id	sid	tid	token	lemma	pos
10_1101-2020_06_17_156679	1	1	87208811	87208811	CD
10_1101-2020_06_17_156679	1	2	1	1	CD
10_1101-2020_06_17_156679	1	3	A	a	DT
10_1101-2020_06_17_156679	1	4	COVID	COVID	NNP
10_1101-2020_06_17_156679	1	5	Moonshot	moonshot	NN
10_1101-2020_06_17_156679	1	6	:	:	:
10_1101-2020_06_17_156679	1	7	assessment	assessment	NN
10_1101-2020_06_17_156679	1	8	of	of	IN
10_1101-2020_06_17_156679	1	9	ligand	ligand	NNP
10_1101-2020_06_17_156679	1	10	binding	bind	VBG
10_1101-2020_06_17_156679	1	11	to	to	IN
10_1101-2020_06_17_156679	1	12	the	the	DT
10_1101-2020_06_17_156679	1	13	SARS	SARS	NNP
10_1101-2020_06_17_156679	1	14	-	-	HYPH
10_1101-2020_06_17_156679	1	15	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	1	16	main	main	JJ
10_1101-2020_06_17_156679	1	17	protease	protease	NN
10_1101-2020_06_17_156679	1	18	by	by	IN
10_1101-2020_06_17_156679	1	19	saturation	saturation	NN
10_1101-2020_06_17_156679	1	20	1	1	CD
10_1101-2020_06_17_156679	1	21	transfer	transfer	NN
10_1101-2020_06_17_156679	1	22	difference	difference	NN
10_1101-2020_06_17_156679	1	23	NMR	NMR	NNP
10_1101-2020_06_17_156679	1	24	spectroscopy	spectroscopy	NNP
10_1101-2020_06_17_156679	1	25	2	2	CD
10_1101-2020_06_17_156679	1	26	3	3	CD
10_1101-2020_06_17_156679	1	27	Anastassia	Anastassia	NNP
10_1101-2020_06_17_156679	1	28	L.	L.	NNP
10_1101-2020_06_17_156679	1	29	Kantsadi1	Kantsadi1	NNP
10_1101-2020_06_17_156679	1	30	,	,	,
10_1101-2020_06_17_156679	1	31	Emma	Emma	NNP
10_1101-2020_06_17_156679	1	32	Cattermole1	Cattermole1	NNP
10_1101-2020_06_17_156679	1	33	,	,	,
10_1101-2020_06_17_156679	1	34	Minos	Minos	NNP
10_1101-2020_06_17_156679	1	35	-	-	HYPH
10_1101-2020_06_17_156679	1	36	Timotheos	Timotheos	NNP
10_1101-2020_06_17_156679	1	37	Matsoukas2	Matsoukas2	NNP
10_1101-2020_06_17_156679	1	38	,	,	,
10_1101-2020_06_17_156679	1	39	Georgios	Georgios	NNP
10_1101-2020_06_17_156679	1	40	A.	A.	NNP
10_1101-2020_06_17_156679	1	41	Spyroulias2	Spyroulias2	NNP
10_1101-2020_06_17_156679	1	42	4	4	CD
10_1101-2020_06_17_156679	1	43	and	and	CC
10_1101-2020_06_17_156679	1	44	Ioannis	Ioannis	NNP
10_1101-2020_06_17_156679	1	45	Vakonakis1	Vakonakis1	NNP
10_1101-2020_06_17_156679	1	46	*	*	NFP
10_1101-2020_06_17_156679	1	47	5	5	CD
10_1101-2020_06_17_156679	1	48	1Department	1department	CD
10_1101-2020_06_17_156679	1	49	of	of	IN
10_1101-2020_06_17_156679	1	50	Biochemistry	Biochemistry	NNP
10_1101-2020_06_17_156679	1	51	,	,	,
10_1101-2020_06_17_156679	1	52	University	University	NNP
10_1101-2020_06_17_156679	1	53	of	of	IN
10_1101-2020_06_17_156679	1	54	Oxford	Oxford	NNP
10_1101-2020_06_17_156679	1	55	,	,	,
10_1101-2020_06_17_156679	1	56	South	South	NNP
10_1101-2020_06_17_156679	1	57	Parks	Parks	NNPS
10_1101-2020_06_17_156679	1	58	Road	Road	NNP
10_1101-2020_06_17_156679	1	59	,	,	,
10_1101-2020_06_17_156679	1	60	Oxford	Oxford	NNP
10_1101-2020_06_17_156679	1	61	OX1	OX1	NNP
10_1101-2020_06_17_156679	1	62	3QU	3QU	NNP
10_1101-2020_06_17_156679	1	63	,	,	,
10_1101-2020_06_17_156679	1	64	United	United	NNP
10_1101-2020_06_17_156679	1	65	6	6	CD
10_1101-2020_06_17_156679	1	66	Kingdom	Kingdom	NNP
10_1101-2020_06_17_156679	1	67	7	7	CD
10_1101-2020_06_17_156679	1	68	2Department	2department	CD
10_1101-2020_06_17_156679	1	69	of	of	IN
10_1101-2020_06_17_156679	1	70	Pharmacy	Pharmacy	NNP
10_1101-2020_06_17_156679	1	71	,	,	,
10_1101-2020_06_17_156679	1	72	University	University	NNP
10_1101-2020_06_17_156679	1	73	of	of	IN
10_1101-2020_06_17_156679	1	74	Patras	Patras	NNP
10_1101-2020_06_17_156679	1	75	,	,	,
10_1101-2020_06_17_156679	1	76	Panepistimioupoli	Panepistimioupoli	NNP
10_1101-2020_06_17_156679	1	77	Campus	Campus	NNP
10_1101-2020_06_17_156679	1	78	,	,	,
10_1101-2020_06_17_156679	1	79	GR-26504	GR-26504	NNP
10_1101-2020_06_17_156679	1	80	,	,	,
10_1101-2020_06_17_156679	1	81	Greece	Greece	NNP
10_1101-2020_06_17_156679	1	82	8	8	CD
10_1101-2020_06_17_156679	1	83	*	*	NFP
10_1101-2020_06_17_156679	1	84	To	to	TO
10_1101-2020_06_17_156679	1	85	whom	whom	WP
10_1101-2020_06_17_156679	1	86	correspondence	correspondence	NN
10_1101-2020_06_17_156679	1	87	should	should	MD
10_1101-2020_06_17_156679	1	88	be	be	VB
10_1101-2020_06_17_156679	1	89	addressed	address	VBN
10_1101-2020_06_17_156679	1	90	,	,	,
10_1101-2020_06_17_156679	1	91	e	e	NN
10_1101-2020_06_17_156679	1	92	-	-	NN
10_1101-2020_06_17_156679	1	93	mail	mail	NN
10_1101-2020_06_17_156679	1	94	:	:	:
10_1101-2020_06_17_156679	1	95	ioannis.vakonakis@bioch.ox.ac.uk	ioannis.vakonakis@bioch.ox.ac.uk	UH
10_1101-2020_06_17_156679	1	96	,	,	,
10_1101-2020_06_17_156679	1	97	Tel	Tel	NNP
10_1101-2020_06_17_156679	1	98	.	.	.
10_1101-2020_06_17_156679	2	1	:	:	:
10_1101-2020_06_17_156679	2	2	9	9	CD
10_1101-2020_06_17_156679	2	3	+44	+44	CD
10_1101-2020_06_17_156679	2	4	1865	1865	CD
10_1101-2020_06_17_156679	2	5	275725	275725	CD
10_1101-2020_06_17_156679	2	6	,	,	,
10_1101-2020_06_17_156679	2	7	Fax	fax	NN
10_1101-2020_06_17_156679	2	8	:	:	:
10_1101-2020_06_17_156679	2	9	+44	+44	ADD
10_1101-2020_06_17_156679	2	10	1865	1865	CD
10_1101-2020_06_17_156679	2	11	613201	613201	CD
10_1101-2020_06_17_156679	2	12	10	10	CD
10_1101-2020_06_17_156679	2	13	11	11	CD
10_1101-2020_06_17_156679	2	14	Short	short	JJ
10_1101-2020_06_17_156679	2	15	title	title	NN
10_1101-2020_06_17_156679	2	16	:	:	:
10_1101-2020_06_17_156679	2	17	Assessment	Assessment	NNP
10_1101-2020_06_17_156679	2	18	of	of	IN
10_1101-2020_06_17_156679	2	19	ligand	ligand	NN
10_1101-2020_06_17_156679	2	20	binding	bind	VBG
10_1101-2020_06_17_156679	2	21	to	to	IN
10_1101-2020_06_17_156679	2	22	SARS	SARS	NNP
10_1101-2020_06_17_156679	2	23	-	-	HYPH
10_1101-2020_06_17_156679	2	24	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	2	25	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	2	26	by	by	IN
10_1101-2020_06_17_156679	2	27	STD	STD	NNP
10_1101-2020_06_17_156679	2	28	-	-	HYPH
10_1101-2020_06_17_156679	2	29	NMR	NMR	NNP
10_1101-2020_06_17_156679	2	30	12	12	CD
10_1101-2020_06_17_156679	2	31	Keywords	Keywords	NNPS
10_1101-2020_06_17_156679	2	32	:	:	:
10_1101-2020_06_17_156679	2	33	SARS	SARS	NNP
10_1101-2020_06_17_156679	2	34	-	-	HYPH
10_1101-2020_06_17_156679	2	35	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	2	36	,	,	,
10_1101-2020_06_17_156679	2	37	COVID-19	COVID-19	NNP
10_1101-2020_06_17_156679	2	38	,	,	,
10_1101-2020_06_17_156679	2	39	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	2	40	,	,	,
10_1101-2020_06_17_156679	2	41	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	2	42	,	,	,
10_1101-2020_06_17_156679	2	43	NMR	NMR	NNP
10_1101-2020_06_17_156679	2	44	,	,	,
10_1101-2020_06_17_156679	2	45	STD	STD	NNP
10_1101-2020_06_17_156679	2	46	,	,	,
10_1101-2020_06_17_156679	2	47	screening	screening	NN
10_1101-2020_06_17_156679	2	48	,	,	,
10_1101-2020_06_17_156679	2	49	fragments	fragment	NNS
10_1101-2020_06_17_156679	2	50	,	,	,
10_1101-2020_06_17_156679	2	51	molecular	molecular	JJ
10_1101-2020_06_17_156679	2	52	13	13	CD
10_1101-2020_06_17_156679	2	53	dynamics	dynamic	NNS
10_1101-2020_06_17_156679	2	54	,	,	,
10_1101-2020_06_17_156679	2	55	MD	MD	NNP
10_1101-2020_06_17_156679	2	56	,	,	,
10_1101-2020_06_17_156679	2	57	competition	competition	NN
10_1101-2020_06_17_156679	2	58	14	14	CD
10_1101-2020_06_17_156679	2	59	15	15	CD
10_1101-2020_06_17_156679	2	60	.CC	.CC	:
10_1101-2020_06_17_156679	2	61	-	-	:
10_1101-2020_06_17_156679	2	62	BY	by	IN
10_1101-2020_06_17_156679	2	63	4.0	4.0	CD
10_1101-2020_06_17_156679	2	64	International	International	NNP
10_1101-2020_06_17_156679	2	65	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	2	66	under	under	IN
10_1101-2020_06_17_156679	2	67	a	a	DT
10_1101-2020_06_17_156679	2	68	(	(	-LRB-
10_1101-2020_06_17_156679	2	69	which	which	WDT
10_1101-2020_06_17_156679	2	70	was	be	VBD
10_1101-2020_06_17_156679	2	71	not	not	RB
10_1101-2020_06_17_156679	2	72	certified	certify	VBN
10_1101-2020_06_17_156679	2	73	by	by	IN
10_1101-2020_06_17_156679	2	74	peer	peer	NN
10_1101-2020_06_17_156679	2	75	review	review	NN
10_1101-2020_06_17_156679	2	76	)	)	-RRB-
10_1101-2020_06_17_156679	2	77	is	be	VBZ
10_1101-2020_06_17_156679	2	78	the	the	DT
10_1101-2020_06_17_156679	2	79	author	author	NN
10_1101-2020_06_17_156679	2	80	/	/	SYM
10_1101-2020_06_17_156679	2	81	funder	funder	NN
10_1101-2020_06_17_156679	2	82	,	,	,
10_1101-2020_06_17_156679	2	83	who	who	WP
10_1101-2020_06_17_156679	2	84	has	have	VBZ
10_1101-2020_06_17_156679	2	85	granted	grant	VBN
10_1101-2020_06_17_156679	2	86	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	2	87	a	a	DT
10_1101-2020_06_17_156679	2	88	license	license	NN
10_1101-2020_06_17_156679	2	89	to	to	TO
10_1101-2020_06_17_156679	2	90	display	display	VB
10_1101-2020_06_17_156679	2	91	the	the	DT
10_1101-2020_06_17_156679	2	92	preprint	preprint	NN
10_1101-2020_06_17_156679	2	93	in	in	IN
10_1101-2020_06_17_156679	2	94	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	2	95	.	.	.
10_1101-2020_06_17_156679	3	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	3	2	is	be	VBZ
10_1101-2020_06_17_156679	3	3	made	make	VBN
10_1101-2020_06_17_156679	3	4	The	the	DT
10_1101-2020_06_17_156679	3	5	copyright	copyright	NN
10_1101-2020_06_17_156679	3	6	holder	holder	NN
10_1101-2020_06_17_156679	3	7	for	for	IN
10_1101-2020_06_17_156679	3	8	this	this	DT
10_1101-2020_06_17_156679	3	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	3	10	version	version	NN
10_1101-2020_06_17_156679	3	11	posted	post	VBD
10_1101-2020_06_17_156679	3	12	January	January	NNP
10_1101-2020_06_17_156679	3	13	6	6	CD
10_1101-2020_06_17_156679	3	14	,	,	,
10_1101-2020_06_17_156679	3	15	2021	2021	CD
10_1101-2020_06_17_156679	3	16	.	.	.
10_1101-2020_06_17_156679	3	17	;	;	:
10_1101-2020_06_17_156679	3	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	3	19	:	:	:
10_1101-2020_06_17_156679	3	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	3	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	3	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	3	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	3	24	2	2	CD
10_1101-2020_06_17_156679	3	25	Abstract	Abstract	NNP
10_1101-2020_06_17_156679	3	26	16	16	CD
10_1101-2020_06_17_156679	3	27	Severe	severe	JJ
10_1101-2020_06_17_156679	3	28	acute	acute	JJ
10_1101-2020_06_17_156679	3	29	respiratory	respiratory	JJ
10_1101-2020_06_17_156679	3	30	syndrome	syndrome	NN
10_1101-2020_06_17_156679	3	31	coronavirus	coronaviru	NNS
10_1101-2020_06_17_156679	3	32	2	2	CD
10_1101-2020_06_17_156679	3	33	(	(	-LRB-
10_1101-2020_06_17_156679	3	34	SARS	SARS	NNP
10_1101-2020_06_17_156679	3	35	-	-	HYPH
10_1101-2020_06_17_156679	3	36	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	3	37	)	)	-RRB-
10_1101-2020_06_17_156679	3	38	is	be	VBZ
10_1101-2020_06_17_156679	3	39	the	the	DT
10_1101-2020_06_17_156679	3	40	etiological	etiological	JJ
10_1101-2020_06_17_156679	3	41	cause	cause	NN
10_1101-2020_06_17_156679	3	42	of	of	IN
10_1101-2020_06_17_156679	3	43	the	the	DT
10_1101-2020_06_17_156679	3	44	17	17	CD
10_1101-2020_06_17_156679	3	45	coronavirus	coronavirus	NNP
10_1101-2020_06_17_156679	3	46	disease	disease	NNP
10_1101-2020_06_17_156679	3	47	2019	2019	CD
10_1101-2020_06_17_156679	3	48	,	,	,
10_1101-2020_06_17_156679	3	49	for	for	IN
10_1101-2020_06_17_156679	3	50	which	which	WDT
10_1101-2020_06_17_156679	3	51	no	no	DT
10_1101-2020_06_17_156679	3	52	effective	effective	JJ
10_1101-2020_06_17_156679	3	53	therapeutics	therapeutic	NNS
10_1101-2020_06_17_156679	3	54	are	be	VBP
10_1101-2020_06_17_156679	3	55	available	available	JJ
10_1101-2020_06_17_156679	3	56	.	.	.
10_1101-2020_06_17_156679	4	1	The	the	DT
10_1101-2020_06_17_156679	4	2	SARS	SARS	NNP
10_1101-2020_06_17_156679	4	3	-	-	HYPH
10_1101-2020_06_17_156679	4	4	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	4	5	main	main	JJ
10_1101-2020_06_17_156679	4	6	18	18	CD
10_1101-2020_06_17_156679	4	7	protease	protease	NN
10_1101-2020_06_17_156679	4	8	(	(	-LRB-
10_1101-2020_06_17_156679	4	9	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	4	10	)	)	-RRB-
10_1101-2020_06_17_156679	4	11	is	be	VBZ
10_1101-2020_06_17_156679	4	12	essential	essential	JJ
10_1101-2020_06_17_156679	4	13	for	for	IN
10_1101-2020_06_17_156679	4	14	viral	viral	JJ
10_1101-2020_06_17_156679	4	15	replication	replication	NN
10_1101-2020_06_17_156679	4	16	and	and	CC
10_1101-2020_06_17_156679	4	17	constitutes	constitute	VBZ
10_1101-2020_06_17_156679	4	18	a	a	DT
10_1101-2020_06_17_156679	4	19	promising	promising	JJ
10_1101-2020_06_17_156679	4	20	therapeutic	therapeutic	JJ
10_1101-2020_06_17_156679	4	21	target	target	NN
10_1101-2020_06_17_156679	4	22	.	.	.
10_1101-2020_06_17_156679	5	1	Many	many	JJ
10_1101-2020_06_17_156679	5	2	19	19	CD
10_1101-2020_06_17_156679	5	3	efforts	effort	NNS
10_1101-2020_06_17_156679	5	4	aimed	aim	VBN
10_1101-2020_06_17_156679	5	5	at	at	IN
10_1101-2020_06_17_156679	5	6	deriving	derive	VBG
10_1101-2020_06_17_156679	5	7	effective	effective	JJ
10_1101-2020_06_17_156679	5	8	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	5	9	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	5	10	are	be	VBP
10_1101-2020_06_17_156679	5	11	currently	currently	RB
10_1101-2020_06_17_156679	5	12	underway	underway	JJ
10_1101-2020_06_17_156679	5	13	,	,	,
10_1101-2020_06_17_156679	5	14	including	include	VBG
10_1101-2020_06_17_156679	5	15	an	an	DT
10_1101-2020_06_17_156679	5	16	international	international	JJ
10_1101-2020_06_17_156679	5	17	20	20	CD
10_1101-2020_06_17_156679	5	18	open	open	JJ
10_1101-2020_06_17_156679	5	19	-	-	HYPH
10_1101-2020_06_17_156679	5	20	science	science	NN
10_1101-2020_06_17_156679	5	21	discovery	discovery	NN
10_1101-2020_06_17_156679	5	22	project	project	NN
10_1101-2020_06_17_156679	5	23	,	,	,
10_1101-2020_06_17_156679	5	24	codenamed	codenamed	NNP
10_1101-2020_06_17_156679	5	25	COVID	COVID	NNP
10_1101-2020_06_17_156679	5	26	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	5	27	.	.	.
10_1101-2020_06_17_156679	6	1	As	as	IN
10_1101-2020_06_17_156679	6	2	part	part	NN
10_1101-2020_06_17_156679	6	3	of	of	IN
10_1101-2020_06_17_156679	6	4	COVID	COVID	NNP
10_1101-2020_06_17_156679	6	5	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	6	6	,	,	,
10_1101-2020_06_17_156679	6	7	we	-PRON-	PRP
10_1101-2020_06_17_156679	6	8	used	use	VBD
10_1101-2020_06_17_156679	6	9	21	21	CD
10_1101-2020_06_17_156679	6	10	saturation	saturation	NN
10_1101-2020_06_17_156679	6	11	transfer	transfer	NN
10_1101-2020_06_17_156679	6	12	difference	difference	NN
10_1101-2020_06_17_156679	6	13	nuclear	nuclear	JJ
10_1101-2020_06_17_156679	6	14	magnetic	magnetic	JJ
10_1101-2020_06_17_156679	6	15	resonance	resonance	NN
10_1101-2020_06_17_156679	6	16	(	(	-LRB-
10_1101-2020_06_17_156679	6	17	STD	STD	NNP
10_1101-2020_06_17_156679	6	18	-	-	HYPH
10_1101-2020_06_17_156679	6	19	NMR	NMR	NNP
10_1101-2020_06_17_156679	6	20	)	)	-RRB-
10_1101-2020_06_17_156679	6	21	spectroscopy	spectroscopy	VBP
10_1101-2020_06_17_156679	6	22	to	to	TO
10_1101-2020_06_17_156679	6	23	assess	assess	VB
10_1101-2020_06_17_156679	6	24	the	the	DT
10_1101-2020_06_17_156679	6	25	22	22	CD
10_1101-2020_06_17_156679	6	26	binding	binding	NN
10_1101-2020_06_17_156679	6	27	of	of	IN
10_1101-2020_06_17_156679	6	28	putative	putative	JJ
10_1101-2020_06_17_156679	6	29	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	6	30	ligands	ligand	VBZ
10_1101-2020_06_17_156679	6	31	to	to	IN
10_1101-2020_06_17_156679	6	32	the	the	DT
10_1101-2020_06_17_156679	6	33	viral	viral	JJ
10_1101-2020_06_17_156679	6	34	protease	protease	NN
10_1101-2020_06_17_156679	6	35	,	,	,
10_1101-2020_06_17_156679	6	36	including	include	VBG
10_1101-2020_06_17_156679	6	37	molecules	molecule	NNS
10_1101-2020_06_17_156679	6	38	identified	identify	VBN
10_1101-2020_06_17_156679	6	39	by	by	IN
10_1101-2020_06_17_156679	6	40	23	23	CD
10_1101-2020_06_17_156679	6	41	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	6	42	fragment	fragment	NN
10_1101-2020_06_17_156679	6	43	screening	screening	NN
10_1101-2020_06_17_156679	6	44	and	and	CC
10_1101-2020_06_17_156679	6	45	novel	novel	JJ
10_1101-2020_06_17_156679	6	46	compounds	compound	NNS
10_1101-2020_06_17_156679	6	47	designed	design	VBN
10_1101-2020_06_17_156679	6	48	as	as	IN
10_1101-2020_06_17_156679	6	49	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	6	50	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	6	51	.	.	.
10_1101-2020_06_17_156679	7	1	In	in	IN
10_1101-2020_06_17_156679	7	2	this	this	DT
10_1101-2020_06_17_156679	7	3	24	24	CD
10_1101-2020_06_17_156679	7	4	manner	manner	NN
10_1101-2020_06_17_156679	7	5	,	,	,
10_1101-2020_06_17_156679	7	6	we	-PRON-	PRP
10_1101-2020_06_17_156679	7	7	aimed	aim	VBD
10_1101-2020_06_17_156679	7	8	to	to	TO
10_1101-2020_06_17_156679	7	9	complement	complement	VB
10_1101-2020_06_17_156679	7	10	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	7	11	activity	activity	NN
10_1101-2020_06_17_156679	7	12	assays	assays	RB
10_1101-2020_06_17_156679	7	13	of	of	IN
10_1101-2020_06_17_156679	7	14	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	7	15	performed	perform	VBN
10_1101-2020_06_17_156679	7	16	by	by	IN
10_1101-2020_06_17_156679	7	17	other	other	JJ
10_1101-2020_06_17_156679	7	18	groups	group	NNS
10_1101-2020_06_17_156679	7	19	with	with	IN
10_1101-2020_06_17_156679	7	20	25	25	CD
10_1101-2020_06_17_156679	7	21	information	information	NN
10_1101-2020_06_17_156679	7	22	on	on	IN
10_1101-2020_06_17_156679	7	23	ligand	ligand	NN
10_1101-2020_06_17_156679	7	24	affinity	affinity	NN
10_1101-2020_06_17_156679	7	25	.	.	.
10_1101-2020_06_17_156679	8	1	We	-PRON-	PRP
10_1101-2020_06_17_156679	8	2	have	have	VBP
10_1101-2020_06_17_156679	8	3	made	make	VBN
10_1101-2020_06_17_156679	8	4	the	the	DT
10_1101-2020_06_17_156679	8	5	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	8	6	STD	STD	NNP
10_1101-2020_06_17_156679	8	7	-	-	HYPH
10_1101-2020_06_17_156679	8	8	NMR	NMR	NNP
10_1101-2020_06_17_156679	8	9	data	datum	NNS
10_1101-2020_06_17_156679	8	10	publicly	publicly	RB
10_1101-2020_06_17_156679	8	11	available	available	JJ
10_1101-2020_06_17_156679	8	12	.	.	.
10_1101-2020_06_17_156679	9	1	Here	here	RB
10_1101-2020_06_17_156679	9	2	,	,	,
10_1101-2020_06_17_156679	9	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	9	4	26	26	CD
10_1101-2020_06_17_156679	9	5	provide	provide	VBP
10_1101-2020_06_17_156679	9	6	detailed	detailed	JJ
10_1101-2020_06_17_156679	9	7	information	information	NN
10_1101-2020_06_17_156679	9	8	on	on	IN
10_1101-2020_06_17_156679	9	9	the	the	DT
10_1101-2020_06_17_156679	9	10	NMR	NMR	NNP
10_1101-2020_06_17_156679	9	11	protocols	protocol	NNS
10_1101-2020_06_17_156679	9	12	used	use	VBN
10_1101-2020_06_17_156679	9	13	and	and	CC
10_1101-2020_06_17_156679	9	14	challenges	challenge	NNS
10_1101-2020_06_17_156679	9	15	faced	face	VBD
10_1101-2020_06_17_156679	9	16	,	,	,
10_1101-2020_06_17_156679	9	17	thereby	thereby	RB
10_1101-2020_06_17_156679	9	18	placing	place	VBG
10_1101-2020_06_17_156679	9	19	these	these	DT
10_1101-2020_06_17_156679	9	20	27	27	CD
10_1101-2020_06_17_156679	9	21	data	datum	NNS
10_1101-2020_06_17_156679	9	22	into	into	IN
10_1101-2020_06_17_156679	9	23	context	context	NN
10_1101-2020_06_17_156679	9	24	.	.	.
10_1101-2020_06_17_156679	10	1	Our	-PRON-	PRP$
10_1101-2020_06_17_156679	10	2	goal	goal	NN
10_1101-2020_06_17_156679	10	3	is	be	VBZ
10_1101-2020_06_17_156679	10	4	to	to	TO
10_1101-2020_06_17_156679	10	5	assist	assist	VB
10_1101-2020_06_17_156679	10	6	the	the	DT
10_1101-2020_06_17_156679	10	7	interpretation	interpretation	NN
10_1101-2020_06_17_156679	10	8	of	of	IN
10_1101-2020_06_17_156679	10	9	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	10	10	STD	STD	NNP
10_1101-2020_06_17_156679	10	11	-	-	HYPH
10_1101-2020_06_17_156679	10	12	NMR	NMR	NNP
10_1101-2020_06_17_156679	10	13	data	datum	NNS
10_1101-2020_06_17_156679	10	14	,	,	,
10_1101-2020_06_17_156679	10	15	thereby	thereby	RB
10_1101-2020_06_17_156679	10	16	accelerating	accelerate	VBG
10_1101-2020_06_17_156679	10	17	28	28	CD
10_1101-2020_06_17_156679	10	18	ongoing	ongoing	JJ
10_1101-2020_06_17_156679	10	19	drug	drug	NN
10_1101-2020_06_17_156679	10	20	design	design	NN
10_1101-2020_06_17_156679	10	21	efforts	effort	NNS
10_1101-2020_06_17_156679	10	22	.	.	.
10_1101-2020_06_17_156679	11	1	29	29	CD
10_1101-2020_06_17_156679	11	2	30	30	CD
10_1101-2020_06_17_156679	11	3	31	31	CD
10_1101-2020_06_17_156679	11	4	.CC	.CC	:
10_1101-2020_06_17_156679	11	5	-	-	:
10_1101-2020_06_17_156679	11	6	BY	by	IN
10_1101-2020_06_17_156679	11	7	4.0	4.0	CD
10_1101-2020_06_17_156679	11	8	International	International	NNP
10_1101-2020_06_17_156679	11	9	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	11	10	under	under	IN
10_1101-2020_06_17_156679	11	11	a	a	DT
10_1101-2020_06_17_156679	11	12	(	(	-LRB-
10_1101-2020_06_17_156679	11	13	which	which	WDT
10_1101-2020_06_17_156679	11	14	was	be	VBD
10_1101-2020_06_17_156679	11	15	not	not	RB
10_1101-2020_06_17_156679	11	16	certified	certify	VBN
10_1101-2020_06_17_156679	11	17	by	by	IN
10_1101-2020_06_17_156679	11	18	peer	peer	NN
10_1101-2020_06_17_156679	11	19	review	review	NN
10_1101-2020_06_17_156679	11	20	)	)	-RRB-
10_1101-2020_06_17_156679	11	21	is	be	VBZ
10_1101-2020_06_17_156679	11	22	the	the	DT
10_1101-2020_06_17_156679	11	23	author	author	NN
10_1101-2020_06_17_156679	11	24	/	/	SYM
10_1101-2020_06_17_156679	11	25	funder	funder	NN
10_1101-2020_06_17_156679	11	26	,	,	,
10_1101-2020_06_17_156679	11	27	who	who	WP
10_1101-2020_06_17_156679	11	28	has	have	VBZ
10_1101-2020_06_17_156679	11	29	granted	grant	VBN
10_1101-2020_06_17_156679	11	30	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	11	31	a	a	DT
10_1101-2020_06_17_156679	11	32	license	license	NN
10_1101-2020_06_17_156679	11	33	to	to	TO
10_1101-2020_06_17_156679	11	34	display	display	VB
10_1101-2020_06_17_156679	11	35	the	the	DT
10_1101-2020_06_17_156679	11	36	preprint	preprint	NN
10_1101-2020_06_17_156679	11	37	in	in	IN
10_1101-2020_06_17_156679	11	38	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	11	39	.	.	.
10_1101-2020_06_17_156679	12	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	12	2	is	be	VBZ
10_1101-2020_06_17_156679	12	3	made	make	VBN
10_1101-2020_06_17_156679	12	4	The	the	DT
10_1101-2020_06_17_156679	12	5	copyright	copyright	NN
10_1101-2020_06_17_156679	12	6	holder	holder	NN
10_1101-2020_06_17_156679	12	7	for	for	IN
10_1101-2020_06_17_156679	12	8	this	this	DT
10_1101-2020_06_17_156679	12	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	12	10	version	version	NN
10_1101-2020_06_17_156679	12	11	posted	post	VBD
10_1101-2020_06_17_156679	12	12	January	January	NNP
10_1101-2020_06_17_156679	12	13	6	6	CD
10_1101-2020_06_17_156679	12	14	,	,	,
10_1101-2020_06_17_156679	12	15	2021	2021	CD
10_1101-2020_06_17_156679	12	16	.	.	.
10_1101-2020_06_17_156679	12	17	;	;	:
10_1101-2020_06_17_156679	12	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	12	19	:	:	:
10_1101-2020_06_17_156679	12	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	12	21	preprint	preprint	NN
10_1101-2020_06_17_156679	12	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	12	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	12	24	3	3	CD
10_1101-2020_06_17_156679	12	25	Introduction	introduction	NN
10_1101-2020_06_17_156679	12	26	32	32	CD
10_1101-2020_06_17_156679	12	27	Infections	Infections	NNPS
10_1101-2020_06_17_156679	12	28	by	by	IN
10_1101-2020_06_17_156679	12	29	the	the	DT
10_1101-2020_06_17_156679	12	30	severe	severe	JJ
10_1101-2020_06_17_156679	12	31	acute	acute	JJ
10_1101-2020_06_17_156679	12	32	respiratory	respiratory	JJ
10_1101-2020_06_17_156679	12	33	syndrome	syndrome	NN
10_1101-2020_06_17_156679	12	34	coronavirus	coronaviru	NNS
10_1101-2020_06_17_156679	12	35	2	2	CD
10_1101-2020_06_17_156679	12	36	(	(	-LRB-
10_1101-2020_06_17_156679	12	37	SARS	SARS	NNP
10_1101-2020_06_17_156679	12	38	-	-	HYPH
10_1101-2020_06_17_156679	12	39	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	12	40	)	)	-RRB-
10_1101-2020_06_17_156679	12	41	resulted	result	VBD
10_1101-2020_06_17_156679	12	42	in	in	IN
10_1101-2020_06_17_156679	12	43	33	33	CD
10_1101-2020_06_17_156679	12	44	approximately	approximately	RB
10_1101-2020_06_17_156679	12	45	1.8	1.8	CD
10_1101-2020_06_17_156679	12	46	million	million	CD
10_1101-2020_06_17_156679	12	47	deaths	death	NNS
10_1101-2020_06_17_156679	12	48	in	in	IN
10_1101-2020_06_17_156679	12	49	2020	2020	CD
10_1101-2020_06_17_156679	12	50	(	(	-LRB-
10_1101-2020_06_17_156679	12	51	1	1	CD
10_1101-2020_06_17_156679	12	52	)	)	-RRB-
10_1101-2020_06_17_156679	12	53	and	and	CC
10_1101-2020_06_17_156679	12	54	led	lead	VBD
10_1101-2020_06_17_156679	12	55	to	to	IN
10_1101-2020_06_17_156679	12	56	the	the	DT
10_1101-2020_06_17_156679	12	57	coronavirus	coronavirus	NNP
10_1101-2020_06_17_156679	12	58	2019	2019	CD
10_1101-2020_06_17_156679	12	59	(	(	-LRB-
10_1101-2020_06_17_156679	12	60	COVID-19	COVID-19	NNP
10_1101-2020_06_17_156679	12	61	)	)	-RRB-
10_1101-2020_06_17_156679	12	62	pandemic	pandemic	NN
10_1101-2020_06_17_156679	12	63	34	34	CD
10_1101-2020_06_17_156679	12	64	(	(	-LRB-
10_1101-2020_06_17_156679	12	65	2	2	CD
10_1101-2020_06_17_156679	12	66	-	-	SYM
10_1101-2020_06_17_156679	12	67	4	4	CD
10_1101-2020_06_17_156679	12	68	)	)	-RRB-
10_1101-2020_06_17_156679	12	69	.	.	.
10_1101-2020_06_17_156679	13	1	SARS	SARS	NNP
10_1101-2020_06_17_156679	13	2	-	-	HYPH
10_1101-2020_06_17_156679	13	3	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	13	4	is	be	VBZ
10_1101-2020_06_17_156679	13	5	a	a	DT
10_1101-2020_06_17_156679	13	6	zoonotic	zoonotic	JJ
10_1101-2020_06_17_156679	13	7	betacoronavirus	betacoronavirus	NN
10_1101-2020_06_17_156679	13	8	highly	highly	RB
10_1101-2020_06_17_156679	13	9	similar	similar	JJ
10_1101-2020_06_17_156679	13	10	to	to	IN
10_1101-2020_06_17_156679	13	11	SARS	SARS	NNP
10_1101-2020_06_17_156679	13	12	-	-	HYPH
10_1101-2020_06_17_156679	13	13	CoV	CoV	NNP
10_1101-2020_06_17_156679	13	14	and	and	CC
10_1101-2020_06_17_156679	13	15	MERS	MERS	NNP
10_1101-2020_06_17_156679	13	16	-	-	HYPH
10_1101-2020_06_17_156679	13	17	CoV	CoV	NNP
10_1101-2020_06_17_156679	13	18	,	,	,
10_1101-2020_06_17_156679	13	19	which	which	WDT
10_1101-2020_06_17_156679	13	20	35	35	CD
10_1101-2020_06_17_156679	13	21	caused	cause	VBD
10_1101-2020_06_17_156679	13	22	outbreaks	outbreak	NNS
10_1101-2020_06_17_156679	13	23	in	in	IN
10_1101-2020_06_17_156679	13	24	2002	2002	CD
10_1101-2020_06_17_156679	13	25	and	and	CC
10_1101-2020_06_17_156679	13	26	2012	2012	CD
10_1101-2020_06_17_156679	13	27	,	,	,
10_1101-2020_06_17_156679	13	28	respectively	respectively	RB
10_1101-2020_06_17_156679	13	29	(	(	-LRB-
10_1101-2020_06_17_156679	13	30	5	5	CD
10_1101-2020_06_17_156679	13	31	-	-	SYM
10_1101-2020_06_17_156679	13	32	7	7	CD
10_1101-2020_06_17_156679	13	33	)	)	-RRB-
10_1101-2020_06_17_156679	13	34	.	.	.
10_1101-2020_06_17_156679	14	1	SARS	SARS	NNP
10_1101-2020_06_17_156679	14	2	-	-	HYPH
10_1101-2020_06_17_156679	14	3	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	14	4	encodes	encode	VBZ
10_1101-2020_06_17_156679	14	5	its	-PRON-	PRP$
10_1101-2020_06_17_156679	14	6	proteome	proteome	NN
10_1101-2020_06_17_156679	14	7	in	in	IN
10_1101-2020_06_17_156679	14	8	a	a	DT
10_1101-2020_06_17_156679	14	9	single	single	JJ
10_1101-2020_06_17_156679	14	10	,	,	,
10_1101-2020_06_17_156679	14	11	36	36	CD
10_1101-2020_06_17_156679	14	12	positive	positive	JJ
10_1101-2020_06_17_156679	14	13	-	-	HYPH
10_1101-2020_06_17_156679	14	14	sense	sense	NN
10_1101-2020_06_17_156679	14	15	,	,	,
10_1101-2020_06_17_156679	14	16	linear	linear	JJ
10_1101-2020_06_17_156679	14	17	RNA	RNA	NNP
10_1101-2020_06_17_156679	14	18	molecule	molecule	NN
10_1101-2020_06_17_156679	14	19	of	of	IN
10_1101-2020_06_17_156679	14	20	~30	~30	.
10_1101-2020_06_17_156679	14	21	kb	kb	NNP
10_1101-2020_06_17_156679	14	22	length	length	NNP
10_1101-2020_06_17_156679	14	23	,	,	,
10_1101-2020_06_17_156679	14	24	the	the	DT
10_1101-2020_06_17_156679	14	25	majority	majority	NN
10_1101-2020_06_17_156679	14	26	of	of	IN
10_1101-2020_06_17_156679	14	27	which	which	WDT
10_1101-2020_06_17_156679	14	28	(	(	-LRB-
10_1101-2020_06_17_156679	14	29	~21.5	~21.5	NFP
10_1101-2020_06_17_156679	14	30	kb	kb	NNP
10_1101-2020_06_17_156679	14	31	)	)	-RRB-
10_1101-2020_06_17_156679	14	32	is	be	VBZ
10_1101-2020_06_17_156679	14	33	translated	translate	VBN
10_1101-2020_06_17_156679	14	34	37	37	CD
10_1101-2020_06_17_156679	14	35	into	into	IN
10_1101-2020_06_17_156679	14	36	two	two	CD
10_1101-2020_06_17_156679	14	37	polypeptides	polypeptide	NNS
10_1101-2020_06_17_156679	14	38	,	,	,
10_1101-2020_06_17_156679	14	39	pp1a	pp1a	NNP
10_1101-2020_06_17_156679	14	40	and	and	CC
10_1101-2020_06_17_156679	14	41	pp1ab	pp1ab	NNP
10_1101-2020_06_17_156679	14	42	,	,	,
10_1101-2020_06_17_156679	14	43	via	via	IN
10_1101-2020_06_17_156679	14	44	ribosomal	ribosomal	JJ
10_1101-2020_06_17_156679	14	45	frame	frame	NN
10_1101-2020_06_17_156679	14	46	-	-	HYPH
10_1101-2020_06_17_156679	14	47	shifting	shifting	NN
10_1101-2020_06_17_156679	14	48	(	(	-LRB-
10_1101-2020_06_17_156679	14	49	8	8	CD
10_1101-2020_06_17_156679	14	50	,	,	,
10_1101-2020_06_17_156679	14	51	9	9	CD
10_1101-2020_06_17_156679	14	52	)	)	-RRB-
10_1101-2020_06_17_156679	14	53	.	.	.
10_1101-2020_06_17_156679	15	1	Key	key	JJ
10_1101-2020_06_17_156679	15	2	viral	viral	JJ
10_1101-2020_06_17_156679	15	3	enzymes	enzyme	NNS
10_1101-2020_06_17_156679	15	4	and	and	CC
10_1101-2020_06_17_156679	15	5	38	38	CD
10_1101-2020_06_17_156679	15	6	factors	factor	NNS
10_1101-2020_06_17_156679	15	7	,	,	,
10_1101-2020_06_17_156679	15	8	including	include	VBG
10_1101-2020_06_17_156679	15	9	most	most	JJS
10_1101-2020_06_17_156679	15	10	proteins	protein	NNS
10_1101-2020_06_17_156679	15	11	of	of	IN
10_1101-2020_06_17_156679	15	12	the	the	DT
10_1101-2020_06_17_156679	15	13	reverse	reverse	JJ
10_1101-2020_06_17_156679	15	14	-	-	HYPH
10_1101-2020_06_17_156679	15	15	transcriptase	transcriptase	NN
10_1101-2020_06_17_156679	15	16	machinery	machinery	NN
10_1101-2020_06_17_156679	15	17	,	,	,
10_1101-2020_06_17_156679	15	18	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	15	19	of	of	IN
10_1101-2020_06_17_156679	15	20	host	host	NN
10_1101-2020_06_17_156679	15	21	translation	translation	NN
10_1101-2020_06_17_156679	15	22	39	39	CD
10_1101-2020_06_17_156679	15	23	and	and	CC
10_1101-2020_06_17_156679	15	24	molecules	molecule	NNS
10_1101-2020_06_17_156679	15	25	signalling	signal	VBG
10_1101-2020_06_17_156679	15	26	for	for	IN
10_1101-2020_06_17_156679	15	27	host	host	NN
10_1101-2020_06_17_156679	15	28	cell	cell	NN
10_1101-2020_06_17_156679	15	29	survival	survival	NN
10_1101-2020_06_17_156679	15	30	,	,	,
10_1101-2020_06_17_156679	15	31	are	be	VBP
10_1101-2020_06_17_156679	15	32	released	release	VBN
10_1101-2020_06_17_156679	15	33	from	from	IN
10_1101-2020_06_17_156679	15	34	pp1a	pp1a	NNP
10_1101-2020_06_17_156679	15	35	and	and	CC
10_1101-2020_06_17_156679	15	36	pp1ab	pp1ab	NNP
10_1101-2020_06_17_156679	15	37	via	via	IN
10_1101-2020_06_17_156679	15	38	post-40	post-40	NN
10_1101-2020_06_17_156679	15	39	translational	translational	JJ
10_1101-2020_06_17_156679	15	40	cleavage	cleavage	NN
10_1101-2020_06_17_156679	15	41	by	by	IN
10_1101-2020_06_17_156679	15	42	two	two	CD
10_1101-2020_06_17_156679	15	43	viral	viral	JJ
10_1101-2020_06_17_156679	15	44	cysteine	cysteine	NN
10_1101-2020_06_17_156679	15	45	proteases	protease	NNS
10_1101-2020_06_17_156679	15	46	(	(	-LRB-
10_1101-2020_06_17_156679	15	47	10	10	CD
10_1101-2020_06_17_156679	15	48	)	)	-RRB-
10_1101-2020_06_17_156679	15	49	.	.	.
10_1101-2020_06_17_156679	16	1	These	these	DT
10_1101-2020_06_17_156679	16	2	proteases	protease	NNS
10_1101-2020_06_17_156679	16	3	,	,	,
10_1101-2020_06_17_156679	16	4	a	a	DT
10_1101-2020_06_17_156679	16	5	papain	papain	NN
10_1101-2020_06_17_156679	16	6	-	-	HYPH
10_1101-2020_06_17_156679	16	7	like	like	JJ
10_1101-2020_06_17_156679	16	8	enzyme	enzyme	NNS
10_1101-2020_06_17_156679	16	9	41	41	CD
10_1101-2020_06_17_156679	16	10	cleaving	cleave	VBG
10_1101-2020_06_17_156679	16	11	pp1ab	pp1ab	NNP
10_1101-2020_06_17_156679	16	12	at	at	IN
10_1101-2020_06_17_156679	16	13	three	three	CD
10_1101-2020_06_17_156679	16	14	sites	site	NNS
10_1101-2020_06_17_156679	16	15	,	,	,
10_1101-2020_06_17_156679	16	16	and	and	CC
10_1101-2020_06_17_156679	16	17	a	a	DT
10_1101-2020_06_17_156679	16	18	3C	3c	NN
10_1101-2020_06_17_156679	16	19	-	-	HYPH
10_1101-2020_06_17_156679	16	20	like	like	JJ
10_1101-2020_06_17_156679	16	21	protease	protease	NN
10_1101-2020_06_17_156679	16	22	cleaving	cleave	VBG
10_1101-2020_06_17_156679	16	23	the	the	DT
10_1101-2020_06_17_156679	16	24	polypeptide	polypeptide	NN
10_1101-2020_06_17_156679	16	25	at	at	IN
10_1101-2020_06_17_156679	16	26	11	11	CD
10_1101-2020_06_17_156679	16	27	sites	site	NNS
10_1101-2020_06_17_156679	16	28	,	,	,
10_1101-2020_06_17_156679	16	29	are	be	VBP
10_1101-2020_06_17_156679	16	30	primary	primary	JJ
10_1101-2020_06_17_156679	16	31	42	42	CD
10_1101-2020_06_17_156679	16	32	targets	target	NNS
10_1101-2020_06_17_156679	16	33	for	for	IN
10_1101-2020_06_17_156679	16	34	the	the	DT
10_1101-2020_06_17_156679	16	35	development	development	NN
10_1101-2020_06_17_156679	16	36	of	of	IN
10_1101-2020_06_17_156679	16	37	antiviral	antiviral	JJ
10_1101-2020_06_17_156679	16	38	drugs	drug	NNS
10_1101-2020_06_17_156679	16	39	.	.	.
10_1101-2020_06_17_156679	17	1	43	43	CD
10_1101-2020_06_17_156679	17	2	The	the	DT
10_1101-2020_06_17_156679	17	3	3C	3c	NN
10_1101-2020_06_17_156679	17	4	-	-	HYPH
10_1101-2020_06_17_156679	17	5	like	like	JJ
10_1101-2020_06_17_156679	17	6	protease	protease	NN
10_1101-2020_06_17_156679	17	7	of	of	IN
10_1101-2020_06_17_156679	17	8	SARS	SARS	NNP
10_1101-2020_06_17_156679	17	9	-	-	HYPH
10_1101-2020_06_17_156679	17	10	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	17	11	,	,	,
10_1101-2020_06_17_156679	17	12	also	also	RB
10_1101-2020_06_17_156679	17	13	known	know	VBN
10_1101-2020_06_17_156679	17	14	as	as	IN
10_1101-2020_06_17_156679	17	15	the	the	DT
10_1101-2020_06_17_156679	17	16	viral	viral	JJ
10_1101-2020_06_17_156679	17	17	main	main	JJ
10_1101-2020_06_17_156679	17	18	protease	protease	NN
10_1101-2020_06_17_156679	17	19	(	(	-LRB-
10_1101-2020_06_17_156679	17	20	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	17	21	)	)	-RRB-
10_1101-2020_06_17_156679	17	22	,	,	,
10_1101-2020_06_17_156679	17	23	has	have	VBZ
10_1101-2020_06_17_156679	17	24	been	be	VBN
10_1101-2020_06_17_156679	17	25	the	the	DT
10_1101-2020_06_17_156679	17	26	44	44	CD
10_1101-2020_06_17_156679	17	27	target	target	NN
10_1101-2020_06_17_156679	17	28	of	of	IN
10_1101-2020_06_17_156679	17	29	intense	intense	JJ
10_1101-2020_06_17_156679	17	30	study	study	NN
10_1101-2020_06_17_156679	17	31	owing	owe	VBG
10_1101-2020_06_17_156679	17	32	to	to	IN
10_1101-2020_06_17_156679	17	33	its	-PRON-	PRP$
10_1101-2020_06_17_156679	17	34	centrality	centrality	NN
10_1101-2020_06_17_156679	17	35	in	in	IN
10_1101-2020_06_17_156679	17	36	viral	viral	JJ
10_1101-2020_06_17_156679	17	37	replication	replication	NN
10_1101-2020_06_17_156679	17	38	.	.	.
10_1101-2020_06_17_156679	18	1	Mpro	mpro	JJ
10_1101-2020_06_17_156679	18	2	studies	study	NNS
10_1101-2020_06_17_156679	18	3	have	have	VBP
10_1101-2020_06_17_156679	18	4	benefited	benefit	VBN
10_1101-2020_06_17_156679	18	5	from	from	IN
10_1101-2020_06_17_156679	18	6	45	45	CD
10_1101-2020_06_17_156679	18	7	previous	previous	JJ
10_1101-2020_06_17_156679	18	8	structural	structural	JJ
10_1101-2020_06_17_156679	18	9	analyses	analysis	NNS
10_1101-2020_06_17_156679	18	10	of	of	IN
10_1101-2020_06_17_156679	18	11	the	the	DT
10_1101-2020_06_17_156679	18	12	SARC	SARC	NNP
10_1101-2020_06_17_156679	18	13	-	-	HYPH
10_1101-2020_06_17_156679	18	14	CoV	CoV	NNP
10_1101-2020_06_17_156679	18	15	3C	3c	NN
10_1101-2020_06_17_156679	18	16	-	-	HYPH
10_1101-2020_06_17_156679	18	17	like	like	JJ
10_1101-2020_06_17_156679	18	18	protease	protease	NN
10_1101-2020_06_17_156679	18	19	and	and	CC
10_1101-2020_06_17_156679	18	20	the	the	DT
10_1101-2020_06_17_156679	18	21	earlier	early	JJR
10_1101-2020_06_17_156679	18	22	development	development	NN
10_1101-2020_06_17_156679	18	23	of	of	IN
10_1101-2020_06_17_156679	18	24	46	46	CD
10_1101-2020_06_17_156679	18	25	putative	putative	JJ
10_1101-2020_06_17_156679	18	26	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	18	27	(	(	-LRB-
10_1101-2020_06_17_156679	18	28	11	11	CD
10_1101-2020_06_17_156679	18	29	-	-	SYM
10_1101-2020_06_17_156679	18	30	14	14	CD
10_1101-2020_06_17_156679	18	31	)	)	-RRB-
10_1101-2020_06_17_156679	18	32	.	.	.
10_1101-2020_06_17_156679	19	1	The	the	DT
10_1101-2020_06_17_156679	19	2	active	active	JJ
10_1101-2020_06_17_156679	19	3	sites	site	NNS
10_1101-2020_06_17_156679	19	4	of	of	IN
10_1101-2020_06_17_156679	19	5	these	these	DT
10_1101-2020_06_17_156679	19	6	proteases	protease	NNS
10_1101-2020_06_17_156679	19	7	are	be	VBP
10_1101-2020_06_17_156679	19	8	highly	highly	RB
10_1101-2020_06_17_156679	19	9	conserved	conserve	VBN
10_1101-2020_06_17_156679	19	10	,	,	,
10_1101-2020_06_17_156679	19	11	and	and	CC
10_1101-2020_06_17_156679	19	12	47	47	CD
10_1101-2020_06_17_156679	19	13	peptidomimetic	peptidomimetic	JJ
10_1101-2020_06_17_156679	19	14	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	19	15	active	active	JJ
10_1101-2020_06_17_156679	19	16	against	against	IN
10_1101-2020_06_17_156679	19	17	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	19	18	are	be	VBP
10_1101-2020_06_17_156679	19	19	also	also	RB
10_1101-2020_06_17_156679	19	20	potent	potent	JJ
10_1101-2020_06_17_156679	19	21	against	against	IN
10_1101-2020_06_17_156679	19	22	the	the	DT
10_1101-2020_06_17_156679	19	23	SARS	SARS	NNP
10_1101-2020_06_17_156679	19	24	-	-	HYPH
10_1101-2020_06_17_156679	19	25	CoV	CoV	NNP
10_1101-2020_06_17_156679	19	26	3C	3c	NN
10_1101-2020_06_17_156679	19	27	-	-	HYPH
10_1101-2020_06_17_156679	19	28	like	like	JJ
10_1101-2020_06_17_156679	19	29	protease	protease	NN
10_1101-2020_06_17_156679	19	30	48	48	CD
10_1101-2020_06_17_156679	19	31	(	(	-LRB-
10_1101-2020_06_17_156679	19	32	15	15	CD
10_1101-2020_06_17_156679	19	33	,	,	,
10_1101-2020_06_17_156679	19	34	16	16	CD
10_1101-2020_06_17_156679	19	35	)	)	-RRB-
10_1101-2020_06_17_156679	19	36	.	.	.
10_1101-2020_06_17_156679	20	1	However	however	RB
10_1101-2020_06_17_156679	20	2	,	,	,
10_1101-2020_06_17_156679	20	3	to	to	IN
10_1101-2020_06_17_156679	20	4	date	date	NN
10_1101-2020_06_17_156679	20	5	no	no	DT
10_1101-2020_06_17_156679	20	6	Mpro	mpro	NN
10_1101-2020_06_17_156679	20	7	-	-	HYPH
10_1101-2020_06_17_156679	20	8	targeting	target	VBG
10_1101-2020_06_17_156679	20	9	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	20	10	have	have	VBP
10_1101-2020_06_17_156679	20	11	been	be	VBN
10_1101-2020_06_17_156679	20	12	validated	validate	VBN
10_1101-2020_06_17_156679	20	13	in	in	IN
10_1101-2020_06_17_156679	20	14	clinical	clinical	JJ
10_1101-2020_06_17_156679	20	15	trials	trial	NNS
10_1101-2020_06_17_156679	20	16	.	.	.
10_1101-2020_06_17_156679	21	1	In	in	IN
10_1101-2020_06_17_156679	21	2	order	order	NN
10_1101-2020_06_17_156679	21	3	49	49	CD
10_1101-2020_06_17_156679	21	4	to	to	TO
10_1101-2020_06_17_156679	21	5	accelerate	accelerate	VB
10_1101-2020_06_17_156679	21	6	Mpro	mpro	JJ
10_1101-2020_06_17_156679	21	7	inhibitor	inhibitor	NN
10_1101-2020_06_17_156679	21	8	development	development	NN
10_1101-2020_06_17_156679	21	9	,	,	,
10_1101-2020_06_17_156679	21	10	an	an	DT
10_1101-2020_06_17_156679	21	11	international	international	JJ
10_1101-2020_06_17_156679	21	12	,	,	,
10_1101-2020_06_17_156679	21	13	crowd	crowd	NN
10_1101-2020_06_17_156679	21	14	-	-	HYPH
10_1101-2020_06_17_156679	21	15	funded	fund	VBN
10_1101-2020_06_17_156679	21	16	,	,	,
10_1101-2020_06_17_156679	21	17	open	open	JJ
10_1101-2020_06_17_156679	21	18	-	-	HYPH
10_1101-2020_06_17_156679	21	19	science	science	NN
10_1101-2020_06_17_156679	21	20	project	project	NN
10_1101-2020_06_17_156679	21	21	was	be	VBD
10_1101-2020_06_17_156679	21	22	50	50	CD
10_1101-2020_06_17_156679	21	23	formed	form	VBN
10_1101-2020_06_17_156679	21	24	under	under	IN
10_1101-2020_06_17_156679	21	25	the	the	DT
10_1101-2020_06_17_156679	21	26	banner	banner	NN
10_1101-2020_06_17_156679	21	27	of	of	IN
10_1101-2020_06_17_156679	21	28	COVID	COVID	NNP
10_1101-2020_06_17_156679	21	29	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	21	30	(	(	-LRB-
10_1101-2020_06_17_156679	21	31	17	17	CD
10_1101-2020_06_17_156679	21	32	)	)	-RRB-
10_1101-2020_06_17_156679	21	33	,	,	,
10_1101-2020_06_17_156679	21	34	combining	combine	VBG
10_1101-2020_06_17_156679	21	35	high	high	JJ
10_1101-2020_06_17_156679	21	36	-	-	HYPH
10_1101-2020_06_17_156679	21	37	throughput	throughput	NN
10_1101-2020_06_17_156679	21	38	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	21	39	51	51	CD
10_1101-2020_06_17_156679	21	40	screening	screening	NN
10_1101-2020_06_17_156679	21	41	(	(	-LRB-
10_1101-2020_06_17_156679	21	42	18	18	CD
10_1101-2020_06_17_156679	21	43	)	)	-RRB-
10_1101-2020_06_17_156679	21	44	,	,	,
10_1101-2020_06_17_156679	21	45	computational	computational	JJ
10_1101-2020_06_17_156679	21	46	chemistry	chemistry	NN
10_1101-2020_06_17_156679	21	47	,	,	,
10_1101-2020_06_17_156679	21	48	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	21	49	activity	activity	NN
10_1101-2020_06_17_156679	21	50	assays	assay	NNS
10_1101-2020_06_17_156679	21	51	and	and	CC
10_1101-2020_06_17_156679	21	52	mass	mass	JJ
10_1101-2020_06_17_156679	21	53	spectroscopy	spectroscopy	NN
10_1101-2020_06_17_156679	21	54	(	(	-LRB-
10_1101-2020_06_17_156679	21	55	19	19	CD
10_1101-2020_06_17_156679	21	56	)	)	-RRB-
10_1101-2020_06_17_156679	21	57	52	52	CD
10_1101-2020_06_17_156679	21	58	among	among	IN
10_1101-2020_06_17_156679	21	59	the	the	DT
10_1101-2020_06_17_156679	21	60	many	many	JJ
10_1101-2020_06_17_156679	21	61	methodologies	methodology	NNS
10_1101-2020_06_17_156679	21	62	contributed	contribute	VBN
10_1101-2020_06_17_156679	21	63	by	by	IN
10_1101-2020_06_17_156679	21	64	collaborating	collaborate	VBG
10_1101-2020_06_17_156679	21	65	groups	group	NNS
10_1101-2020_06_17_156679	21	66	.	.	.
10_1101-2020_06_17_156679	22	1	53	53	CD
10_1101-2020_06_17_156679	22	2	As	as	IN
10_1101-2020_06_17_156679	22	3	part	part	NN
10_1101-2020_06_17_156679	22	4	of	of	IN
10_1101-2020_06_17_156679	22	5	COVID	COVID	NNP
10_1101-2020_06_17_156679	22	6	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	22	7	,	,	,
10_1101-2020_06_17_156679	22	8	we	-PRON-	PRP
10_1101-2020_06_17_156679	22	9	utilised	utilise	VBD
10_1101-2020_06_17_156679	22	10	saturation	saturation	NN
10_1101-2020_06_17_156679	22	11	transfer	transfer	NN
10_1101-2020_06_17_156679	22	12	difference	difference	NN
10_1101-2020_06_17_156679	22	13	nuclear	nuclear	NNP
10_1101-2020_06_17_156679	22	14	magnetic	magnetic	JJ
10_1101-2020_06_17_156679	22	15	54	54	CD
10_1101-2020_06_17_156679	22	16	resonance	resonance	NN
10_1101-2020_06_17_156679	22	17	(	(	-LRB-
10_1101-2020_06_17_156679	22	18	STD	STD	NNP
10_1101-2020_06_17_156679	22	19	-	-	HYPH
10_1101-2020_06_17_156679	22	20	NMR	NMR	NNP
10_1101-2020_06_17_156679	22	21	)	)	-RRB-
10_1101-2020_06_17_156679	22	22	spectroscopy	spectroscopy	NN
10_1101-2020_06_17_156679	22	23	(	(	-LRB-
10_1101-2020_06_17_156679	22	24	20	20	CD
10_1101-2020_06_17_156679	22	25	-	-	SYM
10_1101-2020_06_17_156679	22	26	22	22	CD
10_1101-2020_06_17_156679	22	27	)	)	-RRB-
10_1101-2020_06_17_156679	22	28	to	to	TO
10_1101-2020_06_17_156679	22	29	investigate	investigate	VB
10_1101-2020_06_17_156679	22	30	the	the	DT
10_1101-2020_06_17_156679	22	31	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	22	32	binding	binding	NN
10_1101-2020_06_17_156679	22	33	of	of	IN
10_1101-2020_06_17_156679	22	34	ligands	ligand	NNS
10_1101-2020_06_17_156679	22	35	initially	initially	RB
10_1101-2020_06_17_156679	22	36	55	55	CD
10_1101-2020_06_17_156679	22	37	identified	identify	VBN
10_1101-2020_06_17_156679	22	38	by	by	IN
10_1101-2020_06_17_156679	22	39	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	22	40	screening	screening	NN
10_1101-2020_06_17_156679	22	41	,	,	,
10_1101-2020_06_17_156679	22	42	as	as	RB
10_1101-2020_06_17_156679	22	43	well	well	RB
10_1101-2020_06_17_156679	22	44	as	as	IN
10_1101-2020_06_17_156679	22	45	molecules	molecule	NNS
10_1101-2020_06_17_156679	22	46	designed	design	VBN
10_1101-2020_06_17_156679	22	47	specifically	specifically	RB
10_1101-2020_06_17_156679	22	48	as	as	IN
10_1101-2020_06_17_156679	22	49	non	non	JJ
10_1101-2020_06_17_156679	22	50	-	-	JJ
10_1101-2020_06_17_156679	22	51	covalent	covalent	JJ
10_1101-2020_06_17_156679	22	52	56	56	CD
10_1101-2020_06_17_156679	22	53	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	22	54	of	of	IN
10_1101-2020_06_17_156679	22	55	this	this	DT
10_1101-2020_06_17_156679	22	56	protease	protease	NN
10_1101-2020_06_17_156679	22	57	.	.	.
10_1101-2020_06_17_156679	23	1	Our	-PRON-	PRP$
10_1101-2020_06_17_156679	23	2	goal	goal	NN
10_1101-2020_06_17_156679	23	3	was	be	VBD
10_1101-2020_06_17_156679	23	4	to	to	TO
10_1101-2020_06_17_156679	23	5	provide	provide	VB
10_1101-2020_06_17_156679	23	6	orthogonal	orthogonal	JJ
10_1101-2020_06_17_156679	23	7	information	information	NN
10_1101-2020_06_17_156679	23	8	on	on	IN
10_1101-2020_06_17_156679	23	9	ligand	ligand	NNP
10_1101-2020_06_17_156679	23	10	binding	bind	VBG
10_1101-2020_06_17_156679	23	11	to	to	IN
10_1101-2020_06_17_156679	23	12	that	that	DT
10_1101-2020_06_17_156679	23	13	57	57	CD
10_1101-2020_06_17_156679	23	14	which	which	WDT
10_1101-2020_06_17_156679	23	15	could	could	MD
10_1101-2020_06_17_156679	23	16	be	be	VB
10_1101-2020_06_17_156679	23	17	gained	gain	VBN
10_1101-2020_06_17_156679	23	18	by	by	IN
10_1101-2020_06_17_156679	23	19	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	23	20	activity	activity	NN
10_1101-2020_06_17_156679	23	21	assays	assay	NNS
10_1101-2020_06_17_156679	23	22	conducted	conduct	VBN
10_1101-2020_06_17_156679	23	23	in	in	IN
10_1101-2020_06_17_156679	23	24	parallel	parallel	NN
10_1101-2020_06_17_156679	23	25	by	by	IN
10_1101-2020_06_17_156679	23	26	other	other	JJ
10_1101-2020_06_17_156679	23	27	groups	group	NNS
10_1101-2020_06_17_156679	23	28	.	.	.
10_1101-2020_06_17_156679	24	1	STD	STD	NNP
10_1101-2020_06_17_156679	24	2	-	-	HYPH
10_1101-2020_06_17_156679	24	3	NMR	NMR	NNP
10_1101-2020_06_17_156679	24	4	58	58	CD
10_1101-2020_06_17_156679	24	5	is	be	VBZ
10_1101-2020_06_17_156679	24	6	a	a	DT
10_1101-2020_06_17_156679	24	7	proven	prove	VBN
10_1101-2020_06_17_156679	24	8	method	method	NN
10_1101-2020_06_17_156679	24	9	for	for	IN
10_1101-2020_06_17_156679	24	10	characterising	characterise	VBG
10_1101-2020_06_17_156679	24	11	the	the	DT
10_1101-2020_06_17_156679	24	12	binding	binding	NN
10_1101-2020_06_17_156679	24	13	of	of	IN
10_1101-2020_06_17_156679	24	14	small	small	JJ
10_1101-2020_06_17_156679	24	15	molecules	molecule	NNS
10_1101-2020_06_17_156679	24	16	to	to	IN
10_1101-2020_06_17_156679	24	17	biological	biological	JJ
10_1101-2020_06_17_156679	24	18	macromolecules	macromolecule	NNS
10_1101-2020_06_17_156679	24	19	,	,	,
10_1101-2020_06_17_156679	24	20	59	59	CD
10_1101-2020_06_17_156679	24	21	able	able	JJ
10_1101-2020_06_17_156679	24	22	to	to	TO
10_1101-2020_06_17_156679	24	23	provide	provide	VB
10_1101-2020_06_17_156679	24	24	both	both	DT
10_1101-2020_06_17_156679	24	25	quantitative	quantitative	JJ
10_1101-2020_06_17_156679	24	26	affinity	affinity	NN
10_1101-2020_06_17_156679	24	27	information	information	NN
10_1101-2020_06_17_156679	24	28	and	and	CC
10_1101-2020_06_17_156679	24	29	structural	structural	JJ
10_1101-2020_06_17_156679	24	30	data	datum	NNS
10_1101-2020_06_17_156679	24	31	on	on	IN
10_1101-2020_06_17_156679	24	32	the	the	DT
10_1101-2020_06_17_156679	24	33	proximity	proximity	NN
10_1101-2020_06_17_156679	24	34	of	of	IN
10_1101-2020_06_17_156679	24	35	ligand	ligand	NN
10_1101-2020_06_17_156679	24	36	60	60	CD
10_1101-2020_06_17_156679	24	37	chemical	chemical	NN
10_1101-2020_06_17_156679	24	38	groups	group	NNS
10_1101-2020_06_17_156679	24	39	to	to	IN
10_1101-2020_06_17_156679	24	40	the	the	DT
10_1101-2020_06_17_156679	24	41	protein	protein	NN
10_1101-2020_06_17_156679	24	42	.	.	.
10_1101-2020_06_17_156679	25	1	Here	here	RB
10_1101-2020_06_17_156679	25	2	,	,	,
10_1101-2020_06_17_156679	25	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	25	4	provide	provide	VBP
10_1101-2020_06_17_156679	25	5	detailed	detailed	JJ
10_1101-2020_06_17_156679	25	6	documentation	documentation	NN
10_1101-2020_06_17_156679	25	7	on	on	IN
10_1101-2020_06_17_156679	25	8	the	the	DT
10_1101-2020_06_17_156679	25	9	NMR	NMR	NNP
10_1101-2020_06_17_156679	25	10	protocols	protocol	NNS
10_1101-2020_06_17_156679	25	11	61	61	CD
10_1101-2020_06_17_156679	25	12	used	use	VBD
10_1101-2020_06_17_156679	25	13	to	to	TO
10_1101-2020_06_17_156679	25	14	record	record	VB
10_1101-2020_06_17_156679	25	15	these	these	DT
10_1101-2020_06_17_156679	25	16	data	datum	NNS
10_1101-2020_06_17_156679	25	17	and	and	CC
10_1101-2020_06_17_156679	25	18	highlight	highlight	VB
10_1101-2020_06_17_156679	25	19	the	the	DT
10_1101-2020_06_17_156679	25	20	advantages	advantage	NNS
10_1101-2020_06_17_156679	25	21	,	,	,
10_1101-2020_06_17_156679	25	22	limitations	limitation	NNS
10_1101-2020_06_17_156679	25	23	and	and	CC
10_1101-2020_06_17_156679	25	24	assumptions	assumption	NNS
10_1101-2020_06_17_156679	25	25	underpinning	underpin	VBG
10_1101-2020_06_17_156679	25	26	62	62	CD
10_1101-2020_06_17_156679	25	27	our	-PRON-	PRP$
10_1101-2020_06_17_156679	25	28	approach	approach	NN
10_1101-2020_06_17_156679	25	29	.	.	.
10_1101-2020_06_17_156679	26	1	Our	-PRON-	PRP$
10_1101-2020_06_17_156679	26	2	aim	aim	NN
10_1101-2020_06_17_156679	26	3	is	be	VBZ
10_1101-2020_06_17_156679	26	4	to	to	TO
10_1101-2020_06_17_156679	26	5	assist	assist	VB
10_1101-2020_06_17_156679	26	6	the	the	DT
10_1101-2020_06_17_156679	26	7	comparison	comparison	NN
10_1101-2020_06_17_156679	26	8	of	of	IN
10_1101-2020_06_17_156679	26	9	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	26	10	STD	STD	NNP
10_1101-2020_06_17_156679	26	11	-	-	HYPH
10_1101-2020_06_17_156679	26	12	NMR	NMR	NNP
10_1101-2020_06_17_156679	26	13	data	datum	NNS
10_1101-2020_06_17_156679	26	14	with	with	IN
10_1101-2020_06_17_156679	26	15	other	other	JJ
10_1101-2020_06_17_156679	26	16	quantitative	quantitative	JJ
10_1101-2020_06_17_156679	26	17	63	63	CD
10_1101-2020_06_17_156679	26	18	measurements	measurement	NNS
10_1101-2020_06_17_156679	26	19	,	,	,
10_1101-2020_06_17_156679	26	20	and	and	CC
10_1101-2020_06_17_156679	26	21	facilitate	facilitate	VB
10_1101-2020_06_17_156679	26	22	the	the	DT
10_1101-2020_06_17_156679	26	23	consideration	consideration	NN
10_1101-2020_06_17_156679	26	24	of	of	IN
10_1101-2020_06_17_156679	26	25	these	these	DT
10_1101-2020_06_17_156679	26	26	data	datum	NNS
10_1101-2020_06_17_156679	26	27	when	when	WRB
10_1101-2020_06_17_156679	26	28	designing	design	VBG
10_1101-2020_06_17_156679	26	29	future	future	JJ
10_1101-2020_06_17_156679	26	30	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	26	31	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	26	32	.	.	.
10_1101-2020_06_17_156679	27	1	64	64	CD
10_1101-2020_06_17_156679	27	2	.CC	.CC	NFP
10_1101-2020_06_17_156679	27	3	-	-	:
10_1101-2020_06_17_156679	27	4	BY	by	IN
10_1101-2020_06_17_156679	27	5	4.0	4.0	CD
10_1101-2020_06_17_156679	27	6	International	International	NNP
10_1101-2020_06_17_156679	27	7	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	27	8	under	under	IN
10_1101-2020_06_17_156679	27	9	a	a	DT
10_1101-2020_06_17_156679	27	10	(	(	-LRB-
10_1101-2020_06_17_156679	27	11	which	which	WDT
10_1101-2020_06_17_156679	27	12	was	be	VBD
10_1101-2020_06_17_156679	27	13	not	not	RB
10_1101-2020_06_17_156679	27	14	certified	certify	VBN
10_1101-2020_06_17_156679	27	15	by	by	IN
10_1101-2020_06_17_156679	27	16	peer	peer	NN
10_1101-2020_06_17_156679	27	17	review	review	NN
10_1101-2020_06_17_156679	27	18	)	)	-RRB-
10_1101-2020_06_17_156679	27	19	is	be	VBZ
10_1101-2020_06_17_156679	27	20	the	the	DT
10_1101-2020_06_17_156679	27	21	author	author	NN
10_1101-2020_06_17_156679	27	22	/	/	SYM
10_1101-2020_06_17_156679	27	23	funder	funder	NN
10_1101-2020_06_17_156679	27	24	,	,	,
10_1101-2020_06_17_156679	27	25	who	who	WP
10_1101-2020_06_17_156679	27	26	has	have	VBZ
10_1101-2020_06_17_156679	27	27	granted	grant	VBN
10_1101-2020_06_17_156679	27	28	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	27	29	a	a	DT
10_1101-2020_06_17_156679	27	30	license	license	NN
10_1101-2020_06_17_156679	27	31	to	to	TO
10_1101-2020_06_17_156679	27	32	display	display	VB
10_1101-2020_06_17_156679	27	33	the	the	DT
10_1101-2020_06_17_156679	27	34	preprint	preprint	NN
10_1101-2020_06_17_156679	27	35	in	in	IN
10_1101-2020_06_17_156679	27	36	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	27	37	.	.	.
10_1101-2020_06_17_156679	28	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	28	2	is	be	VBZ
10_1101-2020_06_17_156679	28	3	made	make	VBN
10_1101-2020_06_17_156679	28	4	The	the	DT
10_1101-2020_06_17_156679	28	5	copyright	copyright	NN
10_1101-2020_06_17_156679	28	6	holder	holder	NN
10_1101-2020_06_17_156679	28	7	for	for	IN
10_1101-2020_06_17_156679	28	8	this	this	DT
10_1101-2020_06_17_156679	28	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	28	10	version	version	NN
10_1101-2020_06_17_156679	28	11	posted	post	VBD
10_1101-2020_06_17_156679	28	12	January	January	NNP
10_1101-2020_06_17_156679	28	13	6	6	CD
10_1101-2020_06_17_156679	28	14	,	,	,
10_1101-2020_06_17_156679	28	15	2021	2021	CD
10_1101-2020_06_17_156679	28	16	.	.	.
10_1101-2020_06_17_156679	28	17	;	;	:
10_1101-2020_06_17_156679	28	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	28	19	:	:	:
10_1101-2020_06_17_156679	28	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	28	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	28	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	28	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	28	24	4	4	CD
10_1101-2020_06_17_156679	28	25	Materials	Materials	NNPS
10_1101-2020_06_17_156679	28	26	and	and	CC
10_1101-2020_06_17_156679	28	27	Methods	method	NNS
10_1101-2020_06_17_156679	28	28	65	65	CD
10_1101-2020_06_17_156679	28	29	Protein	protein	NN
10_1101-2020_06_17_156679	28	30	production	production	NN
10_1101-2020_06_17_156679	28	31	and	and	CC
10_1101-2020_06_17_156679	28	32	purification	purification	NN
10_1101-2020_06_17_156679	28	33	66	66	CD
10_1101-2020_06_17_156679	28	34	We	-PRON-	PRP
10_1101-2020_06_17_156679	28	35	created	create	VBD
10_1101-2020_06_17_156679	28	36	a	a	DT
10_1101-2020_06_17_156679	28	37	SARS	SARS	NNP
10_1101-2020_06_17_156679	28	38	-	-	HYPH
10_1101-2020_06_17_156679	28	39	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	28	40	Mpro	mpro	JJ
10_1101-2020_06_17_156679	28	41	genetic	genetic	JJ
10_1101-2020_06_17_156679	28	42	construct	construct	NN
10_1101-2020_06_17_156679	28	43	in	in	IN
10_1101-2020_06_17_156679	28	44	pFLOAT	pfloat	JJ
10_1101-2020_06_17_156679	28	45	vector	vector	NN
10_1101-2020_06_17_156679	28	46	(	(	-LRB-
10_1101-2020_06_17_156679	28	47	23	23	CD
10_1101-2020_06_17_156679	28	48	)	)	-RRB-
10_1101-2020_06_17_156679	28	49	,	,	,
10_1101-2020_06_17_156679	28	50	encoding	encode	VBG
10_1101-2020_06_17_156679	28	51	for	for	IN
10_1101-2020_06_17_156679	28	52	the	the	DT
10_1101-2020_06_17_156679	28	53	viral	viral	JJ
10_1101-2020_06_17_156679	28	54	67	67	CD
10_1101-2020_06_17_156679	28	55	protease	protease	NN
10_1101-2020_06_17_156679	28	56	and	and	CC
10_1101-2020_06_17_156679	28	57	an	an	DT
10_1101-2020_06_17_156679	28	58	N	N	NNP
10_1101-2020_06_17_156679	28	59	-	-	HYPH
10_1101-2020_06_17_156679	28	60	terminal	terminal	NN
10_1101-2020_06_17_156679	28	61	His6-tag	His6-tag	NNP
10_1101-2020_06_17_156679	28	62	separated	separate	VBN
10_1101-2020_06_17_156679	28	63	by	by	IN
10_1101-2020_06_17_156679	28	64	a	a	DT
10_1101-2020_06_17_156679	28	65	modified	modify	VBN
10_1101-2020_06_17_156679	28	66	human	human	NN
10_1101-2020_06_17_156679	28	67	rhinovirus	rhinovirus	NN
10_1101-2020_06_17_156679	28	68	(	(	-LRB-
10_1101-2020_06_17_156679	28	69	HRV	HRV	NNP
10_1101-2020_06_17_156679	28	70	)	)	-RRB-
10_1101-2020_06_17_156679	28	71	3C	3c	NN
10_1101-2020_06_17_156679	28	72	protease	protease	VB
10_1101-2020_06_17_156679	28	73	68	68	CD
10_1101-2020_06_17_156679	28	74	recognition	recognition	NN
10_1101-2020_06_17_156679	28	75	site	site	NN
10_1101-2020_06_17_156679	28	76	,	,	,
10_1101-2020_06_17_156679	28	77	designed	design	VBN
10_1101-2020_06_17_156679	28	78	to	to	TO
10_1101-2020_06_17_156679	28	79	reconstitute	reconstitute	VB
10_1101-2020_06_17_156679	28	80	a	a	DT
10_1101-2020_06_17_156679	28	81	native	native	JJ
10_1101-2020_06_17_156679	28	82	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	28	83	N	N	NNP
10_1101-2020_06_17_156679	28	84	-	-	HYPH
10_1101-2020_06_17_156679	28	85	terminus	terminus	NN
10_1101-2020_06_17_156679	28	86	upon	upon	IN
10_1101-2020_06_17_156679	28	87	HRV	HRV	NNP
10_1101-2020_06_17_156679	28	88	3C	3c	NN
10_1101-2020_06_17_156679	28	89	cleavage	cleavage	NN
10_1101-2020_06_17_156679	28	90	.	.	.
10_1101-2020_06_17_156679	29	1	The	the	DT
10_1101-2020_06_17_156679	29	2	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	29	3	69	69	CD
10_1101-2020_06_17_156679	29	4	construct	construct	NN
10_1101-2020_06_17_156679	29	5	was	be	VBD
10_1101-2020_06_17_156679	29	6	transformed	transform	VBN
10_1101-2020_06_17_156679	29	7	into	into	IN
10_1101-2020_06_17_156679	29	8	Escherichia	Escherichia	NNP
10_1101-2020_06_17_156679	29	9	coli	coli	NNS
10_1101-2020_06_17_156679	29	10	strain	strain	VBP
10_1101-2020_06_17_156679	29	11	Rosetta(DE3	rosetta(de3	ADD
10_1101-2020_06_17_156679	29	12	)	)	-RRB-
10_1101-2020_06_17_156679	29	13	(	(	-LRB-
10_1101-2020_06_17_156679	29	14	Novagen	Novagen	NNP
10_1101-2020_06_17_156679	29	15	)	)	-RRB-
10_1101-2020_06_17_156679	29	16	and	and	CC
10_1101-2020_06_17_156679	29	17	transformed	transform	VBD
10_1101-2020_06_17_156679	29	18	70	70	CD
10_1101-2020_06_17_156679	29	19	clones	clone	NNS
10_1101-2020_06_17_156679	29	20	were	be	VBD
10_1101-2020_06_17_156679	29	21	pre	pre	VBN
10_1101-2020_06_17_156679	29	22	-	-	JJ
10_1101-2020_06_17_156679	29	23	cultured	cultured	JJ
10_1101-2020_06_17_156679	29	24	at	at	IN
10_1101-2020_06_17_156679	29	25	37	37	CD
10_1101-2020_06_17_156679	29	26	°	°	,
10_1101-2020_06_17_156679	29	27	C	C	NNP
10_1101-2020_06_17_156679	29	28	for	for	IN
10_1101-2020_06_17_156679	29	29	5	5	CD
10_1101-2020_06_17_156679	29	30	h	h	NN
10_1101-2020_06_17_156679	29	31	in	in	IN
10_1101-2020_06_17_156679	29	32	lysogeny	lysogeny	JJ
10_1101-2020_06_17_156679	29	33	broth	broth	NN
10_1101-2020_06_17_156679	29	34	supplemented	supplement	VBN
10_1101-2020_06_17_156679	29	35	with	with	IN
10_1101-2020_06_17_156679	29	36	appropriate	appropriate	JJ
10_1101-2020_06_17_156679	29	37	71	71	CD
10_1101-2020_06_17_156679	29	38	antibiotics	antibiotic	NNS
10_1101-2020_06_17_156679	29	39	.	.	.
