Influenza NNP 10_1101-2021_01_06_425584 685 51 Infection Infection NNP 10_1101-2021_01_06_425584 685 52 185 185 CD 10_1101-2021_01_06_425584 685 53 78 78 CD 10_1101-2021_01_06_425584 685 54 6.52E- 6.52e- CD 10_1101-2021_01_06_425584 685 55 48 48 CD 10_1101-2021_01_06_425584 685 56 Synthesis Synthesis NNP 10_1101-2021_01_06_425584 685 57 of of IN 10_1101-2021_01_06_425584 685 58 DNA dna NN 10_1101-2021_01_06_425584 685 59 95 95 CD 10_1101-2021_01_06_425584 685 60 75 75 CD 10_1101-2021_01_06_425584 685 61 2.37E-79 2.37e-79 CD 10_1101-2021_01_06_425584 685 62 Nonsense Nonsense NNP 10_1101-2021_01_06_425584 685 63 Mediated mediate VBN 10_1101-2021_01_06_425584 685 64 Decay Decay NNP 10_1101-2021_01_06_425584 685 65 Independent Independent NNP 10_1101-2021_01_06_425584 685 66 of of IN 10_1101-2021_01_06_425584 685 67 the the DT 10_1101-2021_01_06_425584 685 68 Exon Exon NNP 10_1101-2021_01_06_425584 685 69 Junction Junction NNP 10_1101-2021_01_06_425584 685 70 Complex Complex NNP 10_1101-2021_01_06_425584 685 71 184 184 CD 10_1101-2021_01_06_425584 685 72 77 77 CD 10_1101-2021_01_06_425584 685 73 4.04E- 4.04e- CD 10_1101-2021_01_06_425584 685 74 47 47 CD 10_1101-2021_01_06_425584 685 75 DNA DNA NNP 10_1101-2021_01_06_425584 685 76 Replication Replication NNP 10_1101-2021_01_06_425584 685 77 102 102 CD 10_1101-2021_01_06_425584 685 78 77 77 CD 10_1101-2021_01_06_425584 685 79 5.67E-79 5.67e-79 CD 10_1101-2021_01_06_425584 685 80 Influenza Influenza NNP 10_1101-2021_01_06_425584 685 81 Life Life NNP 10_1101-2021_01_06_425584 685 82 Cycle Cycle NNP 10_1101-2021_01_06_425584 685 83 180 180 CD 10_1101-2021_01_06_425584 685 84 76 76 CD 10_1101-2021_01_06_425584 685 85 4.63E- 4.63e- CD 10_1101-2021_01_06_425584 685 86 47 47 CD 10_1101-2021_01_06_425584 685 87 DNA dna NN 10_1101-2021_01_06_425584 685 88 Replication Replication NNP 10_1101-2021_01_06_425584 685 89 Pre Pre NNP 10_1101-2021_01_06_425584 685 90 - - HYPH 10_1101-2021_01_06_425584 685 91 Initiation Initiation NNP 10_1101-2021_01_06_425584 685 92 80 80 CD 10_1101-2021_01_06_425584 685 93 68 68 CD 10_1101-2021_01_06_425584 685 94 3.49E-76 3.49e-76 CD 10_1101-2021_01_06_425584 685 95 Eukaryotic Eukaryotic NNP 10_1101-2021_01_06_425584 685 96 Translation Translation NNP 10_1101-2021_01_06_425584 685 97 Elongation Elongation NNP 10_1101-2021_01_06_425584 685 98 186 186 CD 10_1101-2021_01_06_425584 685 99 77 77 CD 10_1101-2021_01_06_425584 685 100 4.63E- 4.63e- CD 10_1101-2021_01_06_425584 685 101 47 47 CD 10_1101-2021_01_06_425584 685 102 M M NNP 10_1101-2021_01_06_425584 685 103 / / SYM 10_1101-2021_01_06_425584 685 104 G1 G1 NNP 10_1101-2021_01_06_425584 685 105 Transition Transition NNP 10_1101-2021_01_06_425584 685 106 80 80 CD 