id sid tid token lemma pos work_y6xvhkczvjdslpwrorji4thpga 1 1 What what WP work_y6xvhkczvjdslpwrorji4thpga 1 2 the the DT work_y6xvhkczvjdslpwrorji4thpga 1 3 Amish Amish NNP work_y6xvhkczvjdslpwrorji4thpga 1 4 can can MD work_y6xvhkczvjdslpwrorji4thpga 1 5 tell tell VB work_y6xvhkczvjdslpwrorji4thpga 1 6 us -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 1 7 about about IN work_y6xvhkczvjdslpwrorji4thpga 1 8 … … NFP work_y6xvhkczvjdslpwrorji4thpga 1 9 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 1 10 HEPATOLOGY HEPATOLOGY NNP work_y6xvhkczvjdslpwrorji4thpga 1 11 Elsewhere Elsewhere NNP work_y6xvhkczvjdslpwrorji4thpga 1 12 JACQUELYN JACQUELYN NNP work_y6xvhkczvjdslpwrorji4thpga 1 13 MAHER MAHER NNS work_y6xvhkczvjdslpwrorji4thpga 1 14 , , , work_y6xvhkczvjdslpwrorji4thpga 1 15 EDITOR EDITOR NNP work_y6xvhkczvjdslpwrorji4thpga 1 16 San San NNP work_y6xvhkczvjdslpwrorji4thpga 1 17 Francisco Francisco NNP work_y6xvhkczvjdslpwrorji4thpga 1 18 General General NNP work_y6xvhkczvjdslpwrorji4thpga 1 19 Hospital Hospital NNP work_y6xvhkczvjdslpwrorji4thpga 1 20 Building Building NNP work_y6xvhkczvjdslpwrorji4thpga 1 21 40 40 CD work_y6xvhkczvjdslpwrorji4thpga 1 22 , , , work_y6xvhkczvjdslpwrorji4thpga 1 23 Room Room NNP work_y6xvhkczvjdslpwrorji4thpga 1 24 4102 4102 CD work_y6xvhkczvjdslpwrorji4thpga 1 25 1001 1001 CD work_y6xvhkczvjdslpwrorji4thpga 1 26 Potrero Potrero NNP work_y6xvhkczvjdslpwrorji4thpga 1 27 Avenue Avenue NNP work_y6xvhkczvjdslpwrorji4thpga 1 28 San San NNP work_y6xvhkczvjdslpwrorji4thpga 1 29 Francisco Francisco NNP work_y6xvhkczvjdslpwrorji4thpga 1 30 , , , work_y6xvhkczvjdslpwrorji4thpga 1 31 CA CA NNP work_y6xvhkczvjdslpwrorji4thpga 1 32 94110 94110 CD work_y6xvhkczvjdslpwrorji4thpga 1 33 ADVISORY ADVISORY NNP work_y6xvhkczvjdslpwrorji4thpga 1 34 COMMITTEE COMMITTEE NNP work_y6xvhkczvjdslpwrorji4thpga 1 35 LAURIE LAURIE NNP work_y6xvhkczvjdslpwrorji4thpga 1 36 DE DE NNP work_y6xvhkczvjdslpwrorji4thpga 1 37 LEVE LEVE NNP work_y6xvhkczvjdslpwrorji4thpga 1 38 , , , work_y6xvhkczvjdslpwrorji4thpga 1 39 Los Los NNP work_y6xvhkczvjdslpwrorji4thpga 1 40 Angeles Angeles NNP work_y6xvhkczvjdslpwrorji4thpga 1 41 , , , work_y6xvhkczvjdslpwrorji4thpga 1 42 CA CA NNP work_y6xvhkczvjdslpwrorji4thpga 1 43 DAVID DAVID NNP work_y6xvhkczvjdslpwrorji4thpga 1 44 CRABB CRABB NNP work_y6xvhkczvjdslpwrorji4thpga 1 45 , , , work_y6xvhkczvjdslpwrorji4thpga 1 46 Indianapolis Indianapolis NNP work_y6xvhkczvjdslpwrorji4thpga 1 47 , , , work_y6xvhkczvjdslpwrorji4thpga 1 48 IN in IN work_y6xvhkczvjdslpwrorji4thpga 1 49 ADRIAN ADRIAN NNP work_y6xvhkczvjdslpwrorji4thpga 1 50 DIBISCEGLIE DIBISCEGLIE NNP work_y6xvhkczvjdslpwrorji4thpga 1 51 , , , work_y6xvhkczvjdslpwrorji4thpga 1 52 St. St. NNP work_y6xvhkczvjdslpwrorji4thpga 1 53 Louis Louis NNP work_y6xvhkczvjdslpwrorji4thpga 1 54 , , , work_y6xvhkczvjdslpwrorji4thpga 1 55 MO MO NNP work_y6xvhkczvjdslpwrorji4thpga 1 56 EMMET EMMET NNP work_y6xvhkczvjdslpwrorji4thpga 1 57 KEEFFE KEEFFE NNP work_y6xvhkczvjdslpwrorji4thpga 1 58 , , , work_y6xvhkczvjdslpwrorji4thpga 1 59 Palo Palo NNP work_y6xvhkczvjdslpwrorji4thpga 1 60 Alto Alto NNP work_y6xvhkczvjdslpwrorji4thpga 1 61 , , , work_y6xvhkczvjdslpwrorji4thpga 1 62 CA CA NNP work_y6xvhkczvjdslpwrorji4thpga 1 63 JOEL JOEL NNP work_y6xvhkczvjdslpwrorji4thpga 1 64 LAVINE LAVINE NNP work_y6xvhkczvjdslpwrorji4thpga 1 65 , , , work_y6xvhkczvjdslpwrorji4thpga 1 66 San San NNP work_y6xvhkczvjdslpwrorji4thpga 1 67 Diego Diego NNP work_y6xvhkczvjdslpwrorji4thpga 1 68 , , , work_y6xvhkczvjdslpwrorji4thpga 1 69 CA CA NNP work_y6xvhkczvjdslpwrorji4thpga 1 70 MICHAEL MICHAEL NNP work_y6xvhkczvjdslpwrorji4thpga 1 71 NATHANSON NATHANSON NNP work_y6xvhkczvjdslpwrorji4thpga 1 72 , , , work_y6xvhkczvjdslpwrorji4thpga 1 73 New New NNP work_y6xvhkczvjdslpwrorji4thpga 1 74 Haven Haven NNP work_y6xvhkczvjdslpwrorji4thpga 1 75 , , , work_y6xvhkczvjdslpwrorji4thpga 1 76 CT CT NNP work_y6xvhkczvjdslpwrorji4thpga 1 77 DON DON NNP work_y6xvhkczvjdslpwrorji4thpga 1 78 ROCKEY ROCKEY NNP work_y6xvhkczvjdslpwrorji4thpga 1 79 , , , work_y6xvhkczvjdslpwrorji4thpga 1 80 Durham Durham NNP work_y6xvhkczvjdslpwrorji4thpga 1 81 , , , work_y6xvhkczvjdslpwrorji4thpga 1 82 NC NC NNP work_y6xvhkczvjdslpwrorji4thpga 1 83 DWAIN DWAIN NNP work_y6xvhkczvjdslpwrorji4thpga 1 84 THIELE THIELE NNP work_y6xvhkczvjdslpwrorji4thpga 1 85 , , , work_y6xvhkczvjdslpwrorji4thpga 1 86 Dallas Dallas NNP work_y6xvhkczvjdslpwrorji4thpga 1 87 , , , work_y6xvhkczvjdslpwrorji4thpga 1 88 TX TX NNP work_y6xvhkczvjdslpwrorji4thpga 1 89 WHAT what WP work_y6xvhkczvjdslpwrorji4thpga 1 90 THE the DT work_y6xvhkczvjdslpwrorji4thpga 1 91 AMISH AMISH NNS work_y6xvhkczvjdslpwrorji4thpga 1 92 CAN CAN MD work_y6xvhkczvjdslpwrorji4thpga 1 93 TELL tell VB work_y6xvhkczvjdslpwrorji4thpga 1 94 US US NNP work_y6xvhkczvjdslpwrorji4thpga 1 95 ABOUT about IN work_y6xvhkczvjdslpwrorji4thpga 1 96 . . . work_y6xvhkczvjdslpwrorji4thpga 2 1 . . . work_y6xvhkczvjdslpwrorji4thpga 3 1 . . . work_y6xvhkczvjdslpwrorji4thpga 4 1 CHOLESTASIS CHOLESTASIS NNP work_y6xvhkczvjdslpwrorji4thpga 4 2 Bull Bull NNP work_y6xvhkczvjdslpwrorji4thpga 4 3 LN LN NNP work_y6xvhkczvjdslpwrorji4thpga 4 4 , , , work_y6xvhkczvjdslpwrorji4thpga 4 5 van van NNP work_y6xvhkczvjdslpwrorji4thpga 4 6 Eijk Eijk NNP work_y6xvhkczvjdslpwrorji4thpga 4 7 MJT MJT NNP work_y6xvhkczvjdslpwrorji4thpga 4 8 , , , work_y6xvhkczvjdslpwrorji4thpga 4 9 Pawlikowska Pawlikowska NNP work_y6xvhkczvjdslpwrorji4thpga 4 10 L L NNP work_y6xvhkczvjdslpwrorji4thpga 4 11 , , , work_y6xvhkczvjdslpwrorji4thpga 4 12 DeYoung DeYoung NNP work_y6xvhkczvjdslpwrorji4thpga 4 13 JA JA NNP work_y6xvhkczvjdslpwrorji4thpga 4 14 , , , work_y6xvhkczvjdslpwrorji4thpga 4 15 Juijn Juijn NNP work_y6xvhkczvjdslpwrorji4thpga 4 16 JA JA NNP work_y6xvhkczvjdslpwrorji4thpga 4 17 , , , work_y6xvhkczvjdslpwrorji4thpga 4 18 Liao Liao NNP work_y6xvhkczvjdslpwrorji4thpga 4 19 M M NNP work_y6xvhkczvjdslpwrorji4thpga 4 20 , , , work_y6xvhkczvjdslpwrorji4thpga 4 21 Klomp Klomp NNP work_y6xvhkczvjdslpwrorji4thpga 4 22 LWJ LWJ NNP work_y6xvhkczvjdslpwrorji4thpga 4 23 , , , work_y6xvhkczvjdslpwrorji4thpga 4 24 Lomri Lomri NNP work_y6xvhkczvjdslpwrorji4thpga 4 25 N N NNP work_y6xvhkczvjdslpwrorji4thpga 4 26 , , , work_y6xvhkczvjdslpwrorji4thpga 4 27 Berger Berger NNP work_y6xvhkczvjdslpwrorji4thpga 4 28 R R NNP work_y6xvhkczvjdslpwrorji4thpga 4 29 , , , work_y6xvhkczvjdslpwrorji4thpga 4 30 Scharschmidt Scharschmidt NNP work_y6xvhkczvjdslpwrorji4thpga 4 31 BF BF NNP work_y6xvhkczvjdslpwrorji4thpga 4 32 , , , work_y6xvhkczvjdslpwrorji4thpga 4 33 Knisely Knisely NNP work_y6xvhkczvjdslpwrorji4thpga 4 34 AS AS NNP work_y6xvhkczvjdslpwrorji4thpga 4 35 , , , work_y6xvhkczvjdslpwrorji4thpga 4 36 Houwen Houwen NNP work_y6xvhkczvjdslpwrorji4thpga 4 37 RHJ RHJ NNP work_y6xvhkczvjdslpwrorji4thpga 4 38 , , , work_y6xvhkczvjdslpwrorji4thpga 4 39 Freimer Freimer NNP work_y6xvhkczvjdslpwrorji4thpga 4 40 NB NB NNP work_y6xvhkczvjdslpwrorji4thpga 4 41 . . . work_y6xvhkczvjdslpwrorji4thpga 5 1 A a DT work_y6xvhkczvjdslpwrorji4thpga 5 2 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 5 3 encoding encode VBG work_y6xvhkczvjdslpwrorji4thpga 5 4 a a DT work_y6xvhkczvjdslpwrorji4thpga 5 5 P p NN work_y6xvhkczvjdslpwrorji4thpga 5 6 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 5 7 type type NN work_y6xvhkczvjdslpwrorji4thpga 5 8 ATPase ATPase NNP work_y6xvhkczvjdslpwrorji4thpga 5 9 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 5 10 mutated mutate VBN work_y6xvhkczvjdslpwrorji4thpga 5 11 in in IN work_y6xvhkczvjdslpwrorji4thpga 5 12 two two CD work_y6xvhkczvjdslpwrorji4thpga 5 13 forms form NNS work_y6xvhkczvjdslpwrorji4thpga 5 14 of of IN work_y6xvhkczvjdslpwrorji4thpga 5 15 hereditary hereditary JJ work_y6xvhkczvjdslpwrorji4thpga 5 16 cholesta- cholesta- NN work_y6xvhkczvjdslpwrorji4thpga 5 17 sis sis NN work_y6xvhkczvjdslpwrorji4thpga 5 18 . . . work_y6xvhkczvjdslpwrorji4thpga 6 1 Nat Nat NNP work_y6xvhkczvjdslpwrorji4thpga 6 2 Genet Genet NNP work_y6xvhkczvjdslpwrorji4thpga 6 3 1998;18:219 1998;18:219 CD work_y6xvhkczvjdslpwrorji4thpga 6 4 - - SYM work_y6xvhkczvjdslpwrorji4thpga 6 5 224 224 CD work_y6xvhkczvjdslpwrorji4thpga 6 6 . . . work_y6xvhkczvjdslpwrorji4thpga 7 1 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 7 2 Reprinted reprint VBN work_y6xvhkczvjdslpwrorji4thpga 7 3 with with IN work_y6xvhkczvjdslpwrorji4thpga 7 4 permission permission NN work_y6xvhkczvjdslpwrorji4thpga 7 5 . . . work_y6xvhkczvjdslpwrorji4thpga 7 6 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 8 1 ABSTRACT ABSTRACT NNP work_y6xvhkczvjdslpwrorji4thpga 8 2 Cholestasis Cholestasis NNP work_y6xvhkczvjdslpwrorji4thpga 8 3 , , , work_y6xvhkczvjdslpwrorji4thpga 8 4 or or CC work_y6xvhkczvjdslpwrorji4thpga 8 5 impaired impair VBN work_y6xvhkczvjdslpwrorji4thpga 8 6 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 8 7 flow flow NN work_y6xvhkczvjdslpwrorji4thpga 8 8 , , , work_y6xvhkczvjdslpwrorji4thpga 8 9 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 8 10 an an DT work_y6xvhkczvjdslpwrorji4thpga 8 11 important important JJ work_y6xvhkczvjdslpwrorji4thpga 8 12 but but CC work_y6xvhkczvjdslpwrorji4thpga 8 13 poorly poorly RB work_y6xvhkczvjdslpwrorji4thpga 8 14 understood understand VBN work_y6xvhkczvjdslpwrorji4thpga 8 15 manifestation manifestation NN work_y6xvhkczvjdslpwrorji4thpga 8 16 of of IN work_y6xvhkczvjdslpwrorji4thpga 8 17 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 8 18 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 8 19 . . . work_y6xvhkczvjdslpwrorji4thpga 9 1 Two two CD work_y6xvhkczvjdslpwrorji4thpga 9 2 clinically clinically RB work_y6xvhkczvjdslpwrorji4thpga 9 3 distinct distinct JJ work_y6xvhkczvjdslpwrorji4thpga 9 4 forms form NNS work_y6xvhkczvjdslpwrorji4thpga 9 5 of of IN work_y6xvhkczvjdslpwrorji4thpga 9 6 inherited inherit VBN work_y6xvhkczvjdslpwrorji4thpga 9 7 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 9 8 , , , work_y6xvhkczvjdslpwrorji4thpga 9 9 benign benign JJ work_y6xvhkczvjdslpwrorji4thpga 9 10 recurrent recurrent JJ work_y6xvhkczvjdslpwrorji4thpga 9 11 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 9 12 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 9 13 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 9 14 BRIC bric NN work_y6xvhkczvjdslpwrorji4thpga 9 15 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 9 16 and and CC work_y6xvhkczvjdslpwrorji4thpga 9 17 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 9 18 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 9 19 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 9 20 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 9 21 type type NN work_y6xvhkczvjdslpwrorji4thpga 9 22 1 1 CD work_y6xvhkczvjdslpwrorji4thpga 9 23 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 9 24 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 9 25 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 9 26 , , , work_y6xvhkczvjdslpwrorji4thpga 9 27 were be VBD work_y6xvhkczvjdslpwrorji4thpga 9 28 previ- previ- JJ work_y6xvhkczvjdslpwrorji4thpga 9 29 ously ously RB work_y6xvhkczvjdslpwrorji4thpga 9 30 mapped map VBN work_y6xvhkczvjdslpwrorji4thpga 9 31 to to IN work_y6xvhkczvjdslpwrorji4thpga 9 32 18q21 18q21 CD work_y6xvhkczvjdslpwrorji4thpga 9 33 . . . work_y6xvhkczvjdslpwrorji4thpga 10 1 Haplotype Haplotype NNP work_y6xvhkczvjdslpwrorji4thpga 10 2 analysis analysis NN work_y6xvhkczvjdslpwrorji4thpga 10 3 narrowed narrow VBD work_y6xvhkczvjdslpwrorji4thpga 10 4 the the DT work_y6xvhkczvjdslpwrorji4thpga 10 5 candidate candidate NN work_y6xvhkczvjdslpwrorji4thpga 10 6 region region NN work_y6xvhkczvjdslpwrorji4thpga 10 7 for for IN work_y6xvhkczvjdslpwrorji4thpga 10 8 both both DT work_y6xvhkczvjdslpwrorji4thpga 10 9 diseases disease NNS work_y6xvhkczvjdslpwrorji4thpga 10 10 to to IN work_y6xvhkczvjdslpwrorji4thpga 10 11 the the DT work_y6xvhkczvjdslpwrorji4thpga 10 12 same same JJ work_y6xvhkczvjdslpwrorji4thpga 10 13 interval interval NN work_y6xvhkczvjdslpwrorji4thpga 10 14 of of IN work_y6xvhkczvjdslpwrorji4thpga 10 15 less less JJR work_y6xvhkczvjdslpwrorji4thpga 10 16 than than IN work_y6xvhkczvjdslpwrorji4thpga 10 17 1 1 CD work_y6xvhkczvjdslpwrorji4thpga 10 18 cM cm NN work_y6xvhkczvjdslpwrorji4thpga 10 19 , , , work_y6xvhkczvjdslpwrorji4thpga 10 20 in in IN work_y6xvhkczvjdslpwrorji4thpga 10 21 which which WDT work_y6xvhkczvjdslpwrorji4thpga 10 22 we -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 10 23 identified identify VBD work_y6xvhkczvjdslpwrorji4thpga 10 24 a a DT work_y6xvhkczvjdslpwrorji4thpga 10 25 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 10 26 mutated mutate VBN work_y6xvhkczvjdslpwrorji4thpga 10 27 in in IN work_y6xvhkczvjdslpwrorji4thpga 10 28 BRIC BRIC NNP work_y6xvhkczvjdslpwrorji4thpga 10 29 and and CC work_y6xvhkczvjdslpwrorji4thpga 10 30 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 10 31 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 10 32 . . . work_y6xvhkczvjdslpwrorji4thpga 11 1 This this DT work_y6xvhkczvjdslpwrorji4thpga 11 2 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 11 3 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 11 4 called call VBN work_y6xvhkczvjdslpwrorji4thpga 11 5 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 11 6 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 11 7 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 11 8 the the DT work_y6xvhkczvjdslpwrorji4thpga 11 9 first first JJ work_y6xvhkczvjdslpwrorji4thpga 11 10 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 11 11 human human JJ work_y6xvhkczvjdslpwrorji4thpga 11 12 member member NN work_y6xvhkczvjdslpwrorji4thpga 11 13 of of IN work_y6xvhkczvjdslpwrorji4thpga 11 14 a a DT work_y6xvhkczvjdslpwrorji4thpga 11 15 recently recently RB work_y6xvhkczvjdslpwrorji4thpga 11 16 described describe VBN work_y6xvhkczvjdslpwrorji4thpga 11 17 subfamily subfamily RB work_y6xvhkczvjdslpwrorji4thpga 11 18 of of IN work_y6xvhkczvjdslpwrorji4thpga 11 19 P p NN work_y6xvhkczvjdslpwrorji4thpga 11 20 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 11 21 type type NN work_y6xvhkczvjdslpwrorji4thpga 11 22 ATPases atpase NNS work_y6xvhkczvjdslpwrorji4thpga 11 23 ; ; : work_y6xvhkczvjdslpwrorji4thpga 11 24 ATP atp NN work_y6xvhkczvjdslpwrorji4thpga 11 25 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 11 26 dependent dependent JJ work_y6xvhkczvjdslpwrorji4thpga 11 27 aminophospho- aminophospho- NNP work_y6xvhkczvjdslpwrorji4thpga 11 28 lipid lipid NN work_y6xvhkczvjdslpwrorji4thpga 11 29 transport transport NN work_y6xvhkczvjdslpwrorji4thpga 11 30 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 11 31 the the DT work_y6xvhkczvjdslpwrorji4thpga 11 32 previously previously RB work_y6xvhkczvjdslpwrorji4thpga 11 33 described describe VBN work_y6xvhkczvjdslpwrorji4thpga 11 34 function function NN work_y6xvhkczvjdslpwrorji4thpga 11 35 of of IN work_y6xvhkczvjdslpwrorji4thpga 11 36 members member NNS work_y6xvhkczvjdslpwrorji4thpga 11 37 of of IN work_y6xvhkczvjdslpwrorji4thpga 11 38 this this DT work_y6xvhkczvjdslpwrorji4thpga 11 39 subfamily subfamily NN work_y6xvhkczvjdslpwrorji4thpga 11 40 . . . work_y6xvhkczvjdslpwrorji4thpga 12 1 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 12 2 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 12 3 expressed express VBN work_y6xvhkczvjdslpwrorji4thpga 12 4 in in IN work_y6xvhkczvjdslpwrorji4thpga 12 5 several several JJ work_y6xvhkczvjdslpwrorji4thpga 12 6 epithelial epithelial JJ work_y6xvhkczvjdslpwrorji4thpga 12 7 tissues tissue NNS work_y6xvhkczvjdslpwrorji4thpga 12 8 and and CC work_y6xvhkczvjdslpwrorji4thpga 12 9 , , , work_y6xvhkczvjdslpwrorji4thpga 12 10 surprisingly surprisingly RB work_y6xvhkczvjdslpwrorji4thpga 12 11 , , , work_y6xvhkczvjdslpwrorji4thpga 12 12 more more RBR work_y6xvhkczvjdslpwrorji4thpga 12 13 strongly strongly RB work_y6xvhkczvjdslpwrorji4thpga 12 14 in in IN work_y6xvhkczvjdslpwrorji4thpga 12 15 small small JJ work_y6xvhkczvjdslpwrorji4thpga 12 16 intestine intestine NN work_y6xvhkczvjdslpwrorji4thpga 12 17 than than IN work_y6xvhkczvjdslpwrorji4thpga 12 18 in in IN work_y6xvhkczvjdslpwrorji4thpga 12 19 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 12 20 . . . work_y6xvhkczvjdslpwrorji4thpga 13 1 Its -PRON- PRP$ work_y6xvhkczvjdslpwrorji4thpga 13 2 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 13 3 product product NN work_y6xvhkczvjdslpwrorji4thpga 13 4 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 13 5 likely likely JJ work_y6xvhkczvjdslpwrorji4thpga 13 6 to to TO work_y6xvhkczvjdslpwrorji4thpga 13 7 play play VB work_y6xvhkczvjdslpwrorji4thpga 13 8 an an DT work_y6xvhkczvjdslpwrorji4thpga 13 9 essential essential JJ work_y6xvhkczvjdslpwrorji4thpga 13 10 role role NN work_y6xvhkczvjdslpwrorji4thpga 13 11 in in IN work_y6xvhkczvjdslpwrorji4thpga 13 12 enterohepatic enterohepatic JJ work_y6xvhkczvjdslpwrorji4thpga 13 13 circulation circulation NN work_y6xvhkczvjdslpwrorji4thpga 13 14 of of IN work_y6xvhkczvjdslpwrorji4thpga 13 15 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 13 16 acids acid NNS work_y6xvhkczvjdslpwrorji4thpga 13 17 ; ; : work_y6xvhkczvjdslpwrorji4thpga 13 18 further further JJ work_y6xvhkczvjdslpwrorji4thpga 13 19 characterization characterization NN work_y6xvhkczvjdslpwrorji4thpga 13 20 of of IN work_y6xvhkczvjdslpwrorji4thpga 13 21 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 13 22 will will MD work_y6xvhkczvjdslpwrorji4thpga 13 23 facilitate facilitate VB work_y6xvhkczvjdslpwrorji4thpga 13 24 understand- understand- JJ work_y6xvhkczvjdslpwrorji4thpga 13 25 ing ing NN work_y6xvhkczvjdslpwrorji4thpga 13 26 of of IN work_y6xvhkczvjdslpwrorji4thpga 13 27 normal normal JJ work_y6xvhkczvjdslpwrorji4thpga 13 28 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 13 29 formation formation NN work_y6xvhkczvjdslpwrorji4thpga 13 30 and and CC work_y6xvhkczvjdslpwrorji4thpga 13 31 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 13 32 . . . work_y6xvhkczvjdslpwrorji4thpga 14 1 de de NNP work_y6xvhkczvjdslpwrorji4thpga 14 2 Vree Vree NNP work_y6xvhkczvjdslpwrorji4thpga 14 3 JML JML NNP work_y6xvhkczvjdslpwrorji4thpga 14 4 , , , work_y6xvhkczvjdslpwrorji4thpga 14 5 Jacquemin Jacquemin NNP work_y6xvhkczvjdslpwrorji4thpga 14 6 E E NNP work_y6xvhkczvjdslpwrorji4thpga 14 7 , , , work_y6xvhkczvjdslpwrorji4thpga 14 8 Sturm Sturm NNP work_y6xvhkczvjdslpwrorji4thpga 14 9 E E NNP work_y6xvhkczvjdslpwrorji4thpga 14 10 , , , work_y6xvhkczvjdslpwrorji4thpga 14 11 Cresteil Cresteil NNP work_y6xvhkczvjdslpwrorji4thpga 14 12 D D NNP work_y6xvhkczvjdslpwrorji4thpga 14 13 , , , work_y6xvhkczvjdslpwrorji4thpga 14 14 Bosma Bosma NNP work_y6xvhkczvjdslpwrorji4thpga 14 15 PJ PJ NNP work_y6xvhkczvjdslpwrorji4thpga 14 16 , , , work_y6xvhkczvjdslpwrorji4thpga 14 17 Aten Aten NNP work_y6xvhkczvjdslpwrorji4thpga 14 18 J J NNP work_y6xvhkczvjdslpwrorji4thpga 14 19 , , , work_y6xvhkczvjdslpwrorji4thpga 14 20 Deleuze Deleuze NNP work_y6xvhkczvjdslpwrorji4thpga 14 21 J J NNP work_y6xvhkczvjdslpwrorji4thpga 14 22 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 14 23 F F NNP work_y6xvhkczvjdslpwrorji4thpga 14 24 , , , work_y6xvhkczvjdslpwrorji4thpga 14 25 Desrochers Desrochers NNP work_y6xvhkczvjdslpwrorji4thpga 14 26 M M NNP work_y6xvhkczvjdslpwrorji4thpga 14 27 , , , work_y6xvhkczvjdslpwrorji4thpga 14 28 Burdelski Burdelski NNP work_y6xvhkczvjdslpwrorji4thpga 14 29 M M NNP work_y6xvhkczvjdslpwrorji4thpga 14 30 , , , work_y6xvhkczvjdslpwrorji4thpga 14 31 Bernard Bernard NNP work_y6xvhkczvjdslpwrorji4thpga 14 32 O O NNP work_y6xvhkczvjdslpwrorji4thpga 14 33 , , , work_y6xvhkczvjdslpwrorji4thpga 14 34 Oude Oude NNP work_y6xvhkczvjdslpwrorji4thpga 14 35 Elferink Elferink NNP work_y6xvhkczvjdslpwrorji4thpga 14 36 RPJ RPJ NNP work_y6xvhkczvjdslpwrorji4thpga 14 37 , , , work_y6xvhkczvjdslpwrorji4thpga 14 38 Hadchouel Hadchouel NNP work_y6xvhkczvjdslpwrorji4thpga 14 39 M. M. NNP work_y6xvhkczvjdslpwrorji4thpga 14 40 Mutations Mutations NNP work_y6xvhkczvjdslpwrorji4thpga 14 41 in in IN work_y6xvhkczvjdslpwrorji4thpga 14 42 the the DT work_y6xvhkczvjdslpwrorji4thpga 14 43 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 14 44 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 14 45 cause cause NN work_y6xvhkczvjdslpwrorji4thpga 14 46 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 14 47 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 14 48 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 14 49 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 14 50 . . . work_y6xvhkczvjdslpwrorji4thpga 15 1 Proc Proc NNP work_y6xvhkczvjdslpwrorji4thpga 15 2 Natl Natl NNP work_y6xvhkczvjdslpwrorji4thpga 15 3 Acad Acad NNP work_y6xvhkczvjdslpwrorji4thpga 15 4 Sci Sci NNP work_y6xvhkczvjdslpwrorji4thpga 15 5 U U NNP work_y6xvhkczvjdslpwrorji4thpga 15 6 S S NNP work_y6xvhkczvjdslpwrorji4thpga 15 7 A a DT work_y6xvhkczvjdslpwrorji4thpga 15 8 1998;95:282 1998;95:282 CD work_y6xvhkczvjdslpwrorji4thpga 15 9 - - SYM work_y6xvhkczvjdslpwrorji4thpga 15 10 287 287 CD work_y6xvhkczvjdslpwrorji4thpga 15 11 . . . work_y6xvhkczvjdslpwrorji4thpga 16 1 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 16 2 Reprinted reprint VBN work_y6xvhkczvjdslpwrorji4thpga 16 3 with with IN work_y6xvhkczvjdslpwrorji4thpga 16 4 permission permission NN work_y6xvhkczvjdslpwrorji4thpga 16 5 . . . work_y6xvhkczvjdslpwrorji4thpga 16 6 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 17 1 ABSTRACT ABSTRACT NNP work_y6xvhkczvjdslpwrorji4thpga 17 2 Class Class NNP work_y6xvhkczvjdslpwrorji4thpga 17 3 III iii CD work_y6xvhkczvjdslpwrorji4thpga 17 4 multidrug multidrug NN work_y6xvhkczvjdslpwrorji4thpga 17 5 resistance resistance NN work_y6xvhkczvjdslpwrorji4thpga 17 6 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 17 7 MDR MDR NNP work_y6xvhkczvjdslpwrorji4thpga 17 8 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 17 9 P p NN work_y6xvhkczvjdslpwrorji4thpga 17 10 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 17 11 glycoproteins glycoprotein NNS work_y6xvhkczvjdslpwrorji4thpga 17 12 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 17 13 P P NNP work_y6xvhkczvjdslpwrorji4thpga 17 14 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 17 15 gp gp NNP work_y6xvhkczvjdslpwrorji4thpga 17 16 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 17 17 , , , work_y6xvhkczvjdslpwrorji4thpga 17 18 mdr2 mdr2 NNP work_y6xvhkczvjdslpwrorji4thpga 17 19 in in IN work_y6xvhkczvjdslpwrorji4thpga 17 20 mice mouse NNS work_y6xvhkczvjdslpwrorji4thpga 17 21 and and CC work_y6xvhkczvjdslpwrorji4thpga 17 22 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 17 23 in in IN work_y6xvhkczvjdslpwrorji4thpga 17 24 man man NN work_y6xvhkczvjdslpwrorji4thpga 17 25 , , , work_y6xvhkczvjdslpwrorji4thpga 17 26 mediate mediate VB work_y6xvhkczvjdslpwrorji4thpga 17 27 the the DT work_y6xvhkczvjdslpwrorji4thpga 17 28 translocation translocation NN work_y6xvhkczvjdslpwrorji4thpga 17 29 of of IN work_y6xvhkczvjdslpwrorji4thpga 17 30 phosphatidylcholine phosphatidylcholine NN work_y6xvhkczvjdslpwrorji4thpga 17 31 across across IN work_y6xvhkczvjdslpwrorji4thpga 17 32 the the DT work_y6xvhkczvjdslpwrorji4thpga 17 33 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 17 34 membrane membrane NN work_y6xvhkczvjdslpwrorji4thpga 17 35 of of IN work_y6xvhkczvjdslpwrorji4thpga 17 36 the the DT work_y6xvhkczvjdslpwrorji4thpga 17 37 hepatocyte hepatocyte NN work_y6xvhkczvjdslpwrorji4thpga 17 38 . . . work_y6xvhkczvjdslpwrorji4thpga 18 1 Mice mouse NNS work_y6xvhkczvjdslpwrorji4thpga 18 2 with with IN work_y6xvhkczvjdslpwrorji4thpga 18 3 a a DT work_y6xvhkczvjdslpwrorji4thpga 18 4 disrupted disrupt VBN work_y6xvhkczvjdslpwrorji4thpga 18 5 mdr2 mdr2 NN work_y6xvhkczvjdslpwrorji4thpga 18 6 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 18 7 completely completely RB work_y6xvhkczvjdslpwrorji4thpga 18 8 lack lack VBP work_y6xvhkczvjdslpwrorji4thpga 18 9 biliary biliary JJ work_y6xvhkczvjdslpwrorji4thpga 18 10 phospholipid phospholipid NN work_y6xvhkczvjdslpwrorji4thpga 18 11 excretion excretion NN work_y6xvhkczvjdslpwrorji4thpga 18 12 and and CC work_y6xvhkczvjdslpwrorji4thpga 18 13 develop develop VB work_y6xvhkczvjdslpwrorji4thpga 18 14 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 18 15 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 18 16 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 18 17 , , , work_y6xvhkczvjdslpwrorji4thpga 18 18 characterized characterize VBD work_y6xvhkczvjdslpwrorji4thpga 18 19 histologi- histologi- NN work_y6xvhkczvjdslpwrorji4thpga 18 20 cally cally RB work_y6xvhkczvjdslpwrorji4thpga 18 21 by by IN work_y6xvhkczvjdslpwrorji4thpga 18 22 portal portal JJ work_y6xvhkczvjdslpwrorji4thpga 18 23 inflammation inflammation NN work_y6xvhkczvjdslpwrorji4thpga 18 24 , , , work_y6xvhkczvjdslpwrorji4thpga 18 25 proliferation proliferation NN work_y6xvhkczvjdslpwrorji4thpga 18 26 of of IN work_y6xvhkczvjdslpwrorji4thpga 18 27 the the DT work_y6xvhkczvjdslpwrorji4thpga 18 28 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 18 29 duct duct NN work_y6xvhkczvjdslpwrorji4thpga 18 30 epithelium epithelium NN