id sid tid token lemma pos work_rdyppa4isra3dorthbk5454hem 1 1 SHORT SHORT NNP work_rdyppa4isra3dorthbk5454hem 1 2 REPORT REPORT NNP work_rdyppa4isra3dorthbk5454hem 1 3 Disruption Disruption NNP work_rdyppa4isra3dorthbk5454hem 1 4 of of IN work_rdyppa4isra3dorthbk5454hem 1 5 the the DT work_rdyppa4isra3dorthbk5454hem 1 6 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 1 7 gene gene NN work_rdyppa4isra3dorthbk5454hem 1 8 in in IN work_rdyppa4isra3dorthbk5454hem 1 9 a a DT work_rdyppa4isra3dorthbk5454hem 1 10 t(7;15 t(7;15 NN work_rdyppa4isra3dorthbk5454hem 1 11 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 1 12 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 1 13 family family NN work_rdyppa4isra3dorthbk5454hem 1 14 without without IN work_rdyppa4isra3dorthbk5454hem 1 15 symptoms symptom NNS work_rdyppa4isra3dorthbk5454hem 1 16 of of IN work_rdyppa4isra3dorthbk5454hem 1 17 Gilles Gilles NNP work_rdyppa4isra3dorthbk5454hem 1 18 de de FW work_rdyppa4isra3dorthbk5454hem 1 19 la la NNP work_rdyppa4isra3dorthbk5454hem 1 20 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 1 21 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 1 22 Jose Jose NNP work_rdyppa4isra3dorthbk5454hem 1 23 M M NNP work_rdyppa4isra3dorthbk5454hem 1 24 Belloso1,2,3 Belloso1,2,3 NNP work_rdyppa4isra3dorthbk5454hem 1 25 , , , work_rdyppa4isra3dorthbk5454hem 1 26 Iben Iben NNP work_rdyppa4isra3dorthbk5454hem 1 27 Bache1 Bache1 NNP work_rdyppa4isra3dorthbk5454hem 1 28 , , , work_rdyppa4isra3dorthbk5454hem 1 29 Miriam Miriam NNP work_rdyppa4isra3dorthbk5454hem 1 30 Guitart2 Guitart2 NNP work_rdyppa4isra3dorthbk5454hem 1 31 , , , work_rdyppa4isra3dorthbk5454hem 1 32 Maria Maria NNP work_rdyppa4isra3dorthbk5454hem 1 33 Rosa Rosa NNP work_rdyppa4isra3dorthbk5454hem 1 34 Caballin3 Caballin3 NNP work_rdyppa4isra3dorthbk5454hem 1 35 , , , work_rdyppa4isra3dorthbk5454hem 1 36 Christina Christina NNP work_rdyppa4isra3dorthbk5454hem 1 37 Halgren1 Halgren1 NNP work_rdyppa4isra3dorthbk5454hem 1 38 , , , work_rdyppa4isra3dorthbk5454hem 1 39 Maria Maria NNP work_rdyppa4isra3dorthbk5454hem 1 40 Kirchhoff4 Kirchhoff4 NNP work_rdyppa4isra3dorthbk5454hem 1 41 , , , work_rdyppa4isra3dorthbk5454hem 1 42 Hans Hans NNP work_rdyppa4isra3dorthbk5454hem 1 43 - - HYPH work_rdyppa4isra3dorthbk5454hem 1 44 Hilger Hilger NNP work_rdyppa4isra3dorthbk5454hem 1 45 Ropers5 Ropers5 NNP work_rdyppa4isra3dorthbk5454hem 1 46 , , , work_rdyppa4isra3dorthbk5454hem 1 47 Niels Niels NNP work_rdyppa4isra3dorthbk5454hem 1 48 Tommerup1 Tommerup1 NNP work_rdyppa4isra3dorthbk5454hem 1 49 and and CC work_rdyppa4isra3dorthbk5454hem 1 50 Zeynep Zeynep NNP work_rdyppa4isra3dorthbk5454hem 1 51 Tümer*,1 Tümer*,1 NNP work_rdyppa4isra3dorthbk5454hem 1 52 1Department 1department CD work_rdyppa4isra3dorthbk5454hem 1 53 of of IN work_rdyppa4isra3dorthbk5454hem 1 54 Cellular Cellular NNP work_rdyppa4isra3dorthbk5454hem 1 55 and and CC work_rdyppa4isra3dorthbk5454hem 1 56 Molecular Molecular NNP work_rdyppa4isra3dorthbk5454hem 1 57 Medicine Medicine NNP work_rdyppa4isra3dorthbk5454hem 1 58 , , , work_rdyppa4isra3dorthbk5454hem 1 59 Wilhelm Wilhelm NNP work_rdyppa4isra3dorthbk5454hem 1 60 Johannsen Johannsen NNP work_rdyppa4isra3dorthbk5454hem 1 61 Centre Centre NNP work_rdyppa4isra3dorthbk5454hem 1 62 for for IN work_rdyppa4isra3dorthbk5454hem 1 63 Functional Functional NNP work_rdyppa4isra3dorthbk5454hem 1 64 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 1 65 Research Research NNP work_rdyppa4isra3dorthbk5454hem 1 66 , , , work_rdyppa4isra3dorthbk5454hem 1 67 The the DT work_rdyppa4isra3dorthbk5454hem 1 68 Panum Panum NNP work_rdyppa4isra3dorthbk5454hem 1 69 Institute Institute NNP work_rdyppa4isra3dorthbk5454hem 1 70 , , , work_rdyppa4isra3dorthbk5454hem 1 71 University University NNP work_rdyppa4isra3dorthbk5454hem 1 72 of of IN work_rdyppa4isra3dorthbk5454hem 1 73 Copenhagen Copenhagen NNP work_rdyppa4isra3dorthbk5454hem 1 74 , , , work_rdyppa4isra3dorthbk5454hem 1 75 Copenhagen Copenhagen NNP work_rdyppa4isra3dorthbk5454hem 1 76 , , , work_rdyppa4isra3dorthbk5454hem 1 77 Denmark Denmark NNP work_rdyppa4isra3dorthbk5454hem 1 78 ; ; : work_rdyppa4isra3dorthbk5454hem 1 79 2Laboratori 2Laboratori NNP work_rdyppa4isra3dorthbk5454hem 1 80 de de FW work_rdyppa4isra3dorthbk5454hem 1 81 Genètica Genètica NNP work_rdyppa4isra3dorthbk5454hem 1 82 , , , work_rdyppa4isra3dorthbk5454hem 1 83 UDIAT UDIAT NNP work_rdyppa4isra3dorthbk5454hem 1 84 - - HYPH work_rdyppa4isra3dorthbk5454hem 1 85 Centre Centre NNP work_rdyppa4isra3dorthbk5454hem 1 86 Diagnòstic Diagnòstic NNP work_rdyppa4isra3dorthbk5454hem 1 87 , , , work_rdyppa4isra3dorthbk5454hem 1 88 Hospital Hospital NNP work_rdyppa4isra3dorthbk5454hem 1 89 de de NNP work_rdyppa4isra3dorthbk5454hem 1 90 Sabadell Sabadell NNP work_rdyppa4isra3dorthbk5454hem 1 91 , , , work_rdyppa4isra3dorthbk5454hem 1 92 Corporació Corporació NNP work_rdyppa4isra3dorthbk5454hem 1 93 Sanitària Sanitària : work_rdyppa4isra3dorthbk5454hem 1 94 Parc Parc NNP work_rdyppa4isra3dorthbk5454hem 1 95 Taulı́ Taulı́ NNP work_rdyppa4isra3dorthbk5454hem 1 96 , , , work_rdyppa4isra3dorthbk5454hem 1 97 Fundació Fundació NNP work_rdyppa4isra3dorthbk5454hem 1 98 Parc Parc NNP work_rdyppa4isra3dorthbk5454hem 1 99 Taulı́ Taulı́ NNP work_rdyppa4isra3dorthbk5454hem 1 100 Institut Institut NNP work_rdyppa4isra3dorthbk5454hem 1 101 Universitari Universitari NNP work_rdyppa4isra3dorthbk5454hem 1 102 UAB UAB NNP work_rdyppa4isra3dorthbk5454hem 1 103 , , , work_rdyppa4isra3dorthbk5454hem 1 104 Sabadell Sabadell NNP work_rdyppa4isra3dorthbk5454hem 1 105 , , , work_rdyppa4isra3dorthbk5454hem 1 106 Spain Spain NNP work_rdyppa4isra3dorthbk5454hem 1 107 ; ; : work_rdyppa4isra3dorthbk5454hem 1 108 3Unitat 3unitat CD work_rdyppa4isra3dorthbk5454hem 1 109 d’Antropologia d’Antropologia NNP work_rdyppa4isra3dorthbk5454hem 1 110 , , , work_rdyppa4isra3dorthbk5454hem 1 111 Universitat Universitat NNP work_rdyppa4isra3dorthbk5454hem 1 112 Autònoma Autònoma NNP work_rdyppa4isra3dorthbk5454hem 1 113 de de IN work_rdyppa4isra3dorthbk5454hem 1 114 Barcelona Barcelona NNP work_rdyppa4isra3dorthbk5454hem 1 115 , , , work_rdyppa4isra3dorthbk5454hem 1 116 Cerdanyola Cerdanyola NNP work_rdyppa4isra3dorthbk5454hem 1 117 , , , work_rdyppa4isra3dorthbk5454hem 1 118 Spain Spain NNP work_rdyppa4isra3dorthbk5454hem 1 119 ; ; : work_rdyppa4isra3dorthbk5454hem 1 120 4Department 4department NN work_rdyppa4isra3dorthbk5454hem 1 121 of of IN work_rdyppa4isra3dorthbk5454hem 1 122 Clinical Clinical NNP work_rdyppa4isra3dorthbk5454hem 1 123 Genetics Genetics NNPS work_rdyppa4isra3dorthbk5454hem 1 124 , , , work_rdyppa4isra3dorthbk5454hem 1 125 Rigshospitalet Rigshospitalet NNP work_rdyppa4isra3dorthbk5454hem 1 126 , , , work_rdyppa4isra3dorthbk5454hem 1 127 Copenhagen Copenhagen NNP work_rdyppa4isra3dorthbk5454hem 1 128 , , , work_rdyppa4isra3dorthbk5454hem 1 129 Denmark Denmark NNP work_rdyppa4isra3dorthbk5454hem 1 130 ; ; : work_rdyppa4isra3dorthbk5454hem 1 131 5Max 5max CD work_rdyppa4isra3dorthbk5454hem 1 132 - - HYPH work_rdyppa4isra3dorthbk5454hem 1 133 Planck Planck NNP work_rdyppa4isra3dorthbk5454hem 1 134 Institute Institute NNP work_rdyppa4isra3dorthbk5454hem 1 135 for for IN work_rdyppa4isra3dorthbk5454hem 1 136 Molecular Molecular NNP work_rdyppa4isra3dorthbk5454hem 1 137 Genetics Genetics NNPS work_rdyppa4isra3dorthbk5454hem 1 138 , , , work_rdyppa4isra3dorthbk5454hem 1 139 Berlin Berlin NNP work_rdyppa4isra3dorthbk5454hem 1 140 , , , work_rdyppa4isra3dorthbk5454hem 1 141 Germany Germany NNP work_rdyppa4isra3dorthbk5454hem 1 142 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 1 143 is be VBZ work_rdyppa4isra3dorthbk5454hem 1 144 a a DT work_rdyppa4isra3dorthbk5454hem 1 145 member member NN work_rdyppa4isra3dorthbk5454hem 1 146 of of IN work_rdyppa4isra3dorthbk5454hem 1 147 neurexin neurexin NNP work_rdyppa4isra3dorthbk5454hem 1 148 superfamily superfamily RB work_rdyppa4isra3dorthbk5454hem 1 149 , , , work_rdyppa4isra3dorthbk5454hem 1 150 members member NNS work_rdyppa4isra3dorthbk5454hem 1 151 of of IN work_rdyppa4isra3dorthbk5454hem 1 152 which which WDT work_rdyppa4isra3dorthbk5454hem 1 153 are be VBP work_rdyppa4isra3dorthbk5454hem 1 154 transmembrane transmembrane JJ work_rdyppa4isra3dorthbk5454hem 1 155 proteins protein NNS work_rdyppa4isra3dorthbk5454hem 1 156 that that WDT work_rdyppa4isra3dorthbk5454hem 1 157 mediate mediate VBP work_rdyppa4isra3dorthbk5454hem 1 158 cellular cellular JJ work_rdyppa4isra3dorthbk5454hem 1 159 interactions interaction NNS work_rdyppa4isra3dorthbk5454hem 1 160 in in IN work_rdyppa4isra3dorthbk5454hem 1 161 the the DT work_rdyppa4isra3dorthbk5454hem 1 162 nervous nervous JJ work_rdyppa4isra3dorthbk5454hem 1 163 system system NN work_rdyppa4isra3dorthbk5454hem 1 164 . . . work_rdyppa4isra3dorthbk5454hem 2 1 Recently recently RB work_rdyppa4isra3dorthbk5454hem 2 2 , , , work_rdyppa4isra3dorthbk5454hem 2 3 truncation truncation NN work_rdyppa4isra3dorthbk5454hem 2 4 of of IN work_rdyppa4isra3dorthbk5454hem 2 5 the the DT work_rdyppa4isra3dorthbk5454hem 2 6 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 2 7 gene gene NN work_rdyppa4isra3dorthbk5454hem 2 8 coding code VBG work_rdyppa4isra3dorthbk5454hem 2 9 for for IN work_rdyppa4isra3dorthbk5454hem 2 10 the the DT work_rdyppa4isra3dorthbk5454hem 2 11 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 2 12 protein protein NN work_rdyppa4isra3dorthbk5454hem 2 13 has have VBZ work_rdyppa4isra3dorthbk5454hem 2 14 been be VBN work_rdyppa4isra3dorthbk5454hem 2 15 suggested suggest VBN work_rdyppa4isra3dorthbk5454hem 2 16 to to TO work_rdyppa4isra3dorthbk5454hem 2 17 be be VB work_rdyppa4isra3dorthbk5454hem 2 18 associated associate VBN work_rdyppa4isra3dorthbk5454hem 2 19 with with IN work_rdyppa4isra3dorthbk5454hem 2 20 the the DT work_rdyppa4isra3dorthbk5454hem 2 21 Gilles Gilles NNP work_rdyppa4isra3dorthbk5454hem 2 22 de de FW work_rdyppa4isra3dorthbk5454hem 2 23 la la NNP work_rdyppa4isra3dorthbk5454hem 2 24 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 2 25 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 2 26 , , , work_rdyppa4isra3dorthbk5454hem 2 27 a a DT work_rdyppa4isra3dorthbk5454hem 2 28 neurological neurological JJ work_rdyppa4isra3dorthbk5454hem 2 29 disorder disorder NN work_rdyppa4isra3dorthbk5454hem 2 30 characterized characterize VBN work_rdyppa4isra3dorthbk5454hem 2 31 by by IN work_rdyppa4isra3dorthbk5454hem 2 32 motor motor NN work_rdyppa4isra3dorthbk5454hem 2 33 and and CC work_rdyppa4isra3dorthbk5454hem 2 34 vocal vocal NNP work_rdyppa4isra3dorthbk5454hem 2 35 tics tic NNS work_rdyppa4isra3dorthbk5454hem 2 36 , , , work_rdyppa4isra3dorthbk5454hem 2 37 and and CC work_rdyppa4isra3dorthbk5454hem 2 38 behavioral behavioral JJ work_rdyppa4isra3dorthbk5454hem 2 39 anomalies anomaly NNS work_rdyppa4isra3dorthbk5454hem 2 40 . . . work_rdyppa4isra3dorthbk5454hem 3 1 In in IN work_rdyppa4isra3dorthbk5454hem 3 2 this this DT work_rdyppa4isra3dorthbk5454hem 3 3 study study NN work_rdyppa4isra3dorthbk5454hem 3 4 , , , work_rdyppa4isra3dorthbk5454hem 3 5 we -PRON- PRP work_rdyppa4isra3dorthbk5454hem 3 6 describe describe VBP work_rdyppa4isra3dorthbk5454hem 3 7 a a DT work_rdyppa4isra3dorthbk5454hem 3 8 familial familial JJ work_rdyppa4isra3dorthbk5454hem 3 9 balanced balanced JJ work_rdyppa4isra3dorthbk5454hem 3 10 reciprocal reciprocal JJ work_rdyppa4isra3dorthbk5454hem 3 11 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 3 12 t(7;15)(q35;q26.1 t(7;15)(q35;q26.1 NNP work_rdyppa4isra3dorthbk5454hem 3 13 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 3 14 in in IN work_rdyppa4isra3dorthbk5454hem 3 15 phenotypically phenotypically RB work_rdyppa4isra3dorthbk5454hem 3 16 normal normal JJ work_rdyppa4isra3dorthbk5454hem 3 17 individuals individual NNS work_rdyppa4isra3dorthbk5454hem 3 18 . . . work_rdyppa4isra3dorthbk5454hem 4 1 The the DT work_rdyppa4isra3dorthbk5454hem 4 2 7q35 7q35 CD work_rdyppa4isra3dorthbk5454hem 4 3 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 4 4 disrupts disrupt VBZ work_rdyppa4isra3dorthbk5454hem 4 5 the the DT work_rdyppa4isra3dorthbk5454hem 4 6 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 4 7 gene gene NN work_rdyppa4isra3dorthbk5454hem 4 8 , , , work_rdyppa4isra3dorthbk5454hem 4 9 indicating indicate VBG work_rdyppa4isra3dorthbk5454hem 4 10 that that IN work_rdyppa4isra3dorthbk5454hem 4 11 truncation truncation NN work_rdyppa4isra3dorthbk5454hem 4 12 of of IN work_rdyppa4isra3dorthbk5454hem 4 13 this this DT work_rdyppa4isra3dorthbk5454hem 4 14 gene gene NN work_rdyppa4isra3dorthbk5454hem 4 15 does do VBZ work_rdyppa4isra3dorthbk5454hem 4 16 not not RB work_rdyppa4isra3dorthbk5454hem 4 17 necessarily necessarily RB work_rdyppa4isra3dorthbk5454hem 4 18 lead lead VB work_rdyppa4isra3dorthbk5454hem 4 19 to to IN work_rdyppa4isra3dorthbk5454hem 4 20 the the DT work_rdyppa4isra3dorthbk5454hem 4 21 symptoms symptom NNS work_rdyppa4isra3dorthbk5454hem 4 22 of of IN work_rdyppa4isra3dorthbk5454hem 4 23 the the DT work_rdyppa4isra3dorthbk5454hem 4 24 complex complex JJ work_rdyppa4isra3dorthbk5454hem 4 25 Gilles Gilles NNP work_rdyppa4isra3dorthbk5454hem 4 26 de de FW work_rdyppa4isra3dorthbk5454hem 4 27 la la FW work_rdyppa4isra3dorthbk5454hem 4 28 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 4 29 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 4 30 . . . work_rdyppa4isra3dorthbk5454hem 5 1 European European NNP work_rdyppa4isra3dorthbk5454hem 5 2 Journal Journal NNP work_rdyppa4isra3dorthbk5454hem 5 3 of of IN work_rdyppa4isra3dorthbk5454hem 5 4 Human Human NNP work_rdyppa4isra3dorthbk5454hem 5 5 Genetics Genetics NNPS work_rdyppa4isra3dorthbk5454hem 5 6 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 5 7 2007 2007 CD work_rdyppa4isra3dorthbk5454hem 5 8 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 5 9 15 15 CD work_rdyppa4isra3dorthbk5454hem 5 10 , , , work_rdyppa4isra3dorthbk5454hem 5 11 711–713 711–713 CD work_rdyppa4isra3dorthbk5454hem 5 12 . . . work_rdyppa4isra3dorthbk5454hem 6 1 doi:10.1038 doi:10.1038 NNP work_rdyppa4isra3dorthbk5454hem 6 2 / / SYM work_rdyppa4isra3dorthbk5454hem 6 3 sj.ejhg.5201824 sj.ejhg.5201824 NNP work_rdyppa4isra3dorthbk5454hem 6 4 ; ; : work_rdyppa4isra3dorthbk5454hem 6 5 published publish VBN work_rdyppa4isra3dorthbk5454hem 6 6 online online RB work_rdyppa4isra3dorthbk5454hem 6 7 28 28 CD work_rdyppa4isra3dorthbk5454hem 6 8 March March NNP