id sid tid token lemma pos work_fzrpauvhvnexhintldqhzusndm 1 1 Multiomics Multiomics NNPS work_fzrpauvhvnexhintldqhzusndm 1 2 and and CC work_fzrpauvhvnexhintldqhzusndm 1 3 Systems Systems NNPS work_fzrpauvhvnexhintldqhzusndm 1 4 Biology Biology NNP work_fzrpauvhvnexhintldqhzusndm 1 5 Are be VBP work_fzrpauvhvnexhintldqhzusndm 1 6 Needed need VBN work_fzrpauvhvnexhintldqhzusndm 1 7 to to TO work_fzrpauvhvnexhintldqhzusndm 1 8 Unravel unravel VB work_fzrpauvhvnexhintldqhzusndm 1 9 the the DT work_fzrpauvhvnexhintldqhzusndm 1 10 Complex Complex NNP work_fzrpauvhvnexhintldqhzusndm 1 11 Origins Origins NNP work_fzrpauvhvnexhintldqhzusndm 1 12 of of IN work_fzrpauvhvnexhintldqhzusndm 1 13 Chronic Chronic NNP work_fzrpauvhvnexhintldqhzusndm 1 14 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 1 15 challenges challenge VBZ work_fzrpauvhvnexhintldqhzusndm 1 16 Commentary Commentary NNP work_fzrpauvhvnexhintldqhzusndm 1 17 Multiomics Multiomics NNPS work_fzrpauvhvnexhintldqhzusndm 1 18 and and CC work_fzrpauvhvnexhintldqhzusndm 1 19 Systems Systems NNPS work_fzrpauvhvnexhintldqhzusndm 1 20 Biology Biology NNP work_fzrpauvhvnexhintldqhzusndm 1 21 Are be VBP work_fzrpauvhvnexhintldqhzusndm 1 22 Needed need VBN work_fzrpauvhvnexhintldqhzusndm 1 23 to to TO work_fzrpauvhvnexhintldqhzusndm 1 24 Unravel unravel VB work_fzrpauvhvnexhintldqhzusndm 1 25 the the DT work_fzrpauvhvnexhintldqhzusndm 1 26 Complex Complex NNP work_fzrpauvhvnexhintldqhzusndm 1 27 Origins Origins NNP work_fzrpauvhvnexhintldqhzusndm 1 28 of of IN work_fzrpauvhvnexhintldqhzusndm 1 29 Chronic Chronic NNP work_fzrpauvhvnexhintldqhzusndm 1 30 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 1 31 David David NNP work_fzrpauvhvnexhintldqhzusndm 1 32 Martino Martino NNP work_fzrpauvhvnexhintldqhzusndm 1 33 1 1 CD work_fzrpauvhvnexhintldqhzusndm 1 34 , , , work_fzrpauvhvnexhintldqhzusndm 1 35 * * NFP work_fzrpauvhvnexhintldqhzusndm 1 36 , , , work_fzrpauvhvnexhintldqhzusndm 1 37 Rym Rym NNP work_fzrpauvhvnexhintldqhzusndm 1 38 Ben Ben NNP work_fzrpauvhvnexhintldqhzusndm 1 39 - - HYPH work_fzrpauvhvnexhintldqhzusndm 1 40 Othman Othman NNP work_fzrpauvhvnexhintldqhzusndm 1 41 2 2 CD work_fzrpauvhvnexhintldqhzusndm 1 42 , , , work_fzrpauvhvnexhintldqhzusndm 1 43 Danny Danny NNP work_fzrpauvhvnexhintldqhzusndm 1 44 Harbeson Harbeson NNP work_fzrpauvhvnexhintldqhzusndm 1 45 2 2 CD work_fzrpauvhvnexhintldqhzusndm 1 46 and and CC work_fzrpauvhvnexhintldqhzusndm 1 47 Anthony Anthony NNP work_fzrpauvhvnexhintldqhzusndm 1 48 Bosco Bosco NNP work_fzrpauvhvnexhintldqhzusndm 1 49 1 1 CD work_fzrpauvhvnexhintldqhzusndm 1 50 , , , work_fzrpauvhvnexhintldqhzusndm 1 51 * * NFP work_fzrpauvhvnexhintldqhzusndm 1 52 1 1 CD work_fzrpauvhvnexhintldqhzusndm 1 53 Telethon Telethon NNP work_fzrpauvhvnexhintldqhzusndm 1 54 Kids Kids NNPS work_fzrpauvhvnexhintldqhzusndm 1 55 Institute Institute NNP work_fzrpauvhvnexhintldqhzusndm 1 56 ; ; : work_fzrpauvhvnexhintldqhzusndm 1 57 University University NNP work_fzrpauvhvnexhintldqhzusndm 1 58 of of IN work_fzrpauvhvnexhintldqhzusndm 1 59 Western Western NNP work_fzrpauvhvnexhintldqhzusndm 1 60 Australia Australia NNP work_fzrpauvhvnexhintldqhzusndm 1 61 , , , work_fzrpauvhvnexhintldqhzusndm 1 62 Nedlands Nedlands NNP work_fzrpauvhvnexhintldqhzusndm 1 63 , , , work_fzrpauvhvnexhintldqhzusndm 1 64 WA WA NNP work_fzrpauvhvnexhintldqhzusndm 1 65 6009 6009 CD work_fzrpauvhvnexhintldqhzusndm 1 66 , , , work_fzrpauvhvnexhintldqhzusndm 1 67 Australia Australia NNP work_fzrpauvhvnexhintldqhzusndm 1 68 2 2 CD work_fzrpauvhvnexhintldqhzusndm 1 69 Department Department NNP work_fzrpauvhvnexhintldqhzusndm 1 70 of of IN work_fzrpauvhvnexhintldqhzusndm 1 71 Pediatrics Pediatrics NNPS work_fzrpauvhvnexhintldqhzusndm 1 72 , , , work_fzrpauvhvnexhintldqhzusndm 1 73 Division Division NNP work_fzrpauvhvnexhintldqhzusndm 1 74 of of IN work_fzrpauvhvnexhintldqhzusndm 1 75 Infectious Infectious NNP work_fzrpauvhvnexhintldqhzusndm 1 76 Diseases Diseases NNPS work_fzrpauvhvnexhintldqhzusndm 1 77 , , , work_fzrpauvhvnexhintldqhzusndm 1 78 University University NNP work_fzrpauvhvnexhintldqhzusndm 1 79 of of IN work_fzrpauvhvnexhintldqhzusndm 1 80 British British NNP work_fzrpauvhvnexhintldqhzusndm 1 81 Columbia Columbia NNP work_fzrpauvhvnexhintldqhzusndm 1 82 , , , work_fzrpauvhvnexhintldqhzusndm 1 83 Vancouver Vancouver NNP work_fzrpauvhvnexhintldqhzusndm 1 84 , , , work_fzrpauvhvnexhintldqhzusndm 1 85 BC BC NNP work_fzrpauvhvnexhintldqhzusndm 1 86 V5Z V5Z NNP work_fzrpauvhvnexhintldqhzusndm 1 87 1M9 1M9 NNP work_fzrpauvhvnexhintldqhzusndm 1 88 , , , work_fzrpauvhvnexhintldqhzusndm 1 89 Canada Canada NNP work_fzrpauvhvnexhintldqhzusndm 1 90 ; ; : work_fzrpauvhvnexhintldqhzusndm 1 91 rbenothman@bcchr.ubc.ca rbenothman@bcchr.ubc.ca NNP work_fzrpauvhvnexhintldqhzusndm 1 92 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 1 93 R.B.-O. R.B.-O. NNP work_fzrpauvhvnexhintldqhzusndm 2 1 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 2 2 ; ; : work_fzrpauvhvnexhintldqhzusndm 2 3 dannyharbeson@gmail.com dannyharbeson@gmail.com ADD work_fzrpauvhvnexhintldqhzusndm 2 4 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 2 5 D.H. D.H. NNP work_fzrpauvhvnexhintldqhzusndm 2 6 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 2 7 * * NFP work_fzrpauvhvnexhintldqhzusndm 2 8 Correspondence correspondence NN work_fzrpauvhvnexhintldqhzusndm 2 9 : : : work_fzrpauvhvnexhintldqhzusndm 2 10 David.Martino@telethonkids.org.au David.Martino@telethonkids.org.au NNP work_fzrpauvhvnexhintldqhzusndm 2 11 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 2 12 D.M. D.M. NNP work_fzrpauvhvnexhintldqhzusndm 3 1 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 3 2 ; ; : work_fzrpauvhvnexhintldqhzusndm 3 3 Anthony.Bosco@telethonkids.org.au Anthony.Bosco@telethonkids.org.au NNP work_fzrpauvhvnexhintldqhzusndm 3 4 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 3 5 A.B. A.B. NNP work_fzrpauvhvnexhintldqhzusndm 3 6 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 4 1 Received receive VBN work_fzrpauvhvnexhintldqhzusndm 4 2 : : : work_fzrpauvhvnexhintldqhzusndm 4 3 14 14 CD work_fzrpauvhvnexhintldqhzusndm 4 4 December December NNP work_fzrpauvhvnexhintldqhzusndm 4 5 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 4 6 ; ; : work_fzrpauvhvnexhintldqhzusndm 4 7 Accepted Accepted NNP work_fzrpauvhvnexhintldqhzusndm 4 8 : : : work_fzrpauvhvnexhintldqhzusndm 4 9 13 13 CD work_fzrpauvhvnexhintldqhzusndm 4 10 March March NNP work_fzrpauvhvnexhintldqhzusndm 4 11 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 4 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 4 13 Published publish VBN work_fzrpauvhvnexhintldqhzusndm 4 14 : : : work_fzrpauvhvnexhintldqhzusndm 4 15 21 21 CD work_fzrpauvhvnexhintldqhzusndm 4 16 March March NNP work_fzrpauvhvnexhintldqhzusndm 4 17 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 4 18 � � NNS work_fzrpauvhvnexhintldqhzusndm 4 19 � � , work_fzrpauvhvnexhintldqhzusndm 4 20 � � NNS work_fzrpauvhvnexhintldqhzusndm 4 21 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 22 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 23 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 24 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 25 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 26 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 27 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 28 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 29 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 30 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 31 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 32 � � VBZ work_fzrpauvhvnexhintldqhzusndm 4 33 � � JJ work_fzrpauvhvnexhintldqhzusndm 4 34 � � JJ work_fzrpauvhvnexhintldqhzusndm 4 35 Abstract abstract JJ work_fzrpauvhvnexhintldqhzusndm 4 36 : : : work_fzrpauvhvnexhintldqhzusndm 4 37 Modernization modernization NN work_fzrpauvhvnexhintldqhzusndm 4 38 has have VBZ work_fzrpauvhvnexhintldqhzusndm 4 39 now now RB work_fzrpauvhvnexhintldqhzusndm 4 40 been be VBN work_fzrpauvhvnexhintldqhzusndm 4 41 linked link VBN work_fzrpauvhvnexhintldqhzusndm 4 42 to to IN work_fzrpauvhvnexhintldqhzusndm 4 43 poor poor JJ work_fzrpauvhvnexhintldqhzusndm 4 44 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 4 45 experience experience NN work_fzrpauvhvnexhintldqhzusndm 4 46 , , , work_fzrpauvhvnexhintldqhzusndm 4 47 the the DT work_fzrpauvhvnexhintldqhzusndm 4 48 onset onset NN work_fzrpauvhvnexhintldqhzusndm 4 49 of of IN work_fzrpauvhvnexhintldqhzusndm 4 50 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 4 51 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 4 52 and and CC work_fzrpauvhvnexhintldqhzusndm 4 53 rising rise VBG work_fzrpauvhvnexhintldqhzusndm 4 54 rates rate NNS work_fzrpauvhvnexhintldqhzusndm 4 55 of of IN work_fzrpauvhvnexhintldqhzusndm 4 56 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 4 57 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 4 58 in in IN work_fzrpauvhvnexhintldqhzusndm 4 59 many many JJ work_fzrpauvhvnexhintldqhzusndm 4 60 parts part NNS work_fzrpauvhvnexhintldqhzusndm 4 61 of of IN work_fzrpauvhvnexhintldqhzusndm 4 62 the the DT work_fzrpauvhvnexhintldqhzusndm 4 63 world world NN work_fzrpauvhvnexhintldqhzusndm 4 64 . . . work_fzrpauvhvnexhintldqhzusndm 5 1 Research research NN work_fzrpauvhvnexhintldqhzusndm 5 2 across across IN work_fzrpauvhvnexhintldqhzusndm 5 3 the the DT work_fzrpauvhvnexhintldqhzusndm 5 4 epidemiological epidemiological JJ work_fzrpauvhvnexhintldqhzusndm 5 5 , , , work_fzrpauvhvnexhintldqhzusndm 5 6 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 5 7 , , , work_fzrpauvhvnexhintldqhzusndm 5 8 and and CC work_fzrpauvhvnexhintldqhzusndm 5 9 basic basic JJ work_fzrpauvhvnexhintldqhzusndm 5 10 science science NN work_fzrpauvhvnexhintldqhzusndm 5 11 domains domain NNS work_fzrpauvhvnexhintldqhzusndm 5 12 supports support VBZ work_fzrpauvhvnexhintldqhzusndm 5 13 the the DT work_fzrpauvhvnexhintldqhzusndm 5 14 concept