work_y6xvhkczvjdslpwrorji4thpga 18 31 , , , work_y6xvhkczvjdslpwrorji4thpga 18 32 and and CC work_y6xvhkczvjdslpwrorji4thpga 18 33 fibrosis fibrosis NN work_y6xvhkczvjdslpwrorji4thpga 18 34 . . . work_y6xvhkczvjdslpwrorji4thpga 19 1 This this DT work_y6xvhkczvjdslpwrorji4thpga 19 2 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 19 3 phenotype phenotype NN work_y6xvhkczvjdslpwrorji4thpga 19 4 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 19 5 very very RB work_y6xvhkczvjdslpwrorji4thpga 19 6 similar similar JJ work_y6xvhkczvjdslpwrorji4thpga 19 7 to to IN work_y6xvhkczvjdslpwrorji4thpga 19 8 a a DT work_y6xvhkczvjdslpwrorji4thpga 19 9 subtype subtype NN work_y6xvhkczvjdslpwrorji4thpga 19 10 of of IN work_y6xvhkczvjdslpwrorji4thpga 19 11 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 19 12 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 19 13 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 19 14 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 19 15 , , , work_y6xvhkczvjdslpwrorji4thpga 19 16 hallmarked hallmarke VBN work_y6xvhkczvjdslpwrorji4thpga 19 17 by by IN work_y6xvhkczvjdslpwrorji4thpga 19 18 a a DT work_y6xvhkczvjdslpwrorji4thpga 19 19 high high JJ work_y6xvhkczvjdslpwrorji4thpga 19 20 serum serum NN work_y6xvhkczvjdslpwrorji4thpga 19 21 g g NN work_y6xvhkczvjdslpwrorji4thpga 19 22 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 19 23 glutamyltransfer- glutamyltransfer- NN work_y6xvhkczvjdslpwrorji4thpga 19 24 ase ase NN work_y6xvhkczvjdslpwrorji4thpga 19 25 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 19 26 g g NNP work_y6xvhkczvjdslpwrorji4thpga 19 27 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 19 28 GT GT NNP work_y6xvhkczvjdslpwrorji4thpga 19 29 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 19 30 activity activity NN work_y6xvhkczvjdslpwrorji4thpga 19 31 . . . work_y6xvhkczvjdslpwrorji4thpga 20 1 We -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 20 2 report report VBP work_y6xvhkczvjdslpwrorji4thpga 20 3 immunohistochemistry immunohistochemistry NN work_y6xvhkczvjdslpwrorji4thpga 20 4 for for IN work_y6xvhkczvjdslpwrorji4thpga 20 5 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 20 6 P P NNP work_y6xvhkczvjdslpwrorji4thpga 20 7 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 20 8 gp gp NNP work_y6xvhkczvjdslpwrorji4thpga 20 9 , , , work_y6xvhkczvjdslpwrorji4thpga 20 10 reverse reverse JJ work_y6xvhkczvjdslpwrorji4thpga 20 11 transcription transcription NN work_y6xvhkczvjdslpwrorji4thpga 20 12 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 20 13 coupled couple VBN work_y6xvhkczvjdslpwrorji4thpga 20 14 PCR PCR NNP work_y6xvhkczvjdslpwrorji4thpga 20 15 sequence sequence NN work_y6xvhkczvjdslpwrorji4thpga 20 16 analysis analysis NN work_y6xvhkczvjdslpwrorji4thpga 20 17 , , , work_y6xvhkczvjdslpwrorji4thpga 20 18 and and CC work_y6xvhkczvjdslpwrorji4thpga 20 19 genomic genomic JJ work_y6xvhkczvjdslpwrorji4thpga 20 20 DNA dna NN work_y6xvhkczvjdslpwrorji4thpga 20 21 analysis analysis NN work_y6xvhkczvjdslpwrorji4thpga 20 22 of of IN work_y6xvhkczvjdslpwrorji4thpga 20 23 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 20 24 from from IN work_y6xvhkczvjdslpwrorji4thpga 20 25 two two CD work_y6xvhkczvjdslpwrorji4thpga 20 26 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 20 27 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 20 28 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 20 29 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 20 30 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 20 31 with with IN work_y6xvhkczvjdslpwrorji4thpga 20 32 high high JJ work_y6xvhkczvjdslpwrorji4thpga 20 33 serum serum NN work_y6xvhkczvjdslpwrorji4thpga 20 34 g g NNP work_y6xvhkczvjdslpwrorji4thpga 20 35 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 20 36 GT GT NNP work_y6xvhkczvjdslpwrorji4thpga 20 37 . . . work_y6xvhkczvjdslpwrorji4thpga 21 1 Canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 21 2 staining stain VBG work_y6xvhkczvjdslpwrorji4thpga 21 3 for for IN work_y6xvhkczvjdslpwrorji4thpga 21 4 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 21 5 P P NNP work_y6xvhkczvjdslpwrorji4thpga 21 6 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 21 7 gp gp NNP work_y6xvhkczvjdslpwrorji4thpga 21 8 was be VBD work_y6xvhkczvjdslpwrorji4thpga 21 9 negative negative JJ work_y6xvhkczvjdslpwrorji4thpga 21 10 in in IN work_y6xvhkczvjdslpwrorji4thpga 21 11 liver liver JJ work_y6xvhkczvjdslpwrorji4thpga 21 12 tissue tissue NN work_y6xvhkczvjdslpwrorji4thpga 21 13 of of IN work_y6xvhkczvjdslpwrorji4thpga 21 14 both both DT work_y6xvhkczvjdslpwrorji4thpga 21 15 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 21 16 . . . work_y6xvhkczvjdslpwrorji4thpga 22 1 Reverse reverse VB work_y6xvhkczvjdslpwrorji4thpga 22 2 transcrip- transcrip- NNS work_y6xvhkczvjdslpwrorji4thpga 22 3 tion tion NN work_y6xvhkczvjdslpwrorji4thpga 22 4 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 22 5 coupled couple VBN work_y6xvhkczvjdslpwrorji4thpga 22 6 PCR PCR NNP work_y6xvhkczvjdslpwrorji4thpga 22 7 sequencing sequencing NN work_y6xvhkczvjdslpwrorji4thpga 22 8 of of IN work_y6xvhkczvjdslpwrorji4thpga 22 9 the the DT work_y6xvhkczvjdslpwrorji4thpga 22 10 first first JJ work_y6xvhkczvjdslpwrorji4thpga 22 11 patient patient NN work_y6xvhkczvjdslpwrorji4thpga 22 12 ’s ’s POS work_y6xvhkczvjdslpwrorji4thpga 22 13 sequence sequence NN work_y6xvhkczvjdslpwrorji4thpga 22 14 demonstrated demonstrate VBD work_y6xvhkczvjdslpwrorji4thpga 22 15 a a DT work_y6xvhkczvjdslpwrorji4thpga 22 16 homozygous homozygous JJ work_y6xvhkczvjdslpwrorji4thpga 22 17 7-bp 7-bp CD work_y6xvhkczvjdslpwrorji4thpga 22 18 deletion deletion NN work_y6xvhkczvjdslpwrorji4thpga 22 19 , , , work_y6xvhkczvjdslpwrorji4thpga 22 20 starting start VBG work_y6xvhkczvjdslpwrorji4thpga 22 21 at at IN work_y6xvhkczvjdslpwrorji4thpga 22 22 codon codon NNP work_y6xvhkczvjdslpwrorji4thpga 22 23 132 132 CD work_y6xvhkczvjdslpwrorji4thpga 22 24 , , , work_y6xvhkczvjdslpwrorji4thpga 22 25 which which WDT work_y6xvhkczvjdslpwrorji4thpga 22 26 results result VBZ work_y6xvhkczvjdslpwrorji4thpga 22 27 in in IN work_y6xvhkczvjdslpwrorji4thpga 22 28 a a DT work_y6xvhkczvjdslpwrorji4thpga 22 29 frameshift frameshift NN work_y6xvhkczvjdslpwrorji4thpga 22 30 and and CC work_y6xvhkczvjdslpwrorji4thpga 22 31 introduces introduce VBZ work_y6xvhkczvjdslpwrorji4thpga 22 32 a a DT work_y6xvhkczvjdslpwrorji4thpga 22 33 stop stop NN work_y6xvhkczvjdslpwrorji4thpga 22 34 codon codon NNP work_y6xvhkczvjdslpwrorji4thpga 22 35 29 29 CD work_y6xvhkczvjdslpwrorji4thpga 22 36 codons codon NNS work_y6xvhkczvjdslpwrorji4thpga 22 37 downstream downstream JJ work_y6xvhkczvjdslpwrorji4thpga 22 38 . . . work_y6xvhkczvjdslpwrorji4thpga 23 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 23 2 second second JJ work_y6xvhkczvjdslpwrorji4thpga 23 3 patient patient NN work_y6xvhkczvjdslpwrorji4thpga 23 4 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 23 5 homozygous homozygous JJ work_y6xvhkczvjdslpwrorji4thpga 23 6 for for IN work_y6xvhkczvjdslpwrorji4thpga 23 7 a a DT work_y6xvhkczvjdslpwrorji4thpga 23 8 nonsense nonsense NN work_y6xvhkczvjdslpwrorji4thpga 23 9 mutation mutation NN work_y6xvhkczvjdslpwrorji4thpga 23 10 in in IN work_y6xvhkczvjdslpwrorji4thpga 23 11 codon codon NNP work_y6xvhkczvjdslpwrorji4thpga 23 12 957 957 CD work_y6xvhkczvjdslpwrorji4thpga 23 13 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 23 14 C C NNP work_y6xvhkczvjdslpwrorji4thpga 23 15 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 23 16 T T NNP work_y6xvhkczvjdslpwrorji4thpga 23 17 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 23 18 that that WDT work_y6xvhkczvjdslpwrorji4thpga 23 19 introduces introduce VBZ work_y6xvhkczvjdslpwrorji4thpga 23 20 a a DT work_y6xvhkczvjdslpwrorji4thpga 23 21 stop stop NN work_y6xvhkczvjdslpwrorji4thpga 23 22 codon codon NN work_y6xvhkczvjdslpwrorji4thpga 23 23 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 23 24 TGA TGA NNP work_y6xvhkczvjdslpwrorji4thpga 23 25 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 23 26 . . . work_y6xvhkczvjdslpwrorji4thpga 24 1 Our -PRON- PRP$ work_y6xvhkczvjdslpwrorji4thpga 24 2 results result NNS work_y6xvhkczvjdslpwrorji4thpga 24 3 demon- demon- NN work_y6xvhkczvjdslpwrorji4thpga 24 4 strate strate NN work_y6xvhkczvjdslpwrorji4thpga 24 5 that that WDT work_y6xvhkczvjdslpwrorji4thpga 24 6 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 24 7 in in IN work_y6xvhkczvjdslpwrorji4thpga 24 8 the the DT work_y6xvhkczvjdslpwrorji4thpga 24 9 human human JJ work_y6xvhkczvjdslpwrorji4thpga 24 10 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 24 11 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 24 12 lead lead NN work_y6xvhkczvjdslpwrorji4thpga 24 13 to to IN work_y6xvhkczvjdslpwrorji4thpga 24 14 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 24 15 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 24 16 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 24 17 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 24 18 with with IN work_y6xvhkczvjdslpwrorji4thpga 24 19 high high JJ work_y6xvhkczvjdslpwrorji4thpga 24 20 se- se- NN work_y6xvhkczvjdslpwrorji4thpga 24 21 rum rum NN work_y6xvhkczvjdslpwrorji4thpga 24 22 g g NNP work_y6xvhkczvjdslpwrorji4thpga 24 23 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 24 24 GT GT NNP work_y6xvhkczvjdslpwrorji4thpga 24 25 . . . work_y6xvhkczvjdslpwrorji4thpga 25 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 25 2 histopathological histopathological JJ work_y6xvhkczvjdslpwrorji4thpga 25 3 picture picture NN work_y6xvhkczvjdslpwrorji4thpga 25 4 in in IN work_y6xvhkczvjdslpwrorji4thpga 25 5 these these DT work_y6xvhkczvjdslpwrorji4thpga 25 6 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 25 7 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 25 8 very very RB work_y6xvhkczvjdslpwrorji4thpga 25 9 similar similar JJ work_y6xvhkczvjdslpwrorji4thpga 25 10 to to IN work_y6xvhkczvjdslpwrorji4thpga 25 11 that that DT work_y6xvhkczvjdslpwrorji4thpga 25 12 in in IN work_y6xvhkczvjdslpwrorji4thpga 25 13 the the DT work_y6xvhkczvjdslpwrorji4thpga 25 14 corresponding corresponding JJ work_y6xvhkczvjdslpwrorji4thpga 25 15 mdr2 mdr2 NN work_y6xvhkczvjdslpwrorji4thpga 25 16 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 25 17 2/2 2/2 LS work_y6xvhkczvjdslpwrorji4thpga 25 18 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 25 19 mouse mouse NN work_y6xvhkczvjdslpwrorji4thpga 25 20 , , , work_y6xvhkczvjdslpwrorji4thpga 25 21 in in IN work_y6xvhkczvjdslpwrorji4thpga 25 22 which which WDT work_y6xvhkczvjdslpwrorji4thpga 25 23 mdr2 mdr2 NNP work_y6xvhkczvjdslpwrorji4thpga 25 24 P P NNP work_y6xvhkczvjdslpwrorji4thpga 25 25 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 25 26 gp gp NNP work_y6xvhkczvjdslpwrorji4thpga 25 27 deficiency deficiency NN work_y6xvhkczvjdslpwrorji4thpga 25 28 induces induce VBZ work_y6xvhkczvjdslpwrorji4thpga 25 29 complete complete JJ work_y6xvhkczvjdslpwrorji4thpga 25 30 absence absence NN work_y6xvhkczvjdslpwrorji4thpga 25 31 of of IN work_y6xvhkczvjdslpwrorji4thpga 25 32 phospholipid phospholipid NN work_y6xvhkczvjdslpwrorji4thpga 25 33 in in IN work_y6xvhkczvjdslpwrorji4thpga 25 34 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 25 35 . . . work_y6xvhkczvjdslpwrorji4thpga 26 1 COMMENTS comment NNS work_y6xvhkczvjdslpwrorji4thpga 26 2 Progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 26 3 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 26 4 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 26 5 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 26 6 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 26 7 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 26 8 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 26 9 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 26 10 the the DT work_y6xvhkczvjdslpwrorji4thpga 26 11 name name NN work_y6xvhkczvjdslpwrorji4thpga 26 12 given give VBN work_y6xvhkczvjdslpwrorji4thpga 26 13 to to IN work_y6xvhkczvjdslpwrorji4thpga 26 14 a a DT work_y6xvhkczvjdslpwrorji4thpga 26 15 group group NN work_y6xvhkczvjdslpwrorji4thpga 26 16 of of IN work_y6xvhkczvjdslpwrorji4thpga 26 17 autosomal autosomal JJ work_y6xvhkczvjdslpwrorji4thpga 26 18 recessive recessive JJ work_y6xvhkczvjdslpwrorji4thpga 26 19 disorders disorder NNS work_y6xvhkczvjdslpwrorji4thpga 26 20 in in IN work_y6xvhkczvjdslpwrorji4thpga 26 21 which which WDT work_y6xvhkczvjdslpwrorji4thpga 26 22 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 26 23 develops develop VBZ work_y6xvhkczvjdslpwrorji4thpga 26 24 in in IN work_y6xvhkczvjdslpwrorji4thpga 26 25 early early JJ work_y6xvhkczvjdslpwrorji4thpga 26 26 infancy infancy NN work_y6xvhkczvjdslpwrorji4thpga 26 27 and and CC work_y6xvhkczvjdslpwrorji4thpga 26 28 progresses progress VBZ work_y6xvhkczvjdslpwrorji4thpga 26 29 to to IN work_y6xvhkczvjdslpwrorji4thpga 26 30 end end VB work_y6xvhkczvjdslpwrorji4thpga 26 31 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 26 32 stage stage NN work_y6xvhkczvjdslpwrorji4thpga 26 33 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 26 34 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 26 35 before before IN work_y6xvhkczvjdslpwrorji4thpga 26 36 adulthood.1,2 adulthood.1,2 `` work_y6xvhkczvjdslpwrorji4thpga 26 37 Patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 26 38 with with IN work_y6xvhkczvjdslpwrorji4thpga 26 39 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 26 40 type type NN work_y6xvhkczvjdslpwrorji4thpga 26 41 1 1 CD work_y6xvhkczvjdslpwrorji4thpga 26 42 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 26 43 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 26 44 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 26 45 , , , work_y6xvhkczvjdslpwrorji4thpga 26 46 or or CC work_y6xvhkczvjdslpwrorji4thpga 26 47 Byler Byler NNP work_y6xvhkczvjdslpwrorji4thpga 26 48 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 26 49 , , , work_y6xvhkczvjdslpwrorji4thpga 26 50 named name VBN work_y6xvhkczvjdslpwrorji4thpga 26 51 for for IN work_y6xvhkczvjdslpwrorji4thpga 26 52 the the DT work_y6xvhkczvjdslpwrorji4thpga 26 53 extended extended JJ work_y6xvhkczvjdslpwrorji4thpga 26 54 Amish Amish NNP work_y6xvhkczvjdslpwrorji4thpga 26 55 kindred kindre VBN work_y6xvhkczvjdslpwrorji4thpga 26 56 in in IN work_y6xvhkczvjdslpwrorji4thpga 26 57 which which WDT work_y6xvhkczvjdslpwrorji4thpga 26 58 it -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 26 59 was be VBD work_y6xvhkczvjdslpwrorji4thpga 26 60 first first RB work_y6xvhkczvjdslpwrorji4thpga 26 61 described,3 described,3 NNS work_y6xvhkczvjdslpwrorji4thpga 26 62 exhibit exhibit NN work_y6xvhkczvjdslpwrorji4thpga 26 63 disproportionately disproportionately RB work_y6xvhkczvjdslpwrorji4thpga 26 64 low low JJ work_y6xvhkczvjdslpwrorji4thpga 26 65 serum serum NN work_y6xvhkczvjdslpwrorji4thpga 26 66 g g NNP work_y6xvhkczvjdslpwrorji4thpga 26 67 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 26 68 glutamyl glutamyl NNP work_y6xvhkczvjdslpwrorji4thpga 26 69 transpepti- transpepti- NNP work_y6xvhkczvjdslpwrorji4thpga 26 70 dase dase NNP work_y6xvhkczvjdslpwrorji4thpga 26 71 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 26 72 GGTP GGTP NNP work_y6xvhkczvjdslpwrorji4thpga 26 73 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 26 74 and and CC work_y6xvhkczvjdslpwrorji4thpga 26 75 cholesterol cholesterol NN work_y6xvhkczvjdslpwrorji4thpga 26 76 levels level NNS work_y6xvhkczvjdslpwrorji4thpga 26 77 for for IN work_y6xvhkczvjdslpwrorji4thpga 26 78 the the DT work_y6xvhkczvjdslpwrorji4thpga 26 79 degree degree NN work_y6xvhkczvjdslpwrorji4thpga 26 80 of of IN work_y6xvhkczvjdslpwrorji4thpga 26 81 cholesta- cholesta- NNP work_y6xvhkczvjdslpwrorji4thpga 26 82 sis sis NNP work_y6xvhkczvjdslpwrorji4thpga 26 83 , , , work_y6xvhkczvjdslpwrorji4thpga 26 84 along along IN work_y6xvhkczvjdslpwrorji4thpga 26 85 with with IN work_y6xvhkczvjdslpwrorji4thpga 26 86 a a DT work_y6xvhkczvjdslpwrorji4thpga 26 87 bland bland JJ work_y6xvhkczvjdslpwrorji4thpga 26 88 intracanalicular intracanalicular JJ work_y6xvhkczvjdslpwrorji4thpga 26 89 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 26 90 by by IN work_y6xvhkczvjdslpwrorji4thpga 26 91 light light NN work_y6xvhkczvjdslpwrorji4thpga 26 92 microscopy microscopy JJ work_y6xvhkczvjdslpwrorji4thpga 26 93 and and CC work_y6xvhkczvjdslpwrorji4thpga 26 94 coarsely coarsely RB work_y6xvhkczvjdslpwrorji4thpga 26 95 granular granular JJ work_y6xvhkczvjdslpwrorji4thpga 26 96 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 26 97 on on IN work_y6xvhkczvjdslpwrorji4thpga 26 98 transmission transmission NN work_y6xvhkczvjdslpwrorji4thpga 26 99 elec- elec- . work_y6xvhkczvjdslpwrorji4thpga 26 100 tron tron NNP work_y6xvhkczvjdslpwrorji4thpga 26 101 microscopy.4 microscopy.4 NNP work_y6xvhkczvjdslpwrorji4thpga 26 102 By by IN work_y6xvhkczvjdslpwrorji4thpga 26 103 using use VBG work_y6xvhkczvjdslpwrorji4thpga 26 104 material material NN work_y6xvhkczvjdslpwrorji4thpga 26 105 from from IN work_y6xvhkczvjdslpwrorji4thpga 26 106 the the DT work_y6xvhkczvjdslpwrorji4thpga 26 107 original original JJ work_y6xvhkczvjdslpwrorji4thpga 26 108 Byler Byler NNP work_y6xvhkczvjdslpwrorji4thpga 26 109 kindred kindred NNP work_y6xvhkczvjdslpwrorji4thpga 26 110 , , , work_y6xvhkczvjdslpwrorji4thpga 26 111 the the DT work_y6xvhkczvjdslpwrorji4thpga 26 112 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 26 113 responsible responsible JJ work_y6xvhkczvjdslpwrorji4thpga 26 114 for for IN work_y6xvhkczvjdslpwrorji4thpga 26 115 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 26 116 was be VBD work_y6xvhkczvjdslpwrorji4thpga 26 117 mapped map VBN work_y6xvhkczvjdslpwrorji4thpga 26 118 to to TO work_y6xvhkczvjdslpwrorji4thpga 26 119 chromosome chromosome VB work_y6xvhkczvjdslpwrorji4thpga 26 120 18q21 18q21 CD work_y6xvhkczvjdslpwrorji4thpga 26 121 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 26 122 22.5 22.5 CD work_y6xvhkczvjdslpwrorji4thpga 26 123 This this DT work_y6xvhkczvjdslpwrorji4thpga 26 124 same same JJ work_y6xvhkczvjdslpwrorji4thpga 26 125 region region NN work_y6xvhkczvjdslpwrorji4thpga 26 126 had have VBD work_y6xvhkczvjdslpwrorji4thpga 26 127 been be VBN work_y6xvhkczvjdslpwrorji4thpga 26 128 linked link VBN work_y6xvhkczvjdslpwrorji4thpga 26 129 earlier early RBR work_y6xvhkczvjdslpwrorji4thpga 26 130 to to TO work_y6xvhkczvjdslpwrorji4thpga 26 131 benign benign VB work_y6xvhkczvjdslpwrorji4thpga 26 132 recurrent recurrent JJ work_y6xvhkczvjdslpwrorji4thpga 26 133 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 26 134 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 26 135 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 26 136 BRIC BRIC NNP work_y6xvhkczvjdslpwrorji4thpga 26 137 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 26 138 , , , work_y6xvhkczvjdslpwrorji4thpga 26 139 a a DT work_y6xvhkczvjdslpwrorji4thpga 26 140 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 26 141 characterized characterize VBN work_y6xvhkczvjdslpwrorji4thpga 26 142 by by IN work_y6xvhkczvjdslpwrorji4thpga 26 143 episodic episodic JJ work_y6xvhkczvjdslpwrorji4thpga 26 144 attacks attack NNS work_y6xvhkczvjdslpwrorji4thpga 26 145 of of IN work_y6xvhkczvjdslpwrorji4thpga 26 146 jaundice jaundice NN work_y6xvhkczvjdslpwrorji4thpga 26 147 and and CC work_y6xvhkczvjdslpwrorji4thpga 26 148 pruritus pruritus NN work_y6xvhkczvjdslpwrorji4thpga 26 149 but but CC work_y6xvhkczvjdslpwrorji4thpga 26 150 without without IN work_y6xvhkczvjdslpwrorji4thpga 26 151 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 26 152 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 26 153 disease6 disease6 NN work_y6xvhkczvjdslpwrorji4thpga 26 154 ; ; : work_y6xvhkczvjdslpwrorji4thpga 26 155 this this DT work_y6xvhkczvjdslpwrorji4thpga 26 156 suggested suggest VBD work_y6xvhkczvjdslpwrorji4thpga 26 157 that that IN work_y6xvhkczvjdslpwrorji4thpga 26 158 the the DT work_y6xvhkczvjdslpwrorji4thpga 26 159 two two CD work_y6xvhkczvjdslpwrorji4thpga 26 160 phenotypes phenotype NNS work_y6xvhkczvjdslpwrorji4thpga 26 161 are be VBP work_y6xvhkczvjdslpwrorji4thpga 26 162 allelic allelic JJ work_y6xvhkczvjdslpwrorji4thpga 26 163 variants variant NNS work_y6xvhkczvjdslpwrorji4thpga 26 164 of of IN work_y6xvhkczvjdslpwrorji4thpga 26 165 the the DT work_y6xvhkczvjdslpwrorji4thpga 26 166 same same JJ work_y6xvhkczvjdslpwrorji4thpga 26 167 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 26 168 . . . work_y6xvhkczvjdslpwrorji4thpga 27 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 27 2 contrast contrast NN work_y6xvhkczvjdslpwrorji4thpga 27 3 , , , work_y6xvhkczvjdslpwrorji4thpga 27 4 there there EX work_y6xvhkczvjdslpwrorji4thpga 27 5 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 27 6 a a DT work_y6xvhkczvjdslpwrorji4thpga 27 7 second second JJ work_y6xvhkczvjdslpwrorji4thpga 27 8 group group NN work_y6xvhkczvjdslpwrorji4thpga 27 9 of of IN work_y6xvhkczvjdslpwrorji4thpga 27 10 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 27 11 with with IN work_y6xvhkczvjdslpwrorji4thpga 27 12 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 27 13 who who WP work_y6xvhkczvjdslpwrorji4thpga 27 14 exhibit exhibit VBP work_y6xvhkczvjdslpwrorji4thpga 27 15 high high JJ work_y6xvhkczvjdslpwrorji4thpga 27 16 serum serum NN work_y6xvhkczvjdslpwrorji4thpga 27 17 GGTP ggtp NN work_y6xvhkczvjdslpwrorji4thpga 27 18 levels level NNS work_y6xvhkczvjdslpwrorji4thpga 27 19 and and CC work_y6xvhkczvjdslpwrorji4thpga 27 20 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 27 21 duct duct NN work_y6xvhkczvjdslpwrorji4thpga 27 22 proliferation proliferation NN work_y6xvhkczvjdslpwrorji4thpga 27 23 along along IN work_y6xvhkczvjdslpwrorji4thpga 27 24 with with IN work_y6xvhkczvjdslpwrorji4thpga 27 25 portal portal JJ work_y6xvhkczvjdslpwrorji4thpga 27 26 inflammatory inflammatory JJ work_y6xvhkczvjdslpwrorji4thpga 27 27 infiltrates infiltrate NNS work_y6xvhkczvjdslpwrorji4thpga 27 28 on on IN work_y6xvhkczvjdslpwrorji4thpga 27 29 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 27 30 histology.7 histology.7 PDT work_y6xvhkczvjdslpwrorji4thpga 27 31 These these DT work_y6xvhkczvjdslpwrorji4thpga 27 32 changes change NNS work_y6xvhkczvjdslpwrorji4thpga 27 33 resemble resemble VBP work_y6xvhkczvjdslpwrorji4thpga 27 34 those those DT work_y6xvhkczvjdslpwrorji4thpga 27 35 that that WDT work_y6xvhkczvjdslpwrorji4thpga 27 36 have have VBP work_y6xvhkczvjdslpwrorji4thpga 27 37 been be VBN work_y6xvhkczvjdslpwrorji4thpga 27 38 observed observe VBN work_y6xvhkczvjdslpwrorji4thpga 27 39 following follow VBG work_y6xvhkczvjdslpwrorji4thpga 27 40 disruption disruption NN work_y6xvhkczvjdslpwrorji4thpga 27 41 of of IN work_y6xvhkczvjdslpwrorji4thpga 27 42 the the DT work_y6xvhkczvjdslpwrorji4thpga 27 43 mdr2 mdr2 NNP work_y6xvhkczvjdslpwrorji4thpga 27 44 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 27 45 , , , work_y6xvhkczvjdslpwrorji4thpga 27 46 the the DT work_y6xvhkczvjdslpwrorji4thpga 27 47 mouse mouse NN work_y6xvhkczvjdslpwrorji4thpga 27 48 homolog homolog NNP work_y6xvhkczvjdslpwrorji4thpga 27 49 of of IN work_y6xvhkczvjdslpwrorji4thpga 27 50 human human NNP work_y6xvhkczvjdslpwrorji4thpga 27 51 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 27 52 , , , work_y6xvhkczvjdslpwrorji4thpga 27 53 which which WDT work_y6xvhkczvjdslpwrorji4thpga 27 54 encodes encode VBZ work_y6xvhkczvjdslpwrorji4thpga 27 55 a a DT work_y6xvhkczvjdslpwrorji4thpga 27 56 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 27 57 P P NNP work_y6xvhkczvjdslpwrorji4thpga 27 58 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 27 59 glycoprotein glycoprotein NNP work_y6xvhkczvjdslpwrorji4thpga 27 60 required require VBN work_y6xvhkczvjdslpwrorji4thpga 27 61 for for IN work_y6xvhkczvjdslpwrorji4thpga 27 62 biliary biliary JJ work_y6xvhkczvjdslpwrorji4thpga 27 63 phospholipid phospholipid NN work_y6xvhkczvjdslpwrorji4thpga 27 64 secretion.8 secretion.8 VBN work_y6xvhkczvjdslpwrorji4thpga 27 65 In in IN work_y6xvhkczvjdslpwrorji4thpga 27 66 one one CD work_y6xvhkczvjdslpwrorji4thpga 27 67 patient patient NN work_y6xvhkczvjdslpwrorji4thpga 27 68 with with IN work_y6xvhkczvjdslpwrorji4thpga 27 69 this this DT work_y6xvhkczvjdslpwrorji4thpga 27 70 second second JJ work_y6xvhkczvjdslpwrorji4thpga 27 71 type type NN work_y6xvhkczvjdslpwrorji4thpga 27 72 of of IN work_y6xvhkczvjdslpwrorji4thpga 27 73 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 27 74 , , , work_y6xvhkczvjdslpwrorji4thpga 27 75 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 27 76 messenger messenger NN work_y6xvhkczvjdslpwrorji4thpga 27 77 RNA RNA NNP work_y6xvhkczvjdslpwrorji4thpga 27 78 was be VBD work_y6xvhkczvjdslpwrorji4thpga 27 79 undetectable undetectable JJ work_y6xvhkczvjdslpwrorji4thpga 27 80 and and CC work_y6xvhkczvjdslpwrorji4thpga 27 81 in in IN work_y6xvhkczvjdslpwrorji4thpga 27 82 another another DT work_y6xvhkczvjdslpwrorji4thpga 27 83 phospho- phospho- JJ work_y6xvhkczvjdslpwrorji4thpga 