work_rdyppa4isra3dorthbk5454hem 6 9 2007 2007 CD work_rdyppa4isra3dorthbk5454hem 6 10 Keywords Keywords NNPS work_rdyppa4isra3dorthbk5454hem 6 11 : : : work_rdyppa4isra3dorthbk5454hem 6 12 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 6 13 ; ; : work_rdyppa4isra3dorthbk5454hem 6 14 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 6 15 7 7 CD work_rdyppa4isra3dorthbk5454hem 6 16 ; ; : work_rdyppa4isra3dorthbk5454hem 6 17 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 6 18 ; ; : work_rdyppa4isra3dorthbk5454hem 6 19 cortical cortical JJ work_rdyppa4isra3dorthbk5454hem 6 20 dysplasia dysplasia JJ work_rdyppa4isra3dorthbk5454hem 6 21 - - HYPH work_rdyppa4isra3dorthbk5454hem 6 22 focal focal JJ work_rdyppa4isra3dorthbk5454hem 6 23 epilepsy epilepsy NN work_rdyppa4isra3dorthbk5454hem 6 24 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 6 25 ; ; : work_rdyppa4isra3dorthbk5454hem 6 26 Gilles Gilles NNP work_rdyppa4isra3dorthbk5454hem 6 27 de de IN work_rdyppa4isra3dorthbk5454hem 6 28 la la NNP work_rdyppa4isra3dorthbk5454hem 6 29 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 6 30 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 6 31 ; ; : work_rdyppa4isra3dorthbk5454hem 6 32 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 6 33 Introduction introduction NN work_rdyppa4isra3dorthbk5454hem 6 34 CNTNAP2 CNTNAP2 NNS work_rdyppa4isra3dorthbk5454hem 6 35 encodes encode VBZ work_rdyppa4isra3dorthbk5454hem 6 36 contactin contactin NN work_rdyppa4isra3dorthbk5454hem 6 37 - - HYPH work_rdyppa4isra3dorthbk5454hem 6 38 associated associate VBN work_rdyppa4isra3dorthbk5454hem 6 39 protein protein NN work_rdyppa4isra3dorthbk5454hem 6 40 - - HYPH work_rdyppa4isra3dorthbk5454hem 6 41 like like JJ work_rdyppa4isra3dorthbk5454hem 6 42 2 2 CD work_rdyppa4isra3dorthbk5454hem 6 43 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 6 44 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 6 45 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 6 46 , , , work_rdyppa4isra3dorthbk5454hem 6 47 which which WDT work_rdyppa4isra3dorthbk5454hem 6 48 is be VBZ work_rdyppa4isra3dorthbk5454hem 6 49 localized localize VBN work_rdyppa4isra3dorthbk5454hem 6 50 to to IN work_rdyppa4isra3dorthbk5454hem 6 51 the the DT work_rdyppa4isra3dorthbk5454hem 6 52 juxtaparanodal juxtaparanodal JJ work_rdyppa4isra3dorthbk5454hem 6 53 regions region NNS work_rdyppa4isra3dorthbk5454hem 6 54 at at IN work_rdyppa4isra3dorthbk5454hem 6 55 the the DT work_rdyppa4isra3dorthbk5454hem 6 56 node node NN work_rdyppa4isra3dorthbk5454hem 6 57 of of IN work_rdyppa4isra3dorthbk5454hem 6 58 Ranvier Ranvier NNP work_rdyppa4isra3dorthbk5454hem 6 59 of of IN work_rdyppa4isra3dorthbk5454hem 6 60 myelinated myelinated JJ work_rdyppa4isra3dorthbk5454hem 6 61 axons.1 axons.1 NNP work_rdyppa4isra3dorthbk5454hem 6 62 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 6 63 is be VBZ work_rdyppa4isra3dorthbk5454hem 6 64 colocalized colocalized JJ work_rdyppa4isra3dorthbk5454hem 6 65 and and CC work_rdyppa4isra3dorthbk5454hem 6 66 physically physically RB work_rdyppa4isra3dorthbk5454hem 6 67 associated associate VBN work_rdyppa4isra3dorthbk5454hem 6 68 with with IN work_rdyppa4isra3dorthbk5454hem 6 69 Shaker Shaker NNP work_rdyppa4isra3dorthbk5454hem 6 70 - - HYPH work_rdyppa4isra3dorthbk5454hem 6 71 type type NN work_rdyppa4isra3dorthbk5454hem 6 72 voltage voltage NN work_rdyppa4isra3dorthbk5454hem 6 73 - - HYPH work_rdyppa4isra3dorthbk5454hem 6 74 activated activate VBN work_rdyppa4isra3dorthbk5454hem 6 75 Kþ Kþ NNP work_rdyppa4isra3dorthbk5454hem 6 76 channels channel NNS work_rdyppa4isra3dorthbk5454hem 6 77 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 6 78 Kv1).2 Kv1).2 NFP work_rdyppa4isra3dorthbk5454hem 6 79 Studies study NNS work_rdyppa4isra3dorthbk5454hem 6 80 with with IN work_rdyppa4isra3dorthbk5454hem 6 81 Caspr2-null caspr2-null JJ work_rdyppa4isra3dorthbk5454hem 6 82 mice mouse NNS work_rdyppa4isra3dorthbk5454hem 6 83 suggest suggest VBP work_rdyppa4isra3dorthbk5454hem 6 84 that that IN work_rdyppa4isra3dorthbk5454hem 6 85 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 6 86 is be VBZ work_rdyppa4isra3dorthbk5454hem 6 87 necessary necessary JJ work_rdyppa4isra3dorthbk5454hem 6 88 for for IN work_rdyppa4isra3dorthbk5454hem 6 89 localization localization NN work_rdyppa4isra3dorthbk5454hem 6 90 and/or and/or CC work_rdyppa4isra3dorthbk5454hem 6 91 maintenance maintenance NN work_rdyppa4isra3dorthbk5454hem 6 92 of of IN work_rdyppa4isra3dorthbk5454hem 6 93 Kv1 Kv1 NNS work_rdyppa4isra3dorthbk5454hem 6 94 channels.3 channels.3 CD work_rdyppa4isra3dorthbk5454hem 6 95 The the DT work_rdyppa4isra3dorthbk5454hem 6 96 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 6 97 gene gene NN work_rdyppa4isra3dorthbk5454hem 6 98 resides reside VBZ work_rdyppa4isra3dorthbk5454hem 6 99 at at IN work_rdyppa4isra3dorthbk5454hem 6 100 7q35-q36.1 7q35-q36.1 CD work_rdyppa4isra3dorthbk5454hem 6 101 and and CC work_rdyppa4isra3dorthbk5454hem 6 102 consists consist VBZ work_rdyppa4isra3dorthbk5454hem 6 103 of of IN work_rdyppa4isra3dorthbk5454hem 6 104 25 25 CD work_rdyppa4isra3dorthbk5454hem 6 105 exons exon NNS work_rdyppa4isra3dorthbk5454hem 6 106 , , , work_rdyppa4isra3dorthbk5454hem 6 107 covering cover VBG work_rdyppa4isra3dorthbk5454hem 6 108 an an DT work_rdyppa4isra3dorthbk5454hem 6 109 approximately approximately RB work_rdyppa4isra3dorthbk5454hem 6 110 2.3-Mb 2.3-mb CD work_rdyppa4isra3dorthbk5454hem 6 111 genomic genomic JJ work_rdyppa4isra3dorthbk5454hem 6 112 region region NN work_rdyppa4isra3dorthbk5454hem 6 113 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 6 114 Figure figure NN work_rdyppa4isra3dorthbk5454hem 6 115 1a 1a NN work_rdyppa4isra3dorthbk5454hem 6 116 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 6 117 . . . work_rdyppa4isra3dorthbk5454hem 7 1 Representing represent VBG work_rdyppa4isra3dorthbk5454hem 7 2 1.5 1.5 CD work_rdyppa4isra3dorthbk5454hem 7 3 % % NN work_rdyppa4isra3dorthbk5454hem 7 4 of of IN work_rdyppa4isra3dorthbk5454hem 7 5 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 7 6 7 7 CD work_rdyppa4isra3dorthbk5454hem 7 7 , , , work_rdyppa4isra3dorthbk5454hem 7 8 it -PRON- PRP work_rdyppa4isra3dorthbk5454hem 7 9 is be VBZ work_rdyppa4isra3dorthbk5454hem 7 10 one one CD work_rdyppa4isra3dorthbk5454hem 7 11 of of IN work_rdyppa4isra3dorthbk5454hem 7 12 the the DT work_rdyppa4isra3dorthbk5454hem 7 13 largest large JJS work_rdyppa4isra3dorthbk5454hem 7 14 genes gene NNS work_rdyppa4isra3dorthbk5454hem 7 15 in in IN work_rdyppa4isra3dorthbk5454hem 7 16 the the DT work_rdyppa4isra3dorthbk5454hem 7 17 human human JJ work_rdyppa4isra3dorthbk5454hem 7 18 genome.4 genome.4 NNP work_rdyppa4isra3dorthbk5454hem 7 19 Mutations Mutations NNPS work_rdyppa4isra3dorthbk5454hem 7 20 in in IN work_rdyppa4isra3dorthbk5454hem 7 21 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 7 22 have have VBP work_rdyppa4isra3dorthbk5454hem 7 23 been be VBN work_rdyppa4isra3dorthbk5454hem 7 24 associated associate VBN work_rdyppa4isra3dorthbk5454hem 7 25 with with IN work_rdyppa4isra3dorthbk5454hem 7 26 two two CD work_rdyppa4isra3dorthbk5454hem 7 27 distinct distinct JJ work_rdyppa4isra3dorthbk5454hem 7 28 neurological neurological JJ work_rdyppa4isra3dorthbk5454hem 7 29 disorders disorder NNS work_rdyppa4isra3dorthbk5454hem 7 30 : : : work_rdyppa4isra3dorthbk5454hem 7 31 cortical cortical JJ work_rdyppa4isra3dorthbk5454hem 7 32 dysplasia dysplasia JJ work_rdyppa4isra3dorthbk5454hem 7 33 - - HYPH work_rdyppa4isra3dorthbk5454hem 7 34 focal focal JJ work_rdyppa4isra3dorthbk5454hem 7 35 epilepsy epilepsy NN work_rdyppa4isra3dorthbk5454hem 7 36 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 7 37 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 7 38 CDFE CDFE NNP work_rdyppa4isra3dorthbk5454hem 7 39 , , , work_rdyppa4isra3dorthbk5454hem 7 40 OMIM OMIM NNP work_rdyppa4isra3dorthbk5454hem 7 41 610042)5 610042)5 CD work_rdyppa4isra3dorthbk5454hem 7 42 and and CC work_rdyppa4isra3dorthbk5454hem 7 43 Gilles Gilles NNP work_rdyppa4isra3dorthbk5454hem 7 44 de de FW work_rdyppa4isra3dorthbk5454hem 7 45 la la NNP work_rdyppa4isra3dorthbk5454hem 7 46 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 7 47 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 7 48 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 7 49 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 7 50 , , , work_rdyppa4isra3dorthbk5454hem 7 51 OMIM OMIM NNP work_rdyppa4isra3dorthbk5454hem 7 52 137580).6 137580).6 CD work_rdyppa4isra3dorthbk5454hem 7 53 CDFE CDFE NNP work_rdyppa4isra3dorthbk5454hem 7 54 is be VBZ work_rdyppa4isra3dorthbk5454hem 7 55 characterized characterize VBN work_rdyppa4isra3dorthbk5454hem 7 56 by by IN work_rdyppa4isra3dorthbk5454hem 7 57 cortical cortical JJ work_rdyppa4isra3dorthbk5454hem 7 58 dysplasia dysplasia NNS work_rdyppa4isra3dorthbk5454hem 7 59 , , , work_rdyppa4isra3dorthbk5454hem 7 60 focal focal JJ work_rdyppa4isra3dorthbk5454hem 7 61 epilepsy epilepsy NN work_rdyppa4isra3dorthbk5454hem 7 62 , , , work_rdyppa4isra3dorthbk5454hem 7 63 relative relative JJ work_rdyppa4isra3dorthbk5454hem 7 64 macrocephaly macrocephaly NNS work_rdyppa4isra3dorthbk5454hem 7 65 , , , work_rdyppa4isra3dorthbk5454hem 7 66 and and CC work_rdyppa4isra3dorthbk5454hem 7 67 diminished diminish VBD work_rdyppa4isra3dorthbk5454hem 7 68 deep deep JJ work_rdyppa4isra3dorthbk5454hem 7 69 - - HYPH work_rdyppa4isra3dorthbk5454hem 7 70 tendon tendon NNP work_rdyppa4isra3dorthbk5454hem 7 71 reflexes reflex NNS work_rdyppa4isra3dorthbk5454hem 7 72 . . . work_rdyppa4isra3dorthbk5454hem 8 1 Homozygous homozygous JJ work_rdyppa4isra3dorthbk5454hem 8 2 frame frame NN work_rdyppa4isra3dorthbk5454hem 8 3 - - HYPH work_rdyppa4isra3dorthbk5454hem 8 4 shift shift NN work_rdyppa4isra3dorthbk5454hem 8 5 mutations mutation NNS work_rdyppa4isra3dorthbk5454hem 8 6 of of IN work_rdyppa4isra3dorthbk5454hem 8 7 CNTNAP2 CNTNAP2 NNS work_rdyppa4isra3dorthbk5454hem 8 8 have have VBP work_rdyppa4isra3dorthbk5454hem 8 9 been be VBN work_rdyppa4isra3dorthbk5454hem 8 10 detected detect VBN work_rdyppa4isra3dorthbk5454hem 8 11 in in IN work_rdyppa4isra3dorthbk5454hem 8 12 CDFE CDFE NNP work_rdyppa4isra3dorthbk5454hem 8 13 patients patient NNS work_rdyppa4isra3dorthbk5454hem 8 14 in in IN work_rdyppa4isra3dorthbk5454hem 8 15 the the DT work_rdyppa4isra3dorthbk5454hem 8 16 Old Old NNP work_rdyppa4isra3dorthbk5454hem 8 17 Order order NN work_rdyppa4isra3dorthbk5454hem 8 18 Amish amish JJ work_rdyppa4isra3dorthbk5454hem 8 19 community community NN work_rdyppa4isra3dorthbk5454hem 8 20 . . . work_rdyppa4isra3dorthbk5454hem 9 1 Heterozygotes heterozygote NNS work_rdyppa4isra3dorthbk5454hem 9 2 did do VBD work_rdyppa4isra3dorthbk5454hem 9 3 not not RB work_rdyppa4isra3dorthbk5454hem 9 4 present present VB work_rdyppa4isra3dorthbk5454hem 9 5 symptoms symptom NNS work_rdyppa4isra3dorthbk5454hem 9 6 , , , work_rdyppa4isra3dorthbk5454hem 9 7 suggesting suggest VBG work_rdyppa4isra3dorthbk5454hem 9 8 a a DT work_rdyppa4isra3dorthbk5454hem 9 9 recessive recessive JJ work_rdyppa4isra3dorthbk5454hem 9 10 condition.5 condition.5 NNP work_rdyppa4isra3dorthbk5454hem 9 11 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 9 12 is be VBZ work_rdyppa4isra3dorthbk5454hem 9 13 a a DT work_rdyppa4isra3dorthbk5454hem 9 14 chronic chronic JJ work_rdyppa4isra3dorthbk5454hem 9 15 Received receive VBN work_rdyppa4isra3dorthbk5454hem 9 16 22 22 CD work_rdyppa4isra3dorthbk5454hem 9 17 November November NNP work_rdyppa4isra3dorthbk5454hem 9 18 2006 2006 CD work_rdyppa4isra3dorthbk5454hem 9 19 ; ; : work_rdyppa4isra3dorthbk5454hem 9 20 revised revise VBN work_rdyppa4isra3dorthbk5454hem 9 21 10 10 CD work_rdyppa4isra3dorthbk5454hem 9 22 February February NNP work_rdyppa4isra3dorthbk5454hem 9 23 2007 2007 CD work_rdyppa4isra3dorthbk5454hem 9 24 ; ; : work_rdyppa4isra3dorthbk5454hem 9 25 accepted accept VBD work_rdyppa4isra3dorthbk5454hem 9 26 14 14 CD work_rdyppa4isra3dorthbk5454hem 9 27 February February NNP work_rdyppa4isra3dorthbk5454hem 9 28 2007 2007 CD work_rdyppa4isra3dorthbk5454hem 9 29 ; ; , work_rdyppa4isra3dorthbk5454hem 9 30 published publish VBN work_rdyppa4isra3dorthbk5454hem 9 31 online online RB work_rdyppa4isra3dorthbk5454hem 9 32 28 28 CD work_rdyppa4isra3dorthbk5454hem 9 33 March March NNP work_rdyppa4isra3dorthbk5454hem 9 34 2007 2007 CD work_rdyppa4isra3dorthbk5454hem 9 35 * * NFP work_rdyppa4isra3dorthbk5454hem 9 36 Correspondence correspondence NN work_rdyppa4isra3dorthbk5454hem 9 37 : : : work_rdyppa4isra3dorthbk5454hem 9 38 Dr Dr NNP work_rdyppa4isra3dorthbk5454hem 9 39 Z Z NNP work_rdyppa4isra3dorthbk5454hem 9 40 Tümer Tümer NNP work_rdyppa4isra3dorthbk5454hem 9 41 , , , work_rdyppa4isra3dorthbk5454hem 9 42 Department Department NNP work_rdyppa4isra3dorthbk5454hem 9 43 of of IN work_rdyppa4isra3dorthbk5454hem 9 44 Cellular Cellular NNP work_rdyppa4isra3dorthbk5454hem 9 45 and and CC work_rdyppa4isra3dorthbk5454hem 9 46 Molecular Molecular NNP work_rdyppa4isra3dorthbk5454hem 9 47 Medicine Medicine NNP work_rdyppa4isra3dorthbk5454hem 9 48 , , , work_rdyppa4isra3dorthbk5454hem 9 49 Faculty Faculty NNP work_rdyppa4isra3dorthbk5454hem 9 50 of of IN work_rdyppa4isra3dorthbk5454hem 9 51 Health Health NNP work_rdyppa4isra3dorthbk5454hem 9 52 Sciences Sciences NNPS work_rdyppa4isra3dorthbk5454hem 9 53 , , , work_rdyppa4isra3dorthbk5454hem 9 54 Wilhelm Wilhelm NNP work_rdyppa4isra3dorthbk5454hem 9 55 Johannsen Johannsen NNP work_rdyppa4isra3dorthbk5454hem 9 56 Center Center NNP work_rdyppa4isra3dorthbk5454hem 9 57 for for IN work_rdyppa4isra3dorthbk5454hem 9 58 Functional Functional NNP work_rdyppa4isra3dorthbk5454hem 9 59 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 9 60 Research Research NNP work_rdyppa4isra3dorthbk5454hem 9 61 , , , work_rdyppa4isra3dorthbk5454hem 9 62 University University NNP work_rdyppa4isra3dorthbk5454hem 9 63 of of IN work_rdyppa4isra3dorthbk5454hem 9 64 Copenhagen Copenhagen NNP work_rdyppa4isra3dorthbk5454hem 9 65 , , , work_rdyppa4isra3dorthbk5454hem 9 66 Blegdamsvej Blegdamsvej NNP work_rdyppa4isra3dorthbk5454hem 9 67 3 3 CD work_rdyppa4isra3dorthbk5454hem 9 68 , , , work_rdyppa4isra3dorthbk5454hem 9 69 2200 2200 CD work_rdyppa4isra3dorthbk5454hem 9 70 KBH KBH NNP work_rdyppa4isra3dorthbk5454hem 9 71 N N NNP work_rdyppa4isra3dorthbk5454hem 9 72 , , , work_rdyppa4isra3dorthbk5454hem 9 73 Denmark Denmark NNP