id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2021_01_08_425379	Wilmes, Stephan	Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders	2021	75	.pdf	application/pdf	36633	7715	76	Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders STAT1/3 effector activation to an unbiased and quantitative multi-omics approach: phosphoproteomics after early cytokine stimulation, kinetics of transcriptomic changes and alteration action between sustained pSTAT1 and IRF1 expression to drive the induction of an interferonlike gene signature that profoundly shaped the T-cell proteome. IL-27 induces a more sustained STAT1 activation than HypIL-6 in human Th-1 cells little effect on STAT1 activation kinetics when compared to RPE1 wild type cells, suggesting Our data suggest that STAT molecules compete for binding to a limited number of phosphoTyr motifs in the intracellular domains of cytokine receptors. immune cells differ in their expression of cytokine receptors and STATs, we investigated levels STAT1 protein levels in SLE patients modify HypIL-6 and IL-27 signaling responses STAT1 expression could significantly change cytokine-induced cellular responses by HypIL-6 	./cache/10_1101-2021_01_08_425379.pdf	./txt/10_1101-2021_01_08_425379.txt