id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_5rfc7iayvjawffvdn3fuymeasa	K. M. Mann	Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma	2012	8	.pdf	application/pdf	8578	1175	58	a large number of tumors is required to fully capture the molecular heterogeneity of the disease and identify the specific mutations and signaling pathways that drive disease progression. CCGs. To identify genes that contribute to pancreatic tumor development in oncogenic KrasG12D mice, we PCR-amplified and Genes listed in red are mutated in human pancreatic cancer. Encyclopedia of Genes and Genomes (KEGG) were also frequently mutated in SB-induced pancreatic cancers. data indicate that the gCIS method identifies additional candidate cancer genes important for pancreatic adenocarcinoma in We then interrogated a tissue microarray comprised of threereplicate 1-mM cores from 150 patients with pancreatic adenocarcinoma (40) for levels of protein encoded by frequently mutated CCGs found in enriched signaling pathways. mutation status of the 136 GKC CCGs in human pancreatic cancer Mutations in this tumor suppressor gene have not been identified in pancreatic cancer, although the chromosomal region in which it lies on 10q23 does	./cache/work_5rfc7iayvjawffvdn3fuymeasa.pdf	./txt/work_5rfc7iayvjawffvdn3fuymeasa.txt