10_1101-2020_06_17_156679	30	1	Starter	starter	NN
10_1101-2020_06_17_156679	30	2	cultures	culture	NNS
10_1101-2020_06_17_156679	30	3	were	be	VBD
10_1101-2020_06_17_156679	30	4	used	use	VBN
10_1101-2020_06_17_156679	30	5	to	to	TO
10_1101-2020_06_17_156679	30	6	inoculate	inoculate	VB
10_1101-2020_06_17_156679	30	7	1	1	CD
10_1101-2020_06_17_156679	30	8	L	l	NN
10_1101-2020_06_17_156679	30	9	of	of	IN
10_1101-2020_06_17_156679	30	10	Terrific	Terrific	NNP
10_1101-2020_06_17_156679	30	11	Broth	Broth	NNP
10_1101-2020_06_17_156679	30	12	Autoinduction	Autoinduction	NNP
10_1101-2020_06_17_156679	30	13	Media	Media	NNP
10_1101-2020_06_17_156679	30	14	72	72	CD
10_1101-2020_06_17_156679	30	15	(	(	-LRB-
10_1101-2020_06_17_156679	30	16	Formedium	Formedium	NNP
10_1101-2020_06_17_156679	30	17	)	)	-RRB-
10_1101-2020_06_17_156679	30	18	supplemented	supplement	VBD
10_1101-2020_06_17_156679	30	19	with	with	IN
10_1101-2020_06_17_156679	30	20	10	10	CD
10_1101-2020_06_17_156679	30	21	%	%	NN
10_1101-2020_06_17_156679	30	22	v	v	NN
10_1101-2020_06_17_156679	30	23	/	/	SYM
10_1101-2020_06_17_156679	30	24	v	v	NN
10_1101-2020_06_17_156679	30	25	glycerol	glycerol	NN
10_1101-2020_06_17_156679	30	26	and	and	CC
10_1101-2020_06_17_156679	30	27	appropriate	appropriate	JJ
10_1101-2020_06_17_156679	30	28	antibiotics	antibiotic	NNS
10_1101-2020_06_17_156679	30	29	.	.	.
10_1101-2020_06_17_156679	31	1	Cell	cell	NN
10_1101-2020_06_17_156679	31	2	cultures	culture	NNS
10_1101-2020_06_17_156679	31	3	were	be	VBD
10_1101-2020_06_17_156679	31	4	73	73	CD
10_1101-2020_06_17_156679	31	5	grown	grow	VBN
10_1101-2020_06_17_156679	31	6	at	at	IN
10_1101-2020_06_17_156679	31	7	37	37	CD
10_1101-2020_06_17_156679	31	8	°	°	,
10_1101-2020_06_17_156679	31	9	C	C	NNP
10_1101-2020_06_17_156679	31	10	for	for	IN
10_1101-2020_06_17_156679	31	11	5	5	CD
10_1101-2020_06_17_156679	31	12	h	h	NNS
10_1101-2020_06_17_156679	31	13	and	and	CC
10_1101-2020_06_17_156679	31	14	then	then	RB
10_1101-2020_06_17_156679	31	15	cooled	cool	VBD
10_1101-2020_06_17_156679	31	16	to	to	IN
10_1101-2020_06_17_156679	31	17	18	18	CD
10_1101-2020_06_17_156679	31	18	°	°	,
10_1101-2020_06_17_156679	31	19	C	C	NNP
10_1101-2020_06_17_156679	31	20	for	for	IN
10_1101-2020_06_17_156679	31	21	12	12	CD
10_1101-2020_06_17_156679	31	22	h.	h.	NN
10_1101-2020_06_17_156679	31	23	Bacterial	bacterial	JJ
10_1101-2020_06_17_156679	31	24	cells	cell	NNS
10_1101-2020_06_17_156679	31	25	were	be	VBD
10_1101-2020_06_17_156679	31	26	harvested	harvest	VBN
10_1101-2020_06_17_156679	31	27	by	by	IN
10_1101-2020_06_17_156679	31	28	74	74	CD
10_1101-2020_06_17_156679	31	29	centrifugation	centrifugation	NN
10_1101-2020_06_17_156679	31	30	at	at	IN
10_1101-2020_06_17_156679	31	31	5,000	5,000	CD
10_1101-2020_06_17_156679	31	32	x	x	SYM
10_1101-2020_06_17_156679	31	33	g	g	NN
10_1101-2020_06_17_156679	31	34	for	for	IN
10_1101-2020_06_17_156679	31	35	15	15	CD
10_1101-2020_06_17_156679	31	36	min	min	NN
10_1101-2020_06_17_156679	31	37	.	.	.
10_1101-2020_06_17_156679	32	1	75	75	CD
10_1101-2020_06_17_156679	32	2	Cell	Cell	NNP
10_1101-2020_06_17_156679	32	3	pellets	pellet	NNS
10_1101-2020_06_17_156679	32	4	were	be	VBD
10_1101-2020_06_17_156679	32	5	resuspended	resuspend	VBN
10_1101-2020_06_17_156679	32	6	in	in	IN
10_1101-2020_06_17_156679	32	7	50	50	CD
10_1101-2020_06_17_156679	32	8	mM	mm	NN
10_1101-2020_06_17_156679	32	9	trisaminomethane	trisaminomethane	NN
10_1101-2020_06_17_156679	32	10	(	(	-LRB-
10_1101-2020_06_17_156679	32	11	Tris)-Cl	Tris)-Cl	NNP
10_1101-2020_06_17_156679	32	12	pH	pH	NNP
10_1101-2020_06_17_156679	32	13	8	8	CD
10_1101-2020_06_17_156679	32	14	,	,	,
10_1101-2020_06_17_156679	32	15	300	300	CD
10_1101-2020_06_17_156679	32	16	mM	mM	NNP
10_1101-2020_06_17_156679	32	17	NaCl	NaCl	NNP
10_1101-2020_06_17_156679	32	18	,	,	,
10_1101-2020_06_17_156679	32	19	10	10	CD
10_1101-2020_06_17_156679	32	20	mM	mM	NNP
10_1101-2020_06_17_156679	32	21	76	76	CD
10_1101-2020_06_17_156679	32	22	imidazole	imidazole	NN
10_1101-2020_06_17_156679	32	23	buffer	buffer	NN
10_1101-2020_06_17_156679	32	24	,	,	,
10_1101-2020_06_17_156679	32	25	incubated	incubate	VBD
10_1101-2020_06_17_156679	32	26	with	with	IN
10_1101-2020_06_17_156679	32	27	0.05	0.05	CD
10_1101-2020_06_17_156679	32	28	mg	mg	NNP
10_1101-2020_06_17_156679	32	29	/	/	SYM
10_1101-2020_06_17_156679	32	30	ml	ml	NNP
10_1101-2020_06_17_156679	32	31	benzonase	benzonase	NNP
10_1101-2020_06_17_156679	32	32	nuclease	nuclease	NNP
10_1101-2020_06_17_156679	32	33	(	(	-LRB-
10_1101-2020_06_17_156679	32	34	Sigma	Sigma	NNP
10_1101-2020_06_17_156679	32	35	Aldrich	Aldrich	NNP
10_1101-2020_06_17_156679	32	36	)	)	-RRB-
10_1101-2020_06_17_156679	32	37	and	and	CC
10_1101-2020_06_17_156679	32	38	lysed	lyse	VBN
10_1101-2020_06_17_156679	32	39	by	by	IN
10_1101-2020_06_17_156679	32	40	77	77	CD
10_1101-2020_06_17_156679	32	41	sonication	sonication	NN
10_1101-2020_06_17_156679	32	42	on	on	IN
10_1101-2020_06_17_156679	32	43	ice	ice	NN
10_1101-2020_06_17_156679	32	44	.	.	.
10_1101-2020_06_17_156679	33	1	Lysates	lysate	NNS
10_1101-2020_06_17_156679	33	2	were	be	VBD
10_1101-2020_06_17_156679	33	3	clarified	clarify	VBN
10_1101-2020_06_17_156679	33	4	by	by	IN
10_1101-2020_06_17_156679	33	5	centrifugation	centrifugation	NN
10_1101-2020_06_17_156679	33	6	at	at	IN
10_1101-2020_06_17_156679	33	7	50,000	50,000	CD
10_1101-2020_06_17_156679	33	8	x	x	SYM
10_1101-2020_06_17_156679	33	9	g	g	NN
10_1101-2020_06_17_156679	33	10	at	at	IN
10_1101-2020_06_17_156679	33	11	4	4	CD
10_1101-2020_06_17_156679	33	12	°	°	,
10_1101-2020_06_17_156679	33	13	C	C	NNP
10_1101-2020_06_17_156679	33	14	for	for	IN
10_1101-2020_06_17_156679	33	15	1	1	CD
10_1101-2020_06_17_156679	33	16	h.	h.	NN
10_1101-2020_06_17_156679	33	17	Lysate	Lysate	NNP
10_1101-2020_06_17_156679	33	18	78	78	CD
10_1101-2020_06_17_156679	33	19	supernatants	supernatant	NNS
10_1101-2020_06_17_156679	33	20	were	be	VBD
10_1101-2020_06_17_156679	33	21	loaded	load	VBN
10_1101-2020_06_17_156679	33	22	onto	onto	IN
10_1101-2020_06_17_156679	33	23	a	a	DT
10_1101-2020_06_17_156679	33	24	HiTrap	HiTrap	NNP
10_1101-2020_06_17_156679	33	25	Talon	Talon	NNP
10_1101-2020_06_17_156679	33	26	metal	metal	NN
10_1101-2020_06_17_156679	33	27	affinity	affinity	NN
10_1101-2020_06_17_156679	33	28	column	column	NN
10_1101-2020_06_17_156679	33	29	(	(	-LRB-
10_1101-2020_06_17_156679	33	30	GE	GE	NNP
10_1101-2020_06_17_156679	33	31	Healthcare	Healthcare	NNP
10_1101-2020_06_17_156679	33	32	)	)	-RRB-
10_1101-2020_06_17_156679	33	33	pre-79	pre-79	NN
10_1101-2020_06_17_156679	33	34	equilibrated	equilibrate	VBD
10_1101-2020_06_17_156679	33	35	with	with	IN
10_1101-2020_06_17_156679	33	36	lysis	lysis	NN
10_1101-2020_06_17_156679	33	37	buffer	buffer	NN
10_1101-2020_06_17_156679	33	38	.	.	.
10_1101-2020_06_17_156679	34	1	Column	column	NN
10_1101-2020_06_17_156679	34	2	wash	wash	NN
10_1101-2020_06_17_156679	34	3	was	be	VBD
10_1101-2020_06_17_156679	34	4	performed	perform	VBN
10_1101-2020_06_17_156679	34	5	with	with	IN
10_1101-2020_06_17_156679	34	6	50	50	CD
10_1101-2020_06_17_156679	34	7	mM	mM	NNP
10_1101-2020_06_17_156679	34	8	Tris	Tris	NNP
10_1101-2020_06_17_156679	34	9	-	-	HYPH
10_1101-2020_06_17_156679	34	10	Cl	Cl	NNP
10_1101-2020_06_17_156679	34	11	pH	pH	NNP
10_1101-2020_06_17_156679	34	12	8	8	CD
10_1101-2020_06_17_156679	34	13	,	,	,
10_1101-2020_06_17_156679	34	14	300	300	CD
10_1101-2020_06_17_156679	34	15	mM	mm	NN
10_1101-2020_06_17_156679	34	16	NaCl	NaCl	NNP
10_1101-2020_06_17_156679	34	17	80	80	CD
10_1101-2020_06_17_156679	34	18	and	and	CC
10_1101-2020_06_17_156679	34	19	25	25	CD
10_1101-2020_06_17_156679	34	20	mM	mM	NNP
10_1101-2020_06_17_156679	34	21	imidazole	imidazole	NN
10_1101-2020_06_17_156679	34	22	,	,	,
10_1101-2020_06_17_156679	34	23	followed	follow	VBN
10_1101-2020_06_17_156679	34	24	by	by	IN
10_1101-2020_06_17_156679	34	25	protein	protein	NN
10_1101-2020_06_17_156679	34	26	elution	elution	NN
10_1101-2020_06_17_156679	34	27	using	use	VBG
10_1101-2020_06_17_156679	34	28	the	the	DT
10_1101-2020_06_17_156679	34	29	same	same	JJ
10_1101-2020_06_17_156679	34	30	buffer	buffer	NN
10_1101-2020_06_17_156679	34	31	and	and	CC
10_1101-2020_06_17_156679	34	32	an	an	DT
10_1101-2020_06_17_156679	34	33	imidazole	imidazole	NN
10_1101-2020_06_17_156679	34	34	gradient	gradient	NN
10_1101-2020_06_17_156679	34	35	81	81	CD
10_1101-2020_06_17_156679	34	36	from	from	IN
10_1101-2020_06_17_156679	34	37	25	25	CD
10_1101-2020_06_17_156679	34	38	to	to	TO
10_1101-2020_06_17_156679	34	39	500	500	CD
10_1101-2020_06_17_156679	34	40	mM	mm	NN
10_1101-2020_06_17_156679	34	41	concentration	concentration	NN
10_1101-2020_06_17_156679	34	42	.	.	.
10_1101-2020_06_17_156679	35	1	The	the	DT
10_1101-2020_06_17_156679	35	2	His6-tag	His6-tag	NNP
10_1101-2020_06_17_156679	35	3	was	be	VBD
10_1101-2020_06_17_156679	35	4	cleaved	cleave	VBN
10_1101-2020_06_17_156679	35	5	using	use	VBG
10_1101-2020_06_17_156679	35	6	home	home	NN
10_1101-2020_06_17_156679	35	7	-	-	HYPH
10_1101-2020_06_17_156679	35	8	made	make	VBN
10_1101-2020_06_17_156679	35	9	HRV	HRV	NNP
10_1101-2020_06_17_156679	35	10	3C	3c	NN
10_1101-2020_06_17_156679	35	11	protease	protease	VB
10_1101-2020_06_17_156679	35	12	.	.	.
10_1101-2020_06_17_156679	36	1	The	the	DT
10_1101-2020_06_17_156679	36	2	82	82	CD
10_1101-2020_06_17_156679	36	3	HRV	HRV	NNP
10_1101-2020_06_17_156679	36	4	3C	3c	NN
10_1101-2020_06_17_156679	36	5	protease	protease	VB
10_1101-2020_06_17_156679	36	6	,	,	,
10_1101-2020_06_17_156679	36	7	His6-tag	His6-tag	NNP
10_1101-2020_06_17_156679	36	8	and	and	CC
10_1101-2020_06_17_156679	36	9	further	further	JJ
10_1101-2020_06_17_156679	36	10	impurities	impurity	NNS
10_1101-2020_06_17_156679	36	11	were	be	VBD
10_1101-2020_06_17_156679	36	12	removed	remove	VBN
10_1101-2020_06_17_156679	36	13	by	by	IN
10_1101-2020_06_17_156679	36	14	a	a	DT
10_1101-2020_06_17_156679	36	15	reverse	reverse	JJ
10_1101-2020_06_17_156679	36	16	HiTrap	HiTrap	NNP
10_1101-2020_06_17_156679	36	17	Talon	Talon	NNP
10_1101-2020_06_17_156679	36	18	column	column	NN
10_1101-2020_06_17_156679	36	19	.	.	.
10_1101-2020_06_17_156679	37	1	83	83	CD
10_1101-2020_06_17_156679	37	2	Flow	flow	NN
10_1101-2020_06_17_156679	37	3	-	-	HYPH
10_1101-2020_06_17_156679	37	4	through	through	RP
10_1101-2020_06_17_156679	37	5	fractions	fraction	NNS
10_1101-2020_06_17_156679	37	6	were	be	VBD
10_1101-2020_06_17_156679	37	7	concentrated	concentrate	VBN
10_1101-2020_06_17_156679	37	8	and	and	CC
10_1101-2020_06_17_156679	37	9	applied	apply	VBN
10_1101-2020_06_17_156679	37	10	to	to	IN
10_1101-2020_06_17_156679	37	11	a	a	DT
10_1101-2020_06_17_156679	37	12	Superdex75	Superdex75	NNP
10_1101-2020_06_17_156679	37	13	26/600	26/600	CD
10_1101-2020_06_17_156679	37	14	size	size	NN
10_1101-2020_06_17_156679	37	15	exclusion	exclusion	NN
10_1101-2020_06_17_156679	37	16	84	84	CD
10_1101-2020_06_17_156679	37	17	column	column	NN
10_1101-2020_06_17_156679	37	18	(	(	-LRB-
10_1101-2020_06_17_156679	37	19	GE	GE	NNP
10_1101-2020_06_17_156679	37	20	Healthcare	Healthcare	NNP
10_1101-2020_06_17_156679	37	21	)	)	-RRB-
10_1101-2020_06_17_156679	37	22	equilibrated	equilibrate	VBN
10_1101-2020_06_17_156679	37	23	in	in	IN
10_1101-2020_06_17_156679	37	24	NMR	NMR	NNP
10_1101-2020_06_17_156679	37	25	buffer	buffer	NNP
10_1101-2020_06_17_156679	37	26	(	(	-LRB-
10_1101-2020_06_17_156679	37	27	150	150	CD
10_1101-2020_06_17_156679	37	28	mM	mM	NNP
10_1101-2020_06_17_156679	37	29	NaCl	NaCl	NNP
10_1101-2020_06_17_156679	37	30	,	,	,
10_1101-2020_06_17_156679	37	31	20	20	CD
10_1101-2020_06_17_156679	37	32	mM	mM	NNP
10_1101-2020_06_17_156679	37	33	Na2HPO4	Na2HPO4	NNP
10_1101-2020_06_17_156679	37	34	pH	pH	NNP
10_1101-2020_06_17_156679	37	35	7.4	7.4	CD
10_1101-2020_06_17_156679	37	36	)	)	-RRB-
10_1101-2020_06_17_156679	37	37	.	.	.
10_1101-2020_06_17_156679	38	1	85	85	CD
10_1101-2020_06_17_156679	38	2	86	86	CD
10_1101-2020_06_17_156679	38	3	Nuclear	nuclear	JJ
10_1101-2020_06_17_156679	38	4	magnetic	magnetic	JJ
10_1101-2020_06_17_156679	38	5	resonance	resonance	NN
10_1101-2020_06_17_156679	38	6	(	(	-LRB-
10_1101-2020_06_17_156679	38	7	NMR	NMR	NNP
10_1101-2020_06_17_156679	38	8	)	)	-RRB-
10_1101-2020_06_17_156679	38	9	spectroscopy	spectroscopy	VBP
10_1101-2020_06_17_156679	38	10	87	87	CD
10_1101-2020_06_17_156679	38	11	All	all	DT
10_1101-2020_06_17_156679	38	12	NMR	NMR	NNP
10_1101-2020_06_17_156679	38	13	experiments	experiment	NNS
10_1101-2020_06_17_156679	38	14	were	be	VBD
10_1101-2020_06_17_156679	38	15	performed	perform	VBN
10_1101-2020_06_17_156679	38	16	using	use	VBG
10_1101-2020_06_17_156679	38	17	a	a	DT
10_1101-2020_06_17_156679	38	18	950	950	CD
10_1101-2020_06_17_156679	38	19	MHz	MHz	NNS
10_1101-2020_06_17_156679	38	20	solution	solution	NN
10_1101-2020_06_17_156679	38	21	-	-	HYPH
10_1101-2020_06_17_156679	38	22	state	state	NN
10_1101-2020_06_17_156679	38	23	instrument	instrument	NN
10_1101-2020_06_17_156679	38	24	comprising	comprise	VBG
10_1101-2020_06_17_156679	38	25	an	an	DT
10_1101-2020_06_17_156679	38	26	88	88	CD
10_1101-2020_06_17_156679	38	27	Oxford	Oxford	NNP
10_1101-2020_06_17_156679	38	28	Instruments	Instruments	NNPS
10_1101-2020_06_17_156679	38	29	superconducting	superconducte	VBG
10_1101-2020_06_17_156679	38	30	magnet	magnet	NN
10_1101-2020_06_17_156679	38	31	,	,	,
10_1101-2020_06_17_156679	38	32	Bruker	Bruker	NNP
10_1101-2020_06_17_156679	38	33	Avance	Avance	NNP
10_1101-2020_06_17_156679	38	34	III	iii	CD
10_1101-2020_06_17_156679	38	35	console	console	NN
10_1101-2020_06_17_156679	38	36	and	and	CC
10_1101-2020_06_17_156679	38	37	TCI	TCI	NNP
10_1101-2020_06_17_156679	38	38	probehead	probehead	NN
10_1101-2020_06_17_156679	38	39	.	.	.
10_1101-2020_06_17_156679	39	1	A	a	DT
10_1101-2020_06_17_156679	39	2	Bruker	Bruker	NNP
10_1101-2020_06_17_156679	39	3	89	89	CD
10_1101-2020_06_17_156679	39	4	SampleJet	SampleJet	NNP
10_1101-2020_06_17_156679	39	5	sample	sample	NN
10_1101-2020_06_17_156679	39	6	changer	changer	NN
10_1101-2020_06_17_156679	39	7	was	be	VBD
10_1101-2020_06_17_156679	39	8	used	use	VBN
10_1101-2020_06_17_156679	39	9	for	for	IN
10_1101-2020_06_17_156679	39	10	sample	sample	NN
10_1101-2020_06_17_156679	39	11	manipulation	manipulation	NN
10_1101-2020_06_17_156679	39	12	.	.	.
10_1101-2020_06_17_156679	40	1	Experiments	experiment	NNS
10_1101-2020_06_17_156679	40	2	were	be	VBD
10_1101-2020_06_17_156679	40	3	performed	perform	VBN
10_1101-2020_06_17_156679	40	4	and	and	CC
10_1101-2020_06_17_156679	40	5	90	90	CD
10_1101-2020_06_17_156679	40	6	data	datum	NNS
10_1101-2020_06_17_156679	40	7	processed	process	VBN
10_1101-2020_06_17_156679	40	8	using	use	VBG
10_1101-2020_06_17_156679	40	9	TopSpin	TopSpin	NNP
10_1101-2020_06_17_156679	40	10	(	(	-LRB-
10_1101-2020_06_17_156679	40	11	Bruker	Bruker	NNP
10_1101-2020_06_17_156679	40	12	)	)	-RRB-
10_1101-2020_06_17_156679	40	13	.	.	.
10_1101-2020_06_17_156679	41	1	For	for	IN
10_1101-2020_06_17_156679	41	2	direct	direct	JJ
10_1101-2020_06_17_156679	41	3	STD	STD	NNP
10_1101-2020_06_17_156679	41	4	-	-	HYPH
10_1101-2020_06_17_156679	41	5	NMR	NMR	NNP
10_1101-2020_06_17_156679	41	6	measurements	measurement	NNS
10_1101-2020_06_17_156679	41	7	,	,	,
10_1101-2020_06_17_156679	41	8	samples	sample	NNS
10_1101-2020_06_17_156679	41	9	comprised	comprise	VBD
10_1101-2020_06_17_156679	41	10	10	10	CD
10_1101-2020_06_17_156679	41	11	91	91	CD
10_1101-2020_06_17_156679	41	12	μM	μM	NNP
10_1101-2020_06_17_156679	41	13	Mpro	mpro	JJ
10_1101-2020_06_17_156679	41	14	and	and	CC
10_1101-2020_06_17_156679	41	15	variable	variable	JJ
10_1101-2020_06_17_156679	41	16	concentrations	concentration	NNS
10_1101-2020_06_17_156679	41	17	(	(	-LRB-
10_1101-2020_06_17_156679	41	18	20	20	CD
10_1101-2020_06_17_156679	41	19	μM	μm	NN
10_1101-2020_06_17_156679	41	20	–	–	:
10_1101-2020_06_17_156679	41	21	4	4	CD
10_1101-2020_06_17_156679	41	22	mM	mM	NNP
10_1101-2020_06_17_156679	41	23	)	)	-RRB-
10_1101-2020_06_17_156679	41	24	of	of	IN
10_1101-2020_06_17_156679	41	25	ligand	ligand	NN
10_1101-2020_06_17_156679	41	26	compounds	compound	NNS
10_1101-2020_06_17_156679	41	27	formulated	formulate	VBN
10_1101-2020_06_17_156679	41	28	in	in	IN
10_1101-2020_06_17_156679	41	29	NMR	NMR	NNP
10_1101-2020_06_17_156679	41	30	92	92	CD
10_1101-2020_06_17_156679	41	31	buffer	buffer	NN
10_1101-2020_06_17_156679	41	32	supplemented	supplement	VBN
10_1101-2020_06_17_156679	41	33	with	with	IN
10_1101-2020_06_17_156679	41	34	10	10	CD
10_1101-2020_06_17_156679	41	35	%	%	NN
10_1101-2020_06_17_156679	41	36	v	v	NN
10_1101-2020_06_17_156679	41	37	/	/	SYM
10_1101-2020_06_17_156679	41	38	v	v	NN
10_1101-2020_06_17_156679	41	39	D2O	d2o	NN
10_1101-2020_06_17_156679	41	40	and	and	CC
10_1101-2020_06_17_156679	41	41	deuterated	deuterated	JJ
10_1101-2020_06_17_156679	41	42	dimethyl	dimethyl	NN
10_1101-2020_06_17_156679	41	43	sulfoxide	sulfoxide	NN
10_1101-2020_06_17_156679	41	44	(	(	-LRB-
10_1101-2020_06_17_156679	41	45	D6-DMSO	d6-dmso	UH
10_1101-2020_06_17_156679	41	46	,	,	,
10_1101-2020_06_17_156679	41	47	99.96	99.96	CD
10_1101-2020_06_17_156679	41	48	%	%	NN
10_1101-2020_06_17_156679	41	49	D	d	NN
10_1101-2020_06_17_156679	41	50	,	,	,
10_1101-2020_06_17_156679	41	51	93	93	CD
10_1101-2020_06_17_156679	41	52	Sigma	Sigma	NNP
10_1101-2020_06_17_156679	41	53	Aldrich	Aldrich	NNP
10_1101-2020_06_17_156679	41	54	)	)	-RRB-
10_1101-2020_06_17_156679	41	55	to	to	IN
10_1101-2020_06_17_156679	41	56	5	5	CD
10_1101-2020_06_17_156679	41	57	%	%	NN
10_1101-2020_06_17_156679	41	58	v	v	NN
10_1101-2020_06_17_156679	41	59	/	/	SYM
10_1101-2020_06_17_156679	41	60	v	v	NN
10_1101-2020_06_17_156679	41	61	final	final	JJ
10_1101-2020_06_17_156679	41	62	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	41	63	concentration	concentration	NN
10_1101-2020_06_17_156679	41	64	.	.	.
10_1101-2020_06_17_156679	42	1	In	in	IN
10_1101-2020_06_17_156679	42	2	competition	competition	NN
10_1101-2020_06_17_156679	42	3	experiments	experiment	NNS
10_1101-2020_06_17_156679	42	4	,	,	,
10_1101-2020_06_17_156679	42	5	samples	sample	NNS
10_1101-2020_06_17_156679	42	6	94	94	CD
10_1101-2020_06_17_156679	42	7	comprised	comprise	VBD
10_1101-2020_06_17_156679	42	8	2	2	CD
10_1101-2020_06_17_156679	42	9	μM	μM	NNP
10_1101-2020_06_17_156679	42	10	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	42	11	,	,	,
10_1101-2020_06_17_156679	42	12	0.8	0.8	CD
10_1101-2020_06_17_156679	42	13	mM	mM	NNP
10_1101-2020_06_17_156679	42	14	of	of	IN
10_1101-2020_06_17_156679	42	15	ligand	ligand	NNP
10_1101-2020_06_17_156679	42	16	x0434	x0434	NNP
10_1101-2020_06_17_156679	42	17	and	and	CC
10_1101-2020_06_17_156679	42	18	variable	variable	JJ
10_1101-2020_06_17_156679	42	19	concentrations	concentration	NNS
10_1101-2020_06_17_156679	42	20	(	(	-LRB-
10_1101-2020_06_17_156679	42	21	0	0	CD
10_1101-2020_06_17_156679	42	22	–	–	:
10_1101-2020_06_17_156679	42	23	20	20	CD
10_1101-2020_06_17_156679	42	24	μM	μM	NNP
10_1101-2020_06_17_156679	42	25	)	)	-RRB-
10_1101-2020_06_17_156679	42	26	of	of	IN
10_1101-2020_06_17_156679	42	27	competing	compete	VBG
10_1101-2020_06_17_156679	42	28	95	95	CD
10_1101-2020_06_17_156679	42	29	compound	compound	NN
10_1101-2020_06_17_156679	42	30	in	in	IN
10_1101-2020_06_17_156679	42	31	NMR	NMR	NNP
10_1101-2020_06_17_156679	42	32	buffer	buffer	NNP
10_1101-2020_06_17_156679	42	33	supplemented	supplement	VBN
10_1101-2020_06_17_156679	42	34	with	with	IN
10_1101-2020_06_17_156679	42	35	D2O	d2o	NN
10_1101-2020_06_17_156679	42	36	and	and	CC
10_1101-2020_06_17_156679	42	37	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	42	38	as	as	IN
10_1101-2020_06_17_156679	42	39	above	above	RB
10_1101-2020_06_17_156679	42	40	.	.	.
10_1101-2020_06_17_156679	43	1	Sample	sample	NN
10_1101-2020_06_17_156679	43	2	volume	volume	NN
10_1101-2020_06_17_156679	43	3	was	be	VBD
10_1101-2020_06_17_156679	43	4	140	140	CD
10_1101-2020_06_17_156679	43	5	96	96	CD
10_1101-2020_06_17_156679	43	6	.CC	.cc	CD
10_1101-2020_06_17_156679	43	7	-	-	:
10_1101-2020_06_17_156679	43	8	BY	by	IN
10_1101-2020_06_17_156679	43	9	4.0	4.0	CD
10_1101-2020_06_17_156679	43	10	International	International	NNP
10_1101-2020_06_17_156679	43	11	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	43	12	under	under	IN
10_1101-2020_06_17_156679	43	13	a	a	DT
10_1101-2020_06_17_156679	43	14	(	(	-LRB-
10_1101-2020_06_17_156679	43	15	which	which	WDT
10_1101-2020_06_17_156679	43	16	was	be	VBD
10_1101-2020_06_17_156679	43	17	not	not	RB
10_1101-2020_06_17_156679	43	18	certified	certify	VBN
10_1101-2020_06_17_156679	43	19	by	by	IN
10_1101-2020_06_17_156679	43	20	peer	peer	NN
10_1101-2020_06_17_156679	43	21	review	review	NN
10_1101-2020_06_17_156679	43	22	)	)	-RRB-
10_1101-2020_06_17_156679	43	23	is	be	VBZ
10_1101-2020_06_17_156679	43	24	the	the	DT
10_1101-2020_06_17_156679	43	25	author	author	NN
10_1101-2020_06_17_156679	43	26	/	/	SYM
10_1101-2020_06_17_156679	43	27	funder	funder	NN
10_1101-2020_06_17_156679	43	28	,	,	,
10_1101-2020_06_17_156679	43	29	who	who	WP
10_1101-2020_06_17_156679	43	30	has	have	VBZ
10_1101-2020_06_17_156679	43	31	granted	grant	VBN
10_1101-2020_06_17_156679	43	32	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	43	33	a	a	DT
10_1101-2020_06_17_156679	43	34	license	license	NN
10_1101-2020_06_17_156679	43	35	to	to	TO
10_1101-2020_06_17_156679	43	36	display	display	VB
10_1101-2020_06_17_156679	43	37	the	the	DT
10_1101-2020_06_17_156679	43	38	preprint	preprint	NN
10_1101-2020_06_17_156679	43	39	in	in	IN
10_1101-2020_06_17_156679	43	40	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	43	41	.	.	.
10_1101-2020_06_17_156679	44	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	44	2	is	be	VBZ
10_1101-2020_06_17_156679	44	3	made	make	VBN
10_1101-2020_06_17_156679	44	4	The	the	DT
10_1101-2020_06_17_156679	44	5	copyright	copyright	NN
10_1101-2020_06_17_156679	44	6	holder	holder	NN
10_1101-2020_06_17_156679	44	7	for	for	IN
10_1101-2020_06_17_156679	44	8	this	this	DT
10_1101-2020_06_17_156679	44	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	44	10	version	version	NN
10_1101-2020_06_17_156679	44	11	posted	post	VBD
10_1101-2020_06_17_156679	44	12	January	January	NNP
10_1101-2020_06_17_156679	44	13	6	6	CD
10_1101-2020_06_17_156679	44	14	,	,	,
10_1101-2020_06_17_156679	44	15	2021	2021	CD
10_1101-2020_06_17_156679	44	16	.	.	.
10_1101-2020_06_17_156679	44	17	;	;	:
10_1101-2020_06_17_156679	44	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	44	19	:	:	:
10_1101-2020_06_17_156679	44	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	44	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	44	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	44	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	44	24	5	5	CD
10_1101-2020_06_17_156679	44	25	μL	μL	NNP
10_1101-2020_06_17_156679	44	26	and	and	CC
10_1101-2020_06_17_156679	44	27	samples	sample	NNS
10_1101-2020_06_17_156679	44	28	were	be	VBD
10_1101-2020_06_17_156679	44	29	loaded	load	VBN
10_1101-2020_06_17_156679	44	30	in	in	IN
10_1101-2020_06_17_156679	44	31	3	3	CD
10_1101-2020_06_17_156679	44	32	mm	mm	NN
10_1101-2020_06_17_156679	44	33	outer	outer	JJ
10_1101-2020_06_17_156679	44	34	diameter	diameter	NN
10_1101-2020_06_17_156679	44	35	SampleJet	SampleJet	NNP
10_1101-2020_06_17_156679	44	36	NMR	NMR	NNP
10_1101-2020_06_17_156679	44	37	tubes	tube	NNS
10_1101-2020_06_17_156679	44	38	(	(	-LRB-
10_1101-2020_06_17_156679	44	39	Bruker	Bruker	NNP
10_1101-2020_06_17_156679	44	40	)	)	-RRB-
10_1101-2020_06_17_156679	44	41	placed	place	VBD
10_1101-2020_06_17_156679	44	42	in	in	IN
10_1101-2020_06_17_156679	44	43	96	96	CD
10_1101-2020_06_17_156679	44	44	-	-	SYM
10_1101-2020_06_17_156679	44	45	97	97	CD
10_1101-2020_06_17_156679	44	46	tube	tube	NN
10_1101-2020_06_17_156679	44	47	racks	rack	NNS
10_1101-2020_06_17_156679	44	48	.	.	.
10_1101-2020_06_17_156679	45	1	NMR	NMR	NNP
10_1101-2020_06_17_156679	45	2	tubes	tube	NNS
10_1101-2020_06_17_156679	45	3	were	be	VBD
10_1101-2020_06_17_156679	45	4	sealed	seal	VBN
10_1101-2020_06_17_156679	45	5	with	with	IN
10_1101-2020_06_17_156679	45	6	POM	POM	NNP
10_1101-2020_06_17_156679	45	7	balls	ball	NNS
10_1101-2020_06_17_156679	45	8	.	.	.
10_1101-2020_06_17_156679	46	1	98	98	CD
10_1101-2020_06_17_156679	46	2	STD	STD	NNP
10_1101-2020_06_17_156679	46	3	-	-	HYPH
10_1101-2020_06_17_156679	46	4	NMR	NMR	NNP
10_1101-2020_06_17_156679	46	5	experiments	experiment	NNS
10_1101-2020_06_17_156679	46	6	were	be	VBD
10_1101-2020_06_17_156679	46	7	performed	perform	VBN
10_1101-2020_06_17_156679	46	8	at	at	IN
10_1101-2020_06_17_156679	46	9	10	10	CD
10_1101-2020_06_17_156679	46	10	oC	oC	NNP
10_1101-2020_06_17_156679	46	11	using	use	VBG
10_1101-2020_06_17_156679	46	12	a	a	DT
10_1101-2020_06_17_156679	46	13	pulse	pulse	NN
10_1101-2020_06_17_156679	46	14	sequence	sequence	NN
10_1101-2020_06_17_156679	46	15	described	describe	VBN
10_1101-2020_06_17_156679	46	16	previously	previously	RB
10_1101-2020_06_17_156679	46	17	(	(	-LRB-
10_1101-2020_06_17_156679	46	18	20	20	CD
10_1101-2020_06_17_156679	46	19	)	)	-RRB-
10_1101-2020_06_17_156679	46	20	99	99	CD
10_1101-2020_06_17_156679	46	21	and	and	CC
10_1101-2020_06_17_156679	46	22	an	an	DT
10_1101-2020_06_17_156679	46	23	excitation	excitation	NN
10_1101-2020_06_17_156679	46	24	sculpting	sculpt	VBG
10_1101-2020_06_17_156679	46	25	water	water	NN
10_1101-2020_06_17_156679	46	26	-	-	HYPH
10_1101-2020_06_17_156679	46	27	suppression	suppression	NN
10_1101-2020_06_17_156679	46	28	scheme	scheme	NN
10_1101-2020_06_17_156679	46	29	(	(	-LRB-
10_1101-2020_06_17_156679	46	30	24	24	CD
10_1101-2020_06_17_156679	46	31	)	)	-RRB-
10_1101-2020_06_17_156679	46	32	.	.	.
10_1101-2020_06_17_156679	47	1	Protein	protein	NN
10_1101-2020_06_17_156679	47	2	signals	signal	NNS
10_1101-2020_06_17_156679	47	3	were	be	VBD
10_1101-2020_06_17_156679	47	4	suppressed	suppress	VBN
10_1101-2020_06_17_156679	47	5	in	in	IN
10_1101-2020_06_17_156679	47	6	STD-100	std-100	JJ
10_1101-2020_06_17_156679	47	7	NMR	NMR	NNP
10_1101-2020_06_17_156679	47	8	by	by	IN
10_1101-2020_06_17_156679	47	9	the	the	DT
10_1101-2020_06_17_156679	47	10	application	application	NN
10_1101-2020_06_17_156679	47	11	of	of	IN
10_1101-2020_06_17_156679	47	12	a	a	DT
10_1101-2020_06_17_156679	47	13	30	30	CD
10_1101-2020_06_17_156679	47	14	msec	msec	NN
10_1101-2020_06_17_156679	47	15	spin	spin	NN
10_1101-2020_06_17_156679	47	16	-	-	HYPH
10_1101-2020_06_17_156679	47	17	lock	lock	NN
10_1101-2020_06_17_156679	47	18	pulse	pulse	NN
10_1101-2020_06_17_156679	47	19	.	.	.
10_1101-2020_06_17_156679	48	1	We	-PRON-	PRP
10_1101-2020_06_17_156679	48	2	collected	collect	VBD
10_1101-2020_06_17_156679	48	3	time	time	NN
10_1101-2020_06_17_156679	48	4	-	-	HYPH
10_1101-2020_06_17_156679	48	5	domain	domain	NN
10_1101-2020_06_17_156679	48	6	data	datum	NNS
10_1101-2020_06_17_156679	48	7	of	of	IN
10_1101-2020_06_17_156679	48	8	16,384	16,384	CD
10_1101-2020_06_17_156679	48	9	101	101	CD
10_1101-2020_06_17_156679	48	10	complex	complex	JJ
10_1101-2020_06_17_156679	48	11	points	point	NNS
10_1101-2020_06_17_156679	48	12	and	and	CC
10_1101-2020_06_17_156679	48	13	41.6	41.6	CD
10_1101-2020_06_17_156679	48	14	μsec	μsec	NNP
10_1101-2020_06_17_156679	48	15	dwell	dwell	NNP
10_1101-2020_06_17_156679	48	16	time	time	NNP
10_1101-2020_06_17_156679	48	17	(	(	-LRB-
10_1101-2020_06_17_156679	48	18	12.02	12.02	CD
10_1101-2020_06_17_156679	48	19	kHz	kHz	NNS
10_1101-2020_06_17_156679	48	20	sweepwidth	sweepwidth	NN
10_1101-2020_06_17_156679	48	21	)	)	-RRB-
10_1101-2020_06_17_156679	48	22	.	.	.
10_1101-2020_06_17_156679	49	1	Data	datum	NNS
10_1101-2020_06_17_156679	49	2	were	be	VBD
10_1101-2020_06_17_156679	49	3	collected	collect	VBN
10_1101-2020_06_17_156679	49	4	in	in	IN
10_1101-2020_06_17_156679	49	5	an	an	DT
10_1101-2020_06_17_156679	49	6	102	102	CD
10_1101-2020_06_17_156679	49	7	interleaved	interleaved	JJ
10_1101-2020_06_17_156679	49	8	pattern	pattern	NN
10_1101-2020_06_17_156679	49	9	,	,	,
10_1101-2020_06_17_156679	49	10	with	with	IN
10_1101-2020_06_17_156679	49	11	on-	on-	NN
10_1101-2020_06_17_156679	49	12	and	and	CC
10_1101-2020_06_17_156679	49	13	off	off	IN
10_1101-2020_06_17_156679	49	14	-	-	HYPH
10_1101-2020_06_17_156679	49	15	resonance	resonance	NN
10_1101-2020_06_17_156679	49	16	irradiation	irradiation	NN
10_1101-2020_06_17_156679	49	17	data	datum	NNS
10_1101-2020_06_17_156679	49	18	separated	separate	VBN
10_1101-2020_06_17_156679	49	19	into	into	IN
10_1101-2020_06_17_156679	49	20	16	16	CD
10_1101-2020_06_17_156679	49	21	blocks	block	NNS
10_1101-2020_06_17_156679	49	22	of	of	IN
10_1101-2020_06_17_156679	49	23	16	16	CD
10_1101-2020_06_17_156679	49	24	103	103	CD
10_1101-2020_06_17_156679	49	25	transients	transient	NNS
10_1101-2020_06_17_156679	49	26	each	each	DT
10_1101-2020_06_17_156679	49	27	(	(	-LRB-
10_1101-2020_06_17_156679	49	28	256	256	CD
10_1101-2020_06_17_156679	49	29	total	total	JJ
10_1101-2020_06_17_156679	49	30	transients	transient	NNS
10_1101-2020_06_17_156679	49	31	per	per	IN
10_1101-2020_06_17_156679	49	32	irradiation	irradiation	NN
10_1101-2020_06_17_156679	49	33	frequency	frequency	NN
10_1101-2020_06_17_156679	49	34	)	)	-RRB-
10_1101-2020_06_17_156679	49	35	.	.	.
10_1101-2020_06_17_156679	50	1	Transient	transient	JJ
10_1101-2020_06_17_156679	50	2	recycle	recycle	NN
10_1101-2020_06_17_156679	50	3	delay	delay	NN
10_1101-2020_06_17_156679	50	4	was	be	VBD
10_1101-2020_06_17_156679	50	5	4	4	CD
10_1101-2020_06_17_156679	50	6	sec	sec	NNP
10_1101-2020_06_17_156679	50	7	and	and	CC
10_1101-2020_06_17_156679	50	8	104	104	CD
10_1101-2020_06_17_156679	50	9	on-	on-	NNS
10_1101-2020_06_17_156679	50	10	or	or	CC
10_1101-2020_06_17_156679	50	11	off	off	IN
10_1101-2020_06_17_156679	50	12	-	-	HYPH
10_1101-2020_06_17_156679	50	13	resonance	resonance	NN
10_1101-2020_06_17_156679	50	14	irradiation	irradiation	NN
10_1101-2020_06_17_156679	50	15	was	be	VBD
10_1101-2020_06_17_156679	50	16	performed	perform	VBN
10_1101-2020_06_17_156679	50	17	using	use	VBG
10_1101-2020_06_17_156679	50	18	0.1	0.1	CD
10_1101-2020_06_17_156679	50	19	mW	mW	NNP
10_1101-2020_06_17_156679	50	20	of	of	IN
10_1101-2020_06_17_156679	50	21	power	power	NN
10_1101-2020_06_17_156679	50	22	for	for	IN
10_1101-2020_06_17_156679	50	23	3.5	3.5	CD
10_1101-2020_06_17_156679	50	24	sec	sec	NNP
10_1101-2020_06_17_156679	50	25	at	at	IN
10_1101-2020_06_17_156679	50	26	0.5	0.5	CD
10_1101-2020_06_17_156679	50	27	ppm	ppm	NN
10_1101-2020_06_17_156679	50	28	or	or	CC
10_1101-2020_06_17_156679	50	29	26	26	CD
10_1101-2020_06_17_156679	50	30	105	105	CD
10_1101-2020_06_17_156679	50	31	ppm	ppm	NN
10_1101-2020_06_17_156679	50	32	,	,	,
10_1101-2020_06_17_156679	50	33	respectively	respectively	RB
10_1101-2020_06_17_156679	50	34	,	,	,
10_1101-2020_06_17_156679	50	35	for	for	IN
10_1101-2020_06_17_156679	50	36	a	a	DT
10_1101-2020_06_17_156679	50	37	total	total	JJ
10_1101-2020_06_17_156679	50	38	experiment	experiment	NN
10_1101-2020_06_17_156679	50	39	time	time	NN
10_1101-2020_06_17_156679	50	40	of	of	IN
10_1101-2020_06_17_156679	50	41	approximately	approximately	RB
10_1101-2020_06_17_156679	50	42	50	50	CD
10_1101-2020_06_17_156679	50	43	minutes	minute	NNS
10_1101-2020_06_17_156679	50	44	.	.	.
10_1101-2020_06_17_156679	51	1	Reconstructed	reconstruct	VBN
10_1101-2020_06_17_156679	51	2	time-106	time-106	JJ
10_1101-2020_06_17_156679	51	3	domain	domain	NN
10_1101-2020_06_17_156679	51	4	data	datum	NNS
10_1101-2020_06_17_156679	51	5	from	from	IN
10_1101-2020_06_17_156679	51	6	the	the	DT
10_1101-2020_06_17_156679	51	7	difference	difference	NN
10_1101-2020_06_17_156679	51	8	of	of	IN
10_1101-2020_06_17_156679	51	9	on-	on-	NNP
10_1101-2020_06_17_156679	51	10	and	and	CC
10_1101-2020_06_17_156679	51	11	off	off	IN
10_1101-2020_06_17_156679	51	12	-	-	HYPH
10_1101-2020_06_17_156679	51	13	resonance	resonance	NN
10_1101-2020_06_17_156679	51	14	irradiation	irradiation	NN
10_1101-2020_06_17_156679	51	15	(	(	-LRB-
10_1101-2020_06_17_156679	51	16	STD	STD	NNP
10_1101-2020_06_17_156679	51	17	spectra	spectra	NNP
10_1101-2020_06_17_156679	51	18	)	)	-RRB-
10_1101-2020_06_17_156679	51	19	or	or	CC
10_1101-2020_06_17_156679	51	20	only	only	RB
10_1101-2020_06_17_156679	51	21	the	the	DT
10_1101-2020_06_17_156679	51	22	off-107	off-107	NNP
10_1101-2020_06_17_156679	51	23	resonance	resonance	NN
10_1101-2020_06_17_156679	51	24	irradiation	irradiation	NN
10_1101-2020_06_17_156679	51	25	(	(	-LRB-
10_1101-2020_06_17_156679	51	26	reference	reference	NN
10_1101-2020_06_17_156679	51	27	spectra	spectra	NNP
10_1101-2020_06_17_156679	51	28	)	)	-RRB-
10_1101-2020_06_17_156679	51	29	were	be	VBD
10_1101-2020_06_17_156679	51	30	processed	process	VBN
10_1101-2020_06_17_156679	51	31	by	by	IN
10_1101-2020_06_17_156679	51	32	applying	apply	VBG
10_1101-2020_06_17_156679	51	33	a	a	DT
10_1101-2020_06_17_156679	51	34	2	2	CD
10_1101-2020_06_17_156679	51	35	Hz	Hz	NNP
10_1101-2020_06_17_156679	51	36	exponential	exponential	JJ
10_1101-2020_06_17_156679	51	37	line	line	NN
10_1101-2020_06_17_156679	51	38	108	108	CD
10_1101-2020_06_17_156679	51	39	broadening	broadening	NN
10_1101-2020_06_17_156679	51	40	function	function	NN
10_1101-2020_06_17_156679	51	41	and	and	CC
10_1101-2020_06_17_156679	51	42	2-fold	2-fold	CD
10_1101-2020_06_17_156679	51	43	zero	zero	CD
10_1101-2020_06_17_156679	51	44	-	-	HYPH
10_1101-2020_06_17_156679	51	45	filling	filling	NN
10_1101-2020_06_17_156679	51	46	prior	prior	RB
10_1101-2020_06_17_156679	51	47	to	to	IN
10_1101-2020_06_17_156679	51	48	Fourier	Fourier	NNP
10_1101-2020_06_17_156679	51	49	transformation	transformation	NN
10_1101-2020_06_17_156679	51	50	.	.	.
10_1101-2020_06_17_156679	52	1	Phasing	phase	VBG
10_1101-2020_06_17_156679	52	2	parameters	parameter	NNS
10_1101-2020_06_17_156679	52	3	were	be	VBD
10_1101-2020_06_17_156679	52	4	109	109	CD
10_1101-2020_06_17_156679	52	5	derived	derive	VBN
10_1101-2020_06_17_156679	52	6	for	for	IN
10_1101-2020_06_17_156679	52	7	each	each	DT
10_1101-2020_06_17_156679	52	8	sample	sample	NN
10_1101-2020_06_17_156679	52	9	from	from	IN
10_1101-2020_06_17_156679	52	10	the	the	DT
10_1101-2020_06_17_156679	52	11	reference	reference	NN
10_1101-2020_06_17_156679	52	12	spectra	spectra	NNP
10_1101-2020_06_17_156679	52	13	and	and	CC
10_1101-2020_06_17_156679	52	14	copied	copy	VBD
10_1101-2020_06_17_156679	52	15	to	to	IN
10_1101-2020_06_17_156679	52	16	the	the	DT
10_1101-2020_06_17_156679	52	17	STD	STD	NNP
10_1101-2020_06_17_156679	52	18	spectra	spectra	NN
10_1101-2020_06_17_156679	52	19	.	.	.
10_1101-2020_06_17_156679	53	1	1H	1H	NNP
10_1101-2020_06_17_156679	53	2	peak	peak	NN
10_1101-2020_06_17_156679	53	3	110	110	CD
10_1101-2020_06_17_156679	53	4	intensities	intensity	NNS
10_1101-2020_06_17_156679	53	5	were	be	VBD
10_1101-2020_06_17_156679	53	6	integrated	integrate	VBN
10_1101-2020_06_17_156679	53	7	in	in	IN
10_1101-2020_06_17_156679	53	8	TopSpin	TopSpin	NNP
10_1101-2020_06_17_156679	53	9	using	use	VBG
10_1101-2020_06_17_156679	53	10	a	a	DT
10_1101-2020_06_17_156679	53	11	local	local	JJ
10_1101-2020_06_17_156679	53	12	-	-	HYPH
10_1101-2020_06_17_156679	53	13	baseline	baseline	NN
10_1101-2020_06_17_156679	53	14	adjustment	adjustment	NN
10_1101-2020_06_17_156679	53	15	function	function	NN
10_1101-2020_06_17_156679	53	16	.	.	.
10_1101-2020_06_17_156679	54	1	Data	datum	NNS
10_1101-2020_06_17_156679	54	2	fitting	fitting	JJ
10_1101-2020_06_17_156679	54	3	to	to	IN
10_1101-2020_06_17_156679	54	4	111	111	CD
10_1101-2020_06_17_156679	54	5	extract	extract	NN
10_1101-2020_06_17_156679	54	6	Kd	Kd	NNP
10_1101-2020_06_17_156679	54	7	values	value	NNS
10_1101-2020_06_17_156679	54	8	were	be	VBD
10_1101-2020_06_17_156679	54	9	performed	perform	VBN
10_1101-2020_06_17_156679	54	10	in	in	IN
10_1101-2020_06_17_156679	54	11	OriginPro	OriginPro	NNP
10_1101-2020_06_17_156679	54	12	(	(	-LRB-
10_1101-2020_06_17_156679	54	13	OriginLab	OriginLab	NNP
10_1101-2020_06_17_156679	54	14	)	)	-RRB-
10_1101-2020_06_17_156679	54	15	.	.	.
10_1101-2020_06_17_156679	55	1	The	the	DT
10_1101-2020_06_17_156679	55	2	folded	fold	VBN
10_1101-2020_06_17_156679	55	3	state	state	NN
10_1101-2020_06_17_156679	55	4	of	of	IN
10_1101-2020_06_17_156679	55	5	M	m	NN
10_1101-2020_06_17_156679	55	6	pro	pro	JJ
10_1101-2020_06_17_156679	55	7	in	in	IN
10_1101-2020_06_17_156679	55	8	the	the	DT
10_1101-2020_06_17_156679	55	9	presence	presence	NN
10_1101-2020_06_17_156679	55	10	112	112	CD
10_1101-2020_06_17_156679	55	11	of	of	IN
10_1101-2020_06_17_156679	55	12	each	each	DT
10_1101-2020_06_17_156679	55	13	ligand	ligand	NN
10_1101-2020_06_17_156679	55	14	was	be	VBD
10_1101-2020_06_17_156679	55	15	verified	verify	VBN
10_1101-2020_06_17_156679	55	16	by	by	IN
10_1101-2020_06_17_156679	55	17	collecting	collect	VBG
10_1101-2020_06_17_156679	55	18	1H	1h	JJ
10_1101-2020_06_17_156679	55	19	NMR	NMR	NNP
10_1101-2020_06_17_156679	55	20	spectra	spectra	NNP
10_1101-2020_06_17_156679	55	21	similar	similar	JJ
10_1101-2020_06_17_156679	55	22	to	to	IN
10_1101-2020_06_17_156679	55	23	Fig	Fig	NNP
10_1101-2020_06_17_156679	55	24	.	.	.
10_1101-2020_06_17_156679	56	1	1A	1a	CD
10_1101-2020_06_17_156679	56	2	from	from	IN
10_1101-2020_06_17_156679	56	3	all	all	DT
10_1101-2020_06_17_156679	56	4	samples	sample	NNS
10_1101-2020_06_17_156679	56	5	ahead	ahead	RB
10_1101-2020_06_17_156679	56	6	of	of	IN
10_1101-2020_06_17_156679	56	7	113	113	CD
10_1101-2020_06_17_156679	56	8	STD	STD	NNP
10_1101-2020_06_17_156679	56	9	-	-	HYPH
10_1101-2020_06_17_156679	56	10	NMR	NMR	NNP
10_1101-2020_06_17_156679	56	11	experiments	experiment	NNS
10_1101-2020_06_17_156679	56	12	.	.	.
10_1101-2020_06_17_156679	57	1	114	114	CD
10_1101-2020_06_17_156679	57	2	115	115	CD
10_1101-2020_06_17_156679	57	3	Ligand	Ligand	NNP
10_1101-2020_06_17_156679	57	4	handling	handle	VBG
10_1101-2020_06_17_156679	57	5	116	116	CD
10_1101-2020_06_17_156679	57	6	Compounds	compound	NNS
10_1101-2020_06_17_156679	57	7	for	for	IN
10_1101-2020_06_17_156679	57	8	the	the	DT
10_1101-2020_06_17_156679	57	9	initial	initial	JJ
10_1101-2020_06_17_156679	57	10	STD	STD	NNP
10_1101-2020_06_17_156679	57	11	-	-	HYPH
10_1101-2020_06_17_156679	57	12	NMR	NMR	NNP
10_1101-2020_06_17_156679	57	13	assessment	assessment	NN
10_1101-2020_06_17_156679	57	14	of	of	IN
10_1101-2020_06_17_156679	57	15	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	57	16	fragment	fragment	NN
10_1101-2020_06_17_156679	57	17	binding	bind	VBG
10_1101-2020_06_17_156679	57	18	to	to	IN
10_1101-2020_06_17_156679	57	19	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	57	20	were	be	VBD
10_1101-2020_06_17_156679	57	21	117	117	CD
10_1101-2020_06_17_156679	57	22	provided	provide	VBN
10_1101-2020_06_17_156679	57	23	by	by	IN
10_1101-2020_06_17_156679	57	24	the	the	DT
10_1101-2020_06_17_156679	57	25	XChem	XChem	NNP
10_1101-2020_06_17_156679	57	26	group	group	NN
10_1101-2020_06_17_156679	57	27	at	at	IN
10_1101-2020_06_17_156679	57	28	Diamond	Diamond	NNP
10_1101-2020_06_17_156679	57	29	Light	Light	NNP
10_1101-2020_06_17_156679	57	30	Source	Source	NNP
10_1101-2020_06_17_156679	57	31	in	in	IN
10_1101-2020_06_17_156679	57	32	the	the	DT
10_1101-2020_06_17_156679	57	33	form	form	NN
10_1101-2020_06_17_156679	57	34	of	of	IN
10_1101-2020_06_17_156679	57	35	a	a	DT
10_1101-2020_06_17_156679	57	36	384-well	384-well	CD
10_1101-2020_06_17_156679	57	37	plated	plate	VBN
10_1101-2020_06_17_156679	57	38	library	library	NN
10_1101-2020_06_17_156679	57	39	(	(	-LRB-
10_1101-2020_06_17_156679	57	40	DSI-118	dsi-118	PRP
10_1101-2020_06_17_156679	57	41	poised	poise	VBN
10_1101-2020_06_17_156679	57	42	,	,	,
10_1101-2020_06_17_156679	57	43	Enamine	Enamine	NNP
10_1101-2020_06_17_156679	57	44	)	)	-RRB-
10_1101-2020_06_17_156679	57	45	,	,	,
10_1101-2020_06_17_156679	57	46	with	with	IN
10_1101-2020_06_17_156679	57	47	compounds	compound	NNS
10_1101-2020_06_17_156679	57	48	dissolved	dissolve	VBN
10_1101-2020_06_17_156679	57	49	in	in	IN
10_1101-2020_06_17_156679	57	50	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	57	51	at	at	IN
10_1101-2020_06_17_156679	57	52	500	500	CD
10_1101-2020_06_17_156679	57	53	mM	mM	NNP
10_1101-2020_06_17_156679	57	54	nominal	nominal	JJ
10_1101-2020_06_17_156679	57	55	concentration	concentration	NN
10_1101-2020_06_17_156679	57	56	.	.	.
10_1101-2020_06_17_156679	58	1	1	1	LS
10_1101-2020_06_17_156679	58	2	μL	μL	NNP
10_1101-2020_06_17_156679	58	3	of	of	IN
10_1101-2020_06_17_156679	58	4	119	119	CD
10_1101-2020_06_17_156679	58	5	dissolved	dissolve	VBN
10_1101-2020_06_17_156679	58	6	compounds	compound	NNS
10_1101-2020_06_17_156679	58	7	was	be	VBD
10_1101-2020_06_17_156679	58	8	aspirated	aspirate	VBN
10_1101-2020_06_17_156679	58	9	from	from	IN
10_1101-2020_06_17_156679	58	10	this	this	DT
10_1101-2020_06_17_156679	58	11	library	library	NN
10_1101-2020_06_17_156679	58	12	and	and	CC
10_1101-2020_06_17_156679	58	13	immediately	immediately	RB
10_1101-2020_06_17_156679	58	14	mixed	mix	VBN
10_1101-2020_06_17_156679	58	15	with	with	IN
10_1101-2020_06_17_156679	58	16	9	9	CD
10_1101-2020_06_17_156679	58	17	μL	μl	NN
10_1101-2020_06_17_156679	58	18	of	of	IN
10_1101-2020_06_17_156679	58	19	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	58	20	120	120	CD
10_1101-2020_06_17_156679	58	21	for	for	IN
10_1101-2020_06_17_156679	58	22	a	a	DT
10_1101-2020_06_17_156679	58	23	final	final	JJ
10_1101-2020_06_17_156679	58	24	fragment	fragment	NN
10_1101-2020_06_17_156679	58	25	concentration	concentration	NN
10_1101-2020_06_17_156679	58	26	of	of	IN
10_1101-2020_06_17_156679	58	27	50	50	CD
10_1101-2020_06_17_156679	58	28	mM	mM	NNP
10_1101-2020_06_17_156679	58	29	,	,	,
10_1101-2020_06_17_156679	58	30	from	from	IN
10_1101-2020_06_17_156679	58	31	which	which	WDT
10_1101-2020_06_17_156679	58	32	NMR	NMR	NNP
10_1101-2020_06_17_156679	58	33	samples	sample	NNS
10_1101-2020_06_17_156679	58	34	were	be	VBD
10_1101-2020_06_17_156679	58	35	formulated	formulate	VBN
10_1101-2020_06_17_156679	58	36	.	.	.
10_1101-2020_06_17_156679	59	1	For	for	IN
10_1101-2020_06_17_156679	59	2	121	121	CD
10_1101-2020_06_17_156679	59	3	titrations	titration	NNS
10_1101-2020_06_17_156679	59	4	of	of	IN
10_1101-2020_06_17_156679	59	5	the	the	DT
10_1101-2020_06_17_156679	59	6	same	same	JJ
10_1101-2020_06_17_156679	59	7	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	59	8	fragments	fragment	NNS
10_1101-2020_06_17_156679	59	9	compounds	compound	NNS
10_1101-2020_06_17_156679	59	10	were	be	VBD
10_1101-2020_06_17_156679	59	11	procured	procure	VBN
10_1101-2020_06_17_156679	59	12	directly	directly	RB
10_1101-2020_06_17_156679	59	13	from	from	IN
10_1101-2020_06_17_156679	59	14	Enamine	Enamine	NNP
10_1101-2020_06_17_156679	59	15	122	122	CD
10_1101-2020_06_17_156679	59	16	in	in	IN
10_1101-2020_06_17_156679	59	17	the	the	DT
10_1101-2020_06_17_156679	59	18	form	form	NN
10_1101-2020_06_17_156679	59	19	of	of	IN
10_1101-2020_06_17_156679	59	20	lyophilized	lyophilized	JJ
10_1101-2020_06_17_156679	59	21	powder	powder	NN
10_1101-2020_06_17_156679	59	22	,	,	,
10_1101-2020_06_17_156679	59	23	which	which	WDT
10_1101-2020_06_17_156679	59	24	was	be	VBD
10_1101-2020_06_17_156679	59	25	dissolved	dissolve	VBN
10_1101-2020_06_17_156679	59	26	in	in	IN
10_1101-2020_06_17_156679	59	27	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	59	28	to	to	TO
10_1101-2020_06_17_156679	59	29	derive	derive	VB
10_1101-2020_06_17_156679	59	30	compound	compound	NN
10_1101-2020_06_17_156679	59	31	stocks	stock	NNS
10_1101-2020_06_17_156679	59	32	at	at	IN
10_1101-2020_06_17_156679	59	33	10	10	CD
10_1101-2020_06_17_156679	59	34	123	123	CD
10_1101-2020_06_17_156679	59	35	mM	mm	NN
10_1101-2020_06_17_156679	59	36	and	and	CC
10_1101-2020_06_17_156679	59	37	100	100	CD
10_1101-2020_06_17_156679	59	38	mM	mm	NN
10_1101-2020_06_17_156679	59	39	concentrations	concentration	NNS
10_1101-2020_06_17_156679	59	40	for	for	IN
10_1101-2020_06_17_156679	59	41	NMR	NMR	NNP
10_1101-2020_06_17_156679	59	42	sample	sample	NN
10_1101-2020_06_17_156679	59	43	formulation	formulation	NN
10_1101-2020_06_17_156679	59	44	.	.	.
10_1101-2020_06_17_156679	60	1	124	124	CD
10_1101-2020_06_17_156679	60	2	STD	STD	NNP
10_1101-2020_06_17_156679	60	3	-	-	HYPH
10_1101-2020_06_17_156679	60	4	NMR	NMR	NNP
10_1101-2020_06_17_156679	60	5	assays	assay	NNS
10_1101-2020_06_17_156679	60	6	of	of	IN
10_1101-2020_06_17_156679	60	7	bespoke	bespoke	NN
10_1101-2020_06_17_156679	60	8	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	60	9	ligands	ligand	VBZ
10_1101-2020_06_17_156679	60	10	used	use	VBN
10_1101-2020_06_17_156679	60	11	compounds	compound	NNS
10_1101-2020_06_17_156679	60	12	commercially	commercially	RB
10_1101-2020_06_17_156679	60	13	synthesised	synthesise	VBN
10_1101-2020_06_17_156679	60	14	for	for	IN
10_1101-2020_06_17_156679	60	15	COVID	COVID	NNP
10_1101-2020_06_17_156679	60	16	125	125	CD
10_1101-2020_06_17_156679	60	17	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	60	18	.	.	.
10_1101-2020_06_17_156679	61	1	These	these	DT
10_1101-2020_06_17_156679	61	2	ligands	ligand	NNS
10_1101-2020_06_17_156679	61	3	were	be	VBD
10_1101-2020_06_17_156679	61	4	provided	provide	VBN
10_1101-2020_06_17_156679	61	5	to	to	IN
10_1101-2020_06_17_156679	61	6	us	-PRON-	PRP
10_1101-2020_06_17_156679	61	7	by	by	IN
10_1101-2020_06_17_156679	61	8	the	the	DT
10_1101-2020_06_17_156679	61	9	XChem	XChem	NNP
10_1101-2020_06_17_156679	61	10	group	group	NN
10_1101-2020_06_17_156679	61	11	in	in	IN
10_1101-2020_06_17_156679	61	12	96-well	96-well	CD
10_1101-2020_06_17_156679	61	13	plates	plate	NNS
10_1101-2020_06_17_156679	61	14	,	,	,
10_1101-2020_06_17_156679	61	15	containing	contain	VBG
10_1101-2020_06_17_156679	61	16	0.7	0.7	CD
10_1101-2020_06_17_156679	61	17	126	126	CD
10_1101-2020_06_17_156679	61	18	μL	μL	NNS
10_1101-2020_06_17_156679	61	19	of	of	IN
10_1101-2020_06_17_156679	61	20	20	20	CD
10_1101-2020_06_17_156679	61	21	mM	mM	NNP
10_1101-2020_06_17_156679	61	22	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	61	23	-	-	HYPH
10_1101-2020_06_17_156679	61	24	disolved	disolve	VBN
10_1101-2020_06_17_156679	61	25	compound	compound	NN
10_1101-2020_06_17_156679	61	26	per	per	IN
10_1101-2020_06_17_156679	61	27	well	well	RB
10_1101-2020_06_17_156679	61	28	.	.	.
10_1101-2020_06_17_156679	62	1	Plates	plate	NNS
10_1101-2020_06_17_156679	62	2	were	be	VBD
10_1101-2020_06_17_156679	62	3	created	create	VBN
10_1101-2020_06_17_156679	62	4	using	use	VBG
10_1101-2020_06_17_156679	62	5	an	an	DT
10_1101-2020_06_17_156679	62	6	Echo	Echo	NNP
10_1101-2020_06_17_156679	62	7	liquid	liquid	NN
10_1101-2020_06_17_156679	62	8	127	127	CD
10_1101-2020_06_17_156679	62	9	handling	handling	NN
10_1101-2020_06_17_156679	62	10	robot	robot	NN
10_1101-2020_06_17_156679	62	11	(	(	-LRB-
10_1101-2020_06_17_156679	62	12	Labcyte	Labcyte	NNP
10_1101-2020_06_17_156679	62	13	)	)	-RRB-
10_1101-2020_06_17_156679	62	14	and	and	CC
10_1101-2020_06_17_156679	62	15	immediately	immediately	RB
10_1101-2020_06_17_156679	62	16	sealed	seal	VBN
10_1101-2020_06_17_156679	62	17	and	and	CC
10_1101-2020_06_17_156679	62	18	frozen	freeze	VBN
10_1101-2020_06_17_156679	62	19	at	at	IN
10_1101-2020_06_17_156679	62	20	-20	-20	NNP
10_1101-2020_06_17_156679	62	21	oC.	oC.	NNP
10_1101-2020_06_17_156679	63	1	For	for	IN
10_1101-2020_06_17_156679	63	2	use	use	NN
10_1101-2020_06_17_156679	63	3	,	,	,
10_1101-2020_06_17_156679	63	4	ligand	ligand	NN
10_1101-2020_06_17_156679	63	5	plates	plate	NNS
10_1101-2020_06_17_156679	63	6	were	be	VBD
10_1101-2020_06_17_156679	63	7	128	128	CD
10_1101-2020_06_17_156679	63	8	.CC	.CC	NFP
10_1101-2020_06_17_156679	63	9	-	-	:
10_1101-2020_06_17_156679	63	10	BY	by	IN
10_1101-2020_06_17_156679	63	11	4.0	4.0	CD
10_1101-2020_06_17_156679	63	12	International	International	NNP
10_1101-2020_06_17_156679	63	13	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	63	14	under	under	IN
10_1101-2020_06_17_156679	63	15	a	a	DT
10_1101-2020_06_17_156679	63	16	(	(	-LRB-
10_1101-2020_06_17_156679	63	17	which	which	WDT
10_1101-2020_06_17_156679	63	18	was	be	VBD
10_1101-2020_06_17_156679	63	19	not	not	RB
10_1101-2020_06_17_156679	63	20	certified	certify	VBN
10_1101-2020_06_17_156679	63	21	by	by	IN
10_1101-2020_06_17_156679	63	22	peer	peer	NN
10_1101-2020_06_17_156679	63	23	review	review	NN
10_1101-2020_06_17_156679	63	24	)	)	-RRB-
10_1101-2020_06_17_156679	63	25	is	be	VBZ
10_1101-2020_06_17_156679	63	26	the	the	DT
10_1101-2020_06_17_156679	63	27	author	author	NN
10_1101-2020_06_17_156679	63	28	/	/	SYM
10_1101-2020_06_17_156679	63	29	funder	funder	NN
10_1101-2020_06_17_156679	63	30	,	,	,
10_1101-2020_06_17_156679	63	31	who	who	WP
10_1101-2020_06_17_156679	63	32	has	have	VBZ
10_1101-2020_06_17_156679	63	33	granted	grant	VBN
10_1101-2020_06_17_156679	63	34	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	63	35	a	a	DT
10_1101-2020_06_17_156679	63	36	license	license	NN
10_1101-2020_06_17_156679	63	37	to	to	TO
10_1101-2020_06_17_156679	63	38	display	display	VB
10_1101-2020_06_17_156679	63	39	the	the	DT
10_1101-2020_06_17_156679	63	40	preprint	preprint	NN
10_1101-2020_06_17_156679	63	41	in	in	IN
10_1101-2020_06_17_156679	63	42	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	63	43	.	.	.
10_1101-2020_06_17_156679	64	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	64	2	is	be	VBZ
10_1101-2020_06_17_156679	64	3	made	make	VBN
10_1101-2020_06_17_156679	64	4	The	the	DT
10_1101-2020_06_17_156679	64	5	copyright	copyright	NN
10_1101-2020_06_17_156679	64	6	holder	holder	NN
10_1101-2020_06_17_156679	64	7	for	for	IN
10_1101-2020_06_17_156679	64	8	this	this	DT
10_1101-2020_06_17_156679	64	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	64	10	version	version	NN
10_1101-2020_06_17_156679	64	11	posted	post	VBD
10_1101-2020_06_17_156679	64	12	January	January	NNP
10_1101-2020_06_17_156679	64	13	6	6	CD
10_1101-2020_06_17_156679	64	14	,	,	,
10_1101-2020_06_17_156679	64	15	2021	2021	CD
10_1101-2020_06_17_156679	64	16	.	.	.
10_1101-2020_06_17_156679	64	17	;	;	:
10_1101-2020_06_17_156679	64	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	64	19	:	:	:
10_1101-2020_06_17_156679	64	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	64	21	preprint	preprint	NN
10_1101-2020_06_17_156679	64	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	64	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	64	24	6	6	CD
10_1101-2020_06_17_156679	64	25	thoroughly	thoroughly	RB
10_1101-2020_06_17_156679	64	26	defrosted	defrost	VBN
10_1101-2020_06_17_156679	64	27	at	at	IN
10_1101-2020_06_17_156679	64	28	room	room	NN
10_1101-2020_06_17_156679	64	29	temperature	temperature	NN
10_1101-2020_06_17_156679	64	30	and	and	CC
10_1101-2020_06_17_156679	64	31	spun	spin	VBD
10_1101-2020_06_17_156679	64	32	at	at	IN
10_1101-2020_06_17_156679	64	33	3,500	3,500	CD
10_1101-2020_06_17_156679	64	34	g	g	NN
10_1101-2020_06_17_156679	64	35	for	for	IN
10_1101-2020_06_17_156679	64	36	5	5	CD
10_1101-2020_06_17_156679	64	37	minutes	minute	NNS
10_1101-2020_06_17_156679	64	38	.	.	.
10_1101-2020_06_17_156679	65	1	In	in	IN
10_1101-2020_06_17_156679	65	2	single-129	single-129	NNP
10_1101-2020_06_17_156679	65	3	concentration	concentration	NN
10_1101-2020_06_17_156679	65	4	STD	STD	NNP
10_1101-2020_06_17_156679	65	5	-	-	HYPH
10_1101-2020_06_17_156679	65	6	NMR	NMR	NNP
10_1101-2020_06_17_156679	65	7	experiments	experiment	NNS
10_1101-2020_06_17_156679	65	8	,	,	,
10_1101-2020_06_17_156679	65	9	140	140	CD
10_1101-2020_06_17_156679	65	10	μL	μL	NNS
10_1101-2020_06_17_156679	65	11	of	of	IN
10_1101-2020_06_17_156679	65	12	a	a	DT
10_1101-2020_06_17_156679	65	13	pre	pre	JJ
10_1101-2020_06_17_156679	65	14	-	-	JJ
10_1101-2020_06_17_156679	65	15	formulated	formulated	JJ
10_1101-2020_06_17_156679	65	16	mixture	mixture	NN
10_1101-2020_06_17_156679	65	17	of	of	IN
10_1101-2020_06_17_156679	65	18	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	65	19	and	and	CC
10_1101-2020_06_17_156679	65	20	NMR	NMR	NNP
10_1101-2020_06_17_156679	65	21	buffer	buffer	NNP
10_1101-2020_06_17_156679	65	22	130	130	CD
10_1101-2020_06_17_156679	65	23	with	with	IN
10_1101-2020_06_17_156679	65	24	D2O	d2o	NN
10_1101-2020_06_17_156679	65	25	and	and	CC
10_1101-2020_06_17_156679	65	26	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	65	27	were	be	VBD
10_1101-2020_06_17_156679	65	28	added	add	VBN
10_1101-2020_06_17_156679	65	29	to	to	IN
10_1101-2020_06_17_156679	65	30	each	each	DT
10_1101-2020_06_17_156679	65	31	well	well	NN
10_1101-2020_06_17_156679	65	32	to	to	TO
10_1101-2020_06_17_156679	65	33	create	create	VB
10_1101-2020_06_17_156679	65	34	the	the	DT
10_1101-2020_06_17_156679	65	35	final	final	JJ
10_1101-2020_06_17_156679	65	36	NMR	NMR	NNP
10_1101-2020_06_17_156679	65	37	sample	sample	NN
10_1101-2020_06_17_156679	65	38	.	.	.
10_1101-2020_06_17_156679	66	1	For	for	IN
10_1101-2020_06_17_156679	66	2	STD	STD	NNP
10_1101-2020_06_17_156679	66	3	-	-	HYPH
10_1101-2020_06_17_156679	66	4	NMR	NMR	NNP
10_1101-2020_06_17_156679	66	5	131	131	CD
10_1101-2020_06_17_156679	66	6	competition	competition	NN
10_1101-2020_06_17_156679	66	7	experiments	experiment	NNS
10_1101-2020_06_17_156679	66	8	,	,	,
10_1101-2020_06_17_156679	66	9	0.5	0.5	CD
10_1101-2020_06_17_156679	66	10	μL	μl	NN
10_1101-2020_06_17_156679	66	11	of	of	IN
10_1101-2020_06_17_156679	66	12	ligands	ligand	NNS
10_1101-2020_06_17_156679	66	13	were	be	VBD
10_1101-2020_06_17_156679	66	14	aspirated	aspirate	VBN
10_1101-2020_06_17_156679	66	15	from	from	IN
10_1101-2020_06_17_156679	66	16	the	the	DT
10_1101-2020_06_17_156679	66	17	plates	plate	NNS
10_1101-2020_06_17_156679	66	18	and	and	CC
10_1101-2020_06_17_156679	66	19	immediately	immediately	RB
10_1101-2020_06_17_156679	66	20	mixed	mix	VBD
10_1101-2020_06_17_156679	66	21	132	132	CD
10_1101-2020_06_17_156679	66	22	with	with	IN
10_1101-2020_06_17_156679	66	23	19.5	19.5	CD
10_1101-2020_06_17_156679	66	24	μL	μL	NNS
10_1101-2020_06_17_156679	66	25	of	of	IN
10_1101-2020_06_17_156679	66	26	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	66	27	for	for	IN
10_1101-2020_06_17_156679	66	28	final	final	JJ
10_1101-2020_06_17_156679	66	29	ligand	ligand	NN
10_1101-2020_06_17_156679	66	30	concentration	concentration	NN
10_1101-2020_06_17_156679	66	31	of	of	IN
10_1101-2020_06_17_156679	66	32	0.5	0.5	CD
10_1101-2020_06_17_156679	66	33	mM	mm	NN
10_1101-2020_06_17_156679	66	34	from	from	IN
10_1101-2020_06_17_156679	66	35	which	which	WDT
10_1101-2020_06_17_156679	66	36	NMR	NMR	NNP
10_1101-2020_06_17_156679	66	37	samples	sample	NNS
10_1101-2020_06_17_156679	66	38	were	be	VBD
10_1101-2020_06_17_156679	66	39	133	133	CD
10_1101-2020_06_17_156679	66	40	formulated	formulate	VBN
10_1101-2020_06_17_156679	66	41	.	.	.