work_rdyppa4isra3dorthbk5454hem 9 74 . . . work_rdyppa4isra3dorthbk5454hem 10 1 Tel tel NN work_rdyppa4isra3dorthbk5454hem 10 2 . . . work_rdyppa4isra3dorthbk5454hem 11 1 : : : work_rdyppa4isra3dorthbk5454hem 11 2 þ þ DT work_rdyppa4isra3dorthbk5454hem 11 3 45 45 CD work_rdyppa4isra3dorthbk5454hem 11 4 3532 3532 CD work_rdyppa4isra3dorthbk5454hem 11 5 7827 7827 CD work_rdyppa4isra3dorthbk5454hem 11 6 ; ; : work_rdyppa4isra3dorthbk5454hem 11 7 Fax fax NN work_rdyppa4isra3dorthbk5454hem 11 8 : : : work_rdyppa4isra3dorthbk5454hem 11 9 þ þ NNP work_rdyppa4isra3dorthbk5454hem 11 10 45 45 CD work_rdyppa4isra3dorthbk5454hem 11 11 3532 3532 CD work_rdyppa4isra3dorthbk5454hem 11 12 7845 7845 CD work_rdyppa4isra3dorthbk5454hem 11 13 ; ; : work_rdyppa4isra3dorthbk5454hem 11 14 E e NN work_rdyppa4isra3dorthbk5454hem 11 15 - - NN work_rdyppa4isra3dorthbk5454hem 11 16 mail mail NN work_rdyppa4isra3dorthbk5454hem 11 17 : : : work_rdyppa4isra3dorthbk5454hem 11 18 zeynep@imbg.ku.dk zeynep@imbg.ku.dk NNP work_rdyppa4isra3dorthbk5454hem 11 19 European European NNP work_rdyppa4isra3dorthbk5454hem 11 20 Journal Journal NNP work_rdyppa4isra3dorthbk5454hem 11 21 of of IN work_rdyppa4isra3dorthbk5454hem 11 22 Human Human NNP work_rdyppa4isra3dorthbk5454hem 11 23 Genetics Genetics NNPS work_rdyppa4isra3dorthbk5454hem 11 24 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 11 25 2007 2007 CD work_rdyppa4isra3dorthbk5454hem 11 26 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 11 27 15 15 CD work_rdyppa4isra3dorthbk5454hem 11 28 , , , work_rdyppa4isra3dorthbk5454hem 11 29 711–713 711–713 CD work_rdyppa4isra3dorthbk5454hem 11 30 & & CC work_rdyppa4isra3dorthbk5454hem 11 31 2007 2007 CD work_rdyppa4isra3dorthbk5454hem 11 32 Nature Nature NNP work_rdyppa4isra3dorthbk5454hem 11 33 Publishing Publishing NNP work_rdyppa4isra3dorthbk5454hem 11 34 Group Group NNP work_rdyppa4isra3dorthbk5454hem 11 35 All All NNP work_rdyppa4isra3dorthbk5454hem 11 36 rights right NNS work_rdyppa4isra3dorthbk5454hem 11 37 reserved reserve VBD work_rdyppa4isra3dorthbk5454hem 11 38 1018 1018 CD work_rdyppa4isra3dorthbk5454hem 11 39 - - SYM work_rdyppa4isra3dorthbk5454hem 11 40 4813/07 4813/07 CD work_rdyppa4isra3dorthbk5454hem 11 41 $ $ $ work_rdyppa4isra3dorthbk5454hem 11 42 30.00 30.00 CD work_rdyppa4isra3dorthbk5454hem 11 43 www.nature.com/ejhg www.nature.com/ejhg NNP work_rdyppa4isra3dorthbk5454hem 11 44 neuropsychiatric neuropsychiatric NN work_rdyppa4isra3dorthbk5454hem 11 45 disorder disorder NN work_rdyppa4isra3dorthbk5454hem 11 46 characterized characterize VBN work_rdyppa4isra3dorthbk5454hem 11 47 by by IN work_rdyppa4isra3dorthbk5454hem 11 48 intermittent intermittent JJ work_rdyppa4isra3dorthbk5454hem 11 49 and and CC work_rdyppa4isra3dorthbk5454hem 11 50 involuntary involuntary JJ work_rdyppa4isra3dorthbk5454hem 11 51 motor motor NN work_rdyppa4isra3dorthbk5454hem 11 52 and and CC work_rdyppa4isra3dorthbk5454hem 11 53 vocal vocal NNP work_rdyppa4isra3dorthbk5454hem 11 54 tics tic NNS work_rdyppa4isra3dorthbk5454hem 11 55 beginning begin VBG work_rdyppa4isra3dorthbk5454hem 11 56 in in IN work_rdyppa4isra3dorthbk5454hem 11 57 child- child- NN work_rdyppa4isra3dorthbk5454hem 11 58 hood.7 hood.7 PDT work_rdyppa4isra3dorthbk5454hem 11 59 This this DT work_rdyppa4isra3dorthbk5454hem 11 60 phenotype phenotype NN work_rdyppa4isra3dorthbk5454hem 11 61 is be VBZ work_rdyppa4isra3dorthbk5454hem 11 62 associated associate VBN work_rdyppa4isra3dorthbk5454hem 11 63 frequently frequently RB work_rdyppa4isra3dorthbk5454hem 11 64 with with IN work_rdyppa4isra3dorthbk5454hem 11 65 behavioral behavioral JJ work_rdyppa4isra3dorthbk5454hem 11 66 , , , work_rdyppa4isra3dorthbk5454hem 11 67 emotional emotional JJ work_rdyppa4isra3dorthbk5454hem 11 68 and and CC work_rdyppa4isra3dorthbk5454hem 11 69 cognitive cognitive JJ work_rdyppa4isra3dorthbk5454hem 11 70 problems problem NNS work_rdyppa4isra3dorthbk5454hem 11 71 that that WDT work_rdyppa4isra3dorthbk5454hem 11 72 are be VBP work_rdyppa4isra3dorthbk5454hem 11 73 often often RB work_rdyppa4isra3dorthbk5454hem 11 74 more more RBR work_rdyppa4isra3dorthbk5454hem 11 75 incapacitating incapacitating JJ work_rdyppa4isra3dorthbk5454hem 11 76 than than IN work_rdyppa4isra3dorthbk5454hem 11 77 the the DT work_rdyppa4isra3dorthbk5454hem 11 78 tics tic NNS work_rdyppa4isra3dorthbk5454hem 11 79 . . . work_rdyppa4isra3dorthbk5454hem 12 1 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 12 2 is be VBZ work_rdyppa4isra3dorthbk5454hem 12 3 a a DT work_rdyppa4isra3dorthbk5454hem 12 4 complex complex JJ work_rdyppa4isra3dorthbk5454hem 12 5 disorder disorder NN work_rdyppa4isra3dorthbk5454hem 12 6 with with IN work_rdyppa4isra3dorthbk5454hem 12 7 a a DT work_rdyppa4isra3dorthbk5454hem 12 8 strong strong JJ work_rdyppa4isra3dorthbk5454hem 12 9 heritable heritable JJ work_rdyppa4isra3dorthbk5454hem 12 10 component.8 component.8 NN work_rdyppa4isra3dorthbk5454hem 12 11 Sequence sequence NN work_rdyppa4isra3dorthbk5454hem 12 12 variations variation NNS work_rdyppa4isra3dorthbk5454hem 12 13 of of IN work_rdyppa4isra3dorthbk5454hem 12 14 SLITRK1 SLITRK1 NNS work_rdyppa4isra3dorthbk5454hem 12 15 have have VBP work_rdyppa4isra3dorthbk5454hem 12 16 been be VBN work_rdyppa4isra3dorthbk5454hem 12 17 detected detect VBN work_rdyppa4isra3dorthbk5454hem 12 18 in in IN work_rdyppa4isra3dorthbk5454hem 12 19 a a DT work_rdyppa4isra3dorthbk5454hem 12 20 few few JJ work_rdyppa4isra3dorthbk5454hem 12 21 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 12 22 patients,9 patients,9 NNP work_rdyppa4isra3dorthbk5454hem 12 23 but but CC work_rdyppa4isra3dorthbk5454hem 12 24 the the DT work_rdyppa4isra3dorthbk5454hem 12 25 genetic genetic JJ work_rdyppa4isra3dorthbk5454hem 12 26 component component NN work_rdyppa4isra3dorthbk5454hem 12 27 in in IN work_rdyppa4isra3dorthbk5454hem 12 28 most most JJS work_rdyppa4isra3dorthbk5454hem 12 29 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 12 30 cases case NNS work_rdyppa4isra3dorthbk5454hem 12 31 is be VBZ work_rdyppa4isra3dorthbk5454hem 12 32 yet yet RB work_rdyppa4isra3dorthbk5454hem 12 33 unknown unknown JJ work_rdyppa4isra3dorthbk5454hem 12 34 . . . work_rdyppa4isra3dorthbk5454hem 13 1 In in IN work_rdyppa4isra3dorthbk5454hem 13 2 a a DT work_rdyppa4isra3dorthbk5454hem 13 3 family family NN work_rdyppa4isra3dorthbk5454hem 13 4 with with IN work_rdyppa4isra3dorthbk5454hem 13 5 a a DT work_rdyppa4isra3dorthbk5454hem 13 6 complex complex JJ work_rdyppa4isra3dorthbk5454hem 13 7 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 13 8 rearrangement rearrangement NN work_rdyppa4isra3dorthbk5454hem 13 9 , , , work_rdyppa4isra3dorthbk5454hem 13 10 the the DT work_rdyppa4isra3dorthbk5454hem 13 11 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 13 12 gene gene NN work_rdyppa4isra3dorthbk5454hem 13 13 was be VBD work_rdyppa4isra3dorthbk5454hem 13 14 truncated truncate VBN work_rdyppa4isra3dorthbk5454hem 13 15 by by IN work_rdyppa4isra3dorthbk5454hem 13 16 one one CD work_rdyppa4isra3dorthbk5454hem 13 17 of of IN work_rdyppa4isra3dorthbk5454hem 13 18 the the DT work_rdyppa4isra3dorthbk5454hem 13 19 breakpoints breakpoint NNS work_rdyppa4isra3dorthbk5454hem 13 20 in in IN work_rdyppa4isra3dorthbk5454hem 13 21 family family NN work_rdyppa4isra3dorthbk5454hem 13 22 members member NNS work_rdyppa4isra3dorthbk5454hem 13 23 with with IN work_rdyppa4isra3dorthbk5454hem 13 24 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 13 25 and and CC work_rdyppa4isra3dorthbk5454hem 13 26 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 13 27 was be VBD work_rdyppa4isra3dorthbk5454hem 13 28 therefore therefore RB work_rdyppa4isra3dorthbk5454hem 13 29 suggested suggest VBN work_rdyppa4isra3dorthbk5454hem 13 30 to to TO work_rdyppa4isra3dorthbk5454hem 13 31 be be VB work_rdyppa4isra3dorthbk5454hem 13 32 a a DT work_rdyppa4isra3dorthbk5454hem 13 33 candidate candidate NN work_rdyppa4isra3dorthbk5454hem 13 34 gene gene NN work_rdyppa4isra3dorthbk5454hem 13 35 for for IN work_rdyppa4isra3dorthbk5454hem 13 36 this this DT work_rdyppa4isra3dorthbk5454hem 13 37 disorder6 disorder6 NN work_rdyppa4isra3dorthbk5454hem 13 38 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 13 39 Figure Figure NNP work_rdyppa4isra3dorthbk5454hem 13 40 1a 1a NNP work_rdyppa4isra3dorthbk5454hem 13 41 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 13 42 . . . work_rdyppa4isra3dorthbk5454hem 14 1 In in IN work_rdyppa4isra3dorthbk5454hem 14 2 this this DT work_rdyppa4isra3dorthbk5454hem 14 3 study study NN work_rdyppa4isra3dorthbk5454hem 14 4 , , , work_rdyppa4isra3dorthbk5454hem 14 5 we -PRON- PRP work_rdyppa4isra3dorthbk5454hem 14 6 describe describe VBP work_rdyppa4isra3dorthbk5454hem 14 7 a a DT work_rdyppa4isra3dorthbk5454hem 14 8 three three CD work_rdyppa4isra3dorthbk5454hem 14 9 - - HYPH work_rdyppa4isra3dorthbk5454hem 14 10 generation generation NN work_rdyppa4isra3dorthbk5454hem 14 11 family family NN work_rdyppa4isra3dorthbk5454hem 14 12 with with IN work_rdyppa4isra3dorthbk5454hem 14 13 a a DT work_rdyppa4isra3dorthbk5454hem 14 14 balanced balanced JJ work_rdyppa4isra3dorthbk5454hem 14 15 t(7;15 t(7;15 NNS work_rdyppa4isra3dorthbk5454hem 14 16 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 14 17 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 14 18 . . . work_rdyppa4isra3dorthbk5454hem 15 1 The the DT work_rdyppa4isra3dorthbk5454hem 15 2 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 15 3 7q 7q CD work_rdyppa4isra3dorthbk5454hem 15 4 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 15 5 disrupts disrupt VBZ work_rdyppa4isra3dorthbk5454hem 15 6 the the DT work_rdyppa4isra3dorthbk5454hem 15 7 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 15 8 gene gene NN work_rdyppa4isra3dorthbk5454hem 15 9 , , , work_rdyppa4isra3dorthbk5454hem 15 10 but but CC work_rdyppa4isra3dorthbk5454hem 15 11 the the DT work_rdyppa4isra3dorthbk5454hem 15 12 transloca- transloca- JJ work_rdyppa4isra3dorthbk5454hem 15 13 tion tion NN work_rdyppa4isra3dorthbk5454hem 15 14 carriers carrier NNS work_rdyppa4isra3dorthbk5454hem 15 15 do do VBP work_rdyppa4isra3dorthbk5454hem 15 16 not not RB work_rdyppa4isra3dorthbk5454hem 15 17 present present VB work_rdyppa4isra3dorthbk5454hem 15 18 clinical clinical JJ work_rdyppa4isra3dorthbk5454hem 15 19 features feature NNS work_rdyppa4isra3dorthbk5454hem 15 20 of of IN work_rdyppa4isra3dorthbk5454hem 15 21 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 15 22 . . . work_rdyppa4isra3dorthbk5454hem 16 1 Materials material NNS work_rdyppa4isra3dorthbk5454hem 16 2 and and CC work_rdyppa4isra3dorthbk5454hem 16 3 methods method NNS work_rdyppa4isra3dorthbk5454hem 16 4 Cytogenetic cytogenetic JJ work_rdyppa4isra3dorthbk5454hem 16 5 analyses analysis NNS work_rdyppa4isra3dorthbk5454hem 16 6 , , , work_rdyppa4isra3dorthbk5454hem 16 7 FISH FISH NNS work_rdyppa4isra3dorthbk5454hem 16 8 and and CC work_rdyppa4isra3dorthbk5454hem 16 9 CGH CGH NNP work_rdyppa4isra3dorthbk5454hem 16 10 Metaphase Metaphase NNP work_rdyppa4isra3dorthbk5454hem 16 11 chromosomes chromosome NNS work_rdyppa4isra3dorthbk5454hem 16 12 were be VBD work_rdyppa4isra3dorthbk5454hem 16 13 obtained obtain VBN work_rdyppa4isra3dorthbk5454hem 16 14 from from IN work_rdyppa4isra3dorthbk5454hem 16 15 peripheral peripheral JJ work_rdyppa4isra3dorthbk5454hem 16 16 blood blood NN work_rdyppa4isra3dorthbk5454hem 16 17 lymphocytes lymphocyte NNS work_rdyppa4isra3dorthbk5454hem 16 18 and and CC work_rdyppa4isra3dorthbk5454hem 16 19 the the DT work_rdyppa4isra3dorthbk5454hem 16 20 karyotype karyotype NN work_rdyppa4isra3dorthbk5454hem 16 21 of of IN work_rdyppa4isra3dorthbk5454hem 16 22 the the DT work_rdyppa4isra3dorthbk5454hem 16 23 patient patient NN work_rdyppa4isra3dorthbk5454hem 16 24 was be VBD work_rdyppa4isra3dorthbk5454hem 16 25 determined determine VBN work_rdyppa4isra3dorthbk5454hem 16 26 by by IN work_rdyppa4isra3dorthbk5454hem 16 27 G g NN work_rdyppa4isra3dorthbk5454hem 16 28 - - HYPH work_rdyppa4isra3dorthbk5454hem 16 29 banding banding NN work_rdyppa4isra3dorthbk5454hem 16 30 . . . work_rdyppa4isra3dorthbk5454hem 17 1 Fluorescence fluorescence NN work_rdyppa4isra3dorthbk5454hem 17 2 in in IN work_rdyppa4isra3dorthbk5454hem 17 3 situ situ VBN work_rdyppa4isra3dorthbk5454hem 17 4 hybridiza- hybridiza- NN work_rdyppa4isra3dorthbk5454hem 17 5 tion tion NN work_rdyppa4isra3dorthbk5454hem 17 6 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 17 7 FISH fish NN work_rdyppa4isra3dorthbk5454hem 17 8 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 17 9 was be VBD work_rdyppa4isra3dorthbk5454hem 17 10 performed perform VBN work_rdyppa4isra3dorthbk5454hem 17 11 using use VBG work_rdyppa4isra3dorthbk5454hem 17 12 bacterial bacterial JJ work_rdyppa4isra3dorthbk5454hem 17 13 artificial artificial JJ work_rdyppa4isra3dorthbk5454hem 17 14 chro- chro- NN work_rdyppa4isra3dorthbk5454hem 17 15 mosome mosome NN work_rdyppa4isra3dorthbk5454hem 17 16 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 17 17 BAC BAC NNP work_rdyppa4isra3dorthbk5454hem 17 18 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 17 19 clones clone NNS work_rdyppa4isra3dorthbk5454hem 17 20 from from IN work_rdyppa4isra3dorthbk5454hem 17 21 the the DT work_rdyppa4isra3dorthbk5454hem 17 22 RPCI-11 RPCI-11 , work_rdyppa4isra3dorthbk5454hem 17 23 library library NN work_rdyppa4isra3dorthbk5454hem 17 24 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 17 25 Human Human NNP work_rdyppa4isra3dorthbk5454hem 17 26 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 17 27 Browser browser NN work_rdyppa4isra3dorthbk5454hem 17 28 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 17 29 according accord VBG work_rdyppa4isra3dorthbk5454hem 17 30 to to IN work_rdyppa4isra3dorthbk5454hem 17 31 standard standard JJ work_rdyppa4isra3dorthbk5454hem 17 32 procedures procedure NNS work_rdyppa4isra3dorthbk5454hem 17 33 . . . work_rdyppa4isra3dorthbk5454hem 18 1 High- High- NNP work_rdyppa4isra3dorthbk5454hem 18 2 resolution resolution NN work_rdyppa4isra3dorthbk5454hem 18 3 comparative comparative JJ work_rdyppa4isra3dorthbk5454hem 18 4 genome genome NN work_rdyppa4isra3dorthbk5454hem 18 5 - - HYPH work_rdyppa4isra3dorthbk5454hem 18 6 hybridization hybridization NN work_rdyppa4isra3dorthbk5454hem 18 7 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 18 8 CGH CGH NNP work_rdyppa4isra3dorthbk5454hem 18 9 