id sid tid token lemma pos work_gukk34cj2ba2hfeeqnbcodfs6m 1 1 ARTICLE ARTICLE NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 2 Worldwide Worldwide NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 3 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 4 spectrum spectrum NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 5 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 6 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 7 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 1 8 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 9 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 10 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 1 11 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 1 12 founder founder NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 13 origin origin NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 14 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 1 16 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 1 17 70A?G 70a?g CD work_gukk34cj2ba2hfeeqnbcodfs6m 1 18 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 19 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 1 21 untranslated untranslated JJ work_gukk34cj2ba2hfeeqnbcodfs6m 1 22 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 23 Maaret Maaret NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 24 Ridanpää1,2 Ridanpää1,2 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 25 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 26 Pertti Pertti NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 27 Sistonen3 Sistonen3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 28 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 29 Susanna Susanna NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 30 Rockas1,2 rockas1,2 CD work_gukk34cj2ba2hfeeqnbcodfs6m 1 31 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 32 David David NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 33 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 34 Rimoin4 Rimoin4 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 35 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 36 Outi Outi NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 37 Mäkitie5 Mäkitie5 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 38 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 1 39 Ilkka Ilkka NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 40 Kaitila*,2,6 Kaitila*,2,6 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 41 1Folkhälsan 1folkhälsan CD work_gukk34cj2ba2hfeeqnbcodfs6m 1 42 Institute Institute NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 43 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 44 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 45 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 46 Biomedicum Biomedicum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 47 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 48 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 49 FI-00014 FI-00014 NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 1 50 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 51 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 52 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 53 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 54 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 55 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 1 56 2Department 2department CD work_gukk34cj2ba2hfeeqnbcodfs6m 1 57 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 58 Medical Medical NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 59 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 60 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 61 Biomedicum Biomedicum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 62 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 63 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 64 FI-00014 FI-00014 NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 1 65 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 66 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 67 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 68 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 69 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 70 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 1 71 3Finnish 3Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 72 Red Red NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 73 Cross Cross NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 74 Blood Blood NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 75 Transfusion Transfusion NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 76 Service Service NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 77 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 78 FI-00310 FI-00310 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 79 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 80 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 81 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 82 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 1 83 4Cedar 4Cedar NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 84 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 1 85 Sinai Sinai NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 86 Medical Medical NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 87 Center Center NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 88 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 89 Los Los NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 90 Angeles Angeles NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 91 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 92 California California NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 93 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 94 CA CA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 95 90048 90048 CD work_gukk34cj2ba2hfeeqnbcodfs6m 1 96 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 97 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 98 ; ; , work_gukk34cj2ba2hfeeqnbcodfs6m 1 99 5Hospital 5hospital JJ work_gukk34cj2ba2hfeeqnbcodfs6m 1 100 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 101 Children Children NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 1 102 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 1 103 Adolescents Adolescents NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 1 104 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 105 FI-00029 FI-00029 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 106 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 107 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 108 Central Central NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 109 Hospital Hospital NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 110 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 111 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 112 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 1 113 6Department 6Department NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 114 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 115 Clinical Clinical NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 116 Genetics Genetics NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 1 117 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 118 FI-00029 FI-00029 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 119 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 120 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 121 Central Central NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 122 Hospital Hospital NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 123 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 124 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 125 Pleiotropic Pleiotropic NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 126 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 1 127 recessively recessively RB work_gukk34cj2ba2hfeeqnbcodfs6m 1 128 inherited inherit VBD work_gukk34cj2ba2hfeeqnbcodfs6m 1 129 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 130 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 1 131 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 132 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 133 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 1 134 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 135 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 1 136 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 1 137 due due JJ work_gukk34cj2ba2hfeeqnbcodfs6m 1 138 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 139 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 1 140 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 141 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 1 142 untranslated untranslated JJ work_gukk34cj2ba2hfeeqnbcodfs6m 1 143 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 144 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 145 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 146 chromosome chromosome NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 147 9p13-p12 9p13-p12 JJ work_gukk34cj2ba2hfeeqnbcodfs6m 1 148 encoding encode VBG work_gukk34cj2ba2hfeeqnbcodfs6m 1 149 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 1 150 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 151 component component NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 152 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 1 153 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 154 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 1 155 endoribonuclease endoribonuclease NN work_gukk34cj2ba2hfeeqnbcodfs6m 1 156 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 2 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 2 2 describe describe VBP work_gukk34cj2ba2hfeeqnbcodfs6m 2 3 36 36 CD work_gukk34cj2ba2hfeeqnbcodfs6m 2 4 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 2 5 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 2 6 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 2 7 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 2 8 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 2 9 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 2 10 91 91 CD work_gukk34cj2ba2hfeeqnbcodfs6m 2 11 Finnish Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 2 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 2 13 44 44 CD work_gukk34cj2ba2hfeeqnbcodfs6m 2 14 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 2 15 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 2 16 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 2 17 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 2 18 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 2 19 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 3 1 Based base VBN work_gukk34cj2ba2hfeeqnbcodfs6m 3 2 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 3 3 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 3 4 nature nature NN work_gukk34cj2ba2hfeeqnbcodfs6m 3 5 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 3 6 localisation localisation NN work_gukk34cj2ba2hfeeqnbcodfs6m 3 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 3 8 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 3 9 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 3 10 can can MD work_gukk34cj2ba2hfeeqnbcodfs6m 3 11 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 3 12 classified classify VBN work_gukk34cj2ba2hfeeqnbcodfs6m 3 13 into into IN work_gukk34cj2ba2hfeeqnbcodfs6m 3 14 three three CD work_gukk34cj2ba2hfeeqnbcodfs6m 3 15 categories category NNS work_gukk34cj2ba2hfeeqnbcodfs6m 3 16 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 3 17 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 3 18 affecting affect VBG work_gukk34cj2ba2hfeeqnbcodfs6m 3 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 3 20 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 3 21 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 3 22 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 3 23 small small JJ work_gukk34cj2ba2hfeeqnbcodfs6m 3 24 changes change NNS work_gukk34cj2ba2hfeeqnbcodfs6m 3 25 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 3 26 conserved conserved JJ work_gukk34cj2ba2hfeeqnbcodfs6m 3 27 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 3 28 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 3 29 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 3 30 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 3 31 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 3 32 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 3 33 insertions insertion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 3 34 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 3 35 duplications duplication NNS work_gukk34cj2ba2hfeeqnbcodfs6m 3 36 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 3 37 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 3 38 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 3 39 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 3 40 end end NN work_gukk34cj2ba2hfeeqnbcodfs6m 3 41 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 3 42 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 3 43 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 3 44 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 4 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 4 2 only only JJ work_gukk34cj2ba2hfeeqnbcodfs6m 4 3 known know VBN work_gukk34cj2ba2hfeeqnbcodfs6m 4 4 functional functional JJ work_gukk34cj2ba2hfeeqnbcodfs6m 4 5 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 4 6 that that WDT work_gukk34cj2ba2hfeeqnbcodfs6m 4 7 seemed seem VBD work_gukk34cj2ba2hfeeqnbcodfs6m 4 8 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 4 9 avoid avoid VB work_gukk34cj2ba2hfeeqnbcodfs6m 4 10 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 4 11 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 4 12 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 4 13 nucleolar nucleolar JJ work_gukk34cj2ba2hfeeqnbcodfs6m 4 14 localisation localisation NN work_gukk34cj2ba2hfeeqnbcodfs6m 4 15 signal signal NN work_gukk34cj2ba2hfeeqnbcodfs6m 4 16 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 4 17 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 4 18 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 4 19 23 23 CD work_gukk34cj2ba2hfeeqnbcodfs6m 4 20 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 4 21 62 62 CD work_gukk34cj2ba2hfeeqnbcodfs6m 4 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 5 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 5 2 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 5 3 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 5 4 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 5 5 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 5 6 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 5 7 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 5 8 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 5 9 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 5 10 base base JJ work_gukk34cj2ba2hfeeqnbcodfs6m 5 11 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 5 12 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 5 13 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 5 14 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 5 15 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 5 16 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 5 17 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 5 18 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 6 1 This this DT work_gukk34cj2ba2hfeeqnbcodfs6m 6 2 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 6 3 contributed contribute VBD work_gukk34cj2ba2hfeeqnbcodfs6m 6 4 92 92 CD work_gukk34cj2ba2hfeeqnbcodfs6m 6 5 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 6 6 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 6 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 6 8 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 6 9 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 6 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 6 11 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 6 12 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 6 13 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 6 14 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 7 1 Our -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 7 2 results result NNS work_gukk34cj2ba2hfeeqnbcodfs6m 7 3 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 7 4 linkage linkage NN work_gukk34cj2ba2hfeeqnbcodfs6m 7 5 disequilibrium disequilibrium NN work_gukk34cj2ba2hfeeqnbcodfs6m 7 6 based base VBN work_gukk34cj2ba2hfeeqnbcodfs6m 7 7 maximum maximum JJ work_gukk34cj2ba2hfeeqnbcodfs6m 7 8 likelihood likelihood NN work_gukk34cj2ba2hfeeqnbcodfs6m 7 9 estimates estimate VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 7 10 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 7 11 close close JJ work_gukk34cj2ba2hfeeqnbcodfs6m 7 12 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 7 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 7 14 genealogical genealogical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 7 15 studies study NNS work_gukk34cj2ba2hfeeqnbcodfs6m 7 16 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 7 17 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 7 18 haplotype haplotype NNP work_gukk34cj2ba2hfeeqnbcodfs6m 7 19 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 7 20 suggested suggest VBD work_gukk34cj2ba2hfeeqnbcodfs6m 7 21 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 7 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 7 23 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 7 24 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 7 25 introduced introduce VBN work_gukk34cj2ba2hfeeqnbcodfs6m 7 26 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 7 27 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 7 28 some some DT work_gukk34cj2ba2hfeeqnbcodfs6m 7 29 3900 3900 CD work_gukk34cj2ba2hfeeqnbcodfs6m 7 30 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 7 31 4800 4800 CD work_gukk34cj2ba2hfeeqnbcodfs6m 7 32 years year NNS work_gukk34cj2ba2hfeeqnbcodfs6m 7 33 ago ago RB work_gukk34cj2ba2hfeeqnbcodfs6m 7 34 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 7 35 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 7 36 before before IN work_gukk34cj2ba2hfeeqnbcodfs6m 7 37 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 7 38 expansion expansion NN work_gukk34cj2ba2hfeeqnbcodfs6m 7 39 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 7 40 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 7 41 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 7 42 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 8 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 8 2 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 8 3 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 8 4 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 8 5 accounted account VBD work_gukk34cj2ba2hfeeqnbcodfs6m 8 6 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 8 7 48 48 CD work_gukk34cj2ba2hfeeqnbcodfs6m 8 8 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 8 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 8 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 8 11 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 8 12 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 8 13 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 14 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 8 15 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 8 16 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 8 17 parts part NNS work_gukk34cj2ba2hfeeqnbcodfs6m 8 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 8 19 Europe Europe NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 8 21 North North NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 8 23 South South NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 24 America America NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 25 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 8 26 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 8 27 Near Near NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 28 East East NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 29 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 8 30 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 8 31 Australia Australia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 8 32 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 9 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 9 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 9 3 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 9 4 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 9 5 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 9 6 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 9 7 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 9 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 9 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 9 10 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 9 11 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 9 12 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 9 13 segregated segregate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 9 14 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 9 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 9 16 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 9 17 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 9 18 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 9 19 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 9 20 although although IN work_gukk34cj2ba2hfeeqnbcodfs6m 9 21 shorter short JJR work_gukk34cj2ba2hfeeqnbcodfs6m 9 22 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 9 23 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 9 24 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 9 25 most most JJS work_gukk34cj2ba2hfeeqnbcodfs6m 9 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 9 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 9 28 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 9 29 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 9 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 10 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 10 2 23 23 CD work_gukk34cj2ba2hfeeqnbcodfs6m 10 3 out out IN work_gukk34cj2ba2hfeeqnbcodfs6m 10 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 10 5 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 10 6 27 27 CD work_gukk34cj2ba2hfeeqnbcodfs6m 10 7 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 10 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 10 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 10 10 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 10 11 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 10 12 extended extend VBN work_gukk34cj2ba2hfeeqnbcodfs6m 10 13 over over IN work_gukk34cj2ba2hfeeqnbcodfs6m 10 14 60 60 CD work_gukk34cj2ba2hfeeqnbcodfs6m 10 15 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 10 16 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 10 17 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 10 18 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 10 19 therefore therefore RB work_gukk34cj2ba2hfeeqnbcodfs6m 10 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 10 21 all all PDT work_gukk34cj2ba2hfeeqnbcodfs6m 10 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 10 23 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 10 24 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 10 25 likely likely RB work_gukk34cj2ba2hfeeqnbcodfs6m 10 26 arose arise VBD work_gukk34cj2ba2hfeeqnbcodfs6m 10 27 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 10 28 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 10 29 solitary solitary JJ work_gukk34cj2ba2hfeeqnbcodfs6m 10 30 event event NN work_gukk34cj2ba2hfeeqnbcodfs6m 10 31 many many JJ work_gukk34cj2ba2hfeeqnbcodfs6m 10 32 thousands thousand NNS work_gukk34cj2ba2hfeeqnbcodfs6m 10 33 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 10 34 years year NNS work_gukk34cj2ba2hfeeqnbcodfs6m 10 35 ago ago RB work_gukk34cj2ba2hfeeqnbcodfs6m 10 36 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 11 1 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 2 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 11 4 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 5 Genetics Genetics NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 11 6 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 11 7 2002 2002 CD work_gukk34cj2ba2hfeeqnbcodfs6m 11 8 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 11 9 10 10 CD work_gukk34cj2ba2hfeeqnbcodfs6m 11 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 11 11 439 439 CD work_gukk34cj2ba2hfeeqnbcodfs6m 11 12 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 11 13 447 447 CD work_gukk34cj2ba2hfeeqnbcodfs6m 11 14 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 11 15 doi:10.1038 doi:10.1038 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 16 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 11 17 sj.ejhg.5200824 sj.ejhg.5200824 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 18 Keywords Keywords NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 11 19 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 11 20 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 21 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 11 22 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 23 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 11 24 ancestral ancestral JJ work_gukk34cj2ba2hfeeqnbcodfs6m 11 25 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 26 ; ; , work_gukk34cj2ba2hfeeqnbcodfs6m 11 27 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 28 estimation estimation NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 29 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 11 30 untranslated untranslated JJ work_gukk34cj2ba2hfeeqnbcodfs6m 11 31 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 32 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 11 33 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 34 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 11 35 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 36 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 37 Introduction Introduction NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 38 Cartilage Cartilage NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 39 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 11 40 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 41 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 42 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 11 43 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 44 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 11 45 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 11 46 McKusick McKusick NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 47 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 11 48 type type NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 49 meta- meta- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 50 physeal physeal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 51 chondrodysplasia chondrodysplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 52 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 11 53 MIM MIM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 11 54 250250 250250 CD work_gukk34cj2ba2hfeeqnbcodfs6m 11 55 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 11 56 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 11 57 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 11 58 pleiotropic pleiotropic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 11 59 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 60 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 11 61 characterised characterise VBN work_gukk34cj2ba2hfeeqnbcodfs6m 11 62 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 11 63 disproportionate disproportionate JJ work_gukk34cj2ba2hfeeqnbcodfs6m 11 64 short short JJ work_gukk34cj2ba2hfeeqnbcodfs6m 11 65 stature stature NN work_gukk34cj2ba2hfeeqnbcodfs6m 11 66 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 12 1 Other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 12 2 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 12 3 features feature NNS work_gukk34cj2ba2hfeeqnbcodfs6m 12 4 include include VBP work_gukk34cj2ba2hfeeqnbcodfs6m 12 5 hypoplastic hypoplastic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 12 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 12 8 defective defective JJ work_gukk34cj2ba2hfeeqnbcodfs6m 12 9 immunity immunity NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 12 11 risk risk NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 12 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 12 13 malignancies malignancy NNS work_gukk34cj2ba2hfeeqnbcodfs6m 12 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 12 15 Hirschsprung Hirschsprung NNP work_gukk34cj2ba2hfeeqnbcodfs6m 12 16 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 17 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 12 18 hypoplastic hypoplastic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 12 19 anaemia anaemia NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 12 21 impaired impair VBN work_gukk34cj2ba2hfeeqnbcodfs6m 12 22 spermatogenesis spermatogenesis NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 23 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 12 24 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 12 25 increased increase VBD work_gukk34cj2ba2hfeeqnbcodfs6m 12 26 mortality.1 mortality.1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 12 27 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 12 28 6 6 CD work_gukk34cj2ba2hfeeqnbcodfs6m 12 29 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 12 30 variation variation NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 31 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 12 32 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 12 33 clinical clinical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 12 34 severity severity NN work_gukk34cj2ba2hfeeqnbcodfs6m 12 35 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 12 36 remarkable remarkable JJ work_gukk34cj2ba2hfeeqnbcodfs6m 12 37 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 12 38 even even RB work_gukk34cj2ba2hfeeqnbcodfs6m 12 39 within within IN work_gukk34cj2ba2hfeeqnbcodfs6m 12 40 affected affect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 12 41 siblings sibling NNS work_gukk34cj2ba2hfeeqnbcodfs6m 12 42 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 13 1 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 2 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 13 3 espe- espe- NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 4 cially cially RB work_gukk34cj2ba2hfeeqnbcodfs6m 13 5 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 13 6 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 13 8 Old Old NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 9 Order Order NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 10 Amish Amish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 11 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 12 North North NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 13 America America NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 14 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 13 15 Finns.1,2 Finns.1,2 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 16 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 13 17 carrier carrier NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 18 frequencies frequencie VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 13 19 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 13 21 Amish Amish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 13 23 Finns Finns NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 13 24 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 13 25 calculated calculate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 13 26 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 13 27 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 13 28 as as RB work_gukk34cj2ba2hfeeqnbcodfs6m 13 29 high high JJ work_gukk34cj2ba2hfeeqnbcodfs6m 13 30 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 31 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 32 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 13 33 19 19 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 34 Received receive VBD work_gukk34cj2ba2hfeeqnbcodfs6m 13 35 11 11 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 36 February February NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 37 2002 2002 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 38 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 13 39 revised revise VBN work_gukk34cj2ba2hfeeqnbcodfs6m 13 40 25 25 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 41 March March NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 42 2002 2002 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 43 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 13 44 accepted accept VBD work_gukk34cj2ba2hfeeqnbcodfs6m 13 45 17 17 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 46 April April NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 47 2002 2002 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 48 * * NFP work_gukk34cj2ba2hfeeqnbcodfs6m 13 49 Correspondence correspondence NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 50 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 13 51 I -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 13 52 Kaitila kaitila VBP work_gukk34cj2ba2hfeeqnbcodfs6m 13 53 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 13 54 Department Department NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 55 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 56 Clinical Clinical NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 57 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 58 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 13 59 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 60 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 61 Central Central NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 62 Hospital Hospital NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 63 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 13 64 F1 F1 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 65 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 13 66 00029 00029 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 67 HUS HUS NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 68 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 13 69 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 70 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 13 71 Tel tel NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 72 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 13 73 +358 +358 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 74 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 75 9 9 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 76 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 77 47172186 47172186 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 78 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 13 79 Fax fax NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 80 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 13 81 +358 +358 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 82 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 83 9 9 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 84 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 85 47176089 47176089 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 86 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 13 87 E e NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 88 - - NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 89 mail mail NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 90 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 13 91 ilkka.kaitila@hus.fi ilkka.kaitila@hus.fi NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 92 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 93 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 94 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 95 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 96 Genetics Genetics NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 13 97 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 98 2002 2002 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 99 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 100 10 10 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 101 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 13 102 439 439 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 103 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 13 104 447 447 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 105 ª ª NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 106 2002 2002 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 107 Nature Nature NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 108 Publishing Publishing NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 109 Group Group NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 110 All All NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 111 rights right NNS work_gukk34cj2ba2hfeeqnbcodfs6m 13 112 reserved reserve VBD work_gukk34cj2ba2hfeeqnbcodfs6m 13 113 1018 1018 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 114 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 13 115 4813/02 4813/02 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 116 $ $ $ work_gukk34cj2ba2hfeeqnbcodfs6m 13 117 25.00 25.00 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 118 www.nature.com/ejhg www.nature.com/ejhg NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 119 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 13 120 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 121 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 13 122 76 76 CD work_gukk34cj2ba2hfeeqnbcodfs6m 13 123 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 13 124 respectively.2,7 respectively.2,7 CC work_gukk34cj2ba2hfeeqnbcodfs6m 13 125 There there EX work_gukk34cj2ba2hfeeqnbcodfs6m 13 126 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 13 127 no no DT work_gukk34cj2ba2hfeeqnbcodfs6m 13 128 precise precise JJ work_gukk34cj2ba2hfeeqnbcodfs6m 13 129 measure measure NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 130 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 131 worldwide worldwide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 13 132 incidence incidence NN work_gukk34cj2ba2hfeeqnbcodfs6m 13 133 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 13 134 although although IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 135 cases case NNS work_gukk34cj2ba2hfeeqnbcodfs6m 13 136 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 13 137 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 13 138 observed observe VBN work_gukk34cj2ba2hfeeqnbcodfs6m 13 139 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 13 140 numerous numerous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 13 141 populations population NNS work_gukk34cj2ba2hfeeqnbcodfs6m 13 142 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 143 International International NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 144 Skeletal Skeletal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 145 Dysplasia Dysplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 146 Registry Registry NNP work_gukk34cj2ba2hfeeqnbcodfs6m 13 147 ; ; , work_gukk34cj2ba2hfeeqnbcodfs6m 13 148 personal personal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 13 149 observations observation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 13 150 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 13 151 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 14 1 After after IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 2 initial initial JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 3 mapping mapping NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 6 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 7 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 8 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 9 9p13,8 9p13,8 CD work_gukk34cj2ba2hfeeqnbcodfs6m 14 10 linkage linkage NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 11 disequilibrium disequilibrium NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 12 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 14 13 detected detect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 14 14 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 15 Amish Amish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 16 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 14 17 Finns.7,9 Finns.7,9 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 18 Based base VBN work_gukk34cj2ba2hfeeqnbcodfs6m 14 19 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 21 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 22 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 23 history history NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 24 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 14 25 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 26 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 14 27 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 14 28 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 14 29 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 14 30 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 31 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 14 32 suggested suggest VBN work_gukk34cj2ba2hfeeqnbcodfs6m 14 33 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 14 34 account account VB work_gukk34cj2ba2hfeeqnbcodfs6m 14 35 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 36 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 37 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 38 cases,1,7 cases,1,7 UH work_gukk34cj2ba2hfeeqnbcodfs6m 14 39 but but CC work_gukk34cj2ba2hfeeqnbcodfs6m 14 40 recently recently RB work_gukk34cj2ba2hfeeqnbcodfs6m 14 41 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 14 42 multiple multiple JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 43 allelic allelic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 44 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 14 45 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 14 46 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 14 47 accepted accept VBN work_gukk34cj2ba2hfeeqnbcodfs6m 14 48 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 49 being be VBG work_gukk34cj2ba2hfeeqnbcodfs6m 14 50 possible.10 possible.10 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 51 Among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 52 Finns Finns NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 53 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 14 54 85 85 CD work_gukk34cj2ba2hfeeqnbcodfs6m 14 55 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 14 56 95 95 CD work_gukk34cj2ba2hfeeqnbcodfs6m 14 57 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 58 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 59 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 60 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 61 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 14 62 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 14 63 estimated estimate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 14 64 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 14 65 originate originate VB work_gukk34cj2ba2hfeeqnbcodfs6m 14 66 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 67 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 68 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 69 ancestor ancestor NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 70 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 14 71 contain contain VB work_gukk34cj2ba2hfeeqnbcodfs6m 14 72 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 73 identical identical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 74 mutation.9 mutation.9 CD work_gukk34cj2ba2hfeeqnbcodfs6m 14 75 As as IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 76 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 77 result result NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 78 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 79 several several JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 80 years year NNS work_gukk34cj2ba2hfeeqnbcodfs6m 14 81 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 82 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 83 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 14 84 physical physical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 85 mapping,11 mapping,11 NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 86 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 87 first first JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 88 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 89 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 14 90 causing cause VBG work_gukk34cj2ba2hfeeqnbcodfs6m 14 91 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 14 92 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 93 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 94 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 14 95 described.12 described.12 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 96 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 97 untranslated untranslated JJ work_gukk34cj2ba2hfeeqnbcodfs6m 14 98 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 99 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 100 encodes encode VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 14 101 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 102 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 103 component component NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 104 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 14 105 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 14 106 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 107 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 14 108 complex complex NN work_gukk34cj2ba2hfeeqnbcodfs6m 14 109 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 15 1 Normally normally RB work_gukk34cj2ba2hfeeqnbcodfs6m 15 2 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 15 3 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 15 4 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 5 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 6 complex complex NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 7 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 15 8 involved involve VBN work_gukk34cj2ba2hfeeqnbcodfs6m 15 9 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 10 multiple multiple JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 11 cellular cellular JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 15 13 mitochondrial mitochondrial JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 14 functions function NNS work_gukk34cj2ba2hfeeqnbcodfs6m 15 15 though though IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 15 17 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 18 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 15 19 causing cause VBG work_gukk34cj2ba2hfeeqnbcodfs6m 15 20 func- func- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 21 tional tional JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 22 impairment impairment NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 15 25 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 26 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 27 product product NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 28 remains remain VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 15 29 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 15 30 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 15 31 characterised.12,13 characterised.12,13 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 32 Cartilage Cartilage NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 33 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 15 34 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 35 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 36 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 15 37 counted count VBN work_gukk34cj2ba2hfeeqnbcodfs6m 15 38 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 39 being be VBG work_gukk34cj2ba2hfeeqnbcodfs6m 15 40 part part NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 41 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 42 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 15 43 so so RB work_gukk34cj2ba2hfeeqnbcodfs6m 15 44 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 15 45 called call VBN work_gukk34cj2ba2hfeeqnbcodfs6m 15 46 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 47 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 48 heritage heritage NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 49 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 15 50 which which WDT work_gukk34cj2ba2hfeeqnbcodfs6m 15 51 consists consist VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 15 52 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 53 some some DT work_gukk34cj2ba2hfeeqnbcodfs6m 15 54 thirty thirty CD work_gukk34cj2ba2hfeeqnbcodfs6m 15 55 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 56 diseases disease NNS work_gukk34cj2ba2hfeeqnbcodfs6m 15 57 enriched enrich VBN work_gukk34cj2ba2hfeeqnbcodfs6m 15 58 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 59 Finland14 Finland14 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 60 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 15 61 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 15 62 its -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 15 63 origin origin NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 64 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 65 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 15 66 special special JJ work_gukk34cj2ba2hfeeqnbcodfs6m 15 67 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 68 history history NN work_gukk34cj2ba2hfeeqnbcodfs6m 15 69 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 15 70 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 15 71 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 16 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 2 current current JJ work_gukk34cj2ba2hfeeqnbcodfs6m 16 3 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 16 4 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 16 5 thought think VBN work_gukk34cj2ba2hfeeqnbcodfs6m 16 6 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 16 7 have have VB work_gukk34cj2ba2hfeeqnbcodfs6m 16 8 originated originate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 16 9 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 16 10 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 11 relatively relatively RB work_gukk34cj2ba2hfeeqnbcodfs6m 16 12 small small JJ work_gukk34cj2ba2hfeeqnbcodfs6m 16 13 founding found VBG work_gukk34cj2ba2hfeeqnbcodfs6m 16 14 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 16 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 16 16 very very RB work_gukk34cj2ba2hfeeqnbcodfs6m 16 17 little little JJ work_gukk34cj2ba2hfeeqnbcodfs6m 16 18 immi- immi- NN work_gukk34cj2ba2hfeeqnbcodfs6m 16 19 gration gration NN work_gukk34cj2ba2hfeeqnbcodfs6m 16 20 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 16 21 occurred occur VBN work_gukk34cj2ba2hfeeqnbcodfs6m 16 22 during during IN work_gukk34cj2ba2hfeeqnbcodfs6m 16 23 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 24 last last JJ work_gukk34cj2ba2hfeeqnbcodfs6m 16 25 80 80 CD work_gukk34cj2ba2hfeeqnbcodfs6m 16 26 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 16 27 100 100 CD work_gukk34cj2ba2hfeeqnbcodfs6m 16 28 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 16 29 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 16 30 expansion.15 expansion.15 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 16 31 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 16 32 17 17 CD work_gukk34cj2ba2hfeeqnbcodfs6m 16 33 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 34 early early JJ work_gukk34cj2ba2hfeeqnbcodfs6m 16 35 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 16 36 up up IN work_gukk34cj2ba2hfeeqnbcodfs6m 16 37 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 16 38 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 39 1500s 1500 NNS work_gukk34cj2ba2hfeeqnbcodfs6m 16 40 covered cover VBN work_gukk34cj2ba2hfeeqnbcodfs6m 16 41 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 16 42 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 43 southwest southwest NN work_gukk34cj2ba2hfeeqnbcodfs6m 16 44 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 16 45 southeast southeast JJ work_gukk34cj2ba2hfeeqnbcodfs6m 16 46 regions region NNS work_gukk34cj2ba2hfeeqnbcodfs6m 16 47 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 16 48 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 49 coastal coastal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 16 50 areas area NNS work_gukk34cj2ba2hfeeqnbcodfs6m 16 51 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 16 52 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 16 53 country country NN work_gukk34cj2ba2hfeeqnbcodfs6m 16 54 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 17 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 17 2 northern northern JJ work_gukk34cj2ba2hfeeqnbcodfs6m 17 3 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 17 4 eastern eastern JJ work_gukk34cj2ba2hfeeqnbcodfs6m 17 5 area area NN work_gukk34cj2ba2hfeeqnbcodfs6m 17 6 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 17 7 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 17 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 