[PDF] Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels. | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1093/hmg/ddu731 Corpus ID: 18089339Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels. @article{Lu2015EvidenceFS, title={Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.}, author={W. Lu and Yu-Ching Cheng and K. Chen and Hong Wang and G. Gerhard and C. Still and Xin Chu and R. Yang and A. Parihar and J. O'Connell and T. Pollin and E. {\'A}ngles-Cano and M. Quon and B. Mitchell and A. Shuldiner and M. Fu}, journal={Human molecular genetics}, year={2015}, volume={24 8}, pages={ 2390-400 } } W. Lu, Yu-Ching Cheng, +13 authors M. Fu Published 2015 Biology, Medicine Human molecular genetics Lipoprotein (a) [Lp(a)] is an independent risk factor for atherosclerosis-related events that is under strong genetic control (heritability = 0.68-0.98). However, causal mutations and functional validation of biological pathways modulating Lp(a) metabolism are lacking. We performed a genome-wide association scan to identify genetic variants associated with Lp(a)-cholesterol levels in the Old Order Amish. We confirmed a previously known locus on chromosome 6q25-26 and found Lp(a) levels also to… Expand View on PubMed academic.oup.com Save to Library Create Alert Cite Launch Research Feed Share This Paper 35 CitationsHighly Influential Citations 1 Background Citations 7 Methods Citations 2 Results Citations 1 View All Figures, Tables, and Topics from this paper table 1 figure 1 figure 2 table 2 figure 3 table 3 table 4 figure 4 figure 5 View All 9 Figures & Tables Cholesterol Lipoprotein (a) Nitroprusside Atherosclerosis chromosome 11q23 LPA gene KREMEN2 gene Null Value Mental association 35 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms[S] Salome Mack, S. Coassin, +24 authors F. Kronenberg Biology, Medicine Journal of Lipid Research 2017 22 PDF View 1 excerpt, cites methods Save Alert Research Feed Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report Mary Hoekstra, H. Chen, +11 authors J. Engert Biology, Medicine Arteriosclerosis, thrombosis, and vascular biology 2020 2 Save Alert Research Feed Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries S. Zekavat, S. Ruotsalainen, +341 authors S. Zoellner Medicine, Biology Nature Communications 2018 38 PDF Save Alert Research Feed Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes. D. Gudbjartsson, G. Thorgeirsson, +29 authors K. Stefánsson Medicine Journal of the American College of Cardiology 2019 19 Save Alert Research Feed Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries S. Zekavat, S. Ruotsalainen, +21 authors P. Natarajan Biology, Medicine 2017 4 PDF Save Alert Research Feed A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction S. Coassin, Gertraud Erhart, +20 authors F. Kronenberg Medicine European heart journal 2017 25 PDF Save Alert Research Feed A novel variant associated with HDL-C levels by modifying DAGLB expression levels: An annotation-based genome-wide association study D. Zhou, Dandan Zhang, +12 authors M. Lai Biology, Medicine European Journal of Human Genetics 2018 5 PDF Save Alert Research Feed Effect of Two Lipoprotein (a)-Associated Genetic Variants on Plasminogen Levels and Fibrinolysis Hong Wang, Chan E Hong, +9 authors M. Fu Biology, Medicine G3: Genes, Genomes, Genetics 2016 3 PDF View 10 excerpts, cites methods, results and background Save Alert Research Feed Lipoprotein (a): impact by ethnicity and environmental and medical conditions B. Enkhmaa, E. Anuurad, L. Berglund Medicine Journal of Lipid Research 2016 50 PDF Save Alert Research Feed Lipoprotein(a) concentration, genetic variants, apo(a) isoform size, and cellular cholesterol efflux in patients with elevated Lp(a) and coronary heart disease submitted or not to lipoprotein apheresis: An Italian case-control multicenter study on Lp(a). C. Stefanutti, L. Pisciotta, +14 authors G. Watts Medicine Journal of clinical lipidology 2020 Save Alert Research Feed ... 1 2 3 4 ... References SHOWING 1-10 OF 61 REFERENCES SORT BYRelevance Most Influenced Papers Recency Genetic variants associated with Lp(a) lipoprotein level and coronary disease. R. Clarke, J. Peden, +20 authors M. Farrall Medicine The New England journal of medicine 2009 975 PDF View 3 excerpts, references results Save Alert Research Feed Multiple QTL influence the serum Lp(a) concentration: a genome-wide linkage screen in the PROCARDIS study S. Barlera, C. Specchia, +11 authors H. 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