id sid tid token lemma pos 10_1101-2021_01_04_425177 1 1 The the DT 10_1101-2021_01_04_425177 1 2 engineered engineer VBN 10_1101-2021_01_04_425177 1 3 peptide peptide NN 10_1101-2021_01_04_425177 1 4 construct construct NN 10_1101-2021_01_04_425177 1 5 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 1 6 inhibits inhibit VBZ 10_1101-2021_01_04_425177 1 7 aggregation aggregation NN 10_1101-2021_01_04_425177 1 8 of of IN 10_1101-2021_01_04_425177 1 9 the the DT 10_1101-2021_01_04_425177 1 10 human human JJ 10_1101-2021_01_04_425177 1 11 prion prion NN 10_1101-2021_01_04_425177 1 12 protein protein NN 10_1101-2021_01_04_425177 1 13 ( ( -LRB- 10_1101-2021_01_04_425177 1 14 PrP PrP NNP 10_1101-2021_01_04_425177 1 15 ) ) -RRB- 10_1101-2021_01_04_425177 1 16 1 1 CD 10_1101-2021_01_04_425177 1 17 The the DT 10_1101-2021_01_04_425177 1 18 engineered engineer VBN 10_1101-2021_01_04_425177 1 19 peptide peptide NN 10_1101-2021_01_04_425177 1 20 construct construct NN 10_1101-2021_01_04_425177 1 21 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 1 22 inhibits inhibit VBZ 10_1101-2021_01_04_425177 1 23 aggregation aggregation NN 10_1101-2021_01_04_425177 1 24 of of IN 10_1101-2021_01_04_425177 1 25 the the DT 10_1101-2021_01_04_425177 1 26 human human JJ 10_1101-2021_01_04_425177 1 27 prion prion NN 10_1101-2021_01_04_425177 1 28 protein protein NN 10_1101-2021_01_04_425177 1 29 ( ( -LRB- 10_1101-2021_01_04_425177 1 30 PrP PrP NNP 10_1101-2021_01_04_425177 1 31 ) ) -RRB- 10_1101-2021_01_04_425177 1 32 Maciej Maciej NNP 10_1101-2021_01_04_425177 1 33 Gielnik Gielnik NNP 10_1101-2021_01_04_425177 1 34 1 1 CD 10_1101-2021_01_04_425177 1 35 , , , 10_1101-2021_01_04_425177 1 36 Lilia Lilia NNP 10_1101-2021_01_04_425177 1 37 Zhukova Zhukova NNP 10_1101-2021_01_04_425177 1 38 2 2 CD 10_1101-2021_01_04_425177 1 39 , , , 10_1101-2021_01_04_425177 1 40 Igor Igor NNP 10_1101-2021_01_04_425177 1 41 Zhukov Zhukov NNP 10_1101-2021_01_04_425177 1 42 2 2 CD 10_1101-2021_01_04_425177 1 43 , , , 10_1101-2021_01_04_425177 1 44 Astrid Astrid NNP 10_1101-2021_01_04_425177 1 45 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 1 46 3 3 CD 10_1101-2021_01_04_425177 1 47 , , , 10_1101-2021_01_04_425177 1 48 Maciej Maciej NNP 10_1101-2021_01_04_425177 1 49 Kozak Kozak NNP 10_1101-2021_01_04_425177 1 50 1,4 1,4 CD 10_1101-2021_01_04_425177 1 51 , , , 10_1101-2021_01_04_425177 1 52 Sebastian Sebastian NNP 10_1101-2021_01_04_425177 1 53 K.T.S. K.T.S. NNP 10_1101-2021_01_04_425177 2 1 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 2 2 3 3 CD 10_1101-2021_01_04_425177 2 3 , , , 10_1101-2021_01_04_425177 2 4 * * NFP 10_1101-2021_01_04_425177 2 5 1 1 CD 10_1101-2021_01_04_425177 2 6 Department Department NNP 10_1101-2021_01_04_425177 2 7 of of IN 10_1101-2021_01_04_425177 2 8 Macromolecular Macromolecular NNP 10_1101-2021_01_04_425177 2 9 Physics Physics NNP 10_1101-2021_01_04_425177 2 10 , , , 10_1101-2021_01_04_425177 2 11 Adam Adam NNP 10_1101-2021_01_04_425177 2 12 Mickiewicz Mickiewicz NNP 10_1101-2021_01_04_425177 2 13 University University NNP 10_1101-2021_01_04_425177 2 14 , , , 10_1101-2021_01_04_425177 2 15 Poznań Poznań NNP 10_1101-2021_01_04_425177 2 16 , , , 10_1101-2021_01_04_425177 2 17 Poland Poland NNP 10_1101-2021_01_04_425177 2 18 ; ; : 10_1101-2021_01_04_425177 2 19 maciejgielnik@amu.edu.pl maciejgielnik@amu.edu.pl NNP 10_1101-2021_01_04_425177 2 20 ( ( -LRB- 10_1101-2021_01_04_425177 2 21 M.G. M.G. NNP 10_1101-2021_01_04_425177 3 1 ) ) -RRB- 10_1101-2021_01_04_425177 3 2 ; ; : 10_1101-2021_01_04_425177 3 3 mkozak@amu.edu.pl mkozak@amu.edu.pl NNP 10_1101-2021_01_04_425177 3 4 ( ( -LRB- 10_1101-2021_01_04_425177 3 5 M.K. M.K. NNP 10_1101-2021_01_04_425177 3 6 ) ) -RRB- 10_1101-2021_01_04_425177 4 1 2 2 CD 10_1101-2021_01_04_425177 4 2 Institute Institute NNP 10_1101-2021_01_04_425177 4 3 of of IN 10_1101-2021_01_04_425177 4 4 Biochemistry Biochemistry NNP 10_1101-2021_01_04_425177 4 5 and and CC 10_1101-2021_01_04_425177 4 6 Biophysics Biophysics NNPS 10_1101-2021_01_04_425177 4 7 , , , 10_1101-2021_01_04_425177 4 8 Polish Polish NNP 10_1101-2021_01_04_425177 4 9 Academy Academy NNP 10_1101-2021_01_04_425177 4 10 of of IN 10_1101-2021_01_04_425177 4 11 Sciences Sciences NNPS 10_1101-2021_01_04_425177 4 12 , , , 10_1101-2021_01_04_425177 4 13 Warszawa Warszawa NNP 10_1101-2021_01_04_425177 4 14 , , , 10_1101-2021_01_04_425177 4 15 Poland Poland NNP 10_1101-2021_01_04_425177 4 16 ; ; : 10_1101-2021_01_04_425177 4 17 lilia@ibb.waw.pl lilia@ibb.waw.pl NNP 10_1101-2021_01_04_425177 4 18 ( ( -LRB- 10_1101-2021_01_04_425177 4 19 L.Z. L.Z. NNP 10_1101-2021_01_04_425177 5 1 ) ) -RRB- 10_1101-2021_01_04_425177 5 2 ; ; : 10_1101-2021_01_04_425177 5 3 igor@ibb.waw.pl igor@ibb.waw.pl NNP 10_1101-2021_01_04_425177 5 4 ( ( -LRB- 10_1101-2021_01_04_425177 5 5 I.Z. I.Z. NNP 10_1101-2021_01_04_425177 5 6 ) ) -RRB- 10_1101-2021_01_04_425177 6 1 3 3 CD 10_1101-2021_01_04_425177 6 2 Department Department NNP 10_1101-2021_01_04_425177 6 3 of of IN 10_1101-2021_01_04_425177 6 4 Biochemistry Biochemistry NNP 10_1101-2021_01_04_425177 6 5 and and CC 10_1101-2021_01_04_425177 6 6 Biophysics Biophysics NNPS 10_1101-2021_01_04_425177 6 7 , , , 10_1101-2021_01_04_425177 6 8 Arrhenius Arrhenius NNP 10_1101-2021_01_04_425177 6 9 Laboratories Laboratories NNP 10_1101-2021_01_04_425177 6 10 , , , 10_1101-2021_01_04_425177 6 11 Stockholm Stockholm NNP 10_1101-2021_01_04_425177 6 12 University University NNP 10_1101-2021_01_04_425177 6 13 , , , 10_1101-2021_01_04_425177 6 14 106 106 CD 10_1101-2021_01_04_425177 6 15 91 91 CD 10_1101-2021_01_04_425177 6 16 Stockholm Stockholm NNP 10_1101-2021_01_04_425177 6 17 , , , 10_1101-2021_01_04_425177 6 18 Sweden Sweden NNP 10_1101-2021_01_04_425177 6 19 ; ; : 10_1101-2021_01_04_425177 6 20 astrid@dbb.su.se astrid@dbb.su.se NN 10_1101-2021_01_04_425177 6 21 ( ( -LRB- 10_1101-2021_01_04_425177 6 22 A.G. A.G. NNP 10_1101-2021_01_04_425177 6 23 ) ) -RRB- 10_1101-2021_01_04_425177 6 24 ; ; : 10_1101-2021_01_04_425177 6 25 seb@dbb.su.se seb@dbb.su.se NNP 10_1101-2021_01_04_425177 6 26 ( ( -LRB- 10_1101-2021_01_04_425177 6 27 S.W. S.W. NNP 10_1101-2021_01_04_425177 6 28 ) ) -RRB- 10_1101-2021_01_04_425177 7 1 4 4 CD 10_1101-2021_01_04_425177 7 2 National National NNP 10_1101-2021_01_04_425177 7 3 Synchrotron Synchrotron NNP 10_1101-2021_01_04_425177 7 4 Radiation Radiation NNP 10_1101-2021_01_04_425177 7 5 Centre Centre NNP 10_1101-2021_01_04_425177 7 6 SOLARIS SOLARIS NNP 10_1101-2021_01_04_425177 7 7 , , , 10_1101-2021_01_04_425177 7 8 Jagiellonian Jagiellonian NNP 10_1101-2021_01_04_425177 7 9 University University NNP 10_1101-2021_01_04_425177 7 10 , , , 10_1101-2021_01_04_425177 7 11 Kraków Kraków NNP 10_1101-2021_01_04_425177 7 12 , , , 10_1101-2021_01_04_425177 7 13 Poland Poland NNP 10_1101-2021_01_04_425177 7 14 . . . 10_1101-2021_01_04_425177 8 1 * * NFP 10_1101-2021_01_04_425177 8 2 Correspondence correspondence NN 10_1101-2021_01_04_425177 8 3 : : : 10_1101-2021_01_04_425177 8 4 seb@dbb.su.se seb@dbb.su.se NN 10_1101-2021_01_04_425177 8 5 ; ; : 10_1101-2021_01_04_425177 8 6 Tel Tel NNP 10_1101-2021_01_04_425177 8 7 . . . 10_1101-2021_01_04_425177 9 1 : : : 10_1101-2021_01_04_425177 9 2 +46 +46 CD 10_1101-2021_01_04_425177 9 3 - - HYPH 10_1101-2021_01_04_425177 9 4 8 8 CD 10_1101-2021_01_04_425177 9 5 - - SYM 10_1101-2021_01_04_425177 9 6 16 16 CD 10_1101-2021_01_04_425177 9 7 24 24 CD 10_1101-2021_01_04_425177 9 8 44 44 CD 10_1101-2021_01_04_425177 9 9 Abstract Abstract NNP 10_1101-2021_01_04_425177 9 10 : : : 10_1101-2021_01_04_425177 9 11 In in IN 10_1101-2021_01_04_425177 9 12 prion prion NN 10_1101-2021_01_04_425177 9 13 diseases disease NNS 10_1101-2021_01_04_425177 9 14 , , , 10_1101-2021_01_04_425177 9 15 the the DT 10_1101-2021_01_04_425177 9 16 prion prion NN 10_1101-2021_01_04_425177 9 17 protein protein NN 10_1101-2021_01_04_425177 9 18 ( ( -LRB- 10_1101-2021_01_04_425177 9 19 PrP PrP NNP 10_1101-2021_01_04_425177 9 20 ) ) -RRB- 10_1101-2021_01_04_425177 9 21 becomes become VBZ 10_1101-2021_01_04_425177 9 22 misfolded misfolded JJ 10_1101-2021_01_04_425177 9 23 and and CC 10_1101-2021_01_04_425177 9 24 forms form NNS 10_1101-2021_01_04_425177 9 25 fibrillar fibrillar JJ 10_1101-2021_01_04_425177 9 26 aggregates aggregate NNS 10_1101-2021_01_04_425177 9 27 , , , 10_1101-2021_01_04_425177 9 28 which which WDT 10_1101-2021_01_04_425177 9 29 are be VBP 10_1101-2021_01_04_425177 9 30 resistant resistant JJ 10_1101-2021_01_04_425177 9 31 to to TO 10_1101-2021_01_04_425177 9 32 proteinase proteinase VB 10_1101-2021_01_04_425177 9 33 degradation degradation NN 10_1101-2021_01_04_425177 9 34 and and CC 10_1101-2021_01_04_425177 9 35 become become VB 10_1101-2021_01_04_425177 9 36 responsible responsible JJ 10_1101-2021_01_04_425177 9 37 for for IN 10_1101-2021_01_04_425177 9 38 prion prion NN 10_1101-2021_01_04_425177 9 39 infectivity infectivity NN 10_1101-2021_01_04_425177 9 40 and and CC 10_1101-2021_01_04_425177 9 41 pathology pathology NN 10_1101-2021_01_04_425177 9 42 . . . 10_1101-2021_01_04_425177 10 1 So so RB 10_1101-2021_01_04_425177 10 2 far far RB 10_1101-2021_01_04_425177 10 3 , , , 10_1101-2021_01_04_425177 10 4 no no DT 10_1101-2021_01_04_425177 10 5 drug drug NN 10_1101-2021_01_04_425177 10 6 or or CC 10_1101-2021_01_04_425177 10 7 treatment treatment NN 10_1101-2021_01_04_425177 10 8 procedures procedure NNS 10_1101-2021_01_04_425177 10 9 have have VBP 10_1101-2021_01_04_425177 10 10 been be VBN 10_1101-2021_01_04_425177 10 11 approved approve VBN 10_1101-2021_01_04_425177 10 12 for for IN 10_1101-2021_01_04_425177 10 13 prion prion NN 10_1101-2021_01_04_425177 10 14 disease disease NN 10_1101-2021_01_04_425177 10 15 treatment treatment NN 10_1101-2021_01_04_425177 10 16 . . . 10_1101-2021_01_04_425177 11 1 We -PRON- PRP 10_1101-2021_01_04_425177 11 2 have have VBP 10_1101-2021_01_04_425177 11 3 previously previously RB 10_1101-2021_01_04_425177 11 4 shown show VBN 10_1101-2021_01_04_425177 11 5 that that IN 10_1101-2021_01_04_425177 11 6 engineered engineer VBN 10_1101-2021_01_04_425177 11 7 cell cell NN 10_1101-2021_01_04_425177 11 8 - - HYPH 10_1101-2021_01_04_425177 11 9 penetrating penetrate VBG 10_1101-2021_01_04_425177 11 10 peptide peptide NN 10_1101-2021_01_04_425177 11 11 constructs construct NNS 10_1101-2021_01_04_425177 11 12 can can MD 10_1101-2021_01_04_425177 11 13 reduce reduce VB 10_1101-2021_01_04_425177 11 14 the the DT 10_1101-2021_01_04_425177 11 15 amount amount NN 10_1101-2021_01_04_425177 11 16 of of IN 10_1101-2021_01_04_425177 11 17 prion prion NN 10_1101-2021_01_04_425177 11 18 aggregates aggregate NNS 10_1101-2021_01_04_425177 11 19 in in IN 10_1101-2021_01_04_425177 11 20 infected infected JJ 10_1101-2021_01_04_425177 11 21 cells cell NNS 10_1101-2021_01_04_425177 11 22 . . . 10_1101-2021_01_04_425177 12 1 The the DT 10_1101-2021_01_04_425177 12 2 molecular molecular JJ 10_1101-2021_01_04_425177 12 3 mechanisms mechanism NNS 10_1101-2021_01_04_425177 12 4 underlying underlie VBG 10_1101-2021_01_04_425177 12 5 this this DT 10_1101-2021_01_04_425177 12 6 effect effect NN 10_1101-2021_01_04_425177 12 7 are be VBP 10_1101-2021_01_04_425177 12 8 however however RB 10_1101-2021_01_04_425177 12 9 unknown unknown JJ 10_1101-2021_01_04_425177 12 10 . . . 10_1101-2021_01_04_425177 13 1 Here here RB 10_1101-2021_01_04_425177 13 2 , , , 10_1101-2021_01_04_425177 13 3 we -PRON- PRP 10_1101-2021_01_04_425177 13 4 use use VBP 10_1101-2021_01_04_425177 13 5 atomic atomic JJ 10_1101-2021_01_04_425177 13 6 force force NN 10_1101-2021_01_04_425177 13 7 microscopy microscopy JJ 10_1101-2021_01_04_425177 13 8 ( ( -LRB- 10_1101-2021_01_04_425177 13 9 AFM AFM NNP 10_1101-2021_01_04_425177 13 10 ) ) -RRB- 10_1101-2021_01_04_425177 13 11 imaging image VBG 10_1101-2021_01_04_425177 13 12 to to TO 10_1101-2021_01_04_425177 13 13 show show VB 10_1101-2021_01_04_425177 13 14 that that IN 10_1101-2021_01_04_425177 13 15 the the DT 10_1101-2021_01_04_425177 13 16 aggregation aggregation NN 10_1101-2021_01_04_425177 13 17 of of IN 10_1101-2021_01_04_425177 13 18 the the DT 10_1101-2021_01_04_425177 13 19 human human JJ 10_1101-2021_01_04_425177 13 20 PrP PrP NNP 10_1101-2021_01_04_425177 13 21 protein protein NN 10_1101-2021_01_04_425177 13 22 can can MD 10_1101-2021_01_04_425177 13 23 be be VB 10_1101-2021_01_04_425177 13 24 inhibited inhibit VBN 10_1101-2021_01_04_425177 13 25 by by IN 10_1101-2021_01_04_425177 13 26 equimolar equimolar JJ 10_1101-2021_01_04_425177 13 27 amounts amount NNS 10_1101-2021_01_04_425177 13 28 of of IN 10_1101-2021_01_04_425177 13 29 the the DT 10_1101-2021_01_04_425177 13 30 25 25 CD 10_1101-2021_01_04_425177 13 31 residues residue NNS 10_1101-2021_01_04_425177 13 32 long long RB 10_1101-2021_01_04_425177 13 33 engineered engineer VBN 10_1101-2021_01_04_425177 13 34 peptide peptide NN 10_1101-2021_01_04_425177 13 35 construct construct NN 10_1101-2021_01_04_425177 13 36 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 13 37 . . . 10_1101-2021_01_04_425177 14 1 Keywords keyword NNS 10_1101-2021_01_04_425177 14 2 : : : 10_1101-2021_01_04_425177 14 3 Creutzfeldt Creutzfeldt NNP 10_1101-2021_01_04_425177 14 4 - - HYPH 10_1101-2021_01_04_425177 14 5 Jakob Jakob NNP 10_1101-2021_01_04_425177 14 6 disease disease NN 10_1101-2021_01_04_425177 14 7 ; ; : 10_1101-2021_01_04_425177 14 8 AFM AFM NNP 10_1101-2021_01_04_425177 14 9 imaging imaging NN 10_1101-2021_01_04_425177 14 10 ; ; : 10_1101-2021_01_04_425177 14 11 amyloid amyloid NN 10_1101-2021_01_04_425177 14 12 ; ; : 10_1101-2021_01_04_425177 14 13 drug drug NN 10_1101-2021_01_04_425177 14 14 design design NN 10_1101-2021_01_04_425177 14 15 ; ; : 10_1101-2021_01_04_425177 14 16 drug drug NN 10_1101-2021_01_04_425177 14 17 transport transport NN 10_1101-2021_01_04_425177 14 18 ; ; : 10_1101-2021_01_04_425177 14 19 protein protein NN 10_1101-2021_01_04_425177 14 20 - - HYPH 10_1101-2021_01_04_425177 14 21 peptide peptide NN 10_1101-2021_01_04_425177 14 22 binding binding NN 10_1101-2021_01_04_425177 14 23 .CC .CC : 10_1101-2021_01_04_425177 14 24 - - HYPH 10_1101-2021_01_04_425177 14 25 BY by IN 10_1101-2021_01_04_425177 14 26 - - HYPH 10_1101-2021_01_04_425177 14 27 NC NC NNP 10_1101-2021_01_04_425177 14 28 - - HYPH 10_1101-2021_01_04_425177 14 29 ND ND NNP 10_1101-2021_01_04_425177 14 30 4.0 4.0 CD 10_1101-2021_01_04_425177 14 31 International international JJ 10_1101-2021_01_04_425177 14 32 licensemade licensemade NN 10_1101-2021_01_04_425177 14 33 available available JJ 10_1101-2021_01_04_425177 14 34 under under IN 10_1101-2021_01_04_425177 14 35 a a DT 10_1101-2021_01_04_425177 14 36 ( ( -LRB- 10_1101-2021_01_04_425177 14 37 which which WDT 10_1101-2021_01_04_425177 14 38 was be VBD 10_1101-2021_01_04_425177 14 39 not not RB 10_1101-2021_01_04_425177 14 40 certified certify VBN 10_1101-2021_01_04_425177 14 41 by by IN 10_1101-2021_01_04_425177 14 42 peer peer NN 10_1101-2021_01_04_425177 14 43 review review NN 10_1101-2021_01_04_425177 14 44 ) ) -RRB- 10_1101-2021_01_04_425177 14 45 is be VBZ 10_1101-2021_01_04_425177 14 46 the the DT 10_1101-2021_01_04_425177 14 47 author author NN 10_1101-2021_01_04_425177 14 48 / / SYM 10_1101-2021_01_04_425177 14 49 funder funder NN 10_1101-2021_01_04_425177 14 50 , , , 10_1101-2021_01_04_425177 14 51 who who WP 10_1101-2021_01_04_425177 14 52 has have VBZ 10_1101-2021_01_04_425177 14 53 granted grant VBN 10_1101-2021_01_04_425177 14 54 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 14 55 a a DT 10_1101-2021_01_04_425177 14 56 license license NN 10_1101-2021_01_04_425177 14 57 to to TO 10_1101-2021_01_04_425177 14 58 display display VB 10_1101-2021_01_04_425177 14 59 the the DT 10_1101-2021_01_04_425177 14 60 preprint preprint NN 10_1101-2021_01_04_425177 14 61 in in IN 10_1101-2021_01_04_425177 14 62 perpetuity perpetuity NN 10_1101-2021_01_04_425177 14 63 . . . 10_1101-2021_01_04_425177 15 1 It -PRON- PRP 10_1101-2021_01_04_425177 15 2 is be VBZ 10_1101-2021_01_04_425177 15 3 The the DT 10_1101-2021_01_04_425177 15 4 copyright copyright NN 10_1101-2021_01_04_425177 15 5 holder holder NN 10_1101-2021_01_04_425177 15 6 for for IN 10_1101-2021_01_04_425177 15 7 this this DT 10_1101-2021_01_04_425177 15 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 15 9 version version NN 10_1101-2021_01_04_425177 15 10 posted post VBD 10_1101-2021_01_04_425177 15 11 January January NNP 10_1101-2021_01_04_425177 15 12 4 4 CD 10_1101-2021_01_04_425177 15 13 , , , 10_1101-2021_01_04_425177 15 14 2021 2021 CD 10_1101-2021_01_04_425177 15 15 . . . 10_1101-2021_01_04_425177 15 16 ; ; : 10_1101-2021_01_04_425177 15 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 15 18 : : : 10_1101-2021_01_04_425177 15 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 15 20 preprint preprint NN 10_1101-2021_01_04_425177 15 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 VBZ 10_1101-2021_01_04_425177 15 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_04_425177 15 23 2 2 CD 10_1101-2021_01_04_425177 15 24 1 1 CD 10_1101-2021_01_04_425177 15 25 . . . 10_1101-2021_01_04_425177 16 1 Introduction introduction NN 10_1101-2021_01_04_425177 16 2 Prion prion NN 10_1101-2021_01_04_425177 16 3 and and CC 10_1101-2021_01_04_425177 16 4 amyloid amyloid NN 10_1101-2021_01_04_425177 16 5 diseases disease NNS 10_1101-2021_01_04_425177 16 6 are be VBP 10_1101-2021_01_04_425177 16 7 both both DT 10_1101-2021_01_04_425177 16 8 characterized characterize VBN 10_1101-2021_01_04_425177 16 9 by by IN 10_1101-2021_01_04_425177 16 10 aggregation aggregation NN 10_1101-2021_01_04_425177 16 11 of of IN 10_1101-2021_01_04_425177 16 12 misfolded misfolde VBN 10_1101-2021_01_04_425177 16 13 proteins protein NNS 10_1101-2021_01_04_425177 16 14 or or CC 10_1101-2021_01_04_425177 16 15 peptides peptide NNS 10_1101-2021_01_04_425177 16 16 ( ( -LRB- 10_1101-2021_01_04_425177 16 17 Jaunmuktane Jaunmuktane NNP 10_1101-2021_01_04_425177 16 18 and and CC 10_1101-2021_01_04_425177 16 19 Brandner Brandner NNP 10_1101-2021_01_04_425177 16 20 , , , 10_1101-2021_01_04_425177 16 21 2019 2019 CD 10_1101-2021_01_04_425177 16 22 ; ; : 10_1101-2021_01_04_425177 16 23 Miller Miller NNP 10_1101-2021_01_04_425177 16 24 , , , 10_1101-2021_01_04_425177 16 25 2009 2009 CD 10_1101-2021_01_04_425177 16 26 ; ; : 10_1101-2021_01_04_425177 16 27 Sengupta Sengupta NNP 10_1101-2021_01_04_425177 16 28 and and CC 10_1101-2021_01_04_425177 16 29 Udgaonkar Udgaonkar NNP 10_1101-2021_01_04_425177 16 30 , , , 10_1101-2021_01_04_425177 16 31 2018 2018 CD 10_1101-2021_01_04_425177 16 32 ; ; : 10_1101-2021_01_04_425177 16 33 Verma Verma NNP 10_1101-2021_01_04_425177 16 34 et et FW 10_1101-2021_01_04_425177 16 35 al al NNP 10_1101-2021_01_04_425177 16 36 . . NNP 10_1101-2021_01_04_425177 16 37 , , , 10_1101-2021_01_04_425177 16 38 2015 2015 CD 10_1101-2021_01_04_425177 16 39 ) ) -RRB- 10_1101-2021_01_04_425177 16 40 , , , 10_1101-2021_01_04_425177 16 41 such such JJ 10_1101-2021_01_04_425177 16 42 as as IN 10_1101-2021_01_04_425177 16 43 the the DT 10_1101-2021_01_04_425177 16 44 prion prion NN 10_1101-2021_01_04_425177 16 45 ( ( -LRB- 10_1101-2021_01_04_425177 16 46 PrP PrP NNP 10_1101-2021_01_04_425177 16 47 ) ) -RRB- 10_1101-2021_01_04_425177 16 48 protein protein NN 10_1101-2021_01_04_425177 16 49 ( ( -LRB- 10_1101-2021_01_04_425177 16 50 Creutzfeldt- Creutzfeldt- NNP 10_1101-2021_01_04_425177 16 51 Jakob Jakob NNP 10_1101-2021_01_04_425177 16 52 disease disease NN 10_1101-2021_01_04_425177 16 53 ) ) -RRB- 10_1101-2021_01_04_425177 16 54 , , , 10_1101-2021_01_04_425177 16 55 α α NNP 10_1101-2021_01_04_425177 16 56 - - HYPH 10_1101-2021_01_04_425177 16 57 synuclein synuclein NNP 10_1101-2021_01_04_425177 16 58 ( ( -LRB- 10_1101-2021_01_04_425177 16 59 Parkinson Parkinson NNP 10_1101-2021_01_04_425177 16 60 ’s ’s POS 10_1101-2021_01_04_425177 16 61 disease disease NN 10_1101-2021_01_04_425177 16 62 ) ) -RRB- 10_1101-2021_01_04_425177 16 63 , , , 10_1101-2021_01_04_425177 16 64 and and CC 10_1101-2021_01_04_425177 16 65 amyloid amyloid NN 10_1101-2021_01_04_425177 16 66 - - HYPH 10_1101-2021_01_04_425177 16 67 β β NNP 10_1101-2021_01_04_425177 16 68 ( ( -LRB- 10_1101-2021_01_04_425177 16 69 Aβ Aβ NNP 10_1101-2021_01_04_425177 16 70 ) ) -RRB- 10_1101-2021_01_04_425177 16 71 and and CC 10_1101-2021_01_04_425177 16 72 tau tau NNP 10_1101-2021_01_04_425177 16 73 ( ( -LRB- 10_1101-2021_01_04_425177 16 74 Alzheimer Alzheimer NNP 10_1101-2021_01_04_425177 16 75 ’s ’s POS 10_1101-2021_01_04_425177 16 76 disease disease NN 10_1101-2021_01_04_425177 16 77 ) ) -RRB- 10_1101-2021_01_04_425177 16 78 . . . 10_1101-2021_01_04_425177 17 1 Many many JJ 10_1101-2021_01_04_425177 17 2 of of IN 10_1101-2021_01_04_425177 17 3 these these DT 10_1101-2021_01_04_425177 17 4 proteins protein NNS 10_1101-2021_01_04_425177 17 5 and and CC 10_1101-2021_01_04_425177 17 6 peptides peptide NNS 10_1101-2021_01_04_425177 17 7 may may MD 10_1101-2021_01_04_425177 17 8 co co VB 10_1101-2021_01_04_425177 17 9 - - VB 10_1101-2021_01_04_425177 17 10 aggregate aggregate VB 10_1101-2021_01_04_425177 17 11 or or CC 10_1101-2021_01_04_425177 17 12 at at IN 10_1101-2021_01_04_425177 17 13 least least JJS 10_1101-2021_01_04_425177 17 14 influence influence VB 10_1101-2021_01_04_425177 17 15 each each DT 10_1101-2021_01_04_425177 17 16 other other JJ 10_1101-2021_01_04_425177 17 17 ’s ’s POS 10_1101-2021_01_04_425177 17 18 aggregation aggregation NN 10_1101-2021_01_04_425177 17 19 ( ( -LRB- 10_1101-2021_01_04_425177 17 20 Luo Luo NNP 10_1101-2021_01_04_425177 17 21 et et NNP 10_1101-2021_01_04_425177 17 22 al al NNP 10_1101-2021_01_04_425177 17 23 . . NNP 10_1101-2021_01_04_425177 17 24 , , , 10_1101-2021_01_04_425177 17 25 2016 2016 CD 10_1101-2021_01_04_425177 17 26 , , , 10_1101-2021_01_04_425177 17 27 2017 2017 CD 10_1101-2021_01_04_425177 17 28 ; ; : 10_1101-2021_01_04_425177 17 29 Ren Ren NNP 10_1101-2021_01_04_425177 17 30 et et NNP 10_1101-2021_01_04_425177 17 31 al al NNP 10_1101-2021_01_04_425177 17 32 . . NNP 10_1101-2021_01_04_425177 17 33 , , , 10_1101-2021_01_04_425177 17 34 2019 2019 CD 10_1101-2021_01_04_425177 17 35 ; ; : 10_1101-2021_01_04_425177 17 36 Wallin Wallin NNP 10_1101-2021_01_04_425177 17 37 et et NNP 10_1101-2021_01_04_425177 17 38 al al NNP 10_1101-2021_01_04_425177 17 39 . . NNP 10_1101-2021_01_04_425177 17 40 , , , 10_1101-2021_01_04_425177 17 41 2018 2018 CD 10_1101-2021_01_04_425177 17 42 ) ) -RRB- 10_1101-2021_01_04_425177 17 43 . . . 10_1101-2021_01_04_425177 18 1 Factors factor NNS 10_1101-2021_01_04_425177 18 2 that that WDT 10_1101-2021_01_04_425177 18 3 modulate modulate VBP 10_1101-2021_01_04_425177 18 4 the the DT 10_1101-2021_01_04_425177 18 5 aggregation aggregation NN 10_1101-2021_01_04_425177 18 6 of of IN 10_1101-2021_01_04_425177 18 7 one one CD 10_1101-2021_01_04_425177 18 8 of of IN 10_1101-2021_01_04_425177 18 9 these these DT 10_1101-2021_01_04_425177 18 10 proteins protein NNS 10_1101-2021_01_04_425177 18 11 , , , 10_1101-2021_01_04_425177 18 12 such such JJ 10_1101-2021_01_04_425177 18 13 as as IN 10_1101-2021_01_04_425177 18 14 small small JJ 10_1101-2021_01_04_425177 18 15 molecules molecule NNS 10_1101-2021_01_04_425177 18 16 , , , 10_1101-2021_01_04_425177 18 17 potential potential JJ 10_1101-2021_01_04_425177 18 18 drug drug NN 10_1101-2021_01_04_425177 18 19 compounds compound NNS 10_1101-2021_01_04_425177 18 20 , , , 10_1101-2021_01_04_425177 18 21 lipids lipid NNS 10_1101-2021_01_04_425177 18 22 , , , 10_1101-2021_01_04_425177 18 23 and and CC 10_1101-2021_01_04_425177 18 24 metal metal NN 10_1101-2021_01_04_425177 18 25 ions ion NNS 10_1101-2021_01_04_425177 18 26 , , , 10_1101-2021_01_04_425177 18 27 can can MD 10_1101-2021_01_04_425177 18 28 often often RB 10_1101-2021_01_04_425177 18 29 modulate modulate VB 10_1101-2021_01_04_425177 18 30 also also RB 10_1101-2021_01_04_425177 18 31 the the DT 10_1101-2021_01_04_425177 18 32 aggregation aggregation NN 10_1101-2021_01_04_425177 18 33 processes process NNS 10_1101-2021_01_04_425177 18 34 of of IN 10_1101-2021_01_04_425177 18 35 other other JJ 10_1101-2021_01_04_425177 18 36 proteins protein NNS 10_1101-2021_01_04_425177 18 37 in in IN 10_1101-2021_01_04_425177 18 38 this this DT 10_1101-2021_01_04_425177 18 39 family family NN 10_1101-2021_01_04_425177 18 40 ( ( -LRB- 10_1101-2021_01_04_425177 18 41 Ambadi Ambadi NNP 10_1101-2021_01_04_425177 18 42 Thody Thody NNP 10_1101-2021_01_04_425177 18 43 et et FW 10_1101-2021_01_04_425177 18 44 al al NNP 10_1101-2021_01_04_425177 18 45 . . NNP 10_1101-2021_01_04_425177 18 46 , , , 10_1101-2021_01_04_425177 18 47 2018 2018 CD 10_1101-2021_01_04_425177 18 48 ; ; : 10_1101-2021_01_04_425177 18 49 Chemerovski Chemerovski NNP 10_1101-2021_01_04_425177 18 50 - - HYPH 10_1101-2021_01_04_425177 18 51 Glikman Glikman NNP 10_1101-2021_01_04_425177 18 52 et et NNP 10_1101-2021_01_04_425177 18 53 al al NNP 10_1101-2021_01_04_425177 18 54 . . NNP 10_1101-2021_01_04_425177 18 55 , , , 10_1101-2021_01_04_425177 18 56 2016 2016 CD 10_1101-2021_01_04_425177 18 57 ; ; : 10_1101-2021_01_04_425177 18 58 Gielnik Gielnik NNP 10_1101-2021_01_04_425177 18 59 et et FW 10_1101-2021_01_04_425177 18 60 al al NNP 10_1101-2021_01_04_425177 18 61 . . NNP 10_1101-2021_01_04_425177 18 62 , , , 10_1101-2021_01_04_425177 18 63 2019 2019 CD 10_1101-2021_01_04_425177 18 64 ; ; : 10_1101-2021_01_04_425177 18 65 Owen Owen NNP 10_1101-2021_01_04_425177 18 66 et et NNP 10_1101-2021_01_04_425177 18 67 al al NNP 10_1101-2021_01_04_425177 18 68 . . NNP 10_1101-2021_01_04_425177 18 69 , , , 10_1101-2021_01_04_425177 18 70 2019 2019 CD 10_1101-2021_01_04_425177 18 71 ; ; : 10_1101-2021_01_04_425177 18 72 Richman Richman NNP 10_1101-2021_01_04_425177 18 73 et et FW 10_1101-2021_01_04_425177 18 74 al al NNP 10_1101-2021_01_04_425177 18 75 . . NNP 10_1101-2021_01_04_425177 18 76 , , , 10_1101-2021_01_04_425177 18 77 2013 2013 CD 10_1101-2021_01_04_425177 18 78 ; ; : 10_1101-2021_01_04_425177 18 79 Robinson Robinson NNP 10_1101-2021_01_04_425177 18 80 and and CC 10_1101-2021_01_04_425177 18 81 Pinheiro Pinheiro NNP 10_1101-2021_01_04_425177 18 82 , , , 10_1101-2021_01_04_425177 18 83 2010 2010 CD 10_1101-2021_01_04_425177 18 84 ; ; : 10_1101-2021_01_04_425177 18 85 Wallin Wallin NNP 10_1101-2021_01_04_425177 18 86 et et NNP 10_1101-2021_01_04_425177 18 87 al al NNP 10_1101-2021_01_04_425177 18 88 . . NNP 10_1101-2021_01_04_425177 18 89 , , , 10_1101-2021_01_04_425177 18 90 2017 2017 CD 10_1101-2021_01_04_425177 18 91 ; ; : 10_1101-2021_01_04_425177 18 92 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 18 93 et et FW 10_1101-2021_01_04_425177 18 94 al al NNP 10_1101-2021_01_04_425177 18 95 . . NNP 10_1101-2021_01_04_425177 18 96 , , , 10_1101-2021_01_04_425177 18 97 2013 2013 CD 10_1101-2021_01_04_425177 18 98 ; ; : 10_1101-2021_01_04_425177 18 99 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 18 100 et et FW 10_1101-2021_01_04_425177 18 101 al al NNP 10_1101-2021_01_04_425177 18 102 . . NNP 10_1101-2021_01_04_425177 18 103 , , , 10_1101-2021_01_04_425177 18 104 2019 2019 CD 10_1101-2021_01_04_425177 18 105 ; ; : 10_1101-2021_01_04_425177 18 106 Österlund Österlund NNP 10_1101-2021_01_04_425177 18 107 et et NNP 10_1101-2021_01_04_425177 18 108 al al NNP 10_1101-2021_01_04_425177 18 109 . . NNP 10_1101-2021_01_04_425177 18 110 , , , 10_1101-2021_01_04_425177 18 111 2018 2018 CD 10_1101-2021_01_04_425177 18 112 ) ) -RRB- 10_1101-2021_01_04_425177 18 113 . . . 10_1101-2021_01_04_425177 19 1 This this DT 10_1101-2021_01_04_425177 19 2 suggests suggest VBZ 10_1101-2021_01_04_425177 19 3 that that IN 10_1101-2021_01_04_425177 19 4 the the DT 10_1101-2021_01_04_425177 19 5 underlying underlie VBG 10_1101-2021_01_04_425177 19 6 mechanisms mechanism NNS 10_1101-2021_01_04_425177 19 7 may may MD 10_1101-2021_01_04_425177 19 8 be be VB 10_1101-2021_01_04_425177 19 9 the the DT 10_1101-2021_01_04_425177 19 10 same same JJ 10_1101-2021_01_04_425177 19 11 in in IN 10_1101-2021_01_04_425177 19 12 prion prion NN 10_1101-2021_01_04_425177 19 13 and and CC 10_1101-2021_01_04_425177 19 14 amyloid amyloid NN 10_1101-2021_01_04_425177 19 15 diseases disease NNS 10_1101-2021_01_04_425177 19 16 ( ( -LRB- 10_1101-2021_01_04_425177 19 17 Jaunmuktane Jaunmuktane NNP 10_1101-2021_01_04_425177 19 18 and and CC 10_1101-2021_01_04_425177 19 19 Brandner Brandner NNP 10_1101-2021_01_04_425177 19 20 , , , 10_1101-2021_01_04_425177 19 21 2019 2019 CD 10_1101-2021_01_04_425177 19 22 ; ; : 10_1101-2021_01_04_425177 19 23 Jucker Jucker NNP 10_1101-2021_01_04_425177 19 24 and and CC 10_1101-2021_01_04_425177 19 25 Walker Walker NNP 10_1101-2021_01_04_425177 19 26 , , , 10_1101-2021_01_04_425177 19 27 2018 2018 CD 10_1101-2021_01_04_425177 19 28 ; ; : 10_1101-2021_01_04_425177 19 29 Miller Miller NNP 10_1101-2021_01_04_425177 19 30 , , , 10_1101-2021_01_04_425177 19 31 2009 2009 CD 10_1101-2021_01_04_425177 19 32 ) ) -RRB- 10_1101-2021_01_04_425177 19 33 . . . 10_1101-2021_01_04_425177 20 1 Prion prion NN 10_1101-2021_01_04_425177 20 2 aggregates aggregate NNS 10_1101-2021_01_04_425177 20 3 are be VBP 10_1101-2021_01_04_425177 20 4 however however RB 10_1101-2021_01_04_425177 20 5 particularly particularly RB 10_1101-2021_01_04_425177 20 6 infectious infectious JJ 10_1101-2021_01_04_425177 20 7 , , , 10_1101-2021_01_04_425177 20 8 as as IN 10_1101-2021_01_04_425177 20 9 they -PRON- PRP 10_1101-2021_01_04_425177 20 10 spread spread VBD 10_1101-2021_01_04_425177 20 11 between between IN 10_1101-2021_01_04_425177 20 12 cells cell NNS 10_1101-2021_01_04_425177 20 13 ( ( -LRB- 10_1101-2021_01_04_425177 20 14 Jaunmuktane Jaunmuktane NNP 10_1101-2021_01_04_425177 20 15 and and CC 10_1101-2021_01_04_425177 20 16 Brandner Brandner NNP 10_1101-2021_01_04_425177 20 17 , , , 10_1101-2021_01_04_425177 20 18 2019 2019 CD 10_1101-2021_01_04_425177 20 19 ; ; : 10_1101-2021_01_04_425177 20 20 Jucker Jucker NNP 10_1101-2021_01_04_425177 20 21 and and CC 10_1101-2021_01_04_425177 20 22 Walker Walker NNP 10_1101-2021_01_04_425177 20 23 , , , 10_1101-2021_01_04_425177 20 24 2018 2018 CD 10_1101-2021_01_04_425177 20 25 ) ) -RRB- 10_1101-2021_01_04_425177 20 26 , , , 10_1101-2021_01_04_425177 20 27 and and CC 10_1101-2021_01_04_425177 20 28 are be VBP 10_1101-2021_01_04_425177 20 29 not not RB 10_1101-2021_01_04_425177 20 30 degraded degrade VBN 10_1101-2021_01_04_425177 20 31 by by IN 10_1101-2021_01_04_425177 20 32 cellular cellular JJ 10_1101-2021_01_04_425177 20 33 processes process NNS 10_1101-2021_01_04_425177 20 34 such such JJ 10_1101-2021_01_04_425177 20 35 as as IN 10_1101-2021_01_04_425177 20 36 proteinase proteinase NN 10_1101-2021_01_04_425177 20 37 digestion digestion NN 10_1101-2021_01_04_425177 20 38 ( ( -LRB- 10_1101-2021_01_04_425177 20 39 Jaunmuktane Jaunmuktane NNP 10_1101-2021_01_04_425177 20 40 and and CC 10_1101-2021_01_04_425177 20 41 Brandner Brandner NNP 10_1101-2021_01_04_425177 20 42 , , , 10_1101-2021_01_04_425177 20 43 2019 2019 CD 10_1101-2021_01_04_425177 20 44 ; ; : 10_1101-2021_01_04_425177 20 45 Löfgren Löfgren NNP 10_1101-2021_01_04_425177 20 46 et et NNP 10_1101-2021_01_04_425177 20 47 al al NNP 10_1101-2021_01_04_425177 20 48 . . NNP 10_1101-2021_01_04_425177 20 49 , , , 10_1101-2021_01_04_425177 20 50 2008 2008 CD 10_1101-2021_01_04_425177 20 51 ; ; : 10_1101-2021_01_04_425177 20 52 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 20 53 et et NNP 10_1101-2021_01_04_425177 20 54 al al NNP 10_1101-2021_01_04_425177 20 55 . . NNP 10_1101-2021_01_04_425177 20 56 , , , 10_1101-2021_01_04_425177 20 57 2014 2014 CD 10_1101-2021_01_04_425177 20 58 ) ) -RRB- 10_1101-2021_01_04_425177 20 59 . . . 10_1101-2021_01_04_425177 21 1 The the DT 10_1101-2021_01_04_425177 21 2 toxic toxic JJ 10_1101-2021_01_04_425177 21 3 species specie NNS 10_1101-2021_01_04_425177 21 4 in in IN 10_1101-2021_01_04_425177 21 5 amyloid amyloid NN 10_1101-2021_01_04_425177 21 6 and and CC 10_1101-2021_01_04_425177 21 7 prion prion NN 10_1101-2021_01_04_425177 21 8 diseases disease NNS 10_1101-2021_01_04_425177 21 9 are be VBP 10_1101-2021_01_04_425177 21 10 generally generally RB 10_1101-2021_01_04_425177 21 11 considered consider VBN 10_1101-2021_01_04_425177 21 12 to to TO 10_1101-2021_01_04_425177 21 13 be be VB 10_1101-2021_01_04_425177 21 14 small small JJ 10_1101-2021_01_04_425177 21 15 toxic toxic JJ 10_1101-2021_01_04_425177 21 16 oligomeric oligomeric JJ 10_1101-2021_01_04_425177 21 17 aggregates aggregate NNS 10_1101-2021_01_04_425177 21 18 ( ( -LRB- 10_1101-2021_01_04_425177 21 19 Sengupta Sengupta NNP 10_1101-2021_01_04_425177 21 20 and and CC 10_1101-2021_01_04_425177 21 21 Udgaonkar Udgaonkar NNP 10_1101-2021_01_04_425177 21 22 , , , 10_1101-2021_01_04_425177 21 23 2018 2018 CD 10_1101-2021_01_04_425177 21 24 ; ; : 10_1101-2021_01_04_425177 21 25 Verma Verma NNP 10_1101-2021_01_04_425177 21 26 et et FW 10_1101-2021_01_04_425177 21 27 al al NNP 10_1101-2021_01_04_425177 21 28 . . NNP 10_1101-2021_01_04_425177 21 29 , , , 10_1101-2021_01_04_425177 21 30 2015 2015 CD 10_1101-2021_01_04_425177 21 31 ) ) -RRB- 10_1101-2021_01_04_425177 21 32 , , , 10_1101-2021_01_04_425177 21 33 but but CC 10_1101-2021_01_04_425177 21 34 so so RB 10_1101-2021_01_04_425177 21 35 far far RB 10_1101-2021_01_04_425177 21 36 no no DT 10_1101-2021_01_04_425177 21 37 drugs drug NNS 10_1101-2021_01_04_425177 21 38 or or CC 10_1101-2021_01_04_425177 21 39 treatments treatment NNS 10_1101-2021_01_04_425177 21 40 that that WDT 10_1101-2021_01_04_425177 21 41 target target VBP 10_1101-2021_01_04_425177 21 42 such such JJ 10_1101-2021_01_04_425177 21 43 aggregates aggregate NNS 10_1101-2021_01_04_425177 21 44 have have VBP 10_1101-2021_01_04_425177 21 45 been be VBN 10_1101-2021_01_04_425177 21 46 approved approve VBN 10_1101-2021_01_04_425177 21 47 against against IN 10_1101-2021_01_04_425177 21 48 prion prion NN 10_1101-2021_01_04_425177 21 49 diseases disease NNS 10_1101-2021_01_04_425177 21 50 ( ( -LRB- 10_1101-2021_01_04_425177 21 51 Hyeon Hyeon NNP 10_1101-2021_01_04_425177 21 52 et et NNP 10_1101-2021_01_04_425177 21 53 al al NNP 10_1101-2021_01_04_425177 21 54 . . NNP 10_1101-2021_01_04_425177 21 55 , , , 10_1101-2021_01_04_425177 21 56 2020 2020 CD 10_1101-2021_01_04_425177 21 57 ; ; : 10_1101-2021_01_04_425177 21 58 Lee Lee NNP 10_1101-2021_01_04_425177 21 59 et et FW 10_1101-2021_01_04_425177 21 60 al al NNP 10_1101-2021_01_04_425177 21 61 . . NNP 10_1101-2021_01_04_425177 21 62 , , , 10_1101-2021_01_04_425177 21 63 2019 2019 CD 10_1101-2021_01_04_425177 21 64 ; ; : 10_1101-2021_01_04_425177 21 65 Mashima Mashima NNP 10_1101-2021_01_04_425177 21 66 et et NNP 10_1101-2021_01_04_425177 21 67 al al NNP 10_1101-2021_01_04_425177 21 68 . . NNP 10_1101-2021_01_04_425177 21 69 , , , 10_1101-2021_01_04_425177 21 70 2020 2020 CD 10_1101-2021_01_04_425177 21 71 ) ) -RRB- 10_1101-2021_01_04_425177 21 72 . . . 10_1101-2021_01_04_425177 22 1 Potential potential JJ 10_1101-2021_01_04_425177 22 2 drug drug NN 10_1101-2021_01_04_425177 22 3 molecules molecule NNS 10_1101-2021_01_04_425177 22 4 may may MD 10_1101-2021_01_04_425177 22 5 interfere interfere VB 10_1101-2021_01_04_425177 22 6 with with IN 10_1101-2021_01_04_425177 22 7 oligomer oligomer JJ 10_1101-2021_01_04_425177 22 8 formation formation NN 10_1101-2021_01_04_425177 22 9 in in IN 10_1101-2021_01_04_425177 22 10 various various JJ 10_1101-2021_01_04_425177 22 11 ways way NNS 10_1101-2021_01_04_425177 22 12 : : : 10_1101-2021_01_04_425177 22 13 by by IN 10_1101-2021_01_04_425177 22 14 reducing reduce VBG 10_1101-2021_01_04_425177 22 15 production production NN 10_1101-2021_01_04_425177 22 16 of of IN 10_1101-2021_01_04_425177 22 17 the the DT 10_1101-2021_01_04_425177 22 18 protein protein NN 10_1101-2021_01_04_425177 22 19 , , , 10_1101-2021_01_04_425177 22 20 by by IN 10_1101-2021_01_04_425177 22 21 inhibiting inhibit VBG 10_1101-2021_01_04_425177 22 22 its -PRON- PRP$ 10_1101-2021_01_04_425177 22 23 aggregation aggregation NN 10_1101-2021_01_04_425177 22 24 , , , 10_1101-2021_01_04_425177 22 25 by by IN 10_1101-2021_01_04_425177 22 26 diverting divert VBG 10_1101-2021_01_04_425177 22 27 the the DT 10_1101-2021_01_04_425177 22 28 aggregation aggregation NN 10_1101-2021_01_04_425177 22 29 pathway(s pathway(s NNP 10_1101-2021_01_04_425177 22 30 ) ) -RRB- 10_1101-2021_01_04_425177 22 31 towards towards IN 10_1101-2021_01_04_425177 22 32 non non JJ 10_1101-2021_01_04_425177 22 33 - - JJ 10_1101-2021_01_04_425177 22 34 toxic toxic JJ 10_1101-2021_01_04_425177 22 35 forms form NNS 10_1101-2021_01_04_425177 22 36 , , , 10_1101-2021_01_04_425177 22 37 or or CC 10_1101-2021_01_04_425177 22 38 by by IN 10_1101-2021_01_04_425177 22 39 reducing reduce VBG 10_1101-2021_01_04_425177 22 40 the the DT 10_1101-2021_01_04_425177 22 41 lifetime lifetime NN 10_1101-2021_01_04_425177 22 42 of of IN 10_1101-2021_01_04_425177 22 43 the the DT 10_1101-2021_01_04_425177 22 44 toxic toxic JJ 10_1101-2021_01_04_425177 22 45 forms form NNS 10_1101-2021_01_04_425177 22 46 , , , 10_1101-2021_01_04_425177 22 47 for for IN 10_1101-2021_01_04_425177 22 48 example example NN 10_1101-2021_01_04_425177 22 49 by by IN 10_1101-2021_01_04_425177 22 50 promoting promote VBG 10_1101-2021_01_04_425177 22 51 rapid rapid JJ 10_1101-2021_01_04_425177 22 52 aggregation aggregation NN 10_1101-2021_01_04_425177 22 53 into into IN 10_1101-2021_01_04_425177 22 54 larger large JJR 10_1101-2021_01_04_425177 22 55 non non JJ 10_1101-2021_01_04_425177 22 56 - - JJ 10_1101-2021_01_04_425177 22 57 toxic toxic JJ 10_1101-2021_01_04_425177 22 58 aggregates aggregate NNS 10_1101-2021_01_04_425177 22 59 . . . 