id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_gml5cul66bbf3b7omxfxjyfjza	Christopher Stephen Thom	Tropomyosin 1 genetically constrains in vitro hematopoiesis	2020	16	.pdf	application/pdf	12296	1411	58	Background: Identifying causal variants and genes from human genetic studies of hematopoietic traits is important performed computational modeling using available genome-wide association datasets for platelet and red blood b To generate a penalized regression model, 580 platelet trait GWAS SNPs [6] and matched control c Penalized regression (LASSO [23]) analysis identified 38 chromatin features from the indicated cell types that best discriminated GWAS SNPs, Hence, our results suggested that chromatin marks associated with active gene regulatory regions were enriched in platelet trait GWAS loci. Platelet and hematopoiesis pathways [30] identified by the highest-scoring (top 1%) SNPs genome-wide for the indicated models, excluding First, rs342293 is a GWAS SNP [5] that regulates PIK3CG gene expression [12] and lies within accessible chromatin in hematopoietic progenitor cell types [53] Penalized regression-based fine-mapping identifies eQTLs in established platelet and/or red cell trait GWAS loci that overlie GATA binding	./cache/work_gml5cul66bbf3b7omxfxjyfjza.pdf	./txt/work_gml5cul66bbf3b7omxfxjyfjza.txt