27 84 lipid lipid NN work_y6xvhkczvjdslpwrorji4thpga 27 85 in in IN work_y6xvhkczvjdslpwrorji4thpga 27 86 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 27 87 was be VBD work_y6xvhkczvjdslpwrorji4thpga 27 88 markedly markedly RB work_y6xvhkczvjdslpwrorji4thpga 27 89 reduced.9 reduced.9 CD work_y6xvhkczvjdslpwrorji4thpga 27 90 The the DT work_y6xvhkczvjdslpwrorji4thpga 27 91 biochemical biochemical JJ work_y6xvhkczvjdslpwrorji4thpga 27 92 features feature NNS work_y6xvhkczvjdslpwrorji4thpga 27 93 of of IN work_y6xvhkczvjdslpwrorji4thpga 27 94 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 27 95 had have VBD work_y6xvhkczvjdslpwrorji4thpga 27 96 been be VBN work_y6xvhkczvjdslpwrorji4thpga 27 97 previously previously RB work_y6xvhkczvjdslpwrorji4thpga 27 98 linked link VBN work_y6xvhkczvjdslpwrorji4thpga 27 99 to to IN work_y6xvhkczvjdslpwrorji4thpga 27 100 defects defect NNS work_y6xvhkczvjdslpwrorji4thpga 27 101 in in IN work_y6xvhkczvjdslpwrorji4thpga 27 102 either either DT work_y6xvhkczvjdslpwrorji4thpga 27 103 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 27 104 salt salt NN work_y6xvhkczvjdslpwrorji4thpga 27 105 synthesis10 synthesis10 NNS work_y6xvhkczvjdslpwrorji4thpga 27 106 or or CC work_y6xvhkczvjdslpwrorji4thpga 27 107 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 27 108 salt salt NN work_y6xvhkczvjdslpwrorji4thpga 27 109 secretion.11 secretion.11 NNP work_y6xvhkczvjdslpwrorji4thpga 27 110 Total total JJ work_y6xvhkczvjdslpwrorji4thpga 27 111 biliary biliary JJ work_y6xvhkczvjdslpwrorji4thpga 27 112 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 27 113 acids acid NNS work_y6xvhkczvjdslpwrorji4thpga 27 114 were be VBD work_y6xvhkczvjdslpwrorji4thpga 27 115 markedly markedly RB work_y6xvhkczvjdslpwrorji4thpga 27 116 reduced reduce VBN work_y6xvhkczvjdslpwrorji4thpga 27 117 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 27 118 1.1 1.1 CD work_y6xvhkczvjdslpwrorji4thpga 27 119 6 6 CD work_y6xvhkczvjdslpwrorji4thpga 27 120 1.4 1.4 CD work_y6xvhkczvjdslpwrorji4thpga 27 121 mmol mmol NN work_y6xvhkczvjdslpwrorji4thpga 27 122 / / SYM work_y6xvhkczvjdslpwrorji4thpga 27 123 L L NNP work_y6xvhkczvjdslpwrorji4thpga 27 124 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 27 125 in in IN work_y6xvhkczvjdslpwrorji4thpga 27 126 seven seven CD work_y6xvhkczvjdslpwrorji4thpga 27 127 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 27 128 with with IN work_y6xvhkczvjdslpwrorji4thpga 27 129 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 27 130 compared compare VBN work_y6xvhkczvjdslpwrorji4thpga 27 131 with with IN work_y6xvhkczvjdslpwrorji4thpga 27 132 values value NNS work_y6xvhkczvjdslpwrorji4thpga 27 133 in in IN work_y6xvhkczvjdslpwrorji4thpga 27 134 eight eight CD work_y6xvhkczvjdslpwrorji4thpga 27 135 control control NN work_y6xvhkczvjdslpwrorji4thpga 27 136 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 27 137 with with IN work_y6xvhkczvjdslpwrorji4thpga 27 138 other other JJ work_y6xvhkczvjdslpwrorji4thpga 27 139 cholestatic cholestatic JJ work_y6xvhkczvjdslpwrorji4thpga 27 140 diseases disease NNS work_y6xvhkczvjdslpwrorji4thpga 27 141 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 27 142 88.9 88.9 CD work_y6xvhkczvjdslpwrorji4thpga 27 143 6 6 CD work_y6xvhkczvjdslpwrorji4thpga 27 144 83.2 83.2 CD work_y6xvhkczvjdslpwrorji4thpga 27 145 mmol mmol NN work_y6xvhkczvjdslpwrorji4thpga 27 146 / / SYM work_y6xvhkczvjdslpwrorji4thpga 27 147 L).11 L).11 NNP work_y6xvhkczvjdslpwrorji4thpga 27 148 Strikingly strikingly RB work_y6xvhkczvjdslpwrorji4thpga 27 149 low low JJ work_y6xvhkczvjdslpwrorji4thpga 27 150 percentages percentage NNS work_y6xvhkczvjdslpwrorji4thpga 27 151 of of IN work_y6xvhkczvjdslpwrorji4thpga 27 152 chenodeoxycholic chenodeoxycholic NN work_y6xvhkczvjdslpwrorji4thpga 27 153 acid acid NN work_y6xvhkczvjdslpwrorji4thpga 27 154 were be VBD work_y6xvhkczvjdslpwrorji4thpga 27 155 observed observe VBN work_y6xvhkczvjdslpwrorji4thpga 27 156 in in IN work_y6xvhkczvjdslpwrorji4thpga 27 157 gallbladder gallbladder NN work_y6xvhkczvjdslpwrorji4thpga 27 158 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 27 159 from from IN work_y6xvhkczvjdslpwrorji4thpga 27 160 the the DT work_y6xvhkczvjdslpwrorji4thpga 27 161 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 27 162 patients.11 patients.11 NNP work_y6xvhkczvjdslpwrorji4thpga 27 163 In in IN work_y6xvhkczvjdslpwrorji4thpga 27 164 this this DT work_y6xvhkczvjdslpwrorji4thpga 27 165 context context NN work_y6xvhkczvjdslpwrorji4thpga 27 166 , , , work_y6xvhkczvjdslpwrorji4thpga 27 167 two two CD work_y6xvhkczvjdslpwrorji4thpga 27 168 independent independent JJ work_y6xvhkczvjdslpwrorji4thpga 27 169 groups group NNS work_y6xvhkczvjdslpwrorji4thpga 27 170 have have VBP work_y6xvhkczvjdslpwrorji4thpga 27 171 now now RB work_y6xvhkczvjdslpwrorji4thpga 27 172 defined define VBN work_y6xvhkczvjdslpwrorji4thpga 27 173 the the DT work_y6xvhkczvjdslpwrorji4thpga 27 174 molecular molecular JJ work_y6xvhkczvjdslpwrorji4thpga 27 175 defects defect NNS work_y6xvhkczvjdslpwrorji4thpga 27 176 underlying underlie VBG work_y6xvhkczvjdslpwrorji4thpga 27 177 various various JJ work_y6xvhkczvjdslpwrorji4thpga 27 178 forms form NNS work_y6xvhkczvjdslpwrorji4thpga 27 179 of of IN work_y6xvhkczvjdslpwrorji4thpga 27 180 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 27 181 . . . work_y6xvhkczvjdslpwrorji4thpga 28 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 28 2 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 28 3 mutated mutate VBD work_y6xvhkczvjdslpwrorji4thpga 28 4 in in IN work_y6xvhkczvjdslpwrorji4thpga 28 5 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 28 6 and and CC work_y6xvhkczvjdslpwrorji4thpga 28 7 BRIC bric NN work_y6xvhkczvjdslpwrorji4thpga 28 8 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 28 9 , , , work_y6xvhkczvjdslpwrorji4thpga 28 10 termed term VBN work_y6xvhkczvjdslpwrorji4thpga 28 11 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 28 12 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 28 13 for for IN work_y6xvhkczvjdslpwrorji4thpga 28 14 888 888 CD work_y6xvhkczvjdslpwrorji4thpga 28 15 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 28 16 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 28 17 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 28 18 1 1 CD work_y6xvhkczvjdslpwrorji4thpga 28 19 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 28 20 , , , work_y6xvhkczvjdslpwrorji4thpga 28 21 exhibits exhibit VBZ work_y6xvhkczvjdslpwrorji4thpga 28 22 significant significant JJ work_y6xvhkczvjdslpwrorji4thpga 28 23 simi- simi- NNP work_y6xvhkczvjdslpwrorji4thpga 28 24 larity larity NN work_y6xvhkczvjdslpwrorji4thpga 28 25 to to IN work_y6xvhkczvjdslpwrorji4thpga 28 26 a a DT work_y6xvhkczvjdslpwrorji4thpga 28 27 subfamily subfamily NN work_y6xvhkczvjdslpwrorji4thpga 28 28 of of IN work_y6xvhkczvjdslpwrorji4thpga 28 29 P p NN work_y6xvhkczvjdslpwrorji4thpga 28 30 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 28 31 type type NN work_y6xvhkczvjdslpwrorji4thpga 28 32 ATPase ATPase NNP work_y6xvhkczvjdslpwrorji4thpga 28 33 genes gene NNS work_y6xvhkczvjdslpwrorji4thpga 28 34 that that WDT work_y6xvhkczvjdslpwrorji4thpga 28 35 encode encode VBP work_y6xvhkczvjdslpwrorji4thpga 28 36 putative putative JJ work_y6xvhkczvjdslpwrorji4thpga 28 37 aminophospholipid aminophospholipid NN work_y6xvhkczvjdslpwrorji4thpga 28 38 transporters.12 transporters.12 NNP work_y6xvhkczvjdslpwrorji4thpga 28 39 Five five CD work_y6xvhkczvjdslpwrorji4thpga 28 40 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 28 41 in in IN work_y6xvhkczvjdslpwrorji4thpga 28 42 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 28 43 were be VBD work_y6xvhkczvjdslpwrorji4thpga 28 44 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 28 45 in in IN work_y6xvhkczvjdslpwrorji4thpga 28 46 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 28 47 with with IN work_y6xvhkczvjdslpwrorji4thpga 28 48 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 28 49 , , , work_y6xvhkczvjdslpwrorji4thpga 28 50 including include VBG work_y6xvhkczvjdslpwrorji4thpga 28 51 two two CD work_y6xvhkczvjdslpwrorji4thpga 28 52 missense missense NN work_y6xvhkczvjdslpwrorji4thpga 28 53 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 28 54 that that WDT work_y6xvhkczvjdslpwrorji4thpga 28 55 replace replace VBP work_y6xvhkczvjdslpwrorji4thpga 28 56 amino amino JJ work_y6xvhkczvjdslpwrorji4thpga 28 57 acids acid NNS work_y6xvhkczvjdslpwrorji4thpga 28 58 that that WDT work_y6xvhkczvjdslpwrorji4thpga 28 59 are be VBP work_y6xvhkczvjdslpwrorji4thpga 28 60 highly highly RB work_y6xvhkczvjdslpwrorji4thpga 28 61 conserved conserve VBN work_y6xvhkczvjdslpwrorji4thpga 28 62 in in IN work_y6xvhkczvjdslpwrorji4thpga 28 63 P p NN work_y6xvhkczvjdslpwrorji4thpga 28 64 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 28 65 type type NN work_y6xvhkczvjdslpwrorji4thpga 28 66 ATPases atpase NNS work_y6xvhkczvjdslpwrorji4thpga 28 67 , , , work_y6xvhkczvjdslpwrorji4thpga 28 68 suggesting suggest VBG work_y6xvhkczvjdslpwrorji4thpga 28 69 that that IN work_y6xvhkczvjdslpwrorji4thpga 28 70 these these DT work_y6xvhkczvjdslpwrorji4thpga 28 71 are be VBP work_y6xvhkczvjdslpwrorji4thpga 28 72 critical critical JJ work_y6xvhkczvjdslpwrorji4thpga 28 73 to to IN work_y6xvhkczvjdslpwrorji4thpga 28 74 normal normal JJ work_y6xvhkczvjdslpwrorji4thpga 28 75 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 28 76 structure structure NN work_y6xvhkczvjdslpwrorji4thpga 28 77 and/or and/or CC work_y6xvhkczvjdslpwrorji4thpga 28 78 function function NN work_y6xvhkczvjdslpwrorji4thpga 28 79 . . . work_y6xvhkczvjdslpwrorji4thpga 29 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 29 2 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 29 3 with with IN work_y6xvhkczvjdslpwrorji4thpga 29 4 BRIC BRIC NNP work_y6xvhkczvjdslpwrorji4thpga 29 5 , , , work_y6xvhkczvjdslpwrorji4thpga 29 6 two two CD work_y6xvhkczvjdslpwrorji4thpga 29 7 different different JJ work_y6xvhkczvjdslpwrorji4thpga 29 8 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 29 9 were be VBD work_y6xvhkczvjdslpwrorji4thpga 29 10 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 29 11 , , , work_y6xvhkczvjdslpwrorji4thpga 29 12 including include VBG work_y6xvhkczvjdslpwrorji4thpga 29 13 a a DT work_y6xvhkczvjdslpwrorji4thpga 29 14 missense missense NN work_y6xvhkczvjdslpwrorji4thpga 29 15 mutation mutation NN work_y6xvhkczvjdslpwrorji4thpga 29 16 and and CC work_y6xvhkczvjdslpwrorji4thpga 29 17 a a DT work_y6xvhkczvjdslpwrorji4thpga 29 18 small small JJ work_y6xvhkczvjdslpwrorji4thpga 29 19 deletion deletion NN work_y6xvhkczvjdslpwrorji4thpga 29 20 , , , work_y6xvhkczvjdslpwrorji4thpga 29 21 that that WDT work_y6xvhkczvjdslpwrorji4thpga 29 22 are be VBP work_y6xvhkczvjdslpwrorji4thpga 29 23 in in IN work_y6xvhkczvjdslpwrorji4thpga 29 24 less less RBR work_y6xvhkczvjdslpwrorji4thpga 29 25 highly highly RB work_y6xvhkczvjdslpwrorji4thpga 29 26 conserved conserve VBN work_y6xvhkczvjdslpwrorji4thpga 29 27 regions region NNS work_y6xvhkczvjdslpwrorji4thpga 29 28 of of IN work_y6xvhkczvjdslpwrorji4thpga 29 29 the the DT work_y6xvhkczvjdslpwrorji4thpga 29 30 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 29 31 . . . work_y6xvhkczvjdslpwrorji4thpga 30 1 This this DT work_y6xvhkczvjdslpwrorji4thpga 30 2 finding finding NN work_y6xvhkczvjdslpwrorji4thpga 30 3 provides provide VBZ work_y6xvhkczvjdslpwrorji4thpga 30 4 a a DT work_y6xvhkczvjdslpwrorji4thpga 30 5 potential potential JJ work_y6xvhkczvjdslpwrorji4thpga 30 6 explanation explanation NN work_y6xvhkczvjdslpwrorji4thpga 30 7 for for IN work_y6xvhkczvjdslpwrorji4thpga 30 8 the the DT work_y6xvhkczvjdslpwrorji4thpga 30 9 differences difference NNS work_y6xvhkczvjdslpwrorji4thpga 30 10 among among IN work_y6xvhkczvjdslpwrorji4thpga 30 11 the the DT work_y6xvhkczvjdslpwrorji4thpga 30 12 clinical clinical JJ work_y6xvhkczvjdslpwrorji4thpga 30 13 manifestations manifestation NNS work_y6xvhkczvjdslpwrorji4thpga 30 14 of of IN work_y6xvhkczvjdslpwrorji4thpga 30 15 BRIC BRIC NNP work_y6xvhkczvjdslpwrorji4thpga 30 16 and and CC work_y6xvhkczvjdslpwrorji4thpga 30 17 PFIC1 PFIC1 NNS work_y6xvhkczvjdslpwrorji4thpga 30 18 , , , work_y6xvhkczvjdslpwrorji4thpga 30 19 because because IN work_y6xvhkczvjdslpwrorji4thpga 30 20 the the DT work_y6xvhkczvjdslpwrorji4thpga 30 21 BRIC BRIC NNP work_y6xvhkczvjdslpwrorji4thpga 30 22 muta- muta- JJ work_y6xvhkczvjdslpwrorji4thpga 30 23 tions tion NNS work_y6xvhkczvjdslpwrorji4thpga 30 24 are be VBP work_y6xvhkczvjdslpwrorji4thpga 30 25 expected expect VBN work_y6xvhkczvjdslpwrorji4thpga 30 26 to to TO work_y6xvhkczvjdslpwrorji4thpga 30 27 have have VB work_y6xvhkczvjdslpwrorji4thpga 30 28 less less JJR work_y6xvhkczvjdslpwrorji4thpga 30 29 of of IN work_y6xvhkczvjdslpwrorji4thpga 30 30 an an DT work_y6xvhkczvjdslpwrorji4thpga 30 31 effect effect NN work_y6xvhkczvjdslpwrorji4thpga 30 32 on on IN work_y6xvhkczvjdslpwrorji4thpga 30 33 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 30 34 structure structure NN work_y6xvhkczvjdslpwrorji4thpga 30 35 and and CC work_y6xvhkczvjdslpwrorji4thpga 30 36 function function NN work_y6xvhkczvjdslpwrorji4thpga 30 37 . . . work_y6xvhkczvjdslpwrorji4thpga 31 1 A a DT work_y6xvhkczvjdslpwrorji4thpga 31 2 surprising surprising JJ work_y6xvhkczvjdslpwrorji4thpga 31 3 finding finding NN work_y6xvhkczvjdslpwrorji4thpga 31 4 was be VBD work_y6xvhkczvjdslpwrorji4thpga 31 5 preferential preferential JJ work_y6xvhkczvjdslpwrorji4thpga 31 6 expres- expres- XX work_y6xvhkczvjdslpwrorji4thpga 31 7 sion sion NN work_y6xvhkczvjdslpwrorji4thpga 31 8 of of IN work_y6xvhkczvjdslpwrorji4thpga 31 9 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 31 10 in in IN work_y6xvhkczvjdslpwrorji4thpga 31 11 the the DT work_y6xvhkczvjdslpwrorji4thpga 31 12 small small JJ work_y6xvhkczvjdslpwrorji4thpga 31 13 intestine intestine NN work_y6xvhkczvjdslpwrorji4thpga 31 14 , , , work_y6xvhkczvjdslpwrorji4thpga 31 15 consistent consistent JJ work_y6xvhkczvjdslpwrorji4thpga 31 16 with with IN work_y6xvhkczvjdslpwrorji4thpga 31 17 a a DT work_y6xvhkczvjdslpwrorji4thpga 31 18 role role NN work_y6xvhkczvjdslpwrorji4thpga 31 19 for for IN work_y6xvhkczvjdslpwrorji4thpga 31 20 this this DT work_y6xvhkczvjdslpwrorji4thpga 31 21 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 31 22 product product NN work_y6xvhkczvjdslpwrorji4thpga 31 23 in in IN work_y6xvhkczvjdslpwrorji4thpga 31 24 the the DT work_y6xvhkczvjdslpwrorji4thpga 31 25 intestinal intestinal JJ work_y6xvhkczvjdslpwrorji4thpga 31 26 handling handling NN work_y6xvhkczvjdslpwrorji4thpga 31 27 of of IN work_y6xvhkczvjdslpwrorji4thpga 31 28 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 31 29 acids acid NNS work_y6xvhkczvjdslpwrorji4thpga 31 30 . . . work_y6xvhkczvjdslpwrorji4thpga 32 1 Although although IN work_y6xvhkczvjdslpwrorji4thpga 32 2 malabsorption malabsorption NN work_y6xvhkczvjdslpwrorji4thpga 32 3 and and CC work_y6xvhkczvjdslpwrorji4thpga 32 4 diarrhea diarrhea NN work_y6xvhkczvjdslpwrorji4thpga 32 5 have have VBP work_y6xvhkczvjdslpwrorji4thpga 32 6 been be VBN work_y6xvhkczvjdslpwrorji4thpga 32 7 described describe VBN work_y6xvhkczvjdslpwrorji4thpga 32 8 in in IN work_y6xvhkczvjdslpwrorji4thpga 32 9 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 32 10 with with IN work_y6xvhkczvjdslpwrorji4thpga 32 11 PFIC1,3,13 pfic1,3,13 ADD work_y6xvhkczvjdslpwrorji4thpga 32 12 the the DT work_y6xvhkczvjdslpwrorji4thpga 32 13 clinical clinical JJ work_y6xvhkczvjdslpwrorji4thpga 32 14 manifestations manifestation NNS work_y6xvhkczvjdslpwrorji4thpga 32 15 of of IN work_y6xvhkczvjdslpwrorji4thpga 32 16 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 32 17 and and CC work_y6xvhkczvjdslpwrorji4thpga 32 18 BRIC BRIC NNP work_y6xvhkczvjdslpwrorji4thpga 32 19 led lead VBD work_y6xvhkczvjdslpwrorji4thpga 32 20 many many JJ work_y6xvhkczvjdslpwrorji4thpga 32 21 to to TO work_y6xvhkczvjdslpwrorji4thpga 32 22 suspect suspect VB work_y6xvhkczvjdslpwrorji4thpga 32 23 that that IN work_y6xvhkczvjdslpwrorji4thpga 32 24 the the DT work_y6xvhkczvjdslpwrorji4thpga 32 25 defect defect NN work_y6xvhkczvjdslpwrorji4thpga 32 26 underlying underlie VBG work_y6xvhkczvjdslpwrorji4thpga 32 27 these these DT work_y6xvhkczvjdslpwrorji4thpga 32 28 disorders disorder NNS work_y6xvhkczvjdslpwrorji4thpga 32 29 would would MD work_y6xvhkczvjdslpwrorji4thpga 32 30 be be VB work_y6xvhkczvjdslpwrorji4thpga 32 31 localized localize VBN work_y6xvhkczvjdslpwrorji4thpga 32 32 to to IN work_y6xvhkczvjdslpwrorji4thpga 32 33 the the DT work_y6xvhkczvjdslpwrorji4thpga 32 34 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 32 35 . . . work_y6xvhkczvjdslpwrorji4thpga 33 1 Furthermore furthermore RB work_y6xvhkczvjdslpwrorji4thpga 33 2 , , , work_y6xvhkczvjdslpwrorji4thpga 33 3 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 33 4 was be VBD work_y6xvhkczvjdslpwrorji4thpga 33 5 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 33 6 in in IN work_y6xvhkczvjdslpwrorji4thpga 33 7 a a DT work_y6xvhkczvjdslpwrorji4thpga 33 8 wide wide JJ work_y6xvhkczvjdslpwrorji4thpga 33 9 variety variety NN work_y6xvhkczvjdslpwrorji4thpga 33 10 of of IN work_y6xvhkczvjdslpwrorji4thpga 33 11 tissues tissue NNS work_y6xvhkczvjdslpwrorji4thpga 33 12 , , , work_y6xvhkczvjdslpwrorji4thpga 33 13 including include VBG work_y6xvhkczvjdslpwrorji4thpga 33 14 sites site NNS work_y6xvhkczvjdslpwrorji4thpga 33 15 not not RB work_y6xvhkczvjdslpwrorji4thpga 33 16 associated associate VBN work_y6xvhkczvjdslpwrorji4thpga 33 17 with with IN work_y6xvhkczvjdslpwrorji4thpga 33 18 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 33 19 acid acid NN work_y6xvhkczvjdslpwrorji4thpga 33 20 handling handling NN work_y6xvhkczvjdslpwrorji4thpga 33 21 , , , work_y6xvhkczvjdslpwrorji4thpga 33 22 such such JJ work_y6xvhkczvjdslpwrorji4thpga 33 23 as as IN work_y6xvhkczvjdslpwrorji4thpga 33 24 pancreas pancreas NN work_y6xvhkczvjdslpwrorji4thpga 33 25 and and CC work_y6xvhkczvjdslpwrorji4thpga 33 26 stomach stomach NN work_y6xvhkczvjdslpwrorji4thpga 33 27 . . . work_y6xvhkczvjdslpwrorji4thpga 34 1 This this DT work_y6xvhkczvjdslpwrorji4thpga 34 2 finding finding NN work_y6xvhkczvjdslpwrorji4thpga 34 3 suggests suggest VBZ work_y6xvhkczvjdslpwrorji4thpga 34 4 that that IN work_y6xvhkczvjdslpwrorji4thpga 34 5 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 34 6 may may MD work_y6xvhkczvjdslpwrorji4thpga 34 7 have have VB work_y6xvhkczvjdslpwrorji4thpga 34 8 a a DT work_y6xvhkczvjdslpwrorji4thpga 34 9 general general JJ work_y6xvhkczvjdslpwrorji4thpga 34 10 role role NN work_y6xvhkczvjdslpwrorji4thpga 34 11 in in IN work_y6xvhkczvjdslpwrorji4thpga 34 12 absorptive absorptive JJ work_y6xvhkczvjdslpwrorji4thpga 34 13 and and CC work_y6xvhkczvjdslpwrorji4thpga 34 14 secretory secretory NN work_y6xvhkczvjdslpwrorji4thpga 34 15 processes process NNS work_y6xvhkczvjdslpwrorji4thpga 34 16 . . . work_y6xvhkczvjdslpwrorji4thpga 35 1 Other other JJ work_y6xvhkczvjdslpwrorji4thpga 35 2 members member NNS work_y6xvhkczvjdslpwrorji4thpga 35 3 of of IN work_y6xvhkczvjdslpwrorji4thpga 35 4 the the DT work_y6xvhkczvjdslpwrorji4thpga 35 5 subfamily subfamily NN work_y6xvhkczvjdslpwrorji4thpga 35 6 to to TO work_y6xvhkczvjdslpwrorji4thpga 35 7 which which WDT work_y6xvhkczvjdslpwrorji4thpga 35 8 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 35 9 belongs belong NNS work_y6xvhkczvjdslpwrorji4thpga 35 10 are be VBP work_y6xvhkczvjdslpwrorji4thpga 35 11 believed believe VBN work_y6xvhkczvjdslpwrorji4thpga 35 12 to to TO work_y6xvhkczvjdslpwrorji4thpga 35 13 maintain maintain VB work_y6xvhkczvjdslpwrorji4thpga 35 14 an an DT work_y6xvhkczvjdslpwrorji4thpga 35 15 asymmetric asymmetric JJ work_y6xvhkczvjdslpwrorji4thpga 35 16 distribution distribution NN work_y6xvhkczvjdslpwrorji4thpga 35 17 of of IN work_y6xvhkczvjdslpwrorji4thpga 35 18 phospholipids phospholipid NNS work_y6xvhkczvjdslpwrorji4thpga 35 19 in in IN work_y6xvhkczvjdslpwrorji4thpga 35 20 membranes membrane NNS work_y6xvhkczvjdslpwrorji4thpga 35 21 by by IN work_y6xvhkczvjdslpwrorji4thpga 35 22 the the DT work_y6xvhkczvjdslpwrorji4thpga 35 23 transport transport NN work_y6xvhkczvjdslpwrorji4thpga 35 24 of of IN work_y6xvhkczvjdslpwrorji4thpga 35 25 aminophospholipids aminophospholipid NNS work_y6xvhkczvjdslpwrorji4thpga 35 26 from from IN work_y6xvhkczvjdslpwrorji4thpga 35 27 outer outer JJ work_y6xvhkczvjdslpwrorji4thpga 35 28 to to IN work_y6xvhkczvjdslpwrorji4thpga 35 29 inner inner JJ work_y6xvhkczvjdslpwrorji4thpga 35 30 leaflets.12 leaflets.12 NNP work_y6xvhkczvjdslpwrorji4thpga 35 31 Clearly clearly RB work_y6xvhkczvjdslpwrorji4thpga 35 32 , , , work_y6xvhkczvjdslpwrorji4thpga 35 33 additional additional JJ work_y6xvhkczvjdslpwrorji4thpga 35 34 studies study NNS work_y6xvhkczvjdslpwrorji4thpga 35 35 are be VBP work_y6xvhkczvjdslpwrorji4thpga 35 36 re- re- RB work_y6xvhkczvjdslpwrorji4thpga 35 37 quired quire VBN work_y6xvhkczvjdslpwrorji4thpga 35 38 to to TO work_y6xvhkczvjdslpwrorji4thpga 35 39 determine determine VB work_y6xvhkczvjdslpwrorji4thpga 35 40 how how WRB work_y6xvhkczvjdslpwrorji4thpga 35 41 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 35 42 functions function NNS work_y6xvhkczvjdslpwrorji4thpga 35 43 and and CC work_y6xvhkczvjdslpwrorji4thpga 35 44 how how WRB work_y6xvhkczvjdslpwrorji4thpga 35 45 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 35 46 cause cause VBP work_y6xvhkczvjdslpwrorji4thpga 35 47 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 35 48 . . . work_y6xvhkczvjdslpwrorji4thpga 36 1 Nevertheless nevertheless RB work_y6xvhkczvjdslpwrorji4thpga 36 2 , , , work_y6xvhkczvjdslpwrorji4thpga 36 3 the the DT work_y6xvhkczvjdslpwrorji4thpga 36 4 identification identification NN work_y6xvhkczvjdslpwrorji4thpga 36 5 of of IN work_y6xvhkczvjdslpwrorji4thpga 36 6 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 36 7 as as IN work_y6xvhkczvjdslpwrorji4thpga 36 8 the the DT work_y6xvhkczvjdslpwrorji4thpga 36 9 defect defect NN work_y6xvhkczvjdslpwrorji4thpga 36 10 in in IN work_y6xvhkczvjdslpwrorji4thpga 36 11 PFIC1 PFIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 36 12 and and CC work_y6xvhkczvjdslpwrorji4thpga 36 13 BRIC BRIC NNP work_y6xvhkczvjdslpwrorji4thpga 36 14 represents represent VBZ work_y6xvhkczvjdslpwrorji4thpga 36 15 a a DT work_y6xvhkczvjdslpwrorji4thpga 36 16 significant significant JJ work_y6xvhkczvjdslpwrorji4thpga 36 17 shift shift NN work_y6xvhkczvjdslpwrorji4thpga 36 18 in in IN work_y6xvhkczvjdslpwrorji4thpga 36 19 our -PRON- PRP$ work_y6xvhkczvjdslpwrorji4thpga 36 20 understanding understanding NN work_y6xvhkczvjdslpwrorji4thpga 36 21 of of IN work_y6xvhkczvjdslpwrorji4thpga 36 22 the the DT work_y6xvhkczvjdslpwrorji4thpga 36 23 pathophysiology pathophysiology NN work_y6xvhkczvjdslpwrorji4thpga 36 24 of of IN work_y6xvhkczvjdslpwrorji4thpga 36 25 cholestatic cholestatic JJ work_y6xvhkczvjdslpwrorji4thpga 36 26 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 36 27 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 36 28 . . . work_y6xvhkczvjdslpwrorji4thpga 37 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 37 2 the the DT work_y6xvhkczvjdslpwrorji4thpga 37 3 second second JJ work_y6xvhkczvjdslpwrorji4thpga 37 4 study study NN work_y6xvhkczvjdslpwrorji4thpga 37 5 , , , work_y6xvhkczvjdslpwrorji4thpga 37 6 two two CD work_y6xvhkczvjdslpwrorji4thpga 37 7 children child NNS work_y6xvhkczvjdslpwrorji4thpga 37 8 with with IN work_y6xvhkczvjdslpwrorji4thpga 37 9 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 37 10 and and CC work_y6xvhkczvjdslpwrorji4thpga 37 11 high high JJ work_y6xvhkczvjdslpwrorji4thpga 37 12 serum serum NN work_y6xvhkczvjdslpwrorji4thpga 37 13 GGTP ggtp NN work_y6xvhkczvjdslpwrorji4thpga 37 14 levels level NNS work_y6xvhkczvjdslpwrorji4thpga 37 15 were be VBD work_y6xvhkczvjdslpwrorji4thpga 37 16 found find VBN work_y6xvhkczvjdslpwrorji4thpga 37 17 to to TO work_y6xvhkczvjdslpwrorji4thpga 37 18 have have VB work_y6xvhkczvjdslpwrorji4thpga 37 19 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 37 20 in in IN work_y6xvhkczvjdslpwrorji4thpga 37 21 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 37 22 . . . work_y6xvhkczvjdslpwrorji4thpga 38 1 Canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 38 2 staining stain VBG work_y6xvhkczvjdslpwrorji4thpga 38 3 for for IN work_y6xvhkczvjdslpwrorji4thpga 38 4 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 38 5 P P NNP work_y6xvhkczvjdslpwrorji4thpga 38 6 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 38 7 glycoprotein glycoprotein NNP work_y6xvhkczvjdslpwrorji4thpga 38 8 was be VBD work_y6xvhkczvjdslpwrorji4thpga 38 9 absent absent JJ work_y6xvhkczvjdslpwrorji4thpga 38 10 in in IN work_y6xvhkczvjdslpwrorji4thpga 38 11 liver liver JJ work_y6xvhkczvjdslpwrorji4thpga 38 12 biopsy biopsy NN work_y6xvhkczvjdslpwrorji4thpga 38 13 specimens specimen NNS work_y6xvhkczvjdslpwrorji4thpga 38 14 in in IN work_y6xvhkczvjdslpwrorji4thpga 38 15 both both DT work_y6xvhkczvjdslpwrorji4thpga 38 16 children child NNS