10_1101-2021_01_04_425177 23 1 We -PRON- PRP 10_1101-2021_01_04_425177 23 2 have have VBP 10_1101-2021_01_04_425177 23 3 previously previously RB 10_1101-2021_01_04_425177 23 4 demonstrated demonstrate VBN 10_1101-2021_01_04_425177 23 5 anti anti JJ 10_1101-2021_01_04_425177 23 6 - - JJ 10_1101-2021_01_04_425177 23 7 prion prion JJ 10_1101-2021_01_04_425177 23 8 properties property NNS 10_1101-2021_01_04_425177 23 9 in in IN 10_1101-2021_01_04_425177 23 10 short short JJ 10_1101-2021_01_04_425177 23 11 peptide peptide NN 10_1101-2021_01_04_425177 23 12 constructs construct NNS 10_1101-2021_01_04_425177 23 13 ( ( -LRB- 10_1101-2021_01_04_425177 23 14 up up IN 10_1101-2021_01_04_425177 23 15 to to TO 10_1101-2021_01_04_425177 23 16 30 30 CD 10_1101-2021_01_04_425177 23 17 residues residue NNS 10_1101-2021_01_04_425177 23 18 ) ) -RRB- 10_1101-2021_01_04_425177 23 19 with with IN 10_1101-2021_01_04_425177 23 20 sequences sequence NNS 10_1101-2021_01_04_425177 23 21 derived derive VBN 10_1101-2021_01_04_425177 23 22 from from IN 10_1101-2021_01_04_425177 23 23 the the DT 10_1101-2021_01_04_425177 23 24 unprocessed unprocessed JJ 10_1101-2021_01_04_425177 23 25 N N NNP 10_1101-2021_01_04_425177 23 26 - - HYPH 10_1101-2021_01_04_425177 23 27 termini termini NN 10_1101-2021_01_04_425177 23 28 of of IN 10_1101-2021_01_04_425177 23 29 mouse mouse NN 10_1101-2021_01_04_425177 23 30 and and CC 10_1101-2021_01_04_425177 23 31 .CC .CC : 10_1101-2021_01_04_425177 23 32 - - : 10_1101-2021_01_04_425177 23 33 BY by IN 10_1101-2021_01_04_425177 23 34 - - HYPH 10_1101-2021_01_04_425177 23 35 NC NC NNP 10_1101-2021_01_04_425177 23 36 - - HYPH 10_1101-2021_01_04_425177 23 37 ND ND NNP 10_1101-2021_01_04_425177 23 38 4.0 4.0 CD 10_1101-2021_01_04_425177 23 39 International international JJ 10_1101-2021_01_04_425177 23 40 licensemade licensemade NN 10_1101-2021_01_04_425177 23 41 available available JJ 10_1101-2021_01_04_425177 23 42 under under IN 10_1101-2021_01_04_425177 23 43 a a DT 10_1101-2021_01_04_425177 23 44 ( ( -LRB- 10_1101-2021_01_04_425177 23 45 which which WDT 10_1101-2021_01_04_425177 23 46 was be VBD 10_1101-2021_01_04_425177 23 47 not not RB 10_1101-2021_01_04_425177 23 48 certified certify VBN 10_1101-2021_01_04_425177 23 49 by by IN 10_1101-2021_01_04_425177 23 50 peer peer NN 10_1101-2021_01_04_425177 23 51 review review NN 10_1101-2021_01_04_425177 23 52 ) ) -RRB- 10_1101-2021_01_04_425177 23 53 is be VBZ 10_1101-2021_01_04_425177 23 54 the the DT 10_1101-2021_01_04_425177 23 55 author author NN 10_1101-2021_01_04_425177 23 56 / / SYM 10_1101-2021_01_04_425177 23 57 funder funder NN 10_1101-2021_01_04_425177 23 58 , , , 10_1101-2021_01_04_425177 23 59 who who WP 10_1101-2021_01_04_425177 23 60 has have VBZ 10_1101-2021_01_04_425177 23 61 granted grant VBN 10_1101-2021_01_04_425177 23 62 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 23 63 a a DT 10_1101-2021_01_04_425177 23 64 license license NN 10_1101-2021_01_04_425177 23 65 to to TO 10_1101-2021_01_04_425177 23 66 display display VB 10_1101-2021_01_04_425177 23 67 the the DT 10_1101-2021_01_04_425177 23 68 preprint preprint NN 10_1101-2021_01_04_425177 23 69 in in IN 10_1101-2021_01_04_425177 23 70 perpetuity perpetuity NN 10_1101-2021_01_04_425177 23 71 . . . 10_1101-2021_01_04_425177 24 1 It -PRON- PRP 10_1101-2021_01_04_425177 24 2 is be VBZ 10_1101-2021_01_04_425177 24 3 The the DT 10_1101-2021_01_04_425177 24 4 copyright copyright NN 10_1101-2021_01_04_425177 24 5 holder holder NN 10_1101-2021_01_04_425177 24 6 for for IN 10_1101-2021_01_04_425177 24 7 this this DT 10_1101-2021_01_04_425177 24 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 24 9 version version NN 10_1101-2021_01_04_425177 24 10 posted post VBD 10_1101-2021_01_04_425177 24 11 January January NNP 10_1101-2021_01_04_425177 24 12 4 4 CD 10_1101-2021_01_04_425177 24 13 , , , 10_1101-2021_01_04_425177 24 14 2021 2021 CD 10_1101-2021_01_04_425177 24 15 . . . 10_1101-2021_01_04_425177 24 16 ; ; : 10_1101-2021_01_04_425177 24 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 24 18 : : : 10_1101-2021_01_04_425177 24 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 24 20 preprint preprint NN 10_1101-2021_01_04_425177 24 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 VBZ 10_1101-2021_01_04_425177 24 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_04_425177 24 23 3 3 CD 10_1101-2021_01_04_425177 24 24 bovine bovine NN 10_1101-2021_01_04_425177 24 25 prion prion NN 10_1101-2021_01_04_425177 24 26 proteins protein NNS 10_1101-2021_01_04_425177 24 27 : : : 10_1101-2021_01_04_425177 24 28 such such JJ 10_1101-2021_01_04_425177 24 29 PrP prp NN 10_1101-2021_01_04_425177 24 30 - - HYPH 10_1101-2021_01_04_425177 24 31 derived derive VBN 10_1101-2021_01_04_425177 24 32 peptides peptide NNS 10_1101-2021_01_04_425177 24 33 induced induce VBD 10_1101-2021_01_04_425177 24 34 lower low JJR 10_1101-2021_01_04_425177 24 35 amounts amount NNS 10_1101-2021_01_04_425177 24 36 of of IN 10_1101-2021_01_04_425177 24 37 prion prion NN 10_1101-2021_01_04_425177 24 38 aggregates aggregate NNS 10_1101-2021_01_04_425177 24 39 resistant resistant JJ 10_1101-2021_01_04_425177 24 40 to to TO 10_1101-2021_01_04_425177 24 41 proteinase proteinase VB 10_1101-2021_01_04_425177 24 42 K K NNP 10_1101-2021_01_04_425177 24 43 in in IN 10_1101-2021_01_04_425177 24 44 prion prion NN 10_1101-2021_01_04_425177 24 45 - - HYPH 10_1101-2021_01_04_425177 24 46 infected infect VBN 10_1101-2021_01_04_425177 24 47 cells cell NNS 10_1101-2021_01_04_425177 24 48 ( ( -LRB- 10_1101-2021_01_04_425177 24 49 Löfgren Löfgren NNP 10_1101-2021_01_04_425177 24 50 et et NNP 10_1101-2021_01_04_425177 24 51 al al NNP 10_1101-2021_01_04_425177 24 52 . . NNP 10_1101-2021_01_04_425177 24 53 , , , 10_1101-2021_01_04_425177 24 54 2008 2008 CD 10_1101-2021_01_04_425177 24 55 ; ; : 10_1101-2021_01_04_425177 24 56 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 24 57 et et NNP 10_1101-2021_01_04_425177 24 58 al al NNP 10_1101-2021_01_04_425177 24 59 . . NNP 10_1101-2021_01_04_425177 24 60 , , , 10_1101-2021_01_04_425177 24 61 2014 2014 CD 10_1101-2021_01_04_425177 24 62 ) ) -RRB- 10_1101-2021_01_04_425177 24 63 . . . 10_1101-2021_01_04_425177 25 1 The the DT 10_1101-2021_01_04_425177 25 2 PrP prp NN 10_1101-2021_01_04_425177 25 3 - - HYPH 10_1101-2021_01_04_425177 25 4 derived derive VBN 10_1101-2021_01_04_425177 25 5 peptides peptide NNS 10_1101-2021_01_04_425177 25 6 consisted consist VBD 10_1101-2021_01_04_425177 25 7 of of IN 10_1101-2021_01_04_425177 25 8 an an DT 10_1101-2021_01_04_425177 25 9 N N NNP 10_1101-2021_01_04_425177 25 10 - - HYPH 10_1101-2021_01_04_425177 25 11 terminal terminal NN 10_1101-2021_01_04_425177 25 12 signal signal NN 10_1101-2021_01_04_425177 25 13 peptide peptide NN 10_1101-2021_01_04_425177 25 14 segment segment NN 10_1101-2021_01_04_425177 25 15 ( ( -LRB- 10_1101-2021_01_04_425177 25 16 different different JJ 10_1101-2021_01_04_425177 25 17 for for IN 10_1101-2021_01_04_425177 25 18 mouse mouse NN 10_1101-2021_01_04_425177 25 19 and and CC 10_1101-2021_01_04_425177 25 20 bovine bovine NNP 10_1101-2021_01_04_425177 25 21 PrP PrP NNP 10_1101-2021_01_04_425177 25 22 ) ) -RRB- 10_1101-2021_01_04_425177 25 23 , , , 10_1101-2021_01_04_425177 25 24 together together RB 10_1101-2021_01_04_425177 25 25 with with IN 10_1101-2021_01_04_425177 25 26 a a DT 10_1101-2021_01_04_425177 25 27 conserved conserve VBN 10_1101-2021_01_04_425177 25 28 positively positively RB 10_1101-2021_01_04_425177 25 29 charged charge VBN 10_1101-2021_01_04_425177 25 30 and and CC 10_1101-2021_01_04_425177 25 31 hydrophobic hydrophobic JJ 10_1101-2021_01_04_425177 25 32 hexapeptide hexapeptide NN 10_1101-2021_01_04_425177 25 33 ( ( -LRB- 10_1101-2021_01_04_425177 25 34 KKRPKP KKRPKP NNP 10_1101-2021_01_04_425177 25 35 ) ) -RRB- 10_1101-2021_01_04_425177 25 36 corresponding correspond VBG 10_1101-2021_01_04_425177 25 37 to to IN 10_1101-2021_01_04_425177 25 38 the the DT 10_1101-2021_01_04_425177 25 39 first first JJ 10_1101-2021_01_04_425177 25 40 six six CD 10_1101-2021_01_04_425177 25 41 residues residue NNS 10_1101-2021_01_04_425177 25 42 of of IN 10_1101-2021_01_04_425177 25 43 the the DT 10_1101-2021_01_04_425177 25 44 processed process VBN 10_1101-2021_01_04_425177 25 45 PrP PrP NNP 10_1101-2021_01_04_425177 25 46 protein protein NN 10_1101-2021_01_04_425177 25 47 . . . 10_1101-2021_01_04_425177 26 1 Our -PRON- PRP$ 10_1101-2021_01_04_425177 26 2 earlier early JJR 10_1101-2021_01_04_425177 26 3 studies study NNS 10_1101-2021_01_04_425177 26 4 had have VBD 10_1101-2021_01_04_425177 26 5 shown show VBN 10_1101-2021_01_04_425177 26 6 that that IN 10_1101-2021_01_04_425177 26 7 peptides peptide NNS 10_1101-2021_01_04_425177 26 8 with with IN 10_1101-2021_01_04_425177 26 9 such such JJ 10_1101-2021_01_04_425177 26 10 sequences sequence NNS 10_1101-2021_01_04_425177 26 11 were be VBD 10_1101-2021_01_04_425177 26 12 able able JJ 10_1101-2021_01_04_425177 26 13 to to TO 10_1101-2021_01_04_425177 26 14 interact interact VB 10_1101-2021_01_04_425177 26 15 with with IN 10_1101-2021_01_04_425177 26 16 and and CC 10_1101-2021_01_04_425177 26 17 penetrate penetrate VB 10_1101-2021_01_04_425177 26 18 cell cell NN 10_1101-2021_01_04_425177 26 19 membranes membrane NNS 10_1101-2021_01_04_425177 26 20 ( ( -LRB- 10_1101-2021_01_04_425177 26 21 Lundberg Lundberg NNP 10_1101-2021_01_04_425177 26 22 et et FW 10_1101-2021_01_04_425177 26 23 al al NNP 10_1101-2021_01_04_425177 26 24 . . NNP 10_1101-2021_01_04_425177 26 25 , , , 10_1101-2021_01_04_425177 26 26 2002 2002 CD 10_1101-2021_01_04_425177 26 27 ; ; : 10_1101-2021_01_04_425177 26 28 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 26 29 et et NNP 10_1101-2021_01_04_425177 26 30 al al NNP 10_1101-2021_01_04_425177 26 31 . . NNP 10_1101-2021_01_04_425177 26 32 , , , 10_1101-2021_01_04_425177 26 33 2005 2005 CD 10_1101-2021_01_04_425177 26 34 ; ; : 10_1101-2021_01_04_425177 26 35 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 26 36 et et NNP 10_1101-2021_01_04_425177 26 37 al al NNP 10_1101-2021_01_04_425177 26 38 . . NNP 10_1101-2021_01_04_425177 26 39 , , , 10_1101-2021_01_04_425177 26 40 2006 2006 CD 10_1101-2021_01_04_425177 26 41 ; ; : 10_1101-2021_01_04_425177 26 42 Oglecka Oglecka NNP 10_1101-2021_01_04_425177 26 43 et et NNP 10_1101-2021_01_04_425177 26 44 al al NNP 10_1101-2021_01_04_425177 26 45 . . NNP 10_1101-2021_01_04_425177 26 46 , , , 10_1101-2021_01_04_425177 26 47 2008 2008 CD 10_1101-2021_01_04_425177 26 48 ) ) -RRB- 10_1101-2021_01_04_425177 26 49 . . . 10_1101-2021_01_04_425177 27 1 The the DT 10_1101-2021_01_04_425177 27 2 anti- anti- NN 10_1101-2021_01_04_425177 27 3 prion prion NN 10_1101-2021_01_04_425177 27 4 effects effect NNS 10_1101-2021_01_04_425177 27 5 of of IN 10_1101-2021_01_04_425177 27 6 the the DT 10_1101-2021_01_04_425177 27 7 PrP prp NN 10_1101-2021_01_04_425177 27 8 - - HYPH 10_1101-2021_01_04_425177 27 9 derived derive VBN 10_1101-2021_01_04_425177 27 10 peptides peptide NNS 10_1101-2021_01_04_425177 27 11 were be VBD 10_1101-2021_01_04_425177 27 12 lost lose VBN 10_1101-2021_01_04_425177 27 13 when when WRB 10_1101-2021_01_04_425177 27 14 the the DT 10_1101-2021_01_04_425177 27 15 KKRPKP KKRPKP NNP 10_1101-2021_01_04_425177 27 16 hexapeptide hexapeptide NN 10_1101-2021_01_04_425177 27 17 was be VBD 10_1101-2021_01_04_425177 27 18 coupled couple VBN 10_1101-2021_01_04_425177 27 19 to to IN 10_1101-2021_01_04_425177 27 20 various various JJ 10_1101-2021_01_04_425177 27 21 peptides peptide NNS 10_1101-2021_01_04_425177 27 22 with with IN 10_1101-2021_01_04_425177 27 23 cell cell NN 10_1101-2021_01_04_425177 27 24 - - HYPH 10_1101-2021_01_04_425177 27 25 penetrating penetrating NN 10_1101-2021_01_04_425177 27 26 properties property NNS 10_1101-2021_01_04_425177 27 27 ( ( -LRB- 10_1101-2021_01_04_425177 27 28 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 27 29 et et NNP 10_1101-2021_01_04_425177 27 30 al al NNP 10_1101-2021_01_04_425177 27 31 . . NNP 10_1101-2021_01_04_425177 27 32 , , , 10_1101-2021_01_04_425177 27 33 2014 2014 CD 10_1101-2021_01_04_425177 27 34 ) ) -RRB- 10_1101-2021_01_04_425177 27 35 . . . 10_1101-2021_01_04_425177 28 1 The the DT 10_1101-2021_01_04_425177 28 2 anti anti JJ 10_1101-2021_01_04_425177 28 3 - - JJ 10_1101-2021_01_04_425177 28 4 prion prion JJ 10_1101-2021_01_04_425177 28 5 effects effect NNS 10_1101-2021_01_04_425177 28 6 were be VBD 10_1101-2021_01_04_425177 28 7 however however RB 10_1101-2021_01_04_425177 28 8 retained retain VBN 10_1101-2021_01_04_425177 28 9 when when WRB 10_1101-2021_01_04_425177 28 10 KKRPKP KKRPKP NNP 10_1101-2021_01_04_425177 28 11 was be VBD 10_1101-2021_01_04_425177 28 12 coupled couple VBN 10_1101-2021_01_04_425177 28 13 to to IN 10_1101-2021_01_04_425177 28 14 the the DT 10_1101-2021_01_04_425177 28 15 signal signal JJ 10_1101-2021_01_04_425177 28 16 sequence sequence NN 10_1101-2021_01_04_425177 28 17 of of IN 10_1101-2021_01_04_425177 28 18 the the DT 10_1101-2021_01_04_425177 28 19 Neural neural JJ 10_1101-2021_01_04_425177 28 20 cell cell NN 10_1101-2021_01_04_425177 28 21 adhesion adhesion NN 10_1101-2021_01_04_425177 28 22 molecule-1 molecule-1 NNP 10_1101-2021_01_04_425177 28 23 ( ( -LRB- 10_1101-2021_01_04_425177 28 24 i.e. i.e. FW 10_1101-2021_01_04_425177 28 25 , , , 10_1101-2021_01_04_425177 28 26 NCAM11 NCAM11 NNP 10_1101-2021_01_04_425177 28 27 - - HYPH 10_1101-2021_01_04_425177 28 28 19 19 CD 10_1101-2021_01_04_425177 28 29 ) ) -RRB- 10_1101-2021_01_04_425177 28 30 ( ( -LRB- 10_1101-2021_01_04_425177 28 31 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 28 32 et et NNP 10_1101-2021_01_04_425177 28 33 al al NNP 10_1101-2021_01_04_425177 28 34 . . NNP 10_1101-2021_01_04_425177 28 35 , , , 10_1101-2021_01_04_425177 28 36 2014 2014 CD 10_1101-2021_01_04_425177 28 37 ) ) -RRB- 10_1101-2021_01_04_425177 28 38 . . . 10_1101-2021_01_04_425177 29 1 The the DT 10_1101-2021_01_04_425177 29 2 mouse mouse NN 10_1101-2021_01_04_425177 29 3 PrP1 prp1 NN 10_1101-2021_01_04_425177 29 4 - - HYPH 10_1101-2021_01_04_425177 29 5 28 28 CD 10_1101-2021_01_04_425177 29 6 segment segment NN 10_1101-2021_01_04_425177 29 7 and and CC 10_1101-2021_01_04_425177 29 8 the the DT 10_1101-2021_01_04_425177 29 9 NCAM11 NCAM11 NNP 10_1101-2021_01_04_425177 29 10 - - HYPH 10_1101-2021_01_04_425177 29 11 19-KKRPKP 19-KKRPKP NNP 10_1101-2021_01_04_425177 29 12 construct construct NN 10_1101-2021_01_04_425177 29 13 are be VBP 10_1101-2021_01_04_425177 29 14 both both DT 10_1101-2021_01_04_425177 29 15 amyloidogenic amyloidogenic JJ 10_1101-2021_01_04_425177 29 16 in in IN 10_1101-2021_01_04_425177 29 17 themselves -PRON- PRP 10_1101-2021_01_04_425177 29 18 , , , 10_1101-2021_01_04_425177 29 19 as as IN 10_1101-2021_01_04_425177 29 20 they -PRON- PRP 10_1101-2021_01_04_425177 29 21 form form VBP 10_1101-2021_01_04_425177 29 22 amyloid amyloid NN 10_1101-2021_01_04_425177 29 23 fibrils fibril NNS 10_1101-2021_01_04_425177 29 24 by by IN 10_1101-2021_01_04_425177 29 25 self self NN 10_1101-2021_01_04_425177 29 26 - - HYPH 10_1101-2021_01_04_425177 29 27 aggregation aggregation NN 10_1101-2021_01_04_425177 29 28 ( ( -LRB- 10_1101-2021_01_04_425177 29 29 Mukundan Mukundan NNP 10_1101-2021_01_04_425177 29 30 et et FW 10_1101-2021_01_04_425177 29 31 al al NNP 10_1101-2021_01_04_425177 29 32 . . NNP 10_1101-2021_01_04_425177 29 33 , , , 10_1101-2021_01_04_425177 29 34 2017 2017 CD 10_1101-2021_01_04_425177 29 35 ; ; : 10_1101-2021_01_04_425177 29 36 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 29 37 et et FW 10_1101-2021_01_04_425177 29 38 al al NNP 10_1101-2021_01_04_425177 29 39 . . NNP 10_1101-2021_01_04_425177 29 40 , , , 10_1101-2021_01_04_425177 29 41 2019 2019 CD 10_1101-2021_01_04_425177 29 42 ) ) -RRB- 10_1101-2021_01_04_425177 29 43 . . . 10_1101-2021_01_04_425177 30 1 The the DT 10_1101-2021_01_04_425177 30 2 NCAM11 NCAM11 NNP 10_1101-2021_01_04_425177 30 3 - - HYPH 10_1101-2021_01_04_425177 30 4 19-KKRPKP 19-KKRPKP NNP 10_1101-2021_01_04_425177 30 5 construct construct NN 10_1101-2021_01_04_425177 30 6 was be VBD 10_1101-2021_01_04_425177 30 7 recently recently RB 10_1101-2021_01_04_425177 30 8 shown show VBN 10_1101-2021_01_04_425177 30 9 to to TO 10_1101-2021_01_04_425177 30 10 inhibit inhibit VB 10_1101-2021_01_04_425177 30 11 aggregation aggregation NN 10_1101-2021_01_04_425177 30 12 of of IN 10_1101-2021_01_04_425177 30 13 the the DT 10_1101-2021_01_04_425177 30 14 amyloid amyloid NN 10_1101-2021_01_04_425177 30 15 - - HYPH 10_1101-2021_01_04_425177 30 16 β β NN 10_1101-2021_01_04_425177 30 17 peptide peptide NN 10_1101-2021_01_04_425177 30 18 involved involve VBN 10_1101-2021_01_04_425177 30 19 in in IN 10_1101-2021_01_04_425177 30 20 Alzheimer Alzheimer NNP 10_1101-2021_01_04_425177 30 21 ’s ’s POS 10_1101-2021_01_04_425177 30 22 disease disease NN 10_1101-2021_01_04_425177 30 23 ( ( -LRB- 10_1101-2021_01_04_425177 30 24 Henning Henning NNP 10_1101-2021_01_04_425177 30 25 - - HYPH 10_1101-2021_01_04_425177 30 26 Knechtel Knechtel NNP 10_1101-2021_01_04_425177 30 27 et et FW 10_1101-2021_01_04_425177 30 28 al al NNP 10_1101-2021_01_04_425177 30 29 . . NNP 10_1101-2021_01_04_425177 30 30 , , , 10_1101-2021_01_04_425177 30 31 2020 2020 CD 10_1101-2021_01_04_425177 30 32 ) ) -RRB- 10_1101-2021_01_04_425177 30 33 , , , 10_1101-2021_01_04_425177 30 34 and and CC 10_1101-2021_01_04_425177 30 35 to to TO 10_1101-2021_01_04_425177 30 36 promote promote VB 10_1101-2021_01_04_425177 30 37 in in IN 10_1101-2021_01_04_425177 30 38 vitro vitro FW 10_1101-2021_01_04_425177 30 39 aggregation aggregation NN 10_1101-2021_01_04_425177 30 40 of of IN 10_1101-2021_01_04_425177 30 41 the the DT 10_1101-2021_01_04_425177 30 42 amyloid amyloid NN 10_1101-2021_01_04_425177 30 43 protein protein NN 10_1101-2021_01_04_425177 30 44 S100A9 S100A9 NNP 10_1101-2021_01_04_425177 30 45 ( ( -LRB- 10_1101-2021_01_04_425177 30 46 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 30 47 et et FW 10_1101-2021_01_04_425177 30 48 al al NNP 10_1101-2021_01_04_425177 30 49 . . NNP 10_1101-2021_01_04_425177 30 50 , , , 10_1101-2021_01_04_425177 30 51 2019 2019 CD 10_1101-2021_01_04_425177 30 52 ) ) -RRB- 10_1101-2021_01_04_425177 30 53 , , , 10_1101-2021_01_04_425177 30 54 which which WDT 10_1101-2021_01_04_425177 30 55 is be VBZ 10_1101-2021_01_04_425177 30 56 involved involve VBN 10_1101-2021_01_04_425177 30 57 in in IN 10_1101-2021_01_04_425177 30 58 amyloid amyloid NN 10_1101-2021_01_04_425177 30 59 - - HYPH 10_1101-2021_01_04_425177 30 60 related relate VBN 10_1101-2021_01_04_425177 30 61 and and CC 10_1101-2021_01_04_425177 30 62 other other JJ 10_1101-2021_01_04_425177 30 63 inflammatory inflammatory JJ 10_1101-2021_01_04_425177 30 64 processes process NNS 10_1101-2021_01_04_425177 30 65 ( ( -LRB- 10_1101-2021_01_04_425177 30 66 Horvath Horvath NNP 10_1101-2021_01_04_425177 30 67 et et NNP 10_1101-2021_01_04_425177 30 68 al al NNP 10_1101-2021_01_04_425177 30 69 . . NNP 10_1101-2021_01_04_425177 30 70 , , , 10_1101-2021_01_04_425177 30 71 2018 2018 CD 10_1101-2021_01_04_425177 30 72 ; ; : 10_1101-2021_01_04_425177 30 73 Wang Wang NNP 10_1101-2021_01_04_425177 30 74 et et NNP 10_1101-2021_01_04_425177 30 75 al al NNP 10_1101-2021_01_04_425177 30 76 . . NNP 10_1101-2021_01_04_425177 30 77 , , , 10_1101-2021_01_04_425177 30 78 2019 2019 CD 10_1101-2021_01_04_425177 30 79 ; ; : 10_1101-2021_01_04_425177 30 80 Wang Wang NNP 10_1101-2021_01_04_425177 30 81 et et NNP 10_1101-2021_01_04_425177 30 82 al al NNP 10_1101-2021_01_04_425177 30 83 . . NNP 10_1101-2021_01_04_425177 30 84 , , , 10_1101-2021_01_04_425177 30 85 2014 2014 CD 10_1101-2021_01_04_425177 30 86 ) ) -RRB- 10_1101-2021_01_04_425177 30 87 . . . 10_1101-2021_01_04_425177 31 1 Almost almost RB 10_1101-2021_01_04_425177 31 2 identical identical JJ 10_1101-2021_01_04_425177 31 3 results result NNS 10_1101-2021_01_04_425177 31 4 were be VBD 10_1101-2021_01_04_425177 31 5 obtained obtain VBN 10_1101-2021_01_04_425177 31 6 for for IN 10_1101-2021_01_04_425177 31 7 a a DT 10_1101-2021_01_04_425177 31 8 similar similar JJ 10_1101-2021_01_04_425177 31 9 amyloidogenic amyloidogenic JJ 10_1101-2021_01_04_425177 31 10 25 25 CD 10_1101-2021_01_04_425177 31 11 residue residue NN 10_1101-2021_01_04_425177 31 12 - - HYPH 10_1101-2021_01_04_425177 31 13 construct construct NN 10_1101-2021_01_04_425177 31 14 , , , 10_1101-2021_01_04_425177 31 15 i.e. i.e. FW 10_1101-2021_01_04_425177 32 1 NCAM11 NCAM11 NNP 10_1101-2021_01_04_425177 32 2 - - HYPH 10_1101-2021_01_04_425177 32 3 19-KKLVFF 19-KKLVFF NNP 10_1101-2021_01_04_425177 32 4 ( ( -LRB- 10_1101-2021_01_04_425177 32 5 from from IN 10_1101-2021_01_04_425177 32 6 here here RB 10_1101-2021_01_04_425177 32 7 onwards onwards RB 10_1101-2021_01_04_425177 32 8 : : : 10_1101-2021_01_04_425177 32 9 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 32 10 ) ) -RRB- 10_1101-2021_01_04_425177 32 11 ( ( -LRB- 10_1101-2021_01_04_425177 32 12 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 32 13 et et FW 10_1101-2021_01_04_425177 32 14 al al NNP 10_1101-2021_01_04_425177 32 15 . . NNP 10_1101-2021_01_04_425177 32 16 , , , 10_1101-2021_01_04_425177 32 17 2019 2019 CD 10_1101-2021_01_04_425177 32 18 ) ) -RRB- 10_1101-2021_01_04_425177 32 19 . . . 10_1101-2021_01_04_425177 33 1 The the DT 10_1101-2021_01_04_425177 33 2 KLVFF KLVFF NNP 10_1101-2021_01_04_425177 33 3 sequence sequence NN 10_1101-2021_01_04_425177 33 4 originates originate VBZ 10_1101-2021_01_04_425177 33 5 from from IN 10_1101-2021_01_04_425177 33 6 the the DT 10_1101-2021_01_04_425177 33 7 hydrophobic hydrophobic JJ 10_1101-2021_01_04_425177 33 8 core core NN 10_1101-2021_01_04_425177 33 9 ( ( -LRB- 10_1101-2021_01_04_425177 33 10 residues residues NNP 10_1101-2021_01_04_425177 33 11 16 16 CD 10_1101-2021_01_04_425177 33 12 - - SYM 10_1101-2021_01_04_425177 33 13 20 20 CD 10_1101-2021_01_04_425177 33 14 ) ) -RRB- 10_1101-2021_01_04_425177 33 15 of of IN 10_1101-2021_01_04_425177 33 16 the the DT 10_1101-2021_01_04_425177 33 17 Aβ Aβ NNP 10_1101-2021_01_04_425177 33 18 peptide peptide NN 10_1101-2021_01_04_425177 33 19 : : : 10_1101-2021_01_04_425177 33 20 this this DT 10_1101-2021_01_04_425177 33 21 pentapeptide pentapeptide NN 10_1101-2021_01_04_425177 33 22 is be VBZ 10_1101-2021_01_04_425177 33 23 known know VBN 10_1101-2021_01_04_425177 33 24 to to TO 10_1101-2021_01_04_425177 33 25 inhibit inhibit VB 10_1101-2021_01_04_425177 33 26 aggregation aggregation NN 10_1101-2021_01_04_425177 33 27 of of IN 10_1101-2021_01_04_425177 33 28 the the DT 10_1101-2021_01_04_425177 33 29 full full JJ 10_1101-2021_01_04_425177 33 30 - - HYPH 10_1101-2021_01_04_425177 33 31 length length NN 10_1101-2021_01_04_425177 33 32 Aβ Aβ NNP 10_1101-2021_01_04_425177 33 33 peptide peptide NN 10_1101-2021_01_04_425177 33 34 ( ( -LRB- 10_1101-2021_01_04_425177 33 35 Tjernberg Tjernberg NNP 10_1101-2021_01_04_425177 33 36 et et NNP 10_1101-2021_01_04_425177 33 37 al al NNP 10_1101-2021_01_04_425177 33 38 . . NNP 10_1101-2021_01_04_425177 33 39 , , , 10_1101-2021_01_04_425177 33 40 1996 1996 CD 10_1101-2021_01_04_425177 33 41 ) ) -RRB- 10_1101-2021_01_04_425177 33 42 . . . 10_1101-2021_01_04_425177 34 1 In in IN 10_1101-2021_01_04_425177 34 2 the the DT 10_1101-2021_01_04_425177 34 3 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 34 4 construct construct NN 10_1101-2021_01_04_425177 34 5 , , , 10_1101-2021_01_04_425177 34 6 an an DT 10_1101-2021_01_04_425177 34 7 additional additional JJ 10_1101-2021_01_04_425177 34 8 lysine lysine NN 10_1101-2021_01_04_425177 34 9 residue residue NN 10_1101-2021_01_04_425177 34 10 was be VBD 10_1101-2021_01_04_425177 34 11 added add VBN 10_1101-2021_01_04_425177 34 12 to to IN 10_1101-2021_01_04_425177 34 13 the the DT 10_1101-2021_01_04_425177 34 14 KLVFF KLVFF NNP 10_1101-2021_01_04_425177 34 15 sequence sequence NN 10_1101-2021_01_04_425177 34 16 for for IN 10_1101-2021_01_04_425177 34 17 increased increase VBN 10_1101-2021_01_04_425177 34 18 solubility solubility NN 10_1101-2021_01_04_425177 34 19 ( ( -LRB- 10_1101-2021_01_04_425177 34 20 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 34 21 et et FW 10_1101-2021_01_04_425177 34 22 al al NNP 10_1101-2021_01_04_425177 34 23 . . NNP 10_1101-2021_01_04_425177 34 24 , , , 10_1101-2021_01_04_425177 34 25 2019 2019 CD 10_1101-2021_01_04_425177 34 26 ) ) -RRB- 10_1101-2021_01_04_425177 34 27 . . . 10_1101-2021_01_04_425177 35 1 The the DT 10_1101-2021_01_04_425177 35 2 molecular molecular JJ 10_1101-2021_01_04_425177 35 3 properties property NNS 10_1101-2021_01_04_425177 35 4 of of IN 10_1101-2021_01_04_425177 35 5 the the DT 10_1101-2021_01_04_425177 35 6 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 35 7 sequence sequence NN 10_1101-2021_01_04_425177 35 8 and and CC 10_1101-2021_01_04_425177 35 9 its -PRON- PRP$ 10_1101-2021_01_04_425177 35 10 segments segment NNS 10_1101-2021_01_04_425177 35 11 are be VBP 10_1101-2021_01_04_425177 35 12 shown show VBN 10_1101-2021_01_04_425177 35 13 in in IN 10_1101-2021_01_04_425177 35 14 Table table NN 10_1101-2021_01_04_425177 35 15 1 1 CD 10_1101-2021_01_04_425177 35 16 , , , 10_1101-2021_01_04_425177 35 17 including include VBG 10_1101-2021_01_04_425177 35 18 .CC .CC : 10_1101-2021_01_04_425177 35 19 - - HYPH 10_1101-2021_01_04_425177 35 20 BY by IN 10_1101-2021_01_04_425177 35 21 - - HYPH 10_1101-2021_01_04_425177 35 22 NC NC NNP 10_1101-2021_01_04_425177 35 23 - - HYPH 10_1101-2021_01_04_425177 35 24 ND ND NNP 10_1101-2021_01_04_425177 35 25 4.0 4.0 CD 10_1101-2021_01_04_425177 35 26 International international JJ 10_1101-2021_01_04_425177 35 27 licensemade licensemade NN 10_1101-2021_01_04_425177 35 28 available available JJ 10_1101-2021_01_04_425177 35 29 under under IN 10_1101-2021_01_04_425177 35 30 a a DT 10_1101-2021_01_04_425177 35 31 ( ( -LRB- 10_1101-2021_01_04_425177 35 32 which which WDT 10_1101-2021_01_04_425177 35 33 was be VBD 10_1101-2021_01_04_425177 35 34 not not RB 10_1101-2021_01_04_425177 35 35 certified certify VBN 10_1101-2021_01_04_425177 35 36 by by IN 10_1101-2021_01_04_425177 35 37 peer peer NN 10_1101-2021_01_04_425177 35 38 review review NN 10_1101-2021_01_04_425177 35 39 ) ) -RRB- 10_1101-2021_01_04_425177 35 40 is be VBZ 10_1101-2021_01_04_425177 35 41 the the DT 10_1101-2021_01_04_425177 35 42 author author NN 10_1101-2021_01_04_425177 35 43 / / SYM 10_1101-2021_01_04_425177 35 44 funder funder NN 10_1101-2021_01_04_425177 35 45 , , , 10_1101-2021_01_04_425177 35 46 who who WP 10_1101-2021_01_04_425177 35 47 has have VBZ 10_1101-2021_01_04_425177 35 48 granted grant VBN 10_1101-2021_01_04_425177 35 49 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 35 50 a a DT 10_1101-2021_01_04_425177 35 51 license license NN 10_1101-2021_01_04_425177 35 52 to to TO 10_1101-2021_01_04_425177 35 53 display display VB 10_1101-2021_01_04_425177 35 54 the the DT 10_1101-2021_01_04_425177 35 55 preprint preprint NN 10_1101-2021_01_04_425177 35 56 in in IN 10_1101-2021_01_04_425177 35 57 perpetuity perpetuity NN 10_1101-2021_01_04_425177 35 58 . . . 10_1101-2021_01_04_425177 36 1 It -PRON- PRP 10_1101-2021_01_04_425177 36 2 is be VBZ 10_1101-2021_01_04_425177 36 3 The the DT 10_1101-2021_01_04_425177 36 4 copyright copyright NN 10_1101-2021_01_04_425177 36 5 holder holder NN 10_1101-2021_01_04_425177 36 6 for for IN 10_1101-2021_01_04_425177 36 7 this this DT 10_1101-2021_01_04_425177 36 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 36 9 version version NN 10_1101-2021_01_04_425177 36 10 posted post VBD 10_1101-2021_01_04_425177 36 11 January January NNP 10_1101-2021_01_04_425177 36 12 4 4 CD 10_1101-2021_01_04_425177 36 13 , , , 10_1101-2021_01_04_425177 36 14 2021 2021 CD 10_1101-2021_01_04_425177 36 15 . . . 10_1101-2021_01_04_425177 36 16 ; ; : 10_1101-2021_01_04_425177 36 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 36 18 : : : 10_1101-2021_01_04_425177 36 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 36 20 preprint preprint NN 10_1101-2021_01_04_425177 36 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 VBZ 10_1101-2021_01_04_425177 36 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_04_425177 36 23 4 4 CD 10_1101-2021_01_04_425177 36 24 hydrophobicity hydrophobicity NN 10_1101-2021_01_04_425177 36 25 values value NNS 10_1101-2021_01_04_425177 36 26 calculated calculate VBN 10_1101-2021_01_04_425177 36 27 according accord VBG 10_1101-2021_01_04_425177 36 28 to to IN 10_1101-2021_01_04_425177 36 29 the the DT 10_1101-2021_01_04_425177 36 30 Wimley Wimley NNP 10_1101-2021_01_04_425177 36 31 - - HYPH 10_1101-2021_01_04_425177 36 32 White White NNP 10_1101-2021_01_04_425177 36 33 whole whole JJ 10_1101-2021_01_04_425177 36 34 residue residue JJ 10_1101-2021_01_04_425177 36 35 hydrophobicity hydrophobicity NN 10_1101-2021_01_04_425177 36 36 scale scale NN 10_1101-2021_01_04_425177 36 37 ( ( -LRB- 10_1101-2021_01_04_425177 36 38 Wang Wang NNP 10_1101-2021_01_04_425177 36 39 et et NNP 10_1101-2021_01_04_425177 36 40 al al NNP 10_1101-2021_01_04_425177 36 41 . . NNP 10_1101-2021_01_04_425177 36 42 , , , 10_1101-2021_01_04_425177 36 43 2016 2016 CD 10_1101-2021_01_04_425177 36 44 ; ; : 10_1101-2021_01_04_425177 36 45 Wimley Wimley NNP 10_1101-2021_01_04_425177 36 46 and and CC 10_1101-2021_01_04_425177 36 47 White White NNP 10_1101-2021_01_04_425177 36 48 , , , 10_1101-2021_01_04_425177 36 49 1996 1996 CD 10_1101-2021_01_04_425177 36 50 ) ) -RRB- 10_1101-2021_01_04_425177 36 51 . . . 10_1101-2021_01_04_425177 37 1 As as IN 10_1101-2021_01_04_425177 37 2 the the DT 10_1101-2021_01_04_425177 37 3 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 37 4 construct construct VBP 10_1101-2021_01_04_425177 37 5 inhibits inhibit NNS 10_1101-2021_01_04_425177 37 6 fibrillation fibrillation NN 10_1101-2021_01_04_425177 37 7 of of IN 10_1101-2021_01_04_425177 37 8 the the DT 10_1101-2021_01_04_425177 37 9 Aβ Aβ NNP 10_1101-2021_01_04_425177 37 10 peptide peptide NN 10_1101-2021_01_04_425177 37 11 ( ( -LRB- 10_1101-2021_01_04_425177 37 12 Henning- Henning- NNP 10_1101-2021_01_04_425177 37 13 Knechtel Knechtel NNP 10_1101-2021_01_04_425177 37 14 et et FW 10_1101-2021_01_04_425177 37 15 al al NNP 10_1101-2021_01_04_425177 37 16 . . NNP 10_1101-2021_01_04_425177 37 17 , , , 10_1101-2021_01_04_425177 37 18 2020 2020 CD 10_1101-2021_01_04_425177 37 19 ) ) -RRB- 10_1101-2021_01_04_425177 37 20 , , , 10_1101-2021_01_04_425177 37 21 but but CC 10_1101-2021_01_04_425177 37 22 promotes promote VBZ 10_1101-2021_01_04_425177 37 23 ( ( -LRB- 10_1101-2021_01_04_425177 37 24 co-)aggregation co-)aggregation NN 10_1101-2021_01_04_425177 37 25 of of IN 10_1101-2021_01_04_425177 37 26 the the DT 10_1101-2021_01_04_425177 37 27 S100A9 s100a9 JJ 10_1101-2021_01_04_425177 37 28 protein protein NN 10_1101-2021_01_04_425177 37 29 ( ( -LRB- 10_1101-2021_01_04_425177 37 30 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 37 31 et et FW 10_1101-2021_01_04_425177 37 32 al al NNP 10_1101-2021_01_04_425177 37 33 . . NNP 10_1101-2021_01_04_425177 37 34 , , , 10_1101-2021_01_04_425177 37 35 2019 2019 CD 10_1101-2021_01_04_425177 37 36 ) ) -RRB- 10_1101-2021_01_04_425177 37 37 , , , 10_1101-2021_01_04_425177 37 38 it -PRON- PRP 10_1101-2021_01_04_425177 37 39 is be VBZ 10_1101-2021_01_04_425177 37 40 unclear unclear JJ 10_1101-2021_01_04_425177 37 41 how how WRB 10_1101-2021_01_04_425177 37 42 the the DT 10_1101-2021_01_04_425177 37 43 construct construct NN 10_1101-2021_01_04_425177 37 44 may may MD 10_1101-2021_01_04_425177 37 45 affect affect VB 10_1101-2021_01_04_425177 37 46 the the DT 10_1101-2021_01_04_425177 37 47 aggregation aggregation NN 10_1101-2021_01_04_425177 37 48 of of IN 10_1101-2021_01_04_425177 37 49 the the DT 10_1101-2021_01_04_425177 37 50 PrP PrP NNP 10_1101-2021_01_04_425177 37 51 protein protein NN 10_1101-2021_01_04_425177 37 52 ( ( -LRB- 10_1101-2021_01_04_425177 37 53 if if IN 10_1101-2021_01_04_425177 37 54 at at RB 10_1101-2021_01_04_425177 37 55 all all RB 10_1101-2021_01_04_425177 37 56 ) ) -RRB- 10_1101-2021_01_04_425177 37 57 . . . 10_1101-2021_01_04_425177 38 1 Here here RB 10_1101-2021_01_04_425177 38 2 , , , 10_1101-2021_01_04_425177 38 3 we -PRON- PRP 10_1101-2021_01_04_425177 38 4 use use VBP 10_1101-2021_01_04_425177 38 5 Atomic Atomic NNP 10_1101-2021_01_04_425177 38 6 Force Force NNP 10_1101-2021_01_04_425177 38 7 Microscopy Microscopy NNP 10_1101-2021_01_04_425177 38 8 ( ( -LRB- 10_1101-2021_01_04_425177 38 9 AFM AFM NNP 10_1101-2021_01_04_425177 38 10 ) ) -RRB- 10_1101-2021_01_04_425177 38 11 imaging image VBG 10_1101-2021_01_04_425177 38 12 to to TO 10_1101-2021_01_04_425177 38 13 investigate investigate VB 10_1101-2021_01_04_425177 38 14 if if IN 10_1101-2021_01_04_425177 38 15 there there EX 10_1101-2021_01_04_425177 38 16 is be VBZ 10_1101-2021_01_04_425177 38 17 a a DT 10_1101-2021_01_04_425177 38 18 direct direct JJ 10_1101-2021_01_04_425177 38 19 effect effect NN 10_1101-2021_01_04_425177 38 20 of of IN 10_1101-2021_01_04_425177 38 21 the the DT 10_1101-2021_01_04_425177 38 22 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 38 23 construct construct VB 10_1101-2021_01_04_425177 38 24 on on IN 10_1101-2021_01_04_425177 38 25 the the DT 10_1101-2021_01_04_425177 38 26 in in FW 10_1101-2021_01_04_425177 38 27 vitro vitro FW 10_1101-2021_01_04_425177 38 28 aggregation aggregation NN 10_1101-2021_01_04_425177 38 29 of of IN 10_1101-2021_01_04_425177 38 30 the the DT 10_1101-2021_01_04_425177 38 31 human human JJ 10_1101-2021_01_04_425177 38 32 PrP PrP NNP 10_1101-2021_01_04_425177 38 33 protein protein NN 10_1101-2021_01_04_425177 38 34 . . . 10_1101-2021_01_04_425177 39 1 Answering answer VBG 10_1101-2021_01_04_425177 39 2 this this DT 10_1101-2021_01_04_425177 39 3 question question NN 10_1101-2021_01_04_425177 39 4 might may MD 10_1101-2021_01_04_425177 39 5 help help VB 10_1101-2021_01_04_425177 39 6 clarify clarify VB 10_1101-2021_01_04_425177 39 7 the the DT 10_1101-2021_01_04_425177 39 8 mechanisms mechanism NNS 10_1101-2021_01_04_425177 39 9 underlying underlie VBG 10_1101-2021_01_04_425177 39 10 the the DT 10_1101-2021_01_04_425177 39 11 previously previously RB 10_1101-2021_01_04_425177 39 12 observed observe VBN 10_1101-2021_01_04_425177 39 13 beneficial beneficial JJ 10_1101-2021_01_04_425177 39 14 effects effect NNS 10_1101-2021_01_04_425177 39 15 of of IN 10_1101-2021_01_04_425177 39 16 such such JJ 10_1101-2021_01_04_425177 39 17 peptide peptide JJ 10_1101-2021_01_04_425177 39 18 constructs construct NNS 10_1101-2021_01_04_425177 39 19 on on IN 10_1101-2021_01_04_425177 39 20 PrP PrP NNP 10_1101-2021_01_04_425177 39 21 infectivity infectivity NN 10_1101-2021_01_04_425177 39 22 ( ( -LRB- 10_1101-2021_01_04_425177 39 23 Löfgren Löfgren NNP 10_1101-2021_01_04_425177 39 24 et et NNP 10_1101-2021_01_04_425177 39 25 al al NNP 10_1101-2021_01_04_425177 39 26 . . NNP 10_1101-2021_01_04_425177 39 27 , , , 10_1101-2021_01_04_425177 39 28 2008 2008 CD 10_1101-2021_01_04_425177 39 29 ; ; : 10_1101-2021_01_04_425177 39 30 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 39 31 et et NNP 10_1101-2021_01_04_425177 39 32 al al NNP 10_1101-2021_01_04_425177 39 33 . . NNP 10_1101-2021_01_04_425177 39 34 , , , 10_1101-2021_01_04_425177 39 35 2014 2014 CD 10_1101-2021_01_04_425177 39 36 ) ) -RRB- 10_1101-2021_01_04_425177 39 37 . . . 10_1101-2021_01_04_425177 40 1 Table table NN 10_1101-2021_01_04_425177 40 2 1 1 CD 10_1101-2021_01_04_425177 40 3 . . . 