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 18 10 was be VBD work_rdyppa4isra3dorthbk5454hem 18 11 carried carry VBN work_rdyppa4isra3dorthbk5454hem 18 12 out out RP work_rdyppa4isra3dorthbk5454hem 18 13 as as IN work_rdyppa4isra3dorthbk5454hem 18 14 described describe VBN work_rdyppa4isra3dorthbk5454hem 18 15 previously.10 previously.10 NNP work_rdyppa4isra3dorthbk5454hem 18 16 Results Results NNP work_rdyppa4isra3dorthbk5454hem 18 17 and and CC work_rdyppa4isra3dorthbk5454hem 18 18 discussion discussion NN work_rdyppa4isra3dorthbk5454hem 18 19 The the DT work_rdyppa4isra3dorthbk5454hem 18 20 family family NN work_rdyppa4isra3dorthbk5454hem 18 21 presented present VBN work_rdyppa4isra3dorthbk5454hem 18 22 in in IN work_rdyppa4isra3dorthbk5454hem 18 23 this this DT work_rdyppa4isra3dorthbk5454hem 18 24 study study NN work_rdyppa4isra3dorthbk5454hem 18 25 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 18 26 index index NN work_rdyppa4isra3dorthbk5454hem 18 27 case case NN work_rdyppa4isra3dorthbk5454hem 18 28 III;2 III;2 NNP work_rdyppa4isra3dorthbk5454hem 18 29 , , , work_rdyppa4isra3dorthbk5454hem 18 30 Figure Figure NNP work_rdyppa4isra3dorthbk5454hem 18 31 1b 1b NN work_rdyppa4isra3dorthbk5454hem 18 32 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 18 33 was be VBD work_rdyppa4isra3dorthbk5454hem 18 34 detected detect VBN work_rdyppa4isra3dorthbk5454hem 18 35 through through IN work_rdyppa4isra3dorthbk5454hem 18 36 a a DT work_rdyppa4isra3dorthbk5454hem 18 37 systematic systematic JJ work_rdyppa4isra3dorthbk5454hem 18 38 re re NN work_rdyppa4isra3dorthbk5454hem 18 39 - - VBG work_rdyppa4isra3dorthbk5454hem 18 40 examina- examina- JJ work_rdyppa4isra3dorthbk5454hem 18 41 tion tion NN work_rdyppa4isra3dorthbk5454hem 18 42 of of IN work_rdyppa4isra3dorthbk5454hem 18 43 balanced balanced JJ work_rdyppa4isra3dorthbk5454hem 18 44 reciprocal reciprocal JJ work_rdyppa4isra3dorthbk5454hem 18 45 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 18 46 carriers carrier NNS work_rdyppa4isra3dorthbk5454hem 18 47 in in IN work_rdyppa4isra3dorthbk5454hem 18 48 Den- Den- NNP work_rdyppa4isra3dorthbk5454hem 18 49 mark.11 mark.11 NNP work_rdyppa4isra3dorthbk5454hem 18 50 The the DT work_rdyppa4isra3dorthbk5454hem 18 51 family family NN work_rdyppa4isra3dorthbk5454hem 18 52 history history NN work_rdyppa4isra3dorthbk5454hem 18 53 revealed reveal VBD work_rdyppa4isra3dorthbk5454hem 18 54 that that IN work_rdyppa4isra3dorthbk5454hem 18 55 the the DT work_rdyppa4isra3dorthbk5454hem 18 56 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 18 57 in in IN work_rdyppa4isra3dorthbk5454hem 18 58 the the DT work_rdyppa4isra3dorthbk5454hem 18 59 family family NN work_rdyppa4isra3dorthbk5454hem 18 60 was be VBD work_rdyppa4isra3dorthbk5454hem 18 61 first first RB work_rdyppa4isra3dorthbk5454hem 18 62 recognized recognize VBN work_rdyppa4isra3dorthbk5454hem 18 63 after after IN work_rdyppa4isra3dorthbk5454hem 18 64 the the DT work_rdyppa4isra3dorthbk5454hem 18 65 birth birth NN work_rdyppa4isra3dorthbk5454hem 18 66 of of IN work_rdyppa4isra3dorthbk5454hem 18 67 a a DT work_rdyppa4isra3dorthbk5454hem 18 68 boy boy NN work_rdyppa4isra3dorthbk5454hem 18 69 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 18 70 V;1 V;1 NNP work_rdyppa4isra3dorthbk5454hem 18 71 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 18 72 with with IN work_rdyppa4isra3dorthbk5454hem 18 73 multiple multiple JJ work_rdyppa4isra3dorthbk5454hem 18 74 congenital congenital JJ work_rdyppa4isra3dorthbk5454hem 18 75 malformations malformation NNS work_rdyppa4isra3dorthbk5454hem 18 76 and and CC work_rdyppa4isra3dorthbk5454hem 18 77 an an DT work_rdyppa4isra3dorthbk5454hem 18 78 unbalanced unbalanced JJ work_rdyppa4isra3dorthbk5454hem 18 79 karyotype karyotype NN work_rdyppa4isra3dorthbk5454hem 18 80 , , , work_rdyppa4isra3dorthbk5454hem 18 81 46,XY 46,xy CD work_rdyppa4isra3dorthbk5454hem 18 82 , , , work_rdyppa4isra3dorthbk5454hem 18 83 der(7)t(7;15)(q35;q26.2 der(7)t(7;15)(q35;q26.2 NNP work_rdyppa4isra3dorthbk5454hem 18 84 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 18 85 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 18 86 Figure figure NN work_rdyppa4isra3dorthbk5454hem 18 87 1b 1b NN work_rdyppa4isra3dorthbk5454hem 18 88 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 18 89 . . . work_rdyppa4isra3dorthbk5454hem 19 1 Cytogenetic cytogenetic JJ work_rdyppa4isra3dorthbk5454hem 19 2 analyses analysis NNS work_rdyppa4isra3dorthbk5454hem 19 3 showed show VBD work_rdyppa4isra3dorthbk5454hem 19 4 that that IN work_rdyppa4isra3dorthbk5454hem 19 5 his -PRON- PRP$ work_rdyppa4isra3dorthbk5454hem 19 6 father father NN work_rdyppa4isra3dorthbk5454hem 19 7 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 19 8 IV;2 IV;2 NNP work_rdyppa4isra3dorthbk5454hem 19 9 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 19 10 , , , work_rdyppa4isra3dorthbk5454hem 19 11 grandmother grandmother NN work_rdyppa4isra3dorthbk5454hem 19 12 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 19 13 III;2 III;2 NNP work_rdyppa4isra3dorthbk5454hem 19 14 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 19 15 and and CC work_rdyppa4isra3dorthbk5454hem 19 16 great great JJ work_rdyppa4isra3dorthbk5454hem 19 17 grandfather grandfather NN work_rdyppa4isra3dorthbk5454hem 19 18 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 19 19 II;1 ii;1 NN work_rdyppa4isra3dorthbk5454hem 19 20 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 19 21 were be VBD work_rdyppa4isra3dorthbk5454hem 19 22 all all DT work_rdyppa4isra3dorthbk5454hem 19 23 carriers carrier NNS work_rdyppa4isra3dorthbk5454hem 19 24 of of IN work_rdyppa4isra3dorthbk5454hem 19 25 an an DT work_rdyppa4isra3dorthbk5454hem 19 26 apparently apparently RB work_rdyppa4isra3dorthbk5454hem 19 27 balanced balanced JJ work_rdyppa4isra3dorthbk5454hem 19 28 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 19 29 with with IN work_rdyppa4isra3dorthbk5454hem 19 30 the the DT work_rdyppa4isra3dorthbk5454hem 19 31 karyotype karyotype NNP work_rdyppa4isra3dorthbk5454hem 19 32 46,XX 46,xx NN work_rdyppa4isra3dorthbk5454hem 19 33 / / SYM work_rdyppa4isra3dorthbk5454hem 19 34 XY XY NNP work_rdyppa4isra3dorthbk5454hem 19 35 , , , work_rdyppa4isra3dorthbk5454hem 19 36 t(7;15)(q35;q26.2 t(7;15)(q35;q26.2 NNP work_rdyppa4isra3dorthbk5454hem 19 37 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 19 38 . . . work_rdyppa4isra3dorthbk5454hem 20 1 Subsequently subsequently RB work_rdyppa4isra3dorthbk5454hem 20 2 IV;4 iv;4 NN work_rdyppa4isra3dorthbk5454hem 20 3 was be VBD work_rdyppa4isra3dorthbk5454hem 20 4 investigated investigate VBN work_rdyppa4isra3dorthbk5454hem 20 5 and and CC work_rdyppa4isra3dorthbk5454hem 20 6 she -PRON- PRP work_rdyppa4isra3dorthbk5454hem 20 7 was be VBD work_rdyppa4isra3dorthbk5454hem 20 8 shown show VBN work_rdyppa4isra3dorthbk5454hem 20 9 to to TO work_rdyppa4isra3dorthbk5454hem 20 10 be be VB work_rdyppa4isra3dorthbk5454hem 20 11 carrier carrier NN work_rdyppa4isra3dorthbk5454hem 20 12 of of IN work_rdyppa4isra3dorthbk5454hem 20 13 the the DT work_rdyppa4isra3dorthbk5454hem 20 14 same same JJ work_rdyppa4isra3dorthbk5454hem 20 15 unbalanced unbalanced JJ work_rdyppa4isra3dorthbk5454hem 20 16 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 20 17 as as IN work_rdyppa4isra3dorthbk5454hem 20 18 found find VBN work_rdyppa4isra3dorthbk5454hem 20 19 in in IN work_rdyppa4isra3dorthbk5454hem 20 20 V;1 V;1 NNP work_rdyppa4isra3dorthbk5454hem 20 21 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 20 22 Figure Figure NNP work_rdyppa4isra3dorthbk5454hem 20 23 1b 1b NNP work_rdyppa4isra3dorthbk5454hem 20 24 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 20 25 . . . work_rdyppa4isra3dorthbk5454hem 21 1 IV;4 IV;4 NNP work_rdyppa4isra3dorthbk5454hem 21 2 had have VBD work_rdyppa4isra3dorthbk5454hem 21 3 multiple multiple JJ work_rdyppa4isra3dorthbk5454hem 21 4 malformations malformation NNS work_rdyppa4isra3dorthbk5454hem 21 5 , , , work_rdyppa4isra3dorthbk5454hem 21 6 severe severe JJ work_rdyppa4isra3dorthbk5454hem 21 7 mental mental JJ work_rdyppa4isra3dorthbk5454hem 21 8 retardation retardation NN work_rdyppa4isra3dorthbk5454hem 21 9 and and CC work_rdyppa4isra3dorthbk5454hem 21 10 did do VBD work_rdyppa4isra3dorthbk5454hem 21 11 not not RB work_rdyppa4isra3dorthbk5454hem 21 12 have have VB work_rdyppa4isra3dorthbk5454hem 21 13 any any DT work_rdyppa4isra3dorthbk5454hem 21 14 language language NN work_rdyppa4isra3dorthbk5454hem 21 15 development development NN work_rdyppa4isra3dorthbk5454hem 21 16 . . . work_rdyppa4isra3dorthbk5454hem 22 1 She -PRON- PRP work_rdyppa4isra3dorthbk5454hem 22 2 had have VBD work_rdyppa4isra3dorthbk5454hem 22 3 scoliosis scoliosis NN work_rdyppa4isra3dorthbk5454hem 22 4 and and CC work_rdyppa4isra3dorthbk5454hem 22 5 could could MD work_rdyppa4isra3dorthbk5454hem 22 6 take take VB work_rdyppa4isra3dorthbk5454hem 22 7 only only RB work_rdyppa4isra3dorthbk5454hem 22 8 a a DT work_rdyppa4isra3dorthbk5454hem 22 9 few few JJ work_rdyppa4isra3dorthbk5454hem 22 10 steps step NNS work_rdyppa4isra3dorthbk5454hem 22 11 with with IN work_rdyppa4isra3dorthbk5454hem 22 12 support support NN work_rdyppa4isra3dorthbk5454hem 22 13 , , , work_rdyppa4isra3dorthbk5454hem 22 14 but but CC work_rdyppa4isra3dorthbk5454hem 22 15 otherwise otherwise RB work_rdyppa4isra3dorthbk5454hem 22 16 could could MD work_rdyppa4isra3dorthbk5454hem 22 17 not not RB work_rdyppa4isra3dorthbk5454hem 22 18 walk walk VB work_rdyppa4isra3dorthbk5454hem 22 19 . . . work_rdyppa4isra3dorthbk5454hem 23 1 She -PRON- PRP work_rdyppa4isra3dorthbk5454hem 23 2 had have VBD work_rdyppa4isra3dorthbk5454hem 23 3 a a DT work_rdyppa4isra3dorthbk5454hem 23 4 single single JJ work_rdyppa4isra3dorthbk5454hem 23 5 kidney kidney NN work_rdyppa4isra3dorthbk5454hem 23 6 , , , work_rdyppa4isra3dorthbk5454hem 23 7 hearing hearing NN work_rdyppa4isra3dorthbk5454hem 23 8 loss loss NN work_rdyppa4isra3dorthbk5454hem 23 9 , , , work_rdyppa4isra3dorthbk5454hem 23 10 ptosis ptosis NN work_rdyppa4isra3dorthbk5454hem 23 11 and and CC work_rdyppa4isra3dorthbk5454hem 23 12 vision vision NN work_rdyppa4isra3dorthbk5454hem 23 13 loss loss NN work_rdyppa4isra3dorthbk5454hem 23 14 because because IN work_rdyppa4isra3dorthbk5454hem 23 15 of of IN work_rdyppa4isra3dorthbk5454hem 23 16 cataract cataract NN work_rdyppa4isra3dorthbk5454hem 23 17 and and CC work_rdyppa4isra3dorthbk5454hem 23 18 affected affect VBN work_rdyppa4isra3dorthbk5454hem 23 19 optic optic JJ work_rdyppa4isra3dorthbk5454hem 23 20 nerve nerve NN work_rdyppa4isra3dorthbk5454hem 23 21 . . . work_rdyppa4isra3dorthbk5454hem 24 1 She -PRON- PRP work_rdyppa4isra3dorthbk5454hem 24 2 did do VBD work_rdyppa4isra3dorthbk5454hem 24 3 not not RB work_rdyppa4isra3dorthbk5454hem 24 4 have have VB work_rdyppa4isra3dorthbk5454hem 24 5 any any DT work_rdyppa4isra3dorthbk5454hem 24 6 sense sense NN work_rdyppa4isra3dorthbk5454hem 24 7 of of IN work_rdyppa4isra3dorthbk5454hem 24 8 hunger hunger NN work_rdyppa4isra3dorthbk5454hem 24 9 and and CC work_rdyppa4isra3dorthbk5454hem 24 10 therefore therefore RB work_rdyppa4isra3dorthbk5454hem 24 11 she -PRON- PRP work_rdyppa4isra3dorthbk5454hem 24 12 was be VBD work_rdyppa4isra3dorthbk5454hem 24 13 fed feed VBN work_rdyppa4isra3dorthbk5454hem 24 14 through through IN work_rdyppa4isra3dorthbk5454hem 24 15 a a DT work_rdyppa4isra3dorthbk5454hem 24 16 tube tube NN work_rdyppa4isra3dorthbk5454hem 24 17 . . . work_rdyppa4isra3dorthbk5454hem 25 1 She -PRON- PRP work_rdyppa4isra3dorthbk5454hem 25 2 had have VBD work_rdyppa4isra3dorthbk5454hem 25 3 a a DT work_rdyppa4isra3dorthbk5454hem 25 4 cheerful cheerful JJ work_rdyppa4isra3dorthbk5454hem 25 5 and and CC work_rdyppa4isra3dorthbk5454hem 25 6 extrovert extrovert JJ work_rdyppa4isra3dorthbk5454hem 25 7 personality personality NN work_rdyppa4isra3dorthbk5454hem 25 8 . . . work_rdyppa4isra3dorthbk5454hem 26 1 She -PRON- PRP work_rdyppa4isra3dorthbk5454hem 26 2 died die VBD work_rdyppa4isra3dorthbk5454hem 26 3 at at IN work_rdyppa4isra3dorthbk5454hem 26 4 the the DT work_rdyppa4isra3dorthbk5454hem 26 5 age age NN work_rdyppa4isra3dorthbk5454hem 26 6 of of IN work_rdyppa4isra3dorthbk5454hem 26 7 34 34 CD work_rdyppa4isra3dorthbk5454hem 26 8 years year NNS work_rdyppa4isra3dorthbk5454hem 26 9 . . . work_rdyppa4isra3dorthbk5454hem 27 1 The the DT work_rdyppa4isra3dorthbk5454hem 27 2 other other JJ work_rdyppa4isra3dorthbk5454hem 27 3 patient patient NN work_rdyppa4isra3dorthbk5454hem 27 4 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 27 5 V;1 V;1 NNP work_rdyppa4isra3dorthbk5454hem 27 6 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 27 7 with with IN work_rdyppa4isra3dorthbk5454hem 27 8 the the DT work_rdyppa4isra3dorthbk5454hem 27 9 same same JJ work_rdyppa4isra3dorthbk5454hem 27 10 unbalanced unbalanced JJ work_rdyppa4isra3dorthbk5454hem 27 11 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 27 12 is be VBZ work_rdyppa4isra3dorthbk5454hem 27 13 presently presently RB work_rdyppa4isra3dorthbk5454hem 27 14 16 16 CD work_rdyppa4isra3dorthbk5454hem 27 15 years year NNS work_rdyppa4isra3dorthbk5454hem 27 16 old old JJ work_rdyppa4isra3dorthbk5454hem 27 17 ; ; : work_rdyppa4isra3dorthbk5454hem 27 18 he -PRON- PRP work_rdyppa4isra3dorthbk5454hem 27 19 also also RB work_rdyppa4isra3dorthbk5454hem 27 20 has have VBZ work_rdyppa4isra3dorthbk5454hem 27 21 multiple multiple JJ work_rdyppa4isra3dorthbk5454hem 27 22 congenital congenital JJ work_rdyppa4isra3dorthbk5454hem 27 23 malformations malformation NNS work_rdyppa4isra3dorthbk5454hem 27 24 , , , work_rdyppa4isra3dorthbk5454hem 27 25 severe severe JJ work_rdyppa4isra3dorthbk5454hem 27 26 mental mental JJ work_rdyppa4isra3dorthbk5454hem 27 27 retardation retardation NN work_rdyppa4isra3dorthbk5454hem 27 28 , , , work_rdyppa4isra3dorthbk5454hem 27 29 no no DT work_rdyppa4isra3dorthbk5454hem 27 30 language language NN work_rdyppa4isra3dorthbk5454hem 27 31 development development NN work_rdyppa4isra3dorthbk5454hem 27 32 and and CC work_rdyppa4isra3dorthbk5454hem 27 33 scoliosis scoliosis NN work_rdyppa4isra3dorthbk5454hem 27 34 . . . work_rdyppa4isra3dorthbk5454hem 28 1 How- How- NNP work_rdyppa4isra3dorthbk5454hem 28 2 ever ever RB work_rdyppa4isra3dorthbk5454hem 28 3 , , , work_rdyppa4isra3dorthbk5454hem 28 4 he -PRON- PRP work_rdyppa4isra3dorthbk5454hem 28 5 can can MD work_rdyppa4isra3dorthbk5454hem 28 6 