concept NN work_fzrpauvhvnexhintldqhzusndm 5 15 that that IN work_fzrpauvhvnexhintldqhzusndm 5 16 poor poor JJ work_fzrpauvhvnexhintldqhzusndm 5 17 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 5 18 experience experience NN work_fzrpauvhvnexhintldqhzusndm 5 19 , , , work_fzrpauvhvnexhintldqhzusndm 5 20 particularly particularly RB work_fzrpauvhvnexhintldqhzusndm 5 21 during during IN work_fzrpauvhvnexhintldqhzusndm 5 22 prenatal prenatal JJ work_fzrpauvhvnexhintldqhzusndm 5 23 life life NN work_fzrpauvhvnexhintldqhzusndm 5 24 , , , work_fzrpauvhvnexhintldqhzusndm 5 25 can can MD work_fzrpauvhvnexhintldqhzusndm 5 26 increase increase VB work_fzrpauvhvnexhintldqhzusndm 5 27 the the DT work_fzrpauvhvnexhintldqhzusndm 5 28 risk risk NN work_fzrpauvhvnexhintldqhzusndm 5 29 of of IN work_fzrpauvhvnexhintldqhzusndm 5 30 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 5 31 disease disease NN work_fzrpauvhvnexhintldqhzusndm 5 32 , , , work_fzrpauvhvnexhintldqhzusndm 5 33 with with IN work_fzrpauvhvnexhintldqhzusndm 5 34 enduring endure VBG work_fzrpauvhvnexhintldqhzusndm 5 35 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 5 36 on on IN work_fzrpauvhvnexhintldqhzusndm 5 37 long long JJ work_fzrpauvhvnexhintldqhzusndm 5 38 - - HYPH work_fzrpauvhvnexhintldqhzusndm 5 39 term term NN work_fzrpauvhvnexhintldqhzusndm 5 40 health health NN work_fzrpauvhvnexhintldqhzusndm 5 41 . . . work_fzrpauvhvnexhintldqhzusndm 6 1 Single single JJ work_fzrpauvhvnexhintldqhzusndm 6 2 ‘ ' `` work_fzrpauvhvnexhintldqhzusndm 6 3 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 6 4 ’ ' '' work_fzrpauvhvnexhintldqhzusndm 6 5 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 6 6 are be VBP work_fzrpauvhvnexhintldqhzusndm 6 7 ill ill RB work_fzrpauvhvnexhintldqhzusndm 6 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 6 9 suited suited JJ work_fzrpauvhvnexhintldqhzusndm 6 10 to to IN work_fzrpauvhvnexhintldqhzusndm 6 11 dealing deal VBG work_fzrpauvhvnexhintldqhzusndm 6 12 with with IN work_fzrpauvhvnexhintldqhzusndm 6 13 the the DT work_fzrpauvhvnexhintldqhzusndm 6 14 level level NN work_fzrpauvhvnexhintldqhzusndm 6 15 of of IN work_fzrpauvhvnexhintldqhzusndm 6 16 complexity complexity NN work_fzrpauvhvnexhintldqhzusndm 6 17 that that WDT work_fzrpauvhvnexhintldqhzusndm 6 18 underpins underpin VBZ work_fzrpauvhvnexhintldqhzusndm 6 19 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 6 20 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 6 21 in in IN work_fzrpauvhvnexhintldqhzusndm 6 22 early early JJ work_fzrpauvhvnexhintldqhzusndm 6 23 life life NN work_fzrpauvhvnexhintldqhzusndm 6 24 . . . work_fzrpauvhvnexhintldqhzusndm 7 1 A a DT work_fzrpauvhvnexhintldqhzusndm 7 2 more more RBR work_fzrpauvhvnexhintldqhzusndm 7 3 comprehensive comprehensive JJ work_fzrpauvhvnexhintldqhzusndm 7 4 systems system NNS work_fzrpauvhvnexhintldqhzusndm 7 5 - - HYPH work_fzrpauvhvnexhintldqhzusndm 7 6 level level NN work_fzrpauvhvnexhintldqhzusndm 7 7 view view NN work_fzrpauvhvnexhintldqhzusndm 7 8 is be VBZ work_fzrpauvhvnexhintldqhzusndm 7 9 afforded afford VBN work_fzrpauvhvnexhintldqhzusndm 7 10 by by IN work_fzrpauvhvnexhintldqhzusndm 7 11 combining combine VBG work_fzrpauvhvnexhintldqhzusndm 7 12 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 7 13 ‘ ' `` work_fzrpauvhvnexhintldqhzusndm 7 14 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 7 15 ’ ' '' work_fzrpauvhvnexhintldqhzusndm 7 16 datasets dataset NNS work_fzrpauvhvnexhintldqhzusndm 7 17 in in IN work_fzrpauvhvnexhintldqhzusndm 7 18 order order NN work_fzrpauvhvnexhintldqhzusndm 7 19 to to TO work_fzrpauvhvnexhintldqhzusndm 7 20 delineate delineate VB work_fzrpauvhvnexhintldqhzusndm 7 21 correlations correlation NNS work_fzrpauvhvnexhintldqhzusndm 7 22 across across IN work_fzrpauvhvnexhintldqhzusndm 7 23 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 7 24 resolutions resolution NNS work_fzrpauvhvnexhintldqhzusndm 7 25 of of IN work_fzrpauvhvnexhintldqhzusndm 7 26 the the DT work_fzrpauvhvnexhintldqhzusndm 7 27 genome genome NN work_fzrpauvhvnexhintldqhzusndm 7 28 , , , work_fzrpauvhvnexhintldqhzusndm 7 29 and and CC work_fzrpauvhvnexhintldqhzusndm 7 30 of of IN work_fzrpauvhvnexhintldqhzusndm 7 31 the the DT work_fzrpauvhvnexhintldqhzusndm 7 32 genomes genome NNS work_fzrpauvhvnexhintldqhzusndm 7 33 of of IN work_fzrpauvhvnexhintldqhzusndm 7 34 the the DT work_fzrpauvhvnexhintldqhzusndm 7 35 microorganisms microorganism NNS work_fzrpauvhvnexhintldqhzusndm 7 36 that that WDT work_fzrpauvhvnexhintldqhzusndm 7 37 inhabit inhabit VBP work_fzrpauvhvnexhintldqhzusndm 7 38 us -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 7 39 . . . work_fzrpauvhvnexhintldqhzusndm 8 1 In in IN work_fzrpauvhvnexhintldqhzusndm 8 2 this this DT work_fzrpauvhvnexhintldqhzusndm 8 3 concept concept NN work_fzrpauvhvnexhintldqhzusndm 8 4 paper paper NN work_fzrpauvhvnexhintldqhzusndm 8 5 , , , work_fzrpauvhvnexhintldqhzusndm 8 6 we -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 8 7 discuss discuss VBP work_fzrpauvhvnexhintldqhzusndm 8 8 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 8 9 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 8 10 to to IN work_fzrpauvhvnexhintldqhzusndm 8 11 studying study VBG work_fzrpauvhvnexhintldqhzusndm 8 12 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 8 13 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 8 14 and and CC work_fzrpauvhvnexhintldqhzusndm 8 15 highlight highlight NN work_fzrpauvhvnexhintldqhzusndm 8 16 some some DT work_fzrpauvhvnexhintldqhzusndm 8 17 of of IN work_fzrpauvhvnexhintldqhzusndm 8 18 the the DT work_fzrpauvhvnexhintldqhzusndm 8 19 challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 8 20 and and CC work_fzrpauvhvnexhintldqhzusndm 8 21 opportunities opportunity NNS work_fzrpauvhvnexhintldqhzusndm 8 22 afforded afford VBN work_fzrpauvhvnexhintldqhzusndm 8 23 by by IN work_fzrpauvhvnexhintldqhzusndm 8 24 this this DT work_fzrpauvhvnexhintldqhzusndm 8 25 new new JJ work_fzrpauvhvnexhintldqhzusndm 8 26 domain domain NN work_fzrpauvhvnexhintldqhzusndm 8 27 of of IN work_fzrpauvhvnexhintldqhzusndm 8 28 medical medical JJ work_fzrpauvhvnexhintldqhzusndm 8 29 science science NN work_fzrpauvhvnexhintldqhzusndm 8 30 . . . work_fzrpauvhvnexhintldqhzusndm 9 1 Keywords keyword NNS work_fzrpauvhvnexhintldqhzusndm 9 2 : : : work_fzrpauvhvnexhintldqhzusndm 9 3 multiomics multiomic NNS work_fzrpauvhvnexhintldqhzusndm 9 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 9 5 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 9 6 ; ; : work_fzrpauvhvnexhintldqhzusndm 9 7 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 9 8 system system NN work_fzrpauvhvnexhintldqhzusndm 9 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 9 10 development development NN work_fzrpauvhvnexhintldqhzusndm 9 11 ; ; : work_fzrpauvhvnexhintldqhzusndm 9 12 modernity modernity NN work_fzrpauvhvnexhintldqhzusndm 9 13 1 1 CD work_fzrpauvhvnexhintldqhzusndm 9 14 . . . work_fzrpauvhvnexhintldqhzusndm 10 1 Introduction introduction NN work_fzrpauvhvnexhintldqhzusndm 10 2 Over over IN work_fzrpauvhvnexhintldqhzusndm 10 3 the the DT work_fzrpauvhvnexhintldqhzusndm 10 4 past past JJ work_fzrpauvhvnexhintldqhzusndm 10 5 two two CD work_fzrpauvhvnexhintldqhzusndm 10 6 centuries century NNS work_fzrpauvhvnexhintldqhzusndm 10 7 , , , work_fzrpauvhvnexhintldqhzusndm 10 8 environmental environmental JJ work_fzrpauvhvnexhintldqhzusndm 10 9 changes change NNS work_fzrpauvhvnexhintldqhzusndm 10 10 associated associate VBN work_fzrpauvhvnexhintldqhzusndm 10 11 with with IN work_fzrpauvhvnexhintldqhzusndm 10 12 the the DT work_fzrpauvhvnexhintldqhzusndm 10 13 transition transition NN work_fzrpauvhvnexhintldqhzusndm 10 14 to to IN work_fzrpauvhvnexhintldqhzusndm 10 15 modernity modernity NN work_fzrpauvhvnexhintldqhzusndm 10 16 have have VBP work_fzrpauvhvnexhintldqhzusndm 10 17 brought bring VBN work_fzrpauvhvnexhintldqhzusndm 10 18 about about RP work_fzrpauvhvnexhintldqhzusndm 10 19 major major JJ work_fzrpauvhvnexhintldqhzusndm 10 20 demographic demographic NN work_fzrpauvhvnexhintldqhzusndm 10 21 , , , work_fzrpauvhvnexhintldqhzusndm 10 22 epidemiological epidemiological JJ work_fzrpauvhvnexhintldqhzusndm 10 23 , , , work_fzrpauvhvnexhintldqhzusndm 10 24 and and CC work_fzrpauvhvnexhintldqhzusndm 10 25 ecological ecological JJ work_fzrpauvhvnexhintldqhzusndm 10 26 changes change NNS work_fzrpauvhvnexhintldqhzusndm 10 27 which which WDT work_fzrpauvhvnexhintldqhzusndm 10 28 have have VBP work_fzrpauvhvnexhintldqhzusndm 10 29 had have VBN work_fzrpauvhvnexhintldqhzusndm 10 30 profound profound JJ work_fzrpauvhvnexhintldqhzusndm 10 31 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 10 32 on on IN work_fzrpauvhvnexhintldqhzusndm 10 33 human human JJ work_fzrpauvhvnexhintldqhzusndm 10 34 health health NN work_fzrpauvhvnexhintldqhzusndm 10 35 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 10 36 1 1 CD work_fzrpauvhvnexhintldqhzusndm 10 37 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 10 38 . . . work_fzrpauvhvnexhintldqhzusndm 11 1 Improvements improvement NNS work_fzrpauvhvnexhintldqhzusndm 11 2 in in IN work_fzrpauvhvnexhintldqhzusndm 11 3 public public JJ work_fzrpauvhvnexhintldqhzusndm 11 4 health health NN work_fzrpauvhvnexhintldqhzusndm 11 5 , , , work_fzrpauvhvnexhintldqhzusndm 11 6 hygiene hygiene NN work_fzrpauvhvnexhintldqhzusndm 11 7 , , , work_fzrpauvhvnexhintldqhzusndm 11 8 food food NN work_fzrpauvhvnexhintldqhzusndm 11 9 security security NN work_fzrpauvhvnexhintldqhzusndm 11 10 , , , work_fzrpauvhvnexhintldqhzusndm 11 11 transport transport NN work_fzrpauvhvnexhintldqhzusndm 11 12 , , , work_fzrpauvhvnexhintldqhzusndm 11 13 and and CC work_fzrpauvhvnexhintldqhzusndm 11 14 communication communication NN work_fzrpauvhvnexhintldqhzusndm 11 15 , , , work_fzrpauvhvnexhintldqhzusndm 11 16 plus plus CC work_fzrpauvhvnexhintldqhzusndm 11 17 increasing increase VBG work_fzrpauvhvnexhintldqhzusndm 11 18 population population