10_1101-2021_01_04_425177 41 1 Primary primary JJ 10_1101-2021_01_04_425177 41 2 sequences sequence NNS 10_1101-2021_01_04_425177 41 3 and and CC 10_1101-2021_01_04_425177 41 4 molecular molecular JJ 10_1101-2021_01_04_425177 41 5 properties property NNS 10_1101-2021_01_04_425177 41 6 of of IN 10_1101-2021_01_04_425177 41 7 the the DT 10_1101-2021_01_04_425177 41 8 human human JJ 10_1101-2021_01_04_425177 41 9 PrP PrP NNP 10_1101-2021_01_04_425177 41 10 protein protein NN 10_1101-2021_01_04_425177 41 11 , , , 10_1101-2021_01_04_425177 41 12 the the DT 10_1101-2021_01_04_425177 41 13 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 41 14 peptide peptide NN 10_1101-2021_01_04_425177 41 15 construct construct NN 10_1101-2021_01_04_425177 41 16 , , , 10_1101-2021_01_04_425177 41 17 and and CC 10_1101-2021_01_04_425177 41 18 its -PRON- PRP$ 10_1101-2021_01_04_425177 41 19 parts part NNS 10_1101-2021_01_04_425177 41 20 . . . 10_1101-2021_01_04_425177 42 1 Protein Protein NNP 10_1101-2021_01_04_425177 42 2 Sequence Sequence NNP 10_1101-2021_01_04_425177 42 3 Isoelectric Isoelectric NNP 10_1101-2021_01_04_425177 42 4 point point NN 10_1101-2021_01_04_425177 42 5 ( ( -LRB- 10_1101-2021_01_04_425177 42 6 pI pI NNP 10_1101-2021_01_04_425177 42 7 ) ) -RRB- 10_1101-2021_01_04_425177 42 8 Molecular molecular JJ 10_1101-2021_01_04_425177 42 9 weight weight NN 10_1101-2021_01_04_425177 42 10 [ [ -LRB- 10_1101-2021_01_04_425177 42 11 g g NN 10_1101-2021_01_04_425177 42 12 mol-1 mol-1 UH 10_1101-2021_01_04_425177 42 13 ] ] -RRB- 10_1101-2021_01_04_425177 42 14 Net net JJ 10_1101-2021_01_04_425177 42 15 charge charge NN 10_1101-2021_01_04_425177 42 16 at at IN 10_1101-2021_01_04_425177 42 17 pH pH NNP 10_1101-2021_01_04_425177 42 18 7 7 CD 10_1101-2021_01_04_425177 42 19 Theoretical theoretical JJ 10_1101-2021_01_04_425177 42 20 hydrophobicity hydrophobicity NN 10_1101-2021_01_04_425177 42 21 [ [ -LRB- 10_1101-2021_01_04_425177 42 22 kcal kcal JJ 10_1101-2021_01_04_425177 42 23 mol-1 mol-1 NNP 10_1101-2021_01_04_425177 42 24 ] ] -RRB- 10_1101-2021_01_04_425177 42 25 huPrP23 huprp23 NN 10_1101-2021_01_04_425177 42 26 - - HYPH 10_1101-2021_01_04_425177 42 27 231 231 CD 10_1101-2021_01_04_425177 42 28 UniProt UniProt NNP 10_1101-2021_01_04_425177 42 29 ID ID NNP 10_1101-2021_01_04_425177 42 30 : : : 10_1101-2021_01_04_425177 42 31 P04156 P04156 NNP 10_1101-2021_01_04_425177 42 32 ( ( -LRB- 10_1101-2021_01_04_425177 42 33 209 209 CD 10_1101-2021_01_04_425177 42 34 aa aa NNP 10_1101-2021_01_04_425177 42 35 ) ) -RRB- 10_1101-2021_01_04_425177 42 36 9.39 9.39 CD 10_1101-2021_01_04_425177 42 37 22747 22747 CD 10_1101-2021_01_04_425177 42 38 +7 +7 CD 10_1101-2021_01_04_425177 42 39 - - HYPH 10_1101-2021_01_04_425177 42 40 NCAM11 ncam11 NN 10_1101-2021_01_04_425177 42 41 - - HYPH 10_1101-2021_01_04_425177 42 42 19-K- 19-K- VBN 10_1101-2021_01_04_425177 42 43 Aβ16 Aβ16 NNP 10_1101-2021_01_04_425177 42 44 - - : 10_1101-2021_01_04_425177 42 45 20 20 CD 10_1101-2021_01_04_425177 42 46 ( ( -LRB- 10_1101-2021_01_04_425177 42 47 NCAM1- NCAM1- NNP 10_1101-2021_01_04_425177 42 48 Aβ Aβ NNP 10_1101-2021_01_04_425177 42 49 ) ) -RRB- 10_1101-2021_01_04_425177 42 50 NH2-MLRTKDLIWTL NH2-MLRTKDLIWTL NNP 10_1101-2021_01_04_425177 42 51 FFLGTAVSKKLVFF- FFLGTAVSKKLVFF- VBD 10_1101-2021_01_04_425177 42 52 NH2 NH2 NNP 10_1101-2021_01_04_425177 42 53 11.67 11.67 CD 10_1101-2021_01_04_425177 42 54 2974.7 2974.7 CD 10_1101-2021_01_04_425177 42 55 +4 +4 CD 10_1101-2021_01_04_425177 42 56 -3.83 -3.83 CD 10_1101-2021_01_04_425177 42 57 NCAM11 NCAM11 NNP 10_1101-2021_01_04_425177 42 58 - - HYPH 10_1101-2021_01_04_425177 42 59 19 19 CD 10_1101-2021_01_04_425177 42 60 ( ( -LRB- 10_1101-2021_01_04_425177 42 61 NCAM1 ncam1 NN 10_1101-2021_01_04_425177 42 62 ) ) -RRB- 10_1101-2021_01_04_425177 42 63 NH2-MLRTKDLIWTL NH2-MLRTKDLIWTL NNP 10_1101-2021_01_04_425177 42 64 FFLGTAVS FFLGTAVS NNP 10_1101-2021_01_04_425177 42 65 - - HYPH 10_1101-2021_01_04_425177 42 66 NH2 NH2 NNP 10_1101-2021_01_04_425177 42 67 11.39 11.39 CD 10_1101-2021_01_04_425177 42 68 2211.7 2211.7 CD 10_1101-2021_01_04_425177 42 69 +2 +2 SYM 10_1101-2021_01_04_425177 42 70 -3.06 -3.06 CD 10_1101-2021_01_04_425177 42 71 KKLVFF KKLVFF NNP 10_1101-2021_01_04_425177 42 72 NH2-KKLVFF NH2-KKLVFF NNP 10_1101-2021_01_04_425177 42 73 - - HYPH 10_1101-2021_01_04_425177 42 74 COOH COOH NNP 10_1101-2021_01_04_425177 42 75 10.69 10.69 CD 10_1101-2021_01_04_425177 42 76 781 781 CD 10_1101-2021_01_04_425177 42 77 +2 +2 JJ 10_1101-2021_01_04_425177 42 78 -0.77 -0.77 CD 10_1101-2021_01_04_425177 42 79 .CC .CC NFP 10_1101-2021_01_04_425177 42 80 - - HYPH 10_1101-2021_01_04_425177 42 81 BY by IN 10_1101-2021_01_04_425177 42 82 - - HYPH 10_1101-2021_01_04_425177 42 83 NC NC NNP 10_1101-2021_01_04_425177 42 84 - - HYPH 10_1101-2021_01_04_425177 42 85 ND ND NNP 10_1101-2021_01_04_425177 42 86 4.0 4.0 CD 10_1101-2021_01_04_425177 42 87 International international JJ 10_1101-2021_01_04_425177 42 88 licensemade licensemade NN 10_1101-2021_01_04_425177 42 89 available available JJ 10_1101-2021_01_04_425177 42 90 under under IN 10_1101-2021_01_04_425177 42 91 a a DT 10_1101-2021_01_04_425177 42 92 ( ( -LRB- 10_1101-2021_01_04_425177 42 93 which which WDT 10_1101-2021_01_04_425177 42 94 was be VBD 10_1101-2021_01_04_425177 42 95 not not RB 10_1101-2021_01_04_425177 42 96 certified certify VBN 10_1101-2021_01_04_425177 42 97 by by IN 10_1101-2021_01_04_425177 42 98 peer peer NN 10_1101-2021_01_04_425177 42 99 review review NN 10_1101-2021_01_04_425177 42 100 ) ) -RRB- 10_1101-2021_01_04_425177 42 101 is be VBZ 10_1101-2021_01_04_425177 42 102 the the DT 10_1101-2021_01_04_425177 42 103 author author NN 10_1101-2021_01_04_425177 42 104 / / SYM 10_1101-2021_01_04_425177 42 105 funder funder NN 10_1101-2021_01_04_425177 42 106 , , , 10_1101-2021_01_04_425177 42 107 who who WP 10_1101-2021_01_04_425177 42 108 has have VBZ 10_1101-2021_01_04_425177 42 109 granted grant VBN 10_1101-2021_01_04_425177 42 110 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 42 111 a a DT 10_1101-2021_01_04_425177 42 112 license license NN 10_1101-2021_01_04_425177 42 113 to to TO 10_1101-2021_01_04_425177 42 114 display display VB 10_1101-2021_01_04_425177 42 115 the the DT 10_1101-2021_01_04_425177 42 116 preprint preprint NN 10_1101-2021_01_04_425177 42 117 in in IN 10_1101-2021_01_04_425177 42 118 perpetuity perpetuity NN 10_1101-2021_01_04_425177 42 119 . . . 10_1101-2021_01_04_425177 43 1 It -PRON- PRP 10_1101-2021_01_04_425177 43 2 is be VBZ 10_1101-2021_01_04_425177 43 3 The the DT 10_1101-2021_01_04_425177 43 4 copyright copyright NN 10_1101-2021_01_04_425177 43 5 holder holder NN 10_1101-2021_01_04_425177 43 6 for for IN 10_1101-2021_01_04_425177 43 7 this this DT 10_1101-2021_01_04_425177 43 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 43 9 version version NN 10_1101-2021_01_04_425177 43 10 posted post VBD 10_1101-2021_01_04_425177 43 11 January January NNP 10_1101-2021_01_04_425177 43 12 4 4 CD 10_1101-2021_01_04_425177 43 13 , , , 10_1101-2021_01_04_425177 43 14 2021 2021 CD 10_1101-2021_01_04_425177 43 15 . . . 10_1101-2021_01_04_425177 43 16 ; ; : 10_1101-2021_01_04_425177 43 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 43 18 : : : 10_1101-2021_01_04_425177 43 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 43 20 preprint preprint NN 10_1101-2021_01_04_425177 43 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 NNP 10_1101-2021_01_04_425177 43 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_04_425177 43 23 5 5 CD 10_1101-2021_01_04_425177 43 24 2 2 CD 10_1101-2021_01_04_425177 43 25 . . . 10_1101-2021_01_04_425177 44 1 Materials material NNS 10_1101-2021_01_04_425177 44 2 and and CC 10_1101-2021_01_04_425177 44 3 Methods method NNS 10_1101-2021_01_04_425177 44 4 2.1 2.1 CD 10_1101-2021_01_04_425177 44 5 Sample Sample NNP 10_1101-2021_01_04_425177 44 6 preparation preparation NN 10_1101-2021_01_04_425177 44 7 Human human JJ 10_1101-2021_01_04_425177 44 8 recombinant recombinant JJ 10_1101-2021_01_04_425177 44 9 prion prion NN 10_1101-2021_01_04_425177 44 10 protein protein NN 10_1101-2021_01_04_425177 44 11 ( ( -LRB- 10_1101-2021_01_04_425177 44 12 huPrP huPrP NNP 10_1101-2021_01_04_425177 44 13 ) ) -RRB- 10_1101-2021_01_04_425177 44 14 was be VBD 10_1101-2021_01_04_425177 44 15 prepared prepare VBN 10_1101-2021_01_04_425177 44 16 according accord VBG 10_1101-2021_01_04_425177 44 17 to to IN 10_1101-2021_01_04_425177 44 18 a a DT 10_1101-2021_01_04_425177 44 19 previously previously RB 10_1101-2021_01_04_425177 44 20 published publish VBN 10_1101-2021_01_04_425177 44 21 protocol protocol NN 10_1101-2021_01_04_425177 44 22 ( ( -LRB- 10_1101-2021_01_04_425177 44 23 Morillas Morillas NNP 10_1101-2021_01_04_425177 44 24 et et NNP 10_1101-2021_01_04_425177 44 25 al al NNP 10_1101-2021_01_04_425177 44 26 . . NNP 10_1101-2021_01_04_425177 44 27 , , , 10_1101-2021_01_04_425177 44 28 1999 1999 CD 10_1101-2021_01_04_425177 44 29 ; ; : 10_1101-2021_01_04_425177 44 30 Zahn Zahn NNP 10_1101-2021_01_04_425177 44 31 et et NNP 10_1101-2021_01_04_425177 44 32 al al NNP 10_1101-2021_01_04_425177 44 33 . . NNP 10_1101-2021_01_04_425177 44 34 , , , 10_1101-2021_01_04_425177 44 35 1997 1997 CD 10_1101-2021_01_04_425177 44 36 ) ) -RRB- 10_1101-2021_01_04_425177 44 37 , , , 10_1101-2021_01_04_425177 44 38 albeit albeit IN 10_1101-2021_01_04_425177 44 39 with with IN 10_1101-2021_01_04_425177 44 40 some some DT 10_1101-2021_01_04_425177 44 41 modifications modification NNS 10_1101-2021_01_04_425177 44 42 . . . 10_1101-2021_01_04_425177 45 1 The the DT 10_1101-2021_01_04_425177 45 2 plasmid plasmid NN 10_1101-2021_01_04_425177 45 3 contained contain VBD 10_1101-2021_01_04_425177 45 4 the the DT 10_1101-2021_01_04_425177 45 5 full full JJ 10_1101-2021_01_04_425177 45 6 - - HYPH 10_1101-2021_01_04_425177 45 7 length length NN 10_1101-2021_01_04_425177 45 8 ( ( -LRB- 10_1101-2021_01_04_425177 45 9 23 23 CD 10_1101-2021_01_04_425177 45 10 - - HYPH 10_1101-2021_01_04_425177 45 11 231)huPrP 231)huprp CD 10_1101-2021_01_04_425177 45 12 protein protein NN 10_1101-2021_01_04_425177 45 13 in in IN 10_1101-2021_01_04_425177 45 14 fusion fusion NN 10_1101-2021_01_04_425177 45 15 with with IN 10_1101-2021_01_04_425177 45 16 an an DT 10_1101-2021_01_04_425177 45 17 N n NN 10_1101-2021_01_04_425177 45 18 - - HYPH 10_1101-2021_01_04_425177 45 19 terminal terminal NN 10_1101-2021_01_04_425177 45 20 HisTag HisTag NNP 10_1101-2021_01_04_425177 45 21 , , , 10_1101-2021_01_04_425177 45 22 and and CC 10_1101-2021_01_04_425177 45 23 the the DT 10_1101-2021_01_04_425177 45 24 thrombin thrombin NN 10_1101-2021_01_04_425177 45 25 cleavage cleavage NN 10_1101-2021_01_04_425177 45 26 site site NN 10_1101-2021_01_04_425177 45 27 was be VBD 10_1101-2021_01_04_425177 45 28 cloned clone VBN 10_1101-2021_01_04_425177 45 29 into into IN 10_1101-2021_01_04_425177 45 30 the the DT 10_1101-2021_01_04_425177 45 31 pRSETB prsetb NN 10_1101-2021_01_04_425177 45 32 vector vector NN 10_1101-2021_01_04_425177 45 33 ( ( -LRB- 10_1101-2021_01_04_425177 45 34 Invitrogen Invitrogen NNP 10_1101-2021_01_04_425177 45 35 , , , 10_1101-2021_01_04_425177 45 36 USA USA NNP 10_1101-2021_01_04_425177 45 37 ) ) -RRB- 10_1101-2021_01_04_425177 45 38 . . . 10_1101-2021_01_04_425177 46 1 The the DT 10_1101-2021_01_04_425177 46 2 construct construct NN 10_1101-2021_01_04_425177 46 3 was be VBD 10_1101-2021_01_04_425177 46 4 expressed express VBN 10_1101-2021_01_04_425177 46 5 in in IN 10_1101-2021_01_04_425177 46 6 E. E. NNP 10_1101-2021_01_04_425177 46 7 Coli Coli NNP 10_1101-2021_01_04_425177 46 8 ( ( -LRB- 10_1101-2021_01_04_425177 46 9 BL21- BL21- `` 10_1101-2021_01_04_425177 46 10 DE3 DE3 NNP 10_1101-2021_01_04_425177 46 11 ) ) -RRB- 10_1101-2021_01_04_425177 46 12 grown grow VBN 10_1101-2021_01_04_425177 46 13 in in IN 10_1101-2021_01_04_425177 46 14 LB LB NNP 10_1101-2021_01_04_425177 46 15 growth growth NN 10_1101-2021_01_04_425177 46 16 medium medium NN 10_1101-2021_01_04_425177 46 17 with with IN 10_1101-2021_01_04_425177 46 18 100 100 CD 10_1101-2021_01_04_425177 46 19 µg µg NNS 10_1101-2021_01_04_425177 46 20 / / SYM 10_1101-2021_01_04_425177 46 21 mL mL NNP 10_1101-2021_01_04_425177 46 22 ampicillin ampicillin NNP 10_1101-2021_01_04_425177 46 23 . . . 10_1101-2021_01_04_425177 47 1 Expression expression NN 10_1101-2021_01_04_425177 47 2 was be VBD 10_1101-2021_01_04_425177 47 3 induced induce VBN 10_1101-2021_01_04_425177 47 4 by by IN 10_1101-2021_01_04_425177 47 5 isopropyl isopropyl JJ 10_1101-2021_01_04_425177 47 6 β β NNP 10_1101-2021_01_04_425177 47 7 - - HYPH 10_1101-2021_01_04_425177 47 8 D D NNP 10_1101-2021_01_04_425177 47 9 - - HYPH 10_1101-2021_01_04_425177 47 10 galactopyranoside galactopyranoside NN 10_1101-2021_01_04_425177 47 11 ( ( -LRB- 10_1101-2021_01_04_425177 47 12 IPTG iptg NN 10_1101-2021_01_04_425177 47 13 ) ) -RRB- 10_1101-2021_01_04_425177 47 14 at at IN 10_1101-2021_01_04_425177 47 15 OD600 od600 NN 10_1101-2021_01_04_425177 47 16 = = SYM 10_1101-2021_01_04_425177 47 17 0.8 0.8 CD 10_1101-2021_01_04_425177 47 18 . . . 10_1101-2021_01_04_425177 48 1 Sonication sonication NN 10_1101-2021_01_04_425177 48 2 of of IN 10_1101-2021_01_04_425177 48 3 the the DT 10_1101-2021_01_04_425177 48 4 lysates lysate NNS 10_1101-2021_01_04_425177 48 5 was be VBD 10_1101-2021_01_04_425177 48 6 performed perform VBN 10_1101-2021_01_04_425177 48 7 in in IN 10_1101-2021_01_04_425177 48 8 a a DT 10_1101-2021_01_04_425177 48 9 buffer buffer NN 10_1101-2021_01_04_425177 48 10 containing contain VBG 10_1101-2021_01_04_425177 48 11 100 100 CD 10_1101-2021_01_04_425177 48 12 mM mm NN 10_1101-2021_01_04_425177 48 13 Tris Tris NNP 10_1101-2021_01_04_425177 48 14 at at IN 10_1101-2021_01_04_425177 48 15 pH pH NNP 10_1101-2021_01_04_425177 48 16 8 8 CD 10_1101-2021_01_04_425177 48 17 , , , 10_1101-2021_01_04_425177 48 18 10 10 CD 10_1101-2021_01_04_425177 48 19 mM mm NN 10_1101-2021_01_04_425177 48 20 K2HPO4 k2hpo4 NN 10_1101-2021_01_04_425177 48 21 , , , 10_1101-2021_01_04_425177 48 22 10 10 CD 10_1101-2021_01_04_425177 48 23 mM mm NN 10_1101-2021_01_04_425177 48 24 glutathione glutathione NN 10_1101-2021_01_04_425177 48 25 ( ( -LRB- 10_1101-2021_01_04_425177 48 26 GSH GSH NNP 10_1101-2021_01_04_425177 48 27 ) ) -RRB- 10_1101-2021_01_04_425177 48 28 , , , 10_1101-2021_01_04_425177 48 29 6 6 CD 10_1101-2021_01_04_425177 48 30 M m NN 10_1101-2021_01_04_425177 48 31 GuHCl GuHCl NNS 10_1101-2021_01_04_425177 48 32 , , , 10_1101-2021_01_04_425177 48 33 and and CC 10_1101-2021_01_04_425177 48 34 0.5 0.5 CD 10_1101-2021_01_04_425177 48 35 mM mm NN 10_1101-2021_01_04_425177 48 36 phenylmethane phenylmethane NN 10_1101-2021_01_04_425177 48 37 sulfonyl sulfonyl NN 10_1101-2021_01_04_425177 48 38 fluoride fluoride NN 10_1101-2021_01_04_425177 48 39 ( ( -LRB- 10_1101-2021_01_04_425177 48 40 PMSF PMSF NNP 10_1101-2021_01_04_425177 48 41 ) ) -RRB- 10_1101-2021_01_04_425177 48 42 . . . 10_1101-2021_01_04_425177 49 1 The the DT 10_1101-2021_01_04_425177 49 2 solution solution NN 10_1101-2021_01_04_425177 49 3 was be VBD 10_1101-2021_01_04_425177 49 4 centrifuged centrifuge VBN 10_1101-2021_01_04_425177 49 5 and and CC 10_1101-2021_01_04_425177 49 6 the the DT 10_1101-2021_01_04_425177 49 7 supernatant supernatant JJ 10_1101-2021_01_04_425177 49 8 loaded load VBN 10_1101-2021_01_04_425177 49 9 to to IN 10_1101-2021_01_04_425177 49 10 Ni Ni NNP 10_1101-2021_01_04_425177 49 11 - - HYPH 10_1101-2021_01_04_425177 49 12 NTA NTA NNP 10_1101-2021_01_04_425177 49 13 resin resin NN 10_1101-2021_01_04_425177 49 14 ( ( -LRB- 10_1101-2021_01_04_425177 49 15 GE GE NNP 10_1101-2021_01_04_425177 49 16 Healthcare Healthcare NNP 10_1101-2021_01_04_425177 49 17 ) ) -RRB- 10_1101-2021_01_04_425177 49 18 and and CC 10_1101-2021_01_04_425177 49 19 eluted elute VBN 10_1101-2021_01_04_425177 49 20 with with IN 10_1101-2021_01_04_425177 49 21 buffer buffer NN 10_1101-2021_01_04_425177 49 22 E e NN 10_1101-2021_01_04_425177 49 23 ( ( -LRB- 10_1101-2021_01_04_425177 49 24 100 100 CD 10_1101-2021_01_04_425177 49 25 mM mm NN 10_1101-2021_01_04_425177 49 26 Tris Tris NNP 10_1101-2021_01_04_425177 49 27 at at IN 10_1101-2021_01_04_425177 49 28 pH pH NNP 10_1101-2021_01_04_425177 49 29 5.8 5.8 CD 10_1101-2021_01_04_425177 49 30 , , , 10_1101-2021_01_04_425177 49 31 10 10 CD 10_1101-2021_01_04_425177 49 32 mM mm NN 10_1101-2021_01_04_425177 49 33 K2HPO4 k2hpo4 NN 10_1101-2021_01_04_425177 49 34 , , , 10_1101-2021_01_04_425177 49 35 and and CC 10_1101-2021_01_04_425177 49 36 500 500 CD 10_1101-2021_01_04_425177 49 37 mM mM NNP 10_1101-2021_01_04_425177 49 38 imidazole imidazole NN 10_1101-2021_01_04_425177 49 39 ) ) -RRB- 10_1101-2021_01_04_425177 49 40 . . . 10_1101-2021_01_04_425177 50 1 After after IN 10_1101-2021_01_04_425177 50 2 washing wash VBG 10_1101-2021_01_04_425177 50 3 the the DT 10_1101-2021_01_04_425177 50 4 resin resin NN 10_1101-2021_01_04_425177 50 5 , , , 10_1101-2021_01_04_425177 50 6 the the DT 10_1101-2021_01_04_425177 50 7 protein protein NN 10_1101-2021_01_04_425177 50 8 was be VBD 10_1101-2021_01_04_425177 50 9 purified purify VBN 10_1101-2021_01_04_425177 50 10 with with IN 10_1101-2021_01_04_425177 50 11 two- two- NN 10_1101-2021_01_04_425177 50 12 step step NN 10_1101-2021_01_04_425177 50 13 dialysis dialysis NN 10_1101-2021_01_04_425177 50 14 , , , 10_1101-2021_01_04_425177 50 15 initially initially RB 10_1101-2021_01_04_425177 50 16 against against IN 10_1101-2021_01_04_425177 50 17 10 10 CD 10_1101-2021_01_04_425177 50 18 mM mM NNP 10_1101-2021_01_04_425177 50 19 phosphate phosphate NN 10_1101-2021_01_04_425177 50 20 buffer buffer NN 10_1101-2021_01_04_425177 50 21 with with IN 10_1101-2021_01_04_425177 50 22 0.1 0.1 CD 10_1101-2021_01_04_425177 50 23 mM mm NN 10_1101-2021_01_04_425177 50 24 PMSF pmsf NN 10_1101-2021_01_04_425177 50 25 at at IN 10_1101-2021_01_04_425177 50 26 pH pH NNP 10_1101-2021_01_04_425177 50 27 5.8 5.8 CD 10_1101-2021_01_04_425177 50 28 , , , 10_1101-2021_01_04_425177 50 29 and and CC 10_1101-2021_01_04_425177 50 30 then then RB 10_1101-2021_01_04_425177 50 31 against against IN 10_1101-2021_01_04_425177 50 32 Milli Milli NNP 10_1101-2021_01_04_425177 50 33 - - HYPH 10_1101-2021_01_04_425177 50 34 Q Q NNP 10_1101-2021_01_04_425177 50 35 H2O h2o NN 10_1101-2021_01_04_425177 50 36 with with IN 10_1101-2021_01_04_425177 50 37 0.1 0.1 CD 10_1101-2021_01_04_425177 50 38 mM mm NN 10_1101-2021_01_04_425177 50 39 PMSF pmsf JJ 10_1101-2021_01_04_425177 50 40 . . . 10_1101-2021_01_04_425177 51 1 After after IN 10_1101-2021_01_04_425177 51 2 thrombin thrombin NN 10_1101-2021_01_04_425177 51 3 cleavage cleavage NN 10_1101-2021_01_04_425177 51 4 , , , 10_1101-2021_01_04_425177 51 5 the the DT 10_1101-2021_01_04_425177 51 6 pure pure JJ 10_1101-2021_01_04_425177 51 7 huPrP huprp NN 10_1101-2021_01_04_425177 51 8 protein protein NN 10_1101-2021_01_04_425177 51 9 ( ( -LRB- 10_1101-2021_01_04_425177 51 10 i.e. i.e. FW 10_1101-2021_01_04_425177 51 11 , , , 10_1101-2021_01_04_425177 51 12 with with IN 10_1101-2021_01_04_425177 51 13 the the DT 10_1101-2021_01_04_425177 51 14 HisTag HisTag NNP 10_1101-2021_01_04_425177 51 15 removed remove VBN 10_1101-2021_01_04_425177 51 16 ) ) -RRB- 10_1101-2021_01_04_425177 51 17 was be VBD 10_1101-2021_01_04_425177 51 18 concentrated concentrate VBN 10_1101-2021_01_04_425177 51 19 using use VBG 10_1101-2021_01_04_425177 51 20 an an DT 10_1101-2021_01_04_425177 51 21 Amicon Amicon NNP 10_1101-2021_01_04_425177 51 22 Ultra Ultra NNP 10_1101-2021_01_04_425177 51 23 0.5 0.5 CD 10_1101-2021_01_04_425177 51 24 ml ml NN 10_1101-2021_01_04_425177 51 25 centrifugal centrifugal JJ 10_1101-2021_01_04_425177 51 26 filter filter NN 10_1101-2021_01_04_425177 51 27 ( ( -LRB- 10_1101-2021_01_04_425177 51 28 Merck Merck NNP 10_1101-2021_01_04_425177 51 29 & & CC 10_1101-2021_01_04_425177 51 30 Co. Co. NNP 10_1101-2021_01_04_425177 51 31 , , , 10_1101-2021_01_04_425177 51 32 USA USA NNP 10_1101-2021_01_04_425177 51 33 ) ) -RRB- 10_1101-2021_01_04_425177 51 34 with with IN 10_1101-2021_01_04_425177 51 35 an an DT 10_1101-2021_01_04_425177 51 36 NMWL NMWL NNP 10_1101-2021_01_04_425177 51 37 cutoff cutoff NN 10_1101-2021_01_04_425177 51 38 of of IN 10_1101-2021_01_04_425177 51 39 3 3 CD 10_1101-2021_01_04_425177 51 40 kDa kDa NNS 10_1101-2021_01_04_425177 51 41 . . . 10_1101-2021_01_04_425177 52 1 The the DT 10_1101-2021_01_04_425177 52 2 final final JJ 10_1101-2021_01_04_425177 52 3 protein protein NN 10_1101-2021_01_04_425177 52 4 concentration concentration NN 10_1101-2021_01_04_425177 52 5 was be VBD 10_1101-2021_01_04_425177 52 6 determined determine VBN 10_1101-2021_01_04_425177 52 7 by by IN 10_1101-2021_01_04_425177 52 8 spectrophotometry spectrophotometry NNP 10_1101-2021_01_04_425177 52 9 using use VBG 10_1101-2021_01_04_425177 52 10 an an DT 10_1101-2021_01_04_425177 52 11 extinction extinction NN 10_1101-2021_01_04_425177 52 12 coefficient coefficient NN 10_1101-2021_01_04_425177 52 13 of of IN 10_1101-2021_01_04_425177 52 14 ε280 ε280 NNP 10_1101-2021_01_04_425177 52 15 = = NFP 10_1101-2021_01_04_425177 52 16 57995 57995 CD 10_1101-2021_01_04_425177 52 17 M m NN 10_1101-2021_01_04_425177 52 18 -1cm-1 -1cm-1 : 10_1101-2021_01_04_425177 52 19 ( ( -LRB- 10_1101-2021_01_04_425177 52 20 Gasteiger Gasteiger NNP 10_1101-2021_01_04_425177 52 21 et et FW 10_1101-2021_01_04_425177 52 22 al al NNP 10_1101-2021_01_04_425177 52 23 . . NNP 10_1101-2021_01_04_425177 52 24 , , , 10_1101-2021_01_04_425177 52 25 2005 2005 CD 10_1101-2021_01_04_425177 52 26 ) ) -RRB- 10_1101-2021_01_04_425177 52 27 . . . 10_1101-2021_01_04_425177 53 1 The the DT 10_1101-2021_01_04_425177 53 2 quality quality NN 10_1101-2021_01_04_425177 53 3 of of IN 10_1101-2021_01_04_425177 53 4 the the DT 10_1101-2021_01_04_425177 53 5 final final JJ 10_1101-2021_01_04_425177 53 6 protein protein NN 10_1101-2021_01_04_425177 53 7 was be VBD 10_1101-2021_01_04_425177 53 8 controlled control VBN 10_1101-2021_01_04_425177 53 9 by by IN 10_1101-2021_01_04_425177 53 10 mass mass NNP 10_1101-2021_01_04_425177 53 11 spectrometry spectrometry NNP 10_1101-2021_01_04_425177 53 12 ( ( -LRB- 10_1101-2021_01_04_425177 53 13 molecular molecular NNP 10_1101-2021_01_04_425177 53 14 mass mass NN 10_1101-2021_01_04_425177 53 15 22747 22747 CD 10_1101-2021_01_04_425177 53 16 Da Da NNP 10_1101-2021_01_04_425177 53 17 - - HYPH 10_1101-2021_01_04_425177 53 18 Table Table NNP 10_1101-2021_01_04_425177 53 19 1 1 CD 10_1101-2021_01_04_425177 53 20 ) ) -RRB- 10_1101-2021_01_04_425177 53 21 . . . 10_1101-2021_01_04_425177 54 1 The the DT 10_1101-2021_01_04_425177 54 2 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 54 3 peptide peptide NN 10_1101-2021_01_04_425177 54 4 ( ( -LRB- 10_1101-2021_01_04_425177 54 5 Table table NN 10_1101-2021_01_04_425177 54 6 1 1 CD 10_1101-2021_01_04_425177 54 7 ) ) -RRB- 10_1101-2021_01_04_425177 54 8 was be VBD 10_1101-2021_01_04_425177 54 9 purchased purchase VBN 10_1101-2021_01_04_425177 54 10 as as IN 10_1101-2021_01_04_425177 54 11 a a DT 10_1101-2021_01_04_425177 54 12 custom custom NN 10_1101-2021_01_04_425177 54 13 order order NN 10_1101-2021_01_04_425177 54 14 from from IN 10_1101-2021_01_04_425177 54 15 the the DT 10_1101-2021_01_04_425177 54 16 PolyPeptide PolyPeptide NNP 10_1101-2021_01_04_425177 54 17 Group Group NNP 10_1101-2021_01_04_425177 54 18 ( ( -LRB- 10_1101-2021_01_04_425177 54 19 France France NNP 10_1101-2021_01_04_425177 54 20 ) ) -RRB- 10_1101-2021_01_04_425177 54 21 in in IN 10_1101-2021_01_04_425177 54 22 lyophilized lyophilize VBN 10_1101-2021_01_04_425177 54 23 form form NN 10_1101-2021_01_04_425177 54 24 . . . 10_1101-2021_01_04_425177 55 1 The the DT 10_1101-2021_01_04_425177 55 2 peptide peptide NN 10_1101-2021_01_04_425177 55 3 was be VBD 10_1101-2021_01_04_425177 55 4 dissolved dissolve VBN 10_1101-2021_01_04_425177 55 5 in in IN 10_1101-2021_01_04_425177 55 6 Milli Milli NNP 10_1101-2021_01_04_425177 55 7 - - HYPH 10_1101-2021_01_04_425177 55 8 Q Q NNP 10_1101-2021_01_04_425177 55 9 water water NN 10_1101-2021_01_04_425177 55 10 , , , 10_1101-2021_01_04_425177 55 11 and and CC 10_1101-2021_01_04_425177 55 12 its -PRON- PRP$ 10_1101-2021_01_04_425177 55 13 concentration concentration NN 10_1101-2021_01_04_425177 55 14 was be VBD 10_1101-2021_01_04_425177 55 15 determined determine VBN 10_1101-2021_01_04_425177 55 16 via via IN 10_1101-2021_01_04_425177 55 17 triplicate triplicate NN 10_1101-2021_01_04_425177 55 18 UV uv NN 10_1101-2021_01_04_425177 55 19 absorption absorption NN 10_1101-2021_01_04_425177 55 20 measurements measurement NNS 10_1101-2021_01_04_425177 55 21 at at IN 10_1101-2021_01_04_425177 55 22 280 280 CD 10_1101-2021_01_04_425177 55 23 nm nm UH 10_1101-2021_01_04_425177 55 24 , , , 10_1101-2021_01_04_425177 55 25 using use VBG 10_1101-2021_01_04_425177 55 26 a a DT 10_1101-2021_01_04_425177 55 27 DS-11 DS-11 NNP 10_1101-2021_01_04_425177 55 28 spectrophotometer spectrophotometer NN 10_1101-2021_01_04_425177 55 29 ( ( -LRB- 10_1101-2021_01_04_425177 55 30 DeNovix DeNovix NNP 10_1101-2021_01_04_425177 55 31 , , , 10_1101-2021_01_04_425177 55 32 USA USA NNP 10_1101-2021_01_04_425177 55 33 ) ) -RRB- 10_1101-2021_01_04_425177 55 34 and and CC 10_1101-2021_01_04_425177 55 35 an an DT 10_1101-2021_01_04_425177 55 36 extinction extinction NN 10_1101-2021_01_04_425177 55 37 coefficient coefficient NN 10_1101-2021_01_04_425177 55 38 of of IN 10_1101-2021_01_04_425177 55 39 ε280 ε280 NNP 10_1101-2021_01_04_425177 55 40 = = NN 10_1101-2021_01_04_425177 55 41 5500 5500 CD 10_1101-2021_01_04_425177 55 42 M m NN 10_1101-2021_01_04_425177 55 43 -1cm-1 -1cm-1 : 10_1101-2021_01_04_425177 55 44 ( ( -LRB- 10_1101-2021_01_04_425177 55 45 Gasteiger Gasteiger NNP 10_1101-2021_01_04_425177 55 46 et et FW 10_1101-2021_01_04_425177 55 47 al al NNP 10_1101-2021_01_04_425177 55 48 . . NNP 10_1101-2021_01_04_425177 55 49 , , , 10_1101-2021_01_04_425177 55 50 2005 2005 CD 10_1101-2021_01_04_425177 55 51 ) ) -RRB- 10_1101-2021_01_04_425177 55 52 . . . 10_1101-2021_01_04_425177 56 1 .CC .CC NFP 10_1101-2021_01_04_425177 56 2 - - : 10_1101-2021_01_04_425177 56 3 BY by IN 10_1101-2021_01_04_425177 56 4 - - HYPH 10_1101-2021_01_04_425177 56 5 NC NC NNP 10_1101-2021_01_04_425177 56 6 - - HYPH 10_1101-2021_01_04_425177 56 7 ND ND NNP 10_1101-2021_01_04_425177 56 8 4.0 4.0 CD 10_1101-2021_01_04_425177 56 9 International international JJ 10_1101-2021_01_04_425177 56 10 licensemade licensemade NN 10_1101-2021_01_04_425177 56 11 available available JJ 10_1101-2021_01_04_425177 56 12 under under IN 10_1101-2021_01_04_425177 56 13 a a DT 10_1101-2021_01_04_425177 56 14 ( ( -LRB- 10_1101-2021_01_04_425177 56 15 which which WDT 10_1101-2021_01_04_425177 56 16 was be VBD 10_1101-2021_01_04_425177 56 17 not not RB 10_1101-2021_01_04_425177 56 18 certified certify VBN 10_1101-2021_01_04_425177 56 19 by by IN 10_1101-2021_01_04_425177 56 20 peer peer NN 10_1101-2021_01_04_425177 56 21 review review NN 10_1101-2021_01_04_425177 56 22 ) ) -RRB- 10_1101-2021_01_04_425177 56 23 is be VBZ 10_1101-2021_01_04_425177 56 24 the the DT 10_1101-2021_01_04_425177 56 25 author author NN 10_1101-2021_01_04_425177 56 26 / / SYM 10_1101-2021_01_04_425177 56 27 funder funder NN 10_1101-2021_01_04_425177 56 28 , , , 10_1101-2021_01_04_425177 56 29 who who WP 10_1101-2021_01_04_425177 56 30 has have VBZ 10_1101-2021_01_04_425177 56 31 granted grant VBN 10_1101-2021_01_04_425177 56 32 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 56 33 a a DT 10_1101-2021_01_04_425177 56 34 license license NN 10_1101-2021_01_04_425177 56 35 to to TO 10_1101-2021_01_04_425177 56 36 display display VB 10_1101-2021_01_04_425177 56 37 the the DT 10_1101-2021_01_04_425177 56 38 preprint preprint NN 10_1101-2021_01_04_425177 56 39 in in IN 10_1101-2021_01_04_425177 56 40 perpetuity perpetuity NN 10_1101-2021_01_04_425177 56 41 . . . 10_1101-2021_01_04_425177 57 1 It -PRON- PRP 10_1101-2021_01_04_425177 57 2 is be VBZ 10_1101-2021_01_04_425177 57 3 The the DT 10_1101-2021_01_04_425177 57 4 copyright copyright NN 10_1101-2021_01_04_425177 57 5 holder holder NN 10_1101-2021_01_04_425177 57 6 for for IN 10_1101-2021_01_04_425177 57 7 this this DT 10_1101-2021_01_04_425177 57 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 57 9 version version NN 10_1101-2021_01_04_425177 57 10 posted post VBD 10_1101-2021_01_04_425177 57 11 January January NNP 10_1101-2021_01_04_425177 57 12 4 4 CD 10_1101-2021_01_04_425177 57 13 , , , 10_1101-2021_01_04_425177 57 14 2021 2021 CD 10_1101-2021_01_04_425177 57 15 . . . 10_1101-2021_01_04_425177 57 16 ; ; : 10_1101-2021_01_04_425177 57 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 57 18 : : : 10_1101-2021_01_04_425177 57 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 57 20 preprint preprint NN 10_1101-2021_01_04_425177 57 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 VBZ 10_1101-2021_01_04_425177 57 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_04_425177 57 23 6 6 CD 10_1101-2021_01_04_425177 57 24 2.2 2.2 CD 10_1101-2021_01_04_425177 57 25 Sample sample NN 10_1101-2021_01_04_425177 57 26 incubation incubation NN 10_1101-2021_01_04_425177 57 27 The the DT 10_1101-2021_01_04_425177 57 28 initial initial JJ 10_1101-2021_01_04_425177 57 29 buffer buffer NN 10_1101-2021_01_04_425177 57 30 in in IN 10_1101-2021_01_04_425177 57 31 the the DT 10_1101-2021_01_04_425177 57 32 huPrP huprp NN 10_1101-2021_01_04_425177 57 33 solution solution NN 10_1101-2021_01_04_425177 57 34 was be VBD 10_1101-2021_01_04_425177 57 35 exchanged exchange VBN 10_1101-2021_01_04_425177 57 36 to to TO 10_1101-2021_01_04_425177 57 37 ultrapure ultrapure VB 10_1101-2021_01_04_425177 57 38 water water NN 10_1101-2021_01_04_425177 57 39 by by IN 10_1101-2021_01_04_425177 57 40 triplicate triplicate NN 10_1101-2021_01_04_425177 57 41 diafiltration diafiltration NN 10_1101-2021_01_04_425177 57 42 using use VBG 10_1101-2021_01_04_425177 57 43 an an DT 10_1101-2021_01_04_425177 57 44 Amicon Amicon NNP 10_1101-2021_01_04_425177 57 45 Ultra Ultra NNP 10_1101-2021_01_04_425177 57 46 0.5 0.5 CD 10_1101-2021_01_04_425177 57 47 ml ml NN 10_1101-2021_01_04_425177 57 48 centrifugal centrifugal JJ 10_1101-2021_01_04_425177 57 49 filter filter NN 10_1101-2021_01_04_425177 57 50 ( ( -LRB- 10_1101-2021_01_04_425177 57 51 Merck Merck NNP 10_1101-2021_01_04_425177 57 52 & & CC 10_1101-2021_01_04_425177 57 53 Co. Co. NNP 10_1101-2021_01_04_425177 57 54 , , , 10_1101-2021_01_04_425177 57 55 USA USA NNP 10_1101-2021_01_04_425177 57 56 ) ) -RRB- 10_1101-2021_01_04_425177 57 57 with with IN 10_1101-2021_01_04_425177 57 58 an an DT 10_1101-2021_01_04_425177 57 59 NMWL NMWL NNP 10_1101-2021_01_04_425177 57 60 cutoff cutoff NN 10_1101-2021_01_04_425177 57 61 of of IN 10_1101-2021_01_04_425177 57 62 3 3 CD 10_1101-2021_01_04_425177 57 63 kDa kDa NNS 10_1101-2021_01_04_425177 57 64 . . . 10_1101-2021_01_04_425177 58 1 Samples sample NNS 10_1101-2021_01_04_425177 58 2 of of IN 10_1101-2021_01_04_425177 58 3 0.5 0.5 CD 10_1101-2021_01_04_425177 58 4 µM µM NNP 10_1101-2021_01_04_425177 58 5 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 58 6 , , , 10_1101-2021_01_04_425177 58 7 2.5 2.5 CD 10_1101-2021_01_04_425177 58 8 µM µM NNP 10_1101-2021_01_04_425177 58 9 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 58 10 , , , 10_1101-2021_01_04_425177 58 11 0.5 0.5 CD 10_1101-2021_01_04_425177 58 12 µM µM NNP 10_1101-2021_01_04_425177 58 13 huPrP huprp NN 10_1101-2021_01_04_425177 58 14 , , , 10_1101-2021_01_04_425177 58 15 and and CC 10_1101-2021_01_04_425177 58 16 0.5 0.5 CD 10_1101-2021_01_04_425177 58 17 µM µM NNP 10_1101-2021_01_04_425177 58 18 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 58 19 + + NNP 10_1101-2021_01_04_425177 58 20 0.5 0.5 CD 10_1101-2021_01_04_425177 58 21 µM µM NNP 10_1101-2021_01_04_425177 58 22 huPrP huPrP NNS 10_1101-2021_01_04_425177 58 23 were be VBD 10_1101-2021_01_04_425177 58 24 then then RB 10_1101-2021_01_04_425177 58 25 prepared prepare VBN 10_1101-2021_01_04_425177 58 26 in in IN 10_1101-2021_01_04_425177 58 27 10 10 CD 10_1101-2021_01_04_425177 58 28 mM mm NN 10_1101-2021_01_04_425177 58 29 sodium sodium NN 10_1101-2021_01_04_425177 58 30 phosphate phosphate NN 10_1101-2021_01_04_425177 58 31 buffer buffer NN 10_1101-2021_01_04_425177 58 32 , , , 10_1101-2021_01_04_425177 58 33 pH pH NNP 10_1101-2021_01_04_425177 58 34 7.5 7.5 CD 10_1101-2021_01_04_425177 58 35 , , , 10_1101-2021_01_04_425177 58 36 with with IN 10_1101-2021_01_04_425177 58 37 100 100 CD 10_1101-2021_01_04_425177 58 38 mM mm NN 10_1101-2021_01_04_425177 58 39 NaCl NaCl NNP 10_1101-2021_01_04_425177 58 40 and and CC 10_1101-2021_01_04_425177 58 41 2 2 CD 10_1101-2021_01_04_425177 58 42 M M NNP 10_1101-2021_01_04_425177 58 43 urea urea NNP 10_1101-2021_01_04_425177 58 44 . . . 10_1101-2021_01_04_425177 59 1 The the DT 10_1101-2021_01_04_425177 59 2 urea urea NN 10_1101-2021_01_04_425177 59 3 was be VBD 10_1101-2021_01_04_425177 59 4 added add VBN 10_1101-2021_01_04_425177 59 5 as as IN 10_1101-2021_01_04_425177 59 6 it -PRON- PRP 10_1101-2021_01_04_425177 59 7 has have VBZ 10_1101-2021_01_04_425177 59 8 previously previously RB 10_1101-2021_01_04_425177 59 9 been be VBN 10_1101-2021_01_04_425177 59 10 shown show VBN 10_1101-2021_01_04_425177 59 11 to to TO 10_1101-2021_01_04_425177 59 12 promote promote VB 10_1101-2021_01_04_425177 59 13 unfolding unfolding NN 10_1101-2021_01_04_425177 59 14 of of IN 10_1101-2021_01_04_425177 59 15 the the DT 10_1101-2021_01_04_425177 59 16 native native JJ 10_1101-2021_01_04_425177 59 17 PrP PrP NNP 10_1101-2021_01_04_425177 59 18 structure structure NN 10_1101-2021_01_04_425177 59 19 , , , 10_1101-2021_01_04_425177 59 20 which which WDT 10_1101-2021_01_04_425177 59 21 is be VBZ 10_1101-2021_01_04_425177 59 22 the the DT 10_1101-2021_01_04_425177 59 23 first first JJ 10_1101-2021_01_04_425177 59 24 step step NN 10_1101-2021_01_04_425177 59 25 towards towards IN 10_1101-2021_01_04_425177 59 26 aggregation aggregation NN 10_1101-2021_01_04_425177 59 27 ( ( -LRB- 10_1101-2021_01_04_425177 59 28 Julien Julien NNP 10_1101-2021_01_04_425177 59 29 et et NNP 10_1101-2021_01_04_425177 59 30 al al NNP 10_1101-2021_01_04_425177 59 31 . . NNP 10_1101-2021_01_04_425177 59 32 , , , 10_1101-2021_01_04_425177 59 33 2009 2009 CD 10_1101-2021_01_04_425177 59 34 ; ; : 10_1101-2021_01_04_425177 59 35 Swietnicki Swietnicki NNP 10_1101-2021_01_04_425177 59 36 et et FW 10_1101-2021_01_04_425177 59 37 al al NNP 10_1101-2021_01_04_425177 59 38 . . NNP 10_1101-2021_01_04_425177 59 39 , , , 10_1101-2021_01_04_425177 59 40 2000 2000 CD 10_1101-2021_01_04_425177 59 41 ) ) -RRB- 10_1101-2021_01_04_425177 59 42 . . . 10_1101-2021_01_04_425177 60 1 The the DT 10_1101-2021_01_04_425177 60 2 samples sample NNS 10_1101-2021_01_04_425177 60 3 were be VBD 10_1101-2021_01_04_425177 60 4 incubated incubate VBN 10_1101-2021_01_04_425177 60 5 for for IN 10_1101-2021_01_04_425177 60 6 72 72 CD 10_1101-2021_01_04_425177 60 7 hours hour NNS 10_1101-2021_01_04_425177 60 8 at at IN 10_1101-2021_01_04_425177 60 9 50 50 CD 10_1101-2021_01_04_425177 60 10 ℃ ℃ NN 10_1101-2021_01_04_425177 60 11 with with IN 10_1101-2021_01_04_425177 60 12 magnetic magnetic JJ 10_1101-2021_01_04_425177 60 13 stirring stirring NN 10_1101-2021_01_04_425177 60 14 at at IN 10_1101-2021_01_04_425177 60 15 400 400 CD 10_1101-2021_01_04_425177 60 16 rpm rpm NN 10_1101-2021_01_04_425177 60 17 . . . 10_1101-2021_01_04_425177 61 1 Subsamples subsample NNS 10_1101-2021_01_04_425177 61 2 were be VBD 10_1101-2021_01_04_425177 61 3 taken take VBN 10_1101-2021_01_04_425177 61 4 out out RP 10_1101-2021_01_04_425177 61 5 for for IN 10_1101-2021_01_04_425177 61 6 AFM AFM NNP 10_1101-2021_01_04_425177 61 7 imaging imaging NN 10_1101-2021_01_04_425177 61 8 ( ( -LRB- 10_1101-2021_01_04_425177 61 9 below below RB 10_1101-2021_01_04_425177 61 10 ) ) -RRB- 10_1101-2021_01_04_425177 61 11 after after IN 10_1101-2021_01_04_425177 61 12 8 8 CD 10_1101-2021_01_04_425177 61 13 and and CC 10_1101-2021_01_04_425177 61 14 72 72 CD 10_1101-2021_01_04_425177 61 15 hours hour NNS 10_1101-2021_01_04_425177 61 16 , , , 10_1101-2021_01_04_425177 61 17 respectively respectively RB 10_1101-2021_01_04_425177 61 18 . . . 