17 9 late late JJ work_gukk34cj2ba2hfeeqnbcodfs6m 17 10 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 17 11 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 17 12 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 17 13 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 17 14 inhabited inhabit VBN work_gukk34cj2ba2hfeeqnbcodfs6m 17 15 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 17 16 15 15 CD work_gukk34cj2ba2hfeeqnbcodfs6m 17 17 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 17 18 25 25 CD work_gukk34cj2ba2hfeeqnbcodfs6m 17 19 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 17 20 ago ago RB work_gukk34cj2ba2hfeeqnbcodfs6m 17 21 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 18 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 18 2 archaeological archaeological JJ work_gukk34cj2ba2hfeeqnbcodfs6m 18 3 findings finding NNS work_gukk34cj2ba2hfeeqnbcodfs6m 18 4 confirm confirm VBP work_gukk34cj2ba2hfeeqnbcodfs6m 18 5 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 18 6 there there EX work_gukk34cj2ba2hfeeqnbcodfs6m 18 7 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 18 8 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 18 9 sparse sparse JJ work_gukk34cj2ba2hfeeqnbcodfs6m 18 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 18 11 although although IN work_gukk34cj2ba2hfeeqnbcodfs6m 18 12 continuous continuous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 18 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 18 14 inhabitation inhabitation NN work_gukk34cj2ba2hfeeqnbcodfs6m 18 15 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 18 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 18 17 southern southern JJ work_gukk34cj2ba2hfeeqnbcodfs6m 18 18 coastal coastal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 18 19 areas area NNS work_gukk34cj2ba2hfeeqnbcodfs6m 18 20 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 18 21 about about RB work_gukk34cj2ba2hfeeqnbcodfs6m 18 22 10 10 CD work_gukk34cj2ba2hfeeqnbcodfs6m 18 23 000 000 CD work_gukk34cj2ba2hfeeqnbcodfs6m 18 24 years year NNS work_gukk34cj2ba2hfeeqnbcodfs6m 18 25 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 18 26 http://virtual.finland.fi/finfo/english/prehistory.html http://virtual.finland.fi/finfo/english/prehistory.html NNP work_gukk34cj2ba2hfeeqnbcodfs6m 18 27 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 18 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 19 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 19 2 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 19 3 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 19 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 19 5 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 19 6 describe describe VBP work_gukk34cj2ba2hfeeqnbcodfs6m 19 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 19 8 results result NNS work_gukk34cj2ba2hfeeqnbcodfs6m 19 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 19 10 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 19 11 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 19 12 muta- muta- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 19 13 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 19 14 analyses analysis NNS work_gukk34cj2ba2hfeeqnbcodfs6m 19 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 19 16 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 19 17 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 19 18 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 19 19 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 19 20 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 19 21 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 19 22 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 19 23 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 19 24 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 19 25 44 44 CD work_gukk34cj2ba2hfeeqnbcodfs6m 19 26 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 19 27 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 19 28 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 19 29 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 19 30 nationalities nationality NNS work_gukk34cj2ba2hfeeqnbcodfs6m 19 31 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 20 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 20 2 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 20 3 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 20 4 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 20 5 introduced introduce VBN work_gukk34cj2ba2hfeeqnbcodfs6m 20 6 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 20 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 20 8 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 20 9 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 20 10 3900 3900 CD work_gukk34cj2ba2hfeeqnbcodfs6m 20 11 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 20 12 4800 4800 CD work_gukk34cj2ba2hfeeqnbcodfs6m 20 13 years year NNS work_gukk34cj2ba2hfeeqnbcodfs6m 20 14 ago ago RB work_gukk34cj2ba2hfeeqnbcodfs6m 20 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 20 16 obviously obviously RB work_gukk34cj2ba2hfeeqnbcodfs6m 20 17 well well RB work_gukk34cj2ba2hfeeqnbcodfs6m 20 18 before before IN work_gukk34cj2ba2hfeeqnbcodfs6m 20 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 20 20 expan- expan- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 20 21 sion sion NN work_gukk34cj2ba2hfeeqnbcodfs6m 20 22 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 20 23 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 20 24 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 20 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 21 1 Currently currently RB work_gukk34cj2ba2hfeeqnbcodfs6m 21 2 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 21 3 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 21 4 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 21 5 contributes contribute VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 21 6 92 92 CD work_gukk34cj2ba2hfeeqnbcodfs6m 21 7 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 21 8 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 21 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 21 10 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 21 11 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 21 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 21 13 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 21 14 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 21 15 48 48 CD work_gukk34cj2ba2hfeeqnbcodfs6m 21 16 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 21 17 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 21 18 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 21 19 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 21 20 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 21 21 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 21 22 collection collection NN work_gukk34cj2ba2hfeeqnbcodfs6m 21 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 21 24 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 21 25 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 21 26 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 21 27 several several JJ work_gukk34cj2ba2hfeeqnbcodfs6m 21 28 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 21 29 populations population NNS work_gukk34cj2ba2hfeeqnbcodfs6m 21 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 22 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 22 2 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 22 3 demonstrated demonstrate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 22 4 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 22 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 22 6 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 22 7 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 22 8 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 22 9 segregating segregate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 22 10 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 22 11 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 22 12 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 22 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 22 14 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 22 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 22 16 abroad abroad RB work_gukk34cj2ba2hfeeqnbcodfs6m 22 17 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 22 18 thus thus RB work_gukk34cj2ba2hfeeqnbcodfs6m 22 19 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 22 20 suggesting suggest VBG work_gukk34cj2ba2hfeeqnbcodfs6m 22 21 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 22 22 single single JJ work_gukk34cj2ba2hfeeqnbcodfs6m 22 23 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 22 24 occurrence occurrence NN work_gukk34cj2ba2hfeeqnbcodfs6m 22 25 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 22 26 worldwide worldwide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 22 27 distribution distribution NN work_gukk34cj2ba2hfeeqnbcodfs6m 22 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 23 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 2 total total JJ work_gukk34cj2ba2hfeeqnbcodfs6m 23 3 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 23 4 eight eight CD work_gukk34cj2ba2hfeeqnbcodfs6m 23 5 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 23 6 muta- muta- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 23 7 tions tion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 23 8 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 23 10 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 23 11 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 23 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 23 13 28 28 CD work_gukk34cj2ba2hfeeqnbcodfs6m 23 14 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 23 15 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 23 17 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 18 coding code VBG work_gukk34cj2ba2hfeeqnbcodfs6m 23 19 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 23 20 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 21 267 267 CD work_gukk34cj2ba2hfeeqnbcodfs6m 23 22 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 23 23 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 23 24 now now RB work_gukk34cj2ba2hfeeqnbcodfs6m 23 25 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 23 26 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 23 27 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 23 28 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 23 29 study).12 study).12 CD work_gukk34cj2ba2hfeeqnbcodfs6m 23 30 Materials material NNS work_gukk34cj2ba2hfeeqnbcodfs6m 23 31 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 23 32 methods method NNS work_gukk34cj2ba2hfeeqnbcodfs6m 23 33 Subjects subject NNS work_gukk34cj2ba2hfeeqnbcodfs6m 23 34 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 23 35 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 23 36 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 23 37 molecular molecular JJ work_gukk34cj2ba2hfeeqnbcodfs6m 23 38 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 23 39 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 23 40 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 41 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 42 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 23 43 approved approve VBN work_gukk34cj2ba2hfeeqnbcodfs6m 23 44 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 45 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 23 46 ethical ethical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 23 47 committee committee NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 48 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 49 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 23 50 Department Department NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 51 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 52 Medical Medical NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 53 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 54 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 55 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 23 56 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 57 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 23 58 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 23 59 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 24 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 24 2 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 24 3 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 24 4 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 24 5 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 24 6 referred refer VBN work_gukk34cj2ba2hfeeqnbcodfs6m 24 7 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 8 diagnostic diagnostic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 24 9 workup workup NN work_gukk34cj2ba2hfeeqnbcodfs6m 24 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 24 11 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 24 12 counselling counselling NN work_gukk34cj2ba2hfeeqnbcodfs6m 24 13 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 14 all all RB work_gukk34cj2ba2hfeeqnbcodfs6m 24 15 over over IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 24 17 country country NN work_gukk34cj2ba2hfeeqnbcodfs6m 24 18 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 24 20 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 24 21 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 24 22 Central Central NNP work_gukk34cj2ba2hfeeqnbcodfs6m 24 23 Hospital Hospital NNP work_gukk34cj2ba2hfeeqnbcodfs6m 24 24 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 24 25 where where WRB work_gukk34cj2ba2hfeeqnbcodfs6m 24 26 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 24 27 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 24 28 registry registry NN work_gukk34cj2ba2hfeeqnbcodfs6m 24 29 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 24 30 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 24 31 maintained maintain VBN work_gukk34cj2ba2hfeeqnbcodfs6m 24 32 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 33 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 24 34 epidemiological epidemiological JJ work_gukk34cj2ba2hfeeqnbcodfs6m 24 35 surveys survey NNS work_gukk34cj2ba2hfeeqnbcodfs6m 24 36 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 37 1974 1974 CD work_gukk34cj2ba2hfeeqnbcodfs6m 24 38 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 24 39 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 40 1986.2 1986.2 CD work_gukk34cj2ba2hfeeqnbcodfs6m 24 41 Since since IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 42 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 24 43 surveys survey NNS work_gukk34cj2ba2hfeeqnbcodfs6m 24 44 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 24 45 additional additional JJ work_gukk34cj2ba2hfeeqnbcodfs6m 24 46 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 24 47 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 24 48 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 24 49 studied study VBN work_gukk34cj2ba2hfeeqnbcodfs6m 24 50 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 24 51 evaluated evaluate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 24 52 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 24 53 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 24 54 current current JJ work_gukk34cj2ba2hfeeqnbcodfs6m 24 55 number number NN work_gukk34cj2ba2hfeeqnbcodfs6m 24 56 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 57 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 24 58 being be VBG work_gukk34cj2ba2hfeeqnbcodfs6m 24 59 158 158 CD work_gukk34cj2ba2hfeeqnbcodfs6m 24 60 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 24 61 127 127 CD work_gukk34cj2ba2hfeeqnbcodfs6m 24 62 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 24 63 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 25 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 25 2 clinical clinical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 25 3 diagnostic diagnostic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 25 4 features feature NNS work_gukk34cj2ba2hfeeqnbcodfs6m 25 5 include include VBP work_gukk34cj2ba2hfeeqnbcodfs6m 25 6 disproportionate disproportionate JJ work_gukk34cj2ba2hfeeqnbcodfs6m 25 7 short short RB work_gukk34cj2ba2hfeeqnbcodfs6m 25 8 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 25 9 limbed limbed JJ work_gukk34cj2ba2hfeeqnbcodfs6m 25 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 25 11 short short JJ work_gukk34cj2ba2hfeeqnbcodfs6m 25 12 stature stature NN work_gukk34cj2ba2hfeeqnbcodfs6m 25 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 25 14 increased increase VBD work_gukk34cj2ba2hfeeqnbcodfs6m 25 15 lumbar lumbar NN work_gukk34cj2ba2hfeeqnbcodfs6m 25 16 lordosis lordosis NN work_gukk34cj2ba2hfeeqnbcodfs6m 25 17 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 25 18 joint joint JJ work_gukk34cj2ba2hfeeqnbcodfs6m 25 19 laxity laxity NN work_gukk34cj2ba2hfeeqnbcodfs6m 25 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 25 21 extension extension NN work_gukk34cj2ba2hfeeqnbcodfs6m 25 22 limitation limitation NN work_gukk34cj2ba2hfeeqnbcodfs6m 25 23 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 25 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 25 25 elbows elbow NNS work_gukk34cj2ba2hfeeqnbcodfs6m 25 26 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 25 27 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 25 28 bowed bow VBD work_gukk34cj2ba2hfeeqnbcodfs6m 25 29 legs leg NNS work_gukk34cj2ba2hfeeqnbcodfs6m 25 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 26 1 Usually usually RB work_gukk34cj2ba2hfeeqnbcodfs6m 26 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 26 3 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 26 4 presented present VBD work_gukk34cj2ba2hfeeqnbcodfs6m 26 5 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 26 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 26 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 26 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 26 9 but but CC work_gukk34cj2ba2hfeeqnbcodfs6m 26 10 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 26 11 inclusion inclusion NN work_gukk34cj2ba2hfeeqnbcodfs6m 26 12 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 26 13 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 26 14 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 26 15 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 26 16 accepted accept VBN work_gukk34cj2ba2hfeeqnbcodfs6m 26 17 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 26 18 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 26 19 confirmatory confirmatory JJ work_gukk34cj2ba2hfeeqnbcodfs6m 26 20 feature feature NN work_gukk34cj2ba2hfeeqnbcodfs6m 26 21 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 26 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 27 1 Radiological radiological JJ work_gukk34cj2ba2hfeeqnbcodfs6m 27 2 find- find- NN work_gukk34cj2ba2hfeeqnbcodfs6m 27 3 ings ing NNS work_gukk34cj2ba2hfeeqnbcodfs6m 27 4 included include VBD work_gukk34cj2ba2hfeeqnbcodfs6m 27 5 generalised generalise VBN work_gukk34cj2ba2hfeeqnbcodfs6m 27 6 metaphyseal metaphyseal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 27 7 dysplasia dysplasia NNS work_gukk34cj2ba2hfeeqnbcodfs6m 27 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 27 9 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 27 10 normal normal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 27 11 skull skull NN work_gukk34cj2ba2hfeeqnbcodfs6m 27 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 27 13 spine spine NN work_gukk34cj2ba2hfeeqnbcodfs6m 27 14 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 27 15 childhood childhood NN work_gukk34cj2ba2hfeeqnbcodfs6m 27 16 films film NNS work_gukk34cj2ba2hfeeqnbcodfs6m 27 17 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 28 1 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 28 2 total total NN work_gukk34cj2ba2hfeeqnbcodfs6m 28 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 28 4 115 115 CD work_gukk34cj2ba2hfeeqnbcodfs6m 28 5 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 28 6 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 28 7 91 91 CD work_gukk34cj2ba2hfeeqnbcodfs6m 28 8 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 28 9 agreed agree VBD work_gukk34cj2ba2hfeeqnbcodfs6m 28 10 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 28 11 participate participate VB work_gukk34cj2ba2hfeeqnbcodfs6m 28 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 28 13 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 28 14 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 28 15 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 28 16 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 28 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 28 18 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 28 19 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 28 20 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 28 21 custodians custodian NNS work_gukk34cj2ba2hfeeqnbcodfs6m 28 22 signed sign VBD work_gukk34cj2ba2hfeeqnbcodfs6m 28 23 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 28 24 informed informed JJ work_gukk34cj2ba2hfeeqnbcodfs6m 28 25 consent consent NN work_gukk34cj2ba2hfeeqnbcodfs6m 28 26 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 29 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 29 2 birthplaces birthplace NNS work_gukk34cj2ba2hfeeqnbcodfs6m 29 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 29 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 29 5 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 29 6 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 29 7 ’ ’ POS work_gukk34cj2ba2hfeeqnbcodfs6m 29 8 great- great- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 29 9 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 29 10 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 29 11 inspected inspect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 29 12 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 29 13 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 29 14 church church NN work_gukk34cj2ba2hfeeqnbcodfs6m 29 15 parish parish NN work_gukk34cj2ba2hfeeqnbcodfs6m 29 16 regis- regis- NN work_gukk34cj2ba2hfeeqnbcodfs6m 29 17 ters ter NNS work_gukk34cj2ba2hfeeqnbcodfs6m 29 18 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 30 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 30 2 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 30 3 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 30 4 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 30 5 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 30 6 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 30 7 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 30 8 number number NN work_gukk34cj2ba2hfeeqnbcodfs6m 30 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 30 10 countries country NNS work_gukk34cj2ba2hfeeqnbcodfs6m 30 11 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 30 12 collected collect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 30 13 through through IN work_gukk34cj2ba2hfeeqnbcodfs6m 30 14 diagnostic diagnostic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 30 15 consultations consultation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 30 16 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 30 17 clini- clini- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 30 18 cians cian NNS work_gukk34cj2ba2hfeeqnbcodfs6m 30 19 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 30 20 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 30 21 counsellors counsellor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 30 22 named name VBN work_gukk34cj2ba2hfeeqnbcodfs6m 30 23 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 30 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 30 25 acknowledgments acknowledgment NNS work_gukk34cj2ba2hfeeqnbcodfs6m 30 26 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 31 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 31 2 essential essential JJ work_gukk34cj2ba2hfeeqnbcodfs6m 31 3 diagnostic diagnostic NN work_gukk34cj2ba2hfeeqnbcodfs6m 31 4 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 31 5 demo- demo- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 31 6 graphic graphic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 31 7 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 8 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 31 9 obtained obtain VBN work_gukk34cj2ba2hfeeqnbcodfs6m 31 10 through through IN work_gukk34cj2ba2hfeeqnbcodfs6m 31 11 clinical clinical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 31 12 descriptions description NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 31 14 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 15 ’ ’ POS work_gukk34cj2ba2hfeeqnbcodfs6m 31 16 photographs photograph NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 17 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 31 18 laboratory laboratory NN work_gukk34cj2ba2hfeeqnbcodfs6m 31 19 results result NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 31 21 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 31 22 copies copy NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 31 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 31 25 skeletal skeletal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 31 26 radiographs radiograph NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 27 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 31 28 most most JJS work_gukk34cj2ba2hfeeqnbcodfs6m 31 29 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 31 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 32 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 32 2 addition addition NN work_gukk34cj2ba2hfeeqnbcodfs6m 32 3 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 32 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 32 5 consultants consultant NNS work_gukk34cj2ba2hfeeqnbcodfs6m 32 6 filled fill VBN work_gukk34cj2ba2hfeeqnbcodfs6m 32 7 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 32 8 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 32 9 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 32 10 data data NN work_gukk34cj2ba2hfeeqnbcodfs6m 32 11 form form NN work_gukk34cj2ba2hfeeqnbcodfs6m 32 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 33 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 33 2 ethnic ethnic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 33 3 back- back- NN work_gukk34cj2ba2hfeeqnbcodfs6m 33 4 ground ground NN work_gukk34cj2ba2hfeeqnbcodfs6m 33 5 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 33 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 33 7 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 33 8 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 33 9 America America NNP work_gukk34cj2ba2hfeeqnbcodfs6m 33 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 33 11 Australia Australia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 33 12 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 33 13 often often RB work_gukk34cj2ba2hfeeqnbcodfs6m 33 14 European european JJ work_gukk34cj2ba2hfeeqnbcodfs6m 33 15 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 34 1 Data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 34 2 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 34 3 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 34 4 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 34 5 obtained obtain VBN work_gukk34cj2ba2hfeeqnbcodfs6m 34 6 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 34 7 63 63 CD work_gukk34cj2ba2hfeeqnbcodfs6m 34 8 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 34 9 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 34 10 53 53 CD work_gukk34cj2ba2hfeeqnbcodfs6m 34 11 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 34 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 35 1 Seven seven CD work_gukk34cj2ba2hfeeqnbcodfs6m 35 2 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 35 3 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 35 4 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 35 5 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 35 6 obtained obtain VBN work_gukk34cj2ba2hfeeqnbcodfs6m 35 7 through through IN work_gukk34cj2ba2hfeeqnbcodfs6m 35 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 35 9 International International NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 10 Skeletal Skeletal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 11 Dysplasia Dysplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 12 Regis- Regis- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 13 try try NN work_gukk34cj2ba2hfeeqnbcodfs6m 35 14 maintained maintain VBD work_gukk34cj2ba2hfeeqnbcodfs6m 35 15 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 35 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 35 17 Cedars Cedars NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 18 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 35 19 Sinai Sinai NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 20 Medical Medical NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 21 Center Center NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 22 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 35 23 Los Los NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 24 Angeles Angeles NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 25 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 35 26 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 35 27 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 36 1 DNA dna NN work_gukk34cj2ba2hfeeqnbcodfs6m 36 2 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 36 3 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 36 4 845 845 CD work_gukk34cj2ba2hfeeqnbcodfs6m 36 5 regular regular JJ work_gukk34cj2ba2hfeeqnbcodfs6m 36 6 blood blood NN work_gukk34cj2ba2hfeeqnbcodfs6m 36 7 donors donor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 36 8 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 36 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 36 10 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 36 11 Red Red NNP work_gukk34cj2ba2hfeeqnbcodfs6m 36 12 Cross Cross NNP work_gukk34cj2ba2hfeeqnbcodfs6m 36 13 Blood Blood NNP work_gukk34cj2ba2hfeeqnbcodfs6m 36 14 Transfusion Transfusion NNP work_gukk34cj2ba2hfeeqnbcodfs6m 36 15 Service Service NNP work_gukk34cj2ba2hfeeqnbcodfs6m 36 16 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 36 17 studied study VBN work_gukk34cj2ba2hfeeqnbcodfs6m 36 18 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 36 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 36 20 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 36 21 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 36 22 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 36 23 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 36 24 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 36 25 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 36 26 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 36 27 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 37 1 Smaller small JJR work_gukk34cj2ba2hfeeqnbcodfs6m 37 2 sets set NNS work_gukk34cj2ba2hfeeqnbcodfs6m 37 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 37 4 control control NN work_gukk34cj2ba2hfeeqnbcodfs6m 37 5 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 37 6 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 37 7 studied study VBN work_gukk34cj2ba2hfeeqnbcodfs6m 37 8 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 37 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 37 10 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 37 11 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 37 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 38 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 2 control control NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 3 sample sample NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 4 registry registry NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 5 consists consist VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 38 6 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 7 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 8 total total NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 10 971 971 CD work_gukk34cj2ba2hfeeqnbcodfs6m 38 11 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 38 12 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 13 35 35 CD work_gukk34cj2ba2hfeeqnbcodfs6m 38 14 – – SYM work_gukk34cj2ba2hfeeqnbcodfs6m 38 15 55 55 CD work_gukk34cj2ba2hfeeqnbcodfs6m 38 16 year year NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 17 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 38 18 old old JJ work_gukk34cj2ba2hfeeqnbcodfs6m 38 19 male male JJ work_gukk34cj2ba2hfeeqnbcodfs6m 38 20 donors donor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 38 21 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 38 22 all all DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 24 whose whose WP$ work_gukk34cj2ba2hfeeqnbcodfs6m 38 25 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 38 26 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 38 27 born bear VBN work_gukk34cj2ba2hfeeqnbcodfs6m 38 28 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 29 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 30 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 38 31 geographic geographic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 38 32 area area NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 33 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 34 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 38 35 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 38 36 who who WP work_gukk34cj2ba2hfeeqnbcodfs6m 38 37 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 38 38 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 38 39 aware aware JJ work_gukk34cj2ba2hfeeqnbcodfs6m 38 40 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 41 any any DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 42 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 43 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 38 44 relatives relative NNS work_gukk34cj2ba2hfeeqnbcodfs6m 38 45 participating participate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 38 46 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 47 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 48 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 49 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 38 50 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 38 51 had have VBD work_gukk34cj2ba2hfeeqnbcodfs6m 38 52 no no DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 53 knowledge knowledge NN work_gukk34cj2ba2hfeeqnbcodfs6m 38 54 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 55 any any DT work_gukk34cj2ba2hfeeqnbcodfs6m 38 56 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 57 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 38 58 more more RBR work_gukk34cj2ba2hfeeqnbcodfs6m 38 59 distant distant JJ work_gukk34cj2ba2hfeeqnbcodfs6m 38 60 ancestors ancestor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 38 61 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 38 62 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 38 63 abroad abroad RB work_gukk34cj2ba2hfeeqnbcodfs6m 38 64 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 39 1 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 39 2 sample sample NN work_gukk34cj2ba2hfeeqnbcodfs6m 39 3 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 39 4 accepted accept VBN work_gukk34cj2ba2hfeeqnbcodfs6m 39 5 after after IN work_gukk34cj2ba2hfeeqnbcodfs6m 39 6 obtaining obtain VBG work_gukk34cj2ba2hfeeqnbcodfs6m 39 7 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 39 8 written write VBN work_gukk34cj2ba2hfeeqnbcodfs6m 39 9 informed informed JJ work_gukk34cj2ba2hfeeqnbcodfs6m 39 10 consent consent NN work_gukk34cj2ba2hfeeqnbcodfs6m 39 11 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 39 12 fulfilling fulfil VBG work_gukk34cj2ba2hfeeqnbcodfs6m 39 13 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 39 14 criteria criterion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 39 15 above above RB work_gukk34cj2ba2hfeeqnbcodfs6m 39 16 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 40 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 40 2 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 40 3 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 40 4 collected collect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 40 5 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 40 6 eight eight CD work_gukk34cj2ba2hfeeqnbcodfs6m 40 7 regional regional JJ work_gukk34cj2ba2hfeeqnbcodfs6m 40 8 centres centre NNS work_gukk34cj2ba2hfeeqnbcodfs6m 40 9 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 40 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 40 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 40 12 sampling sampling NN work_gukk34cj2ba2hfeeqnbcodfs6m 40 13 density density NN work_gukk34cj2ba2hfeeqnbcodfs6m 40 14 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 40 15 representative representative JJ work_gukk34cj2ba2hfeeqnbcodfs6m 40 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 40 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 40 18 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 40 19 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 40 20 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 40 21 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 40 22 start start NN work_gukk34cj2ba2hfeeqnbcodfs6m 40 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 40 24 1900 1900 CD work_gukk34cj2ba2hfeeqnbcodfs6m 40 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 41 1 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 41 2 sample sample NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 3 consisted consist VBD work_gukk34cj2ba2hfeeqnbcodfs6m 41 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 41 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 41 6 buffy buffy NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 7 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 41 8 coat coat NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 41 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 41 11 whole whole JJ work_gukk34cj2ba2hfeeqnbcodfs6m 41 12 donation donation NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 13 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 41 14 about about RB work_gukk34cj2ba2hfeeqnbcodfs6m 41 15 450 450 CD work_gukk34cj2ba2hfeeqnbcodfs6m 41 16 ml ml NNS work_gukk34cj2ba2hfeeqnbcodfs6m 41 17 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 41 18 generated generate VBD work_gukk34cj2ba2hfeeqnbcodfs6m 41 19 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 41 20 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 41 21 side side JJ work_gukk34cj2ba2hfeeqnbcodfs6m 41 22 product product NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 23 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 41 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 41 25 routine routine JJ work_gukk34cj2ba2hfeeqnbcodfs6m 41 26 preparation preparation NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 27 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 41 28 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 41 29 leukocyte leukocyte NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 30 depleted deplete VBN work_gukk34cj2ba2hfeeqnbcodfs6m 41 31 red red JJ work_gukk34cj2ba2hfeeqnbcodfs6m 41 32 cell cell NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 33 unit unit NN work_gukk34cj2ba2hfeeqnbcodfs6m 41 34 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 42 1 DNA DNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 42 2 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 42 3 extracted extract VBN work_gukk34cj2ba2hfeeqnbcodfs6m 42 4 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 42 5 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 42 6 modified modify VBN work_gukk34cj2ba2hfeeqnbcodfs6m 42 7 salting salt VBG work_gukk34cj2ba2hfeeqnbcodfs6m 42 8 out out RP work_gukk34cj2ba2hfeeqnbcodfs6m 42 9 protocol.18 protocol.18 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 42 10 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 42 11 ethical ethical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 42 12 committee committee NN work_gukk34cj2ba2hfeeqnbcodfs6m 42 13 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 42 14 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 42 15 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 42 16 Red Red NNP work_gukk34cj2ba2hfeeqnbcodfs6m 42 17 Cross Cross NNP work_gukk34cj2ba2hfeeqnbcodfs6m 42 18 Blood Blood NNP work_gukk34cj2ba2hfeeqnbcodfs6m 42 19 Transfusion Transfusion NNP work_gukk34cj2ba2hfeeqnbcodfs6m 42 20 Service Service NNP work_gukk34cj2ba2hfeeqnbcodfs6m 42 21 approved approve VBD work_gukk34cj2ba2hfeeqnbcodfs6m 42 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 42 23 sample sample NN work_gukk34cj2ba2hfeeqnbcodfs6m 42 24 registry registry NN work_gukk34cj2ba2hfeeqnbcodfs6m 42 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 43 1 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 43 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 43 4 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 43 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 8 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 9 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 12 440 440 CD work_gukk34cj2ba2hfeeqnbcodfs6m 43 13 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 14 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 43 16 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 17 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 18 Mutation Mutation NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 19 detection detection NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 20 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 43 21 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 22 DNA DNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 23 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 43 24 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 43 25 screened screen VBN work_gukk34cj2ba2hfeeqnbcodfs6m 43 26 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 43 27 insertions insertion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 43 28 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 43 29 deletions deletion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 43 30 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 43 31 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 43 32 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 33 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 34 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 43 35 PCR PCR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 36 primers primer VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 43 37 RM3IF RM3IF NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 38 5’-CTTA- 5’-ctta- CD work_gukk34cj2ba2hfeeqnbcodfs6m 43 39 GAAAGTTATGCCCGAAAAC-3 GAAAGTTATGCCCGAAAAC-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 40 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 43 41 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 43 42 RM3IR RM3IR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 43 5’-GAAAGG- 5’-gaaagg- CD work_gukk34cj2ba2hfeeqnbcodfs6m 43 44 GGAGGAACAGAGTC-3 ggaggaacagagtc-3 NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 45 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 43 46 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 43 47 amplification amplification NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 48 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 43 49 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 43 50 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 51 Sequagel Sequagel NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 52 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 43 53 National National NNP work_gukk34cj2ba2hfeeqnbcodfs6m 43 54 Diagnostics Diagnostics NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 43 55 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 43 56 gels gel VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 43 57 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 43 58 separation separation NN work_gukk34cj2ba2hfeeqnbcodfs6m 43 59 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 44 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 44 2 case case NN work_gukk34cj2ba2hfeeqnbcodfs6m 44 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 44 4 changes change NNS work_gukk34cj2ba2hfeeqnbcodfs6m 44 5 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 44 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 44 7 length length NN work_gukk34cj2ba2hfeeqnbcodfs6m 44 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 44 9 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 44 10 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 44 11 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 44 12 amplified amplify VBN work_gukk34cj2ba2hfeeqnbcodfs6m 44 13 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 44 14 RM3F RM3F NNP work_gukk34cj2ba2hfeeqnbcodfs6m 44 15 5’-GGCCAGACCATATTTGCATAAG-3 5’-GGCCAGACCATATTTGCATAAG-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 44 16 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 44 17 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 44 18 RM3R rm3r UH work_gukk34cj2ba2hfeeqnbcodfs6m 44 19 5’- 5’- CD work_gukk34cj2ba2hfeeqnbcodfs6m 44 20 CGGACTTTGGAGTGGGAAG-3 CGGACTTTGGAGTGGGAAG-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 44 21 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 44 22 primers primer NNS work_gukk34cj2ba2hfeeqnbcodfs6m 44 23 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 44 24 sequenced sequence VBN work_gukk34cj2ba2hfeeqnbcodfs6m 44 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 45 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 45 2 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 45 3 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 45 4 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 45 5 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 45 6 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 45 7 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 45 8 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 45 9 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 45 10 amplified amplify VBN work_gukk34cj2ba2hfeeqnbcodfs6m 45 11 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 45 12 PCR PCR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 45 13 primers primer NNS work_gukk34cj2ba2hfeeqnbcodfs6m 45 14 RM70F RM70F . work_gukk34cj2ba2hfeeqnbcodfs6m 45 15 5’-GTGCTGAAGGCCTGTATCCT-3 5’-gtgctgaaggcctgtatcct-3 CD work_gukk34cj2ba2hfeeqnbcodfs6m 45 16 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 45 17 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 45 18 RM70R rm70r VBP work_gukk34cj2ba2hfeeqnbcodfs6m 45 19 5’-CTAGGGGAGCTGACGGATG-3 5’-CTAGGGGAGCTGACGGATG-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 45 20 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 45 21 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 46 1 SSCP SSCP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 46 2 analyses analysis NNS work_gukk34cj2ba2hfeeqnbcodfs6m 46 3 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 46 4 performed perform VBN work_gukk34cj2ba2hfeeqnbcodfs6m 46 5 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 46 6 0.7xMDE 0.7xmde CD work_gukk34cj2ba2hfeeqnbcodfs6m 46 7 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 46 8 FMC FMC NNP work_gukk34cj2ba2hfeeqnbcodfs6m 46 9 BioProducts BioProducts NNP work_gukk34cj2ba2hfeeqnbcodfs6m 46 10 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 46 11 gels gel VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 46 12 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 46 13 room room NN work_gukk34cj2ba2hfeeqnbcodfs6m 46 14 temperature temperature NN work_gukk34cj2ba2hfeeqnbcodfs6m 46 15 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 46 16 5W 5W NNP work_gukk34cj2ba2hfeeqnbcodfs6m 46 17 overnight overnight RB work_gukk34cj2ba2hfeeqnbcodfs6m 46 18 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 47 1 For for IN work_gukk34cj2ba2hfeeqnbcodfs6m 47 2 sequen- sequen- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 47 3 cing cing NN work_gukk34cj2ba2hfeeqnbcodfs6m 47 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 47 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 47 6 whole whole JJ work_gukk34cj2ba2hfeeqnbcodfs6m 47 7 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 47 8 coding code VBG work_gukk34cj2ba2hfeeqnbcodfs6m 47 9 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 47 10 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 47 11 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 47 12 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 47 13 PCR PCR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 47 14 primers primer NNS work_gukk34cj2ba2hfeeqnbcodfs6m 47 15 RMF RMF NNP work_gukk34cj2ba2hfeeqnbcodfs6m 47 16 5’-CCAACTTTCTCACCCTAACCA-3 5’-CCAACTTTCTCACCCTAACCA-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 47 17 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 47 18 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 47 19 RMR RMR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 47 20 5’-AAGGCCAAGAACAGCGTAAA-3 5’-AAGGCCAAGAACAGCGTAAA-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 47 21 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 47 22 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 47 23 used use VBN work_gukk34cj2ba2hfeeqnbcodfs6m 47 24 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 48 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 48 2 some some DT work_gukk34cj2ba2hfeeqnbcodfs6m 48 3 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 48 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 48 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 48 6 3 3 CD work_gukk34cj2ba2hfeeqnbcodfs6m 48 7 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 48 8 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 48 9 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 48 10 separately separately RB work_gukk34cj2ba2hfeeqnbcodfs6m 48 11 amplified amplify VBN work_gukk34cj2ba2hfeeqnbcodfs6m 48 12 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 48 13 sequen- sequen- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 48 14 cing ce VBG work_gukk34cj2ba2hfeeqnbcodfs6m 48 15 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 48 16 RM4F RM4F NNP work_gukk34cj2ba2hfeeqnbcodfs6m 48 17 5’-AGAGAGTGCCACGTGCATAC-3 5’-AGAGAGTGCCACGTGCATAC-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 48 18 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 48 19 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 48 20 RM4R RM4R NNP work_gukk34cj2ba2hfeeqnbcodfs6m 48 21 5’-CTTCATAGCAAGGCCAAGAAC-3 5’-CTTCATAGCAAGGCCAAGAAC-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 48 22 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 48 23 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 49 1 All all DT work_gukk34cj2ba2hfeeqnbcodfs6m 49 2 PAGE PAGE NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 3 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 49 4 SSCP SSCP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 5 gels gel NNS work_gukk34cj2ba2hfeeqnbcodfs6m 49 6 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 49 7 detected detect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 49 8 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 49 9 silver silver NN work_gukk34cj2ba2hfeeqnbcodfs6m 49 10 staining.19 staining.19 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 11 Analysis Analysis NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 12 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 49 13 polymorphic polymorphic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 49 14 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 49 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 49 16 reconstruction reconstruction NN work_gukk34cj2ba2hfeeqnbcodfs6m 49 17 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 49 18 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 49 19 Primers Primers NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 49 20 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 49 21 separation separation NN work_gukk34cj2ba2hfeeqnbcodfs6m 49 22 conditions condition NNS work_gukk34cj2ba2hfeeqnbcodfs6m 49 23 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 49 24 D9S163 d9s163 NN work_gukk34cj2ba2hfeeqnbcodfs6m 49 25 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 26 99AC 99ac CD work_gukk34cj2ba2hfeeqnbcodfs6m 49 27 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 28 TESK1 tesk1 ADD work_gukk34cj2ba2hfeeqnbcodfs6m 49 29 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 49 30 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 49 31 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 49 32 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 33 MN MN NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 34 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 49 35 CA9 CA9 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 36 C C NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 37 / / , work_gukk34cj2ba2hfeeqnbcodfs6m 49 38 A A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 39 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 40 D9S1804 D9S1804 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 41 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 42 89AC 89ac CD work_gukk34cj2ba2hfeeqnbcodfs6m 49 43 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 