NN work_fzrpauvhvnexhintldqhzusndm 11 19 growth growth NN work_fzrpauvhvnexhintldqhzusndm 11 20 , , , work_fzrpauvhvnexhintldqhzusndm 11 21 declining decline VBG work_fzrpauvhvnexhintldqhzusndm 11 22 global global JJ work_fzrpauvhvnexhintldqhzusndm 11 23 fertility fertility NN work_fzrpauvhvnexhintldqhzusndm 11 24 rates rate NNS work_fzrpauvhvnexhintldqhzusndm 11 25 , , , work_fzrpauvhvnexhintldqhzusndm 11 26 global global JJ work_fzrpauvhvnexhintldqhzusndm 11 27 migration migration NN work_fzrpauvhvnexhintldqhzusndm 11 28 , , , work_fzrpauvhvnexhintldqhzusndm 11 29 and and CC work_fzrpauvhvnexhintldqhzusndm 11 30 increased increase VBN work_fzrpauvhvnexhintldqhzusndm 11 31 exposure exposure NN work_fzrpauvhvnexhintldqhzusndm 11 32 to to IN work_fzrpauvhvnexhintldqhzusndm 11 33 industrial industrial JJ work_fzrpauvhvnexhintldqhzusndm 11 34 pollutants pollutant NNS work_fzrpauvhvnexhintldqhzusndm 11 35 have have VBP work_fzrpauvhvnexhintldqhzusndm 11 36 had have VBN work_fzrpauvhvnexhintldqhzusndm 11 37 major major JJ work_fzrpauvhvnexhintldqhzusndm 11 38 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 11 39 on on IN work_fzrpauvhvnexhintldqhzusndm 11 40 human human JJ work_fzrpauvhvnexhintldqhzusndm 11 41 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 11 42 development development NN work_fzrpauvhvnexhintldqhzusndm 11 43 and and CC work_fzrpauvhvnexhintldqhzusndm 11 44 the the DT work_fzrpauvhvnexhintldqhzusndm 11 45 microbiota microbiota NN work_fzrpauvhvnexhintldqhzusndm 11 46 . . . work_fzrpauvhvnexhintldqhzusndm 12 1 On on IN work_fzrpauvhvnexhintldqhzusndm 12 2 the the DT work_fzrpauvhvnexhintldqhzusndm 12 3 scale scale NN work_fzrpauvhvnexhintldqhzusndm 12 4 of of IN work_fzrpauvhvnexhintldqhzusndm 12 5 human human JJ work_fzrpauvhvnexhintldqhzusndm 12 6 evolution evolution NN work_fzrpauvhvnexhintldqhzusndm 12 7 , , , work_fzrpauvhvnexhintldqhzusndm 12 8 spanning span VBG work_fzrpauvhvnexhintldqhzusndm 12 9 hundreds hundred NNS work_fzrpauvhvnexhintldqhzusndm 12 10 of of IN work_fzrpauvhvnexhintldqhzusndm 12 11 thousands thousand NNS work_fzrpauvhvnexhintldqhzusndm 12 12 of of IN work_fzrpauvhvnexhintldqhzusndm 12 13 years year NNS work_fzrpauvhvnexhintldqhzusndm 12 14 , , , work_fzrpauvhvnexhintldqhzusndm 12 15 these these DT work_fzrpauvhvnexhintldqhzusndm 12 16 changes change NNS work_fzrpauvhvnexhintldqhzusndm 12 17 virtually virtually RB work_fzrpauvhvnexhintldqhzusndm 12 18 happened happen VBD work_fzrpauvhvnexhintldqhzusndm 12 19 yesterday yesterday NN work_fzrpauvhvnexhintldqhzusndm 12 20 morning morning NN work_fzrpauvhvnexhintldqhzusndm 12 21 , , , work_fzrpauvhvnexhintldqhzusndm 12 22 and and CC work_fzrpauvhvnexhintldqhzusndm 12 23 are be VBP work_fzrpauvhvnexhintldqhzusndm 12 24 now now RB work_fzrpauvhvnexhintldqhzusndm 12 25 associated associate VBN work_fzrpauvhvnexhintldqhzusndm 12 26 with with IN work_fzrpauvhvnexhintldqhzusndm 12 27 rising rise VBG work_fzrpauvhvnexhintldqhzusndm 12 28 rates rate NNS work_fzrpauvhvnexhintldqhzusndm 12 29 of of IN work_fzrpauvhvnexhintldqhzusndm 12 30 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 12 31 non non JJ work_fzrpauvhvnexhintldqhzusndm 12 32 - - JJ work_fzrpauvhvnexhintldqhzusndm 12 33 communicable communicable JJ work_fzrpauvhvnexhintldqhzusndm 12 34 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 12 35 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 12 36 NCDs NCDs NNPS work_fzrpauvhvnexhintldqhzusndm 12 37 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 12 38 across across IN work_fzrpauvhvnexhintldqhzusndm 12 39 the the DT work_fzrpauvhvnexhintldqhzusndm 12 40 globe globe NN work_fzrpauvhvnexhintldqhzusndm 12 41 , , , work_fzrpauvhvnexhintldqhzusndm 12 42 due due IN work_fzrpauvhvnexhintldqhzusndm 12 43 to to IN work_fzrpauvhvnexhintldqhzusndm 12 44 mismatches mismatch NNS work_fzrpauvhvnexhintldqhzusndm 12 45 between between IN work_fzrpauvhvnexhintldqhzusndm 12 46 our -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 12 47 evolved evolve VBN work_fzrpauvhvnexhintldqhzusndm 12 48 capacities capacity NNS work_fzrpauvhvnexhintldqhzusndm 12 49 and and CC work_fzrpauvhvnexhintldqhzusndm 12 50 modern modern JJ work_fzrpauvhvnexhintldqhzusndm 12 51 environments environment NNS work_fzrpauvhvnexhintldqhzusndm 12 52 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 12 53 2 2 CD work_fzrpauvhvnexhintldqhzusndm 12 54 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 12 55 . . . work_fzrpauvhvnexhintldqhzusndm 13 1 NCDs ncd NNS work_fzrpauvhvnexhintldqhzusndm 13 2 now now RB work_fzrpauvhvnexhintldqhzusndm 13 3 account account VBP work_fzrpauvhvnexhintldqhzusndm 13 4 for for IN work_fzrpauvhvnexhintldqhzusndm 13 5 the the DT work_fzrpauvhvnexhintldqhzusndm 13 6 major major JJ work_fzrpauvhvnexhintldqhzusndm 13 7 causes cause NNS work_fzrpauvhvnexhintldqhzusndm 13 8 of of IN work_fzrpauvhvnexhintldqhzusndm 13 9 human human JJ work_fzrpauvhvnexhintldqhzusndm 13 10 mortality mortality NN work_fzrpauvhvnexhintldqhzusndm 13 11 across across IN work_fzrpauvhvnexhintldqhzusndm 13 12 the the DT work_fzrpauvhvnexhintldqhzusndm 13 13 globe globe NN work_fzrpauvhvnexhintldqhzusndm 13 14 , , , work_fzrpauvhvnexhintldqhzusndm 13 15 whereas whereas IN work_fzrpauvhvnexhintldqhzusndm 13 16 previously previously RB work_fzrpauvhvnexhintldqhzusndm 13 17 infectious infectious JJ work_fzrpauvhvnexhintldqhzusndm 13 18 disease disease NN work_fzrpauvhvnexhintldqhzusndm 13 19 constituted constitute VBD work_fzrpauvhvnexhintldqhzusndm 13 20 the the DT work_fzrpauvhvnexhintldqhzusndm 13 21 major major JJ work_fzrpauvhvnexhintldqhzusndm 13 22 burden burden NN work_fzrpauvhvnexhintldqhzusndm 13 23 of of IN work_fzrpauvhvnexhintldqhzusndm 13 24 human human JJ work_fzrpauvhvnexhintldqhzusndm 13 25 mortality mortality NN work_fzrpauvhvnexhintldqhzusndm 13 26 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 13 27 3 3 CD work_fzrpauvhvnexhintldqhzusndm 13 28 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 13 29 . . . work_fzrpauvhvnexhintldqhzusndm 14 1 Immune immune JJ work_fzrpauvhvnexhintldqhzusndm 14 2 development development NN work_fzrpauvhvnexhintldqhzusndm 14 3 is be VBZ work_fzrpauvhvnexhintldqhzusndm 14 4 a a DT work_fzrpauvhvnexhintldqhzusndm 14 5 target target NN work_fzrpauvhvnexhintldqhzusndm 14 6 for for IN work_fzrpauvhvnexhintldqhzusndm 14 7 the the DT work_fzrpauvhvnexhintldqhzusndm 14 8 adverse adverse JJ work_fzrpauvhvnexhintldqhzusndm 14 9 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 14 10 of of IN work_fzrpauvhvnexhintldqhzusndm 14 11 modernization modernization NN work_fzrpauvhvnexhintldqhzusndm 14 12 since since IN work_fzrpauvhvnexhintldqhzusndm 14 13 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 14 14 inflammation inflammation NN work_fzrpauvhvnexhintldqhzusndm 14 15 and and CC work_fzrpauvhvnexhintldqhzusndm 14 16 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 14 17 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 14 18 are be VBP work_fzrpauvhvnexhintldqhzusndm 14 19 common common JJ work_fzrpauvhvnexhintldqhzusndm 14 20 risk risk NN work_fzrpauvhvnexhintldqhzusndm 14 21 factors factor NNS work_fzrpauvhvnexhintldqhzusndm 14 22 for for IN work_fzrpauvhvnexhintldqhzusndm 14 23 a a DT work_fzrpauvhvnexhintldqhzusndm 14 24 range range NN work_fzrpauvhvnexhintldqhzusndm 14 25 of of IN work_fzrpauvhvnexhintldqhzusndm 14 26 NCDs ncd NNS work_fzrpauvhvnexhintldqhzusndm 14 27 , , , work_fzrpauvhvnexhintldqhzusndm 14 28 including include VBG work_fzrpauvhvnexhintldqhzusndm 14 29 allergy allergy NN work_fzrpauvhvnexhintldqhzusndm 14 30 and and CC work_fzrpauvhvnexhintldqhzusndm 14 31 autoimmune autoimmune JJ work_fzrpauvhvnexhintldqhzusndm 14 32 disease disease NN work_fzrpauvhvnexhintldqhzusndm 14 33 , , , work_fzrpauvhvnexhintldqhzusndm 14 34 atherosclerotic atherosclerotic JJ work_fzrpauvhvnexhintldqhzusndm 14 35 disease disease NN work_fzrpauvhvnexhintldqhzusndm 14 36 , , , work_fzrpauvhvnexhintldqhzusndm 14 37 diabetes diabetes NN work_fzrpauvhvnexhintldqhzusndm 14 38 , , , work_fzrpauvhvnexhintldqhzusndm 14 39 and and CC work_fzrpauvhvnexhintldqhzusndm 14 40 cancer cancer NN work_fzrpauvhvnexhintldqhzusndm 14 41 , , , work_fzrpauvhvnexhintldqhzusndm 14 42 and and CC work_fzrpauvhvnexhintldqhzusndm 14 43 emerging emerge VBG work_fzrpauvhvnexhintldqhzusndm 14 44 evidence evidence NN work_fzrpauvhvnexhintldqhzusndm 14 45 now now RB work_fzrpauvhvnexhintldqhzusndm 14 46 suggests suggest VBZ work_fzrpauvhvnexhintldqhzusndm 14 47 links link NNS work_fzrpauvhvnexhintldqhzusndm 14 48 to to IN work_fzrpauvhvnexhintldqhzusndm 14 49 neurological neurological JJ work_fzrpauvhvnexhintldqhzusndm 14 50 disease disease NN work_fzrpauvhvnexhintldqhzusndm 14 51 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 14 52 reviewed review VBN work_fzrpauvhvnexhintldqhzusndm 14 53 in in IN work_fzrpauvhvnexhintldqhzusndm 14 54 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 14 55 4 4 CD work_fzrpauvhvnexhintldqhzusndm 14 56 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 14 57 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 14 58 . . . work_fzrpauvhvnexhintldqhzusndm 15 1 Efforts effort NNS work_fzrpauvhvnexhintldqhzusndm 15 2 to to TO work_fzrpauvhvnexhintldqhzusndm 15 3 understand understand VB work_fzrpauvhvnexhintldqhzusndm 15 4 the the DT work_fzrpauvhvnexhintldqhzusndm 15 5 mechanistic mechanistic JJ work_fzrpauvhvnexhintldqhzusndm 15 6 basis basis NN work_fzrpauvhvnexhintldqhzusndm 15 7 for for IN work_fzrpauvhvnexhintldqhzusndm 15 8 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 15 9 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 15 10 and and CC work_fzrpauvhvnexhintldqhzusndm 15 11 NCDs NCDs NNPS work_fzrpauvhvnexhintldqhzusndm 15 12 suggest suggest VBP work_fzrpauvhvnexhintldqhzusndm 15 13 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 15 14 multifactorial multifactorial JJ work_fzrpauvhvnexhintldqhzusndm 15 15 pathways pathway NNS work_fzrpauvhvnexhintldqhzusndm 15 16 of of