10_1101-2021_01_04_425177 62 1 2.3 2.3 CD 10_1101-2021_01_04_425177 62 2 Atomic atomic JJ 10_1101-2021_01_04_425177 62 3 force force NN 10_1101-2021_01_04_425177 62 4 microscopy microscopy JJ 10_1101-2021_01_04_425177 62 5 ( ( -LRB- 10_1101-2021_01_04_425177 62 6 AFM AFM NNP 10_1101-2021_01_04_425177 62 7 ) ) -RRB- 10_1101-2021_01_04_425177 62 8 imaging image VBG 10_1101-2021_01_04_425177 62 9 Incubated incubate VBN 10_1101-2021_01_04_425177 62 10 samples sample NNS 10_1101-2021_01_04_425177 62 11 ( ( -LRB- 10_1101-2021_01_04_425177 62 12 5 5 CD 10_1101-2021_01_04_425177 62 13 μl μl NN 10_1101-2021_01_04_425177 62 14 ) ) -RRB- 10_1101-2021_01_04_425177 62 15 were be VBD 10_1101-2021_01_04_425177 62 16 transferred transfer VBN 10_1101-2021_01_04_425177 62 17 to to TO 10_1101-2021_01_04_425177 62 18 freshly freshly RB 10_1101-2021_01_04_425177 62 19 cleaved cleave VBN 10_1101-2021_01_04_425177 62 20 mica mica NNP 10_1101-2021_01_04_425177 62 21 plates plate NNS 10_1101-2021_01_04_425177 62 22 and and CC 10_1101-2021_01_04_425177 62 23 left leave VBD 10_1101-2021_01_04_425177 62 24 to to TO 10_1101-2021_01_04_425177 62 25 absorb absorb VB 10_1101-2021_01_04_425177 62 26 for for IN 10_1101-2021_01_04_425177 62 27 1 1 CD 10_1101-2021_01_04_425177 62 28 min min NN 10_1101-2021_01_04_425177 62 29 , , , 10_1101-2021_01_04_425177 62 30 rinsed rinse VBN 10_1101-2021_01_04_425177 62 31 three three CD 10_1101-2021_01_04_425177 62 32 times time NNS 10_1101-2021_01_04_425177 62 33 with with IN 10_1101-2021_01_04_425177 62 34 300 300 CD 10_1101-2021_01_04_425177 62 35 μl μl NN 10_1101-2021_01_04_425177 62 36 of of IN 10_1101-2021_01_04_425177 62 37 pure pure JJ 10_1101-2021_01_04_425177 62 38 water water NN 10_1101-2021_01_04_425177 62 39 , , , 10_1101-2021_01_04_425177 62 40 and and CC 10_1101-2021_01_04_425177 62 41 then then RB 10_1101-2021_01_04_425177 62 42 dried dry VBN 10_1101-2021_01_04_425177 62 43 under under IN 10_1101-2021_01_04_425177 62 44 a a DT 10_1101-2021_01_04_425177 62 45 gentle gentle JJ 10_1101-2021_01_04_425177 62 46 flow flow NN 10_1101-2021_01_04_425177 62 47 of of IN 10_1101-2021_01_04_425177 62 48 nitrogen nitrogen NN 10_1101-2021_01_04_425177 62 49 . . . 10_1101-2021_01_04_425177 63 1 AFM AFM NNP 10_1101-2021_01_04_425177 63 2 imaging imaging NNP 10_1101-2021_01_04_425177 63 3 was be VBD 10_1101-2021_01_04_425177 63 4 performed perform VBN 10_1101-2021_01_04_425177 63 5 on on IN 10_1101-2021_01_04_425177 63 6 a a DT 10_1101-2021_01_04_425177 63 7 JPK JPK NNP 10_1101-2021_01_04_425177 63 8 Nanowizard Nanowizard NNP 10_1101-2021_01_04_425177 63 9 4 4 CD 10_1101-2021_01_04_425177 63 10 ( ( -LRB- 10_1101-2021_01_04_425177 63 11 Bruker Bruker NNP 10_1101-2021_01_04_425177 63 12 , , , 10_1101-2021_01_04_425177 63 13 Germany Germany NNP 10_1101-2021_01_04_425177 63 14 ) ) -RRB- 10_1101-2021_01_04_425177 63 15 AFM AFM NNP 10_1101-2021_01_04_425177 63 16 unit unit NN 10_1101-2021_01_04_425177 63 17 using use VBG 10_1101-2021_01_04_425177 63 18 Tap150Al Tap150Al NNP 10_1101-2021_01_04_425177 63 19 - - HYPH 10_1101-2021_01_04_425177 63 20 G g NN 10_1101-2021_01_04_425177 63 21 cantilevers cantilever NNS 10_1101-2021_01_04_425177 63 22 ( ( -LRB- 10_1101-2021_01_04_425177 63 23 Ted Ted NNP 10_1101-2021_01_04_425177 63 24 Pella Pella NNP 10_1101-2021_01_04_425177 63 25 Inc. Inc. NNP 10_1101-2021_01_04_425177 63 26 , , , 10_1101-2021_01_04_425177 63 27 USA USA NNP 10_1101-2021_01_04_425177 63 28 ) ) -RRB- 10_1101-2021_01_04_425177 63 29 in in IN 10_1101-2021_01_04_425177 63 30 air air NN 10_1101-2021_01_04_425177 63 31 intermittent intermittent JJ 10_1101-2021_01_04_425177 63 32 contact contact NN 10_1101-2021_01_04_425177 63 33 mode mode NN 10_1101-2021_01_04_425177 63 34 . . . 10_1101-2021_01_04_425177 64 1 The the DT 10_1101-2021_01_04_425177 64 2 scan scan JJ 10_1101-2021_01_04_425177 64 3 rate rate NN 10_1101-2021_01_04_425177 64 4 was be VBD 10_1101-2021_01_04_425177 64 5 0.3 0.3 CD 10_1101-2021_01_04_425177 64 6 - - SYM 10_1101-2021_01_04_425177 64 7 0.7 0.7 CD 10_1101-2021_01_04_425177 64 8 Hz Hz NNP 10_1101-2021_01_04_425177 64 9 , , , 10_1101-2021_01_04_425177 64 10 the the DT 10_1101-2021_01_04_425177 64 11 scan scan JJ 10_1101-2021_01_04_425177 64 12 area area NN 10_1101-2021_01_04_425177 64 13 size size NN 10_1101-2021_01_04_425177 64 14 was be VBD 10_1101-2021_01_04_425177 64 15 5 5 CD 10_1101-2021_01_04_425177 64 16 μm μm NNS 10_1101-2021_01_04_425177 64 17 x x SYM 10_1101-2021_01_04_425177 64 18 5 5 CD 10_1101-2021_01_04_425177 64 19 μm μm NNS 10_1101-2021_01_04_425177 64 20 or or CC 10_1101-2021_01_04_425177 64 21 10 10 CD 10_1101-2021_01_04_425177 64 22 μm μm NNS 10_1101-2021_01_04_425177 64 23 x x SYM 10_1101-2021_01_04_425177 64 24 10 10 CD 10_1101-2021_01_04_425177 64 25 μm μm NNS 10_1101-2021_01_04_425177 64 26 , , , 10_1101-2021_01_04_425177 64 27 with with IN 10_1101-2021_01_04_425177 64 28 512 512 CD 10_1101-2021_01_04_425177 64 29 x x SYM 10_1101-2021_01_04_425177 64 30 512 512 CD 10_1101-2021_01_04_425177 64 31 or or CC 10_1101-2021_01_04_425177 64 32 1024 1024 CD 10_1101-2021_01_04_425177 64 33 x x SYM 10_1101-2021_01_04_425177 64 34 1024 1024 CD 10_1101-2021_01_04_425177 64 35 pixel pixel NNP 10_1101-2021_01_04_425177 64 36 resolution resolution NN 10_1101-2021_01_04_425177 64 37 respectively respectively RB 10_1101-2021_01_04_425177 64 38 . . . 10_1101-2021_01_04_425177 65 1 The the DT 10_1101-2021_01_04_425177 65 2 AFM afm NN 10_1101-2021_01_04_425177 65 3 images image NNS 10_1101-2021_01_04_425177 65 4 were be VBD 10_1101-2021_01_04_425177 65 5 analyzed analyze VBN 10_1101-2021_01_04_425177 65 6 using use VBG 10_1101-2021_01_04_425177 65 7 the the DT 10_1101-2021_01_04_425177 65 8 Gwyddion Gwyddion NNP 10_1101-2021_01_04_425177 65 9 2.54 2.54 CD 10_1101-2021_01_04_425177 65 10 software software NN 10_1101-2021_01_04_425177 65 11 ( ( -LRB- 10_1101-2021_01_04_425177 65 12 Necas Necas NNP 10_1101-2021_01_04_425177 65 13 and and CC 10_1101-2021_01_04_425177 65 14 Klapetek Klapetek NNP 10_1101-2021_01_04_425177 65 15 , , , 10_1101-2021_01_04_425177 65 16 2012 2012 CD 10_1101-2021_01_04_425177 65 17 ) ) -RRB- 10_1101-2021_01_04_425177 65 18 . . . 10_1101-2021_01_04_425177 66 1 3 3 LS 10_1101-2021_01_04_425177 66 2 . . . 10_1101-2021_01_04_425177 67 1 Results result NNS 10_1101-2021_01_04_425177 67 2 and and CC 10_1101-2021_01_04_425177 67 3 Discussion Discussion NNP 10_1101-2021_01_04_425177 67 4 AFM AFM NNP 10_1101-2021_01_04_425177 67 5 images image NNS 10_1101-2021_01_04_425177 67 6 of of IN 10_1101-2021_01_04_425177 67 7 the the DT 10_1101-2021_01_04_425177 67 8 aggregation aggregation NN 10_1101-2021_01_04_425177 67 9 products product NNS 10_1101-2021_01_04_425177 67 10 present present JJ 10_1101-2021_01_04_425177 67 11 in in IN 10_1101-2021_01_04_425177 67 12 the the DT 10_1101-2021_01_04_425177 67 13 samples sample NNS 10_1101-2021_01_04_425177 67 14 after after IN 10_1101-2021_01_04_425177 67 15 8 8 CD 10_1101-2021_01_04_425177 67 16 hours hour NNS 10_1101-2021_01_04_425177 67 17 of of IN 10_1101-2021_01_04_425177 67 18 incubation incubation NN 10_1101-2021_01_04_425177 67 19 are be VBP 10_1101-2021_01_04_425177 67 20 shown show VBN 10_1101-2021_01_04_425177 67 21 in in IN 10_1101-2021_01_04_425177 67 22 Figs Figs NNP 10_1101-2021_01_04_425177 67 23 . . . 10_1101-2021_01_04_425177 68 1 1A 1a LS 10_1101-2021_01_04_425177 68 2 - - HYPH 10_1101-2021_01_04_425177 68 3 D. D. NNP 10_1101-2021_01_04_425177 69 1 The the DT 10_1101-2021_01_04_425177 69 2 sample sample NN 10_1101-2021_01_04_425177 69 3 of of IN 10_1101-2021_01_04_425177 69 4 0.5 0.5 CD 10_1101-2021_01_04_425177 69 5 µM µM NNP 10_1101-2021_01_04_425177 69 6 huPrP huPrP NNP 10_1101-2021_01_04_425177 69 7 readily readily RB 10_1101-2021_01_04_425177 69 8 self- self- VBD 10_1101-2021_01_04_425177 69 9 aggregated aggregate VBN 10_1101-2021_01_04_425177 69 10 into into IN 10_1101-2021_01_04_425177 69 11 long long JJ 10_1101-2021_01_04_425177 69 12 fibrils fibril NNS 10_1101-2021_01_04_425177 69 13 ( ( -LRB- 10_1101-2021_01_04_425177 69 14 Fig fig NN 10_1101-2021_01_04_425177 69 15 . . . 10_1101-2021_01_04_425177 70 1 1A 1a LS 10_1101-2021_01_04_425177 70 2 ) ) -RRB- 10_1101-2021_01_04_425177 70 3 that that WDT 10_1101-2021_01_04_425177 70 4 are be VBP 10_1101-2021_01_04_425177 70 5 approximately approximately RB 10_1101-2021_01_04_425177 70 6 3 3 CD 10_1101-2021_01_04_425177 70 7 - - SYM 10_1101-2021_01_04_425177 70 8 4 4 CD 10_1101-2021_01_04_425177 70 9 nm nm NN 10_1101-2021_01_04_425177 70 10 thick thick JJ 10_1101-2021_01_04_425177 70 11 ( ( -LRB- 10_1101-2021_01_04_425177 70 12 judged judge VBN 10_1101-2021_01_04_425177 70 13 by by IN 10_1101-2021_01_04_425177 70 14 their -PRON- PRP$ 10_1101-2021_01_04_425177 70 15 measured measure VBN 10_1101-2021_01_04_425177 70 16 height height NN 10_1101-2021_01_04_425177 70 17 , , , 10_1101-2021_01_04_425177 70 18 as as IN 10_1101-2021_01_04_425177 70 19 width width NN 10_1101-2021_01_04_425177 70 20 is be VBZ 10_1101-2021_01_04_425177 70 21 not not RB 10_1101-2021_01_04_425177 70 22 accurately accurately RB 10_1101-2021_01_04_425177 70 23 represented represent VBN 10_1101-2021_01_04_425177 70 24 in in IN 10_1101-2021_01_04_425177 70 25 AFM AFM NNP 10_1101-2021_01_04_425177 70 26 images image NNS 10_1101-2021_01_04_425177 70 27 ) ) -RRB- 10_1101-2021_01_04_425177 70 28 . . . 10_1101-2021_01_04_425177 71 1 This this DT 10_1101-2021_01_04_425177 71 2 is be VBZ 10_1101-2021_01_04_425177 71 3 somewhat somewhat RB 10_1101-2021_01_04_425177 71 4 thinner thin JJR 10_1101-2021_01_04_425177 71 5 but but CC 10_1101-2021_01_04_425177 71 6 still still RB 10_1101-2021_01_04_425177 71 7 in in IN 10_1101-2021_01_04_425177 71 8 line line NN 10_1101-2021_01_04_425177 71 9 with with IN 10_1101-2021_01_04_425177 71 10 the the DT 10_1101-2021_01_04_425177 71 11 results result NNS 10_1101-2021_01_04_425177 71 12 of of IN 10_1101-2021_01_04_425177 71 13 previous previous JJ 10_1101-2021_01_04_425177 71 14 studies study NNS 10_1101-2021_01_04_425177 71 15 on on IN 10_1101-2021_01_04_425177 71 16 PrP PrP NNP 10_1101-2021_01_04_425177 71 17 fibrils fibril NNS 10_1101-2021_01_04_425177 71 18 ( ( -LRB- 10_1101-2021_01_04_425177 71 19 Terry Terry NNP 10_1101-2021_01_04_425177 71 20 and and CC 10_1101-2021_01_04_425177 71 21 Wadsworth Wadsworth NNP 10_1101-2021_01_04_425177 71 22 , , , 10_1101-2021_01_04_425177 71 23 2019 2019 CD 10_1101-2021_01_04_425177 71 24 ; ; : 10_1101-2021_01_04_425177 71 25 Vazquez Vazquez NNP 10_1101-2021_01_04_425177 71 26 - - HYPH 10_1101-2021_01_04_425177 71 27 Fernandez Fernandez NNP 10_1101-2021_01_04_425177 71 28 et et FW 10_1101-2021_01_04_425177 71 29 al al NNP 10_1101-2021_01_04_425177 71 30 . . NNP 10_1101-2021_01_04_425177 71 31 , , , 10_1101-2021_01_04_425177 71 32 2017 2017 CD 10_1101-2021_01_04_425177 71 33 ; ; : 10_1101-2021_01_04_425177 71 34 Yamaguchi Yamaguchi NNP 10_1101-2021_01_04_425177 71 35 and and CC 10_1101-2021_01_04_425177 71 36 Kuwata Kuwata NNP 10_1101-2021_01_04_425177 71 37 , , , 10_1101-2021_01_04_425177 71 38 2018 2018 CD 10_1101-2021_01_04_425177 71 39 ) ) -RRB- 10_1101-2021_01_04_425177 71 40 . . . 10_1101-2021_01_04_425177 72 1 A a DT 10_1101-2021_01_04_425177 72 2 few few JJ 10_1101-2021_01_04_425177 72 3 very very RB 10_1101-2021_01_04_425177 72 4 large large JJ 10_1101-2021_01_04_425177 72 5 aggregate aggregate JJ 10_1101-2021_01_04_425177 72 6 clumps clump NNS 10_1101-2021_01_04_425177 72 7 , , , 10_1101-2021_01_04_425177 72 8 over over IN 10_1101-2021_01_04_425177 72 9 10 10 CD 10_1101-2021_01_04_425177 72 10 nm nm IN 10_1101-2021_01_04_425177 72 11 high high JJ 10_1101-2021_01_04_425177 72 12 , , , 10_1101-2021_01_04_425177 72 13 can can MD 10_1101-2021_01_04_425177 72 14 also also RB 10_1101-2021_01_04_425177 72 15 be be VB 10_1101-2021_01_04_425177 72 16 seen see VBN 10_1101-2021_01_04_425177 72 17 ( ( -LRB- 10_1101-2021_01_04_425177 72 18 Fig fig NN 10_1101-2021_01_04_425177 72 19 . . . 10_1101-2021_01_04_425177 73 1 1A 1a LS 10_1101-2021_01_04_425177 73 2 ) ) -RRB- 10_1101-2021_01_04_425177 73 3 . . . 10_1101-2021_01_04_425177 74 1 For for IN 10_1101-2021_01_04_425177 74 2 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 74 3 , , , 10_1101-2021_01_04_425177 74 4 the the DT 10_1101-2021_01_04_425177 74 5 0.5 0.5 CD 10_1101-2021_01_04_425177 74 6 µM µM NNP 10_1101-2021_01_04_425177 74 7 sample sample NN 10_1101-2021_01_04_425177 74 8 shows show VBZ 10_1101-2021_01_04_425177 74 9 small small JJ 10_1101-2021_01_04_425177 74 10 aggregate aggregate NN 10_1101-2021_01_04_425177 74 11 clumps clump NNS 10_1101-2021_01_04_425177 74 12 ( ( -LRB- 10_1101-2021_01_04_425177 74 13 Fig fig NN 10_1101-2021_01_04_425177 74 14 .CC .CC : 10_1101-2021_01_04_425177 74 15 - - : 10_1101-2021_01_04_425177 74 16 BY by IN 10_1101-2021_01_04_425177 74 17 - - HYPH 10_1101-2021_01_04_425177 74 18 NC NC NNP 10_1101-2021_01_04_425177 74 19 - - HYPH 10_1101-2021_01_04_425177 74 20 ND ND NNP 10_1101-2021_01_04_425177 74 21 4.0 4.0 CD 10_1101-2021_01_04_425177 74 22 International international JJ 10_1101-2021_01_04_425177 74 23 licensemade licensemade NN 10_1101-2021_01_04_425177 74 24 available available JJ 10_1101-2021_01_04_425177 74 25 under under IN 10_1101-2021_01_04_425177 74 26 a a DT 10_1101-2021_01_04_425177 74 27 ( ( -LRB- 10_1101-2021_01_04_425177 74 28 which which WDT 10_1101-2021_01_04_425177 74 29 was be VBD 10_1101-2021_01_04_425177 74 30 not not RB 10_1101-2021_01_04_425177 74 31 certified certify VBN 10_1101-2021_01_04_425177 74 32 by by IN 10_1101-2021_01_04_425177 74 33 peer peer NN 10_1101-2021_01_04_425177 74 34 review review NN 10_1101-2021_01_04_425177 74 35 ) ) -RRB- 10_1101-2021_01_04_425177 74 36 is be VBZ 10_1101-2021_01_04_425177 74 37 the the DT 10_1101-2021_01_04_425177 74 38 author author NN 10_1101-2021_01_04_425177 74 39 / / SYM 10_1101-2021_01_04_425177 74 40 funder funder NN 10_1101-2021_01_04_425177 74 41 , , , 10_1101-2021_01_04_425177 74 42 who who WP 10_1101-2021_01_04_425177 74 43 has have VBZ 10_1101-2021_01_04_425177 74 44 granted grant VBN 10_1101-2021_01_04_425177 74 45 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 74 46 a a DT 10_1101-2021_01_04_425177 74 47 license license NN 10_1101-2021_01_04_425177 74 48 to to TO 10_1101-2021_01_04_425177 74 49 display display VB 10_1101-2021_01_04_425177 74 50 the the DT 10_1101-2021_01_04_425177 74 51 preprint preprint NN 10_1101-2021_01_04_425177 74 52 in in IN 10_1101-2021_01_04_425177 74 53 perpetuity perpetuity NN 10_1101-2021_01_04_425177 74 54 . . . 10_1101-2021_01_04_425177 75 1 It -PRON- PRP 10_1101-2021_01_04_425177 75 2 is be VBZ 10_1101-2021_01_04_425177 75 3 The the DT 10_1101-2021_01_04_425177 75 4 copyright copyright NN 10_1101-2021_01_04_425177 75 5 holder holder NN 10_1101-2021_01_04_425177 75 6 for for IN 10_1101-2021_01_04_425177 75 7 this this DT 10_1101-2021_01_04_425177 75 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 75 9 version version NN 10_1101-2021_01_04_425177 75 10 posted post VBD 10_1101-2021_01_04_425177 75 11 January January NNP 10_1101-2021_01_04_425177 75 12 4 4 CD 10_1101-2021_01_04_425177 75 13 , , , 10_1101-2021_01_04_425177 75 14 2021 2021 CD 10_1101-2021_01_04_425177 75 15 . . . 10_1101-2021_01_04_425177 75 16 ; ; : 10_1101-2021_01_04_425177 75 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 75 18 : : : 10_1101-2021_01_04_425177 75 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 75 20 preprint preprint NN 10_1101-2021_01_04_425177 75 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 NNP 10_1101-2021_01_04_425177 75 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NNP 10_1101-2021_01_04_425177 75 23 7 7 CD 10_1101-2021_01_04_425177 75 24 1B 1b NN 10_1101-2021_01_04_425177 75 25 ) ) -RRB- 10_1101-2021_01_04_425177 75 26 . . . 10_1101-2021_01_04_425177 76 1 Some some DT 10_1101-2021_01_04_425177 76 2 of of IN 10_1101-2021_01_04_425177 76 3 them -PRON- PRP 10_1101-2021_01_04_425177 76 4 are be VBP 10_1101-2021_01_04_425177 76 5 relatively relatively RB 10_1101-2021_01_04_425177 76 6 large large JJ 10_1101-2021_01_04_425177 76 7 , , , 10_1101-2021_01_04_425177 76 8 with with IN 10_1101-2021_01_04_425177 76 9 heights height NNS 10_1101-2021_01_04_425177 76 10 over over IN 10_1101-2021_01_04_425177 76 11 6 6 CD 10_1101-2021_01_04_425177 76 12 nm nm CD 10_1101-2021_01_04_425177 76 13 , , , 10_1101-2021_01_04_425177 76 14 and and CC 10_1101-2021_01_04_425177 76 15 may may MD 10_1101-2021_01_04_425177 76 16 or or CC 10_1101-2021_01_04_425177 76 17 may may MD 10_1101-2021_01_04_425177 76 18 not not RB 10_1101-2021_01_04_425177 76 19 be be VB 10_1101-2021_01_04_425177 76 20 early early JJ 10_1101-2021_01_04_425177 76 21 stages stage NNS 10_1101-2021_01_04_425177 76 22 of of IN 10_1101-2021_01_04_425177 76 23 fibrillar fibrillar JJ 10_1101-2021_01_04_425177 76 24 aggregates aggregate NNS 10_1101-2021_01_04_425177 76 25 ( ( -LRB- 10_1101-2021_01_04_425177 76 26 Luo Luo NNP 10_1101-2021_01_04_425177 76 27 et et NNP 10_1101-2021_01_04_425177 76 28 al al NNP 10_1101-2021_01_04_425177 76 29 . . NNP 10_1101-2021_01_04_425177 76 30 , , , 10_1101-2021_01_04_425177 76 31 2014 2014 CD 10_1101-2021_01_04_425177 76 32 ) ) -RRB- 10_1101-2021_01_04_425177 76 33 . . . 10_1101-2021_01_04_425177 77 1 The the DT 10_1101-2021_01_04_425177 77 2 2.5 2.5 CD 10_1101-2021_01_04_425177 77 3 µM µM NNP 10_1101-2021_01_04_425177 77 4 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 77 5 sample sample NN 10_1101-2021_01_04_425177 77 6 shows show VBZ 10_1101-2021_01_04_425177 77 7 numerous numerous JJ 10_1101-2021_01_04_425177 77 8 mature mature JJ 10_1101-2021_01_04_425177 77 9 fibrils fibril NNS 10_1101-2021_01_04_425177 77 10 , , , 10_1101-2021_01_04_425177 77 11 about about RB 10_1101-2021_01_04_425177 77 12 2 2 CD 10_1101-2021_01_04_425177 77 13 – – SYM 10_1101-2021_01_04_425177 77 14 3 3 CD 10_1101-2021_01_04_425177 77 15 nm nm CC 10_1101-2021_01_04_425177 77 16 high high JJ 10_1101-2021_01_04_425177 77 17 , , , 10_1101-2021_01_04_425177 77 18 together together RB 10_1101-2021_01_04_425177 77 19 with with IN 10_1101-2021_01_04_425177 77 20 aggregate aggregate JJ 10_1101-2021_01_04_425177 77 21 clumps clump NNS 10_1101-2021_01_04_425177 77 22 ( ( -LRB- 10_1101-2021_01_04_425177 77 23 Fig fig NN 10_1101-2021_01_04_425177 77 24 . . . 10_1101-2021_01_04_425177 78 1 1C 1C NNP 10_1101-2021_01_04_425177 78 2 ) ) -RRB- 10_1101-2021_01_04_425177 78 3 . . . 10_1101-2021_01_04_425177 79 1 The the DT 10_1101-2021_01_04_425177 79 2 more more RBR 10_1101-2021_01_04_425177 79 3 abundant abundant JJ 10_1101-2021_01_04_425177 79 4 amount amount NN 10_1101-2021_01_04_425177 79 5 of of IN 10_1101-2021_01_04_425177 79 6 fibrils fibril NNS 10_1101-2021_01_04_425177 79 7 for for IN 10_1101-2021_01_04_425177 79 8 2.5 2.5 CD 10_1101-2021_01_04_425177 79 9 µM µM NNP 10_1101-2021_01_04_425177 79 10 of of IN 10_1101-2021_01_04_425177 79 11 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 79 12 confirms confirm VBZ 10_1101-2021_01_04_425177 79 13 earlier early JJR 10_1101-2021_01_04_425177 79 14 results result NNS 10_1101-2021_01_04_425177 79 15 showing show VBG 10_1101-2021_01_04_425177 79 16 that that IN 10_1101-2021_01_04_425177 79 17 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 79 18 self self NN 10_1101-2021_01_04_425177 79 19 - - HYPH 10_1101-2021_01_04_425177 79 20 aggregates aggregate NNS 10_1101-2021_01_04_425177 79 21 faster fast RBR 10_1101-2021_01_04_425177 79 22 at at IN 10_1101-2021_01_04_425177 79 23 higher high JJR 10_1101-2021_01_04_425177 79 24 concentrations concentration NNS 10_1101-2021_01_04_425177 79 25 ( ( -LRB- 10_1101-2021_01_04_425177 79 26 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 79 27 et et FW 10_1101-2021_01_04_425177 79 28 al al NNP 10_1101-2021_01_04_425177 79 29 . . NNP 10_1101-2021_01_04_425177 79 30 , , , 10_1101-2021_01_04_425177 79 31 2019 2019 CD 10_1101-2021_01_04_425177 79 32 ) ) -RRB- 10_1101-2021_01_04_425177 79 33 . . . 10_1101-2021_01_04_425177 80 1 Figure figure NN 10_1101-2021_01_04_425177 80 2 1 1 CD 10_1101-2021_01_04_425177 80 3 . . . 10_1101-2021_01_04_425177 81 1 AFM afm NN 10_1101-2021_01_04_425177 81 2 images image NNS 10_1101-2021_01_04_425177 81 3 of of IN 10_1101-2021_01_04_425177 81 4 : : : 10_1101-2021_01_04_425177 81 5 ( ( -LRB- 10_1101-2021_01_04_425177 81 6 A a NN 10_1101-2021_01_04_425177 81 7 ) ) -RRB- 10_1101-2021_01_04_425177 81 8 0.5 0.5 CD 10_1101-2021_01_04_425177 81 9 µM µm NN 10_1101-2021_01_04_425177 81 10 huPrP huprp NN 10_1101-2021_01_04_425177 81 11 protein protein NN 10_1101-2021_01_04_425177 81 12 ; ; . 10_1101-2021_01_04_425177 81 13 ( ( -LRB- 10_1101-2021_01_04_425177 81 14 B b NN 10_1101-2021_01_04_425177 81 15 ) ) -RRB- 10_1101-2021_01_04_425177 81 16 0.5 0.5 CD 10_1101-2021_01_04_425177 81 17 µM µM NNP 10_1101-2021_01_04_425177 81 18 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 81 19 peptide peptide NN 10_1101-2021_01_04_425177 81 20 ; ; , 10_1101-2021_01_04_425177 81 21 ( ( -LRB- 10_1101-2021_01_04_425177 81 22 C c NN 10_1101-2021_01_04_425177 81 23 ) ) -RRB- 10_1101-2021_01_04_425177 81 24 2.5 2.5 CD 10_1101-2021_01_04_425177 81 25 µM µM NNP 10_1101-2021_01_04_425177 81 26 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 81 27 peptide peptide NN 10_1101-2021_01_04_425177 81 28 ; ; , 10_1101-2021_01_04_425177 81 29 and and CC 10_1101-2021_01_04_425177 81 30 ( ( -LRB- 10_1101-2021_01_04_425177 81 31 D d NN 10_1101-2021_01_04_425177 81 32 ) ) -RRB- 10_1101-2021_01_04_425177 81 33 0.5 0.5 CD 10_1101-2021_01_04_425177 81 34 µM µm NN 10_1101-2021_01_04_425177 81 35 huPrP huprp NN 10_1101-2021_01_04_425177 81 36 protein protein NN 10_1101-2021_01_04_425177 81 37 + + SYM 10_1101-2021_01_04_425177 81 38 0.5 0.5 CD 10_1101-2021_01_04_425177 81 39 µM µM NNP 10_1101-2021_01_04_425177 81 40 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 81 41 peptide peptide NN 10_1101-2021_01_04_425177 81 42 . . . 10_1101-2021_01_04_425177 82 1 All all DT 10_1101-2021_01_04_425177 82 2 samples sample NNS 10_1101-2021_01_04_425177 82 3 in in IN 10_1101-2021_01_04_425177 82 4 A a NN 10_1101-2021_01_04_425177 82 5 - - HYPH 10_1101-2021_01_04_425177 82 6 D D NNP 10_1101-2021_01_04_425177 82 7 were be VBD 10_1101-2021_01_04_425177 82 8 incubated incubate VBN 10_1101-2021_01_04_425177 82 9 for for IN 10_1101-2021_01_04_425177 82 10 8 8 CD 10_1101-2021_01_04_425177 82 11 hours hour NNS 10_1101-2021_01_04_425177 82 12 . . . 10_1101-2021_01_04_425177 83 1 ( ( -LRB- 10_1101-2021_01_04_425177 83 2 E e NN 10_1101-2021_01_04_425177 83 3 ) ) -RRB- 10_1101-2021_01_04_425177 83 4 0.5 0.5 CD 10_1101-2021_01_04_425177 83 5 µM µm NN 10_1101-2021_01_04_425177 83 6 huPrP huprp NN 10_1101-2021_01_04_425177 83 7 protein protein NN 10_1101-2021_01_04_425177 83 8 + + SYM 10_1101-2021_01_04_425177 83 9 0.5 0.5 CD 10_1101-2021_01_04_425177 83 10 µM µM NNP 10_1101-2021_01_04_425177 83 11 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 83 12 peptide peptide NN 10_1101-2021_01_04_425177 83 13 , , , 10_1101-2021_01_04_425177 83 14 incubated incubate VBD 10_1101-2021_01_04_425177 83 15 for for IN 10_1101-2021_01_04_425177 83 16 72 72 CD 10_1101-2021_01_04_425177 83 17 hours hour NNS 10_1101-2021_01_04_425177 83 18 . . . 10_1101-2021_01_04_425177 84 1 All all DT 10_1101-2021_01_04_425177 84 2 studied study VBN 10_1101-2021_01_04_425177 84 3 samples sample NNS 10_1101-2021_01_04_425177 84 4 were be VBD 10_1101-2021_01_04_425177 84 5 incubated incubate VBN 10_1101-2021_01_04_425177 84 6 at at IN 10_1101-2021_01_04_425177 84 7 50 50 CD 10_1101-2021_01_04_425177 84 8 ℃ ℃ NNP 10_1101-2021_01_04_425177 84 9 in in IN 10_1101-2021_01_04_425177 84 10 10 10 CD 10_1101-2021_01_04_425177 84 11 mM mm NN 10_1101-2021_01_04_425177 84 12 sodium sodium NN 10_1101-2021_01_04_425177 84 13 phosphate phosphate NN 10_1101-2021_01_04_425177 84 14 buffer buffer NN 10_1101-2021_01_04_425177 84 15 , , , 10_1101-2021_01_04_425177 84 16 pH pH NNP 10_1101-2021_01_04_425177 84 17 7.5 7.5 CD 10_1101-2021_01_04_425177 84 18 , , , 10_1101-2021_01_04_425177 84 19 with with IN 10_1101-2021_01_04_425177 84 20 100 100 CD 10_1101-2021_01_04_425177 84 21 mM mm NN 10_1101-2021_01_04_425177 84 22 NaCl NaCl NNP 10_1101-2021_01_04_425177 84 23 and and CC 10_1101-2021_01_04_425177 84 24 2 2 CD 10_1101-2021_01_04_425177 84 25 M M NNP 10_1101-2021_01_04_425177 84 26 urea urea NN 10_1101-2021_01_04_425177 84 27 , , , 10_1101-2021_01_04_425177 84 28 and and CC 10_1101-2021_01_04_425177 84 29 with with IN 10_1101-2021_01_04_425177 84 30 magnetic magnetic JJ 10_1101-2021_01_04_425177 84 31 stirring stirring NN 10_1101-2021_01_04_425177 84 32 at at IN 10_1101-2021_01_04_425177 84 33 400 400 CD 10_1101-2021_01_04_425177 84 34 rpm rpm NN 10_1101-2021_01_04_425177 84 35 . . . 10_1101-2021_01_04_425177 85 1 The the DT 10_1101-2021_01_04_425177 85 2 white white JJ 10_1101-2021_01_04_425177 85 3 scale scale NN 10_1101-2021_01_04_425177 85 4 bars bar NNS 10_1101-2021_01_04_425177 85 5 are be VBP 10_1101-2021_01_04_425177 85 6 500 500 CD 10_1101-2021_01_04_425177 85 7 nm nm NN 10_1101-2021_01_04_425177 85 8 . . . 10_1101-2021_01_04_425177 86 1 .CC .CC NFP 10_1101-2021_01_04_425177 86 2 - - : 10_1101-2021_01_04_425177 86 3 BY by IN 10_1101-2021_01_04_425177 86 4 - - HYPH 10_1101-2021_01_04_425177 86 5 NC NC NNP 10_1101-2021_01_04_425177 86 6 - - HYPH 10_1101-2021_01_04_425177 86 7 ND ND NNP 10_1101-2021_01_04_425177 86 8 4.0 4.0 CD 10_1101-2021_01_04_425177 86 9 International international JJ 10_1101-2021_01_04_425177 86 10 licensemade licensemade NN 10_1101-2021_01_04_425177 86 11 available available JJ 10_1101-2021_01_04_425177 86 12 under under IN 10_1101-2021_01_04_425177 86 13 a a DT 10_1101-2021_01_04_425177 86 14 ( ( -LRB- 10_1101-2021_01_04_425177 86 15 which which WDT 10_1101-2021_01_04_425177 86 16 was be VBD 10_1101-2021_01_04_425177 86 17 not not RB 10_1101-2021_01_04_425177 86 18 certified certify VBN 10_1101-2021_01_04_425177 86 19 by by IN 10_1101-2021_01_04_425177 86 20 peer peer NN 10_1101-2021_01_04_425177 86 21 review review NN 10_1101-2021_01_04_425177 86 22 ) ) -RRB- 10_1101-2021_01_04_425177 86 23 is be VBZ 10_1101-2021_01_04_425177 86 24 the the DT 10_1101-2021_01_04_425177 86 25 author author NN 10_1101-2021_01_04_425177 86 26 / / SYM 10_1101-2021_01_04_425177 86 27 funder funder NN 10_1101-2021_01_04_425177 86 28 , , , 10_1101-2021_01_04_425177 86 29 who who WP 10_1101-2021_01_04_425177 86 30 has have VBZ 10_1101-2021_01_04_425177 86 31 granted grant VBN 10_1101-2021_01_04_425177 86 32 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 86 33 a a DT 10_1101-2021_01_04_425177 86 34 license license NN 10_1101-2021_01_04_425177 86 35 to to TO 10_1101-2021_01_04_425177 86 36 display display VB 10_1101-2021_01_04_425177 86 37 the the DT 10_1101-2021_01_04_425177 86 38 preprint preprint NN 10_1101-2021_01_04_425177 86 39 in in IN 10_1101-2021_01_04_425177 86 40 perpetuity perpetuity NN 10_1101-2021_01_04_425177 86 41 . . . 10_1101-2021_01_04_425177 87 1 It -PRON- PRP 10_1101-2021_01_04_425177 87 2 is be VBZ 10_1101-2021_01_04_425177 87 3 The the DT 10_1101-2021_01_04_425177 87 4 copyright copyright NN 10_1101-2021_01_04_425177 87 5 holder holder NN 10_1101-2021_01_04_425177 87 6 for for IN 10_1101-2021_01_04_425177 87 7 this this DT 10_1101-2021_01_04_425177 87 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 87 9 version version NN 10_1101-2021_01_04_425177 87 10 posted post VBD 10_1101-2021_01_04_425177 87 11 January January NNP 10_1101-2021_01_04_425177 87 12 4 4 CD 10_1101-2021_01_04_425177 87 13 , , , 10_1101-2021_01_04_425177 87 14 2021 2021 CD 10_1101-2021_01_04_425177 87 15 . . . 10_1101-2021_01_04_425177 87 16 ; ; : 10_1101-2021_01_04_425177 87 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 87 18 : : : 10_1101-2021_01_04_425177 87 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 87 20 preprint preprint NN 10_1101-2021_01_04_425177 87 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 NNP 10_1101-2021_01_04_425177 87 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ NN 10_1101-2021_01_04_425177 87 23 8 8 CD 10_1101-2021_01_04_425177 87 24 Interestingly interestingly RB 10_1101-2021_01_04_425177 87 25 , , , 10_1101-2021_01_04_425177 87 26 the the DT 10_1101-2021_01_04_425177 87 27 sample sample NN 10_1101-2021_01_04_425177 87 28 containing contain VBG 10_1101-2021_01_04_425177 87 29 both both CC 10_1101-2021_01_04_425177 87 30 0.5 0.5 CD 10_1101-2021_01_04_425177 87 31 µM µM NNP 10_1101-2021_01_04_425177 87 32 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 87 33 and and CC 10_1101-2021_01_04_425177 87 34 0.5 0.5 CD 10_1101-2021_01_04_425177 87 35 µM µM NNP 10_1101-2021_01_04_425177 87 36 huPrP huprp NN 10_1101-2021_01_04_425177 87 37 displays display VBZ 10_1101-2021_01_04_425177 87 38 no no DT 10_1101-2021_01_04_425177 87 39 fibrils fibril NNS 10_1101-2021_01_04_425177 87 40 , , , 10_1101-2021_01_04_425177 87 41 but but CC 10_1101-2021_01_04_425177 87 42 only only RB 10_1101-2021_01_04_425177 87 43 numerous numerous JJ 10_1101-2021_01_04_425177 87 44 small small JJ 10_1101-2021_01_04_425177 87 45 aggregate aggregate NN 10_1101-2021_01_04_425177 87 46 clumps clump NNS 10_1101-2021_01_04_425177 87 47 , , , 10_1101-2021_01_04_425177 87 48 about about RB 10_1101-2021_01_04_425177 87 49 2 2 CD 10_1101-2021_01_04_425177 87 50 nm nm CC 10_1101-2021_01_04_425177 87 51 high high JJ 10_1101-2021_01_04_425177 87 52 ( ( -LRB- 10_1101-2021_01_04_425177 87 53 Fig fig NN 10_1101-2021_01_04_425177 87 54 . . . 10_1101-2021_01_04_425177 88 1 1D 1D NNP 10_1101-2021_01_04_425177 88 2 ) ) -RRB- 10_1101-2021_01_04_425177 88 3 . . . 10_1101-2021_01_04_425177 89 1 Even even RB 10_1101-2021_01_04_425177 89 2 after after IN 10_1101-2021_01_04_425177 89 3 72 72 CD 10_1101-2021_01_04_425177 89 4 hours hour NNS 10_1101-2021_01_04_425177 89 5 no no DT 10_1101-2021_01_04_425177 89 6 fibrils fibril NNS 10_1101-2021_01_04_425177 89 7 can can MD 10_1101-2021_01_04_425177 89 8 be be VB 10_1101-2021_01_04_425177 89 9 seen see VBN 10_1101-2021_01_04_425177 89 10 , , , 10_1101-2021_01_04_425177 89 11 but but CC 10_1101-2021_01_04_425177 89 12 the the DT 10_1101-2021_01_04_425177 89 13 aggregate aggregate JJ 10_1101-2021_01_04_425177 89 14 clumps clump NNS 10_1101-2021_01_04_425177 89 15 are be VBP 10_1101-2021_01_04_425177 89 16 then then RB 10_1101-2021_01_04_425177 89 17 fewer few JJR 10_1101-2021_01_04_425177 89 18 and and CC 10_1101-2021_01_04_425177 89 19 larger large JJR 10_1101-2021_01_04_425177 89 20 , , , 10_1101-2021_01_04_425177 89 21 around around RB 10_1101-2021_01_04_425177 89 22 3 3 CD 10_1101-2021_01_04_425177 89 23 – – SYM 10_1101-2021_01_04_425177 89 24 4 4 CD 10_1101-2021_01_04_425177 89 25 nm nm CC 10_1101-2021_01_04_425177 89 26 high high JJ 10_1101-2021_01_04_425177 89 27 ( ( -LRB- 10_1101-2021_01_04_425177 89 28 Fig fig NN 10_1101-2021_01_04_425177 89 29 1E 1E NNP 10_1101-2021_01_04_425177 89 30 ) ) -RRB- 10_1101-2021_01_04_425177 89 31 . . . 10_1101-2021_01_04_425177 90 1 As as IN 10_1101-2021_01_04_425177 90 2 it -PRON- PRP 10_1101-2021_01_04_425177 90 3 can can MD 10_1101-2021_01_04_425177 90 4 not not RB 10_1101-2021_01_04_425177 90 5 be be VB 10_1101-2021_01_04_425177 90 6 ruled rule VBN 10_1101-2021_01_04_425177 90 7 out out RP 10_1101-2021_01_04_425177 90 8 that that IN 10_1101-2021_01_04_425177 90 9 these these DT 10_1101-2021_01_04_425177 90 10 small small JJ 10_1101-2021_01_04_425177 90 11 aggregate aggregate NN 10_1101-2021_01_04_425177 90 12 clumps clump NNS 10_1101-2021_01_04_425177 90 13 will will MD 10_1101-2021_01_04_425177 90 14 eventually eventually RB 10_1101-2021_01_04_425177 90 15 form form VB 10_1101-2021_01_04_425177 90 16 fibrils fibril NNS 10_1101-2021_01_04_425177 90 17 , , , 10_1101-2021_01_04_425177 90 18 it -PRON- PRP 10_1101-2021_01_04_425177 90 19 is be VBZ 10_1101-2021_01_04_425177 90 20 not not RB 10_1101-2021_01_04_425177 90 21 possible possible JJ 10_1101-2021_01_04_425177 90 22 to to TO 10_1101-2021_01_04_425177 90 23 tell tell VB 10_1101-2021_01_04_425177 90 24 if if IN 10_1101-2021_01_04_425177 90 25 fibrillation fibrillation NN 10_1101-2021_01_04_425177 90 26 is be VBZ 10_1101-2021_01_04_425177 90 27 completely completely RB 10_1101-2021_01_04_425177 90 28 inhibited inhibit VBN 10_1101-2021_01_04_425177 90 29 , , , 10_1101-2021_01_04_425177 90 30 or or CC 10_1101-2021_01_04_425177 90 31 if if IN 10_1101-2021_01_04_425177 90 32 the the DT 10_1101-2021_01_04_425177 90 33 fibrillation fibrillation NN 10_1101-2021_01_04_425177 90 34 rate rate NN 10_1101-2021_01_04_425177 90 35 merely merely RB 10_1101-2021_01_04_425177 90 36 is be VBZ 10_1101-2021_01_04_425177 90 37 significantly significantly RB 10_1101-2021_01_04_425177 90 38 reduced reduce VBN 10_1101-2021_01_04_425177 90 39 . . . 10_1101-2021_01_04_425177 91 1 Nonetheless nonetheless RB 10_1101-2021_01_04_425177 91 2 , , , 10_1101-2021_01_04_425177 91 3 the the DT 10_1101-2021_01_04_425177 91 4 absence absence NN 10_1101-2021_01_04_425177 91 5 of of IN 10_1101-2021_01_04_425177 91 6 fibrillar fibrillar JJ 10_1101-2021_01_04_425177 91 7 aggregates aggregate NNS 10_1101-2021_01_04_425177 91 8 of of IN 10_1101-2021_01_04_425177 91 9 huPrP huprp NN 10_1101-2021_01_04_425177 91 10 in in IN 10_1101-2021_01_04_425177 91 11 the the DT 10_1101-2021_01_04_425177 91 12 presence presence NN 10_1101-2021_01_04_425177 91 13 of of IN 10_1101-2021_01_04_425177 91 14 equimolar equimolar JJ 10_1101-2021_01_04_425177 91 15 concentrations concentration NNS 10_1101-2021_01_04_425177 91 16 of of IN 10_1101-2021_01_04_425177 91 17 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 91 18 clearly clearly RB 10_1101-2021_01_04_425177 91 19 shows show VBZ 10_1101-2021_01_04_425177 91 20 that that IN 10_1101-2021_01_04_425177 91 21 the the DT 10_1101-2021_01_04_425177 91 22 peptide peptide NN 10_1101-2021_01_04_425177 91 23 construct construct VBP 10_1101-2021_01_04_425177 91 24 directly directly RB 10_1101-2021_01_04_425177 91 25 interacts interact VBZ 10_1101-2021_01_04_425177 91 26 with with IN 10_1101-2021_01_04_425177 91 27 the the DT 10_1101-2021_01_04_425177 91 28 huPrP huprp JJ 10_1101-2021_01_04_425177 91 29 protein protein NN 10_1101-2021_01_04_425177 91 30 and and CC 10_1101-2021_01_04_425177 91 31 interferes interfere VBZ 10_1101-2021_01_04_425177 91 32 with with IN 10_1101-2021_01_04_425177 91 33 its -PRON- PRP$ 10_1101-2021_01_04_425177 91 34 aggregation aggregation NN 10_1101-2021_01_04_425177 91 35 . . . 10_1101-2021_01_04_425177 92 1 As as IN 10_1101-2021_01_04_425177 92 2 both both DT 10_1101-2021_01_04_425177 92 3 molecules molecule NNS 10_1101-2021_01_04_425177 92 4 are be VBP 10_1101-2021_01_04_425177 92 5 positively positively RB 10_1101-2021_01_04_425177 92 6 charged charge VBN 10_1101-2021_01_04_425177 92 7 ( ( -LRB- 10_1101-2021_01_04_425177 92 8 Table table NN 10_1101-2021_01_04_425177 92 9 1 1 CD 10_1101-2021_01_04_425177 92 10 ) ) -RRB- 10_1101-2021_01_04_425177 92 11 , , , 10_1101-2021_01_04_425177 92 12 it -PRON- PRP 10_1101-2021_01_04_425177 92 13 stands stand VBZ 10_1101-2021_01_04_425177 92 14 to to TO 10_1101-2021_01_04_425177 92 15 reason reason NN 10_1101-2021_01_04_425177 92 16 that that IN 10_1101-2021_01_04_425177 92 17 they -PRON- PRP 10_1101-2021_01_04_425177 92 18 interact interact VBP 10_1101-2021_01_04_425177 92 19 mainly mainly RB 10_1101-2021_01_04_425177 92 20 via via IN 10_1101-2021_01_04_425177 92 21 hydrophobic hydrophobic JJ 10_1101-2021_01_04_425177 92 22 forces force NNS 10_1101-2021_01_04_425177 92 23 . . . 10_1101-2021_01_04_425177 93 1 The the DT 10_1101-2021_01_04_425177 93 2 aggregation aggregation NN 10_1101-2021_01_04_425177 93 3 - - HYPH 10_1101-2021_01_04_425177 93 4 inhibiting inhibit VBG 10_1101-2021_01_04_425177 93 5 effect effect NN 10_1101-2021_01_04_425177 93 6 of of IN 10_1101-2021_01_04_425177 93 7 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 93 8 ( ( -LRB- 10_1101-2021_01_04_425177 93 9 Fig fig NN 10_1101-2021_01_04_425177 93 10 . . . 