work_y6xvhkczvjdslpwrorji4thpga 38 17 . . . work_y6xvhkczvjdslpwrorji4thpga 39 1 As as IN work_y6xvhkczvjdslpwrorji4thpga 39 2 a a DT work_y6xvhkczvjdslpwrorji4thpga 39 3 control control NN work_y6xvhkczvjdslpwrorji4thpga 39 4 , , , work_y6xvhkczvjdslpwrorji4thpga 39 5 staining stain VBG work_y6xvhkczvjdslpwrorji4thpga 39 6 of of IN work_y6xvhkczvjdslpwrorji4thpga 39 7 the the DT work_y6xvhkczvjdslpwrorji4thpga 39 8 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 39 9 membranes membrane NNS work_y6xvhkczvjdslpwrorji4thpga 39 10 with with IN work_y6xvhkczvjdslpwrorji4thpga 39 11 antibodies antibody NNS work_y6xvhkczvjdslpwrorji4thpga 39 12 directed direct VBN work_y6xvhkczvjdslpwrorji4thpga 39 13 against against IN work_y6xvhkczvjdslpwrorji4thpga 39 14 MDR1 MDR1 NNP work_y6xvhkczvjdslpwrorji4thpga 39 15 P P NNP work_y6xvhkczvjdslpwrorji4thpga 39 16 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 39 17 glycoprotein glycoprotein NNP work_y6xvhkczvjdslpwrorji4thpga 39 18 and and CC work_y6xvhkczvjdslpwrorji4thpga 39 19 MRP2 MRP2 NNP work_y6xvhkczvjdslpwrorji4thpga 39 20 / / SYM work_y6xvhkczvjdslpwrorji4thpga 39 21 cmoat cmoat NNP work_y6xvhkczvjdslpwrorji4thpga 39 22 , , , work_y6xvhkczvjdslpwrorji4thpga 39 23 the the DT work_y6xvhkczvjdslpwrorji4thpga 39 24 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 39 25 trans- trans- JJ work_y6xvhkczvjdslpwrorji4thpga 39 26 porter porter NN work_y6xvhkczvjdslpwrorji4thpga 39 27 involved involve VBN work_y6xvhkczvjdslpwrorji4thpga 39 28 in in IN work_y6xvhkczvjdslpwrorji4thpga 39 29 the the DT work_y6xvhkczvjdslpwrorji4thpga 39 30 secretion secretion NN work_y6xvhkczvjdslpwrorji4thpga 39 31 of of IN work_y6xvhkczvjdslpwrorji4thpga 39 32 nonbile nonbile NN work_y6xvhkczvjdslpwrorji4thpga 39 33 acid acid NN work_y6xvhkczvjdslpwrorji4thpga 39 34 organic organic JJ work_y6xvhkczvjdslpwrorji4thpga 39 35 anions anion NNS work_y6xvhkczvjdslpwrorji4thpga 39 36 , , , work_y6xvhkczvjdslpwrorji4thpga 39 37 was be VBD work_y6xvhkczvjdslpwrorji4thpga 39 38 normal normal JJ work_y6xvhkczvjdslpwrorji4thpga 39 39 . . . work_y6xvhkczvjdslpwrorji4thpga 40 1 Two two CD work_y6xvhkczvjdslpwrorji4thpga 40 2 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 40 3 were be VBD work_y6xvhkczvjdslpwrorji4thpga 40 4 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 40 5 using use VBG work_y6xvhkczvjdslpwrorji4thpga 40 6 reverse reverse JJ work_y6xvhkczvjdslpwrorji4thpga 40 7 transcription transcription NN work_y6xvhkczvjdslpwrorji4thpga 40 8 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 40 9 polymerase polymerase NN work_y6xvhkczvjdslpwrorji4thpga 40 10 chain chain NN work_y6xvhkczvjdslpwrorji4thpga 40 11 reaction reaction NN work_y6xvhkczvjdslpwrorji4thpga 40 12 ; ; : work_y6xvhkczvjdslpwrorji4thpga 40 13 a a DT work_y6xvhkczvjdslpwrorji4thpga 40 14 seven- seven- NN work_y6xvhkczvjdslpwrorji4thpga 40 15 nucleotide nucleotide JJ work_y6xvhkczvjdslpwrorji4thpga 40 16 deletion deletion NN work_y6xvhkczvjdslpwrorji4thpga 40 17 and and CC work_y6xvhkczvjdslpwrorji4thpga 40 18 a a DT work_y6xvhkczvjdslpwrorji4thpga 40 19 single single JJ work_y6xvhkczvjdslpwrorji4thpga 40 20 nonsense nonsense NN work_y6xvhkczvjdslpwrorji4thpga 40 21 mutation mutation NN work_y6xvhkczvjdslpwrorji4thpga 40 22 , , , work_y6xvhkczvjdslpwrorji4thpga 40 23 both both DT work_y6xvhkczvjdslpwrorji4thpga 40 24 resulting result VBG work_y6xvhkczvjdslpwrorji4thpga 40 25 in in IN work_y6xvhkczvjdslpwrorji4thpga 40 26 the the DT work_y6xvhkczvjdslpwrorji4thpga 40 27 introduction introduction NN work_y6xvhkczvjdslpwrorji4thpga 40 28 of of IN work_y6xvhkczvjdslpwrorji4thpga 40 29 stop stop NN work_y6xvhkczvjdslpwrorji4thpga 40 30 codons codon NNS work_y6xvhkczvjdslpwrorji4thpga 40 31 and and CC work_y6xvhkczvjdslpwrorji4thpga 40 32 truncated truncate VBN work_y6xvhkczvjdslpwrorji4thpga 40 33 messenger messenger NN work_y6xvhkczvjdslpwrorji4thpga 40 34 RNA RNA NNP work_y6xvhkczvjdslpwrorji4thpga 40 35 . . . work_y6xvhkczvjdslpwrorji4thpga 41 1 This this DT work_y6xvhkczvjdslpwrorji4thpga 41 2 finding finding NN work_y6xvhkczvjdslpwrorji4thpga 41 3 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 41 4 another another DT work_y6xvhkczvjdslpwrorji4thpga 41 5 milestone milestone NN work_y6xvhkczvjdslpwrorji4thpga 41 6 in in IN work_y6xvhkczvjdslpwrorji4thpga 41 7 our -PRON- PRP$ work_y6xvhkczvjdslpwrorji4thpga 41 8 understanding understanding NN work_y6xvhkczvjdslpwrorji4thpga 41 9 of of IN work_y6xvhkczvjdslpwrorji4thpga 41 10 cholestatic cholestatic JJ work_y6xvhkczvjdslpwrorji4thpga 41 11 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 41 12 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 41 13 . . . work_y6xvhkczvjdslpwrorji4thpga 42 1 By by IN work_y6xvhkczvjdslpwrorji4thpga 42 2 starting start VBG work_y6xvhkczvjdslpwrorji4thpga 42 3 with with IN work_y6xvhkczvjdslpwrorji4thpga 42 4 a a DT work_y6xvhkczvjdslpwrorji4thpga 42 5 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 42 6 , , , work_y6xvhkczvjdslpwrorji4thpga 42 7 in in IN work_y6xvhkczvjdslpwrorji4thpga 42 8 this this DT work_y6xvhkczvjdslpwrorji4thpga 42 9 case case NN work_y6xvhkczvjdslpwrorji4thpga 42 10 mdr2 mdr2 NN work_y6xvhkczvjdslpwrorji4thpga 42 11 in in IN work_y6xvhkczvjdslpwrorji4thpga 42 12 the the DT work_y6xvhkczvjdslpwrorji4thpga 42 13 mouse mouse NN work_y6xvhkczvjdslpwrorji4thpga 42 14 , , , work_y6xvhkczvjdslpwrorji4thpga 42 15 and and CC work_y6xvhkczvjdslpwrorji4thpga 42 16 determining determine VBG work_y6xvhkczvjdslpwrorji4thpga 42 17 its -PRON- PRP$ work_y6xvhkczvjdslpwrorji4thpga 42 18 function function NN work_y6xvhkczvjdslpwrorji4thpga 42 19 to to TO work_y6xvhkczvjdslpwrorji4thpga 42 20 define define VB work_y6xvhkczvjdslpwrorji4thpga 42 21 a a DT work_y6xvhkczvjdslpwrorji4thpga 42 22 phenotype phenotype NN work_y6xvhkczvjdslpwrorji4thpga 42 23 , , , work_y6xvhkczvjdslpwrorji4thpga 42 24 it -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 42 25 represents represent VBZ work_y6xvhkczvjdslpwrorji4thpga 42 26 a a DT work_y6xvhkczvjdslpwrorji4thpga 42 27 fundamentally fundamentally RB work_y6xvhkczvjdslpwrorji4thpga 42 28 different different JJ work_y6xvhkczvjdslpwrorji4thpga 42 29 but but CC work_y6xvhkczvjdslpwrorji4thpga 42 30 equally equally RB work_y6xvhkczvjdslpwrorji4thpga 42 31 successful successful JJ work_y6xvhkczvjdslpwrorji4thpga 42 32 approach approach NN work_y6xvhkczvjdslpwrorji4thpga 42 33 to to IN work_y6xvhkczvjdslpwrorji4thpga 42 34 that that DT work_y6xvhkczvjdslpwrorji4thpga 42 35 pursued pursue VBN work_y6xvhkczvjdslpwrorji4thpga 42 36 in in IN work_y6xvhkczvjdslpwrorji4thpga 42 37 the the DT work_y6xvhkczvjdslpwrorji4thpga 42 38 first first JJ work_y6xvhkczvjdslpwrorji4thpga 42 39 study study NN work_y6xvhkczvjdslpwrorji4thpga 42 40 in in IN work_y6xvhkczvjdslpwrorji4thpga 42 41 which which WDT work_y6xvhkczvjdslpwrorji4thpga 42 42 a a DT work_y6xvhkczvjdslpwrorji4thpga 42 43 defined define VBN work_y6xvhkczvjdslpwrorji4thpga 42 44 phenotype phenotype NN work_y6xvhkczvjdslpwrorji4thpga 42 45 was be VBD work_y6xvhkczvjdslpwrorji4thpga 42 46 used use VBN work_y6xvhkczvjdslpwrorji4thpga 42 47 to to TO work_y6xvhkczvjdslpwrorji4thpga 42 48 identify identify VB work_y6xvhkczvjdslpwrorji4thpga 42 49 a a DT work_y6xvhkczvjdslpwrorji4thpga 42 50 defective defective JJ work_y6xvhkczvjdslpwrorji4thpga 42 51 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 42 52 . . . work_y6xvhkczvjdslpwrorji4thpga 43 1 Another another DT work_y6xvhkczvjdslpwrorji4thpga 43 2 locus locus NN work_y6xvhkczvjdslpwrorji4thpga 43 3 for for IN work_y6xvhkczvjdslpwrorji4thpga 43 4 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 43 5 has have VBZ work_y6xvhkczvjdslpwrorji4thpga 43 6 been be VBN work_y6xvhkczvjdslpwrorji4thpga 43 7 recently recently RB work_y6xvhkczvjdslpwrorji4thpga 43 8 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 43 9 on on IN work_y6xvhkczvjdslpwrorji4thpga 43 10 chromosome chromosome NN work_y6xvhkczvjdslpwrorji4thpga 43 11 2q24 2q24 CD work_y6xvhkczvjdslpwrorji4thpga 43 12 and and CC work_y6xvhkczvjdslpwrorji4thpga 43 13 designated designate VBD work_y6xvhkczvjdslpwrorji4thpga 43 14 PFIC2.14 PFIC2.14 NNP work_y6xvhkczvjdslpwrorji4thpga 43 15 This this DT work_y6xvhkczvjdslpwrorji4thpga 43 16 locus locus NN work_y6xvhkczvjdslpwrorji4thpga 43 17 corre- corre- NN work_y6xvhkczvjdslpwrorji4thpga 43 18 sponds spond NNS work_y6xvhkczvjdslpwrorji4thpga 43 19 to to IN work_y6xvhkczvjdslpwrorji4thpga 43 20 that that DT work_y6xvhkczvjdslpwrorji4thpga 43 21 of of IN work_y6xvhkczvjdslpwrorji4thpga 43 22 the the DT work_y6xvhkczvjdslpwrorji4thpga 43 23 human human JJ work_y6xvhkczvjdslpwrorji4thpga 43 24 sister sister NN work_y6xvhkczvjdslpwrorji4thpga 43 25 P P NNP work_y6xvhkczvjdslpwrorji4thpga 43 26 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 43 27 glycoprotein glycoprotein NNP work_y6xvhkczvjdslpwrorji4thpga 43 28 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 43 29 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 43 30 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 43 31 gene.15 gene.15 NNP work_y6xvhkczvjdslpwrorji4thpga 43 32 The the DT work_y6xvhkczvjdslpwrorji4thpga 43 33 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 43 34 product product NN work_y6xvhkczvjdslpwrorji4thpga 43 35 of of IN work_y6xvhkczvjdslpwrorji4thpga 43 36 this this DT work_y6xvhkczvjdslpwrorji4thpga 43 37 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 43 38 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 43 39 specific specific JJ work_y6xvhkczvjdslpwrorji4thpga 43 40 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 43 41 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 43 42 abundantly abundantly RB work_y6xvhkczvjdslpwrorji4thpga 43 43 expressed express VBN work_y6xvhkczvjdslpwrorji4thpga 43 44 on on IN work_y6xvhkczvjdslpwrorji4thpga 43 45 the the DT work_y6xvhkczvjdslpwrorji4thpga 43 46 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 43 47 membrane.16 membrane.16 NNP work_y6xvhkczvjdslpwrorji4thpga 43 48 Rat Rat NNP work_y6xvhkczvjdslpwrorji4thpga 43 49 spgp spgp NNS work_y6xvhkczvjdslpwrorji4thpga 43 50 expressed express VBD work_y6xvhkczvjdslpwrorji4thpga 43 51 in in IN work_y6xvhkczvjdslpwrorji4thpga 43 52 Xenopus Xenopus NNP work_y6xvhkczvjdslpwrorji4thpga 43 53 oocytes oocyte NNS work_y6xvhkczvjdslpwrorji4thpga 43 54 and and CC work_y6xvhkczvjdslpwrorji4thpga 43 55 in in IN work_y6xvhkczvjdslpwrorji4thpga 43 56 membrane membrane NN work_y6xvhkczvjdslpwrorji4thpga 43 57 vesicles vesicle NNS work_y6xvhkczvjdslpwrorji4thpga 43 58 isolated isolate VBN work_y6xvhkczvjdslpwrorji4thpga 43 59 from from IN work_y6xvhkczvjdslpwrorji4thpga 43 60 transfected transfecte VBN work_y6xvhkczvjdslpwrorji4thpga 43 61 Sf9 sf9 JJ work_y6xvhkczvjdslpwrorji4thpga 43 62 insect insect NN work_y6xvhkczvjdslpwrorji4thpga 43 63 cells cell NNS work_y6xvhkczvjdslpwrorji4thpga 43 64 was be VBD work_y6xvhkczvjdslpwrorji4thpga 43 65 recently recently RB work_y6xvhkczvjdslpwrorji4thpga 43 66 found find VBN work_y6xvhkczvjdslpwrorji4thpga 43 67 to to TO work_y6xvhkczvjdslpwrorji4thpga 43 68 mediate mediate VB work_y6xvhkczvjdslpwrorji4thpga 43 69 adenosine adenosine NNP work_y6xvhkczvjdslpwrorji4thpga 43 70 triphosphate triphosphate NNP work_y6xvhkczvjdslpwrorji4thpga 43 71 – – : work_y6xvhkczvjdslpwrorji4thpga 43 72 dependent dependent JJ work_y6xvhkczvjdslpwrorji4thpga 43 73 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 43 74 acid acid NN work_y6xvhkczvjdslpwrorji4thpga 43 75 trans- trans- NN work_y6xvhkczvjdslpwrorji4thpga 43 76 port.17 port.17 NNP work_y6xvhkczvjdslpwrorji4thpga 43 77 Furthermore furthermore RB work_y6xvhkczvjdslpwrorji4thpga 43 78 , , , work_y6xvhkczvjdslpwrorji4thpga 43 79 taurochenodeoxycholate taurochenodeoxycholate NN work_y6xvhkczvjdslpwrorji4thpga 43 80 , , , work_y6xvhkczvjdslpwrorji4thpga 43 81 the the DT work_y6xvhkczvjdslpwrorji4thpga 43 82 concentra- concentra- NNP work_y6xvhkczvjdslpwrorji4thpga 43 83 tion tion NN work_y6xvhkczvjdslpwrorji4thpga 43 84 of of IN work_y6xvhkczvjdslpwrorji4thpga 43 85 which which WDT work_y6xvhkczvjdslpwrorji4thpga 43 86 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 43 87 strikingly strikingly RB work_y6xvhkczvjdslpwrorji4thpga 43 88 low low JJ work_y6xvhkczvjdslpwrorji4thpga 43 89 in in IN work_y6xvhkczvjdslpwrorji4thpga 43 90 gallbladder gallbladder NN work_y6xvhkczvjdslpwrorji4thpga 43 91 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 43 92 from from IN work_y6xvhkczvjdslpwrorji4thpga 43 93 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 43 94 patients,11 patients,11 NN work_y6xvhkczvjdslpwrorji4thpga 43 95 was be VBD work_y6xvhkczvjdslpwrorji4thpga 43 96 the the DT work_y6xvhkczvjdslpwrorji4thpga 43 97 preferred preferred JJ work_y6xvhkczvjdslpwrorji4thpga 43 98 substrate substrate NN work_y6xvhkczvjdslpwrorji4thpga 43 99 for for IN work_y6xvhkczvjdslpwrorji4thpga 43 100 spgp.17 spgp.17 NNP work_y6xvhkczvjdslpwrorji4thpga 43 101 These these DT work_y6xvhkczvjdslpwrorji4thpga 43 102 findings finding NNS work_y6xvhkczvjdslpwrorji4thpga 43 103 suggest suggest VBP work_y6xvhkczvjdslpwrorji4thpga 43 104 that that IN work_y6xvhkczvjdslpwrorji4thpga 43 105 spgp spgp NNS work_y6xvhkczvjdslpwrorji4thpga 43 106 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 43 107 a a DT work_y6xvhkczvjdslpwrorji4thpga 43 108 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 43 109 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 43 110 acid acid NN work_y6xvhkczvjdslpwrorji4thpga 43 111 trans- trans- NNP work_y6xvhkczvjdslpwrorji4thpga 43 112 porter porter NNP work_y6xvhkczvjdslpwrorji4thpga 43 113 and and CC work_y6xvhkczvjdslpwrorji4thpga 43 114 that that IN work_y6xvhkczvjdslpwrorji4thpga 43 115 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 43 116 of of IN work_y6xvhkczvjdslpwrorji4thpga 43 117 the the DT work_y6xvhkczvjdslpwrorji4thpga 43 118 human human JJ work_y6xvhkczvjdslpwrorji4thpga 43 119 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 43 120 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 43 121 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 43 122 are be VBP work_y6xvhkczvjdslpwrorji4thpga 43 123 responsible responsible JJ work_y6xvhkczvjdslpwrorji4thpga 43 124 for for IN work_y6xvhkczvjdslpwrorji4thpga 43 125 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 43 126 type type NN work_y6xvhkczvjdslpwrorji4thpga 43 127 2 2 CD work_y6xvhkczvjdslpwrorji4thpga 43 128 . . . work_y6xvhkczvjdslpwrorji4thpga 44 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 44 2 three three CD work_y6xvhkczvjdslpwrorji4thpga 44 3 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 44 4 with with IN work_y6xvhkczvjdslpwrorji4thpga 44 5 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 44 6 and and CC work_y6xvhkczvjdslpwrorji4thpga 44 7 normal normal JJ work_y6xvhkczvjdslpwrorji4thpga 44 8 serum serum NN work_y6xvhkczvjdslpwrorji4thpga 44 9 GGTP ggtp NN work_y6xvhkczvjdslpwrorji4thpga 44 10 levels level NNS work_y6xvhkczvjdslpwrorji4thpga 44 11 , , , work_y6xvhkczvjdslpwrorji4thpga 44 12 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 44 13 messenger messenger NN work_y6xvhkczvjdslpwrorji4thpga 44 14 RNA RNA NNP work_y6xvhkczvjdslpwrorji4thpga 44 15 was be VBD work_y6xvhkczvjdslpwrorji4thpga 44 16 normal normal JJ work_y6xvhkczvjdslpwrorji4thpga 44 17 but but CC work_y6xvhkczvjdslpwrorji4thpga 44 18 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 44 19 was be VBD work_y6xvhkczvjdslpwrorji4thpga 44 20 undetectable undetectable JJ work_y6xvhkczvjdslpwrorji4thpga 44 21 on on IN work_y6xvhkczvjdslpwrorji4thpga 44 22 the the DT work_y6xvhkczvjdslpwrorji4thpga 44 23 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 44 24 mem- mem- NNP work_y6xvhkczvjdslpwrorji4thpga 44 25 brane brane NN work_y6xvhkczvjdslpwrorji4thpga 44 26 by by IN work_y6xvhkczvjdslpwrorji4thpga 44 27 immunohistochemistry,18 immunohistochemistry,18 NNP work_y6xvhkczvjdslpwrorji4thpga 44 28 consistent consistent JJ work_y6xvhkczvjdslpwrorji4thpga 44 29 with with IN work_y6xvhkczvjdslpwrorji4thpga 44 30 a a DT work_y6xvhkczvjdslpwrorji4thpga 44 31 traffick- traffick- NN work_y6xvhkczvjdslpwrorji4thpga 44 32 ing ing NN work_y6xvhkczvjdslpwrorji4thpga 44 33 defect defect NN work_y6xvhkczvjdslpwrorji4thpga 44 34 . . . work_y6xvhkczvjdslpwrorji4thpga 45 1 To to IN work_y6xvhkczvjdslpwrorji4thpga 45 2 date date NN work_y6xvhkczvjdslpwrorji4thpga 45 3 , , , work_y6xvhkczvjdslpwrorji4thpga 45 4 15 15 CD work_y6xvhkczvjdslpwrorji4thpga 45 5 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 45 6 in in IN work_y6xvhkczvjdslpwrorji4thpga 45 7 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 45 8 have have VBP work_y6xvhkczvjdslpwrorji4thpga 45 9 been be VBN work_y6xvhkczvjdslpwrorji4thpga 45 10 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 45 11 in in IN work_y6xvhkczvjdslpwrorji4thpga 45 12 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 45 13 with with IN work_y6xvhkczvjdslpwrorji4thpga 45 14 PFIC2 pfic2 NN work_y6xvhkczvjdslpwrorji4thpga 45 15 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 45 16 Richard Richard NNP work_y6xvhkczvjdslpwrorji4thpga 45 17 Thompson Thompson NNP work_y6xvhkczvjdslpwrorji4thpga 45 18 , , , work_y6xvhkczvjdslpwrorji4thpga 45 19 Depart- Depart- NNP work_y6xvhkczvjdslpwrorji4thpga 45 20 ment ment NN work_y6xvhkczvjdslpwrorji4thpga 45 21 of of IN work_y6xvhkczvjdslpwrorji4thpga 45 22 Pediatrics Pediatrics NNPS work_y6xvhkczvjdslpwrorji4thpga 45 23 , , , work_y6xvhkczvjdslpwrorji4thpga 45 24 University University NNP work_y6xvhkczvjdslpwrorji4thpga 45 25 College College NNP work_y6xvhkczvjdslpwrorji4thpga 45 26 London London NNP work_y6xvhkczvjdslpwrorji4thpga 45 27 Medical Medical NNP work_y6xvhkczvjdslpwrorji4thpga 45 28 School School NNP work_y6xvhkczvjdslpwrorji4thpga 45 29 , , , work_y6xvhkczvjdslpwrorji4thpga 45 30 London London NNP work_y6xvhkczvjdslpwrorji4thpga 45 31 , , , work_y6xvhkczvjdslpwrorji4thpga 45 32 UK UK NNP work_y6xvhkczvjdslpwrorji4thpga 45 33 , , , work_y6xvhkczvjdslpwrorji4thpga 45 34 personal personal JJ work_y6xvhkczvjdslpwrorji4thpga 45 35 communication communication NN work_y6xvhkczvjdslpwrorji4thpga 45 36 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 45 37 . . . work_y6xvhkczvjdslpwrorji4thpga 46 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 46 2 summary summary NN work_y6xvhkczvjdslpwrorji4thpga 46 3 , , , work_y6xvhkczvjdslpwrorji4thpga 46 4 the the DT work_y6xvhkczvjdslpwrorji4thpga 46 5 molecular molecular JJ work_y6xvhkczvjdslpwrorji4thpga 46 6 basis basis NN work_y6xvhkczvjdslpwrorji4thpga 46 7 for for IN work_y6xvhkczvjdslpwrorji4thpga 46 8 all all DT work_y6xvhkczvjdslpwrorji4thpga 46 9 forms form NNS work_y6xvhkczvjdslpwrorji4thpga 46 10 of of IN work_y6xvhkczvjdslpwrorji4thpga 46 11 PFIC PFIC NNP work_y6xvhkczvjdslpwrorji4thpga 46 12 may may MD work_y6xvhkczvjdslpwrorji4thpga 46 13 now now RB work_y6xvhkczvjdslpwrorji4thpga 46 14 have have VB work_y6xvhkczvjdslpwrorji4thpga 46 15 been be VBN work_y6xvhkczvjdslpwrorji4thpga 46 16 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 46 17 . . . work_y6xvhkczvjdslpwrorji4thpga 47 1 However however RB work_y6xvhkczvjdslpwrorji4thpga 47 2 , , , work_y6xvhkczvjdslpwrorji4thpga 47 3 the the DT work_y6xvhkczvjdslpwrorji4thpga 47 4 implications implication NNS work_y6xvhkczvjdslpwrorji4thpga 47 5 of of IN work_y6xvhkczvjdslpwrorji4thpga 47 6 these these DT work_y6xvhkczvjdslpwrorji4thpga 47 7 findings finding NNS work_y6xvhkczvjdslpwrorji4thpga 47 8 may may MD work_y6xvhkczvjdslpwrorji4thpga 47 9 extend extend VB work_y6xvhkczvjdslpwrorji4thpga 47 10 far far RB work_y6xvhkczvjdslpwrorji4thpga 47 11 beyond beyond IN work_y6xvhkczvjdslpwrorji4thpga 47 12 a a DT work_y6xvhkczvjdslpwrorji4thpga 47 13 mere mere JJ work_y6xvhkczvjdslpwrorji4thpga 47 14 understanding understanding NN work_y6xvhkczvjdslpwrorji4thpga 47 15 of of IN work_y6xvhkczvjdslpwrorji4thpga 47 16 a a DT work_y6xvhkczvjdslpwrorji4thpga 47 17 group group NN work_y6xvhkczvjdslpwrorji4thpga 47 18 of of IN work_y6xvhkczvjdslpwrorji4thpga 47 19 relatively relatively RB work_y6xvhkczvjdslpwrorji4thpga 47 20 rare rare JJ work_y6xvhkczvjdslpwrorji4thpga 47 21 inherited inherit VBN work_y6xvhkczvjdslpwrorji4thpga 47 22 cholestatic cholestatic JJ work_y6xvhkczvjdslpwrorji4thpga 47 23 disorders disorder NNS work_y6xvhkczvjdslpwrorji4thpga 47 24 . . . work_y6xvhkczvjdslpwrorji4thpga 48 1 Lith1 Lith1 NNP work_y6xvhkczvjdslpwrorji4thpga 48 2 , , , work_y6xvhkczvjdslpwrorji4thpga 48 3 a a DT work_y6xvhkczvjdslpwrorji4thpga 48 4 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 48 5 that that WDT work_y6xvhkczvjdslpwrorji4thpga 48 6 has have VBZ work_y6xvhkczvjdslpwrorji4thpga 48 7 been be VBN work_y6xvhkczvjdslpwrorji4thpga 48 8 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 48 9 as as IN work_y6xvhkczvjdslpwrorji4thpga 48 10 a a DT work_y6xvhkczvjdslpwrorji4thpga 48 11 determinant determinant NN work_y6xvhkczvjdslpwrorji4thpga 48 12 of of IN work_y6xvhkczvjdslpwrorji4thpga 48 13 cholesterol cholesterol NN work_y6xvhkczvjdslpwrorji4thpga 48 14 gallstone gallstone PRP$ work_y6xvhkczvjdslpwrorji4thpga 48 15 susceptibility susceptibility NN work_y6xvhkczvjdslpwrorji4thpga 48 16 in in IN work_y6xvhkczvjdslpwrorji4thpga 48 17 inbred inbreed VBN work_y6xvhkczvjdslpwrorji4thpga 48 18 mice mouse NNS work_y6xvhkczvjdslpwrorji4thpga 48 19 , , , work_y6xvhkczvjdslpwrorji4thpga 48 20 co co NNS work_y6xvhkczvjdslpwrorji4thpga 48 21 - - NNS work_y6xvhkczvjdslpwrorji4thpga 48 22 localizes localize NNS work_y6xvhkczvjdslpwrorji4thpga 48 23 with with IN work_y6xvhkczvjdslpwrorji4thpga 48 24 spgp.19 spgp.19 NNP work_y6xvhkczvjdslpwrorji4thpga 48 25 Thus thus RB work_y6xvhkczvjdslpwrorji4thpga 48 26 , , , work_y6xvhkczvjdslpwrorji4thpga 48 27 a a DT work_y6xvhkczvjdslpwrorji4thpga 48 28 potential potential JJ work_y6xvhkczvjdslpwrorji4thpga 48 29 link link NN work_y6xvhkczvjdslpwrorji4thpga 48 30 has have VBZ work_y6xvhkczvjdslpwrorji4thpga 48 31 been be VBN work_y6xvhkczvjdslpwrorji4thpga 48 32 established establish VBN work_y6xvhkczvjdslpwrorji4thpga 48 33 between between IN work_y6xvhkczvjdslpwrorji4thpga 48 34 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 48 35 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 48 36 salt salt NN work_y6xvhkczvjdslpwrorji4thpga 48 37 secretion secretion NN work_y6xvhkczvjdslpwrorji4thpga 48 38 and and CC work_y6xvhkczvjdslpwrorji4thpga 48 39 cholesterol cholesterol NN work_y6xvhkczvjdslpwrorji4thpga 48 40 gallstone gallstone NN work_y6xvhkczvjdslpwrorji4thpga 48 41 forma- forma- NN work_y6xvhkczvjdslpwrorji4thpga 48 42 tion tion NN work_y6xvhkczvjdslpwrorji4thpga 48 43 . . . work_y6xvhkczvjdslpwrorji4thpga 49 1 Further further JJ work_y6xvhkczvjdslpwrorji4thpga 49 2 characterization characterization NN work_y6xvhkczvjdslpwrorji4thpga 49 3 of of IN work_y6xvhkczvjdslpwrorji4thpga 49 4 the the DT work_y6xvhkczvjdslpwrorji4thpga 49 5 function function NN work_y6xvhkczvjdslpwrorji4thpga 49 6 of of IN work_y6xvhkczvjdslpwrorji4thpga 49 7 the the DT work_y6xvhkczvjdslpwrorji4thpga 49 8 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 49 9 products product NNS work_y6xvhkczvjdslpwrorji4thpga 49 10 of of IN work_y6xvhkczvjdslpwrorji4thpga 49 11 FIC1 FIC1 NNP work_y6xvhkczvjdslpwrorji4thpga 49 12 , , , work_y6xvhkczvjdslpwrorji4thpga 49 13 MDR3 MDR3 NNP work_y6xvhkczvjdslpwrorji4thpga 49 14 , , , work_y6xvhkczvjdslpwrorji4thpga 49 15 and and CC work_y6xvhkczvjdslpwrorji4thpga 49 16 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 49 17 holds hold VBZ work_y6xvhkczvjdslpwrorji4thpga 49 18 the the DT work_y6xvhkczvjdslpwrorji4thpga 49 19 promise promise NN work_y6xvhkczvjdslpwrorji4thpga 49 20 of of IN work_y6xvhkczvjdslpwrorji4thpga 49 21 even even RB work_y6xvhkczvjdslpwrorji4thpga 49 22 more more JJR work_y6xvhkczvjdslpwrorji4thpga 49 23 advances advance NNS work_y6xvhkczvjdslpwrorji4thpga 49 24 in in IN work_y6xvhkczvjdslpwrorji4thpga 49 25 bridging bridge VBG work_y6xvhkczvjdslpwrorji4thpga 49 26 the the DT work_y6xvhkczvjdslpwrorji4thpga 49 27 gap gap NN work_y6xvhkczvjdslpwrorji4thpga 49 28 between between IN work_y6xvhkczvjdslpwrorji4thpga 49 29 the the DT work_y6xvhkczvjdslpwrorji4thpga 49 30 bench bench NN work_y6xvhkczvjdslpwrorji4thpga 49 31 and and CC work_y6xvhkczvjdslpwrorji4thpga 49 32 the the DT work_y6xvhkczvjdslpwrorji4thpga 49 33 bedside bedside NN work_y6xvhkczvjdslpwrorji4thpga 49 34 . . . work_y6xvhkczvjdslpwrorji4thpga 50 1 RICHARD RICHARD NNP work_y6xvhkczvjdslpwrorji4thpga 50 2 H. H. NNP work_y6xvhkczvjdslpwrorji4thpga 50 3 MOSELEY MOSELEY NNP work_y6xvhkczvjdslpwrorji4thpga 50 4 , , , work_y6xvhkczvjdslpwrorji4thpga 50 5 M.D. M.D. NNP work_y6xvhkczvjdslpwrorji4thpga 51 1 VA VA NNP work_y6xvhkczvjdslpwrorji4thpga 51 2 Medical Medical NNP work_y6xvhkczvjdslpwrorji4thpga 51 3 Center Center NNP work_y6xvhkczvjdslpwrorji4thpga 51 4 and and CC work_y6xvhkczvjdslpwrorji4thpga 51 5 University University NNP work_y6xvhkczvjdslpwrorji4thpga 51 6 of of IN work_y6xvhkczvjdslpwrorji4thpga 51 7 Michigan Michigan NNP work_y6xvhkczvjdslpwrorji4thpga 