id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
10_1101-2020_12_29_424482	Sauer, Maximilian M.	Structural basis for broad coronavirus neutralization	2021	40	.pdf	application/pdf	15457	1555	68	B6 cross-reactivity with β-coronaviruses from three lineages along with proof-ofconcept for antibody-mediated broad coronavirus neutralization elicited through (mAbs) with potent neutralizing activity were identified against the SARS-CoV-2, SARSCoV and MERS-CoV RBDs and shown to protect against viral challenge in vivo (Alsoussi Crystal structures of B6 in complex with MERS-CoV S, SARSCoV/SARS-CoV-2 S, OC43 S and HKU4 S stem helix peptides combined with binding conformational changes leading to membrane fusion and identify a key target for nextgeneration structure-guided design of a pan-coronavirus vaccine. (A-B) Molecular surface representation of a composite model of the B6-bound MERSCoV S cryoEM structure and of the B6-bound MERS-CoV S stem helix peptide crystal docking the crystal structure of B6 bound to the MERS-CoV stem helix in the cryoEM Comparison of the B6-bound structures of MERS-CoV, HKU4, SARS-CoV/SARSCoV-2 and OC43 S stem helix peptides explains the broad mAb cross-reactivity with βclassification of neutralizing antibodies against the SARS-CoV-2 spike receptor-binding domain 	./cache/10_1101-2020_12_29_424482.pdf	./txt/10_1101-2020_12_29_424482.txt