10_1101-2021_01_06_425584 685 107 68 68 CD 10_1101-2021_01_06_425584 685 108 3.49E-76 3.49e-76 CD 10_1101-2021_01_06_425584 685 109 Nonsense nonsense NN 10_1101-2021_01_06_425584 685 110 Mediated mediate VBN 10_1101-2021_01_06_425584 685 111 Decay Decay NNP 10_1101-2021_01_06_425584 685 112 Enhanced enhance VBN 10_1101-2021_01_06_425584 685 113 by by IN 10_1101-2021_01_06_425584 685 114 the the DT 10_1101-2021_01_06_425584 685 115 Exon Exon NNP 10_1101-2021_01_06_425584 685 116 Junction Junction NNP 10_1101-2021_01_06_425584 685 117 Complex Complex NNP 10_1101-2021_01_06_425584 685 118 203 203 CD 10_1101-2021_01_06_425584 685 119 80 80 CD 10_1101-2021_01_06_425584 685 120 4.63E- 4.63e- CD 10_1101-2021_01_06_425584 685 121 47 47 CD 10_1101-2021_01_06_425584 685 122 S S NNP 10_1101-2021_01_06_425584 685 123 Phase Phase NNP 10_1101-2021_01_06_425584 685 124 122 122 CD 10_1101-2021_01_06_425584 685 125 78 78 CD 10_1101-2021_01_06_425584 685 126 4.62E-71 4.62e-71 CD 10_1101-2021_01_06_425584 685 127 Nonsense Nonsense NNP 10_1101-2021_01_06_425584 685 128 - - HYPH 10_1101-2021_01_06_425584 685 129 Mediated Mediated NNP 10_1101-2021_01_06_425584 685 130 Decay Decay NNP 10_1101-2021_01_06_425584 685 131 203 203 CD 10_1101-2021_01_06_425584 685 132 80 80 CD 10_1101-2021_01_06_425584 685 133 4.63E- 4.63e- CD 10_1101-2021_01_06_425584 685 134 47 47 CD 10_1101-2021_01_06_425584 685 135 G1 g1 NN 10_1101-2021_01_06_425584 685 136 / / SYM 10_1101-2021_01_06_425584 685 137 S S NNP 10_1101-2021_01_06_425584 685 138 Transition Transition NNP 10_1101-2021_01_06_425584 685 139 113 113 CD 10_1101-2021_01_06_425584 685 140 75 75 CD 10_1101-2021_01_06_425584 685 141 4.37E-70 4.37e-70 CD 10_1101-2021_01_06_425584 685 142 Influenza Influenza NNP 10_1101-2021_01_06_425584 685 143 Viral Viral NNP 10_1101-2021_01_06_425584 685 144 RNA RNA NNP 10_1101-2021_01_06_425584 685 145 Transcription Transcription NNP 10_1101-2021_01_06_425584 685 146 and and CC 10_1101-2021_01_06_425584 685 147 Replication Replication NNP 10_1101-2021_01_06_425584 685 148 176 176 CD 10_1101-2021_01_06_425584 685 149 75 75 CD 10_1101-2021_01_06_425584 685 150 5.77E- 5.77e- CD 10_1101-2021_01_06_425584 685 151 47 47 CD 10_1101-2021_01_06_425584 685 152 Assembly assembly NN 10_1101-2021_01_06_425584 685 153 of of IN 10_1101-2021_01_06_425584 685 154 the the DT 10_1101-2021_01_06_425584 685 155 pre- pre- NN 10_1101-2021_01_06_425584 685 156 replicative replicative JJ 10_1101-2021_01_06_425584 685 157 complex complex NNP 10_1101-2021_01_06_425584 685 158 63 63 CD 10_1101-2021_01_06_425584 685 159 57 57 CD 10_1101-2021_01_06_425584 685 160 5.61E-67 5.61e-67 CD 10_1101-2021_01_06_425584 685 161 Viral Viral NNP 10_1101-2021_01_06_425584 685 