[PDF] Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats. | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1152/ajpheart.01180.2011 Corpus ID: 16304866Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats. @article{Peng2012SustainedTH, title={Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats.}, author={Gary Peng and J. Ivanovska and Crystal Kantores and T. van Vliet and D. Engelberts and B. Kavanagh and M. Enomoto and J. Belik and A. Jain and P. McNamara and R. Jankov}, journal={American journal of physiology. Heart and circulatory physiology}, year={2012}, volume={302 12}, pages={ H2599-611 } } Gary Peng, J. Ivanovska, +8 authors R. Jankov Published 2012 Medicine American journal of physiology. Heart and circulatory physiology Sustained therapeutic hypercapnia prevents pulmonary hypertension in experimental animals, but its rescue effects on established disease have not been studied. Therapies that inhibit Rho-kinase (ROCK) and/or augment nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling can reverse or prevent progression of chronic pulmonary hypertension. Our objective in the present study was to determine whether sustained rescue treatment with inhaled CO(2) (therapeutic hypercapnia) would improve… Expand View on PubMed ajpheart.physiology.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 22 CitationsBackground Citations 9 Methods Citations 3 Results Citations 1 View All Figures, Tables, and Topics from this paper table 1 figure 1 figure 3 figure 4 figure 5 figure 6 figure 7 figure 8 figure 9 View All 9 Figures & Tables Pulmonary Hypertension Hypoxia Hypertensive disease Cyclic GMP torr Lung diseases Nitric Oxide Synthase Ventricular hypertrophy Positron-Emission Tomography Guanosine Monophosphate Myocytes, Smooth Muscle Smooth muscle (tissue) Structure of parenchyma of lung Y 27632 Systolic Pressure Guanosine Tetraphosphate Congenital Abnormality 22 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Therapeutic hypercapnia prevents inhaled nitric oxide-induced right-ventricular systolic dysfunction in juvenile rats. Kristyn Dunlop, Kiranjot Gosal, +7 authors R. Jankov Medicine Free radical biology & medicine 2014 16 Save Alert Research Feed Sodium nitrite augments lung S-nitrosylation and reverses chronic hypoxic pulmonary hypertension in juvenile rats. R. Jankov, K. L. Daniel, +4 authors A. Jain Medicine American journal of physiology. Lung cellular and molecular physiology 2018 6 Save Alert Research Feed Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension. Kiranjot Gosal, Kristyn Dunlop, +7 authors R. Jankov Medicine American journal of respiratory cell and molecular biology 2015 10 Save Alert Research Feed Hypercapnia downregulates hypoxia‐induced lysyl oxidase expression in pulmonary artery smooth muscle cells via inhibiting transforming growth factor β1 signalling Xiao-dong Xia, Yanping Peng, Dan Lei, Wei-qian Chen Chemistry, Medicine Cell biochemistry and function 2019 1 View 3 excerpts, cites results and background Save Alert Research Feed Effect of fasudil on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats. X. Sun, S. Li, Xiang-yang Tian, Qing-quan Wu Medicine International journal of clinical and experimental pathology 2015 3 PDF View 1 excerpt, cites background Save Alert Research Feed Rho-kinase inhibitors. Y. Fukumoto, H. Shimokawa Medicine Handbook of experimental pharmacology 2013 20 View 1 excerpt, cites background Save Alert Research Feed Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators. M. Enomoto, A. Jain, +5 authors J. Belik Medicine American journal of physiology. Lung cellular and molecular physiology 2014 11 PDF View 5 excerpts, cites background and methods Save Alert Research Feed Sex-dependent changes in the pulmonary vasoconstriction potential of newborn rats following short-term oxygen exposure M. Enomoto, Kiran Gosal, +4 authors J. Belik Medicine Pediatric Research 2012 21 PDF Save Alert Research Feed Rho-kinase inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation. A. H. Lee, R. Dhaliwal, +5 authors R. Jankov Medicine American journal of respiratory cell and molecular biology 2014 29 View 2 excerpts, cites background Save Alert Research Feed The role of hypercapnia in acute respiratory failure Luis Morales-Quinteros, M. Camprubí-Rimblas, J. Bringué, L. Bos, M. Schultz, A. Artigas Medicine Intensive Care Medicine Experimental 2019 10 Save Alert Research Feed ... 1 2 3 ... References SHOWING 1-10 OF 83 REFERENCES SORT BYRelevance Most Influenced Papers Recency Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Crystal Kantores, P. McNamara, +4 authors R. Jankov Medicine American journal of physiology. Lung cellular and molecular physiology 2006 82 PDF View 9 excerpts, references methods and background Save Alert Research Feed Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide. P. McNamara, P. Murthy, +5 authors R. Jankov Medicine American journal of physiology. Lung cellular and molecular physiology 2008 104 PDF View 5 excerpts, references background and methods Save Alert Research Feed Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat. J. Belik, Danielle Stevens, +6 authors R. Jankov Medicine American journal of physiology. 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McNamara Biology, Medicine Free radical biology & medicine 2010 17 View 2 excerpts, references methods Save Alert Research Feed Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. J. Laffey, M. Tanaka, +6 authors B. Kavanagh Medicine American journal of respiratory and critical care medicine 2000 243 PDF View 1 excerpt, references background Save Alert Research Feed Hypercapnia attenuates hypoxic pulmonary hypertension by inhibiting lung radical injury. M. Chovanec, J. Novotná, J. Wilhelm, V. Hampl, M. Vízek, J. Herget Medicine Physiological research 2009 14 PDF View 2 excerpts, references background Save Alert Research Feed PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation. A. Hemnes, A. Zaiman, H. Champion Medicine American journal of physiology. Lung cellular and molecular physiology 2008 133 View 1 excerpt, references background Save Alert Research Feed Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats. Azhar Masood, M. Yi, +9 authors A. K. Tanswell Medicine American journal of physiology. Lung cellular and molecular physiology 2009 50 PDF View 6 excerpts, references background and methods Save Alert Research Feed ... 1 2 3 4 5 ... Related Papers Abstract Figures, Tables, and Topics 22 Citations 83 References Related Papers Stay Connected With Semantic Scholar Sign Up About Semantic Scholar Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. 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