The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1161/ATVBAHA.112.245480 Corpus ID: 365608The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish @article{Horenstein2013TheAG, title={The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish}, author={R. Horenstein and B. Mitchell and W. Post and D. L{\"u}tjohann and K. von Bergmann and K. Ryan and M. Terrin and A. Shuldiner and N. Steinle}, journal={Arteriosclerosis, Thrombosis, and Vascular Biology}, year={2013}, volume={33}, pages={413–419} } R. Horenstein, B. Mitchell, +6 authors N. Steinle Published 2013 Biology, Medicine Arteriosclerosis, Thrombosis, and Vascular Biology Objective—To determine whether long-term exposure to moderate elevations in plasma plant sterol levels increases risk for atherosclerosis. Methods and Results—In Old Order Amish participants aged 18 to 85 years, with (n=110) and without (n=181) 1 copy of the ABCG8 G574R variant, we compared mean plasma levels of plant sterols and cholesterol precursors and carotid intima-media wall thickness. Carriers of a single 574R allele had increased plant sterol levels (eg, 35%–37% higher plasma levels of… Expand View on Wolters Kluwer ahajournals.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 21 CitationsBackground Citations 4 Methods Citations 1 View All Figures, Tables, and Topics from this paper table 1 figure 1 table 2 figure 2 figure 3 View All 5 Figures & Tables Phytosterols Cardiovascular Diseases Lipoproteins Lanosterol campesterol Triglycerides Stigmasterol Atherosclerosis Sitosterols lathosterol 21 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency The ABCG5/8 cholesterol transporter and myocardial infarction versus gallstone disease. S. Stender, R. Frikke-Schmidt, B. Nordestgaard, A. 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