162 mRNA mrna NN 10_1101-2021_01_06_425584 685 163 Translation translation NN 10_1101-2021_01_06_425584 685 164 176 176 CD 10_1101-2021_01_06_425584 685 165 75 75 CD 10_1101-2021_01_06_425584 685 166 5.77E- 5.77e- CD 10_1101-2021_01_06_425584 685 167 47 47 CD 10_1101-2021_01_06_425584 685 168 Metabolism metabolism NN 10_1101-2021_01_06_425584 685 169 of of IN 10_1101-2021_01_06_425584 685 170 RNA RNA NNP 10_1101-2021_01_06_425584 685 171 339 339 CD 10_1101-2021_01_06_425584 685 172 142 142 CD 10_1101-2021_01_06_425584 685 173 1.26E- 1.26e- CD 10_1101-2021_01_06_425584 685 174 100 100 CD 10_1101-2021_01_06_425584 685 175 Eukaryotic Eukaryotic NNP 10_1101-2021_01_06_425584 685 176 Translation Translation NNP 10_1101-2021_01_06_425584 685 177 Termination Termination NNP 10_1101-2021_01_06_425584 685 178 178 178 CD 10_1101-2021_01_06_425584 685 179 75 75 CD 10_1101-2021_01_06_425584 685 180 1.42E- 1.42e- CD 10_1101-2021_01_06_425584 685 181 46 46 CD 10_1101-2021_01_06_425584 685 182 KEGG KEGG NNP 10_1101-2021_01_06_425584 685 183 Database Database NNP 10_1101-2021_01_06_425584 685 184 Up up RP 10_1101-2021_01_06_425584 685 185 - - HYPH 10_1101-2021_01_06_425584 685 186 regulated regulate VBN 10_1101-2021_01_06_425584 685 187 Down down RP 10_1101-2021_01_06_425584 685 188 - - HYPH 10_1101-2021_01_06_425584 685 189 regulated regulate VBN 10_1101-2021_01_06_425584 685 190 Basal Basal NNP 10_1101-2021_01_06_425584 685 191 transcription transcription NN 10_1101-2021_01_06_425584 685 192 factors factor VBZ 10_1101-2021_01_06_425584 685 193 153 153 CD 10_1101-2021_01_06_425584 685 194 111 111 CD 10_1101-2021_01_06_425584 685 195 2.17E- 2.17e- CD 10_1101-2021_01_06_425584 685 196 115 115 CD 10_1101-2021_01_06_425584 685 197 Basal Basal NNP 10_1101-2021_01_06_425584 685 198 transcription transcription NN 10_1101-2021_01_06_425584 685 199 factors factor NNS 10_1101-2021_01_06_425584 685 200 153 153 CD 10_1101-2021_01_06_425584 685 201 88 88 CD 10_1101-2021_01_06_425584 685 202 8.15E- 8.15e- CD 10_1101-2021_01_06_425584 685 203 73 73 CD 10_1101-2021_01_06_425584 685 204 Mismatch Mismatch NNP 10_1101-2021_01_06_425584 685 205 repair repair NN 10_1101-2021_01_06_425584 685 206 45 45 CD 10_1101-2021_01_06_425584 685 207 43 43 CD 10_1101-2021_01_06_425584 685 208 1.68E-53 1.68e-53 CD 10_1101-2021_01_06_425584 685 209 Nucleotide nucleotide JJ 10_1101-2021_01_06_425584 685 210 excision excision NN 10_1101-2021_01_06_425584 685 211 repair repair NN 10_1101-2021_01_06_425584 685 212 135 135 CD 10_1101-2021_01_06_425584 685 213 46 46 CD 10_1101-2021_01_06_425584 685 214 3.62E- 3.62e- CD 10_1101-2021_01_06_425584 685 215 24 24 CD 10_1101-2021_01_06_425584 685 216 SNARE SNARE NNP 10_1101-2021_01_06_425584 