44 47K16T7 47k16t7 CD work_gukk34cj2ba2hfeeqnbcodfs6m 49 45 SSCP,11 SSCP,11 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 46 16P1 16p1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 49 47 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 48 AB12GS ab12gs NN work_gukk34cj2ba2hfeeqnbcodfs6m 49 49 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 50 Del13 Del13 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 51 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 52 SIT45S sit45s CD work_gukk34cj2ba2hfeeqnbcodfs6m 49 53 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 54 TP2A TP2A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 55 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 56 TA13S TA13S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 57 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 58 D4S D4S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 59 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 60 D6S D6S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 61 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 62 AC1 AC1 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 63 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 64 XL1S XL1S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 65 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 66 CCS CCS NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 67 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 49 68 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 49 69 TG2S12 TG2S12 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 49 70 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 49 71 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 49 72 described describe VBN work_gukk34cj2ba2hfeeqnbcodfs6m 49 73 previously previously RB work_gukk34cj2ba2hfeeqnbcodfs6m 49 74 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 50 1 Marker marker NN work_gukk34cj2ba2hfeeqnbcodfs6m 50 2 delG delG , work_gukk34cj2ba2hfeeqnbcodfs6m 50 3 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 50 4 amplified amplify VBN work_gukk34cj2ba2hfeeqnbcodfs6m 50 5 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 50 6 primers primer NNS work_gukk34cj2ba2hfeeqnbcodfs6m 50 7 5’-TGCATGCTG- 5’-tgcatgctg- CD work_gukk34cj2ba2hfeeqnbcodfs6m 50 8 CTTACTGGTTC-3 cttactggttc-3 NN work_gukk34cj2ba2hfeeqnbcodfs6m 50 9 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 50 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 50 11 5’-CCAATATCATGGGGGATGAC-3 5’-CCAATATCATGGGGGATGAC-3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 50 12 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 50 13 followed follow VBN work_gukk34cj2ba2hfeeqnbcodfs6m 50 14 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 50 15 separation separation NN work_gukk34cj2ba2hfeeqnbcodfs6m 50 16 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 50 17 0.7xMDE 0.7xmde CD work_gukk34cj2ba2hfeeqnbcodfs6m 50 18 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 50 19 FMC FMC NNP work_gukk34cj2ba2hfeeqnbcodfs6m 50 20 BioProducts BioProducts NNP work_gukk34cj2ba2hfeeqnbcodfs6m 50 21 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 50 22 SSCP SSCP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 50 23 gels gel VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 50 24 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 50 25 5W 5W NNP work_gukk34cj2ba2hfeeqnbcodfs6m 50 26 overnight overnight RB work_gukk34cj2ba2hfeeqnbcodfs6m 50 27 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 51 1 Primers primer NNS work_gukk34cj2ba2hfeeqnbcodfs6m 51 2 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 51 3 D9S165 d9s165 NN work_gukk34cj2ba2hfeeqnbcodfs6m 51 4 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 51 5 D9S1878 D9S1878 NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 51 6 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 51 7 as as RB work_gukk34cj2ba2hfeeqnbcodfs6m 51 8 described describe VBN work_gukk34cj2ba2hfeeqnbcodfs6m 51 9 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 51 10 http://www.cephb.fr http://www.cephb.fr NNP work_gukk34cj2ba2hfeeqnbcodfs6m 51 11 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 51 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 51 13 frag- frag- NN work_gukk34cj2ba2hfeeqnbcodfs6m 51 14 ments ment NNS work_gukk34cj2ba2hfeeqnbcodfs6m 51 15 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 51 16 separated separate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 51 17 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 51 18 6 6 CD work_gukk34cj2ba2hfeeqnbcodfs6m 51 19 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 51 20 Sequagel Sequagel NNP work_gukk34cj2ba2hfeeqnbcodfs6m 51 21 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 51 22 National National NNP work_gukk34cj2ba2hfeeqnbcodfs6m 51 23 Diagnostics Diagnostics NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 51 24 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 51 25 gels gel VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 51 26 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 51 27 508C. 508c. CD work_gukk34cj2ba2hfeeqnbcodfs6m 52 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 52 2 four four CD work_gukk34cj2ba2hfeeqnbcodfs6m 52 3 frequently frequently RB work_gukk34cj2ba2hfeeqnbcodfs6m 52 4 polymorphic polymorphic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 52 5 SNPs snp NNS work_gukk34cj2ba2hfeeqnbcodfs6m 52 6 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 52 7 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 52 8 7149T 7149T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 9 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 52 10 A A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 11 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 52 12 758T 758T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 13 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 52 14 C C NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 15 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 52 16 748C 748C NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 17 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 52 18 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 52 19 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 52 20 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 52 21 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 52 22 274T 274t CD work_gukk34cj2ba2hfeeqnbcodfs6m 52 23 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 52 24 C C NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 25 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 52 26 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 52 27 during during IN work_gukk34cj2ba2hfeeqnbcodfs6m 52 28 sequencing sequencing NN work_gukk34cj2ba2hfeeqnbcodfs6m 52 29 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 52 30 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 52 31 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 52 32 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 52 33 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 52 34 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 35 coding code VBG work_gukk34cj2ba2hfeeqnbcodfs6m 52 36 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 52 37 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 52 38 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 52 39 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 40 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 52 41 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 52 42 fragments fragment VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 52 43 RM3 RM3 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 44 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 52 45 RM4 RM4 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 46 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 52 47 RM RM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 52 48 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 52 49 described describe VBN work_gukk34cj2ba2hfeeqnbcodfs6m 52 50 above above RB work_gukk34cj2ba2hfeeqnbcodfs6m 52 51 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 52 52 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 53 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 53 2 distance distance NN work_gukk34cj2ba2hfeeqnbcodfs6m 53 3 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 53 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 53 5 transcription transcription NN work_gukk34cj2ba2hfeeqnbcodfs6m 53 6 initiation initiation NN work_gukk34cj2ba2hfeeqnbcodfs6m 53 7 site site NN work_gukk34cj2ba2hfeeqnbcodfs6m 53 8 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 53 9 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 53 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 53 11 each each DT work_gukk34cj2ba2hfeeqnbcodfs6m 53 12 marker marker NN work_gukk34cj2ba2hfeeqnbcodfs6m 53 13 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 53 14 determined determine VBN work_gukk34cj2ba2hfeeqnbcodfs6m 53 15 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 53 16 our -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 53 17 genomic genomic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 53 18 contigs12 contigs12 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 53 19 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 53 20 sequences sequence NNS work_gukk34cj2ba2hfeeqnbcodfs6m 53 21 AL133410 AL133410 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 53 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 53 23 AL135841 al135841 NN work_gukk34cj2ba2hfeeqnbcodfs6m 53 24 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 53 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 53 26 NCBI NCBI NNP work_gukk34cj2ba2hfeeqnbcodfs6m 53 27 data- data- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 53 28 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 53 29 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 53 30 http://www.ncbi.nlm.nih.gov/entrez http://www.ncbi.nlm.nih.gov/entrez NNP work_gukk34cj2ba2hfeeqnbcodfs6m 53 31 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 54 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 54 3 case case NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 5 AB12GS AB12GS NNP work_gukk34cj2ba2hfeeqnbcodfs6m 54 6 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 54 7 16P1 16p1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 54 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 54 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 54 10 length length NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 11 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 12 BAC BAC NNP work_gukk34cj2ba2hfeeqnbcodfs6m 54 13 clone clone NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 14 341J2 341J2 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 54 15 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 54 16 160 160 CD work_gukk34cj2ba2hfeeqnbcodfs6m 54 17 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 18 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 54 19 determined determine VBN work_gukk34cj2ba2hfeeqnbcodfs6m 54 20 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 21 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 54 22 pulsed pulse VBN work_gukk34cj2ba2hfeeqnbcodfs6m 54 23 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 54 24 field field NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 25 gel gel NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 26 electrophoresis electrophoresis NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 27 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 54 28 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 54 29 needed.11 needed.11 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 54 30 Haplotypes Haplotypes NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 54 31 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 32 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 54 33 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 54 34 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 54 35 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 54 36 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 54 37 recon- recon- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 54 38 structed structe VBD work_gukk34cj2ba2hfeeqnbcodfs6m 54 39 assuming assume VBG work_gukk34cj2ba2hfeeqnbcodfs6m 54 40 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 54 41 minimum minimum JJ work_gukk34cj2ba2hfeeqnbcodfs6m 54 42 number number NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 43 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 44 recombinations recombination NNS work_gukk34cj2ba2hfeeqnbcodfs6m 54 45 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 46 each each DT work_gukk34cj2ba2hfeeqnbcodfs6m 54 47 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 48 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 54 49 grouped group VBD work_gukk34cj2ba2hfeeqnbcodfs6m 54 50 according accord VBG work_gukk34cj2ba2hfeeqnbcodfs6m 54 51 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 52 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 54 53 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 54 54 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 54 55 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 54 56 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 55 1 Haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 55 2 segregating segregate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 55 3 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 55 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 55 5 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 55 6 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 55 7 muta- muta- NN work_gukk34cj2ba2hfeeqnbcodfs6m 55 8 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 55 9 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 55 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 55 11 healthy healthy JJ work_gukk34cj2ba2hfeeqnbcodfs6m 55 12 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 55 13 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 55 14 used use VBN work_gukk34cj2ba2hfeeqnbcodfs6m 55 15 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 55 16 calculate calculate VB work_gukk34cj2ba2hfeeqnbcodfs6m 55 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 55 18 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 55 19 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 55 20 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 55 21 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 55 22 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 55 23 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 55 24 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 55 25 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 55 26 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 56 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 56 2 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 56 3 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 56 4 showing show VBG work_gukk34cj2ba2hfeeqnbcodfs6m 56 5 UPD20 upd20 WRB work_gukk34cj2ba2hfeeqnbcodfs6m 56 6 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 56 7 excluded exclude VBN work_gukk34cj2ba2hfeeqnbcodfs6m 56 8 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 56 9 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 56 10 analysis analysis NN work_gukk34cj2ba2hfeeqnbcodfs6m 56 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 57 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 57 2 order order NN work_gukk34cj2ba2hfeeqnbcodfs6m 57 3 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 57 4 find find VB work_gukk34cj2ba2hfeeqnbcodfs6m 57 5 out out RP work_gukk34cj2ba2hfeeqnbcodfs6m 57 6 if if IN work_gukk34cj2ba2hfeeqnbcodfs6m 57 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 57 8 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 9 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 57 10 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 57 11 had have VBD work_gukk34cj2ba2hfeeqnbcodfs6m 57 12 arisen arise VBN work_gukk34cj2ba2hfeeqnbcodfs6m 57 13 once once RB work_gukk34cj2ba2hfeeqnbcodfs6m 57 14 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 57 15 several several JJ work_gukk34cj2ba2hfeeqnbcodfs6m 57 16 times time NNS work_gukk34cj2ba2hfeeqnbcodfs6m 57 17 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 57 18 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 57 19 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 57 20 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 57 21 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 57 22 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 23 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 57 24 homozygous homozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 57 25 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 57 26 heterozygous heterozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 57 27 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 57 28 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 57 29 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 30 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 57 31 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 57 32 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 57 33 17 17 CD work_gukk34cj2ba2hfeeqnbcodfs6m 57 34 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 35 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 57 36 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 57 37 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 57 38 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 57 39 CEPH CEPH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 40 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 57 41 Centre Centre NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 42 d’Etude d’Etude NNS work_gukk34cj2ba2hfeeqnbcodfs6m 57 43 Poly- Poly- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 44 morphisme morphisme NN work_gukk34cj2ba2hfeeqnbcodfs6m 57 45 Humain Humain NNP work_gukk34cj2ba2hfeeqnbcodfs6m 57 46 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 57 47 controls control NNS work_gukk34cj2ba2hfeeqnbcodfs6m 57 48 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 57 49 genotyped genotype VBN work_gukk34cj2ba2hfeeqnbcodfs6m 57 50 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 58 1 These these DT work_gukk34cj2ba2hfeeqnbcodfs6m 58 2 controls control NNS work_gukk34cj2ba2hfeeqnbcodfs6m 58 3 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 58 4 previously previously RB work_gukk34cj2ba2hfeeqnbcodfs6m 58 5 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 58 6 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 58 7 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 58 8 nucleotide nucleotide IN work_gukk34cj2ba2hfeeqnbcodfs6m 58 9 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 58 10 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 58 11 carriers.12 carriers.12 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 58 12 Haplotypes Haplotypes NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 58 13 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 58 14 reconstructed reconstruct VBN work_gukk34cj2ba2hfeeqnbcodfs6m 58 15 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 58 16 15 15 CD work_gukk34cj2ba2hfeeqnbcodfs6m 58 17 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 58 18 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 58 19 assuming assume VBG work_gukk34cj2ba2hfeeqnbcodfs6m 58 20 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 58 21 minimum minimum JJ work_gukk34cj2ba2hfeeqnbcodfs6m 58 22 number number NN work_gukk34cj2ba2hfeeqnbcodfs6m 58 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 58 24 recombinations recombination NNS work_gukk34cj2ba2hfeeqnbcodfs6m 58 25 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 58 26 each each DT work_gukk34cj2ba2hfeeqnbcodfs6m 58 27 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 58 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 59 1 Methods method NNS work_gukk34cj2ba2hfeeqnbcodfs6m 59 2 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 3 computing compute VBG work_gukk34cj2ba2hfeeqnbcodfs6m 59 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 5 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 6 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 8 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 59 9 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 10 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 12 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 59 13 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 14 To to TO work_gukk34cj2ba2hfeeqnbcodfs6m 59 15 estimate estimate VB work_gukk34cj2ba2hfeeqnbcodfs6m 59 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 17 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 20 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 59 21 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 59 22 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 23 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 24 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 59 25 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 59 26 used use VBD work_gukk34cj2ba2hfeeqnbcodfs6m 59 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 28 DMLE dmle NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 29 programme21 programme21 NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 30 which which WDT work_gukk34cj2ba2hfeeqnbcodfs6m 59 31 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 59 32 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 33 its -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 59 34 original original JJ work_gukk34cj2ba2hfeeqnbcodfs6m 59 35 form form NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 36 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 59 37 designed design VBN work_gukk34cj2ba2hfeeqnbcodfs6m 59 38 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 59 39 estimate estimate VB work_gukk34cj2ba2hfeeqnbcodfs6m 59 40 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 41 recombination recombination NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 42 distance distance NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 43 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 44 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 45 biallelic biallelic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 59 46 marker marker NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 47 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 59 48 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 49 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 50 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 51 based base VBN work_gukk34cj2ba2hfeeqnbcodfs6m 59 52 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 53 observed observed JJ work_gukk34cj2ba2hfeeqnbcodfs6m 59 54 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 59 55 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 59 56 supposed suppose VBN work_gukk34cj2ba2hfeeqnbcodfs6m 59 57 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 59 58 historical historical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 59 59 recombinations recombination NNS work_gukk34cj2ba2hfeeqnbcodfs6m 59 60 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 61 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 62 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 59 63 rather rather RB work_gukk34cj2ba2hfeeqnbcodfs6m 59 64 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 59 65 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 59 66 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 67 estimation estimation NN work_gukk34cj2ba2hfeeqnbcodfs6m 59 68 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 60 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 2 possibility possibility NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 4 estimating estimate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 60 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 6 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 8 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 9 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 10 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 60 11 implemented implement VBN work_gukk34cj2ba2hfeeqnbcodfs6m 60 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 13 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 14 more more RBR work_gukk34cj2ba2hfeeqnbcodfs6m 60 15 recent recent JJ work_gukk34cj2ba2hfeeqnbcodfs6m 60 16 version version NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 17 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 60 18 beta beta NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 19 0.25 0.25 CD work_gukk34cj2ba2hfeeqnbcodfs6m 60 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 60 21 released release VBN work_gukk34cj2ba2hfeeqnbcodfs6m 60 22 April April NNP work_gukk34cj2ba2hfeeqnbcodfs6m 60 23 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 60 24 1999 1999 CD work_gukk34cj2ba2hfeeqnbcodfs6m 60 25 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 60 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 28 programme programme NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 29 given give VBN work_gukk34cj2ba2hfeeqnbcodfs6m 60 30 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 31 parameters parameter NNS work_gukk34cj2ba2hfeeqnbcodfs6m 60 32 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 33 ‘ ' `` work_gukk34cj2ba2hfeeqnbcodfs6m 60 34 known know VBN work_gukk34cj2ba2hfeeqnbcodfs6m 60 35 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 60 36 recombination recombination NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 37 rate rate NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 38 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 60 39 popu- popu- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 60 40 lation lation NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 41 growth growth NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 42 rate rate NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 43 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 60 44 frequencies frequency NNS work_gukk34cj2ba2hfeeqnbcodfs6m 60 45 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 46 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 47 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 48 associated associate VBD work_gukk34cj2ba2hfeeqnbcodfs6m 60 49 marker marker NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 50 alleles alleles NNP work_gukk34cj2ba2hfeeqnbcodfs6m 60 51 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 60 52 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 60 53 ie ie FW work_gukk34cj2ba2hfeeqnbcodfs6m 60 54 identical identical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 60 55 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 56 state state NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 57 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 60 58 IBS)21 IBS)21 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 60 59 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 60 sampled sample VBN work_gukk34cj2ba2hfeeqnbcodfs6m 60 61 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 62 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 60 63 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 60 64 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 65 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 66 general general JJ work_gukk34cj2ba2hfeeqnbcodfs6m 60 67 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 68 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 60 69 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 60 70 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 71 proportion proportion NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 72 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 73 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 74 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 75 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 60 76 sampled sample VBN work_gukk34cj2ba2hfeeqnbcodfs6m 60 77 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 78 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 60 79 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 80 under under IN work_gukk34cj2ba2hfeeqnbcodfs6m 60 81 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 60 82 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 61 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 61 2 chose choose VBD work_gukk34cj2ba2hfeeqnbcodfs6m 61 3 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 4 following follow VBG work_gukk34cj2ba2hfeeqnbcodfs6m 61 5 para- para- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 61 6 meters meter NNS work_gukk34cj2ba2hfeeqnbcodfs6m 61 7 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 9 estimate estimate NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 10 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 61 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 12 recombination recombination NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 13 rate rate NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 14 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 61 15 based base VBN work_gukk34cj2ba2hfeeqnbcodfs6m 61 16 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 18 estimated estimate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 61 19 physical physical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 61 20 distance distance NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 22 630 630 CD work_gukk34cj2ba2hfeeqnbcodfs6m 61 23 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 24 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 25 D9S163 d9s163 NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 26 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 61 27 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 61 28 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 61 29 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 30 calculated calculate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 61 31 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 61 32 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 33 genomic genomic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 61 34 sequence sequence NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 35 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 61 36 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 37 BAC BAC NNP work_gukk34cj2ba2hfeeqnbcodfs6m 61 38 contig11 contig11 NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 39 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 61 40 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 41 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 61 42 distance distance NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 43 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 44 0.3 0.3 CD work_gukk34cj2ba2hfeeqnbcodfs6m 61 45 cM cM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 61 46 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 47 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 48 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 61 49 interval.9 interval.9 NNS work_gukk34cj2ba2hfeeqnbcodfs6m 61 50 These these DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 51 numbers number NNS work_gukk34cj2ba2hfeeqnbcodfs6m 61 52 led lead VBD work_gukk34cj2ba2hfeeqnbcodfs6m 61 53 us -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 61 54 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 61 55 assume assume VB work_gukk34cj2ba2hfeeqnbcodfs6m 61 56 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 57 2.1 2.1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 61 58 Mb Mb NNP work_gukk34cj2ba2hfeeqnbcodfs6m 61 59 correspond correspond VB work_gukk34cj2ba2hfeeqnbcodfs6m 61 60 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 61 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 61 62 cM cm NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 63 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 61 64 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 61 65 chromosomal chromosomal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 61 66 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 61 67 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 62 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 62 2 general general JJ work_gukk34cj2ba2hfeeqnbcodfs6m 62 3 approximation approximation NN work_gukk34cj2ba2hfeeqnbcodfs6m 62 4 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 62 5 Mb mb NN work_gukk34cj2ba2hfeeqnbcodfs6m 62 6 corresponding correspond VBG work_gukk34cj2ba2hfeeqnbcodfs6m 62 7 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 62 8 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 62 9 cM cM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 62 10 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 62 11 used use VBN work_gukk34cj2ba2hfeeqnbcodfs6m 62 12 as as RB work_gukk34cj2ba2hfeeqnbcodfs6m 62 13 well well RB work_gukk34cj2ba2hfeeqnbcodfs6m 62 14 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 63 1 Population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 2 growth growth NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 3 rate rate NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 4 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 63 5 exponential exponential NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 6 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 63 7 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 63 8 estimated estimate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 63 9 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 63 10 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 63 11 0.070 0.070 CD work_gukk34cj2ba2hfeeqnbcodfs6m 63 12 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 63 13 actual actual JJ work_gukk34cj2ba2hfeeqnbcodfs6m 63 14 later later RB work_gukk34cj2ba2hfeeqnbcodfs6m 63 15 historical historical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 63 16 census census NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 17 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 63 18 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 63 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 63 20 18th 18th JJ work_gukk34cj2ba2hfeeqnbcodfs6m 63 21 century century NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 63 23 assuming assume VBG work_gukk34cj2ba2hfeeqnbcodfs6m 63 24 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 63 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 63 26 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 27 reaches reach VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 63 28 far far RB work_gukk34cj2ba2hfeeqnbcodfs6m 63 29 beyond beyond IN work_gukk34cj2ba2hfeeqnbcodfs6m 63 30 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 63 31 start start NN work_gukk34cj2ba2hfeeqnbcodfs6m 63 32 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 63 33 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 63 34 Common Common NNP work_gukk34cj2ba2hfeeqnbcodfs6m 63 35 Era Era NNP work_gukk34cj2ba2hfeeqnbcodfs6m 63 36 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 64 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 64 2 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 64 3 chromosome chromosome NN work_gukk34cj2ba2hfeeqnbcodfs6m 64 4 associated associate VBD work_gukk34cj2ba2hfeeqnbcodfs6m 64 5 allele allele NNP work_gukk34cj2ba2hfeeqnbcodfs6m 64 6 frequencies frequency NNS work_gukk34cj2ba2hfeeqnbcodfs6m 64 7 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 64 8 directly directly RB work_gukk34cj2ba2hfeeqnbcodfs6m 64 9 calculated calculate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 64 10 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 64 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 64 12 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 64 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 64 14 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 64 15 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 64 16 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 64 17 frequencies frequencie VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 64 18 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 64 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 64 20 healthy healthy JJ work_gukk34cj2ba2hfeeqnbcodfs6m 64 21 parental parental JJ work_gukk34cj2ba2hfeeqnbcodfs6m 64 22 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 64 23 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 65 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 65 2 proportion proportion NN work_gukk34cj2ba2hfeeqnbcodfs6m 65 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 65 4 sampled sample VBN work_gukk34cj2ba2hfeeqnbcodfs6m 65 5 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 65 6 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 65 7 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 65 8 calculated calculate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 65 9 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 65 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 65 11 frequency frequency JJ work_gukk34cj2ba2hfeeqnbcodfs6m 65 12 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 65 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 65 14 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 65 15 blood blood NN work_gukk34cj2ba2hfeeqnbcodfs6m 65 16 donors donor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 65 17 ’ ’ POS work_gukk34cj2ba2hfeeqnbcodfs6m 65 18 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 65 19 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 65 20 10/ 10/ CD work_gukk34cj2ba2hfeeqnbcodfs6m 65 21 845 845 CD work_gukk34cj2ba2hfeeqnbcodfs6m 65 22 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 65 23 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 65 24 taking take VBG work_gukk34cj2ba2hfeeqnbcodfs6m 65 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 65 26 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 65 27 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 65 28 size size NN work_gukk34cj2ba2hfeeqnbcodfs6m 65 29 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 65 30 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 65 31 million million CD work_gukk34cj2ba2hfeeqnbcodfs6m 65 32 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 66 1 Two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 66 2 million million CD work_gukk34cj2ba2hfeeqnbcodfs6m 66 3 Monte Monte NNP work_gukk34cj2ba2hfeeqnbcodfs6m 66 4 Carlo Carlo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 66 5 replicates replicate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 66 6 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 66 7 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 66 8 seeds seed NNS work_gukk34cj2ba2hfeeqnbcodfs6m 66 9 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 66 10 computed compute VBN work_gukk34cj2ba2hfeeqnbcodfs6m 66 11 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 66 13 2.1 2.1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 66 14 Mb Mb NNP work_gukk34cj2ba2hfeeqnbcodfs6m 66 15 correspondence correspondence NN work_gukk34cj2ba2hfeeqnbcodfs6m 66 16 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 66 17 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 66 18 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 66 19 average average JJ work_gukk34cj2ba2hfeeqnbcodfs6m 66 20 likelihoods likelihood NNS work_gukk34cj2ba2hfeeqnbcodfs6m 66 21 taken take VBN work_gukk34cj2ba2hfeeqnbcodfs6m 66 22 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 66 23 represent represent VB work_gukk34cj2ba2hfeeqnbcodfs6m 66 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 66 25 final final JJ work_gukk34cj2ba2hfeeqnbcodfs6m 66 26 values value NNS work_gukk34cj2ba2hfeeqnbcodfs6m 66 27 because because IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 28 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 29 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 66 30 poorer poor JJR work_gukk34cj2ba2hfeeqnbcodfs6m 66 31 convergence convergence NN work_gukk34cj2ba2hfeeqnbcodfs6m 66 32 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 33 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 66 34 definite definite JJ work_gukk34cj2ba2hfeeqnbcodfs6m 66 35 maximum maximum NN work_gukk34cj2ba2hfeeqnbcodfs6m 66 36 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 37 compared compare VBN work_gukk34cj2ba2hfeeqnbcodfs6m 66 38 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 39 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 66 40 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 66 41 Mb mb NN work_gukk34cj2ba2hfeeqnbcodfs6m 66 42 correspondence correspondence NN work_gukk34cj2ba2hfeeqnbcodfs6m 66 43 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 44 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 66 45 length length NN work_gukk34cj2ba2hfeeqnbcodfs6m 66 46 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 66 47 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 66 48 cM cM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 66 49 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 66 50 where where WRB work_gukk34cj2ba2hfeeqnbcodfs6m 66 51 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 66 52 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 66 53 million million CD work_gukk34cj2ba2hfeeqnbcodfs6m 66 54 replicates replicate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 66 55 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 66 56 used use VBN work_gukk34cj2ba2hfeeqnbcodfs6m 66 57 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 67 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 67 2 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 67 3 computed compute VBD work_gukk34cj2ba2hfeeqnbcodfs6m 67 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 67 5 means mean NNS work_gukk34cj2ba2hfeeqnbcodfs6m 67 6 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 67 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 67 8 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 67 9 moments moment NNS work_gukk34cj2ba2hfeeqnbcodfs6m 67 10 estimator estimator NN work_gukk34cj2ba2hfeeqnbcodfs6m 67 11 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 67 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 67 13 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 67 14 recent recent JJ work_gukk34cj2ba2hfeeqnbcodfs6m 67 15 ancestor ancestor NN work_gukk34cj2ba2hfeeqnbcodfs6m 67 16 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 67 17 TMRCA)22 TMRCA)22 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 67 18 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 67 19 evaluate evaluate VB work_gukk34cj2ba2hfeeqnbcodfs6m 67 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 67 21 agreement agreement NN work_gukk34cj2ba2hfeeqnbcodfs6m 67 22 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 67 23 DMLE dmle NN work_gukk34cj2ba2hfeeqnbcodfs6m 67 24 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 67 25 estimates estimate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 67 26 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 68 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 68 2 did do VBD work_gukk34cj2ba2hfeeqnbcodfs6m 68 3 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 68 4 apply apply VB work_gukk34cj2ba2hfeeqnbcodfs6m 68 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 68 6 correction correction NN work_gukk34cj2ba2hfeeqnbcodfs6m 68 7 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 8 suggested suggest VBN work_gukk34cj2ba2hfeeqnbcodfs6m 68 9 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 10 Labuda Labuda NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 11 et et FW work_gukk34cj2ba2hfeeqnbcodfs6m 68 12 al.23 al.23 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 13 Markers Markers NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 68 14 TESK1 tesk1 FW work_gukk34cj2ba2hfeeqnbcodfs6m 68 15 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 68 16 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 68 17 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 18 SSCP SSCP NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 68 19 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 68 20 delG delg NN work_gukk34cj2ba2hfeeqnbcodfs6m 68 21 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 68 22 D4S D4S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 23 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 68 24 AC1 AC1 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 25 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 68 26 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 68 27 XL1S XL1S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 28 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 68 29 selected select VBN work_gukk34cj2ba2hfeeqnbcodfs6m 68 30 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 31 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 68 32 estimation estimation NN work_gukk34cj2ba2hfeeqnbcodfs6m 68 33 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 68 34 since since IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 35 they -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 68 36 had have VBD work_gukk34cj2ba2hfeeqnbcodfs6m 68 37 more more JJR work_gukk34cj2ba2hfeeqnbcodfs6m 68 38 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 39 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 68 40 instance instance NN work_gukk34cj2ba2hfeeqnbcodfs6m 68 41 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 42 presumably presumably RB work_gukk34cj2ba2hfeeqnbcodfs6m 68 43 non- non- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 44 ancestral ancestral NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 45 allele allele NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 46 presented present VBN work_gukk34cj2ba2hfeeqnbcodfs6m 68 47 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 48 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 68 49 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 68 50 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 68 51 disease disease NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 52 chro- chro- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 68 53 mosomes mosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 68 54 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 69 1 However however RB work_gukk34cj2ba2hfeeqnbcodfs6m 69 2 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 69 3 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 69 4 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 69 5 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 69 6 centromeric centromeric JJ work_gukk34cj2ba2hfeeqnbcodfs6m 69 7 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 69 8 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 9 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 69 10 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 11 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 69 12 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 69 13 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 69 14 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 15 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 16 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 17 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 18 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 19 441 441 CD work_gukk34cj2ba2hfeeqnbcodfs6m 69 20 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 21 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 22 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 23 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 24 Genetics Genetics NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 69 25 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 69 26 CCS CCS NNP work_gukk34cj2ba2hfeeqnbcodfs6m 69 27 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 69 28 TG2S TG2S NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 69 29 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 69 30 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 69 31 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 69 32 included include VBN work_gukk34cj2ba2hfeeqnbcodfs6m 69 33 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 34 any any DT work_gukk34cj2ba2hfeeqnbcodfs6m 69 35 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 36 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 69 37 calcula- calcula- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 69 38 tions tion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 69 39 because because IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 40 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 41 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 69 42 obvious obvious JJ work_gukk34cj2ba2hfeeqnbcodfs6m 69 43 recombination recombination NN work_gukk34cj2ba2hfeeqnbcodfs6m 69 44 hotspot hotspot NN work_gukk34cj2ba2hfeeqnbcodfs6m 69 45 separating separate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 69 46 them -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 69 47 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 48 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 69 49 rest rest NN work_gukk34cj2ba2hfeeqnbcodfs6m 69 50 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 69 51 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 69 52 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 69 53 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 70 1 Results result NNS work_gukk34cj2ba2hfeeqnbcodfs6m 70 2 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 70 3 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 70 4 segregate segregate VBP work_gukk34cj2ba2hfeeqnbcodfs6m 70 5 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 6 specific specific JJ work_gukk34cj2ba2hfeeqnbcodfs6m 70 7 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 70 8 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 70 10 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 70 11 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 12 Approximately approximately RB work_gukk34cj2ba2hfeeqnbcodfs6m 70 13 160 160 CD work_gukk34cj2ba2hfeeqnbcodfs6m 70 14 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 70 15 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 16 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 17 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 70 18 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 19 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 70 20 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 70 21 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 70 22 diagnosed diagnose VBN work_gukk34cj2ba2hfeeqnbcodfs6m 70 23 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 24 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 70 25 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 70 26 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 70 27 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 70 28 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 70 29 patient patient NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 30 registry).2 registry).2 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 70 31 After after IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 32 finding find VBG work_gukk34cj2ba2hfeeqnbcodfs6m 70 33 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 70 34 first first JJ work_gukk34cj2ba2hfeeqnbcodfs6m 70 35 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 70 36 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 70 37 causing cause VBG work_gukk34cj2ba2hfeeqnbcodfs6m 70 38 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 70 39 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 40 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 70 41 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 70 42 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 70 43 continued continue VBD work_gukk34cj2ba2hfeeqnbcodfs6m 70 44 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 70 45 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 46 search search NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 47 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 48 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 70 49 rest rest NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 50 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 51 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 70 52 115 115 CD work_gukk34cj2ba2hfeeqnbcodfs6m 70 53 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 70 54 patient patient NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 55 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 70 56 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 70 57 19 19 CD work_gukk34cj2ba2hfeeqnbcodfs6m 70 58 multiplex multiplex NN work_gukk34cj2ba2hfeeqnbcodfs6m 70 59 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 70 60 72 72 CD work_gukk34cj2ba2hfeeqnbcodfs6m 70 61 uniplex uniplex JJ work_gukk34cj2ba2hfeeqnbcodfs6m 70 62 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 70 63 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 71 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 71 2 found find VBD work_gukk34cj2ba2hfeeqnbcodfs6m 71 3 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 71 4 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 71 5 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 71 6 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 71 7 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 71 8 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 71 9 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 71 10 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 71 11 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 