not not RB work_rdyppa4isra3dorthbk5454hem 28 7 walk walk VB work_rdyppa4isra3dorthbk5454hem 28 8 even even RB work_rdyppa4isra3dorthbk5454hem 28 9 with with IN work_rdyppa4isra3dorthbk5454hem 28 10 support support NN work_rdyppa4isra3dorthbk5454hem 28 11 . . . work_rdyppa4isra3dorthbk5454hem 29 1 He -PRON- PRP work_rdyppa4isra3dorthbk5454hem 29 2 has have VBZ work_rdyppa4isra3dorthbk5454hem 29 3 myopia myopia NN work_rdyppa4isra3dorthbk5454hem 29 4 , , , work_rdyppa4isra3dorthbk5454hem 29 5 otherwise otherwise RB work_rdyppa4isra3dorthbk5454hem 29 6 his -PRON- PRP$ work_rdyppa4isra3dorthbk5454hem 29 7 vision vision NN work_rdyppa4isra3dorthbk5454hem 29 8 is be VBZ work_rdyppa4isra3dorthbk5454hem 29 9 normal normal JJ work_rdyppa4isra3dorthbk5454hem 29 10 . . . work_rdyppa4isra3dorthbk5454hem 30 1 He -PRON- PRP work_rdyppa4isra3dorthbk5454hem 30 2 has have VBZ work_rdyppa4isra3dorthbk5454hem 30 3 an an DT work_rdyppa4isra3dorthbk5454hem 30 4 introverted introverted JJ work_rdyppa4isra3dorthbk5454hem 30 5 personality personality NN work_rdyppa4isra3dorthbk5454hem 30 6 . . . work_rdyppa4isra3dorthbk5454hem 31 1 The the DT work_rdyppa4isra3dorthbk5454hem 31 2 index index NN work_rdyppa4isra3dorthbk5454hem 31 3 case case NN work_rdyppa4isra3dorthbk5454hem 31 4 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 31 5 III;2 III;2 NNP work_rdyppa4isra3dorthbk5454hem 31 6 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 31 7 had have VBD work_rdyppa4isra3dorthbk5454hem 31 8 hypermetropia hypermetropia NN work_rdyppa4isra3dorthbk5454hem 31 9 and and CC work_rdyppa4isra3dorthbk5454hem 31 10 she -PRON- PRP work_rdyppa4isra3dorthbk5454hem 31 11 developed develop VBD work_rdyppa4isra3dorthbk5454hem 31 12 pre pre JJ work_rdyppa4isra3dorthbk5454hem 31 13 - - NN work_rdyppa4isra3dorthbk5454hem 31 14 eclampsia eclampsia NN work_rdyppa4isra3dorthbk5454hem 31 15 during during IN work_rdyppa4isra3dorthbk5454hem 31 16 her -PRON- PRP$ work_rdyppa4isra3dorthbk5454hem 31 17 second second JJ work_rdyppa4isra3dorthbk5454hem 31 18 gestation gestation NN work_rdyppa4isra3dorthbk5454hem 31 19 . . . work_rdyppa4isra3dorthbk5454hem 32 1 All all PDT work_rdyppa4isra3dorthbk5454hem 32 2 the the DT work_rdyppa4isra3dorthbk5454hem 32 3 balanced balanced JJ work_rdyppa4isra3dorthbk5454hem 32 4 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 32 5 carriers carrier NNS work_rdyppa4isra3dorthbk5454hem 32 6 were be VBD work_rdyppa4isra3dorthbk5454hem 32 7 otherwise otherwise RB work_rdyppa4isra3dorthbk5454hem 32 8 phenotypically phenotypically RB work_rdyppa4isra3dorthbk5454hem 32 9 normal normal JJ work_rdyppa4isra3dorthbk5454hem 32 10 . . . work_rdyppa4isra3dorthbk5454hem 33 1 None none NN work_rdyppa4isra3dorthbk5454hem 33 2 of of IN work_rdyppa4isra3dorthbk5454hem 33 3 the the DT work_rdyppa4isra3dorthbk5454hem 33 4 balanced balanced JJ work_rdyppa4isra3dorthbk5454hem 33 5 transloca- transloca- JJ work_rdyppa4isra3dorthbk5454hem 33 6 tion tion NN work_rdyppa4isra3dorthbk5454hem 33 7 carriers carrier NNS work_rdyppa4isra3dorthbk5454hem 33 8 showed show VBD work_rdyppa4isra3dorthbk5454hem 33 9 any any DT work_rdyppa4isra3dorthbk5454hem 33 10 signs sign NNS work_rdyppa4isra3dorthbk5454hem 33 11 of of IN work_rdyppa4isra3dorthbk5454hem 33 12 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 33 13 , , , work_rdyppa4isra3dorthbk5454hem 33 14 assessed assess VBD work_rdyppa4isra3dorthbk5454hem 33 15 according accord VBG work_rdyppa4isra3dorthbk5454hem 33 16 to to IN work_rdyppa4isra3dorthbk5454hem 33 17 the the DT work_rdyppa4isra3dorthbk5454hem 33 18 DSM DSM NNP work_rdyppa4isra3dorthbk5454hem 33 19 - - HYPH work_rdyppa4isra3dorthbk5454hem 33 20 IV IV NNP work_rdyppa4isra3dorthbk5454hem 33 21 diagnostic diagnostic JJ work_rdyppa4isra3dorthbk5454hem 33 22 criteria criterion NNS work_rdyppa4isra3dorthbk5454hem 33 23 . . . work_rdyppa4isra3dorthbk5454hem 34 1 FISH FISH NNS work_rdyppa4isra3dorthbk5454hem 34 2 analyses analysis NNS work_rdyppa4isra3dorthbk5454hem 34 3 of of IN work_rdyppa4isra3dorthbk5454hem 34 4 the the DT work_rdyppa4isra3dorthbk5454hem 34 5 balanced balanced JJ work_rdyppa4isra3dorthbk5454hem 34 6 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 34 7 carrier carrier NN work_rdyppa4isra3dorthbk5454hem 34 8 III;2 iii;2 NN work_rdyppa4isra3dorthbk5454hem 34 9 using use VBG work_rdyppa4isra3dorthbk5454hem 34 10 BAC BAC NNP work_rdyppa4isra3dorthbk5454hem 34 11 clones clone NNS work_rdyppa4isra3dorthbk5454hem 34 12 from from IN work_rdyppa4isra3dorthbk5454hem 34 13 the the DT work_rdyppa4isra3dorthbk5454hem 34 14 RPCI-11 RPCI-11 , work_rdyppa4isra3dorthbk5454hem 34 15 library library NN work_rdyppa4isra3dorthbk5454hem 34 16 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 34 17 Human Human NNP work_rdyppa4isra3dorthbk5454hem 34 18 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 34 19 Browser Browser NNP work_rdyppa4isra3dorthbk5454hem 34 20 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 34 21 revealed reveal VBD work_rdyppa4isra3dorthbk5454hem 34 22 that that IN work_rdyppa4isra3dorthbk5454hem 34 23 the the DT work_rdyppa4isra3dorthbk5454hem 34 24 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 34 25 7q 7q CD work_rdyppa4isra3dorthbk5454hem 34 26 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 34 27 was be VBD work_rdyppa4isra3dorthbk5454hem 34 28 within within IN work_rdyppa4isra3dorthbk5454hem 34 29 the the DT work_rdyppa4isra3dorthbk5454hem 34 30 BAC BAC NNP work_rdyppa4isra3dorthbk5454hem 34 31 clone clone NN work_rdyppa4isra3dorthbk5454hem 34 32 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 34 33 - - HYPH work_rdyppa4isra3dorthbk5454hem 34 34 162a9 162a9 NNP work_rdyppa4isra3dorthbk5454hem 34 35 , , , work_rdyppa4isra3dorthbk5454hem 34 36 which which WDT work_rdyppa4isra3dorthbk5454hem 34 37 is be VBZ work_rdyppa4isra3dorthbk5454hem 34 38 located locate VBN work_rdyppa4isra3dorthbk5454hem 34 39 entirely entirely RB work_rdyppa4isra3dorthbk5454hem 34 40 within within IN work_rdyppa4isra3dorthbk5454hem 34 41 the the DT work_rdyppa4isra3dorthbk5454hem 34 42 genomic genomic JJ work_rdyppa4isra3dorthbk5454hem 34 43 region region NN work_rdyppa4isra3dorthbk5454hem 34 44 covered cover VBN work_rdyppa4isra3dorthbk5454hem 34 45 by by IN work_rdyppa4isra3dorthbk5454hem 34 46 the the DT work_rdyppa4isra3dorthbk5454hem 34 47 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 34 48 gene gene NN work_rdyppa4isra3dorthbk5454hem 34 49 . . . work_rdyppa4isra3dorthbk5454hem 35 1 The the DT work_rdyppa4isra3dorthbk5454hem 35 2 closest close JJS work_rdyppa4isra3dorthbk5454hem 35 3 non non JJ work_rdyppa4isra3dorthbk5454hem 35 4 - - JJ work_rdyppa4isra3dorthbk5454hem 35 5 spanning span VBG work_rdyppa4isra3dorthbk5454hem 35 6 proximal proximal JJ work_rdyppa4isra3dorthbk5454hem 35 7 BAC BAC NNP work_rdyppa4isra3dorthbk5454hem 35 8 clones clone NNS work_rdyppa4isra3dorthbk5454hem 35 9 were be VBD work_rdyppa4isra3dorthbk5454hem 35 10 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 35 11 - - HYPH work_rdyppa4isra3dorthbk5454hem 35 12 945o17 945o17 NNP work_rdyppa4isra3dorthbk5454hem 35 13 and and CC work_rdyppa4isra3dorthbk5454hem 35 14 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 35 15 - - HYPH work_rdyppa4isra3dorthbk5454hem 35 16 291n9 291n9 NNP work_rdyppa4isra3dorthbk5454hem 35 17 , , , work_rdyppa4isra3dorthbk5454hem 35 18 and and CC work_rdyppa4isra3dorthbk5454hem 35 19 the the DT work_rdyppa4isra3dorthbk5454hem 35 20 closest close JJS work_rdyppa4isra3dorthbk5454hem 35 21 non non JJ work_rdyppa4isra3dorthbk5454hem 35 22 - - JJ work_rdyppa4isra3dorthbk5454hem 35 23 spanning spanning JJ work_rdyppa4isra3dorthbk5454hem 35 24 distal distal JJ work_rdyppa4isra3dorthbk5454hem 35 25 BAC BAC NNP work_rdyppa4isra3dorthbk5454hem 35 26 clones clone NNS work_rdyppa4isra3dorthbk5454hem 35 27 were be VBD work_rdyppa4isra3dorthbk5454hem 35 28 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 35 29 - - HYPH work_rdyppa4isra3dorthbk5454hem 35 30 688o16 688o16 NNP work_rdyppa4isra3dorthbk5454hem 35 31 and and CC work_rdyppa4isra3dorthbk5454hem 35 32 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 35 33 - - HYPH work_rdyppa4isra3dorthbk5454hem 35 34 641c20 641c20 NNP work_rdyppa4isra3dorthbk5454hem 35 35 . . . work_rdyppa4isra3dorthbk5454hem 36 1 The the DT work_rdyppa4isra3dorthbk5454hem 36 2 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 36 3 was be VBD work_rdyppa4isra3dorthbk5454hem 36 4 thus thus RB work_rdyppa4isra3dorthbk5454hem 36 5 localized localize VBN work_rdyppa4isra3dorthbk5454hem 36 6 to to IN work_rdyppa4isra3dorthbk5454hem 36 7 a a DT work_rdyppa4isra3dorthbk5454hem 36 8 region region NN work_rdyppa4isra3dorthbk5454hem 36 9 of of IN work_rdyppa4isra3dorthbk5454hem 36 10 approximately approximately RB work_rdyppa4isra3dorthbk5454hem 36 11 21-kb 21-kb CD work_rdyppa4isra3dorthbk5454hem 36 12 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 36 13 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 36 14 position position NN work_rdyppa4isra3dorthbk5454hem 36 15 , , , work_rdyppa4isra3dorthbk5454hem 36 16 146.839.903–146.861.494 146.839.903–146.861.494 CD work_rdyppa4isra3dorthbk5454hem 36 17 . . . work_rdyppa4isra3dorthbk5454hem 37 1 Human human JJ work_rdyppa4isra3dorthbk5454hem 37 2 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 37 3 Browser Browser NNP work_rdyppa4isra3dorthbk5454hem 37 4 , , , work_rdyppa4isra3dorthbk5454hem 37 5 March March NNP work_rdyppa4isra3dorthbk5454hem 37 6 2006 2006 CD work_rdyppa4isra3dorthbk5454hem 37 7 Assembly Assembly NNP work_rdyppa4isra3dorthbk5454hem 37 8 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 37 9 within within IN work_rdyppa4isra3dorthbk5454hem 37 10 intron intron NNP work_rdyppa4isra3dorthbk5454hem 37 11 11 11 CD work_rdyppa4isra3dorthbk5454hem 37 12 of of IN work_rdyppa4isra3dorthbk5454hem 37 13 the the DT work_rdyppa4isra3dorthbk5454hem 37 14 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 37 15 gene gene NN work_rdyppa4isra3dorthbk5454hem 37 16 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 37 17 Figure Figure NNP work_rdyppa4isra3dorthbk5454hem 37 18 1a 1a NNP work_rdyppa4isra3dorthbk5454hem 37 19 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 37 20 . . . work_rdyppa4isra3dorthbk5454hem 38 1 The the DT work_rdyppa4isra3dorthbk5454hem 38 2 15q26.1 15q26.1 CD work_rdyppa4isra3dorthbk5454hem 38 3 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 38 4 was be VBD work_rdyppa4isra3dorthbk5454hem 38 5 within within IN work_rdyppa4isra3dorthbk5454hem 38 6 the the DT work_rdyppa4isra3dorthbk5454hem 38 7 overlapping overlap VBG work_rdyppa4isra3dorthbk5454hem 38 8 region region NN work_rdyppa4isra3dorthbk5454hem 38 9 of of IN work_rdyppa4isra3dorthbk5454hem 38 10 three three CD work_rdyppa4isra3dorthbk5454hem 38 11 BAC BAC NNP work_rdyppa4isra3dorthbk5454hem 38 12 clones clone NNS work_rdyppa4isra3dorthbk5454hem 38 13 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 38 14 - - HYPH work_rdyppa4isra3dorthbk5454hem 38 15 231p17 231p17 NNP work_rdyppa4isra3dorthbk5454hem 38 16 , , , work_rdyppa4isra3dorthbk5454hem 38 17 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 38 18 - - HYPH work_rdyppa4isra3dorthbk5454hem 38 19 78b3 78b3 NNP work_rdyppa4isra3dorthbk5454hem 38 20 , , , work_rdyppa4isra3dorthbk5454hem 38 21 and and CC work_rdyppa4isra3dorthbk5454hem 38 22 RP11 RP11 NNP work_rdyppa4isra3dorthbk5454hem 38 23 - - HYPH work_rdyppa4isra3dorthbk5454hem 38 24 296i21 296i21 NNP work_rdyppa4isra3dorthbk5454hem 38 25 . . . work_rdyppa4isra3dorthbk5454hem 39 1 This this DT work_rdyppa4isra3dorthbk5454hem 39 2 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 39 3 was be VBD work_rdyppa4isra3dorthbk5454hem 39 4 localized localize VBN work_rdyppa4isra3dorthbk5454hem 39 5 to to IN work_rdyppa4isra3dorthbk5454hem 39 6 an an DT work_rdyppa4isra3dorthbk5454hem 39 7 Figure figure NN work_rdyppa4isra3dorthbk5454hem 39 8 1 1 CD work_rdyppa4isra3dorthbk5454hem 39 9 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 39 10 a a DT work_rdyppa4isra3dorthbk5454hem 39 11 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 39 12 Schematic schematic JJ work_rdyppa4isra3dorthbk5454hem 39 13 representation representation NN work_rdyppa4isra3dorthbk5454hem 39 14 of of IN work_rdyppa4isra3dorthbk5454hem 39 15 the the DT work_rdyppa4isra3dorthbk5454hem 39 16 two two CD work_rdyppa4isra3dorthbk5454hem 39 17 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 39 18 breakpoints breakpoint NNS work_rdyppa4isra3dorthbk5454hem 39 19 truncating truncate VBG work_rdyppa4isra3dorthbk5454hem 39 20 the the DT work_rdyppa4isra3dorthbk5454hem 39 21 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 39 22 gene gene NN work_rdyppa4isra3dorthbk5454hem 39 23 . . . work_rdyppa4isra3dorthbk5454hem 40 1 The the DT work_rdyppa4isra3dorthbk5454hem 40 2 white white JJ work_rdyppa4isra3dorthbk5454hem 40 3 bar bar NN work_rdyppa4isra3dorthbk5454hem 40 4 indicates indicate VBZ work_rdyppa4isra3dorthbk5454hem 40 5 the the DT work_rdyppa4isra3dorthbk5454hem 40 6 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 40 7 region region NN work_rdyppa4isra3dorthbk5454hem 40 8 described describe VBN work_rdyppa4isra3dorthbk5454hem 40 9 by by IN work_rdyppa4isra3dorthbk5454hem 40 10 Verkerk Verkerk NNP work_rdyppa4isra3dorthbk5454hem 40 11 and and CC work_rdyppa4isra3dorthbk5454hem 40 12 colleagues6 colleagues6 NN work_rdyppa4isra3dorthbk5454hem 40 13 in in IN work_rdyppa4isra3dorthbk5454hem 40 14 a a DT work_rdyppa4isra3dorthbk5454hem 40 15 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 40 16 patient patient NN work_rdyppa4isra3dorthbk5454hem 40 17 with with IN work_rdyppa4isra3dorthbk5454hem 40 18 inv(2)(p23q22),ins(7;2)(q35-q36;p21p23 inv(2)(p23q22),ins(7;2)(q35-q36;p21p23 NN work_rdyppa4isra3dorthbk5454hem 40 19 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 40 20 and and CC work_rdyppa4isra3dorthbk5454hem 40 21 the the DT work_rdyppa4isra3dorthbk5454hem 40 22 black black JJ work_rdyppa4isra3dorthbk5454hem 40 23 bar bar NN work_rdyppa4isra3dorthbk5454hem 40 24 indicates indicate VBZ work_rdyppa4isra3dorthbk5454hem 40 25 the the DT work_rdyppa4isra3dorthbk5454hem 40 26 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 40 27 region region NN work_rdyppa4isra3dorthbk5454hem 40 28 of of IN work_rdyppa4isra3dorthbk5454hem 40 29 the the DT work_rdyppa4isra3dorthbk5454hem 