IN work_fzrpauvhvnexhintldqhzusndm 15 17 disease disease NNP work_fzrpauvhvnexhintldqhzusndm 15 18 induction induction NN work_fzrpauvhvnexhintldqhzusndm 15 19 . . . work_fzrpauvhvnexhintldqhzusndm 16 1 Given give VBN work_fzrpauvhvnexhintldqhzusndm 16 2 the the DT work_fzrpauvhvnexhintldqhzusndm 16 3 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 16 4 pathways pathway NNS work_fzrpauvhvnexhintldqhzusndm 16 5 through through IN work_fzrpauvhvnexhintldqhzusndm 16 6 which which WDT work_fzrpauvhvnexhintldqhzusndm 16 7 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 16 8 trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 16 9 can can MD work_fzrpauvhvnexhintldqhzusndm 16 10 be be VB work_fzrpauvhvnexhintldqhzusndm 16 11 manipulated manipulate VBN work_fzrpauvhvnexhintldqhzusndm 16 12 by by IN work_fzrpauvhvnexhintldqhzusndm 16 13 the the DT work_fzrpauvhvnexhintldqhzusndm 16 14 sociodemographic sociodemographic JJ work_fzrpauvhvnexhintldqhzusndm 16 15 changes change NNS work_fzrpauvhvnexhintldqhzusndm 16 16 associated associate VBN work_fzrpauvhvnexhintldqhzusndm 16 17 with with IN work_fzrpauvhvnexhintldqhzusndm 16 18 modernity modernity NN work_fzrpauvhvnexhintldqhzusndm 16 19 , , , work_fzrpauvhvnexhintldqhzusndm 16 20 there there EX work_fzrpauvhvnexhintldqhzusndm 16 21 is be VBZ work_fzrpauvhvnexhintldqhzusndm 16 22 a a DT work_fzrpauvhvnexhintldqhzusndm 16 23 need need NN work_fzrpauvhvnexhintldqhzusndm 16 24 to to TO work_fzrpauvhvnexhintldqhzusndm 16 25 embrace embrace VB work_fzrpauvhvnexhintldqhzusndm 16 26 data data NN work_fzrpauvhvnexhintldqhzusndm 16 27 - - HYPH work_fzrpauvhvnexhintldqhzusndm 16 28 driven drive VBN work_fzrpauvhvnexhintldqhzusndm 16 29 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 16 30 of of IN work_fzrpauvhvnexhintldqhzusndm 16 31 increasing increase VBG work_fzrpauvhvnexhintldqhzusndm 16 32 complexity complexity NN work_fzrpauvhvnexhintldqhzusndm 16 33 to to TO work_fzrpauvhvnexhintldqhzusndm 16 34 better well RBR work_fzrpauvhvnexhintldqhzusndm 16 35 enable enable VB work_fzrpauvhvnexhintldqhzusndm 16 36 precision precision NN work_fzrpauvhvnexhintldqhzusndm 16 37 medicine medicine NN work_fzrpauvhvnexhintldqhzusndm 16 38 . . . work_fzrpauvhvnexhintldqhzusndm 17 1 Traditional traditional JJ work_fzrpauvhvnexhintldqhzusndm 17 2 reductionist reductionist JJ work_fzrpauvhvnexhintldqhzusndm 17 3 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 17 4 are be VBP work_fzrpauvhvnexhintldqhzusndm 17 5 ill ill RB work_fzrpauvhvnexhintldqhzusndm 17 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 17 7 suited suited JJ work_fzrpauvhvnexhintldqhzusndm 17 8 to to IN work_fzrpauvhvnexhintldqhzusndm 17 9 dealing deal VBG work_fzrpauvhvnexhintldqhzusndm 17 10 with with IN work_fzrpauvhvnexhintldqhzusndm 17 11 the the DT work_fzrpauvhvnexhintldqhzusndm 17 12 emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 17 13 properties property NNS work_fzrpauvhvnexhintldqhzusndm 17 14 of of IN work_fzrpauvhvnexhintldqhzusndm 17 15 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 17 16 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 17 17 systems system NNS work_fzrpauvhvnexhintldqhzusndm 17 18 , , , work_fzrpauvhvnexhintldqhzusndm 17 19 and and CC work_fzrpauvhvnexhintldqhzusndm 17 20 even even RB work_fzrpauvhvnexhintldqhzusndm 17 21 single single JJ work_fzrpauvhvnexhintldqhzusndm 17 22 ‘ ' `` work_fzrpauvhvnexhintldqhzusndm 17 23 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 17 24 ’ ’ POS work_fzrpauvhvnexhintldqhzusndm 17 25 medicine medicine NN work_fzrpauvhvnexhintldqhzusndm 17 26 is be VBZ work_fzrpauvhvnexhintldqhzusndm 17 27 proving prove VBG work_fzrpauvhvnexhintldqhzusndm 17 28 ill ill RB work_fzrpauvhvnexhintldqhzusndm 17 29 - - HYPH work_fzrpauvhvnexhintldqhzusndm 17 30 equipped equip VBN work_fzrpauvhvnexhintldqhzusndm 17 31 to to TO work_fzrpauvhvnexhintldqhzusndm 17 32 meet meet VB work_fzrpauvhvnexhintldqhzusndm 17 33 these these DT work_fzrpauvhvnexhintldqhzusndm 17 34 challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 17 35 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 17 36 5 5 CD work_fzrpauvhvnexhintldqhzusndm 17 37 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 17 38 . . . work_fzrpauvhvnexhintldqhzusndm 18 1 In in IN work_fzrpauvhvnexhintldqhzusndm 18 2 this this DT work_fzrpauvhvnexhintldqhzusndm 18 3 article article NN work_fzrpauvhvnexhintldqhzusndm 18 4 , , , work_fzrpauvhvnexhintldqhzusndm 18 5 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 18 6 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 18 7 , , , work_fzrpauvhvnexhintldqhzusndm 18 8 10 10 CD work_fzrpauvhvnexhintldqhzusndm 18 9 , , , work_fzrpauvhvnexhintldqhzusndm 18 10 23 23 CD work_fzrpauvhvnexhintldqhzusndm 18 11 ; ; : work_fzrpauvhvnexhintldqhzusndm 18 12 doi:10.3390 doi:10.3390 NNP work_fzrpauvhvnexhintldqhzusndm 18 13 / / SYM work_fzrpauvhvnexhintldqhzusndm 18 14 challe10010023 challe10010023 NNP work_fzrpauvhvnexhintldqhzusndm 18 15 www.mdpi.com/journal/challenges www.mdpi.com/journal/challenges '' work_fzrpauvhvnexhintldqhzusndm 18 16 http://www.mdpi.com/journal/challenges http://www.mdpi.com/journal/challenge VBZ work_fzrpauvhvnexhintldqhzusndm 18 17 http://www.mdpi.com http://www.mdpi.com ADD work_fzrpauvhvnexhintldqhzusndm 18 18 https://orcid.org/0000-0001-6823-4696 https://orcid.org/0000-0001-6823-4696 NNP work_fzrpauvhvnexhintldqhzusndm 18 19 http://www.mdpi.com/2078-1547/10/1/23?type=check_update&version=1 http://www.mdpi.com/2078-1547/10/1/23?type=check_update&version=1 NNP work_fzrpauvhvnexhintldqhzusndm 18 20 http://dx.doi.org/10.3390/challe10010023 http://dx.doi.org/10.3390/challe10010023 NNP work_fzrpauvhvnexhintldqhzusndm 18 21 http://www.mdpi.com/journal/challenges http://www.mdpi.com/journal/challenges NNP work_fzrpauvhvnexhintldqhzusndm 18 22 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 18 23 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 18 24 , , , work_fzrpauvhvnexhintldqhzusndm 18 25 10 10 CD work_fzrpauvhvnexhintldqhzusndm 18 26 , , , work_fzrpauvhvnexhintldqhzusndm 18 27 23 23 CD work_fzrpauvhvnexhintldqhzusndm 18 28 2 2 CD work_fzrpauvhvnexhintldqhzusndm 18 29 of of IN work_fzrpauvhvnexhintldqhzusndm 18 30 9 9 CD work_fzrpauvhvnexhintldqhzusndm 18 31 we -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 18 32 discuss discuss VBP work_fzrpauvhvnexhintldqhzusndm 18 33 the the DT work_fzrpauvhvnexhintldqhzusndm 18 34 potential potential JJ work_fzrpauvhvnexhintldqhzusndm 18 35 opportunities opportunity NNS work_fzrpauvhvnexhintldqhzusndm 18 36 afforded afford VBN work_fzrpauvhvnexhintldqhzusndm 18 37 by by IN work_fzrpauvhvnexhintldqhzusndm 18 38 integrated integrate VBN work_fzrpauvhvnexhintldqhzusndm 18 39 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 18 40 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 18 41 powered power VBN work_fzrpauvhvnexhintldqhzusndm 18 42 by by IN work_fzrpauvhvnexhintldqhzusndm 18 43 pattern pattern NN work_fzrpauvhvnexhintldqhzusndm 18 44 - - HYPH work_fzrpauvhvnexhintldqhzusndm 18 45 finding find VBG work_fzrpauvhvnexhintldqhzusndm 18 46 algorithms algorithm NNS work_fzrpauvhvnexhintldqhzusndm 18 47 to to TO work_fzrpauvhvnexhintldqhzusndm 18 48 better well RBR work_fzrpauvhvnexhintldqhzusndm 18 49 understand understand VB work_fzrpauvhvnexhintldqhzusndm 18 50 the the DT work_fzrpauvhvnexhintldqhzusndm 18 51 basis basis NN work_fzrpauvhvnexhintldqhzusndm 18 52 for for IN work_fzrpauvhvnexhintldqhzusndm 18 53 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 18 54 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 18 55 over over IN work_fzrpauvhvnexhintldqhzusndm 18 56 a a DT work_fzrpauvhvnexhintldqhzusndm 18 57 life life NN work_fzrpauvhvnexhintldqhzusndm 18 58 course course NN work_fzrpauvhvnexhintldqhzusndm 18 59 . . . work_fzrpauvhvnexhintldqhzusndm 19 1 2 2 LS work_fzrpauvhvnexhintldqhzusndm 19 2 . . . work_fzrpauvhvnexhintldqhzusndm 20 1 Perinatal perinatal JJ work_fzrpauvhvnexhintldqhzusndm 20 2 Influences Influences NNPS work_fzrpauvhvnexhintldqhzusndm 20 3 on on IN work_fzrpauvhvnexhintldqhzusndm 20 4 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 20 5 Development Development NNP work_fzrpauvhvnexhintldqhzusndm 20 6 and and CC work_fzrpauvhvnexhintldqhzusndm 20 7 Chronic Chronic NNP work_fzrpauvhvnexhintldqhzusndm 20 8 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 20 9 It -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 20 10 is be VBZ work_fzrpauvhvnexhintldqhzusndm 20 11 now now RB work_fzrpauvhvnexhintldqhzusndm 20 12 recognized recognize VBN work_fzrpauvhvnexhintldqhzusndm 20 13 that that IN work_fzrpauvhvnexhintldqhzusndm 20 14 the the DT work_fzrpauvhvnexhintldqhzusndm 20 15 first first JJ work_fzrpauvhvnexhintldqhzusndm 20 16 thousand thousand CD work_fzrpauvhvnexhintldqhzusndm 20 17 days day NNS work_fzrpauvhvnexhintldqhzusndm 20 18 of of IN work_fzrpauvhvnexhintldqhzusndm 20 19 life life NN work_fzrpauvhvnexhintldqhzusndm 20 20 between between IN work_fzrpauvhvnexhintldqhzusndm 20 21 conception conception NN work_fzrpauvhvnexhintldqhzusndm 20 22 and and CC work_fzrpauvhvnexhintldqhzusndm 20 23 age age NN work_fzrpauvhvnexhintldqhzusndm 20 24 two two CD work_fzrpauvhvnexhintldqhzusndm 20 25 are be VBP work_fzrpauvhvnexhintldqhzusndm 20 26 a a DT work_fzrpauvhvnexhintldqhzusndm 20 27 crucial crucial JJ work_fzrpauvhvnexhintldqhzusndm 20 28 period period NN work_fzrpauvhvnexhintldqhzusndm 20 29 of of IN work_fzrpauvhvnexhintldqhzusndm 20 30 heightened heightened JJ work_fzrpauvhvnexhintldqhzusndm 20 31 plasticity plasticity NN work_fzrpauvhvnexhintldqhzusndm 20 32 , , , work_fzrpauvhvnexhintldqhzusndm 20 33 in in IN work_fzrpauvhvnexhintldqhzusndm 20 34 which which WDT work_fzrpauvhvnexhintldqhzusndm 20 35 the the DT work_fzrpauvhvnexhintldqhzusndm 20 36 developing develop VBG work_fzrpauvhvnexhintldqhzusndm 20 37 brain brain NN work_fzrpauvhvnexhintldqhzusndm 20 38 and and CC work_fzrpauvhvnexhintldqhzusndm 20 39 the the DT