71 12 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 71 13 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 71 14 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 71 15 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 71 16 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 71 17 homozygous homozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 71 18 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 71 19 74 74 CD work_gukk34cj2ba2hfeeqnbcodfs6m 71 20 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 71 21 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 71 22 Table table NN work_gukk34cj2ba2hfeeqnbcodfs6m 71 23 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 71 24 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 71 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 72 1 All all DT work_gukk34cj2ba2hfeeqnbcodfs6m 72 2 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 72 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 72 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 72 5 remaining remain VBG work_gukk34cj2ba2hfeeqnbcodfs6m 72 6 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 72 7 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 72 8 compound compound NN work_gukk34cj2ba2hfeeqnbcodfs6m 72 9 heterozygotes heterozygote NNS work_gukk34cj2ba2hfeeqnbcodfs6m 72 10 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 72 11 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 72 12 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 72 13 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 72 14 represented represent VBD work_gukk34cj2ba2hfeeqnbcodfs6m 72 15 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 72 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 72 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 72 18 four four CD work_gukk34cj2ba2hfeeqnbcodfs6m 72 19 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 72 20 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 72 21 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 72 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 72 23 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 72 24 allele allele NNP work_gukk34cj2ba2hfeeqnbcodfs6m 72 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 73 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 73 2 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 73 3 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 73 4 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 73 5 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 73 6 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 73 7 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 73 8 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 73 9 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 73 10 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 73 11 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 73 12 G262 G262 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 73 13 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 73 14 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 73 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 73 16 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 73 17 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 73 18 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 73 19 13 13 CD work_gukk34cj2ba2hfeeqnbcodfs6m 73 20 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 73 21 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 74 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 74 2 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 74 3 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 74 4 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 74 5 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 74 6 detected detect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 74 7 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 74 8 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 74 9 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 74 10 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 74 11 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 74 12 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 74 13 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 74 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 74 15 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 74 16 shown show VBN work_gukk34cj2ba2hfeeqnbcodfs6m 74 17 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 74 18 Table table NN work_gukk34cj2ba2hfeeqnbcodfs6m 74 19 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 74 20 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 75 1 All all DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 75 3 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 75 4 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 75 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 6 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 7 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 75 8 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 75 9 resided reside VBD work_gukk34cj2ba2hfeeqnbcodfs6m 75 10 either either CC work_gukk34cj2ba2hfeeqnbcodfs6m 75 11 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 75 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 13 evolutionally evolutionally RB work_gukk34cj2ba2hfeeqnbcodfs6m 75 14 conserved conserve VBN work_gukk34cj2ba2hfeeqnbcodfs6m 75 15 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 75 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 75 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 18 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 75 19 transcript24,25 transcript24,25 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 75 20 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 75 21 disrupted disrupt VBD work_gukk34cj2ba2hfeeqnbcodfs6m 75 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 23 function function NN work_gukk34cj2ba2hfeeqnbcodfs6m 75 24 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 75 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 26 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 75 27 region.12 region.12 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 75 28 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 29 G262 G262 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 75 30 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 75 31 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 75 32 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 75 33 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 75 34 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 75 35 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 75 36 173 173 CD work_gukk34cj2ba2hfeeqnbcodfs6m 75 37 anonymous anonymous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 38 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 39 blood blood NN work_gukk34cj2ba2hfeeqnbcodfs6m 75 40 donors donor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 75 41 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 75 42 nor nor CC work_gukk34cj2ba2hfeeqnbcodfs6m 75 43 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 75 44 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 45 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 46 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 47 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 75 48 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 75 49 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 75 50 120 120 CD work_gukk34cj2ba2hfeeqnbcodfs6m 75 51 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 75 52 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 75 53 controls control NNS work_gukk34cj2ba2hfeeqnbcodfs6m 75 54 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 75 55 160 160 CD work_gukk34cj2ba2hfeeqnbcodfs6m 75 56 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 57 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 58 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 75 59 controls control NNS work_gukk34cj2ba2hfeeqnbcodfs6m 75 60 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 76 1 Ten ten CD work_gukk34cj2ba2hfeeqnbcodfs6m 76 2 heterozygous heterozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 76 3 carriers carrier NNS work_gukk34cj2ba2hfeeqnbcodfs6m 76 4 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 76 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 76 6 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 76 7 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 76 8 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 76 9 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 76 10 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 76 11 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 76 12 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 76 13 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 76 14 845 845 CD work_gukk34cj2ba2hfeeqnbcodfs6m 76 15 anonymous anonymous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 76 16 blood blood NN work_gukk34cj2ba2hfeeqnbcodfs6m 76 17 donors donor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 76 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 76 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 76 20 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 76 21 Red Red NNP work_gukk34cj2ba2hfeeqnbcodfs6m 76 22 Cross Cross NNP work_gukk34cj2ba2hfeeqnbcodfs6m 76 23 Blood Blood NNP work_gukk34cj2ba2hfeeqnbcodfs6m 76 24 Transfusion Transfusion NNP work_gukk34cj2ba2hfeeqnbcodfs6m 76 25 Service Service NNP work_gukk34cj2ba2hfeeqnbcodfs6m 76 26 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 76 27 representing represent VBG work_gukk34cj2ba2hfeeqnbcodfs6m 76 28 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 76 29 geographic geographic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 76 30 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 76 31 distribution distribution NN work_gukk34cj2ba2hfeeqnbcodfs6m 76 32 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 76 33 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 76 34 beginning beginning NN work_gukk34cj2ba2hfeeqnbcodfs6m 76 35 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 76 36 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 76 37 20th 20th JJ work_gukk34cj2ba2hfeeqnbcodfs6m 76 38 century century NN work_gukk34cj2ba2hfeeqnbcodfs6m 76 39 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 77 1 When when WRB work_gukk34cj2ba2hfeeqnbcodfs6m 77 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 77 3 DNA dna NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 4 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 5 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 77 7 parents parent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 8 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 77 9 available available JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 11 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 77 12 genotyped genotype VBD work_gukk34cj2ba2hfeeqnbcodfs6m 77 13 them -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 77 14 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 77 15 reconstructed reconstruct VBN work_gukk34cj2ba2hfeeqnbcodfs6m 77 16 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 17 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 18 segregating segregate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 77 19 Table table NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 20 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 21 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 22 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 23 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 24 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 25 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 77 26 foreign foreign JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 27 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 28 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 29 Number number NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 30 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 31 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 32 Mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 33 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 34 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 35 Nationality Nationality NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 36 Uniplex Uniplex NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 37 Multiplex Multiplex NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 38 70G 70G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 39 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 40 Ga Ga NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 41 Finnish Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 42 59d 59d CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 43 15 15 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 44 70G/262Tb 70g/262tb CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 45 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 46 9 9 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 47 4 4 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 48 70G/211 70g/211 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 49 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 50 Finnish Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 51 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 52 70G/154 70g/154 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 53 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 54 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 55 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 56 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 57 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 58 dupTACTCTGTGA dupTACTCTGTGA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 59 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 60 713c 713c CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 61 Finnish Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 62 2 2 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 63 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 64 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 65 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 66 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 67 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 68 Canadian canadian JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 69 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 70 Dutch dutch JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 71 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 72 Turkish turkish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 73 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 74 English English NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 75 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 76 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 77 Amish Amish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 78 12 12 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 79 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 80 70G/63 70g/63 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 81 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 82 Australian Australian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 83 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 84 70G/79A 70g/79a CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 85 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 86 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 87 70G/180A 70g/180a CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 88 Mexican Mexican NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 89 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 90 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 91 70G/182C 70g/182c CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 92 Dutch Dutch NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 93 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 77 94 English English NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 95 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 96 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 97 70G/211 70g/211 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 98 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 99 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 100 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 101 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 102 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 103 dup dup NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 104 TCTGTGA TCTGTGA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 105 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 106 713 713 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 107 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 108 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 109 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 110 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 111 dup dup NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 112 AAGCTGAG AAGCTGAG NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 113 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 114 76 76 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 115 Mexican Mexican NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 116 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 117 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 118 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 119 dup dup NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 120 TGAAGCTGAG TGAAGCTGAG NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 121 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 122 76 76 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 123 French French NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 124 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 125 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 126 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 127 ins in NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 128 CCTGAG CCTGAG NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 129 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 130 76c 76c CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 131 German german JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 132 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 133 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 134 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 135 dup dup NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 136 AAGCTGAGGACGTG AAGCTGAGGACGTG NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 137 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 138 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 139 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 140 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 141 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 142 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 143 dup dup NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 144 GGACGTGGTT GGACGTGGTT NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 145 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 146 4 4 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 147 Brazilian Brazilian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 148 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 149 70G 70G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 150 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 151 ins in NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 152 TTCCGCCT TTCCGCCT VBN work_gukk34cj2ba2hfeeqnbcodfs6m 77 153 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 154 57 57 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 155 French french JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 156 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 157 70G 70g CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 158 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 159 dup dup NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 160 TG TG NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 161 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 162 98c 98c CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 163 Canadian Canadian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 164 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 165 118G/214 118g/214 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 166 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 167 German german JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 168 126T 126T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 169 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 170 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 171 Arabian Arabian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 172 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 173 146A 146a CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 174 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 175 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 176 Chinese chinese JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 177 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 178 152G/243 152g/243 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 179 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 180 Canadian canadian JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 181 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 182 193A/242 193a/242 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 183 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 184 Canadian Canadian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 185 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 186 195T/238 195t/238 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 187 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 188 Israelis Israelis NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 77 189 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 190 195T/242 195t/242 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 191 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 192 Brazilian Brazilian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 193 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 194 211G/230 211g/230 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 195 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 196 Polish Polish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 197 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 198 236G/238 236g/238 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 199 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 200 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 201 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 202 261T 261t CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 203 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 204 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 205 Israelis Israelis NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 77 206 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 207 264A 264a CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 208 / / , work_gukk34cj2ba2hfeeqnbcodfs6m 77 209 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 77 210 Austrian Austrian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 211 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 212 4T 4t CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 213 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 214 del del NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 215 AG AG NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 216 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 217 94 94 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 218 English English NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 219 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 220 193A 193a CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 221 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 222 dup dup NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 223 English English NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 224 TCTGTGAAGCTGAGGAC TCTGTGAAGCTGAGGAC NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 225 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 226 73c 73c CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 227 195T 195t CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 228 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 229 ins in NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 230 GGACGTGGTT GGACGTGGTT NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 231 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 232 74 74 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 233 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 234 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 235 dup dup NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 236 TG TG NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 237 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 238 98 98 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 239 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 77 240 dup dup NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 241 TG TG NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 242 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 243 98 98 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 244 Turkish turkish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 245 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 246 dup dup NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 247 TG tg NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 248 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 249 98/2 98/2 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 250 times time NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 251 dup dup NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 252 Swiss Swiss NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 253 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 77 254 ACTACTCTGTGAAGC ACTACTCTGTGAAGC NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 255 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 256 710c 710c NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 257 Many many JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 258 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 259 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 77 260 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 77 261 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 77 262 represent represent VBP work_gukk34cj2ba2hfeeqnbcodfs6m 77 263 evidence evidence NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 264 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 77 265 Caucasian caucasian JJ work_gukk34cj2ba2hfeeqnbcodfs6m 77 266 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 267 history history NN work_gukk34cj2ba2hfeeqnbcodfs6m 77 268 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 78 1 aincluding ainclude VBG work_gukk34cj2ba2hfeeqnbcodfs6m 78 2 42 42 CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 3 previously previously RB work_gukk34cj2ba2hfeeqnbcodfs6m 78 4 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 78 5 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 78 6 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 78 7 30 30 CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 8 uniplex uniplex CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 9 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 78 10 12 12 CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 11 multiplex multiplex NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 12 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 78 13 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 78 14 bincluding binclude VBG work_gukk34cj2ba2hfeeqnbcodfs6m 78 15 six six CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 16 previously previously RB work_gukk34cj2ba2hfeeqnbcodfs6m 78 17 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 78 18 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 78 19 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 78 20 five five CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 21 uniplex uniplex NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 78 23 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 24 multiplex multiplex NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 25 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 78 26 ; ; , work_gukk34cj2ba2hfeeqnbcodfs6m 78 27 cpreviously cpreviously RB work_gukk34cj2ba2hfeeqnbcodfs6m 78 28 reported report VBD work_gukk34cj2ba2hfeeqnbcodfs6m 78 29 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 30 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 78 31 families;12 families;12 NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 32 dincluding dinclude VBG work_gukk34cj2ba2hfeeqnbcodfs6m 78 33 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 34 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 78 35 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 78 36 uniparental uniparental JJ work_gukk34cj2ba2hfeeqnbcodfs6m 78 37 disomy disomy NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 38 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 78 39 chromosome chromosome NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 40 9 9 CD work_gukk34cj2ba2hfeeqnbcodfs6m 78 41 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 78 42 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 78 43 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 78 44 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 78 45 B B NNP work_gukk34cj2ba2hfeeqnbcodfs6m 78 46 in20 in20 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 78 47 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 78 48 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 79 1 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 79 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 79 4 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 79 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 79 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 79 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 8 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 9 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 12 442 442 CD work_gukk34cj2ba2hfeeqnbcodfs6m 79 13 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 14 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 79 16 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 17 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 18 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 79 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 79 20 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 79 21 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 79 22 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 79 23 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 80 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 80 2 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 80 3 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 4 always always RB work_gukk34cj2ba2hfeeqnbcodfs6m 80 5 segregated segregate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 80 6 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 80 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 80 8 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 80 9 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 80 10 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 11 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 80 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 80 13 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 80 14 study),12 study),12 NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 80 16 shortest short JJS work_gukk34cj2ba2hfeeqnbcodfs6m 80 17 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 18 being be VBG work_gukk34cj2ba2hfeeqnbcodfs6m 80 19 less less JJR work_gukk34cj2ba2hfeeqnbcodfs6m 80 20 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 80 21 29 29 CD work_gukk34cj2ba2hfeeqnbcodfs6m 80 22 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 23 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 80 24 length length NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 25 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 80 26 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 80 27 D13 D13 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 80 28 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 80 29 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 80 30 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 31 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 32 poly- poly- NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 33 morphism morphism NNP work_gukk34cj2ba2hfeeqnbcodfs6m 80 34 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 80 35 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 80 36 first first JJ work_gukk34cj2ba2hfeeqnbcodfs6m 80 37 exon exon NN work_gukk34cj2ba2hfeeqnbcodfs6m 80 38 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 80 39 MN MN NNP work_gukk34cj2ba2hfeeqnbcodfs6m 80 40 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 80 41 CA9 CA9 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 80 42 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 80 43 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 80 44 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 80 45 shown show VBN work_gukk34cj2ba2hfeeqnbcodfs6m 80 46 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 80 47 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 81 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 81 2 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 81 3 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 81 4 G262 G262 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 81 5 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 81 6 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 81 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 81 8 10 10 CD work_gukk34cj2ba2hfeeqnbcodfs6m 81 9 bp bp NN work_gukk34cj2ba2hfeeqnbcodfs6m 81 10 duplication duplication NN work_gukk34cj2ba2hfeeqnbcodfs6m 81 11 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 81 12 713 713 CD work_gukk34cj2ba2hfeeqnbcodfs6m 81 13 segregated segregated JJ work_gukk34cj2ba2hfeeqnbcodfs6m 81 14 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 81 15 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 81 16 own own JJ work_gukk34cj2ba2hfeeqnbcodfs6m 81 17 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 81 18 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 81 19 depicted depict VBN work_gukk34cj2ba2hfeeqnbcodfs6m 81 20 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 81 21 Figure Figure NNP work_gukk34cj2ba2hfeeqnbcodfs6m 81 22 1A. 1a. CD work_gukk34cj2ba2hfeeqnbcodfs6m 82 1 All all DT work_gukk34cj2ba2hfeeqnbcodfs6m 82 2 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 82 3 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 82 4 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 82 5 more more JJR work_gukk34cj2ba2hfeeqnbcodfs6m 82 6 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 82 7 200 200 CD work_gukk34cj2ba2hfeeqnbcodfs6m 82 8 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 82 9 Figure Figure NNP work_gukk34cj2ba2hfeeqnbcodfs6m 82 10 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 82 11 Haplotype Haplotype NNP work_gukk34cj2ba2hfeeqnbcodfs6m 82 12 analyses analysis NNS work_gukk34cj2ba2hfeeqnbcodfs6m 82 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 82 14 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 82 15 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 82 16 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 82 17 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 82 18 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 82 19 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 82 20 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 82 21 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 82 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 83 1 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 83 2 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 83 3 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 83 4 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 83 5 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 83 6 segregating segregate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 83 7 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 83 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 83 9 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 83 10 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 83 11 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 83 12 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 83 13 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 83 14 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 83 15 that that DT work_gukk34cj2ba2hfeeqnbcodfs6m 83 16 segregating segregating NN work_gukk34cj2ba2hfeeqnbcodfs6m 83 17 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 83 18 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 83 19 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 83 20 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 83 21 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 83 22 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 83 23 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 83 24 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 83 25 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 83 26 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 83 27 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 83 28 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 83 29 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 83 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 84 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 84 2 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 84 3 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 84 4 determined determine VBN work_gukk34cj2ba2hfeeqnbcodfs6m 84 5 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 84 6 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 84 7 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 84 8 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 84 9 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 84 10 depicted depict VBN work_gukk34cj2ba2hfeeqnbcodfs6m 84 11 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 84 12 blue blue NNP work_gukk34cj2ba2hfeeqnbcodfs6m 84 13 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 85 1 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 85 2 B b NN work_gukk34cj2ba2hfeeqnbcodfs6m 85 3 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 85 4 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 85 5 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 85 6 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 85 7 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 85 8 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 85 9 segregating segregate VBG work_gukk34cj2ba2hfeeqnbcodfs6m 85 10 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 85 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 85 12 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 85 13 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 85 14 show show VBP work_gukk34cj2ba2hfeeqnbcodfs6m 85 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 85 16 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 85 17 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 85 18 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 85 19 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 86 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 86 2 four four CD work_gukk34cj2ba2hfeeqnbcodfs6m 86 3 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 86 4 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 86 5 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 86 6 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 86 7 reconstructed reconstruct VBN work_gukk34cj2ba2hfeeqnbcodfs6m 86 8 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 86 9 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 86 10 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 86 11 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 86 12 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 86 13 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 86 14 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 86 15 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 86 16 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 86 17 CEPH CEPH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 86 18 controls control NNS work_gukk34cj2ba2hfeeqnbcodfs6m 86 19 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 87 1 On on IN work_gukk34cj2ba2hfeeqnbcodfs6m 87 2 top top NN work_gukk34cj2ba2hfeeqnbcodfs6m 87 3 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 87 4 shown show VBN work_gukk34cj2ba2hfeeqnbcodfs6m 87 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 87 6 distances distance NNS work_gukk34cj2ba2hfeeqnbcodfs6m 87 7 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 87 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 87 9 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 87 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 87 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 87 12 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 87 13 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 87 14 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 87 15 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 87 16 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 88 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 88 2 telomere telomere NN work_gukk34cj2ba2hfeeqnbcodfs6m 88 3 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 88 4 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 88 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 88 6 left left NN work_gukk34cj2ba2hfeeqnbcodfs6m 88 7 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 89 1 N n CD work_gukk34cj2ba2hfeeqnbcodfs6m 89 2 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 89 3 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 89 4 undetermined undetermined JJ work_gukk34cj2ba2hfeeqnbcodfs6m 89 5 allele allele NN work_gukk34cj2ba2hfeeqnbcodfs6m 89 6 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 90 1 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 90 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 90 4 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 90 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 90 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 90 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 8 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 9 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 12 443 443 CD work_gukk34cj2ba2hfeeqnbcodfs6m 90 13 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 14 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 90 16 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 90 17 Genetics Genetics NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 90 18 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 90 19 length length NN work_gukk34cj2ba2hfeeqnbcodfs6m 90 20 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 90 21 longer long JJR work_gukk34cj2ba2hfeeqnbcodfs6m 90 22 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 90 23 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 90 24 large large JJ work_gukk34cj2ba2hfeeqnbcodfs6m 90 25 proportion proportion NN work_gukk34cj2ba2hfeeqnbcodfs6m 90 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 90 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 90 28 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 90 29 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 90 30 suggesting suggest VBG work_gukk34cj2ba2hfeeqnbcodfs6m 90 31 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 90 32 more more RBR work_gukk34cj2ba2hfeeqnbcodfs6m 90 33 recent recent JJ work_gukk34cj2ba2hfeeqnbcodfs6m 90 34 occurrence occurrence NN work_gukk34cj2ba2hfeeqnbcodfs6m 90 35 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 90 36 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 90 37 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 90 38 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 91 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 91 2 birthplaces birthplace NNS work_gukk34cj2ba2hfeeqnbcodfs6m 91 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 91 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 91 5 great great JJ work_gukk34cj2ba2hfeeqnbcodfs6m 91 6 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 91 7 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 91 8 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 91 9 107 107 CD work_gukk34cj2ba2hfeeqnbcodfs6m 91 10 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 91 11 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 91 12 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 91 13 reported2 reported2 NN work_gukk34cj2ba2hfeeqnbcodfs6m 91 14 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 91 15 reside reside VB work_gukk34cj2ba2hfeeqnbcodfs6m 91 16 relatively relatively RB work_gukk34cj2ba2hfeeqnbcodfs6m 91 17 evenly evenly RB work_gukk34cj2ba2hfeeqnbcodfs6m 91 18 both both CC work_gukk34cj2ba2hfeeqnbcodfs6m 91 19 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 91 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 91 21 early early JJ work_gukk34cj2ba2hfeeqnbcodfs6m 91 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 91 23 late late JJ work_gukk34cj2ba2hfeeqnbcodfs6m 91 24 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 91 25 regions region NNS work_gukk34cj2ba2hfeeqnbcodfs6m 91 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 91 27 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 91 28 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 91 29 Figure Figure NNP work_gukk34cj2ba2hfeeqnbcodfs6m 91 30 2A 2a NN work_gukk34cj2ba2hfeeqnbcodfs6m 91 31 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 91 32 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 92 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 92 2 separately separately RB work_gukk34cj2ba2hfeeqnbcodfs6m 92 3 collected collect VBD work_gukk34cj2ba2hfeeqnbcodfs6m 92 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 92 5 information information NN work_gukk34cj2ba2hfeeqnbcodfs6m 92 6 about about IN work_gukk34cj2ba2hfeeqnbcodfs6m 92 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 92 8 great great JJ work_gukk34cj2ba2hfeeqnbcodfs6m 92 9 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 92 10 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 92 11 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 92 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 92 13 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 92 14 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 92 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 92 16 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 92 17 muta- muta- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 92 18 tions tion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 92 19 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 92 20 plotted plot VBD work_gukk34cj2ba2hfeeqnbcodfs6m 92 21 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 92 22 birthplaces birthplace NNS work_gukk34cj2ba2hfeeqnbcodfs6m 92 23 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 92 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 92 25 map map NN work_gukk34cj2ba2hfeeqnbcodfs6m 92 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 92 27 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 92 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 93 1 Grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 93 2 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 93 3 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 93 4 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 93 5 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 93 6 carriers carrier NNS work_gukk34cj2ba2hfeeqnbcodfs6m 93 7 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 93 8 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 93 9 more more RBR work_gukk34cj2ba2hfeeqnbcodfs6m 93 10 often often RB work_gukk34cj2ba2hfeeqnbcodfs6m 93 11 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 93 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 93 13 late late JJ work_gukk34cj2ba2hfeeqnbcodfs6m 93 14 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 93 15 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 93 16 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 93 17 Figure figure NN work_gukk34cj2ba2hfeeqnbcodfs6m 93 18 2B 2B NNS work_gukk34cj2ba2hfeeqnbcodfs6m 93 19 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 93 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 93 21 whereas whereas IN work_gukk34cj2ba2hfeeqnbcodfs6m 93 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 93 23 birthplaces birthplace NNS work_gukk34cj2ba2hfeeqnbcodfs6m 93 24 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 93 25 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 93 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 93 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 93 28 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 93 29 muta- muta- NN work_gukk34cj2ba2hfeeqnbcodfs6m 93 30 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 93 31 carriers carrier NNS work_gukk34cj2ba2hfeeqnbcodfs6m 93 32 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 93 33 distributed distribute VBN work_gukk34cj2ba2hfeeqnbcodfs6m 93 34 more more RBR work_gukk34cj2ba2hfeeqnbcodfs6m 93 35 evenly evenly RB work_gukk34cj2ba2hfeeqnbcodfs6m 93 36 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 93 37 both both CC work_gukk34cj2ba2hfeeqnbcodfs6m 93 38 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 93 39 early early JJ work_gukk34cj2ba2hfeeqnbcodfs6m 93 40 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 93 41 late late JJ work_gukk34cj2ba2hfeeqnbcodfs6m 93 42 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 93 43 regions region NNS work_gukk34cj2ba2hfeeqnbcodfs6m 93 44 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 94 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 94 2 distribution distribution NN work_gukk34cj2ba2hfeeqnbcodfs6m 94 3 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 94 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 94 5 birth- birth- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 94 6 places place NNS work_gukk34cj2ba2hfeeqnbcodfs6m 94 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 94 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 94 9 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 94 10 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 94 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 94 12 blood blood NN work_gukk34cj2ba2hfeeqnbcodfs6m 94 13 donors donor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 94 14 carrying carry VBG work_gukk34cj2ba2hfeeqnbcodfs6m 94 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 94 16 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 94 17 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 94 18 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 94 19 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 94 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 94 21 early early JJ work_gukk34cj2ba2hfeeqnbcodfs6m 94 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 94 23 late late JJ work_gukk34cj2ba2hfeeqnbcodfs6m 94 24 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 94 25 regions region NNS work_gukk34cj2ba2hfeeqnbcodfs6m 94 26 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 94 27 shown show VBN work_gukk34cj2ba2hfeeqnbcodfs6m 94 28 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 94 29 Figure figure NN work_gukk34cj2ba2hfeeqnbcodfs6m 94 30 2C. 2c. CD work_gukk34cj2ba2hfeeqnbcodfs6m 95 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 95 2 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 3 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 95 4 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 95 5 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 95 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 95 7 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 95 8 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 95 9 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 95 10 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 95 11 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 12 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 95 13 worldwide worldwide RB work_gukk34cj2ba2hfeeqnbcodfs6m 95 14 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 95 15 studied study VBD work_gukk34cj2ba2hfeeqnbcodfs6m 95 16 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 95 17 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 95 18 44 44 CD work_gukk34cj2ba2hfeeqnbcodfs6m 95 19 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 95 20 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 95 21 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 95 22 representing represent VBG work_gukk34cj2ba2hfeeqnbcodfs6m 95 23 nationalities nationality NNS work_gukk34cj2ba2hfeeqnbcodfs6m 95 24 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 95 25 Europe Europe NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 26 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 95 27 North North NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 28 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 95 29 South South NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 30 America America NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 31 