10_1101-2020_06_17_156679	67	1	134	134	CD
10_1101-2020_06_17_156679	67	2	135	135	CD
10_1101-2020_06_17_156679	67	3	Molecular	Molecular	NNP
10_1101-2020_06_17_156679	67	4	dynamics	dynamic	NNS
10_1101-2020_06_17_156679	67	5	(	(	-LRB-
10_1101-2020_06_17_156679	67	6	MD	MD	NNP
10_1101-2020_06_17_156679	67	7	)	)	-RRB-
10_1101-2020_06_17_156679	67	8	simulations	simulation	VBZ
10_1101-2020_06_17_156679	67	9	136	136	CD
10_1101-2020_06_17_156679	67	10	The	the	DT
10_1101-2020_06_17_156679	67	11	monomeric	monomeric	JJ
10_1101-2020_06_17_156679	67	12	complexes	complex	NNS
10_1101-2020_06_17_156679	67	13	of	of	IN
10_1101-2020_06_17_156679	67	14	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	67	15	bound	bind	VBN
10_1101-2020_06_17_156679	67	16	to	to	IN
10_1101-2020_06_17_156679	67	17	chemical	chemical	NN
10_1101-2020_06_17_156679	67	18	fragments	fragment	NNS
10_1101-2020_06_17_156679	67	19	were	be	VBD
10_1101-2020_06_17_156679	67	20	obtained	obtain	VBN
10_1101-2020_06_17_156679	67	21	from	from	IN
10_1101-2020_06_17_156679	67	22	the	the	DT
10_1101-2020_06_17_156679	67	23	RCSB	RCSB	NNP
10_1101-2020_06_17_156679	67	24	137	137	CD
10_1101-2020_06_17_156679	67	25	Protein	Protein	NNP
10_1101-2020_06_17_156679	67	26	Data	Data	NNPS
10_1101-2020_06_17_156679	67	27	Bank	Bank	NNP
10_1101-2020_06_17_156679	67	28	entries	entrie	VBZ
10_1101-2020_06_17_156679	67	29	5R81	5r81	CD
10_1101-2020_06_17_156679	67	30	(	(	-LRB-
10_1101-2020_06_17_156679	67	31	ligand	ligand	NNP
10_1101-2020_06_17_156679	67	32	x0195	x0195	NNP
10_1101-2020_06_17_156679	67	33	)	)	-RRB-
10_1101-2020_06_17_156679	67	34	,	,	,
10_1101-2020_06_17_156679	67	35	5REB	5REB	NNP
10_1101-2020_06_17_156679	67	36	(	(	-LRB-
10_1101-2020_06_17_156679	67	37	x0387	x0387	NNP
10_1101-2020_06_17_156679	67	38	)	)	-RRB-
10_1101-2020_06_17_156679	67	39	,	,	,
10_1101-2020_06_17_156679	67	40	5RGI	5RGI	NNP
10_1101-2020_06_17_156679	67	41	(	(	-LRB-
10_1101-2020_06_17_156679	67	42	x0397	x0397	NNP
10_1101-2020_06_17_156679	67	43	)	)	-RRB-
10_1101-2020_06_17_156679	67	44	,	,	,
10_1101-2020_06_17_156679	67	45	5RGK	5RGK	NNP
10_1101-2020_06_17_156679	67	46	(	(	-LRB-
10_1101-2020_06_17_156679	67	47	x0426	x0426	NNP
10_1101-2020_06_17_156679	67	48	)	)	-RRB-
10_1101-2020_06_17_156679	67	49	,	,	,
10_1101-2020_06_17_156679	67	50	5R83	5r83	CD
10_1101-2020_06_17_156679	67	51	138	138	CD
10_1101-2020_06_17_156679	67	52	(	(	-LRB-
10_1101-2020_06_17_156679	67	53	x0434	x0434	NNP
10_1101-2020_06_17_156679	67	54	)	)	-RRB-
10_1101-2020_06_17_156679	67	55	and	and	CC
10_1101-2020_06_17_156679	67	56	5REH	5REH	NNP
10_1101-2020_06_17_156679	67	57	(	(	-LRB-
10_1101-2020_06_17_156679	67	58	x0540	x0540	NNP
10_1101-2020_06_17_156679	67	59	)	)	-RRB-
10_1101-2020_06_17_156679	67	60	for	for	IN
10_1101-2020_06_17_156679	67	61	MD	MD	NNP
10_1101-2020_06_17_156679	67	62	simulations	simulation	NNS
10_1101-2020_06_17_156679	67	63	with	with	IN
10_1101-2020_06_17_156679	67	64	GROMACS	GROMACS	NNP
10_1101-2020_06_17_156679	67	65	version	version	NN
10_1101-2020_06_17_156679	67	66	2018	2018	CD
10_1101-2020_06_17_156679	67	67	(	(	-LRB-
10_1101-2020_06_17_156679	67	68	25	25	CD
10_1101-2020_06_17_156679	67	69	)	)	-RRB-
10_1101-2020_06_17_156679	67	70	and	and	CC
10_1101-2020_06_17_156679	67	71	the	the	DT
10_1101-2020_06_17_156679	67	72	139	139	CD
10_1101-2020_06_17_156679	67	73	AMBER99SB	AMBER99SB	NNPS
10_1101-2020_06_17_156679	67	74	-	-	HYPH
10_1101-2020_06_17_156679	67	75	ILDN	ILDN	NNP
10_1101-2020_06_17_156679	67	76	force	force	NN
10_1101-2020_06_17_156679	67	77	field	field	NN
10_1101-2020_06_17_156679	67	78	(	(	-LRB-
10_1101-2020_06_17_156679	67	79	26	26	CD
10_1101-2020_06_17_156679	67	80	)	)	-RRB-
10_1101-2020_06_17_156679	67	81	.	.	.
10_1101-2020_06_17_156679	68	1	All	all	DT
10_1101-2020_06_17_156679	68	2	complexes	complex	NNS
10_1101-2020_06_17_156679	68	3	were	be	VBD
10_1101-2020_06_17_156679	68	4	inserted	insert	VBN
10_1101-2020_06_17_156679	68	5	in	in	IN
10_1101-2020_06_17_156679	68	6	a	a	DT
10_1101-2020_06_17_156679	68	7	pre	pre	JJ
10_1101-2020_06_17_156679	68	8	-	-	JJ
10_1101-2020_06_17_156679	68	9	equilibrated	equilibrated	JJ
10_1101-2020_06_17_156679	68	10	box	box	NN
10_1101-2020_06_17_156679	68	11	containing	contain	VBG
10_1101-2020_06_17_156679	68	12	140	140	CD
10_1101-2020_06_17_156679	68	13	water	water	NN
10_1101-2020_06_17_156679	68	14	implemented	implement	VBD
10_1101-2020_06_17_156679	68	15	using	use	VBG
10_1101-2020_06_17_156679	68	16	the	the	DT
10_1101-2020_06_17_156679	68	17	TIP3P	TIP3P	NNP
10_1101-2020_06_17_156679	68	18	water	water	NN
10_1101-2020_06_17_156679	68	19	model	model	NN
10_1101-2020_06_17_156679	68	20	(	(	-LRB-
10_1101-2020_06_17_156679	68	21	26	26	CD
10_1101-2020_06_17_156679	68	22	)	)	-RRB-
10_1101-2020_06_17_156679	68	23	.	.	.
10_1101-2020_06_17_156679	69	1	Force	force	NN
10_1101-2020_06_17_156679	69	2	field	field	NN
10_1101-2020_06_17_156679	69	3	parameters	parameter	NNS
10_1101-2020_06_17_156679	69	4	for	for	IN
10_1101-2020_06_17_156679	69	5	the	the	DT
10_1101-2020_06_17_156679	69	6	six	six	CD
10_1101-2020_06_17_156679	69	7	ligands	ligand	NNS
10_1101-2020_06_17_156679	69	8	141	141	CD
10_1101-2020_06_17_156679	69	9	were	be	VBD
10_1101-2020_06_17_156679	69	10	generated	generate	VBN
10_1101-2020_06_17_156679	69	11	using	use	VBG
10_1101-2020_06_17_156679	69	12	the	the	DT
10_1101-2020_06_17_156679	69	13	general	general	JJ
10_1101-2020_06_17_156679	69	14	Amber	Amber	NNP
10_1101-2020_06_17_156679	69	15	force	force	NN
10_1101-2020_06_17_156679	69	16	field	field	NN
10_1101-2020_06_17_156679	69	17	and	and	CC
10_1101-2020_06_17_156679	69	18	HF/6	HF/6	NNS
10_1101-2020_06_17_156679	69	19	–	–	:
10_1101-2020_06_17_156679	69	20	31	31	CD
10_1101-2020_06_17_156679	69	21	G	g	NN
10_1101-2020_06_17_156679	69	22	*	*	NFP
10_1101-2020_06_17_156679	69	23	–	–	:
10_1101-2020_06_17_156679	69	24	derived	derive	VBN
10_1101-2020_06_17_156679	69	25	RESP	RESP	NNP
10_1101-2020_06_17_156679	69	26	atomic	atomic	JJ
10_1101-2020_06_17_156679	69	27	charges	charge	NNS
10_1101-2020_06_17_156679	69	28	142	142	CD
10_1101-2020_06_17_156679	69	29	(	(	-LRB-
10_1101-2020_06_17_156679	69	30	27	27	CD
10_1101-2020_06_17_156679	69	31	)	)	-RRB-
10_1101-2020_06_17_156679	69	32	.	.	.
10_1101-2020_06_17_156679	70	1	The	the	DT
10_1101-2020_06_17_156679	70	2	reference	reference	NN
10_1101-2020_06_17_156679	70	3	system	system	NN
10_1101-2020_06_17_156679	70	4	consisted	consist	VBD
10_1101-2020_06_17_156679	70	5	of	of	IN
10_1101-2020_06_17_156679	70	6	the	the	DT
10_1101-2020_06_17_156679	70	7	protein	protein	NN
10_1101-2020_06_17_156679	70	8	,	,	,
10_1101-2020_06_17_156679	70	9	the	the	DT
10_1101-2020_06_17_156679	70	10	ligand	ligand	NN
10_1101-2020_06_17_156679	70	11	,	,	,
10_1101-2020_06_17_156679	70	12	~31,400	~31,400	NNP
10_1101-2020_06_17_156679	70	13	water	water	NN
10_1101-2020_06_17_156679	70	14	molecules	molecule	NNS
10_1101-2020_06_17_156679	70	15	,	,	,
10_1101-2020_06_17_156679	70	16	95	95	CD
10_1101-2020_06_17_156679	70	17	Na	Na	NNS
10_1101-2020_06_17_156679	70	18	and	and	CC
10_1101-2020_06_17_156679	70	19	143	143	CD
10_1101-2020_06_17_156679	70	20	95	95	CD
10_1101-2020_06_17_156679	70	21	Cl	Cl	NNP
10_1101-2020_06_17_156679	70	22	ions	ion	NNS
10_1101-2020_06_17_156679	70	23	in	in	IN
10_1101-2020_06_17_156679	70	24	a	a	DT
10_1101-2020_06_17_156679	70	25	100	100	CD
10_1101-2020_06_17_156679	70	26	x	x	SYM
10_1101-2020_06_17_156679	70	27	100	100	CD
10_1101-2020_06_17_156679	70	28	x	x	SYM
10_1101-2020_06_17_156679	70	29	100	100	CD
10_1101-2020_06_17_156679	70	30	Å	å	JJ
10_1101-2020_06_17_156679	70	31	simulation	simulation	NN
10_1101-2020_06_17_156679	70	32	box	box	NN
10_1101-2020_06_17_156679	70	33	,	,	,
10_1101-2020_06_17_156679	70	34	resulting	result	VBG
10_1101-2020_06_17_156679	70	35	in	in	IN
10_1101-2020_06_17_156679	70	36	a	a	DT
10_1101-2020_06_17_156679	70	37	total	total	JJ
10_1101-2020_06_17_156679	70	38	number	number	NN
10_1101-2020_06_17_156679	70	39	of	of	IN
10_1101-2020_06_17_156679	70	40	~98,000	~98,000	NN
10_1101-2020_06_17_156679	70	41	atoms	atom	NNS
10_1101-2020_06_17_156679	70	42	.	.	.
10_1101-2020_06_17_156679	71	1	Each	each	DT
10_1101-2020_06_17_156679	71	2	144	144	CD
10_1101-2020_06_17_156679	71	3	system	system	NN
10_1101-2020_06_17_156679	71	4	was	be	VBD
10_1101-2020_06_17_156679	71	5	energy	energy	NN
10_1101-2020_06_17_156679	71	6	-	-	HYPH
10_1101-2020_06_17_156679	71	7	minimized	minimize	VBN
10_1101-2020_06_17_156679	71	8	and	and	CC
10_1101-2020_06_17_156679	71	9	subsequently	subsequently	RB
10_1101-2020_06_17_156679	71	10	subjected	subject	VBN
10_1101-2020_06_17_156679	71	11	to	to	IN
10_1101-2020_06_17_156679	71	12	a	a	DT
10_1101-2020_06_17_156679	71	13	20	20	CD
10_1101-2020_06_17_156679	71	14	ns	ns	IN
10_1101-2020_06_17_156679	71	15	MD	MD	NNP
10_1101-2020_06_17_156679	71	16	equilibration	equilibration	NN
10_1101-2020_06_17_156679	71	17	,	,	,
10_1101-2020_06_17_156679	71	18	with	with	IN
10_1101-2020_06_17_156679	71	19	an	an	DT
10_1101-2020_06_17_156679	71	20	145	145	CD
10_1101-2020_06_17_156679	71	21	isothermal	isothermal	JJ
10_1101-2020_06_17_156679	71	22	-	-	HYPH
10_1101-2020_06_17_156679	71	23	isobaric	isobaric	JJ
10_1101-2020_06_17_156679	71	24	ensemble	ensemble	JJ
10_1101-2020_06_17_156679	71	25	using	use	VBG
10_1101-2020_06_17_156679	71	26	isotropic	isotropic	JJ
10_1101-2020_06_17_156679	71	27	pressure	pressure	NN
10_1101-2020_06_17_156679	71	28	control	control	NN
10_1101-2020_06_17_156679	71	29	(	(	-LRB-
10_1101-2020_06_17_156679	71	30	28	28	CD
10_1101-2020_06_17_156679	71	31	)	)	-RRB-
10_1101-2020_06_17_156679	71	32	,	,	,
10_1101-2020_06_17_156679	71	33	and	and	CC
10_1101-2020_06_17_156679	71	34	positional	positional	JJ
10_1101-2020_06_17_156679	71	35	restraints	restraint	NNS
10_1101-2020_06_17_156679	71	36	on	on	IN
10_1101-2020_06_17_156679	71	37	146	146	CD
10_1101-2020_06_17_156679	71	38	protein	protein	NN
10_1101-2020_06_17_156679	71	39	and	and	CC
10_1101-2020_06_17_156679	71	40	ligand	ligand	NN
10_1101-2020_06_17_156679	71	41	coordinates	coordinate	NNS
10_1101-2020_06_17_156679	71	42	.	.	.
10_1101-2020_06_17_156679	72	1	The	the	DT
10_1101-2020_06_17_156679	72	2	resulting	result	VBG
10_1101-2020_06_17_156679	72	3	equilibrated	equilibrate	VBN
10_1101-2020_06_17_156679	72	4	systems	system	NNS
10_1101-2020_06_17_156679	72	5	were	be	VBD
10_1101-2020_06_17_156679	72	6	replicated	replicate	VBN
10_1101-2020_06_17_156679	72	7	4	4	CD
10_1101-2020_06_17_156679	72	8	times	time	NNS
10_1101-2020_06_17_156679	72	9	and	and	CC
10_1101-2020_06_17_156679	72	10	147	147	CD
10_1101-2020_06_17_156679	72	11	independent	independent	JJ
10_1101-2020_06_17_156679	72	12	200	200	CD
10_1101-2020_06_17_156679	72	13	ns	ns	IN
10_1101-2020_06_17_156679	72	14	MD	MD	NNP
10_1101-2020_06_17_156679	72	15	trajectories	trajectory	NNS
10_1101-2020_06_17_156679	72	16	were	be	VBD
10_1101-2020_06_17_156679	72	17	produced	produce	VBN
10_1101-2020_06_17_156679	72	18	with	with	IN
10_1101-2020_06_17_156679	72	19	a	a	DT
10_1101-2020_06_17_156679	72	20	time	time	NN
10_1101-2020_06_17_156679	72	21	step	step	NN
10_1101-2020_06_17_156679	72	22	of	of	IN
10_1101-2020_06_17_156679	72	23	2	2	CD
10_1101-2020_06_17_156679	72	24	fs	f	NNS
10_1101-2020_06_17_156679	72	25	,	,	,
10_1101-2020_06_17_156679	72	26	in	in	IN
10_1101-2020_06_17_156679	72	27	constant	constant	JJ
10_1101-2020_06_17_156679	72	28	temperature	temperature	NN
10_1101-2020_06_17_156679	72	29	148	148	CD
10_1101-2020_06_17_156679	72	30	of	of	IN
10_1101-2020_06_17_156679	72	31	300	300	CD
10_1101-2020_06_17_156679	72	32	K	K	NNP
10_1101-2020_06_17_156679	72	33	,	,	,
10_1101-2020_06_17_156679	72	34	using	use	VBG
10_1101-2020_06_17_156679	72	35	separate	separate	JJ
10_1101-2020_06_17_156679	72	36	v	v	NNP
10_1101-2020_06_17_156679	72	37	-	-	HYPH
10_1101-2020_06_17_156679	72	38	rescale	rescale	NN
10_1101-2020_06_17_156679	72	39	thermostats	thermostat	NNS
10_1101-2020_06_17_156679	72	40	(	(	-LRB-
10_1101-2020_06_17_156679	72	41	28	28	CD
10_1101-2020_06_17_156679	72	42	)	)	-RRB-
10_1101-2020_06_17_156679	72	43	for	for	IN
10_1101-2020_06_17_156679	72	44	the	the	DT
10_1101-2020_06_17_156679	72	45	protein	protein	NN
10_1101-2020_06_17_156679	72	46	,	,	,
10_1101-2020_06_17_156679	72	47	ligand	ligand	NNP
10_1101-2020_06_17_156679	72	48	and	and	CC
10_1101-2020_06_17_156679	72	49	solvent	solvent	NNP
10_1101-2020_06_17_156679	72	50	molecules	molecule	NNS
10_1101-2020_06_17_156679	72	51	.	.	.
10_1101-2020_06_17_156679	73	1	149	149	CD
10_1101-2020_06_17_156679	73	2	Lennard	Lennard	NNP
10_1101-2020_06_17_156679	73	3	-	-	HYPH
10_1101-2020_06_17_156679	73	4	Jones	Jones	NNP
10_1101-2020_06_17_156679	73	5	interactions	interaction	NNS
10_1101-2020_06_17_156679	73	6	were	be	VBD
10_1101-2020_06_17_156679	73	7	computed	compute	VBN
10_1101-2020_06_17_156679	73	8	using	use	VBG
10_1101-2020_06_17_156679	73	9	a	a	DT
10_1101-2020_06_17_156679	73	10	cut	cut	NN
10_1101-2020_06_17_156679	73	11	-	-	HYPH
10_1101-2020_06_17_156679	73	12	off	off	NN
10_1101-2020_06_17_156679	73	13	of	of	IN
10_1101-2020_06_17_156679	73	14	10	10	CD
10_1101-2020_06_17_156679	73	15	Å	Å	NNP
10_1101-2020_06_17_156679	73	16	and	and	CC
10_1101-2020_06_17_156679	73	17	electrosta	electrosta	NNP
10_1101-2020_06_17_156679	73	18	�	�	.
10_1101-2020_06_17_156679	73	19	c	c	NNP
10_1101-2020_06_17_156679	73	20	interac	interac	NN
10_1101-2020_06_17_156679	73	21	�	�	NNP
10_1101-2020_06_17_156679	73	22	ons	ons	NN
10_1101-2020_06_17_156679	73	23	were	be	VBD
10_1101-2020_06_17_156679	73	24	150	150	CD
10_1101-2020_06_17_156679	73	25	treated	treat	VBN
10_1101-2020_06_17_156679	73	26	using	use	VBG
10_1101-2020_06_17_156679	73	27	particle	particle	NN
10_1101-2020_06_17_156679	73	28	mesh	mesh	NN
10_1101-2020_06_17_156679	73	29	Ewald	Ewald	NNP
10_1101-2020_06_17_156679	73	30	(	(	-LRB-
10_1101-2020_06_17_156679	73	31	29	29	CD
10_1101-2020_06_17_156679	73	32	)	)	-RRB-
10_1101-2020_06_17_156679	73	33	with	with	IN
10_1101-2020_06_17_156679	73	34	the	the	DT
10_1101-2020_06_17_156679	73	35	same	same	JJ
10_1101-2020_06_17_156679	73	36	real	real	JJ
10_1101-2020_06_17_156679	73	37	-	-	HYPH
10_1101-2020_06_17_156679	73	38	space	space	NN
10_1101-2020_06_17_156679	73	39	cut	cut	NN
10_1101-2020_06_17_156679	73	40	-	-	HYPH
10_1101-2020_06_17_156679	73	41	off	off	RP
10_1101-2020_06_17_156679	73	42	.	.	.
10_1101-2020_06_17_156679	74	1	Analysis	analysis	NN
10_1101-2020_06_17_156679	74	2	on	on	IN
10_1101-2020_06_17_156679	74	3	the	the	DT
10_1101-2020_06_17_156679	74	4	resulting	result	VBG
10_1101-2020_06_17_156679	74	5	151	151	CD
10_1101-2020_06_17_156679	74	6	trajectories	trajectory	NNS
10_1101-2020_06_17_156679	74	7	was	be	VBD
10_1101-2020_06_17_156679	74	8	performed	perform	VBN
10_1101-2020_06_17_156679	74	9	using	use	VBG
10_1101-2020_06_17_156679	74	10	MDAnalysis	mdanalysis	NN
10_1101-2020_06_17_156679	74	11	(	(	-LRB-
10_1101-2020_06_17_156679	74	12	30	30	CD
10_1101-2020_06_17_156679	74	13	,	,	,
10_1101-2020_06_17_156679	74	14	31	31	CD
10_1101-2020_06_17_156679	74	15	)	)	-RRB-
10_1101-2020_06_17_156679	74	16	.	.	.
10_1101-2020_06_17_156679	75	1	Structures	structure	NNS
10_1101-2020_06_17_156679	75	2	were	be	VBD
10_1101-2020_06_17_156679	75	3	visualised	visualise	VBN
10_1101-2020_06_17_156679	75	4	using	use	VBG
10_1101-2020_06_17_156679	75	5	PyMOL	PyMOL	NNP
10_1101-2020_06_17_156679	75	6	(	(	-LRB-
10_1101-2020_06_17_156679	75	7	32	32	CD
10_1101-2020_06_17_156679	75	8	)	)	-RRB-
10_1101-2020_06_17_156679	75	9	.	.	.
10_1101-2020_06_17_156679	76	1	152	152	CD
10_1101-2020_06_17_156679	76	2	153	153	CD
10_1101-2020_06_17_156679	76	3	Notes	note	NNS
10_1101-2020_06_17_156679	76	4	154	154	CD
10_1101-2020_06_17_156679	76	5	The	the	DT
10_1101-2020_06_17_156679	76	6	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	76	7	inhibition	inhibition	NN
10_1101-2020_06_17_156679	76	8	potential	potential	NN
10_1101-2020_06_17_156679	76	9	of	of	IN
10_1101-2020_06_17_156679	76	10	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	76	11	ligands	ligand	NNS
10_1101-2020_06_17_156679	76	12	,	,	,
10_1101-2020_06_17_156679	76	13	measured	measure	VBN
10_1101-2020_06_17_156679	76	14	by	by	IN
10_1101-2020_06_17_156679	76	15	RapidFire	RapidFire	NNP
10_1101-2020_06_17_156679	76	16	mass	mass	NN
10_1101-2020_06_17_156679	76	17	spectroscopy	spectroscopy	NN
10_1101-2020_06_17_156679	76	18	155	155	CD
10_1101-2020_06_17_156679	76	19	(	(	-LRB-
10_1101-2020_06_17_156679	76	20	17	17	CD
10_1101-2020_06_17_156679	76	21	)	)	-RRB-
10_1101-2020_06_17_156679	76	22	,	,	,
10_1101-2020_06_17_156679	76	23	was	be	VBD
10_1101-2020_06_17_156679	76	24	retrieved	retrieve	VBN
10_1101-2020_06_17_156679	76	25	from	from	IN
10_1101-2020_06_17_156679	76	26	the	the	DT
10_1101-2020_06_17_156679	76	27	Collaborative	Collaborative	NNP
10_1101-2020_06_17_156679	76	28	Drug	Drug	NNP
10_1101-2020_06_17_156679	76	29	Discovery	Discovery	NNP
10_1101-2020_06_17_156679	76	30	database	database	NN
10_1101-2020_06_17_156679	76	31	(	(	-LRB-
10_1101-2020_06_17_156679	76	32	33	33	CD
10_1101-2020_06_17_156679	76	33	)	)	-RRB-
10_1101-2020_06_17_156679	76	34	.	.	.
10_1101-2020_06_17_156679	77	1	156	156	CD
10_1101-2020_06_17_156679	77	2	157	157	CD
10_1101-2020_06_17_156679	77	3	.CC	.CC	:
10_1101-2020_06_17_156679	77	4	-	-	:
10_1101-2020_06_17_156679	77	5	BY	by	IN
10_1101-2020_06_17_156679	77	6	4.0	4.0	CD
10_1101-2020_06_17_156679	77	7	International	International	NNP
10_1101-2020_06_17_156679	77	8	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	77	9	under	under	IN
10_1101-2020_06_17_156679	77	10	a	a	DT
10_1101-2020_06_17_156679	77	11	(	(	-LRB-
10_1101-2020_06_17_156679	77	12	which	which	WDT
10_1101-2020_06_17_156679	77	13	was	be	VBD
10_1101-2020_06_17_156679	77	14	not	not	RB
10_1101-2020_06_17_156679	77	15	certified	certify	VBN
10_1101-2020_06_17_156679	77	16	by	by	IN
10_1101-2020_06_17_156679	77	17	peer	peer	NN
10_1101-2020_06_17_156679	77	18	review	review	NN
10_1101-2020_06_17_156679	77	19	)	)	-RRB-
10_1101-2020_06_17_156679	77	20	is	be	VBZ
10_1101-2020_06_17_156679	77	21	the	the	DT
10_1101-2020_06_17_156679	77	22	author	author	NN
10_1101-2020_06_17_156679	77	23	/	/	SYM
10_1101-2020_06_17_156679	77	24	funder	funder	NN
10_1101-2020_06_17_156679	77	25	,	,	,
10_1101-2020_06_17_156679	77	26	who	who	WP
10_1101-2020_06_17_156679	77	27	has	have	VBZ
10_1101-2020_06_17_156679	77	28	granted	grant	VBN
10_1101-2020_06_17_156679	77	29	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	77	30	a	a	DT
10_1101-2020_06_17_156679	77	31	license	license	NN
10_1101-2020_06_17_156679	77	32	to	to	TO
10_1101-2020_06_17_156679	77	33	display	display	VB
10_1101-2020_06_17_156679	77	34	the	the	DT
10_1101-2020_06_17_156679	77	35	preprint	preprint	NN
10_1101-2020_06_17_156679	77	36	in	in	IN
10_1101-2020_06_17_156679	77	37	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	77	38	.	.	.
10_1101-2020_06_17_156679	78	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	78	2	is	be	VBZ
10_1101-2020_06_17_156679	78	3	made	make	VBN
10_1101-2020_06_17_156679	78	4	The	the	DT
10_1101-2020_06_17_156679	78	5	copyright	copyright	NN
10_1101-2020_06_17_156679	78	6	holder	holder	NN
10_1101-2020_06_17_156679	78	7	for	for	IN
10_1101-2020_06_17_156679	78	8	this	this	DT
10_1101-2020_06_17_156679	78	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	78	10	version	version	NN
10_1101-2020_06_17_156679	78	11	posted	post	VBD
10_1101-2020_06_17_156679	78	12	January	January	NNP
10_1101-2020_06_17_156679	78	13	6	6	CD
10_1101-2020_06_17_156679	78	14	,	,	,
10_1101-2020_06_17_156679	78	15	2021	2021	CD
10_1101-2020_06_17_156679	78	16	.	.	.
10_1101-2020_06_17_156679	78	17	;	;	:
10_1101-2020_06_17_156679	78	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	78	19	:	:	:
10_1101-2020_06_17_156679	78	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	78	21	preprint	preprint	NN
10_1101-2020_06_17_156679	78	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	78	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	78	24	7	7	CD
10_1101-2020_06_17_156679	78	25	Results	result	NNS
10_1101-2020_06_17_156679	78	26	158	158	CD
10_1101-2020_06_17_156679	78	27	STD	STD	NNP
10_1101-2020_06_17_156679	78	28	-	-	HYPH
10_1101-2020_06_17_156679	78	29	NMR	NMR	NNP
10_1101-2020_06_17_156679	78	30	assays	assays	RB
10_1101-2020_06_17_156679	78	31	of	of	IN
10_1101-2020_06_17_156679	78	32	M	M	NNP
10_1101-2020_06_17_156679	78	33	pro	pro	JJ
10_1101-2020_06_17_156679	78	34	ligand	ligand	NNP
10_1101-2020_06_17_156679	78	35	binding	bind	VBG
10_1101-2020_06_17_156679	78	36	159	159	CD
10_1101-2020_06_17_156679	78	37	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	78	38	forms	form	NNS
10_1101-2020_06_17_156679	78	39	dimers	dimer	NNS
10_1101-2020_06_17_156679	78	40	in	in	IN
10_1101-2020_06_17_156679	78	41	crystals	crystal	NNS
10_1101-2020_06_17_156679	78	42	via	via	IN
10_1101-2020_06_17_156679	78	43	an	an	DT
10_1101-2020_06_17_156679	78	44	extensive	extensive	JJ
10_1101-2020_06_17_156679	78	45	interaction	interaction	NN
10_1101-2020_06_17_156679	78	46	interface	interface	NN
10_1101-2020_06_17_156679	78	47	involving	involve	VBG
10_1101-2020_06_17_156679	78	48	two	two	CD
10_1101-2020_06_17_156679	78	49	domains	domain	NNS
10_1101-2020_06_17_156679	78	50	(	(	-LRB-
10_1101-2020_06_17_156679	78	51	15	15	CD
10_1101-2020_06_17_156679	78	52	)	)	-RRB-
10_1101-2020_06_17_156679	78	53	.	.	.
10_1101-2020_06_17_156679	79	1	160	160	CD
10_1101-2020_06_17_156679	79	2	Mpro	mpro	JJ
10_1101-2020_06_17_156679	79	3	dimers	dimer	NNS
10_1101-2020_06_17_156679	79	4	likely	likely	RB
10_1101-2020_06_17_156679	79	5	have	have	VBP
10_1101-2020_06_17_156679	79	6	a	a	DT
10_1101-2020_06_17_156679	79	7	sub	sub	JJ
10_1101-2020_06_17_156679	79	8	-	-	HYPH
10_1101-2020_06_17_156679	79	9	μM	μm	NN
10_1101-2020_06_17_156679	79	10	solution	solution	NN
10_1101-2020_06_17_156679	79	11	dissociation	dissociation	NN
10_1101-2020_06_17_156679	79	12	constant	constant	NN
10_1101-2020_06_17_156679	79	13	(	(	-LRB-
10_1101-2020_06_17_156679	79	14	Kd	Kd	NNP
10_1101-2020_06_17_156679	79	15	)	)	-RRB-
10_1101-2020_06_17_156679	79	16	by	by	IN
10_1101-2020_06_17_156679	79	17	analogy	analogy	NN
10_1101-2020_06_17_156679	79	18	to	to	TO
10_1101-2020_06_17_156679	79	19	previously	previously	RB
10_1101-2020_06_17_156679	79	20	studied	study	VBD
10_1101-2020_06_17_156679	79	21	161	161	CD
10_1101-2020_06_17_156679	79	22	3C	3c	NN
10_1101-2020_06_17_156679	79	23	-	-	HYPH
10_1101-2020_06_17_156679	79	24	like	like	JJ
10_1101-2020_06_17_156679	79	25	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	79	26	proteases	protease	NNS
10_1101-2020_06_17_156679	79	27	(	(	-LRB-
10_1101-2020_06_17_156679	79	28	34	34	CD
10_1101-2020_06_17_156679	79	29	)	)	-RRB-
10_1101-2020_06_17_156679	79	30	.	.	.
10_1101-2020_06_17_156679	80	1	At	at	IN
10_1101-2020_06_17_156679	80	2	the	the	DT
10_1101-2020_06_17_156679	80	3	10	10	CD
10_1101-2020_06_17_156679	80	4	μM	μM	NNP
10_1101-2020_06_17_156679	80	5	protein	protein	NN
10_1101-2020_06_17_156679	80	6	concentration	concentration	NN
10_1101-2020_06_17_156679	80	7	of	of	IN
10_1101-2020_06_17_156679	80	8	our	-PRON-	PRP$
10_1101-2020_06_17_156679	80	9	NMR	NMR	NNP
10_1101-2020_06_17_156679	80	10	assays	assays	RB
10_1101-2020_06_17_156679	80	11	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	80	12	is	be	VBZ
10_1101-2020_06_17_156679	80	13	,	,	,
10_1101-2020_06_17_156679	80	14	162	162	CD
10_1101-2020_06_17_156679	80	15	thus	thus	RB
10_1101-2020_06_17_156679	80	16	,	,	,
10_1101-2020_06_17_156679	80	17	expected	expect	VBN
10_1101-2020_06_17_156679	80	18	to	to	TO
10_1101-2020_06_17_156679	80	19	be	be	VB
10_1101-2020_06_17_156679	80	20	dimeric	dimeric	JJ
10_1101-2020_06_17_156679	80	21	with	with	IN
10_1101-2020_06_17_156679	80	22	an	an	DT
10_1101-2020_06_17_156679	80	23	estimated	estimate	VBN
10_1101-2020_06_17_156679	80	24	molecular	molecular	JJ
10_1101-2020_06_17_156679	80	25	weight	weight	NN
10_1101-2020_06_17_156679	80	26	of	of	IN
10_1101-2020_06_17_156679	80	27	nearly	nearly	RB
10_1101-2020_06_17_156679	80	28	70	70	CD
10_1101-2020_06_17_156679	80	29	kDa	kDa	NNS
10_1101-2020_06_17_156679	80	30	.	.	.
10_1101-2020_06_17_156679	81	1	Despite	despite	IN
10_1101-2020_06_17_156679	81	2	the	the	DT
10_1101-2020_06_17_156679	81	3	163	163	CD
10_1101-2020_06_17_156679	81	4	relatively	relatively	RB
10_1101-2020_06_17_156679	81	5	large	large	JJ
10_1101-2020_06_17_156679	81	6	size	size	NN
10_1101-2020_06_17_156679	81	7	of	of	IN
10_1101-2020_06_17_156679	81	8	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	81	9	for	for	IN
10_1101-2020_06_17_156679	81	10	solution	solution	NN
10_1101-2020_06_17_156679	81	11	NMR	NMR	NNP
10_1101-2020_06_17_156679	81	12	,	,	,
10_1101-2020_06_17_156679	81	13	1H	1h	JJ
10_1101-2020_06_17_156679	81	14	spectra	spectra	NN
10_1101-2020_06_17_156679	81	15	of	of	IN
10_1101-2020_06_17_156679	81	16	the	the	DT
10_1101-2020_06_17_156679	81	17	protease	protease	NN
10_1101-2020_06_17_156679	81	18	readily	readily	RB
10_1101-2020_06_17_156679	81	19	showed	show	VBD
10_1101-2020_06_17_156679	81	20	the	the	DT
10_1101-2020_06_17_156679	81	21	presence	presence	NN
10_1101-2020_06_17_156679	81	22	164	164	CD
10_1101-2020_06_17_156679	81	23	of	of	IN
10_1101-2020_06_17_156679	81	24	multiple	multiple	JJ
10_1101-2020_06_17_156679	81	25	up	up	JJ
10_1101-2020_06_17_156679	81	26	-	-	HYPH
10_1101-2020_06_17_156679	81	27	field	field	NN
10_1101-2020_06_17_156679	81	28	shifted	shift	VBN
10_1101-2020_06_17_156679	81	29	(	(	-LRB-
10_1101-2020_06_17_156679	81	30	<	<	XX
10_1101-2020_06_17_156679	81	31	0.5	0.5	CD
10_1101-2020_06_17_156679	81	32	ppm	ppm	NNP
10_1101-2020_06_17_156679	81	33	)	)	-RRB-
10_1101-2020_06_17_156679	81	34	peaks	peak	VBZ
10_1101-2020_06_17_156679	81	35	corresponding	correspond	VBG
10_1101-2020_06_17_156679	81	36	to	to	IN
10_1101-2020_06_17_156679	81	37	protein	protein	NN
10_1101-2020_06_17_156679	81	38	methyl	methyl	NN
10_1101-2020_06_17_156679	81	39	groups	group	NNS
10_1101-2020_06_17_156679	81	40	(	(	-LRB-
10_1101-2020_06_17_156679	81	41	Fig	fig	NN
10_1101-2020_06_17_156679	81	42	.	.	.
10_1101-2020_06_17_156679	82	1	1A	1a	LS
10_1101-2020_06_17_156679	82	2	)	)	-RRB-
10_1101-2020_06_17_156679	82	3	.	.	.
10_1101-2020_06_17_156679	83	1	In	in	IN
10_1101-2020_06_17_156679	83	2	165	165	CD
10_1101-2020_06_17_156679	83	3	addition	addition	NN
10_1101-2020_06_17_156679	83	4	to	to	IN
10_1101-2020_06_17_156679	83	5	demonstrating	demonstrate	VBG
10_1101-2020_06_17_156679	83	6	that	that	IN
10_1101-2020_06_17_156679	83	7	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	83	8	is	be	VBZ
10_1101-2020_06_17_156679	83	9	folded	fold	VBN
10_1101-2020_06_17_156679	83	10	under	under	IN
10_1101-2020_06_17_156679	83	11	the	the	DT
10_1101-2020_06_17_156679	83	12	conditions	condition	NNS
10_1101-2020_06_17_156679	83	13	tested	test	VBN
10_1101-2020_06_17_156679	83	14	,	,	,
10_1101-2020_06_17_156679	83	15	these	these	DT
10_1101-2020_06_17_156679	83	16	spectra	spectra	NNP
10_1101-2020_06_17_156679	83	17	allowed	allow	VBD
10_1101-2020_06_17_156679	83	18	us	-PRON-	PRP
10_1101-2020_06_17_156679	83	19	166	166	CD
10_1101-2020_06_17_156679	83	20	to	to	TO
10_1101-2020_06_17_156679	83	21	identify	identify	VB
10_1101-2020_06_17_156679	83	22	the	the	DT
10_1101-2020_06_17_156679	83	23	chemical	chemical	NN
10_1101-2020_06_17_156679	83	24	shifts	shift	NNS
10_1101-2020_06_17_156679	83	25	of	of	IN
10_1101-2020_06_17_156679	83	26	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	83	27	methyl	methyl	NN
10_1101-2020_06_17_156679	83	28	groups	group	NNS
10_1101-2020_06_17_156679	83	29	that	that	WDT
10_1101-2020_06_17_156679	83	30	may	may	MD
10_1101-2020_06_17_156679	83	31	be	be	VB
10_1101-2020_06_17_156679	83	32	suitable	suitable	JJ
10_1101-2020_06_17_156679	83	33	for	for	IN
10_1101-2020_06_17_156679	83	34	on	on	IN
10_1101-2020_06_17_156679	83	35	-	-	HYPH
10_1101-2020_06_17_156679	83	36	resonance	resonance	NN
10_1101-2020_06_17_156679	83	37	167	167	CD
10_1101-2020_06_17_156679	83	38	irradiation	irradiation	NN
10_1101-2020_06_17_156679	83	39	in	in	IN
10_1101-2020_06_17_156679	83	40	STD	STD	NNP
10_1101-2020_06_17_156679	83	41	-	-	HYPH
10_1101-2020_06_17_156679	83	42	NMR	NMR	NNP
10_1101-2020_06_17_156679	83	43	experiments	experiment	NNS
10_1101-2020_06_17_156679	83	44	.	.	.
10_1101-2020_06_17_156679	84	1	Trials	trial	NNS
10_1101-2020_06_17_156679	84	2	with	with	IN
10_1101-2020_06_17_156679	84	3	on	on	IN
10_1101-2020_06_17_156679	84	4	-	-	HYPH
10_1101-2020_06_17_156679	84	5	resonance	resonance	NN
10_1101-2020_06_17_156679	84	6	irradiation	irradiation	NN
10_1101-2020_06_17_156679	84	7	applied	apply	VBD
10_1101-2020_06_17_156679	84	8	to	to	IN
10_1101-2020_06_17_156679	84	9	different	different	JJ
10_1101-2020_06_17_156679	84	10	methyl	methyl	NN
10_1101-2020_06_17_156679	84	11	168	168	CD
10_1101-2020_06_17_156679	84	12	group	group	NN
10_1101-2020_06_17_156679	84	13	peaks	peak	NNS
10_1101-2020_06_17_156679	84	14	showed	show	VBD
10_1101-2020_06_17_156679	84	15	that	that	IN
10_1101-2020_06_17_156679	84	16	irradiating	irradiate	VBG
10_1101-2020_06_17_156679	84	17	at	at	IN
10_1101-2020_06_17_156679	84	18	0.5	0.5	CD
10_1101-2020_06_17_156679	84	19	ppm	ppm	NN
10_1101-2020_06_17_156679	84	20	(	(	-LRB-
10_1101-2020_06_17_156679	84	21	Fig	fig	NN
10_1101-2020_06_17_156679	84	22	.	.	.
10_1101-2020_06_17_156679	85	1	1A	1a	LS
10_1101-2020_06_17_156679	85	2	)	)	-RRB-
10_1101-2020_06_17_156679	85	3	produced	produce	VBD
10_1101-2020_06_17_156679	85	4	the	the	DT
10_1101-2020_06_17_156679	85	5	strongest	strong	JJS
10_1101-2020_06_17_156679	85	6	STD	STD	NNP
10_1101-2020_06_17_156679	85	7	signal	signal	NN
10_1101-2020_06_17_156679	85	8	from	from	IN
10_1101-2020_06_17_156679	85	9	169	169	CD
10_1101-2020_06_17_156679	85	10	ligands	ligand	NNS
10_1101-2020_06_17_156679	85	11	in	in	IN
10_1101-2020_06_17_156679	85	12	the	the	DT
10_1101-2020_06_17_156679	85	13	presence	presence	NN
10_1101-2020_06_17_156679	85	14	of	of	IN
10_1101-2020_06_17_156679	85	15	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	85	16	,	,	,
10_1101-2020_06_17_156679	85	17	while	while	IN
10_1101-2020_06_17_156679	85	18	simultaneously	simultaneously	RB
10_1101-2020_06_17_156679	85	19	avoiding	avoid	VBG
10_1101-2020_06_17_156679	85	20	ligand	ligand	NN
10_1101-2020_06_17_156679	85	21	excitation	excitation	NN
10_1101-2020_06_17_156679	85	22	that	that	WDT
10_1101-2020_06_17_156679	85	23	would	would	MD
10_1101-2020_06_17_156679	85	24	yield	yield	VB
10_1101-2020_06_17_156679	85	25	170	170	CD
10_1101-2020_06_17_156679	85	26	false	false	JJ
10_1101-2020_06_17_156679	85	27	-	-	HYPH
10_1101-2020_06_17_156679	85	28	positive	positive	JJ
10_1101-2020_06_17_156679	85	29	signals	signal	NNS
10_1101-2020_06_17_156679	85	30	in	in	IN
10_1101-2020_06_17_156679	85	31	the	the	DT
10_1101-2020_06_17_156679	85	32	absence	absence	NN
10_1101-2020_06_17_156679	85	33	of	of	IN
10_1101-2020_06_17_156679	85	34	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	85	35	(	(	-LRB-
10_1101-2020_06_17_156679	85	36	Fig	fig	NN
10_1101-2020_06_17_156679	85	37	.	.	.
10_1101-2020_06_17_156679	86	1	1B	1B	NNP
10_1101-2020_06_17_156679	86	2	)	)	-RRB-
10_1101-2020_06_17_156679	86	3	.	.	.
10_1101-2020_06_17_156679	87	1	Further	further	RB
10_1101-2020_06_17_156679	87	2	,	,	,
10_1101-2020_06_17_156679	87	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	87	4	noted	note	VBD
10_1101-2020_06_17_156679	87	5	that	that	IN
10_1101-2020_06_17_156679	87	6	small	small	JJ
10_1101-2020_06_17_156679	87	7	molecules	molecule	NNS
10_1101-2020_06_17_156679	87	8	171	171	CD
10_1101-2020_06_17_156679	87	9	abundant	abundant	JJ
10_1101-2020_06_17_156679	87	10	in	in	IN
10_1101-2020_06_17_156679	87	11	the	the	DT
10_1101-2020_06_17_156679	87	12	samples	sample	NNS
10_1101-2020_06_17_156679	87	13	but	but	CC
10_1101-2020_06_17_156679	87	14	not	not	RB
10_1101-2020_06_17_156679	87	15	binding	bind	VBG
10_1101-2020_06_17_156679	87	16	specifically	specifically	RB
10_1101-2020_06_17_156679	87	17	to	to	IN
10_1101-2020_06_17_156679	87	18	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	87	19	,	,	,
10_1101-2020_06_17_156679	87	20	such	such	JJ
10_1101-2020_06_17_156679	87	21	as	as	IN
10_1101-2020_06_17_156679	87	22	DMSO	DMSO	NNP
10_1101-2020_06_17_156679	87	23	,	,	,
10_1101-2020_06_17_156679	87	24	produced	produce	VBD
10_1101-2020_06_17_156679	87	25	pseudo-172	pseudo-172	NNP
10_1101-2020_06_17_156679	87	26	dispersive	dispersive	JJ
10_1101-2020_06_17_156679	87	27	residual	residual	JJ
10_1101-2020_06_17_156679	87	28	signal	signal	NN
10_1101-2020_06_17_156679	87	29	lineshapes	lineshape	NNS
10_1101-2020_06_17_156679	87	30	in	in	IN
10_1101-2020_06_17_156679	87	31	STD	STD	NNP
10_1101-2020_06_17_156679	87	32	spectra	spectra	NNP
10_1101-2020_06_17_156679	87	33	,	,	,
10_1101-2020_06_17_156679	87	34	while	while	IN
10_1101-2020_06_17_156679	87	35	true	true	JJ
10_1101-2020_06_17_156679	87	36	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	87	37	ligands	ligand	VBZ
10_1101-2020_06_17_156679	87	38	produced	produce	VBD
10_1101-2020_06_17_156679	87	39	peaks	peak	NNS
10_1101-2020_06_17_156679	87	40	in	in	IN
10_1101-2020_06_17_156679	87	41	STD	STD	NNP
10_1101-2020_06_17_156679	87	42	173	173	CD
10_1101-2020_06_17_156679	87	43	with	with	IN
10_1101-2020_06_17_156679	87	44	absorptive	absorptive	JJ
10_1101-2020_06_17_156679	87	45	1H	1h	JJ
10_1101-2020_06_17_156679	87	46	lineshapes	lineshape	NNS
10_1101-2020_06_17_156679	87	47	.	.	.
10_1101-2020_06_17_156679	88	1	We	-PRON-	PRP
10_1101-2020_06_17_156679	88	2	surmised	surmise	VBD
10_1101-2020_06_17_156679	88	3	that	that	IN
10_1101-2020_06_17_156679	88	4	STD	STD	NNP
10_1101-2020_06_17_156679	88	5	-	-	HYPH
10_1101-2020_06_17_156679	88	6	NMR	NMR	NNP
10_1101-2020_06_17_156679	88	7	is	be	VBZ
10_1101-2020_06_17_156679	88	8	suitable	suitable	JJ
10_1101-2020_06_17_156679	88	9	for	for	IN
10_1101-2020_06_17_156679	88	10	screening	screen	VBG
10_1101-2020_06_17_156679	88	11	ligand	ligand	NN
10_1101-2020_06_17_156679	88	12	binding	bind	VBG
10_1101-2020_06_17_156679	88	13	to	to	IN
10_1101-2020_06_17_156679	88	14	174	174	CD
10_1101-2020_06_17_156679	88	15	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	88	16	,	,	,
10_1101-2020_06_17_156679	88	17	requiring	require	VBG
10_1101-2020_06_17_156679	88	18	relatively	relatively	RB
10_1101-2020_06_17_156679	88	19	small	small	JJ
10_1101-2020_06_17_156679	88	20	amounts	amount	NNS
10_1101-2020_06_17_156679	88	21	(	(	-LRB-
10_1101-2020_06_17_156679	88	22	10	10	CD
10_1101-2020_06_17_156679	88	23	-	-	SYM
10_1101-2020_06_17_156679	88	24	50	50	CD
10_1101-2020_06_17_156679	88	25	μgr	μgr	NN
10_1101-2020_06_17_156679	88	26	)	)	-RRB-
10_1101-2020_06_17_156679	88	27	of	of	IN
10_1101-2020_06_17_156679	88	28	protein	protein	NN
10_1101-2020_06_17_156679	88	29	and	and	CC
10_1101-2020_06_17_156679	88	30	time	time	NN
10_1101-2020_06_17_156679	88	31	(	(	-LRB-
10_1101-2020_06_17_156679	88	32	under	under	IN
10_1101-2020_06_17_156679	88	33	1	1	CD
10_1101-2020_06_17_156679	88	34	hour	hour	NN
10_1101-2020_06_17_156679	88	35	)	)	-RRB-
10_1101-2020_06_17_156679	88	36	per	per	IN
10_1101-2020_06_17_156679	88	37	sample	sample	NN
10_1101-2020_06_17_156679	88	38	175	175	CD
10_1101-2020_06_17_156679	88	39	studied	study	VBD
10_1101-2020_06_17_156679	88	40	.	.	.
10_1101-2020_06_17_156679	89	1	176	176	CD
10_1101-2020_06_17_156679	89	2	The	the	DT
10_1101-2020_06_17_156679	89	3	strength	strength	NN
10_1101-2020_06_17_156679	89	4	of	of	IN
10_1101-2020_06_17_156679	89	5	STD	STD	NNP
10_1101-2020_06_17_156679	89	6	signal	signal	NN
10_1101-2020_06_17_156679	89	7	is	be	VBZ
10_1101-2020_06_17_156679	89	8	quantified	quantify	VBN
10_1101-2020_06_17_156679	89	9	by	by	IN
10_1101-2020_06_17_156679	89	10	calculating	calculate	VBG
10_1101-2020_06_17_156679	89	11	the	the	DT
10_1101-2020_06_17_156679	89	12	ratio	ratio	NN
10_1101-2020_06_17_156679	89	13	of	of	IN
10_1101-2020_06_17_156679	89	14	integrated	integrate	VBN
10_1101-2020_06_17_156679	89	15	signal	signal	NN
10_1101-2020_06_17_156679	89	16	intensity	intensity	NN
10_1101-2020_06_17_156679	89	17	of	of	IN
10_1101-2020_06_17_156679	89	18	177	177	CD
10_1101-2020_06_17_156679	89	19	peaks	peak	NNS
10_1101-2020_06_17_156679	89	20	in	in	IN
10_1101-2020_06_17_156679	89	21	the	the	DT
10_1101-2020_06_17_156679	89	22	STD	STD	NNP
10_1101-2020_06_17_156679	89	23	spectrum	spectrum	NN
10_1101-2020_06_17_156679	89	24	over	over	IN
10_1101-2020_06_17_156679	89	25	that	that	DT
10_1101-2020_06_17_156679	89	26	of	of	IN
10_1101-2020_06_17_156679	89	27	the	the	DT
10_1101-2020_06_17_156679	89	28	reference	reference	NN
10_1101-2020_06_17_156679	89	29	spectrum	spectrum	NN
10_1101-2020_06_17_156679	89	30	(	(	-LRB-
10_1101-2020_06_17_156679	89	31	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	89	32	)	)	-RRB-
10_1101-2020_06_17_156679	89	33	.	.	.
10_1101-2020_06_17_156679	90	1	The	the	DT
10_1101-2020_06_17_156679	90	2	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	90	3	factor	factor	NN
10_1101-2020_06_17_156679	90	4	is	be	VBZ
10_1101-2020_06_17_156679	90	5	178	178	CD
10_1101-2020_06_17_156679	90	6	inversely	inversely	RB
10_1101-2020_06_17_156679	90	7	proportional	proportional	JJ
10_1101-2020_06_17_156679	90	8	to	to	TO
10_1101-2020_06_17_156679	90	9	ligand	ligand	VB
10_1101-2020_06_17_156679	90	10	Kd	Kd	NNP
10_1101-2020_06_17_156679	90	11	,	,	,
10_1101-2020_06_17_156679	90	12	as	as	IN
10_1101-2020_06_17_156679	90	13	�	�	NNP
10_1101-2020_06_17_156679	90	14	�	�	,
10_1101-2020_06_17_156679	90	15	�	�	NNS
10_1101-2020_06_17_156679	90	16	�	�	VBZ
10_1101-2020_06_17_156679	90	17	�	�	VBZ
10_1101-2020_06_17_156679	90	18	�	�	VBZ
10_1101-2020_06_17_156679	90	19	�	�	VBZ
10_1101-2020_06_17_156679	90	20	�	�	VBZ
10_1101-2020_06_17_156679	90	21	�	�	VBZ
10_1101-2020_06_17_156679	90	22	�	�	VBZ
10_1101-2020_06_17_156679	90	23	�	�	VBZ
10_1101-2020_06_17_156679	90	24	�	�	VBZ
10_1101-2020_06_17_156679	90	25	�	�	NNP
10_1101-2020_06_17_156679	90	26	�	�	NNP
10_1101-2020_06_17_156679	90	27	where	where	WRB
10_1101-2020_06_17_156679	90	28	[	[	-LRB-
10_1101-2020_06_17_156679	90	29	L	l	NN
10_1101-2020_06_17_156679	90	30	]	]	-RRB-
10_1101-2020_06_17_156679	90	31	is	be	VBZ
10_1101-2020_06_17_156679	90	32	ligand	ligand	NNP
10_1101-2020_06_17_156679	90	33	concentration	concentration	NN
10_1101-2020_06_17_156679	90	34	.	.	.
10_1101-2020_06_17_156679	91	1	179	179	CD
10_1101-2020_06_17_156679	91	2	Measuring	measure	VBG
10_1101-2020_06_17_156679	91	3	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	91	4	values	value	NNS
10_1101-2020_06_17_156679	91	5	over	over	IN
10_1101-2020_06_17_156679	91	6	a	a	DT
10_1101-2020_06_17_156679	91	7	range	range	NN
10_1101-2020_06_17_156679	91	8	of	of	IN
10_1101-2020_06_17_156679	91	9	ligand	ligand	NN
10_1101-2020_06_17_156679	91	10	concentrations	concentration	NNS
10_1101-2020_06_17_156679	91	11	allows	allow	VBZ
10_1101-2020_06_17_156679	91	12	fitting	fitting	NN
10_1101-2020_06_17_156679	91	13	of	of	IN
10_1101-2020_06_17_156679	91	14	the	the	DT
10_1101-2020_06_17_156679	91	15	proportionality	proportionality	NN
10_1101-2020_06_17_156679	91	16	180	180	CD
10_1101-2020_06_17_156679	91	17	constant	constant	JJ
10_1101-2020_06_17_156679	91	18	and	and	CC
10_1101-2020_06_17_156679	91	19	calculation	calculation	NN
10_1101-2020_06_17_156679	91	20	of	of	IN
10_1101-2020_06_17_156679	91	21	ligand	ligand	NNP
10_1101-2020_06_17_156679	91	22	Kd	Kd	NNP
10_1101-2020_06_17_156679	91	23	.	.	.
10_1101-2020_06_17_156679	92	1	However	however	RB
10_1101-2020_06_17_156679	92	2	,	,	,
10_1101-2020_06_17_156679	92	3	time	time	NN
10_1101-2020_06_17_156679	92	4	and	and	CC
10_1101-2020_06_17_156679	92	5	sample	sample	NN
10_1101-2020_06_17_156679	92	6	-	-	HYPH
10_1101-2020_06_17_156679	92	7	amount	amount	NN
10_1101-2020_06_17_156679	92	8	considerations	consideration	NNS
10_1101-2020_06_17_156679	92	9	,	,	,
10_1101-2020_06_17_156679	92	10	including	include	VBG
10_1101-2020_06_17_156679	92	11	181	181	CD
10_1101-2020_06_17_156679	92	12	the	the	DT
10_1101-2020_06_17_156679	92	13	limited	limited	JJ
10_1101-2020_06_17_156679	92	14	availability	availability	NN
10_1101-2020_06_17_156679	92	15	of	of	IN
10_1101-2020_06_17_156679	92	16	bespoke	bespoke	NN
10_1101-2020_06_17_156679	92	17	compounds	compound	NNS
10_1101-2020_06_17_156679	92	18	synthesized	synthesize	VBN
10_1101-2020_06_17_156679	92	19	for	for	IN
10_1101-2020_06_17_156679	92	20	the	the	DT
10_1101-2020_06_17_156679	92	21	COVID	COVID	NNP
10_1101-2020_06_17_156679	92	22	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	92	23	project	project	NN
10_1101-2020_06_17_156679	92	24	,	,	,
10_1101-2020_06_17_156679	92	25	made	make	VBD
10_1101-2020_06_17_156679	92	26	182	182	CD
10_1101-2020_06_17_156679	92	27	recording	record	VBG
10_1101-2020_06_17_156679	92	28	full	full	JJ
10_1101-2020_06_17_156679	92	29	STD	STD	NNP
10_1101-2020_06_17_156679	92	30	-	-	HYPH
10_1101-2020_06_17_156679	92	31	NMR	NMR	NNP
10_1101-2020_06_17_156679	92	32	titrations	titration	NNS
10_1101-2020_06_17_156679	92	33	impractical	impractical	JJ
10_1101-2020_06_17_156679	92	34	for	for	IN
10_1101-2020_06_17_156679	92	35	screening	screen	VBG
10_1101-2020_06_17_156679	92	36	hundreds	hundred	NNS
10_1101-2020_06_17_156679	92	37	of	of	IN
10_1101-2020_06_17_156679	92	38	ligands	ligand	NNS
10_1101-2020_06_17_156679	92	39	.	.	.
10_1101-2020_06_17_156679	93	1	Thus	thus	RB
10_1101-2020_06_17_156679	93	2	,	,	,
10_1101-2020_06_17_156679	93	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	93	4	evaluated	evaluate	VBD
10_1101-2020_06_17_156679	93	5	183	183	CD
10_1101-2020_06_17_156679	93	6	whether	whether	IN
10_1101-2020_06_17_156679	93	7	measuring	measure	VBG
10_1101-2020_06_17_156679	93	8	the	the	DT
10_1101-2020_06_17_156679	93	9	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	93	10	value	value	NN
10_1101-2020_06_17_156679	93	11	at	at	IN
10_1101-2020_06_17_156679	93	12	a	a	DT
10_1101-2020_06_17_156679	93	13	single	single	JJ
10_1101-2020_06_17_156679	93	14	ligand	ligand	NN
10_1101-2020_06_17_156679	93	15	concentration	concentration	NN
10_1101-2020_06_17_156679	93	16	may	may	MD
10_1101-2020_06_17_156679	93	17	be	be	VB
10_1101-2020_06_17_156679	93	18	an	an	DT
10_1101-2020_06_17_156679	93	19	informative	informative	JJ
10_1101-2020_06_17_156679	93	20	184	184	CD
10_1101-2020_06_17_156679	93	21	alternative	alternative	NN
10_1101-2020_06_17_156679	93	22	to	to	IN
10_1101-2020_06_17_156679	93	23	Kd	Kd	NNP
10_1101-2020_06_17_156679	93	24	,	,	,
10_1101-2020_06_17_156679	93	25	provided	provide	VBN
10_1101-2020_06_17_156679	93	26	restraints	restraint	NNS
10_1101-2020_06_17_156679	93	27	could	could	MD
10_1101-2020_06_17_156679	93	28	be	be	VB
10_1101-2020_06_17_156679	93	29	placed	place	VBN
10_1101-2020_06_17_156679	93	30	,	,	,
10_1101-2020_06_17_156679	93	31	for	for	IN
10_1101-2020_06_17_156679	93	32	example	example	NN
10_1101-2020_06_17_156679	93	33	,	,	,
10_1101-2020_06_17_156679	93	34	on	on	IN
10_1101-2020_06_17_156679	93	35	the	the	DT
10_1101-2020_06_17_156679	93	36	proportionality	proportionality	NN
10_1101-2020_06_17_156679	93	37	constant	constant	JJ
10_1101-2020_06_17_156679	93	38	.	.	.
10_1101-2020_06_17_156679	94	1	185	185	CD
10_1101-2020_06_17_156679	94	2	Theoretical	theoretical	JJ
10_1101-2020_06_17_156679	94	3	and	and	CC
10_1101-2020_06_17_156679	94	4	practical	practical	JJ
10_1101-2020_06_17_156679	94	5	considerations	consideration	NNS
10_1101-2020_06_17_156679	94	6	suggested	suggest	VBD
10_1101-2020_06_17_156679	94	7	that	that	IN
10_1101-2020_06_17_156679	94	8	three	three	CD
10_1101-2020_06_17_156679	94	9	parameters	parameter	NNS
10_1101-2020_06_17_156679	94	10	influence	influence	VBP
10_1101-2020_06_17_156679	94	11	our	-PRON-	PRP$
10_1101-2020_06_17_156679	94	12	186	186	CD
10_1101-2020_06_17_156679	94	13	evaluation	evaluation	NN
10_1101-2020_06_17_156679	94	14	of	of	IN
10_1101-2020_06_17_156679	94	15	single	single	JJ
10_1101-2020_06_17_156679	94	16	-	-	HYPH
10_1101-2020_06_17_156679	94	17	concentration	concentration	NN
10_1101-2020_06_17_156679	94	18	STDratio	stdratio	NN
10_1101-2020_06_17_156679	94	19	values	value	NNS
10_1101-2020_06_17_156679	94	20	towards	towards	IN
10_1101-2020_06_17_156679	94	21	an	an	DT
10_1101-2020_06_17_156679	94	22	affinity	affinity	NN
10_1101-2020_06_17_156679	94	23	context	context	NN
10_1101-2020_06_17_156679	94	24	.	.	.
10_1101-2020_06_17_156679	95	1	Firstly	firstly	RB
10_1101-2020_06_17_156679	95	2	,	,	,
10_1101-2020_06_17_156679	95	3	the	the	DT
10_1101-2020_06_17_156679	95	4	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	95	5	187	187	CD
10_1101-2020_06_17_156679	95	6	factor	factor	NN
10_1101-2020_06_17_156679	95	7	is	be	VBZ
10_1101-2020_06_17_156679	95	8	affected	affect	VBN
10_1101-2020_06_17_156679	95	9	by	by	IN
10_1101-2020_06_17_156679	95	10	the	the	DT
10_1101-2020_06_17_156679	95	11	efficiency	efficiency	NN
10_1101-2020_06_17_156679	95	12	of	of	IN
10_1101-2020_06_17_156679	95	13	NOE	NOE	NNP
10_1101-2020_06_17_156679	95	14	magnetisation	magnetisation	NN
10_1101-2020_06_17_156679	95	15	transfer	transfer	NN
10_1101-2020_06_17_156679	95	16	between	between	IN
10_1101-2020_06_17_156679	95	17	protein	protein	NN
10_1101-2020_06_17_156679	95	18	and	and	CC
10_1101-2020_06_17_156679	95	19	ligand	ligand	NNP
10_1101-2020_06_17_156679	95	20	,	,	,
10_1101-2020_06_17_156679	95	21	which	which	WDT
10_1101-2020_06_17_156679	95	22	188	188	CD
10_1101-2020_06_17_156679	95	23	in	in	IN
10_1101-2020_06_17_156679	95	24	turn	turn	NN
10_1101-2020_06_17_156679	95	25	depends	depend	VBZ
10_1101-2020_06_17_156679	95	26	on	on	IN
10_1101-2020_06_17_156679	95	27	the	the	DT
10_1101-2020_06_17_156679	95	28	proximity	proximity	NN
10_1101-2020_06_17_156679	95	29	of	of	IN
10_1101-2020_06_17_156679	95	30	ligand	ligand	NN
10_1101-2020_06_17_156679	95	31	and	and	CC
10_1101-2020_06_17_156679	95	32	protein	protein	NN
10_1101-2020_06_17_156679	95	33	groups	group	NNS
10_1101-2020_06_17_156679	95	34	,	,	,
10_1101-2020_06_17_156679	95	35	and	and	CC
10_1101-2020_06_17_156679	95	36	the	the	DT
10_1101-2020_06_17_156679	95	37	chemical	chemical	NN
10_1101-2020_06_17_156679	95	38	nature	nature	NN
10_1101-2020_06_17_156679	95	39	of	of	IN
10_1101-2020_06_17_156679	95	40	these	these	DT
10_1101-2020_06_17_156679	95	41	189	189	CD
10_1101-2020_06_17_156679	95	42	.CC	.CC	NFP
10_1101-2020_06_17_156679	95	43	-	-	:
10_1101-2020_06_17_156679	95	44	BY	by	IN
10_1101-2020_06_17_156679	95	45	4.0	4.0	CD
10_1101-2020_06_17_156679	95	46	International	International	NNP
10_1101-2020_06_17_156679	95	47	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	95	48	under	under	IN
10_1101-2020_06_17_156679	95	49	a	a	DT
10_1101-2020_06_17_156679	95	50	(	(	-LRB-
10_1101-2020_06_17_156679	95	51	which	which	WDT
10_1101-2020_06_17_156679	95	52	was	be	VBD
10_1101-2020_06_17_156679	95	53	not	not	RB
10_1101-2020_06_17_156679	95	54	certified	certify	VBN
10_1101-2020_06_17_156679	95	55	by	by	IN
10_1101-2020_06_17_156679	95	56	peer	peer	NN
10_1101-2020_06_17_156679	95	57	review	review	NN
10_1101-2020_06_17_156679	95	58	)	)	-RRB-
10_1101-2020_06_17_156679	95	59	is	be	VBZ
10_1101-2020_06_17_156679	95	60	the	the	DT
10_1101-2020_06_17_156679	95	61	author	author	NN
10_1101-2020_06_17_156679	95	62	/	/	SYM
10_1101-2020_06_17_156679	95	63	funder	funder	NN
10_1101-2020_06_17_156679	95	64	,	,	,
10_1101-2020_06_17_156679	95	65	who	who	WP
10_1101-2020_06_17_156679	95	66	has	have	VBZ
10_1101-2020_06_17_156679	95	67	granted	grant	VBN
10_1101-2020_06_17_156679	95	68	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	95	69	a	a	DT
10_1101-2020_06_17_156679	95	70	license	license	NN
10_1101-2020_06_17_156679	95	71	to	to	TO
10_1101-2020_06_17_156679	95	72	display	display	VB
10_1101-2020_06_17_156679	95	73	the	the	DT
10_1101-2020_06_17_156679	95	74	preprint	preprint	NN
10_1101-2020_06_17_156679	95	75	in	in	IN
10_1101-2020_06_17_156679	95	76	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	95	77	.	.	.
10_1101-2020_06_17_156679	96	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	96	2	is	be	VBZ
10_1101-2020_06_17_156679	96	3	made	make	VBN
10_1101-2020_06_17_156679	96	4	The	the	DT
10_1101-2020_06_17_156679	96	5	copyright	copyright	NN
10_1101-2020_06_17_156679	96	6	holder	holder	NN
10_1101-2020_06_17_156679	96	7	for	for	IN
10_1101-2020_06_17_156679	96	8	this	this	DT
10_1101-2020_06_17_156679	96	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	96	10	version	version	NN
10_1101-2020_06_17_156679	96	11	posted	post	VBD
10_1101-2020_06_17_156679	96	12	January	January	NNP
10_1101-2020_06_17_156679	96	13	6	6	CD
10_1101-2020_06_17_156679	96	14	,	,	,
10_1101-2020_06_17_156679	96	15	2021	2021	CD
10_1101-2020_06_17_156679	96	16	.	.	.
10_1101-2020_06_17_156679	96	17	;	;	:
10_1101-2020_06_17_156679	96	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	96	19	:	:	:
10_1101-2020_06_17_156679	96	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	96	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	96	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	96	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	96	24	8	8	CD
10_1101-2020_06_17_156679	96	25	groups	group	NNS
10_1101-2020_06_17_156679	96	26	(	(	-LRB-
10_1101-2020_06_17_156679	96	27	20	20	CD
10_1101-2020_06_17_156679	96	28	-	-	SYM
10_1101-2020_06_17_156679	96	29	22	22	CD
10_1101-2020_06_17_156679	96	30	)	)	-RRB-
10_1101-2020_06_17_156679	96	31	.	.	.
10_1101-2020_06_17_156679	97	1	To	to	TO
10_1101-2020_06_17_156679	97	2	minimize	minimize	VB
10_1101-2020_06_17_156679	97	3	the	the	DT
10_1101-2020_06_17_156679	97	4	influence	influence	NN
10_1101-2020_06_17_156679	97	5	of	of	IN
10_1101-2020_06_17_156679	97	6	these	these	DT
10_1101-2020_06_17_156679	97	7	factors	factor	NNS
10_1101-2020_06_17_156679	97	8	across	across	IN
10_1101-2020_06_17_156679	97	9	diverse	diverse	JJ
10_1101-2020_06_17_156679	97	10	ligands	ligand	NNS
10_1101-2020_06_17_156679	97	11	,	,	,
10_1101-2020_06_17_156679	97	12	we	-PRON-	PRP
10_1101-2020_06_17_156679	97	13	sought	seek	VBD
10_1101-2020_06_17_156679	97	14	to	to	IN
10_1101-2020_06_17_156679	97	15	190	190	CD
10_1101-2020_06_17_156679	97	16	quantify	quantify	VB
10_1101-2020_06_17_156679	97	17	the	the	DT
10_1101-2020_06_17_156679	97	18	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	97	19	of	of	IN
10_1101-2020_06_17_156679	97	20	only	only	JJ
10_1101-2020_06_17_156679	97	21	aromatic	aromatic	JJ
10_1101-2020_06_17_156679	97	22	ligand	ligand	NN
10_1101-2020_06_17_156679	97	23	groups	group	NNS
10_1101-2020_06_17_156679	97	24	,	,	,
10_1101-2020_06_17_156679	97	25	and	and	CC
10_1101-2020_06_17_156679	97	26	only	only	RB
10_1101-2020_06_17_156679	97	27	consider	consider	VB
10_1101-2020_06_17_156679	97	28	those	those	DT
10_1101-2020_06_17_156679	97	29	showing	show	VBG
10_1101-2020_06_17_156679	97	30	the	the	DT
10_1101-2020_06_17_156679	97	31	strongest	strong	JJS
10_1101-2020_06_17_156679	97	32	191	191	CD
10_1101-2020_06_17_156679	97	33	STD	std	NN
10_1101-2020_06_17_156679	97	34	signal	signal	NN
10_1101-2020_06_17_156679	97	35	;	;	:
10_1101-2020_06_17_156679	97	36	thus	thus	RB
10_1101-2020_06_17_156679	97	37	,	,	,
10_1101-2020_06_17_156679	97	38	that	that	WDT
10_1101-2020_06_17_156679	97	39	are	be	VBP
10_1101-2020_06_17_156679	97	40	in	in	IN
10_1101-2020_06_17_156679	97	41	closest	close	JJS
10_1101-2020_06_17_156679	97	42	proximity	proximity	NN
10_1101-2020_06_17_156679	97	43	to	to	IN
10_1101-2020_06_17_156679	97	44	the	the	DT
10_1101-2020_06_17_156679	97	45	protein	protein	NN
10_1101-2020_06_17_156679	97	46	.	.	.
10_1101-2020_06_17_156679	98	1	Second	second	JJ
10_1101-2020_06_17_156679	98	2	,	,	,
10_1101-2020_06_17_156679	98	3	STD	STD	NNP
10_1101-2020_06_17_156679	98	4	-	-	HYPH
10_1101-2020_06_17_156679	98	5	NMR	NMR	NNP
10_1101-2020_06_17_156679	98	6	assays	assays	RB
10_1101-2020_06_17_156679	98	7	require	require	VBP
10_1101-2020_06_17_156679	98	8	ligand	ligand	NNP
10_1101-2020_06_17_156679	98	9	192	192	CD
10_1101-2020_06_17_156679	98	10	exchange	exchange	NN
10_1101-2020_06_17_156679	98	11	between	between	IN
10_1101-2020_06_17_156679	98	12	protein	protein	NN
10_1101-2020_06_17_156679	98	13	-	-	HYPH
10_1101-2020_06_17_156679	98	14	bound	bind	VBN
10_1101-2020_06_17_156679	98	15	and	and	CC
10_1101-2020_06_17_156679	98	16	-free	-free	JJ
10_1101-2020_06_17_156679	98	17	states	state	NNS
10_1101-2020_06_17_156679	98	18	in	in	IN
10_1101-2020_06_17_156679	98	19	the	the	DT
10_1101-2020_06_17_156679	98	20	timeframe	timeframe	NN
10_1101-2020_06_17_156679	98	21	of	of	IN
10_1101-2020_06_17_156679	98	22	the	the	DT
10_1101-2020_06_17_156679	98	23	experiment	experiment	NN
10_1101-2020_06_17_156679	98	24	;	;	:
10_1101-2020_06_17_156679	98	25	strongly	strongly	RB
10_1101-2020_06_17_156679	98	26	193	193	CD
10_1101-2020_06_17_156679	98	27	bound	bind	VBD
10_1101-2020_06_17_156679	98	28	compounds	compound	NNS
10_1101-2020_06_17_156679	98	29	that	that	WDT
10_1101-2020_06_17_156679	98	30	dissociate	dissociate	VBP
10_1101-2020_06_17_156679	98	31	very	very	RB
10_1101-2020_06_17_156679	98	32	slowly	slowly	RB
10_1101-2020_06_17_156679	98	33	from	from	IN
10_1101-2020_06_17_156679	98	34	the	the	DT
10_1101-2020_06_17_156679	98	35	protein	protein	NN
10_1101-2020_06_17_156679	98	36	would	would	MD
10_1101-2020_06_17_156679	98	37	yield	yield	VB
10_1101-2020_06_17_156679	98	38	reduced	reduced	JJ
10_1101-2020_06_17_156679	98	39	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	98	40	values	value	NNS
10_1101-2020_06_17_156679	98	41	194	194	CD
10_1101-2020_06_17_156679	98	42	compared	compare	VBN
10_1101-2020_06_17_156679	98	43	to	to	IN
10_1101-2020_06_17_156679	98	44	weaker	weak	JJR
10_1101-2020_06_17_156679	98	45	ligands	ligand	NNS
10_1101-2020_06_17_156679	98	46	that	that	WDT
10_1101-2020_06_17_156679	98	47	dissociate	dissociate	VBP
10_1101-2020_06_17_156679	98	48	more	more	RBR
10_1101-2020_06_17_156679	98	49	readily	readily	RB
10_1101-2020_06_17_156679	98	50	.	.	.
10_1101-2020_06_17_156679	99	1	Structures	structure	NNS
10_1101-2020_06_17_156679	99	2	of	of	IN
10_1101-2020_06_17_156679	99	3	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	99	4	with	with	IN
10_1101-2020_06_17_156679	99	5	many	many	JJ
10_1101-2020_06_17_156679	99	6	different	different	JJ
10_1101-2020_06_17_156679	99	7	195	195	CD
10_1101-2020_06_17_156679	99	8	ligands	ligand	NNS
10_1101-2020_06_17_156679	99	9	show	show	VBP
10_1101-2020_06_17_156679	99	10	that	that	IN
10_1101-2020_06_17_156679	99	11	the	the	DT
10_1101-2020_06_17_156679	99	12	protein	protein	NN
10_1101-2020_06_17_156679	99	13	conformation	conformation	NN
10_1101-2020_06_17_156679	99	14	does	do	VBZ
10_1101-2020_06_17_156679	99	15	not	not	RB
10_1101-2020_06_17_156679	99	16	change	change	VB
10_1101-2020_06_17_156679	99	17	upon	upon	IN
10_1101-2020_06_17_156679	99	18	complex	complex	JJ
10_1101-2020_06_17_156679	99	19	formation	formation	NN
10_1101-2020_06_17_156679	99	20	and	and	CC
10_1101-2020_06_17_156679	99	21	that	that	IN
10_1101-2020_06_17_156679	99	22	the	the	DT
10_1101-2020_06_17_156679	99	23	196	196	CD
10_1101-2020_06_17_156679	99	24	active	active	JJ
10_1101-2020_06_17_156679	99	25	site	site	NN
10_1101-2020_06_17_156679	99	26	is	be	VBZ
10_1101-2020_06_17_156679	99	27	fully	fully	RB
10_1101-2020_06_17_156679	99	28	solvent	solvent	VBN
10_1101-2020_06_17_156679	99	29	-	-	HYPH
10_1101-2020_06_17_156679	99	30	exposed	expose	VBN
10_1101-2020_06_17_156679	99	31	(	(	-LRB-
10_1101-2020_06_17_156679	99	32	18	18	CD
10_1101-2020_06_17_156679	99	33	)	)	-RRB-
10_1101-2020_06_17_156679	99	34	,	,	,
10_1101-2020_06_17_156679	99	35	which	which	WDT
10_1101-2020_06_17_156679	99	36	suggests	suggest	VBZ
10_1101-2020_06_17_156679	99	37	that	that	IN
10_1101-2020_06_17_156679	99	38	ligand	ligand	NNP
10_1101-2020_06_17_156679	99	39	association	association	NNP
10_1101-2020_06_17_156679	99	40	can	can	MD
10_1101-2020_06_17_156679	99	41	proceed	proceed	VB
10_1101-2020_06_17_156679	99	42	with	with	IN
10_1101-2020_06_17_156679	99	43	high	high	JJ
10_1101-2020_06_17_156679	99	44	197	197	CD
10_1101-2020_06_17_156679	99	45	rate	rate	NN
10_1101-2020_06_17_156679	99	46	(	(	-LRB-
10_1101-2020_06_17_156679	99	47	107	107	CD
10_1101-2020_06_17_156679	99	48	–	–	:
10_1101-2020_06_17_156679	99	49	108	108	CD
10_1101-2020_06_17_156679	99	50	M-1s-1	m-1s-1	NN
10_1101-2020_06_17_156679	99	51	)	)	-RRB-
10_1101-2020_06_17_156679	99	52	.	.	.
10_1101-2020_06_17_156679	100	1	Under	under	IN
10_1101-2020_06_17_156679	100	2	this	this	DT
10_1101-2020_06_17_156679	100	3	assumption	assumption	NN
10_1101-2020_06_17_156679	100	4	,	,	,
10_1101-2020_06_17_156679	100	5	the	the	DT
10_1101-2020_06_17_156679	100	6	ligand	ligand	NN
10_1101-2020_06_17_156679	100	7	dissociation	dissociation	NN
10_1101-2020_06_17_156679	100	8	rate	rate	NN
10_1101-2020_06_17_156679	100	9	is	be	VBZ
10_1101-2020_06_17_156679	100	10	the	the	DT
10_1101-2020_06_17_156679	100	11	primary	primary	JJ
10_1101-2020_06_17_156679	100	12	determinant	determinant	NN
10_1101-2020_06_17_156679	100	13	198	198	CD
10_1101-2020_06_17_156679	100	14	of	of	IN
10_1101-2020_06_17_156679	100	15	interaction	interaction	NN
10_1101-2020_06_17_156679	100	16	strength	strength	NN
10_1101-2020_06_17_156679	100	17	.	.	.