work_fzrpauvhvnexhintldqhzusndm 20 40 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 20 41 system system NN work_fzrpauvhvnexhintldqhzusndm 20 42 are be VBP work_fzrpauvhvnexhintldqhzusndm 20 43 highly highly RB work_fzrpauvhvnexhintldqhzusndm 20 44 sensitive sensitive JJ work_fzrpauvhvnexhintldqhzusndm 20 45 to to IN work_fzrpauvhvnexhintldqhzusndm 20 46 influences influence NNS work_fzrpauvhvnexhintldqhzusndm 20 47 from from IN work_fzrpauvhvnexhintldqhzusndm 20 48 the the DT work_fzrpauvhvnexhintldqhzusndm 20 49 environment environment NN work_fzrpauvhvnexhintldqhzusndm 20 50 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 20 51 6 6 CD work_fzrpauvhvnexhintldqhzusndm 20 52 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 20 53 . . . work_fzrpauvhvnexhintldqhzusndm 21 1 Poor poor JJ work_fzrpauvhvnexhintldqhzusndm 21 2 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 21 3 experience experience NN work_fzrpauvhvnexhintldqhzusndm 21 4 brought bring VBN work_fzrpauvhvnexhintldqhzusndm 21 5 about about RP work_fzrpauvhvnexhintldqhzusndm 21 6 by by IN work_fzrpauvhvnexhintldqhzusndm 21 7 adverse adverse JJ work_fzrpauvhvnexhintldqhzusndm 21 8 exposures exposure NNS work_fzrpauvhvnexhintldqhzusndm 21 9 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 21 10 e.g. e.g. RB work_fzrpauvhvnexhintldqhzusndm 21 11 , , , work_fzrpauvhvnexhintldqhzusndm 21 12 maternal maternal JJ work_fzrpauvhvnexhintldqhzusndm 21 13 stress stress NN work_fzrpauvhvnexhintldqhzusndm 21 14 , , , work_fzrpauvhvnexhintldqhzusndm 21 15 poor poor JJ work_fzrpauvhvnexhintldqhzusndm 21 16 nutrition nutrition NN work_fzrpauvhvnexhintldqhzusndm 21 17 , , , work_fzrpauvhvnexhintldqhzusndm 21 18 infections infection NNS work_fzrpauvhvnexhintldqhzusndm 21 19 , , , work_fzrpauvhvnexhintldqhzusndm 21 20 toxins toxin NNS work_fzrpauvhvnexhintldqhzusndm 21 21 and and CC work_fzrpauvhvnexhintldqhzusndm 21 22 pollutants pollutant NNS work_fzrpauvhvnexhintldqhzusndm 21 23 , , , work_fzrpauvhvnexhintldqhzusndm 21 24 alcohol alcohol NN work_fzrpauvhvnexhintldqhzusndm 21 25 , , , work_fzrpauvhvnexhintldqhzusndm 21 26 tobacco tobacco NN work_fzrpauvhvnexhintldqhzusndm 21 27 smoke smoke NN work_fzrpauvhvnexhintldqhzusndm 21 28 , , , work_fzrpauvhvnexhintldqhzusndm 21 29 and and CC work_fzrpauvhvnexhintldqhzusndm 21 30 antibiotics antibiotic NNS work_fzrpauvhvnexhintldqhzusndm 21 31 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 21 32 during during IN work_fzrpauvhvnexhintldqhzusndm 21 33 the the DT work_fzrpauvhvnexhintldqhzusndm 21 34 perinatal perinatal JJ work_fzrpauvhvnexhintldqhzusndm 21 35 period period NN work_fzrpauvhvnexhintldqhzusndm 21 36 have have VBP work_fzrpauvhvnexhintldqhzusndm 21 37 a a DT work_fzrpauvhvnexhintldqhzusndm 21 38 greater great JJR work_fzrpauvhvnexhintldqhzusndm 21 39 capacity capacity NN work_fzrpauvhvnexhintldqhzusndm 21 40 to to TO work_fzrpauvhvnexhintldqhzusndm 21 41 alter alter VB work_fzrpauvhvnexhintldqhzusndm 21 42 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 21 43 trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 21 44 , , , work_fzrpauvhvnexhintldqhzusndm 21 45 potentially potentially RB work_fzrpauvhvnexhintldqhzusndm 21 46 increasing increase VBG work_fzrpauvhvnexhintldqhzusndm 21 47 the the DT work_fzrpauvhvnexhintldqhzusndm 21 48 risk risk NN work_fzrpauvhvnexhintldqhzusndm 21 49 for for IN work_fzrpauvhvnexhintldqhzusndm 21 50 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 21 51 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 21 52 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 21 53 7 7 CD work_fzrpauvhvnexhintldqhzusndm 21 54 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 21 55 . . . work_fzrpauvhvnexhintldqhzusndm 22 1 Preterm preterm JJ work_fzrpauvhvnexhintldqhzusndm 22 2 birth birth NN work_fzrpauvhvnexhintldqhzusndm 22 3 is be VBZ work_fzrpauvhvnexhintldqhzusndm 22 4 a a DT work_fzrpauvhvnexhintldqhzusndm 22 5 prototypical prototypical JJ work_fzrpauvhvnexhintldqhzusndm 22 6 example example NN work_fzrpauvhvnexhintldqhzusndm 22 7 of of IN work_fzrpauvhvnexhintldqhzusndm 22 8 a a DT work_fzrpauvhvnexhintldqhzusndm 22 9 suboptimal suboptimal JJ work_fzrpauvhvnexhintldqhzusndm 22 10 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 22 11 experience experience NN work_fzrpauvhvnexhintldqhzusndm 22 12 with with IN work_fzrpauvhvnexhintldqhzusndm 22 13 well well RB work_fzrpauvhvnexhintldqhzusndm 22 14 - - HYPH work_fzrpauvhvnexhintldqhzusndm 22 15 described describe VBN work_fzrpauvhvnexhintldqhzusndm 22 16 heath heath NN work_fzrpauvhvnexhintldqhzusndm 22 17 consequences consequence NNS work_fzrpauvhvnexhintldqhzusndm 22 18 in in IN work_fzrpauvhvnexhintldqhzusndm 22 19 later later JJ work_fzrpauvhvnexhintldqhzusndm 22 20 life life NN work_fzrpauvhvnexhintldqhzusndm 22 21 . . . work_fzrpauvhvnexhintldqhzusndm 23 1 Recent recent JJ work_fzrpauvhvnexhintldqhzusndm 23 2 findings finding NNS work_fzrpauvhvnexhintldqhzusndm 23 3 from from IN work_fzrpauvhvnexhintldqhzusndm 23 4 a a DT work_fzrpauvhvnexhintldqhzusndm 23 5 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 23 6 study study NN work_fzrpauvhvnexhintldqhzusndm 23 7 of of IN work_fzrpauvhvnexhintldqhzusndm 23 8 preterm preterm NNP work_fzrpauvhvnexhintldqhzusndm 23 9 neonates neonates NNPS work_fzrpauvhvnexhintldqhzusndm 23 10 supports support VBZ work_fzrpauvhvnexhintldqhzusndm 23 11 the the DT work_fzrpauvhvnexhintldqhzusndm 23 12 notion notion NN work_fzrpauvhvnexhintldqhzusndm 23 13 of of IN work_fzrpauvhvnexhintldqhzusndm 23 14 altered alter VBN work_fzrpauvhvnexhintldqhzusndm 23 15 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 23 16 trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 23 17 . . . work_fzrpauvhvnexhintldqhzusndm 24 1 In in IN work_fzrpauvhvnexhintldqhzusndm 24 2 this this DT work_fzrpauvhvnexhintldqhzusndm 24 3 study study NN work_fzrpauvhvnexhintldqhzusndm 24 4 , , , work_fzrpauvhvnexhintldqhzusndm 24 5 cellular cellular JJ work_fzrpauvhvnexhintldqhzusndm 24 6 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 24 7 profiles profile NNS work_fzrpauvhvnexhintldqhzusndm 24 8 , , , work_fzrpauvhvnexhintldqhzusndm 24 9 blood blood NN work_fzrpauvhvnexhintldqhzusndm 24 10 transcriptomes transcriptome NNS work_fzrpauvhvnexhintldqhzusndm 24 11 , , , work_fzrpauvhvnexhintldqhzusndm 24 12 plasma plasma NN work_fzrpauvhvnexhintldqhzusndm 24 13 proteins protein NNS work_fzrpauvhvnexhintldqhzusndm 24 14 , , , work_fzrpauvhvnexhintldqhzusndm 24 15 and and CC work_fzrpauvhvnexhintldqhzusndm 24 16 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 24 17 profiles profile NNS work_fzrpauvhvnexhintldqhzusndm 24 18 were be VBD work_fzrpauvhvnexhintldqhzusndm 24 19 assessed assess VBN work_fzrpauvhvnexhintldqhzusndm 24 20 at at IN work_fzrpauvhvnexhintldqhzusndm 24 21 birth birth NN work_fzrpauvhvnexhintldqhzusndm 24 22 in in IN work_fzrpauvhvnexhintldqhzusndm 24 23 cord cord NN work_fzrpauvhvnexhintldqhzusndm 24 24 blood blood NN work_fzrpauvhvnexhintldqhzusndm 24 25 , , , work_fzrpauvhvnexhintldqhzusndm 24 26 and and CC work_fzrpauvhvnexhintldqhzusndm 24 27 at at IN work_fzrpauvhvnexhintldqhzusndm 24 28 1 1 CD work_fzrpauvhvnexhintldqhzusndm 24 29 , , , work_fzrpauvhvnexhintldqhzusndm 24 30 2 2 CD work_fzrpauvhvnexhintldqhzusndm 24 31 , , , work_fzrpauvhvnexhintldqhzusndm 24 32 and and CC work_fzrpauvhvnexhintldqhzusndm 24 33 12 12 CD work_fzrpauvhvnexhintldqhzusndm 24 34 weeks week NNS work_fzrpauvhvnexhintldqhzusndm 24 35 of of IN work_fzrpauvhvnexhintldqhzusndm 24 36 age age NN work_fzrpauvhvnexhintldqhzusndm 24 37 in in IN work_fzrpauvhvnexhintldqhzusndm 24 38 a a DT work_fzrpauvhvnexhintldqhzusndm 24 39 cohort cohort NN work_fzrpauvhvnexhintldqhzusndm 24 40 of of IN work_fzrpauvhvnexhintldqhzusndm 24 41 100 100 CD work_fzrpauvhvnexhintldqhzusndm 24 42 infants infant NNS work_fzrpauvhvnexhintldqhzusndm 24 43 , , , work_fzrpauvhvnexhintldqhzusndm 24 44 delivered deliver VBD work_fzrpauvhvnexhintldqhzusndm 24 45 preterm preterm NNP work_fzrpauvhvnexhintldqhzusndm 24 46 or or CC work_fzrpauvhvnexhintldqhzusndm 24 47 at at IN work_fzrpauvhvnexhintldqhzusndm 24 48 term term NN work_fzrpauvhvnexhintldqhzusndm 24 49 . . . work_fzrpauvhvnexhintldqhzusndm 25 1 These these DT work_fzrpauvhvnexhintldqhzusndm 25 2 data datum NNS work_fzrpauvhvnexhintldqhzusndm 25 3 , , , work_fzrpauvhvnexhintldqhzusndm 25 4 in in IN work_fzrpauvhvnexhintldqhzusndm 25 5 combination combination NN work_fzrpauvhvnexhintldqhzusndm 25 6 with with IN work_fzrpauvhvnexhintldqhzusndm 25 7 systems system NNS work_fzrpauvhvnexhintldqhzusndm 25 8 biology biology NN work_fzrpauvhvnexhintldqhzusndm 25 9 methods method NNS work_fzrpauvhvnexhintldqhzusndm 25 10 , , , work_fzrpauvhvnexhintldqhzusndm 25 11 demonstrated demonstrate VBD work_fzrpauvhvnexhintldqhzusndm 25 12 that that IN work_fzrpauvhvnexhintldqhzusndm 25 13 preterm preterm NN work_fzrpauvhvnexhintldqhzusndm 25 14 and and CC work_fzrpauvhvnexhintldqhzusndm 25 15 term term NN work_fzrpauvhvnexhintldqhzusndm 25 16 infants infant NNS work_fzrpauvhvnexhintldqhzusndm 25 17 followed follow VBD work_fzrpauvhvnexhintldqhzusndm 25 18 largely largely RB work_fzrpauvhvnexhintldqhzusndm 25 19 distinct distinct JJ work_fzrpauvhvnexhintldqhzusndm 25 20 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 25 21 trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 25 22 that that WDT work_fzrpauvhvnexhintldqhzusndm 25 23 converged converge VBN work_fzrpauvhvnexhintldqhzusndm 25 24 by by IN work_fzrpauvhvnexhintldqhzusndm 25 25 around around RB work_fzrpauvhvnexhintldqhzusndm 25 26 three three CD work_fzrpauvhvnexhintldqhzusndm 25 27 months month NNS work_fzrpauvhvnexhintldqhzusndm 25 28 of of IN work_fzrpauvhvnexhintldqhzusndm 25 29 age age NN work_fzrpauvhvnexhintldqhzusndm 25 30 . . . work_fzrpauvhvnexhintldqhzusndm 26 1 This this DT work_fzrpauvhvnexhintldqhzusndm 26 2 convergence convergence NN work_fzrpauvhvnexhintldqhzusndm 26 3 toward toward IN work_fzrpauvhvnexhintldqhzusndm 26 