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 95 32 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 95 33 Near Near NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 34 East East NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 35 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 95 36 Australia Australia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 37 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 95 38 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 95 39 China China NNP work_gukk34cj2ba2hfeeqnbcodfs6m 95 40 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 95 41 Table table NN work_gukk34cj2ba2hfeeqnbcodfs6m 95 42 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 95 43 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 95 44 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 96 1 Patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 96 2 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 3 13 13 CD work_gukk34cj2ba2hfeeqnbcodfs6m 96 4 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 96 5 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 96 6 homozygous homozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 96 7 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 96 9 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 96 10 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 96 11 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 12 nucleotide nucleotide NNP work_gukk34cj2ba2hfeeqnbcodfs6m 96 13 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 96 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 96 15 whereas whereas IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 16 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 96 17 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 18 15 15 CD work_gukk34cj2ba2hfeeqnbcodfs6m 96 19 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 96 20 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 96 21 heterozygous heterozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 96 22 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 23 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 96 24 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 96 25 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 96 26 represented represent VBD work_gukk34cj2ba2hfeeqnbcodfs6m 96 27 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 96 28 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 29 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 96 30 numerous numerous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 96 31 rare rare JJ work_gukk34cj2ba2hfeeqnbcodfs6m 96 32 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 96 33 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 96 34 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 96 35 pairing pairing NN work_gukk34cj2ba2hfeeqnbcodfs6m 96 36 allele allele NN work_gukk34cj2ba2hfeeqnbcodfs6m 96 37 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 96 38 Table table NN work_gukk34cj2ba2hfeeqnbcodfs6m 96 39 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 96 40 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 96 41 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 97 1 Patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 97 2 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 97 3 16 16 CD work_gukk34cj2ba2hfeeqnbcodfs6m 97 4 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 97 5 had have VBD work_gukk34cj2ba2hfeeqnbcodfs6m 97 6 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 97 7 rare rare JJ work_gukk34cj2ba2hfeeqnbcodfs6m 97 8 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 97 9 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 98 1 Patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 98 2 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 98 3 five five CD work_gukk34cj2ba2hfeeqnbcodfs6m 98 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 98 5 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 98 6 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 98 7 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 98 8 homozygous homozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 98 9 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 98 10 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 98 11 private private JJ work_gukk34cj2ba2hfeeqnbcodfs6m 98 12 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 98 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 98 14 suggesting suggest VBG work_gukk34cj2ba2hfeeqnbcodfs6m 98 15 parental parental JJ work_gukk34cj2ba2hfeeqnbcodfs6m 98 16 consanguinity consanguinity NN work_gukk34cj2ba2hfeeqnbcodfs6m 98 17 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 98 18 Table table NN work_gukk34cj2ba2hfeeqnbcodfs6m 98 19 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 98 20 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 98 21 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 99 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 99 2 addition addition NN work_gukk34cj2ba2hfeeqnbcodfs6m 99 3 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 99 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 99 5 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 99 6 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 99 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 99 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 99 9 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 99 10 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 99 11 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 99 12 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 99 13 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 99 14 211 211 CD work_gukk34cj2ba2hfeeqnbcodfs6m 99 15 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 99 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 99 17 only only JJ work_gukk34cj2ba2hfeeqnbcodfs6m 99 18 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 99 19 found find VBD work_gukk34cj2ba2hfeeqnbcodfs6m 99 20 both both CC work_gukk34cj2ba2hfeeqnbcodfs6m 99 21 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 99 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 99 23 Finnish Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 99 24 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 99 25 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 99 26 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 99 27 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 99 28 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 99 29 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 99 30 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 99 31 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 99 32 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 99 33 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 99 34 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 99 35 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 99 36 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 99 37 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 100 1 Like like IN work_gukk34cj2ba2hfeeqnbcodfs6m 100 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 100 3 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 100 4 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 100 5 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 100 6 most most JJS work_gukk34cj2ba2hfeeqnbcodfs6m 100 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 100 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 100 9 rare rare JJ work_gukk34cj2ba2hfeeqnbcodfs6m 100 10 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 100 11 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 100 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 100 13 foreign foreign JJ work_gukk34cj2ba2hfeeqnbcodfs6m 100 14 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 100 15 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 100 16 base base JJ work_gukk34cj2ba2hfeeqnbcodfs6m 100 17 substitutions substitution NNS work_gukk34cj2ba2hfeeqnbcodfs6m 100 18 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 100 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 100 20 transcribed transcribed NNP work_gukk34cj2ba2hfeeqnbcodfs6m 100 21 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 100 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 101 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 101 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 101 3 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 101 4 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 101 5 end end NN work_gukk34cj2ba2hfeeqnbcodfs6m 101 6 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 101 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 101 8 coding code VBG work_gukk34cj2ba2hfeeqnbcodfs6m 101 9 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 101 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 101 11 duplications duplication NNS work_gukk34cj2ba2hfeeqnbcodfs6m 101 12 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 101 13 insertion insertion NN work_gukk34cj2ba2hfeeqnbcodfs6m 101 14 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 101 15 8 8 CD work_gukk34cj2ba2hfeeqnbcodfs6m 101 16 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 101 17 14 14 CD work_gukk34cj2ba2hfeeqnbcodfs6m 101 18 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 101 19 represent represent VBP work_gukk34cj2ba2hfeeqnbcodfs6m 101 20 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 101 21 new new JJ work_gukk34cj2ba2hfeeqnbcodfs6m 101 22 type type NN work_gukk34cj2ba2hfeeqnbcodfs6m 101 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 101 24 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 101 25 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 101 26 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 101 27 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 101 28 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 101 29 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 102 1 All all DT work_gukk34cj2ba2hfeeqnbcodfs6m 102 2 sites site NNS work_gukk34cj2ba2hfeeqnbcodfs6m 102 3 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 102 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 102 5 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 102 6 types type NNS work_gukk34cj2ba2hfeeqnbcodfs6m 102 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 102 8 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 102 9 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 102 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 102 11 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 102 12 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 102 13 evolutionally evolutionally RB work_gukk34cj2ba2hfeeqnbcodfs6m 102 14 conserved24,25 conserved24,25 NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 102 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 102 16 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 102 17 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 102 18 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 102 19 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 102 20 120 120 CD work_gukk34cj2ba2hfeeqnbcodfs6m 102 21 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 102 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 102 23 160 160 CD work_gukk34cj2ba2hfeeqnbcodfs6m 102 24 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 102 25 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 102 26 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 102 27 controls control NNS work_gukk34cj2ba2hfeeqnbcodfs6m 102 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 103 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 103 2 did do VBD work_gukk34cj2ba2hfeeqnbcodfs6m 103 3 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 103 4 find find VB work_gukk34cj2ba2hfeeqnbcodfs6m 103 5 any any DT work_gukk34cj2ba2hfeeqnbcodfs6m 103 6 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 103 7 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 103 8 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 103 9 nine nine CD work_gukk34cj2ba2hfeeqnbcodfs6m 103 10 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 103 11 who who WP work_gukk34cj2ba2hfeeqnbcodfs6m 103 12 probably probably RB work_gukk34cj2ba2hfeeqnbcodfs6m 103 13 do do VBP work_gukk34cj2ba2hfeeqnbcodfs6m 103 14 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 103 15 have have VB work_gukk34cj2ba2hfeeqnbcodfs6m 103 16 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 103 17 but but CC work_gukk34cj2ba2hfeeqnbcodfs6m 103 18 another another DT work_gukk34cj2ba2hfeeqnbcodfs6m 103 19 type type NN work_gukk34cj2ba2hfeeqnbcodfs6m 103 20 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 103 21 chondrodysplasia chondrodysplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 103 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 104 1 Since since IN work_gukk34cj2ba2hfeeqnbcodfs6m 104 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 104 3 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 104 4 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 104 5 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 104 6 nucleotide nucleotide NNP work_gukk34cj2ba2hfeeqnbcodfs6m 104 7 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 104 8 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 104 9 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 104 10 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 104 11 several several JJ work_gukk34cj2ba2hfeeqnbcodfs6m 104 12 countries country NNS work_gukk34cj2ba2hfeeqnbcodfs6m 104 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 104 14 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 104 15 asked ask VBD work_gukk34cj2ba2hfeeqnbcodfs6m 104 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 104 17 question question NN work_gukk34cj2ba2hfeeqnbcodfs6m 104 18 whether whether IN work_gukk34cj2ba2hfeeqnbcodfs6m 104 19 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 104 20 muta- muta- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 104 21 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 104 22 had have VBD work_gukk34cj2ba2hfeeqnbcodfs6m 104 23 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 104 24 single single JJ work_gukk34cj2ba2hfeeqnbcodfs6m 104 25 origin origin NN work_gukk34cj2ba2hfeeqnbcodfs6m 104 26 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 104 27 if if IN work_gukk34cj2ba2hfeeqnbcodfs6m 104 28 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 104 29 nucleotide nucleotide NN work_gukk34cj2ba2hfeeqnbcodfs6m 104 30 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 104 31 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 104 32 hot hot JJ work_gukk34cj2ba2hfeeqnbcodfs6m 104 33 spot spot NN work_gukk34cj2ba2hfeeqnbcodfs6m 104 34 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 104 35 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 104 36 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 105 1 Eight eight CD work_gukk34cj2ba2hfeeqnbcodfs6m 105 2 homozygous homozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 105 3 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 105 4 nine nine CD work_gukk34cj2ba2hfeeqnbcodfs6m 105 5 heterozygous heterozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 105 6 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 105 7 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 105 8 their -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 105 9 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 105 10 members member NNS work_gukk34cj2ba2hfeeqnbcodfs6m 105 11 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 105 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 105 13 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 105 14 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 105 15 CEPH CEPH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 105 16 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 105 17 Centre Centre NNP work_gukk34cj2ba2hfeeqnbcodfs6m 105 18 d’Etude d’Etude NNP work_gukk34cj2ba2hfeeqnbcodfs6m 105 19 Polymorphisme Polymorphisme NNP work_gukk34cj2ba2hfeeqnbcodfs6m 105 20 Humain Humain NNP work_gukk34cj2ba2hfeeqnbcodfs6m 105 21 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 105 22 controls control NNS work_gukk34cj2ba2hfeeqnbcodfs6m 105 23 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 105 24 genotyped genotype VBN work_gukk34cj2ba2hfeeqnbcodfs6m 105 25 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 105 26 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 105 27 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 105 28 reconstructed reconstruct VBN work_gukk34cj2ba2hfeeqnbcodfs6m 105 29 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 106 1 Chromo- Chromo- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 106 2 somes some VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 106 3 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 106 4 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 106 5 nationalities nationality NNS work_gukk34cj2ba2hfeeqnbcodfs6m 106 6 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 106 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 106 8 Old Old NNP work_gukk34cj2ba2hfeeqnbcodfs6m 106 9 Order Order NNP work_gukk34cj2ba2hfeeqnbcodfs6m 106 10 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 106 11 carrying carry VBG work_gukk34cj2ba2hfeeqnbcodfs6m 106 12 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 106 13 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 106 14 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 106 15 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 106 16 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 106 17 shared share VBD work_gukk34cj2ba2hfeeqnbcodfs6m 106 18 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 106 19 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 106 20 Figure figure NN work_gukk34cj2ba2hfeeqnbcodfs6m 106 21 2 2 CD work_gukk34cj2ba2hfeeqnbcodfs6m 106 22 Geographical geographical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 106 23 distribution distribution NN work_gukk34cj2ba2hfeeqnbcodfs6m 106 24 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 106 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 106 26 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 106 27 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 106 28 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 106 29 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 106 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 107 1 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 107 2 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 107 3 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 107 4 Birthplaces birthplace NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 5 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 107 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 107 7 great great JJ work_gukk34cj2ba2hfeeqnbcodfs6m 107 8 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 107 9 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 10 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 107 11 107 107 CD work_gukk34cj2ba2hfeeqnbcodfs6m 107 12 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 107 13 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 14 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 107 15 83 83 CD work_gukk34cj2ba2hfeeqnbcodfs6m 107 16 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 107 17 families).2 families).2 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 107 18 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 107 19 B b NN work_gukk34cj2ba2hfeeqnbcodfs6m 107 20 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 107 21 Birthplaces birthplace NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 22 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 107 23 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 24 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 107 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 107 26 carriers carrier NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 27 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 107 28 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 107 29 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 107 30 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 31 ’ ’ POS work_gukk34cj2ba2hfeeqnbcodfs6m 107 32 parents parent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 33 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 107 34 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 107 35 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 107 36 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 107 37 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 107 38 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 107 39 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 107 40 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 108 1 * * NFP work_gukk34cj2ba2hfeeqnbcodfs6m 108 2 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 108 3 G262 G262 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 108 4 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 108 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 108 6 & & CC work_gukk34cj2ba2hfeeqnbcodfs6m 108 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 108 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 108 9 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 108 10 duplication duplication NN work_gukk34cj2ba2hfeeqnbcodfs6m 108 11 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 108 12 ~ ~ NFP work_gukk34cj2ba2hfeeqnbcodfs6m 108 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 108 14 G154 G154 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 108 15 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 108 16 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 108 17 ! ! . work_gukk34cj2ba2hfeeqnbcodfs6m 108 18 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 108 19 C211 C211 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 108 20 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 108 21 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 108 22 C C NNP work_gukk34cj2ba2hfeeqnbcodfs6m 108 23 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 108 24 Birthplaces Birthplaces NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 108 25 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 108 26 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 108 27 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 108 28 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 108 29 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 108 30 blood blood NN work_gukk34cj2ba2hfeeqnbcodfs6m 108 31 donors donor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 108 32 carrying carry VBG work_gukk34cj2ba2hfeeqnbcodfs6m 108 33 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 108 34 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 108 35 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 108 36 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 108 37 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 108 38 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 109 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 109 2 each each DT work_gukk34cj2ba2hfeeqnbcodfs6m 109 3 map map NN work_gukk34cj2ba2hfeeqnbcodfs6m 109 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 109 5 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 109 6 symbol symbol NN work_gukk34cj2ba2hfeeqnbcodfs6m 109 7 depicts depict VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 109 8 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 109 9 great great JJ work_gukk34cj2ba2hfeeqnbcodfs6m 109 10 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 109 11 grandparent grandparent NN work_gukk34cj2ba2hfeeqnbcodfs6m 109 12 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 109 13 grandparent grandparent JJ work_gukk34cj2ba2hfeeqnbcodfs6m 109 14 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 110 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 110 2 line line NN work_gukk34cj2ba2hfeeqnbcodfs6m 110 3 denotes denote VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 110 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 110 5 approximate approximate JJ work_gukk34cj2ba2hfeeqnbcodfs6m 110 6 border border NN work_gukk34cj2ba2hfeeqnbcodfs6m 110 7 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 110 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 110 9 old old JJ work_gukk34cj2ba2hfeeqnbcodfs6m 110 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 110 11 new new JJ work_gukk34cj2ba2hfeeqnbcodfs6m 110 12 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 110 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 110 14 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 110 15 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 111 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 111 2 area area NN work_gukk34cj2ba2hfeeqnbcodfs6m 111 3 depicted depict VBN work_gukk34cj2ba2hfeeqnbcodfs6m 111 4 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 111 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 111 6 dotted dotted JJ work_gukk34cj2ba2hfeeqnbcodfs6m 111 7 line line NN work_gukk34cj2ba2hfeeqnbcodfs6m 111 8 belonged belong VBD work_gukk34cj2ba2hfeeqnbcodfs6m 111 9 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 111 10 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 111 11 before before IN work_gukk34cj2ba2hfeeqnbcodfs6m 111 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 111 13 Second Second NNP work_gukk34cj2ba2hfeeqnbcodfs6m 111 14 World World NNP work_gukk34cj2ba2hfeeqnbcodfs6m 111 15 War War NNP work_gukk34cj2ba2hfeeqnbcodfs6m 111 16 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 112 1 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 112 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 112 4 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 112 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 112 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 112 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 8 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 9 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 12 444 444 CD work_gukk34cj2ba2hfeeqnbcodfs6m 112 13 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 14 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 112 16 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 17 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 112 18 alleles allele VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 112 19 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 112 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 112 21 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 112 22 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 112 23 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 112 24 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 112 25 Figure figure NN work_gukk34cj2ba2hfeeqnbcodfs6m 112 26 1B 1b NN work_gukk34cj2ba2hfeeqnbcodfs6m 112 27 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 112 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 113 1 Twenty twenty CD work_gukk34cj2ba2hfeeqnbcodfs6m 113 2 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 113 3 three three CD work_gukk34cj2ba2hfeeqnbcodfs6m 113 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 113 6 27 27 CD work_gukk34cj2ba2hfeeqnbcodfs6m 113 7 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 113 8 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 113 9 similar similar JJ work_gukk34cj2ba2hfeeqnbcodfs6m 113 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 113 11 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 12 least least JJS work_gukk34cj2ba2hfeeqnbcodfs6m 113 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 14 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 113 15 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 113 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 17 60 60 CD work_gukk34cj2ba2hfeeqnbcodfs6m 113 18 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 113 19 around around IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 113 21 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 113 22 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 113 23 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 113 24 clearly clearly RB work_gukk34cj2ba2hfeeqnbcodfs6m 113 25 point- point- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 113 26 ing e VBG work_gukk34cj2ba2hfeeqnbcodfs6m 113 27 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 28 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 113 29 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 113 30 origin origin NN work_gukk34cj2ba2hfeeqnbcodfs6m 113 31 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 32 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 113 33 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 113 34 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 113 35 rather rather RB work_gukk34cj2ba2hfeeqnbcodfs6m 113 36 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 37 due due IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 38 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 113 39 frequent frequent JJ work_gukk34cj2ba2hfeeqnbcodfs6m 113 40 occurrence occurrence NN work_gukk34cj2ba2hfeeqnbcodfs6m 113 41 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 114 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 114 2 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 114 3 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 114 4 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 5 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 114 6 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 114 7 According accord VBG work_gukk34cj2ba2hfeeqnbcodfs6m 114 8 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 114 9 our -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 114 10 maximum maximum JJ work_gukk34cj2ba2hfeeqnbcodfs6m 114 11 likelihood likelihood NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 12 estimates estimate VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 114 13 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 114 14 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 114 15 DMLE DMLE NNP work_gukk34cj2ba2hfeeqnbcodfs6m 114 16 program21 program21 NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 114 18 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 114 19 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 114 20 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 21 arrived arrive VBD work_gukk34cj2ba2hfeeqnbcodfs6m 114 22 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 114 23 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 114 24 some some DT work_gukk34cj2ba2hfeeqnbcodfs6m 114 25 130 130 CD work_gukk34cj2ba2hfeeqnbcodfs6m 114 26 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 114 27 160 160 CD work_gukk34cj2ba2hfeeqnbcodfs6m 114 28 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 114 29 ago ago RB work_gukk34cj2ba2hfeeqnbcodfs6m 114 30 corresponding correspond VBG work_gukk34cj2ba2hfeeqnbcodfs6m 114 31 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 114 32 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 114 33 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 34 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 114 35 given give VBN work_gukk34cj2ba2hfeeqnbcodfs6m 114 36 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 114 37 generation generation NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 38 time time NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 39 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 114 40 30 30 CD work_gukk34cj2ba2hfeeqnbcodfs6m 114 41 years)26 years)26 NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 42 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 114 43 approxi- approxi- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 114 44 mately mately RB work_gukk34cj2ba2hfeeqnbcodfs6m 114 45 3900 3900 CD work_gukk34cj2ba2hfeeqnbcodfs6m 114 46 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 114 47 4800 4800 CD work_gukk34cj2ba2hfeeqnbcodfs6m 114 48 years year NNS work_gukk34cj2ba2hfeeqnbcodfs6m 114 49 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 114 50 Figure figure NN work_gukk34cj2ba2hfeeqnbcodfs6m 114 51 3 3 CD work_gukk34cj2ba2hfeeqnbcodfs6m 114 52 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 114 53 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 115 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 115 2 estimates estimate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 115 3 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 115 4 computed compute VBN work_gukk34cj2ba2hfeeqnbcodfs6m 115 5 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 115 6 five five CD work_gukk34cj2ba2hfeeqnbcodfs6m 115 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 115 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 115 9 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 115 10 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 115 11 TESK1 TESK1 `` work_gukk34cj2ba2hfeeqnbcodfs6m 115 12 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 115 13 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 115 14 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 115 15 SSCP SSCP NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 115 16 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 115 17 delG delg NN work_gukk34cj2ba2hfeeqnbcodfs6m 115 18 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 115 19 D4S D4S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 115 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 115 21 AC1 AC1 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 115 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 115 23 XL1S XL1S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 115 24 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 115 25 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 115 26 averaging average VBG work_gukk34cj2ba2hfeeqnbcodfs6m 115 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 115 28 likelihood likelihood NN work_gukk34cj2ba2hfeeqnbcodfs6m 115 29 points point NNS work_gukk34cj2ba2hfeeqnbcodfs6m 115 30 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 115 31 each each DT work_gukk34cj2ba2hfeeqnbcodfs6m 115 32 consisting consist VBG work_gukk34cj2ba2hfeeqnbcodfs6m 115 33 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 115 34 either either CC work_gukk34cj2ba2hfeeqnbcodfs6m 115 35 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 115 36 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 115 37 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 115 38 million million CD work_gukk34cj2ba2hfeeqnbcodfs6m 115 39 Monte Monte NNP work_gukk34cj2ba2hfeeqnbcodfs6m 115 40 Carlo Carlo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 115 41 replicates replicate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 115 42 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 115 43 Figure figure NN work_gukk34cj2ba2hfeeqnbcodfs6m 115 44 3 3 CD work_gukk34cj2ba2hfeeqnbcodfs6m 115 45 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 115 46 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 116 1 Using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 116 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 116 3 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 116 4 five five CD work_gukk34cj2ba2hfeeqnbcodfs6m 116 5 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 116 6 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 116 7 esti- esti- NN work_gukk34cj2ba2hfeeqnbcodfs6m 116 8 mates mate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 116 9 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 116 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 116 11 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 116 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 116 13 physical physical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 116 14 correspondence correspondence NN work_gukk34cj2ba2hfeeqnbcodfs6m 116 15 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 116 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 116 17 method method NN work_gukk34cj2ba2hfeeqnbcodfs6m 116 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 116 19 Risch Risch NNP work_gukk34cj2ba2hfeeqnbcodfs6m 116 20 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 116 21 al22 al22 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 116 22 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 116 23 resulted result VBD work_gukk34cj2ba2hfeeqnbcodfs6m 116 24 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 116 25 high high JJ work_gukk34cj2ba2hfeeqnbcodfs6m 116 26 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 116 27 estimates estimate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 116 28 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 116 29 although although IN work_gukk34cj2ba2hfeeqnbcodfs6m 116 30 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 116 31 much much RB work_gukk34cj2ba2hfeeqnbcodfs6m 116 32 wider wide JJR work_gukk34cj2ba2hfeeqnbcodfs6m 116 33 limits limit NNS work_gukk34cj2ba2hfeeqnbcodfs6m 116 34 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 116 35 150 150 CD work_gukk34cj2ba2hfeeqnbcodfs6m 116 36 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 116 37 314 314 CD work_gukk34cj2ba2hfeeqnbcodfs6m 116 38 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 116 39 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 117 1 These these DT work_gukk34cj2ba2hfeeqnbcodfs6m 117 2 high high JJ work_gukk34cj2ba2hfeeqnbcodfs6m 117 3 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 117 4 estimates estimate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 117 5 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 117 6 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 117 7 keeping keep VBG work_gukk34cj2ba2hfeeqnbcodfs6m 117 8 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 117 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 117 10 distribu- distribu- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 117 11 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 117 12 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 117 13 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 117 14 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 117 15 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 117 16 which which WDT work_gukk34cj2ba2hfeeqnbcodfs6m 117 17 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 117 18 suggests suggest VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 117 19 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 117 20 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 117 21 introduction introduction NN work_gukk34cj2ba2hfeeqnbcodfs6m 117 22 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 117 23 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 117 24 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 117 25 into into IN work_gukk34cj2ba2hfeeqnbcodfs6m 117 26 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 117 27 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 117 28 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 117 29 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 118 1 Discussion discussion NN work_gukk34cj2ba2hfeeqnbcodfs6m 118 2 Recently recently RB work_gukk34cj2ba2hfeeqnbcodfs6m 118 3 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 118 4 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 118 5 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 118 6 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 118 7 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 118 8 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 118 9 types type NNS work_gukk34cj2ba2hfeeqnbcodfs6m 118 10 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 118 11 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 118 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 118 13 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 118 14 can can MD work_gukk34cj2ba2hfeeqnbcodfs6m 118 15 lead lead VB work_gukk34cj2ba2hfeeqnbcodfs6m 118 16 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 118 17 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 118 18 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 118 19 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 118 20 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 118 21 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 119 1 Duplications duplication NNS work_gukk34cj2ba2hfeeqnbcodfs6m 119 2 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 119 3 insertions insertion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 119 4 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 6 TATA TATA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 119 7 box box NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 8 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 119 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 10 transcription transcription NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 11 initiation initiation NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 12 site site NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 13 silence silence NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 14 transcription transcription NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 15 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 16 that that DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 17 allele allele RB work_gukk34cj2ba2hfeeqnbcodfs6m 119 18 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 119 19 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 119 20 changes change NNS work_gukk34cj2ba2hfeeqnbcodfs6m 119 21 involving involve VBG work_gukk34cj2ba2hfeeqnbcodfs6m 119 22 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 23 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 119 24 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 119 25 highly highly RB work_gukk34cj2ba2hfeeqnbcodfs6m 119 26 conserved conserve VBN work_gukk34cj2ba2hfeeqnbcodfs6m 119 27 nucleo- nucleo- NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 28 tides tide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 119 29 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 30 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 31 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 32 lead lead VBP work_gukk34cj2ba2hfeeqnbcodfs6m 119 33 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 34 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 35 homozygous homozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 119 36 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 119 37 compound compound JJ work_gukk34cj2ba2hfeeqnbcodfs6m 119 38 heterozygous heterozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 119 39 mutant mutant NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 40 transcript.12 transcript.12 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 119 41 Altogether Altogether NNP work_gukk34cj2ba2hfeeqnbcodfs6m 119 42 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 119 43 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 44 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 45 set set NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 46 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 47 91 91 CD work_gukk34cj2ba2hfeeqnbcodfs6m 119 48 Finnish Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 119 49 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 119 50 44 44 CD work_gukk34cj2ba2hfeeqnbcodfs6m 119 51 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 119 52 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 119 53 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 54 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 119 55 countries country NNS work_gukk34cj2ba2hfeeqnbcodfs6m 119 56 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 119 57 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 119 58 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 119 59 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 119 60 36 36 CD work_gukk34cj2ba2hfeeqnbcodfs6m 119 61 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 119 62 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 119 63 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 64 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 65 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 119 66 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 67 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 119 68 28 28 CD work_gukk34cj2ba2hfeeqnbcodfs6m 119 69 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 70 them -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 119 71 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 119 72 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 119 73 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 74 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 75 first first JJ work_gukk34cj2ba2hfeeqnbcodfs6m 119 76 time time NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 77 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 119 78 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 119 79 paper paper NN work_gukk34cj2ba2hfeeqnbcodfs6m 119 80 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 120 1 These these DT work_gukk34cj2ba2hfeeqnbcodfs6m 120 2 can can MD work_gukk34cj2ba2hfeeqnbcodfs6m 120 3 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 120 4 classified classify VBN work_gukk34cj2ba2hfeeqnbcodfs6m 120 5 into into IN work_gukk34cj2ba2hfeeqnbcodfs6m 120 6 three three CD work_gukk34cj2ba2hfeeqnbcodfs6m 120 7 groups group NNS work_gukk34cj2ba2hfeeqnbcodfs6m 120 8 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 121 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 121 2 first first JJ work_gukk34cj2ba2hfeeqnbcodfs6m 121 3 group group NN work_gukk34cj2ba2hfeeqnbcodfs6m 121 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 121 5 muta- muta- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 121 6 tions tion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 121 7 consists consist VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 121 8 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 121 9 eight eight CD work_gukk34cj2ba2hfeeqnbcodfs6m 121 10 insertions insertion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 121 11 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 121 12 duplications duplication NNS work_gukk34cj2ba2hfeeqnbcodfs6m 121 13 that that WDT work_gukk34cj2ba2hfeeqnbcodfs6m 121 14 affect affect VBP work_gukk34cj2ba2hfeeqnbcodfs6m 121 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 121 16 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 121 17 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 121 18 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 122 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 122 2 second second JJ work_gukk34cj2ba2hfeeqnbcodfs6m 122 3 group group NN work_gukk34cj2ba2hfeeqnbcodfs6m 122 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 122 5 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 122 6 consists consist VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 122 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 122 8 24 24 CD work_gukk34cj2ba2hfeeqnbcodfs6m 122 9 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 122 10 substitutions substitution NNS work_gukk34cj2ba2hfeeqnbcodfs6m 122 11 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 122 12 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 122 13 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 122 14 changes change NNS work_gukk34cj2ba2hfeeqnbcodfs6m 122 15 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 122 16 conserved conserved JJ work_gukk34cj2ba2hfeeqnbcodfs6m 122 17 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 122 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 122 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 122 20 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 122 21 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 123 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 123 2 addition addition NN work_gukk34cj2ba2hfeeqnbcodfs6m 123 3 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 123 4 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 123 5 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 123 6 characterised characterise VBN work_gukk34cj2ba2hfeeqnbcodfs6m 123 7 herein herein NNP work_gukk34cj2ba2hfeeqnbcodfs6m 123 8 three three CD work_gukk34cj2ba2hfeeqnbcodfs6m 123 9 insertions insertion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 123 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 123 11 duplications duplication NNS work_gukk34cj2ba2hfeeqnbcodfs6m 123 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 123 13 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 123 14 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 123 15 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 123 16 end end NN work_gukk34cj2ba2hfeeqnbcodfs6m 123 17 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 123 18 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 123 19 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 123 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 123 21 which which WDT work_gukk34cj2ba2hfeeqnbcodfs6m 123 22 form form VBP work_gukk34cj2ba2hfeeqnbcodfs6m 123 23 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 123 24 third third JJ work_gukk34cj2ba2hfeeqnbcodfs6m 123 25 group group NN work_gukk34cj2ba2hfeeqnbcodfs6m 123 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 123 27 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 123 28 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 123 29 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 123 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 124 1 These these DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 124 3 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 124 4 gathered gather VBN work_gukk34cj2ba2hfeeqnbcodfs6m 124 5 around around IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 7 nucleolar nucleolar JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 8 localisation localisation NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 9 signal signal NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 10 region27 region27 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 11 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 124 12 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 13 regions region NNS work_gukk34cj2ba2hfeeqnbcodfs6m 124 14 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 124 15 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 124 16 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 124 17 important important JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 18 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 19 binding bind VBG work_gukk34cj2ba2hfeeqnbcodfs6m 124 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 21 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 22 proteins protein NNS work_gukk34cj2ba2hfeeqnbcodfs6m 124 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 25 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 26 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 27 complex.13 complex.13 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 28 Only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 124 29 heterozygosity heterozygosity NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 30 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 31 inser- inser- NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 32 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 33 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 124 34 further further JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 35 duplication duplication NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 36 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 124 37 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 38 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 39 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 40 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 41 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 124 42 ‘ ' `` work_gukk34cj2ba2hfeeqnbcodfs6m 124 43 null null JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 44 ’ ' '' work_gukk34cj2ba2hfeeqnbcodfs6m 124 45 alleles allele NNS work_gukk34cj2ba2hfeeqnbcodfs6m 124 46 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 47 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 48 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 124 49 detected detect VBN work_gukk34cj2ba2hfeeqnbcodfs6m 124 50 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 124 51 further further RB work_gukk34cj2ba2hfeeqnbcodfs6m 124 52 suggesting suggest VBG work_gukk34cj2ba2hfeeqnbcodfs6m 124 53 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 54 expression expression NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 55 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 56 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 57 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 58 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 59 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 60 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 124 61 indeed indeed RB work_gukk34cj2ba2hfeeqnbcodfs6m 124 62 essential essential JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 63 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 64 life.12,28 life.12,28 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 65 Mutations Mutations NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 124 66 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 67 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 68 seem seem VBP work_gukk34cj2ba2hfeeqnbcodfs6m 124 69 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 124 70 avoid avoid VB work_gukk34cj2ba2hfeeqnbcodfs6m 124 71 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 124 72 23 23 CD