10_1101-2020_06_17_156679	101	1	Given	give	VBN
10_1101-2020_06_17_156679	101	2	the	the	DT
10_1101-2020_06_17_156679	101	3	duration	duration	NN
10_1101-2020_06_17_156679	101	4	of	of	IN
10_1101-2020_06_17_156679	101	5	the	the	DT
10_1101-2020_06_17_156679	101	6	STD	STD	NNP
10_1101-2020_06_17_156679	101	7	-	-	HYPH
10_1101-2020_06_17_156679	101	8	NMR	NMR	NNP
10_1101-2020_06_17_156679	101	9	experiment	experiment	NN
10_1101-2020_06_17_156679	101	10	in	in	IN
10_1101-2020_06_17_156679	101	11	our	-PRON-	PRP$
10_1101-2020_06_17_156679	101	12	assays	assay	NNS
10_1101-2020_06_17_156679	101	13	,	,	,
10_1101-2020_06_17_156679	101	14	and	and	CC
10_1101-2020_06_17_156679	101	15	the	the	DT
10_1101-2020_06_17_156679	101	16	ratios	ratio	NNS
10_1101-2020_06_17_156679	101	17	199	199	CD
10_1101-2020_06_17_156679	101	18	of	of	IN
10_1101-2020_06_17_156679	101	19	ligand	ligand	NNP
10_1101-2020_06_17_156679	101	20	:	:	:
10_1101-2020_06_17_156679	101	21	protein	protein	NNP
10_1101-2020_06_17_156679	101	22	used	use	VBD
10_1101-2020_06_17_156679	101	23	,	,	,
10_1101-2020_06_17_156679	101	24	we	-PRON-	PRP
10_1101-2020_06_17_156679	101	25	estimated	estimate	VBD
10_1101-2020_06_17_156679	101	26	that	that	IN
10_1101-2020_06_17_156679	101	27	significant	significant	JJ
10_1101-2020_06_17_156679	101	28	protein	protein	NN
10_1101-2020_06_17_156679	101	29	–	–	:
10_1101-2020_06_17_156679	101	30	ligand	ligand	NNP
10_1101-2020_06_17_156679	101	31	exchange	exchange	NNP
10_1101-2020_06_17_156679	101	32	will	will	MD
10_1101-2020_06_17_156679	101	33	take	take	VB
10_1101-2020_06_17_156679	101	34	place	place	NN
10_1101-2020_06_17_156679	101	35	even	even	RB
10_1101-2020_06_17_156679	101	36	200	200	CD
10_1101-2020_06_17_156679	101	37	for	for	IN
10_1101-2020_06_17_156679	101	38	interactions	interaction	NNS
10_1101-2020_06_17_156679	101	39	as	as	RB
10_1101-2020_06_17_156679	101	40	strong	strong	JJ
10_1101-2020_06_17_156679	101	41	as	as	IN
10_1101-2020_06_17_156679	101	42	low	low	JJ
10_1101-2020_06_17_156679	101	43	-	-	HYPH
10_1101-2020_06_17_156679	101	44	μM	μm	NN
10_1101-2020_06_17_156679	101	45	Kd	Kd	NNP
10_1101-2020_06_17_156679	101	46	.	.	.
10_1101-2020_06_17_156679	102	1	Finally	finally	RB
10_1101-2020_06_17_156679	102	2	,	,	,
10_1101-2020_06_17_156679	102	3	uncertainties	uncertainty	NNS
10_1101-2020_06_17_156679	102	4	or	or	CC
10_1101-2020_06_17_156679	102	5	errors	error	NNS
10_1101-2020_06_17_156679	102	6	in	in	IN
10_1101-2020_06_17_156679	102	7	nominal	nominal	JJ
10_1101-2020_06_17_156679	102	8	ligand	ligand	NNP
10_1101-2020_06_17_156679	102	9	201	201	CD
10_1101-2020_06_17_156679	102	10	concentration	concentration	NN
10_1101-2020_06_17_156679	102	11	skew	skew	VB
10_1101-2020_06_17_156679	102	12	the	the	DT
10_1101-2020_06_17_156679	102	13	correlation	correlation	NN
10_1101-2020_06_17_156679	102	14	of	of	IN
10_1101-2020_06_17_156679	102	15	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	102	16	to	to	TO
10_1101-2020_06_17_156679	102	17	compound	compound	VB
10_1101-2020_06_17_156679	102	18	affinities	affinity	NNS
10_1101-2020_06_17_156679	102	19	;	;	:
10_1101-2020_06_17_156679	102	20	as	as	IN
10_1101-2020_06_17_156679	102	21	shown	show	VBN
10_1101-2020_06_17_156679	102	22	in	in	IN
10_1101-2020_06_17_156679	102	23	Fig	Fig	NNP
10_1101-2020_06_17_156679	102	24	.	.	.
10_1101-2020_06_17_156679	103	1	S1	S1	NNS
10_1101-2020_06_17_156679	103	2	,	,	,
10_1101-2020_06_17_156679	103	3	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	103	4	202	202	CD
10_1101-2020_06_17_156679	103	5	values	value	NNS
10_1101-2020_06_17_156679	103	6	increase	increase	VBP
10_1101-2020_06_17_156679	103	7	strongly	strongly	RB
10_1101-2020_06_17_156679	103	8	when	when	WRB
10_1101-2020_06_17_156679	103	9	very	very	RB
10_1101-2020_06_17_156679	103	10	small	small	JJ
10_1101-2020_06_17_156679	103	11	amounts	amount	NNS
10_1101-2020_06_17_156679	103	12	of	of	IN
10_1101-2020_06_17_156679	103	13	ligands	ligand	NNS
10_1101-2020_06_17_156679	103	14	are	be	VBP
10_1101-2020_06_17_156679	103	15	assessed	assess	VBN
10_1101-2020_06_17_156679	103	16	.	.	.
10_1101-2020_06_17_156679	104	1	Thus	thus	RB
10_1101-2020_06_17_156679	104	2	,	,	,
10_1101-2020_06_17_156679	104	3	overly	overly	RB
10_1101-2020_06_17_156679	104	4	large	large	JJ
10_1101-2020_06_17_156679	104	5	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	104	6	203	203	CD
10_1101-2020_06_17_156679	104	7	values	value	NNS
10_1101-2020_06_17_156679	104	8	may	may	MD
10_1101-2020_06_17_156679	104	9	be	be	VB
10_1101-2020_06_17_156679	104	10	measured	measure	VBN
10_1101-2020_06_17_156679	104	11	if	if	IN
10_1101-2020_06_17_156679	104	12	ligand	ligand	NN
10_1101-2020_06_17_156679	104	13	concentrations	concentration	NNS
10_1101-2020_06_17_156679	104	14	are	be	VBP
10_1101-2020_06_17_156679	104	15	significantly	significantly	RB
10_1101-2020_06_17_156679	104	16	lower	low	JJR
10_1101-2020_06_17_156679	104	17	than	than	IN
10_1101-2020_06_17_156679	104	18	anticipated	anticipate	VBN
10_1101-2020_06_17_156679	104	19	.	.	.
10_1101-2020_06_17_156679	105	1	204	204	CD
10_1101-2020_06_17_156679	105	2	205	205	CD
10_1101-2020_06_17_156679	105	3	Quantitating	Quantitating	NNP
10_1101-2020_06_17_156679	105	4	M	M	NNP
10_1101-2020_06_17_156679	105	5	pro	pro	JJ
10_1101-2020_06_17_156679	105	6	binding	binding	NN
10_1101-2020_06_17_156679	105	7	of	of	IN
10_1101-2020_06_17_156679	105	8	ligands	ligand	NNS
10_1101-2020_06_17_156679	105	9	identified	identify	VBN
10_1101-2020_06_17_156679	105	10	by	by	IN
10_1101-2020_06_17_156679	105	11	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	105	12	screening	screening	NN
10_1101-2020_06_17_156679	105	13	206	206	CD
10_1101-2020_06_17_156679	105	14	Mindful	mindful	JJ
10_1101-2020_06_17_156679	105	15	of	of	IN
10_1101-2020_06_17_156679	105	16	the	the	DT
10_1101-2020_06_17_156679	105	17	limitations	limitation	NNS
10_1101-2020_06_17_156679	105	18	inherent	inherent	JJ
10_1101-2020_06_17_156679	105	19	to	to	IN
10_1101-2020_06_17_156679	105	20	measuring	measure	VBG
10_1101-2020_06_17_156679	105	21	single	single	JJ
10_1101-2020_06_17_156679	105	22	-	-	HYPH
10_1101-2020_06_17_156679	105	23	concentration	concentration	NN
10_1101-2020_06_17_156679	105	24	STDratio	stdratio	NN
10_1101-2020_06_17_156679	105	25	values	value	NNS
10_1101-2020_06_17_156679	105	26	,	,	,
10_1101-2020_06_17_156679	105	27	and	and	CC
10_1101-2020_06_17_156679	105	28	prior	prior	RB
10_1101-2020_06_17_156679	105	29	to	to	IN
10_1101-2020_06_17_156679	105	30	207	207	CD
10_1101-2020_06_17_156679	105	31	using	use	VBG
10_1101-2020_06_17_156679	105	32	STD	STD	NNP
10_1101-2020_06_17_156679	105	33	-	-	HYPH
10_1101-2020_06_17_156679	105	34	NMR	NMR	NNP
10_1101-2020_06_17_156679	105	35	to	to	TO
10_1101-2020_06_17_156679	105	36	evaluate	evaluate	VB
10_1101-2020_06_17_156679	105	37	bespoke	bespoke	NN
10_1101-2020_06_17_156679	105	38	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	105	39	ligands	ligand	NNS
10_1101-2020_06_17_156679	105	40	,	,	,
10_1101-2020_06_17_156679	105	41	we	-PRON-	PRP
10_1101-2020_06_17_156679	105	42	used	use	VBD
10_1101-2020_06_17_156679	105	43	this	this	DT
10_1101-2020_06_17_156679	105	44	method	method	NN
10_1101-2020_06_17_156679	105	45	to	to	TO
10_1101-2020_06_17_156679	105	46	assess	assess	VB
10_1101-2020_06_17_156679	105	47	binding	bind	VBG
10_1101-2020_06_17_156679	105	48	to	to	IN
10_1101-2020_06_17_156679	105	49	the	the	DT
10_1101-2020_06_17_156679	105	50	208	208	CD
10_1101-2020_06_17_156679	105	51	protease	protease	NN
10_1101-2020_06_17_156679	105	52	of	of	IN
10_1101-2020_06_17_156679	105	53	small	small	JJ
10_1101-2020_06_17_156679	105	54	chemical	chemical	NN
10_1101-2020_06_17_156679	105	55	fragments	fragment	NNS
10_1101-2020_06_17_156679	105	56	identified	identify	VBN
10_1101-2020_06_17_156679	105	57	in	in	IN
10_1101-2020_06_17_156679	105	58	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	105	59	screening	screening	NN
10_1101-2020_06_17_156679	105	60	experiments	experiment	NNS
10_1101-2020_06_17_156679	105	61	(	(	-LRB-
10_1101-2020_06_17_156679	105	62	18	18	CD
10_1101-2020_06_17_156679	105	63	)	)	-RRB-
10_1101-2020_06_17_156679	105	64	.	.	.
10_1101-2020_06_17_156679	106	1	In	in	IN
10_1101-2020_06_17_156679	106	2	209	209	CD
10_1101-2020_06_17_156679	106	3	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	106	4	screening	screening	NN
10_1101-2020_06_17_156679	106	5	campaigns	campaign	NNS
10_1101-2020_06_17_156679	106	6	of	of	IN
10_1101-2020_06_17_156679	106	7	other	other	JJ
10_1101-2020_06_17_156679	106	8	target	target	NN
10_1101-2020_06_17_156679	106	9	proteins	protein	NNS
10_1101-2020_06_17_156679	106	10	such	such	JJ
10_1101-2020_06_17_156679	106	11	fragments	fragment	NNS
10_1101-2020_06_17_156679	106	12	were	be	VBD
10_1101-2020_06_17_156679	106	13	seen	see	VBN
10_1101-2020_06_17_156679	106	14	to	to	TO
10_1101-2020_06_17_156679	106	15	have	have	VB
10_1101-2020_06_17_156679	106	16	210	210	CD
10_1101-2020_06_17_156679	106	17	very	very	RB
10_1101-2020_06_17_156679	106	18	weak	weak	JJ
10_1101-2020_06_17_156679	106	19	affinities	affinity	NNS
10_1101-2020_06_17_156679	106	20	(	(	-LRB-
10_1101-2020_06_17_156679	106	21	>	>	XX
10_1101-2020_06_17_156679	106	22	1	1	CD
10_1101-2020_06_17_156679	106	23	mM	mM	NNP
10_1101-2020_06_17_156679	106	24	Kd	Kd	NNP
10_1101-2020_06_17_156679	106	25	,	,	,
10_1101-2020_06_17_156679	106	26	e.g.	e.g.	RB
10_1101-2020_06_17_156679	107	1	(	(	-LRB-
10_1101-2020_06_17_156679	107	2	35	35	CD
10_1101-2020_06_17_156679	107	3	)	)	-RRB-
10_1101-2020_06_17_156679	107	4	)	)	-RRB-
10_1101-2020_06_17_156679	107	5	,	,	,
10_1101-2020_06_17_156679	107	6	thereby	thereby	RB
10_1101-2020_06_17_156679	107	7	satisfying	satisfy	VBG
10_1101-2020_06_17_156679	107	8	the	the	DT
10_1101-2020_06_17_156679	107	9	exchange	exchange	NN
10_1101-2020_06_17_156679	107	10	criterion	criterion	NN
10_1101-2020_06_17_156679	107	11	set	set	VBN
10_1101-2020_06_17_156679	107	12	out	out	RP
10_1101-2020_06_17_156679	107	13	above	above	RB
10_1101-2020_06_17_156679	107	14	.	.	.
10_1101-2020_06_17_156679	108	1	39	39	CD
10_1101-2020_06_17_156679	108	2	211	211	CD
10_1101-2020_06_17_156679	108	3	non	non	JJ
10_1101-2020_06_17_156679	108	4	-	-	JJ
10_1101-2020_06_17_156679	108	5	covalent	covalent	JJ
10_1101-2020_06_17_156679	108	6	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	108	7	interactors	interactor	NNS
10_1101-2020_06_17_156679	108	8	are	be	VBP
10_1101-2020_06_17_156679	108	9	part	part	NN
10_1101-2020_06_17_156679	108	10	of	of	IN
10_1101-2020_06_17_156679	108	11	the	the	DT
10_1101-2020_06_17_156679	108	12	DSI	DSI	NNP
10_1101-2020_06_17_156679	108	13	-	-	HYPH
10_1101-2020_06_17_156679	108	14	poised	poise	VBN
10_1101-2020_06_17_156679	108	15	fragment	fragment	NN
10_1101-2020_06_17_156679	108	16	library	library	NN
10_1101-2020_06_17_156679	108	17	to	to	TO
10_1101-2020_06_17_156679	108	18	which	which	WDT
10_1101-2020_06_17_156679	108	19	we	-PRON-	PRP
10_1101-2020_06_17_156679	108	20	were	be	VBD
10_1101-2020_06_17_156679	108	21	given	give	VBN
10_1101-2020_06_17_156679	108	22	212	212	CD
10_1101-2020_06_17_156679	108	23	access	access	NN
10_1101-2020_06_17_156679	108	24	,	,	,
10_1101-2020_06_17_156679	108	25	comprising	comprise	VBG
10_1101-2020_06_17_156679	108	26	17	17	CD
10_1101-2020_06_17_156679	108	27	active	active	JJ
10_1101-2020_06_17_156679	108	28	site	site	NN
10_1101-2020_06_17_156679	108	29	binders	binder	NNS
10_1101-2020_06_17_156679	108	30	,	,	,
10_1101-2020_06_17_156679	108	31	two	two	CD
10_1101-2020_06_17_156679	108	32	compounds	compound	NNS
10_1101-2020_06_17_156679	108	33	targeting	target	VBG
10_1101-2020_06_17_156679	108	34	the	the	DT
10_1101-2020_06_17_156679	108	35	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	108	36	dimerisation	dimerisation	NN
10_1101-2020_06_17_156679	108	37	interface	interface	NN
10_1101-2020_06_17_156679	108	38	213	213	CD
10_1101-2020_06_17_156679	108	39	and	and	CC
10_1101-2020_06_17_156679	108	40	20	20	CD
10_1101-2020_06_17_156679	108	41	molecules	molecule	NNS
10_1101-2020_06_17_156679	108	42	binding	bind	VBG
10_1101-2020_06_17_156679	108	43	elsewhere	elsewhere	RB
10_1101-2020_06_17_156679	108	44	on	on	IN
10_1101-2020_06_17_156679	108	45	the	the	DT
10_1101-2020_06_17_156679	108	46	protein	protein	NN
10_1101-2020_06_17_156679	108	47	surface	surface	NN
10_1101-2020_06_17_156679	108	48	(	(	-LRB-
10_1101-2020_06_17_156679	108	49	18	18	CD
10_1101-2020_06_17_156679	108	50	)	)	-RRB-
10_1101-2020_06_17_156679	108	51	.	.	.
10_1101-2020_06_17_156679	109	1	We	-PRON-	PRP
10_1101-2020_06_17_156679	109	2	initially	initially	RB
10_1101-2020_06_17_156679	109	3	recorded	record	VBD
10_1101-2020_06_17_156679	109	4	STD	STD	NNP
10_1101-2020_06_17_156679	109	5	-	-	HYPH
10_1101-2020_06_17_156679	109	6	NMR	NMR	NNP
10_1101-2020_06_17_156679	109	7	214	214	CD
10_1101-2020_06_17_156679	109	8	spectra	spectra	NN
10_1101-2020_06_17_156679	109	9	from	from	IN
10_1101-2020_06_17_156679	109	10	these	these	DT
10_1101-2020_06_17_156679	109	11	compounds	compound	NNS
10_1101-2020_06_17_156679	109	12	in	in	IN
10_1101-2020_06_17_156679	109	13	the	the	DT
10_1101-2020_06_17_156679	109	14	absence	absence	NN
10_1101-2020_06_17_156679	109	15	of	of	IN
10_1101-2020_06_17_156679	109	16	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	109	17	to	to	TO
10_1101-2020_06_17_156679	109	18	confirm	confirm	VB
10_1101-2020_06_17_156679	109	19	that	that	IN
10_1101-2020_06_17_156679	109	20	we	-PRON-	PRP
10_1101-2020_06_17_156679	109	21	obtained	obtain	VBD
10_1101-2020_06_17_156679	109	22	no	no	DT
10_1101-2020_06_17_156679	109	23	or	or	CC
10_1101-2020_06_17_156679	109	24	minimal	minimal	JJ
10_1101-2020_06_17_156679	109	25	215	215	CD
10_1101-2020_06_17_156679	109	26	STD	STD	NNP
10_1101-2020_06_17_156679	109	27	signal	signal	NN
10_1101-2020_06_17_156679	109	28	when	when	WRB
10_1101-2020_06_17_156679	109	29	protease	protease	NNP
10_1101-2020_06_17_156679	109	30	is	be	VBZ
10_1101-2020_06_17_156679	109	31	omitted	omit	VBN
10_1101-2020_06_17_156679	109	32	,	,	,
10_1101-2020_06_17_156679	109	33	and	and	CC
10_1101-2020_06_17_156679	109	34	to	to	TO
10_1101-2020_06_17_156679	109	35	verify	verify	VB
10_1101-2020_06_17_156679	109	36	ligand	ligand	NN
10_1101-2020_06_17_156679	109	37	identity	identity	NN
10_1101-2020_06_17_156679	109	38	from	from	IN
10_1101-2020_06_17_156679	109	39	reference	reference	NN
10_1101-2020_06_17_156679	109	40	1H	1H	NNP
10_1101-2020_06_17_156679	109	41	spectra	spectra	NNP
10_1101-2020_06_17_156679	109	42	.	.	.
10_1101-2020_06_17_156679	110	1	Five	five	CD
10_1101-2020_06_17_156679	110	2	216	216	CD
10_1101-2020_06_17_156679	110	3	ligands	ligand	NNS
10_1101-2020_06_17_156679	110	4	gave	give	VBD
10_1101-2020_06_17_156679	110	5	no	no	DT
10_1101-2020_06_17_156679	110	6	solution	solution	NN
10_1101-2020_06_17_156679	110	7	NMR	NMR	NNP
10_1101-2020_06_17_156679	110	8	signal	signal	NN
10_1101-2020_06_17_156679	110	9	or	or	CC
10_1101-2020_06_17_156679	110	10	produced	produce	VBD
10_1101-2020_06_17_156679	110	11	reference	reference	NN
10_1101-2020_06_17_156679	110	12	1H	1h	CD
10_1101-2020_06_17_156679	110	13	spectra	spectra	NNP
10_1101-2020_06_17_156679	110	14	inconsistent	inconsistent	JJ
10_1101-2020_06_17_156679	110	15	with	with	IN
10_1101-2020_06_17_156679	110	16	the	the	DT
10_1101-2020_06_17_156679	110	17	217	217	CD
10_1101-2020_06_17_156679	110	18	compound	compound	NN
10_1101-2020_06_17_156679	110	19	chemical	chemical	NN
10_1101-2020_06_17_156679	110	20	structure	structure	NN
10_1101-2020_06_17_156679	110	21	;	;	:
10_1101-2020_06_17_156679	110	22	these	these	DT
10_1101-2020_06_17_156679	110	23	ligands	ligand	NNS
10_1101-2020_06_17_156679	110	24	were	be	VBD
10_1101-2020_06_17_156679	110	25	not	not	RB
10_1101-2020_06_17_156679	110	26	evaluated	evaluate	VBN
10_1101-2020_06_17_156679	110	27	further	further	RB
10_1101-2020_06_17_156679	110	28	.	.	.
10_1101-2020_06_17_156679	111	1	Samples	sample	NNS
10_1101-2020_06_17_156679	111	2	of	of	IN
10_1101-2020_06_17_156679	111	3	10	10	CD
10_1101-2020_06_17_156679	111	4	μM	μM	NNP
10_1101-2020_06_17_156679	111	5	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	111	6	and	and	CC
10_1101-2020_06_17_156679	111	7	218	218	CD
10_1101-2020_06_17_156679	111	8	0.8	0.8	CD
10_1101-2020_06_17_156679	111	9	mM	mM	NNP
10_1101-2020_06_17_156679	111	10	nominal	nominal	JJ
10_1101-2020_06_17_156679	111	11	ligand	ligand	NN
10_1101-2020_06_17_156679	111	12	concentration	concentration	NN
10_1101-2020_06_17_156679	111	13	were	be	VBD
10_1101-2020_06_17_156679	111	14	then	then	RB
10_1101-2020_06_17_156679	111	15	formulated	formulate	VBN
10_1101-2020_06_17_156679	111	16	from	from	IN
10_1101-2020_06_17_156679	111	17	the	the	DT
10_1101-2020_06_17_156679	111	18	remaining	remaining	JJ
10_1101-2020_06_17_156679	111	19	34	34	CD
10_1101-2020_06_17_156679	111	20	compounds	compound	NNS
10_1101-2020_06_17_156679	111	21	219	219	CD
10_1101-2020_06_17_156679	111	22	(	(	-LRB-
10_1101-2020_06_17_156679	111	23	Table	table	NN
10_1101-2020_06_17_156679	111	24	S1	S1	NNS
10_1101-2020_06_17_156679	111	25	)	)	-RRB-
10_1101-2020_06_17_156679	111	26	,	,	,
10_1101-2020_06_17_156679	111	27	and	and	CC
10_1101-2020_06_17_156679	111	28	STD	STD	NNP
10_1101-2020_06_17_156679	111	29	-	-	HYPH
10_1101-2020_06_17_156679	111	30	NMR	NMR	NNP
10_1101-2020_06_17_156679	111	31	spectra	spectra	NNP
10_1101-2020_06_17_156679	111	32	were	be	VBD
10_1101-2020_06_17_156679	111	33	recorded	record	VBN
10_1101-2020_06_17_156679	111	34	,	,	,
10_1101-2020_06_17_156679	111	35	from	from	IN
10_1101-2020_06_17_156679	111	36	which	which	WDT
10_1101-2020_06_17_156679	111	37	only	only	RB
10_1101-2020_06_17_156679	111	38	aromatic	aromatic	JJ
10_1101-2020_06_17_156679	111	39	ligand	ligand	NN
10_1101-2020_06_17_156679	111	40	STD	STD	NNP
10_1101-2020_06_17_156679	111	41	signals	signal	NNS
10_1101-2020_06_17_156679	111	42	were	be	VBD
10_1101-2020_06_17_156679	111	43	220	220	CD
10_1101-2020_06_17_156679	111	44	considered	consider	VBN
10_1101-2020_06_17_156679	111	45	for	for	IN
10_1101-2020_06_17_156679	111	46	further	further	JJ
10_1101-2020_06_17_156679	111	47	analysis	analysis	NN
10_1101-2020_06_17_156679	111	48	.	.	.
10_1101-2020_06_17_156679	112	1	221	221	CD
10_1101-2020_06_17_156679	112	2	.CC	.CC	:
10_1101-2020_06_17_156679	112	3	-	-	:
10_1101-2020_06_17_156679	112	4	BY	by	IN
10_1101-2020_06_17_156679	112	5	4.0	4.0	CD
10_1101-2020_06_17_156679	112	6	International	International	NNP
10_1101-2020_06_17_156679	112	7	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	112	8	under	under	IN
10_1101-2020_06_17_156679	112	9	a	a	DT
10_1101-2020_06_17_156679	112	10	(	(	-LRB-
10_1101-2020_06_17_156679	112	11	which	which	WDT
10_1101-2020_06_17_156679	112	12	was	be	VBD
10_1101-2020_06_17_156679	112	13	not	not	RB
10_1101-2020_06_17_156679	112	14	certified	certify	VBN
10_1101-2020_06_17_156679	112	15	by	by	IN
10_1101-2020_06_17_156679	112	16	peer	peer	NN
10_1101-2020_06_17_156679	112	17	review	review	NN
10_1101-2020_06_17_156679	112	18	)	)	-RRB-
10_1101-2020_06_17_156679	112	19	is	be	VBZ
10_1101-2020_06_17_156679	112	20	the	the	DT
10_1101-2020_06_17_156679	112	21	author	author	NN
10_1101-2020_06_17_156679	112	22	/	/	SYM
10_1101-2020_06_17_156679	112	23	funder	funder	NN
10_1101-2020_06_17_156679	112	24	,	,	,
10_1101-2020_06_17_156679	112	25	who	who	WP
10_1101-2020_06_17_156679	112	26	has	have	VBZ
10_1101-2020_06_17_156679	112	27	granted	grant	VBN
10_1101-2020_06_17_156679	112	28	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	112	29	a	a	DT
10_1101-2020_06_17_156679	112	30	license	license	NN
10_1101-2020_06_17_156679	112	31	to	to	TO
10_1101-2020_06_17_156679	112	32	display	display	VB
10_1101-2020_06_17_156679	112	33	the	the	DT
10_1101-2020_06_17_156679	112	34	preprint	preprint	NN
10_1101-2020_06_17_156679	112	35	in	in	IN
10_1101-2020_06_17_156679	112	36	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	112	37	.	.	.
10_1101-2020_06_17_156679	113	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	113	2	is	be	VBZ
10_1101-2020_06_17_156679	113	3	made	make	VBN
10_1101-2020_06_17_156679	113	4	The	the	DT
10_1101-2020_06_17_156679	113	5	copyright	copyright	NN
10_1101-2020_06_17_156679	113	6	holder	holder	NN
10_1101-2020_06_17_156679	113	7	for	for	IN
10_1101-2020_06_17_156679	113	8	this	this	DT
10_1101-2020_06_17_156679	113	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	113	10	version	version	NN
10_1101-2020_06_17_156679	113	11	posted	post	VBD
10_1101-2020_06_17_156679	113	12	January	January	NNP
10_1101-2020_06_17_156679	113	13	6	6	CD
10_1101-2020_06_17_156679	113	14	,	,	,
10_1101-2020_06_17_156679	113	15	2021	2021	CD
10_1101-2020_06_17_156679	113	16	.	.	.
10_1101-2020_06_17_156679	113	17	;	;	:
10_1101-2020_06_17_156679	113	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	113	19	:	:	:
10_1101-2020_06_17_156679	113	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	113	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	113	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	113	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	113	24	9	9	CD
10_1101-2020_06_17_156679	113	25	We	-PRON-	PRP
10_1101-2020_06_17_156679	113	26	observed	observe	VBD
10_1101-2020_06_17_156679	113	27	large	large	JJ
10_1101-2020_06_17_156679	113	28	variations	variation	NNS
10_1101-2020_06_17_156679	113	29	in	in	IN
10_1101-2020_06_17_156679	113	30	STD	STD	NNP
10_1101-2020_06_17_156679	113	31	signal	signal	NN
10_1101-2020_06_17_156679	113	32	intensity	intensity	NN
10_1101-2020_06_17_156679	113	33	and	and	CC
10_1101-2020_06_17_156679	113	34	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	113	35	values	value	NNS
10_1101-2020_06_17_156679	113	36	in	in	IN
10_1101-2020_06_17_156679	113	37	the	the	DT
10_1101-2020_06_17_156679	113	38	presence	presence	NN
10_1101-2020_06_17_156679	113	39	of	of	IN
10_1101-2020_06_17_156679	113	40	M	m	NN
10_1101-2020_06_17_156679	113	41	pro	pro	JJ
10_1101-2020_06_17_156679	113	42	222	222	CD
10_1101-2020_06_17_156679	113	43	across	across	IN
10_1101-2020_06_17_156679	113	44	compounds	compound	NNS
10_1101-2020_06_17_156679	113	45	(	(	-LRB-
10_1101-2020_06_17_156679	113	46	Fig	fig	NN
10_1101-2020_06_17_156679	113	47	.	.	.
10_1101-2020_06_17_156679	114	1	2A	2a	LS
10_1101-2020_06_17_156679	114	2	,	,	,
10_1101-2020_06_17_156679	114	3	B	b	NN
10_1101-2020_06_17_156679	114	4	;	;	:
10_1101-2020_06_17_156679	114	5	Table	table	NN
10_1101-2020_06_17_156679	114	6	S1	S1	NNS
10_1101-2020_06_17_156679	114	7	)	)	-RRB-
10_1101-2020_06_17_156679	114	8	,	,	,
10_1101-2020_06_17_156679	114	9	with	with	IN
10_1101-2020_06_17_156679	114	10	many	many	JJ
10_1101-2020_06_17_156679	114	11	ligands	ligand	NNS
10_1101-2020_06_17_156679	114	12	producing	produce	VBG
10_1101-2020_06_17_156679	114	13	little	little	JJ
10_1101-2020_06_17_156679	114	14	or	or	CC
10_1101-2020_06_17_156679	114	15	no	no	DT
10_1101-2020_06_17_156679	114	16	STD	STD	NNP
10_1101-2020_06_17_156679	114	17	signal	signal	NN
10_1101-2020_06_17_156679	114	18	,	,	,
10_1101-2020_06_17_156679	114	19	223	223	CD
10_1101-2020_06_17_156679	114	20	suggesting	suggest	VBG
10_1101-2020_06_17_156679	114	21	substantial	substantial	JJ
10_1101-2020_06_17_156679	114	22	differences	difference	NNS
10_1101-2020_06_17_156679	114	23	in	in	IN
10_1101-2020_06_17_156679	114	24	compound	compound	NN
10_1101-2020_06_17_156679	114	25	affinity	affinity	NN
10_1101-2020_06_17_156679	114	26	for	for	IN
10_1101-2020_06_17_156679	114	27	the	the	DT
10_1101-2020_06_17_156679	114	28	protease	protease	NN
10_1101-2020_06_17_156679	114	29	.	.	.
10_1101-2020_06_17_156679	115	1	However	however	RB
10_1101-2020_06_17_156679	115	2	,	,	,
10_1101-2020_06_17_156679	115	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	115	4	also	also	RB
10_1101-2020_06_17_156679	115	5	noted	note	VBD
10_1101-2020_06_17_156679	115	6	224	224	CD
10_1101-2020_06_17_156679	115	7	that	that	DT
10_1101-2020_06_17_156679	115	8	ligand	ligand	NNP
10_1101-2020_06_17_156679	115	9	reference	reference	NN
10_1101-2020_06_17_156679	115	10	spectra	spectra	NNP
10_1101-2020_06_17_156679	115	11	different	different	JJ
10_1101-2020_06_17_156679	115	12	substantially	substantially	RB
10_1101-2020_06_17_156679	115	13	in	in	IN
10_1101-2020_06_17_156679	115	14	intensity	intensity	NN
10_1101-2020_06_17_156679	115	15	(	(	-LRB-
10_1101-2020_06_17_156679	115	16	Fig	fig	NN
10_1101-2020_06_17_156679	115	17	.	.	.
10_1101-2020_06_17_156679	116	1	2C	2C	NNP
10_1101-2020_06_17_156679	116	2	)	)	-RRB-
10_1101-2020_06_17_156679	116	3	,	,	,
10_1101-2020_06_17_156679	116	4	despite	despite	IN
10_1101-2020_06_17_156679	116	5	compounds	compound	NNS
10_1101-2020_06_17_156679	116	6	being	be	VBG
10_1101-2020_06_17_156679	116	7	225	225	CD
10_1101-2020_06_17_156679	116	8	at	at	IN
10_1101-2020_06_17_156679	116	9	the	the	DT
10_1101-2020_06_17_156679	116	10	same	same	JJ
10_1101-2020_06_17_156679	116	11	nominal	nominal	JJ
10_1101-2020_06_17_156679	116	12	concentration	concentration	NN
10_1101-2020_06_17_156679	116	13	.	.	.
10_1101-2020_06_17_156679	117	1	Integrating	integrate	VBG
10_1101-2020_06_17_156679	117	2	ligand	ligand	NN
10_1101-2020_06_17_156679	117	3	peaks	peak	NNS
10_1101-2020_06_17_156679	117	4	in	in	IN
10_1101-2020_06_17_156679	117	5	these	these	DT
10_1101-2020_06_17_156679	117	6	reference	reference	NN
10_1101-2020_06_17_156679	117	7	spectra	spectra	NNP
10_1101-2020_06_17_156679	117	8	revealed	reveal	VBD
10_1101-2020_06_17_156679	117	9	226	226	CD
10_1101-2020_06_17_156679	117	10	differences	difference	NNS
10_1101-2020_06_17_156679	117	11	in	in	IN
10_1101-2020_06_17_156679	117	12	per-1H	per-1h	NN
10_1101-2020_06_17_156679	117	13	intensity	intensity	NN
10_1101-2020_06_17_156679	117	14	of	of	IN
10_1101-2020_06_17_156679	117	15	up	up	IN
10_1101-2020_06_17_156679	117	16	to	to	IN
10_1101-2020_06_17_156679	117	17	~15-fold	~15-fold	NNP
10_1101-2020_06_17_156679	117	18	,	,	,
10_1101-2020_06_17_156679	117	19	indicating	indicate	VBG
10_1101-2020_06_17_156679	117	20	significant	significant	JJ
10_1101-2020_06_17_156679	117	21	variation	variation	NN
10_1101-2020_06_17_156679	117	22	of	of	IN
10_1101-2020_06_17_156679	117	23	ligand	ligand	NNP
10_1101-2020_06_17_156679	117	24	227	227	CD
10_1101-2020_06_17_156679	117	25	concentrations	concentration	NNS
10_1101-2020_06_17_156679	117	26	in	in	IN
10_1101-2020_06_17_156679	117	27	solution	solution	NN
10_1101-2020_06_17_156679	117	28	(	(	-LRB-
10_1101-2020_06_17_156679	117	29	Table	table	NN
10_1101-2020_06_17_156679	117	30	S1	s1	NN
10_1101-2020_06_17_156679	117	31	)	)	-RRB-
10_1101-2020_06_17_156679	117	32	.	.	.
10_1101-2020_06_17_156679	118	1	Such	such	JJ
10_1101-2020_06_17_156679	118	2	concentration	concentration	NN
10_1101-2020_06_17_156679	118	3	differences	difference	NNS
10_1101-2020_06_17_156679	118	4	could	could	MD
10_1101-2020_06_17_156679	118	5	arise	arise	VB
10_1101-2020_06_17_156679	118	6	from	from	IN
10_1101-2020_06_17_156679	118	7	errors	error	NNS
10_1101-2020_06_17_156679	118	8	in	in	IN
10_1101-2020_06_17_156679	118	9	228	228	CD
10_1101-2020_06_17_156679	118	10	sample	sample	NN
10_1101-2020_06_17_156679	118	11	formulation	formulation	NN
10_1101-2020_06_17_156679	118	12	or	or	CC
10_1101-2020_06_17_156679	118	13	from	from	IN
10_1101-2020_06_17_156679	118	14	concentration	concentration	NN
10_1101-2020_06_17_156679	118	15	inconsistencies	inconsistency	NNS
10_1101-2020_06_17_156679	118	16	in	in	IN
10_1101-2020_06_17_156679	118	17	the	the	DT
10_1101-2020_06_17_156679	118	18	compound	compound	NN
10_1101-2020_06_17_156679	118	19	library	library	NN
10_1101-2020_06_17_156679	118	20	.	.	.
10_1101-2020_06_17_156679	119	1	To	to	TO
10_1101-2020_06_17_156679	119	2	evaluate	evaluate	VB
10_1101-2020_06_17_156679	119	3	the	the	DT
10_1101-2020_06_17_156679	119	4	229	229	CD
10_1101-2020_06_17_156679	119	5	former	former	JJ
10_1101-2020_06_17_156679	119	6	we	-PRON-	PRP
10_1101-2020_06_17_156679	119	7	also	also	RB
10_1101-2020_06_17_156679	119	8	integrated	integrate	VBD
10_1101-2020_06_17_156679	119	9	the	the	DT
10_1101-2020_06_17_156679	119	10	residual	residual	JJ
10_1101-2020_06_17_156679	119	11	1H	1h	JJ
10_1101-2020_06_17_156679	119	12	signal	signal	NN
10_1101-2020_06_17_156679	119	13	of	of	IN
10_1101-2020_06_17_156679	119	14	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	119	15	in	in	IN
10_1101-2020_06_17_156679	119	16	our	-PRON-	PRP$
10_1101-2020_06_17_156679	119	17	reference	reference	NN
10_1101-2020_06_17_156679	119	18	spectra	spectra	NN
10_1101-2020_06_17_156679	119	19	,	,	,
10_1101-2020_06_17_156679	119	20	and	and	CC
10_1101-2020_06_17_156679	119	21	found	find	VBD
10_1101-2020_06_17_156679	119	22	it	-PRON-	PRP
10_1101-2020_06_17_156679	119	23	to	to	IN
10_1101-2020_06_17_156679	119	24	230	230	CD
10_1101-2020_06_17_156679	119	25	vary	vary	VBP
10_1101-2020_06_17_156679	119	26	by	by	IN
10_1101-2020_06_17_156679	119	27	less	less	JJR
10_1101-2020_06_17_156679	119	28	than	than	IN
10_1101-2020_06_17_156679	119	29	35	35	CD
10_1101-2020_06_17_156679	119	30	%	%	NN
10_1101-2020_06_17_156679	119	31	across	across	IN
10_1101-2020_06_17_156679	119	32	any	any	DT
10_1101-2020_06_17_156679	119	33	pair	pair	NN
10_1101-2020_06_17_156679	119	34	of	of	IN
10_1101-2020_06_17_156679	119	35	samples	sample	NNS
10_1101-2020_06_17_156679	119	36	(	(	-LRB-
10_1101-2020_06_17_156679	119	37	11	11	CD
10_1101-2020_06_17_156679	119	38	%	%	NN
10_1101-2020_06_17_156679	119	39	average	average	JJ
10_1101-2020_06_17_156679	119	40	deviation	deviation	NN
10_1101-2020_06_17_156679	119	41	)	)	-RRB-
10_1101-2020_06_17_156679	119	42	.	.	.
10_1101-2020_06_17_156679	120	1	As	as	IN
10_1101-2020_06_17_156679	120	2	DMSO	DMSO	NNP
10_1101-2020_06_17_156679	120	3	was	be	VBD
10_1101-2020_06_17_156679	120	4	added	add	VBN
10_1101-2020_06_17_156679	120	5	231	231	CD
10_1101-2020_06_17_156679	120	6	alongside	alongside	RB
10_1101-2020_06_17_156679	120	7	ligands	ligand	NNS
10_1101-2020_06_17_156679	120	8	in	in	IN
10_1101-2020_06_17_156679	120	9	our	-PRON-	PRP$
10_1101-2020_06_17_156679	120	10	samples	sample	NNS
10_1101-2020_06_17_156679	120	11	,	,	,
10_1101-2020_06_17_156679	120	12	we	-PRON-	PRP
10_1101-2020_06_17_156679	120	13	concluded	conclude	VBD
10_1101-2020_06_17_156679	120	14	that	that	IN
10_1101-2020_06_17_156679	120	15	sample	sample	NN
10_1101-2020_06_17_156679	120	16	formulation	formulation	NN
10_1101-2020_06_17_156679	120	17	may	may	MD
10_1101-2020_06_17_156679	120	18	have	have	VB
10_1101-2020_06_17_156679	120	19	contributed	contribute	VBN
10_1101-2020_06_17_156679	120	20	232	232	CD
10_1101-2020_06_17_156679	120	21	errors	error	NNS
10_1101-2020_06_17_156679	120	22	in	in	IN
10_1101-2020_06_17_156679	120	23	compound	compound	JJ
10_1101-2020_06_17_156679	120	24	concentration	concentration	NN
10_1101-2020_06_17_156679	120	25	of	of	IN
10_1101-2020_06_17_156679	120	26	up	up	IN
10_1101-2020_06_17_156679	120	27	to	to	IN
10_1101-2020_06_17_156679	120	28	~1/3	~1/3	.
10_1101-2020_06_17_156679	120	29	,	,	,
10_1101-2020_06_17_156679	120	30	but	but	CC
10_1101-2020_06_17_156679	120	31	did	do	VBD
10_1101-2020_06_17_156679	120	32	not	not	RB
10_1101-2020_06_17_156679	120	33	account	account	VB
10_1101-2020_06_17_156679	120	34	for	for	IN
10_1101-2020_06_17_156679	120	35	the	the	DT
10_1101-2020_06_17_156679	120	36	~15-fold	~15-fold	JJ
10_1101-2020_06_17_156679	120	37	differences	difference	NNS
10_1101-2020_06_17_156679	120	38	in	in	IN
10_1101-2020_06_17_156679	120	39	233	233	CD
10_1101-2020_06_17_156679	120	40	concentration	concentration	NN
10_1101-2020_06_17_156679	120	41	observed	observe	VBN
10_1101-2020_06_17_156679	120	42	.	.	.
10_1101-2020_06_17_156679	121	1	234	234	CD
10_1101-2020_06_17_156679	121	2	Given	give	VBN
10_1101-2020_06_17_156679	121	3	that	that	IN
10_1101-2020_06_17_156679	121	4	differences	difference	NNS
10_1101-2020_06_17_156679	121	5	in	in	IN
10_1101-2020_06_17_156679	121	6	compound	compound	NN
10_1101-2020_06_17_156679	121	7	concentration	concentration	NN
10_1101-2020_06_17_156679	121	8	can	can	MD
10_1101-2020_06_17_156679	121	9	skew	skew	VB
10_1101-2020_06_17_156679	121	10	the	the	DT
10_1101-2020_06_17_156679	121	11	relative	relative	JJ
10_1101-2020_06_17_156679	121	12	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	121	13	values	value	NNS
10_1101-2020_06_17_156679	121	14	of	of	IN
10_1101-2020_06_17_156679	121	15	ligands	ligand	NNS
10_1101-2020_06_17_156679	121	16	235	235	CD
10_1101-2020_06_17_156679	121	17	(	(	-LRB-
10_1101-2020_06_17_156679	121	18	Fig	fig	NN
10_1101-2020_06_17_156679	121	19	.	.	.
10_1101-2020_06_17_156679	122	1	S1	S1	NNP
10_1101-2020_06_17_156679	122	2	)	)	-RRB-
10_1101-2020_06_17_156679	122	3	,	,	,
10_1101-2020_06_17_156679	122	4	and	and	CC
10_1101-2020_06_17_156679	122	5	that	that	IN
10_1101-2020_06_17_156679	122	6	such	such	JJ
10_1101-2020_06_17_156679	122	7	concentration	concentration	NN
10_1101-2020_06_17_156679	122	8	differences	difference	NNS
10_1101-2020_06_17_156679	122	9	were	be	VBD
10_1101-2020_06_17_156679	122	10	also	also	RB
10_1101-2020_06_17_156679	122	11	observed	observe	VBN
10_1101-2020_06_17_156679	122	12	among	among	IN
10_1101-2020_06_17_156679	122	13	newly	newly	RB
10_1101-2020_06_17_156679	122	14	designed	design	VBN
10_1101-2020_06_17_156679	122	15	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	122	16	236	236	CD
10_1101-2020_06_17_156679	122	17	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	122	18	(	(	-LRB-
10_1101-2020_06_17_156679	122	19	see	see	VB
10_1101-2020_06_17_156679	122	20	below	below	RB
10_1101-2020_06_17_156679	122	21	)	)	-RRB-
10_1101-2020_06_17_156679	122	22	,	,	,
10_1101-2020_06_17_156679	122	23	we	-PRON-	PRP
10_1101-2020_06_17_156679	122	24	questioned	question	VBD
10_1101-2020_06_17_156679	122	25	whether	whether	IN
10_1101-2020_06_17_156679	122	26	recording	record	VBG
10_1101-2020_06_17_156679	122	27	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	122	28	values	value	NNS
10_1101-2020_06_17_156679	122	29	under	under	IN
10_1101-2020_06_17_156679	122	30	these	these	DT
10_1101-2020_06_17_156679	122	31	conditions	condition	NNS
10_1101-2020_06_17_156679	122	32	can	can	MD
10_1101-2020_06_17_156679	122	33	237	237	CD
10_1101-2020_06_17_156679	122	34	provide	provide	VB
10_1101-2020_06_17_156679	122	35	useful	useful	JJ
10_1101-2020_06_17_156679	122	36	information	information	NN
10_1101-2020_06_17_156679	122	37	.	.	.
10_1101-2020_06_17_156679	123	1	To	to	TO
10_1101-2020_06_17_156679	123	2	address	address	VB
10_1101-2020_06_17_156679	123	3	this	this	DT
10_1101-2020_06_17_156679	123	4	question	question	NN
10_1101-2020_06_17_156679	123	5	we	-PRON-	PRP
10_1101-2020_06_17_156679	123	6	attempted	attempt	VBD
10_1101-2020_06_17_156679	123	7	to	to	TO
10_1101-2020_06_17_156679	123	8	quantify	quantify	VB
10_1101-2020_06_17_156679	123	9	the	the	DT
10_1101-2020_06_17_156679	123	10	affinity	affinity	NN
10_1101-2020_06_17_156679	123	11	of	of	IN
10_1101-2020_06_17_156679	123	12	238	238	CD
10_1101-2020_06_17_156679	123	13	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	123	14	fragments	fragment	NNS
10_1101-2020_06_17_156679	123	15	to	to	IN
10_1101-2020_06_17_156679	123	16	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	123	17	,	,	,
10_1101-2020_06_17_156679	123	18	selecting	select	VBG
10_1101-2020_06_17_156679	123	19	ligands	ligand	NNS
10_1101-2020_06_17_156679	123	20	that	that	WDT
10_1101-2020_06_17_156679	123	21	showed	show	VBD
10_1101-2020_06_17_156679	123	22	clear	clear	JJ
10_1101-2020_06_17_156679	123	23	differences	difference	NNS
10_1101-2020_06_17_156679	123	24	in	in	IN
10_1101-2020_06_17_156679	123	25	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	123	26	values	value	NNS
10_1101-2020_06_17_156679	123	27	239	239	CD
10_1101-2020_06_17_156679	123	28	in	in	IN
10_1101-2020_06_17_156679	123	29	the	the	DT
10_1101-2020_06_17_156679	123	30	assays	assay	NNS
10_1101-2020_06_17_156679	123	31	above	above	RB
10_1101-2020_06_17_156679	123	32	and	and	CC
10_1101-2020_06_17_156679	123	33	focusing	focus	VBG
10_1101-2020_06_17_156679	123	34	on	on	IN
10_1101-2020_06_17_156679	123	35	compounds	compound	NNS
10_1101-2020_06_17_156679	123	36	binding	bind	VBG
10_1101-2020_06_17_156679	123	37	at	at	IN
10_1101-2020_06_17_156679	123	38	the	the	DT
10_1101-2020_06_17_156679	123	39	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	123	40	active	active	JJ
10_1101-2020_06_17_156679	123	41	site	site	NN
10_1101-2020_06_17_156679	123	42	;	;	:
10_1101-2020_06_17_156679	123	43	hence	hence	RB
10_1101-2020_06_17_156679	123	44	,	,	,
10_1101-2020_06_17_156679	123	45	that	that	DT
10_1101-2020_06_17_156679	123	46	are	be	VBP
10_1101-2020_06_17_156679	123	47	of	of	IN
10_1101-2020_06_17_156679	123	48	240	240	CD
10_1101-2020_06_17_156679	123	49	potential	potential	JJ
10_1101-2020_06_17_156679	123	50	interest	interest	NN
10_1101-2020_06_17_156679	123	51	to	to	TO
10_1101-2020_06_17_156679	123	52	inhibitor	inhibitor	VB
10_1101-2020_06_17_156679	123	53	development	development	NN
10_1101-2020_06_17_156679	123	54	.	.	.
10_1101-2020_06_17_156679	124	1	We	-PRON-	PRP
10_1101-2020_06_17_156679	124	2	performed	perform	VBD
10_1101-2020_06_17_156679	124	3	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	124	4	binding	bind	VBG
10_1101-2020_06_17_156679	124	5	titrations	titration	NNS
10_1101-2020_06_17_156679	124	6	monitored	monitor	VBN
10_1101-2020_06_17_156679	124	7	by	by	IN
10_1101-2020_06_17_156679	124	8	STD-241	STD-241	NNP
10_1101-2020_06_17_156679	124	9	NMR	NMR	NNP
10_1101-2020_06_17_156679	124	10	of	of	IN
10_1101-2020_06_17_156679	124	11	compounds	compound	NNS
10_1101-2020_06_17_156679	124	12	x0195	x0195	NNP
10_1101-2020_06_17_156679	124	13	,	,	,
10_1101-2020_06_17_156679	124	14	x0354	x0354	NNP
10_1101-2020_06_17_156679	124	15	,	,	,
10_1101-2020_06_17_156679	124	16	x0426	x0426	NNP
10_1101-2020_06_17_156679	124	17	and	and	CC
10_1101-2020_06_17_156679	124	18	x0434	x0434	NNP
10_1101-2020_06_17_156679	124	19	in	in	IN
10_1101-2020_06_17_156679	124	20	50	50	CD
10_1101-2020_06_17_156679	124	21	μM	μM	NNP
10_1101-2020_06_17_156679	124	22	–	–	:
10_1101-2020_06_17_156679	124	23	4	4	CD
10_1101-2020_06_17_156679	124	24	mM	mM	NNP
10_1101-2020_06_17_156679	124	25	concentrations	concentration	NNS
10_1101-2020_06_17_156679	124	26	(	(	-LRB-
10_1101-2020_06_17_156679	124	27	Fig	fig	NN
10_1101-2020_06_17_156679	124	28	.	.	.
10_1101-2020_06_17_156679	125	1	S2	s2	NN
10_1101-2020_06_17_156679	125	2	)	)	-RRB-
10_1101-2020_06_17_156679	125	3	,	,	,
10_1101-2020_06_17_156679	125	4	and	and	CC
10_1101-2020_06_17_156679	125	5	242	242	CD
10_1101-2020_06_17_156679	125	6	noted	note	VBD
10_1101-2020_06_17_156679	125	7	that	that	IN
10_1101-2020_06_17_156679	125	8	only	only	RB
10_1101-2020_06_17_156679	125	9	compounds	compound	VBZ
10_1101-2020_06_17_156679	125	10	x0434	x0434	NNP
10_1101-2020_06_17_156679	125	11	and	and	CC
10_1101-2020_06_17_156679	125	12	x0195	x0195	NNP
10_1101-2020_06_17_156679	125	13	,	,	,
10_1101-2020_06_17_156679	125	14	which	which	WDT
10_1101-2020_06_17_156679	125	15	show	show	VBP
10_1101-2020_06_17_156679	125	16	the	the	DT
10_1101-2020_06_17_156679	125	17	highest	high	JJS
10_1101-2020_06_17_156679	125	18	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	125	19	(	(	-LRB-
10_1101-2020_06_17_156679	125	20	Fig	fig	NN
10_1101-2020_06_17_156679	125	21	.	.	.
10_1101-2020_06_17_156679	126	1	2A	2a	LS
10_1101-2020_06_17_156679	126	2	)	)	-RRB-
10_1101-2020_06_17_156679	126	3	,	,	,
10_1101-2020_06_17_156679	126	4	bound	bind	VBD
10_1101-2020_06_17_156679	126	5	243	243	CD
10_1101-2020_06_17_156679	126	6	strongly	strongly	RB
10_1101-2020_06_17_156679	126	7	enough	enough	JJ
10_1101-2020_06_17_156679	126	8	for	for	IN
10_1101-2020_06_17_156679	126	9	an	an	DT
10_1101-2020_06_17_156679	126	10	affinity	affinity	NN
10_1101-2020_06_17_156679	126	11	constant	constant	JJ
10_1101-2020_06_17_156679	126	12	to	to	TO
10_1101-2020_06_17_156679	126	13	be	be	VB
10_1101-2020_06_17_156679	126	14	estimated	estimate	VBN
10_1101-2020_06_17_156679	126	15	(	(	-LRB-
10_1101-2020_06_17_156679	126	16	Kd	Kd	NNP
10_1101-2020_06_17_156679	126	17	of	of	IN
10_1101-2020_06_17_156679	126	18	1.6	1.6	CD
10_1101-2020_06_17_156679	126	19	±	±	CD
10_1101-2020_06_17_156679	126	20	0.2	0.2	CD
10_1101-2020_06_17_156679	126	21	mM	mM	NNP
10_1101-2020_06_17_156679	126	22	and	and	CC
10_1101-2020_06_17_156679	126	23	1.7	1.7	CD
10_1101-2020_06_17_156679	126	24	±	±	CD
10_1101-2020_06_17_156679	126	25	0.2	0.2	CD
10_1101-2020_06_17_156679	126	26	mM	mM	NNP
10_1101-2020_06_17_156679	126	27	,	,	,
10_1101-2020_06_17_156679	126	28	244	244	CD
10_1101-2020_06_17_156679	126	29	respectively	respectively	RB
10_1101-2020_06_17_156679	126	30	)	)	-RRB-
10_1101-2020_06_17_156679	126	31	.	.	.
10_1101-2020_06_17_156679	127	1	In	in	IN
10_1101-2020_06_17_156679	127	2	contrast	contrast	NN
10_1101-2020_06_17_156679	127	3	,	,	,
10_1101-2020_06_17_156679	127	4	the	the	DT
10_1101-2020_06_17_156679	127	5	titrations	titration	NNS
10_1101-2020_06_17_156679	127	6	of	of	IN
10_1101-2020_06_17_156679	127	7	x0354	x0354	NNP
10_1101-2020_06_17_156679	127	8	and	and	CC
10_1101-2020_06_17_156679	127	9	x0426	x0426	NNP
10_1101-2020_06_17_156679	127	10	,	,	,
10_1101-2020_06_17_156679	127	11	which	which	WDT
10_1101-2020_06_17_156679	127	12	yielded	yield	VBD
10_1101-2020_06_17_156679	127	13	lower	low	JJR
10_1101-2020_06_17_156679	127	14	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	127	15	values	value	NNS
10_1101-2020_06_17_156679	127	16	,	,	,
10_1101-2020_06_17_156679	127	17	245	245	CD
10_1101-2020_06_17_156679	127	18	could	could	MD
10_1101-2020_06_17_156679	127	19	not	not	RB
10_1101-2020_06_17_156679	127	20	be	be	VB
10_1101-2020_06_17_156679	127	21	fit	fit	JJ
10_1101-2020_06_17_156679	127	22	to	to	TO
10_1101-2020_06_17_156679	127	23	extract	extract	VB
10_1101-2020_06_17_156679	127	24	a	a	DT
10_1101-2020_06_17_156679	127	25	Kd	Kd	NNP
10_1101-2020_06_17_156679	127	26	indicating	indicate	VBG
10_1101-2020_06_17_156679	127	27	weaker	weak	JJR
10_1101-2020_06_17_156679	127	28	binding	bind	VBG
10_1101-2020_06_17_156679	127	29	to	to	IN
10_1101-2020_06_17_156679	127	30	M	M	NNP
10_1101-2020_06_17_156679	127	31	pro	pro	NN
10_1101-2020_06_17_156679	127	32	.	.	.
10_1101-2020_06_17_156679	128	1	246	246	CD
10_1101-2020_06_17_156679	128	2	To	to	TO
10_1101-2020_06_17_156679	128	3	further	further	RB
10_1101-2020_06_17_156679	128	4	this	this	DT
10_1101-2020_06_17_156679	128	5	analysis	analysis	NN
10_1101-2020_06_17_156679	128	6	,	,	,
10_1101-2020_06_17_156679	128	7	we	-PRON-	PRP
10_1101-2020_06_17_156679	128	8	assessed	assess	VBD
10_1101-2020_06_17_156679	128	9	the	the	DT
10_1101-2020_06_17_156679	128	10	binding	binding	NN
10_1101-2020_06_17_156679	128	11	of	of	IN
10_1101-2020_06_17_156679	128	12	fragments	fragment	NNS
10_1101-2020_06_17_156679	128	13	x0195	x0195	NNP
10_1101-2020_06_17_156679	128	14	,	,	,
10_1101-2020_06_17_156679	128	15	x0387	x0387	NNP
10_1101-2020_06_17_156679	128	16	,	,	,
10_1101-2020_06_17_156679	128	17	x0397	x0397	NNP
10_1101-2020_06_17_156679	128	18	,	,	,
10_1101-2020_06_17_156679	128	19	x0426	x0426	NNP
10_1101-2020_06_17_156679	128	20	,	,	,
10_1101-2020_06_17_156679	128	21	x0434	x0434	NNP
10_1101-2020_06_17_156679	128	22	247	247	CD
10_1101-2020_06_17_156679	128	23	and	and	CC
10_1101-2020_06_17_156679	128	24	x0540	x0540	NNP
10_1101-2020_06_17_156679	128	25	to	to	IN
10_1101-2020_06_17_156679	128	26	the	the	DT
10_1101-2020_06_17_156679	128	27	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	128	28	active	active	JJ
10_1101-2020_06_17_156679	128	29	site	site	NN
10_1101-2020_06_17_156679	128	30	using	use	VBG
10_1101-2020_06_17_156679	128	31	quadruplicate	quadruplicate	JJ
10_1101-2020_06_17_156679	128	32	atomistic	atomistic	JJ
10_1101-2020_06_17_156679	128	33	molecular	molecular	JJ
10_1101-2020_06_17_156679	128	34	dynamics	dynamic	NNS
10_1101-2020_06_17_156679	128	35	(	(	-LRB-
10_1101-2020_06_17_156679	128	36	MD	MD	NNP
10_1101-2020_06_17_156679	128	37	)	)	-RRB-
10_1101-2020_06_17_156679	128	38	simulations	simulation	NNS
10_1101-2020_06_17_156679	128	39	248	248	CD
10_1101-2020_06_17_156679	128	40	of	of	IN
10_1101-2020_06_17_156679	128	41	200	200	CD
10_1101-2020_06_17_156679	128	42	nsec	nsec	JJ
10_1101-2020_06_17_156679	128	43	duration	duration	NN
10_1101-2020_06_17_156679	128	44	.	.	.
10_1101-2020_06_17_156679	129	1	As	as	IN
10_1101-2020_06_17_156679	129	2	shown	show	VBN
10_1101-2020_06_17_156679	129	3	in	in	IN
10_1101-2020_06_17_156679	129	4	Fig	Fig	NNP
10_1101-2020_06_17_156679	129	5	.	.	.
10_1101-2020_06_17_156679	130	1	S3A	s3a	NN
10_1101-2020_06_17_156679	130	2	,	,	,
10_1101-2020_06_17_156679	130	3	B	b	NN
10_1101-2020_06_17_156679	130	4	,	,	,
10_1101-2020_06_17_156679	130	5	and	and	CC
10_1101-2020_06_17_156679	130	6	Movies	movie	NNS
10_1101-2020_06_17_156679	130	7	S1	S1	NNS
10_1101-2020_06_17_156679	130	8	and	and	CC
10_1101-2020_06_17_156679	130	9	S2	s2	NN
10_1101-2020_06_17_156679	130	10	,	,	,
10_1101-2020_06_17_156679	130	11	fragments	fragment	VBZ
10_1101-2020_06_17_156679	130	12	with	with	IN
10_1101-2020_06_17_156679	130	13	high	high	JJ
10_1101-2020_06_17_156679	130	14	STDradio	stdradio	NN
10_1101-2020_06_17_156679	130	15	249	249	CD
10_1101-2020_06_17_156679	130	16	values	value	NNS
10_1101-2020_06_17_156679	130	17	(	(	-LRB-
10_1101-2020_06_17_156679	130	18	x0434	x0434	NNP
10_1101-2020_06_17_156679	130	19	and	and	CC
10_1101-2020_06_17_156679	130	20	x0195	x0195	NNP
10_1101-2020_06_17_156679	130	21	)	)	-RRB-
10_1101-2020_06_17_156679	130	22	always	always	RB
10_1101-2020_06_17_156679	130	23	located	locate	VBN
10_1101-2020_06_17_156679	130	24	in	in	IN
10_1101-2020_06_17_156679	130	25	the	the	DT
10_1101-2020_06_17_156679	130	26	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	130	27	active	active	JJ
10_1101-2020_06_17_156679	130	28	site	site	NN
10_1101-2020_06_17_156679	130	29	despite	despite	IN
10_1101-2020_06_17_156679	130	30	exchanging	exchange	VBG
10_1101-2020_06_17_156679	130	31	between	between	IN
10_1101-2020_06_17_156679	130	32	250	250	CD
10_1101-2020_06_17_156679	130	33	different	different	JJ
10_1101-2020_06_17_156679	130	34	binding	bind	VBG
10_1101-2020_06_17_156679	130	35	conformations	conformation	NNS
10_1101-2020_06_17_156679	130	36	(	(	-LRB-
10_1101-2020_06_17_156679	130	37	Fig	fig	NN
10_1101-2020_06_17_156679	130	38	.	.	.
10_1101-2020_06_17_156679	131	1	S4	S4	NNP
10_1101-2020_06_17_156679	131	2	)	)	-RRB-
10_1101-2020_06_17_156679	131	3	,	,	,
10_1101-2020_06_17_156679	131	4	with	with	IN
10_1101-2020_06_17_156679	131	5	average	average	JJ
10_1101-2020_06_17_156679	131	6	ligand	ligand	NN
10_1101-2020_06_17_156679	131	7	root	root	NN
10_1101-2020_06_17_156679	131	8	-	-	HYPH
10_1101-2020_06_17_156679	131	9	mean	mean	JJ
10_1101-2020_06_17_156679	131	10	-	-	HYPH
10_1101-2020_06_17_156679	131	11	square	square	JJ
10_1101-2020_06_17_156679	131	12	-	-	HYPH
10_1101-2020_06_17_156679	131	13	deviation	deviation	NN
10_1101-2020_06_17_156679	131	14	(	(	-LRB-
10_1101-2020_06_17_156679	131	15	RMSD	RMSD	NNP
10_1101-2020_06_17_156679	131	16	)	)	-RRB-
10_1101-2020_06_17_156679	131	17	of	of	IN
10_1101-2020_06_17_156679	131	18	251	251	CD
10_1101-2020_06_17_156679	131	19	3.2	3.2	CD
10_1101-2020_06_17_156679	131	20	Å	å	NN
10_1101-2020_06_17_156679	131	21	and	and	CC
10_1101-2020_06_17_156679	131	22	5.1	5.1	CD
10_1101-2020_06_17_156679	131	23	Å	å	NN
10_1101-2020_06_17_156679	131	24	respectively	respectively	RB
10_1101-2020_06_17_156679	131	25	after	after	IN
10_1101-2020_06_17_156679	131	26	the	the	DT
10_1101-2020_06_17_156679	131	27	first	first	JJ
10_1101-2020_06_17_156679	131	28	100	100	CD
10_1101-2020_06_17_156679	131	29	nsec	nsec	JJ
10_1101-2020_06_17_156679	131	30	of	of	IN
10_1101-2020_06_17_156679	131	31	simulation	simulation	NN
10_1101-2020_06_17_156679	131	32	.	.	.
10_1101-2020_06_17_156679	132	1	Medium	Medium	NNP
10_1101-2020_06_17_156679	132	2	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	132	3	value	value	NN
10_1101-2020_06_17_156679	132	4	fragments	fragment	VBZ
10_1101-2020_06_17_156679	132	5	252	252	CD
10_1101-2020_06_17_156679	132	6	(	(	-LRB-
10_1101-2020_06_17_156679	132	7	x0426	x0426	NNP
10_1101-2020_06_17_156679	132	8	and	and	CC
10_1101-2020_06_17_156679	132	9	x0540	x0540	NNP
10_1101-2020_06_17_156679	132	10	,	,	,
10_1101-2020_06_17_156679	132	11	Fig	Fig	NNP
10_1101-2020_06_17_156679	132	12	.	.	.
10_1101-2020_06_17_156679	133	1	S3C	S3C	NNS
10_1101-2020_06_17_156679	133	2	,	,	,
10_1101-2020_06_17_156679	133	3	D	d	NN
10_1101-2020_06_17_156679	133	4	,	,	,
10_1101-2020_06_17_156679	133	5	and	and	CC
10_1101-2020_06_17_156679	133	6	Movies	Movies	NNPS
10_1101-2020_06_17_156679	133	7	S3	S3	NNP
10_1101-2020_06_17_156679	133	8	and	and	CC
10_1101-2020_06_17_156679	133	9	S4	S4	NNP
10_1101-2020_06_17_156679	133	10	)	)	-RRB-
10_1101-2020_06_17_156679	133	11	show	show	VBP
10_1101-2020_06_17_156679	133	12	average	average	JJ
10_1101-2020_06_17_156679	133	13	RMSDs	rmsd	NNS
10_1101-2020_06_17_156679	133	14	of	of	IN
10_1101-2020_06_17_156679	133	15	approximately	approximately	RB
10_1101-2020_06_17_156679	133	16	9	9	CD
10_1101-2020_06_17_156679	133	17	Å	å	NN
10_1101-2020_06_17_156679	133	18	in	in	IN
10_1101-2020_06_17_156679	133	19	253	253	CD
10_1101-2020_06_17_156679	133	20	the	the	DT
10_1101-2020_06_17_156679	133	21	same	same	JJ
10_1101-2020_06_17_156679	133	22	simulation	simulation	NN
10_1101-2020_06_17_156679	133	23	timeframe	timeframe	NN
10_1101-2020_06_17_156679	133	24	,	,	,
10_1101-2020_06_17_156679	133	25	frequently	frequently	RB
10_1101-2020_06_17_156679	133	26	exchanging	exchange	VBG
10_1101-2020_06_17_156679	133	27	to	to	IN
10_1101-2020_06_17_156679	133	28	alternative	alternative	JJ
10_1101-2020_06_17_156679	133	29	binding	bind	VBG
10_1101-2020_06_17_156679	133	30	poses	pose	NNS
10_1101-2020_06_17_156679	133	31	and	and	CC
10_1101-2020_06_17_156679	133	32	with	with	IN
10_1101-2020_06_17_156679	133	33	x0540	x0540	NNP
10_1101-2020_06_17_156679	133	34	254	254	CD
10_1101-2020_06_17_156679	133	35	occasionally	occasionally	RB
10_1101-2020_06_17_156679	133	36	exiting	exit	VBG
10_1101-2020_06_17_156679	133	37	the	the	DT
10_1101-2020_06_17_156679	133	38	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	133	39	active	active	JJ
10_1101-2020_06_17_156679	133	40	site	site	NN
10_1101-2020_06_17_156679	133	41	.	.	.
10_1101-2020_06_17_156679	134	1	In	in	IN
10_1101-2020_06_17_156679	134	2	contrast	contrast	NN
10_1101-2020_06_17_156679	134	3	,	,	,
10_1101-2020_06_17_156679	134	4	fragments	fragment	NNS
10_1101-2020_06_17_156679	134	5	showing	show	VBG
10_1101-2020_06_17_156679	134	6	very	very	RB
10_1101-2020_06_17_156679	134	7	little	little	JJ
10_1101-2020_06_17_156679	134	8	STD	STD	NNP
10_1101-2020_06_17_156679	134	9	NMR	NMR	NNP
10_1101-2020_06_17_156679	134	10	signal	signal	NN
10_1101-2020_06_17_156679	134	11	255	255	CD
10_1101-2020_06_17_156679	134	12	.CC	.CC	,
10_1101-2020_06_17_156679	134	13	-	-	:
10_1101-2020_06_17_156679	134	14	BY	by	IN
10_1101-2020_06_17_156679	134	15	4.0	4.0	CD
10_1101-2020_06_17_156679	134	16	International	International	NNP
10_1101-2020_06_17_156679	134	17	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	134	18	under	under	IN
10_1101-2020_06_17_156679	134	19	a	a	DT
10_1101-2020_06_17_156679	134	20	(	(	-LRB-
10_1101-2020_06_17_156679	134	21	which	which	WDT
10_1101-2020_06_17_156679	134	22	was	be	VBD
10_1101-2020_06_17_156679	134	23	not	not	RB
10_1101-2020_06_17_156679	134	24	certified	certify	VBN
10_1101-2020_06_17_156679	134	25	by	by	IN
10_1101-2020_06_17_156679	134	26	peer	peer	NN
10_1101-2020_06_17_156679	134	27	review	review	NN
10_1101-2020_06_17_156679	134	28	)	)	-RRB-
10_1101-2020_06_17_156679	134	29	is	be	VBZ
10_1101-2020_06_17_156679	134	30	the	the	DT
10_1101-2020_06_17_156679	134	31	author	author	NN
10_1101-2020_06_17_156679	134	32	/	/	SYM
10_1101-2020_06_17_156679	134	33	funder	funder	NN
10_1101-2020_06_17_156679	134	34	,	,	,
10_1101-2020_06_17_156679	134	35	who	who	WP
10_1101-2020_06_17_156679	134	36	has	have	VBZ
10_1101-2020_06_17_156679	134	37	granted	grant	VBN
10_1101-2020_06_17_156679	134	38	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	134	39	a	a	DT
10_1101-2020_06_17_156679	134	40	license	license	NN
10_1101-2020_06_17_156679	134	41	to	to	TO
10_1101-2020_06_17_156679	134	42	display	display	VB
10_1101-2020_06_17_156679	134	43	the	the	DT
10_1101-2020_06_17_156679	134	44	preprint	preprint	NN
10_1101-2020_06_17_156679	134	45	in	in	IN
10_1101-2020_06_17_156679	134	46	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	134	47	.	.	.
10_1101-2020_06_17_156679	135	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	135	2	is	be	VBZ
10_1101-2020_06_17_156679	135	3	made	make	VBN
10_1101-2020_06_17_156679	135	4	The	the	DT
10_1101-2020_06_17_156679	135	5	copyright	copyright	NN
10_1101-2020_06_17_156679	135	6	holder	holder	NN
10_1101-2020_06_17_156679	135	7	for	for	IN
10_1101-2020_06_17_156679	135	8	this	this	DT
10_1101-2020_06_17_156679	135	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	135	10	version	version	NN
10_1101-2020_06_17_156679	135	11	posted	post	VBD
10_1101-2020_06_17_156679	135	12	January	January	NNP
10_1101-2020_06_17_156679	135	13	6	6	CD
10_1101-2020_06_17_156679	135	14	,	,	,
10_1101-2020_06_17_156679	135	15	2021	2021	CD
10_1101-2020_06_17_156679	135	16	.	.	.
10_1101-2020_06_17_156679	135	17	;	;	:
10_1101-2020_06_17_156679	135	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	135	19	:	:	:
10_1101-2020_06_17_156679	135	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	135	21	preprint	preprint	NN
10_1101-2020_06_17_156679	135	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	135	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	135	24	10	10	CD
10_1101-2020_06_17_156679	135	25	(	(	-LRB-
10_1101-2020_06_17_156679	135	26	x0397	x0397	NNP
10_1101-2020_06_17_156679	135	27	and	and	CC
10_1101-2020_06_17_156679	135	28	x0387	x0387	NNP
10_1101-2020_06_17_156679	135	29	,	,	,
10_1101-2020_06_17_156679	135	30	Fig	Fig	NNP
10_1101-2020_06_17_156679	135	31	.	.	.
10_1101-2020_06_17_156679	136	1	S3E	S3E	NNP
10_1101-2020_06_17_156679	136	2	,	,	,
10_1101-2020_06_17_156679	136	3	F	F	NNP
10_1101-2020_06_17_156679	136	4	,	,	,
10_1101-2020_06_17_156679	136	5	and	and	CC
10_1101-2020_06_17_156679	136	6	Movies	Movies	NNP
10_1101-2020_06_17_156679	136	7	S5	S5	NNP
10_1101-2020_06_17_156679	136	8	and	and	CC
10_1101-2020_06_17_156679	136	9	S6	s6	NN
10_1101-2020_06_17_156679	136	10	)	)	-RRB-
10_1101-2020_06_17_156679	136	11	regularly	regularly	RB
10_1101-2020_06_17_156679	136	12	exit	exit	VBP
10_1101-2020_06_17_156679	136	13	the	the	DT
10_1101-2020_06_17_156679	136	14	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	136	15	active	active	JJ
10_1101-2020_06_17_156679	136	16	site	site	NN
10_1101-2020_06_17_156679	136	17	and	and	CC
10_1101-2020_06_17_156679	136	18	show	show	VBP
10_1101-2020_06_17_156679	136	19	256	256	CD
10_1101-2020_06_17_156679	136	20	average	average	JJ
10_1101-2020_06_17_156679	136	21	RMSDs	rmsd	NNS
10_1101-2020_06_17_156679	136	22	in	in	IN
10_1101-2020_06_17_156679	136	23	excess	excess	NN
10_1101-2020_06_17_156679	136	24	of	of	IN
10_1101-2020_06_17_156679	136	25	15	15	CD
10_1101-2020_06_17_156679	136	26	Å	å	NN
10_1101-2020_06_17_156679	136	27	with	with	IN
10_1101-2020_06_17_156679	136	28	very	very	RB
10_1101-2020_06_17_156679	136	29	limited	limited	JJ
10_1101-2020_06_17_156679	136	30	stability	stability	NN
10_1101-2020_06_17_156679	136	31	.	.	.
10_1101-2020_06_17_156679	137	1	Combining	combine	VBG
10_1101-2020_06_17_156679	137	2	the	the	DT
10_1101-2020_06_17_156679	137	3	quantitative	quantitative	JJ
10_1101-2020_06_17_156679	137	4	Kd	Kd	NNP
10_1101-2020_06_17_156679	137	5	and	and	CC
10_1101-2020_06_17_156679	137	6	MD	MD	NNP
10_1101-2020_06_17_156679	137	7	257	257	CD
10_1101-2020_06_17_156679	137	8	information	information	NN
10_1101-2020_06_17_156679	137	9	above	above	RB
10_1101-2020_06_17_156679	137	10	,	,	,
10_1101-2020_06_17_156679	137	11	we	-PRON-	PRP
10_1101-2020_06_17_156679	137	12	surmised	surmise	VBD
10_1101-2020_06_17_156679	137	13	that	that	IN
10_1101-2020_06_17_156679	137	14	,	,	,
10_1101-2020_06_17_156679	137	15	despite	despite	IN
10_1101-2020_06_17_156679	137	16	limitations	limitation	NNS
10_1101-2020_06_17_156679	137	17	inherent	inherent	JJ
10_1101-2020_06_17_156679	137	18	in	in	IN
10_1101-2020_06_17_156679	137	19	this	this	DT
10_1101-2020_06_17_156679	137	20	type	type	NN
10_1101-2020_06_17_156679	137	21	of	of	IN
10_1101-2020_06_17_156679	137	22	analysis	analysis	NN
10_1101-2020_06_17_156679	137	23	and	and	CC
10_1101-2020_06_17_156679	137	24	258	258	CD
10_1101-2020_06_17_156679	137	25	uncertainties	uncertainty	NNS
10_1101-2020_06_17_156679	137	26	in	in	IN
10_1101-2020_06_17_156679	137	27	ligand	ligand	NNP
10_1101-2020_06_17_156679	137	28	amounts	amount	NNS
10_1101-2020_06_17_156679	137	29	,	,	,
10_1101-2020_06_17_156679	137	30	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	137	31	values	value	NNS
10_1101-2020_06_17_156679	137	32	recorded	record	VBN
10_1101-2020_06_17_156679	137	33	at	at	IN
10_1101-2020_06_17_156679	137	34	single	single	JJ
10_1101-2020_06_17_156679	137	35	compound	compound	NN
10_1101-2020_06_17_156679	137	36	concentration	concentration	NN
10_1101-2020_06_17_156679	137	37	can	can	MD
10_1101-2020_06_17_156679	137	38	act	act	VB
10_1101-2020_06_17_156679	137	39	259	259	CD
10_1101-2020_06_17_156679	137	40	as	as	IN
10_1101-2020_06_17_156679	137	41	proxy	proxy	JJ
10_1101-2020_06_17_156679	137	42	measurements	measurement	NNS
10_1101-2020_06_17_156679	137	43	of	of	IN
10_1101-2020_06_17_156679	137	44	Mpro	mpro	JJ
10_1101-2020_06_17_156679	137	45	affinity	affinity	NN
10_1101-2020_06_17_156679	137	46	for	for	IN
10_1101-2020_06_17_156679	137	47	ligands	ligand	NNS
10_1101-2020_06_17_156679	137	48	.	.	.
10_1101-2020_06_17_156679	138	1	260	260	CD
10_1101-2020_06_17_156679	138	2	261	261	CD
10_1101-2020_06_17_156679	138	3	Assessment	Assessment	NNP
10_1101-2020_06_17_156679	138	4	of	of	IN
10_1101-2020_06_17_156679	138	5	M	M	NNP
10_1101-2020_06_17_156679	138	6	pro	pro	NN
10_1101-2020_06_17_156679	138	7	binding	binding	JJ
10_1101-2020_06_17_156679	138	8	by	by	IN
10_1101-2020_06_17_156679	138	9	COVID	COVID	NNP
10_1101-2020_06_17_156679	138	10	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	138	11	ligands	ligand	VBZ
10_1101-2020_06_17_156679	138	12	262	262	CD
10_1101-2020_06_17_156679	138	13	We	-PRON-	PRP
10_1101-2020_06_17_156679	138	14	proceeded	proceed	VBD
10_1101-2020_06_17_156679	138	15	to	to	TO
10_1101-2020_06_17_156679	138	16	characterise	characterise	VB
10_1101-2020_06_17_156679	138	17	by	by	IN
10_1101-2020_06_17_156679	138	18	STD	STD	NNP
10_1101-2020_06_17_156679	138	19	-	-	HYPH
10_1101-2020_06_17_156679	138	20	NMR	NMR	NNP
10_1101-2020_06_17_156679	138	21	the	the	DT
10_1101-2020_06_17_156679	138	22	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	138	23	binding	bind	VBG
10_1101-2020_06_17_156679	138	24	of	of	IN
10_1101-2020_06_17_156679	138	25	bespoke	bespoke	NN
10_1101-2020_06_17_156679	138	26	ligands	ligand	NNS
10_1101-2020_06_17_156679	138	27	created	create	VBN
10_1101-2020_06_17_156679	138	28	as	as	IN
10_1101-2020_06_17_156679	138	29	part	part	NN
10_1101-2020_06_17_156679	138	30	of	of	IN
10_1101-2020_06_17_156679	138	31	263	263	CD
10_1101-2020_06_17_156679	138	32	the	the	DT
10_1101-2020_06_17_156679	138	33	COVID	COVID	NNP
10_1101-2020_06_17_156679	138	34	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	138	35	project	project	NN
10_1101-2020_06_17_156679	138	36	and	and	CC
10_1101-2020_06_17_156679	138	37	designed	design	VBN
10_1101-2020_06_17_156679	138	38	to	to	TO
10_1101-2020_06_17_156679	138	39	act	act	VB
10_1101-2020_06_17_156679	138	40	as	as	IN
10_1101-2020_06_17_156679	138	41	non	non	JJ
10_1101-2020_06_17_156679	138	42	-	-	JJ
10_1101-2020_06_17_156679	138	43	covalent	covalent	JJ
10_1101-2020_06_17_156679	138	44	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	138	45	of	of	IN
10_1101-2020_06_17_156679	138	46	the	the	DT
10_1101-2020_06_17_156679	138	47	protease	protease	NN
10_1101-2020_06_17_156679	138	48	(	(	-LRB-
10_1101-2020_06_17_156679	138	49	17	17	CD
10_1101-2020_06_17_156679	138	50	)	)	-RRB-
10_1101-2020_06_17_156679	138	51	.	.	.