4 a a DT work_fzrpauvhvnexhintldqhzusndm 26 5 stereotypical stereotypical JJ work_fzrpauvhvnexhintldqhzusndm 26 6 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 26 7 trajectory trajectory NN work_fzrpauvhvnexhintldqhzusndm 26 8 was be VBD work_fzrpauvhvnexhintldqhzusndm 26 9 ostensibly ostensibly RB work_fzrpauvhvnexhintldqhzusndm 26 10 linked link VBN work_fzrpauvhvnexhintldqhzusndm 26 11 to to IN work_fzrpauvhvnexhintldqhzusndm 26 12 microbial microbial JJ work_fzrpauvhvnexhintldqhzusndm 26 13 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 26 14 in in IN work_fzrpauvhvnexhintldqhzusndm 26 15 early early JJ work_fzrpauvhvnexhintldqhzusndm 26 16 life life NN work_fzrpauvhvnexhintldqhzusndm 26 17 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 26 18 8 8 CD work_fzrpauvhvnexhintldqhzusndm 26 19 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 26 20 . . . work_fzrpauvhvnexhintldqhzusndm 27 1 Microbial microbial JJ work_fzrpauvhvnexhintldqhzusndm 27 2 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 27 3 have have VBP work_fzrpauvhvnexhintldqhzusndm 27 4 long long RB work_fzrpauvhvnexhintldqhzusndm 27 5 been be VBN work_fzrpauvhvnexhintldqhzusndm 27 6 recognized recognize VBN work_fzrpauvhvnexhintldqhzusndm 27 7 as as IN work_fzrpauvhvnexhintldqhzusndm 27 8 potent potent JJ work_fzrpauvhvnexhintldqhzusndm 27 9 signals signal NNS work_fzrpauvhvnexhintldqhzusndm 27 10 that that WDT work_fzrpauvhvnexhintldqhzusndm 27 11 promote promote VBP work_fzrpauvhvnexhintldqhzusndm 27 12 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 27 13 development development NN work_fzrpauvhvnexhintldqhzusndm 27 14 , , , work_fzrpauvhvnexhintldqhzusndm 27 15 and and CC work_fzrpauvhvnexhintldqhzusndm 27 16 disruption disruption NN work_fzrpauvhvnexhintldqhzusndm 27 17 of of IN work_fzrpauvhvnexhintldqhzusndm 27 18 the the DT work_fzrpauvhvnexhintldqhzusndm 27 19 microbial microbial JJ work_fzrpauvhvnexhintldqhzusndm 27 20 ecology ecology NN work_fzrpauvhvnexhintldqhzusndm 27 21 brought bring VBN work_fzrpauvhvnexhintldqhzusndm 27 22 by by IN work_fzrpauvhvnexhintldqhzusndm 27 23 modernization modernization NN work_fzrpauvhvnexhintldqhzusndm 27 24 is be VBZ work_fzrpauvhvnexhintldqhzusndm 27 25 increasingly increasingly RB work_fzrpauvhvnexhintldqhzusndm 27 26 recognized recognize VBN work_fzrpauvhvnexhintldqhzusndm 27 27 as as IN work_fzrpauvhvnexhintldqhzusndm 27 28 a a DT work_fzrpauvhvnexhintldqhzusndm 27 29 key key JJ work_fzrpauvhvnexhintldqhzusndm 27 30 risk risk NN work_fzrpauvhvnexhintldqhzusndm 27 31 factor factor NN work_fzrpauvhvnexhintldqhzusndm 27 32 in in IN work_fzrpauvhvnexhintldqhzusndm 27 33 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 27 34 disease disease NN work_fzrpauvhvnexhintldqhzusndm 27 35 research research NN work_fzrpauvhvnexhintldqhzusndm 27 36 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 27 37 9,10 9,10 NN work_fzrpauvhvnexhintldqhzusndm 27 38 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 27 39 . . . work_fzrpauvhvnexhintldqhzusndm 28 1 Given give VBN work_fzrpauvhvnexhintldqhzusndm 28 2 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 28 3 development development NN work_fzrpauvhvnexhintldqhzusndm 28 4 is be VBZ work_fzrpauvhvnexhintldqhzusndm 28 5 intimately intimately RB work_fzrpauvhvnexhintldqhzusndm 28 6 coupled couple VBN work_fzrpauvhvnexhintldqhzusndm 28 7 to to IN work_fzrpauvhvnexhintldqhzusndm 28 8 microbial microbial JJ work_fzrpauvhvnexhintldqhzusndm 28 9 signaling signaling NN work_fzrpauvhvnexhintldqhzusndm 28 10 , , , work_fzrpauvhvnexhintldqhzusndm 28 11 dysbiosis dysbiosis NN work_fzrpauvhvnexhintldqhzusndm 28 12 of of IN work_fzrpauvhvnexhintldqhzusndm 28 13 the the DT work_fzrpauvhvnexhintldqhzusndm 28 14 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 28 15 in in IN work_fzrpauvhvnexhintldqhzusndm 28 16 early early JJ work_fzrpauvhvnexhintldqhzusndm 28 17 childhood childhood NN work_fzrpauvhvnexhintldqhzusndm 28 18 has have VBZ work_fzrpauvhvnexhintldqhzusndm 28 19 been be VBN work_fzrpauvhvnexhintldqhzusndm 28 20 linked link VBN work_fzrpauvhvnexhintldqhzusndm 28 21 to to IN work_fzrpauvhvnexhintldqhzusndm 28 22 virtually virtually RB work_fzrpauvhvnexhintldqhzusndm 28 23 every every DT work_fzrpauvhvnexhintldqhzusndm 28 24 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 28 25 disease disease NN work_fzrpauvhvnexhintldqhzusndm 28 26 of of IN work_fzrpauvhvnexhintldqhzusndm 28 27 the the DT work_fzrpauvhvnexhintldqhzusndm 28 28 modern modern JJ work_fzrpauvhvnexhintldqhzusndm 28 29 era era NN work_fzrpauvhvnexhintldqhzusndm 28 30 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 28 31 11 11 CD work_fzrpauvhvnexhintldqhzusndm 28 32 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 28 33 . . . work_fzrpauvhvnexhintldqhzusndm 29 1 Nowhere nowhere RB work_fzrpauvhvnexhintldqhzusndm 29 2 has have VBZ work_fzrpauvhvnexhintldqhzusndm 29 3 this this DT work_fzrpauvhvnexhintldqhzusndm 29 4 been be VBN work_fzrpauvhvnexhintldqhzusndm 29 5 more more RBR work_fzrpauvhvnexhintldqhzusndm 29 6 clearly clearly RB work_fzrpauvhvnexhintldqhzusndm 29 7 demonstrated demonstrate VBN work_fzrpauvhvnexhintldqhzusndm 29 8 than than IN work_fzrpauvhvnexhintldqhzusndm 29 9 in in IN work_fzrpauvhvnexhintldqhzusndm 29 10 the the DT work_fzrpauvhvnexhintldqhzusndm 29 11 Amish Amish NNP work_fzrpauvhvnexhintldqhzusndm 29 12 and and CC work_fzrpauvhvnexhintldqhzusndm 29 13 Hutterite Hutterite NNP work_fzrpauvhvnexhintldqhzusndm 29 14 story story NN work_fzrpauvhvnexhintldqhzusndm 29 15 . . . work_fzrpauvhvnexhintldqhzusndm 30 1 The the DT work_fzrpauvhvnexhintldqhzusndm 30 2 Amish amish JJ work_fzrpauvhvnexhintldqhzusndm 30 3 and and CC work_fzrpauvhvnexhintldqhzusndm 30 4 Hutterite Hutterite NNP work_fzrpauvhvnexhintldqhzusndm 30 5 populations population NNS work_fzrpauvhvnexhintldqhzusndm 30 6 living live VBG work_fzrpauvhvnexhintldqhzusndm 30 7 in in IN work_fzrpauvhvnexhintldqhzusndm 30 8 the the DT work_fzrpauvhvnexhintldqhzusndm 30 9 United United NNP work_fzrpauvhvnexhintldqhzusndm 30 10 States States NNP work_fzrpauvhvnexhintldqhzusndm 30 11 have have VBP work_fzrpauvhvnexhintldqhzusndm 30 12 a a DT work_fzrpauvhvnexhintldqhzusndm 30 13 similar similar JJ work_fzrpauvhvnexhintldqhzusndm 30 14 genetic genetic JJ work_fzrpauvhvnexhintldqhzusndm 30 15 background background NN work_fzrpauvhvnexhintldqhzusndm 30 16 , , , work_fzrpauvhvnexhintldqhzusndm 30 17 diet diet NN work_fzrpauvhvnexhintldqhzusndm 30 18 , , , work_fzrpauvhvnexhintldqhzusndm 30 19 and and CC work_fzrpauvhvnexhintldqhzusndm 30 20 lifestyle lifestyle NN work_fzrpauvhvnexhintldqhzusndm 30 21 , , , work_fzrpauvhvnexhintldqhzusndm 30 22 with with IN work_fzrpauvhvnexhintldqhzusndm 30 23 the the DT work_fzrpauvhvnexhintldqhzusndm 30 24 exception exception NN work_fzrpauvhvnexhintldqhzusndm 30 25 that that WDT work_fzrpauvhvnexhintldqhzusndm 30 26 the the DT work_fzrpauvhvnexhintldqhzusndm 30 27 Amish amish JJ work_fzrpauvhvnexhintldqhzusndm 30 28 use use VBP work_fzrpauvhvnexhintldqhzusndm 30 29 traditional traditional JJ work_fzrpauvhvnexhintldqhzusndm 30 30 farming farming NN work_fzrpauvhvnexhintldqhzusndm 30 31 methods method NNS work_fzrpauvhvnexhintldqhzusndm 30 32 and and CC work_fzrpauvhvnexhintldqhzusndm 30 33 live live VBP work_fzrpauvhvnexhintldqhzusndm 30 34 in in IN work_fzrpauvhvnexhintldqhzusndm 30 35 close close JJ work_fzrpauvhvnexhintldqhzusndm 30 36 proximity proximity NN work_fzrpauvhvnexhintldqhzusndm 30 37 to to IN work_fzrpauvhvnexhintldqhzusndm 30 38 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 30 39 animals animal NNS work_fzrpauvhvnexhintldqhzusndm 30 40 . . . work_fzrpauvhvnexhintldqhzusndm 31 1 By by IN work_fzrpauvhvnexhintldqhzusndm 31 2 contrast contrast NN work_fzrpauvhvnexhintldqhzusndm 31 3 , , , work_fzrpauvhvnexhintldqhzusndm 31 4 the the DT work_fzrpauvhvnexhintldqhzusndm 31 5 Hutterites Hutterites NNPS work_fzrpauvhvnexhintldqhzusndm 31 6 employ employ VBP work_fzrpauvhvnexhintldqhzusndm 31 7 highly highly RB work_fzrpauvhvnexhintldqhzusndm 31 8 industrialized industrialized JJ work_fzrpauvhvnexhintldqhzusndm 31 9 farming farming NN work_fzrpauvhvnexhintldqhzusndm 31 10 methods method NNS work_fzrpauvhvnexhintldqhzusndm 31 11 , , , work_fzrpauvhvnexhintldqhzusndm 31 12 and and CC work_fzrpauvhvnexhintldqhzusndm 31 13 the the DT work_fzrpauvhvnexhintldqhzusndm 31 14 animals animal NNS work_fzrpauvhvnexhintldqhzusndm 31 15 are be VBP work_fzrpauvhvnexhintldqhzusndm 31 16 housed house VBN work_fzrpauvhvnexhintldqhzusndm 31 17 in in IN work_fzrpauvhvnexhintldqhzusndm 31 18 large large JJ work_fzrpauvhvnexhintldqhzusndm 31 19 facilities facility NNS work_fzrpauvhvnexhintldqhzusndm 31 20 away away RB work_fzrpauvhvnexhintldqhzusndm 31 21 from from IN work_fzrpauvhvnexhintldqhzusndm 31 22 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 31 23 homes home NNS work_fzrpauvhvnexhintldqhzusndm 31 24 . . . work_fzrpauvhvnexhintldqhzusndm 32 1 Airborne airborne JJ work_fzrpauvhvnexhintldqhzusndm 32 2 dust dust NN work_fzrpauvhvnexhintldqhzusndm 32 3 samples sample NNS work_fzrpauvhvnexhintldqhzusndm 32 4 collected collect VBN work_fzrpauvhvnexhintldqhzusndm 32 5 from from IN work_fzrpauvhvnexhintldqhzusndm 32 6 Amish amish JJ work_fzrpauvhvnexhintldqhzusndm 32 7 homes home NNS work_fzrpauvhvnexhintldqhzusndm 32 8 were be VBD work_fzrpauvhvnexhintldqhzusndm 32 9 found find VBN work_fzrpauvhvnexhintldqhzusndm 32 10 to to TO work_fzrpauvhvnexhintldqhzusndm 32 11 have have VB work_fzrpauvhvnexhintldqhzusndm 32 12 elevated elevate VBN work_fzrpauvhvnexhintldqhzusndm 32 13 levels level NNS work_fzrpauvhvnexhintldqhzusndm 32 14 of of IN work_fzrpauvhvnexhintldqhzusndm 32 15 microbial microbial JJ work_fzrpauvhvnexhintldqhzusndm 32 16 endotoxin endotoxin NN work_fzrpauvhvnexhintldqhzusndm 32 17 , , , work_fzrpauvhvnexhintldqhzusndm 32 18 which which WDT work_fzrpauvhvnexhintldqhzusndm 32 19 was be VBD work_fzrpauvhvnexhintldqhzusndm 32 20 associated associate VBN