10_1101-2021_01_04_425177 94 1 1 1 LS 10_1101-2021_01_04_425177 94 2 ) ) -RRB- 10_1101-2021_01_04_425177 94 3 appears appear VBZ 10_1101-2021_01_04_425177 94 4 to to TO 10_1101-2021_01_04_425177 94 5 provide provide VB 10_1101-2021_01_04_425177 94 6 an an DT 10_1101-2021_01_04_425177 94 7 explanation explanation NN 10_1101-2021_01_04_425177 94 8 , , , 10_1101-2021_01_04_425177 94 9 at at IN 10_1101-2021_01_04_425177 94 10 a a DT 10_1101-2021_01_04_425177 94 11 molecular molecular JJ 10_1101-2021_01_04_425177 94 12 level level NN 10_1101-2021_01_04_425177 94 13 , , , 10_1101-2021_01_04_425177 94 14 to to IN 10_1101-2021_01_04_425177 94 15 our -PRON- PRP$ 10_1101-2021_01_04_425177 94 16 earlier early JJR 10_1101-2021_01_04_425177 94 17 observations observation NNS 10_1101-2021_01_04_425177 94 18 that that IN 10_1101-2021_01_04_425177 94 19 such such JJ 10_1101-2021_01_04_425177 94 20 peptide peptide NN 10_1101-2021_01_04_425177 94 21 constructs construct NNS 10_1101-2021_01_04_425177 94 22 significantly significantly RB 10_1101-2021_01_04_425177 94 23 reduce reduce VBP 10_1101-2021_01_04_425177 94 24 the the DT 10_1101-2021_01_04_425177 94 25 levels level NNS 10_1101-2021_01_04_425177 94 26 of of IN 10_1101-2021_01_04_425177 94 27 prion prion NN 10_1101-2021_01_04_425177 94 28 aggregates aggregate NNS 10_1101-2021_01_04_425177 94 29 in in IN 10_1101-2021_01_04_425177 94 30 prion prion NN 10_1101-2021_01_04_425177 94 31 - - HYPH 10_1101-2021_01_04_425177 94 32 infected infect VBN 10_1101-2021_01_04_425177 94 33 cells cell NNS 10_1101-2021_01_04_425177 94 34 ( ( -LRB- 10_1101-2021_01_04_425177 94 35 Löfgren Löfgren NNP 10_1101-2021_01_04_425177 94 36 et et NNP 10_1101-2021_01_04_425177 94 37 al al NNP 10_1101-2021_01_04_425177 94 38 . . NNP 10_1101-2021_01_04_425177 94 39 , , , 10_1101-2021_01_04_425177 94 40 2008 2008 CD 10_1101-2021_01_04_425177 94 41 ; ; : 10_1101-2021_01_04_425177 94 42 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 94 43 et et NNP 10_1101-2021_01_04_425177 94 44 al al NNP 10_1101-2021_01_04_425177 94 45 . . NNP 10_1101-2021_01_04_425177 94 46 , , , 10_1101-2021_01_04_425177 94 47 2014 2014 CD 10_1101-2021_01_04_425177 94 48 ) ) -RRB- 10_1101-2021_01_04_425177 94 49 . . . 10_1101-2021_01_04_425177 95 1 As as IN 10_1101-2021_01_04_425177 95 2 both both DT 10_1101-2021_01_04_425177 95 3 the the DT 10_1101-2021_01_04_425177 95 4 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 95 5 peptide peptide NN 10_1101-2021_01_04_425177 95 6 and and CC 10_1101-2021_01_04_425177 95 7 the the DT 10_1101-2021_01_04_425177 95 8 huPrP huprp NN 10_1101-2021_01_04_425177 95 9 protein protein NN 10_1101-2021_01_04_425177 95 10 can can MD 10_1101-2021_01_04_425177 95 11 form form VB 10_1101-2021_01_04_425177 95 12 amyloid amyloid NN 10_1101-2021_01_04_425177 95 13 fibrils fibril NNS 10_1101-2021_01_04_425177 95 14 by by IN 10_1101-2021_01_04_425177 95 15 themselves -PRON- PRP 10_1101-2021_01_04_425177 95 16 ( ( -LRB- 10_1101-2021_01_04_425177 95 17 Figs fig NNS 10_1101-2021_01_04_425177 95 18 . . . 10_1101-2021_01_04_425177 96 1 1A 1A NNP 10_1101-2021_01_04_425177 96 2 and and CC 10_1101-2021_01_04_425177 96 3 1C 1C NNP 10_1101-2021_01_04_425177 96 4 ) ) -RRB- 10_1101-2021_01_04_425177 96 5 , , , 10_1101-2021_01_04_425177 96 6 the the DT 10_1101-2021_01_04_425177 96 7 two two CD 10_1101-2021_01_04_425177 96 8 molecules molecule NNS 10_1101-2021_01_04_425177 96 9 may may MD 10_1101-2021_01_04_425177 96 10 interact interact VB 10_1101-2021_01_04_425177 96 11 via via IN 10_1101-2021_01_04_425177 96 12 cross cross NN 10_1101-2021_01_04_425177 96 13 - - NN 10_1101-2021_01_04_425177 96 14 aggregation aggregation NN 10_1101-2021_01_04_425177 96 15 , , , 10_1101-2021_01_04_425177 96 16 to to TO 10_1101-2021_01_04_425177 96 17 form form VB 10_1101-2021_01_04_425177 96 18 smaller small JJR 10_1101-2021_01_04_425177 96 19 non non JJ 10_1101-2021_01_04_425177 96 20 - - JJ 10_1101-2021_01_04_425177 96 21 fibrillar fibrillar JJ 10_1101-2021_01_04_425177 96 22 co- co- JJ 10_1101-2021_01_04_425177 96 23 aggregates aggregate NNS 10_1101-2021_01_04_425177 96 24 ( ( -LRB- 10_1101-2021_01_04_425177 96 25 Fig fig NN 10_1101-2021_01_04_425177 96 26 . . . 10_1101-2021_01_04_425177 97 1 1E 1E NNP 10_1101-2021_01_04_425177 97 2 ) ) -RRB- 10_1101-2021_01_04_425177 97 3 that that WDT 10_1101-2021_01_04_425177 97 4 could could MD 10_1101-2021_01_04_425177 97 5 be be VB 10_1101-2021_01_04_425177 97 6 less less RBR 10_1101-2021_01_04_425177 97 7 toxic toxic JJ 10_1101-2021_01_04_425177 97 8 than than IN 10_1101-2021_01_04_425177 97 9 pure pure JJ 10_1101-2021_01_04_425177 97 10 huPrP huprp NN 10_1101-2021_01_04_425177 97 11 aggregates aggregate NNS 10_1101-2021_01_04_425177 97 12 ( ( -LRB- 10_1101-2021_01_04_425177 97 13 Luo Luo NNP 10_1101-2021_01_04_425177 97 14 et et NNP 10_1101-2021_01_04_425177 97 15 al al NNP 10_1101-2021_01_04_425177 97 16 . . NNP 10_1101-2021_01_04_425177 97 17 , , , 10_1101-2021_01_04_425177 97 18 2016 2016 CD 10_1101-2021_01_04_425177 97 19 , , , 10_1101-2021_01_04_425177 97 20 2017 2017 CD 10_1101-2021_01_04_425177 97 21 ) ) -RRB- 10_1101-2021_01_04_425177 97 22 . . . 10_1101-2021_01_04_425177 98 1 If if IN 10_1101-2021_01_04_425177 98 2 so so RB 10_1101-2021_01_04_425177 98 3 , , , 10_1101-2021_01_04_425177 98 4 the the DT 10_1101-2021_01_04_425177 98 5 huPrP huprp NN 10_1101-2021_01_04_425177 98 6 / / SYM 10_1101-2021_01_04_425177 98 7 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 98 8 interactions interaction NNS 10_1101-2021_01_04_425177 98 9 would would MD 10_1101-2021_01_04_425177 98 10 be be VB 10_1101-2021_01_04_425177 98 11 similar similar JJ 10_1101-2021_01_04_425177 98 12 to to IN 10_1101-2021_01_04_425177 98 13 the the DT 10_1101-2021_01_04_425177 98 14 interactions interaction NNS 10_1101-2021_01_04_425177 98 15 between between IN 10_1101-2021_01_04_425177 98 16 Aβ Aβ NNP 10_1101-2021_01_04_425177 98 17 and and CC 10_1101-2021_01_04_425177 98 18 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 98 19 ( ( -LRB- 10_1101-2021_01_04_425177 98 20 Henning Henning NNP 10_1101-2021_01_04_425177 98 21 - - HYPH 10_1101-2021_01_04_425177 98 22 Knechtel Knechtel NNP 10_1101-2021_01_04_425177 98 23 et et FW 10_1101-2021_01_04_425177 98 24 al al NNP 10_1101-2021_01_04_425177 98 25 . . NNP 10_1101-2021_01_04_425177 98 26 , , , 10_1101-2021_01_04_425177 98 27 2020 2020 CD 10_1101-2021_01_04_425177 98 28 ) ) -RRB- 10_1101-2021_01_04_425177 98 29 . . . 10_1101-2021_01_04_425177 99 1 In in IN 10_1101-2021_01_04_425177 99 2 any any DT 10_1101-2021_01_04_425177 99 3 case case NN 10_1101-2021_01_04_425177 99 4 , , , 10_1101-2021_01_04_425177 99 5 the the DT 10_1101-2021_01_04_425177 99 6 huPrP huprp NN 10_1101-2021_01_04_425177 99 7 / / SYM 10_1101-2021_01_04_425177 99 8 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 99 9 interactions interaction NNS 10_1101-2021_01_04_425177 99 10 are be VBP 10_1101-2021_01_04_425177 99 11 very very RB 10_1101-2021_01_04_425177 99 12 different different JJ 10_1101-2021_01_04_425177 99 13 from from IN 10_1101-2021_01_04_425177 99 14 the the DT 10_1101-2021_01_04_425177 99 15 interactions interaction NNS 10_1101-2021_01_04_425177 99 16 between between IN 10_1101-2021_01_04_425177 99 17 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 99 18 and and CC 10_1101-2021_01_04_425177 99 19 S100A9 s100a9 VB 10_1101-2021_01_04_425177 99 20 protein protein NN 10_1101-2021_01_04_425177 99 21 , , , 10_1101-2021_01_04_425177 99 22 where where WRB 10_1101-2021_01_04_425177 99 23 amyloid amyloid NNP 10_1101-2021_01_04_425177 99 24 aggregation aggregation NN 10_1101-2021_01_04_425177 99 25 is be VBZ 10_1101-2021_01_04_425177 99 26 promoted promote VBN 10_1101-2021_01_04_425177 99 27 ( ( -LRB- 10_1101-2021_01_04_425177 99 28 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 99 29 et et FW 10_1101-2021_01_04_425177 99 30 al al NNP 10_1101-2021_01_04_425177 99 31 . . NNP 10_1101-2021_01_04_425177 99 32 , , , 10_1101-2021_01_04_425177 99 33 2019 2019 CD 10_1101-2021_01_04_425177 99 34 ) ) -RRB- 10_1101-2021_01_04_425177 99 35 . . . 10_1101-2021_01_04_425177 100 1 Because because IN 10_1101-2021_01_04_425177 100 2 the the DT 10_1101-2021_01_04_425177 100 3 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 100 4 construct construct NN 10_1101-2021_01_04_425177 100 5 has have VBZ 10_1101-2021_01_04_425177 100 6 different different JJ 10_1101-2021_01_04_425177 100 7 effects effect NNS 10_1101-2021_01_04_425177 100 8 on on IN 10_1101-2021_01_04_425177 100 9 different different JJ 10_1101-2021_01_04_425177 100 10 aggregating aggregate VBG 10_1101-2021_01_04_425177 100 11 proteins protein NNS 10_1101-2021_01_04_425177 100 12 , , , 10_1101-2021_01_04_425177 100 13 it -PRON- PRP 10_1101-2021_01_04_425177 100 14 would would MD 10_1101-2021_01_04_425177 100 15 be be VB 10_1101-2021_01_04_425177 100 16 interesting interesting JJ 10_1101-2021_01_04_425177 100 17 to to TO 10_1101-2021_01_04_425177 100 18 study study VB 10_1101-2021_01_04_425177 100 19 how how WRB 10_1101-2021_01_04_425177 100 20 this this DT 10_1101-2021_01_04_425177 100 21 construct construct NN 10_1101-2021_01_04_425177 100 22 might may MD 10_1101-2021_01_04_425177 100 23 affect affect VB 10_1101-2021_01_04_425177 100 24 the the DT 10_1101-2021_01_04_425177 100 25 aggregation aggregation NN 10_1101-2021_01_04_425177 100 26 of of IN 10_1101-2021_01_04_425177 100 27 other other JJ 10_1101-2021_01_04_425177 100 28 disease disease NN 10_1101-2021_01_04_425177 100 29 - - HYPH 10_1101-2021_01_04_425177 100 30 related relate VBN 10_1101-2021_01_04_425177 100 31 prion prion NN 10_1101-2021_01_04_425177 100 32 proteins protein NNS 10_1101-2021_01_04_425177 100 33 , , , 10_1101-2021_01_04_425177 100 34 such such JJ 10_1101-2021_01_04_425177 100 35 as as IN 10_1101-2021_01_04_425177 100 36 those those DT 10_1101-2021_01_04_425177 100 37 involved involve VBN 10_1101-2021_01_04_425177 100 38 in in IN 10_1101-2021_01_04_425177 100 39 animal animal NN 10_1101-2021_01_04_425177 100 40 diseases disease NNS 10_1101-2021_01_04_425177 100 41 like like IN 10_1101-2021_01_04_425177 100 42 bovine bovine JJ 10_1101-2021_01_04_425177 100 43 spongiform spongiform NN 10_1101-2021_01_04_425177 100 44 encephalopathy encephalopathy NNP 10_1101-2021_01_04_425177 100 45 ( ( -LRB- 10_1101-2021_01_04_425177 100 46 BSE BSE NNP 10_1101-2021_01_04_425177 100 47 ) ) -RRB- 10_1101-2021_01_04_425177 100 48 , , , 10_1101-2021_01_04_425177 100 49 chronic chronic JJ 10_1101-2021_01_04_425177 100 50 wasting waste VBG 10_1101-2021_01_04_425177 100 51 disease disease NN 10_1101-2021_01_04_425177 100 52 in in IN 10_1101-2021_01_04_425177 100 53 cervids cervid NNS 10_1101-2021_01_04_425177 100 54 , , , 10_1101-2021_01_04_425177 100 55 and and CC 10_1101-2021_01_04_425177 100 56 sheep sheep NN 10_1101-2021_01_04_425177 100 57 scrapie scrapie NN 10_1101-2021_01_04_425177 100 58 ( ( -LRB- 10_1101-2021_01_04_425177 100 59 Vazquez Vazquez NNP 10_1101-2021_01_04_425177 100 60 - - HYPH 10_1101-2021_01_04_425177 100 61 Fernandez Fernandez NNP 10_1101-2021_01_04_425177 100 62 et et FW 10_1101-2021_01_04_425177 100 63 al al NNP 10_1101-2021_01_04_425177 100 64 . . NNP 10_1101-2021_01_04_425177 100 65 , , , 10_1101-2021_01_04_425177 100 66 2017 2017 CD 10_1101-2021_01_04_425177 100 67 ) ) -RRB- 10_1101-2021_01_04_425177 100 68 . . . 10_1101-2021_01_04_425177 101 1 .CC .CC NFP 10_1101-2021_01_04_425177 101 2 - - : 10_1101-2021_01_04_425177 101 3 BY by IN 10_1101-2021_01_04_425177 101 4 - - HYPH 10_1101-2021_01_04_425177 101 5 NC NC NNP 10_1101-2021_01_04_425177 101 6 - - HYPH 10_1101-2021_01_04_425177 101 7 ND ND NNP 10_1101-2021_01_04_425177 101 8 4.0 4.0 CD 10_1101-2021_01_04_425177 101 9 International international JJ 10_1101-2021_01_04_425177 101 10 licensemade licensemade NN 10_1101-2021_01_04_425177 101 11 available available JJ 10_1101-2021_01_04_425177 101 12 under under IN 10_1101-2021_01_04_425177 101 13 a a DT 10_1101-2021_01_04_425177 101 14 ( ( -LRB- 10_1101-2021_01_04_425177 101 15 which which WDT 10_1101-2021_01_04_425177 101 16 was be VBD 10_1101-2021_01_04_425177 101 17 not not RB 10_1101-2021_01_04_425177 101 18 certified certify VBN 10_1101-2021_01_04_425177 101 19 by by IN 10_1101-2021_01_04_425177 101 20 peer peer NN 10_1101-2021_01_04_425177 101 21 review review NN 10_1101-2021_01_04_425177 101 22 ) ) -RRB- 10_1101-2021_01_04_425177 101 23 is be VBZ 10_1101-2021_01_04_425177 101 24 the the DT 10_1101-2021_01_04_425177 101 25 author author NN 10_1101-2021_01_04_425177 101 26 / / SYM 10_1101-2021_01_04_425177 101 27 funder funder NN 10_1101-2021_01_04_425177 101 28 , , , 10_1101-2021_01_04_425177 101 29 who who WP 10_1101-2021_01_04_425177 101 30 has have VBZ 10_1101-2021_01_04_425177 101 31 granted grant VBN 10_1101-2021_01_04_425177 101 32 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 101 33 a a DT 10_1101-2021_01_04_425177 101 34 license license NN 10_1101-2021_01_04_425177 101 35 to to TO 10_1101-2021_01_04_425177 101 36 display display VB 10_1101-2021_01_04_425177 101 37 the the DT 10_1101-2021_01_04_425177 101 38 preprint preprint NN 10_1101-2021_01_04_425177 101 39 in in IN 10_1101-2021_01_04_425177 101 40 perpetuity perpetuity NN 10_1101-2021_01_04_425177 101 41 . . . 10_1101-2021_01_04_425177 102 1 It -PRON- PRP 10_1101-2021_01_04_425177 102 2 is be VBZ 10_1101-2021_01_04_425177 102 3 The the DT 10_1101-2021_01_04_425177 102 4 copyright copyright NN 10_1101-2021_01_04_425177 102 5 holder holder NN 10_1101-2021_01_04_425177 102 6 for for IN 10_1101-2021_01_04_425177 102 7 this this DT 10_1101-2021_01_04_425177 102 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 102 9 version version NN 10_1101-2021_01_04_425177 102 10 posted post VBD 10_1101-2021_01_04_425177 102 11 January January NNP 10_1101-2021_01_04_425177 102 12 4 4 CD 10_1101-2021_01_04_425177 102 13 , , , 10_1101-2021_01_04_425177 102 14 2021 2021 CD 10_1101-2021_01_04_425177 102 15 . . . 10_1101-2021_01_04_425177 102 16 ; ; : 10_1101-2021_01_04_425177 102 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 102 18 : : : 10_1101-2021_01_04_425177 102 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 102 20 preprint preprint NN 10_1101-2021_01_04_425177 102 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 VBZ 10_1101-2021_01_04_425177 102 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_04_425177 102 23 9 9 CD 10_1101-2021_01_04_425177 102 24 4 4 CD 10_1101-2021_01_04_425177 102 25 . . . 10_1101-2021_01_04_425177 103 1 Conclusions conclusion NNS 10_1101-2021_01_04_425177 103 2 Our -PRON- PRP$ 10_1101-2021_01_04_425177 103 3 atomic atomic JJ 10_1101-2021_01_04_425177 103 4 force force NN 10_1101-2021_01_04_425177 103 5 microscopy microscopy JJ 10_1101-2021_01_04_425177 103 6 images image NNS 10_1101-2021_01_04_425177 103 7 show show VBP 10_1101-2021_01_04_425177 103 8 that that IN 10_1101-2021_01_04_425177 103 9 the the DT 10_1101-2021_01_04_425177 103 10 in in FW 10_1101-2021_01_04_425177 103 11 vitro vitro FW 10_1101-2021_01_04_425177 103 12 aggregation aggregation NN 10_1101-2021_01_04_425177 103 13 of of IN 10_1101-2021_01_04_425177 103 14 the the DT 10_1101-2021_01_04_425177 103 15 human human JJ 10_1101-2021_01_04_425177 103 16 PrP PrP NNP 10_1101-2021_01_04_425177 103 17 protein protein NN 10_1101-2021_01_04_425177 103 18 is be VBZ 10_1101-2021_01_04_425177 103 19 inhibited inhibit VBN 10_1101-2021_01_04_425177 103 20 by by IN 10_1101-2021_01_04_425177 103 21 equimolar equimolar JJ 10_1101-2021_01_04_425177 103 22 amounts amount NNS 10_1101-2021_01_04_425177 103 23 of of IN 10_1101-2021_01_04_425177 103 24 the the DT 10_1101-2021_01_04_425177 103 25 25 25 CD 10_1101-2021_01_04_425177 103 26 residues residue NNS 10_1101-2021_01_04_425177 103 27 long long RB 10_1101-2021_01_04_425177 103 28 engineered engineer VBN 10_1101-2021_01_04_425177 103 29 peptide peptide NN 10_1101-2021_01_04_425177 103 30 NCAM1-Aβ NCAM1-Aβ NNP 10_1101-2021_01_04_425177 103 31 . . . 10_1101-2021_01_04_425177 104 1 Thus thus RB 10_1101-2021_01_04_425177 104 2 , , , 10_1101-2021_01_04_425177 104 3 a a DT 10_1101-2021_01_04_425177 104 4 very very RB 10_1101-2021_01_04_425177 104 5 likely likely JJ 10_1101-2021_01_04_425177 104 6 molecular molecular JJ 10_1101-2021_01_04_425177 104 7 - - HYPH 10_1101-2021_01_04_425177 104 8 level level NN 10_1101-2021_01_04_425177 104 9 explanation explanation NN 10_1101-2021_01_04_425177 104 10 to to IN 10_1101-2021_01_04_425177 104 11 our -PRON- PRP$ 10_1101-2021_01_04_425177 104 12 previous previous JJ 10_1101-2021_01_04_425177 104 13 observation observation NN 10_1101-2021_01_04_425177 104 14 that that IN 10_1101-2021_01_04_425177 104 15 such such JJ 10_1101-2021_01_04_425177 104 16 cell cell NN 10_1101-2021_01_04_425177 104 17 - - HYPH 10_1101-2021_01_04_425177 104 18 penetrating penetrate VBG 10_1101-2021_01_04_425177 104 19 peptide peptide NN 10_1101-2021_01_04_425177 104 20 constructs construct NNS 10_1101-2021_01_04_425177 104 21 can can MD 10_1101-2021_01_04_425177 104 22 reduce reduce VB 10_1101-2021_01_04_425177 104 23 the the DT 10_1101-2021_01_04_425177 104 24 amount amount NN 10_1101-2021_01_04_425177 104 25 of of IN 10_1101-2021_01_04_425177 104 26 prion prion NN 10_1101-2021_01_04_425177 104 27 aggregates aggregate NNS 10_1101-2021_01_04_425177 104 28 in in IN 10_1101-2021_01_04_425177 104 29 infected infected JJ 10_1101-2021_01_04_425177 104 30 cells cell NNS 10_1101-2021_01_04_425177 104 31 , , , 10_1101-2021_01_04_425177 104 32 is be VBZ 10_1101-2021_01_04_425177 104 33 that that IN 10_1101-2021_01_04_425177 104 34 these these DT 10_1101-2021_01_04_425177 104 35 peptide peptide JJ 10_1101-2021_01_04_425177 104 36 constructs construct NNS 10_1101-2021_01_04_425177 104 37 directly directly RB 10_1101-2021_01_04_425177 104 38 interact interact VBP 10_1101-2021_01_04_425177 104 39 with with IN 10_1101-2021_01_04_425177 104 40 the the DT 10_1101-2021_01_04_425177 104 41 PrP PrP NNP 10_1101-2021_01_04_425177 104 42 protein protein NN 10_1101-2021_01_04_425177 104 43 and and CC 10_1101-2021_01_04_425177 104 44 prevent prevent VB 10_1101-2021_01_04_425177 104 45 its -PRON- PRP$ 10_1101-2021_01_04_425177 104 46 fibrillation fibrillation NN 10_1101-2021_01_04_425177 104 47 . . . 10_1101-2021_01_04_425177 105 1 Funding funding NN 10_1101-2021_01_04_425177 105 2 : : : 10_1101-2021_01_04_425177 105 3 The the DT 10_1101-2021_01_04_425177 105 4 research research NN 10_1101-2021_01_04_425177 105 5 of of IN 10_1101-2021_01_04_425177 105 6 MG MG NNP 10_1101-2021_01_04_425177 105 7 , , , 10_1101-2021_01_04_425177 105 8 IZ IZ NNP 10_1101-2021_01_04_425177 105 9 , , , 10_1101-2021_01_04_425177 105 10 LZ LZ NNP 10_1101-2021_01_04_425177 105 11 and and CC 10_1101-2021_01_04_425177 105 12 MK MK NNP 10_1101-2021_01_04_425177 105 13 was be VBD 10_1101-2021_01_04_425177 105 14 supported support VBN 10_1101-2021_01_04_425177 105 15 by by IN 10_1101-2021_01_04_425177 105 16 an an DT 10_1101-2021_01_04_425177 105 17 OPUS OPUS NNP 10_1101-2021_01_04_425177 105 18 research research NN 10_1101-2021_01_04_425177 105 19 grant grant NN 10_1101-2021_01_04_425177 105 20 ( ( -LRB- 10_1101-2021_01_04_425177 105 21 2014/15 2014/15 CD 10_1101-2021_01_04_425177 105 22 / / SYM 10_1101-2021_01_04_425177 105 23 B B NNP 10_1101-2021_01_04_425177 105 24 / / SYM 10_1101-2021_01_04_425177 105 25 ST4/04839 st4/04839 NN 10_1101-2021_01_04_425177 105 26 ) ) -RRB- 10_1101-2021_01_04_425177 105 27 from from IN 10_1101-2021_01_04_425177 105 28 the the DT 10_1101-2021_01_04_425177 105 29 National National NNP 10_1101-2021_01_04_425177 105 30 Science Science NNP 10_1101-2021_01_04_425177 105 31 Centre Centre NNP 10_1101-2021_01_04_425177 105 32 ( ( -LRB- 10_1101-2021_01_04_425177 105 33 Poland Poland NNP 10_1101-2021_01_04_425177 105 34 ) ) -RRB- 10_1101-2021_01_04_425177 105 35 . . . 10_1101-2021_01_04_425177 106 1 AG AG NNP 10_1101-2021_01_04_425177 106 2 was be VBD 10_1101-2021_01_04_425177 106 3 supported support VBN 10_1101-2021_01_04_425177 106 4 by by IN 10_1101-2021_01_04_425177 106 5 grants grant NNS 10_1101-2021_01_04_425177 106 6 from from IN 10_1101-2021_01_04_425177 106 7 the the DT 10_1101-2021_01_04_425177 106 8 Swedish Swedish NNP 10_1101-2021_01_04_425177 106 9 Research Research NNP 10_1101-2021_01_04_425177 106 10 Council Council NNP 10_1101-2021_01_04_425177 106 11 and and CC 10_1101-2021_01_04_425177 106 12 from from IN 10_1101-2021_01_04_425177 106 13 Byggmästare Byggmästare NNP 10_1101-2021_01_04_425177 106 14 Engkvist´s Engkvist´s NNP 10_1101-2021_01_04_425177 106 15 Foundation Foundation NNP 10_1101-2021_01_04_425177 106 16 . . . 10_1101-2021_01_04_425177 107 1 Conflicts conflict NNS 10_1101-2021_01_04_425177 107 2 of of IN 10_1101-2021_01_04_425177 107 3 Interest interest NN 10_1101-2021_01_04_425177 107 4 : : : 10_1101-2021_01_04_425177 107 5 The the DT 10_1101-2021_01_04_425177 107 6 authors author NNS 10_1101-2021_01_04_425177 107 7 declare declare VBP 10_1101-2021_01_04_425177 107 8 no no DT 10_1101-2021_01_04_425177 107 9 conflict conflict NN 10_1101-2021_01_04_425177 107 10 of of IN 10_1101-2021_01_04_425177 107 11 interests interest NNS 10_1101-2021_01_04_425177 107 12 . . . 10_1101-2021_01_04_425177 108 1 .CC .CC NFP 10_1101-2021_01_04_425177 108 2 - - : 10_1101-2021_01_04_425177 108 3 BY by IN 10_1101-2021_01_04_425177 108 4 - - HYPH 10_1101-2021_01_04_425177 108 5 NC NC NNP 10_1101-2021_01_04_425177 108 6 - - HYPH 10_1101-2021_01_04_425177 108 7 ND ND NNP 10_1101-2021_01_04_425177 108 8 4.0 4.0 CD 10_1101-2021_01_04_425177 108 9 International international JJ 10_1101-2021_01_04_425177 108 10 licensemade licensemade NN 10_1101-2021_01_04_425177 108 11 available available JJ 10_1101-2021_01_04_425177 108 12 under under IN 10_1101-2021_01_04_425177 108 13 a a DT 10_1101-2021_01_04_425177 108 14 ( ( -LRB- 10_1101-2021_01_04_425177 108 15 which which WDT 10_1101-2021_01_04_425177 108 16 was be VBD 10_1101-2021_01_04_425177 108 17 not not RB 10_1101-2021_01_04_425177 108 18 certified certify VBN 10_1101-2021_01_04_425177 108 19 by by IN 10_1101-2021_01_04_425177 108 20 peer peer NN 10_1101-2021_01_04_425177 108 21 review review NN 10_1101-2021_01_04_425177 108 22 ) ) -RRB- 10_1101-2021_01_04_425177 108 23 is be VBZ 10_1101-2021_01_04_425177 108 24 the the DT 10_1101-2021_01_04_425177 108 25 author author NN 10_1101-2021_01_04_425177 108 26 / / SYM 10_1101-2021_01_04_425177 108 27 funder funder NN 10_1101-2021_01_04_425177 108 28 , , , 10_1101-2021_01_04_425177 108 29 who who WP 10_1101-2021_01_04_425177 108 30 has have VBZ 10_1101-2021_01_04_425177 108 31 granted grant VBN 10_1101-2021_01_04_425177 108 32 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 108 33 a a DT 10_1101-2021_01_04_425177 108 34 license license NN 10_1101-2021_01_04_425177 108 35 to to TO 10_1101-2021_01_04_425177 108 36 display display VB 10_1101-2021_01_04_425177 108 37 the the DT 10_1101-2021_01_04_425177 108 38 preprint preprint NN 10_1101-2021_01_04_425177 108 39 in in IN 10_1101-2021_01_04_425177 108 40 perpetuity perpetuity NN 10_1101-2021_01_04_425177 108 41 . . . 10_1101-2021_01_04_425177 109 1 It -PRON- PRP 10_1101-2021_01_04_425177 109 2 is be VBZ 10_1101-2021_01_04_425177 109 3 The the DT 10_1101-2021_01_04_425177 109 4 copyright copyright NN 10_1101-2021_01_04_425177 109 5 holder holder NN 10_1101-2021_01_04_425177 109 6 for for IN 10_1101-2021_01_04_425177 109 7 this this DT 10_1101-2021_01_04_425177 109 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 109 9 version version NN 10_1101-2021_01_04_425177 109 10 posted post VBD 10_1101-2021_01_04_425177 109 11 January January NNP 10_1101-2021_01_04_425177 109 12 4 4 CD 10_1101-2021_01_04_425177 109 13 , , , 10_1101-2021_01_04_425177 109 14 2021 2021 CD 10_1101-2021_01_04_425177 109 15 . . . 10_1101-2021_01_04_425177 109 16 ; ; : 10_1101-2021_01_04_425177 109 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 109 18 : : : 10_1101-2021_01_04_425177 109 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 109 20 preprint preprint NN 10_1101-2021_01_04_425177 109 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 VBZ 10_1101-2021_01_04_425177 109 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_04_425177 109 23 10 10 CD 10_1101-2021_01_04_425177 109 24 References reference NNS 10_1101-2021_01_04_425177 109 25 Ambadi Ambadi NNP 10_1101-2021_01_04_425177 109 26 Thody Thody NNP 10_1101-2021_01_04_425177 109 27 , , , 10_1101-2021_01_04_425177 109 28 S. S. NNP 10_1101-2021_01_04_425177 109 29 , , , 10_1101-2021_01_04_425177 109 30 Mathew Mathew NNP 10_1101-2021_01_04_425177 109 31 , , , 10_1101-2021_01_04_425177 109 32 M.K. M.K. NNP 10_1101-2021_01_04_425177 109 33 , , , 10_1101-2021_01_04_425177 109 34 Udgaonkar Udgaonkar NNP 10_1101-2021_01_04_425177 109 35 , , , 10_1101-2021_01_04_425177 109 36 J.B. J.B. NNP 10_1101-2021_01_04_425177 109 37 , , , 10_1101-2021_01_04_425177 109 38 2018 2018 CD 10_1101-2021_01_04_425177 109 39 . . . 10_1101-2021_01_04_425177 110 1 Mechanism mechanism NN 10_1101-2021_01_04_425177 110 2 of of IN 10_1101-2021_01_04_425177 110 3 aggregation aggregation NN 10_1101-2021_01_04_425177 110 4 and and CC 10_1101-2021_01_04_425177 110 5 membrane membrane NN 10_1101-2021_01_04_425177 110 6 interactions interaction NNS 10_1101-2021_01_04_425177 110 7 of of IN 10_1101-2021_01_04_425177 110 8 mammalian mammalian JJ 10_1101-2021_01_04_425177 110 9 prion prion NN 10_1101-2021_01_04_425177 110 10 protein protein NN 10_1101-2021_01_04_425177 110 11 . . . 10_1101-2021_01_04_425177 111 1 Biochim Biochim NNP 10_1101-2021_01_04_425177 111 2 Biophys Biophys NNP 10_1101-2021_01_04_425177 111 3 Acta Acta NNP 10_1101-2021_01_04_425177 111 4 Biomembr Biomembr NNP 10_1101-2021_01_04_425177 111 5 . . . 10_1101-2021_01_04_425177 112 1 Chemerovski Chemerovski NNP 10_1101-2021_01_04_425177 112 2 - - HYPH 10_1101-2021_01_04_425177 112 3 Glikman Glikman NNP 10_1101-2021_01_04_425177 112 4 , , , 10_1101-2021_01_04_425177 112 5 M. M. NNP 10_1101-2021_01_04_425177 112 6 , , , 10_1101-2021_01_04_425177 112 7 Rozentur Rozentur NNP 10_1101-2021_01_04_425177 112 8 - - HYPH 10_1101-2021_01_04_425177 112 9 Shkop Shkop NNP 10_1101-2021_01_04_425177 112 10 , , , 10_1101-2021_01_04_425177 112 11 E. E. NNP 10_1101-2021_01_04_425177 112 12 , , , 10_1101-2021_01_04_425177 112 13 Richman Richman NNP 10_1101-2021_01_04_425177 112 14 , , , 10_1101-2021_01_04_425177 112 15 M. M. NNP 10_1101-2021_01_04_425177 112 16 , , , 10_1101-2021_01_04_425177 112 17 Grupi Grupi NNP 10_1101-2021_01_04_425177 112 18 , , , 10_1101-2021_01_04_425177 112 19 A. A. NNP 10_1101-2021_01_04_425177 112 20 , , , 10_1101-2021_01_04_425177 112 21 Getler Getler NNP 10_1101-2021_01_04_425177 112 22 , , , 10_1101-2021_01_04_425177 112 23 A. A. NNP 10_1101-2021_01_04_425177 112 24 , , , 10_1101-2021_01_04_425177 112 25 Cohen Cohen NNP 10_1101-2021_01_04_425177 112 26 , , , 10_1101-2021_01_04_425177 112 27 H.Y. H.Y. NNP 10_1101-2021_01_04_425177 112 28 , , , 10_1101-2021_01_04_425177 112 29 Shaked Shaked NNP 10_1101-2021_01_04_425177 112 30 , , , 10_1101-2021_01_04_425177 112 31 H. H. NNP 10_1101-2021_01_04_425177 112 32 , , , 10_1101-2021_01_04_425177 112 33 Wallin Wallin NNP 10_1101-2021_01_04_425177 112 34 , , , 10_1101-2021_01_04_425177 112 35 C. C. NNP 10_1101-2021_01_04_425177 112 36 , , , 10_1101-2021_01_04_425177 112 37 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 112 38 , , , 10_1101-2021_01_04_425177 112 39 S.K. S.K. NNP 10_1101-2021_01_04_425177 112 40 , , , 10_1101-2021_01_04_425177 112 41 Haas Haas NNP 10_1101-2021_01_04_425177 112 42 , , , 10_1101-2021_01_04_425177 112 43 E. E. NNP 10_1101-2021_01_04_425177 112 44 , , , 10_1101-2021_01_04_425177 112 45 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 112 46 , , , 10_1101-2021_01_04_425177 112 47 A. A. NNP 10_1101-2021_01_04_425177 112 48 , , , 10_1101-2021_01_04_425177 112 49 Chill Chill NNP 10_1101-2021_01_04_425177 112 50 , , , 10_1101-2021_01_04_425177 112 51 J.H. J.H. NNP 10_1101-2021_01_04_425177 112 52 , , , 10_1101-2021_01_04_425177 112 53 Rahimipour Rahimipour NNP 10_1101-2021_01_04_425177 112 54 , , , 10_1101-2021_01_04_425177 112 55 S. S. NNP 10_1101-2021_01_04_425177 112 56 , , , 10_1101-2021_01_04_425177 112 57 2016 2016 CD 10_1101-2021_01_04_425177 112 58 . . . 10_1101-2021_01_04_425177 113 1 Self self NN 10_1101-2021_01_04_425177 113 2 - - HYPH 10_1101-2021_01_04_425177 113 3 Assembled assemble VBN 10_1101-2021_01_04_425177 113 4 Cyclic Cyclic NNP 10_1101-2021_01_04_425177 113 5 d d NNP 10_1101-2021_01_04_425177 113 6 , , , 10_1101-2021_01_04_425177 113 7 l l NN 10_1101-2021_01_04_425177 113 8 - - HYPH 10_1101-2021_01_04_425177 113 9 alpha alpha NN 10_1101-2021_01_04_425177 113 10 - - HYPH 10_1101-2021_01_04_425177 113 11 Peptides peptide NNS 10_1101-2021_01_04_425177 113 12 as as IN 10_1101-2021_01_04_425177 113 13 Generic Generic NNP 10_1101-2021_01_04_425177 113 14 Conformational Conformational NNP 10_1101-2021_01_04_425177 113 15 Inhibitors Inhibitors NNPS 10_1101-2021_01_04_425177 113 16 of of IN 10_1101-2021_01_04_425177 113 17 the the DT 10_1101-2021_01_04_425177 113 18 alpha alpha NN 10_1101-2021_01_04_425177 113 19 - - HYPH 10_1101-2021_01_04_425177 113 20 Synuclein Synuclein NNP 10_1101-2021_01_04_425177 113 21 Aggregation Aggregation NNP 10_1101-2021_01_04_425177 113 22 and and CC 10_1101-2021_01_04_425177 113 23 Toxicity Toxicity NNP 10_1101-2021_01_04_425177 113 24 : : : 10_1101-2021_01_04_425177 113 25 In in IN 10_1101-2021_01_04_425177 113 26 Vitro Vitro NNP 10_1101-2021_01_04_425177 113 27 and and CC 10_1101-2021_01_04_425177 113 28 Mechanistic Mechanistic NNP 10_1101-2021_01_04_425177 113 29 Studies Studies NNPS 10_1101-2021_01_04_425177 113 30 . . . 10_1101-2021_01_04_425177 114 1 Chemistry chemistry NN 10_1101-2021_01_04_425177 114 2 22 22 CD 10_1101-2021_01_04_425177 114 3 , , , 10_1101-2021_01_04_425177 114 4 14236 14236 CD 10_1101-2021_01_04_425177 114 5 - - SYM 10_1101-2021_01_04_425177 114 6 14246 14246 CD 10_1101-2021_01_04_425177 114 7 . . . 10_1101-2021_01_04_425177 115 1 Gasteiger Gasteiger NNP 10_1101-2021_01_04_425177 115 2 , , , 10_1101-2021_01_04_425177 115 3 E. E. NNP 10_1101-2021_01_04_425177 115 4 , , , 10_1101-2021_01_04_425177 115 5 Hoogland Hoogland NNP 10_1101-2021_01_04_425177 115 6 , , , 10_1101-2021_01_04_425177 115 7 C. C. NNP 10_1101-2021_01_04_425177 115 8 , , , 10_1101-2021_01_04_425177 115 9 Gattiker Gattiker NNP 10_1101-2021_01_04_425177 115 10 , , , 10_1101-2021_01_04_425177 115 11 A. a. NN 10_1101-2021_01_04_425177 115 12 , , , 10_1101-2021_01_04_425177 115 13 Duvaud Duvaud NNP 10_1101-2021_01_04_425177 115 14 , , , 10_1101-2021_01_04_425177 115 15 S.e S.e NNP 10_1101-2021_01_04_425177 115 16 . . NNP 10_1101-2021_01_04_425177 115 17 , , , 10_1101-2021_01_04_425177 115 18 Wilkins Wilkins NNP 10_1101-2021_01_04_425177 115 19 , , , 10_1101-2021_01_04_425177 115 20 M.R. M.R. NNP 10_1101-2021_01_04_425177 115 21 , , , 10_1101-2021_01_04_425177 115 22 Appel Appel NNP 10_1101-2021_01_04_425177 115 23 , , , 10_1101-2021_01_04_425177 115 24 R.D. R.D. NNP 10_1101-2021_01_04_425177 115 25 , , , 10_1101-2021_01_04_425177 115 26 Amos Amos NNP 10_1101-2021_01_04_425177 115 27 , , , 10_1101-2021_01_04_425177 115 28 B. B. NNP 10_1101-2021_01_04_425177 115 29 , , , 10_1101-2021_01_04_425177 115 30 2005 2005 CD 10_1101-2021_01_04_425177 115 31 . . . 10_1101-2021_01_04_425177 116 1 Protein Protein NNP 10_1101-2021_01_04_425177 116 2 Identification Identification NNP 10_1101-2021_01_04_425177 116 3 and and CC 10_1101-2021_01_04_425177 116 4 Analysis Analysis NNP 10_1101-2021_01_04_425177 116 5 Tools Tools NNPS 10_1101-2021_01_04_425177 116 6 on on IN 10_1101-2021_01_04_425177 116 7 the the DT 10_1101-2021_01_04_425177 116 8 ExPASy ExPASy NNP 10_1101-2021_01_04_425177 116 9 Server Server NNP 10_1101-2021_01_04_425177 116 10 , , , 10_1101-2021_01_04_425177 116 11 in in IN 10_1101-2021_01_04_425177 116 12 : : : 10_1101-2021_01_04_425177 116 13 Walker Walker NNP 10_1101-2021_01_04_425177 116 14 , , , 10_1101-2021_01_04_425177 116 15 J.M. J.M. NNP 10_1101-2021_01_04_425177 117 1 ( ( -LRB- 10_1101-2021_01_04_425177 117 2 Ed Ed NNP 10_1101-2021_01_04_425177 117 3 . . . 10_1101-2021_01_04_425177 118 1 ) ) -RRB- 10_1101-2021_01_04_425177 118 2 , , , 10_1101-2021_01_04_425177 118 3 The the DT 10_1101-2021_01_04_425177 118 4 Proteomics Proteomics NNPS 10_1101-2021_01_04_425177 118 5 Protocols Protocols NNPS 10_1101-2021_01_04_425177 118 6 Handbook Handbook NNP 10_1101-2021_01_04_425177 118 7 . . . 10_1101-2021_01_04_425177 119 1 Humana Humana NNP 10_1101-2021_01_04_425177 119 2 Press Press NNP 10_1101-2021_01_04_425177 119 3 , , , 10_1101-2021_01_04_425177 119 4 pp pp NNP 10_1101-2021_01_04_425177 119 5 . . . 10_1101-2021_01_04_425177 120 1 571 571 CD 10_1101-2021_01_04_425177 120 2 - - SYM 10_1101-2021_01_04_425177 120 3 607 607 CD 10_1101-2021_01_04_425177 120 4 . . . 10_1101-2021_01_04_425177 121 1 Gielnik Gielnik NNP 10_1101-2021_01_04_425177 121 2 , , , 10_1101-2021_01_04_425177 121 3 M. M. NNP 10_1101-2021_01_04_425177 121 4 , , , 10_1101-2021_01_04_425177 121 5 Pietralik Pietralik NNP 10_1101-2021_01_04_425177 121 6 , , , 10_1101-2021_01_04_425177 121 7 Z. Z. NNP 10_1101-2021_01_04_425177 121 8 , , , 10_1101-2021_01_04_425177 121 9 Zhukov Zhukov NNP 10_1101-2021_01_04_425177 121 10 , , , 10_1101-2021_01_04_425177 121 11 I. I. NNP 10_1101-2021_01_04_425177 121 12 , , , 10_1101-2021_01_04_425177 121 13 Szymańska Szymańska NNP 10_1101-2021_01_04_425177 121 14 , , , 10_1101-2021_01_04_425177 121 15 A. A. NNP 10_1101-2021_01_04_425177 121 16 , , , 10_1101-2021_01_04_425177 121 17 Kwiatek Kwiatek NNP 10_1101-2021_01_04_425177 121 18 , , , 10_1101-2021_01_04_425177 121 19 W.M. W.M. NNP 10_1101-2021_01_04_425177 121 20 , , , 10_1101-2021_01_04_425177 121 21 Kozak Kozak NNP 10_1101-2021_01_04_425177 121 22 , , , 10_1101-2021_01_04_425177 121 23 M. M. NNP 10_1101-2021_01_04_425177 121 24 , , , 10_1101-2021_01_04_425177 121 25 2019 2019 CD 10_1101-2021_01_04_425177 121 26 . . . 10_1101-2021_01_04_425177 122 1 PrP PrP NNP 10_1101-2021_01_04_425177 122 2 ( ( -LRB- 10_1101-2021_01_04_425177 122 3 58–93 58–93 CD 10_1101-2021_01_04_425177 122 4 ) ) -RRB- 10_1101-2021_01_04_425177 122 5 peptide peptide NN 10_1101-2021_01_04_425177 122 6 from from IN 10_1101-2021_01_04_425177 122 7 unstructured unstructured JJ 10_1101-2021_01_04_425177 122 8 N N NNP 10_1101-2021_01_04_425177 122 9 - - HYPH 10_1101-2021_01_04_425177 122 10 terminaldomain terminaldomain NNP 10_1101-2021_01_04_425177 122 11 of of IN 10_1101-2021_01_04_425177 122 12 human human JJ 10_1101-2021_01_04_425177 122 13 prion prion NN 10_1101-2021_01_04_425177 122 14 protein protein NN 10_1101-2021_01_04_425177 122 15 forms form NNS 10_1101-2021_01_04_425177 122 16 amyloid- amyloid- VBP 10_1101-2021_01_04_425177 122 17 likefibrillar likefibrillar JJ 10_1101-2021_01_04_425177 122 18 structures structure NNS 10_1101-2021_01_04_425177 122 19 in in IN 10_1101-2021_01_04_425177 122 20 the the DT 10_1101-2021_01_04_425177 122 21 presence presence NN 10_1101-2021_01_04_425177 122 22 of of IN 10_1101-2021_01_04_425177 122 23 Zn2+ions zn2+ion NNS 10_1101-2021_01_04_425177 122 24 . . . 10_1101-2021_01_04_425177 123 1 RSC RSC NNP 10_1101-2021_01_04_425177 123 2 Advances Advances NNP 10_1101-2021_01_04_425177 123 3 9 9 CD 10_1101-2021_01_04_425177 123 4 , , , 10_1101-2021_01_04_425177 123 5 22211–22219 22211–22219 CD 10_1101-2021_01_04_425177 123 6 . . . 10_1101-2021_01_04_425177 124 1 Henning Henning NNP 10_1101-2021_01_04_425177 124 2 - - HYPH 10_1101-2021_01_04_425177 124 3 Knechtel Knechtel NNP 10_1101-2021_01_04_425177 124 4 , , , 10_1101-2021_01_04_425177 124 5 A. A. NNP 10_1101-2021_01_04_425177 124 6 , , , 10_1101-2021_01_04_425177 124 7 Kumar Kumar NNP 10_1101-2021_01_04_425177 124 8 , , , 10_1101-2021_01_04_425177 124 9 S. S. NNP 10_1101-2021_01_04_425177 124 10 , , , 10_1101-2021_01_04_425177 124 11 Wallin Wallin NNP 10_1101-2021_01_04_425177 124 12 , , , 10_1101-2021_01_04_425177 124 13 C. C. NNP 10_1101-2021_01_04_425177 124 14 , , , 10_1101-2021_01_04_425177 124 15 Król Król NNP 10_1101-2021_01_04_425177 124 16 , , , 10_1101-2021_01_04_425177 124 17 S. S. NNP 10_1101-2021_01_04_425177 124 18 , , , 10_1101-2021_01_04_425177 124 19 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 124 20 , , , 10_1101-2021_01_04_425177 124 21 S. S. NNP 10_1101-2021_01_04_425177 124 22 , , , 10_1101-2021_01_04_425177 124 23 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 124 24 , , , 10_1101-2021_01_04_425177 124 25 J. J. NNP 10_1101-2021_01_04_425177 124 26 , , , 10_1101-2021_01_04_425177 124 27 Esposito Esposito NNP 10_1101-2021_01_04_425177 124 28 , , , 10_1101-2021_01_04_425177 124 29 G. G. NNP 10_1101-2021_01_04_425177 124 30 , , , 10_1101-2021_01_04_425177 124 31 Kirmizialtin Kirmizialtin NNP 10_1101-2021_01_04_425177 124 32 , , , 10_1101-2021_01_04_425177 124 33 S. S. NNP 10_1101-2021_01_04_425177 124 34 , , , 10_1101-2021_01_04_425177 124 35 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 124 36 , , , 10_1101-2021_01_04_425177 124 37 A. A. NNP 10_1101-2021_01_04_425177 124 38 , , , 10_1101-2021_01_04_425177 124 39 Hamilton Hamilton NNP 10_1101-2021_01_04_425177 124 40 , , , 10_1101-2021_01_04_425177 124 41 A.D. A.D. NNP 10_1101-2021_01_04_425177 124 42 , , , 10_1101-2021_01_04_425177 124 43 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 124 44 , , , 10_1101-2021_01_04_425177 124 45 M. M. NNP 10_1101-2021_01_04_425177 124 46 , , , 10_1101-2021_01_04_425177 124 47 2020 2020 CD 10_1101-2021_01_04_425177 124 48 . . . 