10_1101-2020_06_17_156679	139	1	264	264	CD
10_1101-2020_06_17_156679	139	2	Similar	similar	JJ
10_1101-2020_06_17_156679	139	3	to	to	IN
10_1101-2020_06_17_156679	139	4	the	the	DT
10_1101-2020_06_17_156679	139	5	assays	assay	NNS
10_1101-2020_06_17_156679	139	6	of	of	IN
10_1101-2020_06_17_156679	139	7	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	139	8	fragments	fragment	NNS
10_1101-2020_06_17_156679	139	9	above	above	RB
10_1101-2020_06_17_156679	139	10	,	,	,
10_1101-2020_06_17_156679	139	11	we	-PRON-	PRP
10_1101-2020_06_17_156679	139	12	focused	focus	VBD
10_1101-2020_06_17_156679	139	13	our	-PRON-	PRP$
10_1101-2020_06_17_156679	139	14	analysis	analysis	NN
10_1101-2020_06_17_156679	139	15	of	of	IN
10_1101-2020_06_17_156679	139	16	STD	STD	NNP
10_1101-2020_06_17_156679	139	17	signals	signal	NNS
10_1101-2020_06_17_156679	139	18	to	to	IN
10_1101-2020_06_17_156679	139	19	265	265	CD
10_1101-2020_06_17_156679	139	20	aromatic	aromatic	JJ
10_1101-2020_06_17_156679	139	21	moieties	moiety	NNS
10_1101-2020_06_17_156679	139	22	of	of	IN
10_1101-2020_06_17_156679	139	23	ligands	ligand	NNS
10_1101-2020_06_17_156679	139	24	binding	bind	VBG
10_1101-2020_06_17_156679	139	25	to	to	IN
10_1101-2020_06_17_156679	139	26	the	the	DT
10_1101-2020_06_17_156679	139	27	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	139	28	active	active	JJ
10_1101-2020_06_17_156679	139	29	side	side	NN
10_1101-2020_06_17_156679	139	30	and	and	CC
10_1101-2020_06_17_156679	139	31	extracted	extract	VBD
10_1101-2020_06_17_156679	139	32	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	139	33	values	value	NNS
10_1101-2020_06_17_156679	139	34	only	only	RB
10_1101-2020_06_17_156679	139	35	from	from	IN
10_1101-2020_06_17_156679	139	36	266	266	CD
10_1101-2020_06_17_156679	139	37	the	the	DT
10_1101-2020_06_17_156679	139	38	strongest	strong	JJS
10_1101-2020_06_17_156679	139	39	STD	STD	NNP
10_1101-2020_06_17_156679	139	40	peaks	peak	NNS
10_1101-2020_06_17_156679	139	41	.	.	.
10_1101-2020_06_17_156679	140	1	Once	once	RB
10_1101-2020_06_17_156679	140	2	again	again	RB
10_1101-2020_06_17_156679	140	3	,	,	,
10_1101-2020_06_17_156679	140	4	we	-PRON-	PRP
10_1101-2020_06_17_156679	140	5	noted	note	VBD
10_1101-2020_06_17_156679	140	6	substantial	substantial	JJ
10_1101-2020_06_17_156679	140	7	differences	difference	NNS
10_1101-2020_06_17_156679	140	8	in	in	IN
10_1101-2020_06_17_156679	140	9	apparent	apparent	JJ
10_1101-2020_06_17_156679	140	10	compound	compound	NN
10_1101-2020_06_17_156679	140	11	267	267	CD
10_1101-2020_06_17_156679	140	12	concentrations	concentration	NNS
10_1101-2020_06_17_156679	140	13	,	,	,
10_1101-2020_06_17_156679	140	14	judging	judge	VBG
10_1101-2020_06_17_156679	140	15	from	from	IN
10_1101-2020_06_17_156679	140	16	reference	reference	NN
10_1101-2020_06_17_156679	140	17	1H	1H	VBN
10_1101-2020_06_17_156679	140	18	spectral	spectral	JJ
10_1101-2020_06_17_156679	140	19	intensities	intensity	NNS
10_1101-2020_06_17_156679	140	20	(	(	-LRB-
10_1101-2020_06_17_156679	140	21	Fig	fig	NN
10_1101-2020_06_17_156679	140	22	.	.	.
10_1101-2020_06_17_156679	141	1	3A	3A	NNP
10_1101-2020_06_17_156679	141	2	)	)	-RRB-
10_1101-2020_06_17_156679	141	3	,	,	,
10_1101-2020_06_17_156679	141	4	which	which	WDT
10_1101-2020_06_17_156679	141	5	could	could	MD
10_1101-2020_06_17_156679	141	6	not	not	RB
10_1101-2020_06_17_156679	141	7	be	be	VB
10_1101-2020_06_17_156679	141	8	268	268	CD
10_1101-2020_06_17_156679	141	9	attributed	attribute	VBN
10_1101-2020_06_17_156679	141	10	to	to	IN
10_1101-2020_06_17_156679	141	11	errors	error	NNS
10_1101-2020_06_17_156679	141	12	in	in	IN
10_1101-2020_06_17_156679	141	13	sample	sample	NN
10_1101-2020_06_17_156679	141	14	preparation	preparation	NN
10_1101-2020_06_17_156679	141	15	as	as	IN
10_1101-2020_06_17_156679	141	16	the	the	DT
10_1101-2020_06_17_156679	141	17	standard	standard	JJ
10_1101-2020_06_17_156679	141	18	deviation	deviation	NN
10_1101-2020_06_17_156679	141	19	of	of	IN
10_1101-2020_06_17_156679	141	20	residual	residual	JJ
10_1101-2020_06_17_156679	141	21	1H	1h	JJ
10_1101-2020_06_17_156679	141	22	intensity	intensity	NN
10_1101-2020_06_17_156679	141	23	in	in	IN
10_1101-2020_06_17_156679	141	24	the	the	DT
10_1101-2020_06_17_156679	141	25	269	269	CD
10_1101-2020_06_17_156679	141	26	D6-DMSO	D6-DMSO	NNP
10_1101-2020_06_17_156679	141	27	peak	peak	NN
10_1101-2020_06_17_156679	141	28	did	do	VBD
10_1101-2020_06_17_156679	141	29	not	not	RB
10_1101-2020_06_17_156679	141	30	exceed	exceed	VB
10_1101-2020_06_17_156679	141	31	5	5	CD
10_1101-2020_06_17_156679	141	32	%	%	NN
10_1101-2020_06_17_156679	141	33	in	in	IN
10_1101-2020_06_17_156679	141	34	any	any	DT
10_1101-2020_06_17_156679	141	35	of	of	IN
10_1101-2020_06_17_156679	141	36	the	the	DT
10_1101-2020_06_17_156679	141	37	ligand	ligand	NN
10_1101-2020_06_17_156679	141	38	batches	batch	NNS
10_1101-2020_06_17_156679	141	39	tested	test	VBN
10_1101-2020_06_17_156679	141	40	.	.	.
10_1101-2020_06_17_156679	142	1	Crucially	crucially	RB
10_1101-2020_06_17_156679	142	2	,	,	,
10_1101-2020_06_17_156679	142	3	out	out	IN
10_1101-2020_06_17_156679	142	4	of	of	IN
10_1101-2020_06_17_156679	142	5	650	650	CD
10_1101-2020_06_17_156679	142	6	different	different	JJ
10_1101-2020_06_17_156679	142	7	270	270	CD
10_1101-2020_06_17_156679	142	8	molecules	molecule	NNS
10_1101-2020_06_17_156679	142	9	tested	test	VBN
10_1101-2020_06_17_156679	142	10	,	,	,
10_1101-2020_06_17_156679	142	11	samples	sample	NNS
10_1101-2020_06_17_156679	142	12	of	of	IN
10_1101-2020_06_17_156679	142	13	35	35	CD
10_1101-2020_06_17_156679	142	14	compounds	compound	NNS
10_1101-2020_06_17_156679	142	15	(	(	-LRB-
10_1101-2020_06_17_156679	142	16	7.6	7.6	CD
10_1101-2020_06_17_156679	142	17	%	%	NN
10_1101-2020_06_17_156679	142	18	)	)	-RRB-
10_1101-2020_06_17_156679	142	19	contained	contain	VBD
10_1101-2020_06_17_156679	142	20	no	no	DT
10_1101-2020_06_17_156679	142	21	ligand	ligand	NN
10_1101-2020_06_17_156679	142	22	and	and	CC
10_1101-2020_06_17_156679	142	23	86	86	CD
10_1101-2020_06_17_156679	142	24	(	(	-LRB-
10_1101-2020_06_17_156679	142	25	13.2	13.2	CD
10_1101-2020_06_17_156679	142	26	%	%	NN
10_1101-2020_06_17_156679	142	27	)	)	-RRB-
10_1101-2020_06_17_156679	142	28	very	very	RB
10_1101-2020_06_17_156679	142	29	little	little	JJ
10_1101-2020_06_17_156679	142	30	271	271	CD
10_1101-2020_06_17_156679	142	31	ligand	ligand	NN
10_1101-2020_06_17_156679	142	32	(	(	-LRB-
10_1101-2020_06_17_156679	142	33	Fig	fig	NN
10_1101-2020_06_17_156679	142	34	.	.	.
10_1101-2020_06_17_156679	143	1	3A	3A	NNP
10_1101-2020_06_17_156679	143	2	)	)	-RRB-
10_1101-2020_06_17_156679	143	3	.	.	.
10_1101-2020_06_17_156679	144	1	In	in	IN
10_1101-2020_06_17_156679	144	2	these	these	DT
10_1101-2020_06_17_156679	144	3	cases	case	NNS
10_1101-2020_06_17_156679	144	4	,	,	,
10_1101-2020_06_17_156679	144	5	NMR	NMR	NNP
10_1101-2020_06_17_156679	144	6	assays	assay	NNS
10_1101-2020_06_17_156679	144	7	were	be	VBD
10_1101-2020_06_17_156679	144	8	repeated	repeat	VBN
10_1101-2020_06_17_156679	144	9	using	use	VBG
10_1101-2020_06_17_156679	144	10	a	a	DT
10_1101-2020_06_17_156679	144	11	separate	separate	JJ
10_1101-2020_06_17_156679	144	12	batch	batch	NN
10_1101-2020_06_17_156679	144	13	of	of	IN
10_1101-2020_06_17_156679	144	14	compound	compound	NN
10_1101-2020_06_17_156679	144	15	;	;	:
10_1101-2020_06_17_156679	144	16	272	272	CD
10_1101-2020_06_17_156679	144	17	however	however	RB
10_1101-2020_06_17_156679	144	18	,	,	,
10_1101-2020_06_17_156679	144	19	96.2	96.2	CD
10_1101-2020_06_17_156679	144	20	%	%	NN
10_1101-2020_06_17_156679	144	21	of	of	IN
10_1101-2020_06_17_156679	144	22	repeat	repeat	NN
10_1101-2020_06_17_156679	144	23	experiments	experiment	NNS
10_1101-2020_06_17_156679	144	24	yielded	yield	VBD
10_1101-2020_06_17_156679	144	25	the	the	DT
10_1101-2020_06_17_156679	144	26	same	same	JJ
10_1101-2020_06_17_156679	144	27	outcome	outcome	NN
10_1101-2020_06_17_156679	144	28	of	of	IN
10_1101-2020_06_17_156679	144	29	no	no	DT
10_1101-2020_06_17_156679	144	30	or	or	CC
10_1101-2020_06_17_156679	144	31	very	very	RB
10_1101-2020_06_17_156679	144	32	little	little	JJ
10_1101-2020_06_17_156679	144	33	ligand	ligand	NN
10_1101-2020_06_17_156679	144	34	in	in	IN
10_1101-2020_06_17_156679	144	35	the	the	DT
10_1101-2020_06_17_156679	144	36	273	273	CD
10_1101-2020_06_17_156679	144	37	NMR	NMR	NNP
10_1101-2020_06_17_156679	144	38	samples	sample	NNS
10_1101-2020_06_17_156679	144	39	.	.	.
10_1101-2020_06_17_156679	145	1	274	274	CD
10_1101-2020_06_17_156679	145	2	We	-PRON-	PRP
10_1101-2020_06_17_156679	145	3	measured	measure	VBD
10_1101-2020_06_17_156679	145	4	STDratio	stdratio	NN
10_1101-2020_06_17_156679	145	5	values	value	NNS
10_1101-2020_06_17_156679	145	6	from	from	IN
10_1101-2020_06_17_156679	145	7	samples	sample	NNS
10_1101-2020_06_17_156679	145	8	were	be	VBD
10_1101-2020_06_17_156679	145	9	ligands	ligand	NNS
10_1101-2020_06_17_156679	145	10	produced	produce	VBN
10_1101-2020_06_17_156679	145	11	sufficiently	sufficiently	RB
10_1101-2020_06_17_156679	145	12	strong	strong	JJ
10_1101-2020_06_17_156679	145	13	reference	reference	NN
10_1101-2020_06_17_156679	145	14	1H	1h	CD
10_1101-2020_06_17_156679	145	15	275	275	CD
10_1101-2020_06_17_156679	145	16	NMR	NMR	NNP
10_1101-2020_06_17_156679	145	17	spectra	spectra	NNP
10_1101-2020_06_17_156679	145	18	to	to	TO
10_1101-2020_06_17_156679	145	19	be	be	VB
10_1101-2020_06_17_156679	145	20	readily	readily	RB
10_1101-2020_06_17_156679	145	21	visible	visible	JJ
10_1101-2020_06_17_156679	145	22	,	,	,
10_1101-2020_06_17_156679	145	23	and	and	CC
10_1101-2020_06_17_156679	145	24	deposited	deposit	VBD
10_1101-2020_06_17_156679	145	25	these	these	DT
10_1101-2020_06_17_156679	145	26	values	value	NNS
10_1101-2020_06_17_156679	145	27	and	and	CC
10_1101-2020_06_17_156679	145	28	associated	associate	VBN
10_1101-2020_06_17_156679	145	29	raw	raw	JJ
10_1101-2020_06_17_156679	145	30	NMR	NMR	NNP
10_1101-2020_06_17_156679	145	31	data	datum	NNS
10_1101-2020_06_17_156679	145	32	to	to	IN
10_1101-2020_06_17_156679	145	33	the	the	DT
10_1101-2020_06_17_156679	145	34	276	276	CD
10_1101-2020_06_17_156679	145	35	Collaborative	Collaborative	NNP
10_1101-2020_06_17_156679	145	36	Drug	Drug	NNP
10_1101-2020_06_17_156679	145	37	Discovery	Discovery	NNP
10_1101-2020_06_17_156679	145	38	database	database	NN
10_1101-2020_06_17_156679	145	39	(	(	-LRB-
10_1101-2020_06_17_156679	145	40	33	33	CD
10_1101-2020_06_17_156679	145	41	)	)	-RRB-
10_1101-2020_06_17_156679	145	42	.	.	.
10_1101-2020_06_17_156679	146	1	Some	some	DT
10_1101-2020_06_17_156679	146	2	of	of	IN
10_1101-2020_06_17_156679	146	3	these	these	DT
10_1101-2020_06_17_156679	146	4	ligands	ligand	NNS
10_1101-2020_06_17_156679	146	5	were	be	VBD
10_1101-2020_06_17_156679	146	6	assessed	assess	VBN
10_1101-2020_06_17_156679	146	7	independently	independently	RB
10_1101-2020_06_17_156679	146	8	for	for	IN
10_1101-2020_06_17_156679	146	9	277	277	CD
10_1101-2020_06_17_156679	146	10	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	146	11	inhibition	inhibition	NN
10_1101-2020_06_17_156679	146	12	of	of	IN
10_1101-2020_06_17_156679	146	13	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	146	14	using	use	VBG
10_1101-2020_06_17_156679	146	15	a	a	DT
10_1101-2020_06_17_156679	146	16	mass	mass	NN
10_1101-2020_06_17_156679	146	17	spectroscopy	spectroscopy	NN
10_1101-2020_06_17_156679	146	18	method	method	NN
10_1101-2020_06_17_156679	146	19	as	as	IN
10_1101-2020_06_17_156679	146	20	part	part	NN
10_1101-2020_06_17_156679	146	21	of	of	IN
10_1101-2020_06_17_156679	146	22	the	the	DT
10_1101-2020_06_17_156679	146	23	COVID	COVID	NNP
10_1101-2020_06_17_156679	146	24	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	146	25	278	278	CD
10_1101-2020_06_17_156679	146	26	collaboration	collaboration	NN
10_1101-2020_06_17_156679	146	27	(	(	-LRB-
10_1101-2020_06_17_156679	146	28	17	17	CD
10_1101-2020_06_17_156679	146	29	)	)	-RRB-
10_1101-2020_06_17_156679	146	30	.	.	.
10_1101-2020_06_17_156679	147	1	Where	where	WRB
10_1101-2020_06_17_156679	147	2	both	both	DT
10_1101-2020_06_17_156679	147	3	parameters	parameter	NNS
10_1101-2020_06_17_156679	147	4	are	be	VBP
10_1101-2020_06_17_156679	147	5	available	available	JJ
10_1101-2020_06_17_156679	147	6	,	,	,
10_1101-2020_06_17_156679	147	7	we	-PRON-	PRP
10_1101-2020_06_17_156679	147	8	compared	compare	VBD
10_1101-2020_06_17_156679	147	9	the	the	DT
10_1101-2020_06_17_156679	147	10	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	147	11	values	value	NNS
10_1101-2020_06_17_156679	147	12	and	and	CC
10_1101-2020_06_17_156679	147	13	50	50	CD
10_1101-2020_06_17_156679	147	14	%	%	NN
10_1101-2020_06_17_156679	147	15	279	279	CD
10_1101-2020_06_17_156679	147	16	inhibition	inhibition	NN
10_1101-2020_06_17_156679	147	17	concentrations	concentration	NNS
10_1101-2020_06_17_156679	147	18	(	(	-LRB-
10_1101-2020_06_17_156679	147	19	IC50	IC50	NNP
10_1101-2020_06_17_156679	147	20	)	)	-RRB-
10_1101-2020_06_17_156679	147	21	of	of	IN
10_1101-2020_06_17_156679	147	22	these	these	DT
10_1101-2020_06_17_156679	147	23	ligands	ligand	NNS
10_1101-2020_06_17_156679	147	24	.	.	.
10_1101-2020_06_17_156679	148	1	As	as	IN
10_1101-2020_06_17_156679	148	2	shown	show	VBN
10_1101-2020_06_17_156679	148	3	in	in	IN
10_1101-2020_06_17_156679	148	4	Fig	Fig	NNP
10_1101-2020_06_17_156679	148	5	.	.	.
10_1101-2020_06_17_156679	149	1	3B	3B	NNP
10_1101-2020_06_17_156679	149	2	,	,	,
10_1101-2020_06_17_156679	149	3	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	149	4	and	and	CC
10_1101-2020_06_17_156679	149	5	IC50	IC50	NNP
10_1101-2020_06_17_156679	149	6	values	value	NNS
10_1101-2020_06_17_156679	149	7	show	show	VBP
10_1101-2020_06_17_156679	149	8	280	280	CD
10_1101-2020_06_17_156679	149	9	weak	weak	JJ
10_1101-2020_06_17_156679	149	10	correlation	correlation	NN
10_1101-2020_06_17_156679	149	11	(	(	-LRB-
10_1101-2020_06_17_156679	149	12	R2=30	r2=30	NN
10_1101-2020_06_17_156679	149	13	%	%	NN
10_1101-2020_06_17_156679	149	14	)	)	-RRB-
10_1101-2020_06_17_156679	149	15	for	for	IN
10_1101-2020_06_17_156679	149	16	most	most	JJS
10_1101-2020_06_17_156679	149	17	ligands	ligand	NNS
10_1101-2020_06_17_156679	149	18	tested	test	VBN
10_1101-2020_06_17_156679	149	19	;	;	:
10_1101-2020_06_17_156679	149	20	however	however	RB
10_1101-2020_06_17_156679	149	21	,	,	,
10_1101-2020_06_17_156679	149	22	a	a	DT
10_1101-2020_06_17_156679	149	23	subset	subset	NN
10_1101-2020_06_17_156679	149	24	of	of	IN
10_1101-2020_06_17_156679	149	25	ligands	ligand	NNS
10_1101-2020_06_17_156679	149	26	displayed	display	VBN
10_1101-2020_06_17_156679	149	27	281	281	CD
10_1101-2020_06_17_156679	149	28	conspicuously	conspicuously	RB
10_1101-2020_06_17_156679	149	29	low	low	JJ
10_1101-2020_06_17_156679	149	30	or	or	CC
10_1101-2020_06_17_156679	149	31	even	even	RB
10_1101-2020_06_17_156679	149	32	no	no	DT
10_1101-2020_06_17_156679	149	33	STD	STD	NNP
10_1101-2020_06_17_156679	149	34	signals	signal	NNS
10_1101-2020_06_17_156679	149	35	considering	consider	VBG
10_1101-2020_06_17_156679	149	36	their	-PRON-	PRP$
10_1101-2020_06_17_156679	149	37	effect	effect	NN
10_1101-2020_06_17_156679	149	38	on	on	IN
10_1101-2020_06_17_156679	149	39	Mpro	mpro	JJ
10_1101-2020_06_17_156679	149	40	activity	activity	NN
10_1101-2020_06_17_156679	149	41	,	,	,
10_1101-2020_06_17_156679	149	42	and	and	CC
10_1101-2020_06_17_156679	149	43	presented	present	VBD
10_1101-2020_06_17_156679	149	44	282	282	CD
10_1101-2020_06_17_156679	149	45	themselves	-PRON-	PRP
10_1101-2020_06_17_156679	149	46	as	as	IN
10_1101-2020_06_17_156679	149	47	outliers	outlier	NNS
10_1101-2020_06_17_156679	149	48	in	in	IN
10_1101-2020_06_17_156679	149	49	the	the	DT
10_1101-2020_06_17_156679	149	50	correlation	correlation	NN
10_1101-2020_06_17_156679	149	51	graph	graph	NN
10_1101-2020_06_17_156679	149	52	.	.	.
10_1101-2020_06_17_156679	150	1	As	as	IN
10_1101-2020_06_17_156679	150	2	these	these	DT
10_1101-2020_06_17_156679	150	3	outlier	outli	JJR
10_1101-2020_06_17_156679	150	4	ligands	ligand	VBZ
10_1101-2020_06_17_156679	150	5	had	have	VBD
10_1101-2020_06_17_156679	150	6	IC50	IC50	NNP
10_1101-2020_06_17_156679	150	7	values	value	NNS
10_1101-2020_06_17_156679	150	8	below	below	IN
10_1101-2020_06_17_156679	150	9	10	10	CD
10_1101-2020_06_17_156679	150	10	μM	μM	NNS
10_1101-2020_06_17_156679	150	11	,	,	,
10_1101-2020_06_17_156679	150	12	283	283	CD
10_1101-2020_06_17_156679	150	13	suggesting	suggest	VBG
10_1101-2020_06_17_156679	150	14	that	that	IN
10_1101-2020_06_17_156679	150	15	their	-PRON-	PRP$
10_1101-2020_06_17_156679	150	16	affinities	affinity	NNS
10_1101-2020_06_17_156679	150	17	to	to	IN
10_1101-2020_06_17_156679	150	18	the	the	DT
10_1101-2020_06_17_156679	150	19	protease	protease	NN
10_1101-2020_06_17_156679	150	20	may	may	MD
10_1101-2020_06_17_156679	150	21	be	be	VB
10_1101-2020_06_17_156679	150	22	in	in	IN
10_1101-2020_06_17_156679	150	23	the	the	DT
10_1101-2020_06_17_156679	150	24	μM	μM	.
10_1101-2020_06_17_156679	150	25	Kd	Kd	NNP
10_1101-2020_06_17_156679	150	26	region	region	NN
10_1101-2020_06_17_156679	150	27	,	,	,
10_1101-2020_06_17_156679	150	28	we	-PRON-	PRP
10_1101-2020_06_17_156679	150	29	considered	consider	VBD
10_1101-2020_06_17_156679	150	30	whether	whether	IN
10_1101-2020_06_17_156679	150	31	284	284	CD
10_1101-2020_06_17_156679	150	32	our	-PRON-	PRP$
10_1101-2020_06_17_156679	150	33	approach	approach	NN
10_1101-2020_06_17_156679	150	34	gives	give	VBZ
10_1101-2020_06_17_156679	150	35	rise	rise	NN
10_1101-2020_06_17_156679	150	36	to	to	IN
10_1101-2020_06_17_156679	150	37	false	false	JJ
10_1101-2020_06_17_156679	150	38	-	-	HYPH
10_1101-2020_06_17_156679	150	39	negative	negative	JJ
10_1101-2020_06_17_156679	150	40	STD	STD	NNP
10_1101-2020_06_17_156679	150	41	results	result	NNS
10_1101-2020_06_17_156679	150	42	,	,	,
10_1101-2020_06_17_156679	150	43	for	for	IN
10_1101-2020_06_17_156679	150	44	example	example	NN
10_1101-2020_06_17_156679	150	45	through	through	IN
10_1101-2020_06_17_156679	150	46	slow	slow	JJ
10_1101-2020_06_17_156679	150	47	ligand	ligand	NN
10_1101-2020_06_17_156679	150	48	dissociation	dissociation	NN
10_1101-2020_06_17_156679	150	49	285	285	CD
10_1101-2020_06_17_156679	150	50	from	from	IN
10_1101-2020_06_17_156679	150	51	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	150	52	.	.	.
10_1101-2020_06_17_156679	151	1	286	286	CD
10_1101-2020_06_17_156679	151	2	.CC	.CC	:
10_1101-2020_06_17_156679	151	3	-	-	:
10_1101-2020_06_17_156679	151	4	BY	by	IN
10_1101-2020_06_17_156679	151	5	4.0	4.0	CD
10_1101-2020_06_17_156679	151	6	International	International	NNP
10_1101-2020_06_17_156679	151	7	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	151	8	under	under	IN
10_1101-2020_06_17_156679	151	9	a	a	DT
10_1101-2020_06_17_156679	151	10	(	(	-LRB-
10_1101-2020_06_17_156679	151	11	which	which	WDT
10_1101-2020_06_17_156679	151	12	was	be	VBD
10_1101-2020_06_17_156679	151	13	not	not	RB
10_1101-2020_06_17_156679	151	14	certified	certify	VBN
10_1101-2020_06_17_156679	151	15	by	by	IN
10_1101-2020_06_17_156679	151	16	peer	peer	NN
10_1101-2020_06_17_156679	151	17	review	review	NN
10_1101-2020_06_17_156679	151	18	)	)	-RRB-
10_1101-2020_06_17_156679	151	19	is	be	VBZ
10_1101-2020_06_17_156679	151	20	the	the	DT
10_1101-2020_06_17_156679	151	21	author	author	NN
10_1101-2020_06_17_156679	151	22	/	/	SYM
10_1101-2020_06_17_156679	151	23	funder	funder	NN
10_1101-2020_06_17_156679	151	24	,	,	,
10_1101-2020_06_17_156679	151	25	who	who	WP
10_1101-2020_06_17_156679	151	26	has	have	VBZ
10_1101-2020_06_17_156679	151	27	granted	grant	VBN
10_1101-2020_06_17_156679	151	28	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	151	29	a	a	DT
10_1101-2020_06_17_156679	151	30	license	license	NN
10_1101-2020_06_17_156679	151	31	to	to	TO
10_1101-2020_06_17_156679	151	32	display	display	VB
10_1101-2020_06_17_156679	151	33	the	the	DT
10_1101-2020_06_17_156679	151	34	preprint	preprint	NN
10_1101-2020_06_17_156679	151	35	in	in	IN
10_1101-2020_06_17_156679	151	36	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	151	37	.	.	.
10_1101-2020_06_17_156679	152	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	152	2	is	be	VBZ
10_1101-2020_06_17_156679	152	3	made	make	VBN
10_1101-2020_06_17_156679	152	4	The	the	DT
10_1101-2020_06_17_156679	152	5	copyright	copyright	NN
10_1101-2020_06_17_156679	152	6	holder	holder	NN
10_1101-2020_06_17_156679	152	7	for	for	IN
10_1101-2020_06_17_156679	152	8	this	this	DT
10_1101-2020_06_17_156679	152	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	152	10	version	version	NN
10_1101-2020_06_17_156679	152	11	posted	post	VBD
10_1101-2020_06_17_156679	152	12	January	January	NNP
10_1101-2020_06_17_156679	152	13	6	6	CD
10_1101-2020_06_17_156679	152	14	,	,	,
10_1101-2020_06_17_156679	152	15	2021	2021	CD
10_1101-2020_06_17_156679	152	16	.	.	.
10_1101-2020_06_17_156679	152	17	;	;	:
10_1101-2020_06_17_156679	152	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	152	19	:	:	:
10_1101-2020_06_17_156679	152	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	152	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	152	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	152	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	152	24	11	11	CD
10_1101-2020_06_17_156679	152	25	To	to	TO
10_1101-2020_06_17_156679	152	26	address	address	VB
10_1101-2020_06_17_156679	152	27	this	this	DT
10_1101-2020_06_17_156679	152	28	question	question	NN
10_1101-2020_06_17_156679	152	29	,	,	,
10_1101-2020_06_17_156679	152	30	we	-PRON-	PRP
10_1101-2020_06_17_156679	152	31	derived	derive	VBD
10_1101-2020_06_17_156679	152	32	an	an	DT
10_1101-2020_06_17_156679	152	33	assay	assay	NN
10_1101-2020_06_17_156679	152	34	whereby	whereby	WRB
10_1101-2020_06_17_156679	152	35	the	the	DT
10_1101-2020_06_17_156679	152	36	bespoke	bespoke	NN
10_1101-2020_06_17_156679	152	37	,	,	,
10_1101-2020_06_17_156679	152	38	high	high	JJ
10_1101-2020_06_17_156679	152	39	-	-	HYPH
10_1101-2020_06_17_156679	152	40	affinity	affinity	NN
10_1101-2020_06_17_156679	152	41	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	152	42	inhibitor	inhibitor	NN
10_1101-2020_06_17_156679	152	43	287	287	CD
10_1101-2020_06_17_156679	152	44	would	would	MD
10_1101-2020_06_17_156679	152	45	outcompete	outcompete	VB
10_1101-2020_06_17_156679	152	46	a	a	DT
10_1101-2020_06_17_156679	152	47	lower	low	JJR
10_1101-2020_06_17_156679	152	48	-	-	HYPH
10_1101-2020_06_17_156679	152	49	affinity	affinity	NN
10_1101-2020_06_17_156679	152	50	ligand	ligand	NN
10_1101-2020_06_17_156679	152	51	known	know	VBN
10_1101-2020_06_17_156679	152	52	to	to	TO
10_1101-2020_06_17_156679	152	53	provide	provide	VB
10_1101-2020_06_17_156679	152	54	strong	strong	JJ
10_1101-2020_06_17_156679	152	55	STD	STD	NNP
10_1101-2020_06_17_156679	152	56	signal	signal	NN
10_1101-2020_06_17_156679	152	57	from	from	IN
10_1101-2020_06_17_156679	152	58	the	the	DT
10_1101-2020_06_17_156679	152	59	protease	protease	NN
10_1101-2020_06_17_156679	152	60	288	288	CD
10_1101-2020_06_17_156679	152	61	active	active	JJ
10_1101-2020_06_17_156679	152	62	site	site	NN
10_1101-2020_06_17_156679	152	63	.	.	.
10_1101-2020_06_17_156679	153	1	In	in	IN
10_1101-2020_06_17_156679	153	2	these	these	DT
10_1101-2020_06_17_156679	153	3	experiments	experiment	NNS
10_1101-2020_06_17_156679	153	4	the	the	DT
10_1101-2020_06_17_156679	153	5	lower	low	JJR
10_1101-2020_06_17_156679	153	6	-	-	HYPH
10_1101-2020_06_17_156679	153	7	affinity	affinity	NN
10_1101-2020_06_17_156679	153	8	ligand	ligand	NN
10_1101-2020_06_17_156679	153	9	would	would	MD
10_1101-2020_06_17_156679	153	10	act	act	VB
10_1101-2020_06_17_156679	153	11	as	as	IN
10_1101-2020_06_17_156679	153	12	‘	'	``
10_1101-2020_06_17_156679	153	13	spy	spy	NN
10_1101-2020_06_17_156679	153	14	’	'	''
10_1101-2020_06_17_156679	153	15	molecule	molecule	NN
10_1101-2020_06_17_156679	153	16	whose	whose	WP$
10_1101-2020_06_17_156679	153	17	STD	STD	NNP
10_1101-2020_06_17_156679	153	18	289	289	CD
10_1101-2020_06_17_156679	153	19	signal	signal	NN
10_1101-2020_06_17_156679	153	20	reduces	reduce	NNS
10_1101-2020_06_17_156679	153	21	as	as	IN
10_1101-2020_06_17_156679	153	22	function	function	NN
10_1101-2020_06_17_156679	153	23	of	of	IN
10_1101-2020_06_17_156679	153	24	inhibitor	inhibitor	NN
10_1101-2020_06_17_156679	153	25	concentration	concentration	NN
10_1101-2020_06_17_156679	153	26	.	.	.
10_1101-2020_06_17_156679	154	1	We	-PRON-	PRP
10_1101-2020_06_17_156679	154	2	used	use	VBD
10_1101-2020_06_17_156679	154	3	fragment	fragment	NN
10_1101-2020_06_17_156679	154	4	x0434	x0434	NN
10_1101-2020_06_17_156679	154	5	,	,	,
10_1101-2020_06_17_156679	154	6	which	which	WDT
10_1101-2020_06_17_156679	154	7	yields	yield	VBZ
10_1101-2020_06_17_156679	154	8	290	290	CD
10_1101-2020_06_17_156679	154	9	substantial	substantial	JJ
10_1101-2020_06_17_156679	154	10	STD	STD	NNP
10_1101-2020_06_17_156679	154	11	signal	signal	NN
10_1101-2020_06_17_156679	154	12	with	with	IN
10_1101-2020_06_17_156679	154	13	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	154	14	(	(	-LRB-
10_1101-2020_06_17_156679	154	15	Fig	fig	NN
10_1101-2020_06_17_156679	154	16	.	.	.
10_1101-2020_06_17_156679	155	1	1B	1B	NNP
10_1101-2020_06_17_156679	155	2	and	and	CC
10_1101-2020_06_17_156679	155	3	2A	2A	NNP
10_1101-2020_06_17_156679	155	4	)	)	-RRB-
10_1101-2020_06_17_156679	155	5	,	,	,
10_1101-2020_06_17_156679	155	6	as	as	IN
10_1101-2020_06_17_156679	155	7	‘	'	``
10_1101-2020_06_17_156679	155	8	spy	spy	NN
10_1101-2020_06_17_156679	155	9	’	'	''
10_1101-2020_06_17_156679	155	10	,	,	,
10_1101-2020_06_17_156679	155	11	and	and	CC
10_1101-2020_06_17_156679	155	12	tested	test	VBN
10_1101-2020_06_17_156679	155	13	protease	protease	NNP
10_1101-2020_06_17_156679	155	14	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	155	15	EDJ	EDJ	NNP
10_1101-2020_06_17_156679	155	16	-	-	HYPH
10_1101-2020_06_17_156679	155	17	MED-291	MED-291	NNP
10_1101-2020_06_17_156679	155	18	a364e151	a364e151	NNP
10_1101-2020_06_17_156679	155	19	-	-	HYPH
10_1101-2020_06_17_156679	155	20	1	1	CD
10_1101-2020_06_17_156679	155	21	,	,	,
10_1101-2020_06_17_156679	155	22	LON	LON	NNP
10_1101-2020_06_17_156679	155	23	-	-	HYPH
10_1101-2020_06_17_156679	155	24	WEI	WEI	NNP
10_1101-2020_06_17_156679	155	25	-	-	HYPH
10_1101-2020_06_17_156679	155	26	ff7b210a-5	ff7b210a-5	NNP
10_1101-2020_06_17_156679	155	27	,	,	,
10_1101-2020_06_17_156679	155	28	CHO	CHO	NNP
10_1101-2020_06_17_156679	155	29	-	-	HYPH
10_1101-2020_06_17_156679	155	30	MSK-6e55470f-14	MSK-6e55470f-14	NNP
10_1101-2020_06_17_156679	155	31	and	and	CC
10_1101-2020_06_17_156679	155	32	LOR	LOR	NNP
10_1101-2020_06_17_156679	155	33	-	-	HYPH
10_1101-2020_06_17_156679	155	34	NOR-30067bb9	NOR-30067bb9	NNP
10_1101-2020_06_17_156679	155	35	-	-	HYPH
10_1101-2020_06_17_156679	155	36	11	11	CD
10_1101-2020_06_17_156679	155	37	as	as	IN
10_1101-2020_06_17_156679	155	38	x0434	x0434	NNP
10_1101-2020_06_17_156679	155	39	292	292	CD
10_1101-2020_06_17_156679	155	40	competitors	competitor	NNS
10_1101-2020_06_17_156679	155	41	.	.	.
10_1101-2020_06_17_156679	156	1	Of	of	IN
10_1101-2020_06_17_156679	156	2	these	these	DT
10_1101-2020_06_17_156679	156	3	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	156	4	,	,	,
10_1101-2020_06_17_156679	156	5	EDJ	EDJ	NNP
10_1101-2020_06_17_156679	156	6	-	-	HYPH
10_1101-2020_06_17_156679	156	7	MED	MED	NNP
10_1101-2020_06_17_156679	156	8	-	-	HYPH
10_1101-2020_06_17_156679	156	9	a364e151	a364e151	NN
10_1101-2020_06_17_156679	156	10	-	-	HYPH
10_1101-2020_06_17_156679	156	11	1	1	CD
10_1101-2020_06_17_156679	156	12	gave	give	VBD
10_1101-2020_06_17_156679	156	13	rise	rise	NN
10_1101-2020_06_17_156679	156	14	to	to	IN
10_1101-2020_06_17_156679	156	15	substantial	substantial	JJ
10_1101-2020_06_17_156679	156	16	STD	STD	NNP
10_1101-2020_06_17_156679	156	17	signal	signal	NN
10_1101-2020_06_17_156679	156	18	in	in	IN
10_1101-2020_06_17_156679	156	19	earlier	early	JJR
10_1101-2020_06_17_156679	156	20	293	293	CD
10_1101-2020_06_17_156679	156	21	assays	assay	NNS
10_1101-2020_06_17_156679	156	22	,	,	,
10_1101-2020_06_17_156679	156	23	whereas	whereas	IN
10_1101-2020_06_17_156679	156	24	the	the	DT
10_1101-2020_06_17_156679	156	25	remaining	remain	VBG
10_1101-2020_06_17_156679	156	26	produced	produce	VBN
10_1101-2020_06_17_156679	156	27	little	little	JJ
10_1101-2020_06_17_156679	156	28	or	or	CC
10_1101-2020_06_17_156679	156	29	no	no	DT
10_1101-2020_06_17_156679	156	30	STD	STD	NNP
10_1101-2020_06_17_156679	156	31	signal	signal	NN
10_1101-2020_06_17_156679	156	32	;	;	:
10_1101-2020_06_17_156679	156	33	yet	yet	CC
10_1101-2020_06_17_156679	156	34	,	,	,
10_1101-2020_06_17_156679	156	35	all	all	DT
10_1101-2020_06_17_156679	156	36	four	four	CD
10_1101-2020_06_17_156679	156	37	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	156	38	were	be	VBD
10_1101-2020_06_17_156679	156	39	reported	report	VBN
10_1101-2020_06_17_156679	156	40	294	294	CD
10_1101-2020_06_17_156679	156	41	to	to	TO
10_1101-2020_06_17_156679	156	42	have	have	VB
10_1101-2020_06_17_156679	156	43	low	low	JJ
10_1101-2020_06_17_156679	156	44	-	-	HYPH
10_1101-2020_06_17_156679	156	45	μM	μm	NN
10_1101-2020_06_17_156679	156	46	or	or	CC
10_1101-2020_06_17_156679	156	47	sub	sub	NN
10_1101-2020_06_17_156679	156	48	-	-	HYPH
10_1101-2020_06_17_156679	156	49	μM	μM	NNP
10_1101-2020_06_17_156679	156	50	IC50	IC50	NNP
10_1101-2020_06_17_156679	156	51	values	value	NNS
10_1101-2020_06_17_156679	156	52	based	base	VBN
10_1101-2020_06_17_156679	156	53	on	on	IN
10_1101-2020_06_17_156679	156	54	M	M	NNP
10_1101-2020_06_17_156679	156	55	pro	pro	JJ
10_1101-2020_06_17_156679	156	56	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	156	57	assays	assay	NNS
10_1101-2020_06_17_156679	156	58	.	.	.
10_1101-2020_06_17_156679	157	1	In	in	IN
10_1101-2020_06_17_156679	157	2	these	these	DT
10_1101-2020_06_17_156679	157	3	competition	competition	NN
10_1101-2020_06_17_156679	157	4	295	295	CD
10_1101-2020_06_17_156679	157	5	experiments	experiment	NNS
10_1101-2020_06_17_156679	157	6	,	,	,
10_1101-2020_06_17_156679	157	7	both	both	CC
10_1101-2020_06_17_156679	157	8	EDJ	EDJ	NNP
10_1101-2020_06_17_156679	157	9	-	-	HYPH
10_1101-2020_06_17_156679	157	10	MED	MED	NNP
10_1101-2020_06_17_156679	157	11	-	-	HYPH
10_1101-2020_06_17_156679	157	12	a364e151	a364e151	NN
10_1101-2020_06_17_156679	157	13	-	-	HYPH
10_1101-2020_06_17_156679	157	14	1	1	CD
10_1101-2020_06_17_156679	157	15	and	and	CC
10_1101-2020_06_17_156679	157	16	LON	LON	NNP
10_1101-2020_06_17_156679	157	17	-	-	HYPH
10_1101-2020_06_17_156679	157	18	WEI	WEI	NNP
10_1101-2020_06_17_156679	157	19	-	-	HYPH
10_1101-2020_06_17_156679	157	20	ff7b210a-5	ff7b210a-5	NNP
10_1101-2020_06_17_156679	157	21	yielded	yield	VBD
10_1101-2020_06_17_156679	157	22	Kd	Kd	NNP
10_1101-2020_06_17_156679	157	23	parameters	parameter	NNS
10_1101-2020_06_17_156679	157	24	296	296	CD
10_1101-2020_06_17_156679	157	25	comparable	comparable	JJ
10_1101-2020_06_17_156679	157	26	to	to	IN
10_1101-2020_06_17_156679	157	27	the	the	DT
10_1101-2020_06_17_156679	157	28	reported	report	VBN
10_1101-2020_06_17_156679	157	29	IC50	IC50	NNP
10_1101-2020_06_17_156679	157	30	values	value	NNS
10_1101-2020_06_17_156679	157	31	(	(	-LRB-
10_1101-2020_06_17_156679	157	32	Fig	fig	NN
10_1101-2020_06_17_156679	157	33	.	.	.
10_1101-2020_06_17_156679	158	1	S5A	s5a	RB
10_1101-2020_06_17_156679	158	2	,	,	,
10_1101-2020_06_17_156679	158	3	B	b	NN
10_1101-2020_06_17_156679	158	4	)	)	-RRB-
10_1101-2020_06_17_156679	158	5	,	,	,
10_1101-2020_06_17_156679	158	6	showing	show	VBG
10_1101-2020_06_17_156679	158	7	that	that	IN
10_1101-2020_06_17_156679	158	8	at	at	IN
10_1101-2020_06_17_156679	158	9	least	least	JJS
10_1101-2020_06_17_156679	158	10	in	in	IN
10_1101-2020_06_17_156679	158	11	the	the	DT
10_1101-2020_06_17_156679	158	12	case	case	NN
10_1101-2020_06_17_156679	158	13	of	of	IN
10_1101-2020_06_17_156679	158	14	LON	LON	NNP
10_1101-2020_06_17_156679	158	15	-	-	HYPH
10_1101-2020_06_17_156679	158	16	WEI-297	WEI-297	NNP
10_1101-2020_06_17_156679	158	17	ff7b210a-5	ff7b210a-5	VB
10_1101-2020_06_17_156679	158	18	the	the	DT
10_1101-2020_06_17_156679	158	19	absence	absence	NN
10_1101-2020_06_17_156679	158	20	of	of	IN
10_1101-2020_06_17_156679	158	21	STD	STD	NNP
10_1101-2020_06_17_156679	158	22	signal	signal	NN
10_1101-2020_06_17_156679	158	23	in	in	IN
10_1101-2020_06_17_156679	158	24	the	the	DT
10_1101-2020_06_17_156679	158	25	single	single	JJ
10_1101-2020_06_17_156679	158	26	-	-	HYPH
10_1101-2020_06_17_156679	158	27	concentration	concentration	NN
10_1101-2020_06_17_156679	158	28	NMR	NMR	NNP
10_1101-2020_06_17_156679	158	29	assays	assays	RB
10_1101-2020_06_17_156679	158	30	above	above	RB
10_1101-2020_06_17_156679	158	31	represented	represent	VBD
10_1101-2020_06_17_156679	158	32	a	a	DT
10_1101-2020_06_17_156679	158	33	298	298	CD
10_1101-2020_06_17_156679	158	34	false	false	JJ
10_1101-2020_06_17_156679	158	35	-	-	HYPH
10_1101-2020_06_17_156679	158	36	negative	negative	JJ
10_1101-2020_06_17_156679	158	37	result	result	NN
10_1101-2020_06_17_156679	158	38	.	.	.
10_1101-2020_06_17_156679	159	1	In	in	IN
10_1101-2020_06_17_156679	159	2	contrast	contrast	NN
10_1101-2020_06_17_156679	159	3	,	,	,
10_1101-2020_06_17_156679	159	4	CHO	CHO	NNP
10_1101-2020_06_17_156679	159	5	-	-	HYPH
10_1101-2020_06_17_156679	159	6	MSK-6e55470f-14	MSK-6e55470f-14	NNP
10_1101-2020_06_17_156679	159	7	and	and	CC
10_1101-2020_06_17_156679	159	8	LOR	LOR	NNP
10_1101-2020_06_17_156679	159	9	-	-	HYPH
10_1101-2020_06_17_156679	159	10	NOR-30067bb9	NOR-30067bb9	NNP
10_1101-2020_06_17_156679	159	11	-	-	SYM
10_1101-2020_06_17_156679	159	12	11	11	CD
10_1101-2020_06_17_156679	159	13	were	be	VBD
10_1101-2020_06_17_156679	159	14	unable	unable	JJ
10_1101-2020_06_17_156679	159	15	to	to	IN
10_1101-2020_06_17_156679	159	16	299	299	CD
10_1101-2020_06_17_156679	159	17	compete	compete	VB
10_1101-2020_06_17_156679	159	18	x0434	x0434	NNP
10_1101-2020_06_17_156679	159	19	from	from	IN
10_1101-2020_06_17_156679	159	20	the	the	DT
10_1101-2020_06_17_156679	159	21	protease	protease	NN
10_1101-2020_06_17_156679	159	22	active	active	JJ
10_1101-2020_06_17_156679	159	23	site	site	NN
10_1101-2020_06_17_156679	159	24	(	(	-LRB-
10_1101-2020_06_17_156679	159	25	Fig	fig	NN
10_1101-2020_06_17_156679	159	26	.	.	.
10_1101-2020_06_17_156679	160	1	S5C	s5c	LS
10_1101-2020_06_17_156679	160	2	,	,	,
10_1101-2020_06_17_156679	160	3	D	D	NNP
10_1101-2020_06_17_156679	160	4	)	)	-RRB-
10_1101-2020_06_17_156679	160	5	,	,	,
10_1101-2020_06_17_156679	160	6	suggesting	suggest	VBG
10_1101-2020_06_17_156679	160	7	that	that	IN
10_1101-2020_06_17_156679	160	8	in	in	IN
10_1101-2020_06_17_156679	160	9	these	these	DT
10_1101-2020_06_17_156679	160	10	two	two	CD
10_1101-2020_06_17_156679	160	11	cases	case	NNS
10_1101-2020_06_17_156679	160	12	the	the	DT
10_1101-2020_06_17_156679	160	13	300	300	CD
10_1101-2020_06_17_156679	160	14	reported	report	VBN
10_1101-2020_06_17_156679	160	15	IC50	IC50	NNP
10_1101-2020_06_17_156679	160	16	values	value	NNS
10_1101-2020_06_17_156679	160	17	do	do	VBP
10_1101-2020_06_17_156679	160	18	not	not	RB
10_1101-2020_06_17_156679	160	19	reflect	reflect	VB
10_1101-2020_06_17_156679	160	20	inhibitor	inhibitor	NN
10_1101-2020_06_17_156679	160	21	binding	bind	VBG
10_1101-2020_06_17_156679	160	22	to	to	IN
10_1101-2020_06_17_156679	160	23	the	the	DT
10_1101-2020_06_17_156679	160	24	protease	protease	NN
10_1101-2020_06_17_156679	160	25	,	,	,
10_1101-2020_06_17_156679	160	26	and	and	CC
10_1101-2020_06_17_156679	160	27	that	that	IN
10_1101-2020_06_17_156679	160	28	the	the	DT
10_1101-2020_06_17_156679	160	29	weak	weak	JJ
10_1101-2020_06_17_156679	160	30	STD	STD	NNP
10_1101-2020_06_17_156679	160	31	signal	signal	NN
10_1101-2020_06_17_156679	160	32	of	of	IN
10_1101-2020_06_17_156679	160	33	301	301	CD
10_1101-2020_06_17_156679	160	34	the	the	DT
10_1101-2020_06_17_156679	160	35	initial	initial	NN
10_1101-2020_06_17_156679	160	36	assays	assay	NNS
10_1101-2020_06_17_156679	160	37	was	be	VBD
10_1101-2020_06_17_156679	160	38	a	a	DT
10_1101-2020_06_17_156679	160	39	better	well	JJR
10_1101-2020_06_17_156679	160	40	proxy	proxy	NN
10_1101-2020_06_17_156679	160	41	of	of	IN
10_1101-2020_06_17_156679	160	42	affinity	affinity	NN
10_1101-2020_06_17_156679	160	43	.	.	.
10_1101-2020_06_17_156679	161	1	We	-PRON-	PRP
10_1101-2020_06_17_156679	161	2	surmised	surmise	VBD
10_1101-2020_06_17_156679	161	3	that	that	IN
10_1101-2020_06_17_156679	161	4	although	although	IN
10_1101-2020_06_17_156679	161	5	some	some	DT
10_1101-2020_06_17_156679	161	6	low	low	JJ
10_1101-2020_06_17_156679	161	7	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	161	8	values	value	NNS
10_1101-2020_06_17_156679	161	9	302	302	CD
10_1101-2020_06_17_156679	161	10	of	of	IN
10_1101-2020_06_17_156679	161	11	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	161	12	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	161	13	may	may	MD
10_1101-2020_06_17_156679	161	14	not	not	RB
10_1101-2020_06_17_156679	161	15	accurately	accurately	RB
10_1101-2020_06_17_156679	161	16	reflect	reflect	VB
10_1101-2020_06_17_156679	161	17	compound	compound	NN
10_1101-2020_06_17_156679	161	18	affinity	affinity	NN
10_1101-2020_06_17_156679	161	19	to	to	IN
10_1101-2020_06_17_156679	161	20	the	the	DT
10_1101-2020_06_17_156679	161	21	protease	protease	NN
10_1101-2020_06_17_156679	161	22	,	,	,
10_1101-2020_06_17_156679	161	23	such	such	JJ
10_1101-2020_06_17_156679	161	24	values	value	NNS
10_1101-2020_06_17_156679	161	25	can	can	MD
10_1101-2020_06_17_156679	161	26	not	not	RB
10_1101-2020_06_17_156679	161	27	303	303	CD
10_1101-2020_06_17_156679	161	28	be	be	VB
10_1101-2020_06_17_156679	161	29	discounted	discount	VBN
10_1101-2020_06_17_156679	161	30	as	as	IN
10_1101-2020_06_17_156679	161	31	a	a	DT
10_1101-2020_06_17_156679	161	32	whole	whole	NN
10_1101-2020_06_17_156679	161	33	as	as	IN
10_1101-2020_06_17_156679	161	34	they	-PRON-	PRP
10_1101-2020_06_17_156679	161	35	may	may	MD
10_1101-2020_06_17_156679	161	36	correspond	correspond	VB
10_1101-2020_06_17_156679	161	37	to	to	IN
10_1101-2020_06_17_156679	161	38	non	non	JJ
10_1101-2020_06_17_156679	161	39	-	-	JJ
10_1101-2020_06_17_156679	161	40	binding	binding	JJ
10_1101-2020_06_17_156679	161	41	ligands	ligand	NNS
10_1101-2020_06_17_156679	161	42	.	.	.
10_1101-2020_06_17_156679	162	1	304	304	CD
10_1101-2020_06_17_156679	162	2	305	305	CD
10_1101-2020_06_17_156679	162	3	306	306	CD
10_1101-2020_06_17_156679	162	4	307	307	CD
10_1101-2020_06_17_156679	162	5	308	308	CD
10_1101-2020_06_17_156679	162	6	309	309	CD
10_1101-2020_06_17_156679	162	7	310	310	CD
10_1101-2020_06_17_156679	162	8	311	311	CD
10_1101-2020_06_17_156679	162	9	312	312	CD
10_1101-2020_06_17_156679	162	10	.CC	.CC	:
10_1101-2020_06_17_156679	162	11	-	-	:
10_1101-2020_06_17_156679	162	12	BY	by	IN
10_1101-2020_06_17_156679	162	13	4.0	4.0	CD
10_1101-2020_06_17_156679	162	14	International	International	NNP
10_1101-2020_06_17_156679	162	15	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	162	16	under	under	IN
10_1101-2020_06_17_156679	162	17	a	a	DT
10_1101-2020_06_17_156679	162	18	(	(	-LRB-
10_1101-2020_06_17_156679	162	19	which	which	WDT
10_1101-2020_06_17_156679	162	20	was	be	VBD
10_1101-2020_06_17_156679	162	21	not	not	RB
10_1101-2020_06_17_156679	162	22	certified	certify	VBN
10_1101-2020_06_17_156679	162	23	by	by	IN
10_1101-2020_06_17_156679	162	24	peer	peer	NN
10_1101-2020_06_17_156679	162	25	review	review	NN
10_1101-2020_06_17_156679	162	26	)	)	-RRB-
10_1101-2020_06_17_156679	162	27	is	be	VBZ
10_1101-2020_06_17_156679	162	28	the	the	DT
10_1101-2020_06_17_156679	162	29	author	author	NN
10_1101-2020_06_17_156679	162	30	/	/	SYM
10_1101-2020_06_17_156679	162	31	funder	funder	NN
10_1101-2020_06_17_156679	162	32	,	,	,
10_1101-2020_06_17_156679	162	33	who	who	WP
10_1101-2020_06_17_156679	162	34	has	have	VBZ
10_1101-2020_06_17_156679	162	35	granted	grant	VBN
10_1101-2020_06_17_156679	162	36	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	162	37	a	a	DT
10_1101-2020_06_17_156679	162	38	license	license	NN
10_1101-2020_06_17_156679	162	39	to	to	TO
10_1101-2020_06_17_156679	162	40	display	display	VB
10_1101-2020_06_17_156679	162	41	the	the	DT
10_1101-2020_06_17_156679	162	42	preprint	preprint	NN
10_1101-2020_06_17_156679	162	43	in	in	IN
10_1101-2020_06_17_156679	162	44	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	162	45	.	.	.
10_1101-2020_06_17_156679	163	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	163	2	is	be	VBZ
10_1101-2020_06_17_156679	163	3	made	make	VBN
10_1101-2020_06_17_156679	163	4	The	the	DT
10_1101-2020_06_17_156679	163	5	copyright	copyright	NN
10_1101-2020_06_17_156679	163	6	holder	holder	NN
10_1101-2020_06_17_156679	163	7	for	for	IN
10_1101-2020_06_17_156679	163	8	this	this	DT
10_1101-2020_06_17_156679	163	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	163	10	version	version	NN
10_1101-2020_06_17_156679	163	11	posted	post	VBD
10_1101-2020_06_17_156679	163	12	January	January	NNP
10_1101-2020_06_17_156679	163	13	6	6	CD
10_1101-2020_06_17_156679	163	14	,	,	,
10_1101-2020_06_17_156679	163	15	2021	2021	CD
10_1101-2020_06_17_156679	163	16	.	.	.
10_1101-2020_06_17_156679	163	17	;	;	:
10_1101-2020_06_17_156679	163	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	163	19	:	:	:
10_1101-2020_06_17_156679	163	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	163	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	163	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	163	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	163	24	12	12	CD
10_1101-2020_06_17_156679	163	25	Discussion	Discussion	NNP
10_1101-2020_06_17_156679	163	26	313	313	NNP
10_1101-2020_06_17_156679	163	27	Fragment	Fragment	NNP
10_1101-2020_06_17_156679	163	28	-	-	HYPH
10_1101-2020_06_17_156679	163	29	based	base	VBN
10_1101-2020_06_17_156679	163	30	screening	screening	NN
10_1101-2020_06_17_156679	163	31	is	be	VBZ
10_1101-2020_06_17_156679	163	32	a	a	DT
10_1101-2020_06_17_156679	163	33	tried	try	VBN
10_1101-2020_06_17_156679	163	34	and	and	CC
10_1101-2020_06_17_156679	163	35	tested	test	VBN
10_1101-2020_06_17_156679	163	36	method	method	NN
10_1101-2020_06_17_156679	163	37	for	for	IN
10_1101-2020_06_17_156679	163	38	reducing	reduce	VBG
10_1101-2020_06_17_156679	163	39	the	the	DT
10_1101-2020_06_17_156679	163	40	number	number	NN
10_1101-2020_06_17_156679	163	41	of	of	IN
10_1101-2020_06_17_156679	163	42	compounds	compound	NNS
10_1101-2020_06_17_156679	163	43	314	314	CD
10_1101-2020_06_17_156679	163	44	that	that	WDT
10_1101-2020_06_17_156679	163	45	need	need	VBP
10_1101-2020_06_17_156679	163	46	to	to	TO
10_1101-2020_06_17_156679	163	47	be	be	VB
10_1101-2020_06_17_156679	163	48	assessed	assess	VBN
10_1101-2020_06_17_156679	163	49	for	for	IN
10_1101-2020_06_17_156679	163	50	binding	bind	VBG
10_1101-2020_06_17_156679	163	51	against	against	IN
10_1101-2020_06_17_156679	163	52	a	a	DT
10_1101-2020_06_17_156679	163	53	specific	specific	JJ
10_1101-2020_06_17_156679	163	54	target	target	NN
10_1101-2020_06_17_156679	163	55	in	in	IN
10_1101-2020_06_17_156679	163	56	order	order	NN
10_1101-2020_06_17_156679	163	57	to	to	TO
10_1101-2020_06_17_156679	163	58	sample	sample	VB
10_1101-2020_06_17_156679	163	59	chemical	chemical	NN
10_1101-2020_06_17_156679	163	60	space	space	NN
10_1101-2020_06_17_156679	163	61	(	(	-LRB-
10_1101-2020_06_17_156679	163	62	36	36	CD
10_1101-2020_06_17_156679	163	63	)	)	-RRB-
10_1101-2020_06_17_156679	163	64	.	.	.
10_1101-2020_06_17_156679	164	1	315	315	CD
10_1101-2020_06_17_156679	164	2	Combined	combine	VBN
10_1101-2020_06_17_156679	164	3	with	with	IN
10_1101-2020_06_17_156679	164	4	X	x	NN
10_1101-2020_06_17_156679	164	5	-	-	NN
10_1101-2020_06_17_156679	164	6	ray	ray	NN
10_1101-2020_06_17_156679	164	7	crystallography	crystallography	NN
10_1101-2020_06_17_156679	164	8	,	,	,
10_1101-2020_06_17_156679	164	9	which	which	WDT
10_1101-2020_06_17_156679	164	10	provides	provide	VBZ
10_1101-2020_06_17_156679	164	11	information	information	NN
10_1101-2020_06_17_156679	164	12	on	on	IN
10_1101-2020_06_17_156679	164	13	the	the	DT
10_1101-2020_06_17_156679	164	14	target	target	NN
10_1101-2020_06_17_156679	164	15	site	site	NN
10_1101-2020_06_17_156679	164	16	and	and	CC
10_1101-2020_06_17_156679	164	17	binding	bind	VBG
10_1101-2020_06_17_156679	164	18	316	316	CD
10_1101-2020_06_17_156679	164	19	pose	pose	NN
10_1101-2020_06_17_156679	164	20	of	of	IN
10_1101-2020_06_17_156679	164	21	ligands	ligand	NNS
10_1101-2020_06_17_156679	164	22	,	,	,
10_1101-2020_06_17_156679	164	23	initial	initial	JJ
10_1101-2020_06_17_156679	164	24	fragments	fragment	NNS
10_1101-2020_06_17_156679	164	25	can	can	MD
10_1101-2020_06_17_156679	164	26	quickly	quickly	RB
10_1101-2020_06_17_156679	164	27	be	be	VB
10_1101-2020_06_17_156679	164	28	iterated	iterate	VBN
10_1101-2020_06_17_156679	164	29	into	into	IN
10_1101-2020_06_17_156679	164	30	potent	potent	JJ
10_1101-2020_06_17_156679	164	31	and	and	CC
10_1101-2020_06_17_156679	164	32	specifically	specifically	RB
10_1101-2020_06_17_156679	164	33	-	-	HYPH
10_1101-2020_06_17_156679	164	34	interacting	interact	VBG
10_1101-2020_06_17_156679	164	35	317	317	CD
10_1101-2020_06_17_156679	164	36	compounds	compound	NNS
10_1101-2020_06_17_156679	164	37	.	.	.
10_1101-2020_06_17_156679	165	1	The	the	DT
10_1101-2020_06_17_156679	165	2	COVID	COVID	NNP
10_1101-2020_06_17_156679	165	3	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	165	4	collaboration	collaboration	NN
10_1101-2020_06_17_156679	165	5	(	(	-LRB-
10_1101-2020_06_17_156679	165	6	17	17	CD
10_1101-2020_06_17_156679	165	7	)	)	-RRB-
10_1101-2020_06_17_156679	165	8	took	take	VBD
10_1101-2020_06_17_156679	165	9	advantage	advantage	NN
10_1101-2020_06_17_156679	165	10	of	of	IN
10_1101-2020_06_17_156679	165	11	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	165	12	fragment-318	fragment-318	.
10_1101-2020_06_17_156679	165	13	based	base	VBN
10_1101-2020_06_17_156679	165	14	screening	screening	NN
10_1101-2020_06_17_156679	165	15	(	(	-LRB-
10_1101-2020_06_17_156679	165	16	18	18	CD
10_1101-2020_06_17_156679	165	17	)	)	-RRB-
10_1101-2020_06_17_156679	165	18	to	to	TO
10_1101-2020_06_17_156679	165	19	initiate	initiate	VB
10_1101-2020_06_17_156679	165	20	the	the	DT
10_1101-2020_06_17_156679	165	21	design	design	NN
10_1101-2020_06_17_156679	165	22	of	of	IN
10_1101-2020_06_17_156679	165	23	novel	novel	JJ
10_1101-2020_06_17_156679	165	24	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	165	25	targeting	target	VBG
10_1101-2020_06_17_156679	165	26	the	the	DT
10_1101-2020_06_17_156679	165	27	essential	essential	JJ
10_1101-2020_06_17_156679	165	28	main	main	JJ
10_1101-2020_06_17_156679	165	29	protease	protease	NN
10_1101-2020_06_17_156679	165	30	319	319	CD
10_1101-2020_06_17_156679	165	31	of	of	IN
10_1101-2020_06_17_156679	165	32	the	the	DT
10_1101-2020_06_17_156679	165	33	SARS	SARS	NNP
10_1101-2020_06_17_156679	165	34	-	-	HYPH
10_1101-2020_06_17_156679	165	35	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	165	36	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	165	37	;	;	:
10_1101-2020_06_17_156679	165	38	however	however	RB
10_1101-2020_06_17_156679	165	39	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	165	40	structures	structure	NNS
10_1101-2020_06_17_156679	165	41	do	do	VBP
10_1101-2020_06_17_156679	165	42	not	not	RB
10_1101-2020_06_17_156679	165	43	report	report	VB
10_1101-2020_06_17_156679	165	44	on	on	IN
10_1101-2020_06_17_156679	165	45	ligand	ligand	NNP
10_1101-2020_06_17_156679	165	46	affinity	affinity	NN
10_1101-2020_06_17_156679	165	47	320	320	CD
10_1101-2020_06_17_156679	165	48	and	and	CC
10_1101-2020_06_17_156679	165	49	inhibitory	inhibitory	NN
10_1101-2020_06_17_156679	165	50	potency	potency	NN
10_1101-2020_06_17_156679	165	51	in	in	IN
10_1101-2020_06_17_156679	165	52	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	165	53	assays	assay	NNS
10_1101-2020_06_17_156679	165	54	does	do	VBZ
10_1101-2020_06_17_156679	165	55	not	not	RB
10_1101-2020_06_17_156679	165	56	always	always	RB
10_1101-2020_06_17_156679	165	57	correlate	correlate	VB
10_1101-2020_06_17_156679	165	58	with	with	IN
10_1101-2020_06_17_156679	165	59	ligand	ligand	NN
10_1101-2020_06_17_156679	165	60	binding	binding	NN
10_1101-2020_06_17_156679	165	61	.	.	.
10_1101-2020_06_17_156679	166	1	Thus	thus	RB
10_1101-2020_06_17_156679	166	2	,	,	,
10_1101-2020_06_17_156679	166	3	321	321	CD
10_1101-2020_06_17_156679	166	4	supplementing	supplement	VBG
10_1101-2020_06_17_156679	166	5	these	these	DT
10_1101-2020_06_17_156679	166	6	methods	method	NNS
10_1101-2020_06_17_156679	166	7	with	with	IN
10_1101-2020_06_17_156679	166	8	solution	solution	NN
10_1101-2020_06_17_156679	166	9	NMR	NMR	NNP
10_1101-2020_06_17_156679	166	10	tools	tool	NNS
10_1101-2020_06_17_156679	166	11	highly	highly	RB
10_1101-2020_06_17_156679	166	12	sensitive	sensitive	JJ
10_1101-2020_06_17_156679	166	13	to	to	IN
10_1101-2020_06_17_156679	166	14	ligand	ligand	NN
10_1101-2020_06_17_156679	166	15	binding	binding	NN
10_1101-2020_06_17_156679	166	16	can	can	MD
10_1101-2020_06_17_156679	166	17	provide	provide	VB
10_1101-2020_06_17_156679	166	18	322	322	CD
10_1101-2020_06_17_156679	166	19	a	a	DT
10_1101-2020_06_17_156679	166	20	powerful	powerful	JJ
10_1101-2020_06_17_156679	166	21	combination	combination	NN
10_1101-2020_06_17_156679	166	22	of	of	IN
10_1101-2020_06_17_156679	166	23	orthogonal	orthogonal	JJ
10_1101-2020_06_17_156679	166	24	information	information	NN
10_1101-2020_06_17_156679	166	25	and	and	CC
10_1101-2020_06_17_156679	166	26	assurance	assurance	NN
10_1101-2020_06_17_156679	166	27	against	against	IN
10_1101-2020_06_17_156679	166	28	false	false	JJ
10_1101-2020_06_17_156679	166	29	starts	start	NNS
10_1101-2020_06_17_156679	166	30	.	.	.
10_1101-2020_06_17_156679	167	1	323	323	LS
10_1101-2020_06_17_156679	167	2	We	-PRON-	PRP
10_1101-2020_06_17_156679	167	3	showed	show	VBD
10_1101-2020_06_17_156679	167	4	that	that	IN
10_1101-2020_06_17_156679	167	5	STD	STD	NNP
10_1101-2020_06_17_156679	167	6	-	-	HYPH
10_1101-2020_06_17_156679	167	7	NMR	NMR	NNP
10_1101-2020_06_17_156679	167	8	is	be	VBZ
10_1101-2020_06_17_156679	167	9	a	a	DT
10_1101-2020_06_17_156679	167	10	suitable	suitable	JJ
10_1101-2020_06_17_156679	167	11	method	method	NN
10_1101-2020_06_17_156679	167	12	for	for	IN
10_1101-2020_06_17_156679	167	13	characterising	characterise	VBG
10_1101-2020_06_17_156679	167	14	ligand	ligand	NN
10_1101-2020_06_17_156679	167	15	binding	bind	VBG
10_1101-2020_06_17_156679	167	16	to	to	IN
10_1101-2020_06_17_156679	167	17	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	167	18	,	,	,
10_1101-2020_06_17_156679	167	19	allowing	allow	VBG
10_1101-2020_06_17_156679	167	20	324	324	CD
10_1101-2020_06_17_156679	167	21	us	-PRON-	PRP
10_1101-2020_06_17_156679	167	22	to	to	TO
10_1101-2020_06_17_156679	167	23	assess	assess	VB
10_1101-2020_06_17_156679	167	24	ligand	ligand	NN
10_1101-2020_06_17_156679	167	25	interactions	interaction	NNS
10_1101-2020_06_17_156679	167	26	using	use	VBG
10_1101-2020_06_17_156679	167	27	relatively	relatively	RB
10_1101-2020_06_17_156679	167	28	small	small	JJ
10_1101-2020_06_17_156679	167	29	amounts	amount	NNS
10_1101-2020_06_17_156679	167	30	of	of	IN
10_1101-2020_06_17_156679	167	31	protein	protein	NN
10_1101-2020_06_17_156679	167	32	and	and	CC
10_1101-2020_06_17_156679	167	33	in	in	RB
10_1101-2020_06_17_156679	167	34	under	under	IN
10_1101-2020_06_17_156679	167	35	one	one	CD
10_1101-2020_06_17_156679	167	36	hour	hour	NN
10_1101-2020_06_17_156679	167	37	of	of	IN
10_1101-2020_06_17_156679	167	38	325	325	CD
10_1101-2020_06_17_156679	167	39	experiment	experiment	NN
10_1101-2020_06_17_156679	167	40	time	time	NN
10_1101-2020_06_17_156679	167	41	per	per	IN
10_1101-2020_06_17_156679	167	42	ligand	ligand	NN
10_1101-2020_06_17_156679	167	43	(	(	-LRB-
10_1101-2020_06_17_156679	167	44	Fig	fig	NN
10_1101-2020_06_17_156679	167	45	.	.	.
10_1101-2020_06_17_156679	168	1	1B	1B	NNP
10_1101-2020_06_17_156679	168	2	)	)	-RRB-
10_1101-2020_06_17_156679	168	3	.	.	.
10_1101-2020_06_17_156679	169	1	However	however	RB
10_1101-2020_06_17_156679	169	2	,	,	,
10_1101-2020_06_17_156679	169	3	screening	screen	VBG
10_1101-2020_06_17_156679	169	4	compounds	compound	NNS
10_1101-2020_06_17_156679	169	5	in	in	IN
10_1101-2020_06_17_156679	169	6	a	a	DT
10_1101-2020_06_17_156679	169	7	high	high	JJ
10_1101-2020_06_17_156679	169	8	-	-	HYPH
10_1101-2020_06_17_156679	169	9	throughput	throughput	NN
10_1101-2020_06_17_156679	169	10	manner	manner	NN
10_1101-2020_06_17_156679	169	11	is	be	VBZ
10_1101-2020_06_17_156679	169	12	326	326	CD
10_1101-2020_06_17_156679	169	13	not	not	RB
10_1101-2020_06_17_156679	169	14	compatible	compatible	JJ
10_1101-2020_06_17_156679	169	15	with	with	IN
10_1101-2020_06_17_156679	169	16	the	the	DT
10_1101-2020_06_17_156679	169	17	time-	time-	NNP
10_1101-2020_06_17_156679	169	18	and	and	CC
10_1101-2020_06_17_156679	169	19	ligand	ligand	NNP
10_1101-2020_06_17_156679	169	20	-	-	HYPH
10_1101-2020_06_17_156679	169	21	amount	amount	NN
10_1101-2020_06_17_156679	169	22	requirements	requirement	NNS
10_1101-2020_06_17_156679	169	23	of	of	IN
10_1101-2020_06_17_156679	169	24	full	full	JJ
10_1101-2020_06_17_156679	169	25	STD	STD	NNP
10_1101-2020_06_17_156679	169	26	-	-	HYPH
10_1101-2020_06_17_156679	169	27	NMR	NMR	NNP
10_1101-2020_06_17_156679	169	28	titrations	titration	NNS
10_1101-2020_06_17_156679	169	29	.	.	.
10_1101-2020_06_17_156679	170	1	Thus	thus	RB
10_1101-2020_06_17_156679	170	2	,	,	,
10_1101-2020_06_17_156679	170	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	170	4	327	327	CD
10_1101-2020_06_17_156679	170	5	resorted	resort	VBD
10_1101-2020_06_17_156679	170	6	to	to	IN
10_1101-2020_06_17_156679	170	7	using	use	VBG
10_1101-2020_06_17_156679	170	8	an	an	DT
10_1101-2020_06_17_156679	170	9	unconventional	unconventional	JJ
10_1101-2020_06_17_156679	170	10	metric	metric	NN
10_1101-2020_06_17_156679	170	11	,	,	,
10_1101-2020_06_17_156679	170	12	the	the	DT
10_1101-2020_06_17_156679	170	13	single	single	JJ
10_1101-2020_06_17_156679	170	14	-	-	HYPH
10_1101-2020_06_17_156679	170	15	concentration	concentration	NN
10_1101-2020_06_17_156679	170	16	STDratio	stdratio	NN
10_1101-2020_06_17_156679	170	17	value	value	NN
10_1101-2020_06_17_156679	170	18	,	,	,
10_1101-2020_06_17_156679	170	19	as	as	IN
10_1101-2020_06_17_156679	170	20	proxy	proxy	NN
10_1101-2020_06_17_156679	170	21	for	for	IN
10_1101-2020_06_17_156679	170	22	328	328	CD
10_1101-2020_06_17_156679	170	23	ligand	ligand	NN
10_1101-2020_06_17_156679	170	24	affinity	affinity	NN
10_1101-2020_06_17_156679	170	25	.	.	.
10_1101-2020_06_17_156679	171	1	Although	although	IN
10_1101-2020_06_17_156679	171	2	this	this	DT
10_1101-2020_06_17_156679	171	3	metric	metric	NN
10_1101-2020_06_17_156679	171	4	has	have	VBZ
10_1101-2020_06_17_156679	171	5	limitations	limitation	NNS
10_1101-2020_06_17_156679	171	6	due	due	JJ
10_1101-2020_06_17_156679	171	7	to	to	IN
10_1101-2020_06_17_156679	171	8	its	-PRON-	PRP$
10_1101-2020_06_17_156679	171	9	dependency	dependency	NN
10_1101-2020_06_17_156679	171	10	on	on	IN
10_1101-2020_06_17_156679	171	11	magnetisation	magnetisation	NN
10_1101-2020_06_17_156679	171	12	transfer	transfer	NN
10_1101-2020_06_17_156679	171	13	329	329	CD
10_1101-2020_06_17_156679	171	14	between	between	IN
10_1101-2020_06_17_156679	171	15	protein	protein	NN
10_1101-2020_06_17_156679	171	16	and	and	CC
10_1101-2020_06_17_156679	171	17	ligand	ligand	NNP
10_1101-2020_06_17_156679	171	18	,	,	,
10_1101-2020_06_17_156679	171	19	and	and	CC
10_1101-2020_06_17_156679	171	20	on	on	IN
10_1101-2020_06_17_156679	171	21	relatively	relatively	RB
10_1101-2020_06_17_156679	171	22	rapid	rapid	JJ
10_1101-2020_06_17_156679	171	23	exchange	exchange	NN
10_1101-2020_06_17_156679	171	24	between	between	IN
10_1101-2020_06_17_156679	171	25	the	the	DT
10_1101-2020_06_17_156679	171	26	ligand	ligand	NN
10_1101-2020_06_17_156679	171	27	-	-	HYPH
10_1101-2020_06_17_156679	171	28	free	free	JJ
10_1101-2020_06_17_156679	171	29	and	and	CC
10_1101-2020_06_17_156679	171	30	-bound	-bound	JJ
10_1101-2020_06_17_156679	171	31	330	330	CD
10_1101-2020_06_17_156679	171	32	states	state	NNS
10_1101-2020_06_17_156679	171	33	,	,	,
10_1101-2020_06_17_156679	171	34	we	-PRON-	PRP
10_1101-2020_06_17_156679	171	35	demonstrated	demonstrate	VBD
10_1101-2020_06_17_156679	171	36	that	that	IN
10_1101-2020_06_17_156679	171	37	it	-PRON-	PRP
10_1101-2020_06_17_156679	171	38	can	can	MD
10_1101-2020_06_17_156679	171	39	nevertheless	nevertheless	RB
10_1101-2020_06_17_156679	171	40	be	be	VB
10_1101-2020_06_17_156679	171	41	informative	informative	JJ
10_1101-2020_06_17_156679	171	42	.	.	.
10_1101-2020_06_17_156679	172	1	Specifically	specifically	RB
10_1101-2020_06_17_156679	172	2	,	,	,
10_1101-2020_06_17_156679	172	3	the	the	DT
10_1101-2020_06_17_156679	172	4	relative	relative	JJ
10_1101-2020_06_17_156679	172	5	STDratio	stdratio	NN
10_1101-2020_06_17_156679	172	6	331	331	CD
10_1101-2020_06_17_156679	172	7	values	value	NNS
10_1101-2020_06_17_156679	172	8	of	of	IN
10_1101-2020_06_17_156679	172	9	chemical	chemical	NN
10_1101-2020_06_17_156679	172	10	fragments	fragment	NNS
10_1101-2020_06_17_156679	172	11	bound	bind	VBN
10_1101-2020_06_17_156679	172	12	to	to	IN
10_1101-2020_06_17_156679	172	13	the	the	DT
10_1101-2020_06_17_156679	172	14	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	172	15	active	active	JJ
10_1101-2020_06_17_156679	172	16	site	site	NN
10_1101-2020_06_17_156679	172	17	provided	provide	VBN
10_1101-2020_06_17_156679	172	18	insight	insight	NN
10_1101-2020_06_17_156679	172	19	on	on	IN
10_1101-2020_06_17_156679	172	20	fragment	fragment	NN
10_1101-2020_06_17_156679	172	21	affinity	affinity	NN
10_1101-2020_06_17_156679	172	22	(	(	-LRB-
10_1101-2020_06_17_156679	172	23	Fig	fig	NN
10_1101-2020_06_17_156679	172	24	.	.	.
10_1101-2020_06_17_156679	173	1	332	332	CD
10_1101-2020_06_17_156679	173	2	2A	2a	NN
10_1101-2020_06_17_156679	173	3	)	)	-RRB-
10_1101-2020_06_17_156679	173	4	,	,	,
10_1101-2020_06_17_156679	173	5	as	as	IN
10_1101-2020_06_17_156679	173	6	crosschecked	crosschecke	VBN
10_1101-2020_06_17_156679	173	7	by	by	IN
10_1101-2020_06_17_156679	173	8	quantitative	quantitative	JJ
10_1101-2020_06_17_156679	173	9	titrations	titration	NNS
10_1101-2020_06_17_156679	173	10	(	(	-LRB-
10_1101-2020_06_17_156679	173	11	Fig	fig	NN
10_1101-2020_06_17_156679	173	12	.	.	.