51 8 Medical Medical NNP work_y6xvhkczvjdslpwrorji4thpga 51 9 Center Center NNP work_y6xvhkczvjdslpwrorji4thpga 51 10 Ann Ann NNP work_y6xvhkczvjdslpwrorji4thpga 51 11 Arbor Arbor NNP work_y6xvhkczvjdslpwrorji4thpga 51 12 , , , work_y6xvhkczvjdslpwrorji4thpga 51 13 MI MI NNP work_y6xvhkczvjdslpwrorji4thpga 51 14 REFERENCES reference NNS work_y6xvhkczvjdslpwrorji4thpga 51 15 1 1 CD work_y6xvhkczvjdslpwrorji4thpga 51 16 . . . work_y6xvhkczvjdslpwrorji4thpga 52 1 Whitington Whitington NNP work_y6xvhkczvjdslpwrorji4thpga 52 2 PF PF NNP work_y6xvhkczvjdslpwrorji4thpga 52 3 , , , work_y6xvhkczvjdslpwrorji4thpga 52 4 Freese freese JJ work_y6xvhkczvjdslpwrorji4thpga 52 5 DK DK NNP work_y6xvhkczvjdslpwrorji4thpga 52 6 , , , work_y6xvhkczvjdslpwrorji4thpga 52 7 Alonso Alonso NNP work_y6xvhkczvjdslpwrorji4thpga 52 8 EM EM NNP work_y6xvhkczvjdslpwrorji4thpga 52 9 , , , work_y6xvhkczvjdslpwrorji4thpga 52 10 Schwarzenberg Schwarzenberg NNP work_y6xvhkczvjdslpwrorji4thpga 52 11 SJ SJ NNP work_y6xvhkczvjdslpwrorji4thpga 52 12 , , , work_y6xvhkczvjdslpwrorji4thpga 52 13 Sharp Sharp NNP work_y6xvhkczvjdslpwrorji4thpga 52 14 HL HL NNP work_y6xvhkczvjdslpwrorji4thpga 52 15 . . . work_y6xvhkczvjdslpwrorji4thpga 53 1 Clinical clinical JJ work_y6xvhkczvjdslpwrorji4thpga 53 2 and and CC work_y6xvhkczvjdslpwrorji4thpga 53 3 biochemical biochemical JJ work_y6xvhkczvjdslpwrorji4thpga 53 4 findings finding NNS work_y6xvhkczvjdslpwrorji4thpga 53 5 in in IN work_y6xvhkczvjdslpwrorji4thpga 53 6 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 53 7 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 53 8 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 53 9 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 53 10 . . . work_y6xvhkczvjdslpwrorji4thpga 54 1 J J NNP work_y6xvhkczvjdslpwrorji4thpga 54 2 Pediatr Pediatr NNP work_y6xvhkczvjdslpwrorji4thpga 54 3 Gastroenterol Gastroenterol NNP work_y6xvhkczvjdslpwrorji4thpga 54 4 Nutr Nutr NNP work_y6xvhkczvjdslpwrorji4thpga 54 5 1994;18:134 1994;18:134 CD work_y6xvhkczvjdslpwrorji4thpga 54 6 - - SYM work_y6xvhkczvjdslpwrorji4thpga 54 7 141 141 CD work_y6xvhkczvjdslpwrorji4thpga 54 8 . . . work_y6xvhkczvjdslpwrorji4thpga 55 1 2 2 LS work_y6xvhkczvjdslpwrorji4thpga 55 2 . . . work_y6xvhkczvjdslpwrorji4thpga 56 1 Alonso Alonso NNP work_y6xvhkczvjdslpwrorji4thpga 56 2 EM EM NNP work_y6xvhkczvjdslpwrorji4thpga 56 3 , , , work_y6xvhkczvjdslpwrorji4thpga 56 4 Snover Snover NNP work_y6xvhkczvjdslpwrorji4thpga 56 5 DC DC NNP work_y6xvhkczvjdslpwrorji4thpga 56 6 , , , work_y6xvhkczvjdslpwrorji4thpga 56 7 Montag Montag NNP work_y6xvhkczvjdslpwrorji4thpga 56 8 A A NNP work_y6xvhkczvjdslpwrorji4thpga 56 9 , , , work_y6xvhkczvjdslpwrorji4thpga 56 10 Freese freese JJ work_y6xvhkczvjdslpwrorji4thpga 56 11 DK DK NNP work_y6xvhkczvjdslpwrorji4thpga 56 12 , , , work_y6xvhkczvjdslpwrorji4thpga 56 13 Whitington Whitington NNP work_y6xvhkczvjdslpwrorji4thpga 56 14 PF PF NNP work_y6xvhkczvjdslpwrorji4thpga 56 15 . . . work_y6xvhkczvjdslpwrorji4thpga 57 1 Histologic histologic JJ work_y6xvhkczvjdslpwrorji4thpga 57 2 pathology pathology NN work_y6xvhkczvjdslpwrorji4thpga 57 3 of of IN work_y6xvhkczvjdslpwrorji4thpga 57 4 the the DT work_y6xvhkczvjdslpwrorji4thpga 57 5 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 57 6 in in IN work_y6xvhkczvjdslpwrorji4thpga 57 7 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 57 8 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 57 9 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 57 10 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 57 11 . . . work_y6xvhkczvjdslpwrorji4thpga 58 1 J J NNP work_y6xvhkczvjdslpwrorji4thpga 58 2 Pediatr Pediatr NNP work_y6xvhkczvjdslpwrorji4thpga 58 3 Gastro Gastro NNP work_y6xvhkczvjdslpwrorji4thpga 58 4 Nutri Nutri NNP work_y6xvhkczvjdslpwrorji4thpga 58 5 1994;18:128 1994;18:128 NNP work_y6xvhkczvjdslpwrorji4thpga 58 6 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 58 7 133 133 CD work_y6xvhkczvjdslpwrorji4thpga 58 8 . . . work_y6xvhkczvjdslpwrorji4thpga 59 1 3 3 LS work_y6xvhkczvjdslpwrorji4thpga 59 2 . . . work_y6xvhkczvjdslpwrorji4thpga 60 1 Clayton Clayton NNP work_y6xvhkczvjdslpwrorji4thpga 60 2 RJ RJ NNP work_y6xvhkczvjdslpwrorji4thpga 60 3 , , , work_y6xvhkczvjdslpwrorji4thpga 60 4 Iber Iber NNP work_y6xvhkczvjdslpwrorji4thpga 60 5 FL FL NNP work_y6xvhkczvjdslpwrorji4thpga 60 6 , , , work_y6xvhkczvjdslpwrorji4thpga 60 7 Ruebner Ruebner NNP work_y6xvhkczvjdslpwrorji4thpga 60 8 BH BH NNP work_y6xvhkczvjdslpwrorji4thpga 60 9 , , , work_y6xvhkczvjdslpwrorji4thpga 60 10 McKusick McKusick NNP work_y6xvhkczvjdslpwrorji4thpga 60 11 VA VA NNP work_y6xvhkczvjdslpwrorji4thpga 60 12 . . . work_y6xvhkczvjdslpwrorji4thpga 60 13 Byler byler NN work_y6xvhkczvjdslpwrorji4thpga 60 14 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 60 15 : : : work_y6xvhkczvjdslpwrorji4thpga 60 16 fatal fatal JJ work_y6xvhkczvjdslpwrorji4thpga 60 17 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 60 18 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 60 19 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 60 20 in in IN work_y6xvhkczvjdslpwrorji4thpga 60 21 an an DT work_y6xvhkczvjdslpwrorji4thpga 60 22 Amish amish JJ work_y6xvhkczvjdslpwrorji4thpga 60 23 kindred kindre VBN work_y6xvhkczvjdslpwrorji4thpga 60 24 . . . work_y6xvhkczvjdslpwrorji4thpga 61 1 Amer Amer NNP work_y6xvhkczvjdslpwrorji4thpga 61 2 J J NNP work_y6xvhkczvjdslpwrorji4thpga 61 3 Dis Dis NNP work_y6xvhkczvjdslpwrorji4thpga 61 4 Child Child NNP work_y6xvhkczvjdslpwrorji4thpga 61 5 1969;117:112 1969;117:112 CD work_y6xvhkczvjdslpwrorji4thpga 61 6 - - SYM work_y6xvhkczvjdslpwrorji4thpga 61 7 124 124 CD work_y6xvhkczvjdslpwrorji4thpga 61 8 . . . work_y6xvhkczvjdslpwrorji4thpga 62 1 4 4 LS work_y6xvhkczvjdslpwrorji4thpga 62 2 . . . work_y6xvhkczvjdslpwrorji4thpga 63 1 Bull Bull NNP work_y6xvhkczvjdslpwrorji4thpga 63 2 LN LN NNP work_y6xvhkczvjdslpwrorji4thpga 63 3 , , , work_y6xvhkczvjdslpwrorji4thpga 63 4 Carlton Carlton NNP work_y6xvhkczvjdslpwrorji4thpga 63 5 VEH VEH NNP work_y6xvhkczvjdslpwrorji4thpga 63 6 , , , work_y6xvhkczvjdslpwrorji4thpga 63 7 Stricker Stricker NNP work_y6xvhkczvjdslpwrorji4thpga 63 8 NL NL NNP work_y6xvhkczvjdslpwrorji4thpga 63 9 , , , work_y6xvhkczvjdslpwrorji4thpga 63 10 Baharloo Baharloo NNP work_y6xvhkczvjdslpwrorji4thpga 63 11 S S NNP work_y6xvhkczvjdslpwrorji4thpga 63 12 , , , work_y6xvhkczvjdslpwrorji4thpga 63 13 DeYoung DeYoung NNP work_y6xvhkczvjdslpwrorji4thpga 63 14 JA JA NNP work_y6xvhkczvjdslpwrorji4thpga 63 15 , , , work_y6xvhkczvjdslpwrorji4thpga 63 16 Freimer Freimer NNP work_y6xvhkczvjdslpwrorji4thpga 63 17 NB NB NNP work_y6xvhkczvjdslpwrorji4thpga 63 18 , , , work_y6xvhkczvjdslpwrorji4thpga 63 19 Magid Magid NNP work_y6xvhkczvjdslpwrorji4thpga 63 20 MS MS NNP work_y6xvhkczvjdslpwrorji4thpga 63 21 , , , work_y6xvhkczvjdslpwrorji4thpga 63 22 et et NNP work_y6xvhkczvjdslpwrorji4thpga 63 23 al2 al2 NNP work_y6xvhkczvjdslpwrorji4thpga 63 24 . . . work_y6xvhkczvjdslpwrorji4thpga 64 1 Genetic genetic JJ work_y6xvhkczvjdslpwrorji4thpga 64 2 and and CC work_y6xvhkczvjdslpwrorji4thpga 64 3 morphological morphological JJ work_y6xvhkczvjdslpwrorji4thpga 64 4 findings finding NNS work_y6xvhkczvjdslpwrorji4thpga 64 5 in in IN work_y6xvhkczvjdslpwrorji4thpga 64 6 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 64 7 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 64 8 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 64 9 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 64 10 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 64 11 Byler Byler NNP work_y6xvhkczvjdslpwrorji4thpga 64 12 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 64 13 [ [ -LRB- work_y6xvhkczvjdslpwrorji4thpga 64 14 PFIC-1 PFIC-1 NNP work_y6xvhkczvjdslpwrorji4thpga 64 15 ] ] -RRB- work_y6xvhkczvjdslpwrorji4thpga 64 16 and and CC work_y6xvhkczvjdslpwrorji4thpga 64 17 Byler Byler NNP work_y6xvhkczvjdslpwrorji4thpga 64 18 syndrome syndrome NN work_y6xvhkczvjdslpwrorji4thpga 64 19 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 64 20 : : : work_y6xvhkczvjdslpwrorji4thpga 64 21 evidence evidence NN work_y6xvhkczvjdslpwrorji4thpga 64 22 for for IN work_y6xvhkczvjdslpwrorji4thpga 64 23 heterogeneity heterogeneity NN work_y6xvhkczvjdslpwrorji4thpga 64 24 . . . work_y6xvhkczvjdslpwrorji4thpga 65 1 HEPATOLOGY HEPATOLOGY NNP work_y6xvhkczvjdslpwrorji4thpga 65 2 1997;26:155 1997;26:155 CD work_y6xvhkczvjdslpwrorji4thpga 65 3 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 65 4 164 164 CD work_y6xvhkczvjdslpwrorji4thpga 65 5 . . . work_y6xvhkczvjdslpwrorji4thpga 66 1 5 5 CD work_y6xvhkczvjdslpwrorji4thpga 66 2 . . . work_y6xvhkczvjdslpwrorji4thpga 67 1 Carlton Carlton NNP work_y6xvhkczvjdslpwrorji4thpga 67 2 VEH VEH NNP work_y6xvhkczvjdslpwrorji4thpga 67 3 , , , work_y6xvhkczvjdslpwrorji4thpga 67 4 Knisely Knisely NNP work_y6xvhkczvjdslpwrorji4thpga 67 5 AS AS NNP work_y6xvhkczvjdslpwrorji4thpga 67 6 , , , work_y6xvhkczvjdslpwrorji4thpga 67 7 Freimer Freimer NNP work_y6xvhkczvjdslpwrorji4thpga 67 8 NB NB NNP work_y6xvhkczvjdslpwrorji4thpga 67 9 . . . work_y6xvhkczvjdslpwrorji4thpga 68 1 Mapping map VBG work_y6xvhkczvjdslpwrorji4thpga 68 2 of of IN work_y6xvhkczvjdslpwrorji4thpga 68 3 a a DT work_y6xvhkczvjdslpwrorji4thpga 68 4 locus locus NN work_y6xvhkczvjdslpwrorji4thpga 68 5 for for IN work_y6xvhkczvjdslpwrorji4thpga 68 6 progres- progres- NN work_y6xvhkczvjdslpwrorji4thpga 68 7 sive sive JJ work_y6xvhkczvjdslpwrorji4thpga 68 8 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 68 9 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 68 10 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 68 11 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 68 12 Byler Byler NNP work_y6xvhkczvjdslpwrorji4thpga 68 13 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 68 14 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 68 15 to to IN work_y6xvhkczvjdslpwrorji4thpga 68 16 18q21-q22 18q21-q22 CD work_y6xvhkczvjdslpwrorji4thpga 68 17 the the DT work_y6xvhkczvjdslpwrorji4thpga 68 18 benign benign JJ work_y6xvhkczvjdslpwrorji4thpga 68 19 recurrent recurrent JJ work_y6xvhkczvjdslpwrorji4thpga 68 20 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 68 21 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 68 22 region region NN work_y6xvhkczvjdslpwrorji4thpga 68 23 . . . work_y6xvhkczvjdslpwrorji4thpga 69 1 Hum Hum NNP work_y6xvhkczvjdslpwrorji4thpga 69 2 Mol Mol NNP work_y6xvhkczvjdslpwrorji4thpga 69 3 Genet Genet NNP work_y6xvhkczvjdslpwrorji4thpga 69 4 1995;4:1049 1995;4:1049 CD work_y6xvhkczvjdslpwrorji4thpga 69 5 - - SYM work_y6xvhkczvjdslpwrorji4thpga 69 6 1053 1053 CD work_y6xvhkczvjdslpwrorji4thpga 69 7 . . . work_y6xvhkczvjdslpwrorji4thpga 70 1 6 6 CD work_y6xvhkczvjdslpwrorji4thpga 70 2 . . . work_y6xvhkczvjdslpwrorji4thpga 71 1 Houwen Houwen NNP work_y6xvhkczvjdslpwrorji4thpga 71 2 RHJ RHJ NNP work_y6xvhkczvjdslpwrorji4thpga 71 3 , , , work_y6xvhkczvjdslpwrorji4thpga 71 4 Baharloo Baharloo NNP work_y6xvhkczvjdslpwrorji4thpga 71 5 S S NNP work_y6xvhkczvjdslpwrorji4thpga 71 6 , , , work_y6xvhkczvjdslpwrorji4thpga 71 7 Blankenship Blankenship NNP work_y6xvhkczvjdslpwrorji4thpga 71 8 K K NNP work_y6xvhkczvjdslpwrorji4thpga 71 9 , , , work_y6xvhkczvjdslpwrorji4thpga 71 10 Raeymaekers Raeymaekers NNP work_y6xvhkczvjdslpwrorji4thpga 71 11 P P NNP work_y6xvhkczvjdslpwrorji4thpga 71 12 , , , work_y6xvhkczvjdslpwrorji4thpga 71 13 Juyn Juyn NNP work_y6xvhkczvjdslpwrorji4thpga 71 14 J J NNP work_y6xvhkczvjdslpwrorji4thpga 71 15 , , , work_y6xvhkczvjdslpwrorji4thpga 71 16 Sandkuijl Sandkuijl NNP work_y6xvhkczvjdslpwrorji4thpga 71 17 LA LA NNP work_y6xvhkczvjdslpwrorji4thpga 71 18 , , , work_y6xvhkczvjdslpwrorji4thpga 71 19 Freimer Freimer NNP work_y6xvhkczvjdslpwrorji4thpga 71 20 NB NB NNP work_y6xvhkczvjdslpwrorji4thpga 71 21 . . . work_y6xvhkczvjdslpwrorji4thpga 72 1 Genome genome JJ work_y6xvhkczvjdslpwrorji4thpga 72 2 screening screening NN work_y6xvhkczvjdslpwrorji4thpga 72 3 by by IN work_y6xvhkczvjdslpwrorji4thpga 72 4 searching search VBG work_y6xvhkczvjdslpwrorji4thpga 72 5 for for IN work_y6xvhkczvjdslpwrorji4thpga 72 6 shared shared JJ work_y6xvhkczvjdslpwrorji4thpga 72 7 segments segment NNS work_y6xvhkczvjdslpwrorji4thpga 72 8 : : : work_y6xvhkczvjdslpwrorji4thpga 72 9 mapping map VBG work_y6xvhkczvjdslpwrorji4thpga 72 10 a a DT work_y6xvhkczvjdslpwrorji4thpga 72 11 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 72 12 for for IN work_y6xvhkczvjdslpwrorji4thpga 72 13 benign benign JJ work_y6xvhkczvjdslpwrorji4thpga 72 14 recurrent recurrent JJ work_y6xvhkczvjdslpwrorji4thpga 72 15 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 72 16 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 72 17 . . . work_y6xvhkczvjdslpwrorji4thpga 73 1 Nat Nat NNP work_y6xvhkczvjdslpwrorji4thpga 73 2 Genet Genet NNP work_y6xvhkczvjdslpwrorji4thpga 73 3 1994;8:380 1994;8:380 CD work_y6xvhkczvjdslpwrorji4thpga 73 4 - - SYM work_y6xvhkczvjdslpwrorji4thpga 73 5 386 386 CD work_y6xvhkczvjdslpwrorji4thpga 73 6 . . . work_y6xvhkczvjdslpwrorji4thpga 74 1 7 7 LS work_y6xvhkczvjdslpwrorji4thpga 74 2 . . . work_y6xvhkczvjdslpwrorji4thpga 75 1 Maggiore Maggiore NNP work_y6xvhkczvjdslpwrorji4thpga 75 2 G G NNP work_y6xvhkczvjdslpwrorji4thpga 75 3 , , , work_y6xvhkczvjdslpwrorji4thpga 75 4 Bernard Bernard NNP work_y6xvhkczvjdslpwrorji4thpga 75 5 O O NNP work_y6xvhkczvjdslpwrorji4thpga 75 6 , , , work_y6xvhkczvjdslpwrorji4thpga 75 7 Hadchouel Hadchouel NNP work_y6xvhkczvjdslpwrorji4thpga 75 8 M M NNP work_y6xvhkczvjdslpwrorji4thpga 75 9 , , , work_y6xvhkczvjdslpwrorji4thpga 75 10 Lemonnier Lemonnier NNP work_y6xvhkczvjdslpwrorji4thpga 75 11 A A NNP work_y6xvhkczvjdslpwrorji4thpga 75 12 , , , work_y6xvhkczvjdslpwrorji4thpga 75 13 Alagille Alagille NNP work_y6xvhkczvjdslpwrorji4thpga 75 14 D. D. NNP work_y6xvhkczvjdslpwrorji4thpga 75 15 Diagnostic Diagnostic NNP work_y6xvhkczvjdslpwrorji4thpga 75 16 value value NN work_y6xvhkczvjdslpwrorji4thpga 75 17 of of IN work_y6xvhkczvjdslpwrorji4thpga 75 18 serum serum NNP work_y6xvhkczvjdslpwrorji4thpga 75 19 g g NNP work_y6xvhkczvjdslpwrorji4thpga 75 20 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 75 21 glutamyl glutamyl NNP work_y6xvhkczvjdslpwrorji4thpga 75 22 transpeptidase transpeptidase NN work_y6xvhkczvjdslpwrorji4thpga 75 23 activity activity NN work_y6xvhkczvjdslpwrorji4thpga 75 24 in in IN work_y6xvhkczvjdslpwrorji4thpga 75 25 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 75 26 diseases disease NNS work_y6xvhkczvjdslpwrorji4thpga 75 27 in in IN work_y6xvhkczvjdslpwrorji4thpga 75 28 children child NNS work_y6xvhkczvjdslpwrorji4thpga 75 29 . . . work_y6xvhkczvjdslpwrorji4thpga 76 1 J J NNP work_y6xvhkczvjdslpwrorji4thpga 76 2 Pediatr Pediatr NNP work_y6xvhkczvjdslpwrorji4thpga 76 3 Gastroenterol Gastroenterol NNP work_y6xvhkczvjdslpwrorji4thpga 76 4 Nutr Nutr NNP work_y6xvhkczvjdslpwrorji4thpga 76 5 1991;12:21 1991;12:21 CD work_y6xvhkczvjdslpwrorji4thpga 76 6 - - SYM work_y6xvhkczvjdslpwrorji4thpga 76 7 26 26 CD work_y6xvhkczvjdslpwrorji4thpga 76 8 . . . work_y6xvhkczvjdslpwrorji4thpga 77 1 8 8 LS work_y6xvhkczvjdslpwrorji4thpga 77 2 . . . work_y6xvhkczvjdslpwrorji4thpga 78 1 Smit smit VB work_y6xvhkczvjdslpwrorji4thpga 78 2 JJM JJM NNP work_y6xvhkczvjdslpwrorji4thpga 78 3 , , , work_y6xvhkczvjdslpwrorji4thpga 78 4 Schinkel Schinkel NNP work_y6xvhkczvjdslpwrorji4thpga 78 5 AH AH NNP work_y6xvhkczvjdslpwrorji4thpga 78 6 , , , work_y6xvhkczvjdslpwrorji4thpga 78 7 Oude Oude NNP work_y6xvhkczvjdslpwrorji4thpga 78 8 Elferink Elferink NNP work_y6xvhkczvjdslpwrorji4thpga 78 9 RPJ RPJ NNP work_y6xvhkczvjdslpwrorji4thpga 78 10 , , , work_y6xvhkczvjdslpwrorji4thpga 78 11 Groen Groen NNP work_y6xvhkczvjdslpwrorji4thpga 78 12 AK AK NNP work_y6xvhkczvjdslpwrorji4thpga 78 13 , , , work_y6xvhkczvjdslpwrorji4thpga 78 14 Wagenaar Wagenaar NNP work_y6xvhkczvjdslpwrorji4thpga 78 15 E E NNP work_y6xvhkczvjdslpwrorji4thpga 78 16 , , , work_y6xvhkczvjdslpwrorji4thpga 78 17 van van NNP work_y6xvhkczvjdslpwrorji4thpga 78 18 Deemter Deemter NNP work_y6xvhkczvjdslpwrorji4thpga 78 19 L L NNP work_y6xvhkczvjdslpwrorji4thpga 78 20 , , , work_y6xvhkczvjdslpwrorji4thpga 78 21 Mol Mol NNP work_y6xvhkczvjdslpwrorji4thpga 78 22 CAAM CAAM NNP work_y6xvhkczvjdslpwrorji4thpga 78 23 , , , work_y6xvhkczvjdslpwrorji4thpga 78 24 et et NNP work_y6xvhkczvjdslpwrorji4thpga 78 25 al al NNP work_y6xvhkczvjdslpwrorji4thpga 78 26 . . . work_y6xvhkczvjdslpwrorji4thpga 79 1 Homozygous homozygous JJ work_y6xvhkczvjdslpwrorji4thpga 79 2 disruption disruption NN work_y6xvhkczvjdslpwrorji4thpga 79 3 of of IN work_y6xvhkczvjdslpwrorji4thpga 79 4 the the DT work_y6xvhkczvjdslpwrorji4thpga 79 5 murine murine NN work_y6xvhkczvjdslpwrorji4thpga 79 6 mdr2 mdr2 NNP work_y6xvhkczvjdslpwrorji4thpga 79 7 P P NNP work_y6xvhkczvjdslpwrorji4thpga 79 8 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 79 9 glycoprotein glycoprotein NN work_y6xvhkczvjdslpwrorji4thpga 79 10 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 79 11 leads lead VBZ work_y6xvhkczvjdslpwrorji4thpga 79 12 to to IN work_y6xvhkczvjdslpwrorji4thpga 79 13 a a DT work_y6xvhkczvjdslpwrorji4thpga 79 14 complete complete JJ work_y6xvhkczvjdslpwrorji4thpga 79 15 absence absence NN work_y6xvhkczvjdslpwrorji4thpga 79 16 of of IN work_y6xvhkczvjdslpwrorji4thpga 79 17 phospholipid phospholipid NN work_y6xvhkczvjdslpwrorji4thpga 79 18 from from IN work_y6xvhkczvjdslpwrorji4thpga 79 19 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 79 20 and and CC work_y6xvhkczvjdslpwrorji4thpga 79 21 to to TO work_y6xvhkczvjdslpwrorji4thpga 79 22 liver liver VB work_y6xvhkczvjdslpwrorji4thpga 79 23 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 79 24 . . . work_y6xvhkczvjdslpwrorji4thpga 80 1 Cell Cell NNP work_y6xvhkczvjdslpwrorji4thpga 80 2 1993;75:451 1993;75:451 CD work_y6xvhkczvjdslpwrorji4thpga 80 3 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 80 4 462 462 CD work_y6xvhkczvjdslpwrorji4thpga 80 5 . . . work_y6xvhkczvjdslpwrorji4thpga 81 1 9 9 CD work_y6xvhkczvjdslpwrorji4thpga 81 2 . . . work_y6xvhkczvjdslpwrorji4thpga 82 1 Deleuze Deleuze NNP work_y6xvhkczvjdslpwrorji4thpga 82 2 J J NNP work_y6xvhkczvjdslpwrorji4thpga 82 3 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 82 4 F F NNP work_y6xvhkczvjdslpwrorji4thpga 82 5 , , , work_y6xvhkczvjdslpwrorji4thpga 82 6 Jacquemin Jacquemin NNP work_y6xvhkczvjdslpwrorji4thpga 82 7 E E NNP work_y6xvhkczvjdslpwrorji4thpga 82 8 , , , work_y6xvhkczvjdslpwrorji4thpga 82 9 Dubuisson Dubuisson NNP work_y6xvhkczvjdslpwrorji4thpga 82 10 C C NNP work_y6xvhkczvjdslpwrorji4thpga 82 11 , , , work_y6xvhkczvjdslpwrorji4thpga 82 12 Cresteil Cresteil NNP work_y6xvhkczvjdslpwrorji4thpga 82 13 D D NNP work_y6xvhkczvjdslpwrorji4thpga 82 14 , , , work_y6xvhkczvjdslpwrorji4thpga 82 15 Dumont Dumont NNP work_y6xvhkczvjdslpwrorji4thpga 82 16 M M NNP work_y6xvhkczvjdslpwrorji4thpga 82 17 , , , work_y6xvhkczvjdslpwrorji4thpga 82 18 Erlinger Erlinger NNP work_y6xvhkczvjdslpwrorji4thpga 82 19 S S NNP work_y6xvhkczvjdslpwrorji4thpga 82 20 , , , work_y6xvhkczvjdslpwrorji4thpga 82 21 Bernard Bernard NNP work_y6xvhkczvjdslpwrorji4thpga 82 22 O O NNP work_y6xvhkczvjdslpwrorji4thpga 82 23 , , , work_y6xvhkczvjdslpwrorji4thpga 82 24 Hadchouel Hadchouel NNP work_y6xvhkczvjdslpwrorji4thpga 82 25 M. M. NNP work_y6xvhkczvjdslpwrorji4thpga 82 26 Defect Defect NNP work_y6xvhkczvjdslpwrorji4thpga 82 27 of of IN work_y6xvhkczvjdslpwrorji4thpga 82 28 multidrug multidrug NN work_y6xvhkczvjdslpwrorji4thpga 82 29 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 82 30 resistance resistance NN work_y6xvhkczvjdslpwrorji4thpga 82 31 3 3 CD work_y6xvhkczvjdslpwrorji4thpga 82 32 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 82 33 expression expression NN work_y6xvhkczvjdslpwrorji4thpga 82 34 in in IN work_y6xvhkczvjdslpwrorji4thpga 82 35 a a DT work_y6xvhkczvjdslpwrorji4thpga 82 36 subtype subtype NN work_y6xvhkczvjdslpwrorji4thpga 82 37 of of IN work_y6xvhkczvjdslpwrorji4thpga 82 38 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 82 39 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 82 40 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 82 41 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 82 42 . . . work_y6xvhkczvjdslpwrorji4thpga 83 1 Hepatology hepatology NN work_y6xvhkczvjdslpwrorji4thpga 83 2 1996;23:904 1996;23:904 CD work_y6xvhkczvjdslpwrorji4thpga 83 3 - - SYM work_y6xvhkczvjdslpwrorji4thpga 83 4 908 908 CD work_y6xvhkczvjdslpwrorji4thpga 83 5 . . . work_y6xvhkczvjdslpwrorji4thpga 84 1 10 10 CD work_y6xvhkczvjdslpwrorji4thpga 84 2 . . . work_y6xvhkczvjdslpwrorji4thpga 85 1 Jacquemin Jacquemin NNP work_y6xvhkczvjdslpwrorji4thpga 85 2 E E NNP work_y6xvhkczvjdslpwrorji4thpga 85 3 , , , work_y6xvhkczvjdslpwrorji4thpga 85 4 Setchell Setchell NNP work_y6xvhkczvjdslpwrorji4thpga 85 5 KDR KDR NNP work_y6xvhkczvjdslpwrorji4thpga 85 6 , , , work_y6xvhkczvjdslpwrorji4thpga 85 7 O’Connell O’Connell NNP work_y6xvhkczvjdslpwrorji4thpga 85 8 NC NC NNP work_y6xvhkczvjdslpwrorji4thpga 85 9 , , , work_y6xvhkczvjdslpwrorji4thpga 85 10 Estrada Estrada NNP work_y6xvhkczvjdslpwrorji4thpga 85 11 A A NNP work_y6xvhkczvjdslpwrorji4thpga 85 12 , , , work_y6xvhkczvjdslpwrorji4thpga 85 13 Maggiore Maggiore NNP work_y6xvhkczvjdslpwrorji4thpga 85 14 G G NNP work_y6xvhkczvjdslpwrorji4thpga 85 15 , , , work_y6xvhkczvjdslpwrorji4thpga 85 16 Schmitz Schmitz NNP work_y6xvhkczvjdslpwrorji4thpga 85 17 J J NNP work_y6xvhkczvjdslpwrorji4thpga 85 18 , , , work_y6xvhkczvjdslpwrorji4thpga 85 19 Hadchouel Hadchouel NNP work_y6xvhkczvjdslpwrorji4thpga 85 20 M M NNP work_y6xvhkczvjdslpwrorji4thpga 85 21 , , , work_y6xvhkczvjdslpwrorji4thpga 85 22 et et NNP work_y6xvhkczvjdslpwrorji4thpga 85 23 al al NNP work_y6xvhkczvjdslpwrorji4thpga 85 24 . . . work_y6xvhkczvjdslpwrorji4thpga 86 1 A a DT work_y6xvhkczvjdslpwrorji4thpga 86 2 new new JJ work_y6xvhkczvjdslpwrorji4thpga 86 3 cause cause NN work_y6xvhkczvjdslpwrorji4thpga 86 4 of of IN work_y6xvhkczvjdslpwrorji4thpga 86 5 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 86 6 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 86 7 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 86 8 : : : work_y6xvhkczvjdslpwrorji4thpga 86 9 3b 3b JJ work_y6xvhkczvjdslpwrorji4thpga 86 10 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 86 11 hydroxy hydroxy NN work_y6xvhkczvjdslpwrorji4thpga 86 12 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 86 13 C27-steroid C27-steroid NNP work_y6xvhkczvjdslpwrorji4thpga 86 14 dehydrogenase dehydrogenase NN work_y6xvhkczvjdslpwrorji4thpga 86 15 / / SYM work_y6xvhkczvjdslpwrorji4thpga 86 16 isomerase isomerase JJ work_y6xvhkczvjdslpwrorji4thpga 86 17 defi- defi- JJ work_y6xvhkczvjdslpwrorji4thpga 86 18 ciency ciency NN work_y6xvhkczvjdslpwrorji4thpga 86 19 . . . work_y6xvhkczvjdslpwrorji4thpga 87 1 J J NNP work_y6xvhkczvjdslpwrorji4thpga 87 2 Pediatr Pediatr NNP work_y6xvhkczvjdslpwrorji4thpga 87 3 1994;125:379 1994;125:379 NNP work_y6xvhkczvjdslpwrorji4thpga 87 4 - - SYM work_y6xvhkczvjdslpwrorji4thpga 87 5 384 384 CD work_y6xvhkczvjdslpwrorji4thpga 87 6 . . . work_y6xvhkczvjdslpwrorji4thpga 88 1 11 11 CD work_y6xvhkczvjdslpwrorji4thpga 88 2 . . . work_y6xvhkczvjdslpwrorji4thpga 89 1 Jacquemin Jacquemin NNP work_y6xvhkczvjdslpwrorji4thpga 89 2 E E NNP work_y6xvhkczvjdslpwrorji4thpga 89 3 , , , work_y6xvhkczvjdslpwrorji4thpga 89 4 Dumont Dumont NNP work_y6xvhkczvjdslpwrorji4thpga 89 5 M M NNP work_y6xvhkczvjdslpwrorji4thpga 89 6 , , , work_y6xvhkczvjdslpwrorji4thpga 89 7 Bernard Bernard NNP work_y6xvhkczvjdslpwrorji4thpga 89 8 O O NNP work_y6xvhkczvjdslpwrorji4thpga 89 9 , , , work_y6xvhkczvjdslpwrorji4thpga 89 10 Erlinger Erlinger NNP work_y6xvhkczvjdslpwrorji4thpga 89 11 S S NNP work_y6xvhkczvjdslpwrorji4thpga 89 12 , , , work_y6xvhkczvjdslpwrorji4thpga 89 13 Hadchouel Hadchouel NNP work_y6xvhkczvjdslpwrorji4thpga 89 14 M. M. NNP work_y6xvhkczvjdslpwrorji4thpga 89 15 Evidence Evidence NNP work_y6xvhkczvjdslpwrorji4thpga 89 16 for for IN work_y6xvhkczvjdslpwrorji4thpga 89 17 defective defective JJ work_y6xvhkczvjdslpwrorji4thpga 89 18 primary primary JJ work_y6xvhkczvjdslpwrorji4thpga 89 19 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 89 20 acid acid NN work_y6xvhkczvjdslpwrorji4thpga 89 21 secretion secretion NN work_y6xvhkczvjdslpwrorji4thpga 89 22 in in IN work_y6xvhkczvjdslpwrorji4thpga 89 23 children child NNS work_y6xvhkczvjdslpwrorji4thpga 89 24 with with IN work_y6xvhkczvjdslpwrorji4thpga 89 25 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 89 26 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 89 27 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 89 28 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 89 29 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 89 30 Byler Byler NNP work_y6xvhkczvjdslpwrorji4thpga 89 31 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 89 32 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 89 33 . . . work_y6xvhkczvjdslpwrorji4thpga 90 1 Eur Eur NNP work_y6xvhkczvjdslpwrorji4thpga 90 2 J J NNP work_y6xvhkczvjdslpwrorji4thpga 90 3 Pediatr Pediatr NNP work_y6xvhkczvjdslpwrorji4thpga 