Improper Adjustment for Baseline in Genetic Association Studies of Change in Phenotype | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1159/000181156 Corpus ID: 2731979Improper Adjustment for Baseline in Genetic Association Studies of Change in Phenotype @article{McArdle2008ImproperAF, title={Improper Adjustment for Baseline in Genetic Association Studies of Change in Phenotype}, author={P. F. McArdle and B. W. Whitcomb}, journal={Human Heredity}, year={2008}, volume={67}, pages={176 - 182} } P.F. McArdle, B.W. Whitcomb Published 2008 Medicine Human Heredity Objective: In studies of associations between genetic factors and outcomes where change in phenotype is of interest, proper modeling of the data, particularly the treatment of baseline trait values, is required to draw valid conclusions. Methods: The authors compared models of blood pressure response to a cold pressor test with and without inclusion of baseline blood pressure as a regressor and evaluate the resultant biases. Results: Adjustment for baseline presents a potential source of bias… Expand View on PubMed karger.com Save to Library Create Alert Cite Launch Research Feed Share This Paper 7 Citations Methods Citations 1 View All Figures, Tables, and Topics from this paper figure 1 table 1 table 2 figure 2 table 3 figure 3 table 4 View All 7 Figures & Tables Mental association Estimated Population Parameter Genetic Association Studies BaseLine dental cement 7 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change A. Oni-Orisan, Tanushree Haldar, +6 authors Thomas J. 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