[PDF] Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1161/STROKEAHA.111.000217 Corpus ID: 5761459Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis @article{Markus2013EvidenceHG, title={Evidence HDAC9 Genetic Variant Associated With Ischemic Stroke Increases Risk via Promoting Carotid Atherosclerosis}, author={H. Markus and Kari-Matti M{\"a}kel{\"a} and S. Bevan and E. Raitoharju and N. Oksala and J. Bis and C. O'Donnell and A. Hainsworth and T. Lehtim{\"a}ki}, journal={Stroke}, year={2013}, volume={44}, pages={1220–1225} } H. Markus, Kari-Matti Mäkelä, +6 authors T. Lehtimäki Published 2013 Medicine Stroke Background and Purpose— A novel association between a single nucleotide polymorphism on chromosome 7p21.1 and large-vessel ischemic stroke was recently identified. The most likely underlying gene is histone deacetylase 9 (HDAC9). The mechanism by which HDAC9 increases stroke risk is not clear; both vascular and neuronal mechanisms have been proposed. Methods— We determined whether the lead single nucleotide polymorphisms were associated with asymptomatic carotid plaque (N=25 179) and carotid… Expand View on Wolters Kluwer ahajournals.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 67 CitationsHighly Influential Citations 1 Background Citations 11 View All Figures, Tables, and Topics from this paper table 1 figure 1 table 2 figure 2 table 3 table 4 View All 6 Figures & Tables Atherosclerosis Cerebral Infarction HDAC9 gene Senile Plaques Cerebrovascular accident Myocytes, Smooth Muscle Promotion (action) Smooth muscle (tissue) Muscle Cells Chest Plaque, Atherosclerotic 67 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Deficiency of the Stroke Relevant HDAC9 Gene Attenuates Atherosclerosis in Accord With Allele-Specific Effects at 7p21.1 Sepiede Azghandi, C. 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