40 30 present present JJ work_rdyppa4isra3dorthbk5454hem 40 31 case case NN work_rdyppa4isra3dorthbk5454hem 40 32 with with IN work_rdyppa4isra3dorthbk5454hem 40 33 t(7;15 t(7;15 NNS work_rdyppa4isra3dorthbk5454hem 40 34 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 40 35 . . . work_rdyppa4isra3dorthbk5454hem 41 1 The the DT work_rdyppa4isra3dorthbk5454hem 41 2 horizontal horizontal JJ work_rdyppa4isra3dorthbk5454hem 41 3 line line NN work_rdyppa4isra3dorthbk5454hem 41 4 represents represent VBZ work_rdyppa4isra3dorthbk5454hem 41 5 the the DT work_rdyppa4isra3dorthbk5454hem 41 6 genomic genomic JJ work_rdyppa4isra3dorthbk5454hem 41 7 region region NN work_rdyppa4isra3dorthbk5454hem 41 8 covered cover VBN work_rdyppa4isra3dorthbk5454hem 41 9 by by IN work_rdyppa4isra3dorthbk5454hem 41 10 the the DT work_rdyppa4isra3dorthbk5454hem 41 11 gene gene NN work_rdyppa4isra3dorthbk5454hem 41 12 and and CC work_rdyppa4isra3dorthbk5454hem 41 13 the the DT work_rdyppa4isra3dorthbk5454hem 41 14 vertical vertical JJ work_rdyppa4isra3dorthbk5454hem 41 15 lines line NNS work_rdyppa4isra3dorthbk5454hem 41 16 represent represent VBP work_rdyppa4isra3dorthbk5454hem 41 17 the the DT work_rdyppa4isra3dorthbk5454hem 41 18 exons exon NNS work_rdyppa4isra3dorthbk5454hem 41 19 ; ; : work_rdyppa4isra3dorthbk5454hem 41 20 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 41 21 b b LS work_rdyppa4isra3dorthbk5454hem 41 22 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 41 23 The the DT work_rdyppa4isra3dorthbk5454hem 41 24 pedigree pedigree NN work_rdyppa4isra3dorthbk5454hem 41 25 of of IN work_rdyppa4isra3dorthbk5454hem 41 26 the the DT work_rdyppa4isra3dorthbk5454hem 41 27 t(7;15)(q35;q26.2 t(7;15)(q35;q26.2 NNP work_rdyppa4isra3dorthbk5454hem 41 28 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 41 29 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 41 30 family family NN work_rdyppa4isra3dorthbk5454hem 41 31 . . . work_rdyppa4isra3dorthbk5454hem 42 1 N n CC work_rdyppa4isra3dorthbk5454hem 42 2 , , , work_rdyppa4isra3dorthbk5454hem 42 3 normal normal JJ work_rdyppa4isra3dorthbk5454hem 42 4 karyotype karyotype NN work_rdyppa4isra3dorthbk5454hem 42 5 ; ; , work_rdyppa4isra3dorthbk5454hem 42 6 filled fill VBN work_rdyppa4isra3dorthbk5454hem 42 7 symbol symbol NN work_rdyppa4isra3dorthbk5454hem 42 8 , , , work_rdyppa4isra3dorthbk5454hem 42 9 unbalanced unbalanced JJ work_rdyppa4isra3dorthbk5454hem 42 10 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 42 11 46,XY 46,xy CD work_rdyppa4isra3dorthbk5454hem 42 12 / / SYM work_rdyppa4isra3dorthbk5454hem 42 13 XX XX NNP work_rdyppa4isra3dorthbk5454hem 42 14 , , , work_rdyppa4isra3dorthbk5454hem 42 15 der(7)t(7;15)(q35;q26.2 der(7)t(7;15)(q35;q26.2 NNP work_rdyppa4isra3dorthbk5454hem 42 16 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 42 17 ; ; : work_rdyppa4isra3dorthbk5454hem 42 18 symbol symbol NN work_rdyppa4isra3dorthbk5454hem 42 19 with with IN work_rdyppa4isra3dorthbk5454hem 42 20 dot dot NN work_rdyppa4isra3dorthbk5454hem 42 21 , , , work_rdyppa4isra3dorthbk5454hem 42 22 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 42 23 carrier carrier NN work_rdyppa4isra3dorthbk5454hem 42 24 . . . work_rdyppa4isra3dorthbk5454hem 43 1 Arrow Arrow NNP work_rdyppa4isra3dorthbk5454hem 43 2 indicates indicate VBZ work_rdyppa4isra3dorthbk5454hem 43 3 the the DT work_rdyppa4isra3dorthbk5454hem 43 4 index index NN work_rdyppa4isra3dorthbk5454hem 43 5 case case NN work_rdyppa4isra3dorthbk5454hem 43 6 . . . work_rdyppa4isra3dorthbk5454hem 44 1 Truncation truncation NN work_rdyppa4isra3dorthbk5454hem 44 2 of of IN work_rdyppa4isra3dorthbk5454hem 44 3 CNTNAP2 CNTNAP2 NNS work_rdyppa4isra3dorthbk5454hem 44 4 without without IN work_rdyppa4isra3dorthbk5454hem 44 5 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 44 6 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 44 7 JM JM NNP work_rdyppa4isra3dorthbk5454hem 44 8 Belloso Belloso NNP work_rdyppa4isra3dorthbk5454hem 44 9 et et NNP work_rdyppa4isra3dorthbk5454hem 44 10 al al NNP work_rdyppa4isra3dorthbk5454hem 44 11 712 712 CD work_rdyppa4isra3dorthbk5454hem 44 12 European European NNP work_rdyppa4isra3dorthbk5454hem 44 13 Journal Journal NNP work_rdyppa4isra3dorthbk5454hem 44 14 of of IN work_rdyppa4isra3dorthbk5454hem 44 15 Human Human NNP work_rdyppa4isra3dorthbk5454hem 44 16 Genetics Genetics NNPS work_rdyppa4isra3dorthbk5454hem 44 17 approximately approximately RB work_rdyppa4isra3dorthbk5454hem 44 18 90 90 CD work_rdyppa4isra3dorthbk5454hem 44 19 kb kb NN work_rdyppa4isra3dorthbk5454hem 44 20 region region NN work_rdyppa4isra3dorthbk5454hem 44 21 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 44 22 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 44 23 position position NN work_rdyppa4isra3dorthbk5454hem 44 24 , , , work_rdyppa4isra3dorthbk5454hem 44 25 91,713,990–91,805,103 91,713,990–91,805,103 CD work_rdyppa4isra3dorthbk5454hem 44 26 , , , work_rdyppa4isra3dorthbk5454hem 44 27 Human Human NNP work_rdyppa4isra3dorthbk5454hem 44 28 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 44 29 Browser Browser NNP work_rdyppa4isra3dorthbk5454hem 44 30 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 44 31 within within IN work_rdyppa4isra3dorthbk5454hem 44 32 a a DT work_rdyppa4isra3dorthbk5454hem 44 33 hypothetical hypothetical JJ work_rdyppa4isra3dorthbk5454hem 44 34 gene gene NN work_rdyppa4isra3dorthbk5454hem 44 35 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 44 36 AK094352 ak094352 NN work_rdyppa4isra3dorthbk5454hem 44 37 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 44 38 . . . work_rdyppa4isra3dorthbk5454hem 45 1 CGH CGH NNP work_rdyppa4isra3dorthbk5454hem 45 2 analysis analysis NN work_rdyppa4isra3dorthbk5454hem 45 3 did do VBD work_rdyppa4isra3dorthbk5454hem 45 4 not not RB work_rdyppa4isra3dorthbk5454hem 45 5 reveal reveal VB work_rdyppa4isra3dorthbk5454hem 45 6 loss loss NN work_rdyppa4isra3dorthbk5454hem 45 7 or or CC work_rdyppa4isra3dorthbk5454hem 45 8 gain gain NN work_rdyppa4isra3dorthbk5454hem 45 9 of of IN work_rdyppa4isra3dorthbk5454hem 45 10 any any DT work_rdyppa4isra3dorthbk5454hem 45 11 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 45 12 region region NN work_rdyppa4isra3dorthbk5454hem 45 13 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 45 14 data datum NNS work_rdyppa4isra3dorthbk5454hem 45 15 not not RB work_rdyppa4isra3dorthbk5454hem 45 16 shown show VBN work_rdyppa4isra3dorthbk5454hem 45 17 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 45 18 . . . work_rdyppa4isra3dorthbk5454hem 46 1 A a DT work_rdyppa4isra3dorthbk5454hem 46 2 homozygous homozygous JJ work_rdyppa4isra3dorthbk5454hem 46 3 mutation mutation NN work_rdyppa4isra3dorthbk5454hem 46 4 of of IN work_rdyppa4isra3dorthbk5454hem 46 5 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 46 6 has have VBZ work_rdyppa4isra3dorthbk5454hem 46 7 been be VBN work_rdyppa4isra3dorthbk5454hem 46 8 asso- asso- RB work_rdyppa4isra3dorthbk5454hem 46 9 ciated ciate VBN work_rdyppa4isra3dorthbk5454hem 46 10 with with IN work_rdyppa4isra3dorthbk5454hem 46 11 CDFE CDFE NNP work_rdyppa4isra3dorthbk5454hem 46 12 in in IN work_rdyppa4isra3dorthbk5454hem 46 13 the the DT work_rdyppa4isra3dorthbk5454hem 46 14 Old Old NNP work_rdyppa4isra3dorthbk5454hem 46 15 Order Order NNP work_rdyppa4isra3dorthbk5454hem 46 16 Amish Amish NNP work_rdyppa4isra3dorthbk5454hem 46 17 community,5 community,5 NNS work_rdyppa4isra3dorthbk5454hem 46 18 but but CC work_rdyppa4isra3dorthbk5454hem 46 19 it -PRON- PRP work_rdyppa4isra3dorthbk5454hem 46 20 is be VBZ work_rdyppa4isra3dorthbk5454hem 46 21 unknown unknown JJ work_rdyppa4isra3dorthbk5454hem 46 22 whether whether IN work_rdyppa4isra3dorthbk5454hem 46 23 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 46 24 mutations mutation NNS work_rdyppa4isra3dorthbk5454hem 46 25 result result VBP work_rdyppa4isra3dorthbk5454hem 46 26 in in IN work_rdyppa4isra3dorthbk5454hem 46 27 CDFE CDFE NNP work_rdyppa4isra3dorthbk5454hem 46 28 in in IN work_rdyppa4isra3dorthbk5454hem 46 29 other other JJ work_rdyppa4isra3dorthbk5454hem 46 30 populations population NNS work_rdyppa4isra3dorthbk5454hem 46 31 . . . work_rdyppa4isra3dorthbk5454hem 47 1 However however RB work_rdyppa4isra3dorthbk5454hem 47 2 , , , work_rdyppa4isra3dorthbk5454hem 47 3 the the DT work_rdyppa4isra3dorthbk5454hem 47 4 present present JJ work_rdyppa4isra3dorthbk5454hem 47 5 case case NN work_rdyppa4isra3dorthbk5454hem 47 6 supports support VBZ work_rdyppa4isra3dorthbk5454hem 47 7 the the DT work_rdyppa4isra3dorthbk5454hem 47 8 finding finding NN work_rdyppa4isra3dorthbk5454hem 47 9 that that DT work_rdyppa4isra3dorthbk5454hem 47 10 disruption disruption NN work_rdyppa4isra3dorthbk5454hem 47 11 of of IN work_rdyppa4isra3dorthbk5454hem 47 12 a a DT work_rdyppa4isra3dorthbk5454hem 47 13 single single JJ work_rdyppa4isra3dorthbk5454hem 47 14 allele allele NN work_rdyppa4isra3dorthbk5454hem 47 15 of of IN work_rdyppa4isra3dorthbk5454hem 47 16 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 47 17 does do VBZ work_rdyppa4isra3dorthbk5454hem 47 18 not not RB work_rdyppa4isra3dorthbk5454hem 47 19 lead lead VB work_rdyppa4isra3dorthbk5454hem 47 20 to to IN work_rdyppa4isra3dorthbk5454hem 47 21 CDFE CDFE NNP work_rdyppa4isra3dorthbk5454hem 47 22 , , , work_rdyppa4isra3dorthbk5454hem 47 23 in in IN work_rdyppa4isra3dorthbk5454hem 47 24 line line NN work_rdyppa4isra3dorthbk5454hem 47 25 with with IN work_rdyppa4isra3dorthbk5454hem 47 26 the the DT work_rdyppa4isra3dorthbk5454hem 47 27 suggested suggest VBN work_rdyppa4isra3dorthbk5454hem 47 28 recessive- recessive- NN work_rdyppa4isra3dorthbk5454hem 47 29 inheritance.5 inheritance.5 IN work_rdyppa4isra3dorthbk5454hem 47 30 Verkerk verkerk NN work_rdyppa4isra3dorthbk5454hem 47 31 and and CC work_rdyppa4isra3dorthbk5454hem 47 32 colleagues6 colleagues6 NN work_rdyppa4isra3dorthbk5454hem 47 33 suggested suggest VBD work_rdyppa4isra3dorthbk5454hem 47 34 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 47 35 as as IN work_rdyppa4isra3dorthbk5454hem 47 36 a a DT work_rdyppa4isra3dorthbk5454hem 47 37 candidate candidate NN work_rdyppa4isra3dorthbk5454hem 47 38 gene gene NN work_rdyppa4isra3dorthbk5454hem 47 39 for for IN work_rdyppa4isra3dorthbk5454hem 47 40 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 47 41 based base VBN work_rdyppa4isra3dorthbk5454hem 47 42 on on IN work_rdyppa4isra3dorthbk5454hem 47 43 the the DT work_rdyppa4isra3dorthbk5454hem 47 44 finding finding NN work_rdyppa4isra3dorthbk5454hem 47 45 of of IN work_rdyppa4isra3dorthbk5454hem 47 46 a a DT work_rdyppa4isra3dorthbk5454hem 47 47 truncating truncate VBG work_rdyppa4isra3dorthbk5454hem 47 48 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 47 49 breakpoint breakpoint NN work_rdyppa4isra3dorthbk5454hem 47 50 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 47 51 Figure Figure NNP work_rdyppa4isra3dorthbk5454hem 47 52 1a 1a NNP work_rdyppa4isra3dorthbk5454hem 47 53 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 47 54 . . . work_rdyppa4isra3dorthbk5454hem 48 1 The the DT work_rdyppa4isra3dorthbk5454hem 48 2 authors author NNS work_rdyppa4isra3dorthbk5454hem 48 3 hypothesized hypothesize VBD work_rdyppa4isra3dorthbk5454hem 48 4 that that DT work_rdyppa4isra3dorthbk5454hem 48 5 disruption disruption NN work_rdyppa4isra3dorthbk5454hem 48 6 of of IN work_rdyppa4isra3dorthbk5454hem 48 7 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 48 8 would would MD work_rdyppa4isra3dorthbk5454hem 48 9 lead lead VB work_rdyppa4isra3dorthbk5454hem 48 10 to to IN work_rdyppa4isra3dorthbk5454hem 48 11 decreased decrease VBN work_rdyppa4isra3dorthbk5454hem 48 12 gene gene NN work_rdyppa4isra3dorthbk5454hem 48 13 expression expression NN work_rdyppa4isra3dorthbk5454hem 48 14 , , , work_rdyppa4isra3dorthbk5454hem 48 15 which which WDT work_rdyppa4isra3dorthbk5454hem 48 16 in in IN work_rdyppa4isra3dorthbk5454hem 48 17 turn turn NN work_rdyppa4isra3dorthbk5454hem 48 18 would would MD work_rdyppa4isra3dorthbk5454hem 48 19 affect affect VB work_rdyppa4isra3dorthbk5454hem 48 20 localization localization NN work_rdyppa4isra3dorthbk5454hem 48 21 and/or and/or CC work_rdyppa4isra3dorthbk5454hem 48 22 maintenance maintenance NN work_rdyppa4isra3dorthbk5454hem 48 23 of of IN work_rdyppa4isra3dorthbk5454hem 48 24 Kv1 Kv1 NNP work_rdyppa4isra3dorthbk5454hem 48 25 channels channel NNS work_rdyppa4isra3dorthbk5454hem 48 26 . . . work_rdyppa4isra3dorthbk5454hem 49 1 This this DT work_rdyppa4isra3dorthbk5454hem 49 2 would would MD work_rdyppa4isra3dorthbk5454hem 49 3 influence influence VB work_rdyppa4isra3dorthbk5454hem 49 4 conduction conduction NN work_rdyppa4isra3dorthbk5454hem 49 5 and/or and/or CC work_rdyppa4isra3dorthbk5454hem 49 6 re re NN work_rdyppa4isra3dorthbk5454hem 49 7 - - NN work_rdyppa4isra3dorthbk5454hem 49 8 polarization polarization NN work_rdyppa4isra3dorthbk5454hem 49 9 of of IN work_rdyppa4isra3dorthbk5454hem 49 10 action action NN work_rdyppa4isra3dorthbk5454hem 49 11 potentials potential NNS work_rdyppa4isra3dorthbk5454hem 49 12 in in IN work_rdyppa4isra3dorthbk5454hem 49 13 certain certain JJ work_rdyppa4isra3dorthbk5454hem 49 14 brain brain NN work_rdyppa4isra3dorthbk5454hem 49 15 regions region NNS work_rdyppa4isra3dorthbk5454hem 49 16 sensitive sensitive JJ work_rdyppa4isra3dorthbk5454hem 49 17 to to IN work_rdyppa4isra3dorthbk5454hem 49 18 these these DT work_rdyppa4isra3dorthbk5454hem 49 19 changes change NNS work_rdyppa4isra3dorthbk5454hem 49 20 , , , work_rdyppa4isra3dorthbk5454hem 49 21 resulting result VBG work_rdyppa4isra3dorthbk5454hem 49 22 in in IN work_rdyppa4isra3dorthbk5454hem 49 23 a a DT work_rdyppa4isra3dorthbk5454hem 49 24 diminished diminished JJ work_rdyppa4isra3dorthbk5454hem 49 25 inhibition inhibition NN work_rdyppa4isra3dorthbk5454hem 49 26 of of IN work_rdyppa4isra3dorthbk5454hem 49 27 unwanted unwanted JJ work_rdyppa4isra3dorthbk5454hem 49 28 tics tic NNS work_rdyppa4isra3dorthbk5454hem 49 29 as as IN work_rdyppa4isra3dorthbk5454hem 49 30 observed observe VBN work_rdyppa4isra3dorthbk5454hem 49 31 in in IN work_rdyppa4isra3dorthbk5454hem 49 32 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 49 33 . . . work_rdyppa4isra3dorthbk5454hem 50 1 The the DT work_rdyppa4isra3dorthbk5454hem 50 2 absence absence NN work_rdyppa4isra3dorthbk5454hem 50 3 of of IN work_rdyppa4isra3dorthbk5454hem 50 4 