90 4 1994;153 1994;153 CD work_y6xvhkczvjdslpwrorji4thpga 90 5 : : : work_y6xvhkczvjdslpwrorji4thpga 90 6 424 424 CD work_y6xvhkczvjdslpwrorji4thpga 90 7 - - SYM work_y6xvhkczvjdslpwrorji4thpga 90 8 428 428 CD work_y6xvhkczvjdslpwrorji4thpga 90 9 . . . work_y6xvhkczvjdslpwrorji4thpga 91 1 12 12 CD work_y6xvhkczvjdslpwrorji4thpga 91 2 . . . work_y6xvhkczvjdslpwrorji4thpga 92 1 Tang Tang NNP work_y6xvhkczvjdslpwrorji4thpga 92 2 X X NNP work_y6xvhkczvjdslpwrorji4thpga 92 3 , , , work_y6xvhkczvjdslpwrorji4thpga 92 4 Halleck Halleck NNP work_y6xvhkczvjdslpwrorji4thpga 92 5 MS MS NNP work_y6xvhkczvjdslpwrorji4thpga 92 6 , , , work_y6xvhkczvjdslpwrorji4thpga 92 7 Schlegel Schlegel NNP work_y6xvhkczvjdslpwrorji4thpga 92 8 RA RA NNP work_y6xvhkczvjdslpwrorji4thpga 92 9 , , , work_y6xvhkczvjdslpwrorji4thpga 92 10 Williamson Williamson NNP work_y6xvhkczvjdslpwrorji4thpga 92 11 P. P. NNP work_y6xvhkczvjdslpwrorji4thpga 92 12 A A NNP work_y6xvhkczvjdslpwrorji4thpga 92 13 subfamily subfamily NN work_y6xvhkczvjdslpwrorji4thpga 92 14 of of IN work_y6xvhkczvjdslpwrorji4thpga 92 15 P p NN work_y6xvhkczvjdslpwrorji4thpga 92 16 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 92 17 type type NN work_y6xvhkczvjdslpwrorji4thpga 92 18 ATPases atpase NNS work_y6xvhkczvjdslpwrorji4thpga 92 19 with with IN work_y6xvhkczvjdslpwrorji4thpga 92 20 aminophospholipid aminophospholipid NN work_y6xvhkczvjdslpwrorji4thpga 92 21 transporting transport VBG work_y6xvhkczvjdslpwrorji4thpga 92 22 activity activity NN work_y6xvhkczvjdslpwrorji4thpga 92 23 . . . work_y6xvhkczvjdslpwrorji4thpga 93 1 Science science NN work_y6xvhkczvjdslpwrorji4thpga 93 2 1996;272 1996;272 CD work_y6xvhkczvjdslpwrorji4thpga 93 3 : : : work_y6xvhkczvjdslpwrorji4thpga 93 4 1495 1495 CD work_y6xvhkczvjdslpwrorji4thpga 93 5 - - SYM work_y6xvhkczvjdslpwrorji4thpga 93 6 1497 1497 CD work_y6xvhkczvjdslpwrorji4thpga 93 7 . . . work_y6xvhkczvjdslpwrorji4thpga 94 1 HEPATOLOGY HEPATOLOGY NNP work_y6xvhkczvjdslpwrorji4thpga 94 2 Vol Vol NNP work_y6xvhkczvjdslpwrorji4thpga 94 3 . . . work_y6xvhkczvjdslpwrorji4thpga 95 1 28 28 CD work_y6xvhkczvjdslpwrorji4thpga 95 2 , , , work_y6xvhkczvjdslpwrorji4thpga 95 3 No no UH work_y6xvhkczvjdslpwrorji4thpga 95 4 . . . work_y6xvhkczvjdslpwrorji4thpga 96 1 3 3 CD work_y6xvhkczvjdslpwrorji4thpga 96 2 , , , work_y6xvhkczvjdslpwrorji4thpga 96 3 1998 1998 CD work_y6xvhkczvjdslpwrorji4thpga 96 4 HEPATOLOGY HEPATOLOGY NNP work_y6xvhkczvjdslpwrorji4thpga 96 5 Elsewhere Elsewhere NNP work_y6xvhkczvjdslpwrorji4thpga 96 6 889 889 CD work_y6xvhkczvjdslpwrorji4thpga 96 7 13 13 CD work_y6xvhkczvjdslpwrorji4thpga 96 8 . . . work_y6xvhkczvjdslpwrorji4thpga 97 1 Linarelli Linarelli NNP work_y6xvhkczvjdslpwrorji4thpga 97 2 LG LG NNP work_y6xvhkczvjdslpwrorji4thpga 97 3 , , , work_y6xvhkczvjdslpwrorji4thpga 97 4 Williams Williams NNP work_y6xvhkczvjdslpwrorji4thpga 97 5 CN CN NNP work_y6xvhkczvjdslpwrorji4thpga 97 6 , , , work_y6xvhkczvjdslpwrorji4thpga 97 7 Phillips Phillips NNP work_y6xvhkczvjdslpwrorji4thpga 97 8 MJ MJ NNP work_y6xvhkczvjdslpwrorji4thpga 97 9 . . . work_y6xvhkczvjdslpwrorji4thpga 98 1 Byler Byler NNP work_y6xvhkczvjdslpwrorji4thpga 98 2 ’s ’s POS work_y6xvhkczvjdslpwrorji4thpga 98 3 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 98 4 : : : work_y6xvhkczvjdslpwrorji4thpga 98 5 fatal fatal JJ work_y6xvhkczvjdslpwrorji4thpga 98 6 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 98 7 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 98 8 . . . work_y6xvhkczvjdslpwrorji4thpga 99 1 J J NNP work_y6xvhkczvjdslpwrorji4thpga 99 2 Pediatr Pediatr NNP work_y6xvhkczvjdslpwrorji4thpga 99 3 1972;81:484 1972;81:484 CD work_y6xvhkczvjdslpwrorji4thpga 99 4 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 99 5 492 492 CD work_y6xvhkczvjdslpwrorji4thpga 99 6 . . . work_y6xvhkczvjdslpwrorji4thpga 100 1 14 14 CD work_y6xvhkczvjdslpwrorji4thpga 100 2 . . . work_y6xvhkczvjdslpwrorji4thpga 101 1 Strautnieks Strautnieks NNP work_y6xvhkczvjdslpwrorji4thpga 101 2 SS SS NNP work_y6xvhkczvjdslpwrorji4thpga 101 3 , , , work_y6xvhkczvjdslpwrorji4thpga 101 4 Kagalwalla Kagalwalla NNP work_y6xvhkczvjdslpwrorji4thpga 101 5 AF AF NNP work_y6xvhkczvjdslpwrorji4thpga 101 6 , , , work_y6xvhkczvjdslpwrorji4thpga 101 7 Tanner Tanner NNP work_y6xvhkczvjdslpwrorji4thpga 101 8 MS MS NNP work_y6xvhkczvjdslpwrorji4thpga 101 9 , , , work_y6xvhkczvjdslpwrorji4thpga 101 10 Knisely Knisely NNP work_y6xvhkczvjdslpwrorji4thpga 101 11 AS AS NNP work_y6xvhkczvjdslpwrorji4thpga 101 12 , , , work_y6xvhkczvjdslpwrorji4thpga 101 13 Bull Bull NNP work_y6xvhkczvjdslpwrorji4thpga 101 14 L L NNP work_y6xvhkczvjdslpwrorji4thpga 101 15 , , , work_y6xvhkczvjdslpwrorji4thpga 101 16 Freimer Freimer NNP work_y6xvhkczvjdslpwrorji4thpga 101 17 N N NNP work_y6xvhkczvjdslpwrorji4thpga 101 18 , , , work_y6xvhkczvjdslpwrorji4thpga 101 19 Kocoshis Kocoshis NNP work_y6xvhkczvjdslpwrorji4thpga 101 20 SA SA NNP work_y6xvhkczvjdslpwrorji4thpga 101 21 , , , work_y6xvhkczvjdslpwrorji4thpga 101 22 et et NNP work_y6xvhkczvjdslpwrorji4thpga 101 23 al al NNP work_y6xvhkczvjdslpwrorji4thpga 101 24 . . . work_y6xvhkczvjdslpwrorji4thpga 102 1 Identification identification NN work_y6xvhkczvjdslpwrorji4thpga 102 2 of of IN work_y6xvhkczvjdslpwrorji4thpga 102 3 a a DT work_y6xvhkczvjdslpwrorji4thpga 102 4 locus locus NN work_y6xvhkczvjdslpwrorji4thpga 102 5 for for IN work_y6xvhkczvjdslpwrorji4thpga 102 6 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 102 7 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 102 8 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 102 9 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 102 10 PFIC2 pfic2 NN work_y6xvhkczvjdslpwrorji4thpga 102 11 on on IN work_y6xvhkczvjdslpwrorji4thpga 102 12 chromosome chromosome NN work_y6xvhkczvjdslpwrorji4thpga 102 13 2q24 2q24 CD work_y6xvhkczvjdslpwrorji4thpga 102 14 . . . work_y6xvhkczvjdslpwrorji4thpga 103 1 Am be VBP work_y6xvhkczvjdslpwrorji4thpga 103 2 J J NNP work_y6xvhkczvjdslpwrorji4thpga 103 3 Hum Hum NNP work_y6xvhkczvjdslpwrorji4thpga 103 4 Genet Genet NNP work_y6xvhkczvjdslpwrorji4thpga 103 5 1997;61:630 1997;61:630 CD work_y6xvhkczvjdslpwrorji4thpga 103 6 - - SYM work_y6xvhkczvjdslpwrorji4thpga 103 7 633 633 CD work_y6xvhkczvjdslpwrorji4thpga 103 8 . . . work_y6xvhkczvjdslpwrorji4thpga 104 1 15 15 CD work_y6xvhkczvjdslpwrorji4thpga 104 2 . . . work_y6xvhkczvjdslpwrorji4thpga 105 1 Thompson Thompson NNP work_y6xvhkczvjdslpwrorji4thpga 105 2 RJ RJ NNP work_y6xvhkczvjdslpwrorji4thpga 105 3 , , , work_y6xvhkczvjdslpwrorji4thpga 105 4 Strautnieks Strautnieks NNP work_y6xvhkczvjdslpwrorji4thpga 105 5 SS SS NNP work_y6xvhkczvjdslpwrorji4thpga 105 6 , , , work_y6xvhkczvjdslpwrorji4thpga 105 7 Kagalwalla Kagalwalla NNP work_y6xvhkczvjdslpwrorji4thpga 105 8 AF AF NNP work_y6xvhkczvjdslpwrorji4thpga 105 9 , , , work_y6xvhkczvjdslpwrorji4thpga 105 10 Tanner Tanner NNP work_y6xvhkczvjdslpwrorji4thpga 105 11 MS MS NNP work_y6xvhkczvjdslpwrorji4thpga 105 12 , , , work_y6xvhkczvjdslpwrorji4thpga 105 13 Knisely Knisely NNP work_y6xvhkczvjdslpwrorji4thpga 105 14 AS AS NNP work_y6xvhkczvjdslpwrorji4thpga 105 15 , , , work_y6xvhkczvjdslpwrorji4thpga 105 16 Bull Bull NNP work_y6xvhkczvjdslpwrorji4thpga 105 17 L L NNP work_y6xvhkczvjdslpwrorji4thpga 105 18 , , , work_y6xvhkczvjdslpwrorji4thpga 105 19 Freimer Freimer NNP work_y6xvhkczvjdslpwrorji4thpga 105 20 N N NNP work_y6xvhkczvjdslpwrorji4thpga 105 21 , , , work_y6xvhkczvjdslpwrorji4thpga 105 22 et et NNP work_y6xvhkczvjdslpwrorji4thpga 105 23 al al NNP work_y6xvhkczvjdslpwrorji4thpga 105 24 . . . work_y6xvhkczvjdslpwrorji4thpga 106 1 Identification identification NN work_y6xvhkczvjdslpwrorji4thpga 106 2 of of IN work_y6xvhkczvjdslpwrorji4thpga 106 3 a a DT work_y6xvhkczvjdslpwrorji4thpga 106 4 second second JJ work_y6xvhkczvjdslpwrorji4thpga 106 5 locus locus NN work_y6xvhkczvjdslpwrorji4thpga 106 6 for for IN work_y6xvhkczvjdslpwrorji4thpga 106 7 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 106 8 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 106 9 intrahepatic intrahepatic JJ work_y6xvhkczvjdslpwrorji4thpga 106 10 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 106 11 on on IN work_y6xvhkczvjdslpwrorji4thpga 106 12 chromosome chromosome NN work_y6xvhkczvjdslpwrorji4thpga 106 13 2q24 2q24 CD work_y6xvhkczvjdslpwrorji4thpga 106 14 [ [ -LRB- work_y6xvhkczvjdslpwrorji4thpga 106 15 Abstract Abstract NNP work_y6xvhkczvjdslpwrorji4thpga 106 16 ] ] -RRB- work_y6xvhkczvjdslpwrorji4thpga 106 17 . . . work_y6xvhkczvjdslpwrorji4thpga 107 1 HEPA- HEPA- NNP work_y6xvhkczvjdslpwrorji4thpga 107 2 TOLOGY tology CD work_y6xvhkczvjdslpwrorji4thpga 107 3 1997;26:383A. 1997;26:383a. CD work_y6xvhkczvjdslpwrorji4thpga 108 1 16 16 CD work_y6xvhkczvjdslpwrorji4thpga 108 2 . . . work_y6xvhkczvjdslpwrorji4thpga 109 1 Childs Childs NNP work_y6xvhkczvjdslpwrorji4thpga 109 2 S S NNP work_y6xvhkczvjdslpwrorji4thpga 109 3 , , , work_y6xvhkczvjdslpwrorji4thpga 109 4 Yeh Yeh NNP work_y6xvhkczvjdslpwrorji4thpga 109 5 RL RL NNP work_y6xvhkczvjdslpwrorji4thpga 109 6 , , , work_y6xvhkczvjdslpwrorji4thpga 109 7 Georges Georges NNP work_y6xvhkczvjdslpwrorji4thpga 109 8 E E NNP work_y6xvhkczvjdslpwrorji4thpga 109 9 , , , work_y6xvhkczvjdslpwrorji4thpga 109 10 Ling Ling NNP work_y6xvhkczvjdslpwrorji4thpga 109 11 V. V. NNP work_y6xvhkczvjdslpwrorji4thpga 109 12 Identification Identification NNP work_y6xvhkczvjdslpwrorji4thpga 109 13 of of IN work_y6xvhkczvjdslpwrorji4thpga 109 14 a a DT work_y6xvhkczvjdslpwrorji4thpga 109 15 sister sister NN work_y6xvhkczvjdslpwrorji4thpga 109 16 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 109 17 to to IN work_y6xvhkczvjdslpwrorji4thpga 109 18 P P NNP work_y6xvhkczvjdslpwrorji4thpga 109 19 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 109 20 glycoprotein glycoprotein NNP work_y6xvhkczvjdslpwrorji4thpga 109 21 . . . work_y6xvhkczvjdslpwrorji4thpga 110 1 Cancer cancer NN work_y6xvhkczvjdslpwrorji4thpga 110 2 Res Res NNP work_y6xvhkczvjdslpwrorji4thpga 110 3 1995;55:2029 1995;55:2029 CD work_y6xvhkczvjdslpwrorji4thpga 110 4 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 110 5 2034 2034 CD work_y6xvhkczvjdslpwrorji4thpga 110 6 . . . work_y6xvhkczvjdslpwrorji4thpga 111 1 17 17 CD work_y6xvhkczvjdslpwrorji4thpga 111 2 . . . work_y6xvhkczvjdslpwrorji4thpga 112 1 Gerloff Gerloff NNP work_y6xvhkczvjdslpwrorji4thpga 112 2 T T NNP work_y6xvhkczvjdslpwrorji4thpga 112 3 , , , work_y6xvhkczvjdslpwrorji4thpga 112 4 Stieger Stieger NNP work_y6xvhkczvjdslpwrorji4thpga 112 5 B B NNP work_y6xvhkczvjdslpwrorji4thpga 112 6 , , , work_y6xvhkczvjdslpwrorji4thpga 112 7 Hagenbuch Hagenbuch NNP work_y6xvhkczvjdslpwrorji4thpga 112 8 B B NNP work_y6xvhkczvjdslpwrorji4thpga 112 9 , , , work_y6xvhkczvjdslpwrorji4thpga 112 10 Madon Madon NNP work_y6xvhkczvjdslpwrorji4thpga 112 11 J J NNP work_y6xvhkczvjdslpwrorji4thpga 112 12 , , , work_y6xvhkczvjdslpwrorji4thpga 112 13 Landmann Landmann NNP work_y6xvhkczvjdslpwrorji4thpga 112 14 L L NNP work_y6xvhkczvjdslpwrorji4thpga 112 15 , , , work_y6xvhkczvjdslpwrorji4thpga 112 16 Roth Roth NNP work_y6xvhkczvjdslpwrorji4thpga 112 17 J J NNP work_y6xvhkczvjdslpwrorji4thpga 112 18 , , , work_y6xvhkczvjdslpwrorji4thpga 112 19 Hofmann Hofmann NNP work_y6xvhkczvjdslpwrorji4thpga 112 20 AF AF NNP work_y6xvhkczvjdslpwrorji4thpga 112 21 , , , work_y6xvhkczvjdslpwrorji4thpga 112 22 Meier Meier NNP work_y6xvhkczvjdslpwrorji4thpga 112 23 PJ PJ NNP work_y6xvhkczvjdslpwrorji4thpga 112 24 . . . work_y6xvhkczvjdslpwrorji4thpga 113 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 113 2 sister sister NN work_y6xvhkczvjdslpwrorji4thpga 113 3 P P NNP work_y6xvhkczvjdslpwrorji4thpga 113 4 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 113 5 glycoprotein glycoprotein NNP work_y6xvhkczvjdslpwrorji4thpga 113 6 represents represent VBZ work_y6xvhkczvjdslpwrorji4thpga 113 7 the the DT work_y6xvhkczvjdslpwrorji4thpga 113 8 canalicu- canalicu- NN work_y6xvhkczvjdslpwrorji4thpga 113 9 lar lar NNP work_y6xvhkczvjdslpwrorji4thpga 113 10 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 113 11 salt salt NN work_y6xvhkczvjdslpwrorji4thpga 113 12 export export NN work_y6xvhkczvjdslpwrorji4thpga 113 13 pump pump NN work_y6xvhkczvjdslpwrorji4thpga 113 14 of of IN work_y6xvhkczvjdslpwrorji4thpga 113 15 mammalian mammalian JJ work_y6xvhkczvjdslpwrorji4thpga 113 16 liver liver NN work_y6xvhkczvjdslpwrorji4thpga 113 17 . . . work_y6xvhkczvjdslpwrorji4thpga 114 1 ATP atp NN work_y6xvhkczvjdslpwrorji4thpga 114 2 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 114 3 dependent dependent JJ work_y6xvhkczvjdslpwrorji4thpga 114 4 taurocho- taurocho- NN work_y6xvhkczvjdslpwrorji4thpga 114 5 late late JJ work_y6xvhkczvjdslpwrorji4thpga 114 6 transport transport NN work_y6xvhkczvjdslpwrorji4thpga 114 7 . . . work_y6xvhkczvjdslpwrorji4thpga 115 1 J J NNP work_y6xvhkczvjdslpwrorji4thpga 115 2 Biol Biol NNP work_y6xvhkczvjdslpwrorji4thpga 115 3 Chem Chem NNP work_y6xvhkczvjdslpwrorji4thpga 115 4 1998;273:10046 1998;273:10046 NNP work_y6xvhkczvjdslpwrorji4thpga 115 5 - - SYM work_y6xvhkczvjdslpwrorji4thpga 115 6 10050 10050 CD work_y6xvhkczvjdslpwrorji4thpga 115 7 . . . work_y6xvhkczvjdslpwrorji4thpga 116 1 18 18 CD work_y6xvhkczvjdslpwrorji4thpga 116 2 . . . work_y6xvhkczvjdslpwrorji4thpga 117 1 Jansen Jansen NNP work_y6xvhkczvjdslpwrorji4thpga 117 2 P P NNP work_y6xvhkczvjdslpwrorji4thpga 117 3 , , , work_y6xvhkczvjdslpwrorji4thpga 117 4 Hooiveld Hooiveld NNP work_y6xvhkczvjdslpwrorji4thpga 117 5 G g NN work_y6xvhkczvjdslpwrorji4thpga 117 6 , , , work_y6xvhkczvjdslpwrorji4thpga 117 7 Koning Koning NNP work_y6xvhkczvjdslpwrorji4thpga 117 8 H H NNP work_y6xvhkczvjdslpwrorji4thpga 117 9 , , , work_y6xvhkczvjdslpwrorji4thpga 117 10 van van NNP work_y6xvhkczvjdslpwrorji4thpga 117 11 Goor Goor NNP work_y6xvhkczvjdslpwrorji4thpga 117 12 H H NNP work_y6xvhkczvjdslpwrorji4thpga 117 13 , , , work_y6xvhkczvjdslpwrorji4thpga 117 14 Gouw Gouw NNP work_y6xvhkczvjdslpwrorji4thpga 117 15 A A NNP work_y6xvhkczvjdslpwrorji4thpga 117 16 , , , work_y6xvhkczvjdslpwrorji4thpga 117 17 Kuipers Kuipers NNP work_y6xvhkczvjdslpwrorji4thpga 117 18 F F NNP work_y6xvhkczvjdslpwrorji4thpga 117 19 , , , work_y6xvhkczvjdslpwrorji4thpga 117 20 Bijleveld Bijleveld NNP work_y6xvhkczvjdslpwrorji4thpga 117 21 C C NNP work_y6xvhkczvjdslpwrorji4thpga 117 22 , , , work_y6xvhkczvjdslpwrorji4thpga 117 23 et et NNP work_y6xvhkczvjdslpwrorji4thpga 117 24 al al NNP work_y6xvhkczvjdslpwrorji4thpga 117 25 . . . work_y6xvhkczvjdslpwrorji4thpga 118 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 118 2 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 118 3 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 118 4 , , , work_y6xvhkczvjdslpwrorji4thpga 118 5 encoding encode VBG work_y6xvhkczvjdslpwrorji4thpga 118 6 the the DT work_y6xvhkczvjdslpwrorji4thpga 118 7 canalicular canalicular JJ work_y6xvhkczvjdslpwrorji4thpga 118 8 bile bile NN work_y6xvhkczvjdslpwrorji4thpga 118 9 acid acid NN work_y6xvhkczvjdslpwrorji4thpga 118 10 transporting transport VBG work_y6xvhkczvjdslpwrorji4thpga 118 11 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 118 12 SPGP SPGP NNP work_y6xvhkczvjdslpwrorji4thpga 118 13 / / SYM work_y6xvhkczvjdslpwrorji4thpga 118 14 cBST cbst NN work_y6xvhkczvjdslpwrorji4thpga 118 15 , , , work_y6xvhkczvjdslpwrorji4thpga 118 16 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 118 17 not not RB work_y6xvhkczvjdslpwrorji4thpga 118 18 expressed express VBN work_y6xvhkczvjdslpwrorji4thpga 118 19 in in IN work_y6xvhkczvjdslpwrorji4thpga 118 20 a a DT work_y6xvhkczvjdslpwrorji4thpga 118 21 subgroup subgroup NN work_y6xvhkczvjdslpwrorji4thpga 118 22 of of IN work_y6xvhkczvjdslpwrorji4thpga 118 23 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 118 24 with with IN work_y6xvhkczvjdslpwrorji4thpga 118 25 progressive progressive JJ work_y6xvhkczvjdslpwrorji4thpga 118 26 familial familial JJ work_y6xvhkczvjdslpwrorji4thpga 118 27 cholestasis cholestasis NN work_y6xvhkczvjdslpwrorji4thpga 118 28 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 118 29 PFIC-2 pfic-2 NN work_y6xvhkczvjdslpwrorji4thpga 118 30 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 118 31 . . . work_y6xvhkczvjdslpwrorji4thpga 119 1 J J NNP work_y6xvhkczvjdslpwrorji4thpga 119 2 Hepatol Hepatol NNP work_y6xvhkczvjdslpwrorji4thpga 119 3 1998 1998 CD work_y6xvhkczvjdslpwrorji4thpga 119 4 ; ; : work_y6xvhkczvjdslpwrorji4thpga 119 5 28:42 28:42 CD work_y6xvhkczvjdslpwrorji4thpga 119 6 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 119 7 suppl suppl NN work_y6xvhkczvjdslpwrorji4thpga 119 8 1 1 CD work_y6xvhkczvjdslpwrorji4thpga 119 9 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 119 10 . . . work_y6xvhkczvjdslpwrorji4thpga 120 1 19 19 CD work_y6xvhkczvjdslpwrorji4thpga 120 2 . . . work_y6xvhkczvjdslpwrorji4thpga 121 1 Lammert Lammert NNP work_y6xvhkczvjdslpwrorji4thpga 121 2 F F NNP work_y6xvhkczvjdslpwrorji4thpga 121 3 , , , work_y6xvhkczvjdslpwrorji4thpga 121 4 Beier Beier NNP work_y6xvhkczvjdslpwrorji4thpga 121 5 DR DR NNP work_y6xvhkczvjdslpwrorji4thpga 121 6 , , , work_y6xvhkczvjdslpwrorji4thpga 121 7 Wang Wang NNP work_y6xvhkczvjdslpwrorji4thpga 121 8 DOH DOH NNP work_y6xvhkczvjdslpwrorji4thpga 121 9 , , , work_y6xvhkczvjdslpwrorji4thpga 121 10 Carey Carey NNP work_y6xvhkczvjdslpwrorji4thpga 121 11 MC MC NNP work_y6xvhkczvjdslpwrorji4thpga 121 12 , , , work_y6xvhkczvjdslpwrorji4thpga 121 13 Paigen Paigen NNP work_y6xvhkczvjdslpwrorji4thpga 121 14 B B NNP work_y6xvhkczvjdslpwrorji4thpga 121 15 , , , work_y6xvhkczvjdslpwrorji4thpga 121 16 Cohen Cohen NNP work_y6xvhkczvjdslpwrorji4thpga 121 17 DE DE NNP work_y6xvhkczvjdslpwrorji4thpga 121 18 . . . work_y6xvhkczvjdslpwrorji4thpga 122 1 Genetic genetic JJ work_y6xvhkczvjdslpwrorji4thpga 122 2 mapping mapping NN work_y6xvhkczvjdslpwrorji4thpga 122 3 of of IN work_y6xvhkczvjdslpwrorji4thpga 122 4 hepatocanalicular hepatocanalicular JJ work_y6xvhkczvjdslpwrorji4thpga 122 5 transporters transporters NNP work_y6xvhkczvjdslpwrorji4thpga 122 6 establishes establish VBZ work_y6xvhkczvjdslpwrorji4thpga 122 7 sister sister NNP work_y6xvhkczvjdslpwrorji4thpga 122 8 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 122 9 P- P- NNP work_y6xvhkczvjdslpwrorji4thpga 122 10 glycoprotein glycoprotein NNP work_y6xvhkczvjdslpwrorji4thpga 122 11 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 122 12 spgp spgp NNP work_y6xvhkczvjdslpwrorji4thpga 122 13 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 122 14 as as IN work_y6xvhkczvjdslpwrorji4thpga 122 15 a a DT work_y6xvhkczvjdslpwrorji4thpga 122 16 candidate candidate NN work_y6xvhkczvjdslpwrorji4thpga 122 17 for for IN work_y6xvhkczvjdslpwrorji4thpga 122 18 the the DT work_y6xvhkczvjdslpwrorji4thpga 122 19 major major JJ work_y6xvhkczvjdslpwrorji4thpga 122 20 gallstone gallstone NN work_y6xvhkczvjdslpwrorji4thpga 122 21 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 122 22 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 122 23 Lith1 Lith1 NNP work_y6xvhkczvjdslpwrorji4thpga 122 24 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 122 25 . . . work_y6xvhkczvjdslpwrorji4thpga 123 1 HEPATOLOGY HEPATOLOGY NNP work_y6xvhkczvjdslpwrorji4thpga 123 2 1997;26:358A 1997;26:358a CD work_y6xvhkczvjdslpwrorji4thpga 123 3 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 123 4 suppl suppl NN work_y6xvhkczvjdslpwrorji4thpga 123 5 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 123 6 . . . work_y6xvhkczvjdslpwrorji4thpga 124 1 HEREDITARY HEREDITARY NNP work_y6xvhkczvjdslpwrorji4thpga 124 2 HEMOCHROMATOSIS hemochromatosi NNS work_y6xvhkczvjdslpwrorji4thpga 124 3 — — : work_y6xvhkczvjdslpwrorji4thpga 124 4 SOMETIMES sometimes RB work_y6xvhkczvjdslpwrorji4thpga 124 5 HAVING have VBG work_y6xvhkczvjdslpwrorji4thpga 124 6 A a DT work_y6xvhkczvjdslpwrorji4thpga 124 7 REAL real JJ work_y6xvhkczvjdslpwrorji4thpga 124 8 COMPLEX complex NN work_y6xvhkczvjdslpwrorji4thpga 124 9 CAN CAN MD work_y6xvhkczvjdslpwrorji4thpga 124 10 BE be VB work_y6xvhkczvjdslpwrorji4thpga 124 11 A a DT work_y6xvhkczvjdslpwrorji4thpga 124 12 GOOD good JJ work_y6xvhkczvjdslpwrorji4thpga 124 13 THING thing NN work_y6xvhkczvjdslpwrorji4thpga 124 14 Feder fed JJR work_y6xvhkczvjdslpwrorji4thpga 124 15 JN JN NNP work_y6xvhkczvjdslpwrorji4thpga 124 16 , , , work_y6xvhkczvjdslpwrorji4thpga 124 17 Penny Penny NNP work_y6xvhkczvjdslpwrorji4thpga 124 18 DM DM NNP work_y6xvhkczvjdslpwrorji4thpga 124 19 , , , work_y6xvhkczvjdslpwrorji4thpga 124 20 Irrinki Irrinki NNP work_y6xvhkczvjdslpwrorji4thpga 124 21 A A NNP work_y6xvhkczvjdslpwrorji4thpga 124 22 , , , work_y6xvhkczvjdslpwrorji4thpga 124 23 Lee Lee NNP work_y6xvhkczvjdslpwrorji4thpga 124 24 VK VK NNP work_y6xvhkczvjdslpwrorji4thpga 124 25 , , , work_y6xvhkczvjdslpwrorji4thpga 124 26 Lebron Lebron NNP work_y6xvhkczvjdslpwrorji4thpga 124 27 JA JA NNP work_y6xvhkczvjdslpwrorji4thpga 124 28 , , , work_y6xvhkczvjdslpwrorji4thpga 124 29 Watson Watson NNP work_y6xvhkczvjdslpwrorji4thpga 124 30 N N NNP work_y6xvhkczvjdslpwrorji4thpga 124 31 , , , work_y6xvhkczvjdslpwrorji4thpga 124 32 Tsuchihashi Tsuchihashi NNP work_y6xvhkczvjdslpwrorji4thpga 124 33 Z Z NNP work_y6xvhkczvjdslpwrorji4thpga 124 34 , , , work_y6xvhkczvjdslpwrorji4thpga 124 35 Sigal Sigal NNP work_y6xvhkczvjdslpwrorji4thpga 124 36 E E NNP work_y6xvhkczvjdslpwrorji4thpga 124 37 , , , work_y6xvhkczvjdslpwrorji4thpga 124 38 Bjorkman Bjorkman NNP work_y6xvhkczvjdslpwrorji4thpga 124 39 PJ PJ NNP work_y6xvhkczvjdslpwrorji4thpga 124 40 , , , work_y6xvhkczvjdslpwrorji4thpga 124 41 Schatzman Schatzman NNP work_y6xvhkczvjdslpwrorji4thpga 124 42 RC RC NNP work_y6xvhkczvjdslpwrorji4thpga 124 43 . . . work_y6xvhkczvjdslpwrorji4thpga 125 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 125 2 hemochromatosis hemochromatosis NN work_y6xvhkczvjdslpwrorji4thpga 125 3 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 125 4 product product NN work_y6xvhkczvjdslpwrorji4thpga 125 5 complexes complex NNS work_y6xvhkczvjdslpwrorji4thpga 125 6 with with IN work_y6xvhkczvjdslpwrorji4thpga 125 7 the the DT work_y6xvhkczvjdslpwrorji4thpga 125 8 transfer- transfer- NNP work_y6xvhkczvjdslpwrorji4thpga 125 9 rin rin NN work_y6xvhkczvjdslpwrorji4thpga 125 10 receptor receptor NN work_y6xvhkczvjdslpwrorji4thpga 125 11 and and CC work_y6xvhkczvjdslpwrorji4thpga 125 12 lowers lower VBZ work_y6xvhkczvjdslpwrorji4thpga 125 13 its -PRON- PRP$ work_y6xvhkczvjdslpwrorji4thpga 125 14 affinity affinity NN work_y6xvhkczvjdslpwrorji4thpga 125 15 for for IN work_y6xvhkczvjdslpwrorji4thpga 125 16 ligand ligand NN work_y6xvhkczvjdslpwrorji4thpga 125 17 binding binding NN work_y6xvhkczvjdslpwrorji4thpga 125 18 . . . work_y6xvhkczvjdslpwrorji4thpga 126 1 Proc Proc NNP work_y6xvhkczvjdslpwrorji4thpga 126 2 Natl Natl NNP work_y6xvhkczvjdslpwrorji4thpga 126 3 Acad Acad NNP work_y6xvhkczvjdslpwrorji4thpga 126 4 Sci Sci NNP work_y6xvhkczvjdslpwrorji4thpga 126 5 U U NNP work_y6xvhkczvjdslpwrorji4thpga 126 6 S S NNP work_y6xvhkczvjdslpwrorji4thpga 126 7 A A NNP work_y6xvhkczvjdslpwrorji4thpga 126 8 1998;95:1472 1998;95:1472 CD work_y6xvhkczvjdslpwrorji4thpga 126 9 - - SYM work_y6xvhkczvjdslpwrorji4thpga 126 10 1477 1477 CD work_y6xvhkczvjdslpwrorji4thpga 126 11 . . . work_y6xvhkczvjdslpwrorji4thpga 127 1 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 127 2 Reprinted reprint VBN work_y6xvhkczvjdslpwrorji4thpga 127 3 with with IN work_y6xvhkczvjdslpwrorji4thpga 127 4 permission permission NN work_y6xvhkczvjdslpwrorji4thpga 127 5 . . . work_y6xvhkczvjdslpwrorji4thpga 127 6 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 128 1 ABSTRACT ABSTRACT NNP work_y6xvhkczvjdslpwrorji4thpga 128 2 We -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 128 3 recently recently RB work_y6xvhkczvjdslpwrorji4thpga 128 4 reported report VBD work_y6xvhkczvjdslpwrorji4thpga 128 5 the the DT work_y6xvhkczvjdslpwrorji4thpga 128 6 positional positional JJ work_y6xvhkczvjdslpwrorji4thpga 128 7 cloning cloning NN work_y6xvhkczvjdslpwrorji4thpga 128 8 of of IN work_y6xvhkczvjdslpwrorji4thpga 128 9 a a DT work_y6xvhkczvjdslpwrorji4thpga 128 10 candi- candi- JJ work_y6xvhkczvjdslpwrorji4thpga 128 11 date date NN work_y6xvhkczvjdslpwrorji4thpga 128 12 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 128 13 for for IN work_y6xvhkczvjdslpwrorji4thpga 128 14 hereditary hereditary JJ work_y6xvhkczvjdslpwrorji4thpga 128 15 hemochromatosis hemochromatosis NN work_y6xvhkczvjdslpwrorji4thpga 128 16 called call VBN work_y6xvhkczvjdslpwrorji4thpga 128 17 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 128 18 . . . work_y6xvhkczvjdslpwrorji4thpga 129 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 129 2 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 129 3 product product NN work_y6xvhkczvjdslpwrorji4thpga 129 4 , , , work_y6xvhkczvjdslpwrorji4thpga 129 5 a a DT work_y6xvhkczvjdslpwrorji4thpga 129 6 member member NN work_y6xvhkczvjdslpwrorji4thpga 129 7 of of IN work_y6xvhkczvjdslpwrorji4thpga 129 8 the the DT work_y6xvhkczvjdslpwrorji4thpga 129 9 major major JJ work_y6xvhkczvjdslpwrorji4thpga 129 10 histocompatibility histocompatibility NN