10_1101-2021_01_04_425177 125 1 Designed design VBN 10_1101-2021_01_04_425177 125 2 cell cell NN 10_1101-2021_01_04_425177 125 3 - - HYPH 10_1101-2021_01_04_425177 125 4 penetrating penetrate VBG 10_1101-2021_01_04_425177 125 5 peptide peptide JJ 10_1101-2021_01_04_425177 125 6 inhibitors inhibitor NNS 10_1101-2021_01_04_425177 125 7 of of IN 10_1101-2021_01_04_425177 125 8 amyloid amyloid JJ 10_1101-2021_01_04_425177 125 9 - - HYPH 10_1101-2021_01_04_425177 125 10 beta beta NN 10_1101-2021_01_04_425177 125 11 aggregation aggregation NN 10_1101-2021_01_04_425177 125 12 and and CC 10_1101-2021_01_04_425177 125 13 cytotoxicity cytotoxicity NN 10_1101-2021_01_04_425177 125 14 . . . 10_1101-2021_01_04_425177 126 1 Cell Cell NNP 10_1101-2021_01_04_425177 126 2 Reports report VBZ 10_1101-2021_01_04_425177 126 3 Physical Physical NNP 10_1101-2021_01_04_425177 126 4 Science Science NNP 10_1101-2021_01_04_425177 126 5 1 1 CD 10_1101-2021_01_04_425177 126 6 , , , 10_1101-2021_01_04_425177 126 7 100014 100014 CD 10_1101-2021_01_04_425177 126 8 . . . 10_1101-2021_01_04_425177 127 1 Horvath Horvath NNP 10_1101-2021_01_04_425177 127 2 , , , 10_1101-2021_01_04_425177 127 3 I. I. NNP 10_1101-2021_01_04_425177 127 4 , , , 10_1101-2021_01_04_425177 127 5 Iashchishyn Iashchishyn NNP 10_1101-2021_01_04_425177 127 6 , , , 10_1101-2021_01_04_425177 127 7 I.A. I.A. NNP 10_1101-2021_01_04_425177 127 8 , , , 10_1101-2021_01_04_425177 127 9 Moskalenko Moskalenko NNP 10_1101-2021_01_04_425177 127 10 , , , 10_1101-2021_01_04_425177 127 11 R.A. R.A. NNP 10_1101-2021_01_04_425177 127 12 , , , 10_1101-2021_01_04_425177 127 13 Wang Wang NNP 10_1101-2021_01_04_425177 127 14 , , , 10_1101-2021_01_04_425177 127 15 C. C. NNP 10_1101-2021_01_04_425177 127 16 , , , 10_1101-2021_01_04_425177 127 17 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 127 18 , , , 10_1101-2021_01_04_425177 127 19 S.K.T.S. S.K.T.S. NNP 10_1101-2021_01_04_425177 127 20 , , , 10_1101-2021_01_04_425177 127 21 Wallin Wallin NNP 10_1101-2021_01_04_425177 127 22 , , , 10_1101-2021_01_04_425177 127 23 C. C. NNP 10_1101-2021_01_04_425177 127 24 , , , 10_1101-2021_01_04_425177 127 25 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 127 26 , , , 10_1101-2021_01_04_425177 127 27 A. A. NNP 10_1101-2021_01_04_425177 127 28 , , , 10_1101-2021_01_04_425177 127 29 Kovacs Kovacs NNP 10_1101-2021_01_04_425177 127 30 , , , 10_1101-2021_01_04_425177 127 31 G.G. G.G. NNP 10_1101-2021_01_04_425177 127 32 , , , 10_1101-2021_01_04_425177 127 33 Morozova Morozova NNP 10_1101-2021_01_04_425177 127 34 - - HYPH 10_1101-2021_01_04_425177 127 35 Roche Roche NNP 10_1101-2021_01_04_425177 127 36 , , , 10_1101-2021_01_04_425177 127 37 L.A. L.A. NNP 10_1101-2021_01_04_425177 127 38 , , , 10_1101-2021_01_04_425177 127 39 2018 2018 CD 10_1101-2021_01_04_425177 127 40 . . . 10_1101-2021_01_04_425177 128 1 Co co NN 10_1101-2021_01_04_425177 128 2 - - NN 10_1101-2021_01_04_425177 128 3 aggregation aggregation NN 10_1101-2021_01_04_425177 128 4 of of IN 10_1101-2021_01_04_425177 128 5 pro pro JJ 10_1101-2021_01_04_425177 128 6 - - JJ 10_1101-2021_01_04_425177 128 7 inflammatory inflammatory JJ 10_1101-2021_01_04_425177 128 8 S100A9 s100a9 NN 10_1101-2021_01_04_425177 128 9 with with IN 10_1101-2021_01_04_425177 128 10 alpha alpha NN 10_1101-2021_01_04_425177 128 11 - - HYPH 10_1101-2021_01_04_425177 128 12 synuclein synuclein NNS 10_1101-2021_01_04_425177 128 13 in in IN 10_1101-2021_01_04_425177 128 14 Parkinson Parkinson NNP 10_1101-2021_01_04_425177 128 15 's 's POS 10_1101-2021_01_04_425177 128 16 disease disease NN 10_1101-2021_01_04_425177 128 17 : : : 10_1101-2021_01_04_425177 128 18 ex ex NNP 10_1101-2021_01_04_425177 128 19 vivo vivo NNP 10_1101-2021_01_04_425177 128 20 and and CC 10_1101-2021_01_04_425177 128 21 in in FW 10_1101-2021_01_04_425177 128 22 vitro vitro FW 10_1101-2021_01_04_425177 128 23 studies study NNS 10_1101-2021_01_04_425177 128 24 . . . 10_1101-2021_01_04_425177 129 1 J J NNP 10_1101-2021_01_04_425177 129 2 Neuroinflammation Neuroinflammation NNP 10_1101-2021_01_04_425177 129 3 15 15 CD 10_1101-2021_01_04_425177 129 4 , , , 10_1101-2021_01_04_425177 129 5 172 172 CD 10_1101-2021_01_04_425177 129 6 . . . 10_1101-2021_01_04_425177 130 1 Hyeon Hyeon NNP 10_1101-2021_01_04_425177 130 2 , , , 10_1101-2021_01_04_425177 130 3 J.W. J.W. NNP 10_1101-2021_01_04_425177 130 4 , , , 10_1101-2021_01_04_425177 130 5 Noh Noh NNP 10_1101-2021_01_04_425177 130 6 , , , 10_1101-2021_01_04_425177 130 7 R. R. NNP 10_1101-2021_01_04_425177 130 8 , , , 10_1101-2021_01_04_425177 130 9 Choi Choi NNP 10_1101-2021_01_04_425177 130 10 , , , 10_1101-2021_01_04_425177 130 11 J. J. NNP 10_1101-2021_01_04_425177 130 12 , , , 10_1101-2021_01_04_425177 130 13 Lee Lee NNP 10_1101-2021_01_04_425177 130 14 , , , 10_1101-2021_01_04_425177 130 15 S.M. S.M. NNP 10_1101-2021_01_04_425177 130 16 , , , 10_1101-2021_01_04_425177 130 17 Lee Lee NNP 10_1101-2021_01_04_425177 130 18 , , , 10_1101-2021_01_04_425177 130 19 Y.S. Y.S. NNP 10_1101-2021_01_04_425177 130 20 , , , 10_1101-2021_01_04_425177 130 21 An An NNP 10_1101-2021_01_04_425177 130 22 , , , 10_1101-2021_01_04_425177 130 23 S.S.A. S.S.A. NNP 10_1101-2021_01_04_425177 130 24 , , , 10_1101-2021_01_04_425177 130 25 No No NNP 10_1101-2021_01_04_425177 130 26 , , , 10_1101-2021_01_04_425177 130 27 K.T. K.T. NNP 10_1101-2021_01_04_425177 130 28 , , , 10_1101-2021_01_04_425177 130 29 Lee Lee NNP 10_1101-2021_01_04_425177 130 30 , , , 10_1101-2021_01_04_425177 130 31 J. J. NNP 10_1101-2021_01_04_425177 130 32 , , , 10_1101-2021_01_04_425177 130 33 2020 2020 CD 10_1101-2021_01_04_425177 130 34 . . . 10_1101-2021_01_04_425177 131 1 BMD42 BMD42 NNP 10_1101-2021_01_04_425177 131 2 - - HYPH 10_1101-2021_01_04_425177 131 3 2910 2910 CD 10_1101-2021_01_04_425177 131 4 , , , 10_1101-2021_01_04_425177 131 5 a a DT 10_1101-2021_01_04_425177 131 6 Novel Novel NNP 10_1101-2021_01_04_425177 131 7 Benzoxazole Benzoxazole NNP 10_1101-2021_01_04_425177 131 8 Derivative Derivative NNP 10_1101-2021_01_04_425177 131 9 , , , 10_1101-2021_01_04_425177 131 10 Shows show VBZ 10_1101-2021_01_04_425177 131 11 a a DT 10_1101-2021_01_04_425177 131 12 Potent Potent NNP 10_1101-2021_01_04_425177 131 13 Anti Anti NNP 10_1101-2021_01_04_425177 131 14 - - NN 10_1101-2021_01_04_425177 131 15 prion prion NN 10_1101-2021_01_04_425177 131 16 Activity Activity NNP 10_1101-2021_01_04_425177 131 17 and and CC 10_1101-2021_01_04_425177 131 18 Prolongs Prolongs NNPS 10_1101-2021_01_04_425177 131 19 the the DT 10_1101-2021_01_04_425177 131 20 Mean Mean NNP 10_1101-2021_01_04_425177 131 21 Survival Survival NNP 10_1101-2021_01_04_425177 131 22 in in IN 10_1101-2021_01_04_425177 131 23 an an DT 10_1101-2021_01_04_425177 131 24 Animal Animal NNP 10_1101-2021_01_04_425177 131 25 Model model NN 10_1101-2021_01_04_425177 131 26 of of IN 10_1101-2021_01_04_425177 131 27 Prion Prion NNP 10_1101-2021_01_04_425177 131 28 Disease Disease NNP 10_1101-2021_01_04_425177 131 29 . . . 10_1101-2021_01_04_425177 132 1 Exp Exp NNP 10_1101-2021_01_04_425177 132 2 Neurobiol Neurobiol NNP 10_1101-2021_01_04_425177 132 3 29 29 CD 10_1101-2021_01_04_425177 132 4 , , , 10_1101-2021_01_04_425177 132 5 93 93 CD 10_1101-2021_01_04_425177 132 6 - - SYM 10_1101-2021_01_04_425177 132 7 105 105 CD 10_1101-2021_01_04_425177 132 8 . . . 10_1101-2021_01_04_425177 133 1 Jaunmuktane Jaunmuktane NNP 10_1101-2021_01_04_425177 133 2 , , , 10_1101-2021_01_04_425177 133 3 Z. Z. NNP 10_1101-2021_01_04_425177 133 4 , , , 10_1101-2021_01_04_425177 133 5 Brandner Brandner NNP 10_1101-2021_01_04_425177 133 6 , , , 10_1101-2021_01_04_425177 133 7 S. S. NNP 10_1101-2021_01_04_425177 133 8 , , , 10_1101-2021_01_04_425177 133 9 2019 2019 CD 10_1101-2021_01_04_425177 133 10 . . . 10_1101-2021_01_04_425177 134 1 The the DT 10_1101-2021_01_04_425177 134 2 role role NN 10_1101-2021_01_04_425177 134 3 of of IN 10_1101-2021_01_04_425177 134 4 prion prion NN 10_1101-2021_01_04_425177 134 5 - - HYPH 10_1101-2021_01_04_425177 134 6 like like JJ 10_1101-2021_01_04_425177 134 7 mechanisms mechanism NNS 10_1101-2021_01_04_425177 134 8 in in IN 10_1101-2021_01_04_425177 134 9 neurodegenerative neurodegenerative JJ 10_1101-2021_01_04_425177 134 10 diseases disease NNS 10_1101-2021_01_04_425177 134 11 . . . 10_1101-2021_01_04_425177 135 1 Neuropathol Neuropathol NNP 10_1101-2021_01_04_425177 135 2 Appl Appl NNP 10_1101-2021_01_04_425177 135 3 Neurobiol Neurobiol NNP 10_1101-2021_01_04_425177 135 4 . . . 10_1101-2021_01_04_425177 136 1 Jucker Jucker NNP 10_1101-2021_01_04_425177 136 2 , , , 10_1101-2021_01_04_425177 136 3 M. M. NNP 10_1101-2021_01_04_425177 136 4 , , , 10_1101-2021_01_04_425177 136 5 Walker Walker NNP 10_1101-2021_01_04_425177 136 6 , , , 10_1101-2021_01_04_425177 136 7 L.C. L.C. NNP 10_1101-2021_01_04_425177 136 8 , , , 10_1101-2021_01_04_425177 136 9 2018 2018 CD 10_1101-2021_01_04_425177 136 10 . . . 10_1101-2021_01_04_425177 137 1 Propagation propagation NN 10_1101-2021_01_04_425177 137 2 and and CC 10_1101-2021_01_04_425177 137 3 spread spread NN 10_1101-2021_01_04_425177 137 4 of of IN 10_1101-2021_01_04_425177 137 5 pathogenic pathogenic JJ 10_1101-2021_01_04_425177 137 6 protein protein NN 10_1101-2021_01_04_425177 137 7 assemblies assembly NNS 10_1101-2021_01_04_425177 137 8 in in IN 10_1101-2021_01_04_425177 137 9 neurodegenerative neurodegenerative JJ 10_1101-2021_01_04_425177 137 10 diseases disease NNS 10_1101-2021_01_04_425177 137 11 . . . 10_1101-2021_01_04_425177 138 1 Nat Nat NNP 10_1101-2021_01_04_425177 138 2 Neurosci Neurosci NNP 10_1101-2021_01_04_425177 138 3 21 21 CD 10_1101-2021_01_04_425177 138 4 , , , 10_1101-2021_01_04_425177 138 5 1341 1341 CD 10_1101-2021_01_04_425177 138 6 - - SYM 10_1101-2021_01_04_425177 138 7 1349 1349 CD 10_1101-2021_01_04_425177 138 8 . . . 10_1101-2021_01_04_425177 139 1 Julien Julien NNP 10_1101-2021_01_04_425177 139 2 , , , 10_1101-2021_01_04_425177 139 3 O. O. NNP 10_1101-2021_01_04_425177 139 4 , , , 10_1101-2021_01_04_425177 139 5 Chatterjee Chatterjee NNP 10_1101-2021_01_04_425177 139 6 , , , 10_1101-2021_01_04_425177 139 7 S. S. NNP 10_1101-2021_01_04_425177 139 8 , , , 10_1101-2021_01_04_425177 139 9 Thiessen Thiessen NNP 10_1101-2021_01_04_425177 139 10 , , , 10_1101-2021_01_04_425177 139 11 A. a. NN 10_1101-2021_01_04_425177 139 12 , , , 10_1101-2021_01_04_425177 139 13 Graether Graether NNP 10_1101-2021_01_04_425177 139 14 , , , 10_1101-2021_01_04_425177 139 15 S.P. S.P. NNP 10_1101-2021_01_04_425177 139 16 , , , 10_1101-2021_01_04_425177 139 17 Sykes Sykes NNP 10_1101-2021_01_04_425177 139 18 , , , 10_1101-2021_01_04_425177 139 19 B.D. B.D. NNP 10_1101-2021_01_04_425177 139 20 , , , 10_1101-2021_01_04_425177 139 21 2009 2009 CD 10_1101-2021_01_04_425177 139 22 . . . 10_1101-2021_01_04_425177 140 1 Differential differential JJ 10_1101-2021_01_04_425177 140 2 stability stability NN 10_1101-2021_01_04_425177 140 3 of of IN 10_1101-2021_01_04_425177 140 4 the the DT 10_1101-2021_01_04_425177 140 5 bovine bovine JJ 10_1101-2021_01_04_425177 140 6 prion prion NN 10_1101-2021_01_04_425177 140 7 protein protein NN 10_1101-2021_01_04_425177 140 8 upon upon IN 10_1101-2021_01_04_425177 140 9 urea urea NNP 10_1101-2021_01_04_425177 140 10 unfolding unfold VBG 10_1101-2021_01_04_425177 140 11 . . . 10_1101-2021_01_04_425177 141 1 Protein Protein NNP 10_1101-2021_01_04_425177 141 2 Sci Sci NNP 10_1101-2021_01_04_425177 141 3 18 18 CD 10_1101-2021_01_04_425177 141 4 , , , 10_1101-2021_01_04_425177 141 5 2172 2172 CD 10_1101-2021_01_04_425177 141 6 - - SYM 10_1101-2021_01_04_425177 141 7 2182 2182 CD 10_1101-2021_01_04_425177 141 8 . . . 10_1101-2021_01_04_425177 142 1 Kristensen Kristensen NNP 10_1101-2021_01_04_425177 142 2 , , , 10_1101-2021_01_04_425177 142 3 M. M. NNP 10_1101-2021_01_04_425177 142 4 , , , 10_1101-2021_01_04_425177 142 5 Birch Birch NNP 10_1101-2021_01_04_425177 142 6 , , , 10_1101-2021_01_04_425177 142 7 D. D. NNP 10_1101-2021_01_04_425177 142 8 , , , 10_1101-2021_01_04_425177 142 9 Morck Morck NNP 10_1101-2021_01_04_425177 142 10 Nielsen Nielsen NNP 10_1101-2021_01_04_425177 142 11 , , , 10_1101-2021_01_04_425177 142 12 H. H. NNP 10_1101-2021_01_04_425177 142 13 , , , 10_1101-2021_01_04_425177 142 14 2016 2016 CD 10_1101-2021_01_04_425177 142 15 . . . 10_1101-2021_01_04_425177 143 1 Applications application NNS 10_1101-2021_01_04_425177 143 2 and and CC 10_1101-2021_01_04_425177 143 3 Challenges Challenges NNPS 10_1101-2021_01_04_425177 143 4 for for IN 10_1101-2021_01_04_425177 143 5 Use Use NNP 10_1101-2021_01_04_425177 143 6 of of IN 10_1101-2021_01_04_425177 143 7 Cell- Cell- NNP 10_1101-2021_01_04_425177 143 8 Penetrating Penetrating NNP 10_1101-2021_01_04_425177 143 9 Peptides Peptides NNPS 10_1101-2021_01_04_425177 143 10 as as IN 10_1101-2021_01_04_425177 143 11 Delivery Delivery NNP 10_1101-2021_01_04_425177 143 12 Vectors Vectors NNPS 10_1101-2021_01_04_425177 143 13 for for IN 10_1101-2021_01_04_425177 143 14 Peptide Peptide NNP 10_1101-2021_01_04_425177 143 15 and and CC 10_1101-2021_01_04_425177 143 16 Protein Protein NNP 10_1101-2021_01_04_425177 143 17 Cargos Cargos NNP 10_1101-2021_01_04_425177 143 18 . . . 10_1101-2021_01_04_425177 144 1 Int Int NNP 10_1101-2021_01_04_425177 144 2 J J NNP 10_1101-2021_01_04_425177 144 3 Mol Mol NNP 10_1101-2021_01_04_425177 144 4 Sci Sci NNP 10_1101-2021_01_04_425177 144 5 17 17 CD 10_1101-2021_01_04_425177 144 6 . . . 10_1101-2021_01_04_425177 145 1 Lee Lee NNP 10_1101-2021_01_04_425177 145 2 , , , 10_1101-2021_01_04_425177 145 3 S.M. S.M. NNP 10_1101-2021_01_04_425177 145 4 , , , 10_1101-2021_01_04_425177 145 5 Kim Kim NNP 10_1101-2021_01_04_425177 145 6 , , , 10_1101-2021_01_04_425177 145 7 S.S. S.S. NNP 10_1101-2021_01_04_425177 145 8 , , , 10_1101-2021_01_04_425177 145 9 Kim Kim NNP 10_1101-2021_01_04_425177 145 10 , , , 10_1101-2021_01_04_425177 145 11 H. H. NNP 10_1101-2021_01_04_425177 145 12 , , , 10_1101-2021_01_04_425177 145 13 Kim Kim NNP 10_1101-2021_01_04_425177 145 14 , , , 10_1101-2021_01_04_425177 145 15 S.Y. S.Y. NNP 10_1101-2021_01_04_425177 145 16 , , , 10_1101-2021_01_04_425177 145 17 2019 2019 CD 10_1101-2021_01_04_425177 145 18 . . . 10_1101-2021_01_04_425177 146 1 THERPA THERPA NNS 10_1101-2021_01_04_425177 146 2 v2 v2 NN 10_1101-2021_01_04_425177 146 3 : : : 10_1101-2021_01_04_425177 146 4 an an DT 10_1101-2021_01_04_425177 146 5 update update NN 10_1101-2021_01_04_425177 146 6 of of IN 10_1101-2021_01_04_425177 146 7 a a DT 10_1101-2021_01_04_425177 146 8 small small JJ 10_1101-2021_01_04_425177 146 9 molecule molecule NN 10_1101-2021_01_04_425177 146 10 database database NN 10_1101-2021_01_04_425177 146 11 related relate VBN 10_1101-2021_01_04_425177 146 12 to to IN 10_1101-2021_01_04_425177 146 13 prion prion NN 10_1101-2021_01_04_425177 146 14 protein protein NN 10_1101-2021_01_04_425177 146 15 regulation regulation NN 10_1101-2021_01_04_425177 146 16 and and CC 10_1101-2021_01_04_425177 146 17 prion prion NN 10_1101-2021_01_04_425177 146 18 disease disease NNP 10_1101-2021_01_04_425177 146 19 progression progression NN 10_1101-2021_01_04_425177 146 20 . . . 10_1101-2021_01_04_425177 147 1 Prion prion NN 10_1101-2021_01_04_425177 147 2 13 13 CD 10_1101-2021_01_04_425177 147 3 , , , 10_1101-2021_01_04_425177 147 4 197 197 CD 10_1101-2021_01_04_425177 147 5 - - SYM 10_1101-2021_01_04_425177 147 6 198 198 CD 10_1101-2021_01_04_425177 147 7 . . . 10_1101-2021_01_04_425177 148 1 Lundberg Lundberg NNP 10_1101-2021_01_04_425177 148 2 , , , 10_1101-2021_01_04_425177 148 3 P. P. NNP 10_1101-2021_01_04_425177 148 4 , , , 10_1101-2021_01_04_425177 148 5 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 148 6 , , , 10_1101-2021_01_04_425177 148 7 M. M. NNP 10_1101-2021_01_04_425177 148 8 , , , 10_1101-2021_01_04_425177 148 9 Lindberg Lindberg NNP 10_1101-2021_01_04_425177 148 10 , , , 10_1101-2021_01_04_425177 148 11 M. M. NNP 10_1101-2021_01_04_425177 148 12 , , , 10_1101-2021_01_04_425177 148 13 Hallbrink Hallbrink NNP 10_1101-2021_01_04_425177 148 14 , , , 10_1101-2021_01_04_425177 148 15 M. M. NNP 10_1101-2021_01_04_425177 148 16 , , , 10_1101-2021_01_04_425177 148 17 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 148 18 , , , 10_1101-2021_01_04_425177 148 19 J. J. NNP 10_1101-2021_01_04_425177 148 20 , , , 10_1101-2021_01_04_425177 148 21 Eriksson Eriksson NNP 10_1101-2021_01_04_425177 148 22 , , , 10_1101-2021_01_04_425177 148 23 L.E. L.E. NNP 10_1101-2021_01_04_425177 148 24 , , , 10_1101-2021_01_04_425177 148 25 Langel Langel NNP 10_1101-2021_01_04_425177 148 26 , , , 10_1101-2021_01_04_425177 148 27 U. U. NNP 10_1101-2021_01_04_425177 148 28 , , , 10_1101-2021_01_04_425177 148 29 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 148 30 , , , 10_1101-2021_01_04_425177 148 31 A. a. NN 10_1101-2021_01_04_425177 148 32 , , , 10_1101-2021_01_04_425177 148 33 2002 2002 CD 10_1101-2021_01_04_425177 148 34 . . . 10_1101-2021_01_04_425177 149 1 Cell cell NN 10_1101-2021_01_04_425177 149 2 membrane membrane NN 10_1101-2021_01_04_425177 149 3 translocation translocation NN 10_1101-2021_01_04_425177 149 4 of of IN 10_1101-2021_01_04_425177 149 5 the the DT 10_1101-2021_01_04_425177 149 6 N n NN 10_1101-2021_01_04_425177 149 7 - - HYPH 10_1101-2021_01_04_425177 149 8 terminal terminal NN 10_1101-2021_01_04_425177 149 9 ( ( -LRB- 10_1101-2021_01_04_425177 149 10 1 1 CD 10_1101-2021_01_04_425177 149 11 - - SYM 10_1101-2021_01_04_425177 149 12 28 28 CD 10_1101-2021_01_04_425177 149 13 ) ) -RRB- 10_1101-2021_01_04_425177 149 14 part part NN 10_1101-2021_01_04_425177 149 15 of of IN 10_1101-2021_01_04_425177 149 16 the the DT 10_1101-2021_01_04_425177 149 17 prion prion NN 10_1101-2021_01_04_425177 149 18 protein protein NN 10_1101-2021_01_04_425177 149 19 . . . 10_1101-2021_01_04_425177 150 1 Biochem Biochem NNP 10_1101-2021_01_04_425177 150 2 Biophys Biophys NNP 10_1101-2021_01_04_425177 150 3 Res Res NNP 10_1101-2021_01_04_425177 150 4 Commun Commun NNP 10_1101-2021_01_04_425177 150 5 299 299 CD 10_1101-2021_01_04_425177 150 6 , , , 10_1101-2021_01_04_425177 150 7 85 85 CD 10_1101-2021_01_04_425177 150 8 - - SYM 10_1101-2021_01_04_425177 150 9 90 90 CD 10_1101-2021_01_04_425177 150 10 . . . 10_1101-2021_01_04_425177 151 1 Luo Luo NNP 10_1101-2021_01_04_425177 151 2 , , , 10_1101-2021_01_04_425177 151 3 J. J. NNP 10_1101-2021_01_04_425177 151 4 , , , 10_1101-2021_01_04_425177 151 5 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 151 6 , , , 10_1101-2021_01_04_425177 151 7 S.K. S.K. NNP 10_1101-2021_01_04_425177 151 8 , , , 10_1101-2021_01_04_425177 151 9 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 151 10 , , , 10_1101-2021_01_04_425177 151 11 A. a. NN 10_1101-2021_01_04_425177 151 12 , , , 10_1101-2021_01_04_425177 151 13 Abrahams Abrahams NNP 10_1101-2021_01_04_425177 151 14 , , , 10_1101-2021_01_04_425177 151 15 J.P. J.P. NNP 10_1101-2021_01_04_425177 151 16 , , , 10_1101-2021_01_04_425177 151 17 2014 2014 CD 10_1101-2021_01_04_425177 151 18 . . . 10_1101-2021_01_04_425177 152 1 Alzheimer Alzheimer NNP 10_1101-2021_01_04_425177 152 2 peptides peptide NNS 10_1101-2021_01_04_425177 152 3 aggregate aggregate VBP 10_1101-2021_01_04_425177 152 4 into into IN 10_1101-2021_01_04_425177 152 5 transient transient JJ 10_1101-2021_01_04_425177 152 6 nanoglobules nanoglobule NNS 10_1101-2021_01_04_425177 152 7 that that WDT 10_1101-2021_01_04_425177 152 8 nucleate nucleate VBP 10_1101-2021_01_04_425177 152 9 fibrils fibril VBZ 10_1101-2021_01_04_425177 152 10 . . . 10_1101-2021_01_04_425177 153 1 Biochemistry Biochemistry NNP 10_1101-2021_01_04_425177 153 2 53 53 CD 10_1101-2021_01_04_425177 153 3 , , , 10_1101-2021_01_04_425177 153 4 6302 6302 CD 10_1101-2021_01_04_425177 153 5 - - SYM 10_1101-2021_01_04_425177 153 6 6308 6308 CD 10_1101-2021_01_04_425177 153 7 . . . 10_1101-2021_01_04_425177 154 1 Luo Luo NNP 10_1101-2021_01_04_425177 154 2 , , , 10_1101-2021_01_04_425177 154 3 J. J. NNP 10_1101-2021_01_04_425177 154 4 , , , 10_1101-2021_01_04_425177 154 5 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 154 6 , , , 10_1101-2021_01_04_425177 154 7 S.K. S.K. NNP 10_1101-2021_01_04_425177 154 8 , , , 10_1101-2021_01_04_425177 154 9 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 154 10 , , , 10_1101-2021_01_04_425177 154 11 A. a. NN 10_1101-2021_01_04_425177 154 12 , , , 10_1101-2021_01_04_425177 154 13 Abrahams Abrahams NNP 10_1101-2021_01_04_425177 154 14 , , , 10_1101-2021_01_04_425177 154 15 J.P. J.P. NNP 10_1101-2021_01_04_425177 154 16 , , , 10_1101-2021_01_04_425177 154 17 2016 2016 CD 10_1101-2021_01_04_425177 154 18 . . . 10_1101-2021_01_04_425177 155 1 Reciprocal Reciprocal NNP 10_1101-2021_01_04_425177 155 2 Molecular Molecular NNP 10_1101-2021_01_04_425177 155 3 Interactions Interactions NNPS 10_1101-2021_01_04_425177 155 4 between between IN 10_1101-2021_01_04_425177 155 5 the the DT 10_1101-2021_01_04_425177 155 6 Abeta Abeta NNP 10_1101-2021_01_04_425177 155 7 Peptide Peptide NNP 10_1101-2021_01_04_425177 155 8 Linked link VBN 10_1101-2021_01_04_425177 155 9 to to IN 10_1101-2021_01_04_425177 155 10 Alzheimer Alzheimer NNP 10_1101-2021_01_04_425177 155 11 's 's POS 10_1101-2021_01_04_425177 155 12 Disease Disease NNP 10_1101-2021_01_04_425177 155 13 and and CC 10_1101-2021_01_04_425177 155 14 Insulin Insulin NNP 10_1101-2021_01_04_425177 155 15 Linked link VBN 10_1101-2021_01_04_425177 155 16 to to IN 10_1101-2021_01_04_425177 155 17 Diabetes Diabetes NNP 10_1101-2021_01_04_425177 155 18 Mellitus Mellitus NNP 10_1101-2021_01_04_425177 155 19 Type Type NNP 10_1101-2021_01_04_425177 155 20 II II NNP 10_1101-2021_01_04_425177 155 21 . . . 10_1101-2021_01_04_425177 156 1 ACS ACS NNP 10_1101-2021_01_04_425177 156 2 Chem Chem NNP 10_1101-2021_01_04_425177 156 3 Neurosci Neurosci NNP 10_1101-2021_01_04_425177 156 4 7 7 CD 10_1101-2021_01_04_425177 156 5 , , , 10_1101-2021_01_04_425177 156 6 269 269 CD 10_1101-2021_01_04_425177 156 7 - - SYM 10_1101-2021_01_04_425177 156 8 274 274 CD 10_1101-2021_01_04_425177 156 9 . . . 10_1101-2021_01_04_425177 157 1 Luo Luo NNP 10_1101-2021_01_04_425177 157 2 , , , 10_1101-2021_01_04_425177 157 3 J. J. NNP 10_1101-2021_01_04_425177 157 4 , , , 10_1101-2021_01_04_425177 157 5 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 157 6 , , , 10_1101-2021_01_04_425177 157 7 S.K. S.K. NNP 10_1101-2021_01_04_425177 157 8 , , , 10_1101-2021_01_04_425177 157 9 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 157 10 , , , 10_1101-2021_01_04_425177 157 11 A. a. NN 10_1101-2021_01_04_425177 157 12 , , , 10_1101-2021_01_04_425177 157 13 Abrahams Abrahams NNP 10_1101-2021_01_04_425177 157 14 , , , 10_1101-2021_01_04_425177 157 15 J.P. J.P. NNP 10_1101-2021_01_04_425177 157 16 , , , 10_1101-2021_01_04_425177 157 17 2017 2017 CD 10_1101-2021_01_04_425177 157 18 . . . 10_1101-2021_01_04_425177 158 1 Cross cross NN 10_1101-2021_01_04_425177 158 2 - - NNS 10_1101-2021_01_04_425177 158 3 interactions interaction NNS 10_1101-2021_01_04_425177 158 4 between between IN 10_1101-2021_01_04_425177 158 5 the the DT 10_1101-2021_01_04_425177 158 6 Alzheimer Alzheimer NNP 10_1101-2021_01_04_425177 158 7 disease disease NN 10_1101-2021_01_04_425177 158 8 amyloid amyloid NN 10_1101-2021_01_04_425177 158 9 - - HYPH 10_1101-2021_01_04_425177 158 10 beta beta NN 10_1101-2021_01_04_425177 158 11 peptide peptide NN 10_1101-2021_01_04_425177 158 12 and and CC 10_1101-2021_01_04_425177 158 13 other other JJ 10_1101-2021_01_04_425177 158 14 amyloid amyloid NN 10_1101-2021_01_04_425177 158 15 proteins protein NNS 10_1101-2021_01_04_425177 158 16 . . . 10_1101-2021_01_04_425177 159 1 A a DT 10_1101-2021_01_04_425177 159 2 FURTHER further JJ 10_1101-2021_01_04_425177 159 3 ASPECT ASPECT NNS 10_1101-2021_01_04_425177 159 4 OF of IN 10_1101-2021_01_04_425177 159 5 THE the DT 10_1101-2021_01_04_425177 159 6 AMYLOID amyloid JJ 10_1101-2021_01_04_425177 159 7 CASCADE cascade NN 10_1101-2021_01_04_425177 159 8 HYPOTHESIS hypothesi NNS 10_1101-2021_01_04_425177 159 9 . . . 10_1101-2021_01_04_425177 160 1 J J NNP 10_1101-2021_01_04_425177 160 2 Biol Biol NNP 10_1101-2021_01_04_425177 160 3 Chem Chem NNP 10_1101-2021_01_04_425177 160 4 292 292 CD 10_1101-2021_01_04_425177 160 5 , , , 10_1101-2021_01_04_425177 160 6 2046 2046 CD 10_1101-2021_01_04_425177 160 7 . . . 10_1101-2021_01_04_425177 161 1 Löfgren Löfgren NNP 10_1101-2021_01_04_425177 161 2 , , , 10_1101-2021_01_04_425177 161 3 K. K. NNP 10_1101-2021_01_04_425177 161 4 , , , 10_1101-2021_01_04_425177 161 5 Wahlström Wahlström NNP 10_1101-2021_01_04_425177 161 6 , , , 10_1101-2021_01_04_425177 161 7 A. A. NNP 10_1101-2021_01_04_425177 161 8 , , , 10_1101-2021_01_04_425177 161 9 Lundberg Lundberg NNP 10_1101-2021_01_04_425177 161 10 , , , 10_1101-2021_01_04_425177 161 11 P. P. NNP 10_1101-2021_01_04_425177 161 12 , , , 10_1101-2021_01_04_425177 161 13 Langel Langel NNP 10_1101-2021_01_04_425177 161 14 , , , 10_1101-2021_01_04_425177 161 15 U. U. NNP 10_1101-2021_01_04_425177 161 16 , , , 10_1101-2021_01_04_425177 161 17 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 161 18 , , , 10_1101-2021_01_04_425177 161 19 A. a. NN 10_1101-2021_01_04_425177 161 20 , , , 10_1101-2021_01_04_425177 161 21 Bedecs Bedecs NNP 10_1101-2021_01_04_425177 161 22 , , , 10_1101-2021_01_04_425177 161 23 K. K. NNP 10_1101-2021_01_04_425177 161 24 , , , 10_1101-2021_01_04_425177 161 25 2008 2008 CD 10_1101-2021_01_04_425177 161 26 . . . 10_1101-2021_01_04_425177 162 1 Antiprion antiprion NN 10_1101-2021_01_04_425177 162 2 properties property NNS 10_1101-2021_01_04_425177 162 3 of of IN 10_1101-2021_01_04_425177 162 4 prion prion NN 10_1101-2021_01_04_425177 162 5 protein protein NN 10_1101-2021_01_04_425177 162 6 - - HYPH 10_1101-2021_01_04_425177 162 7 derived derive VBN 10_1101-2021_01_04_425177 162 8 cell cell NN 10_1101-2021_01_04_425177 162 9 - - HYPH 10_1101-2021_01_04_425177 162 10 penetrating penetrating NN 10_1101-2021_01_04_425177 162 11 peptides peptide NNS 10_1101-2021_01_04_425177 162 12 . . . 10_1101-2021_01_04_425177 163 1 FASEB FASEB NNP 10_1101-2021_01_04_425177 163 2 J J NNP 10_1101-2021_01_04_425177 163 3 22 22 CD 10_1101-2021_01_04_425177 163 4 , , , 10_1101-2021_01_04_425177 163 5 2177 2177 CD 10_1101-2021_01_04_425177 163 6 - - SYM 10_1101-2021_01_04_425177 163 7 2184 2184 CD 10_1101-2021_01_04_425177 163 8 . . . 10_1101-2021_01_04_425177 164 1 .CC .CC NFP 10_1101-2021_01_04_425177 164 2 - - : 10_1101-2021_01_04_425177 164 3 BY by IN 10_1101-2021_01_04_425177 164 4 - - HYPH 10_1101-2021_01_04_425177 164 5 NC NC NNP 10_1101-2021_01_04_425177 164 6 - - HYPH 10_1101-2021_01_04_425177 164 7 ND ND NNP 10_1101-2021_01_04_425177 164 8 4.0 4.0 CD 10_1101-2021_01_04_425177 164 9 International international JJ 10_1101-2021_01_04_425177 164 10 licensemade licensemade NN 10_1101-2021_01_04_425177 164 11 available available JJ 10_1101-2021_01_04_425177 164 12 under under IN 10_1101-2021_01_04_425177 164 13 a a DT 10_1101-2021_01_04_425177 164 14 ( ( -LRB- 10_1101-2021_01_04_425177 164 15 which which WDT 10_1101-2021_01_04_425177 164 16 was be VBD 10_1101-2021_01_04_425177 164 17 not not RB 10_1101-2021_01_04_425177 164 18 certified certify VBN 10_1101-2021_01_04_425177 164 19 by by IN 10_1101-2021_01_04_425177 164 20 peer peer NN 10_1101-2021_01_04_425177 164 21 review review NN 10_1101-2021_01_04_425177 164 22 ) ) -RRB- 10_1101-2021_01_04_425177 164 23 is be VBZ 10_1101-2021_01_04_425177 164 24 the the DT 10_1101-2021_01_04_425177 164 25 author author NN 10_1101-2021_01_04_425177 164 26 / / SYM 10_1101-2021_01_04_425177 164 27 funder funder NN 10_1101-2021_01_04_425177 164 28 , , , 10_1101-2021_01_04_425177 164 29 who who WP 10_1101-2021_01_04_425177 164 30 has have VBZ 10_1101-2021_01_04_425177 164 31 granted grant VBN 10_1101-2021_01_04_425177 164 32 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 164 33 a a DT 10_1101-2021_01_04_425177 164 34 license license NN 10_1101-2021_01_04_425177 164 35 to to TO 10_1101-2021_01_04_425177 164 36 display display VB 10_1101-2021_01_04_425177 164 37 the the DT 10_1101-2021_01_04_425177 164 38 preprint preprint NN 10_1101-2021_01_04_425177 164 39 in in IN 10_1101-2021_01_04_425177 164 40 perpetuity perpetuity NN 10_1101-2021_01_04_425177 164 41 . . . 10_1101-2021_01_04_425177 165 1 It -PRON- PRP 10_1101-2021_01_04_425177 165 2 is be VBZ 10_1101-2021_01_04_425177 165 3 The the DT 10_1101-2021_01_04_425177 165 4 copyright copyright NN 10_1101-2021_01_04_425177 165 5 holder holder NN 10_1101-2021_01_04_425177 165 6 for for IN 10_1101-2021_01_04_425177 165 7 this this DT 10_1101-2021_01_04_425177 165 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 165 9 version version NN 10_1101-2021_01_04_425177 165 10 posted post VBD 10_1101-2021_01_04_425177 165 11 January January NNP 10_1101-2021_01_04_425177 165 12 4 4 CD 10_1101-2021_01_04_425177 165 13 , , , 10_1101-2021_01_04_425177 165 14 2021 2021 CD 10_1101-2021_01_04_425177 165 15 . . . 10_1101-2021_01_04_425177 165 16 ; ; : 10_1101-2021_01_04_425177 165 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 165 18 : : : 10_1101-2021_01_04_425177 165 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 165 20 preprint preprint NN 10_1101-2021_01_04_425177 165 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 VBZ 10_1101-2021_01_04_425177 165 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_04_425177 165 23 11 11 CD 10_1101-2021_01_04_425177 165 24 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 165 25 , , , 10_1101-2021_01_04_425177 165 26 M. M. NNP 10_1101-2021_01_04_425177 165 27 , , , 10_1101-2021_01_04_425177 165 28 Oglecka Oglecka NNP 10_1101-2021_01_04_425177 165 29 , , , 10_1101-2021_01_04_425177 165 30 K. K. NNP 10_1101-2021_01_04_425177 165 31 , , , 10_1101-2021_01_04_425177 165 32 Pramanik Pramanik NNP 10_1101-2021_01_04_425177 165 33 , , , 10_1101-2021_01_04_425177 165 34 A. A. NNP 10_1101-2021_01_04_425177 165 35 , , , 10_1101-2021_01_04_425177 165 36 Eriksson Eriksson NNP 10_1101-2021_01_04_425177 165 37 , , , 10_1101-2021_01_04_425177 165 38 G.L.E. G.L.E. NNP 10_1101-2021_01_04_425177 165 39 , , , 10_1101-2021_01_04_425177 165 40 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 165 41 , , , 10_1101-2021_01_04_425177 165 42 A. a. NN 10_1101-2021_01_04_425177 165 43 , , , 10_1101-2021_01_04_425177 165 44 2005 2005 CD 10_1101-2021_01_04_425177 165 45 . . . 10_1101-2021_01_04_425177 166 1 Membrane membrane NN 10_1101-2021_01_04_425177 166 2 perturbation perturbation NN 10_1101-2021_01_04_425177 166 3 effects effect NNS 10_1101-2021_01_04_425177 166 4 of of IN 10_1101-2021_01_04_425177 166 5 peptides peptide NNS 10_1101-2021_01_04_425177 166 6 derived derive VBN 10_1101-2021_01_04_425177 166 7 from from IN 10_1101-2021_01_04_425177 166 8 the the DT 10_1101-2021_01_04_425177 166 9 N N NNP 10_1101-2021_01_04_425177 166 10 - - HYPH 10_1101-2021_01_04_425177 166 11 termini termini NN 10_1101-2021_01_04_425177 166 12 of of IN 10_1101-2021_01_04_425177 166 13 unprocessed unprocessed JJ 10_1101-2021_01_04_425177 166 14 prion prion NN 10_1101-2021_01_04_425177 166 15 proteins protein NNS 10_1101-2021_01_04_425177 166 16 . . . 10_1101-2021_01_04_425177 167 1 Biochim Biochim NNP 10_1101-2021_01_04_425177 167 2 Biophys Biophys NNP 10_1101-2021_01_04_425177 167 3 Acta Acta NNP 10_1101-2021_01_04_425177 167 4 1716 1716 CD 10_1101-2021_01_04_425177 167 5 , , , 10_1101-2021_01_04_425177 167 6 126 126 CD 10_1101-2021_01_04_425177 167 7 - - SYM 10_1101-2021_01_04_425177 167 8 136 136 CD 10_1101-2021_01_04_425177 167 9 . . . 10_1101-2021_01_04_425177 168 1 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 168 2 , , , 10_1101-2021_01_04_425177 168 3 M. M. NNP 10_1101-2021_01_04_425177 168 4 , , , 10_1101-2021_01_04_425177 168 5 Sandgren Sandgren NNP 10_1101-2021_01_04_425177 168 6 , , , 10_1101-2021_01_04_425177 168 7 S. S. NNP 10_1101-2021_01_04_425177 168 8 , , , 10_1101-2021_01_04_425177 168 9 Lundberg Lundberg NNP 10_1101-2021_01_04_425177 168 10 , , , 10_1101-2021_01_04_425177 168 11 P. P. NNP 10_1101-2021_01_04_425177 168 12 , , , 10_1101-2021_01_04_425177 168 13 Oglecka Oglecka NNP 10_1101-2021_01_04_425177 168 14 , , , 10_1101-2021_01_04_425177 168 15 K. K. NNP 10_1101-2021_01_04_425177 168 16 , , , 10_1101-2021_01_04_425177 168 17 Lilja Lilja NNP 10_1101-2021_01_04_425177 168 18 , , , 10_1101-2021_01_04_425177 168 19 J. J. NNP 10_1101-2021_01_04_425177 168 20 , , , 10_1101-2021_01_04_425177 168 21 Wittrup Wittrup NNP 10_1101-2021_01_04_425177 168 22 , , , 10_1101-2021_01_04_425177 168 23 A. a. NN 10_1101-2021_01_04_425177 168 24 , , , 10_1101-2021_01_04_425177 168 25 Eriksson Eriksson NNP 10_1101-2021_01_04_425177 168 26 , , , 10_1101-2021_01_04_425177 168 27 G.L.E. G.L.E. NNP 10_1101-2021_01_04_425177 168 28 , , , 10_1101-2021_01_04_425177 168 29 Langel Langel NNP 10_1101-2021_01_04_425177 168 30 , , , 10_1101-2021_01_04_425177 168 31 U. U. NNP 10_1101-2021_01_04_425177 168 32 , , , 10_1101-2021_01_04_425177 168 33 Belting Belting NNP 10_1101-2021_01_04_425177 168 34 , , , 10_1101-2021_01_04_425177 168 35 M. M. NNP 10_1101-2021_01_04_425177 168 36 , , , 10_1101-2021_01_04_425177 168 37 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 168 38 , , , 10_1101-2021_01_04_425177 168 39 A. a. NN 10_1101-2021_01_04_425177 168 40 , , , 10_1101-2021_01_04_425177 168 41 2006 2006 CD 10_1101-2021_01_04_425177 168 42 . . . 10_1101-2021_01_04_425177 169 1 N n CD 10_1101-2021_01_04_425177 169 2 - - HYPH 10_1101-2021_01_04_425177 169 3 terminal terminal NN 10_1101-2021_01_04_425177 169 4 peptides peptide NNS 10_1101-2021_01_04_425177 169 5 from from IN 10_1101-2021_01_04_425177 169 6 unprocessed unprocessed JJ 10_1101-2021_01_04_425177 169 7 prion prion NN 10_1101-2021_01_04_425177 169 8 proteins protein NNS 10_1101-2021_01_04_425177 169 9 enter enter VBP 10_1101-2021_01_04_425177 169 10 cells cell NNS 10_1101-2021_01_04_425177 169 11 by by IN 10_1101-2021_01_04_425177 169 12 macropinocytosis macropinocytosis NN 10_1101-2021_01_04_425177 169 13 . . . 10_1101-2021_01_04_425177 170 1 Biochem Biochem NNP 10_1101-2021_01_04_425177 170 2 Biophys Biophys NNP 10_1101-2021_01_04_425177 170 3 Res Res NNP 10_1101-2021_01_04_425177 170 4 Commun Commun NNP 10_1101-2021_01_04_425177 170 5 348 348 CD 10_1101-2021_01_04_425177 170 6 , , , 10_1101-2021_01_04_425177 170 7 379 379 CD 10_1101-2021_01_04_425177 170 8 - - SYM 10_1101-2021_01_04_425177 170 9 385 385 CD 10_1101-2021_01_04_425177 170 10 . . . 10_1101-2021_01_04_425177 171 1 Mashima Mashima NNP 10_1101-2021_01_04_425177 171 2 , , , 10_1101-2021_01_04_425177 171 3 T. T. NNP 10_1101-2021_01_04_425177 171 4 , , , 10_1101-2021_01_04_425177 171 5 Lee Lee NNP 10_1101-2021_01_04_425177 171 6 , , , 10_1101-2021_01_04_425177 171 7 J.H. J.H. NNP 10_1101-2021_01_04_425177 171 8 , , , 10_1101-2021_01_04_425177 171 9 Kamatari Kamatari NNP 10_1101-2021_01_04_425177 171 10 , , , 10_1101-2021_01_04_425177 171 11 Y.O. Y.O. NNP 10_1101-2021_01_04_425177 171 12 , , , 10_1101-2021_01_04_425177 171 13 Hayashi Hayashi NNP 10_1101-2021_01_04_425177 171 14 , , , 10_1101-2021_01_04_425177 171 15 T. T. NNP 10_1101-2021_01_04_425177 171 16 , , , 10_1101-2021_01_04_425177 171 17 Nagata Nagata NNP 10_1101-2021_01_04_425177 171 18 , , , 10_1101-2021_01_04_425177 171 19 T. T. NNP 10_1101-2021_01_04_425177 171 20 , , , 10_1101-2021_01_04_425177 171 21 Nishikawa Nishikawa NNP 10_1101-2021_01_04_425177 171 22 , , , 10_1101-2021_01_04_425177 171 23 F. F. NNP 10_1101-2021_01_04_425177 171 24 , , , 10_1101-2021_01_04_425177 171 25 Nishikawa Nishikawa NNP 10_1101-2021_01_04_425177 171 26 , , , 10_1101-2021_01_04_425177 171 27 S. S. NNP 10_1101-2021_01_04_425177 171 28 , , , 10_1101-2021_01_04_425177 171 29 Kinoshita Kinoshita NNP 10_1101-2021_01_04_425177 171 30 , , , 10_1101-2021_01_04_425177 171 31 M. M. NNP 10_1101-2021_01_04_425177 171 32 , , , 10_1101-2021_01_04_425177 171 33 Kuwata Kuwata NNP 10_1101-2021_01_04_425177 171 34 , , , 10_1101-2021_01_04_425177 171 35 K. K. NNP 10_1101-2021_01_04_425177 171 36 , , , 10_1101-2021_01_04_425177 171 37 Katahira Katahira NNP 10_1101-2021_01_04_425177 171 38 , , , 10_1101-2021_01_04_425177 171 39 M. M. NNP 10_1101-2021_01_04_425177 171 40 , , , 10_1101-2021_01_04_425177 171 41 2020 2020 CD 10_1101-2021_01_04_425177 171 42 . . . 