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 50 5 symptoms symptom NNS work_rdyppa4isra3dorthbk5454hem 50 6 in in IN work_rdyppa4isra3dorthbk5454hem 50 7 the the DT work_rdyppa4isra3dorthbk5454hem 50 8 present present JJ work_rdyppa4isra3dorthbk5454hem 50 9 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 50 10 family family NN work_rdyppa4isra3dorthbk5454hem 50 11 indicates indicate VBZ work_rdyppa4isra3dorthbk5454hem 50 12 that that IN work_rdyppa4isra3dorthbk5454hem 50 13 disruption disruption NN work_rdyppa4isra3dorthbk5454hem 50 14 of of IN work_rdyppa4isra3dorthbk5454hem 50 15 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 50 16 does do VBZ work_rdyppa4isra3dorthbk5454hem 50 17 not not RB work_rdyppa4isra3dorthbk5454hem 50 18 necessarily necessarily RB work_rdyppa4isra3dorthbk5454hem 50 19 lead lead VB work_rdyppa4isra3dorthbk5454hem 50 20 to to IN work_rdyppa4isra3dorthbk5454hem 50 21 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 50 22 . . . work_rdyppa4isra3dorthbk5454hem 51 1 However however RB work_rdyppa4isra3dorthbk5454hem 51 2 , , , work_rdyppa4isra3dorthbk5454hem 51 3 taking take VBG work_rdyppa4isra3dorthbk5454hem 51 4 into into IN work_rdyppa4isra3dorthbk5454hem 51 5 consideration consideration NN work_rdyppa4isra3dorthbk5454hem 51 6 the the DT work_rdyppa4isra3dorthbk5454hem 51 7 complex complex JJ work_rdyppa4isra3dorthbk5454hem 51 8 etiology etiology NN work_rdyppa4isra3dorthbk5454hem 51 9 of of IN work_rdyppa4isra3dorthbk5454hem 51 10 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 51 11 with with IN work_rdyppa4isra3dorthbk5454hem 51 12 a a DT work_rdyppa4isra3dorthbk5454hem 51 13 probable probable JJ work_rdyppa4isra3dorthbk5454hem 51 14 polygenic polygenic JJ work_rdyppa4isra3dorthbk5454hem 51 15 character character NN work_rdyppa4isra3dorthbk5454hem 51 16 , , , work_rdyppa4isra3dorthbk5454hem 51 17 this this DT work_rdyppa4isra3dorthbk5454hem 51 18 finding finding NN work_rdyppa4isra3dorthbk5454hem 51 19 does do VBZ work_rdyppa4isra3dorthbk5454hem 51 20 not not RB work_rdyppa4isra3dorthbk5454hem 51 21 strictly strictly RB work_rdyppa4isra3dorthbk5454hem 51 22 exclude exclude VB work_rdyppa4isra3dorthbk5454hem 51 23 the the DT work_rdyppa4isra3dorthbk5454hem 51 24 involvement involvement NN work_rdyppa4isra3dorthbk5454hem 51 25 of of IN work_rdyppa4isra3dorthbk5454hem 51 26 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 51 27 in in IN work_rdyppa4isra3dorthbk5454hem 51 28 GTS GTS NNP work_rdyppa4isra3dorthbk5454hem 51 29 pathogenesis pathogenesis NN work_rdyppa4isra3dorthbk5454hem 51 30 . . . work_rdyppa4isra3dorthbk5454hem 52 1 Acknowledgements acknowledgement NNS work_rdyppa4isra3dorthbk5454hem 52 2 We -PRON- PRP work_rdyppa4isra3dorthbk5454hem 52 3 are be VBP work_rdyppa4isra3dorthbk5454hem 52 4 grateful grateful JJ work_rdyppa4isra3dorthbk5454hem 52 5 to to IN work_rdyppa4isra3dorthbk5454hem 52 6 the the DT work_rdyppa4isra3dorthbk5454hem 52 7 family family NN work_rdyppa4isra3dorthbk5454hem 52 8 for for IN work_rdyppa4isra3dorthbk5454hem 52 9 their -PRON- PRP$ work_rdyppa4isra3dorthbk5454hem 52 10 cooperation cooperation NN work_rdyppa4isra3dorthbk5454hem 52 11 . . . work_rdyppa4isra3dorthbk5454hem 53 1 We -PRON- PRP work_rdyppa4isra3dorthbk5454hem 53 2 thank thank VBP work_rdyppa4isra3dorthbk5454hem 53 3 Minna Minna NNP work_rdyppa4isra3dorthbk5454hem 53 4 Becher Becher NNP work_rdyppa4isra3dorthbk5454hem 53 5 , , , work_rdyppa4isra3dorthbk5454hem 53 6 Karen Karen NNP work_rdyppa4isra3dorthbk5454hem 53 7 Friis Friis NNP work_rdyppa4isra3dorthbk5454hem 53 8 Henriksen Henriksen NNP work_rdyppa4isra3dorthbk5454hem 53 9 , , , work_rdyppa4isra3dorthbk5454hem 53 10 Anita Anita NNP work_rdyppa4isra3dorthbk5454hem 53 11 Niebuhr Niebuhr NNP work_rdyppa4isra3dorthbk5454hem 53 12 , , , work_rdyppa4isra3dorthbk5454hem 53 13 Kirsten Kirsten NNP work_rdyppa4isra3dorthbk5454hem 53 14 Winther Winther NNP work_rdyppa4isra3dorthbk5454hem 53 15 for for IN work_rdyppa4isra3dorthbk5454hem 53 16 their -PRON- PRP$ work_rdyppa4isra3dorthbk5454hem 53 17 skillful skillful JJ work_rdyppa4isra3dorthbk5454hem 53 18 technical technical JJ work_rdyppa4isra3dorthbk5454hem 53 19 assistance assistance NN work_rdyppa4isra3dorthbk5454hem 53 20 . . . work_rdyppa4isra3dorthbk5454hem 54 1 Wilhelm Wilhelm NNP work_rdyppa4isra3dorthbk5454hem 54 2 Johannsen Johannsen NNP work_rdyppa4isra3dorthbk5454hem 54 3 Centre Centre NNP work_rdyppa4isra3dorthbk5454hem 54 4 for for IN work_rdyppa4isra3dorthbk5454hem 54 5 Functional Functional NNP work_rdyppa4isra3dorthbk5454hem 54 6 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 54 7 Research Research NNP work_rdyppa4isra3dorthbk5454hem 54 8 is be VBZ work_rdyppa4isra3dorthbk5454hem 54 9 established establish VBN work_rdyppa4isra3dorthbk5454hem 54 10 by by IN work_rdyppa4isra3dorthbk5454hem 54 11 The the DT work_rdyppa4isra3dorthbk5454hem 54 12 Danish Danish NNP work_rdyppa4isra3dorthbk5454hem 54 13 National National NNP work_rdyppa4isra3dorthbk5454hem 54 14 Research Research NNP work_rdyppa4isra3dorthbk5454hem 54 15 Foundation Foundation NNP work_rdyppa4isra3dorthbk5454hem 54 16 . . . work_rdyppa4isra3dorthbk5454hem 55 1 Online online JJ work_rdyppa4isra3dorthbk5454hem 55 2 information information NN work_rdyppa4isra3dorthbk5454hem 55 3 Online Online NNP work_rdyppa4isra3dorthbk5454hem 55 4 Mendelian Mendelian NNP work_rdyppa4isra3dorthbk5454hem 55 5 Inherance Inherance NNP work_rdyppa4isra3dorthbk5454hem 55 6 in in IN work_rdyppa4isra3dorthbk5454hem 55 7 Man Man NNP work_rdyppa4isra3dorthbk5454hem 55 8 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 55 9 OMIM OMIM NNP work_rdyppa4isra3dorthbk5454hem 55 10 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 55 11 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 55 12 http:// http:// NNP work_rdyppa4isra3dorthbk5454hem 55 13 www.ncbi.nlm.nih.gov/entrez/query.fcgi?db www.ncbi.nlm.nih.gov/entrez/query.fcgi?db NNP work_rdyppa4isra3dorthbk5454hem 55 14 ¼ ¼ NNP work_rdyppa4isra3dorthbk5454hem 55 15 OMIM OMIM NNP work_rdyppa4isra3dorthbk5454hem 55 16 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 55 17 . . . work_rdyppa4isra3dorthbk5454hem 56 1 Human human JJ work_rdyppa4isra3dorthbk5454hem 56 2 Genome Genome NNP work_rdyppa4isra3dorthbk5454hem 56 3 Browser Browser NNP work_rdyppa4isra3dorthbk5454hem 56 4 , , , work_rdyppa4isra3dorthbk5454hem 56 5 UCSC UCSC NNP work_rdyppa4isra3dorthbk5454hem 56 6 genome genome JJ work_rdyppa4isra3dorthbk5454hem 56 7 bioinformatics bioinformatic NNS work_rdyppa4isra3dorthbk5454hem 56 8 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 56 9 http:// http:// NNP work_rdyppa4isra3dorthbk5454hem 56 10 genome.ucsc.edu/cgi-bin/hgGateway genome.ucsc.edu/cgi-bin/hgGateway NNP work_rdyppa4isra3dorthbk5454hem 56 11 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 56 12 . . . work_rdyppa4isra3dorthbk5454hem 57 1 References reference NNS work_rdyppa4isra3dorthbk5454hem 57 2 1 1 CD work_rdyppa4isra3dorthbk5454hem 57 3 Rasband rasband NN work_rdyppa4isra3dorthbk5454hem 57 4 MN MN NNP work_rdyppa4isra3dorthbk5454hem 57 5 : : : work_rdyppa4isra3dorthbk5454hem 57 6 It -PRON- PRP work_rdyppa4isra3dorthbk5454hem 57 7 ’s ’ VBZ work_rdyppa4isra3dorthbk5454hem 57 8 ‘ ' `` work_rdyppa4isra3dorthbk5454hem 57 9 juxta juxta NNP work_rdyppa4isra3dorthbk5454hem 57 10 ’ ' '' work_rdyppa4isra3dorthbk5454hem 57 11 potassium potassium NN work_rdyppa4isra3dorthbk5454hem 57 12 channel channel NNP work_rdyppa4isra3dorthbk5454hem 57 13 ! ! . work_rdyppa4isra3dorthbk5454hem 57 14 . . . work_rdyppa4isra3dorthbk5454hem 58 1 J J NNP work_rdyppa4isra3dorthbk5454hem 58 2 Neurosci Neurosci NNP work_rdyppa4isra3dorthbk5454hem 58 3 Res Res NNP work_rdyppa4isra3dorthbk5454hem 58 4 2004 2004 CD work_rdyppa4isra3dorthbk5454hem 58 5 ; ; : work_rdyppa4isra3dorthbk5454hem 58 6 76 76 CD work_rdyppa4isra3dorthbk5454hem 58 7 : : : work_rdyppa4isra3dorthbk5454hem 58 8 749–757 749–757 CD work_rdyppa4isra3dorthbk5454hem 58 9 . . . work_rdyppa4isra3dorthbk5454hem 59 1 2 2 CD work_rdyppa4isra3dorthbk5454hem 59 2 Poliak Poliak NNP work_rdyppa4isra3dorthbk5454hem 59 3 S S NNP work_rdyppa4isra3dorthbk5454hem 59 4 , , , work_rdyppa4isra3dorthbk5454hem 59 5 Gollan Gollan NNP work_rdyppa4isra3dorthbk5454hem 59 6 L L NNP work_rdyppa4isra3dorthbk5454hem 59 7 , , , work_rdyppa4isra3dorthbk5454hem 59 8 Martinez Martinez NNP work_rdyppa4isra3dorthbk5454hem 59 9 R R NNP work_rdyppa4isra3dorthbk5454hem 59 10 et et NNP work_rdyppa4isra3dorthbk5454hem 59 11 al al NNP work_rdyppa4isra3dorthbk5454hem 59 12 : : : work_rdyppa4isra3dorthbk5454hem 59 13 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 59 14 , , , work_rdyppa4isra3dorthbk5454hem 59 15 a a DT work_rdyppa4isra3dorthbk5454hem 59 16 new new JJ work_rdyppa4isra3dorthbk5454hem 59 17 member member NN work_rdyppa4isra3dorthbk5454hem 59 18 of of IN work_rdyppa4isra3dorthbk5454hem 59 19 the the DT work_rdyppa4isra3dorthbk5454hem 59 20 neurexin neurexin NNP work_rdyppa4isra3dorthbk5454hem 59 21 superfamily superfamily NNP work_rdyppa4isra3dorthbk5454hem 59 22 , , , work_rdyppa4isra3dorthbk5454hem 59 23 is be VBZ work_rdyppa4isra3dorthbk5454hem 59 24 localized localize VBN work_rdyppa4isra3dorthbk5454hem 59 25 at at IN work_rdyppa4isra3dorthbk5454hem 59 26 the the DT work_rdyppa4isra3dorthbk5454hem 59 27 juxtaparanodes juxtaparanode NNS work_rdyppa4isra3dorthbk5454hem 59 28 of of IN work_rdyppa4isra3dorthbk5454hem 59 29 myelinated myelinated JJ work_rdyppa4isra3dorthbk5454hem 59 30 axons axon NNS work_rdyppa4isra3dorthbk5454hem 59 31 and and CC work_rdyppa4isra3dorthbk5454hem 59 32 associates associate NNS work_rdyppa4isra3dorthbk5454hem 59 33 with with IN work_rdyppa4isra3dorthbk5454hem 59 34 K+ K+ NNP work_rdyppa4isra3dorthbk5454hem 59 35 channels channel NNS work_rdyppa4isra3dorthbk5454hem 59 36 . . . work_rdyppa4isra3dorthbk5454hem 60 1 Neuron Neuron NNP work_rdyppa4isra3dorthbk5454hem 60 2 1999 1999 CD work_rdyppa4isra3dorthbk5454hem 60 3 ; ; : work_rdyppa4isra3dorthbk5454hem 60 4 24 24 CD work_rdyppa4isra3dorthbk5454hem 60 5 : : SYM work_rdyppa4isra3dorthbk5454hem 60 6 1037–1047 1037–1047 CD work_rdyppa4isra3dorthbk5454hem 60 7 . . . work_rdyppa4isra3dorthbk5454hem 61 1 3 3 CD work_rdyppa4isra3dorthbk5454hem 61 2 Poliak Poliak NNP work_rdyppa4isra3dorthbk5454hem 61 3 S S NNP work_rdyppa4isra3dorthbk5454hem 61 4 , , , work_rdyppa4isra3dorthbk5454hem 61 5 Salomon Salomon NNP work_rdyppa4isra3dorthbk5454hem 61 6 D D NNP work_rdyppa4isra3dorthbk5454hem 61 7 , , , work_rdyppa4isra3dorthbk5454hem 61 8 Elhanany Elhanany NNP work_rdyppa4isra3dorthbk5454hem 61 9 H H NNP work_rdyppa4isra3dorthbk5454hem 61 10 et et NN work_rdyppa4isra3dorthbk5454hem 61 11 al al NNP work_rdyppa4isra3dorthbk5454hem 61 12 : : : work_rdyppa4isra3dorthbk5454hem 61 13 Juxtaparanodal Juxtaparanodal NNP work_rdyppa4isra3dorthbk5454hem 61 14 clustering cluster VBG work_rdyppa4isra3dorthbk5454hem 61 15 of of IN work_rdyppa4isra3dorthbk5454hem 61 16 Shaker Shaker NNP work_rdyppa4isra3dorthbk5454hem 61 17 - - HYPH work_rdyppa4isra3dorthbk5454hem 61 18 like like JJ work_rdyppa4isra3dorthbk5454hem 61 19 K K NNP work_rdyppa4isra3dorthbk5454hem 61 20 � � NNP work_rdyppa4isra3dorthbk5454hem 61 21 channels channel NNS work_rdyppa4isra3dorthbk5454hem 61 22 in in IN work_rdyppa4isra3dorthbk5454hem 61 23 myelinated myelinated JJ work_rdyppa4isra3dorthbk5454hem 61 24 axons axon NNS work_rdyppa4isra3dorthbk5454hem 61 25 depends depend VBZ work_rdyppa4isra3dorthbk5454hem 61 26 on on IN work_rdyppa4isra3dorthbk5454hem 61 27 Caspr2 Caspr2 NNP work_rdyppa4isra3dorthbk5454hem 61 28 and and CC work_rdyppa4isra3dorthbk5454hem 61 29 TAG-1 TAG-1 NNP work_rdyppa4isra3dorthbk5454hem 61 30 . . . work_rdyppa4isra3dorthbk5454hem 62 1 J J NNP work_rdyppa4isra3dorthbk5454hem 62 2 Cell Cell NNP work_rdyppa4isra3dorthbk5454hem 62 3 Biol Biol NNP work_rdyppa4isra3dorthbk5454hem 62 4 2003 2003 CD work_rdyppa4isra3dorthbk5454hem 62 5 ; ; : work_rdyppa4isra3dorthbk5454hem 62 6 162 162 CD work_rdyppa4isra3dorthbk5454hem 62 7 : : SYM work_rdyppa4isra3dorthbk5454hem 62 8 1149–1160 1149–1160 CD work_rdyppa4isra3dorthbk5454hem 62 9 . . . work_rdyppa4isra3dorthbk5454hem 63 1 4 4 LS work_rdyppa4isra3dorthbk5454hem 63 2 Nakabayashi Nakabayashi NNP work_rdyppa4isra3dorthbk5454hem 63 3 K K NNP work_rdyppa4isra3dorthbk5454hem 63 4 , , , work_rdyppa4isra3dorthbk5454hem 63 5 Scherer Scherer NNP work_rdyppa4isra3dorthbk5454hem 63 6 SW SW NNP work_rdyppa4isra3dorthbk5454hem 63 7 : : : work_rdyppa4isra3dorthbk5454hem 63 8 The the DT work_rdyppa4isra3dorthbk5454hem 63 9 human human JJ work_rdyppa4isra3dorthbk5454hem 63 10 contactin contactin NN work_rdyppa4isra3dorthbk5454hem 63 11 - - HYPH work_rdyppa4isra3dorthbk5454hem 63 12 associated associate VBN work_rdyppa4isra3dorthbk5454hem 63 13 protein protein NN work_rdyppa4isra3dorthbk5454hem 63 14 - - HYPH work_rdyppa4isra3dorthbk5454hem 63 15 like like JJ work_rdyppa4isra3dorthbk5454hem 63 16 2 2 CD work_rdyppa4isra3dorthbk5454hem 63 17 gene gene NN work_rdyppa4isra3dorthbk5454hem 63 18 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 63 19 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 63 20 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 63 21 spans span NNS work_rdyppa4isra3dorthbk5454hem 63 22 over over IN work_rdyppa4isra3dorthbk5454hem 63 23 2 2 CD work_rdyppa4isra3dorthbk5454hem 63 24 Mb Mb NNP work_rdyppa4isra3dorthbk5454hem 63 25 of of IN work_rdyppa4isra3dorthbk5454hem 63 26 DNA DNA NNP work_rdyppa4isra3dorthbk5454hem 63 27 at at IN work_rdyppa4isra3dorthbk5454hem 63 28 chromosome chromosome NN work_rdyppa4isra3dorthbk5454hem 63 29 7q35 7q35 CD work_rdyppa4isra3dorthbk5454hem 63 30 . . . work_rdyppa4isra3dorthbk5454hem 64 1 Genomics Genomics NNP work_rdyppa4isra3dorthbk5454hem 64 2 2001 2001 CD work_rdyppa4isra3dorthbk5454hem 64 3 ; ; : work_rdyppa4isra3dorthbk5454hem 64 4 73 73 CD work_rdyppa4isra3dorthbk5454hem 64 5 : : : work_rdyppa4isra3dorthbk5454hem 64 6 108–112 108–112 CD work_rdyppa4isra3dorthbk5454hem 64 7 . . . work_rdyppa4isra3dorthbk5454hem 65 1 5 5 CD work_rdyppa4isra3dorthbk5454hem 65 2 Strauss Strauss NNP work_rdyppa4isra3dorthbk5454hem 65 3 KA KA NNP work_rdyppa4isra3dorthbk5454hem 65 4 , , , work_rdyppa4isra3dorthbk5454hem 65 5 Puffenberger Puffenberger NNP work_rdyppa4isra3dorthbk5454hem 65 6 EG EG NNP work_rdyppa4isra3dorthbk5454hem 65 7 , , , work_rdyppa4isra3dorthbk5454hem 65 8 Huentelman Huentelman NNP work_rdyppa4isra3dorthbk5454hem 