work_y6xvhkczvjdslpwrorji4thpga 129 11 complex complex JJ work_y6xvhkczvjdslpwrorji4thpga 129 12 class class NN work_y6xvhkczvjdslpwrorji4thpga 129 13 I i NN work_y6xvhkczvjdslpwrorji4thpga 129 14 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 129 15 like like JJ work_y6xvhkczvjdslpwrorji4thpga 129 16 family family NN work_y6xvhkczvjdslpwrorji4thpga 129 17 , , , work_y6xvhkczvjdslpwrorji4thpga 129 18 was be VBD work_y6xvhkczvjdslpwrorji4thpga 129 19 found find VBN work_y6xvhkczvjdslpwrorji4thpga 129 20 to to TO work_y6xvhkczvjdslpwrorji4thpga 129 21 have have VB work_y6xvhkczvjdslpwrorji4thpga 129 22 a a DT work_y6xvhkczvjdslpwrorji4thpga 129 23 mutation mutation NN work_y6xvhkczvjdslpwrorji4thpga 129 24 , , , work_y6xvhkczvjdslpwrorji4thpga 129 25 Cys-282 cys-282 CD work_y6xvhkczvjdslpwrorji4thpga 129 26 Tyr Tyr NNP work_y6xvhkczvjdslpwrorji4thpga 129 27 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 129 28 C282Y C282Y NNP work_y6xvhkczvjdslpwrorji4thpga 129 29 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 129 30 , , , work_y6xvhkczvjdslpwrorji4thpga 129 31 in in IN work_y6xvhkczvjdslpwrorji4thpga 129 32 85 85 CD work_y6xvhkczvjdslpwrorji4thpga 129 33 % % NN work_y6xvhkczvjdslpwrorji4thpga 129 34 of of IN work_y6xvhkczvjdslpwrorji4thpga 129 35 patient patient JJ work_y6xvhkczvjdslpwrorji4thpga 129 36 chromosomes chromosome NNS work_y6xvhkczvjdslpwrorji4thpga 129 37 . . . work_y6xvhkczvjdslpwrorji4thpga 130 1 This this DT work_y6xvhkczvjdslpwrorji4thpga 130 2 mutation mutation NN work_y6xvhkczvjdslpwrorji4thpga 130 3 eliminates eliminate VBZ work_y6xvhkczvjdslpwrorji4thpga 130 4 the the DT work_y6xvhkczvjdslpwrorji4thpga 130 5 ability ability NN work_y6xvhkczvjdslpwrorji4thpga 130 6 of of IN work_y6xvhkczvjdslpwrorji4thpga 130 7 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 130 8 to to TO work_y6xvhkczvjdslpwrorji4thpga 130 9 associate associate VB work_y6xvhkczvjdslpwrorji4thpga 130 10 with with IN work_y6xvhkczvjdslpwrorji4thpga 130 11 b2-microglobulin b2-microglobulin NNP work_y6xvhkczvjdslpwrorji4thpga 130 12 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 130 13 b2 b2 NNP work_y6xvhkczvjdslpwrorji4thpga 130 14 m m NNP work_y6xvhkczvjdslpwrorji4thpga 130 15 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 130 16 and and CC work_y6xvhkczvjdslpwrorji4thpga 130 17 prevents prevent VBZ work_y6xvhkczvjdslpwrorji4thpga 130 18 cell cell NN work_y6xvhkczvjdslpwrorji4thpga 130 19 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 130 20 surface surface NN work_y6xvhkczvjdslpwrorji4thpga 130 21 expres- expres- VBZ work_y6xvhkczvjdslpwrorji4thpga 130 22 sion sion NN work_y6xvhkczvjdslpwrorji4thpga 130 23 . . . work_y6xvhkczvjdslpwrorji4thpga 131 1 A a DT work_y6xvhkczvjdslpwrorji4thpga 131 2 second second JJ work_y6xvhkczvjdslpwrorji4thpga 131 3 mutation mutation NN work_y6xvhkczvjdslpwrorji4thpga 131 4 that that WDT work_y6xvhkczvjdslpwrorji4thpga 131 5 has have VBZ work_y6xvhkczvjdslpwrorji4thpga 131 6 no no DT work_y6xvhkczvjdslpwrorji4thpga 131 7 effect effect NN work_y6xvhkczvjdslpwrorji4thpga 131 8 on on IN work_y6xvhkczvjdslpwrorji4thpga 131 9 b2 b2 NNP work_y6xvhkczvjdslpwrorji4thpga 131 10 m m NNP work_y6xvhkczvjdslpwrorji4thpga 131 11 associa- associa- NNP work_y6xvhkczvjdslpwrorji4thpga 131 12 tion tion NN work_y6xvhkczvjdslpwrorji4thpga 131 13 , , , work_y6xvhkczvjdslpwrorji4thpga 131 14 H63D H63D NNP work_y6xvhkczvjdslpwrorji4thpga 131 15 , , , work_y6xvhkczvjdslpwrorji4thpga 131 16 was be VBD work_y6xvhkczvjdslpwrorji4thpga 131 17 found find VBN work_y6xvhkczvjdslpwrorji4thpga 131 18 in in IN work_y6xvhkczvjdslpwrorji4thpga 131 19 eight eight CD work_y6xvhkczvjdslpwrorji4thpga 131 20 out out IN work_y6xvhkczvjdslpwrorji4thpga 131 21 of of IN work_y6xvhkczvjdslpwrorji4thpga 131 22 nine nine CD work_y6xvhkczvjdslpwrorji4thpga 131 23 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 131 24 heterozygous heterozygous JJ work_y6xvhkczvjdslpwrorji4thpga 131 25 for for IN work_y6xvhkczvjdslpwrorji4thpga 131 26 the the DT work_y6xvhkczvjdslpwrorji4thpga 131 27 C282Y C282Y NNP work_y6xvhkczvjdslpwrorji4thpga 131 28 mutant mutant NN work_y6xvhkczvjdslpwrorji4thpga 131 29 . . . work_y6xvhkczvjdslpwrorji4thpga 132 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 132 2 this this DT work_y6xvhkczvjdslpwrorji4thpga 132 3 report report NN work_y6xvhkczvjdslpwrorji4thpga 132 4 , , , work_y6xvhkczvjdslpwrorji4thpga 132 5 we -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 132 6 demonstrate demonstrate VBP work_y6xvhkczvjdslpwrorji4thpga 132 7 in in IN work_y6xvhkczvjdslpwrorji4thpga 132 8 cultured cultured JJ work_y6xvhkczvjdslpwrorji4thpga 132 9 293 293 CD work_y6xvhkczvjdslpwrorji4thpga 132 10 cells cell NNS work_y6xvhkczvjdslpwrorji4thpga 132 11 overexpressing overexpresse VBG work_y6xvhkczvjdslpwrorji4thpga 132 12 wild wild JJ work_y6xvhkczvjdslpwrorji4thpga 132 13 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 132 14 type type NN work_y6xvhkczvjdslpwrorji4thpga 132 15 or or CC work_y6xvhkczvjdslpwrorji4thpga 132 16 mutant mutant JJ work_y6xvhkczvjdslpwrorji4thpga 132 17 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 132 18 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 132 19 that that IN work_y6xvhkczvjdslpwrorji4thpga 132 20 both both CC work_y6xvhkczvjdslpwrorji4thpga 132 21 the the DT work_y6xvhkczvjdslpwrorji4thpga 132 22 wild wild JJ work_y6xvhkczvjdslpwrorji4thpga 132 23 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 132 24 type type NN work_y6xvhkczvjdslpwrorji4thpga 132 25 and and CC work_y6xvhkczvjdslpwrorji4thpga 132 26 H63D H63D NNP work_y6xvhkczvjdslpwrorji4thpga 132 27 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 132 28 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 132 29 form form VBP work_y6xvhkczvjdslpwrorji4thpga 132 30 stable stable JJ work_y6xvhkczvjdslpwrorji4thpga 132 31 complexes complex NNS work_y6xvhkczvjdslpwrorji4thpga 132 32 with with IN work_y6xvhkczvjdslpwrorji4thpga 132 33 the the DT work_y6xvhkczvjdslpwrorji4thpga 132 34 transferrin transferrin NN work_y6xvhkczvjdslpwrorji4thpga 132 35 receptor receptor NN work_y6xvhkczvjdslpwrorji4thpga 132 36 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 132 37 TfR TfR NNP work_y6xvhkczvjdslpwrorji4thpga 132 38 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 132 39 . . . work_y6xvhkczvjdslpwrorji4thpga 133 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 133 2 C282Y c282y CD work_y6xvhkczvjdslpwrorji4thpga 133 3 mutation mutation NN work_y6xvhkczvjdslpwrorji4thpga 133 4 nearly nearly RB work_y6xvhkczvjdslpwrorji4thpga 133 5 completely completely RB work_y6xvhkczvjdslpwrorji4thpga 133 6 prevents prevent VBZ work_y6xvhkczvjdslpwrorji4thpga 133 7 the the DT work_y6xvhkczvjdslpwrorji4thpga 133 8 association association NN work_y6xvhkczvjdslpwrorji4thpga 133 9 of of IN work_y6xvhkczvjdslpwrorji4thpga 133 10 the the DT work_y6xvhkczvjdslpwrorji4thpga 133 11 mutant mutant JJ work_y6xvhkczvjdslpwrorji4thpga 133 12 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 133 13 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 133 14 with with IN work_y6xvhkczvjdslpwrorji4thpga 133 15 the the DT work_y6xvhkczvjdslpwrorji4thpga 133 16 TfR. TfR. NNP work_y6xvhkczvjdslpwrorji4thpga 134 1 Studies study NNS work_y6xvhkczvjdslpwrorji4thpga 134 2 on on IN work_y6xvhkczvjdslpwrorji4thpga 134 3 cell cell NN work_y6xvhkczvjdslpwrorji4thpga 134 4 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 134 5 associated associate VBN work_y6xvhkczvjdslpwrorji4thpga 134 6 transferrin transferrin NN work_y6xvhkczvjdslpwrorji4thpga 134 7 at at IN work_y6xvhkczvjdslpwrorji4thpga 134 8 377C 377c CD work_y6xvhkczvjdslpwrorji4thpga 134 9 suggest suggest VBP work_y6xvhkczvjdslpwrorji4thpga 134 10 that that IN work_y6xvhkczvjdslpwrorji4thpga 134 11 the the DT work_y6xvhkczvjdslpwrorji4thpga 134 12 overexpressed overexpresse VBN work_y6xvhkczvjdslpwrorji4thpga 134 13 wild wild JJ work_y6xvhkczvjdslpwrorji4thpga 134 14 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 134 15 type type NN work_y6xvhkczvjdslpwrorji4thpga 134 16 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 134 17 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 134 18 decreases decrease VBZ work_y6xvhkczvjdslpwrorji4thpga 134 19 the the DT work_y6xvhkczvjdslpwrorji4thpga 134 20 affinity affinity NN work_y6xvhkczvjdslpwrorji4thpga 134 21 of of IN work_y6xvhkczvjdslpwrorji4thpga 134 22 the the DT work_y6xvhkczvjdslpwrorji4thpga 134 23 TfR TfR NNP work_y6xvhkczvjdslpwrorji4thpga 134 24 for for IN work_y6xvhkczvjdslpwrorji4thpga 134 25 transferrin transferrin NNP work_y6xvhkczvjdslpwrorji4thpga 134 26 . . . work_y6xvhkczvjdslpwrorji4thpga 135 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 135 2 overexpressed overexpressed JJ work_y6xvhkczvjdslpwrorji4thpga 135 3 H63D H63D NNP work_y6xvhkczvjdslpwrorji4thpga 135 4 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 135 5 does do VBZ work_y6xvhkczvjdslpwrorji4thpga 135 6 not not RB work_y6xvhkczvjdslpwrorji4thpga 135 7 have have VB work_y6xvhkczvjdslpwrorji4thpga 135 8 this this DT work_y6xvhkczvjdslpwrorji4thpga 135 9 effect effect NN work_y6xvhkczvjdslpwrorji4thpga 135 10 , , , work_y6xvhkczvjdslpwrorji4thpga 135 11 providing provide VBG work_y6xvhkczvjdslpwrorji4thpga 135 12 the the DT work_y6xvhkczvjdslpwrorji4thpga 135 13 first first JJ work_y6xvhkczvjdslpwrorji4thpga 135 14 direct direct JJ work_y6xvhkczvjdslpwrorji4thpga 135 15 evidence evidence NN work_y6xvhkczvjdslpwrorji4thpga 135 16 for for IN work_y6xvhkczvjdslpwrorji4thpga 135 17 a a DT work_y6xvhkczvjdslpwrorji4thpga 135 18 functional functional JJ work_y6xvhkczvjdslpwrorji4thpga 135 19 consequence consequence NN work_y6xvhkczvjdslpwrorji4thpga 135 20 of of IN work_y6xvhkczvjdslpwrorji4thpga 135 21 the the DT work_y6xvhkczvjdslpwrorji4thpga 135 22 H63D H63D NNP work_y6xvhkczvjdslpwrorji4thpga 135 23 muta- muta- NN work_y6xvhkczvjdslpwrorji4thpga 135 24 tion tion NN work_y6xvhkczvjdslpwrorji4thpga 135 25 . . . work_y6xvhkczvjdslpwrorji4thpga 136 1 Addition addition NN work_y6xvhkczvjdslpwrorji4thpga 136 2 of of IN work_y6xvhkczvjdslpwrorji4thpga 136 3 soluble soluble JJ work_y6xvhkczvjdslpwrorji4thpga 136 4 wild wild JJ work_y6xvhkczvjdslpwrorji4thpga 136 5 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 136 6 type type NN work_y6xvhkczvjdslpwrorji4thpga 136 7 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 136 8 / / SYM work_y6xvhkczvjdslpwrorji4thpga 136 9 b2 b2 NNP work_y6xvhkczvjdslpwrorji4thpga 136 10 m m NNP work_y6xvhkczvjdslpwrorji4thpga 136 11 heterodimers heterodimer VBZ work_y6xvhkczvjdslpwrorji4thpga 136 12 to to IN work_y6xvhkczvjdslpwrorji4thpga 136 13 cultured cultured JJ work_y6xvhkczvjdslpwrorji4thpga 136 14 cells cell NNS work_y6xvhkczvjdslpwrorji4thpga 136 15 also also RB work_y6xvhkczvjdslpwrorji4thpga 136 16 decreased decrease VBD work_y6xvhkczvjdslpwrorji4thpga 136 17 the the DT work_y6xvhkczvjdslpwrorji4thpga 136 18 apparent apparent JJ work_y6xvhkczvjdslpwrorji4thpga 136 19 affinity affinity NN work_y6xvhkczvjdslpwrorji4thpga 136 20 of of IN work_y6xvhkczvjdslpwrorji4thpga 136 21 the the DT work_y6xvhkczvjdslpwrorji4thpga 136 22 TfR TfR NNP work_y6xvhkczvjdslpwrorji4thpga 136 23 for for IN work_y6xvhkczvjdslpwrorji4thpga 136 24 its -PRON- PRP$ work_y6xvhkczvjdslpwrorji4thpga 136 25 ligand ligand NN work_y6xvhkczvjdslpwrorji4thpga 136 26 under under IN work_y6xvhkczvjdslpwrorji4thpga 136 27 steady steady JJ work_y6xvhkczvjdslpwrorji4thpga 136 28 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 136 29 state state NN work_y6xvhkczvjdslpwrorji4thpga 136 30 conditions condition NNS work_y6xvhkczvjdslpwrorji4thpga 136 31 , , , work_y6xvhkczvjdslpwrorji4thpga 136 32 both both CC work_y6xvhkczvjdslpwrorji4thpga 136 33 in in IN work_y6xvhkczvjdslpwrorji4thpga 136 34 293 293 CD work_y6xvhkczvjdslpwrorji4thpga 136 35 cells cell NNS work_y6xvhkczvjdslpwrorji4thpga 136 36 and and CC work_y6xvhkczvjdslpwrorji4thpga 136 37 in in IN work_y6xvhkczvjdslpwrorji4thpga 136 38 HeLa HeLa NNP work_y6xvhkczvjdslpwrorji4thpga 136 39 cells cell NNS work_y6xvhkczvjdslpwrorji4thpga 136 40 . . . work_y6xvhkczvjdslpwrorji4thpga 137 1 Furthermore furthermore RB work_y6xvhkczvjdslpwrorji4thpga 137 2 , , , work_y6xvhkczvjdslpwrorji4thpga 137 3 at at IN work_y6xvhkczvjdslpwrorji4thpga 137 4 47C 47c CD work_y6xvhkczvjdslpwrorji4thpga 137 5 , , , work_y6xvhkczvjdslpwrorji4thpga 137 6 the the DT work_y6xvhkczvjdslpwrorji4thpga 137 7 added add VBN work_y6xvhkczvjdslpwrorji4thpga 137 8 soluble soluble JJ work_y6xvhkczvjdslpwrorji4thpga 137 9 complex complex NN work_y6xvhkczvjdslpwrorji4thpga 137 10 of of IN work_y6xvhkczvjdslpwrorji4thpga 137 11 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 137 12 / / SYM work_y6xvhkczvjdslpwrorji4thpga 137 13 b2 b2 NNP work_y6xvhkczvjdslpwrorji4thpga 137 14 m m NNP work_y6xvhkczvjdslpwrorji4thpga 137 15 inhibited inhibited JJ work_y6xvhkczvjdslpwrorji4thpga 137 16 binding binding NN work_y6xvhkczvjdslpwrorji4thpga 137 17 of of IN work_y6xvhkczvjdslpwrorji4thpga 137 18 transfer- transfer- JJ work_y6xvhkczvjdslpwrorji4thpga 137 19 rin rin NN work_y6xvhkczvjdslpwrorji4thpga 137 20 to to IN work_y6xvhkczvjdslpwrorji4thpga 137 21 HeLa HeLa NNP work_y6xvhkczvjdslpwrorji4thpga 137 22 cell cell NN work_y6xvhkczvjdslpwrorji4thpga 137 23 TfR TfR NNP work_y6xvhkczvjdslpwrorji4thpga 137 24 in in IN work_y6xvhkczvjdslpwrorji4thpga 137 25 a a DT work_y6xvhkczvjdslpwrorji4thpga 137 26 concentration concentration NN work_y6xvhkczvjdslpwrorji4thpga 137 27 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 137 28 dependent dependent JJ work_y6xvhkczvjdslpwrorji4thpga 137 29 manner manner NN work_y6xvhkczvjdslpwrorji4thpga 137 30 . . . work_y6xvhkczvjdslpwrorji4thpga 138 1 Scatchard scatchard NN work_y6xvhkczvjdslpwrorji4thpga 138 2 plots plot NNS work_y6xvhkczvjdslpwrorji4thpga 138 3 of of IN work_y6xvhkczvjdslpwrorji4thpga 138 4 these these DT work_y6xvhkczvjdslpwrorji4thpga 138 5 data datum NNS work_y6xvhkczvjdslpwrorji4thpga 138 6 indicate indicate VBP work_y6xvhkczvjdslpwrorji4thpga 138 7 that that IN work_y6xvhkczvjdslpwrorji4thpga 138 8 the the DT work_y6xvhkczvjdslpwrorji4thpga 138 9 added added JJ work_y6xvhkczvjdslpwrorji4thpga 138 10 heterodimer heterodimer NN work_y6xvhkczvjdslpwrorji4thpga 138 11 substantially substantially RB work_y6xvhkczvjdslpwrorji4thpga 138 12 reduced reduce VBD work_y6xvhkczvjdslpwrorji4thpga 138 13 the the DT work_y6xvhkczvjdslpwrorji4thpga 138 14 affinity affinity NN work_y6xvhkczvjdslpwrorji4thpga 138 15 of of IN work_y6xvhkczvjdslpwrorji4thpga 138 16 TfR TfR NNP work_y6xvhkczvjdslpwrorji4thpga 138 17 for for IN work_y6xvhkczvjdslpwrorji4thpga 138 18 transferrin transferrin NNP work_y6xvhkczvjdslpwrorji4thpga 138 19 . . . work_y6xvhkczvjdslpwrorji4thpga 139 1 These these DT work_y6xvhkczvjdslpwrorji4thpga 139 2 results result NNS work_y6xvhkczvjdslpwrorji4thpga 139 3 establish establish VBP work_y6xvhkczvjdslpwrorji4thpga 139 4 a a DT work_y6xvhkczvjdslpwrorji4thpga 139 5 molecular molecular JJ work_y6xvhkczvjdslpwrorji4thpga 139 6 link link NN work_y6xvhkczvjdslpwrorji4thpga 139 7 be- be- XX work_y6xvhkczvjdslpwrorji4thpga 139 8 tween tween NN work_y6xvhkczvjdslpwrorji4thpga 139 9 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 139 10 and and CC work_y6xvhkczvjdslpwrorji4thpga 139 11 a a DT work_y6xvhkczvjdslpwrorji4thpga 139 12 key key JJ work_y6xvhkczvjdslpwrorji4thpga 139 13 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 139 14 involved involve VBN work_y6xvhkczvjdslpwrorji4thpga 139 15 in in IN work_y6xvhkczvjdslpwrorji4thpga 139 16 iron iron NN work_y6xvhkczvjdslpwrorji4thpga 139 17 transport transport NN work_y6xvhkczvjdslpwrorji4thpga 139 18 , , , work_y6xvhkczvjdslpwrorji4thpga 139 19 the the DT work_y6xvhkczvjdslpwrorji4thpga 139 20 TfR TfR NNP work_y6xvhkczvjdslpwrorji4thpga 139 21 , , , work_y6xvhkczvjdslpwrorji4thpga 139 22 and and CC work_y6xvhkczvjdslpwrorji4thpga 139 23 raise raise VB work_y6xvhkczvjdslpwrorji4thpga 139 24 the the DT work_y6xvhkczvjdslpwrorji4thpga 139 25 possibility possibility NN work_y6xvhkczvjdslpwrorji4thpga 139 26 that that IN work_y6xvhkczvjdslpwrorji4thpga 139 27 alterations alteration NNS work_y6xvhkczvjdslpwrorji4thpga 139 28 in in IN work_y6xvhkczvjdslpwrorji4thpga 139 29 this this DT work_y6xvhkczvjdslpwrorji4thpga 139 30 regulatory regulatory JJ work_y6xvhkczvjdslpwrorji4thpga 139 31 mechanism mechanism NN work_y6xvhkczvjdslpwrorji4thpga 139 32 may may MD work_y6xvhkczvjdslpwrorji4thpga 139 33 play play VB work_y6xvhkczvjdslpwrorji4thpga 139 34 a a DT work_y6xvhkczvjdslpwrorji4thpga 139 35 role role NN work_y6xvhkczvjdslpwrorji4thpga 139 36 in in IN work_y6xvhkczvjdslpwrorji4thpga 139 37 the the DT work_y6xvhkczvjdslpwrorji4thpga 139 38 pathogenesis pathogenesis NN work_y6xvhkczvjdslpwrorji4thpga 139 39 of of IN work_y6xvhkczvjdslpwrorji4thpga 139 40 hereditary hereditary JJ work_y6xvhkczvjdslpwrorji4thpga 139 41 hemochromatosis hemochromatosis NN work_y6xvhkczvjdslpwrorji4thpga 139 42 . . . work_y6xvhkczvjdslpwrorji4thpga 140 1 COMMENTS comment NNS work_y6xvhkczvjdslpwrorji4thpga 140 2 In in IN work_y6xvhkczvjdslpwrorji4thpga 140 3 recent recent JJ work_y6xvhkczvjdslpwrorji4thpga 140 4 years year NNS work_y6xvhkczvjdslpwrorji4thpga 140 5 , , , work_y6xvhkczvjdslpwrorji4thpga 140 6 many many JJ work_y6xvhkczvjdslpwrorji4thpga 140 7 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 140 8 genes gene NNS work_y6xvhkczvjdslpwrorji4thpga 140 9 have have VBP work_y6xvhkczvjdslpwrorji4thpga 140 10 been be VBN work_y6xvhkczvjdslpwrorji4thpga 140 11 successfully successfully RB work_y6xvhkczvjdslpwrorji4thpga 140 12 cloned clone VBN work_y6xvhkczvjdslpwrorji4thpga 140 13 by by IN work_y6xvhkczvjdslpwrorji4thpga 140 14 establishing establish VBG work_y6xvhkczvjdslpwrorji4thpga 140 15 a a DT work_y6xvhkczvjdslpwrorji4thpga 140 16 linkage linkage NN work_y6xvhkczvjdslpwrorji4thpga 140 17 between between IN work_y6xvhkczvjdslpwrorji4thpga 140 18 the the DT work_y6xvhkczvjdslpwrorji4thpga 140 19 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 140 20 and and CC work_y6xvhkczvjdslpwrorji4thpga 140 21 markers marker NNS work_y6xvhkczvjdslpwrorji4thpga 140 22 from from IN work_y6xvhkczvjdslpwrorji4thpga 140 23 known know VBN work_y6xvhkczvjdslpwrorji4thpga 140 24 locations location NNS work_y6xvhkczvjdslpwrorji4thpga 140 25 in in IN work_y6xvhkczvjdslpwrorji4thpga 140 26 the the DT work_y6xvhkczvjdslpwrorji4thpga 140 27 genome genome NN work_y6xvhkczvjdslpwrorji4thpga 140 28 . . . work_y6xvhkczvjdslpwrorji4thpga 141 1 One one CD work_y6xvhkczvjdslpwrorji4thpga 141 2 of of IN work_y6xvhkczvjdslpwrorji4thpga 141 3 the the DT work_y6xvhkczvjdslpwrorji4thpga 141 4 virtues virtue NNS work_y6xvhkczvjdslpwrorji4thpga 141 5 of of IN work_y6xvhkczvjdslpwrorji4thpga 141 6 a a DT work_y6xvhkczvjdslpwrorji4thpga 141 7 positional positional JJ work_y6xvhkczvjdslpwrorji4thpga 141 8 cloning clone VBG work_y6xvhkczvjdslpwrorji4thpga 141 9 approach approach NN work_y6xvhkczvjdslpwrorji4thpga 141 10 to to TO work_y6xvhkczvjdslpwrorji4thpga 141 11 identify identify VB work_y6xvhkczvjdslpwrorji4thpga 141 12 a a DT work_y6xvhkczvjdslpwrorji4thpga 141 13 disease- disease- JJ work_y6xvhkczvjdslpwrorji4thpga 141 14 related related JJ work_y6xvhkczvjdslpwrorji4thpga 141 15 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 141 16 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 141 17 that that DT work_y6xvhkczvjdslpwrorji4thpga 141 18 information information NN work_y6xvhkczvjdslpwrorji4thpga 141 19 about about IN work_y6xvhkczvjdslpwrorji4thpga 141 20 the the DT work_y6xvhkczvjdslpwrorji4thpga 141 21 function function NN work_y6xvhkczvjdslpwrorji4thpga 141 22 of of IN work_y6xvhkczvjdslpwrorji4thpga 141 23 the the DT work_y6xvhkczvjdslpwrorji4thpga 141 24 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 141 25 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 141 26 not not RB work_y6xvhkczvjdslpwrorji4thpga 141 27 required require VBN work_y6xvhkczvjdslpwrorji4thpga 141 28 for for IN work_y6xvhkczvjdslpwrorji4thpga 141 29 success success NN work_y6xvhkczvjdslpwrorji4thpga 141 30 . . . work_y6xvhkczvjdslpwrorji4thpga 142 1 As as RB work_y6xvhkczvjdslpwrorji4thpga 142 2 long long RB work_y6xvhkczvjdslpwrorji4thpga 142 3 as as IN work_y6xvhkczvjdslpwrorji4thpga 142 4 patients patient NNS work_y6xvhkczvjdslpwrorji4thpga 142 5 with with IN work_y6xvhkczvjdslpwrorji4thpga 142 6 the the DT work_y6xvhkczvjdslpwrorji4thpga 142 7 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 142 8 can can MD work_y6xvhkczvjdslpwrorji4thpga 142 9 be be VB work_y6xvhkczvjdslpwrorji4thpga 142 10 unequivocally unequivocally RB work_y6xvhkczvjdslpwrorji4thpga 142 11 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 142 12 , , , work_y6xvhkczvjdslpwrorji4thpga 142 13 the the DT work_y6xvhkczvjdslpwrorji4thpga 142 14 discovery discovery NN work_y6xvhkczvjdslpwrorji4thpga 142 15 of of IN work_y6xvhkczvjdslpwrorji4thpga 142 16 mutations mutation NNS work_y6xvhkczvjdslpwrorji4thpga 142 17 within within IN work_y6xvhkczvjdslpwrorji4thpga 142 18 a a DT work_y6xvhkczvjdslpwrorji4thpga 142 19 candidate candidate NN work_y6xvhkczvjdslpwrorji4thpga 142 20 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 142 21 in in IN work_y6xvhkczvjdslpwrorji4thpga 142 22 affected affect VBN work_y6xvhkczvjdslpwrorji4thpga 142 23 individuals individual NNS work_y6xvhkczvjdslpwrorji4thpga 142 24 but but CC work_y6xvhkczvjdslpwrorji4thpga 142 25 not not RB work_y6xvhkczvjdslpwrorji4thpga 142 26 in in IN work_y6xvhkczvjdslpwrorji4thpga 142 27 healthy healthy JJ work_y6xvhkczvjdslpwrorji4thpga 142 28 individuals individual NNS work_y6xvhkczvjdslpwrorji4thpga 142 29 should should MD work_y6xvhkczvjdslpwrorji4thpga 142 30 be be VB work_y6xvhkczvjdslpwrorji4thpga 142 31 sufficient sufficient JJ work_y6xvhkczvjdslpwrorji4thpga 142 32 to to TO work_y6xvhkczvjdslpwrorji4thpga 142 33 prove prove VB work_y6xvhkczvjdslpwrorji4thpga 142 34 that that IN work_y6xvhkczvjdslpwrorji4thpga 142 35 the the DT work_y6xvhkczvjdslpwrorji4thpga 142 36 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 142 37 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 142 38 correct correct JJ work_y6xvhkczvjdslpwrorji4thpga 142 39 . . . work_y6xvhkczvjdslpwrorji4thpga 143 1 Positional positional JJ work_y6xvhkczvjdslpwrorji4thpga 143 2 cloning cloning NN work_y6xvhkczvjdslpwrorji4thpga 143 3 has have VBZ work_y6xvhkczvjdslpwrorji4thpga 143 4 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 143 5 many many JJ work_y6xvhkczvjdslpwrorji4thpga 143 6 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 143 7 genes gene NNS work_y6xvhkczvjdslpwrorji4thpga 143 8 ; ; : work_y6xvhkczvjdslpwrorji4thpga 143 9 however however RB work_y6xvhkczvjdslpwrorji4thpga 143 10 , , , work_y6xvhkczvjdslpwrorji4thpga 143 11 there there EX work_y6xvhkczvjdslpwrorji4thpga 143 12 are be VBP work_y6xvhkczvjdslpwrorji4thpga 143 13 several several JJ work_y6xvhkczvjdslpwrorji4thpga 143 14 situations situation NNS work_y6xvhkczvjdslpwrorji4thpga 143 15 in in IN work_y6xvhkczvjdslpwrorji4thpga 143 16 which which WDT work_y6xvhkczvjdslpwrorji4thpga 143 17 a a DT work_y6xvhkczvjdslpwrorji4thpga 143 18 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 143 19 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 143 20 bore bear VBD work_y6xvhkczvjdslpwrorji4thpga 143 21 no no DT work_y6xvhkczvjdslpwrorji4thpga 143 22 resemblance resemblance NN work_y6xvhkczvjdslpwrorji4thpga 143 23 to to IN work_y6xvhkczvjdslpwrorji4thpga 143 24 genes gene NNS work_y6xvhkczvjdslpwrorji4thpga 143 25 of of IN work_y6xvhkczvjdslpwrorji4thpga 143 26 known know VBN work_y6xvhkczvjdslpwrorji4thpga 143 27 function function NN work_y6xvhkczvjdslpwrorji4thpga 143 28 and and CC work_y6xvhkczvjdslpwrorji4thpga 143 29 , , , work_y6xvhkczvjdslpwrorji4thpga 143 30 thus thus RB work_y6xvhkczvjdslpwrorji4thpga 143 31 , , , work_y6xvhkczvjdslpwrorji4thpga 143 32 provided provide VBN work_y6xvhkczvjdslpwrorji4thpga 143 33 little little JJ work_y6xvhkczvjdslpwrorji4thpga 143 34 insight insight NN work_y6xvhkczvjdslpwrorji4thpga 143 35 into into IN work_y6xvhkczvjdslpwrorji4thpga 143 36 pathogenesis pathogenesis NN work_y6xvhkczvjdslpwrorji4thpga 143 37 . . . work_y6xvhkczvjdslpwrorji4thpga 144 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 144 2 other other JJ work_y6xvhkczvjdslpwrorji4thpga 144 3 instances instance NNS work_y6xvhkczvjdslpwrorji4thpga 144 4 , , , work_y6xvhkczvjdslpwrorji4thpga 144 5 a a DT work_y6xvhkczvjdslpwrorji4thpga 144 6 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 144 7 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 144 8 resembled resemble VBD work_y6xvhkczvjdslpwrorji4thpga 144 9 known know VBN work_y6xvhkczvjdslpwrorji4thpga 144 10 genes gene NNS work_y6xvhkczvjdslpwrorji4thpga 144 11 but but CC work_y6xvhkczvjdslpwrorji4thpga 144 12 the the DT work_y6xvhkczvjdslpwrorji4thpga 144 13 relationship relationship NN work_y6xvhkczvjdslpwrorji4thpga 144 14 between between IN work_y6xvhkczvjdslpwrorji4thpga 144 15 the the DT work_y6xvhkczvjdslpwrorji4thpga 144 