10_1101-2021_01_04_425177 172 1 Development development NN 10_1101-2021_01_04_425177 172 2 and and CC 10_1101-2021_01_04_425177 172 3 structural structural JJ 10_1101-2021_01_04_425177 172 4 determination determination NN 10_1101-2021_01_04_425177 172 5 of of IN 10_1101-2021_01_04_425177 172 6 an an DT 10_1101-2021_01_04_425177 172 7 anti- anti- NN 10_1101-2021_01_04_425177 172 8 PrP(C PrP(C NNP 10_1101-2021_01_04_425177 172 9 ) ) -RRB- 10_1101-2021_01_04_425177 172 10 aptamer aptamer NN 10_1101-2021_01_04_425177 172 11 that that WDT 10_1101-2021_01_04_425177 172 12 blocks block VBZ 10_1101-2021_01_04_425177 172 13 pathological pathological JJ 10_1101-2021_01_04_425177 172 14 conformational conformational JJ 10_1101-2021_01_04_425177 172 15 conversion conversion NN 10_1101-2021_01_04_425177 172 16 of of IN 10_1101-2021_01_04_425177 172 17 prion prion NN 10_1101-2021_01_04_425177 172 18 protein protein NN 10_1101-2021_01_04_425177 172 19 . . . 10_1101-2021_01_04_425177 173 1 Sci Sci NNP 10_1101-2021_01_04_425177 173 2 Rep Rep NNP 10_1101-2021_01_04_425177 173 3 10 10 CD 10_1101-2021_01_04_425177 173 4 , , , 10_1101-2021_01_04_425177 173 5 4934 4934 CD 10_1101-2021_01_04_425177 173 6 . . . 10_1101-2021_01_04_425177 174 1 Miller Miller NNP 10_1101-2021_01_04_425177 174 2 , , , 10_1101-2021_01_04_425177 174 3 G. G. NNP 10_1101-2021_01_04_425177 174 4 , , , 10_1101-2021_01_04_425177 174 5 2009 2009 CD 10_1101-2021_01_04_425177 174 6 . . . 10_1101-2021_01_04_425177 175 1 Neurodegeneration neurodegeneration NN 10_1101-2021_01_04_425177 175 2 . . . 10_1101-2021_01_04_425177 176 1 Could Could MD 10_1101-2021_01_04_425177 176 2 they -PRON- PRP 10_1101-2021_01_04_425177 176 3 all all DT 10_1101-2021_01_04_425177 176 4 be be VB 10_1101-2021_01_04_425177 176 5 prion prion NN 10_1101-2021_01_04_425177 176 6 diseases disease NNS 10_1101-2021_01_04_425177 176 7 ? ? . 10_1101-2021_01_04_425177 177 1 Science science NN 10_1101-2021_01_04_425177 177 2 326 326 CD 10_1101-2021_01_04_425177 177 3 , , , 10_1101-2021_01_04_425177 177 4 1337 1337 CD 10_1101-2021_01_04_425177 177 5 - - SYM 10_1101-2021_01_04_425177 177 6 1339 1339 CD 10_1101-2021_01_04_425177 177 7 . . . 10_1101-2021_01_04_425177 178 1 Morillas Morillas NNP 10_1101-2021_01_04_425177 178 2 , , , 10_1101-2021_01_04_425177 178 3 M. M. NNP 10_1101-2021_01_04_425177 178 4 , , , 10_1101-2021_01_04_425177 178 5 Swietnicki Swietnicki NNP 10_1101-2021_01_04_425177 178 6 , , , 10_1101-2021_01_04_425177 178 7 W. W. NNP 10_1101-2021_01_04_425177 178 8 , , , 10_1101-2021_01_04_425177 178 9 Gambetti Gambetti NNP 10_1101-2021_01_04_425177 178 10 , , , 10_1101-2021_01_04_425177 178 11 P. P. NNP 10_1101-2021_01_04_425177 178 12 , , , 10_1101-2021_01_04_425177 178 13 Surewicz Surewicz NNP 10_1101-2021_01_04_425177 178 14 , , , 10_1101-2021_01_04_425177 178 15 W.K. W.K. NNP 10_1101-2021_01_04_425177 178 16 , , , 10_1101-2021_01_04_425177 178 17 1999 1999 CD 10_1101-2021_01_04_425177 178 18 . . . 10_1101-2021_01_04_425177 179 1 Membrane membrane NN 10_1101-2021_01_04_425177 179 2 environment environment NN 10_1101-2021_01_04_425177 179 3 alters alter VBZ 10_1101-2021_01_04_425177 179 4 the the DT 10_1101-2021_01_04_425177 179 5 conformational conformational JJ 10_1101-2021_01_04_425177 179 6 structure structure NN 10_1101-2021_01_04_425177 179 7 of of IN 10_1101-2021_01_04_425177 179 8 the the DT 10_1101-2021_01_04_425177 179 9 recombinant recombinant JJ 10_1101-2021_01_04_425177 179 10 human human JJ 10_1101-2021_01_04_425177 179 11 prion prion NN 10_1101-2021_01_04_425177 179 12 protein protein NN 10_1101-2021_01_04_425177 179 13 . . . 10_1101-2021_01_04_425177 180 1 J J NNP 10_1101-2021_01_04_425177 180 2 Biol Biol NNP 10_1101-2021_01_04_425177 180 3 Chem Chem NNP 10_1101-2021_01_04_425177 180 4 274 274 CD 10_1101-2021_01_04_425177 180 5 , , , 10_1101-2021_01_04_425177 180 6 36859- 36859- CD 10_1101-2021_01_04_425177 180 7 36865 36865 CD 10_1101-2021_01_04_425177 180 8 . . . 10_1101-2021_01_04_425177 181 1 Mukundan Mukundan NNP 10_1101-2021_01_04_425177 181 2 , , , 10_1101-2021_01_04_425177 181 3 V. V. NNP 10_1101-2021_01_04_425177 181 4 , , , 10_1101-2021_01_04_425177 181 5 Maksoudian Maksoudian NNP 10_1101-2021_01_04_425177 181 6 , , , 10_1101-2021_01_04_425177 181 7 C. C. NNP 10_1101-2021_01_04_425177 181 8 , , , 10_1101-2021_01_04_425177 181 9 Vogel Vogel NNP 10_1101-2021_01_04_425177 181 10 , , , 10_1101-2021_01_04_425177 181 11 M.C. M.C. NNP 10_1101-2021_01_04_425177 181 12 , , , 10_1101-2021_01_04_425177 181 13 Chehade Chehade NNP 10_1101-2021_01_04_425177 181 14 , , , 10_1101-2021_01_04_425177 181 15 I. I. NNP 10_1101-2021_01_04_425177 181 16 , , , 10_1101-2021_01_04_425177 181 17 Katsiotis Katsiotis NNP 10_1101-2021_01_04_425177 181 18 , , , 10_1101-2021_01_04_425177 181 19 M.S. M.S. NNP 10_1101-2021_01_04_425177 181 20 , , , 10_1101-2021_01_04_425177 181 21 Alhassan Alhassan NNP 10_1101-2021_01_04_425177 181 22 , , , 10_1101-2021_01_04_425177 181 23 S.M. S.M. NNP 10_1101-2021_01_04_425177 181 24 , , , 10_1101-2021_01_04_425177 181 25 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 181 26 , , , 10_1101-2021_01_04_425177 181 27 M. M. NNP 10_1101-2021_01_04_425177 181 28 , , , 10_1101-2021_01_04_425177 181 29 2017 2017 CD 10_1101-2021_01_04_425177 181 30 . . . 10_1101-2021_01_04_425177 182 1 Cytotoxicity cytotoxicity NN 10_1101-2021_01_04_425177 182 2 of of IN 10_1101-2021_01_04_425177 182 3 prion prion NN 10_1101-2021_01_04_425177 182 4 protein protein NN 10_1101-2021_01_04_425177 182 5 - - HYPH 10_1101-2021_01_04_425177 182 6 derived derive VBN 10_1101-2021_01_04_425177 182 7 cell cell NN 10_1101-2021_01_04_425177 182 8 - - HYPH 10_1101-2021_01_04_425177 182 9 penetrating penetrating NN 10_1101-2021_01_04_425177 182 10 peptides peptide NNS 10_1101-2021_01_04_425177 182 11 is be VBZ 10_1101-2021_01_04_425177 182 12 modulated modulate VBN 10_1101-2021_01_04_425177 182 13 by by IN 10_1101-2021_01_04_425177 182 14 pH pH NNP 10_1101-2021_01_04_425177 182 15 but but CC 10_1101-2021_01_04_425177 182 16 independent independent JJ 10_1101-2021_01_04_425177 182 17 of of IN 10_1101-2021_01_04_425177 182 18 amyloid amyloid NN 10_1101-2021_01_04_425177 182 19 formation formation NN 10_1101-2021_01_04_425177 182 20 . . . 10_1101-2021_01_04_425177 183 1 Arch Arch NNP 10_1101-2021_01_04_425177 183 2 Biochem Biochem NNP 10_1101-2021_01_04_425177 183 3 Biophys Biophys NNP 10_1101-2021_01_04_425177 183 4 613 613 CD 10_1101-2021_01_04_425177 183 5 , , , 10_1101-2021_01_04_425177 183 6 31 31 CD 10_1101-2021_01_04_425177 183 7 - - SYM 10_1101-2021_01_04_425177 183 8 42 42 CD 10_1101-2021_01_04_425177 183 9 . . . 10_1101-2021_01_04_425177 184 1 Necas Necas NNP 10_1101-2021_01_04_425177 184 2 , , , 10_1101-2021_01_04_425177 184 3 D. D. NNP 10_1101-2021_01_04_425177 184 4 , , , 10_1101-2021_01_04_425177 184 5 Klapetek Klapetek NNP 10_1101-2021_01_04_425177 184 6 , , , 10_1101-2021_01_04_425177 184 7 P. P. NNP 10_1101-2021_01_04_425177 184 8 , , , 10_1101-2021_01_04_425177 184 9 2012 2012 CD 10_1101-2021_01_04_425177 184 10 . . . 10_1101-2021_01_04_425177 185 1 Gwyddion gwyddion NN 10_1101-2021_01_04_425177 185 2 : : : 10_1101-2021_01_04_425177 185 3 an an DT 10_1101-2021_01_04_425177 185 4 open open JJ 10_1101-2021_01_04_425177 185 5 - - HYPH 10_1101-2021_01_04_425177 185 6 source source NN 10_1101-2021_01_04_425177 185 7 software software NN 10_1101-2021_01_04_425177 185 8 for for IN 10_1101-2021_01_04_425177 185 9 SPM SPM NNP 10_1101-2021_01_04_425177 185 10 data data NN 10_1101-2021_01_04_425177 185 11 analysis analysis NN 10_1101-2021_01_04_425177 185 12 . . . 10_1101-2021_01_04_425177 186 1 Central central JJ 10_1101-2021_01_04_425177 186 2 European European NNP 10_1101-2021_01_04_425177 186 3 Journal Journal NNP 10_1101-2021_01_04_425177 186 4 of of IN 10_1101-2021_01_04_425177 186 5 Physics Physics NNP 10_1101-2021_01_04_425177 186 6 10 10 CD 10_1101-2021_01_04_425177 186 7 , , , 10_1101-2021_01_04_425177 186 8 181 181 CD 10_1101-2021_01_04_425177 186 9 - - SYM 10_1101-2021_01_04_425177 186 10 188 188 CD 10_1101-2021_01_04_425177 186 11 . . . 10_1101-2021_01_04_425177 187 1 Oglecka Oglecka NNP 10_1101-2021_01_04_425177 187 2 , , , 10_1101-2021_01_04_425177 187 3 K. K. NNP 10_1101-2021_01_04_425177 187 4 , , , 10_1101-2021_01_04_425177 187 5 Lundberg Lundberg NNP 10_1101-2021_01_04_425177 187 6 , , , 10_1101-2021_01_04_425177 187 7 P. P. NNP 10_1101-2021_01_04_425177 187 8 , , , 10_1101-2021_01_04_425177 187 9 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 187 10 , , , 10_1101-2021_01_04_425177 187 11 M. M. NNP 10_1101-2021_01_04_425177 187 12 , , , 10_1101-2021_01_04_425177 187 13 Eriksson Eriksson NNP 10_1101-2021_01_04_425177 187 14 , , , 10_1101-2021_01_04_425177 187 15 G.L.E. G.L.E. NNP 10_1101-2021_01_04_425177 187 16 , , , 10_1101-2021_01_04_425177 187 17 Langel Langel NNP 10_1101-2021_01_04_425177 187 18 , , , 10_1101-2021_01_04_425177 187 19 U. U. NNP 10_1101-2021_01_04_425177 187 20 , , , 10_1101-2021_01_04_425177 187 21 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 187 22 , , , 10_1101-2021_01_04_425177 187 23 A. a. NN 10_1101-2021_01_04_425177 187 24 , , , 10_1101-2021_01_04_425177 187 25 2008 2008 CD 10_1101-2021_01_04_425177 187 26 . . . 10_1101-2021_01_04_425177 188 1 Relevance relevance NN 10_1101-2021_01_04_425177 188 2 of of IN 10_1101-2021_01_04_425177 188 3 the the DT 10_1101-2021_01_04_425177 188 4 N n NN 10_1101-2021_01_04_425177 188 5 - - HYPH 10_1101-2021_01_04_425177 188 6 terminal terminal JJ 10_1101-2021_01_04_425177 188 7 NLS NLS NNP 10_1101-2021_01_04_425177 188 8 - - HYPH 10_1101-2021_01_04_425177 188 9 like like JJ 10_1101-2021_01_04_425177 188 10 sequence sequence NN 10_1101-2021_01_04_425177 188 11 of of IN 10_1101-2021_01_04_425177 188 12 the the DT 10_1101-2021_01_04_425177 188 13 prion prion NN 10_1101-2021_01_04_425177 188 14 protein protein NN 10_1101-2021_01_04_425177 188 15 for for IN 10_1101-2021_01_04_425177 188 16 membrane membrane NN 10_1101-2021_01_04_425177 188 17 perturbation perturbation NN 10_1101-2021_01_04_425177 188 18 effects effect NNS 10_1101-2021_01_04_425177 188 19 . . . 10_1101-2021_01_04_425177 189 1 Biochim Biochim NNP 10_1101-2021_01_04_425177 189 2 Biophys Biophys NNP 10_1101-2021_01_04_425177 189 3 Acta Acta NNP 10_1101-2021_01_04_425177 189 4 1778 1778 CD 10_1101-2021_01_04_425177 189 5 , , , 10_1101-2021_01_04_425177 189 6 206 206 CD 10_1101-2021_01_04_425177 189 7 - - SYM 10_1101-2021_01_04_425177 189 8 213 213 CD 10_1101-2021_01_04_425177 189 9 . . . 10_1101-2021_01_04_425177 190 1 Owen Owen NNP 10_1101-2021_01_04_425177 190 2 , , , 10_1101-2021_01_04_425177 190 3 M.C. M.C. NNP 10_1101-2021_01_04_425177 190 4 , , , 10_1101-2021_01_04_425177 190 5 Gnutt Gnutt NNP 10_1101-2021_01_04_425177 190 6 , , , 10_1101-2021_01_04_425177 190 7 D. D. NNP 10_1101-2021_01_04_425177 190 8 , , , 10_1101-2021_01_04_425177 190 9 Gao Gao NNP 10_1101-2021_01_04_425177 190 10 , , , 10_1101-2021_01_04_425177 190 11 M. M. NNP 10_1101-2021_01_04_425177 190 12 , , , 10_1101-2021_01_04_425177 190 13 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 190 14 , , , 10_1101-2021_01_04_425177 190 15 S.K.T.S. S.K.T.S. NNP 10_1101-2021_01_04_425177 190 16 , , , 10_1101-2021_01_04_425177 190 17 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 190 18 , , , 10_1101-2021_01_04_425177 190 19 J. J. NNP 10_1101-2021_01_04_425177 190 20 , , , 10_1101-2021_01_04_425177 190 21 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 190 22 , , , 10_1101-2021_01_04_425177 190 23 A. A. NNP 10_1101-2021_01_04_425177 190 24 , , , 10_1101-2021_01_04_425177 190 25 Winter Winter NNP 10_1101-2021_01_04_425177 190 26 , , , 10_1101-2021_01_04_425177 190 27 R. R. NNP 10_1101-2021_01_04_425177 190 28 , , , 10_1101-2021_01_04_425177 190 29 Ebbinghaus Ebbinghaus NNP 10_1101-2021_01_04_425177 190 30 , , , 10_1101-2021_01_04_425177 190 31 S. S. NNP 10_1101-2021_01_04_425177 190 32 , , , 10_1101-2021_01_04_425177 190 33 Strodel Strodel NNP 10_1101-2021_01_04_425177 190 34 , , , 10_1101-2021_01_04_425177 190 35 B. B. NNP 10_1101-2021_01_04_425177 190 36 , , , 10_1101-2021_01_04_425177 190 37 2019 2019 CD 10_1101-2021_01_04_425177 190 38 . . . 10_1101-2021_01_04_425177 191 1 Effects effect NNS 10_1101-2021_01_04_425177 191 2 of of IN 10_1101-2021_01_04_425177 191 3 in in IN 10_1101-2021_01_04_425177 191 4 vivo vivo NNP 10_1101-2021_01_04_425177 191 5 conditions condition NNS 10_1101-2021_01_04_425177 191 6 on on IN 10_1101-2021_01_04_425177 191 7 amyloid amyloid NN 10_1101-2021_01_04_425177 191 8 aggregation aggregation NN 10_1101-2021_01_04_425177 191 9 . . . 10_1101-2021_01_04_425177 192 1 Chem Chem NNP 10_1101-2021_01_04_425177 192 2 Soc Soc NNP 10_1101-2021_01_04_425177 192 3 Rev Rev NNP 10_1101-2021_01_04_425177 192 4 48 48 CD 10_1101-2021_01_04_425177 192 5 , , , 10_1101-2021_01_04_425177 192 6 3946 3946 CD 10_1101-2021_01_04_425177 192 7 - - SYM 10_1101-2021_01_04_425177 192 8 3996 3996 CD 10_1101-2021_01_04_425177 192 9 . . . 10_1101-2021_01_04_425177 193 1 Pansieri Pansieri NNP 10_1101-2021_01_04_425177 193 2 , , , 10_1101-2021_01_04_425177 193 3 J. J. NNP 10_1101-2021_01_04_425177 193 4 , , , 10_1101-2021_01_04_425177 193 5 Ostojic Ostojic NNP 10_1101-2021_01_04_425177 193 6 , , , 10_1101-2021_01_04_425177 193 7 L. L. NNP 10_1101-2021_01_04_425177 193 8 , , , 10_1101-2021_01_04_425177 193 9 Iashchishyn Iashchishyn NNP 10_1101-2021_01_04_425177 193 10 , , , 10_1101-2021_01_04_425177 193 11 I.A. I.A. NNP 10_1101-2021_01_04_425177 193 12 , , , 10_1101-2021_01_04_425177 193 13 Magzoub Magzoub NNP 10_1101-2021_01_04_425177 193 14 , , , 10_1101-2021_01_04_425177 193 15 M. M. NNP 10_1101-2021_01_04_425177 193 16 , , , 10_1101-2021_01_04_425177 193 17 Wallin Wallin NNP 10_1101-2021_01_04_425177 193 18 , , , 10_1101-2021_01_04_425177 193 19 C. C. NNP 10_1101-2021_01_04_425177 193 20 , , , 10_1101-2021_01_04_425177 193 21 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 193 22 , , , 10_1101-2021_01_04_425177 193 23 S. S. NNP 10_1101-2021_01_04_425177 193 24 , , , 10_1101-2021_01_04_425177 193 25 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 193 26 , , , 10_1101-2021_01_04_425177 193 27 A. A. NNP 10_1101-2021_01_04_425177 193 28 , , , 10_1101-2021_01_04_425177 193 29 Nguyen Nguyen NNP 10_1101-2021_01_04_425177 193 30 Ngoc Ngoc NNP 10_1101-2021_01_04_425177 193 31 , , , 10_1101-2021_01_04_425177 193 32 M. M. NNP 10_1101-2021_01_04_425177 193 33 , , , 10_1101-2021_01_04_425177 193 34 Smirnovas Smirnovas NNP 10_1101-2021_01_04_425177 193 35 , , , 10_1101-2021_01_04_425177 193 36 V. V. NNP 10_1101-2021_01_04_425177 193 37 , , , 10_1101-2021_01_04_425177 193 38 Svedruzic Svedruzic NNP 10_1101-2021_01_04_425177 193 39 , , , 10_1101-2021_01_04_425177 193 40 Z. Z. NNP 10_1101-2021_01_04_425177 193 41 , , , 10_1101-2021_01_04_425177 193 42 Morozova Morozova NNP 10_1101-2021_01_04_425177 193 43 - - HYPH 10_1101-2021_01_04_425177 193 44 Roche Roche NNP 10_1101-2021_01_04_425177 193 45 , , , 10_1101-2021_01_04_425177 193 46 L.A. L.A. NNP 10_1101-2021_01_04_425177 193 47 , , , 10_1101-2021_01_04_425177 193 48 2019 2019 CD 10_1101-2021_01_04_425177 193 49 . . . 10_1101-2021_01_04_425177 194 1 Pro- pro- LS 10_1101-2021_01_04_425177 194 2 Inflammatory inflammatory NN 10_1101-2021_01_04_425177 194 3 S100A9 s100a9 VBP 10_1101-2021_01_04_425177 194 4 Protein Protein NNP 10_1101-2021_01_04_425177 194 5 Aggregation Aggregation NNP 10_1101-2021_01_04_425177 194 6 Promoted promote VBN 10_1101-2021_01_04_425177 194 7 by by IN 10_1101-2021_01_04_425177 194 8 NCAM1 ncam1 CD 10_1101-2021_01_04_425177 194 9 Peptide Peptide NNP 10_1101-2021_01_04_425177 194 10 Constructs Constructs NNPS 10_1101-2021_01_04_425177 194 11 . . . 10_1101-2021_01_04_425177 195 1 ACS ACS NNP 10_1101-2021_01_04_425177 195 2 Chem Chem NNP 10_1101-2021_01_04_425177 195 3 Biol Biol NNP 10_1101-2021_01_04_425177 195 4 14 14 CD 10_1101-2021_01_04_425177 195 5 , , , 10_1101-2021_01_04_425177 195 6 1410 1410 CD 10_1101-2021_01_04_425177 195 7 - - SYM 10_1101-2021_01_04_425177 195 8 1417 1417 CD 10_1101-2021_01_04_425177 195 9 . . . 10_1101-2021_01_04_425177 196 1 Ren Ren NNP 10_1101-2021_01_04_425177 196 2 , , , 10_1101-2021_01_04_425177 196 3 B. B. NNP 10_1101-2021_01_04_425177 196 4 , , , 10_1101-2021_01_04_425177 196 5 Zhang Zhang NNP 10_1101-2021_01_04_425177 196 6 , , , 10_1101-2021_01_04_425177 196 7 Y. Y. NNP 10_1101-2021_01_04_425177 196 8 , , , 10_1101-2021_01_04_425177 196 9 Zhang Zhang NNP 10_1101-2021_01_04_425177 196 10 , , , 10_1101-2021_01_04_425177 196 11 M. M. NNP 10_1101-2021_01_04_425177 196 12 , , , 10_1101-2021_01_04_425177 196 13 Liu Liu NNP 10_1101-2021_01_04_425177 196 14 , , , 10_1101-2021_01_04_425177 196 15 Y. Y. NNP 10_1101-2021_01_04_425177 196 16 , , , 10_1101-2021_01_04_425177 196 17 Zhang Zhang NNP 10_1101-2021_01_04_425177 196 18 , , , 10_1101-2021_01_04_425177 196 19 D. D. NNP 10_1101-2021_01_04_425177 196 20 , , , 10_1101-2021_01_04_425177 196 21 Gong Gong NNP 10_1101-2021_01_04_425177 196 22 , , , 10_1101-2021_01_04_425177 196 23 X. X. NNP 10_1101-2021_01_04_425177 196 24 , , , 10_1101-2021_01_04_425177 196 25 Feng Feng NNP 10_1101-2021_01_04_425177 196 26 , , , 10_1101-2021_01_04_425177 196 27 Z. Z. NNP 10_1101-2021_01_04_425177 196 28 , , , 10_1101-2021_01_04_425177 196 29 Tang Tang NNP 10_1101-2021_01_04_425177 196 30 , , , 10_1101-2021_01_04_425177 196 31 J. J. NNP 10_1101-2021_01_04_425177 196 32 , , , 10_1101-2021_01_04_425177 196 33 Chang Chang NNP 10_1101-2021_01_04_425177 196 34 , , , 10_1101-2021_01_04_425177 196 35 Y. Y. NNP 10_1101-2021_01_04_425177 196 36 , , , 10_1101-2021_01_04_425177 196 37 Zheng Zheng NNP 10_1101-2021_01_04_425177 196 38 , , , 10_1101-2021_01_04_425177 196 39 J. J. NNP 10_1101-2021_01_04_425177 196 40 , , , 10_1101-2021_01_04_425177 196 41 2019 2019 CD 10_1101-2021_01_04_425177 196 42 . . . 10_1101-2021_01_04_425177 197 1 Fundamentals fundamental NNS 10_1101-2021_01_04_425177 197 2 of of IN 10_1101-2021_01_04_425177 197 3 cross cross NN 10_1101-2021_01_04_425177 197 4 - - JJ 10_1101-2021_01_04_425177 197 5 seeding seeding JJ 10_1101-2021_01_04_425177 197 6 of of IN 10_1101-2021_01_04_425177 197 7 amyloid amyloid NN 10_1101-2021_01_04_425177 197 8 proteins protein NNS 10_1101-2021_01_04_425177 197 9 : : : 10_1101-2021_01_04_425177 197 10 an an DT 10_1101-2021_01_04_425177 197 11 introduction introduction NN 10_1101-2021_01_04_425177 197 12 . . . 10_1101-2021_01_04_425177 198 1 J J NNP 10_1101-2021_01_04_425177 198 2 Mater Mater NNP 10_1101-2021_01_04_425177 198 3 Chem Chem NNP 10_1101-2021_01_04_425177 198 4 B B NNP 10_1101-2021_01_04_425177 198 5 7 7 CD 10_1101-2021_01_04_425177 198 6 , , , 10_1101-2021_01_04_425177 198 7 7267 7267 CD 10_1101-2021_01_04_425177 198 8 - - SYM 10_1101-2021_01_04_425177 198 9 7282 7282 CD 10_1101-2021_01_04_425177 198 10 . . . 10_1101-2021_01_04_425177 199 1 Richman Richman NNP 10_1101-2021_01_04_425177 199 2 , , , 10_1101-2021_01_04_425177 199 3 M. M. NNP 10_1101-2021_01_04_425177 199 4 , , , 10_1101-2021_01_04_425177 199 5 Wilk Wilk NNP 10_1101-2021_01_04_425177 199 6 , , , 10_1101-2021_01_04_425177 199 7 S. S. NNP 10_1101-2021_01_04_425177 199 8 , , , 10_1101-2021_01_04_425177 199 9 Chemerovski Chemerovski NNP 10_1101-2021_01_04_425177 199 10 , , , 10_1101-2021_01_04_425177 199 11 M. M. NNP 10_1101-2021_01_04_425177 199 12 , , , 10_1101-2021_01_04_425177 199 13 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 199 14 , , , 10_1101-2021_01_04_425177 199 15 S.K. S.K. NNP 10_1101-2021_01_04_425177 199 16 , , , 10_1101-2021_01_04_425177 199 17 Wahlström Wahlström NNP 10_1101-2021_01_04_425177 199 18 , , , 10_1101-2021_01_04_425177 199 19 A. A. NNP 10_1101-2021_01_04_425177 199 20 , , , 10_1101-2021_01_04_425177 199 21 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 199 22 , , , 10_1101-2021_01_04_425177 199 23 A. a. NN 10_1101-2021_01_04_425177 199 24 , , , 10_1101-2021_01_04_425177 199 25 Rahimipour Rahimipour NNP 10_1101-2021_01_04_425177 199 26 , , , 10_1101-2021_01_04_425177 199 27 S. S. NNP 10_1101-2021_01_04_425177 199 28 , , , 10_1101-2021_01_04_425177 199 29 2013 2013 CD 10_1101-2021_01_04_425177 199 30 . . . 10_1101-2021_01_04_425177 200 1 In in IN 10_1101-2021_01_04_425177 200 2 vitro vitro FW 10_1101-2021_01_04_425177 200 3 and and CC 10_1101-2021_01_04_425177 200 4 mechanistic mechanistic JJ 10_1101-2021_01_04_425177 200 5 studies study NNS 10_1101-2021_01_04_425177 200 6 of of IN 10_1101-2021_01_04_425177 200 7 an an DT 10_1101-2021_01_04_425177 200 8 antiamyloidogenic antiamyloidogenic JJ 10_1101-2021_01_04_425177 200 9 self self NN 10_1101-2021_01_04_425177 200 10 - - HYPH 10_1101-2021_01_04_425177 200 11 assembled assemble VBN 10_1101-2021_01_04_425177 200 12 cyclic cyclic JJ 10_1101-2021_01_04_425177 200 13 D d NN 10_1101-2021_01_04_425177 200 14 , , , 10_1101-2021_01_04_425177 200 15 L- L- NNP 10_1101-2021_01_04_425177 200 16 alpha alpha NN 10_1101-2021_01_04_425177 200 17 - - HYPH 10_1101-2021_01_04_425177 200 18 peptide peptide NN 10_1101-2021_01_04_425177 200 19 architecture architecture NN 10_1101-2021_01_04_425177 200 20 . . . 10_1101-2021_01_04_425177 201 1 J J NNP 10_1101-2021_01_04_425177 201 2 Am Am NNP 10_1101-2021_01_04_425177 201 3 Chem Chem NNP 10_1101-2021_01_04_425177 201 4 Soc Soc NNP 10_1101-2021_01_04_425177 201 5 135 135 CD 10_1101-2021_01_04_425177 201 6 , , , 10_1101-2021_01_04_425177 201 7 3474 3474 CD 10_1101-2021_01_04_425177 201 8 - - SYM 10_1101-2021_01_04_425177 201 9 3484 3484 CD 10_1101-2021_01_04_425177 201 10 . . . 10_1101-2021_01_04_425177 202 1 Robinson Robinson NNP 10_1101-2021_01_04_425177 202 2 , , , 10_1101-2021_01_04_425177 202 3 P.J. P.J. NNP 10_1101-2021_01_04_425177 202 4 , , , 10_1101-2021_01_04_425177 202 5 Pinheiro Pinheiro NNP 10_1101-2021_01_04_425177 202 6 , , , 10_1101-2021_01_04_425177 202 7 T.J. T.J. NNP 10_1101-2021_01_04_425177 202 8 , , , 10_1101-2021_01_04_425177 202 9 2010 2010 CD 10_1101-2021_01_04_425177 202 10 . . . 10_1101-2021_01_04_425177 203 1 Phospholipid phospholipid JJ 10_1101-2021_01_04_425177 203 2 composition composition NN 10_1101-2021_01_04_425177 203 3 of of IN 10_1101-2021_01_04_425177 203 4 membranes membrane NNS 10_1101-2021_01_04_425177 203 5 directs direct VBZ 10_1101-2021_01_04_425177 203 6 prions prion NNS 10_1101-2021_01_04_425177 203 7 down down IN 10_1101-2021_01_04_425177 203 8 alternative alternative JJ 10_1101-2021_01_04_425177 203 9 aggregation aggregation NN 10_1101-2021_01_04_425177 203 10 pathways pathway NNS 10_1101-2021_01_04_425177 203 11 . . . 10_1101-2021_01_04_425177 204 1 Biophys Biophys NNP 10_1101-2021_01_04_425177 204 2 J J NNP 10_1101-2021_01_04_425177 204 3 98 98 CD 10_1101-2021_01_04_425177 204 4 , , , 10_1101-2021_01_04_425177 204 5 1520 1520 CD 10_1101-2021_01_04_425177 204 6 - - SYM 10_1101-2021_01_04_425177 204 7 1528 1528 CD 10_1101-2021_01_04_425177 204 8 . . . 10_1101-2021_01_04_425177 205 1 Santuccione Santuccione NNP 10_1101-2021_01_04_425177 205 2 , , , 10_1101-2021_01_04_425177 205 3 A. a. NN 10_1101-2021_01_04_425177 205 4 , , , 10_1101-2021_01_04_425177 205 5 Sytnyk Sytnyk NNP 10_1101-2021_01_04_425177 205 6 , , , 10_1101-2021_01_04_425177 205 7 V. V. NNP 10_1101-2021_01_04_425177 205 8 , , , 10_1101-2021_01_04_425177 205 9 Leshchyns'ka Leshchyns'ka NNP 10_1101-2021_01_04_425177 205 10 , , , 10_1101-2021_01_04_425177 205 11 I. I. NNP 10_1101-2021_01_04_425177 205 12 , , , 10_1101-2021_01_04_425177 205 13 Schachner Schachner NNP 10_1101-2021_01_04_425177 205 14 , , , 10_1101-2021_01_04_425177 205 15 M. M. NNP 10_1101-2021_01_04_425177 205 16 , , , 10_1101-2021_01_04_425177 205 17 2005 2005 CD 10_1101-2021_01_04_425177 205 18 . . . 10_1101-2021_01_04_425177 206 1 Prion prion NN 10_1101-2021_01_04_425177 206 2 protein protein NN 10_1101-2021_01_04_425177 206 3 recruits recruit VBZ 10_1101-2021_01_04_425177 206 4 its -PRON- PRP$ 10_1101-2021_01_04_425177 206 5 neuronal neuronal JJ 10_1101-2021_01_04_425177 206 6 receptor receptor NN 10_1101-2021_01_04_425177 206 7 NCAM NCAM NNP 10_1101-2021_01_04_425177 206 8 to to IN 10_1101-2021_01_04_425177 206 9 lipid lipid NN 10_1101-2021_01_04_425177 206 10 rafts raft NNS 10_1101-2021_01_04_425177 206 11 to to TO 10_1101-2021_01_04_425177 206 12 activate activate VB 10_1101-2021_01_04_425177 206 13 p59fyn p59fyn NN 10_1101-2021_01_04_425177 206 14 and and CC 10_1101-2021_01_04_425177 206 15 to to TO 10_1101-2021_01_04_425177 206 16 enhance enhance VB 10_1101-2021_01_04_425177 206 17 neurite neurite NN 10_1101-2021_01_04_425177 206 18 outgrowth outgrowth NN 10_1101-2021_01_04_425177 206 19 . . . 10_1101-2021_01_04_425177 207 1 J J NNP 10_1101-2021_01_04_425177 207 2 Cell Cell NNP 10_1101-2021_01_04_425177 207 3 Biol Biol NNP 10_1101-2021_01_04_425177 207 4 169 169 CD 10_1101-2021_01_04_425177 207 5 , , , 10_1101-2021_01_04_425177 207 6 341 341 CD 10_1101-2021_01_04_425177 207 7 - - SYM 10_1101-2021_01_04_425177 207 8 354 354 CD 10_1101-2021_01_04_425177 207 9 . . . 10_1101-2021_01_04_425177 208 1 Schmitt Schmitt NNP 10_1101-2021_01_04_425177 208 2 - - HYPH 10_1101-2021_01_04_425177 208 3 Ulms Ulms NNP 10_1101-2021_01_04_425177 208 4 , , , 10_1101-2021_01_04_425177 208 5 G. G. NNP 10_1101-2021_01_04_425177 208 6 , , , 10_1101-2021_01_04_425177 208 7 Legname Legname NNP 10_1101-2021_01_04_425177 208 8 , , , 10_1101-2021_01_04_425177 208 9 G. G. NNP 10_1101-2021_01_04_425177 208 10 , , , 10_1101-2021_01_04_425177 208 11 Baldwin Baldwin NNP 10_1101-2021_01_04_425177 208 12 , , , 10_1101-2021_01_04_425177 208 13 M.A. M.A. NNP 10_1101-2021_01_04_425177 208 14 , , , 10_1101-2021_01_04_425177 208 15 Ball Ball NNP 10_1101-2021_01_04_425177 208 16 , , , 10_1101-2021_01_04_425177 208 17 H.L. H.L. NNP 10_1101-2021_01_04_425177 208 18 , , , 10_1101-2021_01_04_425177 208 19 Bradon Bradon NNP 10_1101-2021_01_04_425177 208 20 , , , 10_1101-2021_01_04_425177 208 21 N. N. NNP 10_1101-2021_01_04_425177 208 22 , , , 10_1101-2021_01_04_425177 208 23 Bosque Bosque NNP 10_1101-2021_01_04_425177 208 24 , , , 10_1101-2021_01_04_425177 208 25 P.J. P.J. NNP 10_1101-2021_01_04_425177 208 26 , , , 10_1101-2021_01_04_425177 208 27 Crossin Crossin NNP 10_1101-2021_01_04_425177 208 28 , , , 10_1101-2021_01_04_425177 208 29 K.L. K.L. NNP 10_1101-2021_01_04_425177 208 30 , , , 10_1101-2021_01_04_425177 208 31 Edelman Edelman NNP 10_1101-2021_01_04_425177 208 32 , , , 10_1101-2021_01_04_425177 208 33 G.M. G.M. NNP 10_1101-2021_01_04_425177 208 34 , , , 10_1101-2021_01_04_425177 208 35 DeArmond DeArmond NNP 10_1101-2021_01_04_425177 208 36 , , , 10_1101-2021_01_04_425177 208 37 S.J. S.J. NNP 10_1101-2021_01_04_425177 208 38 , , , 10_1101-2021_01_04_425177 208 39 Cohen Cohen NNP 10_1101-2021_01_04_425177 208 40 , , , 10_1101-2021_01_04_425177 208 41 F.E. F.E. NNP 10_1101-2021_01_04_425177 208 42 , , , 10_1101-2021_01_04_425177 208 43 Prusiner Prusiner NNP 10_1101-2021_01_04_425177 208 44 , , , 10_1101-2021_01_04_425177 208 45 S.B. S.B. NNP 10_1101-2021_01_04_425177 208 46 , , , 10_1101-2021_01_04_425177 208 47 2001 2001 CD 10_1101-2021_01_04_425177 208 48 . . . 10_1101-2021_01_04_425177 209 1 Binding bind VBG 10_1101-2021_01_04_425177 209 2 of of IN 10_1101-2021_01_04_425177 209 3 neural neural JJ 10_1101-2021_01_04_425177 209 4 cell cell NN 10_1101-2021_01_04_425177 209 5 adhesion adhesion NN 10_1101-2021_01_04_425177 209 6 molecules molecule NNS 10_1101-2021_01_04_425177 209 7 ( ( -LRB- 10_1101-2021_01_04_425177 209 8 N n NN 10_1101-2021_01_04_425177 209 9 - - HYPH 10_1101-2021_01_04_425177 209 10 CAMs CAMs NNP 10_1101-2021_01_04_425177 209 11 ) ) -RRB- 10_1101-2021_01_04_425177 209 12 to to IN 10_1101-2021_01_04_425177 209 13 the the DT 10_1101-2021_01_04_425177 209 14 cellular cellular JJ 10_1101-2021_01_04_425177 209 15 prion prion NN 10_1101-2021_01_04_425177 209 16 protein protein NN 10_1101-2021_01_04_425177 209 17 . . . 10_1101-2021_01_04_425177 210 1 J J NNP 10_1101-2021_01_04_425177 210 2 Mol Mol NNP 10_1101-2021_01_04_425177 210 3 Biol Biol NNP 10_1101-2021_01_04_425177 210 4 314 314 CD 10_1101-2021_01_04_425177 210 5 , , , 10_1101-2021_01_04_425177 210 6 1209 1209 CD 10_1101-2021_01_04_425177 210 7 - - SYM 10_1101-2021_01_04_425177 210 8 1225 1225 CD 10_1101-2021_01_04_425177 210 9 . . . 10_1101-2021_01_04_425177 211 1 Sengupta Sengupta NNP 10_1101-2021_01_04_425177 211 2 , , , 10_1101-2021_01_04_425177 211 3 I. I. NNP 10_1101-2021_01_04_425177 211 4 , , , 10_1101-2021_01_04_425177 211 5 Udgaonkar Udgaonkar NNP 10_1101-2021_01_04_425177 211 6 , , , 10_1101-2021_01_04_425177 211 7 J.B. J.B. NNP 10_1101-2021_01_04_425177 211 8 , , , 10_1101-2021_01_04_425177 211 9 2018 2018 CD 10_1101-2021_01_04_425177 211 10 . . . 10_1101-2021_01_04_425177 212 1 Structural structural JJ 10_1101-2021_01_04_425177 212 2 mechanisms mechanism NNS 10_1101-2021_01_04_425177 212 3 of of IN 10_1101-2021_01_04_425177 212 4 oligomer oligomer NNP 10_1101-2021_01_04_425177 212 5 and and CC 10_1101-2021_01_04_425177 212 6 amyloid amyloid NNP 10_1101-2021_01_04_425177 212 7 fibril fibril NNP 10_1101-2021_01_04_425177 212 8 formation formation NN 10_1101-2021_01_04_425177 212 9 by by IN 10_1101-2021_01_04_425177 212 10 the the DT 10_1101-2021_01_04_425177 212 11 prion prion NN 10_1101-2021_01_04_425177 212 12 protein protein NN 10_1101-2021_01_04_425177 212 13 . . . 10_1101-2021_01_04_425177 213 1 Chem Chem NNP 10_1101-2021_01_04_425177 213 2 Commun Commun NNP 10_1101-2021_01_04_425177 213 3 ( ( -LRB- 10_1101-2021_01_04_425177 213 4 Camb camb NN 10_1101-2021_01_04_425177 213 5 ) ) -RRB- 10_1101-2021_01_04_425177 213 6 54 54 CD 10_1101-2021_01_04_425177 213 7 , , , 10_1101-2021_01_04_425177 213 8 6230 6230 CD 10_1101-2021_01_04_425177 213 9 - - SYM 10_1101-2021_01_04_425177 213 10 6242 6242 CD 10_1101-2021_01_04_425177 213 11 . . . 10_1101-2021_01_04_425177 214 1 Swietnicki Swietnicki NNP 10_1101-2021_01_04_425177 214 2 , , , 10_1101-2021_01_04_425177 214 3 W. W. NNP 10_1101-2021_01_04_425177 214 4 , , , 10_1101-2021_01_04_425177 214 5 Morillas Morillas NNP 10_1101-2021_01_04_425177 214 6 , , , 10_1101-2021_01_04_425177 214 7 M. M. NNP 10_1101-2021_01_04_425177 214 8 , , , 10_1101-2021_01_04_425177 214 9 Chen Chen NNP 10_1101-2021_01_04_425177 214 10 , , , 10_1101-2021_01_04_425177 214 11 S.G. S.G. NNP 10_1101-2021_01_04_425177 214 12 , , , 10_1101-2021_01_04_425177 214 13 Gambetti Gambetti NNP 10_1101-2021_01_04_425177 214 14 , , , 10_1101-2021_01_04_425177 214 15 P. P. NNP 10_1101-2021_01_04_425177 214 16 , , , 10_1101-2021_01_04_425177 214 17 Surewicz Surewicz NNP 10_1101-2021_01_04_425177 214 18 , , , 10_1101-2021_01_04_425177 214 19 W.K. W.K. NNP 10_1101-2021_01_04_425177 214 20 , , , 10_1101-2021_01_04_425177 214 21 2000 2000 CD 10_1101-2021_01_04_425177 214 22 . . . 10_1101-2021_01_04_425177 215 1 Aggregation aggregation NN 10_1101-2021_01_04_425177 215 2 and and CC 10_1101-2021_01_04_425177 215 3 fibrillization fibrillization NN 10_1101-2021_01_04_425177 215 4 of of IN 10_1101-2021_01_04_425177 215 5 the the DT 10_1101-2021_01_04_425177 215 6 recombinant recombinant JJ 10_1101-2021_01_04_425177 215 7 human human JJ 10_1101-2021_01_04_425177 215 8 prion prion NN 10_1101-2021_01_04_425177 215 9 protein protein NN 10_1101-2021_01_04_425177 215 10 huPrP90 huPrP90 NNP 10_1101-2021_01_04_425177 215 11 - - HYPH 10_1101-2021_01_04_425177 215 12 231 231 CD 10_1101-2021_01_04_425177 215 13 . . . 10_1101-2021_01_04_425177 216 1 Biochemistry Biochemistry NNP 10_1101-2021_01_04_425177 216 2 39 39 CD 10_1101-2021_01_04_425177 216 3 , , , 10_1101-2021_01_04_425177 216 4 424- 424- CD 10_1101-2021_01_04_425177 216 5 431 431 CD 10_1101-2021_01_04_425177 216 6 . . . 10_1101-2021_01_04_425177 217 1 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 217 2 , , , 10_1101-2021_01_04_425177 217 3 K.L. K.L. NNP 10_1101-2021_01_04_425177 217 4 , , , 10_1101-2021_01_04_425177 217 5 Guterstam Guterstam NNP 10_1101-2021_01_04_425177 217 6 , , , 10_1101-2021_01_04_425177 217 7 P. P. NNP 10_1101-2021_01_04_425177 217 8 , , , 10_1101-2021_01_04_425177 217 9 Langel Langel NNP 10_1101-2021_01_04_425177 217 10 , , , 10_1101-2021_01_04_425177 217 11 U. U. NNP 10_1101-2021_01_04_425177 217 12 , , , 10_1101-2021_01_04_425177 217 13 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 217 14 , , , 10_1101-2021_01_04_425177 217 15 A. a. NN 10_1101-2021_01_04_425177 217 16 , , , 10_1101-2021_01_04_425177 217 17 2014 2014 CD 10_1101-2021_01_04_425177 217 18 . . . 10_1101-2021_01_04_425177 218 1 Targeting target VBG 10_1101-2021_01_04_425177 218 2 prion prion NN 10_1101-2021_01_04_425177 218 3 propagation propagation NN 10_1101-2021_01_04_425177 218 4 using use VBG 10_1101-2021_01_04_425177 218 5 peptide peptide NN 10_1101-2021_01_04_425177 218 6 constructs construct NNS 10_1101-2021_01_04_425177 218 7 with with IN 10_1101-2021_01_04_425177 218 8 signal signal JJ 10_1101-2021_01_04_425177 218 9 sequence sequence NN 10_1101-2021_01_04_425177 218 10 motifs motif NNS 10_1101-2021_01_04_425177 218 11 . . . 10_1101-2021_01_04_425177 219 1 Arch Arch NNP 10_1101-2021_01_04_425177 219 2 Biochem Biochem NNP 10_1101-2021_01_04_425177 219 3 Biophys Biophys NNP 10_1101-2021_01_04_425177 219 4 564 564 CD 10_1101-2021_01_04_425177 219 5 , , , 10_1101-2021_01_04_425177 219 6 254 254 CD 10_1101-2021_01_04_425177 219 7 - - SYM 10_1101-2021_01_04_425177 219 8 261 261 CD 10_1101-2021_01_04_425177 219 9 . . . 10_1101-2021_01_04_425177 220 1 .CC .CC NFP 10_1101-2021_01_04_425177 220 2 - - : 10_1101-2021_01_04_425177 220 3 BY by IN 10_1101-2021_01_04_425177 220 4 - - HYPH 10_1101-2021_01_04_425177 220 5 NC NC NNP 10_1101-2021_01_04_425177 220 6 - - HYPH 10_1101-2021_01_04_425177 220 7 ND ND NNP 10_1101-2021_01_04_425177 220 8 4.0 4.0 CD 10_1101-2021_01_04_425177 220 9 International international JJ 10_1101-2021_01_04_425177 220 10 licensemade licensemade NN 10_1101-2021_01_04_425177 220 11 available available JJ 10_1101-2021_01_04_425177 220 12 under under IN 10_1101-2021_01_04_425177 220 13 a a DT 10_1101-2021_01_04_425177 220 14 ( ( -LRB- 10_1101-2021_01_04_425177 220 15 which which WDT 10_1101-2021_01_04_425177 220 16 was be VBD 10_1101-2021_01_04_425177 220 17 not not RB 10_1101-2021_01_04_425177 220 18 certified certify VBN 10_1101-2021_01_04_425177 220 19 by by IN 10_1101-2021_01_04_425177 220 20 peer peer NN 10_1101-2021_01_04_425177 220 21 review review NN 10_1101-2021_01_04_425177 220 22 ) ) -RRB- 10_1101-2021_01_04_425177 220 23 is be VBZ 10_1101-2021_01_04_425177 220 24 the the DT 10_1101-2021_01_04_425177 220 25 author author NN 10_1101-2021_01_04_425177 220 26 / / SYM 10_1101-2021_01_04_425177 220 27 funder funder NN 10_1101-2021_01_04_425177 220 28 , , , 10_1101-2021_01_04_425177 220 29 who who WP 10_1101-2021_01_04_425177 220 30 has have VBZ 10_1101-2021_01_04_425177 220 31 granted grant VBN 10_1101-2021_01_04_425177 220 32 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 220 33 a a DT 10_1101-2021_01_04_425177 220 34 license license NN 10_1101-2021_01_04_425177 220 35 to to TO 10_1101-2021_01_04_425177 220 36 display display VB 10_1101-2021_01_04_425177 220 37 the the DT 10_1101-2021_01_04_425177 220 38 preprint preprint NN 10_1101-2021_01_04_425177 220 39 in in IN 10_1101-2021_01_04_425177 220 40 perpetuity perpetuity NN 10_1101-2021_01_04_425177 220 41 . . . 10_1101-2021_01_04_425177 221 1 It -PRON- PRP 10_1101-2021_01_04_425177 221 2 is be VBZ 10_1101-2021_01_04_425177 221 3 The the DT 10_1101-2021_01_04_425177 221 4 copyright copyright NN 10_1101-2021_01_04_425177 221 5 holder holder NN 10_1101-2021_01_04_425177 221 6 for for IN 10_1101-2021_01_04_425177 221 7 this this DT 10_1101-2021_01_04_425177 221 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 221 9 version version NN 10_1101-2021_01_04_425177 221 10 posted post VBD 10_1101-2021_01_04_425177 221 11 January January NNP 10_1101-2021_01_04_425177 221 12 4 4 CD 10_1101-2021_01_04_425177 221 13 , , , 10_1101-2021_01_04_425177 221 14 2021 2021 CD 10_1101-2021_01_04_425177 221 15 . . . 10_1101-2021_01_04_425177 221 16 ; ; : 10_1101-2021_01_04_425177 221 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 221 18 : : : 10_1101-2021_01_04_425177 221 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 221 20 preprint preprint NN 10_1101-2021_01_04_425177 221 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 NNP 10_1101-2021_01_04_425177 221 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ CD 10_1101-2021_01_04_425177 221 23 12 12 CD 10_1101-2021_01_04_425177 221 24 Terry Terry NNP 10_1101-2021_01_04_425177 221 25 , , , 10_1101-2021_01_04_425177 221 26 C. C. NNP 10_1101-2021_01_04_425177 221 27 , , , 10_1101-2021_01_04_425177 221 28 Wadsworth Wadsworth NNP 10_1101-2021_01_04_425177 221 29 , , , 10_1101-2021_01_04_425177 221 30 J.D.F. J.D.F. NNP 10_1101-2021_01_04_425177 221 31 , , , 10_1101-2021_01_04_425177 221 32 2019 2019 CD 10_1101-2021_01_04_425177 221 33 . . . 