id author title date pages extension mime words sentences flesch summary cache txt work_kywlvvxt5vcrfohi2hci3bts4a Friedrich C. Luft Sleeping Beauty jumps to new heights 2010 3 .pdf application/pdf 2809 410 58 segments of DNA are sometimes called "jumping genes". Some transposons require a specific sequence as their target site; others Sleeping Beauty's DNA sequence had mutated in fish genomes to the point where the transposon Sleeping Beauty transposase binds to the inverted repeats of DNA-transposon system from vertebrates, to perform insertional mutagenesis, to conduct genetic transformation, and mice harboring the Sleeping Beauty transposon. transposase cuts the transposon DNA away from the flanking "donor" color on the basis of a somatic "jumping gene", namely a transposon. Sleeping Beauty transposon to act as a somatic insertional The authors first constructed an albumin promoterdriven Sleeping Beauty transposase with a wild-type rat expression of the livers in their sickle cell anemia mice with reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, 7. Ivics Z, Izsvák Z (2006) Transposons for gene therapy! integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. ./cache/work_kywlvvxt5vcrfohi2hci3bts4a.pdf ./txt/work_kywlvvxt5vcrfohi2hci3bts4a.txt