work_fzrpauvhvnexhintldqhzusndm 32 21 with with IN work_fzrpauvhvnexhintldqhzusndm 32 22 markers marker NNS work_fzrpauvhvnexhintldqhzusndm 32 23 of of IN work_fzrpauvhvnexhintldqhzusndm 32 24 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 32 25 maturation maturation NN work_fzrpauvhvnexhintldqhzusndm 32 26 from from IN work_fzrpauvhvnexhintldqhzusndm 32 27 sampled sample VBN work_fzrpauvhvnexhintldqhzusndm 32 28 blood blood NN work_fzrpauvhvnexhintldqhzusndm 32 29 , , , work_fzrpauvhvnexhintldqhzusndm 32 30 and and CC work_fzrpauvhvnexhintldqhzusndm 32 31 a a DT work_fzrpauvhvnexhintldqhzusndm 32 32 four four CD work_fzrpauvhvnexhintldqhzusndm 32 33 - - HYPH work_fzrpauvhvnexhintldqhzusndm 32 34 fold fold JJ work_fzrpauvhvnexhintldqhzusndm 32 35 reduction reduction NN work_fzrpauvhvnexhintldqhzusndm 32 36 in in IN work_fzrpauvhvnexhintldqhzusndm 32 37 the the DT work_fzrpauvhvnexhintldqhzusndm 32 38 rates rate NNS work_fzrpauvhvnexhintldqhzusndm 32 39 of of IN work_fzrpauvhvnexhintldqhzusndm 32 40 childhood childhood NN work_fzrpauvhvnexhintldqhzusndm 32 41 asthma asthma NN work_fzrpauvhvnexhintldqhzusndm 32 42 and and CC work_fzrpauvhvnexhintldqhzusndm 32 43 allergic allergic JJ work_fzrpauvhvnexhintldqhzusndm 32 44 disorders disorder NNS work_fzrpauvhvnexhintldqhzusndm 32 45 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 32 46 12 12 CD work_fzrpauvhvnexhintldqhzusndm 32 47 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 32 48 . . . work_fzrpauvhvnexhintldqhzusndm 33 1 Accordingly accordingly RB work_fzrpauvhvnexhintldqhzusndm 33 2 , , , work_fzrpauvhvnexhintldqhzusndm 33 3 other other JJ work_fzrpauvhvnexhintldqhzusndm 33 4 studies study NNS work_fzrpauvhvnexhintldqhzusndm 33 5 have have VBP work_fzrpauvhvnexhintldqhzusndm 33 6 also also RB work_fzrpauvhvnexhintldqhzusndm 33 7 reported report VBN work_fzrpauvhvnexhintldqhzusndm 33 8 that that IN work_fzrpauvhvnexhintldqhzusndm 33 9 disruptions disruption NNS work_fzrpauvhvnexhintldqhzusndm 33 10 to to IN work_fzrpauvhvnexhintldqhzusndm 33 11 the the DT work_fzrpauvhvnexhintldqhzusndm 33 12 neonatal neonatal JJ work_fzrpauvhvnexhintldqhzusndm 33 13 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 33 14 is be VBZ work_fzrpauvhvnexhintldqhzusndm 33 15 linked link VBN work_fzrpauvhvnexhintldqhzusndm 33 16 to to IN work_fzrpauvhvnexhintldqhzusndm 33 17 diabetes diabetes NN work_fzrpauvhvnexhintldqhzusndm 33 18 , , , work_fzrpauvhvnexhintldqhzusndm 33 19 asthma asthma NN work_fzrpauvhvnexhintldqhzusndm 33 20 , , , work_fzrpauvhvnexhintldqhzusndm 33 21 necrotizing necrotize VBG work_fzrpauvhvnexhintldqhzusndm 33 22 enterocolitis enterocolitis NN work_fzrpauvhvnexhintldqhzusndm 33 23 , , , work_fzrpauvhvnexhintldqhzusndm 33 24 inflammatory inflammatory JJ work_fzrpauvhvnexhintldqhzusndm 33 25 bowel bowel NN work_fzrpauvhvnexhintldqhzusndm 33 26 disease disease NN work_fzrpauvhvnexhintldqhzusndm 33 27 , , , work_fzrpauvhvnexhintldqhzusndm 33 28 obesity obesity NN work_fzrpauvhvnexhintldqhzusndm 33 29 , , , work_fzrpauvhvnexhintldqhzusndm 33 30 and and CC work_fzrpauvhvnexhintldqhzusndm 33 31 various various JJ work_fzrpauvhvnexhintldqhzusndm 33 32 other other JJ work_fzrpauvhvnexhintldqhzusndm 33 33 inflammatory inflammatory JJ work_fzrpauvhvnexhintldqhzusndm 33 34 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 33 35 , , , work_fzrpauvhvnexhintldqhzusndm 33 36 as as IN work_fzrpauvhvnexhintldqhzusndm 33 37 recently recently RB work_fzrpauvhvnexhintldqhzusndm 33 38 reviewed review VBN work_fzrpauvhvnexhintldqhzusndm 33 39 by by IN work_fzrpauvhvnexhintldqhzusndm 33 40 Amenyogbe Amenyogbe NNP work_fzrpauvhvnexhintldqhzusndm 33 41 et et NNP work_fzrpauvhvnexhintldqhzusndm 33 42 al al NNP work_fzrpauvhvnexhintldqhzusndm 33 43 . . . work_fzrpauvhvnexhintldqhzusndm 34 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 34 2 13 13 CD work_fzrpauvhvnexhintldqhzusndm 34 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 34 4 . . . work_fzrpauvhvnexhintldqhzusndm 35 1 In in IN work_fzrpauvhvnexhintldqhzusndm 35 2 addition addition NN work_fzrpauvhvnexhintldqhzusndm 35 3 to to IN work_fzrpauvhvnexhintldqhzusndm 35 4 the the DT work_fzrpauvhvnexhintldqhzusndm 35 5 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 35 6 , , , work_fzrpauvhvnexhintldqhzusndm 35 7 other other JJ work_fzrpauvhvnexhintldqhzusndm 35 8 exposures exposure NNS work_fzrpauvhvnexhintldqhzusndm 35 9 that that WDT work_fzrpauvhvnexhintldqhzusndm 35 10 also also RB work_fzrpauvhvnexhintldqhzusndm 35 11 constitute constitute VBP work_fzrpauvhvnexhintldqhzusndm 35 12 poor poor JJ work_fzrpauvhvnexhintldqhzusndm 35 13 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 35 14 experience experience NN work_fzrpauvhvnexhintldqhzusndm 35 15 operative operative NN work_fzrpauvhvnexhintldqhzusndm 35 16 during during IN work_fzrpauvhvnexhintldqhzusndm 35 17 a a DT work_fzrpauvhvnexhintldqhzusndm 35 18 sensitive sensitive JJ work_fzrpauvhvnexhintldqhzusndm 35 19 window window NN work_fzrpauvhvnexhintldqhzusndm 35 20 of of IN work_fzrpauvhvnexhintldqhzusndm 35 21 early early JJ work_fzrpauvhvnexhintldqhzusndm 35 22 development development NN work_fzrpauvhvnexhintldqhzusndm 35 23 are be VBP work_fzrpauvhvnexhintldqhzusndm 35 24 likely likely JJ work_fzrpauvhvnexhintldqhzusndm 35 25 to to TO work_fzrpauvhvnexhintldqhzusndm 35 26 affect affect VB work_fzrpauvhvnexhintldqhzusndm 35 27 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 35 28 plasticity plasticity NN work_fzrpauvhvnexhintldqhzusndm 35 29 , , , work_fzrpauvhvnexhintldqhzusndm 35 30 causing cause VBG work_fzrpauvhvnexhintldqhzusndm 35 31 the the DT work_fzrpauvhvnexhintldqhzusndm 35 32 induction induction NN work_fzrpauvhvnexhintldqhzusndm 35 33 of of IN work_fzrpauvhvnexhintldqhzusndm 35 34 disease disease NNP work_fzrpauvhvnexhintldqhzusndm 35 35 risk risk NN work_fzrpauvhvnexhintldqhzusndm 35 36 with with IN work_fzrpauvhvnexhintldqhzusndm 35 37 long long JJ work_fzrpauvhvnexhintldqhzusndm 35 38 - - HYPH work_fzrpauvhvnexhintldqhzusndm 35 39 term term NN work_fzrpauvhvnexhintldqhzusndm 35 40 consequences consequence NNS work_fzrpauvhvnexhintldqhzusndm 35 41 for for IN work_fzrpauvhvnexhintldqhzusndm 35 42 health health NN work_fzrpauvhvnexhintldqhzusndm 35 43 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 35 44 14,15 14,15 CD work_fzrpauvhvnexhintldqhzusndm 35 45 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 35 46 . . . work_fzrpauvhvnexhintldqhzusndm 36 1 Changes change NNS work_fzrpauvhvnexhintldqhzusndm 36 2 in in IN work_fzrpauvhvnexhintldqhzusndm 36 3 nutrition nutrition NN work_fzrpauvhvnexhintldqhzusndm 36 4 and and CC work_fzrpauvhvnexhintldqhzusndm 36 5 lifestyles lifestyle NNS work_fzrpauvhvnexhintldqhzusndm 36 6 related relate VBN work_fzrpauvhvnexhintldqhzusndm 36 7 to to IN work_fzrpauvhvnexhintldqhzusndm 36 8 modernization modernization NN work_fzrpauvhvnexhintldqhzusndm 36 9 have have VBP work_fzrpauvhvnexhintldqhzusndm 36 10 dramatically dramatically RB work_fzrpauvhvnexhintldqhzusndm 36 11 altered alter VBN work_fzrpauvhvnexhintldqhzusndm 36 12 parental parental JJ work_fzrpauvhvnexhintldqhzusndm 36 13 factors factor NNS work_fzrpauvhvnexhintldqhzusndm 36 14 like like IN work_fzrpauvhvnexhintldqhzusndm 36 15 age age NN work_fzrpauvhvnexhintldqhzusndm 36 16 at at IN work_fzrpauvhvnexhintldqhzusndm 36 17 conception conception NN work_fzrpauvhvnexhintldqhzusndm 36 18 , , , work_fzrpauvhvnexhintldqhzusndm 36 19 body body NN work_fzrpauvhvnexhintldqhzusndm 36 20 mass mass NN work_fzrpauvhvnexhintldqhzusndm 36 21 at at IN work_fzrpauvhvnexhintldqhzusndm 36 22 conception conception NN work_fzrpauvhvnexhintldqhzusndm 36 23 , , , work_fzrpauvhvnexhintldqhzusndm 36 24 metabolism metabolism NN work_fzrpauvhvnexhintldqhzusndm 36 25 , , , work_fzrpauvhvnexhintldqhzusndm 36 26 and and CC work_fzrpauvhvnexhintldqhzusndm 36 27 stress stress VB work_fzrpauvhvnexhintldqhzusndm 36 28 with with IN work_fzrpauvhvnexhintldqhzusndm 36 29 support support NN work_fzrpauvhvnexhintldqhzusndm 36 30 from from IN work_fzrpauvhvnexhintldqhzusndm 36 31 animal animal NN work_fzrpauvhvnexhintldqhzusndm 36 32 models model NNS work_fzrpauvhvnexhintldqhzusndm 36 33 and and CC work_fzrpauvhvnexhintldqhzusndm 36 34 human human JJ work_fzrpauvhvnexhintldqhzusndm 36 35 studies study NNS work_fzrpauvhvnexhintldqhzusndm 36 36 , , , work_fzrpauvhvnexhintldqhzusndm 36 37 indicating indicate VBG work_fzrpauvhvnexhintldqhzusndm 36 38 these these DT work_fzrpauvhvnexhintldqhzusndm 36 39 factors factor NNS work_fzrpauvhvnexhintldqhzusndm 36 40 induce induce VBP work_fzrpauvhvnexhintldqhzusndm 36 41 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 36 42 programming programming NN work_fzrpauvhvnexhintldqhzusndm 36 43 of of IN work_fzrpauvhvnexhintldqhzusndm 36 44 disease disease NN work_fzrpauvhvnexhintldqhzusndm 36 45 risk risk NN work_fzrpauvhvnexhintldqhzusndm 36 46 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 36 47 16 16 CD work_fzrpauvhvnexhintldqhzusndm 36 48 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 36 49 . . . work_fzrpauvhvnexhintldqhzusndm 37 1 Epigenetic epigenetic JJ work_fzrpauvhvnexhintldqhzusndm 37 2 mechanisms mechanism NNS work_fzrpauvhvnexhintldqhzusndm 37 3 have have VBP work_fzrpauvhvnexhintldqhzusndm 37 4 been be VBN work_fzrpauvhvnexhintldqhzusndm 37 5 proposed propose VBN work_fzrpauvhvnexhintldqhzusndm 37 6 as as IN work_fzrpauvhvnexhintldqhzusndm 37 7 key key JJ work_fzrpauvhvnexhintldqhzusndm 37 8 mediators mediator NNS work_fzrpauvhvnexhintldqhzusndm 37 9 of of IN work_fzrpauvhvnexhintldqhzusndm 37 10 the the DT work_fzrpauvhvnexhintldqhzusndm 37 11 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 37 12 of of IN work_fzrpauvhvnexhintldqhzusndm 37 13 adverse adverse JJ work_fzrpauvhvnexhintldqhzusndm 37 14 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 37 15 experience experience NN work_fzrpauvhvnexhintldqhzusndm 37 16 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 37 17 reviewed review VBN