10_1101-2021_01_04_425177 222 1 Recent recent JJ 10_1101-2021_01_04_425177 222 2 Advances advance NNS 10_1101-2021_01_04_425177 222 3 in in IN 10_1101-2021_01_04_425177 222 4 Understanding Understanding NNP 10_1101-2021_01_04_425177 222 5 Mammalian Mammalian NNP 10_1101-2021_01_04_425177 222 6 Prion Prion NNP 10_1101-2021_01_04_425177 222 7 Structure Structure NNP 10_1101-2021_01_04_425177 222 8 : : : 10_1101-2021_01_04_425177 222 9 A a DT 10_1101-2021_01_04_425177 222 10 Mini Mini NNP 10_1101-2021_01_04_425177 222 11 Review Review NNP 10_1101-2021_01_04_425177 222 12 . . . 10_1101-2021_01_04_425177 223 1 Front Front NNP 10_1101-2021_01_04_425177 223 2 Mol Mol NNP 10_1101-2021_01_04_425177 223 3 Neurosci Neurosci NNP 10_1101-2021_01_04_425177 223 4 12 12 CD 10_1101-2021_01_04_425177 223 5 , , , 10_1101-2021_01_04_425177 223 6 169 169 CD 10_1101-2021_01_04_425177 223 7 . . . 10_1101-2021_01_04_425177 224 1 Tjernberg Tjernberg NNP 10_1101-2021_01_04_425177 224 2 , , , 10_1101-2021_01_04_425177 224 3 L.O. L.O. NNP 10_1101-2021_01_04_425177 224 4 , , , 10_1101-2021_01_04_425177 224 5 Näslund Näslund NNP 10_1101-2021_01_04_425177 224 6 , , , 10_1101-2021_01_04_425177 224 7 J. J. NNP 10_1101-2021_01_04_425177 224 8 , , , 10_1101-2021_01_04_425177 224 9 Lindqvist Lindqvist NNP 10_1101-2021_01_04_425177 224 10 , , , 10_1101-2021_01_04_425177 224 11 F. F. NNP 10_1101-2021_01_04_425177 224 12 , , , 10_1101-2021_01_04_425177 224 13 Johansson Johansson NNP 10_1101-2021_01_04_425177 224 14 , , , 10_1101-2021_01_04_425177 224 15 J. J. NNP 10_1101-2021_01_04_425177 224 16 , , , 10_1101-2021_01_04_425177 224 17 Karlström Karlström NNP 10_1101-2021_01_04_425177 224 18 , , , 10_1101-2021_01_04_425177 224 19 A.R. A.R. NNP 10_1101-2021_01_04_425177 224 20 , , , 10_1101-2021_01_04_425177 224 21 Thyberg Thyberg NNP 10_1101-2021_01_04_425177 224 22 , , , 10_1101-2021_01_04_425177 224 23 J. J. NNP 10_1101-2021_01_04_425177 224 24 , , , 10_1101-2021_01_04_425177 224 25 Terenius Terenius NNP 10_1101-2021_01_04_425177 224 26 , , , 10_1101-2021_01_04_425177 224 27 L. L. NNP 10_1101-2021_01_04_425177 224 28 , , , 10_1101-2021_01_04_425177 224 29 Nordstedt Nordstedt NNP 10_1101-2021_01_04_425177 224 30 , , , 10_1101-2021_01_04_425177 224 31 C. C. NNP 10_1101-2021_01_04_425177 224 32 , , , 10_1101-2021_01_04_425177 224 33 1996 1996 CD 10_1101-2021_01_04_425177 224 34 . . . 10_1101-2021_01_04_425177 225 1 Arrest arrest NN 10_1101-2021_01_04_425177 225 2 of of IN 10_1101-2021_01_04_425177 225 3 beta beta JJ 10_1101-2021_01_04_425177 225 4 - - HYPH 10_1101-2021_01_04_425177 225 5 amyloid amyloid NN 10_1101-2021_01_04_425177 225 6 fibril fibril NN 10_1101-2021_01_04_425177 225 7 formation formation NN 10_1101-2021_01_04_425177 225 8 by by IN 10_1101-2021_01_04_425177 225 9 a a DT 10_1101-2021_01_04_425177 225 10 pentapeptide pentapeptide NN 10_1101-2021_01_04_425177 225 11 ligand ligand NN 10_1101-2021_01_04_425177 225 12 . . . 10_1101-2021_01_04_425177 226 1 J J NNP 10_1101-2021_01_04_425177 226 2 Biol Biol NNP 10_1101-2021_01_04_425177 226 3 Chem Chem NNP 10_1101-2021_01_04_425177 226 4 271 271 CD 10_1101-2021_01_04_425177 226 5 , , , 10_1101-2021_01_04_425177 226 6 8545 8545 CD 10_1101-2021_01_04_425177 226 7 - - SYM 10_1101-2021_01_04_425177 226 8 8548 8548 CD 10_1101-2021_01_04_425177 226 9 . . . 10_1101-2021_01_04_425177 227 1 Vazquez Vazquez NNP 10_1101-2021_01_04_425177 227 2 - - HYPH 10_1101-2021_01_04_425177 227 3 Fernandez Fernandez NNP 10_1101-2021_01_04_425177 227 4 , , , 10_1101-2021_01_04_425177 227 5 E. E. NNP 10_1101-2021_01_04_425177 227 6 , , , 10_1101-2021_01_04_425177 227 7 Young Young NNP 10_1101-2021_01_04_425177 227 8 , , , 10_1101-2021_01_04_425177 227 9 H.S. H.S. NNP 10_1101-2021_01_04_425177 227 10 , , , 10_1101-2021_01_04_425177 227 11 Requena Requena NNP 10_1101-2021_01_04_425177 227 12 , , , 10_1101-2021_01_04_425177 227 13 J.R. J.R. NNP 10_1101-2021_01_04_425177 227 14 , , , 10_1101-2021_01_04_425177 227 15 Wille Wille NNP 10_1101-2021_01_04_425177 227 16 , , , 10_1101-2021_01_04_425177 227 17 H. H. NNP 10_1101-2021_01_04_425177 227 18 , , , 10_1101-2021_01_04_425177 227 19 2017 2017 CD 10_1101-2021_01_04_425177 227 20 . . . 10_1101-2021_01_04_425177 228 1 The the DT 10_1101-2021_01_04_425177 228 2 Structure Structure NNP 10_1101-2021_01_04_425177 228 3 of of IN 10_1101-2021_01_04_425177 228 4 Mammalian Mammalian NNP 10_1101-2021_01_04_425177 228 5 Prions Prions NNPS 10_1101-2021_01_04_425177 228 6 and and CC 10_1101-2021_01_04_425177 228 7 Their -PRON- PRP$ 10_1101-2021_01_04_425177 228 8 Aggregates Aggregates NNPS 10_1101-2021_01_04_425177 228 9 . . . 10_1101-2021_01_04_425177 229 1 Int Int NNP 10_1101-2021_01_04_425177 229 2 Rev Rev NNP 10_1101-2021_01_04_425177 229 3 Cell Cell NNP 10_1101-2021_01_04_425177 229 4 Mol Mol NNP 10_1101-2021_01_04_425177 229 5 Biol Biol NNP 10_1101-2021_01_04_425177 229 6 329 329 CD 10_1101-2021_01_04_425177 229 7 , , , 10_1101-2021_01_04_425177 229 8 277 277 CD 10_1101-2021_01_04_425177 229 9 - - SYM 10_1101-2021_01_04_425177 229 10 301 301 CD 10_1101-2021_01_04_425177 229 11 . . . 10_1101-2021_01_04_425177 230 1 Verma Verma NNP 10_1101-2021_01_04_425177 230 2 , , , 10_1101-2021_01_04_425177 230 3 M. M. NNP 10_1101-2021_01_04_425177 230 4 , , , 10_1101-2021_01_04_425177 230 5 Vats Vats NNP 10_1101-2021_01_04_425177 230 6 , , , 10_1101-2021_01_04_425177 230 7 A. A. NNP 10_1101-2021_01_04_425177 230 8 , , , 10_1101-2021_01_04_425177 230 9 Taneja Taneja NNP 10_1101-2021_01_04_425177 230 10 , , , 10_1101-2021_01_04_425177 230 11 V. V. NNP 10_1101-2021_01_04_425177 230 12 , , , 10_1101-2021_01_04_425177 230 13 2015 2015 CD 10_1101-2021_01_04_425177 230 14 . . . 10_1101-2021_01_04_425177 231 1 Toxic toxic JJ 10_1101-2021_01_04_425177 231 2 species specie NNS 10_1101-2021_01_04_425177 231 3 in in IN 10_1101-2021_01_04_425177 231 4 amyloid amyloid NN 10_1101-2021_01_04_425177 231 5 disorders disorder NNS 10_1101-2021_01_04_425177 231 6 : : : 10_1101-2021_01_04_425177 231 7 Oligomers oligomer NNS 10_1101-2021_01_04_425177 231 8 or or CC 10_1101-2021_01_04_425177 231 9 mature mature JJ 10_1101-2021_01_04_425177 231 10 fibrils fibril NNS 10_1101-2021_01_04_425177 231 11 . . . 10_1101-2021_01_04_425177 232 1 Ann Ann NNP 10_1101-2021_01_04_425177 232 2 Indian Indian NNP 10_1101-2021_01_04_425177 232 3 Acad Acad NNP 10_1101-2021_01_04_425177 232 4 Neurol Neurol NNP 10_1101-2021_01_04_425177 232 5 18 18 CD 10_1101-2021_01_04_425177 232 6 , , , 10_1101-2021_01_04_425177 232 7 138 138 CD 10_1101-2021_01_04_425177 232 8 - - SYM 10_1101-2021_01_04_425177 232 9 145 145 CD 10_1101-2021_01_04_425177 232 10 . . . 10_1101-2021_01_04_425177 233 1 Wallin Wallin NNP 10_1101-2021_01_04_425177 233 2 , , , 10_1101-2021_01_04_425177 233 3 C. C. NNP 10_1101-2021_01_04_425177 233 4 , , , 10_1101-2021_01_04_425177 233 5 Hiruma Hiruma NNP 10_1101-2021_01_04_425177 233 6 , , , 10_1101-2021_01_04_425177 233 7 Y. Y. NNP 10_1101-2021_01_04_425177 233 8 , , , 10_1101-2021_01_04_425177 233 9 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 233 10 , , , 10_1101-2021_01_04_425177 233 11 S. S. NNP 10_1101-2021_01_04_425177 233 12 , , , 10_1101-2021_01_04_425177 233 13 Huvent Huvent NNP 10_1101-2021_01_04_425177 233 14 , , , 10_1101-2021_01_04_425177 233 15 I. I. NNP 10_1101-2021_01_04_425177 233 16 , , , 10_1101-2021_01_04_425177 233 17 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 233 18 , , , 10_1101-2021_01_04_425177 233 19 J. J. NNP 10_1101-2021_01_04_425177 233 20 , , , 10_1101-2021_01_04_425177 233 21 Abrahams Abrahams NNP 10_1101-2021_01_04_425177 233 22 , , , 10_1101-2021_01_04_425177 233 23 J.P. J.P. NNP 10_1101-2021_01_04_425177 233 24 , , , 10_1101-2021_01_04_425177 233 25 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 233 26 , , , 10_1101-2021_01_04_425177 233 27 A. a. NN 10_1101-2021_01_04_425177 233 28 , , , 10_1101-2021_01_04_425177 233 29 Lippens Lippens NNP 10_1101-2021_01_04_425177 233 30 , , , 10_1101-2021_01_04_425177 233 31 G. G. NNP 10_1101-2021_01_04_425177 233 32 , , , 10_1101-2021_01_04_425177 233 33 Luo Luo NNP 10_1101-2021_01_04_425177 233 34 , , , 10_1101-2021_01_04_425177 233 35 J. J. NNP 10_1101-2021_01_04_425177 233 36 , , , 10_1101-2021_01_04_425177 233 37 2018 2018 CD 10_1101-2021_01_04_425177 233 38 . . . 10_1101-2021_01_04_425177 234 1 The the DT 10_1101-2021_01_04_425177 234 2 Neuronal Neuronal NNP 10_1101-2021_01_04_425177 234 3 Tau Tau NNP 10_1101-2021_01_04_425177 234 4 Protein Protein NNP 10_1101-2021_01_04_425177 234 5 Blocks Blocks NNPS 10_1101-2021_01_04_425177 234 6 in in IN 10_1101-2021_01_04_425177 234 7 Vitro Vitro NNP 10_1101-2021_01_04_425177 234 8 Fibrillation Fibrillation NNP 10_1101-2021_01_04_425177 234 9 of of IN 10_1101-2021_01_04_425177 234 10 the the DT 10_1101-2021_01_04_425177 234 11 Amyloid Amyloid NNP 10_1101-2021_01_04_425177 234 12 - - HYPH 10_1101-2021_01_04_425177 234 13 beta beta NN 10_1101-2021_01_04_425177 234 14 ( ( -LRB- 10_1101-2021_01_04_425177 234 15 Abeta Abeta NNP 10_1101-2021_01_04_425177 234 16 ) ) -RRB- 10_1101-2021_01_04_425177 234 17 Peptide peptide VB 10_1101-2021_01_04_425177 234 18 at at IN 10_1101-2021_01_04_425177 234 19 the the DT 10_1101-2021_01_04_425177 234 20 Oligomeric Oligomeric NNP 10_1101-2021_01_04_425177 234 21 Stage Stage NNP 10_1101-2021_01_04_425177 234 22 . . . 10_1101-2021_01_04_425177 235 1 J J NNP 10_1101-2021_01_04_425177 235 2 Am Am NNP 10_1101-2021_01_04_425177 235 3 Chem Chem NNP 10_1101-2021_01_04_425177 235 4 Soc Soc NNP 10_1101-2021_01_04_425177 235 5 140 140 CD 10_1101-2021_01_04_425177 235 6 , , , 10_1101-2021_01_04_425177 235 7 8138 8138 CD 10_1101-2021_01_04_425177 235 8 - - SYM 10_1101-2021_01_04_425177 235 9 8146 8146 CD 10_1101-2021_01_04_425177 235 10 . . . 10_1101-2021_01_04_425177 236 1 Wallin Wallin NNP 10_1101-2021_01_04_425177 236 2 , , , 10_1101-2021_01_04_425177 236 3 C. C. NNP 10_1101-2021_01_04_425177 236 4 , , , 10_1101-2021_01_04_425177 236 5 Luo Luo NNP 10_1101-2021_01_04_425177 236 6 , , , 10_1101-2021_01_04_425177 236 7 J. J. NNP 10_1101-2021_01_04_425177 236 8 , , , 10_1101-2021_01_04_425177 236 9 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 236 10 , , , 10_1101-2021_01_04_425177 236 11 J. J. NNP 10_1101-2021_01_04_425177 236 12 , , , 10_1101-2021_01_04_425177 236 13 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 236 14 , , , 10_1101-2021_01_04_425177 236 15 S.K.T.S. S.K.T.S. NNP 10_1101-2021_01_04_425177 236 16 , , , 10_1101-2021_01_04_425177 236 17 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 236 18 , , , 10_1101-2021_01_04_425177 236 19 A. a. NN 10_1101-2021_01_04_425177 236 20 , , , 10_1101-2021_01_04_425177 236 21 2017 2017 CD 10_1101-2021_01_04_425177 236 22 . . . 10_1101-2021_01_04_425177 237 1 The the DT 10_1101-2021_01_04_425177 237 2 Amyloid Amyloid NNP 10_1101-2021_01_04_425177 237 3 - - HYPH 10_1101-2021_01_04_425177 237 4 b b NN 10_1101-2021_01_04_425177 237 5 Peptide peptide NN 10_1101-2021_01_04_425177 237 6 in in IN 10_1101-2021_01_04_425177 237 7 Amyloid Amyloid NNP 10_1101-2021_01_04_425177 237 8 Formation Formation NNP 10_1101-2021_01_04_425177 237 9 Processes Processes NNPS 10_1101-2021_01_04_425177 237 10 : : : 10_1101-2021_01_04_425177 237 11 Interactions interaction NNS 10_1101-2021_01_04_425177 237 12 with with IN 10_1101-2021_01_04_425177 237 13 Blood Blood NNP 10_1101-2021_01_04_425177 237 14 Proteins Proteins NNPS 10_1101-2021_01_04_425177 237 15 and and CC 10_1101-2021_01_04_425177 237 16 Naturally naturally RB 10_1101-2021_01_04_425177 237 17 Occurring Occurring NNP 10_1101-2021_01_04_425177 237 18 Metal Metal NNP 10_1101-2021_01_04_425177 237 19 Ions ion NNS 10_1101-2021_01_04_425177 237 20 . . . 10_1101-2021_01_04_425177 238 1 Israel Israel NNP 10_1101-2021_01_04_425177 238 2 Journal Journal NNP 10_1101-2021_01_04_425177 238 3 of of IN 10_1101-2021_01_04_425177 238 4 Chemistry Chemistry NNP 10_1101-2021_01_04_425177 238 5 57 57 CD 10_1101-2021_01_04_425177 238 6 , , , 10_1101-2021_01_04_425177 238 7 674 674 CD 10_1101-2021_01_04_425177 238 8 - - SYM 10_1101-2021_01_04_425177 238 9 685 685 CD 10_1101-2021_01_04_425177 238 10 . . . 10_1101-2021_01_04_425177 239 1 Wang Wang NNP 10_1101-2021_01_04_425177 239 2 , , , 10_1101-2021_01_04_425177 239 3 C. C. NNP 10_1101-2021_01_04_425177 239 4 , , , 10_1101-2021_01_04_425177 239 5 Iashchishyn Iashchishyn NNP 10_1101-2021_01_04_425177 239 6 , , , 10_1101-2021_01_04_425177 239 7 I.A. I.A. NNP 10_1101-2021_01_04_425177 239 8 , , , 10_1101-2021_01_04_425177 239 9 Kara Kara NNP 10_1101-2021_01_04_425177 239 10 , , , 10_1101-2021_01_04_425177 239 11 J. J. NNP 10_1101-2021_01_04_425177 239 12 , , , 10_1101-2021_01_04_425177 239 13 Fodera Fodera NNP 10_1101-2021_01_04_425177 239 14 , , , 10_1101-2021_01_04_425177 239 15 V. V. NNP 10_1101-2021_01_04_425177 239 16 , , , 10_1101-2021_01_04_425177 239 17 Vetri Vetri NNP 10_1101-2021_01_04_425177 239 18 , , , 10_1101-2021_01_04_425177 239 19 V. V. NNP 10_1101-2021_01_04_425177 239 20 , , , 10_1101-2021_01_04_425177 239 21 Sancataldo Sancataldo NNP 10_1101-2021_01_04_425177 239 22 , , , 10_1101-2021_01_04_425177 239 23 G. G. NNP 10_1101-2021_01_04_425177 239 24 , , , 10_1101-2021_01_04_425177 239 25 Marklund Marklund NNP 10_1101-2021_01_04_425177 239 26 , , , 10_1101-2021_01_04_425177 239 27 N. N. NNP 10_1101-2021_01_04_425177 239 28 , , , 10_1101-2021_01_04_425177 239 29 Morozova- Morozova- NNP 10_1101-2021_01_04_425177 239 30 Roche Roche NNP 10_1101-2021_01_04_425177 239 31 , , , 10_1101-2021_01_04_425177 239 32 L.A. L.A. NNP 10_1101-2021_01_04_425177 239 33 , , , 10_1101-2021_01_04_425177 239 34 2019 2019 CD 10_1101-2021_01_04_425177 239 35 . . . 10_1101-2021_01_04_425177 240 1 Proinflammatory proinflammatory NN 10_1101-2021_01_04_425177 240 2 and and CC 10_1101-2021_01_04_425177 240 3 amyloidogenic amyloidogenic JJ 10_1101-2021_01_04_425177 240 4 S100A9 s100a9 NN 10_1101-2021_01_04_425177 240 5 induced induce VBN 10_1101-2021_01_04_425177 240 6 by by IN 10_1101-2021_01_04_425177 240 7 traumatic traumatic JJ 10_1101-2021_01_04_425177 240 8 brain brain NN 10_1101-2021_01_04_425177 240 9 injury injury NN 10_1101-2021_01_04_425177 240 10 in in IN 10_1101-2021_01_04_425177 240 11 mouse mouse NN 10_1101-2021_01_04_425177 240 12 model model NN 10_1101-2021_01_04_425177 240 13 . . . 10_1101-2021_01_04_425177 241 1 Neurosci Neurosci NNP 10_1101-2021_01_04_425177 241 2 Lett Lett NNP 10_1101-2021_01_04_425177 241 3 699 699 CD 10_1101-2021_01_04_425177 241 4 , , , 10_1101-2021_01_04_425177 241 5 199 199 CD 10_1101-2021_01_04_425177 241 6 - - SYM 10_1101-2021_01_04_425177 241 7 205 205 CD 10_1101-2021_01_04_425177 241 8 . . . 10_1101-2021_01_04_425177 242 1 Wang Wang NNP 10_1101-2021_01_04_425177 242 2 , , , 10_1101-2021_01_04_425177 242 3 C. C. NNP 10_1101-2021_01_04_425177 242 4 , , , 10_1101-2021_01_04_425177 242 5 Klechikov Klechikov NNP 10_1101-2021_01_04_425177 242 6 , , , 10_1101-2021_01_04_425177 242 7 A.G. A.G. NNP 10_1101-2021_01_04_425177 242 8 , , , 10_1101-2021_01_04_425177 242 9 Gharibyan Gharibyan NNP 10_1101-2021_01_04_425177 242 10 , , , 10_1101-2021_01_04_425177 242 11 A.L. A.L. NNP 10_1101-2021_01_04_425177 242 12 , , , 10_1101-2021_01_04_425177 242 13 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 242 14 , , , 10_1101-2021_01_04_425177 242 15 S.K.T.S. S.K.T.S. NNP 10_1101-2021_01_04_425177 242 16 , , , 10_1101-2021_01_04_425177 242 17 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 242 18 , , , 10_1101-2021_01_04_425177 242 19 J. J. NNP 10_1101-2021_01_04_425177 242 20 , , , 10_1101-2021_01_04_425177 242 21 Zhao Zhao NNP 10_1101-2021_01_04_425177 242 22 , , , 10_1101-2021_01_04_425177 242 23 L. L. NNP 10_1101-2021_01_04_425177 242 24 , , , 10_1101-2021_01_04_425177 242 25 Jia Jia NNP 10_1101-2021_01_04_425177 242 26 , , , 10_1101-2021_01_04_425177 242 27 X. X. NNP 10_1101-2021_01_04_425177 242 28 , , , 10_1101-2021_01_04_425177 242 29 Narayana Narayana NNP 10_1101-2021_01_04_425177 242 30 , , , 10_1101-2021_01_04_425177 242 31 V.K. V.K. NNP 10_1101-2021_01_04_425177 242 32 , , , 10_1101-2021_01_04_425177 242 33 Shankar Shankar NNP 10_1101-2021_01_04_425177 242 34 , , , 10_1101-2021_01_04_425177 242 35 S.K. S.K. NNP 10_1101-2021_01_04_425177 242 36 , , , 10_1101-2021_01_04_425177 242 37 Olofsson Olofsson NNP 10_1101-2021_01_04_425177 242 38 , , , 10_1101-2021_01_04_425177 242 39 A. A. NNP 10_1101-2021_01_04_425177 242 40 , , , 10_1101-2021_01_04_425177 242 41 Brännström Brännström NNP 10_1101-2021_01_04_425177 242 42 , , , 10_1101-2021_01_04_425177 242 43 T. T. NNP 10_1101-2021_01_04_425177 242 44 , , , 10_1101-2021_01_04_425177 242 45 Mu Mu NNP 10_1101-2021_01_04_425177 242 46 , , , 10_1101-2021_01_04_425177 242 47 Y. Y. NNP 10_1101-2021_01_04_425177 242 48 , , , 10_1101-2021_01_04_425177 242 49 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 242 50 , , , 10_1101-2021_01_04_425177 242 51 A. A. NNP 10_1101-2021_01_04_425177 242 52 , , , 10_1101-2021_01_04_425177 242 53 Morozova Morozova NNP 10_1101-2021_01_04_425177 242 54 - - HYPH 10_1101-2021_01_04_425177 242 55 Roche Roche NNP 10_1101-2021_01_04_425177 242 56 , , , 10_1101-2021_01_04_425177 242 57 L.A. L.A. NNP 10_1101-2021_01_04_425177 242 58 , , , 10_1101-2021_01_04_425177 242 59 2014 2014 CD 10_1101-2021_01_04_425177 242 60 . . . 10_1101-2021_01_04_425177 243 1 The the DT 10_1101-2021_01_04_425177 243 2 role role NN 10_1101-2021_01_04_425177 243 3 of of IN 10_1101-2021_01_04_425177 243 4 pro pro JJ 10_1101-2021_01_04_425177 243 5 - - JJ 10_1101-2021_01_04_425177 243 6 inflammatory inflammatory JJ 10_1101-2021_01_04_425177 243 7 S100A9 s100a9 NN 10_1101-2021_01_04_425177 243 8 in in IN 10_1101-2021_01_04_425177 243 9 Alzheimer Alzheimer NNP 10_1101-2021_01_04_425177 243 10 's 's POS 10_1101-2021_01_04_425177 243 11 disease disease NN 10_1101-2021_01_04_425177 243 12 amyloid- amyloid- NN 10_1101-2021_01_04_425177 243 13 neuroinflammatory neuroinflammatory NN 10_1101-2021_01_04_425177 243 14 cascade cascade NN 10_1101-2021_01_04_425177 243 15 . . . 10_1101-2021_01_04_425177 244 1 Acta Acta NNP 10_1101-2021_01_04_425177 244 2 Neuropathol Neuropathol NNP 10_1101-2021_01_04_425177 244 3 127 127 CD 10_1101-2021_01_04_425177 244 4 , , , 10_1101-2021_01_04_425177 244 5 507 507 CD 10_1101-2021_01_04_425177 244 6 - - HYPH 10_1101-2021_01_04_425177 244 7 522 522 CD 10_1101-2021_01_04_425177 244 8 . . . 10_1101-2021_01_04_425177 245 1 Wang Wang NNP 10_1101-2021_01_04_425177 245 2 , , , 10_1101-2021_01_04_425177 245 3 G. G. NNP 10_1101-2021_01_04_425177 245 4 , , , 10_1101-2021_01_04_425177 245 5 Li Li NNP 10_1101-2021_01_04_425177 245 6 , , , 10_1101-2021_01_04_425177 245 7 X. X. NNP 10_1101-2021_01_04_425177 245 8 , , , 10_1101-2021_01_04_425177 245 9 Wang Wang NNP 10_1101-2021_01_04_425177 245 10 , , , 10_1101-2021_01_04_425177 245 11 Z. Z. NNP 10_1101-2021_01_04_425177 245 12 , , , 10_1101-2021_01_04_425177 245 13 2016 2016 CD 10_1101-2021_01_04_425177 245 14 . . . 10_1101-2021_01_04_425177 246 1 APD3 APD3 NNP 10_1101-2021_01_04_425177 246 2 : : : 10_1101-2021_01_04_425177 246 3 the the DT 10_1101-2021_01_04_425177 246 4 antimicrobial antimicrobial JJ 10_1101-2021_01_04_425177 246 5 peptide peptide NN 10_1101-2021_01_04_425177 246 6 database database NN 10_1101-2021_01_04_425177 246 7 as as IN 10_1101-2021_01_04_425177 246 8 a a DT 10_1101-2021_01_04_425177 246 9 tool tool NN 10_1101-2021_01_04_425177 246 10 for for IN 10_1101-2021_01_04_425177 246 11 research research NN 10_1101-2021_01_04_425177 246 12 and and CC 10_1101-2021_01_04_425177 246 13 education education NN 10_1101-2021_01_04_425177 246 14 . . . 10_1101-2021_01_04_425177 247 1 Nucleic Nucleic NNP 10_1101-2021_01_04_425177 247 2 Acids Acids NNPS 10_1101-2021_01_04_425177 247 3 Res Res NNP 10_1101-2021_01_04_425177 247 4 44 44 CD 10_1101-2021_01_04_425177 247 5 , , , 10_1101-2021_01_04_425177 247 6 D1087 d1087 NN 10_1101-2021_01_04_425177 247 7 - - HYPH 10_1101-2021_01_04_425177 247 8 1093 1093 CD 10_1101-2021_01_04_425177 247 9 . . . 10_1101-2021_01_04_425177 248 1 Wimley Wimley NNP 10_1101-2021_01_04_425177 248 2 , , , 10_1101-2021_01_04_425177 248 3 W.C. W.C. NNP 10_1101-2021_01_04_425177 248 4 , , , 10_1101-2021_01_04_425177 248 5 White White NNP 10_1101-2021_01_04_425177 248 6 , , , 10_1101-2021_01_04_425177 248 7 S.H. S.H. NNP 10_1101-2021_01_04_425177 248 8 , , , 10_1101-2021_01_04_425177 248 9 1996 1996 CD 10_1101-2021_01_04_425177 248 10 . . . 10_1101-2021_01_04_425177 249 1 Experimentally experimentally RB 10_1101-2021_01_04_425177 249 2 determined determine VBN 10_1101-2021_01_04_425177 249 3 hydrophobicity hydrophobicity NN 10_1101-2021_01_04_425177 249 4 scale scale NN 10_1101-2021_01_04_425177 249 5 for for IN 10_1101-2021_01_04_425177 249 6 proteins protein NNS 10_1101-2021_01_04_425177 249 7 at at IN 10_1101-2021_01_04_425177 249 8 membrane membrane NN 10_1101-2021_01_04_425177 249 9 interfaces interface NNS 10_1101-2021_01_04_425177 249 10 . . . 10_1101-2021_01_04_425177 250 1 Nat Nat NNP 10_1101-2021_01_04_425177 250 2 Struct Struct NNP 10_1101-2021_01_04_425177 250 3 Biol Biol NNP 10_1101-2021_01_04_425177 250 4 3 3 CD 10_1101-2021_01_04_425177 250 5 , , , 10_1101-2021_01_04_425177 250 6 842 842 CD 10_1101-2021_01_04_425177 250 7 - - HYPH 10_1101-2021_01_04_425177 250 8 848 848 CD 10_1101-2021_01_04_425177 250 9 . . . 10_1101-2021_01_04_425177 251 1 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 251 2 , , , 10_1101-2021_01_04_425177 251 3 S.K.T.S. S.K.T.S. NNP 10_1101-2021_01_04_425177 251 4 , , , 10_1101-2021_01_04_425177 251 5 Tiiman Tiiman NNP 10_1101-2021_01_04_425177 251 6 , , , 10_1101-2021_01_04_425177 251 7 A. A. NNP 10_1101-2021_01_04_425177 251 8 , , , 10_1101-2021_01_04_425177 251 9 Abelein Abelein NNP 10_1101-2021_01_04_425177 251 10 , , , 10_1101-2021_01_04_425177 251 11 A. a. NN 10_1101-2021_01_04_425177 251 12 , , , 10_1101-2021_01_04_425177 251 13 Luo Luo NNP 10_1101-2021_01_04_425177 251 14 , , , 10_1101-2021_01_04_425177 251 15 J. J. NNP 10_1101-2021_01_04_425177 251 16 , , , 10_1101-2021_01_04_425177 251 17 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 251 18 , , , 10_1101-2021_01_04_425177 251 19 J. J. NNP 10_1101-2021_01_04_425177 251 20 , , , 10_1101-2021_01_04_425177 251 21 Söderberg Söderberg NNP 10_1101-2021_01_04_425177 251 22 , , , 10_1101-2021_01_04_425177 251 23 K.L. K.L. NNP 10_1101-2021_01_04_425177 251 24 , , , 10_1101-2021_01_04_425177 251 25 Danielsson Danielsson NNP 10_1101-2021_01_04_425177 251 26 , , , 10_1101-2021_01_04_425177 251 27 J. J. NNP 10_1101-2021_01_04_425177 251 28 , , , 10_1101-2021_01_04_425177 251 29 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 251 30 , , , 10_1101-2021_01_04_425177 251 31 A. a. NN 10_1101-2021_01_04_425177 251 32 , , , 10_1101-2021_01_04_425177 251 33 2013 2013 CD 10_1101-2021_01_04_425177 251 34 . . . 10_1101-2021_01_04_425177 252 1 Biophysical biophysical JJ 10_1101-2021_01_04_425177 252 2 studies study NNS 10_1101-2021_01_04_425177 252 3 of of IN 10_1101-2021_01_04_425177 252 4 the the DT 10_1101-2021_01_04_425177 252 5 amyloid amyloid NN 10_1101-2021_01_04_425177 252 6 beta beta NN 10_1101-2021_01_04_425177 252 7 - - HYPH 10_1101-2021_01_04_425177 252 8 peptide peptide NN 10_1101-2021_01_04_425177 252 9 : : : 10_1101-2021_01_04_425177 252 10 interactions interaction NNS 10_1101-2021_01_04_425177 252 11 with with IN 10_1101-2021_01_04_425177 252 12 metal metal NN 10_1101-2021_01_04_425177 252 13 ions ion NNS 10_1101-2021_01_04_425177 252 14 and and CC 10_1101-2021_01_04_425177 252 15 small small JJ 10_1101-2021_01_04_425177 252 16 molecules molecule NNS 10_1101-2021_01_04_425177 252 17 . . . 10_1101-2021_01_04_425177 253 1 Chembiochem Chembiochem NNP 10_1101-2021_01_04_425177 253 2 14 14 CD 10_1101-2021_01_04_425177 253 3 , , , 10_1101-2021_01_04_425177 253 4 1692 1692 CD 10_1101-2021_01_04_425177 253 5 - - SYM 10_1101-2021_01_04_425177 253 6 1704 1704 CD 10_1101-2021_01_04_425177 253 7 . . . 10_1101-2021_01_04_425177 254 1 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 254 2 , , , 10_1101-2021_01_04_425177 254 3 S.K.T.S. S.K.T.S. NNP 10_1101-2021_01_04_425177 254 4 , , , 10_1101-2021_01_04_425177 254 5 Österlund Österlund NNP 10_1101-2021_01_04_425177 254 6 , , , 10_1101-2021_01_04_425177 254 7 N. N. NNP 10_1101-2021_01_04_425177 254 8 , , , 10_1101-2021_01_04_425177 254 9 Wallin Wallin NNP 10_1101-2021_01_04_425177 254 10 , , , 10_1101-2021_01_04_425177 254 11 C. C. NNP 10_1101-2021_01_04_425177 254 12 , , , 10_1101-2021_01_04_425177 254 13 Wu Wu NNP 10_1101-2021_01_04_425177 254 14 , , , 10_1101-2021_01_04_425177 254 15 J. J. NNP 10_1101-2021_01_04_425177 254 16 , , , 10_1101-2021_01_04_425177 254 17 Luo Luo NNP 10_1101-2021_01_04_425177 254 18 , , , 10_1101-2021_01_04_425177 254 19 J. J. NNP 10_1101-2021_01_04_425177 254 20 , , , 10_1101-2021_01_04_425177 254 21 Tiiman Tiiman NNP 10_1101-2021_01_04_425177 254 22 , , , 10_1101-2021_01_04_425177 254 23 A. A. NNP 10_1101-2021_01_04_425177 254 24 , , , 10_1101-2021_01_04_425177 254 25 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 254 26 , , , 10_1101-2021_01_04_425177 254 27 J. J. NNP 10_1101-2021_01_04_425177 254 28 , , , 10_1101-2021_01_04_425177 254 29 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 254 30 , , , 10_1101-2021_01_04_425177 254 31 A. a. NN 10_1101-2021_01_04_425177 254 32 , , , 10_1101-2021_01_04_425177 254 33 2019 2019 CD 10_1101-2021_01_04_425177 254 34 . . . 10_1101-2021_01_04_425177 255 1 Metal metal NN 10_1101-2021_01_04_425177 255 2 binding bind VBG 10_1101-2021_01_04_425177 255 3 to to IN 10_1101-2021_01_04_425177 255 4 the the DT 10_1101-2021_01_04_425177 255 5 amyloid amyloid NN 10_1101-2021_01_04_425177 255 6 - - HYPH 10_1101-2021_01_04_425177 255 7 beta beta NN 10_1101-2021_01_04_425177 255 8 peptides peptide NNS 10_1101-2021_01_04_425177 255 9 in in IN 10_1101-2021_01_04_425177 255 10 the the DT 10_1101-2021_01_04_425177 255 11 presence presence NN 10_1101-2021_01_04_425177 255 12 of of IN 10_1101-2021_01_04_425177 255 13 biomembranes biomembrane NNS 10_1101-2021_01_04_425177 255 14 : : : 10_1101-2021_01_04_425177 255 15 potential potential JJ 10_1101-2021_01_04_425177 255 16 mechanisms mechanism NNS 10_1101-2021_01_04_425177 255 17 of of IN 10_1101-2021_01_04_425177 255 18 cell cell NN 10_1101-2021_01_04_425177 255 19 toxicity toxicity NN 10_1101-2021_01_04_425177 255 20 . . . 10_1101-2021_01_04_425177 256 1 J J NNP 10_1101-2021_01_04_425177 256 2 Biol Biol NNP 10_1101-2021_01_04_425177 256 3 Inorg Inorg NNP 10_1101-2021_01_04_425177 256 4 Chem Chem NNP 10_1101-2021_01_04_425177 256 5 24 24 CD 10_1101-2021_01_04_425177 256 6 , , , 10_1101-2021_01_04_425177 256 7 1189 1189 CD 10_1101-2021_01_04_425177 256 8 - - SYM 10_1101-2021_01_04_425177 256 9 1196 1196 CD 10_1101-2021_01_04_425177 256 10 . . . 10_1101-2021_01_04_425177 257 1 Yamaguchi Yamaguchi NNP 10_1101-2021_01_04_425177 257 2 , , , 10_1101-2021_01_04_425177 257 3 K.I. K.I. NNP 10_1101-2021_01_04_425177 257 4 , , , 10_1101-2021_01_04_425177 257 5 Kuwata Kuwata NNP 10_1101-2021_01_04_425177 257 6 , , , 10_1101-2021_01_04_425177 257 7 K. K. NNP 10_1101-2021_01_04_425177 257 8 , , , 10_1101-2021_01_04_425177 257 9 2018 2018 CD 10_1101-2021_01_04_425177 257 10 . . . 10_1101-2021_01_04_425177 258 1 Formation formation NN 10_1101-2021_01_04_425177 258 2 and and CC 10_1101-2021_01_04_425177 258 3 properties property NNS 10_1101-2021_01_04_425177 258 4 of of IN 10_1101-2021_01_04_425177 258 5 amyloid amyloid NN 10_1101-2021_01_04_425177 258 6 fibrils fibril NNS 10_1101-2021_01_04_425177 258 7 of of IN 10_1101-2021_01_04_425177 258 8 prion prion NN 10_1101-2021_01_04_425177 258 9 protein protein NN 10_1101-2021_01_04_425177 258 10 . . . 10_1101-2021_01_04_425177 259 1 Biophys Biophys NNP 10_1101-2021_01_04_425177 259 2 Rev Rev NNP 10_1101-2021_01_04_425177 259 3 10 10 CD 10_1101-2021_01_04_425177 259 4 , , , 10_1101-2021_01_04_425177 259 5 517 517 CD 10_1101-2021_01_04_425177 259 6 - - SYM 10_1101-2021_01_04_425177 259 7 525 525 CD 10_1101-2021_01_04_425177 259 8 . . . 10_1101-2021_01_04_425177 260 1 Zahn Zahn NNP 10_1101-2021_01_04_425177 260 2 , , , 10_1101-2021_01_04_425177 260 3 R. R. NNP 10_1101-2021_01_04_425177 260 4 , , , 10_1101-2021_01_04_425177 260 5 von von NNP 10_1101-2021_01_04_425177 260 6 Schroetter Schroetter NNP 10_1101-2021_01_04_425177 260 7 , , , 10_1101-2021_01_04_425177 260 8 C. C. NNP 10_1101-2021_01_04_425177 260 9 , , , 10_1101-2021_01_04_425177 260 10 Wüthrich Wüthrich NNP 10_1101-2021_01_04_425177 260 11 , , , 10_1101-2021_01_04_425177 260 12 K. K. NNP 10_1101-2021_01_04_425177 260 13 , , , 10_1101-2021_01_04_425177 260 14 1997 1997 CD 10_1101-2021_01_04_425177 260 15 . . . 10_1101-2021_01_04_425177 261 1 Human human JJ 10_1101-2021_01_04_425177 261 2 prion prion NN 10_1101-2021_01_04_425177 261 3 proteins protein NNS 10_1101-2021_01_04_425177 261 4 expressed express VBN 10_1101-2021_01_04_425177 261 5 in in IN 10_1101-2021_01_04_425177 261 6 Escherichia Escherichia NNP 10_1101-2021_01_04_425177 261 7 coli coli NNS 10_1101-2021_01_04_425177 261 8 and and CC 10_1101-2021_01_04_425177 261 9 purified purify VBN 10_1101-2021_01_04_425177 261 10 by by IN 10_1101-2021_01_04_425177 261 11 high high JJ 10_1101-2021_01_04_425177 261 12 - - HYPH 10_1101-2021_01_04_425177 261 13 affinity affinity NN 10_1101-2021_01_04_425177 261 14 column column NN 10_1101-2021_01_04_425177 261 15 refolding refolding NN 10_1101-2021_01_04_425177 261 16 . . . 10_1101-2021_01_04_425177 262 1 FEBS FEBS NNP 10_1101-2021_01_04_425177 262 2 Lett Lett NNP 10_1101-2021_01_04_425177 262 3 417 417 CD 10_1101-2021_01_04_425177 262 4 , , , 10_1101-2021_01_04_425177 262 5 400 400 CD 10_1101-2021_01_04_425177 262 6 - - SYM 10_1101-2021_01_04_425177 262 7 404 404 CD 10_1101-2021_01_04_425177 262 8 . . . 10_1101-2021_01_04_425177 263 1 Österlund Österlund NNP 10_1101-2021_01_04_425177 263 2 , , , 10_1101-2021_01_04_425177 263 3 N. N. NNP 10_1101-2021_01_04_425177 263 4 , , , 10_1101-2021_01_04_425177 263 5 Kulkarni Kulkarni NNP 10_1101-2021_01_04_425177 263 6 , , , 10_1101-2021_01_04_425177 263 7 Y.S. Y.S. NNP 10_1101-2021_01_04_425177 263 8 , , , 10_1101-2021_01_04_425177 263 9 Misiaszek Misiaszek NNP 10_1101-2021_01_04_425177 263 10 , , , 10_1101-2021_01_04_425177 263 11 A.D. A.D. NNP 10_1101-2021_01_04_425177 263 12 , , , 10_1101-2021_01_04_425177 263 13 Wallin Wallin NNP 10_1101-2021_01_04_425177 263 14 , , , 10_1101-2021_01_04_425177 263 15 C. C. NNP 10_1101-2021_01_04_425177 263 16 , , , 10_1101-2021_01_04_425177 263 17 Kruger Kruger NNP 10_1101-2021_01_04_425177 263 18 , , , 10_1101-2021_01_04_425177 263 19 D.M. D.M. NNP 10_1101-2021_01_04_425177 263 20 , , , 10_1101-2021_01_04_425177 263 21 Liao Liao NNP 10_1101-2021_01_04_425177 263 22 , , , 10_1101-2021_01_04_425177 263 23 Q. Q. NNP 10_1101-2021_01_04_425177 263 24 , , , 10_1101-2021_01_04_425177 263 25 Mashayekhy Mashayekhy NNP 10_1101-2021_01_04_425177 263 26 Rad Rad NNP 10_1101-2021_01_04_425177 263 27 , , , 10_1101-2021_01_04_425177 263 28 F. F. NNP 10_1101-2021_01_04_425177 263 29 , , , 10_1101-2021_01_04_425177 263 30 Jarvet Jarvet NNP 10_1101-2021_01_04_425177 263 31 , , , 10_1101-2021_01_04_425177 263 32 J. J. NNP 10_1101-2021_01_04_425177 263 33 , , , 10_1101-2021_01_04_425177 263 34 Strodel Strodel NNP 10_1101-2021_01_04_425177 263 35 , , , 10_1101-2021_01_04_425177 263 36 B. B. NNP 10_1101-2021_01_04_425177 263 37 , , , 10_1101-2021_01_04_425177 263 38 Wärmländer Wärmländer NNP 10_1101-2021_01_04_425177 263 39 , , , 10_1101-2021_01_04_425177 263 40 S.K.T.S. S.K.T.S. NNP 10_1101-2021_01_04_425177 263 41 , , , 10_1101-2021_01_04_425177 263 42 Ilag Ilag NNP 10_1101-2021_01_04_425177 263 43 , , , 10_1101-2021_01_04_425177 263 44 L.L. L.L. NNP 10_1101-2021_01_04_425177 263 45 , , , 10_1101-2021_01_04_425177 263 46 Kamerlin Kamerlin NNP 10_1101-2021_01_04_425177 263 47 , , , 10_1101-2021_01_04_425177 263 48 S.C.L. S.C.L. NNP 10_1101-2021_01_04_425177 263 49 , , , 10_1101-2021_01_04_425177 263 50 Gräslund Gräslund NNP 10_1101-2021_01_04_425177 263 51 , , , 10_1101-2021_01_04_425177 263 52 A. a. NN 10_1101-2021_01_04_425177 263 53 , , , 10_1101-2021_01_04_425177 263 54 2018 2018 CD 10_1101-2021_01_04_425177 263 55 . . . 10_1101-2021_01_04_425177 264 1 Amyloid amyloid JJ 10_1101-2021_01_04_425177 264 2 - - HYPH 10_1101-2021_01_04_425177 264 3 beta beta NN 10_1101-2021_01_04_425177 264 4 Peptide Peptide NNP 10_1101-2021_01_04_425177 264 5 Interactions Interactions NNPS 10_1101-2021_01_04_425177 264 6 with with IN 10_1101-2021_01_04_425177 264 7 Amphiphilic amphiphilic JJ 10_1101-2021_01_04_425177 264 8 Surfactants surfactant NNS 10_1101-2021_01_04_425177 264 9 : : : 10_1101-2021_01_04_425177 264 10 Electrostatic electrostatic JJ 10_1101-2021_01_04_425177 264 11 and and CC 10_1101-2021_01_04_425177 264 12 Hydrophobic Hydrophobic NNP 10_1101-2021_01_04_425177 264 13 Effects Effects NNPS 10_1101-2021_01_04_425177 264 14 . . . 10_1101-2021_01_04_425177 265 1 ACS ACS NNP 10_1101-2021_01_04_425177 265 2 Chem Chem NNP 10_1101-2021_01_04_425177 265 3 Neurosci Neurosci NNP 10_1101-2021_01_04_425177 265 4 9 9 CD 10_1101-2021_01_04_425177 265 5 , , , 10_1101-2021_01_04_425177 265 6 1680 1680 CD 10_1101-2021_01_04_425177 265 7 - - SYM 10_1101-2021_01_04_425177 265 8 1692 1692 CD 10_1101-2021_01_04_425177 265 9 . . . 10_1101-2021_01_04_425177 266 1 .CC .CC NFP 10_1101-2021_01_04_425177 266 2 - - : 10_1101-2021_01_04_425177 266 3 BY by IN 10_1101-2021_01_04_425177 266 4 - - HYPH 10_1101-2021_01_04_425177 266 5 NC NC NNP 10_1101-2021_01_04_425177 266 6 - - HYPH 10_1101-2021_01_04_425177 266 7 ND ND NNP 10_1101-2021_01_04_425177 266 8 4.0 4.0 CD 10_1101-2021_01_04_425177 266 9 International international JJ 10_1101-2021_01_04_425177 266 10 licensemade licensemade NN 10_1101-2021_01_04_425177 266 11 available available JJ 10_1101-2021_01_04_425177 266 12 under under IN 10_1101-2021_01_04_425177 266 13 a a DT 10_1101-2021_01_04_425177 266 14 ( ( -LRB- 10_1101-2021_01_04_425177 266 15 which which WDT 10_1101-2021_01_04_425177 266 16 was be VBD 10_1101-2021_01_04_425177 266 17 not not RB 10_1101-2021_01_04_425177 266 18 certified certify VBN 10_1101-2021_01_04_425177 266 19 by by IN 10_1101-2021_01_04_425177 266 20 peer peer NN 10_1101-2021_01_04_425177 266 21 review review NN 10_1101-2021_01_04_425177 266 22 ) ) -RRB- 10_1101-2021_01_04_425177 266 23 is be VBZ 10_1101-2021_01_04_425177 266 24 the the DT 10_1101-2021_01_04_425177 266 25 author author NN 10_1101-2021_01_04_425177 266 26 / / SYM 10_1101-2021_01_04_425177 266 27 funder funder NN 10_1101-2021_01_04_425177 266 28 , , , 10_1101-2021_01_04_425177 266 29 who who WP 10_1101-2021_01_04_425177 266 30 has have VBZ 10_1101-2021_01_04_425177 266 31 granted grant VBN 10_1101-2021_01_04_425177 266 32 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 266 33 a a DT 10_1101-2021_01_04_425177 266 34 license license NN 10_1101-2021_01_04_425177 266 35 to to TO 10_1101-2021_01_04_425177 266 36 display display VB 10_1101-2021_01_04_425177 266 37 the the DT 10_1101-2021_01_04_425177 266 38 preprint preprint NN 10_1101-2021_01_04_425177 266 39 in in IN 10_1101-2021_01_04_425177 266 40 perpetuity perpetuity NN 10_1101-2021_01_04_425177 266 41 . . . 10_1101-2021_01_04_425177 267 1 It -PRON- PRP 10_1101-2021_01_04_425177 267 2 is be VBZ 10_1101-2021_01_04_425177 267 3 The the DT 10_1101-2021_01_04_425177 267 4 copyright copyright NN 10_1101-2021_01_04_425177 267 5 holder holder NN 10_1101-2021_01_04_425177 267 6 for for IN 10_1101-2021_01_04_425177 267 7 this this DT 10_1101-2021_01_04_425177 267 8 preprintthis preprintthis NN 10_1101-2021_01_04_425177 267 9 version version NN 10_1101-2021_01_04_425177 267 10 posted post VBD 10_1101-2021_01_04_425177 267 11 January January NNP 10_1101-2021_01_04_425177 267 12 4 4 CD 10_1101-2021_01_04_425177 267 13 , , , 10_1101-2021_01_04_425177 267 14 2021 2021 CD 10_1101-2021_01_04_425177 267 15 . . . 10_1101-2021_01_04_425177 267 16 ; ; : 10_1101-2021_01_04_425177 267 17 https://doi.org/10.1101/2021.01.04.425177doi https://doi.org/10.1101/2021.01.04.425177doi ADD 10_1101-2021_01_04_425177 267 18 : : : 10_1101-2021_01_04_425177 267 19 bioRxiv biorxiv IN 10_1101-2021_01_04_425177 267 20 preprint preprint NN 10_1101-2021_01_04_425177 267 21 https://doi.org/10.1101/2021.01.04.425177 https://doi.org/10.1101/2021.01.04.425177 UH 10_1101-2021_01_04_425177 267 22 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ XX