10_1101-2020_06_17_156679	174	1	S2	s2	NN
10_1101-2020_06_17_156679	174	2	)	)	-RRB-
10_1101-2020_06_17_156679	174	3	and	and	CC
10_1101-2020_06_17_156679	174	4	MD	MD	NNP
10_1101-2020_06_17_156679	174	5	simulations	simulation	NNS
10_1101-2020_06_17_156679	174	6	(	(	-LRB-
10_1101-2020_06_17_156679	174	7	Fig	fig	NN
10_1101-2020_06_17_156679	174	8	.	.	.
10_1101-2020_06_17_156679	175	1	S3	S3	NNP
10_1101-2020_06_17_156679	175	2	)	)	-RRB-
10_1101-2020_06_17_156679	175	3	.	.	.
10_1101-2020_06_17_156679	176	1	Furthermore	furthermore	RB
10_1101-2020_06_17_156679	176	2	,	,	,
10_1101-2020_06_17_156679	176	3	333	333	CD
10_1101-2020_06_17_156679	176	4	STDratio	stdratio	NN
10_1101-2020_06_17_156679	176	5	values	value	NNS
10_1101-2020_06_17_156679	176	6	of	of	IN
10_1101-2020_06_17_156679	176	7	COVID	COVID	NNP
10_1101-2020_06_17_156679	176	8	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	176	9	compounds	compound	NNS
10_1101-2020_06_17_156679	176	10	held	hold	VBD
10_1101-2020_06_17_156679	176	11	a	a	DT
10_1101-2020_06_17_156679	176	12	weak	weak	JJ
10_1101-2020_06_17_156679	176	13	correlation	correlation	NN
10_1101-2020_06_17_156679	176	14	to	to	IN
10_1101-2020_06_17_156679	176	15	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	176	16	IC50	IC50	NNP
10_1101-2020_06_17_156679	176	17	parameters	parameter	NNS
10_1101-2020_06_17_156679	176	18	334	334	CD
10_1101-2020_06_17_156679	176	19	(	(	-LRB-
10_1101-2020_06_17_156679	176	20	Fig	fig	NN
10_1101-2020_06_17_156679	176	21	.	.	.
10_1101-2020_06_17_156679	177	1	3B	3B	NNP
10_1101-2020_06_17_156679	177	2	)	)	-RRB-
10_1101-2020_06_17_156679	177	3	,	,	,
10_1101-2020_06_17_156679	177	4	although	although	IN
10_1101-2020_06_17_156679	177	5	false	false	JJ
10_1101-2020_06_17_156679	177	6	-	-	HYPH
10_1101-2020_06_17_156679	177	7	negative	negative	JJ
10_1101-2020_06_17_156679	177	8	and	and	CC
10_1101-2020_06_17_156679	177	9	-positive	-positive	JJ
10_1101-2020_06_17_156679	177	10	results	result	NNS
10_1101-2020_06_17_156679	177	11	from	from	IN
10_1101-2020_06_17_156679	177	12	both	both	DT
10_1101-2020_06_17_156679	177	13	methods	method	NNS
10_1101-2020_06_17_156679	177	14	contribute	contribute	VBP
10_1101-2020_06_17_156679	177	15	to	to	IN
10_1101-2020_06_17_156679	177	16	multiple	multiple	JJ
10_1101-2020_06_17_156679	177	17	335	335	CD
10_1101-2020_06_17_156679	177	18	outliers	outlier	NNS
10_1101-2020_06_17_156679	177	19	.	.	.
10_1101-2020_06_17_156679	178	1	Thus	thus	RB
10_1101-2020_06_17_156679	178	2	,	,	,
10_1101-2020_06_17_156679	178	3	in	in	IN
10_1101-2020_06_17_156679	178	4	our	-PRON-	PRP$
10_1101-2020_06_17_156679	178	5	view	view	NN
10_1101-2020_06_17_156679	178	6	the	the	DT
10_1101-2020_06_17_156679	178	7	biggest	big	JJS
10_1101-2020_06_17_156679	178	8	limitation	limitation	NN
10_1101-2020_06_17_156679	178	9	of	of	IN
10_1101-2020_06_17_156679	178	10	using	use	VBG
10_1101-2020_06_17_156679	178	11	the	the	DT
10_1101-2020_06_17_156679	178	12	single	single	JJ
10_1101-2020_06_17_156679	178	13	-	-	HYPH
10_1101-2020_06_17_156679	178	14	concentration	concentration	NN
10_1101-2020_06_17_156679	178	15	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	178	16	value	value	NN
10_1101-2020_06_17_156679	178	17	as	as	IN
10_1101-2020_06_17_156679	178	18	336	336	CD
10_1101-2020_06_17_156679	178	19	metric	metric	JJ
10_1101-2020_06_17_156679	178	20	relates	relate	VBZ
10_1101-2020_06_17_156679	178	21	to	to	IN
10_1101-2020_06_17_156679	178	22	its	-PRON-	PRP$
10_1101-2020_06_17_156679	178	23	supra	supra	JJ
10_1101-2020_06_17_156679	178	24	-	-	HYPH
10_1101-2020_06_17_156679	178	25	linear	linear	JJ
10_1101-2020_06_17_156679	178	26	sensitivity	sensitivity	NN
10_1101-2020_06_17_156679	178	27	to	to	IN
10_1101-2020_06_17_156679	178	28	ligand	ligand	VB
10_1101-2020_06_17_156679	178	29	concentration	concentration	NN
10_1101-2020_06_17_156679	178	30	(	(	-LRB-
10_1101-2020_06_17_156679	178	31	Fig	fig	NN
10_1101-2020_06_17_156679	178	32	.	.	.
10_1101-2020_06_17_156679	179	1	S1	S1	NNP
10_1101-2020_06_17_156679	179	2	)	)	-RRB-
10_1101-2020_06_17_156679	179	3	,	,	,
10_1101-2020_06_17_156679	179	4	which	which	WDT
10_1101-2020_06_17_156679	179	5	as	as	IN
10_1101-2020_06_17_156679	179	6	demonstrated	demonstrate	VBD
10_1101-2020_06_17_156679	179	7	337	337	CD
10_1101-2020_06_17_156679	179	8	here	here	RB
10_1101-2020_06_17_156679	179	9	can	can	MD
10_1101-2020_06_17_156679	179	10	vary	vary	VB
10_1101-2020_06_17_156679	179	11	substantially	substantially	RB
10_1101-2020_06_17_156679	179	12	across	across	IN
10_1101-2020_06_17_156679	179	13	ligands	ligand	NNS
10_1101-2020_06_17_156679	179	14	in	in	IN
10_1101-2020_06_17_156679	179	15	a	a	DT
10_1101-2020_06_17_156679	179	16	large	large	JJ
10_1101-2020_06_17_156679	179	17	project	project	NN
10_1101-2020_06_17_156679	179	18	(	(	-LRB-
10_1101-2020_06_17_156679	179	19	Fig	fig	NN
10_1101-2020_06_17_156679	179	20	.	.	.
10_1101-2020_06_17_156679	180	1	3A	3A	NNP
10_1101-2020_06_17_156679	180	2	)	)	-RRB-
10_1101-2020_06_17_156679	180	3	.	.	.
10_1101-2020_06_17_156679	181	1	338	338	CD
10_1101-2020_06_17_156679	181	2	How	how	WRB
10_1101-2020_06_17_156679	181	3	then	then	RB
10_1101-2020_06_17_156679	181	4	should	should	MD
10_1101-2020_06_17_156679	181	5	the	the	DT
10_1101-2020_06_17_156679	181	6	STD	STD	NNP
10_1101-2020_06_17_156679	181	7	data	datum	NNS
10_1101-2020_06_17_156679	181	8	recorded	record	VBN
10_1101-2020_06_17_156679	181	9	as	as	IN
10_1101-2020_06_17_156679	181	10	part	part	NN
10_1101-2020_06_17_156679	181	11	of	of	IN
10_1101-2020_06_17_156679	181	12	COVID	COVID	NNP
10_1101-2020_06_17_156679	181	13	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	181	14	be	be	VB
10_1101-2020_06_17_156679	181	15	used	use	VBN
10_1101-2020_06_17_156679	181	16	?	?	.
10_1101-2020_06_17_156679	182	1	Firstly	firstly	RB
10_1101-2020_06_17_156679	182	2	,	,	,
10_1101-2020_06_17_156679	182	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	182	4	showed	show	VBD
10_1101-2020_06_17_156679	182	5	339	339	CD
10_1101-2020_06_17_156679	182	6	that	that	IN
10_1101-2020_06_17_156679	182	7	at	at	IN
10_1101-2020_06_17_156679	182	8	least	least	JJS
10_1101-2020_06_17_156679	182	9	for	for	IN
10_1101-2020_06_17_156679	182	10	some	some	DT
10_1101-2020_06_17_156679	182	11	bespoke	bespoke	NN
10_1101-2020_06_17_156679	182	12	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	182	13	ligands	ligand	VBZ
10_1101-2020_06_17_156679	182	14	the	the	DT
10_1101-2020_06_17_156679	182	15	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	182	16	value	value	NN
10_1101-2020_06_17_156679	182	17	obtained	obtain	VBN
10_1101-2020_06_17_156679	182	18	is	be	VBZ
10_1101-2020_06_17_156679	182	19	a	a	DT
10_1101-2020_06_17_156679	182	20	better	well	JJR
10_1101-2020_06_17_156679	182	21	proxy	proxy	NN
10_1101-2020_06_17_156679	182	22	for	for	IN
10_1101-2020_06_17_156679	182	23	340	340	CD
10_1101-2020_06_17_156679	182	24	compound	compound	NN
10_1101-2020_06_17_156679	182	25	affinity	affinity	NN
10_1101-2020_06_17_156679	182	26	compared	compare	VBN
10_1101-2020_06_17_156679	182	27	to	to	IN
10_1101-2020_06_17_156679	182	28	IC50	IC50	NNP
10_1101-2020_06_17_156679	182	29	parameters	parameter	NNS
10_1101-2020_06_17_156679	182	30	from	from	IN
10_1101-2020_06_17_156679	182	31	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	182	32	assays	assays	RB
10_1101-2020_06_17_156679	182	33	(	(	-LRB-
10_1101-2020_06_17_156679	182	34	Fig	fig	NN
10_1101-2020_06_17_156679	182	35	.	.	.
10_1101-2020_06_17_156679	183	1	S5	S5	NNP
10_1101-2020_06_17_156679	183	2	)	)	-RRB-
10_1101-2020_06_17_156679	183	3	.	.	.
10_1101-2020_06_17_156679	184	1	This	this	DT
10_1101-2020_06_17_156679	184	2	,	,	,
10_1101-2020_06_17_156679	184	3	inherently	inherently	RB
10_1101-2020_06_17_156679	184	4	,	,	,
10_1101-2020_06_17_156679	184	5	is	be	VBZ
10_1101-2020_06_17_156679	184	6	341	341	CD
10_1101-2020_06_17_156679	184	7	the	the	DT
10_1101-2020_06_17_156679	184	8	value	value	NN
10_1101-2020_06_17_156679	184	9	of	of	IN
10_1101-2020_06_17_156679	184	10	employing	employ	VBG
10_1101-2020_06_17_156679	184	11	orthogonal	orthogonal	JJ
10_1101-2020_06_17_156679	184	12	methods	method	NNS
10_1101-2020_06_17_156679	184	13	thereby	thereby	RB
10_1101-2020_06_17_156679	184	14	minimizing	minimize	VBG
10_1101-2020_06_17_156679	184	15	the	the	DT
10_1101-2020_06_17_156679	184	16	number	number	NN
10_1101-2020_06_17_156679	184	17	of	of	IN
10_1101-2020_06_17_156679	184	18	potential	potential	JJ
10_1101-2020_06_17_156679	184	19	false	false	JJ
10_1101-2020_06_17_156679	184	20	342	342	CD
10_1101-2020_06_17_156679	184	21	results	result	NNS
10_1101-2020_06_17_156679	184	22	.	.	.
10_1101-2020_06_17_156679	185	1	Thus	thus	RB
10_1101-2020_06_17_156679	185	2	,	,	,
10_1101-2020_06_17_156679	185	3	when	when	WRB
10_1101-2020_06_17_156679	185	4	one	one	NN
10_1101-2020_06_17_156679	185	5	is	be	VBZ
10_1101-2020_06_17_156679	185	6	considering	consider	VBG
10_1101-2020_06_17_156679	185	7	existing	exist	VBG
10_1101-2020_06_17_156679	185	8	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	185	9	ligands	ligand	NNS
10_1101-2020_06_17_156679	185	10	to	to	TO
10_1101-2020_06_17_156679	185	11	base	base	VB
10_1101-2020_06_17_156679	185	12	the	the	DT
10_1101-2020_06_17_156679	185	13	design	design	NN
10_1101-2020_06_17_156679	185	14	of	of	IN
10_1101-2020_06_17_156679	185	15	future	future	JJ
10_1101-2020_06_17_156679	185	16	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	185	17	,	,	,
10_1101-2020_06_17_156679	185	18	a	a	DT
10_1101-2020_06_17_156679	185	19	343	343	CD
10_1101-2020_06_17_156679	185	20	high	high	JJ
10_1101-2020_06_17_156679	185	21	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	185	22	value	value	NN
10_1101-2020_06_17_156679	185	23	as	as	RB
10_1101-2020_06_17_156679	185	24	well	well	RB
10_1101-2020_06_17_156679	185	25	as	as	IN
10_1101-2020_06_17_156679	185	26	low	low	JJ
10_1101-2020_06_17_156679	185	27	IC50	IC50	NNP
10_1101-2020_06_17_156679	185	28	parameters	parameter	NNS
10_1101-2020_06_17_156679	185	29	are	be	VBP
10_1101-2020_06_17_156679	185	30	both	both	RB
10_1101-2020_06_17_156679	185	31	desirable	desirable	JJ
10_1101-2020_06_17_156679	185	32	.	.	.
10_1101-2020_06_17_156679	186	1	Second	second	JJ
10_1101-2020_06_17_156679	186	2	,	,	,
10_1101-2020_06_17_156679	186	3	due	due	IN
10_1101-2020_06_17_156679	186	4	to	to	IN
10_1101-2020_06_17_156679	186	5	the	the	DT
10_1101-2020_06_17_156679	186	6	344	344	CD
10_1101-2020_06_17_156679	186	7	aforementioned	aforementioned	JJ
10_1101-2020_06_17_156679	186	8	limitations	limitation	NNS
10_1101-2020_06_17_156679	186	9	of	of	IN
10_1101-2020_06_17_156679	186	10	single	single	JJ
10_1101-2020_06_17_156679	186	11	-	-	HYPH
10_1101-2020_06_17_156679	186	12	concentration	concentration	NN
10_1101-2020_06_17_156679	186	13	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	186	14	value	value	NN
10_1101-2020_06_17_156679	186	15	as	as	IN
10_1101-2020_06_17_156679	186	16	proxy	proxy	NN
10_1101-2020_06_17_156679	186	17	of	of	IN
10_1101-2020_06_17_156679	186	18	affinity	affinity	NN
10_1101-2020_06_17_156679	186	19	,	,	,
10_1101-2020_06_17_156679	186	20	and	and	CC
10_1101-2020_06_17_156679	186	21	the	the	DT
10_1101-2020_06_17_156679	186	22	345	345	CD
10_1101-2020_06_17_156679	186	23	.CC	.CC	,
10_1101-2020_06_17_156679	186	24	-	-	:
10_1101-2020_06_17_156679	186	25	BY	by	IN
10_1101-2020_06_17_156679	186	26	4.0	4.0	CD
10_1101-2020_06_17_156679	186	27	International	International	NNP
10_1101-2020_06_17_156679	186	28	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	186	29	under	under	IN
10_1101-2020_06_17_156679	186	30	a	a	DT
10_1101-2020_06_17_156679	186	31	(	(	-LRB-
10_1101-2020_06_17_156679	186	32	which	which	WDT
10_1101-2020_06_17_156679	186	33	was	be	VBD
10_1101-2020_06_17_156679	186	34	not	not	RB
10_1101-2020_06_17_156679	186	35	certified	certify	VBN
10_1101-2020_06_17_156679	186	36	by	by	IN
10_1101-2020_06_17_156679	186	37	peer	peer	NN
10_1101-2020_06_17_156679	186	38	review	review	NN
10_1101-2020_06_17_156679	186	39	)	)	-RRB-
10_1101-2020_06_17_156679	186	40	is	be	VBZ
10_1101-2020_06_17_156679	186	41	the	the	DT
10_1101-2020_06_17_156679	186	42	author	author	NN
10_1101-2020_06_17_156679	186	43	/	/	SYM
10_1101-2020_06_17_156679	186	44	funder	funder	NN
10_1101-2020_06_17_156679	186	45	,	,	,
10_1101-2020_06_17_156679	186	46	who	who	WP
10_1101-2020_06_17_156679	186	47	has	have	VBZ
10_1101-2020_06_17_156679	186	48	granted	grant	VBN
10_1101-2020_06_17_156679	186	49	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	186	50	a	a	DT
10_1101-2020_06_17_156679	186	51	license	license	NN
10_1101-2020_06_17_156679	186	52	to	to	TO
10_1101-2020_06_17_156679	186	53	display	display	VB
10_1101-2020_06_17_156679	186	54	the	the	DT
10_1101-2020_06_17_156679	186	55	preprint	preprint	NN
10_1101-2020_06_17_156679	186	56	in	in	IN
10_1101-2020_06_17_156679	186	57	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	186	58	.	.	.
10_1101-2020_06_17_156679	187	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	187	2	is	be	VBZ
10_1101-2020_06_17_156679	187	3	made	make	VBN
10_1101-2020_06_17_156679	187	4	The	the	DT
10_1101-2020_06_17_156679	187	5	copyright	copyright	NN
10_1101-2020_06_17_156679	187	6	holder	holder	NN
10_1101-2020_06_17_156679	187	7	for	for	IN
10_1101-2020_06_17_156679	187	8	this	this	DT
10_1101-2020_06_17_156679	187	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	187	10	version	version	NN
10_1101-2020_06_17_156679	187	11	posted	post	VBD
10_1101-2020_06_17_156679	187	12	January	January	NNP
10_1101-2020_06_17_156679	187	13	6	6	CD
10_1101-2020_06_17_156679	187	14	,	,	,
10_1101-2020_06_17_156679	187	15	2021	2021	CD
10_1101-2020_06_17_156679	187	16	.	.	.
10_1101-2020_06_17_156679	187	17	;	;	:
10_1101-2020_06_17_156679	187	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	187	19	:	:	:
10_1101-2020_06_17_156679	187	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	187	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	187	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	187	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	187	24	13	13	CD
10_1101-2020_06_17_156679	187	25	influence	influence	NN
10_1101-2020_06_17_156679	187	26	of	of	IN
10_1101-2020_06_17_156679	187	27	uncertainties	uncertainty	NNS
10_1101-2020_06_17_156679	187	28	in	in	IN
10_1101-2020_06_17_156679	187	29	ligand	ligand	NN
10_1101-2020_06_17_156679	187	30	concentrations	concentration	NNS
10_1101-2020_06_17_156679	187	31	,	,	,
10_1101-2020_06_17_156679	187	32	we	-PRON-	PRP
10_1101-2020_06_17_156679	187	33	believe	believe	VBP
10_1101-2020_06_17_156679	187	34	that	that	IN
10_1101-2020_06_17_156679	187	35	comparisons	comparison	NNS
10_1101-2020_06_17_156679	187	36	of	of	IN
10_1101-2020_06_17_156679	187	37	compounds	compound	NNS
10_1101-2020_06_17_156679	187	38	and	and	CC
10_1101-2020_06_17_156679	187	39	346	346	CD
10_1101-2020_06_17_156679	187	40	derivatives	derivative	NNS
10_1101-2020_06_17_156679	187	41	differing	differ	VBG
10_1101-2020_06_17_156679	187	42	by	by	IN
10_1101-2020_06_17_156679	187	43	less	less	JJR
10_1101-2020_06_17_156679	187	44	than	than	IN
10_1101-2020_06_17_156679	187	45	~50	~50	CD
10_1101-2020_06_17_156679	187	46	%	%	NN
10_1101-2020_06_17_156679	187	47	in	in	IN
10_1101-2020_06_17_156679	187	48	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	187	49	is	be	VBZ
10_1101-2020_06_17_156679	187	50	not	not	RB
10_1101-2020_06_17_156679	187	51	meaningful	meaningful	JJ
10_1101-2020_06_17_156679	187	52	.	.	.
10_1101-2020_06_17_156679	188	1	Rather	rather	RB
10_1101-2020_06_17_156679	188	2	,	,	,
10_1101-2020_06_17_156679	188	3	we	-PRON-	PRP
10_1101-2020_06_17_156679	188	4	propose	propose	VBP
10_1101-2020_06_17_156679	188	5	that	that	IN
10_1101-2020_06_17_156679	188	6	the	the	DT
10_1101-2020_06_17_156679	188	7	347	347	CD
10_1101-2020_06_17_156679	188	8	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	188	9	values	value	NNS
10_1101-2020_06_17_156679	188	10	of	of	IN
10_1101-2020_06_17_156679	188	11	M	m	NN
10_1101-2020_06_17_156679	188	12	pro	pro	JJ
10_1101-2020_06_17_156679	188	13	ligands	ligand	VBZ
10_1101-2020_06_17_156679	188	14	measured	measured	JJ
10_1101-2020_06_17_156679	188	15	and	and	CC
10_1101-2020_06_17_156679	188	16	available	available	JJ
10_1101-2020_06_17_156679	188	17	at	at	IN
10_1101-2020_06_17_156679	188	18	the	the	DT
10_1101-2020_06_17_156679	188	19	CDD	CDD	NNP
10_1101-2020_06_17_156679	188	20	database	database	NN
10_1101-2020_06_17_156679	188	21	should	should	MD
10_1101-2020_06_17_156679	188	22	be	be	VB
10_1101-2020_06_17_156679	188	23	treated	treat	VBN
10_1101-2020_06_17_156679	188	24	as	as	IN
10_1101-2020_06_17_156679	188	25	a	a	DT
10_1101-2020_06_17_156679	188	26	348	348	CD
10_1101-2020_06_17_156679	188	27	qualitative	qualitative	JJ
10_1101-2020_06_17_156679	188	28	metrics	metric	NNS
10_1101-2020_06_17_156679	188	29	of	of	IN
10_1101-2020_06_17_156679	188	30	compound	compound	NN
10_1101-2020_06_17_156679	188	31	affinity	affinity	NN
10_1101-2020_06_17_156679	188	32	.	.	.
10_1101-2020_06_17_156679	189	1	349	349	CD
10_1101-2020_06_17_156679	189	2	In	in	IN
10_1101-2020_06_17_156679	189	3	conclusion	conclusion	NN
10_1101-2020_06_17_156679	189	4	,	,	,
10_1101-2020_06_17_156679	189	5	we	-PRON-	PRP
10_1101-2020_06_17_156679	189	6	presented	present	VBD
10_1101-2020_06_17_156679	189	7	here	here	RB
10_1101-2020_06_17_156679	189	8	protocols	protocol	NNS
10_1101-2020_06_17_156679	189	9	for	for	IN
10_1101-2020_06_17_156679	189	10	the	the	DT
10_1101-2020_06_17_156679	189	11	assessment	assessment	NN
10_1101-2020_06_17_156679	189	12	of	of	IN
10_1101-2020_06_17_156679	189	13	SARS	SARS	NNP
10_1101-2020_06_17_156679	189	14	-	-	HYPH
10_1101-2020_06_17_156679	189	15	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	189	16	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	189	17	ligands	ligand	VBZ
10_1101-2020_06_17_156679	189	18	using	use	VBG
10_1101-2020_06_17_156679	189	19	350	350	CD
10_1101-2020_06_17_156679	189	20	STD	STD	NNP
10_1101-2020_06_17_156679	189	21	-	-	HYPH
10_1101-2020_06_17_156679	189	22	NMR	NMR	NNP
10_1101-2020_06_17_156679	189	23	spectroscopy	spectroscopy	NN
10_1101-2020_06_17_156679	189	24	,	,	,
10_1101-2020_06_17_156679	189	25	and	and	CC
10_1101-2020_06_17_156679	189	26	evaluated	evaluate	VBD
10_1101-2020_06_17_156679	189	27	the	the	DT
10_1101-2020_06_17_156679	189	28	relative	relative	JJ
10_1101-2020_06_17_156679	189	29	qualitative	qualitative	JJ
10_1101-2020_06_17_156679	189	30	affinities	affinity	NNS
10_1101-2020_06_17_156679	189	31	of	of	IN
10_1101-2020_06_17_156679	189	32	chemical	chemical	NN
10_1101-2020_06_17_156679	189	33	fragments	fragment	NNS
10_1101-2020_06_17_156679	189	34	and	and	CC
10_1101-2020_06_17_156679	189	35	351	351	CD
10_1101-2020_06_17_156679	189	36	compounds	compound	NNS
10_1101-2020_06_17_156679	189	37	designed	design	VBN
10_1101-2020_06_17_156679	189	38	as	as	IN
10_1101-2020_06_17_156679	189	39	part	part	NN
10_1101-2020_06_17_156679	189	40	of	of	IN
10_1101-2020_06_17_156679	189	41	COVID	COVID	NNP
10_1101-2020_06_17_156679	189	42	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	189	43	.	.	.
10_1101-2020_06_17_156679	190	1	Although	although	IN
10_1101-2020_06_17_156679	190	2	development	development	NN
10_1101-2020_06_17_156679	190	3	of	of	IN
10_1101-2020_06_17_156679	190	4	novel	novel	JJ
10_1101-2020_06_17_156679	190	5	antivirals	antiviral	NNS
10_1101-2020_06_17_156679	190	6	to	to	IN
10_1101-2020_06_17_156679	190	7	352	352	CD
10_1101-2020_06_17_156679	190	8	combat	combat	NN
10_1101-2020_06_17_156679	190	9	COVID-19	COVID-19	,
10_1101-2020_06_17_156679	190	10	is	be	VBZ
10_1101-2020_06_17_156679	190	11	still	still	RB
10_1101-2020_06_17_156679	190	12	at	at	IN
10_1101-2020_06_17_156679	190	13	an	an	DT
10_1101-2020_06_17_156679	190	14	early	early	JJ
10_1101-2020_06_17_156679	190	15	stage	stage	NN
10_1101-2020_06_17_156679	190	16	,	,	,
10_1101-2020_06_17_156679	190	17	we	-PRON-	PRP
10_1101-2020_06_17_156679	190	18	hope	hope	VBP
10_1101-2020_06_17_156679	190	19	that	that	IN
10_1101-2020_06_17_156679	190	20	this	this	DT
10_1101-2020_06_17_156679	190	21	information	information	NN
10_1101-2020_06_17_156679	190	22	will	will	MD
10_1101-2020_06_17_156679	190	23	prove	prove	VB
10_1101-2020_06_17_156679	190	24	valuable	valuable	JJ
10_1101-2020_06_17_156679	190	25	to	to	IN
10_1101-2020_06_17_156679	190	26	353	353	CD
10_1101-2020_06_17_156679	190	27	groups	group	NNS
10_1101-2020_06_17_156679	190	28	working	work	VBG
10_1101-2020_06_17_156679	190	29	towards	towards	IN
10_1101-2020_06_17_156679	190	30	such	such	JJ
10_1101-2020_06_17_156679	190	31	treatments	treatment	NNS
10_1101-2020_06_17_156679	190	32	.	.	.
10_1101-2020_06_17_156679	191	1	354	354	CD
10_1101-2020_06_17_156679	191	2	355	355	CD
10_1101-2020_06_17_156679	191	3	.CC	.CC	:
10_1101-2020_06_17_156679	191	4	-	-	:
10_1101-2020_06_17_156679	191	5	BY	by	IN
10_1101-2020_06_17_156679	191	6	4.0	4.0	CD
10_1101-2020_06_17_156679	191	7	International	International	NNP
10_1101-2020_06_17_156679	191	8	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	191	9	under	under	IN
10_1101-2020_06_17_156679	191	10	a	a	DT
10_1101-2020_06_17_156679	191	11	(	(	-LRB-
10_1101-2020_06_17_156679	191	12	which	which	WDT
10_1101-2020_06_17_156679	191	13	was	be	VBD
10_1101-2020_06_17_156679	191	14	not	not	RB
10_1101-2020_06_17_156679	191	15	certified	certify	VBN
10_1101-2020_06_17_156679	191	16	by	by	IN
10_1101-2020_06_17_156679	191	17	peer	peer	NN
10_1101-2020_06_17_156679	191	18	review	review	NN
10_1101-2020_06_17_156679	191	19	)	)	-RRB-
10_1101-2020_06_17_156679	191	20	is	be	VBZ
10_1101-2020_06_17_156679	191	21	the	the	DT
10_1101-2020_06_17_156679	191	22	author	author	NN
10_1101-2020_06_17_156679	191	23	/	/	SYM
10_1101-2020_06_17_156679	191	24	funder	funder	NN
10_1101-2020_06_17_156679	191	25	,	,	,
10_1101-2020_06_17_156679	191	26	who	who	WP
10_1101-2020_06_17_156679	191	27	has	have	VBZ
10_1101-2020_06_17_156679	191	28	granted	grant	VBN
10_1101-2020_06_17_156679	191	29	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	191	30	a	a	DT
10_1101-2020_06_17_156679	191	31	license	license	NN
10_1101-2020_06_17_156679	191	32	to	to	TO
10_1101-2020_06_17_156679	191	33	display	display	VB
10_1101-2020_06_17_156679	191	34	the	the	DT
10_1101-2020_06_17_156679	191	35	preprint	preprint	NN
10_1101-2020_06_17_156679	191	36	in	in	IN
10_1101-2020_06_17_156679	191	37	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	191	38	.	.	.
10_1101-2020_06_17_156679	192	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	192	2	is	be	VBZ
10_1101-2020_06_17_156679	192	3	made	make	VBN
10_1101-2020_06_17_156679	192	4	The	the	DT
10_1101-2020_06_17_156679	192	5	copyright	copyright	NN
10_1101-2020_06_17_156679	192	6	holder	holder	NN
10_1101-2020_06_17_156679	192	7	for	for	IN
10_1101-2020_06_17_156679	192	8	this	this	DT
10_1101-2020_06_17_156679	192	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	192	10	version	version	NN
10_1101-2020_06_17_156679	192	11	posted	post	VBD
10_1101-2020_06_17_156679	192	12	January	January	NNP
10_1101-2020_06_17_156679	192	13	6	6	CD
10_1101-2020_06_17_156679	192	14	,	,	,
10_1101-2020_06_17_156679	192	15	2021	2021	CD
10_1101-2020_06_17_156679	192	16	.	.	.
10_1101-2020_06_17_156679	192	17	;	;	:
10_1101-2020_06_17_156679	192	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	192	19	:	:	:
10_1101-2020_06_17_156679	192	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	192	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	192	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	192	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	192	24	14	14	CD
10_1101-2020_06_17_156679	192	25	References	reference	NNS
10_1101-2020_06_17_156679	192	26	356	356	CD
10_1101-2020_06_17_156679	192	27	1	1	CD
10_1101-2020_06_17_156679	192	28	.	.	.
10_1101-2020_06_17_156679	192	29	WHO	who	WP
10_1101-2020_06_17_156679	192	30	.	.	.
10_1101-2020_06_17_156679	193	1	Coronavirus	Coronavirus	NNP
10_1101-2020_06_17_156679	193	2	disease	disease	NNP
10_1101-2020_06_17_156679	193	3	2019	2019	CD
10_1101-2020_06_17_156679	193	4	[	[	-LRB-
10_1101-2020_06_17_156679	193	5	Available	available	JJ
10_1101-2020_06_17_156679	193	6	from	from	IN
10_1101-2020_06_17_156679	193	7	:	:	:
10_1101-2020_06_17_156679	193	8	357	357	CD
10_1101-2020_06_17_156679	193	9	https://www.who.int/emergencies/diseases/novel-coronavirus-2019	https://www.who.int/emergencies/diseases/novel-coronavirus-2019	NNS
10_1101-2020_06_17_156679	193	10	.	.	.
10_1101-2020_06_17_156679	194	1	358	358	CD
10_1101-2020_06_17_156679	194	2	2	2	CD
10_1101-2020_06_17_156679	194	3	.	.	.
10_1101-2020_06_17_156679	195	1	Kucharski	Kucharski	NNP
10_1101-2020_06_17_156679	195	2	AJ	AJ	NNP
10_1101-2020_06_17_156679	195	3	,	,	,
10_1101-2020_06_17_156679	195	4	Russell	Russell	NNP
10_1101-2020_06_17_156679	195	5	TW	TW	NNP
10_1101-2020_06_17_156679	195	6	,	,	,
10_1101-2020_06_17_156679	195	7	Diamond	Diamond	NNP
10_1101-2020_06_17_156679	195	8	C	C	NNP
10_1101-2020_06_17_156679	195	9	,	,	,
10_1101-2020_06_17_156679	195	10	Liu	Liu	NNP
10_1101-2020_06_17_156679	195	11	Y	Y	NNP
10_1101-2020_06_17_156679	195	12	,	,	,
10_1101-2020_06_17_156679	195	13	Edmunds	Edmunds	NNP
10_1101-2020_06_17_156679	195	14	J	J	NNP
10_1101-2020_06_17_156679	195	15	,	,	,
10_1101-2020_06_17_156679	195	16	Funk	Funk	NNP
10_1101-2020_06_17_156679	195	17	S	S	NNP
10_1101-2020_06_17_156679	195	18	,	,	,
10_1101-2020_06_17_156679	195	19	et	et	NNP
10_1101-2020_06_17_156679	195	20	al	al	NNP
10_1101-2020_06_17_156679	195	21	.	.	.
10_1101-2020_06_17_156679	196	1	Early	early	JJ
10_1101-2020_06_17_156679	196	2	dynamics	dynamic	NNS
10_1101-2020_06_17_156679	196	3	of	of	IN
10_1101-2020_06_17_156679	196	4	359	359	CD
10_1101-2020_06_17_156679	196	5	transmission	transmission	NN
10_1101-2020_06_17_156679	196	6	and	and	CC
10_1101-2020_06_17_156679	196	7	control	control	NN
10_1101-2020_06_17_156679	196	8	of	of	IN
10_1101-2020_06_17_156679	196	9	COVID-19	COVID-19	NNP
10_1101-2020_06_17_156679	196	10	:	:	:
10_1101-2020_06_17_156679	196	11	a	a	DT
10_1101-2020_06_17_156679	196	12	mathematical	mathematical	JJ
10_1101-2020_06_17_156679	196	13	modelling	modelling	NN
10_1101-2020_06_17_156679	196	14	study	study	NN
10_1101-2020_06_17_156679	196	15	.	.	.
10_1101-2020_06_17_156679	197	1	Lancet	Lancet	NNP
10_1101-2020_06_17_156679	197	2	Infect	Infect	NNP
10_1101-2020_06_17_156679	197	3	Dis	Dis	NNP
10_1101-2020_06_17_156679	197	4	.	.	.
10_1101-2020_06_17_156679	198	1	360	360	CD
10_1101-2020_06_17_156679	198	2	2020;20(5):553	2020;20(5):553	CD
10_1101-2020_06_17_156679	198	3	-	-	SYM
10_1101-2020_06_17_156679	198	4	8	8	CD
10_1101-2020_06_17_156679	198	5	.	.	.
10_1101-2020_06_17_156679	199	1	361	361	CD
10_1101-2020_06_17_156679	199	2	3	3	CD
10_1101-2020_06_17_156679	199	3	.	.	.
10_1101-2020_06_17_156679	200	1	Wu	Wu	NNP
10_1101-2020_06_17_156679	200	2	F	F	NNP
10_1101-2020_06_17_156679	200	3	,	,	,
10_1101-2020_06_17_156679	200	4	Zhao	Zhao	NNP
10_1101-2020_06_17_156679	200	5	S	S	NNP
10_1101-2020_06_17_156679	200	6	,	,	,
10_1101-2020_06_17_156679	200	7	Yu	Yu	NNP
10_1101-2020_06_17_156679	200	8	B	B	NNP
10_1101-2020_06_17_156679	200	9	,	,	,
10_1101-2020_06_17_156679	200	10	Chen	Chen	NNP
10_1101-2020_06_17_156679	200	11	YM	YM	NNP
10_1101-2020_06_17_156679	200	12	,	,	,
10_1101-2020_06_17_156679	200	13	Wang	Wang	NNP
10_1101-2020_06_17_156679	200	14	W	W	NNP
10_1101-2020_06_17_156679	200	15	,	,	,
10_1101-2020_06_17_156679	200	16	Song	Song	NNP
10_1101-2020_06_17_156679	200	17	ZG	ZG	NNP
10_1101-2020_06_17_156679	200	18	,	,	,
10_1101-2020_06_17_156679	200	19	et	et	NNP
10_1101-2020_06_17_156679	200	20	al	al	NNP
10_1101-2020_06_17_156679	200	21	.	.	.
10_1101-2020_06_17_156679	201	1	A	a	DT
10_1101-2020_06_17_156679	201	2	new	new	JJ
10_1101-2020_06_17_156679	201	3	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	201	4	associated	associate	VBN
10_1101-2020_06_17_156679	201	5	with	with	IN
10_1101-2020_06_17_156679	201	6	362	362	CD
10_1101-2020_06_17_156679	201	7	human	human	JJ
10_1101-2020_06_17_156679	201	8	respiratory	respiratory	JJ
10_1101-2020_06_17_156679	201	9	disease	disease	NN
10_1101-2020_06_17_156679	201	10	in	in	IN
10_1101-2020_06_17_156679	201	11	China	China	NNP
10_1101-2020_06_17_156679	201	12	.	.	.
10_1101-2020_06_17_156679	202	1	Nature	nature	NN
10_1101-2020_06_17_156679	202	2	.	.	.
10_1101-2020_06_17_156679	203	1	2020;579(7798):265	2020;579(7798):265	CD
10_1101-2020_06_17_156679	203	2	-	-	SYM
10_1101-2020_06_17_156679	203	3	9	9	CD
10_1101-2020_06_17_156679	203	4	.	.	.
10_1101-2020_06_17_156679	204	1	363	363	CD
10_1101-2020_06_17_156679	204	2	4	4	CD
10_1101-2020_06_17_156679	204	3	.	.	.
10_1101-2020_06_17_156679	205	1	Zhu	Zhu	NNP
10_1101-2020_06_17_156679	205	2	N	N	NNP
10_1101-2020_06_17_156679	205	3	,	,	,
10_1101-2020_06_17_156679	205	4	Zhang	Zhang	NNP
10_1101-2020_06_17_156679	205	5	D	D	NNP
10_1101-2020_06_17_156679	205	6	,	,	,
10_1101-2020_06_17_156679	205	7	Wang	Wang	NNP
10_1101-2020_06_17_156679	205	8	W	W	NNP
10_1101-2020_06_17_156679	205	9	,	,	,
10_1101-2020_06_17_156679	205	10	Li	Li	NNP
10_1101-2020_06_17_156679	205	11	X	X	NNP
10_1101-2020_06_17_156679	205	12	,	,	,
10_1101-2020_06_17_156679	205	13	Yang	Yang	NNP
10_1101-2020_06_17_156679	205	14	B	B	NNP
10_1101-2020_06_17_156679	205	15	,	,	,
10_1101-2020_06_17_156679	205	16	Song	Song	NNP
10_1101-2020_06_17_156679	205	17	J	J	NNP
10_1101-2020_06_17_156679	205	18	,	,	,
10_1101-2020_06_17_156679	205	19	et	et	NNP
10_1101-2020_06_17_156679	205	20	al	al	NNP
10_1101-2020_06_17_156679	205	21	.	.	.
10_1101-2020_06_17_156679	206	1	A	a	DT
10_1101-2020_06_17_156679	206	2	Novel	novel	JJ
10_1101-2020_06_17_156679	206	3	Coronavirus	Coronavirus	NNP
10_1101-2020_06_17_156679	206	4	from	from	IN
10_1101-2020_06_17_156679	206	5	Patients	Patients	NNPS
10_1101-2020_06_17_156679	206	6	with	with	IN
10_1101-2020_06_17_156679	206	7	364	364	CD
10_1101-2020_06_17_156679	206	8	Pneumonia	Pneumonia	NNP
10_1101-2020_06_17_156679	206	9	in	in	IN
10_1101-2020_06_17_156679	206	10	China	China	NNP
10_1101-2020_06_17_156679	206	11	,	,	,
10_1101-2020_06_17_156679	206	12	2019	2019	CD
10_1101-2020_06_17_156679	206	13	.	.	.
10_1101-2020_06_17_156679	207	1	N	N	NNP
10_1101-2020_06_17_156679	207	2	Engl	Engl	NNP
10_1101-2020_06_17_156679	207	3	J	J	NNP
10_1101-2020_06_17_156679	207	4	Med	Med	NNP
10_1101-2020_06_17_156679	207	5	.	.	.
10_1101-2020_06_17_156679	208	1	2020;382(8):727	2020;382(8):727	NNP
10_1101-2020_06_17_156679	208	2	-	-	:
10_1101-2020_06_17_156679	208	3	33	33	CD
10_1101-2020_06_17_156679	208	4	.	.	.
10_1101-2020_06_17_156679	209	1	365	365	CD
10_1101-2020_06_17_156679	209	2	5	5	CD
10_1101-2020_06_17_156679	209	3	.	.	.
10_1101-2020_06_17_156679	210	1	Bermingham	Bermingham	NNP
10_1101-2020_06_17_156679	210	2	A	A	NNP
10_1101-2020_06_17_156679	210	3	,	,	,
10_1101-2020_06_17_156679	210	4	Chand	Chand	NNP
10_1101-2020_06_17_156679	210	5	MA	MA	NNP
10_1101-2020_06_17_156679	210	6	,	,	,
10_1101-2020_06_17_156679	210	7	Brown	Brown	NNP
10_1101-2020_06_17_156679	210	8	CS	CS	NNP
10_1101-2020_06_17_156679	210	9	,	,	,
10_1101-2020_06_17_156679	210	10	Aarons	Aarons	NNP
10_1101-2020_06_17_156679	210	11	E	E	NNP
10_1101-2020_06_17_156679	210	12	,	,	,
10_1101-2020_06_17_156679	210	13	Tong	Tong	NNP
10_1101-2020_06_17_156679	210	14	C	C	NNP
10_1101-2020_06_17_156679	210	15	,	,	,
10_1101-2020_06_17_156679	210	16	Langrish	Langrish	NNP
10_1101-2020_06_17_156679	210	17	C	C	NNP
10_1101-2020_06_17_156679	210	18	,	,	,
10_1101-2020_06_17_156679	210	19	et	et	NNP
10_1101-2020_06_17_156679	210	20	al	al	NNP
10_1101-2020_06_17_156679	210	21	.	.	.
10_1101-2020_06_17_156679	211	1	Severe	severe	JJ
10_1101-2020_06_17_156679	211	2	respiratory	respiratory	JJ
10_1101-2020_06_17_156679	211	3	366	366	CD
10_1101-2020_06_17_156679	211	4	illness	illness	NN
10_1101-2020_06_17_156679	211	5	caused	cause	VBN
10_1101-2020_06_17_156679	211	6	by	by	IN
10_1101-2020_06_17_156679	211	7	a	a	DT
10_1101-2020_06_17_156679	211	8	novel	novel	JJ
10_1101-2020_06_17_156679	211	9	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	211	10	,	,	,
10_1101-2020_06_17_156679	211	11	in	in	IN
10_1101-2020_06_17_156679	211	12	a	a	DT
10_1101-2020_06_17_156679	211	13	patient	patient	NN
10_1101-2020_06_17_156679	211	14	transferred	transfer	VBN
10_1101-2020_06_17_156679	211	15	to	to	IN
10_1101-2020_06_17_156679	211	16	the	the	DT
10_1101-2020_06_17_156679	211	17	United	United	NNP
10_1101-2020_06_17_156679	211	18	Kingdom	Kingdom	NNP
10_1101-2020_06_17_156679	211	19	from	from	IN
10_1101-2020_06_17_156679	211	20	the	the	DT
10_1101-2020_06_17_156679	211	21	367	367	CD
10_1101-2020_06_17_156679	211	22	Middle	Middle	NNP
10_1101-2020_06_17_156679	211	23	East	East	NNP
10_1101-2020_06_17_156679	211	24	,	,	,
10_1101-2020_06_17_156679	211	25	September	September	NNP
10_1101-2020_06_17_156679	211	26	2012	2012	CD
10_1101-2020_06_17_156679	211	27	.	.	.
10_1101-2020_06_17_156679	212	1	Euro	Euro	NNP
10_1101-2020_06_17_156679	212	2	Surveill	Surveill	NNP
10_1101-2020_06_17_156679	212	3	.	.	.
10_1101-2020_06_17_156679	213	1	2012;17(40):20290	2012;17(40):20290	CD
10_1101-2020_06_17_156679	213	2	.	.	.
10_1101-2020_06_17_156679	214	1	368	368	CD
10_1101-2020_06_17_156679	214	2	6	6	CD
10_1101-2020_06_17_156679	214	3	.	.	.
10_1101-2020_06_17_156679	215	1	Kuiken	Kuiken	NNP
10_1101-2020_06_17_156679	215	2	T	T	NNP
10_1101-2020_06_17_156679	215	3	,	,	,
10_1101-2020_06_17_156679	215	4	Fouchier	Fouchier	NNP
10_1101-2020_06_17_156679	215	5	RA	RA	NNP
10_1101-2020_06_17_156679	215	6	,	,	,
10_1101-2020_06_17_156679	215	7	Schutten	Schutten	NNP
10_1101-2020_06_17_156679	215	8	M	M	NNP
10_1101-2020_06_17_156679	215	9	,	,	,
10_1101-2020_06_17_156679	215	10	Rimmelzwaan	Rimmelzwaan	NNP
10_1101-2020_06_17_156679	215	11	GF	GF	NNP
10_1101-2020_06_17_156679	215	12	,	,	,
10_1101-2020_06_17_156679	215	13	van	van	NNP
10_1101-2020_06_17_156679	215	14	Amerongen	Amerongen	NNP
10_1101-2020_06_17_156679	215	15	G	G	NNP
10_1101-2020_06_17_156679	215	16	,	,	,
10_1101-2020_06_17_156679	215	17	van	van	NNP
10_1101-2020_06_17_156679	215	18	Riel	Riel	NNP
10_1101-2020_06_17_156679	215	19	D	D	NNP
10_1101-2020_06_17_156679	215	20	,	,	,
10_1101-2020_06_17_156679	215	21	et	et	NNP
10_1101-2020_06_17_156679	215	22	al	al	NNP
10_1101-2020_06_17_156679	215	23	.	.	.
10_1101-2020_06_17_156679	216	1	369	369	CD
10_1101-2020_06_17_156679	216	2	Newly	newly	RB
10_1101-2020_06_17_156679	216	3	discovered	discover	VBN
10_1101-2020_06_17_156679	216	4	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	216	5	as	as	IN
10_1101-2020_06_17_156679	216	6	the	the	DT
10_1101-2020_06_17_156679	216	7	primary	primary	JJ
10_1101-2020_06_17_156679	216	8	cause	cause	NN
10_1101-2020_06_17_156679	216	9	of	of	IN
10_1101-2020_06_17_156679	216	10	severe	severe	JJ
10_1101-2020_06_17_156679	216	11	acute	acute	JJ
10_1101-2020_06_17_156679	216	12	respiratory	respiratory	JJ
10_1101-2020_06_17_156679	216	13	syndrome	syndrome	NN
10_1101-2020_06_17_156679	216	14	.	.	.
10_1101-2020_06_17_156679	217	1	Lancet	Lancet	NNP
10_1101-2020_06_17_156679	217	2	.	.	.
10_1101-2020_06_17_156679	218	1	370	370	CD
10_1101-2020_06_17_156679	218	2	2003;362(9380):263	2003;362(9380):263	CD
10_1101-2020_06_17_156679	218	3	-	-	SYM
10_1101-2020_06_17_156679	218	4	70	70	CD
10_1101-2020_06_17_156679	218	5	.	.	.
10_1101-2020_06_17_156679	219	1	371	371	CD
10_1101-2020_06_17_156679	219	2	7	7	CD
10_1101-2020_06_17_156679	219	3	.	.	.
10_1101-2020_06_17_156679	220	1	Zaki	Zaki	NNP
10_1101-2020_06_17_156679	220	2	AM	AM	NNP
10_1101-2020_06_17_156679	220	3	,	,	,
10_1101-2020_06_17_156679	220	4	van	van	NNP
10_1101-2020_06_17_156679	220	5	Boheemen	Boheemen	NNP
10_1101-2020_06_17_156679	220	6	S	S	NNP
10_1101-2020_06_17_156679	220	7	,	,	,
10_1101-2020_06_17_156679	220	8	Bestebroer	Bestebroer	NNP
10_1101-2020_06_17_156679	220	9	TM	TM	NNP
10_1101-2020_06_17_156679	220	10	,	,	,
10_1101-2020_06_17_156679	220	11	Osterhaus	Osterhaus	NNP
10_1101-2020_06_17_156679	220	12	AD	AD	NNP
10_1101-2020_06_17_156679	220	13	,	,	,
10_1101-2020_06_17_156679	220	14	Fouchier	Fouchier	NNP
10_1101-2020_06_17_156679	220	15	RA	RA	NNP
10_1101-2020_06_17_156679	220	16	.	.	.
10_1101-2020_06_17_156679	221	1	Isolation	isolation	NN
10_1101-2020_06_17_156679	221	2	of	of	IN
10_1101-2020_06_17_156679	221	3	a	a	DT
10_1101-2020_06_17_156679	221	4	novel	novel	JJ
10_1101-2020_06_17_156679	221	5	372	372	CD
10_1101-2020_06_17_156679	221	6	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	221	7	from	from	IN
10_1101-2020_06_17_156679	221	8	a	a	DT
10_1101-2020_06_17_156679	221	9	man	man	NN
10_1101-2020_06_17_156679	221	10	with	with	IN
10_1101-2020_06_17_156679	221	11	pneumonia	pneumonia	NN
10_1101-2020_06_17_156679	221	12	in	in	IN
10_1101-2020_06_17_156679	221	13	Saudi	Saudi	NNP
10_1101-2020_06_17_156679	221	14	Arabia	Arabia	NNP
10_1101-2020_06_17_156679	221	15	.	.	.
10_1101-2020_06_17_156679	222	1	N	N	NNP
10_1101-2020_06_17_156679	222	2	Engl	Engl	NNP
10_1101-2020_06_17_156679	222	3	J	J	NNP
10_1101-2020_06_17_156679	222	4	Med	Med	NNP
10_1101-2020_06_17_156679	222	5	.	.	.
10_1101-2020_06_17_156679	223	1	2012;367(19):1814	2012;367(19):1814	CD
10_1101-2020_06_17_156679	223	2	-	-	SYM
10_1101-2020_06_17_156679	223	3	20	20	CD
10_1101-2020_06_17_156679	223	4	.	.	.
10_1101-2020_06_17_156679	224	1	373	373	CD
10_1101-2020_06_17_156679	224	2	8	8	CD
10_1101-2020_06_17_156679	224	3	.	.	.
10_1101-2020_06_17_156679	225	1	Thiel	Thiel	NNP
10_1101-2020_06_17_156679	225	2	V	V	NNP
10_1101-2020_06_17_156679	225	3	,	,	,
10_1101-2020_06_17_156679	225	4	Ivanov	Ivanov	NNP
10_1101-2020_06_17_156679	225	5	KA	KA	NNP
10_1101-2020_06_17_156679	225	6	,	,	,
10_1101-2020_06_17_156679	225	7	Putics	Putics	NNP
10_1101-2020_06_17_156679	225	8	A	A	NNP
10_1101-2020_06_17_156679	225	9	,	,	,
10_1101-2020_06_17_156679	225	10	Hertzig	Hertzig	NNP
10_1101-2020_06_17_156679	225	11	T	T	NNP
10_1101-2020_06_17_156679	225	12	,	,	,
10_1101-2020_06_17_156679	225	13	Schelle	Schelle	NNP
10_1101-2020_06_17_156679	225	14	B	B	NNP
10_1101-2020_06_17_156679	225	15	,	,	,
10_1101-2020_06_17_156679	225	16	Bayer	Bayer	NNP
10_1101-2020_06_17_156679	225	17	S	S	NNP
10_1101-2020_06_17_156679	225	18	,	,	,
10_1101-2020_06_17_156679	225	19	et	et	NNP
10_1101-2020_06_17_156679	225	20	al	al	NNP
10_1101-2020_06_17_156679	225	21	.	.	.
10_1101-2020_06_17_156679	226	1	Mechanisms	mechanism	NNS
10_1101-2020_06_17_156679	226	2	and	and	CC
10_1101-2020_06_17_156679	226	3	enzymes	enzyme	VBZ
10_1101-2020_06_17_156679	226	4	374	374	CD
10_1101-2020_06_17_156679	226	5	involved	involve	VBN
10_1101-2020_06_17_156679	226	6	in	in	IN
10_1101-2020_06_17_156679	226	7	SARS	SARS	NNP
10_1101-2020_06_17_156679	226	8	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	226	9	genome	genome	JJ
10_1101-2020_06_17_156679	226	10	expression	expression	NN
10_1101-2020_06_17_156679	226	11	.	.	.
10_1101-2020_06_17_156679	227	1	J	J	NNP
10_1101-2020_06_17_156679	227	2	Gen	Gen	NNP
10_1101-2020_06_17_156679	227	3	Virol	Virol	NNP
10_1101-2020_06_17_156679	227	4	.	.	.
10_1101-2020_06_17_156679	228	1	2003;84(Pt	2003;84(Pt	NNP
10_1101-2020_06_17_156679	228	2	9):2305	9):2305	CD
10_1101-2020_06_17_156679	228	3	-	-	SYM
10_1101-2020_06_17_156679	228	4	15	15	CD
10_1101-2020_06_17_156679	228	5	.	.	.
10_1101-2020_06_17_156679	229	1	375	375	CD
10_1101-2020_06_17_156679	229	2	9	9	CD
10_1101-2020_06_17_156679	229	3	.	.	.
10_1101-2020_06_17_156679	230	1	Bredenbeek	bredenbeek	JJ
10_1101-2020_06_17_156679	230	2	PJ	PJ	NNP
10_1101-2020_06_17_156679	230	3	,	,	,
10_1101-2020_06_17_156679	230	4	Pachuk	Pachuk	NNP
10_1101-2020_06_17_156679	230	5	CJ	CJ	NNP
10_1101-2020_06_17_156679	230	6	,	,	,
10_1101-2020_06_17_156679	230	7	Noten	Noten	NNP
10_1101-2020_06_17_156679	230	8	AF	AF	NNP
10_1101-2020_06_17_156679	230	9	,	,	,
10_1101-2020_06_17_156679	230	10	Charite	Charite	NNP
10_1101-2020_06_17_156679	230	11	J	J	NNP
10_1101-2020_06_17_156679	230	12	,	,	,
10_1101-2020_06_17_156679	230	13	Luytjes	Luytjes	NNP
10_1101-2020_06_17_156679	230	14	W	W	NNP
10_1101-2020_06_17_156679	230	15	,	,	,
10_1101-2020_06_17_156679	230	16	Weiss	Weiss	NNP
10_1101-2020_06_17_156679	230	17	SR	SR	NNP
10_1101-2020_06_17_156679	230	18	,	,	,
10_1101-2020_06_17_156679	230	19	et	et	NNP
10_1101-2020_06_17_156679	230	20	al	al	NNP
10_1101-2020_06_17_156679	230	21	.	.	.
10_1101-2020_06_17_156679	231	1	The	the	DT
10_1101-2020_06_17_156679	231	2	primary	primary	JJ
10_1101-2020_06_17_156679	231	3	376	376	CD
10_1101-2020_06_17_156679	231	4	structure	structure	NN
10_1101-2020_06_17_156679	231	5	and	and	CC
10_1101-2020_06_17_156679	231	6	expression	expression	NN
10_1101-2020_06_17_156679	231	7	of	of	IN
10_1101-2020_06_17_156679	231	8	the	the	DT
10_1101-2020_06_17_156679	231	9	second	second	JJ
10_1101-2020_06_17_156679	231	10	open	open	JJ
10_1101-2020_06_17_156679	231	11	reading	reading	NN
10_1101-2020_06_17_156679	231	12	frame	frame	NN
10_1101-2020_06_17_156679	231	13	of	of	IN
10_1101-2020_06_17_156679	231	14	the	the	DT
10_1101-2020_06_17_156679	231	15	polymerase	polymerase	NN
10_1101-2020_06_17_156679	231	16	gene	gene	NN
10_1101-2020_06_17_156679	231	17	of	of	IN
10_1101-2020_06_17_156679	231	18	the	the	DT
10_1101-2020_06_17_156679	231	19	377	377	CD
10_1101-2020_06_17_156679	231	20	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	231	21	MHV	MHV	NNP
10_1101-2020_06_17_156679	231	22	-	-	HYPH
10_1101-2020_06_17_156679	231	23	A59	A59	NNP
10_1101-2020_06_17_156679	231	24	;	;	:
10_1101-2020_06_17_156679	231	25	a	a	DT
10_1101-2020_06_17_156679	231	26	highly	highly	RB
10_1101-2020_06_17_156679	231	27	conserved	conserve	VBN
10_1101-2020_06_17_156679	231	28	polymerase	polymerase	NN
10_1101-2020_06_17_156679	231	29	is	be	VBZ
10_1101-2020_06_17_156679	231	30	expressed	express	VBN
10_1101-2020_06_17_156679	231	31	by	by	IN
10_1101-2020_06_17_156679	231	32	an	an	DT
10_1101-2020_06_17_156679	231	33	efficient	efficient	JJ
10_1101-2020_06_17_156679	231	34	ribosomal	ribosomal	JJ
10_1101-2020_06_17_156679	231	35	378	378	CD
10_1101-2020_06_17_156679	231	36	frameshifting	frameshifting	NN
10_1101-2020_06_17_156679	231	37	mechanism	mechanism	NN
10_1101-2020_06_17_156679	231	38	.	.	.
10_1101-2020_06_17_156679	232	1	Nucleic	Nucleic	NNP
10_1101-2020_06_17_156679	232	2	Acids	Acids	NNPS
10_1101-2020_06_17_156679	232	3	Res	Res	NNP
10_1101-2020_06_17_156679	232	4	.	.	.
10_1101-2020_06_17_156679	233	1	1990;18(7):1825	1990;18(7):1825	CD
10_1101-2020_06_17_156679	233	2	-	-	SYM
10_1101-2020_06_17_156679	233	3	32	32	CD
10_1101-2020_06_17_156679	233	4	.	.	.
10_1101-2020_06_17_156679	234	1	379	379	CD
10_1101-2020_06_17_156679	234	2	10	10	CD
10_1101-2020_06_17_156679	234	3	.	.	.
10_1101-2020_06_17_156679	235	1	Hilgenfeld	Hilgenfeld	NNP
10_1101-2020_06_17_156679	235	2	R.	R.	NNP
10_1101-2020_06_17_156679	235	3	From	from	IN
10_1101-2020_06_17_156679	235	4	SARS	SARS	NNP
10_1101-2020_06_17_156679	235	5	to	to	IN
10_1101-2020_06_17_156679	235	6	MERS	MERS	NNP
10_1101-2020_06_17_156679	235	7	:	:	:
10_1101-2020_06_17_156679	235	8	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	235	9	studies	study	NNS
10_1101-2020_06_17_156679	235	10	on	on	IN
10_1101-2020_06_17_156679	235	11	coronaviral	coronaviral	JJ
10_1101-2020_06_17_156679	235	12	proteases	protease	NNS
10_1101-2020_06_17_156679	235	13	enable	enable	VBP
10_1101-2020_06_17_156679	235	14	380	380	CD
10_1101-2020_06_17_156679	235	15	antiviral	antiviral	JJ
10_1101-2020_06_17_156679	235	16	drug	drug	NN
10_1101-2020_06_17_156679	235	17	design	design	NN
10_1101-2020_06_17_156679	235	18	.	.	.
10_1101-2020_06_17_156679	236	1	FEBS	FEBS	NNP
10_1101-2020_06_17_156679	236	2	J.	J.	NNP
10_1101-2020_06_17_156679	237	1	2014;281(18):4085	2014;281(18):4085	CD
10_1101-2020_06_17_156679	237	2	-	-	SYM
10_1101-2020_06_17_156679	237	3	96	96	CD
10_1101-2020_06_17_156679	237	4	.	.	.
10_1101-2020_06_17_156679	238	1	381	381	CD
10_1101-2020_06_17_156679	238	2	11	11	CD
10_1101-2020_06_17_156679	238	3	.	.	.
10_1101-2020_06_17_156679	239	1	Ghosh	Ghosh	NNP
10_1101-2020_06_17_156679	239	2	AK	AK	NNP
10_1101-2020_06_17_156679	239	3	,	,	,
10_1101-2020_06_17_156679	239	4	Xi	Xi	NNP
10_1101-2020_06_17_156679	239	5	K	K	NNP
10_1101-2020_06_17_156679	239	6	,	,	,
10_1101-2020_06_17_156679	239	7	Grum	Grum	NNP
10_1101-2020_06_17_156679	239	8	-	-	HYPH
10_1101-2020_06_17_156679	239	9	Tokars	Tokars	NNP
10_1101-2020_06_17_156679	239	10	V	V	NNP
10_1101-2020_06_17_156679	239	11	,	,	,
10_1101-2020_06_17_156679	239	12	Xu	Xu	NNP
10_1101-2020_06_17_156679	239	13	X	X	NNP
10_1101-2020_06_17_156679	239	14	,	,	,
10_1101-2020_06_17_156679	239	15	Ratia	Ratia	NNP
10_1101-2020_06_17_156679	239	16	K	K	NNP
10_1101-2020_06_17_156679	239	17	,	,	,
10_1101-2020_06_17_156679	239	18	Fu	Fu	NNP
10_1101-2020_06_17_156679	239	19	W	W	NNP
10_1101-2020_06_17_156679	239	20	,	,	,
10_1101-2020_06_17_156679	239	21	et	et	NNP
10_1101-2020_06_17_156679	239	22	al	al	NNP
10_1101-2020_06_17_156679	239	23	.	.	.
10_1101-2020_06_17_156679	240	1	Structure	structure	NN
10_1101-2020_06_17_156679	240	2	-	-	HYPH
10_1101-2020_06_17_156679	240	3	based	base	VBN
10_1101-2020_06_17_156679	240	4	design	design	NN
10_1101-2020_06_17_156679	240	5	,	,	,
10_1101-2020_06_17_156679	240	6	synthesis	synthesis	NN
10_1101-2020_06_17_156679	240	7	,	,	,
10_1101-2020_06_17_156679	240	8	382	382	CD
10_1101-2020_06_17_156679	240	9	and	and	CC
10_1101-2020_06_17_156679	240	10	biological	biological	JJ
10_1101-2020_06_17_156679	240	11	evaluation	evaluation	NN
10_1101-2020_06_17_156679	240	12	of	of	IN
10_1101-2020_06_17_156679	240	13	peptidomimetic	peptidomimetic	JJ
10_1101-2020_06_17_156679	240	14	SARS	SARS	NNP
10_1101-2020_06_17_156679	240	15	-	-	HYPH
10_1101-2020_06_17_156679	240	16	CoV	CoV	NNP
10_1101-2020_06_17_156679	240	17	3CLpro	3clpro	CD
10_1101-2020_06_17_156679	240	18	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	240	19	.	.	.
10_1101-2020_06_17_156679	241	1	Bioorg	bioorg	NN
10_1101-2020_06_17_156679	241	2	Med	Med	NNP
10_1101-2020_06_17_156679	241	3	Chem	Chem	NNP
10_1101-2020_06_17_156679	241	4	Lett	Lett	NNP
10_1101-2020_06_17_156679	241	5	.	.	.
10_1101-2020_06_17_156679	242	1	383	383	CD
10_1101-2020_06_17_156679	242	2	2007;17(21):5876	2007;17(21):5876	CD
10_1101-2020_06_17_156679	242	3	-	-	HYPH
10_1101-2020_06_17_156679	242	4	80	80	CD
10_1101-2020_06_17_156679	242	5	.	.	.
10_1101-2020_06_17_156679	243	1	384	384	CD
10_1101-2020_06_17_156679	243	2	12	12	CD
10_1101-2020_06_17_156679	243	3	.	.	.
10_1101-2020_06_17_156679	244	1	Verschueren	Verschueren	NNP
10_1101-2020_06_17_156679	244	2	KH	KH	NNP
10_1101-2020_06_17_156679	244	3	,	,	,
10_1101-2020_06_17_156679	244	4	Pumpor	Pumpor	NNP
10_1101-2020_06_17_156679	244	5	K	K	NNP
10_1101-2020_06_17_156679	244	6	,	,	,
10_1101-2020_06_17_156679	244	7	Anemuller	Anemuller	NNP
10_1101-2020_06_17_156679	244	8	S	S	NNP
10_1101-2020_06_17_156679	244	9	,	,	,
10_1101-2020_06_17_156679	244	10	Chen	Chen	NNP
10_1101-2020_06_17_156679	244	11	S	S	NNP
10_1101-2020_06_17_156679	244	12	,	,	,
10_1101-2020_06_17_156679	244	13	Mesters	Mesters	NNP
10_1101-2020_06_17_156679	244	14	JR	JR	NNP
10_1101-2020_06_17_156679	244	15	,	,	,
10_1101-2020_06_17_156679	244	16	Hilgenfeld	Hilgenfeld	NNP
10_1101-2020_06_17_156679	244	17	R.	R.	NNP
10_1101-2020_06_17_156679	244	18	A	a	DT
10_1101-2020_06_17_156679	244	19	structural	structural	JJ
10_1101-2020_06_17_156679	244	20	view	view	NN
10_1101-2020_06_17_156679	244	21	385	385	CD
10_1101-2020_06_17_156679	244	22	of	of	IN
10_1101-2020_06_17_156679	244	23	the	the	DT
10_1101-2020_06_17_156679	244	24	inactivation	inactivation	NN
10_1101-2020_06_17_156679	244	25	of	of	IN
10_1101-2020_06_17_156679	244	26	the	the	DT
10_1101-2020_06_17_156679	244	27	SARS	SARS	NNP
10_1101-2020_06_17_156679	244	28	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	244	29	main	main	JJ
10_1101-2020_06_17_156679	244	30	proteinase	proteinase	NN
10_1101-2020_06_17_156679	244	31	by	by	IN
10_1101-2020_06_17_156679	244	32	benzotriazole	benzotriazole	NN
10_1101-2020_06_17_156679	244	33	esters	ester	NNS
10_1101-2020_06_17_156679	244	34	.	.	.
10_1101-2020_06_17_156679	245	1	Chem	Chem	NNP
10_1101-2020_06_17_156679	245	2	Biol	Biol	NNP
10_1101-2020_06_17_156679	245	3	.	.	.
10_1101-2020_06_17_156679	246	1	386	386	CD
10_1101-2020_06_17_156679	246	2	2008;15(6):597	2008;15(6):597	CD
10_1101-2020_06_17_156679	246	3	-	-	SYM
10_1101-2020_06_17_156679	246	4	606	606	CD
10_1101-2020_06_17_156679	246	5	.	.	.
10_1101-2020_06_17_156679	247	1	387	387	CD
10_1101-2020_06_17_156679	247	2	13	13	CD
10_1101-2020_06_17_156679	247	3	.	.	.
10_1101-2020_06_17_156679	248	1	Yang	Yang	NNP
10_1101-2020_06_17_156679	248	2	H	H	NNP
10_1101-2020_06_17_156679	248	3	,	,	,
10_1101-2020_06_17_156679	248	4	Yang	Yang	NNP
10_1101-2020_06_17_156679	248	5	M	M	NNP
10_1101-2020_06_17_156679	248	6	,	,	,
10_1101-2020_06_17_156679	248	7	Ding	Ding	NNP
10_1101-2020_06_17_156679	248	8	Y	Y	NNP
10_1101-2020_06_17_156679	248	9	,	,	,
10_1101-2020_06_17_156679	248	10	Liu	Liu	NNP
10_1101-2020_06_17_156679	248	11	Y	Y	NNP
10_1101-2020_06_17_156679	248	12	,	,	,
10_1101-2020_06_17_156679	248	13	Lou	Lou	NNP
10_1101-2020_06_17_156679	248	14	Z	Z	NNP
10_1101-2020_06_17_156679	248	15	,	,	,
10_1101-2020_06_17_156679	248	16	Zhou	Zhou	NNP
10_1101-2020_06_17_156679	248	17	Z	Z	NNP
10_1101-2020_06_17_156679	248	18	,	,	,
10_1101-2020_06_17_156679	248	19	et	et	NNP
10_1101-2020_06_17_156679	248	20	al	al	NNP
10_1101-2020_06_17_156679	248	21	.	.	.
10_1101-2020_06_17_156679	249	1	The	the	DT
10_1101-2020_06_17_156679	249	2	crystal	crystal	NN
10_1101-2020_06_17_156679	249	3	structures	structure	NNS
10_1101-2020_06_17_156679	249	4	of	of	IN
10_1101-2020_06_17_156679	249	5	severe	severe	JJ
10_1101-2020_06_17_156679	249	6	acute	acute	JJ
10_1101-2020_06_17_156679	249	7	388	388	CD
10_1101-2020_06_17_156679	249	8	respiratory	respiratory	JJ
10_1101-2020_06_17_156679	249	9	syndrome	syndrome	NN
10_1101-2020_06_17_156679	249	10	virus	virus	NN
10_1101-2020_06_17_156679	249	11	main	main	JJ
10_1101-2020_06_17_156679	249	12	protease	protease	NN
10_1101-2020_06_17_156679	249	13	and	and	CC
10_1101-2020_06_17_156679	249	14	its	-PRON-	PRP$
10_1101-2020_06_17_156679	249	15	complex	complex	NN
10_1101-2020_06_17_156679	249	16	with	with	IN
10_1101-2020_06_17_156679	249	17	an	an	DT
10_1101-2020_06_17_156679	249	18	inhibitor	inhibitor	NN
10_1101-2020_06_17_156679	249	19	.	.	.
10_1101-2020_06_17_156679	250	1	Proc	Proc	NNP
10_1101-2020_06_17_156679	250	2	Natl	Natl	NNP
10_1101-2020_06_17_156679	250	3	Acad	Acad	NNP
10_1101-2020_06_17_156679	250	4	Sci	Sci	NNP
10_1101-2020_06_17_156679	250	5	U	U	NNP
10_1101-2020_06_17_156679	250	6	S	S	NNP
10_1101-2020_06_17_156679	250	7	A.	a.	NN
10_1101-2020_06_17_156679	251	1	389	389	CD
10_1101-2020_06_17_156679	251	2	2003;100(23):13190	2003;100(23):13190	CD
10_1101-2020_06_17_156679	251	3	-	-	SYM
10_1101-2020_06_17_156679	251	4	5	5	CD
10_1101-2020_06_17_156679	251	5	.	.	.
10_1101-2020_06_17_156679	252	1	390	390	CD
10_1101-2020_06_17_156679	252	2	14	14	CD
10_1101-2020_06_17_156679	252	3	.	.	.
10_1101-2020_06_17_156679	253	1	Yang	Yang	NNP
10_1101-2020_06_17_156679	253	2	H	H	NNP
10_1101-2020_06_17_156679	253	3	,	,	,
10_1101-2020_06_17_156679	253	4	Xie	Xie	NNP
10_1101-2020_06_17_156679	253	5	W	W	NNP
10_1101-2020_06_17_156679	253	6	,	,	,
10_1101-2020_06_17_156679	253	7	Xue	Xue	NNP
10_1101-2020_06_17_156679	253	8	X	X	NNP
10_1101-2020_06_17_156679	253	9	,	,	,
10_1101-2020_06_17_156679	253	10	Yang	Yang	NNP
10_1101-2020_06_17_156679	253	11	K	K	NNP
10_1101-2020_06_17_156679	253	12	,	,	,
10_1101-2020_06_17_156679	253	13	Ma	Ma	NNP
10_1101-2020_06_17_156679	253	14	J	J	NNP
10_1101-2020_06_17_156679	253	15	,	,	,
10_1101-2020_06_17_156679	253	16	Liang	Liang	NNP
10_1101-2020_06_17_156679	253	17	W	W	NNP
10_1101-2020_06_17_156679	253	18	,	,	,
10_1101-2020_06_17_156679	253	19	et	et	NNP
10_1101-2020_06_17_156679	253	20	al	al	NNP
10_1101-2020_06_17_156679	253	21	.	.	.
10_1101-2020_06_17_156679	254	1	Design	design	NN
10_1101-2020_06_17_156679	254	2	of	of	IN
10_1101-2020_06_17_156679	254	3	wide	wide	JJ
10_1101-2020_06_17_156679	254	4	-	-	HYPH
10_1101-2020_06_17_156679	254	5	spectrum	spectrum	NN
10_1101-2020_06_17_156679	254	6	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	254	7	391	391	CD
10_1101-2020_06_17_156679	254	8	targeting	target	VBG
10_1101-2020_06_17_156679	254	9	coronavirus	coronavirus	NN
10_1101-2020_06_17_156679	254	10	main	main	JJ
10_1101-2020_06_17_156679	254	11	proteases	protease	NNS
10_1101-2020_06_17_156679	254	12	.	.	.
10_1101-2020_06_17_156679	255	1	PLoS	PLoS	NNP
10_1101-2020_06_17_156679	255	2	Biol	Biol	NNP
10_1101-2020_06_17_156679	255	3	.	.	.
10_1101-2020_06_17_156679	256	1	2005;3(10):e324	2005;3(10):e324	CD
10_1101-2020_06_17_156679	256	2	.	.	.
10_1101-2020_06_17_156679	257	1	392	392	CD
10_1101-2020_06_17_156679	257	2	15	15	CD
10_1101-2020_06_17_156679	257	3	.	.	.
10_1101-2020_06_17_156679	258	1	Zhang	Zhang	NNP
10_1101-2020_06_17_156679	258	2	L	L	NNP
10_1101-2020_06_17_156679	258	3	,	,	,
10_1101-2020_06_17_156679	258	4	Lin	Lin	NNP
10_1101-2020_06_17_156679	258	5	D	D	NNP
10_1101-2020_06_17_156679	258	6	,	,	,
10_1101-2020_06_17_156679	258	7	Sun	Sun	NNP
10_1101-2020_06_17_156679	258	8	X	X	NNP
10_1101-2020_06_17_156679	258	9	,	,	,
10_1101-2020_06_17_156679	258	10	Curth	Curth	NNP
10_1101-2020_06_17_156679	258	11	U	U	NNP
10_1101-2020_06_17_156679	258	12	,	,	,
10_1101-2020_06_17_156679	258	13	Drosten	Drosten	NNP
10_1101-2020_06_17_156679	258	14	C	C	NNP
10_1101-2020_06_17_156679	258	15	,	,	,
10_1101-2020_06_17_156679	258	16	Sauerhering	Sauerhering	NNP
10_1101-2020_06_17_156679	258	17	L	L	NNP
10_1101-2020_06_17_156679	258	18	,	,	,
10_1101-2020_06_17_156679	258	19	et	et	NNP
10_1101-2020_06_17_156679	258	20	al	al	NNP
10_1101-2020_06_17_156679	258	21	.	.	.
10_1101-2020_06_17_156679	259	1	Crystal	crystal	JJ
10_1101-2020_06_17_156679	259	2	structure	structure	NN
10_1101-2020_06_17_156679	259	3	of	of	IN
10_1101-2020_06_17_156679	259	4	SARS	SARS	NNP
10_1101-2020_06_17_156679	259	5	-	-	HYPH
10_1101-2020_06_17_156679	259	6	CoV-393	CoV-393	NNP
10_1101-2020_06_17_156679	259	7	2	2	CD
10_1101-2020_06_17_156679	259	8	main	main	JJ
10_1101-2020_06_17_156679	259	9	protease	protease	NN
10_1101-2020_06_17_156679	259	10	provides	provide	VBZ
10_1101-2020_06_17_156679	259	11	a	a	DT
10_1101-2020_06_17_156679	259	12	basis	basis	NN
10_1101-2020_06_17_156679	259	13	for	for	IN
10_1101-2020_06_17_156679	259	14	design	design	NN
10_1101-2020_06_17_156679	259	15	of	of	IN
10_1101-2020_06_17_156679	259	16	improved	improve	VBN
10_1101-2020_06_17_156679	259	17	alpha	alpha	NN
10_1101-2020_06_17_156679	259	18	-	-	HYPH
10_1101-2020_06_17_156679	259	19	ketoamide	ketoamide	NN
10_1101-2020_06_17_156679	259	20	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	259	21	.	.	.
10_1101-2020_06_17_156679	260	1	Science	science	NN
10_1101-2020_06_17_156679	260	2	.	.	.
10_1101-2020_06_17_156679	261	1	394	394	CD
10_1101-2020_06_17_156679	261	2	2020;368(6489):409	2020;368(6489):409	CD
10_1101-2020_06_17_156679	261	3	-	-	SYM
10_1101-2020_06_17_156679	261	4	12	12	CD
10_1101-2020_06_17_156679	261	5	.	.	.
10_1101-2020_06_17_156679	262	1	395	395	CD
10_1101-2020_06_17_156679	262	2	16	16	CD
10_1101-2020_06_17_156679	262	3	.	.	.
10_1101-2020_06_17_156679	263	1	Rut	Rut	NNP
10_1101-2020_06_17_156679	263	2	W	W	NNP
10_1101-2020_06_17_156679	263	3	,	,	,
10_1101-2020_06_17_156679	263	4	Groborz	Groborz	NNP
10_1101-2020_06_17_156679	263	5	K	K	NNP
10_1101-2020_06_17_156679	263	6	,	,	,
10_1101-2020_06_17_156679	263	7	Zhang	Zhang	NNP
10_1101-2020_06_17_156679	263	8	L	L	NNP
10_1101-2020_06_17_156679	263	9	,	,	,
10_1101-2020_06_17_156679	263	10	Sun	Sun	NNP
10_1101-2020_06_17_156679	263	11	X	X	NNP
10_1101-2020_06_17_156679	263	12	,	,	,
10_1101-2020_06_17_156679	263	13	Zmudzinski	Zmudzinski	NNP
10_1101-2020_06_17_156679	263	14	M	M	NNP
10_1101-2020_06_17_156679	263	15	,	,	,
10_1101-2020_06_17_156679	263	16	Pawlik	Pawlik	NNP
10_1101-2020_06_17_156679	263	17	B	B	NNP
10_1101-2020_06_17_156679	263	18	,	,	,
10_1101-2020_06_17_156679	263	19	et	et	NNP
10_1101-2020_06_17_156679	263	20	al	al	NNP
10_1101-2020_06_17_156679	263	21	.	.	.
10_1101-2020_06_17_156679	264	1	SARS	SARS	NNP
10_1101-2020_06_17_156679	264	2	-	-	HYPH
10_1101-2020_06_17_156679	264	3	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	264	4	M(pro	M(pro	NNP
10_1101-2020_06_17_156679	264	5	)	)	-RRB-
10_1101-2020_06_17_156679	264	6	396	396	CD
10_1101-2020_06_17_156679	264	7	inhibitors	inhibitor	NNS
10_1101-2020_06_17_156679	264	8	and	and	CC
10_1101-2020_06_17_156679	264	9	activity	activity	NN
10_1101-2020_06_17_156679	264	10	-	-	HYPH
10_1101-2020_06_17_156679	264	11	based	base	VBN
10_1101-2020_06_17_156679	264	12	probes	probe	NNS
10_1101-2020_06_17_156679	264	13	for	for	IN
10_1101-2020_06_17_156679	264	14	patient	patient	JJ
10_1101-2020_06_17_156679	264	15	-	-	HYPH
10_1101-2020_06_17_156679	264	16	sample	sample	NN
10_1101-2020_06_17_156679	264	17	imaging	imaging	NN
10_1101-2020_06_17_156679	264	18	.	.	.
