[PDF] Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators. | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1152/ajplung.00164.2013 Corpus ID: 6604171Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators. @article{Enomoto2014NewbornRR, title={Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators.}, author={M. Enomoto and A. Jain and J. Pan and Y. Shifrin and T. van Vliet and P. McNamara and R. Jankov and J. Belik}, journal={American journal of physiology. Lung cellular and molecular physiology}, year={2014}, volume={306 2}, pages={ L207-15 } } M. Enomoto, A. Jain, +5 authors J. Belik Published 2014 Medicine American journal of physiology. Lung cellular and molecular physiology Inhaled nitric oxide (NO) and other cGMP- or cAMP-dependent pulmonary vasodilators are often used in combination for the treatment of the persistent pulmonary hypertension of the newborn syndrome. There is in vitro evidence to indicate that NO downregulate the pulmonary vascular response to cGMP-dependent agonists raising concern as to whether a synergistic effect is observed when employing a combined strategy in newborns. Hypothesizing that a synergistic effect is absent, we evaluated newborn… Expand View on PubMed ajplung.physiology.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 11 CitationsBackground Citations 5 Methods Citations 1 Results Citations 1 View All Figures and Topics from this paper figure 1 figure 2 figure 3 figure 4 figure 5 figure 6 figure 7 figure 8 View All 8 Figures & Tables Cyclic GMP sildenafil Pulmonary Hypertension Vasodilator Agents Nitric Oxide Acetylcysteine Colforsin Infant, Newborn Hypoxia Hypertensive disease Persistent Fetal Circulation Syndrome Heat shock proteins Vasodilation disorder Heat-Shock Response Pulmonary artery structure 8-chloro-cyclic adenosine monophosphate Myocytes, Smooth Muscle Guanylate Cyclase Down-Regulation hypersensitivity desensitization Penicillamine Muscle, Smooth, Vascular Smooth muscle (tissue) 11 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Enhanced NO-dependent pulmonary vasodilation limits increased vasoconstrictor sensitivity in neonatal chronic hypoxia. 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