work_gukk34cj2ba2hfeeqnbcodfs6m 124 73 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 124 74 62 62 CD work_gukk34cj2ba2hfeeqnbcodfs6m 124 75 which which WDT work_gukk34cj2ba2hfeeqnbcodfs6m 124 76 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 124 77 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 124 78 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 124 79 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 124 80 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 124 81 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 82 nucleolar nucleolar JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 83 localisation localisation NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 84 signal signal NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 85 region.27 region.27 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 124 86 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 124 87 found find VBD work_gukk34cj2ba2hfeeqnbcodfs6m 124 88 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 89 compound compound NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 90 heterozygous heterozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 91 muta- muta- NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 92 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 93 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 94 nucleotide nucleotide IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 95 57 57 CD work_gukk34cj2ba2hfeeqnbcodfs6m 124 96 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 97 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 124 98 patient patient NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 99 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 124 100 but but CC work_gukk34cj2ba2hfeeqnbcodfs6m 124 101 due due IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 102 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 103 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 104 sequence sequence NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 105 content content NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 106 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 107 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 108 duplication duplication NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 109 it -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 124 110 does do VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 124 111 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 124 112 change change VB work_gukk34cj2ba2hfeeqnbcodfs6m 124 113 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 114 sequence sequence NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 115 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 124 116 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 124 117 nucleolar nucleolar JJ work_gukk34cj2ba2hfeeqnbcodfs6m 124 118 localisation localisation NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 119 signal signal NN work_gukk34cj2ba2hfeeqnbcodfs6m 124 120 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 125 1 On on IN work_gukk34cj2ba2hfeeqnbcodfs6m 125 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 125 3 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 125 4 hand hand NN work_gukk34cj2ba2hfeeqnbcodfs6m 125 5 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 125 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 125 7 mitochondrial mitochondrial NN work_gukk34cj2ba2hfeeqnbcodfs6m 125 8 localisation localisation NN work_gukk34cj2ba2hfeeqnbcodfs6m 125 9 signal signal NN work_gukk34cj2ba2hfeeqnbcodfs6m 125 10 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 125 11 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 125 12 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 125 13 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 125 14 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 125 15 reside reside VB work_gukk34cj2ba2hfeeqnbcodfs6m 125 16 between between IN work_gukk34cj2ba2hfeeqnbcodfs6m 125 17 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 125 18 118 118 CD work_gukk34cj2ba2hfeeqnbcodfs6m 125 19 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 125 20 175 175 CD work_gukk34cj2ba2hfeeqnbcodfs6m 125 21 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 125 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 125 23 mouse29 mouse29 NN work_gukk34cj2ba2hfeeqnbcodfs6m 125 24 which which WDT work_gukk34cj2ba2hfeeqnbcodfs6m 125 25 corresponds correspond VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 125 26 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 125 27 nucleotides nucleotide NNS work_gukk34cj2ba2hfeeqnbcodfs6m 125 28 118 118 CD work_gukk34cj2ba2hfeeqnbcodfs6m 125 29 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 125 30 167 167 CD work_gukk34cj2ba2hfeeqnbcodfs6m 125 31 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 125 32 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 125 33 human human JJ work_gukk34cj2ba2hfeeqnbcodfs6m 125 34 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 125 35 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 126 1 This this DT work_gukk34cj2ba2hfeeqnbcodfs6m 126 2 stretch stretch NN work_gukk34cj2ba2hfeeqnbcodfs6m 126 3 harbors harbor VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 126 4 four four CD work_gukk34cj2ba2hfeeqnbcodfs6m 126 5 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 126 6 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 126 7 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 126 8 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 126 9 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 126 10 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 126 11 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 126 12 even even RB work_gukk34cj2ba2hfeeqnbcodfs6m 126 13 homozy- homozy- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 126 14 gous gous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 126 15 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 126 16 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 126 17 kind kind NN work_gukk34cj2ba2hfeeqnbcodfs6m 126 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 126 19 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 126 20 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 127 1 Functional functional JJ work_gukk34cj2ba2hfeeqnbcodfs6m 127 2 studies study NNS work_gukk34cj2ba2hfeeqnbcodfs6m 127 3 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 127 4 needed need VBN work_gukk34cj2ba2hfeeqnbcodfs6m 127 5 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 127 6 further far RBR work_gukk34cj2ba2hfeeqnbcodfs6m 127 7 clarify clarify VB work_gukk34cj2ba2hfeeqnbcodfs6m 127 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 127 9 viability viability NN work_gukk34cj2ba2hfeeqnbcodfs6m 127 10 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 127 11 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 127 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 127 13 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 127 14 nucleolar nucleolar JJ work_gukk34cj2ba2hfeeqnbcodfs6m 127 15 localisation localisation NNP work_gukk34cj2ba2hfeeqnbcodfs6m 127 16 signal signal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 127 17 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 127 18 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 127 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 127 20 significance significance NN work_gukk34cj2ba2hfeeqnbcodfs6m 127 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 127 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 127 23 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 127 24 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 127 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 127 26 mitochondrial mitochondrial NN work_gukk34cj2ba2hfeeqnbcodfs6m 127 27 localisation localisation NN work_gukk34cj2ba2hfeeqnbcodfs6m 127 28 signal signal NN work_gukk34cj2ba2hfeeqnbcodfs6m 127 29 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 127 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 128 1 Cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 2 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 128 3 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 4 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 5 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 128 6 five five CD work_gukk34cj2ba2hfeeqnbcodfs6m 128 7 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 8 diseases disease NNS work_gukk34cj2ba2hfeeqnbcodfs6m 128 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 11 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 12 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 13 heritage heritage NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 15 namely namely RB work_gukk34cj2ba2hfeeqnbcodfs6m 128 16 aspartylglucosaminuria aspartylglucosaminuria NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 17 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 18 AGU AGU NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 19 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 21 progressive progressive NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 22 myoclonus myoclonus NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 23 epilepsy epilepsy NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 24 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 25 PME PME NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 26 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 27 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 28 infantile infantile JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 29 neuronal neuronal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 30 ceroid ceroid NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 31 lipofuscinosis lipofuscinosis NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 32 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 33 INCL INCL NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 34 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 35 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 36 juvenile juvenile JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 37 neuronal neuronal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 38 ceroid ceroid NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 39 lipofuscinosis lipofuscinosis NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 40 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 41 JNCL JNCL NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 42 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 43 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 44 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 128 45 congenital congenital JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 46 nephrotic nephrotic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 47 syndrome syndrome NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 48 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 49 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 50 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 51 type type NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 52 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 53 CNF CNF NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 54 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 128 55 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 56 show show VBP work_gukk34cj2ba2hfeeqnbcodfs6m 128 57 similar similar JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 58 distribu- distribu- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 59 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 60 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 61 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 62 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 63 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 128 64 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 65 each each DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 66 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 67 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 68 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 69 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 70 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 71 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 128 72 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 128 73 found find VBN work_gukk34cj2ba2hfeeqnbcodfs6m 128 74 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 75 78 78 CD work_gukk34cj2ba2hfeeqnbcodfs6m 128 76 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 128 77 98 98 CD work_gukk34cj2ba2hfeeqnbcodfs6m 128 78 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 79 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 80 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 81 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 82 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 83 chromo- chromo- NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 84 somes.30 somes.30 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 85 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 128 86 34 34 CD work_gukk34cj2ba2hfeeqnbcodfs6m 128 87 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 88 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 89 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 90 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 91 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 92 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 128 93 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 94 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 128 95 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 128 96 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 128 97 been be VBN work_gukk34cj2ba2hfeeqnbcodfs6m 128 98 calculated calculate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 128 99 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 128 100 but but CC work_gukk34cj2ba2hfeeqnbcodfs6m 128 101 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 102 distribution distribution NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 103 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 104 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 105 birth- birth- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 106 places place NNS work_gukk34cj2ba2hfeeqnbcodfs6m 128 107 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 108 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 109 great great JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 110 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 128 111 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 128 112 supports support VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 128 113 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 114 hypothesis hypothesis NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 115 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 116 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 117 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 128 118 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 128 119 present present JJ work_gukk34cj2ba2hfeeqnbcodfs6m 128 120 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 128 121 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 128 122 founding found VBG work_gukk34cj2ba2hfeeqnbcodfs6m 128 123 popula- popula- NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 124 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 128 125 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 129 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 2 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 129 3 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 129 4 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 5 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 7 Finnish Finnish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 129 8 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 129 9 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 129 10 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 129 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 12 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 13 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 14 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 15 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 16 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 17 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 18 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 129 19 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 129 20 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 21 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 129 22 representing represent VBG work_gukk34cj2ba2hfeeqnbcodfs6m 129 23 92 92 CD work_gukk34cj2ba2hfeeqnbcodfs6m 129 24 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 25 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 129 26 211/230 211/230 NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 27 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 129 28 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 29 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 30 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 31 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 129 32 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 129 33 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 34 study).12 study).12 NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 35 Our -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 129 36 computation computation NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 37 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 129 38 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 129 39 Monte Monte NNP work_gukk34cj2ba2hfeeqnbcodfs6m 129 40 Carlo Carlo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 129 41 sampling sampling NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 42 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 129 43 results result NNS work_gukk34cj2ba2hfeeqnbcodfs6m 129 44 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 45 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 46 estimate estimate NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 47 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 48 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 49 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 129 50 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 51 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 129 52 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 129 53 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 54 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 129 55 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 129 56 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 129 57 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 129 58 likely likely RB work_gukk34cj2ba2hfeeqnbcodfs6m 129 59 introduced introduce VBN work_gukk34cj2ba2hfeeqnbcodfs6m 129 60 before before IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 61 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 62 hypothesised hypothesise VBN work_gukk34cj2ba2hfeeqnbcodfs6m 129 63 time time NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 64 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 129 65 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 129 66 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 67 expansion expansion NN work_gukk34cj2ba2hfeeqnbcodfs6m 129 68 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 130 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 130 2 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 130 3 conspicuous conspicuous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 130 4 single single JJ work_gukk34cj2ba2hfeeqnbcodfs6m 130 5 parameter parameter NN work_gukk34cj2ba2hfeeqnbcodfs6m 130 6 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 130 7 these these DT work_gukk34cj2ba2hfeeqnbcodfs6m 130 8 estimates estimate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 130 9 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 130 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 130 11 correspondence correspondence NN work_gukk34cj2ba2hfeeqnbcodfs6m 130 12 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 130 13 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 130 14 physical physical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 130 15 map map NN work_gukk34cj2ba2hfeeqnbcodfs6m 130 16 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 130 17 recombination recombination NN work_gukk34cj2ba2hfeeqnbcodfs6m 130 18 probabilities probability NNS work_gukk34cj2ba2hfeeqnbcodfs6m 130 19 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 130 20 very very RB work_gukk34cj2ba2hfeeqnbcodfs6m 130 21 short short JJ work_gukk34cj2ba2hfeeqnbcodfs6m 130 22 map map NN work_gukk34cj2ba2hfeeqnbcodfs6m 130 23 lengths length NNS work_gukk34cj2ba2hfeeqnbcodfs6m 130 24 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 131 1 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 131 2 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 131 3 able able JJ work_gukk34cj2ba2hfeeqnbcodfs6m 131 4 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 131 5 esti- esti- VB work_gukk34cj2ba2hfeeqnbcodfs6m 131 6 mate mate VB work_gukk34cj2ba2hfeeqnbcodfs6m 131 7 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 131 8 2.1 2.1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 131 9 Mb Mb NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 10 corresponds correspond VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 131 11 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 131 12 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 131 13 cM cm NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 14 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 131 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 131 16 telomeric telomeric NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 17 side side NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 18 Figure Figure NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 19 3 3 CD work_gukk34cj2ba2hfeeqnbcodfs6m 131 20 Age Age NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 21 estimate estimate NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 22 average average JJ work_gukk34cj2ba2hfeeqnbcodfs6m 131 23 plots plot NNS work_gukk34cj2ba2hfeeqnbcodfs6m 131 24 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 131 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 131 26 Disequilibrium Disequilibrium NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 27 Maximum Maximum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 28 Likelihood Likelihood NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 29 Estimate Estimate NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 30 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 131 31 DMLE DMLE NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 32 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 131 33 programme programme NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 34 using use VBG work_gukk34cj2ba2hfeeqnbcodfs6m 131 35 five five CD work_gukk34cj2ba2hfeeqnbcodfs6m 131 36 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 131 37 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 131 38 TESK1 tesk1 ADD work_gukk34cj2ba2hfeeqnbcodfs6m 131 39 A a NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 40 / / SYM work_gukk34cj2ba2hfeeqnbcodfs6m 131 41 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 42 SSCP SSCP NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 131 43 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 131 44 delG delg NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 45 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 131 46 D4S D4S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 47 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 131 48 AC1 AC1 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 49 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 131 50 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 131 51 XL1S XL1S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 52 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 131 53 around around IN work_gukk34cj2ba2hfeeqnbcodfs6m 131 54 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 131 55 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 56 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 57 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 131 58 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 131 59 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 60 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 131 61 Finns Finns NNP work_gukk34cj2ba2hfeeqnbcodfs6m 131 62 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 132 1 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 132 2 continuous continuous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 132 3 line line NN work_gukk34cj2ba2hfeeqnbcodfs6m 132 4 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 132 5 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 132 6 assuming assume VBG work_gukk34cj2ba2hfeeqnbcodfs6m 132 7 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 132 8 correspondence correspondence NN work_gukk34cj2ba2hfeeqnbcodfs6m 132 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 132 10 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 132 11 cM cM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 132 12 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 132 13 2.1 2.1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 132 14 Mb Mb NNS work_gukk34cj2ba2hfeeqnbcodfs6m 132 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 132 16 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 132 17 broken broken JJ work_gukk34cj2ba2hfeeqnbcodfs6m 132 18 line line NN work_gukk34cj2ba2hfeeqnbcodfs6m 132 19 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 132 20 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 132 21 correspondence correspondence NN work_gukk34cj2ba2hfeeqnbcodfs6m 132 22 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 132 23 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 132 24 cM cM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 132 25 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 132 26 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 132 27 Mb mb NN work_gukk34cj2ba2hfeeqnbcodfs6m 132 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 133 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 133 2 maximum maximum JJ work_gukk34cj2ba2hfeeqnbcodfs6m 133 3 likeli- likeli- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 133 4 hoods hood NNS work_gukk34cj2ba2hfeeqnbcodfs6m 133 5 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 133 6 t1=160 t1=160 CD work_gukk34cj2ba2hfeeqnbcodfs6m 133 7 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 133 8 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 133 9 t1=130 t1=130 CD work_gukk34cj2ba2hfeeqnbcodfs6m 133 10 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 133 11 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 133 12 respec- respec- VBG work_gukk34cj2ba2hfeeqnbcodfs6m 133 13 tively tively RB work_gukk34cj2ba2hfeeqnbcodfs6m 133 14 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 134 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 134 2 lower low JJR work_gukk34cj2ba2hfeeqnbcodfs6m 134 3 95 95 CD work_gukk34cj2ba2hfeeqnbcodfs6m 134 4 CI ci NN work_gukk34cj2ba2hfeeqnbcodfs6m 134 5 boundary boundary JJ work_gukk34cj2ba2hfeeqnbcodfs6m 134 6 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 134 7 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 134 8 around around RB work_gukk34cj2ba2hfeeqnbcodfs6m 134 9 30 30 CD work_gukk34cj2ba2hfeeqnbcodfs6m 134 10 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 134 11 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 134 12 each each DT work_gukk34cj2ba2hfeeqnbcodfs6m 134 13 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 134 14 estimate estimate NN work_gukk34cj2ba2hfeeqnbcodfs6m 134 15 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 134 16 whereas whereas IN work_gukk34cj2ba2hfeeqnbcodfs6m 134 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 134 18 upper upper JJ work_gukk34cj2ba2hfeeqnbcodfs6m 134 19 may may MD work_gukk34cj2ba2hfeeqnbcodfs6m 134 20 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 134 21 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 134 22 plotted plot VBN work_gukk34cj2ba2hfeeqnbcodfs6m 134 23 at at RB work_gukk34cj2ba2hfeeqnbcodfs6m 134 24 all all RB work_gukk34cj2ba2hfeeqnbcodfs6m 134 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 135 1 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 135 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 135 4 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 135 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 135 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 135 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 8 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 9 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 12 445 445 CD work_gukk34cj2ba2hfeeqnbcodfs6m 135 13 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 14 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 135 16 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 17 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 135 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 135 20 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 135 21 locus locus NN work_gukk34cj2ba2hfeeqnbcodfs6m 135 22 where where WRB work_gukk34cj2ba2hfeeqnbcodfs6m 135 23 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 135 24 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 135 25 out out IN work_gukk34cj2ba2hfeeqnbcodfs6m 135 26 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 135 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 135 28 five five CD work_gukk34cj2ba2hfeeqnbcodfs6m 135 29 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 135 30 suitable suitable JJ work_gukk34cj2ba2hfeeqnbcodfs6m 135 31 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 135 32 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 135 33 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 135 34 calculations calculation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 135 35 resides reside VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 135 36 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 136 1 Due due IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 2 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 3 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 136 4 vicinity vicinity NN work_gukk34cj2ba2hfeeqnbcodfs6m 136 5 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 136 7 centromere centromere NN work_gukk34cj2ba2hfeeqnbcodfs6m 136 8 it -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 136 9 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 136 10 possible possible JJ work_gukk34cj2ba2hfeeqnbcodfs6m 136 11 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 12 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 136 13 cM cM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 136 14 corresponds correspond NNS work_gukk34cj2ba2hfeeqnbcodfs6m 136 15 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 16 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 136 17 longer long JJR work_gukk34cj2ba2hfeeqnbcodfs6m 136 18 physical physical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 136 19 distance distance NN work_gukk34cj2ba2hfeeqnbcodfs6m 136 20 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 136 21 while while IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 22 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 23 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 136 24 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 136 25 time time NN work_gukk34cj2ba2hfeeqnbcodfs6m 136 26 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 136 27 we -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 136 28 have have VBP work_gukk34cj2ba2hfeeqnbcodfs6m 136 29 observed observe VBN work_gukk34cj2ba2hfeeqnbcodfs6m 136 30 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 136 31 possible possible JJ work_gukk34cj2ba2hfeeqnbcodfs6m 136 32 recombination recombination NN work_gukk34cj2ba2hfeeqnbcodfs6m 136 33 hotspot hotspot NN work_gukk34cj2ba2hfeeqnbcodfs6m 136 34 on on IN work_gukk34cj2ba2hfeeqnbcodfs6m 136 35 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 136 36 centro- centro- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 136 37 meric meric JJ work_gukk34cj2ba2hfeeqnbcodfs6m 136 38 side side NN work_gukk34cj2ba2hfeeqnbcodfs6m 136 39 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 137 1 It -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 137 2 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 137 3 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 137 4 obvious obvious JJ work_gukk34cj2ba2hfeeqnbcodfs6m 137 5 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 137 6 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 137 7 algorithm algorithm NNP work_gukk34cj2ba2hfeeqnbcodfs6m 137 8 implemented implement VBN work_gukk34cj2ba2hfeeqnbcodfs6m 137 9 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 137 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 137 11 DMLE dmle NN work_gukk34cj2ba2hfeeqnbcodfs6m 137 12 programme programme NN work_gukk34cj2ba2hfeeqnbcodfs6m 137 13 does do VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 137 14 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 137 15 converge converge VB work_gukk34cj2ba2hfeeqnbcodfs6m 137 16 very very RB work_gukk34cj2ba2hfeeqnbcodfs6m 137 17 well well RB work_gukk34cj2ba2hfeeqnbcodfs6m 137 18 when when WRB work_gukk34cj2ba2hfeeqnbcodfs6m 137 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 137 20 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 137 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 137 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 137 23 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 137 24 increased increase VBD work_gukk34cj2ba2hfeeqnbcodfs6m 137 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 138 1 Our -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 138 2 assumption assumption NN work_gukk34cj2ba2hfeeqnbcodfs6m 138 3 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 138 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 138 5 introduction introduction NN work_gukk34cj2ba2hfeeqnbcodfs6m 138 6 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 138 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 138 8 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 138 9 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 138 10 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 138 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 138 12 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 138 13 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 138 14 has have VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 138 15 occurred occur VBN work_gukk34cj2ba2hfeeqnbcodfs6m 138 16 only only RB work_gukk34cj2ba2hfeeqnbcodfs6m 138 17 once once RB work_gukk34cj2ba2hfeeqnbcodfs6m 138 18 may may MD work_gukk34cj2ba2hfeeqnbcodfs6m 138 19 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 138 20 wrong wrong JJ work_gukk34cj2ba2hfeeqnbcodfs6m 138 21 since since IN work_gukk34cj2ba2hfeeqnbcodfs6m 138 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 138 23 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 138 24 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 138 25 appears appear VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 138 26 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 138 27 be be VB work_gukk34cj2ba2hfeeqnbcodfs6m 138 28 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 138 29 worldwide worldwide RB work_gukk34cj2ba2hfeeqnbcodfs6m 138 30 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 138 31 see see VB work_gukk34cj2ba2hfeeqnbcodfs6m 138 32 below below RB work_gukk34cj2ba2hfeeqnbcodfs6m 138 33 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 138 34 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 139 1 On on IN work_gukk34cj2ba2hfeeqnbcodfs6m 139 2 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 139 3 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 139 4 hand hand NN work_gukk34cj2ba2hfeeqnbcodfs6m 139 5 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 139 6 solitary solitary JJ work_gukk34cj2ba2hfeeqnbcodfs6m 139 7 intro- intro- NN work_gukk34cj2ba2hfeeqnbcodfs6m 139 8 duction duction NN work_gukk34cj2ba2hfeeqnbcodfs6m 139 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 139 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 139 11 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 139 12 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 139 13 strongly strongly RB work_gukk34cj2ba2hfeeqnbcodfs6m 139 14 favoured favour VBN work_gukk34cj2ba2hfeeqnbcodfs6m 139 15 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 139 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 139 17 length length NN work_gukk34cj2ba2hfeeqnbcodfs6m 139 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 139 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 139 20 shared shared JJ work_gukk34cj2ba2hfeeqnbcodfs6m 139 21 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 139 22 segregating segregating NN work_gukk34cj2ba2hfeeqnbcodfs6m 139 23 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 139 24 Finns Finns NNP work_gukk34cj2ba2hfeeqnbcodfs6m 139 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 140 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 140 2 means means NN work_gukk34cj2ba2hfeeqnbcodfs6m 140 3 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 140 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 140 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 140 6 moments moment NNS work_gukk34cj2ba2hfeeqnbcodfs6m 140 7 estimator estimator NN work_gukk34cj2ba2hfeeqnbcodfs6m 140 8 calculations calculation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 140 9 suffer suffer VBP work_gukk34cj2ba2hfeeqnbcodfs6m 140 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 140 11 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 140 12 reservations reservation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 140 13 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 140 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 140 15 furthermore furthermore RB work_gukk34cj2ba2hfeeqnbcodfs6m 140 16 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 140 17 do do VBP work_gukk34cj2ba2hfeeqnbcodfs6m 140 18 not not RB work_gukk34cj2ba2hfeeqnbcodfs6m 140 19 account account VB work_gukk34cj2ba2hfeeqnbcodfs6m 140 20 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 140 21 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 140 22 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 140 23 parameters parameter NNS work_gukk34cj2ba2hfeeqnbcodfs6m 140 24 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 140 25 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 140 26 even even RB work_gukk34cj2ba2hfeeqnbcodfs6m 140 27 more more RBR work_gukk34cj2ba2hfeeqnbcodfs6m 140 28 sensitive sensitive JJ work_gukk34cj2ba2hfeeqnbcodfs6m 140 29 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 140 30 assumed assume VBN work_gukk34cj2ba2hfeeqnbcodfs6m 140 31 recombination recombination NN work_gukk34cj2ba2hfeeqnbcodfs6m 140 32 rate rate NN work_gukk34cj2ba2hfeeqnbcodfs6m 140 33 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 141 1 As as IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 2 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 3 independent independent JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 4 observa- observa- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 5 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 6 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 141 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 8 birthplaces birthplace NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 9 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 10 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 11 great great JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 12 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 141 13 grandparents grandparent NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 14 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 15 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 141 16 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 17 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 141 18 distributed distribute VBN work_gukk34cj2ba2hfeeqnbcodfs6m 141 19 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 21 early early JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 22 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 141 23 late late JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 24 settlement settlement NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 25 regions region NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 26 relatively relatively RB work_gukk34cj2ba2hfeeqnbcodfs6m 141 27 evenly evenly RB work_gukk34cj2ba2hfeeqnbcodfs6m 141 28 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 141 29 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 141 30 strengthen strengthen VB work_gukk34cj2ba2hfeeqnbcodfs6m 141 31 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 32 assumption assumption NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 33 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 34 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 35 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 36 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 37 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 141 38 present present JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 39 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 40 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 41 time time NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 42 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 43 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 44 beginning beginning NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 45 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 46 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 47 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 48 expansion expansion NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 49 some some DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 50 80 80 CD work_gukk34cj2ba2hfeeqnbcodfs6m 141 51 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 141 52 100 100 CD work_gukk34cj2ba2hfeeqnbcodfs6m 141 53 generations generation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 54 ago.2,17 ago.2,17 CD work_gukk34cj2ba2hfeeqnbcodfs6m 141 55 Similarly similarly RB work_gukk34cj2ba2hfeeqnbcodfs6m 141 56 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 141 57 our -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 141 58 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 59 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 60 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 141 61 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 141 62 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 63 distribution distribution NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 64 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 65 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 66 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 67 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 68 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 141 69 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 141 70 allow allow VB work_gukk34cj2ba2hfeeqnbcodfs6m 141 71 us -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 141 72 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 141 73 assume assume VB work_gukk34cj2ba2hfeeqnbcodfs6m 141 74 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 75 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 76 four four CD work_gukk34cj2ba2hfeeqnbcodfs6m 141 77 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 78 minor minor JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 79 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 80 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 141 81 younger young JJR work_gukk34cj2ba2hfeeqnbcodfs6m 141 82 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 83 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 84 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 85 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 86 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 141 87 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 88 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 89 local local JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 90 enrichment enrichment NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 91 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 92 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 141 93 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 94 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 95 western western JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 96 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 141 97 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 141 98 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 141 99 at at IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 100 least least JJS work_gukk34cj2ba2hfeeqnbcodfs6m 141 101 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 102 part part NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 103 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 141 104 due due IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 105 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 106 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 107 enrichment enrichment NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 108 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 109 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 110 rare rare JJ work_gukk34cj2ba2hfeeqnbcodfs6m 141 111 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 141 112 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 141 113 that that DT work_gukk34cj2ba2hfeeqnbcodfs6m 141 114 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 141 115 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 142 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 142 2 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 142 3 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 142 4 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 142 5 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 142 6 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 142 7 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 142 8 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 142 9 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 142 10 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 142 11 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 142 12 48 48 CD work_gukk34cj2ba2hfeeqnbcodfs6m 142 13 % % NN work_gukk34cj2ba2hfeeqnbcodfs6m 142 14 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 142 15 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 142 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 142 17 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 142 18 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 142 19 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 142 20 44 44 CD work_gukk34cj2ba2hfeeqnbcodfs6m 142 21 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 142 22 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 142 23 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 142 24 countries country NNS work_gukk34cj2ba2hfeeqnbcodfs6m 142 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 143 1 Patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 143 2 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 143 3 13 13 CD work_gukk34cj2ba2hfeeqnbcodfs6m 143 4 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 143 5 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 143 6 homozy- homozy- FW work_gukk34cj2ba2hfeeqnbcodfs6m 143 7 gous gous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 143 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 143 9 whereas whereas IN work_gukk34cj2ba2hfeeqnbcodfs6m 143 10 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 143 11 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 143 12 15 15 CD work_gukk34cj2ba2hfeeqnbcodfs6m 143 13 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 143 14 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 143 15 heterozygous heterozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 143 16 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 143 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 143 18 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 19 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 143 20 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 143 21 representing representing NN work_gukk34cj2ba2hfeeqnbcodfs6m 143 22 nationalities nationality NNS work_gukk34cj2ba2hfeeqnbcodfs6m 143 23 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 143 24 Europe Europe NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 25 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 143 26 North North NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 27 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 143 28 South South NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 29 America America NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 30 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 143 31 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 143 32 Near Near NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 33 East East NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 34 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 143 35 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 143 36 Australia Australia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 143 37 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 144 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 144 2 ethnic ethnic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 144 3 background background NN work_gukk34cj2ba2hfeeqnbcodfs6m 144 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 144 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 144 6 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 144 7 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 144 8 America America NNP work_gukk34cj2ba2hfeeqnbcodfs6m 144 9 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 144 10 Australia Australia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 144 11 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 144 12 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 144 13 particular particular JJ work_gukk34cj2ba2hfeeqnbcodfs6m 144 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 144 15 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 144 16 often often RB work_gukk34cj2ba2hfeeqnbcodfs6m 144 17 European european JJ work_gukk34cj2ba2hfeeqnbcodfs6m 144 18 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 144 19 mixed mixed JJ work_gukk34cj2ba2hfeeqnbcodfs6m 144 20 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 145 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 145 2 all all DT work_gukk34cj2ba2hfeeqnbcodfs6m 145 3 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 145 4 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 145 5 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 145 6 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 145 7 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 145 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 145 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 145 10 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 145 11 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 145 12 segregates segregate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 145 13 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 145 14 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 145 15 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 145 16 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 145 17 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 145 18 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 145 19 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 145 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 145 21 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 145 22 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 145 23 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 146 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 146 2 23 23 CD work_gukk34cj2ba2hfeeqnbcodfs6m 146 3 out out IN work_gukk34cj2ba2hfeeqnbcodfs6m 146 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 146 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 146 6 27 27 CD work_gukk34cj2ba2hfeeqnbcodfs6m 146 7 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 146 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 146 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 146 10 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 146 11 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 146 12 expands expand VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 146 13 over over IN work_gukk34cj2ba2hfeeqnbcodfs6m 146 14 60 60 CD work_gukk34cj2ba2hfeeqnbcodfs6m 146 15 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 146 16 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 147 1 Interestingly interestingly RB work_gukk34cj2ba2hfeeqnbcodfs6m 147 2 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 147 3 one one CD work_gukk34cj2ba2hfeeqnbcodfs6m 147 4 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 147 