685 217 interactions interaction NNS 10_1101-2021_01_06_425584 685 218 in in IN 10_1101-2021_01_06_425584 685 219 vesicular vesicular JJ 10_1101-2021_01_06_425584 685 220 transport transport NN 10_1101-2021_01_06_425584 685 221 124 124 CD 10_1101-2021_01_06_425584 685 222 41 41 CD 10_1101-2021_01_06_425584 685 223 2.28E-22 2.28e-22 CD 10_1101-2021_01_06_425584 685 224 Renal renal JJ 10_1101-2021_01_06_425584 685 225 cell cell NN 10_1101-2021_01_06_425584 685 226 carcinoma carcinoma NN 10_1101-2021_01_06_425584 685 227 201 201 CD 10_1101-2021_01_06_425584 685 228 46 46 CD 10_1101-2021_01_06_425584 685 229 2.26E- 2.26e- CD 10_1101-2021_01_06_425584 685 230 16 16 CD 10_1101-2021_01_06_425584 685 231 Base Base NNP 10_1101-2021_01_06_425584 685 232 excision excision NN 10_1101-2021_01_06_425584 685 233 repair repair NN 10_1101-2021_01_06_425584 685 234 36 36 CD 10_1101-2021_01_06_425584 685 235 18 18 CD 10_1101-2021_01_06_425584 685 236 3.46E-13 3.46e-13 CD 10_1101-2021_01_06_425584 685 237 Endometrial Endometrial NNP 10_1101-2021_01_06_425584 685 238 cancer cancer NN 10_1101-2021_01_06_425584 685 239 204 204 CD 10_1101-2021_01_06_425584 685 240 45 45 CD 10_1101-2021_01_06_425584 685 241 1.88E- 1.88e- CD 10_1101-2021_01_06_425584 685 242 15 15 CD 10_1101-2021_01_06_425584 685 243 Human human NN 10_1101-2021_01_06_425584 685 244 papillomavirus papillomavirus NN 10_1101-2021_01_06_425584 685 245 infection infection NN 10_1101-2021_01_06_425584 685 246 155 155 CD 10_1101-2021_01_06_425584 685 247 34 34 CD 10_1101-2021_01_06_425584 685 248 1.62E-12 1.62e-12 CD 10_1101-2021_01_06_425584 685 249 Peroxisome peroxisome NN 10_1101-2021_01_06_425584 685 250 137 137 CD 10_1101-2021_01_06_425584 685 251 35 35 CD 10_1101-2021_01_06_425584 685 252 5.32E- 5.32e- CD 10_1101-2021_01_06_425584 685 253 14 14 CD 10_1101-2021_01_06_425584 685 254 Chemical Chemical NNP 10_1101-2021_01_06_425584 685 255 carcinogenesis carcinogenesis NN 10_1101-2021_01_06_425584 685 256 201 201 CD 10_1101-2021_01_06_425584 685 257 36 36 CD 10_1101-2021_01_06_425584 685 258 1.50E-10 1.50e-10 CD 10_1101-2021_01_06_425584 685 259 Nicotine Nicotine NNP 10_1101-2021_01_06_425584 685 260 addiction addiction NN 10_1101-2021_01_06_425584 685 261 193 193 CD 10_1101-2021_01_06_425584 685 262 41 41 CD 10_1101-2021_01_06_425584 685 263 1.48E- 1.48e- CD 10_1101-2021_01_06_425584 685 264 13 13 CD 10_1101-2021_01_06_425584 685 265 Hepatocellular Hepatocellular NNP 10_1101-2021_01_06_425584 685 266 carcinoma carcinoma NN 10_1101-2021_01_06_425584 685 267 76 76 CD 10_1101-2021_01_06_425584 685 268 18 18 CD 10_1101-2021_01_06_425584 685 269 4.74E-07 4.74e-07 CD 10_1101-2021_01_06_425584 685 270 Ribosome Ribosome NNP 10_1101-2021_01_06_425584 