65 9 MJ MJ NNP work_rdyppa4isra3dorthbk5454hem 65 10 et et NNP work_rdyppa4isra3dorthbk5454hem 65 11 al al NNP work_rdyppa4isra3dorthbk5454hem 65 12 : : : work_rdyppa4isra3dorthbk5454hem 65 13 Recessive recessive JJ work_rdyppa4isra3dorthbk5454hem 65 14 symptomatic symptomatic JJ work_rdyppa4isra3dorthbk5454hem 65 15 focal focal JJ work_rdyppa4isra3dorthbk5454hem 65 16 epilepsy epilepsy NN work_rdyppa4isra3dorthbk5454hem 65 17 and and CC work_rdyppa4isra3dorthbk5454hem 65 18 mutant mutant JJ work_rdyppa4isra3dorthbk5454hem 65 19 contactin contactin NN work_rdyppa4isra3dorthbk5454hem 65 20 - - HYPH work_rdyppa4isra3dorthbk5454hem 65 21 associated associate VBN work_rdyppa4isra3dorthbk5454hem 65 22 protein protein NN work_rdyppa4isra3dorthbk5454hem 65 23 - - HYPH work_rdyppa4isra3dorthbk5454hem 65 24 like like JJ work_rdyppa4isra3dorthbk5454hem 65 25 2 2 CD work_rdyppa4isra3dorthbk5454hem 65 26 . . . work_rdyppa4isra3dorthbk5454hem 66 1 New New NNP work_rdyppa4isra3dorthbk5454hem 66 2 Eng Eng NNP work_rdyppa4isra3dorthbk5454hem 66 3 J J NNP work_rdyppa4isra3dorthbk5454hem 66 4 Med Med NNP work_rdyppa4isra3dorthbk5454hem 66 5 2006 2006 CD work_rdyppa4isra3dorthbk5454hem 66 6 ; ; : work_rdyppa4isra3dorthbk5454hem 66 7 354 354 CD work_rdyppa4isra3dorthbk5454hem 66 8 : : SYM work_rdyppa4isra3dorthbk5454hem 66 9 1370–1377 1370–1377 CD work_rdyppa4isra3dorthbk5454hem 66 10 . . . work_rdyppa4isra3dorthbk5454hem 67 1 6 6 CD work_rdyppa4isra3dorthbk5454hem 67 2 Verkerk Verkerk NNP work_rdyppa4isra3dorthbk5454hem 67 3 AJMH AJMH NNP work_rdyppa4isra3dorthbk5454hem 67 4 , , , work_rdyppa4isra3dorthbk5454hem 67 5 Mathews Mathews NNP work_rdyppa4isra3dorthbk5454hem 67 6 CA CA NNP work_rdyppa4isra3dorthbk5454hem 67 7 , , , work_rdyppa4isra3dorthbk5454hem 67 8 Joosse Joosse NNP work_rdyppa4isra3dorthbk5454hem 67 9 M M NNP work_rdyppa4isra3dorthbk5454hem 67 10 et et NNP work_rdyppa4isra3dorthbk5454hem 67 11 al al NNP work_rdyppa4isra3dorthbk5454hem 67 12 : : : work_rdyppa4isra3dorthbk5454hem 67 13 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 67 14 is be VBZ work_rdyppa4isra3dorthbk5454hem 67 15 disrupted disrupt VBN work_rdyppa4isra3dorthbk5454hem 67 16 in in IN work_rdyppa4isra3dorthbk5454hem 67 17 a a DT work_rdyppa4isra3dorthbk5454hem 67 18 family family NN work_rdyppa4isra3dorthbk5454hem 67 19 with with IN work_rdyppa4isra3dorthbk5454hem 67 20 Gilles Gilles NNP work_rdyppa4isra3dorthbk5454hem 67 21 de de FW work_rdyppa4isra3dorthbk5454hem 67 22 la la FW work_rdyppa4isra3dorthbk5454hem 67 23 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 67 24 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 67 25 and and CC work_rdyppa4isra3dorthbk5454hem 67 26 obsessive obsessive JJ work_rdyppa4isra3dorthbk5454hem 67 27 compulsive compulsive JJ work_rdyppa4isra3dorthbk5454hem 67 28 disorder disorder NN work_rdyppa4isra3dorthbk5454hem 67 29 . . . work_rdyppa4isra3dorthbk5454hem 68 1 Genomics Genomics NNP work_rdyppa4isra3dorthbk5454hem 68 2 2003 2003 CD work_rdyppa4isra3dorthbk5454hem 68 3 ; ; : work_rdyppa4isra3dorthbk5454hem 68 4 82 82 CD work_rdyppa4isra3dorthbk5454hem 68 5 : : SYM work_rdyppa4isra3dorthbk5454hem 68 6 1–9 1–9 CD work_rdyppa4isra3dorthbk5454hem 68 7 . . . work_rdyppa4isra3dorthbk5454hem 69 1 7 7 CD work_rdyppa4isra3dorthbk5454hem 69 2 American American NNP work_rdyppa4isra3dorthbk5454hem 69 3 Psychiatric Psychiatric NNP work_rdyppa4isra3dorthbk5454hem 69 4 Association Association NNP work_rdyppa4isra3dorthbk5454hem 69 5 : : : work_rdyppa4isra3dorthbk5454hem 69 6 Diagnostic Diagnostic NNP work_rdyppa4isra3dorthbk5454hem 69 7 and and CC work_rdyppa4isra3dorthbk5454hem 69 8 Statistical Statistical NNP work_rdyppa4isra3dorthbk5454hem 69 9 Manual Manual NNP work_rdyppa4isra3dorthbk5454hem 69 10 of of IN work_rdyppa4isra3dorthbk5454hem 69 11 Mental Mental NNP work_rdyppa4isra3dorthbk5454hem 69 12 Disorders Disorders NNPS work_rdyppa4isra3dorthbk5454hem 69 13 , , , work_rdyppa4isra3dorthbk5454hem 69 14 Fourth Fourth NNP work_rdyppa4isra3dorthbk5454hem 69 15 Edition Edition NNP work_rdyppa4isra3dorthbk5454hem 69 16 ( ( -LRB- work_rdyppa4isra3dorthbk5454hem 69 17 DSM DSM NNP work_rdyppa4isra3dorthbk5454hem 69 18 - - HYPH work_rdyppa4isra3dorthbk5454hem 69 19 IV IV NNP work_rdyppa4isra3dorthbk5454hem 69 20 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 69 21 , , , work_rdyppa4isra3dorthbk5454hem 69 22 Washington Washington NNP work_rdyppa4isra3dorthbk5454hem 69 23 DC DC NNP work_rdyppa4isra3dorthbk5454hem 69 24 , , , work_rdyppa4isra3dorthbk5454hem 69 25 1994 1994 CD work_rdyppa4isra3dorthbk5454hem 69 26 . . . work_rdyppa4isra3dorthbk5454hem 70 1 8 8 CD work_rdyppa4isra3dorthbk5454hem 70 2 Pauls Pauls NNP work_rdyppa4isra3dorthbk5454hem 70 3 DL DL NNP work_rdyppa4isra3dorthbk5454hem 70 4 : : : work_rdyppa4isra3dorthbk5454hem 70 5 Update update NN work_rdyppa4isra3dorthbk5454hem 70 6 on on IN work_rdyppa4isra3dorthbk5454hem 70 7 the the DT work_rdyppa4isra3dorthbk5454hem 70 8 genetics genetic NNS work_rdyppa4isra3dorthbk5454hem 70 9 of of IN work_rdyppa4isra3dorthbk5454hem 70 10 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 70 11 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 70 12 . . . work_rdyppa4isra3dorthbk5454hem 71 1 Adv Adv NNP work_rdyppa4isra3dorthbk5454hem 71 2 Neurol Neurol NNP work_rdyppa4isra3dorthbk5454hem 71 3 2001 2001 CD work_rdyppa4isra3dorthbk5454hem 71 4 ; ; : work_rdyppa4isra3dorthbk5454hem 71 5 85 85 CD work_rdyppa4isra3dorthbk5454hem 71 6 : : SYM work_rdyppa4isra3dorthbk5454hem 71 7 281–293 281–293 CD work_rdyppa4isra3dorthbk5454hem 71 8 . . . work_rdyppa4isra3dorthbk5454hem 72 1 9 9 CD work_rdyppa4isra3dorthbk5454hem 72 2 Abelson Abelson NNP work_rdyppa4isra3dorthbk5454hem 72 3 JF JF NNP work_rdyppa4isra3dorthbk5454hem 72 4 , , , work_rdyppa4isra3dorthbk5454hem 72 5 Kwan Kwan NNP work_rdyppa4isra3dorthbk5454hem 72 6 KY KY NNP work_rdyppa4isra3dorthbk5454hem 72 7 , , , work_rdyppa4isra3dorthbk5454hem 72 8 O’Roak O’Roak NNP work_rdyppa4isra3dorthbk5454hem 72 9 BJ BJ NNP work_rdyppa4isra3dorthbk5454hem 72 10 et et NNP work_rdyppa4isra3dorthbk5454hem 72 11 al al NNP work_rdyppa4isra3dorthbk5454hem 72 12 : : : work_rdyppa4isra3dorthbk5454hem 72 13 Sequence sequence NN work_rdyppa4isra3dorthbk5454hem 72 14 variants variant NNS work_rdyppa4isra3dorthbk5454hem 72 15 in in IN work_rdyppa4isra3dorthbk5454hem 72 16 SLITRK1 SLITRK1 NNS work_rdyppa4isra3dorthbk5454hem 72 17 are be VBP work_rdyppa4isra3dorthbk5454hem 72 18 associated associate VBN work_rdyppa4isra3dorthbk5454hem 72 19 with with IN work_rdyppa4isra3dorthbk5454hem 72 20 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 72 21 ’s ’s POS work_rdyppa4isra3dorthbk5454hem 72 22 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 72 23 . . . work_rdyppa4isra3dorthbk5454hem 73 1 Science science NN work_rdyppa4isra3dorthbk5454hem 73 2 2005 2005 CD work_rdyppa4isra3dorthbk5454hem 73 3 ; ; : work_rdyppa4isra3dorthbk5454hem 73 4 310 310 CD work_rdyppa4isra3dorthbk5454hem 73 5 : : : work_rdyppa4isra3dorthbk5454hem 73 6 317–320 317–320 CD work_rdyppa4isra3dorthbk5454hem 73 7 . . . work_rdyppa4isra3dorthbk5454hem 74 1 10 10 CD work_rdyppa4isra3dorthbk5454hem 74 2 Kirchhoff Kirchhoff NNP work_rdyppa4isra3dorthbk5454hem 74 3 M M NNP work_rdyppa4isra3dorthbk5454hem 74 4 , , , work_rdyppa4isra3dorthbk5454hem 74 5 Gerdes Gerdes NNP work_rdyppa4isra3dorthbk5454hem 74 6 T T NNP work_rdyppa4isra3dorthbk5454hem 74 7 , , , work_rdyppa4isra3dorthbk5454hem 74 8 Rose Rose NNP work_rdyppa4isra3dorthbk5454hem 74 9 H H NNP work_rdyppa4isra3dorthbk5454hem 74 10 , , , work_rdyppa4isra3dorthbk5454hem 74 11 Maahr Maahr NNP work_rdyppa4isra3dorthbk5454hem 74 12 J J NNP work_rdyppa4isra3dorthbk5454hem 74 13 , , , work_rdyppa4isra3dorthbk5454hem 74 14 Ottesen Ottesen NNP work_rdyppa4isra3dorthbk5454hem 74 15 AM AM NNP work_rdyppa4isra3dorthbk5454hem 74 16 , , , work_rdyppa4isra3dorthbk5454hem 74 17 Lundsteen Lundsteen NNP work_rdyppa4isra3dorthbk5454hem 74 18 C C NNP work_rdyppa4isra3dorthbk5454hem 74 19 : : : work_rdyppa4isra3dorthbk5454hem 74 20 Detection detection NN work_rdyppa4isra3dorthbk5454hem 74 21 of of IN work_rdyppa4isra3dorthbk5454hem 74 22 chromosomal chromosomal JJ work_rdyppa4isra3dorthbk5454hem 74 23 gains gain NNS work_rdyppa4isra3dorthbk5454hem 74 24 and and CC work_rdyppa4isra3dorthbk5454hem 74 25 losses loss NNS work_rdyppa4isra3dorthbk5454hem 74 26 in in IN work_rdyppa4isra3dorthbk5454hem 74 27 comparative comparative JJ work_rdyppa4isra3dorthbk5454hem 74 28 genomic genomic JJ work_rdyppa4isra3dorthbk5454hem 74 29 hybridization hybridization NNP work_rdyppa4isra3dorthbk5454hem 74 30 analysis analysis NN work_rdyppa4isra3dorthbk5454hem 74 31 based base VBN work_rdyppa4isra3dorthbk5454hem 74 32 on on IN work_rdyppa4isra3dorthbk5454hem 74 33 standard standard JJ work_rdyppa4isra3dorthbk5454hem 74 34 reference reference NN work_rdyppa4isra3dorthbk5454hem 74 35 intervals interval NNS work_rdyppa4isra3dorthbk5454hem 74 36 . . . work_rdyppa4isra3dorthbk5454hem 75 1 Cytometry cytometry NN work_rdyppa4isra3dorthbk5454hem 75 2 1998 1998 CD work_rdyppa4isra3dorthbk5454hem 75 3 ; ; : work_rdyppa4isra3dorthbk5454hem 75 4 31 31 CD work_rdyppa4isra3dorthbk5454hem 75 5 : : SYM work_rdyppa4isra3dorthbk5454hem 75 6 163–173 163–173 CD work_rdyppa4isra3dorthbk5454hem 75 7 . . . work_rdyppa4isra3dorthbk5454hem 76 1 11 11 CD work_rdyppa4isra3dorthbk5454hem 76 2 Bache Bache NNP work_rdyppa4isra3dorthbk5454hem 76 3 I I NNP work_rdyppa4isra3dorthbk5454hem 76 4 , , , work_rdyppa4isra3dorthbk5454hem 76 5 Hjorth Hjorth NNP work_rdyppa4isra3dorthbk5454hem 76 6 M M NNP work_rdyppa4isra3dorthbk5454hem 76 7 , , , work_rdyppa4isra3dorthbk5454hem 76 8 Bugge Bugge NNP work_rdyppa4isra3dorthbk5454hem 76 9 M M NNP work_rdyppa4isra3dorthbk5454hem 76 10 et et NN work_rdyppa4isra3dorthbk5454hem 76 11 al al NNP work_rdyppa4isra3dorthbk5454hem 76 12 : : : work_rdyppa4isra3dorthbk5454hem 76 13 Systematic systematic JJ work_rdyppa4isra3dorthbk5454hem 76 14 re re NN work_rdyppa4isra3dorthbk5454hem 76 15 - - NN work_rdyppa4isra3dorthbk5454hem 76 16 examination examination NN work_rdyppa4isra3dorthbk5454hem 76 17 of of IN work_rdyppa4isra3dorthbk5454hem 76 18 carriers carrier NNS work_rdyppa4isra3dorthbk5454hem 76 19 of of IN work_rdyppa4isra3dorthbk5454hem 76 20 balanced balance VBN work_rdyppa4isra3dorthbk5454hem 76 21 reciprocal reciprocal JJ work_rdyppa4isra3dorthbk5454hem 76 22 translocations translocation NNS work_rdyppa4isra3dorthbk5454hem 76 23 : : : work_rdyppa4isra3dorthbk5454hem 76 24 a a DT work_rdyppa4isra3dorthbk5454hem 76 25 strategy strategy NN work_rdyppa4isra3dorthbk5454hem 76 26 to to TO work_rdyppa4isra3dorthbk5454hem 76 27 search search VB work_rdyppa4isra3dorthbk5454hem 76 28 for for IN work_rdyppa4isra3dorthbk5454hem 76 29 candidate candidate NN work_rdyppa4isra3dorthbk5454hem 76 30 regions region NNS work_rdyppa4isra3dorthbk5454hem 76 31 for for IN work_rdyppa4isra3dorthbk5454hem 76 32 common common JJ work_rdyppa4isra3dorthbk5454hem 76 33 and and CC work_rdyppa4isra3dorthbk5454hem 76 34 complex complex JJ work_rdyppa4isra3dorthbk5454hem 76 35 diseases disease NNS work_rdyppa4isra3dorthbk5454hem 76 36 . . . work_rdyppa4isra3dorthbk5454hem 77 1 Eur Eur NNP work_rdyppa4isra3dorthbk5454hem 77 2 J J NNP work_rdyppa4isra3dorthbk5454hem 77 3 Hum Hum NNP work_rdyppa4isra3dorthbk5454hem 77 4 Genet Genet NNP work_rdyppa4isra3dorthbk5454hem 77 5 2006 2006 CD work_rdyppa4isra3dorthbk5454hem 77 6 ; ; : work_rdyppa4isra3dorthbk5454hem 77 7 14 14 CD work_rdyppa4isra3dorthbk5454hem 77 8 : : : work_rdyppa4isra3dorthbk5454hem 77 9 410–417 410–417 CD work_rdyppa4isra3dorthbk5454hem 77 10 . . . work_rdyppa4isra3dorthbk5454hem 78 1 Truncation truncation NN work_rdyppa4isra3dorthbk5454hem 78 2 of of IN work_rdyppa4isra3dorthbk5454hem 78 3 CNTNAP2 CNTNAP2 NNS work_rdyppa4isra3dorthbk5454hem 78 4 without without IN work_rdyppa4isra3dorthbk5454hem 78 5 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 78 6 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 78 7 JM JM NNP work_rdyppa4isra3dorthbk5454hem 78 8 Belloso Belloso NNP work_rdyppa4isra3dorthbk5454hem 78 9 et et NNP work_rdyppa4isra3dorthbk5454hem 78 10 al al NNP work_rdyppa4isra3dorthbk5454hem 78 11 713 713 CD work_rdyppa4isra3dorthbk5454hem 78 12 European European NNP work_rdyppa4isra3dorthbk5454hem 78 13 Journal Journal NNP work_rdyppa4isra3dorthbk5454hem 78 14 of of IN work_rdyppa4isra3dorthbk5454hem 78 15 Human Human NNP work_rdyppa4isra3dorthbk5454hem 78 16 Genetics Genetics NNP work_rdyppa4isra3dorthbk5454hem 78 17 Disruption Disruption NNP work_rdyppa4isra3dorthbk5454hem 78 18 of of IN work_rdyppa4isra3dorthbk5454hem 78 19 the the DT work_rdyppa4isra3dorthbk5454hem 78 20 CNTNAP2 CNTNAP2 NNP work_rdyppa4isra3dorthbk5454hem 78 21 gene gene NN work_rdyppa4isra3dorthbk5454hem 78 22 in in IN work_rdyppa4isra3dorthbk5454hem 78 23 a a DT work_rdyppa4isra3dorthbk5454hem 78 24 t(7;15 t(7;15 NN work_rdyppa4isra3dorthbk5454hem 78 25 ) ) -RRB- work_rdyppa4isra3dorthbk5454hem 78 26 translocation translocation NN work_rdyppa4isra3dorthbk5454hem 78 27 family family NN work_rdyppa4isra3dorthbk5454hem 78 28 without without IN work_rdyppa4isra3dorthbk5454hem 78 29 symptoms symptom NNS work_rdyppa4isra3dorthbk5454hem 78 30 of of IN work_rdyppa4isra3dorthbk5454hem 78 31 Gilles Gilles NNP work_rdyppa4isra3dorthbk5454hem 78 32 de de FW work_rdyppa4isra3dorthbk5454hem 78 33 la la NNP work_rdyppa4isra3dorthbk5454hem 78 34 Tourette Tourette NNP work_rdyppa4isra3dorthbk5454hem 78 35 syndrome syndrome NN work_rdyppa4isra3dorthbk5454hem 78 36 Introduction introduction NN work_rdyppa4isra3dorthbk5454hem 78 37 Materials material NNS work_rdyppa4isra3dorthbk5454hem 78 38 and and CC work_rdyppa4isra3dorthbk5454hem 78 39 methods method NNS work_rdyppa4isra3dorthbk5454hem 78 40 Cytogenetic cytogenetic JJ work_rdyppa4isra3dorthbk5454hem 78 41 analyses analysis NNS work_rdyppa4isra3dorthbk5454hem 78 42 , , , work_rdyppa4isra3dorthbk5454hem 78 43 FISH fish NN work_rdyppa4isra3dorthbk5454hem 78 44 and and CC work_rdyppa4isra3dorthbk5454hem 78 45 CGH CGH NNP work_rdyppa4isra3dorthbk5454hem 78 46 Results Results NNPS work_rdyppa4isra3dorthbk5454hem 78 47 and and CC work_rdyppa4isra3dorthbk5454hem 78 48 discussion discussion NN work_rdyppa4isra3dorthbk5454hem 78 49 Acknowledgements acknowledgement NNS work_rdyppa4isra3dorthbk5454hem 78 50 Note note VBP work_rdyppa4isra3dorthbk5454hem 78 51 References reference NNS