id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2021_01_03_425159	Berntsson, Elina	6-gingerol interferes with amyloid-beta (Aβ) peptide aggregation	2021	16	.pdf	application/pdf	5880	569	65	6-gingerol interferes with amyloid-beta (Aβ) peptide aggregation 6-gingerol interferes with amyloid-beta (Aβ) peptide aggregation Key Words: Alzheimer's disease; Amyloid aggregation; Neurodegeneration; Ginger; gingerols and Aβ peptides have not been studied at the molecular level. To monitor the effect of 6-gingerol on Aβ40 aggregation kinetics, 15 µM control sample without 6-gingerol but containing 2% DMSO was prepared. the samples to aggregate into mature fibrils that could be observed with AFM imaging gingerol, has minor effects on the aggregation kinetics, i.e. by slightly increasing the With 6-gingerol, some additions produce aggregation kinetics µM 6-gingerol appears to speed up the aggregation (τlag = 0.5 h; τ½ = 1.7 h). gingerol has no systematic effect on Aβ40 aggregation or amyloid formation. sample with 300 µM of 6-gingerol and 2% DMSO does however display a different interactions between 6-gingerol and the monomeric Aβ40 peptide. Alzheimer peptides aggregate Biophysical studies of the amyloid beta-peptide: interactions with metal 	./cache/10_1101-2021_01_03_425159.pdf	./txt/10_1101-2021_01_03_425159.txt