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 147 6 homozygous homozygous JJ work_gukk34cj2ba2hfeeqnbcodfs6m 147 7 US US NNP work_gukk34cj2ba2hfeeqnbcodfs6m 147 8 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 147 9 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 147 10 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 147 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 148 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 148 2 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 148 3 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 148 4 patient patient NN work_gukk34cj2ba2hfeeqnbcodfs6m 148 5 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 148 6 two two CD work_gukk34cj2ba2hfeeqnbcodfs6m 148 7 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 148 8 CEPH CEPH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 148 9 control control NN work_gukk34cj2ba2hfeeqnbcodfs6m 148 10 chromosomes chromosome NNS work_gukk34cj2ba2hfeeqnbcodfs6m 148 11 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 148 12 which which WDT work_gukk34cj2ba2hfeeqnbcodfs6m 148 13 were be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 148 14 available available JJ work_gukk34cj2ba2hfeeqnbcodfs6m 148 15 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 148 16 genotyping genotype VBG work_gukk34cj2ba2hfeeqnbcodfs6m 148 17 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 148 18 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 148 19 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 148 20 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 148 21 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 148 22 same same JJ work_gukk34cj2ba2hfeeqnbcodfs6m 148 23 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 148 24 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 148 25 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 148 26 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 148 27 haplotype haplotype NN work_gukk34cj2ba2hfeeqnbcodfs6m 148 28 extending extend VBG work_gukk34cj2ba2hfeeqnbcodfs6m 148 29 over over IN work_gukk34cj2ba2hfeeqnbcodfs6m 148 30 100 100 CD work_gukk34cj2ba2hfeeqnbcodfs6m 148 31 kb kb NN work_gukk34cj2ba2hfeeqnbcodfs6m 148 32 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 148 33 around around IN work_gukk34cj2ba2hfeeqnbcodfs6m 148 34 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 148 35 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 148 36 locus locus NN work_gukk34cj2ba2hfeeqnbcodfs6m 148 37 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 149 1 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 149 2 more more RBR work_gukk34cj2ba2hfeeqnbcodfs6m 149 3 extensive extensive JJ work_gukk34cj2ba2hfeeqnbcodfs6m 149 4 collection collection NN work_gukk34cj2ba2hfeeqnbcodfs6m 149 5 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 149 6 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 149 7 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 149 8 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 149 9 needed need VBN work_gukk34cj2ba2hfeeqnbcodfs6m 149 10 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 149 11 order order NN work_gukk34cj2ba2hfeeqnbcodfs6m 149 12 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 149 13 find find VB work_gukk34cj2ba2hfeeqnbcodfs6m 149 14 out out RP work_gukk34cj2ba2hfeeqnbcodfs6m 149 15 if if IN work_gukk34cj2ba2hfeeqnbcodfs6m 149 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 149 17 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 149 18 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 149 19 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 149 20 accounts account VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 149 21 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 149 22 all all PDT work_gukk34cj2ba2hfeeqnbcodfs6m 149 23 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 149 24 frequent frequent JJ work_gukk34cj2ba2hfeeqnbcodfs6m 149 25 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 149 26 cases case NNS work_gukk34cj2ba2hfeeqnbcodfs6m 149 27 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 149 28 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 149 29 or or CC work_gukk34cj2ba2hfeeqnbcodfs6m 149 30 whether whether IN work_gukk34cj2ba2hfeeqnbcodfs6m 149 31 several several JJ work_gukk34cj2ba2hfeeqnbcodfs6m 149 32 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 149 33 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 149 34 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 149 35 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 149 36 involved involve VBN work_gukk34cj2ba2hfeeqnbcodfs6m 149 37 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 149 38 that that DT work_gukk34cj2ba2hfeeqnbcodfs6m 149 39 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 149 40 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 150 1 In in IN work_gukk34cj2ba2hfeeqnbcodfs6m 150 2 conclusion conclusion NN work_gukk34cj2ba2hfeeqnbcodfs6m 150 3 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 150 4 different different JJ work_gukk34cj2ba2hfeeqnbcodfs6m 150 5 insertions insertion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 150 6 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 150 7 duplications duplication NNS work_gukk34cj2ba2hfeeqnbcodfs6m 150 8 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 150 9 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 150 10 promoter promoter NN work_gukk34cj2ba2hfeeqnbcodfs6m 150 11 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 150 12 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 150 13 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 150 14 large large JJ work_gukk34cj2ba2hfeeqnbcodfs6m 150 15 number number NN work_gukk34cj2ba2hfeeqnbcodfs6m 150 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 150 17 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 150 18 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 150 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 150 20 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 150 21 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 150 22 can can MD work_gukk34cj2ba2hfeeqnbcodfs6m 150 23 cause cause VB work_gukk34cj2ba2hfeeqnbcodfs6m 150 24 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 150 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 151 1 Our -PRON- PRP$ work_gukk34cj2ba2hfeeqnbcodfs6m 151 2 findings finding NNS work_gukk34cj2ba2hfeeqnbcodfs6m 151 3 clearly clearly RB work_gukk34cj2ba2hfeeqnbcodfs6m 151 4 support support VBP work_gukk34cj2ba2hfeeqnbcodfs6m 151 5 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 151 6 hypothesis hypothesis NN work_gukk34cj2ba2hfeeqnbcodfs6m 151 7 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 151 8 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 151 9 single single JJ work_gukk34cj2ba2hfeeqnbcodfs6m 151 10 ancient ancient NN work_gukk34cj2ba2hfeeqnbcodfs6m 151 11 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 151 12 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 151 13 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 151 14 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 151 15 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 151 16 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 151 17 causes cause VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 151 18 most most JJS work_gukk34cj2ba2hfeeqnbcodfs6m 151 19 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 151 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 151 21 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 151 22 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 151 23 cases case NNS work_gukk34cj2ba2hfeeqnbcodfs6m 151 24 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 151 25 contributes contribute VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 151 26 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 151 27 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 151 28 majority majority NN work_gukk34cj2ba2hfeeqnbcodfs6m 151 29 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 151 30 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 151 31 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 151 32 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 151 33 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 151 34 cases case NNS work_gukk34cj2ba2hfeeqnbcodfs6m 151 35 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 151 36 possibly possibly RB work_gukk34cj2ba2hfeeqnbcodfs6m 151 37 also also RB work_gukk34cj2ba2hfeeqnbcodfs6m 151 38 including include VBG work_gukk34cj2ba2hfeeqnbcodfs6m 151 39 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 151 40 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 151 41 enrichment enrichment NN work_gukk34cj2ba2hfeeqnbcodfs6m 151 42 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 152 1 It -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 152 2 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 152 3 very very RB work_gukk34cj2ba2hfeeqnbcodfs6m 152 4 likely likely JJ work_gukk34cj2ba2hfeeqnbcodfs6m 152 5 that that IN work_gukk34cj2ba2hfeeqnbcodfs6m 152 6 all all DT work_gukk34cj2ba2hfeeqnbcodfs6m 152 7 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 152 8 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 152 9 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 152 10 70 70 CD work_gukk34cj2ba2hfeeqnbcodfs6m 152 11 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 152 12 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 152 13 reported report VBN work_gukk34cj2ba2hfeeqnbcodfs6m 152 14 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 152 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 152 16 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 152 17 represent represent VBP work_gukk34cj2ba2hfeeqnbcodfs6m 152 18 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 152 19 single single JJ work_gukk34cj2ba2hfeeqnbcodfs6m 152 20 occurrence occurrence NN work_gukk34cj2ba2hfeeqnbcodfs6m 152 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 152 22 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 152 23 base base NN work_gukk34cj2ba2hfeeqnbcodfs6m 152 24 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 152 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 153 1 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 153 2 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 153 3 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 153 4 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 153 5 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 153 6 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 153 7 introduced introduce VBN work_gukk34cj2ba2hfeeqnbcodfs6m 153 8 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 153 9 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 153 10 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 153 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 153 12 founder founder NN work_gukk34cj2ba2hfeeqnbcodfs6m 153 13 individuals individual NNS work_gukk34cj2ba2hfeeqnbcodfs6m 153 14 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 153 15 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 153 16 highly highly RB work_gukk34cj2ba2hfeeqnbcodfs6m 153 17 enriched enrich VBN work_gukk34cj2ba2hfeeqnbcodfs6m 153 18 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 153 19 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 153 20 current current JJ work_gukk34cj2ba2hfeeqnbcodfs6m 153 21 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 153 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 154 1 Acknowledgements acknowledgement NNS work_gukk34cj2ba2hfeeqnbcodfs6m 154 2 We -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 154 3 acknowledge acknowledge VBP work_gukk34cj2ba2hfeeqnbcodfs6m 154 4 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 154 5 following follow VBG work_gukk34cj2ba2hfeeqnbcodfs6m 154 6 clinicians clinician NNS work_gukk34cj2ba2hfeeqnbcodfs6m 154 7 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 154 8 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 154 9 counselors counselor NNS work_gukk34cj2ba2hfeeqnbcodfs6m 154 10 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 154 11 sending send VBG work_gukk34cj2ba2hfeeqnbcodfs6m 154 12 clinical clinical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 154 13 data datum NNS work_gukk34cj2ba2hfeeqnbcodfs6m 154 14 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 154 15 patient patient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 154 16 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 154 17 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 154 18 this this DT work_gukk34cj2ba2hfeeqnbcodfs6m 154 19 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 154 20 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 154 21 L l NN work_gukk34cj2ba2hfeeqnbcodfs6m 154 22 Adès adè NNS work_gukk34cj2ba2hfeeqnbcodfs6m 154 23 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 24 Australia Australia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 25 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 26 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 27 Bonaventure Bonaventure NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 28 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 29 France France NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 30 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 31 Z Z NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 32 Borozowitz Borozowitz NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 33 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 34 Israel Israel NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 35 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 36 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 37 Boudames Boudames NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 38 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 39 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 40 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 41 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 42 Campbell Campbell NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 43 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 44 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 45 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 46 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 154 47 Castriota Castriota NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 48 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 154 49 Scanderbeg Scanderbeg NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 50 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 51 Italy Italy NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 52 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 53 D D NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 54 Chitayat Chitayat NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 55 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 56 Canada Canada NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 57 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 58 DH DH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 59 Cohn Cohn NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 60 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 61 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 62 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 63 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 64 Conley Conley NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 65 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 66 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 67 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 68 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 69 Costa Costa NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 70 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 71 Canada Canada NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 72 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 73 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 154 74 de de FW work_gukk34cj2ba2hfeeqnbcodfs6m 154 75 Oliveira Oliveira NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 76 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 77 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 78 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 79 CR CR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 80 Dolan Dolan NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 81 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 82 UK UK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 83 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 84 F F NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 85 Elmslie Elmslie NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 86 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 87 UK UK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 88 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 89 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 90 Freisinger Freisinger NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 91 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 92 Germany Germany NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 93 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 94 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 95 Jobim Jobim NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 96 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 97 Brazil Brazil NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 98 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 99 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 100 Johnson Johnson NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 101 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 102 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 103 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 104 H. H. NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 105 Kayserili Kayserili NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 106 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 107 Turkey Turkey NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 108 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 109 S S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 110 Langlois Langlois NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 111 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 112 Canada Canada NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 113 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 114 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 115 Mattheson Mattheson NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 116 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 117 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 118 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 119 W W NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 120 Newman Newman NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 121 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 122 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 123 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 124 I -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 154 125 Pellier pellier RBR work_gukk34cj2ba2hfeeqnbcodfs6m 154 126 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 127 France France NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 128 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 129 R R NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 130 Saviriayan Saviriayan NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 131 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 132 Australia Australia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 133 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 134 C C NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 135 Scott Scott NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 136 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 137 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 138 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 139 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 140 Simon Simon NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 141 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 142 Germany Germany NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 143 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 144 S S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 145 Smithson Smithson NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 146 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 147 UK UK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 148 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 149 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 150 Splitt Splitt NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 151 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 152 UK UK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 153 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 154 E E NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 155 Steichen Steichen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 156 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 157 Austria Austria NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 158 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 159 A A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 160 Superti Superti NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 161 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 154 162 Furga Furga NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 163 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 164 Switzerland Switzerland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 165 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 166 I -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 154 167 van van MD work_gukk34cj2ba2hfeeqnbcodfs6m 154 168 der der XX work_gukk34cj2ba2hfeeqnbcodfs6m 154 169 Burgt Burgt NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 170 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 171 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 154 172 Netherlands Netherlands NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 173 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 174 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 175 van van NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 176 Maldergem Maldergem NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 177 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 178 Belgium Belgium NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 179 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 180 W W NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 181 Wilcox Wilcox NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 182 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 183 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 184 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 185 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 186 Wilson Wilson NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 187 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 188 UK UK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 189 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 190 R R NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 191 Winter Winter NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 192 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 193 UK UK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 194 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 195 B B NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 196 Zabel Zabel NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 197 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 198 Germany Germany NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 199 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 200 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 201 Zack Zack NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 202 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 154 203 UK UK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 154 204 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 155 1 Professor Professor NNP work_gukk34cj2ba2hfeeqnbcodfs6m 155 2 Albert Albert NNP work_gukk34cj2ba2hfeeqnbcodfs6m 155 3 de de NNP work_gukk34cj2ba2hfeeqnbcodfs6m 155 4 la la NNP work_gukk34cj2ba2hfeeqnbcodfs6m 155 5 Chapelle Chapelle NNP work_gukk34cj2ba2hfeeqnbcodfs6m 155 6 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 155 7 thanked thank VBN work_gukk34cj2ba2hfeeqnbcodfs6m 155 8 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 155 9 useful useful JJ work_gukk34cj2ba2hfeeqnbcodfs6m 155 10 discussions discussion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 155 11 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 155 12 critical critical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 155 13 reading reading NN work_gukk34cj2ba2hfeeqnbcodfs6m 155 14 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 155 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 155 16 manuscript manuscript NN work_gukk34cj2ba2hfeeqnbcodfs6m 155 17 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 156 1 Ahmed Ahmed NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 2 Mohamed Mohamed NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 3 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 4 Hanna Hanna NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 5 Mäkelä Mäkelä NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 6 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 7 Katarina Katarina NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 8 Pelin Pelin NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 9 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 156 10 Riika Riika NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 11 Salmela Salmela NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 12 are be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 156 13 acknowledged acknowledge VBN work_gukk34cj2ba2hfeeqnbcodfs6m 156 14 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 156 15 laboratory laboratory NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 16 assistance assistance NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 17 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 156 18 collaborative collaborative JJ work_gukk34cj2ba2hfeeqnbcodfs6m 156 19 help help NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 20 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 156 21 Sinikka Sinikka NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 22 Lindh Lindh NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 23 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 156 24 help help NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 25 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 156 26 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 156 27 genealogical genealogical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 156 28 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 29 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 156 30 drawing draw VBG work_gukk34cj2ba2hfeeqnbcodfs6m 156 31 Figures figure NNS work_gukk34cj2ba2hfeeqnbcodfs6m 156 32 2B 2B NNS work_gukk34cj2ba2hfeeqnbcodfs6m 156 33 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 156 34 C. C. NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 35 This this DT work_gukk34cj2ba2hfeeqnbcodfs6m 156 36 work work NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 37 was be VBD work_gukk34cj2ba2hfeeqnbcodfs6m 156 38 financially financially RB work_gukk34cj2ba2hfeeqnbcodfs6m 156 39 supported support VBN work_gukk34cj2ba2hfeeqnbcodfs6m 156 40 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 156 41 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 156 42 March March NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 43 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 156 44 Dimes Dimes NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 45 Birth Birth NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 46 Defects Defects NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 47 Foundation Foundation NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 48 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 156 49 6-FY99 6-FY99 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 50 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 156 51 586 586 CD work_gukk34cj2ba2hfeeqnbcodfs6m 156 52 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 156 53 6-FY00 6-fy00 CD work_gukk34cj2ba2hfeeqnbcodfs6m 156 54 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 156 55 294 294 CD work_gukk34cj2ba2hfeeqnbcodfs6m 156 56 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 156 57 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 58 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 156 59 Academy Academy NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 60 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 156 61 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 62 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 156 63 grant grant VB work_gukk34cj2ba2hfeeqnbcodfs6m 156 64 38826 38826 CD work_gukk34cj2ba2hfeeqnbcodfs6m 156 65 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 156 66 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 67 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 68 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 69 ’s ’s POS work_gukk34cj2ba2hfeeqnbcodfs6m 156 70 Research Research NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 71 Funds Funds NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 156 72 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 73 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 156 74 Helsinki Helsinki NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 75 University University NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 76 Central Central NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 77 Hospital Hospital NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 78 Fund Fund NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 79 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 80 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 156 81 Ulla Ulla NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 82 Hjelt Hjelt NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 83 Fund Fund NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 84 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 85 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 86 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 156 87 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 156 88 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 156 89 NIH NIH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 90 Program Program NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 91 Project Project NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 92 grant grant NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 93 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 156 94 2 2 CD work_gukk34cj2ba2hfeeqnbcodfs6m 156 95 PO1 PO1 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 156 96 HD22657 hd22657 NN work_gukk34cj2ba2hfeeqnbcodfs6m 156 97 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 156 98 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 157 1 References reference NNS work_gukk34cj2ba2hfeeqnbcodfs6m 157 2 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 157 3 McKusick McKusick NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 4 VA VA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 5 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 157 6 Eldridge Eldridge NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 7 R R NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 157 9 Hostetler Hostetler NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 10 JA JA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 11 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 157 12 Ruangwit Ruangwit NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 13 U U NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 157 15 Egeland Egeland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 16 JA JA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 17 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 157 18 Dwarfism dwarfism NN work_gukk34cj2ba2hfeeqnbcodfs6m 157 19 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 157 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 157 21 Amish Amish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 157 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 158 1 II ii CD work_gukk34cj2ba2hfeeqnbcodfs6m 158 2 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 159 1 Cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 159 2 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 159 3 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 159 4 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 159 5 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 160 1 Bull Bull NNP work_gukk34cj2ba2hfeeqnbcodfs6m 160 2 Johns Johns NNP work_gukk34cj2ba2hfeeqnbcodfs6m 160 3 Hopkins Hopkins NNP work_gukk34cj2ba2hfeeqnbcodfs6m 160 4 Hosp Hosp NNP work_gukk34cj2ba2hfeeqnbcodfs6m 160 5 1965 1965 CD work_gukk34cj2ba2hfeeqnbcodfs6m 160 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 160 7 116 116 CD work_gukk34cj2ba2hfeeqnbcodfs6m 160 8 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 160 9 231 231 CD work_gukk34cj2ba2hfeeqnbcodfs6m 160 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 160 11 272 272 CD work_gukk34cj2ba2hfeeqnbcodfs6m 160 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 161 1 2 2 LS work_gukk34cj2ba2hfeeqnbcodfs6m 161 2 Mäkitie Mäkitie NNS work_gukk34cj2ba2hfeeqnbcodfs6m 161 3 O o NN work_gukk34cj2ba2hfeeqnbcodfs6m 161 4 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 161 5 Cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 161 6 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 161 7 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 161 8 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 161 9 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 161 10 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 161 11 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 161 12 epidemiological epidemiological JJ work_gukk34cj2ba2hfeeqnbcodfs6m 161 13 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 161 14 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 161 15 aspects aspect NNS work_gukk34cj2ba2hfeeqnbcodfs6m 161 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 161 17 107 107 CD work_gukk34cj2ba2hfeeqnbcodfs6m 161 18 Patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 161 19 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 162 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 162 2 Med Med NNP work_gukk34cj2ba2hfeeqnbcodfs6m 162 3 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 162 4 1992 1992 CD work_gukk34cj2ba2hfeeqnbcodfs6m 162 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 162 6 29 29 CD work_gukk34cj2ba2hfeeqnbcodfs6m 162 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 162 8 652 652 CD work_gukk34cj2ba2hfeeqnbcodfs6m 162 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 162 10 655 655 CD work_gukk34cj2ba2hfeeqnbcodfs6m 162 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 163 1 3 3 LS work_gukk34cj2ba2hfeeqnbcodfs6m 163 2 Mäkitie Mäkitie NNS work_gukk34cj2ba2hfeeqnbcodfs6m 163 3 O o UH work_gukk34cj2ba2hfeeqnbcodfs6m 163 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 163 5 Kaitila Kaitila NNP work_gukk34cj2ba2hfeeqnbcodfs6m 163 6 I -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 163 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 163 8 Cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 163 9 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 163 10 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 163 11 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 163 12 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 163 13 clinical clinical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 163 14 manifesta- manifesta- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 163 15 tions tion NNS work_gukk34cj2ba2hfeeqnbcodfs6m 163 16 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 163 17 108 108 CD work_gukk34cj2ba2hfeeqnbcodfs6m 163 18 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 163 19 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 163 20 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 164 1 Eur Eur NNP work_gukk34cj2ba2hfeeqnbcodfs6m 164 2 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 164 3 Pediatr Pediatr NNP work_gukk34cj2ba2hfeeqnbcodfs6m 164 4 1993 1993 CD work_gukk34cj2ba2hfeeqnbcodfs6m 164 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 164 6 152 152 CD work_gukk34cj2ba2hfeeqnbcodfs6m 164 7 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 164 8 211 211 CD work_gukk34cj2ba2hfeeqnbcodfs6m 164 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 164 10 217 217 CD work_gukk34cj2ba2hfeeqnbcodfs6m 164 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 165 1 4 4 LS work_gukk34cj2ba2hfeeqnbcodfs6m 165 2 Mäkitie Mäkitie NNS work_gukk34cj2ba2hfeeqnbcodfs6m 165 3 O o UH work_gukk34cj2ba2hfeeqnbcodfs6m 165 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 165 5 Pukkala Pukkala NNP work_gukk34cj2ba2hfeeqnbcodfs6m 165 6 E E NNP work_gukk34cj2ba2hfeeqnbcodfs6m 165 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 165 8 Teppo Teppo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 165 9 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 165 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 165 11 Kaitila Kaitila NNP work_gukk34cj2ba2hfeeqnbcodfs6m 165 12 I -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 165 13 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 165 14 Increased increase VBN work_gukk34cj2ba2hfeeqnbcodfs6m 165 15 incidence incidence NN work_gukk34cj2ba2hfeeqnbcodfs6m 165 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 165 17 cancer cancer NN work_gukk34cj2ba2hfeeqnbcodfs6m 165 18 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 165 19 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 165 20 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 165 21 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 165 22 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 165 23 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 165 24 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 166 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 166 2 Pediatr Pediatr NNP work_gukk34cj2ba2hfeeqnbcodfs6m 166 3 1999 1999 CD work_gukk34cj2ba2hfeeqnbcodfs6m 166 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 166 5 134 134 CD work_gukk34cj2ba2hfeeqnbcodfs6m 166 6 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 166 7 315 315 CD work_gukk34cj2ba2hfeeqnbcodfs6m 166 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 166 9 318 318 CD work_gukk34cj2ba2hfeeqnbcodfs6m 166 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 167 1 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 167 2 Mäkitie Mäkitie NNS work_gukk34cj2ba2hfeeqnbcodfs6m 167 3 O o UH work_gukk34cj2ba2hfeeqnbcodfs6m 167 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 167 5 Pukkala Pukkala NNP work_gukk34cj2ba2hfeeqnbcodfs6m 167 6 E E NNP work_gukk34cj2ba2hfeeqnbcodfs6m 167 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 167 8 Kaitila Kaitila NNP work_gukk34cj2ba2hfeeqnbcodfs6m 167 9 I -PRON- PRP work_gukk34cj2ba2hfeeqnbcodfs6m 167 10 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 167 11 Increased increase VBN work_gukk34cj2ba2hfeeqnbcodfs6m 167 12 mortality mortality NN work_gukk34cj2ba2hfeeqnbcodfs6m 167 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 167 14 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 167 15 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 167 16 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 167 17 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 167 18 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 168 1 Arch Arch NNP work_gukk34cj2ba2hfeeqnbcodfs6m 168 2 Dis Dis NNP work_gukk34cj2ba2hfeeqnbcodfs6m 168 3 Child Child NNP work_gukk34cj2ba2hfeeqnbcodfs6m 168 4 2001 2001 CD work_gukk34cj2ba2hfeeqnbcodfs6m 168 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 168 6 84 84 CD work_gukk34cj2ba2hfeeqnbcodfs6m 168 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 168 8 65 65 CD work_gukk34cj2ba2hfeeqnbcodfs6m 168 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 168 10 67 67 CD work_gukk34cj2ba2hfeeqnbcodfs6m 168 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 169 1 6 6 CD work_gukk34cj2ba2hfeeqnbcodfs6m 169 2 Mäkitie Mäkitie NNS work_gukk34cj2ba2hfeeqnbcodfs6m 169 3 OM OM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 169 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 169 5 Tapanainen Tapanainen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 169 6 OJ OJ NNP work_gukk34cj2ba2hfeeqnbcodfs6m 169 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 169 8 Dunkel Dunkel NNP work_gukk34cj2ba2hfeeqnbcodfs6m 169 9 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 169 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 169 11 Siimes Siimes NNP work_gukk34cj2ba2hfeeqnbcodfs6m 169 12 MA MA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 169 13 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 169 14 Impaired impair VBN work_gukk34cj2ba2hfeeqnbcodfs6m 169 15 sper- sper- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 169 16 matogenesis matogenesis NN work_gukk34cj2ba2hfeeqnbcodfs6m 169 17 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 169 18 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 169 19 unrecognized unrecognized JJ work_gukk34cj2ba2hfeeqnbcodfs6m 169 20 feature feature NN work_gukk34cj2ba2hfeeqnbcodfs6m 169 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 169 22 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 169 23 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 169 24 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 169 25 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 169 26 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 170 1 Ann Ann NNP work_gukk34cj2ba2hfeeqnbcodfs6m 170 2 Med Med NNP work_gukk34cj2ba2hfeeqnbcodfs6m 170 3 2001 2001 CD work_gukk34cj2ba2hfeeqnbcodfs6m 170 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 170 5 33 33 CD work_gukk34cj2ba2hfeeqnbcodfs6m 170 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 170 7 201 201 CD work_gukk34cj2ba2hfeeqnbcodfs6m 170 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 170 9 205 205 CD work_gukk34cj2ba2hfeeqnbcodfs6m 170 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 171 1 7 7 CD work_gukk34cj2ba2hfeeqnbcodfs6m 171 2 Sulisalo Sulisalo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 3 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 171 5 Francomano Francomano NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 6 CA CA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 171 8 Sistonen Sistonen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 9 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 10 et et NN work_gukk34cj2ba2hfeeqnbcodfs6m 171 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 171 13 High high JJ work_gukk34cj2ba2hfeeqnbcodfs6m 171 14 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 171 15 resolution resolution NN work_gukk34cj2ba2hfeeqnbcodfs6m 171 16 genet- genet- NN work_gukk34cj2ba2hfeeqnbcodfs6m 171 17 ic ic NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 18 mapping mapping NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 19 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 171 20 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 171 21 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 171 22 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 171 23 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 171 24 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 171 25 ( ( -LRB- work_gukk34cj2ba2hfeeqnbcodfs6m 171 26 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 171 27 ) ) -RRB- work_gukk34cj2ba2hfeeqnbcodfs6m 171 28 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 171 29 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 171 30 Amish amish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 171 31 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 171 32 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 171 33 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 171 34 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 172 1 Genomics genomic NNS work_gukk34cj2ba2hfeeqnbcodfs6m 172 2 1994 1994 CD work_gukk34cj2ba2hfeeqnbcodfs6m 172 3 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 172 4 20 20 CD work_gukk34cj2ba2hfeeqnbcodfs6m 172 5 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 172 6 347 347 CD work_gukk34cj2ba2hfeeqnbcodfs6m 172 7 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 172 8 353 353 CD work_gukk34cj2ba2hfeeqnbcodfs6m 172 9 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 173 1 8 8 CD work_gukk34cj2ba2hfeeqnbcodfs6m 173 2 Sulisalo Sulisalo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 3 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 173 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 173 5 Sistonen Sistonen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 6 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 173 8 Hästbacka Hästbacka NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 9 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 173 13 Cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 173 14 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 173 15 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 173 16 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 173 17 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 173 18 assigned assign VBN work_gukk34cj2ba2hfeeqnbcodfs6m 173 19 to to TO work_gukk34cj2ba2hfeeqnbcodfs6m 173 20 chromosome chromosome VB work_gukk34cj2ba2hfeeqnbcodfs6m 173 21 9 9 CD work_gukk34cj2ba2hfeeqnbcodfs6m 173 22 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 173 23 linkage linkage NN work_gukk34cj2ba2hfeeqnbcodfs6m 173 24 analysis analysis NN work_gukk34cj2ba2hfeeqnbcodfs6m 173 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 174 1 Nat Nat NNP work_gukk34cj2ba2hfeeqnbcodfs6m 174 2 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 174 3 1993 1993 CD work_gukk34cj2ba2hfeeqnbcodfs6m 174 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 174 5 3 3 CD work_gukk34cj2ba2hfeeqnbcodfs6m 174 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 174 7 338 338 CD work_gukk34cj2ba2hfeeqnbcodfs6m 174 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 174 9 341 341 CD work_gukk34cj2ba2hfeeqnbcodfs6m 174 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 175 1 9 9 CD work_gukk34cj2ba2hfeeqnbcodfs6m 175 2 Sulisalo Sulisalo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 175 3 T T NNP work_gukk34cj2ba2hfeeqnbcodfs6m 175 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 175 5 Klockars Klockars NNP work_gukk34cj2ba2hfeeqnbcodfs6m 175 6 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 175 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 175 8 Mäkitie Mäkitie NNP work_gukk34cj2ba2hfeeqnbcodfs6m 175 9 O o UH work_gukk34cj2ba2hfeeqnbcodfs6m 175 10 et et NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 175 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 175 13 High high JJ work_gukk34cj2ba2hfeeqnbcodfs6m 175 14 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 175 15 resolution resolution NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 16 linkage linkage NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 17 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 175 18 dise- dise- NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 19 quilibrium quilibrium NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 20 mapping mapping NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 175 22 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 175 23 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 24 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 175 25 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 26 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 175 27 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 175 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 176 1 Am be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 176 2 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 176 3 Hum Hum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 176 4 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 176 5 1994 1994 CD work_gukk34cj2ba2hfeeqnbcodfs6m 176 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 176 7 55 55 CD work_gukk34cj2ba2hfeeqnbcodfs6m 176 8 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 176 9 937 937 CD work_gukk34cj2ba2hfeeqnbcodfs6m 176 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 176 11 945 945 CD work_gukk34cj2ba2hfeeqnbcodfs6m 176 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 177 1 10 10 CD work_gukk34cj2ba2hfeeqnbcodfs6m 177 2 McKusick McKusick NNP work_gukk34cj2ba2hfeeqnbcodfs6m 177 3 VA VA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 177 4 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 177 5 Ellis Ellis NNP work_gukk34cj2ba2hfeeqnbcodfs6m 177 6 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 177 7 van van NNP work_gukk34cj2ba2hfeeqnbcodfs6m 177 8 Creveld Creveld NNP work_gukk34cj2ba2hfeeqnbcodfs6m 177 9 syndrome syndrome NN work_gukk34cj2ba2hfeeqnbcodfs6m 177 10 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 177 11 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 177 12 Amish Amish NNP work_gukk34cj2ba2hfeeqnbcodfs6m 177 13 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 178 1 Nat Nat NNP work_gukk34cj2ba2hfeeqnbcodfs6m 178 2 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 178 3 2000 2000 CD work_gukk34cj2ba2hfeeqnbcodfs6m 178 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 178 5 24 24 CD work_gukk34cj2ba2hfeeqnbcodfs6m 178 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 178 7 203 203 CD work_gukk34cj2ba2hfeeqnbcodfs6m 178 8 – – SYM work_gukk34cj2ba2hfeeqnbcodfs6m 178 9 204 204 CD work_gukk34cj2ba2hfeeqnbcodfs6m 178 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 179 1 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 179 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 179 4 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 179 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 8 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 9 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 12 446 446 CD work_gukk34cj2ba2hfeeqnbcodfs6m 179 13 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 14 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 179 16 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 17 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 18 11 11 CD work_gukk34cj2ba2hfeeqnbcodfs6m 179 19 Vakkilainen Vakkilainen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 20 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 21 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 179 22 Kivipensas Kivipensas NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 23 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 24 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 179 25 Kaitila Kaitila NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 26 I I NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 27 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 179 28 de de FW work_gukk34cj2ba2hfeeqnbcodfs6m 179 29 la la NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 30 Chapelle Chapelle NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 31 A A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 32 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 179 33 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 34 M m NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 35 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 179 36 Integrated integrate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 179 37 high high JJ work_gukk34cj2ba2hfeeqnbcodfs6m 179 38 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 179 39 resolution resolution NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 40 BAC BAC NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 41 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 179 42 P1 p1 NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 43 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 179 44 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 179 45 transcript transcript NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 46 map map NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 47 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 179 48 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 179 49 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 179 50 region region NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 51 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 179 52 chromosome chromosome NN work_gukk34cj2ba2hfeeqnbcodfs6m 179 53 9p13 9p13 CD work_gukk34cj2ba2hfeeqnbcodfs6m 179 54 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 180 1 Genomics Genomics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 180 2 1999 1999 CD work_gukk34cj2ba2hfeeqnbcodfs6m 180 3 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 180 4 59 59 CD work_gukk34cj2ba2hfeeqnbcodfs6m 180 5 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 180 6 319 319 CD work_gukk34cj2ba2hfeeqnbcodfs6m 180 7 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 180 8 325 325 CD work_gukk34cj2ba2hfeeqnbcodfs6m 180 9 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 181 1 12 12 CD work_gukk34cj2ba2hfeeqnbcodfs6m 181 2 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 3 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 181 5 van van NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 6 Eenennaam Eenennaam NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 