16 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 144 17 and and CC work_y6xvhkczvjdslpwrorji4thpga 144 18 the the DT work_y6xvhkczvjdslpwrorji4thpga 144 19 disease disease NN work_y6xvhkczvjdslpwrorji4thpga 144 20 process process NN work_y6xvhkczvjdslpwrorji4thpga 144 21 was be VBD work_y6xvhkczvjdslpwrorji4thpga 144 22 initially initially RB work_y6xvhkczvjdslpwrorji4thpga 144 23 obscure obscure JJ work_y6xvhkczvjdslpwrorji4thpga 144 24 . . . work_y6xvhkczvjdslpwrorji4thpga 145 1 Such such JJ work_y6xvhkczvjdslpwrorji4thpga 145 2 was be VBD work_y6xvhkczvjdslpwrorji4thpga 145 3 the the DT work_y6xvhkczvjdslpwrorji4thpga 145 4 case case NN work_y6xvhkczvjdslpwrorji4thpga 145 5 for for IN work_y6xvhkczvjdslpwrorji4thpga 145 6 hereditary hereditary JJ work_y6xvhkczvjdslpwrorji4thpga 145 7 hemochro- hemochro- NNP work_y6xvhkczvjdslpwrorji4thpga 145 8 matosis matosis NN work_y6xvhkczvjdslpwrorji4thpga 145 9 , , , work_y6xvhkczvjdslpwrorji4thpga 145 10 whose whose WP$ work_y6xvhkczvjdslpwrorji4thpga 145 11 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 145 12 named name VBN work_y6xvhkczvjdslpwrorji4thpga 145 13 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 145 14 was be VBD work_y6xvhkczvjdslpwrorji4thpga 145 15 cloned clone VBN work_y6xvhkczvjdslpwrorji4thpga 145 16 in in IN work_y6xvhkczvjdslpwrorji4thpga 145 17 1996.1 1996.1 CD work_y6xvhkczvjdslpwrorji4thpga 145 18 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 145 19 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 145 20 similar similar JJ work_y6xvhkczvjdslpwrorji4thpga 145 21 in in IN work_y6xvhkczvjdslpwrorji4thpga 145 22 sequence sequence NN work_y6xvhkczvjdslpwrorji4thpga 145 23 to to IN work_y6xvhkczvjdslpwrorji4thpga 145 24 major major JJ work_y6xvhkczvjdslpwrorji4thpga 145 25 histocompatibility histocompatibility NN work_y6xvhkczvjdslpwrorji4thpga 145 26 complex complex JJ work_y6xvhkczvjdslpwrorji4thpga 145 27 class class NN work_y6xvhkczvjdslpwrorji4thpga 145 28 I -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 145 29 genes gene NNS work_y6xvhkczvjdslpwrorji4thpga 145 30 , , , work_y6xvhkczvjdslpwrorji4thpga 145 31 a a DT work_y6xvhkczvjdslpwrorji4thpga 145 32 family family NN work_y6xvhkczvjdslpwrorji4thpga 145 33 of of IN work_y6xvhkczvjdslpwrorji4thpga 145 34 polymorphic polymorphic JJ work_y6xvhkczvjdslpwrorji4thpga 145 35 integral integral JJ work_y6xvhkczvjdslpwrorji4thpga 145 36 membrane membrane NN work_y6xvhkczvjdslpwrorji4thpga 145 37 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 145 38 that that WDT work_y6xvhkczvjdslpwrorji4thpga 145 39 associate associate VBP work_y6xvhkczvjdslpwrorji4thpga 145 40 noncovalently noncovalently RB work_y6xvhkczvjdslpwrorji4thpga 145 41 with with IN work_y6xvhkczvjdslpwrorji4thpga 145 42 a a DT work_y6xvhkczvjdslpwrorji4thpga 145 43 12-kd 12-kd CD work_y6xvhkczvjdslpwrorji4thpga 145 44 protein protein NN work_y6xvhkczvjdslpwrorji4thpga 145 45 b2 b2 NN work_y6xvhkczvjdslpwrorji4thpga 145 46 microglobulin microglobulin NNP work_y6xvhkczvjdslpwrorji4thpga 145 47 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 145 48 b2 b2 NNP work_y6xvhkczvjdslpwrorji4thpga 145 49 m m NNP work_y6xvhkczvjdslpwrorji4thpga 145 50 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 145 51 . . . work_y6xvhkczvjdslpwrorji4thpga 146 1 Within within IN work_y6xvhkczvjdslpwrorji4thpga 146 2 the the DT work_y6xvhkczvjdslpwrorji4thpga 146 3 endoplasmic endoplasmic JJ work_y6xvhkczvjdslpwrorji4thpga 146 4 reticulum reticulum NN work_y6xvhkczvjdslpwrorji4thpga 146 5 , , , work_y6xvhkczvjdslpwrorji4thpga 146 6 class class NN work_y6xvhkczvjdslpwrorji4thpga 146 7 I -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 146 8 molecules molecule VBZ work_y6xvhkczvjdslpwrorji4thpga 146 9 capture capture VBP work_y6xvhkczvjdslpwrorji4thpga 146 10 and and CC work_y6xvhkczvjdslpwrorji4thpga 146 11 bind bind NN work_y6xvhkczvjdslpwrorji4thpga 146 12 peptides peptide NNS work_y6xvhkczvjdslpwrorji4thpga 146 13 derived derive VBN work_y6xvhkczvjdslpwrorji4thpga 146 14 from from IN work_y6xvhkczvjdslpwrorji4thpga 146 15 proteolytic proteolytic JJ work_y6xvhkczvjdslpwrorji4thpga 146 16 digestion digestion NN work_y6xvhkczvjdslpwrorji4thpga 146 17 of of IN work_y6xvhkczvjdslpwrorji4thpga 146 18 intracellular intracellular JJ work_y6xvhkczvjdslpwrorji4thpga 146 19 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 146 20 . . . work_y6xvhkczvjdslpwrorji4thpga 147 1 Once once RB work_y6xvhkczvjdslpwrorji4thpga 147 2 peptide peptide NN work_y6xvhkczvjdslpwrorji4thpga 147 3 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 147 4 bound bind VBN work_y6xvhkczvjdslpwrorji4thpga 147 5 to to IN work_y6xvhkczvjdslpwrorji4thpga 147 6 a a DT work_y6xvhkczvjdslpwrorji4thpga 147 7 class class NN work_y6xvhkczvjdslpwrorji4thpga 147 8 I -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 147 9 molecule molecule VBP work_y6xvhkczvjdslpwrorji4thpga 147 10 , , , work_y6xvhkczvjdslpwrorji4thpga 147 11 the the DT work_y6xvhkczvjdslpwrorji4thpga 147 12 complex complex NN work_y6xvhkczvjdslpwrorji4thpga 147 13 exits exit VBZ work_y6xvhkczvjdslpwrorji4thpga 147 14 the the DT work_y6xvhkczvjdslpwrorji4thpga 147 15 endoplasmic endoplasmic JJ work_y6xvhkczvjdslpwrorji4thpga 147 16 reticulum reticulum NN work_y6xvhkczvjdslpwrorji4thpga 147 17 and and CC work_y6xvhkczvjdslpwrorji4thpga 147 18 moves move NNS work_y6xvhkczvjdslpwrorji4thpga 147 19 to to IN work_y6xvhkczvjdslpwrorji4thpga 147 20 the the DT work_y6xvhkczvjdslpwrorji4thpga 147 21 cell cell NN work_y6xvhkczvjdslpwrorji4thpga 147 22 surface surface NN work_y6xvhkczvjdslpwrorji4thpga 147 23 where where WRB work_y6xvhkczvjdslpwrorji4thpga 147 24 peptides peptide NNS work_y6xvhkczvjdslpwrorji4thpga 147 25 from from IN work_y6xvhkczvjdslpwrorji4thpga 147 26 viral viral JJ work_y6xvhkczvjdslpwrorji4thpga 147 27 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 147 28 that that WDT work_y6xvhkczvjdslpwrorji4thpga 147 29 are be VBP work_y6xvhkczvjdslpwrorji4thpga 147 30 expressed express VBN work_y6xvhkczvjdslpwrorji4thpga 147 31 in in IN work_y6xvhkczvjdslpwrorji4thpga 147 32 an an DT work_y6xvhkczvjdslpwrorji4thpga 147 33 infected infected JJ work_y6xvhkczvjdslpwrorji4thpga 147 34 cell cell NN work_y6xvhkczvjdslpwrorji4thpga 147 35 can can MD work_y6xvhkczvjdslpwrorji4thpga 147 36 be be VB work_y6xvhkczvjdslpwrorji4thpga 147 37 recognized recognize VBN work_y6xvhkczvjdslpwrorji4thpga 147 38 as as IN work_y6xvhkczvjdslpwrorji4thpga 147 39 foreign foreign JJ work_y6xvhkczvjdslpwrorji4thpga 147 40 and and CC work_y6xvhkczvjdslpwrorji4thpga 147 41 can can MD work_y6xvhkczvjdslpwrorji4thpga 147 42 target target VB work_y6xvhkczvjdslpwrorji4thpga 147 43 the the DT work_y6xvhkczvjdslpwrorji4thpga 147 44 cell cell NN work_y6xvhkczvjdslpwrorji4thpga 147 45 for for IN work_y6xvhkczvjdslpwrorji4thpga 147 46 destruction destruction NN work_y6xvhkczvjdslpwrorji4thpga 147 47 by by IN work_y6xvhkczvjdslpwrorji4thpga 147 48 T t NN work_y6xvhkczvjdslpwrorji4thpga 147 49 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 147 50 lymphocytes lymphocyte NNS work_y6xvhkczvjdslpwrorji4thpga 147 51 . . . work_y6xvhkczvjdslpwrorji4thpga 148 1 There there EX work_y6xvhkczvjdslpwrorji4thpga 148 2 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 148 3 another another DT work_y6xvhkczvjdslpwrorji4thpga 148 4 group group NN work_y6xvhkczvjdslpwrorji4thpga 148 5 of of IN work_y6xvhkczvjdslpwrorji4thpga 148 6 major major JJ work_y6xvhkczvjdslpwrorji4thpga 148 7 histocompatibility histocompatibility NN work_y6xvhkczvjdslpwrorji4thpga 148 8 complex complex JJ work_y6xvhkczvjdslpwrorji4thpga 148 9 class class NN work_y6xvhkczvjdslpwrorji4thpga 148 10 I -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 148 11 proteins protein VBZ work_y6xvhkczvjdslpwrorji4thpga 148 12 that that WDT work_y6xvhkczvjdslpwrorji4thpga 148 13 are be VBP work_y6xvhkczvjdslpwrorji4thpga 148 14 atypical atypical JJ work_y6xvhkczvjdslpwrorji4thpga 148 15 in in IN work_y6xvhkczvjdslpwrorji4thpga 148 16 that that IN work_y6xvhkczvjdslpwrorji4thpga 148 17 they -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 148 18 have have VBP work_y6xvhkczvjdslpwrorji4thpga 148 19 maintained maintain VBN work_y6xvhkczvjdslpwrorji4thpga 148 20 the the DT work_y6xvhkczvjdslpwrorji4thpga 148 21 basic basic JJ work_y6xvhkczvjdslpwrorji4thpga 148 22 structure structure NN work_y6xvhkczvjdslpwrorji4thpga 148 23 of of IN work_y6xvhkczvjdslpwrorji4thpga 148 24 class class NN work_y6xvhkczvjdslpwrorji4thpga 148 25 I -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 148 26 molecules molecule VBZ work_y6xvhkczvjdslpwrorji4thpga 148 27 , , , work_y6xvhkczvjdslpwrorji4thpga 148 28 but but CC work_y6xvhkczvjdslpwrorji4thpga 148 29 have have VBP work_y6xvhkczvjdslpwrorji4thpga 148 30 other other JJ work_y6xvhkczvjdslpwrorji4thpga 148 31 biological biological JJ work_y6xvhkczvjdslpwrorji4thpga 148 32 roles role NNS work_y6xvhkczvjdslpwrorji4thpga 148 33 , , , work_y6xvhkczvjdslpwrorji4thpga 148 34 as as IN work_y6xvhkczvjdslpwrorji4thpga 148 35 in in IN work_y6xvhkczvjdslpwrorji4thpga 148 36 the the DT work_y6xvhkczvjdslpwrorji4thpga 148 37 case case NN work_y6xvhkczvjdslpwrorji4thpga 148 38 of of IN work_y6xvhkczvjdslpwrorji4thpga 148 39 CD1 CD1 NNP work_y6xvhkczvjdslpwrorji4thpga 148 40 and and CC work_y6xvhkczvjdslpwrorji4thpga 148 41 the the DT work_y6xvhkczvjdslpwrorji4thpga 148 42 neonatal neonatal NN work_y6xvhkczvjdslpwrorji4thpga 148 43 Fc Fc NNP work_y6xvhkczvjdslpwrorji4thpga 148 44 receptor.2 receptor.2 NNP work_y6xvhkczvjdslpwrorji4thpga 148 45 Although although IN work_y6xvhkczvjdslpwrorji4thpga 148 46 the the DT work_y6xvhkczvjdslpwrorji4thpga 148 47 mechanism mechanism NN work_y6xvhkczvjdslpwrorji4thpga 148 48 by by IN work_y6xvhkczvjdslpwrorji4thpga 148 49 which which WDT work_y6xvhkczvjdslpwrorji4thpga 148 50 an an DT work_y6xvhkczvjdslpwrorji4thpga 148 51 abnormality abnormality NN work_y6xvhkczvjdslpwrorji4thpga 148 52 in in IN work_y6xvhkczvjdslpwrorji4thpga 148 53 a a DT work_y6xvhkczvjdslpwrorji4thpga 148 54 class class NN work_y6xvhkczvjdslpwrorji4thpga 148 55 I -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 148 56 – – : work_y6xvhkczvjdslpwrorji4thpga 148 57 like like IN work_y6xvhkczvjdslpwrorji4thpga 148 58 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 148 59 would would MD work_y6xvhkczvjdslpwrorji4thpga 148 60 lead lead VB work_y6xvhkczvjdslpwrorji4thpga 148 61 to to IN work_y6xvhkczvjdslpwrorji4thpga 148 62 iron iron NN work_y6xvhkczvjdslpwrorji4thpga 148 63 overload overload NN work_y6xvhkczvjdslpwrorji4thpga 148 64 was be VBD work_y6xvhkczvjdslpwrorji4thpga 148 65 initially initially RB work_y6xvhkczvjdslpwrorji4thpga 148 66 quite quite RB work_y6xvhkczvjdslpwrorji4thpga 148 67 obscure obscure JJ work_y6xvhkczvjdslpwrorji4thpga 148 68 , , , work_y6xvhkczvjdslpwrorji4thpga 148 69 the the DT work_y6xvhkczvjdslpwrorji4thpga 148 70 observation observation NN work_y6xvhkczvjdslpwrorji4thpga 148 71 fit fit VBD work_y6xvhkczvjdslpwrorji4thpga 148 72 well well RB work_y6xvhkczvjdslpwrorji4thpga 148 73 with with IN work_y6xvhkczvjdslpwrorji4thpga 148 74 previous previous JJ work_y6xvhkczvjdslpwrorji4thpga 148 75 data datum NNS work_y6xvhkczvjdslpwrorji4thpga 148 76 that that WDT work_y6xvhkczvjdslpwrorji4thpga 148 77 mice mice VBZ work_y6xvhkczvjdslpwrorji4thpga 148 78 homozygous homozygous JJ work_y6xvhkczvjdslpwrorji4thpga 148 79 for for IN work_y6xvhkczvjdslpwrorji4thpga 148 80 a a DT work_y6xvhkczvjdslpwrorji4thpga 148 81 targeted target VBN work_y6xvhkczvjdslpwrorji4thpga 148 82 disruption disruption NN work_y6xvhkczvjdslpwrorji4thpga 148 83 in in IN work_y6xvhkczvjdslpwrorji4thpga 148 84 the the DT work_y6xvhkczvjdslpwrorji4thpga 148 85 b2 b2 NN work_y6xvhkczvjdslpwrorji4thpga 148 86 m m NN work_y6xvhkczvjdslpwrorji4thpga 148 87 gene gene NN work_y6xvhkczvjdslpwrorji4thpga 148 88 develop develop VBP work_y6xvhkczvjdslpwrorji4thpga 148 89 iron iron NN work_y6xvhkczvjdslpwrorji4thpga 148 90 overload overload NN work_y6xvhkczvjdslpwrorji4thpga 148 91 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 148 92 presumably presumably RB work_y6xvhkczvjdslpwrorji4thpga 148 93 as as IN work_y6xvhkczvjdslpwrorji4thpga 148 94 a a DT work_y6xvhkczvjdslpwrorji4thpga 148 95 consequence consequence NN work_y6xvhkczvjdslpwrorji4thpga 148 96 of of IN work_y6xvhkczvjdslpwrorji4thpga 148 97 loss loss NN work_y6xvhkczvjdslpwrorji4thpga 148 98 of of IN work_y6xvhkczvjdslpwrorji4thpga 148 99 b2 b2 NN work_y6xvhkczvjdslpwrorji4thpga 148 100 m m NNP work_y6xvhkczvjdslpwrorji4thpga 148 101 and and CC work_y6xvhkczvjdslpwrorji4thpga 148 102 , , , work_y6xvhkczvjdslpwrorji4thpga 148 103 therefore therefore RB work_y6xvhkczvjdslpwrorji4thpga 148 104 , , , work_y6xvhkczvjdslpwrorji4thpga 148 105 loss loss NN work_y6xvhkczvjdslpwrorji4thpga 148 106 of of IN work_y6xvhkczvjdslpwrorji4thpga 148 107 the the DT work_y6xvhkczvjdslpwrorji4thpga 148 108 functional functional JJ work_y6xvhkczvjdslpwrorji4thpga 148 109 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 148 110 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 148 111 b2 b2 NNP work_y6xvhkczvjdslpwrorji4thpga 148 112 m m NNP work_y6xvhkczvjdslpwrorji4thpga 148 113 complex).3 complex).3 NNP work_y6xvhkczvjdslpwrorji4thpga 148 114 Subsequently subsequently RB work_y6xvhkczvjdslpwrorji4thpga 148 115 , , , work_y6xvhkczvjdslpwrorji4thpga 148 116 it -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 148 117 has have VBZ work_y6xvhkczvjdslpwrorji4thpga 148 118 been be VBN work_y6xvhkczvjdslpwrorji4thpga 148 119 shown show VBN work_y6xvhkczvjdslpwrorji4thpga 148 120 that that IN work_y6xvhkczvjdslpwrorji4thpga 148 121 mice mouse NNS work_y6xvhkczvjdslpwrorji4thpga 148 122 homo- homo- NNP work_y6xvhkczvjdslpwrorji4thpga 148 123 zygous zygous NNP work_y6xvhkczvjdslpwrorji4thpga 148 124 for for IN work_y6xvhkczvjdslpwrorji4thpga 148 125 a a DT work_y6xvhkczvjdslpwrorji4thpga 148 126 targeted target VBN work_y6xvhkczvjdslpwrorji4thpga 148 127 disruption disruption NN work_y6xvhkczvjdslpwrorji4thpga 148 128 of of IN work_y6xvhkczvjdslpwrorji4thpga 148 129 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 148 130 also also RB work_y6xvhkczvjdslpwrorji4thpga 148 131 develop develop VBP work_y6xvhkczvjdslpwrorji4thpga 148 132 iron iron NN work_y6xvhkczvjdslpwrorji4thpga 148 133 overload overload NN work_y6xvhkczvjdslpwrorji4thpga 148 134 similar similar JJ work_y6xvhkczvjdslpwrorji4thpga 148 135 to to IN work_y6xvhkczvjdslpwrorji4thpga 148 136 that that DT work_y6xvhkczvjdslpwrorji4thpga 148 137 in in IN work_y6xvhkczvjdslpwrorji4thpga 148 138 hereditary hereditary JJ work_y6xvhkczvjdslpwrorji4thpga 148 139 hemochromatosis hemochromatosis NN work_y6xvhkczvjdslpwrorji4thpga 148 140 . . . work_y6xvhkczvjdslpwrorji4thpga 149 1 Together together RB work_y6xvhkczvjdslpwrorji4thpga 149 2 these these DT work_y6xvhkczvjdslpwrorji4thpga 149 3 findings finding NNS work_y6xvhkczvjdslpwrorji4thpga 149 4 confirm confirm VBP work_y6xvhkczvjdslpwrorji4thpga 149 5 that that IN work_y6xvhkczvjdslpwrorji4thpga 149 6 functional functional JJ work_y6xvhkczvjdslpwrorji4thpga 149 7 absence absence NN work_y6xvhkczvjdslpwrorji4thpga 149 8 of of IN work_y6xvhkczvjdslpwrorji4thpga 149 9 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 149 10 leads lead VBZ work_y6xvhkczvjdslpwrorji4thpga 149 11 to to IN work_y6xvhkczvjdslpwrorji4thpga 149 12 hemochromatosis.4 hemochromatosis.4 UH work_y6xvhkczvjdslpwrorji4thpga 149 13 Because because IN work_y6xvhkczvjdslpwrorji4thpga 149 14 loss loss NN work_y6xvhkczvjdslpwrorji4thpga 149 15 of of IN work_y6xvhkczvjdslpwrorji4thpga 149 16 HFE hfe NN work_y6xvhkczvjdslpwrorji4thpga 149 17 results result NNS work_y6xvhkczvjdslpwrorji4thpga 149 18 in in IN work_y6xvhkczvjdslpwrorji4thpga 149 19 iron iron NN work_y6xvhkczvjdslpwrorji4thpga 149 20 overload overload NN work_y6xvhkczvjdslpwrorji4thpga 149 21 , , , work_y6xvhkczvjdslpwrorji4thpga 149 22 it -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 149 23 is be VBZ work_y6xvhkczvjdslpwrorji4thpga 149 24 reason- reason- NN work_y6xvhkczvjdslpwrorji4thpga 149 25 able able JJ work_y6xvhkczvjdslpwrorji4thpga 149 26 to to TO work_y6xvhkczvjdslpwrorji4thpga 149 27 expect expect VB work_y6xvhkczvjdslpwrorji4thpga 149 28 that that IN work_y6xvhkczvjdslpwrorji4thpga 149 29 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 149 30 interacts interact NNS work_y6xvhkczvjdslpwrorji4thpga 149 31 in in IN work_y6xvhkczvjdslpwrorji4thpga 149 32 some some DT work_y6xvhkczvjdslpwrorji4thpga 149 33 fashion fashion NN work_y6xvhkczvjdslpwrorji4thpga 149 34 with with IN work_y6xvhkczvjdslpwrorji4thpga 149 35 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 149 36 of of IN work_y6xvhkczvjdslpwrorji4thpga 149 37 iron iron NN work_y6xvhkczvjdslpwrorji4thpga 149 38 metabolism metabolism NN work_y6xvhkczvjdslpwrorji4thpga 149 39 . . . work_y6xvhkczvjdslpwrorji4thpga 150 1 To to TO work_y6xvhkczvjdslpwrorji4thpga 150 2 attempt attempt VB work_y6xvhkczvjdslpwrorji4thpga 150 3 to to TO work_y6xvhkczvjdslpwrorji4thpga 150 4 identify identify VB work_y6xvhkczvjdslpwrorji4thpga 150 5 potential potential JJ work_y6xvhkczvjdslpwrorji4thpga 150 6 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 150 7 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 150 8 interacting interact VBG work_y6xvhkczvjdslpwrorji4thpga 150 9 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 150 10 , , , work_y6xvhkczvjdslpwrorji4thpga 150 11 Feder Feder NNP work_y6xvhkczvjdslpwrorji4thpga 150 12 et et NNP work_y6xvhkczvjdslpwrorji4thpga 150 13 al al NNP work_y6xvhkczvjdslpwrorji4thpga 150 14 . . . work_y6xvhkczvjdslpwrorji4thpga 151 1 analyzed analyze VBN work_y6xvhkczvjdslpwrorji4thpga 151 2 immunopre- immunopre- NN work_y6xvhkczvjdslpwrorji4thpga 151 3 cipitates cipitate NNS work_y6xvhkczvjdslpwrorji4thpga 151 4 from from IN work_y6xvhkczvjdslpwrorji4thpga 151 5 cells cell NNS work_y6xvhkczvjdslpwrorji4thpga 151 6 in in IN work_y6xvhkczvjdslpwrorji4thpga 151 7 which which WDT work_y6xvhkczvjdslpwrorji4thpga 151 8 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 151 9 was be VBD work_y6xvhkczvjdslpwrorji4thpga 151 10 overexpressed overexpresse VBN work_y6xvhkczvjdslpwrorji4thpga 151 11 . . . work_y6xvhkczvjdslpwrorji4thpga 152 1 Initially initially RB work_y6xvhkczvjdslpwrorji4thpga 152 2 , , , work_y6xvhkczvjdslpwrorji4thpga 152 3 cell cell NN work_y6xvhkczvjdslpwrorji4thpga 152 4 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 152 5 surface surface NN work_y6xvhkczvjdslpwrorji4thpga 152 6 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 152 7 were be VBD work_y6xvhkczvjdslpwrorji4thpga 152 8 labeled label VBN work_y6xvhkczvjdslpwrorji4thpga 152 9 with with IN work_y6xvhkczvjdslpwrorji4thpga 152 10 N n NN work_y6xvhkczvjdslpwrorji4thpga 152 11 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 152 12 hydroxysuccin- hydroxysuccin- NN work_y6xvhkczvjdslpwrorji4thpga 152 13 amide amide NN work_y6xvhkczvjdslpwrorji4thpga 152 14 , , , work_y6xvhkczvjdslpwrorji4thpga 152 15 and and CC work_y6xvhkczvjdslpwrorji4thpga 152 16 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 152 17 was be VBD work_y6xvhkczvjdslpwrorji4thpga 152 18 immunoprecipitated immunoprecipitate VBN work_y6xvhkczvjdslpwrorji4thpga 152 19 with with IN work_y6xvhkczvjdslpwrorji4thpga 152 20 antibodies antibody NNS work_y6xvhkczvjdslpwrorji4thpga 152 21 to to IN work_y6xvhkczvjdslpwrorji4thpga 152 22 the the DT work_y6xvhkczvjdslpwrorji4thpga 152 23 native native JJ work_y6xvhkczvjdslpwrorji4thpga 152 24 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 152 25 C C NNP work_y6xvhkczvjdslpwrorji4thpga 152 26 - - HYPH work_y6xvhkczvjdslpwrorji4thpga 152 27 terminus terminus NN work_y6xvhkczvjdslpwrorji4thpga 152 28 or or CC work_y6xvhkczvjdslpwrorji4thpga 152 29 to to IN work_y6xvhkczvjdslpwrorji4thpga 152 30 an an DT work_y6xvhkczvjdslpwrorji4thpga 152 31 epitope epitope NN work_y6xvhkczvjdslpwrorji4thpga 152 32 tag tag NN work_y6xvhkczvjdslpwrorji4thpga 152 33 inserted insert VBN work_y6xvhkczvjdslpwrorji4thpga 152 34 in in IN work_y6xvhkczvjdslpwrorji4thpga 152 35 the the DT work_y6xvhkczvjdslpwrorji4thpga 152 36 overexpressed overexpresse VBN work_y6xvhkczvjdslpwrorji4thpga 152 37 HFE hfe NN work_y6xvhkczvjdslpwrorji4thpga 152 38 . . . work_y6xvhkczvjdslpwrorji4thpga 153 1 In in IN work_y6xvhkczvjdslpwrorji4thpga 153 2 these these DT work_y6xvhkczvjdslpwrorji4thpga 153 3 experiments experiment NNS work_y6xvhkczvjdslpwrorji4thpga 153 4 , , , work_y6xvhkczvjdslpwrorji4thpga 153 5 HFE HFE NNP work_y6xvhkczvjdslpwrorji4thpga 153 6 and and CC work_y6xvhkczvjdslpwrorji4thpga 153 7 b2 b2 NNP work_y6xvhkczvjdslpwrorji4thpga 153 8 m m NNP work_y6xvhkczvjdslpwrorji4thpga 153 9 were be VBD work_y6xvhkczvjdslpwrorji4thpga 153 10 coimmunoprecipitated coimmunoprecipitate VBN work_y6xvhkczvjdslpwrorji4thpga 153 11 as as IN work_y6xvhkczvjdslpwrorji4thpga 153 12 expected expect VBN work_y6xvhkczvjdslpwrorji4thpga 153 13 , , , work_y6xvhkczvjdslpwrorji4thpga 153 14 but but CC work_y6xvhkczvjdslpwrorji4thpga 153 15 in in IN work_y6xvhkczvjdslpwrorji4thpga 153 16 addition addition NN work_y6xvhkczvjdslpwrorji4thpga 153 17 , , , work_y6xvhkczvjdslpwrorji4thpga 153 18 other other JJ work_y6xvhkczvjdslpwrorji4thpga 153 19 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 153 20 were be VBD work_y6xvhkczvjdslpwrorji4thpga 153 21 identified identify VBN work_y6xvhkczvjdslpwrorji4thpga 153 22 at at IN work_y6xvhkczvjdslpwrorji4thpga 153 23 approximately approximately RB work_y6xvhkczvjdslpwrorji4thpga 153 24 100 100 CD work_y6xvhkczvjdslpwrorji4thpga 153 25 and and CC work_y6xvhkczvjdslpwrorji4thpga 153 26 200 200 CD work_y6xvhkczvjdslpwrorji4thpga 153 27 kd kd NNS work_y6xvhkczvjdslpwrorji4thpga 153 28 . . . work_y6xvhkczvjdslpwrorji4thpga 154 1 When when WRB work_y6xvhkczvjdslpwrorji4thpga 154 2 known know VBN work_y6xvhkczvjdslpwrorji4thpga 154 3 proteins protein NNS work_y6xvhkczvjdslpwrorji4thpga 154 4 of of IN work_y6xvhkczvjdslpwrorji4thpga 154 5 iron iron NN work_y6xvhkczvjdslpwrorji4thpga 154 6 metabolism metabolism NN work_y6xvhkczvjdslpwrorji4thpga 154 7 were be VBD work_y6xvhkczvjdslpwrorji4thpga 154 8 considered consider VBN work_y6xvhkczvjdslpwrorji4thpga 154 9 , , , work_y6xvhkczvjdslpwrorji4thpga 154 10 it -PRON- PRP work_y6xvhkczvjdslpwrorji4thpga 154 11 became become VBD work_y6xvhkczvjdslpwrorji4thpga 154 12 apparent apparent JJ work_y6xvhkczvjdslpwrorji4thpga 154 13 that that IN work_y6xvhkczvjdslpwrorji4thpga 154 14 the the DT work_y6xvhkczvjdslpwrorji4thpga 154 15 100- 100- NNS work_y6xvhkczvjdslpwrorji4thpga 154 16 and and CC work_y6xvhkczvjdslpwrorji4thpga 154 17 200-kd 200-kd CD work_y6xvhkczvjdslpwrorji4thpga 154 18 bands band NNS work_y6xvhkczvjdslpwrorji4thpga 154 19 were be VBD work_y6xvhkczvjdslpwrorji4thpga 154 20 quite quite RB work_y6xvhkczvjdslpwrorji4thpga 154 21 similar similar JJ work_y6xvhkczvjdslpwrorji4thpga 154 22 to to IN work_y6xvhkczvjdslpwrorji4thpga 154 23 those those DT work_y6xvhkczvjdslpwrorji4thpga 154 24 seen see VBN work_y6xvhkczvjdslpwrorji4thpga 154 25 in in IN work_y6xvhkczvjdslpwrorji4thpga 154 26 immunoprecipitations immunoprecipitation NNS work_y6xvhkczvjdslpwrorji4thpga 154 27 of of IN work_y6xvhkczvjdslpwrorji4thpga 154 28 the the DT work_y6xvhkczvjdslpwrorji4thpga 154 29 transfer- transfer- NNP work_y6xvhkczvjdslpwrorji4thpga 154 30 rin rin NN work_y6xvhkczvjdslpwrorji4thpga 154 31 receptor receptor NN work_y6xvhkczvjdslpwrorji4thpga 154 32 ( ( -LRB- work_y6xvhkczvjdslpwrorji4thpga 154 33 TfR TfR NNP work_y6xvhkczvjdslpwrorji4thpga 154 34 ) ) -RRB- work_y6xvhkczvjdslpwrorji4thpga 154 35 , , , work_y6xvhkczvjdslpwrorji4thpga 154 36 which which WDT work_y6xvhkczvjdslpwrorji4thpga 154 37 can can MD work_y6xvhkczvjdslpwrorji4thpga 154 38 migrate migrate VB work_y6xvhkczvjdslpwrorji4thpga 154 39 as as IN work_y6xvhkczvjdslpwrorji4thpga 154 40 a a DT work_y6xvhkczvjdslpwrorji4thpga 154 41 dimer dimer NN work_y6xvhkczvjdslpwrorji4thpga 154 42 as as RB work_y6xvhkczvjdslpwrorji4thpga 154 43 well well RB work_y6xvhkczvjdslpwrorji4thpga 154 44 as as IN work_y6xvhkczvjdslpwrorji4thpga 154 45 in in IN work_y6xvhkczvjdslpwrorji4thpga 154 46 a a DT work_y6xvhkczvjdslpwrorji4thpga 154 47 monomeric monomeric JJ work_y6xvhkczvjdslpwrorji4thpga 154 48 form form NN work_y6xvhkczvjdslpwrorji4thpga 154 49 of of IN work_y6xvhkczvjdslpwrorji4thpga 154 50 approximately approximately RB work_y6xvhkczvjdslpwrorji4thpga 154 51 100 100 CD work_y6xvhkczvjdslpwrorji4thpga 154 52 kd kd NNS work_y6xvhkczvjdslpwrorji4thpga 154 53 . . . work_y6xvhkczvjdslpwrorji4thpga 155 1 The the DT work_y6xvhkczvjdslpwrorji4thpga 155 2 identity identity NN work_y6xvhkczvjdslpwrorji4thpga 155 3 of of IN work_y6xvhkczvjdslpwrorji4thpga 155 4 890 890 CD work_y6xvhkczvjdslpwrorji4thpga 155 5 HEPATOLOGY HEPATOLOGY NNP work_y6xvhkczvjdslpwrorji4thpga 155 6 Elsewhere elsewhere RB work_y6xvhkczvjdslpwrorji4thpga 155 7 HEPATOLOGY HEPATOLOGY NNP work_y6xvhkczvjdslpwrorji4thpga 155 8 September September NNP work_y6xvhkczvjdslpwrorji4thpga 155 9 1998 1998 CD