685 271 biogenesis biogenesis NN 10_1101-2021_01_06_425584 685 272 in in IN 10_1101-2021_01_06_425584 685 273 eukaryotes eukaryote NNS 10_1101-2021_01_06_425584 685 274 79 79 CD 10_1101-2021_01_06_425584 685 275 26 26 CD 10_1101-2021_01_06_425584 685 276 2.92E- 2.92e- CD 10_1101-2021_01_06_425584 685 277 13 13 CD 10_1101-2021_01_06_425584 685 278 Human Human NNP 10_1101-2021_01_06_425584 685 279 T T NNP 10_1101-2021_01_06_425584 685 280 - - HYPH 10_1101-2021_01_06_425584 685 281 cell cell NN 10_1101-2021_01_06_425584 685 282 leukemia leukemia NN 10_1101-2021_01_06_425584 685 283 virus virus NN 10_1101-2021_01_06_425584 685 284 1 1 CD 10_1101-2021_01_06_425584 685 285 infection infection NN 10_1101-2021_01_06_425584 685 286 162 162 CD 10_1101-2021_01_06_425584 685 287 26 26 CD 10_1101-2021_01_06_425584 685 288 1.49E-06 1.49e-06 CD 10_1101-2021_01_06_425584 685 289 Gap Gap NNP 10_1101-2021_01_06_425584 685 290 junction junction NN 10_1101-2021_01_06_425584 685 291 199 199 CD 10_1101-2021_01_06_425584 685 292 41 41 CD 10_1101-2021_01_06_425584 685 293 3.40E- 3.40e- CD 10_1101-2021_01_06_425584 685 294 13 13 CD 10_1101-2021_01_06_425584 685 295 Chronic chronic NN 10_1101-2021_01_06_425584 685 296 myeloid myeloid NN 10_1101-2021_01_06_425584 685 297 leukemia leukemia NN 10_1101-2021_01_06_425584 685 298 97 97 CD 10_1101-2021_01_06_425584 685 299 19 19 CD 10_1101-2021_01_06_425584 685 300 3.79E-06 3.79e-06 CD 10_1101-2021_01_06_425584 685 301 Herpes Herpes NNP 10_1101-2021_01_06_425584 685 302 simplex simplex NN 10_1101-2021_01_06_425584 685 303 virus virus NN 10_1101-2021_01_06_425584 685 304 1 1 CD 10_1101-2021_01_06_425584 685 305 infection infection NN 10_1101-2021_01_06_425584 685 306 225 225 CD 10_1101-2021_01_06_425584 685 307 42 42 CD 10_1101-2021_01_06_425584 685 308 5.11E- 5.11e- CD 10_1101-2021_01_06_425584 685 309 12 12 CD 10_1101-2021_01_06_425584 685 310 Notch Notch NNP 10_1101-2021_01_06_425584 685 311 signaling signal VBG 10_1101-2021_01_06_425584 685 312 pathway pathway JJ 10_1101-2021_01_06_425584 685 313 160 160 CD 10_1101-2021_01_06_425584 685 314 25 25 CD 10_1101-2021_01_06_425584 685 315 3.79E-06 3.79e-06 CD 10_1101-2021_01_06_425584 685 316 Glutamatergic Glutamatergic NNP 10_1101-2021_01_06_425584 685 317 synapse synapse VBD 10_1101-2021_01_06_425584 685 318 231 231 CD 10_1101-2021_01_06_425584 685 319 36 36 CD 10_1101-2021_01_06_425584 685 320 1.02E- 1.02e- CD 10_1101-2021_01_06_425584 685 321 14 14 CD 10_1101-2021_01_06_425584 685 322 Table table NN 10_1101-2021_01_06_425584 685 323 2 2 CD 10_1101-2021_01_06_425584 685 324 . . . 