10_1101-2020_06_17_156679	265	1	Nat	Nat	NNP
10_1101-2020_06_17_156679	265	2	Chem	Chem	NNP
10_1101-2020_06_17_156679	265	3	Biol	Biol	NNP
10_1101-2020_06_17_156679	265	4	.	.	.
10_1101-2020_06_17_156679	266	1	2020	2020	CD
10_1101-2020_06_17_156679	266	2	.	.	.
10_1101-2020_06_17_156679	267	1	397	397	CD
10_1101-2020_06_17_156679	267	2	17	17	CD
10_1101-2020_06_17_156679	267	3	.	.	CD
10_1101-2020_06_17_156679	267	4	,	,	,
10_1101-2020_06_17_156679	267	5	Achdout	Achdout	NNP
10_1101-2020_06_17_156679	267	6	H	H	NNP
10_1101-2020_06_17_156679	267	7	,	,	,
10_1101-2020_06_17_156679	267	8	Aimon	Aimon	NNP
10_1101-2020_06_17_156679	267	9	A	A	NNP
10_1101-2020_06_17_156679	267	10	,	,	,
10_1101-2020_06_17_156679	267	11	Bar	Bar	NNP
10_1101-2020_06_17_156679	267	12	-	-	HYPH
10_1101-2020_06_17_156679	267	13	David	David	NNP
10_1101-2020_06_17_156679	267	14	E	E	NNP
10_1101-2020_06_17_156679	267	15	,	,	,
10_1101-2020_06_17_156679	267	16	Barr	Barr	NNP
10_1101-2020_06_17_156679	267	17	H	H	NNP
10_1101-2020_06_17_156679	267	18	,	,	,
10_1101-2020_06_17_156679	267	19	Ben	Ben	NNP
10_1101-2020_06_17_156679	267	20	-	-	HYPH
10_1101-2020_06_17_156679	267	21	Shmuel	Shmuel	NNP
10_1101-2020_06_17_156679	267	22	A	A	NNP
10_1101-2020_06_17_156679	267	23	,	,	,
10_1101-2020_06_17_156679	267	24	et	et	NNP
10_1101-2020_06_17_156679	267	25	al	al	NNP
10_1101-2020_06_17_156679	267	26	.	.	.
10_1101-2020_06_17_156679	268	1	COVID	COVID	NNP
10_1101-2020_06_17_156679	268	2	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	268	3	:	:	:
10_1101-2020_06_17_156679	268	4	Open	open	VB
10_1101-2020_06_17_156679	268	5	398	398	CD
10_1101-2020_06_17_156679	268	6	Science	Science	NNP
10_1101-2020_06_17_156679	268	7	Discovery	Discovery	NNP
10_1101-2020_06_17_156679	268	8	of	of	IN
10_1101-2020_06_17_156679	268	9	SARS	SARS	NNP
10_1101-2020_06_17_156679	268	10	-	-	HYPH
10_1101-2020_06_17_156679	268	11	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	268	12	Main	Main	NNP
10_1101-2020_06_17_156679	268	13	Protease	Protease	NNP
10_1101-2020_06_17_156679	268	14	Inhibitors	Inhibitors	NNPS
10_1101-2020_06_17_156679	268	15	by	by	IN
10_1101-2020_06_17_156679	268	16	Combining	combine	VBG
10_1101-2020_06_17_156679	268	17	Crowdsourcing	Crowdsourcing	NNP
10_1101-2020_06_17_156679	268	18	,	,	,
10_1101-2020_06_17_156679	268	19	High-399	High-399	NFP
10_1101-2020_06_17_156679	268	20	Throughput	throughput	NN
10_1101-2020_06_17_156679	268	21	Experiments	Experiments	NNPS
10_1101-2020_06_17_156679	268	22	,	,	,
10_1101-2020_06_17_156679	268	23	Computational	Computational	NNP
10_1101-2020_06_17_156679	268	24	Simulations	Simulations	NNPS
10_1101-2020_06_17_156679	268	25	,	,	,
10_1101-2020_06_17_156679	268	26	and	and	CC
10_1101-2020_06_17_156679	268	27	Machine	Machine	NNP
10_1101-2020_06_17_156679	268	28	Learning	Learning	NNP
10_1101-2020_06_17_156679	268	29	.	.	.
10_1101-2020_06_17_156679	269	1	bioRxiv	biorxiv	NN
10_1101-2020_06_17_156679	269	2	.	.	.
10_1101-2020_06_17_156679	270	1	2020	2020	CD
10_1101-2020_06_17_156679	270	2	.	.	.
10_1101-2020_06_17_156679	271	1	400	400	CD
10_1101-2020_06_17_156679	271	2	18	18	CD
10_1101-2020_06_17_156679	271	3	.	.	.
10_1101-2020_06_17_156679	272	1	Douangamath	Douangamath	NNP
10_1101-2020_06_17_156679	272	2	A	A	NNP
10_1101-2020_06_17_156679	272	3	,	,	,
10_1101-2020_06_17_156679	272	4	Fearon	Fearon	NNP
10_1101-2020_06_17_156679	272	5	D	D	NNP
10_1101-2020_06_17_156679	272	6	,	,	,
10_1101-2020_06_17_156679	272	7	Gehrtz	Gehrtz	NNP
10_1101-2020_06_17_156679	272	8	P	P	NNP
10_1101-2020_06_17_156679	272	9	,	,	,
10_1101-2020_06_17_156679	272	10	Krojer	Krojer	NNP
10_1101-2020_06_17_156679	272	11	T	T	NNP
10_1101-2020_06_17_156679	272	12	,	,	,
10_1101-2020_06_17_156679	272	13	Lukacik	Lukacik	NNP
10_1101-2020_06_17_156679	272	14	P	P	NNP
10_1101-2020_06_17_156679	272	15	,	,	,
10_1101-2020_06_17_156679	272	16	Owen	Owen	NNP
10_1101-2020_06_17_156679	272	17	CD	CD	NNP
10_1101-2020_06_17_156679	272	18	,	,	,
10_1101-2020_06_17_156679	272	19	et	et	NNP
10_1101-2020_06_17_156679	272	20	al	al	NNP
10_1101-2020_06_17_156679	272	21	.	.	.
10_1101-2020_06_17_156679	273	1	Crystallographic	Crystallographic	NNP
10_1101-2020_06_17_156679	273	2	401	401	CD
10_1101-2020_06_17_156679	273	3	and	and	CC
10_1101-2020_06_17_156679	273	4	electrophilic	electrophilic	JJ
10_1101-2020_06_17_156679	273	5	fragment	fragment	NN
10_1101-2020_06_17_156679	273	6	screening	screening	NN
10_1101-2020_06_17_156679	273	7	of	of	IN
10_1101-2020_06_17_156679	273	8	the	the	DT
10_1101-2020_06_17_156679	273	9	SARS	SARS	NNP
10_1101-2020_06_17_156679	273	10	-	-	HYPH
10_1101-2020_06_17_156679	273	11	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	273	12	main	main	JJ
10_1101-2020_06_17_156679	273	13	protease	protease	NN
10_1101-2020_06_17_156679	273	14	.	.	.
10_1101-2020_06_17_156679	274	1	Nat	Nat	NNP
10_1101-2020_06_17_156679	274	2	Commun	Commun	NNP
10_1101-2020_06_17_156679	274	3	.	.	.
10_1101-2020_06_17_156679	275	1	402	402	CD
10_1101-2020_06_17_156679	275	2	2020;11(1):5047	2020;11(1):5047	CD
10_1101-2020_06_17_156679	275	3	.	.	.
10_1101-2020_06_17_156679	276	1	403	403	CD
10_1101-2020_06_17_156679	276	2	.CC	.CC	:
10_1101-2020_06_17_156679	276	3	-	-	:
10_1101-2020_06_17_156679	276	4	BY	by	IN
10_1101-2020_06_17_156679	276	5	4.0	4.0	CD
10_1101-2020_06_17_156679	276	6	International	International	NNP
10_1101-2020_06_17_156679	276	7	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	276	8	under	under	IN
10_1101-2020_06_17_156679	276	9	a	a	DT
10_1101-2020_06_17_156679	276	10	(	(	-LRB-
10_1101-2020_06_17_156679	276	11	which	which	WDT
10_1101-2020_06_17_156679	276	12	was	be	VBD
10_1101-2020_06_17_156679	276	13	not	not	RB
10_1101-2020_06_17_156679	276	14	certified	certify	VBN
10_1101-2020_06_17_156679	276	15	by	by	IN
10_1101-2020_06_17_156679	276	16	peer	peer	NN
10_1101-2020_06_17_156679	276	17	review	review	NN
10_1101-2020_06_17_156679	276	18	)	)	-RRB-
10_1101-2020_06_17_156679	276	19	is	be	VBZ
10_1101-2020_06_17_156679	276	20	the	the	DT
10_1101-2020_06_17_156679	276	21	author	author	NN
10_1101-2020_06_17_156679	276	22	/	/	SYM
10_1101-2020_06_17_156679	276	23	funder	funder	NN
10_1101-2020_06_17_156679	276	24	,	,	,
10_1101-2020_06_17_156679	276	25	who	who	WP
10_1101-2020_06_17_156679	276	26	has	have	VBZ
10_1101-2020_06_17_156679	276	27	granted	grant	VBN
10_1101-2020_06_17_156679	276	28	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	276	29	a	a	DT
10_1101-2020_06_17_156679	276	30	license	license	NN
10_1101-2020_06_17_156679	276	31	to	to	TO
10_1101-2020_06_17_156679	276	32	display	display	VB
10_1101-2020_06_17_156679	276	33	the	the	DT
10_1101-2020_06_17_156679	276	34	preprint	preprint	NN
10_1101-2020_06_17_156679	276	35	in	in	IN
10_1101-2020_06_17_156679	276	36	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	276	37	.	.	.
10_1101-2020_06_17_156679	277	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	277	2	is	be	VBZ
10_1101-2020_06_17_156679	277	3	made	make	VBN
10_1101-2020_06_17_156679	277	4	The	the	DT
10_1101-2020_06_17_156679	277	5	copyright	copyright	NN
10_1101-2020_06_17_156679	277	6	holder	holder	NN
10_1101-2020_06_17_156679	277	7	for	for	IN
10_1101-2020_06_17_156679	277	8	this	this	DT
10_1101-2020_06_17_156679	277	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	277	10	version	version	NN
10_1101-2020_06_17_156679	277	11	posted	post	VBD
10_1101-2020_06_17_156679	277	12	January	January	NNP
10_1101-2020_06_17_156679	277	13	6	6	CD
10_1101-2020_06_17_156679	277	14	,	,	,
10_1101-2020_06_17_156679	277	15	2021	2021	CD
10_1101-2020_06_17_156679	277	16	.	.	.
10_1101-2020_06_17_156679	277	17	;	;	:
10_1101-2020_06_17_156679	277	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	277	19	:	:	:
10_1101-2020_06_17_156679	277	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	277	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	277	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	NN
10_1101-2020_06_17_156679	277	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	277	24	15	15	CD
10_1101-2020_06_17_156679	277	25	19	19	CD
10_1101-2020_06_17_156679	277	26	.	.	.
10_1101-2020_06_17_156679	278	1	El	El	NNP
10_1101-2020_06_17_156679	278	2	-	-	HYPH
10_1101-2020_06_17_156679	278	3	Baba	Baba	NNP
10_1101-2020_06_17_156679	278	4	TJ	TJ	NNP
10_1101-2020_06_17_156679	278	5	,	,	,
10_1101-2020_06_17_156679	278	6	Lutomski	Lutomski	NNP
10_1101-2020_06_17_156679	278	7	CA	CA	NNP
10_1101-2020_06_17_156679	278	8	,	,	,
10_1101-2020_06_17_156679	278	9	Kantsadi	Kantsadi	NNP
10_1101-2020_06_17_156679	278	10	AL	AL	NNP
10_1101-2020_06_17_156679	278	11	,	,	,
10_1101-2020_06_17_156679	278	12	Malla	Malla	NNP
10_1101-2020_06_17_156679	278	13	TR	TR	NNP
10_1101-2020_06_17_156679	278	14	,	,	,
10_1101-2020_06_17_156679	278	15	John	John	NNP
10_1101-2020_06_17_156679	278	16	T	T	NNP
10_1101-2020_06_17_156679	278	17	,	,	,
10_1101-2020_06_17_156679	278	18	Mikhailov	Mikhailov	NNP
10_1101-2020_06_17_156679	278	19	V	V	NNP
10_1101-2020_06_17_156679	278	20	,	,	,
10_1101-2020_06_17_156679	278	21	et	et	NNP
10_1101-2020_06_17_156679	278	22	al	al	NNP
10_1101-2020_06_17_156679	278	23	.	.	.
10_1101-2020_06_17_156679	279	1	Allosteric	Allosteric	NNP
10_1101-2020_06_17_156679	279	2	Inhibition	inhibition	NN
10_1101-2020_06_17_156679	279	3	404	404	CD
10_1101-2020_06_17_156679	279	4	of	of	IN
10_1101-2020_06_17_156679	279	5	the	the	DT
10_1101-2020_06_17_156679	279	6	SARS	SARS	NNP
10_1101-2020_06_17_156679	279	7	-	-	HYPH
10_1101-2020_06_17_156679	279	8	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	279	9	Main	Main	NNP
10_1101-2020_06_17_156679	279	10	Protease	protease	NN
10_1101-2020_06_17_156679	279	11	:	:	:
10_1101-2020_06_17_156679	279	12	Insights	insight	NNS
10_1101-2020_06_17_156679	279	13	from	from	IN
10_1101-2020_06_17_156679	279	14	Mass	Mass	NNP
10_1101-2020_06_17_156679	279	15	Spectrometry	Spectrometry	NNP
10_1101-2020_06_17_156679	279	16	Based	Based	NNP
10_1101-2020_06_17_156679	279	17	Assays	Assays	NNPS
10_1101-2020_06_17_156679	279	18	.	.	.
10_1101-2020_06_17_156679	280	1	Angew	angew	VB
10_1101-2020_06_17_156679	280	2	Chem	Chem	NNP
10_1101-2020_06_17_156679	280	3	Int	Int	NNP
10_1101-2020_06_17_156679	280	4	405	405	CD
10_1101-2020_06_17_156679	280	5	Edit	Edit	NNP
10_1101-2020_06_17_156679	280	6	.	.	.
10_1101-2020_06_17_156679	281	1	2020	2020	CD
10_1101-2020_06_17_156679	281	2	.	.	.
10_1101-2020_06_17_156679	282	1	406	406	CD
10_1101-2020_06_17_156679	282	2	20	20	CD
10_1101-2020_06_17_156679	282	3	.	.	.
10_1101-2020_06_17_156679	283	1	Mayer	Mayer	NNP
10_1101-2020_06_17_156679	283	2	M	M	NNP
10_1101-2020_06_17_156679	283	3	,	,	,
10_1101-2020_06_17_156679	283	4	Meyer	Meyer	NNP
10_1101-2020_06_17_156679	283	5	B.	B.	NNP
10_1101-2020_06_17_156679	284	1	Characterization	Characterization	NNP
10_1101-2020_06_17_156679	284	2	of	of	IN
10_1101-2020_06_17_156679	284	3	Ligand	Ligand	NNP
10_1101-2020_06_17_156679	284	4	Binding	Binding	NNP
10_1101-2020_06_17_156679	284	5	by	by	IN
10_1101-2020_06_17_156679	284	6	Saturation	Saturation	NNP
10_1101-2020_06_17_156679	284	7	Transfer	Transfer	NNP
10_1101-2020_06_17_156679	284	8	Difference	Difference	NNP
10_1101-2020_06_17_156679	284	9	407	407	CD
10_1101-2020_06_17_156679	284	10	NMR	NMR	NNP
10_1101-2020_06_17_156679	284	11	Spectroscopy	Spectroscopy	NNP
10_1101-2020_06_17_156679	284	12	.	.	.
10_1101-2020_06_17_156679	285	1	Angew	angew	VB
10_1101-2020_06_17_156679	285	2	Chem	Chem	NNP
10_1101-2020_06_17_156679	285	3	Int	Int	NNP
10_1101-2020_06_17_156679	285	4	Ed	Ed	NNP
10_1101-2020_06_17_156679	285	5	Engl	Engl	NNP
10_1101-2020_06_17_156679	285	6	.	.	.
10_1101-2020_06_17_156679	286	1	1999;38(12):1784	1999;38(12):1784	NNP
10_1101-2020_06_17_156679	286	2	-	-	SYM
10_1101-2020_06_17_156679	286	3	8	8	CD
10_1101-2020_06_17_156679	286	4	.	.	.
10_1101-2020_06_17_156679	287	1	408	408	CD
10_1101-2020_06_17_156679	287	2	21	21	CD
10_1101-2020_06_17_156679	287	3	.	.	.
10_1101-2020_06_17_156679	288	1	Becker	Becker	NNP
10_1101-2020_06_17_156679	288	2	W	W	NNP
10_1101-2020_06_17_156679	288	3	,	,	,
10_1101-2020_06_17_156679	288	4	Bhattiprolu	Bhattiprolu	NNP
10_1101-2020_06_17_156679	288	5	KC	KC	NNP
10_1101-2020_06_17_156679	288	6	,	,	,
10_1101-2020_06_17_156679	288	7	Gubensak	Gubensak	NNP
10_1101-2020_06_17_156679	288	8	N	N	NNP
10_1101-2020_06_17_156679	288	9	,	,	,
10_1101-2020_06_17_156679	288	10	Zangger	Zangger	NNP
10_1101-2020_06_17_156679	288	11	K.	K.	NNP
10_1101-2020_06_17_156679	288	12	Investigating	Investigating	NNP
10_1101-2020_06_17_156679	288	13	Protein	Protein	NNP
10_1101-2020_06_17_156679	288	14	-	-	HYPH
10_1101-2020_06_17_156679	288	15	Ligand	Ligand	NNP
10_1101-2020_06_17_156679	288	16	Interactions	Interactions	NNPS
10_1101-2020_06_17_156679	288	17	409	409	CD
10_1101-2020_06_17_156679	288	18	by	by	IN
10_1101-2020_06_17_156679	288	19	Solution	Solution	NNP
10_1101-2020_06_17_156679	288	20	Nuclear	Nuclear	NNP
10_1101-2020_06_17_156679	288	21	Magnetic	Magnetic	NNP
10_1101-2020_06_17_156679	288	22	Resonance	Resonance	NNP
10_1101-2020_06_17_156679	288	23	Spectroscopy	Spectroscopy	NNP
10_1101-2020_06_17_156679	288	24	.	.	.
10_1101-2020_06_17_156679	289	1	Chemphyschem	Chemphyschem	NNP
10_1101-2020_06_17_156679	289	2	.	.	.
10_1101-2020_06_17_156679	290	1	2018;19(8):895	2018;19(8):895	CD
10_1101-2020_06_17_156679	290	2	-	-	SYM
10_1101-2020_06_17_156679	290	3	906	906	CD
10_1101-2020_06_17_156679	290	4	.	.	.
10_1101-2020_06_17_156679	291	1	410	410	CD
10_1101-2020_06_17_156679	291	2	22	22	CD
10_1101-2020_06_17_156679	291	3	.	.	.
10_1101-2020_06_17_156679	292	1	Walpole	Walpole	NNP
10_1101-2020_06_17_156679	292	2	S	S	NNP
10_1101-2020_06_17_156679	292	3	,	,	,
10_1101-2020_06_17_156679	292	4	Monaco	Monaco	NNP
10_1101-2020_06_17_156679	292	5	S	S	NNP
10_1101-2020_06_17_156679	292	6	,	,	,
10_1101-2020_06_17_156679	292	7	Nepravishta	Nepravishta	NNP
10_1101-2020_06_17_156679	292	8	R	R	NNP
10_1101-2020_06_17_156679	292	9	,	,	,
10_1101-2020_06_17_156679	292	10	Angulo	Angulo	NNP
10_1101-2020_06_17_156679	292	11	J.	J.	NNP
10_1101-2020_06_17_156679	292	12	STD	STD	NNP
10_1101-2020_06_17_156679	292	13	NMR	NMR	NNP
10_1101-2020_06_17_156679	292	14	as	as	IN
10_1101-2020_06_17_156679	292	15	a	a	DT
10_1101-2020_06_17_156679	292	16	technique	technique	NN
10_1101-2020_06_17_156679	292	17	for	for	IN
10_1101-2020_06_17_156679	292	18	ligand	ligand	NN
10_1101-2020_06_17_156679	292	19	screening	screen	VBG
10_1101-2020_06_17_156679	292	20	411	411	CD
10_1101-2020_06_17_156679	292	21	and	and	CC
10_1101-2020_06_17_156679	292	22	structural	structural	JJ
10_1101-2020_06_17_156679	292	23	studies	study	NNS
10_1101-2020_06_17_156679	292	24	.	.	.
10_1101-2020_06_17_156679	293	1	Methods	method	NNS
10_1101-2020_06_17_156679	293	2	in	in	IN
10_1101-2020_06_17_156679	293	3	Enzymology	Enzymology	NNP
10_1101-2020_06_17_156679	293	4	.	.	.
10_1101-2020_06_17_156679	294	1	615	615	CD
10_1101-2020_06_17_156679	294	2	:	:	:
10_1101-2020_06_17_156679	294	3	Elsevier	elsevier	NN
10_1101-2020_06_17_156679	294	4	;	;	:
10_1101-2020_06_17_156679	294	5	2019	2019	CD
10_1101-2020_06_17_156679	294	6	.	.	.
10_1101-2020_06_17_156679	294	7	p.	p.	NN
10_1101-2020_06_17_156679	294	8	423	423	CD
10_1101-2020_06_17_156679	294	9	-	-	SYM
10_1101-2020_06_17_156679	294	10	51	51	CD
10_1101-2020_06_17_156679	294	11	.	.	.
10_1101-2020_06_17_156679	295	1	412	412	CD
10_1101-2020_06_17_156679	295	2	23	23	CD
10_1101-2020_06_17_156679	295	3	.	.	.
10_1101-2020_06_17_156679	296	1	Rogala	Rogala	NNP
10_1101-2020_06_17_156679	296	2	KB	KB	NNP
10_1101-2020_06_17_156679	296	3	,	,	,
10_1101-2020_06_17_156679	296	4	Dynes	Dynes	NNP
10_1101-2020_06_17_156679	296	5	NJ	NJ	NNP
10_1101-2020_06_17_156679	296	6	,	,	,
10_1101-2020_06_17_156679	296	7	Hatzopoulos	Hatzopoulos	NNP
10_1101-2020_06_17_156679	296	8	GN	GN	NNP
10_1101-2020_06_17_156679	296	9	,	,	,
10_1101-2020_06_17_156679	296	10	Yan	Yan	NNP
10_1101-2020_06_17_156679	296	11	J	J	NNP
10_1101-2020_06_17_156679	296	12	,	,	,
10_1101-2020_06_17_156679	296	13	Pong	Pong	NNP
10_1101-2020_06_17_156679	296	14	SK	SK	NNP
10_1101-2020_06_17_156679	296	15	,	,	,
10_1101-2020_06_17_156679	296	16	Robinson	Robinson	NNP
10_1101-2020_06_17_156679	296	17	CV	CV	NNP
10_1101-2020_06_17_156679	296	18	,	,	,
10_1101-2020_06_17_156679	296	19	et	et	NNP
10_1101-2020_06_17_156679	296	20	al	al	NNP
10_1101-2020_06_17_156679	296	21	.	.	.
10_1101-2020_06_17_156679	297	1	The	the	DT
10_1101-2020_06_17_156679	297	2	Caenorhabditis	Caenorhabditis	NNP
10_1101-2020_06_17_156679	297	3	413	413	CD
10_1101-2020_06_17_156679	297	4	elegans	elegan	NNS
10_1101-2020_06_17_156679	297	5	protein	protein	NN
10_1101-2020_06_17_156679	297	6	SAS-5	sas-5	JJ
10_1101-2020_06_17_156679	297	7	forms	form	NNS
10_1101-2020_06_17_156679	297	8	large	large	JJ
10_1101-2020_06_17_156679	297	9	oligomeric	oligomeric	JJ
10_1101-2020_06_17_156679	297	10	assemblies	assembly	NNS
10_1101-2020_06_17_156679	297	11	critical	critical	JJ
10_1101-2020_06_17_156679	297	12	for	for	IN
10_1101-2020_06_17_156679	297	13	centriole	centriole	NNP
10_1101-2020_06_17_156679	297	14	formation	formation	NN
10_1101-2020_06_17_156679	297	15	.	.	.
10_1101-2020_06_17_156679	298	1	Elife	elife	NN
10_1101-2020_06_17_156679	298	2	.	.	.
10_1101-2020_06_17_156679	299	1	414	414	CD
10_1101-2020_06_17_156679	299	2	2015;4	2015;4	CD
10_1101-2020_06_17_156679	299	3	:	:	:
10_1101-2020_06_17_156679	299	4	e07410	e07410	XX
10_1101-2020_06_17_156679	299	5	.	.	.
10_1101-2020_06_17_156679	300	1	415	415	CD
10_1101-2020_06_17_156679	300	2	24	24	CD
10_1101-2020_06_17_156679	300	3	.	.	.
10_1101-2020_06_17_156679	301	1	Hwang	Hwang	NNP
10_1101-2020_06_17_156679	301	2	TL	TL	NNP
10_1101-2020_06_17_156679	301	3	,	,	,
10_1101-2020_06_17_156679	301	4	Shaka	Shaka	NNP
10_1101-2020_06_17_156679	301	5	AJ	AJ	NNP
10_1101-2020_06_17_156679	301	6	.	.	.
10_1101-2020_06_17_156679	302	1	Water	water	NN
10_1101-2020_06_17_156679	302	2	Suppression	Suppression	NNP
10_1101-2020_06_17_156679	302	3	That	that	IN
10_1101-2020_06_17_156679	302	4	Works	Works	NNP
10_1101-2020_06_17_156679	302	5	-	-	HYPH
10_1101-2020_06_17_156679	302	6	Excitation	excitation	NN
10_1101-2020_06_17_156679	302	7	Sculpting	sculpt	VBG
10_1101-2020_06_17_156679	302	8	Using	use	VBG
10_1101-2020_06_17_156679	302	9	Arbitrary	Arbitrary	NNP
10_1101-2020_06_17_156679	302	10	416	416	CD
10_1101-2020_06_17_156679	302	11	Wave	Wave	NNP
10_1101-2020_06_17_156679	302	12	-	-	HYPH
10_1101-2020_06_17_156679	302	13	Forms	Forms	NNPS
10_1101-2020_06_17_156679	302	14	and	and	CC
10_1101-2020_06_17_156679	302	15	Pulsed	Pulsed	NNP
10_1101-2020_06_17_156679	302	16	-	-	HYPH
10_1101-2020_06_17_156679	302	17	Field	Field	NNP
10_1101-2020_06_17_156679	302	18	Gradients	Gradients	NNPS
10_1101-2020_06_17_156679	302	19	.	.	.
10_1101-2020_06_17_156679	303	1	Journal	Journal	NNP
10_1101-2020_06_17_156679	303	2	of	of	IN
10_1101-2020_06_17_156679	303	3	Magnetic	Magnetic	NNP
10_1101-2020_06_17_156679	303	4	Resonance	Resonance	NNP
10_1101-2020_06_17_156679	303	5	Series	Series	NNP
10_1101-2020_06_17_156679	303	6	A.	a.	NN
10_1101-2020_06_17_156679	304	1	1995;112(2):275	1995;112(2):275	NNP
10_1101-2020_06_17_156679	304	2	-	-	:
10_1101-2020_06_17_156679	304	3	417	417	CD
10_1101-2020_06_17_156679	304	4	9	9	CD
10_1101-2020_06_17_156679	304	5	.	.	.
10_1101-2020_06_17_156679	305	1	418	418	CD
10_1101-2020_06_17_156679	305	2	25	25	CD
10_1101-2020_06_17_156679	305	3	.	.	.
10_1101-2020_06_17_156679	306	1	Abraham	Abraham	NNP
10_1101-2020_06_17_156679	306	2	MJ	MJ	NNP
10_1101-2020_06_17_156679	306	3	,	,	,
10_1101-2020_06_17_156679	306	4	Murtola	Murtola	NNP
10_1101-2020_06_17_156679	306	5	T	T	NNP
10_1101-2020_06_17_156679	306	6	,	,	,
10_1101-2020_06_17_156679	306	7	Schulz	Schulz	NNP
10_1101-2020_06_17_156679	306	8	R	R	NNP
10_1101-2020_06_17_156679	306	9	,	,	,
10_1101-2020_06_17_156679	306	10	Páll	Páll	NNP
10_1101-2020_06_17_156679	306	11	S	S	NNP
10_1101-2020_06_17_156679	306	12	,	,	,
10_1101-2020_06_17_156679	306	13	Smith	Smith	NNP
10_1101-2020_06_17_156679	306	14	JC	JC	NNP
10_1101-2020_06_17_156679	306	15	,	,	,
10_1101-2020_06_17_156679	306	16	Hess	Hess	NNP
10_1101-2020_06_17_156679	306	17	B	B	NNP
10_1101-2020_06_17_156679	306	18	,	,	,
10_1101-2020_06_17_156679	306	19	et	et	NNP
10_1101-2020_06_17_156679	306	20	al	al	NNP
10_1101-2020_06_17_156679	306	21	.	.	.
10_1101-2020_06_17_156679	307	1	GROMACS	GROMACS	NNP
10_1101-2020_06_17_156679	307	2	:	:	:
10_1101-2020_06_17_156679	307	3	High	high	JJ
10_1101-2020_06_17_156679	307	4	419	419	CD
10_1101-2020_06_17_156679	307	5	performance	performance	NN
10_1101-2020_06_17_156679	307	6	molecular	molecular	JJ
10_1101-2020_06_17_156679	307	7	simulations	simulation	NNS
10_1101-2020_06_17_156679	307	8	through	through	IN
10_1101-2020_06_17_156679	307	9	multi	multi	JJ
10_1101-2020_06_17_156679	307	10	-	-	JJ
10_1101-2020_06_17_156679	307	11	level	level	JJ
10_1101-2020_06_17_156679	307	12	parallelism	parallelism	NN
10_1101-2020_06_17_156679	307	13	from	from	IN
10_1101-2020_06_17_156679	307	14	laptops	laptop	NNS
10_1101-2020_06_17_156679	307	15	to	to	IN
10_1101-2020_06_17_156679	307	16	supercomputers	supercomputer	NNS
10_1101-2020_06_17_156679	307	17	.	.	.
10_1101-2020_06_17_156679	308	1	420	420	CD
10_1101-2020_06_17_156679	308	2	SoftwareX.	SoftwareX.	NNP
10_1101-2020_06_17_156679	309	1	2015;1:19	2015;1:19	CD
10_1101-2020_06_17_156679	309	2	-	-	SYM
10_1101-2020_06_17_156679	309	3	25	25	CD
10_1101-2020_06_17_156679	309	4	.	.	.
10_1101-2020_06_17_156679	310	1	421	421	CD
10_1101-2020_06_17_156679	310	2	26	26	CD
10_1101-2020_06_17_156679	310	3	.	.	.
10_1101-2020_06_17_156679	311	1	Lindorff	Lindorff	NNP
10_1101-2020_06_17_156679	311	2	-	-	HYPH
10_1101-2020_06_17_156679	311	3	Larsen	Larsen	NNP
10_1101-2020_06_17_156679	311	4	K	K	NNP
10_1101-2020_06_17_156679	311	5	,	,	,
10_1101-2020_06_17_156679	311	6	Piana	Piana	NNP
10_1101-2020_06_17_156679	311	7	S	S	NNP
10_1101-2020_06_17_156679	311	8	,	,	,
10_1101-2020_06_17_156679	311	9	Palmo	Palmo	NNP
10_1101-2020_06_17_156679	311	10	K	K	NNP
10_1101-2020_06_17_156679	311	11	,	,	,
10_1101-2020_06_17_156679	311	12	Maragakis	Maragakis	NNP
10_1101-2020_06_17_156679	311	13	P	P	NNP
10_1101-2020_06_17_156679	311	14	,	,	,
10_1101-2020_06_17_156679	311	15	Klepeis	Klepeis	NNP
10_1101-2020_06_17_156679	311	16	JL	JL	NNP
10_1101-2020_06_17_156679	311	17	,	,	,
10_1101-2020_06_17_156679	311	18	Dror	Dror	NNP
10_1101-2020_06_17_156679	311	19	RO	RO	NNP
10_1101-2020_06_17_156679	311	20	,	,	,
10_1101-2020_06_17_156679	311	21	et	et	NNP
10_1101-2020_06_17_156679	311	22	al	al	NNP
10_1101-2020_06_17_156679	311	23	.	.	.
10_1101-2020_06_17_156679	312	1	Improved	improve	VBN
10_1101-2020_06_17_156679	312	2	side-422	side-422	NN
10_1101-2020_06_17_156679	312	3	chain	chain	NN
10_1101-2020_06_17_156679	312	4	torsion	torsion	NN
10_1101-2020_06_17_156679	312	5	potentials	potential	NNS
10_1101-2020_06_17_156679	312	6	for	for	IN
10_1101-2020_06_17_156679	312	7	the	the	DT
10_1101-2020_06_17_156679	312	8	Amber	Amber	NNP
10_1101-2020_06_17_156679	312	9	ff99SB	ff99SB	NNP
10_1101-2020_06_17_156679	312	10	protein	protein	NN
10_1101-2020_06_17_156679	312	11	force	force	NN
10_1101-2020_06_17_156679	312	12	field	field	NN
10_1101-2020_06_17_156679	312	13	.	.	.
10_1101-2020_06_17_156679	313	1	Proteins	protein	NNS
10_1101-2020_06_17_156679	313	2	.	.	.
10_1101-2020_06_17_156679	314	1	2010;78(8):1950	2010;78(8):1950	CD
10_1101-2020_06_17_156679	314	2	-	-	SYM
10_1101-2020_06_17_156679	314	3	8	8	CD
10_1101-2020_06_17_156679	314	4	.	.	.
10_1101-2020_06_17_156679	315	1	423	423	CD
10_1101-2020_06_17_156679	315	2	27	27	CD
10_1101-2020_06_17_156679	315	3	.	.	.
10_1101-2020_06_17_156679	316	1	Bayly	Bayly	NNP
10_1101-2020_06_17_156679	316	2	CI	CI	NNP
10_1101-2020_06_17_156679	316	3	,	,	,
10_1101-2020_06_17_156679	316	4	Cieplak	Cieplak	NNP
10_1101-2020_06_17_156679	316	5	P	P	NNP
10_1101-2020_06_17_156679	316	6	,	,	,
10_1101-2020_06_17_156679	316	7	Cornell	Cornell	NNP
10_1101-2020_06_17_156679	316	8	W	W	NNP
10_1101-2020_06_17_156679	316	9	,	,	,
10_1101-2020_06_17_156679	316	10	Kollman	Kollman	NNP
10_1101-2020_06_17_156679	316	11	PA	PA	NNP
10_1101-2020_06_17_156679	316	12	.	.	.
10_1101-2020_06_17_156679	316	13	A	a	DT
10_1101-2020_06_17_156679	316	14	well	well	RB
10_1101-2020_06_17_156679	316	15	-	-	HYPH
10_1101-2020_06_17_156679	316	16	behaved	behave	VBN
10_1101-2020_06_17_156679	316	17	electrostatic	electrostatic	JJ
10_1101-2020_06_17_156679	316	18	potential	potential	NN
10_1101-2020_06_17_156679	316	19	based	base	VBN
10_1101-2020_06_17_156679	316	20	424	424	CD
10_1101-2020_06_17_156679	316	21	method	method	NN
10_1101-2020_06_17_156679	316	22	using	use	VBG
10_1101-2020_06_17_156679	316	23	charge	charge	NN
10_1101-2020_06_17_156679	316	24	restraints	restraint	NNS
10_1101-2020_06_17_156679	316	25	for	for	IN
10_1101-2020_06_17_156679	316	26	deriving	derive	VBG
10_1101-2020_06_17_156679	316	27	atomic	atomic	JJ
10_1101-2020_06_17_156679	316	28	charges	charge	NNS
10_1101-2020_06_17_156679	316	29	:	:	:
10_1101-2020_06_17_156679	316	30	the	the	DT
10_1101-2020_06_17_156679	316	31	RESP	RESP	NNP
10_1101-2020_06_17_156679	316	32	model	model	NN
10_1101-2020_06_17_156679	316	33	.	.	.
10_1101-2020_06_17_156679	317	1	J	J	NNP
10_1101-2020_06_17_156679	317	2	Phys	Phys	NNP
10_1101-2020_06_17_156679	317	3	Chem	Chem	NNP
10_1101-2020_06_17_156679	317	4	.	.	.
10_1101-2020_06_17_156679	318	1	425	425	CD
10_1101-2020_06_17_156679	318	2	1993;97(40):10269	1993;97(40):10269	CD
10_1101-2020_06_17_156679	318	3	-	-	HYPH
10_1101-2020_06_17_156679	318	4	80	80	CD
10_1101-2020_06_17_156679	318	5	.	.	.
10_1101-2020_06_17_156679	319	1	426	426	CD
10_1101-2020_06_17_156679	319	2	28	28	CD
10_1101-2020_06_17_156679	319	3	.	.	.
10_1101-2020_06_17_156679	320	1	Bussi	Bussi	NNP
10_1101-2020_06_17_156679	320	2	G	G	NNP
10_1101-2020_06_17_156679	320	3	,	,	,
10_1101-2020_06_17_156679	320	4	Zykova	Zykova	NNP
10_1101-2020_06_17_156679	320	5	-	-	HYPH
10_1101-2020_06_17_156679	320	6	Timan	Timan	NNP
10_1101-2020_06_17_156679	320	7	T	T	NNP
10_1101-2020_06_17_156679	320	8	,	,	,
10_1101-2020_06_17_156679	320	9	Parrinello	Parrinello	NNP
10_1101-2020_06_17_156679	320	10	M.	M.	NNP
10_1101-2020_06_17_156679	320	11	Isothermal	Isothermal	NNP
10_1101-2020_06_17_156679	320	12	-	-	HYPH
10_1101-2020_06_17_156679	320	13	isobaric	isobaric	JJ
10_1101-2020_06_17_156679	320	14	molecular	molecular	JJ
10_1101-2020_06_17_156679	320	15	dynamics	dynamic	NNS
10_1101-2020_06_17_156679	320	16	using	use	VBG
10_1101-2020_06_17_156679	320	17	427	427	CD
10_1101-2020_06_17_156679	320	18	stochastic	stochastic	JJ
10_1101-2020_06_17_156679	320	19	velocity	velocity	NN
10_1101-2020_06_17_156679	320	20	rescaling	rescaling	NN
10_1101-2020_06_17_156679	320	21	.	.	.
10_1101-2020_06_17_156679	321	1	J	J	NNP
10_1101-2020_06_17_156679	321	2	Chem	Chem	NNP
10_1101-2020_06_17_156679	321	3	Phys	Phys	NNP
10_1101-2020_06_17_156679	321	4	.	.	.
10_1101-2020_06_17_156679	322	1	2009;130(7):074101	2009;130(7):074101	LS
10_1101-2020_06_17_156679	322	2	.	.	.
10_1101-2020_06_17_156679	323	1	428	428	CD
10_1101-2020_06_17_156679	323	2	29	29	CD
10_1101-2020_06_17_156679	323	3	.	.	.
10_1101-2020_06_17_156679	324	1	Darden	Darden	NNP
10_1101-2020_06_17_156679	324	2	T	T	NNP
10_1101-2020_06_17_156679	324	3	,	,	,
10_1101-2020_06_17_156679	324	4	York	York	NNP
10_1101-2020_06_17_156679	324	5	D	D	NNP
10_1101-2020_06_17_156679	324	6	,	,	,
10_1101-2020_06_17_156679	324	7	Pedersen	Pedersen	NNP
10_1101-2020_06_17_156679	324	8	L.	L.	NNP
10_1101-2020_06_17_156679	324	9	Particle	Particle	NNP
10_1101-2020_06_17_156679	324	10	mesh	mesh	NN
10_1101-2020_06_17_156679	324	11	Ewald	Ewald	NNP
10_1101-2020_06_17_156679	324	12	:	:	:
10_1101-2020_06_17_156679	324	13	An	an	DT
10_1101-2020_06_17_156679	324	14	N⋅	n⋅	JJ
10_1101-2020_06_17_156679	324	15	log	log	NN
10_1101-2020_06_17_156679	324	16	(	(	-LRB-
10_1101-2020_06_17_156679	324	17	N	n	NN
10_1101-2020_06_17_156679	324	18	)	)	-RRB-
10_1101-2020_06_17_156679	324	19	method	method	NN
10_1101-2020_06_17_156679	324	20	for	for	IN
10_1101-2020_06_17_156679	324	21	Ewald	Ewald	NNP
10_1101-2020_06_17_156679	324	22	sums	sum	VBZ
10_1101-2020_06_17_156679	324	23	in	in	IN
10_1101-2020_06_17_156679	324	24	429	429	CD
10_1101-2020_06_17_156679	324	25	large	large	JJ
10_1101-2020_06_17_156679	324	26	systems	system	NNS
10_1101-2020_06_17_156679	324	27	.	.	.
10_1101-2020_06_17_156679	325	1	J	J	NNP
10_1101-2020_06_17_156679	325	2	Chem	Chem	NNP
10_1101-2020_06_17_156679	325	3	Phys	Phys	NNP
10_1101-2020_06_17_156679	325	4	.	.	.
10_1101-2020_06_17_156679	326	1	1993;98(12):10089	1993;98(12):10089	CD
10_1101-2020_06_17_156679	326	2	-	-	SYM
10_1101-2020_06_17_156679	326	3	92	92	CD
10_1101-2020_06_17_156679	326	4	.	.	.
10_1101-2020_06_17_156679	327	1	430	430	CD
10_1101-2020_06_17_156679	327	2	30	30	CD
10_1101-2020_06_17_156679	327	3	.	.	.
10_1101-2020_06_17_156679	328	1	Michaud	Michaud	NNP
10_1101-2020_06_17_156679	328	2	-	-	HYPH
10_1101-2020_06_17_156679	328	3	Agrawal	Agrawal	NNP
10_1101-2020_06_17_156679	328	4	N	N	NNP
10_1101-2020_06_17_156679	328	5	,	,	,
10_1101-2020_06_17_156679	328	6	Denning	Denning	NNP
10_1101-2020_06_17_156679	328	7	EJ	EJ	NNP
10_1101-2020_06_17_156679	328	8	,	,	,
10_1101-2020_06_17_156679	328	9	Woolf	Woolf	NNP
10_1101-2020_06_17_156679	328	10	TB	TB	NNP
10_1101-2020_06_17_156679	328	11	,	,	,
10_1101-2020_06_17_156679	328	12	Beckstein	Beckstein	NNP
10_1101-2020_06_17_156679	328	13	O.	O.	NNP
10_1101-2020_06_17_156679	328	14	MDAnalysis	MDAnalysis	NNP
10_1101-2020_06_17_156679	328	15	:	:	:
10_1101-2020_06_17_156679	328	16	a	a	DT
10_1101-2020_06_17_156679	328	17	toolkit	toolkit	NN
10_1101-2020_06_17_156679	328	18	for	for	IN
10_1101-2020_06_17_156679	328	19	the	the	DT
10_1101-2020_06_17_156679	328	20	431	431	CD
10_1101-2020_06_17_156679	328	21	analysis	analysis	NN
10_1101-2020_06_17_156679	328	22	of	of	IN
10_1101-2020_06_17_156679	328	23	molecular	molecular	JJ
10_1101-2020_06_17_156679	328	24	dynamics	dynamic	NNS
10_1101-2020_06_17_156679	328	25	simulations	simulation	NNS
10_1101-2020_06_17_156679	328	26	.	.	.
10_1101-2020_06_17_156679	329	1	J	J	NNP
10_1101-2020_06_17_156679	329	2	Comput	Comput	NNP
10_1101-2020_06_17_156679	329	3	Chem	Chem	NNP
10_1101-2020_06_17_156679	329	4	.	.	.
10_1101-2020_06_17_156679	330	1	2011;32(10):2319	2011;32(10):2319	CD
10_1101-2020_06_17_156679	330	2	-	-	SYM
10_1101-2020_06_17_156679	330	3	27	27	CD
10_1101-2020_06_17_156679	330	4	.	.	.
10_1101-2020_06_17_156679	331	1	432	432	CD
10_1101-2020_06_17_156679	331	2	31	31	CD
10_1101-2020_06_17_156679	331	3	.	.	.
10_1101-2020_06_17_156679	332	1	Gowers	gower	NNS
10_1101-2020_06_17_156679	332	2	RJ	RJ	NNP
10_1101-2020_06_17_156679	332	3	,	,	,
10_1101-2020_06_17_156679	332	4	Linke	Linke	NNP
10_1101-2020_06_17_156679	332	5	M	M	NNP
10_1101-2020_06_17_156679	332	6	,	,	,
10_1101-2020_06_17_156679	332	7	Barnoud	Barnoud	NNP
10_1101-2020_06_17_156679	332	8	J	J	NNP
10_1101-2020_06_17_156679	332	9	,	,	,
10_1101-2020_06_17_156679	332	10	Reddy	Reddy	NNP
10_1101-2020_06_17_156679	332	11	TJE	TJE	NNP
10_1101-2020_06_17_156679	332	12	,	,	,
10_1101-2020_06_17_156679	332	13	Melo	Melo	NNP
10_1101-2020_06_17_156679	332	14	MN	MN	NNP
10_1101-2020_06_17_156679	332	15	,	,	,
10_1101-2020_06_17_156679	332	16	Seyler	Seyler	NNP
10_1101-2020_06_17_156679	332	17	SL	SL	NNP
10_1101-2020_06_17_156679	332	18	,	,	,
10_1101-2020_06_17_156679	332	19	et	et	NNP
10_1101-2020_06_17_156679	332	20	al	al	NNP
10_1101-2020_06_17_156679	332	21	.	.	NNP
10_1101-2020_06_17_156679	332	22	,	,	,
10_1101-2020_06_17_156679	332	23	editors	editor	NNS
10_1101-2020_06_17_156679	332	24	.	.	.
10_1101-2020_06_17_156679	333	1	MDAnalysis	mdanalysis	NN
10_1101-2020_06_17_156679	333	2	:	:	:
10_1101-2020_06_17_156679	333	3	A	a	DT
10_1101-2020_06_17_156679	333	4	433	433	CD
10_1101-2020_06_17_156679	333	5	Python	Python	NNP
10_1101-2020_06_17_156679	333	6	package	package	NN
10_1101-2020_06_17_156679	333	7	for	for	IN
10_1101-2020_06_17_156679	333	8	the	the	DT
10_1101-2020_06_17_156679	333	9	rapid	rapid	JJ
10_1101-2020_06_17_156679	333	10	analysis	analysis	NN
10_1101-2020_06_17_156679	333	11	of	of	IN
10_1101-2020_06_17_156679	333	12	molecular	molecular	JJ
10_1101-2020_06_17_156679	333	13	dynamics	dynamic	NNS
10_1101-2020_06_17_156679	333	14	simulations	simulation	NNS
10_1101-2020_06_17_156679	333	15	.	.	.
10_1101-2020_06_17_156679	334	1	15th	15th	NNP
10_1101-2020_06_17_156679	334	2	Python	Python	NNP
10_1101-2020_06_17_156679	334	3	in	in	IN
10_1101-2020_06_17_156679	334	4	Science	Science	NNP
10_1101-2020_06_17_156679	334	5	434	434	CD
10_1101-2020_06_17_156679	334	6	Conference	Conference	NNP
10_1101-2020_06_17_156679	334	7	;	;	:
10_1101-2020_06_17_156679	334	8	2016	2016	CD
10_1101-2020_06_17_156679	334	9	;	;	:
10_1101-2020_06_17_156679	334	10	Austin	Austin	NNP
10_1101-2020_06_17_156679	334	11	,	,	,
10_1101-2020_06_17_156679	334	12	TX	TX	NNP
10_1101-2020_06_17_156679	334	13	.	.	.
10_1101-2020_06_17_156679	335	1	435	435	CD
10_1101-2020_06_17_156679	335	2	32	32	CD
10_1101-2020_06_17_156679	335	3	.	.	.
10_1101-2020_06_17_156679	336	1	DeLano	DeLano	NNP
10_1101-2020_06_17_156679	336	2	WL	WL	NNP
10_1101-2020_06_17_156679	336	3	.	.	.
10_1101-2020_06_17_156679	337	1	The	the	DT
10_1101-2020_06_17_156679	337	2	PyMOL	PyMOL	NNP
10_1101-2020_06_17_156679	337	3	Molecular	Molecular	NNP
10_1101-2020_06_17_156679	337	4	Graphics	Graphics	NNP
10_1101-2020_06_17_156679	337	5	System	System	NNP
10_1101-2020_06_17_156679	337	6	.	.	.
10_1101-2020_06_17_156679	338	1	DeLano	DeLano	NNP
10_1101-2020_06_17_156679	338	2	Scientific	Scientific	NNP
10_1101-2020_06_17_156679	338	3	,	,	,
10_1101-2020_06_17_156679	338	4	San	San	NNP
10_1101-2020_06_17_156679	338	5	Carlos	Carlos	NNP
10_1101-2020_06_17_156679	338	6	,	,	,
10_1101-2020_06_17_156679	338	7	CA	CA	NNP
10_1101-2020_06_17_156679	338	8	,	,	,
10_1101-2020_06_17_156679	338	9	USA	USA	NNP
10_1101-2020_06_17_156679	338	10	.	.	.
10_1101-2020_06_17_156679	339	1	436	436	CD
10_1101-2020_06_17_156679	339	2	http://www.pymol.org.2002	http://www.pymol.org.2002	CD
10_1101-2020_06_17_156679	339	3	.	.	.
10_1101-2020_06_17_156679	340	1	437	437	CD
10_1101-2020_06_17_156679	340	2	33	33	CD
10_1101-2020_06_17_156679	340	3	.	.	.
10_1101-2020_06_17_156679	341	1	Collaborative	Collaborative	NNP
10_1101-2020_06_17_156679	341	2	Drug	Drug	NNP
10_1101-2020_06_17_156679	341	3	Discovery	Discovery	NNP
10_1101-2020_06_17_156679	341	4	database	database	NN
10_1101-2020_06_17_156679	341	5	public	public	JJ
10_1101-2020_06_17_156679	341	6	access	access	NN
10_1101-2020_06_17_156679	341	7	2020	2020	CD
10_1101-2020_06_17_156679	341	8	[	[	-LRB-
10_1101-2020_06_17_156679	341	9	Available	available	JJ
10_1101-2020_06_17_156679	341	10	from	from	IN
10_1101-2020_06_17_156679	341	11	:	:	:
10_1101-2020_06_17_156679	341	12	438	438	CD
10_1101-2020_06_17_156679	341	13	https://www.collaborativedrug.com/public-access/.	https://www.collaborativedrug.com/public-access/.	.
10_1101-2020_06_17_156679	342	1	439	439	CD
10_1101-2020_06_17_156679	342	2	34	34	CD
10_1101-2020_06_17_156679	342	3	.	.	.
10_1101-2020_06_17_156679	343	1	Grum	Grum	NNP
10_1101-2020_06_17_156679	343	2	-	-	HYPH
10_1101-2020_06_17_156679	343	3	Tokars	Tokars	NNP
10_1101-2020_06_17_156679	343	4	V	V	NNP
10_1101-2020_06_17_156679	343	5	,	,	,
10_1101-2020_06_17_156679	343	6	Ratia	Ratia	NNP
10_1101-2020_06_17_156679	343	7	K	K	NNP
10_1101-2020_06_17_156679	343	8	,	,	,
10_1101-2020_06_17_156679	343	9	Begaye	Begaye	NNP
10_1101-2020_06_17_156679	343	10	A	A	NNP
10_1101-2020_06_17_156679	343	11	,	,	,
10_1101-2020_06_17_156679	343	12	Baker	Baker	NNP
10_1101-2020_06_17_156679	343	13	SC	SC	NNP
10_1101-2020_06_17_156679	343	14	,	,	,
10_1101-2020_06_17_156679	343	15	Mesecar	Mesecar	NNP
10_1101-2020_06_17_156679	343	16	AD	AD	NNP
10_1101-2020_06_17_156679	343	17	.	.	.
10_1101-2020_06_17_156679	344	1	Evaluating	evaluate	VBG
10_1101-2020_06_17_156679	344	2	the	the	DT
10_1101-2020_06_17_156679	344	3	3C	3c	NN
10_1101-2020_06_17_156679	344	4	-	-	HYPH
10_1101-2020_06_17_156679	344	5	like	like	JJ
10_1101-2020_06_17_156679	344	6	protease	protease	NN
10_1101-2020_06_17_156679	344	7	440	440	CD
10_1101-2020_06_17_156679	344	8	activity	activity	NN
10_1101-2020_06_17_156679	344	9	of	of	IN
10_1101-2020_06_17_156679	344	10	SARS	SARS	NNP
10_1101-2020_06_17_156679	344	11	-	-	HYPH
10_1101-2020_06_17_156679	344	12	Coronavirus	Coronavirus	NNP
10_1101-2020_06_17_156679	344	13	:	:	:
10_1101-2020_06_17_156679	344	14	recommendations	recommendation	NNS
10_1101-2020_06_17_156679	344	15	for	for	IN
10_1101-2020_06_17_156679	344	16	standardized	standardized	JJ
10_1101-2020_06_17_156679	344	17	assays	assays	RB
10_1101-2020_06_17_156679	344	18	for	for	IN
10_1101-2020_06_17_156679	344	19	drug	drug	NN
10_1101-2020_06_17_156679	344	20	discovery	discovery	NN
10_1101-2020_06_17_156679	344	21	.	.	.
10_1101-2020_06_17_156679	345	1	Virus	virus	NN
10_1101-2020_06_17_156679	345	2	441	441	CD
10_1101-2020_06_17_156679	345	3	Res	Res	NNP
10_1101-2020_06_17_156679	345	4	.	.	.
10_1101-2020_06_17_156679	346	1	2008;133(1):63	2008;133(1):63	CD
10_1101-2020_06_17_156679	346	2	-	-	SYM
10_1101-2020_06_17_156679	346	3	73	73	CD
10_1101-2020_06_17_156679	346	4	.	.	.
10_1101-2020_06_17_156679	347	1	442	442	CD
10_1101-2020_06_17_156679	347	2	35	35	CD
10_1101-2020_06_17_156679	347	3	.	.	.
10_1101-2020_06_17_156679	348	1	Davies	davy	NNS
10_1101-2020_06_17_156679	348	2	TG	TG	NNP
10_1101-2020_06_17_156679	348	3	,	,	,
10_1101-2020_06_17_156679	348	4	Wixted	wixte	VBN
10_1101-2020_06_17_156679	348	5	WE	WE	NNP
10_1101-2020_06_17_156679	348	6	,	,	,
10_1101-2020_06_17_156679	348	7	Coyle	Coyle	NNP
10_1101-2020_06_17_156679	348	8	JE	JE	NNP
10_1101-2020_06_17_156679	348	9	,	,	,
10_1101-2020_06_17_156679	348	10	Griffiths	Griffiths	NNP
10_1101-2020_06_17_156679	348	11	-	-	HYPH
10_1101-2020_06_17_156679	348	12	Jones	Jones	NNP
10_1101-2020_06_17_156679	348	13	C	C	NNP
10_1101-2020_06_17_156679	348	14	,	,	,
10_1101-2020_06_17_156679	348	15	Hearn	Hearn	NNP
10_1101-2020_06_17_156679	348	16	K	K	NNP
10_1101-2020_06_17_156679	348	17	,	,	,
10_1101-2020_06_17_156679	348	18	McMenamin	McMenamin	NNP
10_1101-2020_06_17_156679	348	19	R	R	NNP
10_1101-2020_06_17_156679	348	20	,	,	,
10_1101-2020_06_17_156679	348	21	et	et	NNP
10_1101-2020_06_17_156679	348	22	al	al	NNP
10_1101-2020_06_17_156679	348	23	.	.	.
10_1101-2020_06_17_156679	349	1	Monoacidic	Monoacidic	NNP
10_1101-2020_06_17_156679	349	2	443	443	CD
10_1101-2020_06_17_156679	349	3	Inhibitors	Inhibitors	NNPS
10_1101-2020_06_17_156679	349	4	of	of	IN
10_1101-2020_06_17_156679	349	5	the	the	DT
10_1101-2020_06_17_156679	349	6	Kelch	Kelch	NNP
10_1101-2020_06_17_156679	349	7	-	-	HYPH
10_1101-2020_06_17_156679	349	8	like	like	JJ
10_1101-2020_06_17_156679	349	9	ECH	ECH	NNP
10_1101-2020_06_17_156679	349	10	-	-	HYPH
10_1101-2020_06_17_156679	349	11	Associated	Associated	NNP
10_1101-2020_06_17_156679	349	12	Protein	Protein	NNP
10_1101-2020_06_17_156679	349	13	1	1	CD
10_1101-2020_06_17_156679	349	14	:	:	:
10_1101-2020_06_17_156679	349	15	Nuclear	Nuclear	NNP
10_1101-2020_06_17_156679	349	16	Factor	Factor	NNP
10_1101-2020_06_17_156679	349	17	Erythroid	Erythroid	NNP
10_1101-2020_06_17_156679	349	18	2-Related	2-Related	NNP
10_1101-2020_06_17_156679	349	19	Factor	Factor	NNP
10_1101-2020_06_17_156679	349	20	2	2	CD
10_1101-2020_06_17_156679	349	21	444	444	CD
10_1101-2020_06_17_156679	349	22	(	(	-LRB-
10_1101-2020_06_17_156679	349	23	KEAP1	keap1	RB
10_1101-2020_06_17_156679	349	24	:	:	:
10_1101-2020_06_17_156679	349	25	NRF2	nrf2	JJ
10_1101-2020_06_17_156679	349	26	)	)	-RRB-
10_1101-2020_06_17_156679	349	27	Protein	Protein	NNP
10_1101-2020_06_17_156679	349	28	-	-	HYPH
10_1101-2020_06_17_156679	349	29	Protein	Protein	NNP
10_1101-2020_06_17_156679	349	30	Interaction	Interaction	NNP
10_1101-2020_06_17_156679	349	31	with	with	IN
10_1101-2020_06_17_156679	349	32	High	High	NNP
10_1101-2020_06_17_156679	349	33	Cell	Cell	NNP
10_1101-2020_06_17_156679	349	34	Potency	Potency	NNP
10_1101-2020_06_17_156679	349	35	Identified	identify	VBN
10_1101-2020_06_17_156679	349	36	by	by	IN
10_1101-2020_06_17_156679	349	37	Fragment	Fragment	NNP
10_1101-2020_06_17_156679	349	38	-	-	HYPH
10_1101-2020_06_17_156679	349	39	Based	base	VBN
10_1101-2020_06_17_156679	349	40	445	445	CD
10_1101-2020_06_17_156679	349	41	Discovery	Discovery	NNP
10_1101-2020_06_17_156679	349	42	.	.	.
10_1101-2020_06_17_156679	350	1	J	J	NNP
10_1101-2020_06_17_156679	350	2	Med	Med	NNP
10_1101-2020_06_17_156679	350	3	Chem	Chem	NNP
10_1101-2020_06_17_156679	350	4	.	.	.
10_1101-2020_06_17_156679	351	1	2016;59(8):3991	2016;59(8):3991	CD
10_1101-2020_06_17_156679	351	2	-	-	SYM
10_1101-2020_06_17_156679	351	3	4006	4006	CD
10_1101-2020_06_17_156679	351	4	.	.	.
10_1101-2020_06_17_156679	352	1	446	446	CD
10_1101-2020_06_17_156679	352	2	36	36	CD
10_1101-2020_06_17_156679	352	3	.	.	.
10_1101-2020_06_17_156679	353	1	Erlanson	Erlanson	NNP
10_1101-2020_06_17_156679	353	2	DA	DA	NNP
10_1101-2020_06_17_156679	353	3	,	,	,
10_1101-2020_06_17_156679	353	4	Fesik	Fesik	NNP
10_1101-2020_06_17_156679	353	5	SW	SW	NNP
10_1101-2020_06_17_156679	353	6	,	,	,
10_1101-2020_06_17_156679	353	7	Hubbard	Hubbard	NNP
10_1101-2020_06_17_156679	353	8	RE	RE	NNP
10_1101-2020_06_17_156679	353	9	,	,	,
10_1101-2020_06_17_156679	353	10	Jahnke	Jahnke	NNP
10_1101-2020_06_17_156679	353	11	W	W	NNP
10_1101-2020_06_17_156679	353	12	,	,	,
10_1101-2020_06_17_156679	353	13	Jhoti	Jhoti	NNP
10_1101-2020_06_17_156679	353	14	H.	H.	NNP
10_1101-2020_06_17_156679	353	15	Twenty	Twenty	NNP
10_1101-2020_06_17_156679	353	16	years	year	NNS
10_1101-2020_06_17_156679	353	17	on	on	IN
10_1101-2020_06_17_156679	353	18	:	:	:
10_1101-2020_06_17_156679	353	19	the	the	DT
10_1101-2020_06_17_156679	353	20	impact	impact	NN
10_1101-2020_06_17_156679	353	21	of	of	IN
10_1101-2020_06_17_156679	353	22	447	447	CD
10_1101-2020_06_17_156679	353	23	fragments	fragment	NNS
10_1101-2020_06_17_156679	353	24	on	on	IN
10_1101-2020_06_17_156679	353	25	drug	drug	NN
10_1101-2020_06_17_156679	353	26	discovery	discovery	NN
10_1101-2020_06_17_156679	353	27	.	.	.
10_1101-2020_06_17_156679	354	1	Nat	Nat	NNP
10_1101-2020_06_17_156679	354	2	Rev	Rev	NNP
10_1101-2020_06_17_156679	354	3	Drug	Drug	NNP
10_1101-2020_06_17_156679	354	4	Discov	Discov	NNP
10_1101-2020_06_17_156679	354	5	.	.	.
10_1101-2020_06_17_156679	355	1	2016;15(9):605	2016;15(9):605	CD
10_1101-2020_06_17_156679	355	2	-	-	SYM
10_1101-2020_06_17_156679	355	3	19	19	CD
10_1101-2020_06_17_156679	355	4	.	.	.
10_1101-2020_06_17_156679	356	1	448	448	CD
10_1101-2020_06_17_156679	356	2	449	449	CD
10_1101-2020_06_17_156679	356	3	450	450	CD
10_1101-2020_06_17_156679	356	4	.CC	.cc	CD
10_1101-2020_06_17_156679	356	5	-	-	:
10_1101-2020_06_17_156679	356	6	BY	by	IN
10_1101-2020_06_17_156679	356	7	4.0	4.0	CD
10_1101-2020_06_17_156679	356	8	International	International	NNP
10_1101-2020_06_17_156679	356	9	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	356	10	under	under	IN
10_1101-2020_06_17_156679	356	11	a	a	DT
10_1101-2020_06_17_156679	356	12	(	(	-LRB-
10_1101-2020_06_17_156679	356	13	which	which	WDT
10_1101-2020_06_17_156679	356	14	was	be	VBD
10_1101-2020_06_17_156679	356	15	not	not	RB
10_1101-2020_06_17_156679	356	16	certified	certify	VBN
10_1101-2020_06_17_156679	356	17	by	by	IN
10_1101-2020_06_17_156679	356	18	peer	peer	NN
10_1101-2020_06_17_156679	356	19	review	review	NN
10_1101-2020_06_17_156679	356	20	)	)	-RRB-
10_1101-2020_06_17_156679	356	21	is	be	VBZ
10_1101-2020_06_17_156679	356	22	the	the	DT
10_1101-2020_06_17_156679	356	23	author	author	NN
10_1101-2020_06_17_156679	356	24	/	/	SYM
10_1101-2020_06_17_156679	356	25	funder	funder	NN
10_1101-2020_06_17_156679	356	26	,	,	,
10_1101-2020_06_17_156679	356	27	who	who	WP
10_1101-2020_06_17_156679	356	28	has	have	VBZ
10_1101-2020_06_17_156679	356	29	granted	grant	VBN
10_1101-2020_06_17_156679	356	30	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	356	31	a	a	DT
10_1101-2020_06_17_156679	356	32	license	license	NN
10_1101-2020_06_17_156679	356	33	to	to	TO
10_1101-2020_06_17_156679	356	34	display	display	VB
10_1101-2020_06_17_156679	356	35	the	the	DT
10_1101-2020_06_17_156679	356	36	preprint	preprint	NN
10_1101-2020_06_17_156679	356	37	in	in	IN
10_1101-2020_06_17_156679	356	38	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	356	39	.	.	.
10_1101-2020_06_17_156679	357	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	357	2	is	be	VBZ
10_1101-2020_06_17_156679	357	3	made	make	VBN
10_1101-2020_06_17_156679	357	4	The	the	DT
10_1101-2020_06_17_156679	357	5	copyright	copyright	NN
10_1101-2020_06_17_156679	357	6	holder	holder	NN
10_1101-2020_06_17_156679	357	7	for	for	IN
10_1101-2020_06_17_156679	357	8	this	this	DT
10_1101-2020_06_17_156679	357	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	357	10	version	version	NN
10_1101-2020_06_17_156679	357	11	posted	post	VBD
10_1101-2020_06_17_156679	357	12	January	January	NNP
10_1101-2020_06_17_156679	357	13	6	6	CD
10_1101-2020_06_17_156679	357	14	,	,	,
10_1101-2020_06_17_156679	357	15	2021	2021	CD
10_1101-2020_06_17_156679	357	16	.	.	.
10_1101-2020_06_17_156679	357	17	;	;	:
10_1101-2020_06_17_156679	357	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	357	19	:	:	:
10_1101-2020_06_17_156679	357	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	357	21	preprint	preprint	NN
10_1101-2020_06_17_156679	357	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	NN
10_1101-2020_06_17_156679	357	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	357	24	16	16	CD
10_1101-2020_06_17_156679	357	25	Acknowledgements	acknowledgement	NNS
10_1101-2020_06_17_156679	357	26	451	451	CD
10_1101-2020_06_17_156679	357	27	We	-PRON-	PRP
10_1101-2020_06_17_156679	357	28	are	be	VBP
10_1101-2020_06_17_156679	357	29	grateful	grateful	JJ
10_1101-2020_06_17_156679	357	30	to	to	IN
10_1101-2020_06_17_156679	357	31	Nick	Nick	NNP
10_1101-2020_06_17_156679	357	32	Soffe	Soffe	NNP
10_1101-2020_06_17_156679	357	33	for	for	IN
10_1101-2020_06_17_156679	357	34	maintenance	maintenance	NN
10_1101-2020_06_17_156679	357	35	of	of	IN
10_1101-2020_06_17_156679	357	36	the	the	DT
10_1101-2020_06_17_156679	357	37	Oxford	Oxford	NNP
10_1101-2020_06_17_156679	357	38	Biochemistry	Biochemistry	NNP
10_1101-2020_06_17_156679	357	39	solution	solution	NN
10_1101-2020_06_17_156679	357	40	NMR	NMR	NNP
10_1101-2020_06_17_156679	357	41	facility	facility	NN
10_1101-2020_06_17_156679	357	42	,	,	,
10_1101-2020_06_17_156679	357	43	452	452	CD
10_1101-2020_06_17_156679	357	44	to	to	IN
10_1101-2020_06_17_156679	357	45	Claire	Claire	NNP
10_1101-2020_06_17_156679	357	46	Strain	Strain	NNP
10_1101-2020_06_17_156679	357	47	-	-	HYPH
10_1101-2020_06_17_156679	357	48	Damerell	Damerell	NNP
10_1101-2020_06_17_156679	357	49	,	,	,
10_1101-2020_06_17_156679	357	50	Petra	Petra	NNP
10_1101-2020_06_17_156679	357	51	Lukacik	Lukacik	NNP
10_1101-2020_06_17_156679	357	52	and	and	CC
10_1101-2020_06_17_156679	357	53	Martin	Martin	NNP
10_1101-2020_06_17_156679	357	54	A.	A.	NNP
10_1101-2020_06_17_156679	357	55	Walsh	Walsh	NNP
10_1101-2020_06_17_156679	357	56	for	for	IN
10_1101-2020_06_17_156679	357	57	advice	advice	NN
10_1101-2020_06_17_156679	357	58	on	on	IN
10_1101-2020_06_17_156679	357	59	Mpro	mpro	JJ
10_1101-2020_06_17_156679	357	60	production	production	NN
10_1101-2020_06_17_156679	357	61	,	,	,
10_1101-2020_06_17_156679	357	62	to	to	IN
10_1101-2020_06_17_156679	357	63	453	453	CD
10_1101-2020_06_17_156679	357	64	Anthony	Anthony	NNP
10_1101-2020_06_17_156679	357	65	Aimon	Aimon	NNP
10_1101-2020_06_17_156679	357	66	and	and	CC
10_1101-2020_06_17_156679	357	67	Frank	Frank	NNP
10_1101-2020_06_17_156679	357	68	von	von	NNP
10_1101-2020_06_17_156679	357	69	Delft	Delft	NNP
10_1101-2020_06_17_156679	357	70	for	for	IN
10_1101-2020_06_17_156679	357	71	providing	provide	VBG
10_1101-2020_06_17_156679	357	72	the	the	DT
10_1101-2020_06_17_156679	357	73	DSI	DSI	NNP
10_1101-2020_06_17_156679	357	74	-	-	HYPH
10_1101-2020_06_17_156679	357	75	poised	poise	VBN
10_1101-2020_06_17_156679	357	76	fragment	fragment	NN
10_1101-2020_06_17_156679	357	77	library	library	NN
10_1101-2020_06_17_156679	357	78	,	,	,
10_1101-2020_06_17_156679	357	79	to	to	IN
10_1101-2020_06_17_156679	357	80	Adrián	Adrián	NNP
10_1101-2020_06_17_156679	357	81	García	García	NNP
10_1101-2020_06_17_156679	357	82	,	,	,
10_1101-2020_06_17_156679	357	83	454	454	CD
10_1101-2020_06_17_156679	357	84	Nil	Nil	NNP
10_1101-2020_06_17_156679	357	85	Casajuana	Casajuana	NNPS
10_1101-2020_06_17_156679	357	86	and	and	CC
10_1101-2020_06_17_156679	357	87	Clàudia	Clàudia	NNP
10_1101-2020_06_17_156679	357	88	Llinàs	Llinàs	NNP
10_1101-2020_06_17_156679	357	89	del	del	NN
10_1101-2020_06_17_156679	357	90	Torrent	Torrent	NNP
10_1101-2020_06_17_156679	357	91	for	for	IN
10_1101-2020_06_17_156679	357	92	advice	advice	NN
10_1101-2020_06_17_156679	357	93	with	with	IN
10_1101-2020_06_17_156679	357	94	MD	MD	NNP
10_1101-2020_06_17_156679	357	95	analysis	analysis	NN
10_1101-2020_06_17_156679	357	96	tools	tool	NNS
10_1101-2020_06_17_156679	357	97	,	,	,
10_1101-2020_06_17_156679	357	98	and	and	CC
10_1101-2020_06_17_156679	357	99	to	to	IN
10_1101-2020_06_17_156679	357	100	Leonardo	Leonardo	NNP
10_1101-2020_06_17_156679	357	101	455	455	CD
10_1101-2020_06_17_156679	357	102	Pardo	Pardo	NNP
10_1101-2020_06_17_156679	357	103	for	for	IN
10_1101-2020_06_17_156679	357	104	providing	provide	VBG
10_1101-2020_06_17_156679	357	105	access	access	NN
10_1101-2020_06_17_156679	357	106	to	to	IN
10_1101-2020_06_17_156679	357	107	high	high	JJ
10_1101-2020_06_17_156679	357	108	-	-	HYPH
10_1101-2020_06_17_156679	357	109	performance	performance	NN
10_1101-2020_06_17_156679	357	110	computing	computing	NN
10_1101-2020_06_17_156679	357	111	facilities	facility	NNS
10_1101-2020_06_17_156679	357	112	.	.	.
10_1101-2020_06_17_156679	358	1	This	this	DT
10_1101-2020_06_17_156679	358	2	work	work	NN
10_1101-2020_06_17_156679	358	3	was	be	VBD
10_1101-2020_06_17_156679	358	4	supported	support	VBN
10_1101-2020_06_17_156679	358	5	by	by	IN
10_1101-2020_06_17_156679	358	6	456	456	CD
10_1101-2020_06_17_156679	358	7	philanthropic	philanthropic	JJ
10_1101-2020_06_17_156679	358	8	donations	donation	NNS
10_1101-2020_06_17_156679	358	9	to	to	IN
10_1101-2020_06_17_156679	358	10	the	the	DT
10_1101-2020_06_17_156679	358	11	University	University	NNP
10_1101-2020_06_17_156679	358	12	of	of	IN
10_1101-2020_06_17_156679	358	13	Oxford	Oxford	NNP
10_1101-2020_06_17_156679	358	14	COVID-19	COVID-19	NNP
10_1101-2020_06_17_156679	358	15	Research	Research	NNP
10_1101-2020_06_17_156679	358	16	Response	Response	NNP
10_1101-2020_06_17_156679	358	17	Fund	Fund	NNP
10_1101-2020_06_17_156679	358	18	and	and	CC
10_1101-2020_06_17_156679	358	19	the	the	DT
10_1101-2020_06_17_156679	358	20	457	457	CD
10_1101-2020_06_17_156679	358	21	Oxford	Oxford	NNP
10_1101-2020_06_17_156679	358	22	Glycobiology	Glycobiology	NNP
10_1101-2020_06_17_156679	358	23	Institute	Institute	NNP
10_1101-2020_06_17_156679	358	24	Endowment	Endowment	NNP
10_1101-2020_06_17_156679	358	25	.	.	.
10_1101-2020_06_17_156679	359	1	The	the	DT
10_1101-2020_06_17_156679	359	2	Oxford	Oxford	NNP
10_1101-2020_06_17_156679	359	3	Biochemistry	Biochemistry	NNP
10_1101-2020_06_17_156679	359	4	NMR	NMR	NNP
10_1101-2020_06_17_156679	359	5	facility	facility	NN
10_1101-2020_06_17_156679	359	6	was	be	VBD
10_1101-2020_06_17_156679	359	7	supported	support	VBN
10_1101-2020_06_17_156679	359	8	by	by	IN
10_1101-2020_06_17_156679	359	9	458	458	CD
10_1101-2020_06_17_156679	359	10	the	the	DT
10_1101-2020_06_17_156679	359	11	Wellcome	Wellcome	NNP
10_1101-2020_06_17_156679	359	12	Trust	Trust	NNP
10_1101-2020_06_17_156679	359	13	(	(	-LRB-
10_1101-2020_06_17_156679	359	14	094872	094872	CD
10_1101-2020_06_17_156679	359	15	/	/	SYM
10_1101-2020_06_17_156679	359	16	Z/10	Z/10	NNP
10_1101-2020_06_17_156679	359	17	/	/	SYM
10_1101-2020_06_17_156679	359	18	Z	Z	NNP
10_1101-2020_06_17_156679	359	19	)	)	-RRB-
10_1101-2020_06_17_156679	359	20	,	,	,
10_1101-2020_06_17_156679	359	21	the	the	DT
10_1101-2020_06_17_156679	359	22	Engineering	Engineering	NNP
10_1101-2020_06_17_156679	359	23	and	and	CC
10_1101-2020_06_17_156679	359	24	Physical	Physical	NNP
10_1101-2020_06_17_156679	359	25	Sciences	Sciences	NNPS
10_1101-2020_06_17_156679	359	26	Research	Research	NNP
10_1101-2020_06_17_156679	359	27	Council	Council	NNP
10_1101-2020_06_17_156679	359	28	459	459	CD
10_1101-2020_06_17_156679	359	29	(	(	-LRB-
10_1101-2020_06_17_156679	359	30	EP	EP	NNP
10_1101-2020_06_17_156679	359	31	/	/	SYM
10_1101-2020_06_17_156679	359	32	R029849/1	R029849/1	NNP
10_1101-2020_06_17_156679	359	33	)	)	-RRB-
10_1101-2020_06_17_156679	359	34	,	,	,
10_1101-2020_06_17_156679	359	35	the	the	DT
10_1101-2020_06_17_156679	359	36	Wellcome	Wellcome	NNP
10_1101-2020_06_17_156679	359	37	Institutional	Institutional	NNP
10_1101-2020_06_17_156679	359	38	Strategic	Strategic	NNP
10_1101-2020_06_17_156679	359	39	Support	Support	NNP
10_1101-2020_06_17_156679	359	40	Fund	Fund	NNP
10_1101-2020_06_17_156679	359	41	,	,	,
10_1101-2020_06_17_156679	359	42	the	the	DT
10_1101-2020_06_17_156679	359	43	EPA	EPA	NNP
10_1101-2020_06_17_156679	359	44	Cephalosporin	Cephalosporin	NNP
10_1101-2020_06_17_156679	359	45	Fund	Fund	NNP
10_1101-2020_06_17_156679	359	46	460	460	CD
10_1101-2020_06_17_156679	359	47	and	and	CC
10_1101-2020_06_17_156679	359	48	the	the	DT
10_1101-2020_06_17_156679	359	49	John	John	NNP
10_1101-2020_06_17_156679	359	50	Fell	Fell	NNP
10_1101-2020_06_17_156679	359	51	OUP	OUP	NNP
10_1101-2020_06_17_156679	359	52	Research	Research	NNP
10_1101-2020_06_17_156679	359	53	Fund	Fund	NNP
10_1101-2020_06_17_156679	359	54	.	.	.
10_1101-2020_06_17_156679	360	1	This	this	DT
10_1101-2020_06_17_156679	360	2	work	work	NN
10_1101-2020_06_17_156679	360	3	was	be	VBD
10_1101-2020_06_17_156679	360	4	also	also	RB
10_1101-2020_06_17_156679	360	5	supported	support	VBN
10_1101-2020_06_17_156679	360	6	by	by	IN
10_1101-2020_06_17_156679	360	7	the	the	DT
10_1101-2020_06_17_156679	360	8	“	"	``
10_1101-2020_06_17_156679	360	9	Reinforcement	reinforcement	NN
10_1101-2020_06_17_156679	360	10	of	of	IN
10_1101-2020_06_17_156679	360	11	461	461	CD
10_1101-2020_06_17_156679	360	12	Postdoctoral	Postdoctoral	NNP
10_1101-2020_06_17_156679	360	13	Researchers	Researchers	NNPS
10_1101-2020_06_17_156679	360	14	-	-	HYPH
10_1101-2020_06_17_156679	360	15	2nd	2nd	NNP
10_1101-2020_06_17_156679	360	16	Cycle	cycle	NN
10_1101-2020_06_17_156679	360	17	”	"	''
10_1101-2020_06_17_156679	360	18	(	(	-LRB-
10_1101-2020_06_17_156679	360	19	MIS-5033021	MIS-5033021	NNP
10_1101-2020_06_17_156679	360	20	)	)	-RRB-
10_1101-2020_06_17_156679	360	21	,	,	,
10_1101-2020_06_17_156679	360	22	implemented	implement	VBN
10_1101-2020_06_17_156679	360	23	by	by	IN
10_1101-2020_06_17_156679	360	24	the	the	DT
10_1101-2020_06_17_156679	360	25	Greek	Greek	NNP
10_1101-2020_06_17_156679	360	26	State	State	NNP
10_1101-2020_06_17_156679	360	27	Scholarships	Scholarships	NNP
10_1101-2020_06_17_156679	360	28	462	462	CD
10_1101-2020_06_17_156679	360	29	Foundation	Foundation	NNP
10_1101-2020_06_17_156679	360	30	(	(	-LRB-
10_1101-2020_06_17_156679	360	31	ΙΚΥ	ΙΚΥ	NNP
10_1101-2020_06_17_156679	360	32	)	)	-RRB-
10_1101-2020_06_17_156679	360	33	.	.	.