7 H H NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 181 9 Pelin Pelin NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 10 K K NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 11 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 12 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 13 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 181 14 Mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 181 15 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 181 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 181 17 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 18 component component NN work_gukk34cj2ba2hfeeqnbcodfs6m 181 19 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 181 20 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 21 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 181 22 cause cause VB work_gukk34cj2ba2hfeeqnbcodfs6m 181 23 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 181 24 pleiotropic pleiotropic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 181 25 human human JJ work_gukk34cj2ba2hfeeqnbcodfs6m 181 26 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 181 27 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 181 28 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 181 29 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 181 30 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 181 31 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 181 32 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 182 1 Cell Cell NNP work_gukk34cj2ba2hfeeqnbcodfs6m 182 2 2001 2001 CD work_gukk34cj2ba2hfeeqnbcodfs6m 182 3 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 182 4 104 104 CD work_gukk34cj2ba2hfeeqnbcodfs6m 182 5 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 182 6 195 195 CD work_gukk34cj2ba2hfeeqnbcodfs6m 182 7 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 182 8 203 203 CD work_gukk34cj2ba2hfeeqnbcodfs6m 182 9 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 183 1 13 13 CD work_gukk34cj2ba2hfeeqnbcodfs6m 183 2 van van NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 3 Eenennaam Eenennaam NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 4 H H NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 5 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 183 6 Jarrous Jarrous NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 7 N N NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 8 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 183 9 van van NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 10 Venrooij Venrooij NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 11 WJ WJ NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 12 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 183 13 Pruijn Pruijn NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 14 GJ GJ NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 15 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 183 16 Archi- archi- NN work_gukk34cj2ba2hfeeqnbcodfs6m 183 17 tecture tecture NN work_gukk34cj2ba2hfeeqnbcodfs6m 183 18 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 183 19 function function NN work_gukk34cj2ba2hfeeqnbcodfs6m 183 20 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 183 21 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 183 22 human human JJ work_gukk34cj2ba2hfeeqnbcodfs6m 183 23 endonucleases endonuclease NNS work_gukk34cj2ba2hfeeqnbcodfs6m 183 24 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 25 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 26 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 183 27 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 28 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 183 29 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 184 1 IUBMB IUBMB NNP work_gukk34cj2ba2hfeeqnbcodfs6m 184 2 Life life NN work_gukk34cj2ba2hfeeqnbcodfs6m 184 3 2000 2000 CD work_gukk34cj2ba2hfeeqnbcodfs6m 184 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 184 5 49 49 CD work_gukk34cj2ba2hfeeqnbcodfs6m 184 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 184 7 265 265 CD work_gukk34cj2ba2hfeeqnbcodfs6m 184 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 184 9 272 272 CD work_gukk34cj2ba2hfeeqnbcodfs6m 184 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 185 1 14 14 CD work_gukk34cj2ba2hfeeqnbcodfs6m 185 2 Norio Norio NNP work_gukk34cj2ba2hfeeqnbcodfs6m 185 3 R R NNP work_gukk34cj2ba2hfeeqnbcodfs6m 185 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 185 5 Nevanlinna Nevanlinna NNP work_gukk34cj2ba2hfeeqnbcodfs6m 185 6 HR HR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 185 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 185 8 Perheentupa Perheentupa NNP work_gukk34cj2ba2hfeeqnbcodfs6m 185 9 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 185 10 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 185 11 Hereditary hereditary JJ work_gukk34cj2ba2hfeeqnbcodfs6m 185 12 diseases disease NNS work_gukk34cj2ba2hfeeqnbcodfs6m 185 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 185 14 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 185 15 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 185 16 rare rare JJ work_gukk34cj2ba2hfeeqnbcodfs6m 185 17 flora flora NNS work_gukk34cj2ba2hfeeqnbcodfs6m 185 18 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 185 19 rare rare JJ work_gukk34cj2ba2hfeeqnbcodfs6m 185 20 soil soil NN work_gukk34cj2ba2hfeeqnbcodfs6m 185 21 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 186 1 Ann Ann NNP work_gukk34cj2ba2hfeeqnbcodfs6m 186 2 Clin Clin NNP work_gukk34cj2ba2hfeeqnbcodfs6m 186 3 Res Res NNP work_gukk34cj2ba2hfeeqnbcodfs6m 186 4 1973 1973 CD work_gukk34cj2ba2hfeeqnbcodfs6m 186 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 186 6 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 186 7 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 186 8 109 109 CD work_gukk34cj2ba2hfeeqnbcodfs6m 186 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 186 10 141 141 CD work_gukk34cj2ba2hfeeqnbcodfs6m 186 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 187 1 15 15 CD work_gukk34cj2ba2hfeeqnbcodfs6m 187 2 Nevanlinna Nevanlinna NNP work_gukk34cj2ba2hfeeqnbcodfs6m 187 3 HR hr NN work_gukk34cj2ba2hfeeqnbcodfs6m 187 4 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 187 5 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 187 6 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 187 7 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 187 8 structure structure NN work_gukk34cj2ba2hfeeqnbcodfs6m 187 9 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 188 1 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 188 2 genetic genetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 188 3 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 188 4 genealogical genealogical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 188 5 study study NN work_gukk34cj2ba2hfeeqnbcodfs6m 188 6 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 189 1 Hereditas Hereditas NNP work_gukk34cj2ba2hfeeqnbcodfs6m 189 2 1972 1972 CD work_gukk34cj2ba2hfeeqnbcodfs6m 189 3 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 189 4 71 71 CD work_gukk34cj2ba2hfeeqnbcodfs6m 189 5 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 189 6 195 195 CD work_gukk34cj2ba2hfeeqnbcodfs6m 189 7 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 189 8 236 236 CD work_gukk34cj2ba2hfeeqnbcodfs6m 189 9 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 190 1 16 16 CD work_gukk34cj2ba2hfeeqnbcodfs6m 190 2 de de NNP work_gukk34cj2ba2hfeeqnbcodfs6m 190 3 la la NNP work_gukk34cj2ba2hfeeqnbcodfs6m 190 4 Chapelle Chapelle NNP work_gukk34cj2ba2hfeeqnbcodfs6m 190 5 A A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 190 6 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 190 7 Disease Disease NNP work_gukk34cj2ba2hfeeqnbcodfs6m 190 8 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 190 9 mapping mapping NN work_gukk34cj2ba2hfeeqnbcodfs6m 190 10 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 190 11 isolated isolate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 190 12 human human JJ work_gukk34cj2ba2hfeeqnbcodfs6m 190 13 popu- popu- JJ work_gukk34cj2ba2hfeeqnbcodfs6m 190 14 lations lation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 190 15 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 190 16 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 190 17 example example NN work_gukk34cj2ba2hfeeqnbcodfs6m 190 18 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 190 19 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 190 20 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 191 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 191 2 Med Med NNP work_gukk34cj2ba2hfeeqnbcodfs6m 191 3 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 191 4 1993 1993 CD work_gukk34cj2ba2hfeeqnbcodfs6m 191 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 191 6 30 30 CD work_gukk34cj2ba2hfeeqnbcodfs6m 191 7 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 191 8 857 857 CD work_gukk34cj2ba2hfeeqnbcodfs6m 191 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 191 10 865 865 CD work_gukk34cj2ba2hfeeqnbcodfs6m 191 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 192 1 17 17 CD work_gukk34cj2ba2hfeeqnbcodfs6m 192 2 de de NNP work_gukk34cj2ba2hfeeqnbcodfs6m 192 3 la la NNP work_gukk34cj2ba2hfeeqnbcodfs6m 192 4 Chapelle Chapelle NNP work_gukk34cj2ba2hfeeqnbcodfs6m 192 5 A A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 192 6 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 192 7 Wright Wright NNP work_gukk34cj2ba2hfeeqnbcodfs6m 192 8 F F NNP work_gukk34cj2ba2hfeeqnbcodfs6m 192 9 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 192 10 Linkage linkage VB work_gukk34cj2ba2hfeeqnbcodfs6m 192 11 disequilibrium disequilibrium NN work_gukk34cj2ba2hfeeqnbcodfs6m 192 12 mapping mapping NN work_gukk34cj2ba2hfeeqnbcodfs6m 192 13 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 192 14 isolated isolated JJ work_gukk34cj2ba2hfeeqnbcodfs6m 192 15 populations population NNS work_gukk34cj2ba2hfeeqnbcodfs6m 192 16 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 192 17 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 192 18 example example NN work_gukk34cj2ba2hfeeqnbcodfs6m 192 19 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 192 20 Finland Finland NNP work_gukk34cj2ba2hfeeqnbcodfs6m 192 21 revisited revisit VBD work_gukk34cj2ba2hfeeqnbcodfs6m 192 22 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 193 1 Proc Proc NNP work_gukk34cj2ba2hfeeqnbcodfs6m 193 2 Natl Natl NNP work_gukk34cj2ba2hfeeqnbcodfs6m 193 3 Acad Acad NNP work_gukk34cj2ba2hfeeqnbcodfs6m 193 4 Sci Sci NNP work_gukk34cj2ba2hfeeqnbcodfs6m 193 5 1998 1998 CD work_gukk34cj2ba2hfeeqnbcodfs6m 193 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 193 7 95 95 CD work_gukk34cj2ba2hfeeqnbcodfs6m 193 8 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 193 9 12416 12416 CD work_gukk34cj2ba2hfeeqnbcodfs6m 193 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 193 11 12423 12423 CD work_gukk34cj2ba2hfeeqnbcodfs6m 193 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 194 1 18 18 CD work_gukk34cj2ba2hfeeqnbcodfs6m 194 2 Lahiri Lahiri NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 3 DK DK NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 194 5 Bye Bye NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 6 S S NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 194 8 Nürnberger Nürnberger NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 9 Jr Jr NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 10 JI JI NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 11 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 194 12 Hodes Hodes NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 13 ME ME NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 194 15 Crisp Crisp NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 16 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 194 17 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 194 18 A a DT work_gukk34cj2ba2hfeeqnbcodfs6m 194 19 non- non- RB work_gukk34cj2ba2hfeeqnbcodfs6m 194 20 organic organic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 194 21 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 194 22 non non JJ work_gukk34cj2ba2hfeeqnbcodfs6m 194 23 - - JJ work_gukk34cj2ba2hfeeqnbcodfs6m 194 24 enzymatic enzymatic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 194 25 extraction extraction NN work_gukk34cj2ba2hfeeqnbcodfs6m 194 26 method method NN work_gukk34cj2ba2hfeeqnbcodfs6m 194 27 gives give VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 194 28 higher high JJR work_gukk34cj2ba2hfeeqnbcodfs6m 194 29 yields yield NNS work_gukk34cj2ba2hfeeqnbcodfs6m 194 30 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 194 31 genomic genomic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 194 32 DNA dna NN work_gukk34cj2ba2hfeeqnbcodfs6m 194 33 from from IN work_gukk34cj2ba2hfeeqnbcodfs6m 194 34 whole whole JJ work_gukk34cj2ba2hfeeqnbcodfs6m 194 35 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 194 36 blood blood NN work_gukk34cj2ba2hfeeqnbcodfs6m 194 37 samples sample NNS work_gukk34cj2ba2hfeeqnbcodfs6m 194 38 than than IN work_gukk34cj2ba2hfeeqnbcodfs6m 194 39 do do VBP work_gukk34cj2ba2hfeeqnbcodfs6m 194 40 nine nine CD work_gukk34cj2ba2hfeeqnbcodfs6m 194 41 other other JJ work_gukk34cj2ba2hfeeqnbcodfs6m 194 42 methods method NNS work_gukk34cj2ba2hfeeqnbcodfs6m 194 43 tested test VBN work_gukk34cj2ba2hfeeqnbcodfs6m 194 44 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 195 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 195 2 Biochem Biochem NNP work_gukk34cj2ba2hfeeqnbcodfs6m 195 3 Biophys Biophys NNP work_gukk34cj2ba2hfeeqnbcodfs6m 195 4 Methods Methods NNP work_gukk34cj2ba2hfeeqnbcodfs6m 195 5 1992 1992 CD work_gukk34cj2ba2hfeeqnbcodfs6m 195 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 195 7 25 25 CD work_gukk34cj2ba2hfeeqnbcodfs6m 195 8 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 195 9 193 193 CD work_gukk34cj2ba2hfeeqnbcodfs6m 195 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 195 11 205 205 CD work_gukk34cj2ba2hfeeqnbcodfs6m 195 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 196 1 19 19 CD work_gukk34cj2ba2hfeeqnbcodfs6m 196 2 Pelin Pelin NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 3 K K NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 196 5 Hilpelä Hilpelä NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 6 P p NN work_gukk34cj2ba2hfeeqnbcodfs6m 196 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 196 8 Donner Donner NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 9 K K NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 10 et et FW work_gukk34cj2ba2hfeeqnbcodfs6m 196 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 196 13 Mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 196 14 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 196 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 196 16 nebulin nebulin NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 17 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 196 18 associated associate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 196 19 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 196 20 autosomal autosomal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 196 21 recessive recessive JJ work_gukk34cj2ba2hfeeqnbcodfs6m 196 22 nemaline nemaline NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 23 myopathy myopathy NNP work_gukk34cj2ba2hfeeqnbcodfs6m 196 24 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 197 1 Proc Proc NNP work_gukk34cj2ba2hfeeqnbcodfs6m 197 2 Natl Natl NNP work_gukk34cj2ba2hfeeqnbcodfs6m 197 3 Acad Acad NNP work_gukk34cj2ba2hfeeqnbcodfs6m 197 4 Sci Sci NNP work_gukk34cj2ba2hfeeqnbcodfs6m 197 5 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 197 6 1999 1999 CD work_gukk34cj2ba2hfeeqnbcodfs6m 197 7 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 197 8 96 96 CD work_gukk34cj2ba2hfeeqnbcodfs6m 197 9 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 197 10 2305 2305 CD work_gukk34cj2ba2hfeeqnbcodfs6m 197 11 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 197 12 2310 2310 CD work_gukk34cj2ba2hfeeqnbcodfs6m 197 13 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 198 1 20 20 CD work_gukk34cj2ba2hfeeqnbcodfs6m 198 2 Sulisalo Sulisalo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 198 3 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 198 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 198 5 Mäkitie mäkitie NN work_gukk34cj2ba2hfeeqnbcodfs6m 198 6 O o UH work_gukk34cj2ba2hfeeqnbcodfs6m 198 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 198 8 Sistonen Sistonen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 198 9 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 198 10 et et NN work_gukk34cj2ba2hfeeqnbcodfs6m 198 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 198 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 198 13 Uniparental uniparental JJ work_gukk34cj2ba2hfeeqnbcodfs6m 198 14 disomy disomy NN work_gukk34cj2ba2hfeeqnbcodfs6m 198 15 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 198 16 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 198 17 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 198 18 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 198 19 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 198 20 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 199 1 Eur Eur NNP work_gukk34cj2ba2hfeeqnbcodfs6m 199 2 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 199 3 Hum Hum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 199 4 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 199 5 1997 1997 CD work_gukk34cj2ba2hfeeqnbcodfs6m 199 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 199 7 5 5 CD work_gukk34cj2ba2hfeeqnbcodfs6m 199 8 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 199 9 35 35 CD work_gukk34cj2ba2hfeeqnbcodfs6m 199 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 199 11 42 42 CD work_gukk34cj2ba2hfeeqnbcodfs6m 199 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 200 1 21 21 CD work_gukk34cj2ba2hfeeqnbcodfs6m 200 2 Rannala Rannala NNP work_gukk34cj2ba2hfeeqnbcodfs6m 200 3 B B NNP work_gukk34cj2ba2hfeeqnbcodfs6m 200 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 200 5 Slatkin Slatkin NNP work_gukk34cj2ba2hfeeqnbcodfs6m 200 6 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 200 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 200 8 Likelihood likelihood NN work_gukk34cj2ba2hfeeqnbcodfs6m 200 9 analysis analysis NN work_gukk34cj2ba2hfeeqnbcodfs6m 200 10 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 200 11 disequilibrium disequilibrium NN work_gukk34cj2ba2hfeeqnbcodfs6m 200 12 mapping mapping NN work_gukk34cj2ba2hfeeqnbcodfs6m 200 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 200 14 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 200 15 related related JJ work_gukk34cj2ba2hfeeqnbcodfs6m 200 16 problems problem NNS work_gukk34cj2ba2hfeeqnbcodfs6m 200 17 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 201 1 Am be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 201 2 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 201 3 Hum Hum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 201 4 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 201 5 1998 1998 CD work_gukk34cj2ba2hfeeqnbcodfs6m 201 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 201 7 62 62 CD work_gukk34cj2ba2hfeeqnbcodfs6m 201 8 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 201 9 459 459 CD work_gukk34cj2ba2hfeeqnbcodfs6m 201 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 201 11 473 473 CD work_gukk34cj2ba2hfeeqnbcodfs6m 201 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 202 1 22 22 CD work_gukk34cj2ba2hfeeqnbcodfs6m 202 2 Risch Risch NNP work_gukk34cj2ba2hfeeqnbcodfs6m 202 3 N N NNP work_gukk34cj2ba2hfeeqnbcodfs6m 202 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 202 5 Teng Teng NNP work_gukk34cj2ba2hfeeqnbcodfs6m 202 6 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 202 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 202 8 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 202 9 relative relative JJ work_gukk34cj2ba2hfeeqnbcodfs6m 202 10 power power NN work_gukk34cj2ba2hfeeqnbcodfs6m 202 11 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 202 12 family family NN work_gukk34cj2ba2hfeeqnbcodfs6m 202 13 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 202 14 based base VBN work_gukk34cj2ba2hfeeqnbcodfs6m 202 15 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 202 16 case- case- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 202 17 control control NN work_gukk34cj2ba2hfeeqnbcodfs6m 202 18 designs design NNS work_gukk34cj2ba2hfeeqnbcodfs6m 202 19 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 202 20 linkage linkage NN work_gukk34cj2ba2hfeeqnbcodfs6m 202 21 disequilibrium disequilibrium NN work_gukk34cj2ba2hfeeqnbcodfs6m 202 22 studies study NNS work_gukk34cj2ba2hfeeqnbcodfs6m 202 23 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 202 24 complex complex JJ work_gukk34cj2ba2hfeeqnbcodfs6m 202 25 human human JJ work_gukk34cj2ba2hfeeqnbcodfs6m 202 26 diseases disease NNS work_gukk34cj2ba2hfeeqnbcodfs6m 202 27 I. I. NNP work_gukk34cj2ba2hfeeqnbcodfs6m 202 28 DNA DNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 202 29 pooling pooling NN work_gukk34cj2ba2hfeeqnbcodfs6m 202 30 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 203 1 Genome Genome NNP work_gukk34cj2ba2hfeeqnbcodfs6m 203 2 Res Res NNP work_gukk34cj2ba2hfeeqnbcodfs6m 203 3 1998 1998 CD work_gukk34cj2ba2hfeeqnbcodfs6m 203 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 203 5 8 8 CD work_gukk34cj2ba2hfeeqnbcodfs6m 203 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 203 7 1273 1273 CD work_gukk34cj2ba2hfeeqnbcodfs6m 203 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 203 9 1288 1288 CD work_gukk34cj2ba2hfeeqnbcodfs6m 203 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 204 1 23 23 CD work_gukk34cj2ba2hfeeqnbcodfs6m 204 2 Labuda Labuda NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 3 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 204 5 Labuda Labuda NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 6 D D NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 204 8 Korab Korab NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 9 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 204 10 Laskowska Laskowska NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 11 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 12 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 13 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 204 14 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 204 15 Linkage linkage VB work_gukk34cj2ba2hfeeqnbcodfs6m 204 16 disequili- disequili- FW work_gukk34cj2ba2hfeeqnbcodfs6m 204 17 brium brium NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 18 analysis analysis NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 19 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 204 20 young young JJ work_gukk34cj2ba2hfeeqnbcodfs6m 204 21 populations population NNS work_gukk34cj2ba2hfeeqnbcodfs6m 204 22 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 204 23 pseudo pseudo NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 24 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 204 25 vitamin vitamin NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 26 D- d- NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 27 deficiency deficiency NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 28 rickets ricket NNS work_gukk34cj2ba2hfeeqnbcodfs6m 204 29 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 204 30 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 204 31 founder founder NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 32 effect effect NN work_gukk34cj2ba2hfeeqnbcodfs6m 204 33 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 204 34 French french JJ work_gukk34cj2ba2hfeeqnbcodfs6m 204 35 Canadians Canadians NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 204 36 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 205 1 Am be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 205 2 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 205 3 Hum Hum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 205 4 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 205 5 1996 1996 CD work_gukk34cj2ba2hfeeqnbcodfs6m 205 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 205 7 59 59 CD work_gukk34cj2ba2hfeeqnbcodfs6m 205 8 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 205 9 633 633 CD work_gukk34cj2ba2hfeeqnbcodfs6m 205 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 205 11 643 643 CD work_gukk34cj2ba2hfeeqnbcodfs6m 205 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 206 1 24 24 CD work_gukk34cj2ba2hfeeqnbcodfs6m 206 2 Schmitt Schmitt NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 3 ME ME NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 206 5 Bennett Bennett NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 6 JL JL NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 206 8 Dairaghi Dairaghi NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 9 DJ DJ NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 206 11 Clayton Clayton NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 12 DA DA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 13 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 206 14 Secondary secondary JJ work_gukk34cj2ba2hfeeqnbcodfs6m 206 15 structure structure NN work_gukk34cj2ba2hfeeqnbcodfs6m 206 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 206 17 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 18 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 19 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 206 20 as as IN work_gukk34cj2ba2hfeeqnbcodfs6m 206 21 predicted predict VBN work_gukk34cj2ba2hfeeqnbcodfs6m 206 22 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 206 23 phylogenetic phylogenetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 206 24 comparison comparison NN work_gukk34cj2ba2hfeeqnbcodfs6m 206 25 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 207 1 FASEB FASEB NNP work_gukk34cj2ba2hfeeqnbcodfs6m 207 2 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 207 3 1993 1993 CD work_gukk34cj2ba2hfeeqnbcodfs6m 207 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 207 5 7 7 CD work_gukk34cj2ba2hfeeqnbcodfs6m 207 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 207 7 208 208 CD work_gukk34cj2ba2hfeeqnbcodfs6m 207 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 207 9 213 213 CD work_gukk34cj2ba2hfeeqnbcodfs6m 207 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 208 1 25 25 CD work_gukk34cj2ba2hfeeqnbcodfs6m 208 2 Sbisà Sbisà NNS work_gukk34cj2ba2hfeeqnbcodfs6m 208 3 E E NNS work_gukk34cj2ba2hfeeqnbcodfs6m 208 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 208 5 Pesole Pesole NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 6 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 208 8 Tullo Tullo NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 9 A A NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 208 11 Saccone Saccone NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 12 C C NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 13 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 208 14 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 208 15 evolution evolution NN work_gukk34cj2ba2hfeeqnbcodfs6m 208 16 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 208 17 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 208 18 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 19 P- P- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 20 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 208 21 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 22 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 208 23 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 208 24 associated associate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 208 25 RNAs rna NNS work_gukk34cj2ba2hfeeqnbcodfs6m 208 26 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 208 27 phylogenetic phylogenetic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 208 28 analysis analysis NN work_gukk34cj2ba2hfeeqnbcodfs6m 208 29 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 208 30 nucleotide nucleotide JJ work_gukk34cj2ba2hfeeqnbcodfs6m 208 31 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 208 32 rate rate NN work_gukk34cj2ba2hfeeqnbcodfs6m 208 33 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 209 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 209 2 Mol Mol NNP work_gukk34cj2ba2hfeeqnbcodfs6m 209 3 Evol Evol NNP work_gukk34cj2ba2hfeeqnbcodfs6m 209 4 1996 1996 CD work_gukk34cj2ba2hfeeqnbcodfs6m 209 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 209 6 43 43 CD work_gukk34cj2ba2hfeeqnbcodfs6m 209 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 209 8 46 46 CD work_gukk34cj2ba2hfeeqnbcodfs6m 209 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 209 10 57 57 CD work_gukk34cj2ba2hfeeqnbcodfs6m 209 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 210 1 26 26 CD work_gukk34cj2ba2hfeeqnbcodfs6m 210 2 Tremblay Tremblay NNP work_gukk34cj2ba2hfeeqnbcodfs6m 210 3 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 210 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 210 5 Vézina Vézina NNP work_gukk34cj2ba2hfeeqnbcodfs6m 210 6 H h NN work_gukk34cj2ba2hfeeqnbcodfs6m 210 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 210 8 New new JJ work_gukk34cj2ba2hfeeqnbcodfs6m 210 9 estimates estimate NNS work_gukk34cj2ba2hfeeqnbcodfs6m 210 10 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 210 11 intergenerational intergenerational JJ work_gukk34cj2ba2hfeeqnbcodfs6m 210 12 time time NN work_gukk34cj2ba2hfeeqnbcodfs6m 210 13 intervals interval NNS work_gukk34cj2ba2hfeeqnbcodfs6m 210 14 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 210 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 210 16 calculation calculation NN work_gukk34cj2ba2hfeeqnbcodfs6m 210 17 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 210 18 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 210 19 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 210 20 origins origin NNS work_gukk34cj2ba2hfeeqnbcodfs6m 210 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 210 22 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 210 23 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 211 1 Am be VBP work_gukk34cj2ba2hfeeqnbcodfs6m 211 2 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 211 3 Hum Hum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 211 4 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 211 5 2000 2000 CD work_gukk34cj2ba2hfeeqnbcodfs6m 211 6 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 211 7 66 66 CD work_gukk34cj2ba2hfeeqnbcodfs6m 211 8 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 211 9 651 651 CD work_gukk34cj2ba2hfeeqnbcodfs6m 211 10 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 211 11 658 658 CD work_gukk34cj2ba2hfeeqnbcodfs6m 211 12 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 212 1 27 27 CD work_gukk34cj2ba2hfeeqnbcodfs6m 212 2 Jacobsen Jacobsen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 3 MR MR NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 212 5 Cao Cao NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 6 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 7 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 212 8 G G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 9 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 212 10 Wang Wang NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 11 Y Y NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 12 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 212 13 L L NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 14 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 212 15 Pedersen Pedersen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 16 T t NN work_gukk34cj2ba2hfeeqnbcodfs6m 212 17 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 212 18 Dynamic dynamic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 212 19 localiza- localiza- NN work_gukk34cj2ba2hfeeqnbcodfs6m 212 20 tion tion NN work_gukk34cj2ba2hfeeqnbcodfs6m 212 21 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 212 22 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 23 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 24 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 25 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 212 26 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 212 27 nucleolus nucleolus NN work_gukk34cj2ba2hfeeqnbcodfs6m 212 28 observed observe VBN work_gukk34cj2ba2hfeeqnbcodfs6m 212 29 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 212 30 fluorescent fluorescent NN work_gukk34cj2ba2hfeeqnbcodfs6m 212 31 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 212 32 cytochemistry cytochemistry NN work_gukk34cj2ba2hfeeqnbcodfs6m 212 33 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 212 34 living live VBG work_gukk34cj2ba2hfeeqnbcodfs6m 212 35 cells cell NNS work_gukk34cj2ba2hfeeqnbcodfs6m 212 36 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 213 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 213 2 Cell Cell NNP work_gukk34cj2ba2hfeeqnbcodfs6m 213 3 Biol Biol NNP work_gukk34cj2ba2hfeeqnbcodfs6m 213 4 1995 1995 CD work_gukk34cj2ba2hfeeqnbcodfs6m 213 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 213 6 131 131 CD work_gukk34cj2ba2hfeeqnbcodfs6m 213 7 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 213 8 1649 1649 CD work_gukk34cj2ba2hfeeqnbcodfs6m 213 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 213 10 1658 1658 CD work_gukk34cj2ba2hfeeqnbcodfs6m 213 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 214 1 28 28 CD work_gukk34cj2ba2hfeeqnbcodfs6m 214 2 Schmitt Schmitt NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 3 ME ME NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 214 5 Clayton Clayton NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 6 DA DA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 7 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 214 8 Yeast yeast NN work_gukk34cj2ba2hfeeqnbcodfs6m 214 9 site site NN work_gukk34cj2ba2hfeeqnbcodfs6m 214 10 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 214 11 specific specific JJ work_gukk34cj2ba2hfeeqnbcodfs6m 214 12 ribonucleoprotein ribonucleoprotein NN work_gukk34cj2ba2hfeeqnbcodfs6m 214 13 endoribonuclease endoribonuclease NN work_gukk34cj2ba2hfeeqnbcodfs6m 214 14 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 15 contains contain VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 214 16 an an DT work_gukk34cj2ba2hfeeqnbcodfs6m 214 17 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 18 component component NN work_gukk34cj2ba2hfeeqnbcodfs6m 214 19 homolo- homolo- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 20 gous gous NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 21 to to IN work_gukk34cj2ba2hfeeqnbcodfs6m 214 22 mammalian mammalian NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 23 RNase RNase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 24 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 25 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 214 26 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 214 27 essential essential JJ work_gukk34cj2ba2hfeeqnbcodfs6m 214 28 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 214 29 cell cell NN work_gukk34cj2ba2hfeeqnbcodfs6m 214 30 viability viability NN work_gukk34cj2ba2hfeeqnbcodfs6m 214 31 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 215 1 Genes Genes NNP work_gukk34cj2ba2hfeeqnbcodfs6m 215 2 Dev Dev NNP work_gukk34cj2ba2hfeeqnbcodfs6m 215 3 1992 1992 CD work_gukk34cj2ba2hfeeqnbcodfs6m 215 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 215 5 6 6 CD work_gukk34cj2ba2hfeeqnbcodfs6m 215 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 215 7 1975 1975 CD work_gukk34cj2ba2hfeeqnbcodfs6m 215 8 – – SYM work_gukk34cj2ba2hfeeqnbcodfs6m 215 9 1985 1985 CD work_gukk34cj2ba2hfeeqnbcodfs6m 215 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 216 1 29 29 CD work_gukk34cj2ba2hfeeqnbcodfs6m 216 2 Li Li NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 3 K K NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 216 5 Smagula Smagula NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 6 CS CS NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 216 8 Parsons Parsons NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 9 WJ WJ NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 216 13 Subcellular subcellular JJ work_gukk34cj2ba2hfeeqnbcodfs6m 216 14 partitioning partitioning NN work_gukk34cj2ba2hfeeqnbcodfs6m 216 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 216 16 MRP MRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 17 RNA RNA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 216 18 assessed assess VBN work_gukk34cj2ba2hfeeqnbcodfs6m 216 19 by by IN work_gukk34cj2ba2hfeeqnbcodfs6m 216 20 ultrastructural ultrastructural JJ work_gukk34cj2ba2hfeeqnbcodfs6m 216 21 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 216 22 biochemical biochemical JJ work_gukk34cj2ba2hfeeqnbcodfs6m 216 23 analysis analysis NN work_gukk34cj2ba2hfeeqnbcodfs6m 216 24 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 217 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 217 2 Cell Cell NNP work_gukk34cj2ba2hfeeqnbcodfs6m 217 3 Biol Biol NNP work_gukk34cj2ba2hfeeqnbcodfs6m 217 4 1994 1994 CD work_gukk34cj2ba2hfeeqnbcodfs6m 217 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 217 6 124 124 CD work_gukk34cj2ba2hfeeqnbcodfs6m 217 7 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 217 8 871 871 CD work_gukk34cj2ba2hfeeqnbcodfs6m 217 9 – – SYM work_gukk34cj2ba2hfeeqnbcodfs6m 217 10 882 882 CD work_gukk34cj2ba2hfeeqnbcodfs6m 217 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 218 1 30 30 CD work_gukk34cj2ba2hfeeqnbcodfs6m 218 2 Ikonen Ikonen NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 3 E E NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 218 5 Aula Aula NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 6 P P NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 218 8 Grön Grön VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 218 9 K K NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 218 13 Spectrum Spectrum NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 14 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 218 15 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 218 16 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 218 17 aspartyl- aspartyl- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 18 glucosaminuria glucosaminuria NNP work_gukk34cj2ba2hfeeqnbcodfs6m 218 19 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 219 1 Proc Proc NNP work_gukk34cj2ba2hfeeqnbcodfs6m 219 2 Nat Nat NNP work_gukk34cj2ba2hfeeqnbcodfs6m 219 3 Acad Acad NNP work_gukk34cj2ba2hfeeqnbcodfs6m 219 4 Sci Sci NNP work_gukk34cj2ba2hfeeqnbcodfs6m 219 5 USA USA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 219 6 1991 1991 CD work_gukk34cj2ba2hfeeqnbcodfs6m 219 7 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 219 8 88 88 CD work_gukk34cj2ba2hfeeqnbcodfs6m 219 9 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 219 10 11222 11222 CD work_gukk34cj2ba2hfeeqnbcodfs6m 219 11 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 219 12 11226 11226 CD work_gukk34cj2ba2hfeeqnbcodfs6m 219 13 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 220 1 31 31 CD work_gukk34cj2ba2hfeeqnbcodfs6m 220 2 Vesa Vesa NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 3 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 220 5 Hellsten Hellsten NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 6 E E NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 220 8 Verkruyse Verkruyse NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 9 LA LA NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 220 13 Mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 220 14 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 220 15 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 220 16 palmitoyl palmitoyl NN work_gukk34cj2ba2hfeeqnbcodfs6m 220 17 protein protein NN work_gukk34cj2ba2hfeeqnbcodfs6m 220 18 thioesterase thioesterase NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 19 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 220 20 causing cause VBG work_gukk34cj2ba2hfeeqnbcodfs6m 220 21 infantile infantile JJ work_gukk34cj2ba2hfeeqnbcodfs6m 220 22 neuronal neuronal JJ work_gukk34cj2ba2hfeeqnbcodfs6m 220 23 ceroid ceroid NN work_gukk34cj2ba2hfeeqnbcodfs6m 220 24 lipo- lipo- NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 25 fuscinosis fuscinosis NNP work_gukk34cj2ba2hfeeqnbcodfs6m 220 26 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 221 1 Nature nature NN work_gukk34cj2ba2hfeeqnbcodfs6m 221 2 1995 1995 CD work_gukk34cj2ba2hfeeqnbcodfs6m 221 3 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 221 4 376 376 CD work_gukk34cj2ba2hfeeqnbcodfs6m 221 5 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 221 6 584 584 CD work_gukk34cj2ba2hfeeqnbcodfs6m 221 7 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 221 8 587 587 CD work_gukk34cj2ba2hfeeqnbcodfs6m 221 9 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 222 1 32 32 CD work_gukk34cj2ba2hfeeqnbcodfs6m 222 2 Järvelä Järvelä NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 3 I I NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 222 5 Mitchison Mitchison NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 6 HM HM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 222 8 Munroe Munroe NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 9 PB PB NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 10 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 222 11 O’Rawe o’rawe NN work_gukk34cj2ba2hfeeqnbcodfs6m 222 12 AM AM NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 13 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 222 14 Mole Mole NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 15 SE SE NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 16 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 222 17 Syvä- syvä- CD work_gukk34cj2ba2hfeeqnbcodfs6m 222 18 nen nen NN work_gukk34cj2ba2hfeeqnbcodfs6m 222 19 AC AC NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 20 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 222 21 Rapid rapid JJ work_gukk34cj2ba2hfeeqnbcodfs6m 222 22 diagnostic diagnostic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 222 23 test test NN work_gukk34cj2ba2hfeeqnbcodfs6m 222 24 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 222 25 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 222 26 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 222 27 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 222 28 underlying underlie VBG work_gukk34cj2ba2hfeeqnbcodfs6m 222 29 Batten Batten NNP work_gukk34cj2ba2hfeeqnbcodfs6m 222 30 disease disease NN work_gukk34cj2ba2hfeeqnbcodfs6m 222 31 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 223 1 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 223 2 Med Med NNP work_gukk34cj2ba2hfeeqnbcodfs6m 223 3 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 223 4 1996 1996 CD work_gukk34cj2ba2hfeeqnbcodfs6m 223 5 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 223 6 33 33 CD work_gukk34cj2ba2hfeeqnbcodfs6m 223 7 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 223 8 1041 1041 CD work_gukk34cj2ba2hfeeqnbcodfs6m 223 9 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 223 10 1042 1042 CD work_gukk34cj2ba2hfeeqnbcodfs6m 223 11 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 224 1 33 33 CD work_gukk34cj2ba2hfeeqnbcodfs6m 224 2 Kestilä kestilä NN work_gukk34cj2ba2hfeeqnbcodfs6m 224 3 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 224 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 224 5 Lenkkeri Lenkkeri NNP work_gukk34cj2ba2hfeeqnbcodfs6m 224 6 U U NNP work_gukk34cj2ba2hfeeqnbcodfs6m 224 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 224 8 Männikkö Männikkö NNP work_gukk34cj2ba2hfeeqnbcodfs6m 224 9 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 224 10 et et NN work_gukk34cj2ba2hfeeqnbcodfs6m 224 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 224 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 224 13 Positionally positionally RB work_gukk34cj2ba2hfeeqnbcodfs6m 224 14 cloned clone VBN work_gukk34cj2ba2hfeeqnbcodfs6m 224 15 gene gene NN work_gukk34cj2ba2hfeeqnbcodfs6m 224 16 for for IN work_gukk34cj2ba2hfeeqnbcodfs6m 224 17 a a DT work_gukk34cj2ba2hfeeqnbcodfs6m 224 18 novel novel JJ work_gukk34cj2ba2hfeeqnbcodfs6m 224 19 glomerular glomerular JJ work_gukk34cj2ba2hfeeqnbcodfs6m 224 20 protein protein NN work_gukk34cj2ba2hfeeqnbcodfs6m 224 21 nephrin nephrin NN work_gukk34cj2ba2hfeeqnbcodfs6m 224 22 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 224 23 mutated mutate VBN work_gukk34cj2ba2hfeeqnbcodfs6m 224 24 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 224 25 congenital congenital JJ work_gukk34cj2ba2hfeeqnbcodfs6m 224 26 nephrotic nephrotic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 224 27 syndrome syndrome NN work_gukk34cj2ba2hfeeqnbcodfs6m 224 28 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 225 1 Mol Mol NNP work_gukk34cj2ba2hfeeqnbcodfs6m 225 2 Cell Cell NNP work_gukk34cj2ba2hfeeqnbcodfs6m 225 3 1998 1998 CD work_gukk34cj2ba2hfeeqnbcodfs6m 225 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 225 5 1 1 CD work_gukk34cj2ba2hfeeqnbcodfs6m 225 6 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 225 7 575 575 CD work_gukk34cj2ba2hfeeqnbcodfs6m 225 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 225 9 582 582 CD work_gukk34cj2ba2hfeeqnbcodfs6m 225 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 226 1 34 34 CD work_gukk34cj2ba2hfeeqnbcodfs6m 226 2 Virtaneva Virtaneva NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 3 K K NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 4 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 226 5 D’Amato D’Amato NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 6 E E NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 7 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 226 8 Miao Miao NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 9 J J NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 12 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 226 13 Unstable unstable JJ work_gukk34cj2ba2hfeeqnbcodfs6m 226 14 minisatellite minisatellite NN work_gukk34cj2ba2hfeeqnbcodfs6m 226 15 expansion expansion NN work_gukk34cj2ba2hfeeqnbcodfs6m 226 16 causing cause VBG work_gukk34cj2ba2hfeeqnbcodfs6m 226 17 recessively recessively RB work_gukk34cj2ba2hfeeqnbcodfs6m 226 18 inherited inherit VBN work_gukk34cj2ba2hfeeqnbcodfs6m 226 19 myoclonus myoclonus NN work_gukk34cj2ba2hfeeqnbcodfs6m 226 20 epilepsy epilepsy NN work_gukk34cj2ba2hfeeqnbcodfs6m 226 21 , , , work_gukk34cj2ba2hfeeqnbcodfs6m 226 22 EPM1 EPM1 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 226 23 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 227 1 Nat Nat NNP work_gukk34cj2ba2hfeeqnbcodfs6m 227 2 Genet Genet NNP work_gukk34cj2ba2hfeeqnbcodfs6m 227 3 1997 1997 CD work_gukk34cj2ba2hfeeqnbcodfs6m 227 4 ; ; : work_gukk34cj2ba2hfeeqnbcodfs6m 227 5 15 15 CD work_gukk34cj2ba2hfeeqnbcodfs6m 227 6 : : SYM work_gukk34cj2ba2hfeeqnbcodfs6m 227 7 393 393 CD work_gukk34cj2ba2hfeeqnbcodfs6m 227 8 – – : work_gukk34cj2ba2hfeeqnbcodfs6m 227 9 396 396 CD work_gukk34cj2ba2hfeeqnbcodfs6m 227 10 . . . work_gukk34cj2ba2hfeeqnbcodfs6m 228 1 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 2 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 3 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 4 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 5 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 228 6 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 7 hypoplasia hypoplasia NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 8 M M NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 9 Ridanpää Ridanpää NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 10 et et NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 11 al al NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 12 447 447 CD work_gukk34cj2ba2hfeeqnbcodfs6m 228 13 European European NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 14 Journal Journal NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 15 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 16 Human Human NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 17 Genetics Genetics NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 18 Worldwide Worldwide NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 19 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 20 spectrum spectrum NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 21 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 22 cartilage cartilage NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 23 - - HYPH work_gukk34cj2ba2hfeeqnbcodfs6m 228 24 hair hair NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 25 hypoplasia hypoplasia NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 26 : : : work_gukk34cj2ba2hfeeqnbcodfs6m 228 27 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 28 founder founder NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 29 origin origin NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 30 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 31 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 32 major70A→G major70A→G NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 33 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 34 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 35 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 36 untranslated untranslated JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 37 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 38 Introduction Introduction NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 39 Materials Materials NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 228 40 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 228 41 methods method NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 42 Subjects subject NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 43 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 228 44 families family NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 45 Mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 46 detection detection NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 47 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 48 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 49 Analysis Analysis NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 50 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 51 polymorphic polymorphic JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 52 markers marker NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 53 and and CC work_gukk34cj2ba2hfeeqnbcodfs6m 228 54 reconstruction reconstruction NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 55 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 56 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 57 Methods Methods NNPS work_gukk34cj2ba2hfeeqnbcodfs6m 228 58 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 59 computing compute VBG work_gukk34cj2ba2hfeeqnbcodfs6m 228 60 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 61 age age NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 62 of of IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 63 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 64 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 65 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 66 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 67 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 68 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 69 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 70 Results Results NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 71 RMRP RMRP NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 72 mutations mutation NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 73 segregate segregate VBP work_gukk34cj2ba2hfeeqnbcodfs6m 228 74 with with IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 75 specific specific JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 76 haplotypes haplotype NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 77 in in IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 78 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 79 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 80 population population NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 81 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 82 A70 A70 NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 83 G g NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 84 substitution substitution NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 85 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 228 86 the the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 87 most most RBS work_gukk34cj2ba2hfeeqnbcodfs6m 228 88 common common JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 89 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 90 among among IN work_gukk34cj2ba2hfeeqnbcodfs6m 228 91 CHH CHH NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 92 patients patient NNS work_gukk34cj2ba2hfeeqnbcodfs6m 228 93 worldwide worldwide RB work_gukk34cj2ba2hfeeqnbcodfs6m 228 94 The the DT work_gukk34cj2ba2hfeeqnbcodfs6m 228 95 Finnish finnish JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 96 major major JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 97 mutation mutation NN work_gukk34cj2ba2hfeeqnbcodfs6m 228 98 is be VBZ work_gukk34cj2ba2hfeeqnbcodfs6m 228 99 ancient ancient JJ work_gukk34cj2ba2hfeeqnbcodfs6m 228 100 Discussion Discussion NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 101 Acknowledgements Acknowledgements NNP work_gukk34cj2ba2hfeeqnbcodfs6m 228 102 References References NNPS