10_1101-2021_01_06_425584 686 1 Integrative integrative JJ 10_1101-2021_01_06_425584 686 2 pathway pathway JJ 10_1101-2021_01_06_425584 686 3 enrichment enrichment NN 10_1101-2021_01_06_425584 686 4 analysis analysis NN 10_1101-2021_01_06_425584 686 5 of of IN 10_1101-2021_01_06_425584 686 6 up up RB 10_1101-2021_01_06_425584 686 7 - - HYPH 10_1101-2021_01_06_425584 686 8 regulated regulated JJ 10_1101-2021_01_06_425584 686 9 proteins protein NNS 10_1101-2021_01_06_425584 686 10 and and CC 10_1101-2021_01_06_425584 686 11 metabolites metabolite NNS 10_1101-2021_01_06_425584 686 12 in in IN 10_1101-2021_01_06_425584 686 13 HG+HI HG+HI NNP 10_1101-2021_01_06_425584 686 14 group group NN 10_1101-2021_01_06_425584 686 15 REACTOME REACTOME NNP 10_1101-2021_01_06_425584 686 16 Database Database NNP 10_1101-2021_01_06_425584 686 17 Total Total NNP 10_1101-2021_01_06_425584 686 18 Hits Hits NNP 10_1101-2021_01_06_425584 686 19 FDR FDR NNP 10_1101-2021_01_06_425584 686 20 KEGG KEGG NNP 10_1101-2021_01_06_425584 686 21 Database Database NNP 10_1101-2021_01_06_425584 686 22 Total Total NNP 10_1101-2021_01_06_425584 686 23 Hits Hits NNP 10_1101-2021_01_06_425584 686 24 FDR FDR NNP 10_1101-2021_01_06_425584 686 25 Metabolism Metabolism NNP 10_1101-2021_01_06_425584 686 26 of of IN 10_1101-2021_01_06_425584 686 27 amino amino JJ 10_1101-2021_01_06_425584 686 28 acids acid NNS 10_1101-2021_01_06_425584 686 29 and and CC 10_1101-2021_01_06_425584 686 30 derivatives derivative NNS 10_1101-2021_01_06_425584 686 31 190 190 CD 10_1101-2021_01_06_425584 686 32 44 44 CD 10_1101-2021_01_06_425584 686 33 8.74E-39 8.74e-39 CD 10_1101-2021_01_06_425584 686 34 EGFR EGFR NNP 10_1101-2021_01_06_425584 686 35 tyrosine tyrosine JJ 10_1101-2021_01_06_425584 686 36 kinase kinase NN 10_1101-2021_01_06_425584 686 37 inhibitor inhibitor NN 10_1101-2021_01_06_425584 686 38 resistance resistance NN 10_1101-2021_01_06_425584 686 39 1490 1490 CD 10_1101-2021_01_06_425584 686 40 129 129 CD 10_1101-2021_01_06_425584 686 41 1.01E- 1.01e- CD 10_1101-2021_01_06_425584 686 42 72 72 CD 10_1101-2021_01_06_425584 686 43 Metabolism Metabolism NNP 10_1101-2021_01_06_425584 686 44 1490 1490 CD 10_1101-2021_01_06_425584 686 45 85 85 CD 10_1101-2021_01_06_425584 686 46 1.33E-35 1.33e-35 CD 10_1101-2021_01_06_425584 686 47 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 686 48 metabolism metabolism NN 10_1101-2021_01_06_425584 686 49 56 56 CD 10_1101-2021_01_06_425584 686 50 39 39 CD 10_1101-2021_01_06_425584 686 51 1.63E- 1.63e- CD 10_1101-2021_01_06_425584 686 52 54 54 CD 10_1101-2021_01_06_425584 686 53 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 686 54 conjugation conjugation NN 10_1101-2021_01_06_425584 686 55 25 25 CD 10_1101-2021_01_06_425584 686 56 21 21 CD 10_1101-2021_01_06_425584 686 57 7.33E-33 7.33e-33 CD 10_1101-2021_01_06_425584 