10_1101-2020_06_17_156679	361	1	463	463	CD
10_1101-2020_06_17_156679	361	2	464	464	CD
10_1101-2020_06_17_156679	361	3	465	465	CD
10_1101-2020_06_17_156679	361	4	.CC	.cc	CD
10_1101-2020_06_17_156679	361	5	-	-	:
10_1101-2020_06_17_156679	361	6	BY	by	IN
10_1101-2020_06_17_156679	361	7	4.0	4.0	CD
10_1101-2020_06_17_156679	361	8	International	International	NNP
10_1101-2020_06_17_156679	361	9	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	361	10	under	under	IN
10_1101-2020_06_17_156679	361	11	a	a	DT
10_1101-2020_06_17_156679	361	12	(	(	-LRB-
10_1101-2020_06_17_156679	361	13	which	which	WDT
10_1101-2020_06_17_156679	361	14	was	be	VBD
10_1101-2020_06_17_156679	361	15	not	not	RB
10_1101-2020_06_17_156679	361	16	certified	certify	VBN
10_1101-2020_06_17_156679	361	17	by	by	IN
10_1101-2020_06_17_156679	361	18	peer	peer	NN
10_1101-2020_06_17_156679	361	19	review	review	NN
10_1101-2020_06_17_156679	361	20	)	)	-RRB-
10_1101-2020_06_17_156679	361	21	is	be	VBZ
10_1101-2020_06_17_156679	361	22	the	the	DT
10_1101-2020_06_17_156679	361	23	author	author	NN
10_1101-2020_06_17_156679	361	24	/	/	SYM
10_1101-2020_06_17_156679	361	25	funder	funder	NN
10_1101-2020_06_17_156679	361	26	,	,	,
10_1101-2020_06_17_156679	361	27	who	who	WP
10_1101-2020_06_17_156679	361	28	has	have	VBZ
10_1101-2020_06_17_156679	361	29	granted	grant	VBN
10_1101-2020_06_17_156679	361	30	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	361	31	a	a	DT
10_1101-2020_06_17_156679	361	32	license	license	NN
10_1101-2020_06_17_156679	361	33	to	to	TO
10_1101-2020_06_17_156679	361	34	display	display	VB
10_1101-2020_06_17_156679	361	35	the	the	DT
10_1101-2020_06_17_156679	361	36	preprint	preprint	NN
10_1101-2020_06_17_156679	361	37	in	in	IN
10_1101-2020_06_17_156679	361	38	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	361	39	.	.	.
10_1101-2020_06_17_156679	362	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	362	2	is	be	VBZ
10_1101-2020_06_17_156679	362	3	made	make	VBN
10_1101-2020_06_17_156679	362	4	The	the	DT
10_1101-2020_06_17_156679	362	5	copyright	copyright	NN
10_1101-2020_06_17_156679	362	6	holder	holder	NN
10_1101-2020_06_17_156679	362	7	for	for	IN
10_1101-2020_06_17_156679	362	8	this	this	DT
10_1101-2020_06_17_156679	362	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	362	10	version	version	NN
10_1101-2020_06_17_156679	362	11	posted	post	VBD
10_1101-2020_06_17_156679	362	12	January	January	NNP
10_1101-2020_06_17_156679	362	13	6	6	CD
10_1101-2020_06_17_156679	362	14	,	,	,
10_1101-2020_06_17_156679	362	15	2021	2021	CD
10_1101-2020_06_17_156679	362	16	.	.	.
10_1101-2020_06_17_156679	362	17	;	;	:
10_1101-2020_06_17_156679	362	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	362	19	:	:	:
10_1101-2020_06_17_156679	362	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	362	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	362	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	362	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	362	24	17	17	CD
10_1101-2020_06_17_156679	362	25	Figure	figure	NN
10_1101-2020_06_17_156679	362	26	1	1	CD
10_1101-2020_06_17_156679	362	27	:	:	:
10_1101-2020_06_17_156679	362	28	1D	1D	NNP
10_1101-2020_06_17_156679	362	29	and	and	CC
10_1101-2020_06_17_156679	362	30	STD	STD	NNP
10_1101-2020_06_17_156679	362	31	-	-	HYPH
10_1101-2020_06_17_156679	362	32	NMR	NMR	NNP
10_1101-2020_06_17_156679	362	33	spectra	spectra	NN
10_1101-2020_06_17_156679	362	34	of	of	IN
10_1101-2020_06_17_156679	362	35	SARS	SARS	NNP
10_1101-2020_06_17_156679	362	36	-	-	HYPH
10_1101-2020_06_17_156679	362	37	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	362	38	M	M	NNP
10_1101-2020_06_17_156679	362	39	pro	pro	NN
10_1101-2020_06_17_156679	362	40	.	.	.
10_1101-2020_06_17_156679	363	1	A	a	LS
10_1101-2020_06_17_156679	363	2	)	)	-RRB-
10_1101-2020_06_17_156679	363	3	Methyl	methyl	NN
10_1101-2020_06_17_156679	363	4	regions	region	NNS
10_1101-2020_06_17_156679	363	5	from	from	IN
10_1101-2020_06_17_156679	363	6	1H	1h	JJ
10_1101-2020_06_17_156679	363	7	NMR	NMR	NNP
10_1101-2020_06_17_156679	363	8	spectra	spectra	NN
10_1101-2020_06_17_156679	363	9	of	of	IN
10_1101-2020_06_17_156679	363	10	466	466	CD
10_1101-2020_06_17_156679	363	11	recombinant	recombinant	JJ
10_1101-2020_06_17_156679	363	12	SARS	SARS	NNP
10_1101-2020_06_17_156679	363	13	-	-	HYPH
10_1101-2020_06_17_156679	363	14	CoV-2	CoV-2	NNP
10_1101-2020_06_17_156679	363	15	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	363	16	.	.	.
10_1101-2020_06_17_156679	364	1	The	the	DT
10_1101-2020_06_17_156679	364	2	spectrum	spectrum	NN
10_1101-2020_06_17_156679	364	3	on	on	IN
10_1101-2020_06_17_156679	364	4	the	the	DT
10_1101-2020_06_17_156679	364	5	left	left	NN
10_1101-2020_06_17_156679	364	6	was	be	VBD
10_1101-2020_06_17_156679	364	7	recorded	record	VBN
10_1101-2020_06_17_156679	364	8	from	from	IN
10_1101-2020_06_17_156679	364	9	a	a	DT
10_1101-2020_06_17_156679	364	10	10	10	CD
10_1101-2020_06_17_156679	364	11	μM	μm	NN
10_1101-2020_06_17_156679	364	12	protein	protein	NN
10_1101-2020_06_17_156679	364	13	467	467	CD
10_1101-2020_06_17_156679	364	14	concentration	concentration	NN
10_1101-2020_06_17_156679	364	15	sample	sample	NN
10_1101-2020_06_17_156679	364	16	in	in	IN
10_1101-2020_06_17_156679	364	17	a	a	DT
10_1101-2020_06_17_156679	364	18	5	5	CD
10_1101-2020_06_17_156679	364	19	mm	mm	NN
10_1101-2020_06_17_156679	364	20	NMR	NMR	NNP
10_1101-2020_06_17_156679	364	21	tube	tube	NN
10_1101-2020_06_17_156679	364	22	at	at	IN
10_1101-2020_06_17_156679	364	23	25	25	CD
10_1101-2020_06_17_156679	364	24	oC	oC	NNP
10_1101-2020_06_17_156679	364	25	using	use	VBG
10_1101-2020_06_17_156679	364	26	an	an	DT
10_1101-2020_06_17_156679	364	27	excitation	excitation	NN
10_1101-2020_06_17_156679	364	28	sculpting	sculpt	VBG
10_1101-2020_06_17_156679	364	29	water	water	NN
10_1101-2020_06_17_156679	364	30	-	-	HYPH
10_1101-2020_06_17_156679	364	31	suppression	suppression	NN
10_1101-2020_06_17_156679	364	32	468	468	CD
10_1101-2020_06_17_156679	364	33	method	method	NN
10_1101-2020_06_17_156679	364	34	(	(	-LRB-
10_1101-2020_06_17_156679	364	35	24	24	CD
10_1101-2020_06_17_156679	364	36	)	)	-RRB-
10_1101-2020_06_17_156679	364	37	.	.	.
10_1101-2020_06_17_156679	365	1	512	512	CD
10_1101-2020_06_17_156679	365	2	acquisitions	acquisition	NNS
10_1101-2020_06_17_156679	365	3	with	with	IN
10_1101-2020_06_17_156679	365	4	recycle	recycle	NN
10_1101-2020_06_17_156679	365	5	delay	delay	NN
10_1101-2020_06_17_156679	365	6	of	of	IN
10_1101-2020_06_17_156679	365	7	1.25	1.25	CD
10_1101-2020_06_17_156679	365	8	sec	sec	NNP
10_1101-2020_06_17_156679	365	9	were	be	VBD
10_1101-2020_06_17_156679	365	10	averaged	average	VBN
10_1101-2020_06_17_156679	365	11	,	,	,
10_1101-2020_06_17_156679	365	12	for	for	IN
10_1101-2020_06_17_156679	365	13	a	a	DT
10_1101-2020_06_17_156679	365	14	total	total	JJ
10_1101-2020_06_17_156679	365	15	experiment	experiment	NN
10_1101-2020_06_17_156679	365	16	469	469	CD
10_1101-2020_06_17_156679	365	17	time	time	NN
10_1101-2020_06_17_156679	365	18	of	of	IN
10_1101-2020_06_17_156679	365	19	just	just	RB
10_1101-2020_06_17_156679	365	20	over	over	IN
10_1101-2020_06_17_156679	365	21	10	10	CD
10_1101-2020_06_17_156679	365	22	min	min	NN
10_1101-2020_06_17_156679	365	23	.	.	.
10_1101-2020_06_17_156679	366	1	The	the	DT
10_1101-2020_06_17_156679	366	2	spectrum	spectrum	NN
10_1101-2020_06_17_156679	366	3	on	on	IN
10_1101-2020_06_17_156679	366	4	the	the	DT
10_1101-2020_06_17_156679	366	5	right	right	NN
10_1101-2020_06_17_156679	366	6	was	be	VBD
10_1101-2020_06_17_156679	366	7	recorded	record	VBN
10_1101-2020_06_17_156679	366	8	from	from	IN
10_1101-2020_06_17_156679	366	9	a	a	DT
10_1101-2020_06_17_156679	366	10	10	10	CD
10_1101-2020_06_17_156679	366	11	μM	μM	NNP
10_1101-2020_06_17_156679	366	12	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	366	13	sample	sample	NN
10_1101-2020_06_17_156679	366	14	in	in	IN
10_1101-2020_06_17_156679	366	15	a	a	DT
10_1101-2020_06_17_156679	366	16	3	3	CD
10_1101-2020_06_17_156679	366	17	470	470	CD
10_1101-2020_06_17_156679	366	18	mm	mm	NN
10_1101-2020_06_17_156679	366	19	NMR	NMR	NNP
10_1101-2020_06_17_156679	366	20	tube	tube	NN
10_1101-2020_06_17_156679	366	21	at	at	IN
10_1101-2020_06_17_156679	366	22	10	10	CD
10_1101-2020_06_17_156679	366	23	oC	oc	CD
10_1101-2020_06_17_156679	366	24	,	,	,
10_1101-2020_06_17_156679	366	25	using	use	VBG
10_1101-2020_06_17_156679	366	26	the	the	DT
10_1101-2020_06_17_156679	366	27	same	same	JJ
10_1101-2020_06_17_156679	366	28	pulse	pulse	NN
10_1101-2020_06_17_156679	366	29	sequence	sequence	NN
10_1101-2020_06_17_156679	366	30	and	and	CC
10_1101-2020_06_17_156679	366	31	acquisition	acquisition	NN
10_1101-2020_06_17_156679	366	32	parameters	parameter	NNS
10_1101-2020_06_17_156679	366	33	.	.	.
10_1101-2020_06_17_156679	367	1	For	for	IN
10_1101-2020_06_17_156679	367	2	both	both	DT
10_1101-2020_06_17_156679	367	3	471	471	CD
10_1101-2020_06_17_156679	367	4	spectra	spectra	NN
10_1101-2020_06_17_156679	367	5	,	,	,
10_1101-2020_06_17_156679	367	6	data	datum	NNS
10_1101-2020_06_17_156679	367	7	were	be	VBD
10_1101-2020_06_17_156679	367	8	processed	process	VBN
10_1101-2020_06_17_156679	367	9	with	with	IN
10_1101-2020_06_17_156679	367	10	a	a	DT
10_1101-2020_06_17_156679	367	11	quadratic	quadratic	JJ
10_1101-2020_06_17_156679	367	12	sine	sine	NN
10_1101-2020_06_17_156679	367	13	function	function	NN
10_1101-2020_06_17_156679	367	14	prior	prior	RB
10_1101-2020_06_17_156679	367	15	to	to	IN
10_1101-2020_06_17_156679	367	16	Fourier	Fourier	NNP
10_1101-2020_06_17_156679	367	17	transformation	transformation	NN
10_1101-2020_06_17_156679	367	18	.	.	.
10_1101-2020_06_17_156679	368	1	Protein	protein	NN
10_1101-2020_06_17_156679	368	2	472	472	CD
10_1101-2020_06_17_156679	368	3	resonances	resonance	NNS
10_1101-2020_06_17_156679	368	4	are	be	VBP
10_1101-2020_06_17_156679	368	5	weaker	weak	JJR
10_1101-2020_06_17_156679	368	6	in	in	IN
10_1101-2020_06_17_156679	368	7	the	the	DT
10_1101-2020_06_17_156679	368	8	10	10	CD
10_1101-2020_06_17_156679	368	9	oC	oC	NNP
10_1101-2020_06_17_156679	368	10	spectrum	spectrum	NN
10_1101-2020_06_17_156679	368	11	due	due	IN
10_1101-2020_06_17_156679	368	12	to	to	IN
10_1101-2020_06_17_156679	368	13	lower	low	JJR
10_1101-2020_06_17_156679	368	14	temperature	temperature	NN
10_1101-2020_06_17_156679	368	15	and	and	CC
10_1101-2020_06_17_156679	368	16	the	the	DT
10_1101-2020_06_17_156679	368	17	reduced	reduce	VBN
10_1101-2020_06_17_156679	368	18	amount	amount	NN
10_1101-2020_06_17_156679	368	19	of	of	IN
10_1101-2020_06_17_156679	368	20	473	473	CD
10_1101-2020_06_17_156679	368	21	sample	sample	NN
10_1101-2020_06_17_156679	368	22	used	use	VBN
10_1101-2020_06_17_156679	368	23	for	for	IN
10_1101-2020_06_17_156679	368	24	acquisition	acquisition	NN
10_1101-2020_06_17_156679	368	25	in	in	IN
10_1101-2020_06_17_156679	368	26	the	the	DT
10_1101-2020_06_17_156679	368	27	smaller	small	JJR
10_1101-2020_06_17_156679	368	28	NMR	NMR	NNP
10_1101-2020_06_17_156679	368	29	tube	tube	NN
10_1101-2020_06_17_156679	368	30	.	.	.
10_1101-2020_06_17_156679	369	1	The	the	DT
10_1101-2020_06_17_156679	369	2	position	position	NN
10_1101-2020_06_17_156679	369	3	where	where	WRB
10_1101-2020_06_17_156679	369	4	on	on	IN
10_1101-2020_06_17_156679	369	5	-	-	HYPH
10_1101-2020_06_17_156679	369	6	resonance	resonance	NN
10_1101-2020_06_17_156679	369	7	irradiation	irradiation	NN
10_1101-2020_06_17_156679	369	8	474	474	CD
10_1101-2020_06_17_156679	369	9	was	be	VBD
10_1101-2020_06_17_156679	369	10	applied	apply	VBN
10_1101-2020_06_17_156679	369	11	for	for	IN
10_1101-2020_06_17_156679	369	12	STD	STD	NNP
10_1101-2020_06_17_156679	369	13	spectra	spectra	NNP
10_1101-2020_06_17_156679	369	14	is	be	VBZ
10_1101-2020_06_17_156679	369	15	indicated	indicate	VBN
10_1101-2020_06_17_156679	369	16	.	.	.
10_1101-2020_06_17_156679	370	1	B	b	NN
10_1101-2020_06_17_156679	370	2	)	)	-RRB-
10_1101-2020_06_17_156679	370	3	Vertically	vertically	RB
10_1101-2020_06_17_156679	370	4	offset	offset	VBP
10_1101-2020_06_17_156679	370	5	1H	1h	JJ
10_1101-2020_06_17_156679	370	6	STD	STD	NNP
10_1101-2020_06_17_156679	370	7	-	-	HYPH
10_1101-2020_06_17_156679	370	8	NMR	NMR	NNP
10_1101-2020_06_17_156679	370	9	spectra	spectra	NNP
10_1101-2020_06_17_156679	370	10	from	from	IN
10_1101-2020_06_17_156679	370	11	ligand	ligand	NNP
10_1101-2020_06_17_156679	370	12	x0434	x0434	NNP
10_1101-2020_06_17_156679	370	13	475	475	CD
10_1101-2020_06_17_156679	370	14	binding	bind	VBG
10_1101-2020_06_17_156679	370	15	to	to	IN
10_1101-2020_06_17_156679	370	16	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	370	17	.	.	.
10_1101-2020_06_17_156679	371	1	The	the	DT
10_1101-2020_06_17_156679	371	2	reference	reference	NN
10_1101-2020_06_17_156679	371	3	spectrum	spectrum	NN
10_1101-2020_06_17_156679	371	4	is	be	VBZ
10_1101-2020_06_17_156679	371	5	in	in	IN
10_1101-2020_06_17_156679	371	6	black	black	NN
10_1101-2020_06_17_156679	371	7	with	with	IN
10_1101-2020_06_17_156679	371	8	the	the	DT
10_1101-2020_06_17_156679	371	9	x0434	x0434	NNP
10_1101-2020_06_17_156679	371	10	,	,	,
10_1101-2020_06_17_156679	371	11	H2O	h2o	NN
10_1101-2020_06_17_156679	371	12	and	and	CC
10_1101-2020_06_17_156679	371	13	DMSO	DMSO	NNP
10_1101-2020_06_17_156679	371	14	1H	1H	NNP
10_1101-2020_06_17_156679	371	15	resonances	resonance	NNS
10_1101-2020_06_17_156679	371	16	476	476	CD
10_1101-2020_06_17_156679	371	17	indicated	indicate	VBD
10_1101-2020_06_17_156679	371	18	.	.	.
10_1101-2020_06_17_156679	372	1	The	the	DT
10_1101-2020_06_17_156679	372	2	STD	STD	NNP
10_1101-2020_06_17_156679	372	3	spectrum	spectrum	NN
10_1101-2020_06_17_156679	372	4	of	of	IN
10_1101-2020_06_17_156679	372	5	x0434	x0434	NNP
10_1101-2020_06_17_156679	372	6	in	in	IN
10_1101-2020_06_17_156679	372	7	the	the	DT
10_1101-2020_06_17_156679	372	8	presence	presence	NN
10_1101-2020_06_17_156679	372	9	of	of	IN
10_1101-2020_06_17_156679	372	10	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	372	11	is	be	VBZ
10_1101-2020_06_17_156679	372	12	shown	show	VBN
10_1101-2020_06_17_156679	372	13	in	in	IN
10_1101-2020_06_17_156679	372	14	red	red	JJ
10_1101-2020_06_17_156679	372	15	while	while	IN
10_1101-2020_06_17_156679	372	16	that	that	DT
10_1101-2020_06_17_156679	372	17	in	in	IN
10_1101-2020_06_17_156679	372	18	the	the	DT
10_1101-2020_06_17_156679	372	19	477	477	CD
10_1101-2020_06_17_156679	372	20	absence	absence	NN
10_1101-2020_06_17_156679	372	21	of	of	IN
10_1101-2020_06_17_156679	372	22	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	372	23	is	be	VBZ
10_1101-2020_06_17_156679	372	24	in	in	IN
10_1101-2020_06_17_156679	372	25	green	green	JJ
10_1101-2020_06_17_156679	372	26	.	.	.
10_1101-2020_06_17_156679	373	1	STD	STD	NNP
10_1101-2020_06_17_156679	373	2	spectra	spectra	NNP
10_1101-2020_06_17_156679	373	3	are	be	VBP
10_1101-2020_06_17_156679	373	4	scaled	scale	VBN
10_1101-2020_06_17_156679	373	5	up	up	RP
10_1101-2020_06_17_156679	373	6	64x	64x	NNS
10_1101-2020_06_17_156679	373	7	compared	compare	VBN
10_1101-2020_06_17_156679	373	8	to	to	IN
10_1101-2020_06_17_156679	373	9	the	the	DT
10_1101-2020_06_17_156679	373	10	reference	reference	NN
10_1101-2020_06_17_156679	373	11	spectrum	spectrum	NN
10_1101-2020_06_17_156679	373	12	.	.	.
10_1101-2020_06_17_156679	374	1	478	478	CD
10_1101-2020_06_17_156679	374	2	Bottom	bottom	JJ
10_1101-2020_06_17_156679	374	3	panels	panel	NNS
10_1101-2020_06_17_156679	374	4	correspond	correspond	VBP
10_1101-2020_06_17_156679	374	5	to	to	IN
10_1101-2020_06_17_156679	374	6	magnified	magnified	JJ
10_1101-2020_06_17_156679	374	7	views	view	NNS
10_1101-2020_06_17_156679	374	8	of	of	IN
10_1101-2020_06_17_156679	374	9	the	the	DT
10_1101-2020_06_17_156679	374	10	indicated	indicate	VBN
10_1101-2020_06_17_156679	374	11	spectral	spectral	JJ
10_1101-2020_06_17_156679	374	12	regions	region	NNS
10_1101-2020_06_17_156679	374	13	,	,	,
10_1101-2020_06_17_156679	374	14	with	with	IN
10_1101-2020_06_17_156679	374	15	x0434	x0434	NNP
10_1101-2020_06_17_156679	374	16	479	479	CD
10_1101-2020_06_17_156679	374	17	resonances	resonance	NNS
10_1101-2020_06_17_156679	374	18	assigned	assign	VBN
10_1101-2020_06_17_156679	374	19	to	to	IN
10_1101-2020_06_17_156679	374	20	chemical	chemical	JJ
10_1101-2020_06_17_156679	374	21	groups	group	NNS
10_1101-2020_06_17_156679	374	22	of	of	IN
10_1101-2020_06_17_156679	374	23	that	that	DT
10_1101-2020_06_17_156679	374	24	ligand	ligand	NN
10_1101-2020_06_17_156679	374	25	as	as	IN
10_1101-2020_06_17_156679	374	26	shown	show	VBN
10_1101-2020_06_17_156679	374	27	.	.	.
10_1101-2020_06_17_156679	375	1	480	480	CD
10_1101-2020_06_17_156679	375	2	481	481	CD
10_1101-2020_06_17_156679	375	3	Figure	figure	NN
10_1101-2020_06_17_156679	375	4	2	2	CD
10_1101-2020_06_17_156679	375	5	:	:	:
10_1101-2020_06_17_156679	375	6	Assessment	assessment	NN
10_1101-2020_06_17_156679	375	7	of	of	IN
10_1101-2020_06_17_156679	375	8	fragment	fragment	NN
10_1101-2020_06_17_156679	375	9	binding	bind	VBG
10_1101-2020_06_17_156679	375	10	to	to	IN
10_1101-2020_06_17_156679	375	11	M	M	NNP
10_1101-2020_06_17_156679	375	12	pro	pro	NN
10_1101-2020_06_17_156679	375	13	.	.	.
10_1101-2020_06_17_156679	376	1	A	a	LS
10_1101-2020_06_17_156679	376	2	)	)	-RRB-
10_1101-2020_06_17_156679	376	3	STDratio	stdratio	NN
10_1101-2020_06_17_156679	376	4	values	value	NNS
10_1101-2020_06_17_156679	376	5	for	for	IN
10_1101-2020_06_17_156679	376	6	chemical	chemical	NN
10_1101-2020_06_17_156679	376	7	fragments	fragment	NNS
10_1101-2020_06_17_156679	376	8	identified	identify	VBD
10_1101-2020_06_17_156679	376	9	482	482	CD
10_1101-2020_06_17_156679	376	10	by	by	IN
10_1101-2020_06_17_156679	376	11	crystallographic	crystallographic	JJ
10_1101-2020_06_17_156679	376	12	screening	screening	NN
10_1101-2020_06_17_156679	376	13	as	as	IN
10_1101-2020_06_17_156679	376	14	binding	bind	VBG
10_1101-2020_06_17_156679	376	15	to	to	IN
10_1101-2020_06_17_156679	376	16	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	376	17	(	(	-LRB-
10_1101-2020_06_17_156679	376	18	18	18	CD
10_1101-2020_06_17_156679	376	19	)	)	-RRB-
10_1101-2020_06_17_156679	376	20	.	.	.
10_1101-2020_06_17_156679	377	1	Ligands	ligand	NNS
10_1101-2020_06_17_156679	377	2	binding	bind	VBG
10_1101-2020_06_17_156679	377	3	to	to	IN
10_1101-2020_06_17_156679	377	4	the	the	DT
10_1101-2020_06_17_156679	377	5	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	377	6	active	active	JJ
10_1101-2020_06_17_156679	377	7	site	site	NN
10_1101-2020_06_17_156679	377	8	are	be	VBP
10_1101-2020_06_17_156679	377	9	483	483	CD
10_1101-2020_06_17_156679	377	10	coloured	colour	VBN
10_1101-2020_06_17_156679	377	11	orange	orange	NN
10_1101-2020_06_17_156679	377	12	,	,	,
10_1101-2020_06_17_156679	377	13	at	at	IN
10_1101-2020_06_17_156679	377	14	the	the	DT
10_1101-2020_06_17_156679	377	15	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	377	16	dimer	dimer	NN
10_1101-2020_06_17_156679	377	17	interface	interface	NN
10_1101-2020_06_17_156679	377	18	in	in	IN
10_1101-2020_06_17_156679	377	19	red	red	NN
10_1101-2020_06_17_156679	377	20	,	,	,
10_1101-2020_06_17_156679	377	21	and	and	CC
10_1101-2020_06_17_156679	377	22	elsewhere	elsewhere	RB
10_1101-2020_06_17_156679	377	23	on	on	IN
10_1101-2020_06_17_156679	377	24	the	the	DT
10_1101-2020_06_17_156679	377	25	protein	protein	NN
10_1101-2020_06_17_156679	377	26	surface	surface	NN
10_1101-2020_06_17_156679	377	27	in	in	IN
10_1101-2020_06_17_156679	377	28	blue	blue	NNP
10_1101-2020_06_17_156679	377	29	.	.	.
10_1101-2020_06_17_156679	378	1	B	b	NN
10_1101-2020_06_17_156679	378	2	)	)	-RRB-
10_1101-2020_06_17_156679	378	3	484	484	CD
10_1101-2020_06_17_156679	378	4	Overlay	Overlay	NNP
10_1101-2020_06_17_156679	378	5	of	of	IN
10_1101-2020_06_17_156679	378	6	STD	STD	NNP
10_1101-2020_06_17_156679	378	7	-	-	HYPH
10_1101-2020_06_17_156679	378	8	NMR	NMR	NNP
10_1101-2020_06_17_156679	378	9	spectra	spectra	NNP
10_1101-2020_06_17_156679	378	10	from	from	IN
10_1101-2020_06_17_156679	378	11	fragments	fragment	NNS
10_1101-2020_06_17_156679	378	12	x0305	x0305	NNP
10_1101-2020_06_17_156679	378	13	,	,	,
10_1101-2020_06_17_156679	378	14	x0387	x0387	NNP
10_1101-2020_06_17_156679	378	15	and	and	CC
10_1101-2020_06_17_156679	378	16	x434	x434	NNP
10_1101-2020_06_17_156679	378	17	,	,	,
10_1101-2020_06_17_156679	378	18	which	which	WDT
10_1101-2020_06_17_156679	378	19	bind	bind	VBP
10_1101-2020_06_17_156679	378	20	the	the	DT
10_1101-2020_06_17_156679	378	21	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	378	22	active	active	JJ
10_1101-2020_06_17_156679	378	23	site	site	NN
10_1101-2020_06_17_156679	378	24	,	,	,
10_1101-2020_06_17_156679	378	25	485	485	CD
10_1101-2020_06_17_156679	378	26	showing	show	VBG
10_1101-2020_06_17_156679	378	27	the	the	DT
10_1101-2020_06_17_156679	378	28	ligand	ligand	NNP
10_1101-2020_06_17_156679	378	29	aromatic	aromatic	NNP
10_1101-2020_06_17_156679	378	30	region	region	NN
10_1101-2020_06_17_156679	378	31	in	in	IN
10_1101-2020_06_17_156679	378	32	the	the	DT
10_1101-2020_06_17_156679	378	33	presence	presence	NN
10_1101-2020_06_17_156679	378	34	of	of	IN
10_1101-2020_06_17_156679	378	35	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	378	36	.	.	.
10_1101-2020_06_17_156679	379	1	Spectra	Spectra	NNP
10_1101-2020_06_17_156679	379	2	are	be	VBP
10_1101-2020_06_17_156679	379	3	colour	colour	NN
10_1101-2020_06_17_156679	379	4	coded	code	VBN
10_1101-2020_06_17_156679	379	5	per	per	IN
10_1101-2020_06_17_156679	379	6	ligand	ligand	NN
10_1101-2020_06_17_156679	379	7	as	as	IN
10_1101-2020_06_17_156679	379	8	486	486	CD
10_1101-2020_06_17_156679	379	9	indicated	indicate	VBD
10_1101-2020_06_17_156679	379	10	.	.	.
10_1101-2020_06_17_156679	380	1	As	as	IN
10_1101-2020_06_17_156679	380	2	seen	see	VBN
10_1101-2020_06_17_156679	380	3	,	,	,
10_1101-2020_06_17_156679	380	4	the	the	DT
10_1101-2020_06_17_156679	380	5	three	three	CD
10_1101-2020_06_17_156679	380	6	fragments	fragment	NNS
10_1101-2020_06_17_156679	380	7	yield	yield	VBP
10_1101-2020_06_17_156679	380	8	significantly	significantly	RB
10_1101-2020_06_17_156679	380	9	different	different	JJ
10_1101-2020_06_17_156679	380	10	STD	STD	NNP
10_1101-2020_06_17_156679	380	11	signal	signal	NN
10_1101-2020_06_17_156679	380	12	intensities	intensity	NNS
10_1101-2020_06_17_156679	380	13	captured	capture	VBN
10_1101-2020_06_17_156679	380	14	in	in	IN
10_1101-2020_06_17_156679	380	15	487	487	CD
10_1101-2020_06_17_156679	380	16	the	the	DT
10_1101-2020_06_17_156679	380	17	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	380	18	values	value	NNS
10_1101-2020_06_17_156679	380	19	shown	show	VBN
10_1101-2020_06_17_156679	380	20	in	in	IN
10_1101-2020_06_17_156679	380	21	(	(	-LRB-
10_1101-2020_06_17_156679	380	22	A	a	NN
10_1101-2020_06_17_156679	380	23	)	)	-RRB-
10_1101-2020_06_17_156679	380	24	.	.	.
10_1101-2020_06_17_156679	381	1	C	C	NNP
10_1101-2020_06_17_156679	381	2	)	)	-RRB-
10_1101-2020_06_17_156679	381	3	Overlay	overlay	NN
10_1101-2020_06_17_156679	381	4	of	of	IN
10_1101-2020_06_17_156679	381	5	reference	reference	NN
10_1101-2020_06_17_156679	381	6	spectra	spectra	NNP
10_1101-2020_06_17_156679	381	7	from	from	IN
10_1101-2020_06_17_156679	381	8	fragments	fragments	NNP
10_1101-2020_06_17_156679	381	9	x305	x305	NNP
10_1101-2020_06_17_156679	381	10	,	,	,
10_1101-2020_06_17_156679	381	11	x376	x376	NNP
10_1101-2020_06_17_156679	381	12	and	and	CC
10_1101-2020_06_17_156679	381	13	x540	x540	NNP
10_1101-2020_06_17_156679	381	14	,	,	,
10_1101-2020_06_17_156679	381	15	488	488	CD
10_1101-2020_06_17_156679	381	16	showing	show	VBG
10_1101-2020_06_17_156679	381	17	the	the	DT
10_1101-2020_06_17_156679	381	18	ligand	ligand	NNP
10_1101-2020_06_17_156679	381	19	aromatic	aromatic	NNP
10_1101-2020_06_17_156679	381	20	region	region	NN
10_1101-2020_06_17_156679	381	21	.	.	.
10_1101-2020_06_17_156679	382	1	Peak	peak	NN
10_1101-2020_06_17_156679	382	2	intensities	intensity	NNS
10_1101-2020_06_17_156679	382	3	vary	vary	VBP
10_1101-2020_06_17_156679	382	4	substantially	substantially	RB
10_1101-2020_06_17_156679	382	5	,	,	,
10_1101-2020_06_17_156679	382	6	suggesting	suggest	VBG
10_1101-2020_06_17_156679	382	7	significant	significant	JJ
10_1101-2020_06_17_156679	382	8	489	489	CD
10_1101-2020_06_17_156679	382	9	differences	difference	NNS
10_1101-2020_06_17_156679	382	10	in	in	IN
10_1101-2020_06_17_156679	382	11	ligand	ligand	NNP
10_1101-2020_06_17_156679	382	12	concentration	concentration	NN
10_1101-2020_06_17_156679	382	13	.	.	.
10_1101-2020_06_17_156679	383	1	490	490	CD
10_1101-2020_06_17_156679	383	2	491	491	CD
10_1101-2020_06_17_156679	383	3	Figure	figure	NN
10_1101-2020_06_17_156679	383	4	3	3	CD
10_1101-2020_06_17_156679	383	5	.	.	.
10_1101-2020_06_17_156679	384	1	STD	STD	NNP
10_1101-2020_06_17_156679	384	2	-	-	HYPH
10_1101-2020_06_17_156679	384	3	NMR	NMR	NNP
10_1101-2020_06_17_156679	384	4	of	of	IN
10_1101-2020_06_17_156679	384	5	COVID	COVID	NNP
10_1101-2020_06_17_156679	384	6	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	384	7	ligands	ligand	NNS
10_1101-2020_06_17_156679	384	8	binding	bind	VBG
10_1101-2020_06_17_156679	384	9	to	to	IN
10_1101-2020_06_17_156679	384	10	M	M	NNP
10_1101-2020_06_17_156679	384	11	pro	pro	NN
10_1101-2020_06_17_156679	384	12	.	.	.
10_1101-2020_06_17_156679	385	1	A	a	LS
10_1101-2020_06_17_156679	385	2	)	)	-RRB-
10_1101-2020_06_17_156679	385	3	Overlay	overlay	NN
10_1101-2020_06_17_156679	385	4	of	of	IN
10_1101-2020_06_17_156679	385	5	reference	reference	NN
10_1101-2020_06_17_156679	385	6	spectra	spectra	NNP
10_1101-2020_06_17_156679	385	7	from	from	IN
10_1101-2020_06_17_156679	385	8	492	492	CD
10_1101-2020_06_17_156679	385	9	the	the	DT
10_1101-2020_06_17_156679	385	10	indicated	indicate	VBN
10_1101-2020_06_17_156679	385	11	COVID	COVID	NNP
10_1101-2020_06_17_156679	385	12	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	385	13	ligands	ligand	NNS
10_1101-2020_06_17_156679	385	14	,	,	,
10_1101-2020_06_17_156679	385	15	showing	show	VBG
10_1101-2020_06_17_156679	385	16	the	the	DT
10_1101-2020_06_17_156679	385	17	ligand	ligand	NNP
10_1101-2020_06_17_156679	385	18	aromatic	aromatic	NNP
10_1101-2020_06_17_156679	385	19	region	region	NN
10_1101-2020_06_17_156679	385	20	in	in	IN
10_1101-2020_06_17_156679	385	21	each	each	DT
10_1101-2020_06_17_156679	385	22	case	case	NN
10_1101-2020_06_17_156679	385	23	.	.	.
10_1101-2020_06_17_156679	386	1	in	in	IN
10_1101-2020_06_17_156679	386	2	the	the	DT
10_1101-2020_06_17_156679	386	3	493	493	CD
10_1101-2020_06_17_156679	386	4	presence	presence	NN
10_1101-2020_06_17_156679	386	5	of	of	IN
10_1101-2020_06_17_156679	386	6	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	386	7	.	.	.
10_1101-2020_06_17_156679	387	1	Spectra	Spectra	NNP
10_1101-2020_06_17_156679	387	2	are	be	VBP
10_1101-2020_06_17_156679	387	3	colour	colour	NN
10_1101-2020_06_17_156679	387	4	coded	code	VBN
10_1101-2020_06_17_156679	387	5	per	per	IN
10_1101-2020_06_17_156679	387	6	ligand	ligand	NN
10_1101-2020_06_17_156679	387	7	as	as	IN
10_1101-2020_06_17_156679	387	8	indicated	indicate	VBN
10_1101-2020_06_17_156679	387	9	.	.	.
10_1101-2020_06_17_156679	388	1	As	as	IN
10_1101-2020_06_17_156679	388	2	seen	see	VBN
10_1101-2020_06_17_156679	388	3	,	,	,
10_1101-2020_06_17_156679	388	4	peak	peak	JJ
10_1101-2020_06_17_156679	388	5	intensities	intensity	NNS
10_1101-2020_06_17_156679	388	6	vary	vary	VBP
10_1101-2020_06_17_156679	388	7	494	494	CD
10_1101-2020_06_17_156679	388	8	substantially	substantially	RB
10_1101-2020_06_17_156679	388	9	,	,	,
10_1101-2020_06_17_156679	388	10	suggesting	suggest	VBG
10_1101-2020_06_17_156679	388	11	significant	significant	JJ
10_1101-2020_06_17_156679	388	12	differences	difference	NNS
10_1101-2020_06_17_156679	388	13	in	in	IN
10_1101-2020_06_17_156679	388	14	ligand	ligand	NNP
10_1101-2020_06_17_156679	388	15	concentration	concentration	NN
10_1101-2020_06_17_156679	388	16	.	.	.
10_1101-2020_06_17_156679	389	1	Peaks	Peaks	NNP
10_1101-2020_06_17_156679	389	2	of	of	IN
10_1101-2020_06_17_156679	389	3	ligand	ligand	NNP
10_1101-2020_06_17_156679	389	4	EDJ	EDJ	NNP
10_1101-2020_06_17_156679	389	5	-	-	HYPH
10_1101-2020_06_17_156679	389	6	MED-495	MED-495	NNP
10_1101-2020_06_17_156679	389	7	c8e7a002	c8e7a002	NNP
10_1101-2020_06_17_156679	389	8	-	-	HYPH
10_1101-2020_06_17_156679	389	9	1	1	NNP
10_1101-2020_06_17_156679	389	10	(	(	-LRB-
10_1101-2020_06_17_156679	389	11	green	green	NN
10_1101-2020_06_17_156679	389	12	)	)	-RRB-
10_1101-2020_06_17_156679	389	13	are	be	VBP
10_1101-2020_06_17_156679	389	14	indicated	indicate	VBN
10_1101-2020_06_17_156679	389	15	by	by	IN
10_1101-2020_06_17_156679	389	16	arrows	arrow	NNS
10_1101-2020_06_17_156679	389	17	;	;	:
10_1101-2020_06_17_156679	389	18	ligand	ligand	NNP
10_1101-2020_06_17_156679	389	19	EDJ	EDJ	NNP
10_1101-2020_06_17_156679	389	20	-	-	HYPH
10_1101-2020_06_17_156679	389	21	MED	MED	NNP
10_1101-2020_06_17_156679	389	22	-	-	HYPH
10_1101-2020_06_17_156679	389	23	e4b030d8	e4b030d8	NNP
10_1101-2020_06_17_156679	389	24	-	-	HYPH
10_1101-2020_06_17_156679	389	25	12	12	NNP
10_1101-2020_06_17_156679	389	26	(	(	-LRB-
10_1101-2020_06_17_156679	389	27	red	red	NNP
10_1101-2020_06_17_156679	389	28	)	)	-RRB-
10_1101-2020_06_17_156679	389	29	produced	produce	VBD
10_1101-2020_06_17_156679	389	30	no	no	DT
10_1101-2020_06_17_156679	389	31	peaks	peak	NNS
10_1101-2020_06_17_156679	389	32	496	496	CD
10_1101-2020_06_17_156679	389	33	in	in	IN
10_1101-2020_06_17_156679	389	34	the	the	DT
10_1101-2020_06_17_156679	389	35	NMR	NMR	NNP
10_1101-2020_06_17_156679	389	36	spectrum	spectrum	NN
10_1101-2020_06_17_156679	389	37	.	.	.
10_1101-2020_06_17_156679	390	1	B	b	NN
10_1101-2020_06_17_156679	390	2	)	)	-RRB-
10_1101-2020_06_17_156679	390	3	Plot	Plot	NNP
10_1101-2020_06_17_156679	390	4	of	of	IN
10_1101-2020_06_17_156679	390	5	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	390	6	values	value	NNS
10_1101-2020_06_17_156679	390	7	from	from	IN
10_1101-2020_06_17_156679	390	8	COVID	COVID	NNP
10_1101-2020_06_17_156679	390	9	Moonshot	Moonshot	NNP
10_1101-2020_06_17_156679	390	10	ligands	ligand	NNS
10_1101-2020_06_17_156679	390	11	assessed	assess	VBN
10_1101-2020_06_17_156679	390	12	by	by	IN
10_1101-2020_06_17_156679	390	13	STD	STD	NNP
10_1101-2020_06_17_156679	390	14	-	-	HYPH
10_1101-2020_06_17_156679	390	15	NMR	NMR	NNP
10_1101-2020_06_17_156679	390	16	497	497	CD
10_1101-2020_06_17_156679	390	17	against	against	IN
10_1101-2020_06_17_156679	390	18	their	-PRON-	PRP$
10_1101-2020_06_17_156679	390	19	IC50	IC50	NNP
10_1101-2020_06_17_156679	390	20	value	value	NN
10_1101-2020_06_17_156679	390	21	estimated	estimate	VBN
10_1101-2020_06_17_156679	390	22	by	by	IN
10_1101-2020_06_17_156679	390	23	RapidFire	RapidFire	NNP
10_1101-2020_06_17_156679	390	24	mass	mass	NN
10_1101-2020_06_17_156679	390	25	spectroscopy	spectroscopy	NN
10_1101-2020_06_17_156679	390	26	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	390	27	assays	assay	NNS
10_1101-2020_06_17_156679	390	28	(	(	-LRB-
10_1101-2020_06_17_156679	390	29	17	17	CD
10_1101-2020_06_17_156679	390	30	)	)	-RRB-
10_1101-2020_06_17_156679	390	31	.	.	.
10_1101-2020_06_17_156679	391	1	Ligands	ligand	NNS
10_1101-2020_06_17_156679	391	2	in	in	IN
10_1101-2020_06_17_156679	391	3	498	498	CD
10_1101-2020_06_17_156679	391	4	.CC	.CC	NFP
10_1101-2020_06_17_156679	391	5	-	-	:
10_1101-2020_06_17_156679	391	6	BY	by	IN
10_1101-2020_06_17_156679	391	7	4.0	4.0	CD
10_1101-2020_06_17_156679	391	8	International	International	NNP
10_1101-2020_06_17_156679	391	9	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	391	10	under	under	IN
10_1101-2020_06_17_156679	391	11	a	a	DT
10_1101-2020_06_17_156679	391	12	(	(	-LRB-
10_1101-2020_06_17_156679	391	13	which	which	WDT
10_1101-2020_06_17_156679	391	14	was	be	VBD
10_1101-2020_06_17_156679	391	15	not	not	RB
10_1101-2020_06_17_156679	391	16	certified	certify	VBN
10_1101-2020_06_17_156679	391	17	by	by	IN
10_1101-2020_06_17_156679	391	18	peer	peer	NN
10_1101-2020_06_17_156679	391	19	review	review	NN
10_1101-2020_06_17_156679	391	20	)	)	-RRB-
10_1101-2020_06_17_156679	391	21	is	be	VBZ
10_1101-2020_06_17_156679	391	22	the	the	DT
10_1101-2020_06_17_156679	391	23	author	author	NN
10_1101-2020_06_17_156679	391	24	/	/	SYM
10_1101-2020_06_17_156679	391	25	funder	funder	NN
10_1101-2020_06_17_156679	391	26	,	,	,
10_1101-2020_06_17_156679	391	27	who	who	WP
10_1101-2020_06_17_156679	391	28	has	have	VBZ
10_1101-2020_06_17_156679	391	29	granted	grant	VBN
10_1101-2020_06_17_156679	391	30	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	391	31	a	a	DT
10_1101-2020_06_17_156679	391	32	license	license	NN
10_1101-2020_06_17_156679	391	33	to	to	TO
10_1101-2020_06_17_156679	391	34	display	display	VB
10_1101-2020_06_17_156679	391	35	the	the	DT
10_1101-2020_06_17_156679	391	36	preprint	preprint	NN
10_1101-2020_06_17_156679	391	37	in	in	IN
10_1101-2020_06_17_156679	391	38	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	391	39	.	.	.
10_1101-2020_06_17_156679	392	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	392	2	is	be	VBZ
10_1101-2020_06_17_156679	392	3	made	make	VBN
10_1101-2020_06_17_156679	392	4	The	the	DT
10_1101-2020_06_17_156679	392	5	copyright	copyright	NN
10_1101-2020_06_17_156679	392	6	holder	holder	NN
10_1101-2020_06_17_156679	392	7	for	for	IN
10_1101-2020_06_17_156679	392	8	this	this	DT
10_1101-2020_06_17_156679	392	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	392	10	version	version	NN
10_1101-2020_06_17_156679	392	11	posted	post	VBD
10_1101-2020_06_17_156679	392	12	January	January	NNP
10_1101-2020_06_17_156679	392	13	6	6	CD
10_1101-2020_06_17_156679	392	14	,	,	,
10_1101-2020_06_17_156679	392	15	2021	2021	CD
10_1101-2020_06_17_156679	392	16	.	.	.
10_1101-2020_06_17_156679	392	17	;	;	:
10_1101-2020_06_17_156679	392	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	392	19	:	:	:
10_1101-2020_06_17_156679	392	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	392	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	392	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	392	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	392	24	18	18	CD
10_1101-2020_06_17_156679	392	25	blue	blue	JJ
10_1101-2020_06_17_156679	392	26	show	show	NN
10_1101-2020_06_17_156679	392	27	weak	weak	JJ
10_1101-2020_06_17_156679	392	28	correlation	correlation	NN
10_1101-2020_06_17_156679	392	29	between	between	IN
10_1101-2020_06_17_156679	392	30	the	the	DT
10_1101-2020_06_17_156679	392	31	two	two	CD
10_1101-2020_06_17_156679	392	32	methods	method	NNS
10_1101-2020_06_17_156679	392	33	(	(	-LRB-
10_1101-2020_06_17_156679	392	34	red	red	JJ
10_1101-2020_06_17_156679	392	35	line	line	NN
10_1101-2020_06_17_156679	392	36	,	,	,
10_1101-2020_06_17_156679	392	37	corresponding	correspond	VBG
10_1101-2020_06_17_156679	392	38	to	to	IN
10_1101-2020_06_17_156679	392	39	an	an	DT
10_1101-2020_06_17_156679	392	40	exponential	exponential	JJ
10_1101-2020_06_17_156679	392	41	499	499	CD
10_1101-2020_06_17_156679	392	42	function	function	NN
10_1101-2020_06_17_156679	392	43	along	along	IN
10_1101-2020_06_17_156679	392	44	the	the	DT
10_1101-2020_06_17_156679	392	45	IC50	IC50	NNP
10_1101-2020_06_17_156679	392	46	dimension	dimension	NN
10_1101-2020_06_17_156679	392	47	)	)	-RRB-
10_1101-2020_06_17_156679	392	48	.	.	.
10_1101-2020_06_17_156679	393	1	Ligands	ligand	NNS
10_1101-2020_06_17_156679	393	2	in	in	IN
10_1101-2020_06_17_156679	393	3	grey	grey	NN
10_1101-2020_06_17_156679	393	4	represent	represent	VBP
10_1101-2020_06_17_156679	393	5	outliers	outlier	NNS
10_1101-2020_06_17_156679	393	6	of	of	IN
10_1101-2020_06_17_156679	393	7	the	the	DT
10_1101-2020_06_17_156679	393	8	STD	STD	NNP
10_1101-2020_06_17_156679	393	9	-	-	HYPH
10_1101-2020_06_17_156679	393	10	NMR	NMR	NNP
10_1101-2020_06_17_156679	393	11	or	or	CC
10_1101-2020_06_17_156679	393	12	enzymatic	enzymatic	JJ
10_1101-2020_06_17_156679	393	13	500	500	CD
10_1101-2020_06_17_156679	393	14	method	method	NN
10_1101-2020_06_17_156679	393	15	as	as	IN
10_1101-2020_06_17_156679	393	16	discussed	discuss	VBN
10_1101-2020_06_17_156679	393	17	in	in	IN
10_1101-2020_06_17_156679	393	18	the	the	DT
10_1101-2020_06_17_156679	393	19	text	text	NN
10_1101-2020_06_17_156679	393	20	.	.	.
10_1101-2020_06_17_156679	394	1	501	501	CD
10_1101-2020_06_17_156679	394	2	502	502	CD
10_1101-2020_06_17_156679	394	3	503	503	CD
10_1101-2020_06_17_156679	394	4	.CC	.CC	:
10_1101-2020_06_17_156679	394	5	-	-	:
10_1101-2020_06_17_156679	394	6	BY	by	IN
10_1101-2020_06_17_156679	394	7	4.0	4.0	CD
10_1101-2020_06_17_156679	394	8	International	International	NNP
10_1101-2020_06_17_156679	394	9	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	394	10	under	under	IN
10_1101-2020_06_17_156679	394	11	a	a	DT
10_1101-2020_06_17_156679	394	12	(	(	-LRB-
10_1101-2020_06_17_156679	394	13	which	which	WDT
10_1101-2020_06_17_156679	394	14	was	be	VBD
10_1101-2020_06_17_156679	394	15	not	not	RB
10_1101-2020_06_17_156679	394	16	certified	certify	VBN
10_1101-2020_06_17_156679	394	17	by	by	IN
10_1101-2020_06_17_156679	394	18	peer	peer	NN
10_1101-2020_06_17_156679	394	19	review	review	NN
10_1101-2020_06_17_156679	394	20	)	)	-RRB-
10_1101-2020_06_17_156679	394	21	is	be	VBZ
10_1101-2020_06_17_156679	394	22	the	the	DT
10_1101-2020_06_17_156679	394	23	author	author	NN
10_1101-2020_06_17_156679	394	24	/	/	SYM
10_1101-2020_06_17_156679	394	25	funder	funder	NN
10_1101-2020_06_17_156679	394	26	,	,	,
10_1101-2020_06_17_156679	394	27	who	who	WP
10_1101-2020_06_17_156679	394	28	has	have	VBZ
10_1101-2020_06_17_156679	394	29	granted	grant	VBN
10_1101-2020_06_17_156679	394	30	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	394	31	a	a	DT
10_1101-2020_06_17_156679	394	32	license	license	NN
10_1101-2020_06_17_156679	394	33	to	to	TO
10_1101-2020_06_17_156679	394	34	display	display	VB
10_1101-2020_06_17_156679	394	35	the	the	DT
10_1101-2020_06_17_156679	394	36	preprint	preprint	NN
10_1101-2020_06_17_156679	394	37	in	in	IN
10_1101-2020_06_17_156679	394	38	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	394	39	.	.	.
10_1101-2020_06_17_156679	395	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	395	2	is	be	VBZ
10_1101-2020_06_17_156679	395	3	made	make	VBN
10_1101-2020_06_17_156679	395	4	The	the	DT
10_1101-2020_06_17_156679	395	5	copyright	copyright	NN
10_1101-2020_06_17_156679	395	6	holder	holder	NN
10_1101-2020_06_17_156679	395	7	for	for	IN
10_1101-2020_06_17_156679	395	8	this	this	DT
10_1101-2020_06_17_156679	395	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	395	10	version	version	NN
10_1101-2020_06_17_156679	395	11	posted	post	VBD
10_1101-2020_06_17_156679	395	12	January	January	NNP
10_1101-2020_06_17_156679	395	13	6	6	CD
10_1101-2020_06_17_156679	395	14	,	,	,
10_1101-2020_06_17_156679	395	15	2021	2021	CD
10_1101-2020_06_17_156679	395	16	.	.	.
10_1101-2020_06_17_156679	395	17	;	;	:
10_1101-2020_06_17_156679	395	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	395	19	:	:	:
10_1101-2020_06_17_156679	395	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	395	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	395	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	395	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	395	24	10	10	CD
10_1101-2020_06_17_156679	395	25	8	8	CD
10_1101-2020_06_17_156679	395	26	6	6	CD
10_1101-2020_06_17_156679	395	27	4	4	CD
10_1101-2020_06_17_156679	395	28	2	2	CD
10_1101-2020_06_17_156679	395	29	0	0	CD
10_1101-2020_06_17_156679	395	30	x0434	x0434	NNP
10_1101-2020_06_17_156679	395	31	H2O	h2o	CD
10_1101-2020_06_17_156679	395	32	DMSO	DMSO	NNP
10_1101-2020_06_17_156679	395	33	Reference	Reference	NNP
10_1101-2020_06_17_156679	395	34	STD	STD	NNP
10_1101-2020_06_17_156679	395	35	(	(	-LRB-
10_1101-2020_06_17_156679	395	36	+	+	CC
10_1101-2020_06_17_156679	395	37	Mpro	Mpro	NNP
10_1101-2020_06_17_156679	395	38	)	)	-RRB-
10_1101-2020_06_17_156679	395	39	STD	STD	NNP
10_1101-2020_06_17_156679	395	40	(	(	-LRB-
10_1101-2020_06_17_156679	395	41	-Mpro	-Mpro	NNP
10_1101-2020_06_17_156679	395	42	)	)	-RRB-
10_1101-2020_06_17_156679	395	43	B	b	NN
10_1101-2020_06_17_156679	395	44	2	2	CD
10_1101-2020_06_17_156679	395	45	0	0	CD
10_1101-2020_06_17_156679	395	46	STD	STD	NNP
10_1101-2020_06_17_156679	395	47	irradiation	irradiation	NN
10_1101-2020_06_17_156679	395	48	A	a	DT
10_1101-2020_06_17_156679	395	49	2	2	CD
10_1101-2020_06_17_156679	395	50	0	0	CD
10_1101-2020_06_17_156679	395	51	25	25	CD
10_1101-2020_06_17_156679	395	52	oC	oc	CD
10_1101-2020_06_17_156679	395	53	10	10	CD
10_1101-2020_06_17_156679	395	54	oC	oC	NNP
10_1101-2020_06_17_156679	395	55	δ	δ	NN
10_1101-2020_06_17_156679	395	56	1H	1H	NNP
10_1101-2020_06_17_156679	395	57	(	(	-LRB-
10_1101-2020_06_17_156679	395	58	ppm	ppm	NNP
10_1101-2020_06_17_156679	395	59	)	)	-RRB-
10_1101-2020_06_17_156679	395	60	N	N	NNP
10_1101-2020_06_17_156679	395	61	NH	NH	NNP
10_1101-2020_06_17_156679	395	62	NH	NH	NNP
10_1101-2020_06_17_156679	395	63	O	o	NN
10_1101-2020_06_17_156679	395	64	x0434	x0434	NN
10_1101-2020_06_17_156679	395	65	1	1	CD
10_1101-2020_06_17_156679	395	66	δ	δ	NN
10_1101-2020_06_17_156679	395	67	1H	1H	NNP
10_1101-2020_06_17_156679	395	68	(	(	-LRB-
10_1101-2020_06_17_156679	395	69	ppm	ppm	NNP
10_1101-2020_06_17_156679	395	70	)	)	-RRB-
10_1101-2020_06_17_156679	395	71	δ	δ	NN
10_1101-2020_06_17_156679	395	72	1H	1H	NNP
10_1101-2020_06_17_156679	395	73	(	(	-LRB-
10_1101-2020_06_17_156679	395	74	ppm	ppm	NNP
10_1101-2020_06_17_156679	395	75	)	)	-RRB-
10_1101-2020_06_17_156679	395	76	2	2	CD
10_1101-2020_06_17_156679	395	77	3	3	CD
10_1101-2020_06_17_156679	395	78	4	4	CD
10_1101-2020_06_17_156679	395	79	1	1	CD
10_1101-2020_06_17_156679	395	80	2	2	CD
10_1101-2020_06_17_156679	395	81	3	3	CD
10_1101-2020_06_17_156679	395	82	4	4	CD
10_1101-2020_06_17_156679	395	83	5	5	CD
10_1101-2020_06_17_156679	395	84	5	5	CD
10_1101-2020_06_17_156679	395	85	.CC	.cc	CD
10_1101-2020_06_17_156679	395	86	-	-	:
10_1101-2020_06_17_156679	395	87	BY	by	IN
10_1101-2020_06_17_156679	395	88	4.0	4.0	CD
10_1101-2020_06_17_156679	395	89	International	International	NNP
10_1101-2020_06_17_156679	395	90	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	395	91	under	under	IN
10_1101-2020_06_17_156679	395	92	a	a	DT
10_1101-2020_06_17_156679	395	93	(	(	-LRB-
10_1101-2020_06_17_156679	395	94	which	which	WDT
10_1101-2020_06_17_156679	395	95	was	be	VBD
10_1101-2020_06_17_156679	395	96	not	not	RB
10_1101-2020_06_17_156679	395	97	certified	certify	VBN
10_1101-2020_06_17_156679	395	98	by	by	IN
10_1101-2020_06_17_156679	395	99	peer	peer	NN
10_1101-2020_06_17_156679	395	100	review	review	NN
10_1101-2020_06_17_156679	395	101	)	)	-RRB-
10_1101-2020_06_17_156679	395	102	is	be	VBZ
10_1101-2020_06_17_156679	395	103	the	the	DT
10_1101-2020_06_17_156679	395	104	author	author	NN
10_1101-2020_06_17_156679	395	105	/	/	SYM
10_1101-2020_06_17_156679	395	106	funder	funder	NN
10_1101-2020_06_17_156679	395	107	,	,	,
10_1101-2020_06_17_156679	395	108	who	who	WP
10_1101-2020_06_17_156679	395	109	has	have	VBZ
10_1101-2020_06_17_156679	395	110	granted	grant	VBN
10_1101-2020_06_17_156679	395	111	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	395	112	a	a	DT
10_1101-2020_06_17_156679	395	113	license	license	NN
10_1101-2020_06_17_156679	395	114	to	to	TO
10_1101-2020_06_17_156679	395	115	display	display	VB
10_1101-2020_06_17_156679	395	116	the	the	DT
10_1101-2020_06_17_156679	395	117	preprint	preprint	NN
10_1101-2020_06_17_156679	395	118	in	in	IN
10_1101-2020_06_17_156679	395	119	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	395	120	.	.	.
10_1101-2020_06_17_156679	396	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	396	2	is	be	VBZ
10_1101-2020_06_17_156679	396	3	made	make	VBN
10_1101-2020_06_17_156679	396	4	The	the	DT
10_1101-2020_06_17_156679	396	5	copyright	copyright	NN
10_1101-2020_06_17_156679	396	6	holder	holder	NN
10_1101-2020_06_17_156679	396	7	for	for	IN
10_1101-2020_06_17_156679	396	8	this	this	DT
10_1101-2020_06_17_156679	396	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	396	10	version	version	NN
10_1101-2020_06_17_156679	396	11	posted	post	VBD
10_1101-2020_06_17_156679	396	12	January	January	NNP
10_1101-2020_06_17_156679	396	13	6	6	CD
10_1101-2020_06_17_156679	396	14	,	,	,
10_1101-2020_06_17_156679	396	15	2021	2021	CD
10_1101-2020_06_17_156679	396	16	.	.	.
10_1101-2020_06_17_156679	396	17	;	;	:
10_1101-2020_06_17_156679	396	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	396	19	:	:	:
10_1101-2020_06_17_156679	396	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	396	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	396	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	396	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD
10_1101-2020_06_17_156679	396	24	0	0	CD
10_1101-2020_06_17_156679	396	25	10	10	CD
10_1101-2020_06_17_156679	396	26	20	20	CD
10_1101-2020_06_17_156679	396	27	30	30	CD
10_1101-2020_06_17_156679	396	28	40	40	CD
10_1101-2020_06_17_156679	396	29	50	50	CD
10_1101-2020_06_17_156679	396	30	60	60	CD
10_1101-2020_06_17_156679	396	31	x0434	x0434	NNP
10_1101-2020_06_17_156679	396	32	x0195	x0195	NNP
10_1101-2020_06_17_156679	396	33	x0540	x0540	NNP
10_1101-2020_06_17_156679	396	34	x0426	x0426	NNP
10_1101-2020_06_17_156679	396	35	x0305	x0305	NNP
10_1101-2020_06_17_156679	396	36	x0072	x0072	NNP
10_1101-2020_06_17_156679	396	37	x0161	x0161	NNP
10_1101-2020_06_17_156679	396	38	x0107	x0107	NNP
10_1101-2020_06_17_156679	396	39	x1249	x1249	NNP
10_1101-2020_06_17_156679	396	40	x0395	x0395	NNP
10_1101-2020_06_17_156679	396	41	x0354	x0354	NNP
10_1101-2020_06_17_156679	396	42	x0387	x0387	NNP
10_1101-2020_06_17_156679	396	43	x0397	x0397	NNP
10_1101-2020_06_17_156679	396	44	x1187	x1187	NNP
10_1101-2020_06_17_156679	396	45	x0390	x0390	NNP
10_1101-2020_06_17_156679	396	46	x0194	x0194	NNP
10_1101-2020_06_17_156679	396	47	X	X	NNP
10_1101-2020_06_17_156679	396	48	1086	1086	CD
10_1101-2020_06_17_156679	396	49	X	x	NN
10_1101-2020_06_17_156679	396	50	1237	1237	CD
10_1101-2020_06_17_156679	396	51	X	X	NNP
10_1101-2020_06_17_156679	396	52	0350	0350	CD
10_1101-2020_06_17_156679	396	53	x1226	x1226	NNP
10_1101-2020_06_17_156679	396	54	X	X	NNP
10_1101-2020_06_17_156679	396	55	1235	1235	CD
10_1101-2020_06_17_156679	396	56	X	x	NN
10_1101-2020_06_17_156679	396	57	0669	0669	CD
10_1101-2020_06_17_156679	396	58	x0398	x0398	NNP
10_1101-2020_06_17_156679	396	59	x0478	x0478	NNP
10_1101-2020_06_17_156679	396	60	X	X	NNP
10_1101-2020_06_17_156679	396	61	1119	1119	CD
10_1101-2020_06_17_156679	396	62	X	x	NN
10_1101-2020_06_17_156679	396	63	0177	0177	CD
10_1101-2020_06_17_156679	396	64	X	x	NN
10_1101-2020_06_17_156679	396	65	0376	0376	CD
10_1101-2020_06_17_156679	396	66	X	x	NN
10_1101-2020_06_17_156679	396	67	1132	1132	CD
10_1101-2020_06_17_156679	396	68	X	x	NN
10_1101-2020_06_17_156679	396	69	0499	0499	CD
10_1101-2020_06_17_156679	396	70	X	x	NN
10_1101-2020_06_17_156679	396	71	1101	1101	CD
10_1101-2020_06_17_156679	396	72	X	X	NNP
10_1101-2020_06_17_156679	396	73	1163	1163	CD
10_1101-2020_06_17_156679	396	74	x0464	x0464	NNP
10_1101-2020_06_17_156679	396	75	X	X	NNP
10_1101-2020_06_17_156679	396	76	0336	0336	CD
10_1101-2020_06_17_156679	396	77	X	x	NN
10_1101-2020_06_17_156679	396	78	0165	0165	CD
10_1101-2020_06_17_156679	396	79	x0425	x0425	NNP
10_1101-2020_06_17_156679	396	80	S	S	NNP
10_1101-2020_06_17_156679	396	81	TD	TD	NNP
10_1101-2020_06_17_156679	396	82	ra	ra	NNP
10_1101-2020_06_17_156679	396	83	tio	tio	NN
10_1101-2020_06_17_156679	396	84	(	(	-LRB-
10_1101-2020_06_17_156679	396	85	x	x	DT
10_1101-2020_06_17_156679	396	86	1	1	CD
10_1101-2020_06_17_156679	396	87	0-	0-	SYM
10_1101-2020_06_17_156679	396	88	3	3	CD
10_1101-2020_06_17_156679	396	89	)	)	-RRB-
10_1101-2020_06_17_156679	396	90	Ligand	Ligand	NNP
10_1101-2020_06_17_156679	396	91	fragments	fragment	NNS
10_1101-2020_06_17_156679	396	92	x0305	x0305	NNP
10_1101-2020_06_17_156679	396	93	x0387	x0387	NNP
10_1101-2020_06_17_156679	396	94	x0434	x0434	NNP
10_1101-2020_06_17_156679	396	95	[	[	-LRB-
10_1101-2020_06_17_156679	396	96	ppm	ppm	NNP
10_1101-2020_06_17_156679	396	97	]	]	-RRB-
10_1101-2020_06_17_156679	396	98	8.5	8.5	CD
10_1101-2020_06_17_156679	396	99	8.0	8.0	CD
10_1101-2020_06_17_156679	396	100	7.5	7.5	CD
10_1101-2020_06_17_156679	396	101	7.0	7.0	CD
10_1101-2020_06_17_156679	396	102	6.5	6.5	CD
10_1101-2020_06_17_156679	396	103	δ	δ	NN
10_1101-2020_06_17_156679	396	104	1H	1H	NNP
10_1101-2020_06_17_156679	396	105	(	(	-LRB-
10_1101-2020_06_17_156679	396	106	ppm	ppm	NN
10_1101-2020_06_17_156679	396	107	)	)	-RRB-
10_1101-2020_06_17_156679	396	108	B	b	NN
10_1101-2020_06_17_156679	396	109	A	a	DT
10_1101-2020_06_17_156679	396	110	[	[	-LRB-
10_1101-2020_06_17_156679	396	111	ppm	ppm	NN
10_1101-2020_06_17_156679	396	112	]	]	-RRB-
10_1101-2020_06_17_156679	396	113	8.0	8.0	CD
10_1101-2020_06_17_156679	396	114	7.5	7.5	CD
10_1101-2020_06_17_156679	396	115	7.0	7.0	CD
10_1101-2020_06_17_156679	396	116	6.5	6.5	CD
10_1101-2020_06_17_156679	396	117	6.0	6.0	CD
10_1101-2020_06_17_156679	396	118	5.5	5.5	CD
10_1101-2020_06_17_156679	396	119	x0305	x0305	CD
10_1101-2020_06_17_156679	396	120	x0376	x0376	NNP
10_1101-2020_06_17_156679	396	121	x0540	x0540	NNP
10_1101-2020_06_17_156679	396	122	C	C	NNP
10_1101-2020_06_17_156679	396	123	.CC	.CC	,
10_1101-2020_06_17_156679	396	124	-	-	:
10_1101-2020_06_17_156679	396	125	BY	by	IN
10_1101-2020_06_17_156679	396	126	4.0	4.0	CD
10_1101-2020_06_17_156679	396	127	International	International	NNP
10_1101-2020_06_17_156679	396	128	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	396	129	under	under	IN
10_1101-2020_06_17_156679	396	130	a	a	DT
10_1101-2020_06_17_156679	396	131	(	(	-LRB-
10_1101-2020_06_17_156679	396	132	which	which	WDT
10_1101-2020_06_17_156679	396	133	was	be	VBD
10_1101-2020_06_17_156679	396	134	not	not	RB
10_1101-2020_06_17_156679	396	135	certified	certify	VBN
10_1101-2020_06_17_156679	396	136	by	by	IN
10_1101-2020_06_17_156679	396	137	peer	peer	NN
10_1101-2020_06_17_156679	396	138	review	review	NN
10_1101-2020_06_17_156679	396	139	)	)	-RRB-
10_1101-2020_06_17_156679	396	140	is	be	VBZ
10_1101-2020_06_17_156679	396	141	the	the	DT
10_1101-2020_06_17_156679	396	142	author	author	NN
10_1101-2020_06_17_156679	396	143	/	/	SYM
10_1101-2020_06_17_156679	396	144	funder	funder	NN
10_1101-2020_06_17_156679	396	145	,	,	,
10_1101-2020_06_17_156679	396	146	who	who	WP
10_1101-2020_06_17_156679	396	147	has	have	VBZ
10_1101-2020_06_17_156679	396	148	granted	grant	VBN
10_1101-2020_06_17_156679	396	149	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	396	150	a	a	DT
10_1101-2020_06_17_156679	396	151	license	license	NN
10_1101-2020_06_17_156679	396	152	to	to	TO
10_1101-2020_06_17_156679	396	153	display	display	VB
10_1101-2020_06_17_156679	396	154	the	the	DT
10_1101-2020_06_17_156679	396	155	preprint	preprint	NN
10_1101-2020_06_17_156679	396	156	in	in	IN
10_1101-2020_06_17_156679	396	157	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	396	158	.	.	.
10_1101-2020_06_17_156679	397	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	397	2	is	be	VBZ
10_1101-2020_06_17_156679	397	3	made	make	VBN
10_1101-2020_06_17_156679	397	4	The	the	DT
10_1101-2020_06_17_156679	397	5	copyright	copyright	NN
10_1101-2020_06_17_156679	397	6	holder	holder	NN
10_1101-2020_06_17_156679	397	7	for	for	IN
10_1101-2020_06_17_156679	397	8	this	this	DT
10_1101-2020_06_17_156679	397	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	397	10	version	version	NN
10_1101-2020_06_17_156679	397	11	posted	post	VBD
10_1101-2020_06_17_156679	397	12	January	January	NNP
10_1101-2020_06_17_156679	397	13	6	6	CD
10_1101-2020_06_17_156679	397	14	,	,	,
10_1101-2020_06_17_156679	397	15	2021	2021	CD
10_1101-2020_06_17_156679	397	16	.	.	.
10_1101-2020_06_17_156679	397	17	;	;	:
10_1101-2020_06_17_156679	397	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	397	19	:	:	:
10_1101-2020_06_17_156679	397	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	397	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	397	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	PRP$
10_1101-2020_06_17_156679	397	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	-LRB-
10_1101-2020_06_17_156679	397	24	[	[	-LRB-
10_1101-2020_06_17_156679	397	25	ppm	ppm	NNP
10_1101-2020_06_17_156679	397	26	]	]	-RRB-
10_1101-2020_06_17_156679	397	27	8.0	8.0	CD
10_1101-2020_06_17_156679	397	28	7.5	7.5	CD
10_1101-2020_06_17_156679	397	29	7.0	7.0	CD
10_1101-2020_06_17_156679	397	30	6.5	6.5	CD
10_1101-2020_06_17_156679	397	31	6.0	6.0	CD
10_1101-2020_06_17_156679	397	32	RAL	RAL	NNP
10_1101-2020_06_17_156679	397	33	-	-	HYPH
10_1101-2020_06_17_156679	397	34	THA-6b94ceba-1	THA-6b94ceba-1	NNP
10_1101-2020_06_17_156679	397	35	LOR	LOR	NNP
10_1101-2020_06_17_156679	397	36	-	-	HYPH
10_1101-2020_06_17_156679	397	37	NOR	NOR	NNP
10_1101-2020_06_17_156679	397	38	-	-	HYPH
10_1101-2020_06_17_156679	397	39	c954e7ad-2	c954e7ad-2	NNP
10_1101-2020_06_17_156679	397	40	EDJ	EDJ	NNP
10_1101-2020_06_17_156679	397	41	-	-	HYPH
10_1101-2020_06_17_156679	397	42	MED	MED	NNP
10_1101-2020_06_17_156679	397	43	-	-	HYPH
10_1101-2020_06_17_156679	397	44	c8e7a002	c8e7a002	NNP
10_1101-2020_06_17_156679	397	45	-	-	HYPH
10_1101-2020_06_17_156679	397	46	1	1	CD
10_1101-2020_06_17_156679	397	47	EDJ	EDJ	NNP
10_1101-2020_06_17_156679	397	48	-	-	HYPH
10_1101-2020_06_17_156679	397	49	MED	MED	NNP
10_1101-2020_06_17_156679	397	50	-	-	HYPH
10_1101-2020_06_17_156679	397	51	e4b030d8	e4b030d8	NNP
10_1101-2020_06_17_156679	397	52	-	-	HYPH
10_1101-2020_06_17_156679	397	53	12	12	CD
10_1101-2020_06_17_156679	397	54	A	a	NN
10_1101-2020_06_17_156679	397	55	δ	δ	NN
10_1101-2020_06_17_156679	397	56	1H	1h	NN
10_1101-2020_06_17_156679	397	57	(	(	-LRB-
10_1101-2020_06_17_156679	397	58	ppm	ppm	NNP
10_1101-2020_06_17_156679	397	59	)	)	-RRB-
10_1101-2020_06_17_156679	397	60	0.01	0.01	CD
10_1101-2020_06_17_156679	397	61	0.1	0.1	CD
10_1101-2020_06_17_156679	397	62	1	1	CD
10_1101-2020_06_17_156679	397	63	10	10	CD
10_1101-2020_06_17_156679	397	64	100	100	CD
10_1101-2020_06_17_156679	397	65	0	0	CD
10_1101-2020_06_17_156679	397	66	100	100	CD
10_1101-2020_06_17_156679	397	67	200	200	CD
10_1101-2020_06_17_156679	397	68	300	300	CD
10_1101-2020_06_17_156679	397	69	400	400	CD
10_1101-2020_06_17_156679	397	70	500	500	CD
10_1101-2020_06_17_156679	397	71	R	r	NN
10_1101-2020_06_17_156679	397	72	ap	ap	UH
10_1101-2020_06_17_156679	397	73	i	-PRON-	PRP
10_1101-2020_06_17_156679	397	74	d	d	FW
10_1101-2020_06_17_156679	397	75	Fi	Fi	NNP
10_1101-2020_06_17_156679	397	76	re	re	IN
10_1101-2020_06_17_156679	397	77	IC	IC	NNP
10_1101-2020_06_17_156679	397	78	50	50	CD
10_1101-2020_06_17_156679	397	79	(	(	-LRB-
10_1101-2020_06_17_156679	397	80	µ	µ	NN
10_1101-2020_06_17_156679	397	81	M	M	NNP
10_1101-2020_06_17_156679	397	82	)	)	-RRB-
10_1101-2020_06_17_156679	397	83	STDratio	STDratio	NNP
10_1101-2020_06_17_156679	397	84	(	(	-LRB-
10_1101-2020_06_17_156679	397	85	x	x	SYM
10_1101-2020_06_17_156679	397	86	10	10	CD
10_1101-2020_06_17_156679	397	87	-	-	HYPH
10_1101-2020_06_17_156679	397	88	3)B	3)B	NNP
10_1101-2020_06_17_156679	397	89	R2=30	R2=30	NNP
10_1101-2020_06_17_156679	397	90	%	%	NN
10_1101-2020_06_17_156679	397	91	.CC	.CC	,
10_1101-2020_06_17_156679	397	92	-	-	:
10_1101-2020_06_17_156679	397	93	BY	by	IN
10_1101-2020_06_17_156679	397	94	4.0	4.0	CD
10_1101-2020_06_17_156679	397	95	International	International	NNP
10_1101-2020_06_17_156679	397	96	licenseavailable	licenseavailable	NN
10_1101-2020_06_17_156679	397	97	under	under	IN
10_1101-2020_06_17_156679	397	98	a	a	DT
10_1101-2020_06_17_156679	397	99	(	(	-LRB-
10_1101-2020_06_17_156679	397	100	which	which	WDT
10_1101-2020_06_17_156679	397	101	was	be	VBD
10_1101-2020_06_17_156679	397	102	not	not	RB
10_1101-2020_06_17_156679	397	103	certified	certify	VBN
10_1101-2020_06_17_156679	397	104	by	by	IN
10_1101-2020_06_17_156679	397	105	peer	peer	NN
10_1101-2020_06_17_156679	397	106	review	review	NN
10_1101-2020_06_17_156679	397	107	)	)	-RRB-
10_1101-2020_06_17_156679	397	108	is	be	VBZ
10_1101-2020_06_17_156679	397	109	the	the	DT
10_1101-2020_06_17_156679	397	110	author	author	NN
10_1101-2020_06_17_156679	397	111	/	/	SYM
10_1101-2020_06_17_156679	397	112	funder	funder	NN
10_1101-2020_06_17_156679	397	113	,	,	,
10_1101-2020_06_17_156679	397	114	who	who	WP
10_1101-2020_06_17_156679	397	115	has	have	VBZ
10_1101-2020_06_17_156679	397	116	granted	grant	VBN
10_1101-2020_06_17_156679	397	117	bioRxiv	biorxiv	IN
10_1101-2020_06_17_156679	397	118	a	a	DT
10_1101-2020_06_17_156679	397	119	license	license	NN
10_1101-2020_06_17_156679	397	120	to	to	TO
10_1101-2020_06_17_156679	397	121	display	display	VB
10_1101-2020_06_17_156679	397	122	the	the	DT
10_1101-2020_06_17_156679	397	123	preprint	preprint	NN
10_1101-2020_06_17_156679	397	124	in	in	IN
10_1101-2020_06_17_156679	397	125	perpetuity	perpetuity	NN
10_1101-2020_06_17_156679	397	126	.	.	.
10_1101-2020_06_17_156679	398	1	It	-PRON-	PRP
10_1101-2020_06_17_156679	398	2	is	be	VBZ
10_1101-2020_06_17_156679	398	3	made	make	VBN
10_1101-2020_06_17_156679	398	4	The	the	DT
10_1101-2020_06_17_156679	398	5	copyright	copyright	NN
10_1101-2020_06_17_156679	398	6	holder	holder	NN
10_1101-2020_06_17_156679	398	7	for	for	IN
10_1101-2020_06_17_156679	398	8	this	this	DT
10_1101-2020_06_17_156679	398	9	preprintthis	preprintthis	NN
10_1101-2020_06_17_156679	398	10	version	version	NN
10_1101-2020_06_17_156679	398	11	posted	post	VBD
10_1101-2020_06_17_156679	398	12	January	January	NNP
10_1101-2020_06_17_156679	398	13	6	6	CD
10_1101-2020_06_17_156679	398	14	,	,	,
10_1101-2020_06_17_156679	398	15	2021	2021	CD
10_1101-2020_06_17_156679	398	16	.	.	.
10_1101-2020_06_17_156679	398	17	;	;	:
10_1101-2020_06_17_156679	398	18	https://doi.org/10.1101/2020.06.17.156679doi	https://doi.org/10.1101/2020.06.17.156679doi	ADD
10_1101-2020_06_17_156679	398	19	:	:	:
10_1101-2020_06_17_156679	398	20	bioRxiv	biorxiv	VB
10_1101-2020_06_17_156679	398	21	preprint	preprint	JJ
10_1101-2020_06_17_156679	398	22	https://doi.org/10.1101/2020.06.17.156679	https://doi.org/10.1101/2020.06.17.156679	ADD
10_1101-2020_06_17_156679	398	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	ADD