686 58 Alanine Alanine NNP 10_1101-2021_01_06_425584 686 59 , , , 10_1101-2021_01_06_425584 686 60 aspartate aspartate NN 10_1101-2021_01_06_425584 686 61 and and CC 10_1101-2021_01_06_425584 686 62 glutamate glutamate VB 10_1101-2021_01_06_425584 686 63 metabolism metabolism NN 10_1101-2021_01_06_425584 686 64 36 36 CD 10_1101-2021_01_06_425584 686 65 24 24 CD 10_1101-2021_01_06_425584 686 66 4.57E- 4.57e- CD 10_1101-2021_01_06_425584 686 67 32 32 CD 10_1101-2021_01_06_425584 686 68 Phase phase NN 10_1101-2021_01_06_425584 686 69 II ii CD 10_1101-2021_01_06_425584 686 70 conjugation conjugation NN 10_1101-2021_01_06_425584 686 71 74 74 CD 10_1101-2021_01_06_425584 686 72 25 25 CD 10_1101-2021_01_06_425584 686 73 2.04E-25 2.04e-25 CD 10_1101-2021_01_06_425584 686 74 ABC ABC NNP 10_1101-2021_01_06_425584 686 75 transporters transporter NNS 10_1101-2021_01_06_425584 686 76 75 75 CD 10_1101-2021_01_06_425584 686 77 27 27 CD 10_1101-2021_01_06_425584 686 78 1.09E- 1.09e- CD 10_1101-2021_01_06_425584 686 79 26 26 CD 10_1101-2021_01_06_425584 686 80 Amino amino JJ 10_1101-2021_01_06_425584 686 81 acid acid JJ 10_1101-2021_01_06_425584 686 82 synthesis synthesis NN 10_1101-2021_01_06_425584 686 83 and and CC 10_1101-2021_01_06_425584 686 84 interconversion interconversion NN 10_1101-2021_01_06_425584 686 85 ( ( -LRB- 10_1101-2021_01_06_425584 686 86 transamination transamination NN 10_1101-2021_01_06_425584 686 87 ) ) -RRB- 10_1101-2021_01_06_425584 686 88 18 18 CD 10_1101-2021_01_06_425584 686 89 15 15 CD 10_1101-2021_01_06_425584 686 90 5.97E-23 5.97e-23 CD 10_1101-2021_01_06_425584 686 91 Cysteine Cysteine NNP 10_1101-2021_01_06_425584 686 92 and and CC 10_1101-2021_01_06_425584 686 93 methionine methionine NNP 10_1101-2021_01_06_425584 686 94 metabolism metabolism NN 10_1101-2021_01_06_425584 686 95 49 49 CD 10_1101-2021_01_06_425584 686 96 22 22 CD 10_1101-2021_01_06_425584 686 97 3.48E- 3.48e- CD 10_1101-2021_01_06_425584 686 98 24 24 CD 10_1101-2021_01_06_425584 686 99 Biological biological JJ 10_1101-2021_01_06_425584 686 100 oxidations oxidation NNS 10_1101-2021_01_06_425584 686 101 142 142 CD 10_1101-2021_01_06_425584 686 102 25 25 CD 10_1101-2021_01_06_425584 686 103 7.73E-18 7.73e-18 CD 10_1101-2021_01_06_425584 686 104 Pancreatic pancreatic JJ 10_1101-2021_01_06_425584 686 105 cancer cancer NN 10_1101-2021_01_06_425584 686 106 82 82 CD 10_1101-2021_01_06_425584 686 107 23 23 CD 10_1101-2021_01_06_425584 686 108 7.55E- 7.55e- CD 10_1101-2021_01_06_425584 686 109 20 20 CD 10_1101-2021_01_06_425584 686 110 tRNA trna CD 10_1101-2021_01_06_425584 686 111 Aminoacylation Aminoacylation NNP 10_1101-2021_01_06_425584 686 112 42 42 CD 10_1101-2021_01_06_425584 686 113 13 13 CD 10_1101-2021_01_06_425584 686 114 5.19E-12 5.19e-12 CD 10_1101-2021_01_06_425584 686 115 Drug drug NN 10_1101-2021_01_06_425584 686 116 metabolism metabolism NN 10_1101-2021_01_06_425584 686 117 - - HYPH 10_1101-2021_01_06_425584 686 118 cytochrome cytochrome VBN 10_1101-2021_01_06_425584 686 119 P450 P450 NNP 10_1101-2021_01_06_425584 686 120 72 72 CD 10_1101-2021_01_06_425584 686 121 21 21 CD 10_1101-2021_01_06_425584 686 122 1.67E- 1.67e- CD 10_1101-2021_01_06_425584 686 123 18 18 CD 10_1101-2021_01_06_425584 686 124 Glutathione Glutathione NNP 10_1101-2021_01_06_425584 686 125 synthesis synthesis NN 10_1101-2021_01_06_425584 686 126 and and CC 10_1101-2021_01_06_425584 686 127 recycling recycle VBG 10_1101-2021_01_06_425584 686 128 10 10 CD 10_1101-2021_01_06_425584 686 129 7 7 CD 10_1101-2021_01_06_425584 686 130 3.67E-09 3.67e-09 CD 10_1101-2021_01_06_425584 686 131 Metabolism metabolism NN 10_1101-2021_01_06_425584 686 132 of of IN 10_1101-2021_01_06_425584 686 133 xenobiotics xenobiotic NNS 10_1101-2021_01_06_425584 686 134 by by IN 10_1101-2021_01_06_425584 686 135 cytochrome cytochrome NNP 10_1101-2021_01_06_425584 686 136 P450 P450 NNP 10_1101-2021_01_06_425584 686 137 76 76 CD 10_1101-2021_01_06_425584 686 138 21 21 CD 10_1101-2021_01_06_425584 686 139 5.18E- 5.18e- CD 10_1101-2021_01_06_425584 686 140 18 18 CD 10_1101-2021_01_06_425584 686 141 Sulfur Sulfur NNP 10_1101-2021_01_06_425584 686 142 amino amino NN 10_1101-2021_01_06_425584 686 143 acid acid NN 10_1101-2021_01_06_425584 686 144 metabolism metabolism VBG 10_1101-2021_01_06_425584 686 145 25 25 CD 10_1101-2021_01_06_425584 686 146 9 9 CD 10_1101-2021_01_06_425584 686 147 9.84E-09 9.84e-09 CD 10_1101-2021_01_06_425584 686 148 Drug Drug NNP 10_1101-2021_01_06_425584 686 149 metabolism metabolism NN 10_1101-2021_01_06_425584 686 150 - - HYPH 10_1101-2021_01_06_425584 686 151 other other JJ 10_1101-2021_01_06_425584 686 152 enzymes enzyme NNS 10_1101-2021_01_06_425584 686 153 79 79 CD 10_1101-2021_01_06_425584 686 154 20 20 CD 10_1101-2021_01_06_425584 686 155 2.45E- 2.45e- CD 10_1101-2021_01_06_425584 686 156 16 16 CD 10_1101-2021_01_06_425584 686 157 Tryptophan Tryptophan NNP 10_1101-2021_01_06_425584 686 158 catabolism catabolism NN 10_1101-2021_01_06_425584 686 159 11 11 CD 10_1101-2021_01_06_425584 686 160 6 6 CD 10_1101-2021_01_06_425584 686 161 7.51E-07 7.51e-07 CD 10_1101-2021_01_06_425584 686 162 mRNA mrna NN 10_1101-2021_01_06_425584 686 163 surveillance surveillance NN 10_1101-2021_01_06_425584 686 164 pathway pathway VBD 10_1101-2021_01_06_425584 686 165 73 73 CD 10_1101-2021_01_06_425584 686 166 19 19 CD 10_1101-2021_01_06_425584 686 167 8.78E- 8.78e- CD 10_1101-2021_01_06_425584 686 168 16 16 CD