work_fzrpauvhvnexhintldqhzusndm 37 18 in in IN work_fzrpauvhvnexhintldqhzusndm 37 19 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 37 20 16 16 CD work_fzrpauvhvnexhintldqhzusndm 37 21 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 37 22 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 37 23 . . . work_fzrpauvhvnexhintldqhzusndm 38 1 Critically critically RB work_fzrpauvhvnexhintldqhzusndm 38 2 , , , work_fzrpauvhvnexhintldqhzusndm 38 3 at at IN work_fzrpauvhvnexhintldqhzusndm 38 4 the the DT work_fzrpauvhvnexhintldqhzusndm 38 5 earliest early JJS work_fzrpauvhvnexhintldqhzusndm 38 6 stages stage NNS work_fzrpauvhvnexhintldqhzusndm 38 7 of of IN work_fzrpauvhvnexhintldqhzusndm 38 8 reproduction reproduction NN work_fzrpauvhvnexhintldqhzusndm 38 9 , , , work_fzrpauvhvnexhintldqhzusndm 38 10 the the DT work_fzrpauvhvnexhintldqhzusndm 38 11 few few JJ work_fzrpauvhvnexhintldqhzusndm 38 12 cells cell NNS work_fzrpauvhvnexhintldqhzusndm 38 13 forming form VBG work_fzrpauvhvnexhintldqhzusndm 38 14 the the DT work_fzrpauvhvnexhintldqhzusndm 38 15 conceptus conceptus NN work_fzrpauvhvnexhintldqhzusndm 38 16 are be VBP work_fzrpauvhvnexhintldqhzusndm 38 17 fully fully RB work_fzrpauvhvnexhintldqhzusndm 38 18 exposed expose VBN work_fzrpauvhvnexhintldqhzusndm 38 19 to to IN work_fzrpauvhvnexhintldqhzusndm 38 20 conditions condition NNS work_fzrpauvhvnexhintldqhzusndm 38 21 that that WDT work_fzrpauvhvnexhintldqhzusndm 38 22 disturb disturb VBP work_fzrpauvhvnexhintldqhzusndm 38 23 epigenetic epigenetic JJ work_fzrpauvhvnexhintldqhzusndm 38 24 mechanisms mechanism NNS work_fzrpauvhvnexhintldqhzusndm 38 25 , , , work_fzrpauvhvnexhintldqhzusndm 38 26 leading lead VBG work_fzrpauvhvnexhintldqhzusndm 38 27 to to IN work_fzrpauvhvnexhintldqhzusndm 38 28 persistent persistent JJ work_fzrpauvhvnexhintldqhzusndm 38 29 alterations alteration NNS work_fzrpauvhvnexhintldqhzusndm 38 30 in in IN work_fzrpauvhvnexhintldqhzusndm 38 31 embryonic embryonic JJ work_fzrpauvhvnexhintldqhzusndm 38 32 gene gene NN work_fzrpauvhvnexhintldqhzusndm 38 33 expression expression NN work_fzrpauvhvnexhintldqhzusndm 38 34 that that WDT work_fzrpauvhvnexhintldqhzusndm 38 35 are be VBP work_fzrpauvhvnexhintldqhzusndm 38 36 heritable heritable JJ work_fzrpauvhvnexhintldqhzusndm 38 37 across across IN work_fzrpauvhvnexhintldqhzusndm 38 38 cell cell NN work_fzrpauvhvnexhintldqhzusndm 38 39 divisions division NNS work_fzrpauvhvnexhintldqhzusndm 38 40 and and CC work_fzrpauvhvnexhintldqhzusndm 38 41 alter alter VB work_fzrpauvhvnexhintldqhzusndm 38 42 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 38 43 trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 38 44 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 38 45 15 15 CD work_fzrpauvhvnexhintldqhzusndm 38 46 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 38 47 . . . work_fzrpauvhvnexhintldqhzusndm 39 1 These these DT work_fzrpauvhvnexhintldqhzusndm 39 2 mechanisms mechanism NNS work_fzrpauvhvnexhintldqhzusndm 39 3 have have VBP work_fzrpauvhvnexhintldqhzusndm 39 4 been be VBN work_fzrpauvhvnexhintldqhzusndm 39 5 proposed propose VBN work_fzrpauvhvnexhintldqhzusndm 39 6 as as IN work_fzrpauvhvnexhintldqhzusndm 39 7 exponents exponent NNS work_fzrpauvhvnexhintldqhzusndm 39 8 of of IN work_fzrpauvhvnexhintldqhzusndm 39 9 rapidly rapidly RB work_fzrpauvhvnexhintldqhzusndm 39 10 rising rise VBG work_fzrpauvhvnexhintldqhzusndm 39 11 community community NN work_fzrpauvhvnexhintldqhzusndm 39 12 rates rate NNS work_fzrpauvhvnexhintldqhzusndm 39 13 of of IN work_fzrpauvhvnexhintldqhzusndm 39 14 NCDs NCDs NNPS work_fzrpauvhvnexhintldqhzusndm 39 15 independently independently RB work_fzrpauvhvnexhintldqhzusndm 39 16 of of IN work_fzrpauvhvnexhintldqhzusndm 39 17 genetic genetic JJ work_fzrpauvhvnexhintldqhzusndm 39 18 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 39 19 . . . work_fzrpauvhvnexhintldqhzusndm 40 1 3 3 LS work_fzrpauvhvnexhintldqhzusndm 40 2 . . . work_fzrpauvhvnexhintldqhzusndm 41 1 Moving move VBG work_fzrpauvhvnexhintldqhzusndm 41 2 beyond beyond IN work_fzrpauvhvnexhintldqhzusndm 41 3 Reductionist Reductionist NNP work_fzrpauvhvnexhintldqhzusndm 41 4 Biology Biology NNP work_fzrpauvhvnexhintldqhzusndm 41 5 : : : work_fzrpauvhvnexhintldqhzusndm 41 6 Systems system NNS work_fzrpauvhvnexhintldqhzusndm 41 7 - - HYPH work_fzrpauvhvnexhintldqhzusndm 41 8 Level level NN work_fzrpauvhvnexhintldqhzusndm 41 9 Understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 41 10 of of IN work_fzrpauvhvnexhintldqhzusndm 41 11 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 41 12 Dysregulation Dysregulation NNP work_fzrpauvhvnexhintldqhzusndm 41 13 Elucidation Elucidation NNP work_fzrpauvhvnexhintldqhzusndm 41 14 of of IN work_fzrpauvhvnexhintldqhzusndm 41 15 the the DT work_fzrpauvhvnexhintldqhzusndm 41 16 mechanisms mechanism NNS work_fzrpauvhvnexhintldqhzusndm 41 17 underlying underlie VBG work_fzrpauvhvnexhintldqhzusndm 41 18 perinatal perinatal JJ work_fzrpauvhvnexhintldqhzusndm 41 19 induction induction NN work_fzrpauvhvnexhintldqhzusndm 41 20 of of IN work_fzrpauvhvnexhintldqhzusndm 41 21 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 41 22 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 41 23 will will MD work_fzrpauvhvnexhintldqhzusndm 41 24 be be VB work_fzrpauvhvnexhintldqhzusndm 41 25 extremely extremely RB work_fzrpauvhvnexhintldqhzusndm 41 26 challenging challenging JJ work_fzrpauvhvnexhintldqhzusndm 41 27 because because IN work_fzrpauvhvnexhintldqhzusndm 41 28 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 41 29 phenotypes phenotype NNS work_fzrpauvhvnexhintldqhzusndm 41 30 are be VBP work_fzrpauvhvnexhintldqhzusndm 41 31 emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 41 32 properties property NNS work_fzrpauvhvnexhintldqhzusndm 41 33 of of IN work_fzrpauvhvnexhintldqhzusndm 41 34 highly highly RB work_fzrpauvhvnexhintldqhzusndm 41 35 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 41 36 Challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 41 37 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 41 38 , , , work_fzrpauvhvnexhintldqhzusndm 41 39 10 10 CD work_fzrpauvhvnexhintldqhzusndm 41 40 , , , work_fzrpauvhvnexhintldqhzusndm 41 41 23 23 CD work_fzrpauvhvnexhintldqhzusndm 41 42 3 3 CD work_fzrpauvhvnexhintldqhzusndm 41 43 of of IN work_fzrpauvhvnexhintldqhzusndm 41 44 9 9 CD work_fzrpauvhvnexhintldqhzusndm 41 45 and and CC work_fzrpauvhvnexhintldqhzusndm 41 46 dynamic dynamic JJ work_fzrpauvhvnexhintldqhzusndm 41 47 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 41 48 between between IN work_fzrpauvhvnexhintldqhzusndm 41 49 a a DT work_fzrpauvhvnexhintldqhzusndm 41 50 large large JJ work_fzrpauvhvnexhintldqhzusndm 41 51 number number NN work_fzrpauvhvnexhintldqhzusndm 41 52 of of IN work_fzrpauvhvnexhintldqhzusndm 41 53 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 41 54 components component NNS work_fzrpauvhvnexhintldqhzusndm 41 55 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 41 56 17 17 CD work_fzrpauvhvnexhintldqhzusndm 41 57 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 41 58 . . . work_fzrpauvhvnexhintldqhzusndm 42 1 The the DT work_fzrpauvhvnexhintldqhzusndm 42 2 advent advent NN work_fzrpauvhvnexhintldqhzusndm 42 3 of of IN work_fzrpauvhvnexhintldqhzusndm 42 4 high high JJ work_fzrpauvhvnexhintldqhzusndm 42 5 - - HYPH work_fzrpauvhvnexhintldqhzusndm 42 6 throughput throughput NN work_fzrpauvhvnexhintldqhzusndm 42 7 sequencing sequencing NN work_fzrpauvhvnexhintldqhzusndm 42 8 and and CC work_fzrpauvhvnexhintldqhzusndm 42 9 mass mass NN work_fzrpauvhvnexhintldqhzusndm 42 10 spectrometry spectrometry NN work_fzrpauvhvnexhintldqhzusndm 42 11 now now RB work_fzrpauvhvnexhintldqhzusndm 42 12 enables enable VBZ work_fzrpauvhvnexhintldqhzusndm 42 13 the the DT work_fzrpauvhvnexhintldqhzusndm 42 14 profiling profiling NN work_fzrpauvhvnexhintldqhzusndm 42 15 of of IN work_fzrpauvhvnexhintldqhzusndm 42 16 these these DT work_fzrpauvhvnexhintldqhzusndm 42 17 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 42 18 components component NNS work_fzrpauvhvnexhintldqhzusndm 42 19 across across IN work_fzrpauvhvnexhintldqhzusndm 42 20 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 42 21 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 42 22 of of IN work_fzrpauvhvnexhintldqhzusndm 42 23 regulation regulation NN work_fzrpauvhvnexhintldqhzusndm 42 24 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 42 25 genome genome JJ work_fzrpauvhvnexhintldqhzusndm 42 26 , , , work_fzrpauvhvnexhintldqhzusndm 42 27 epigenome epigenome NN work_fzrpauvhvnexhintldqhzusndm 42 28 , , , work_fzrpauvhvnexhintldqhzusndm 42 29 transcriptome transcriptome NNP work_fzrpauvhvnexhintldqhzusndm 42 30 , , , work_fzrpauvhvnexhintldqhzusndm 42 31 proteome proteome NN work_fzrpauvhvnexhintldqhzusndm 42 32 , , , work_fzrpauvhvnexhintldqhzusndm 42 33 metabolome metabolome NN work_fzrpauvhvnexhintldqhzusndm 42 34 , , , work_fzrpauvhvnexhintldqhzusndm 42 35 and and CC work_fzrpauvhvnexhintldqhzusndm 42 36 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 42 37 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 42 38 . . . work_fzrpauvhvnexhintldqhzusndm 43 1 These these DT work_fzrpauvhvnexhintldqhzusndm 43 2 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 43 3 technologies technology NNS work_fzrpauvhvnexhintldqhzusndm 43 4 have have VBP work_fzrpauvhvnexhintldqhzusndm 43 5 proven prove VBN work_fzrpauvhvnexhintldqhzusndm 43 6 invaluable invaluable JJ work_fzrpauvhvnexhintldqhzusndm 43 7 for for IN work_fzrpauvhvnexhintldqhzusndm 43 8 enhancing enhance VBG work_fzrpauvhvnexhintldqhzusndm 43 9 our -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 43 10 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 43 11 of of IN work_fzrpauvhvnexhintldqhzusndm 43 12 the the DT work_fzrpauvhvnexhintldqhzusndm 43 13 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 43 14 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 43 15 of of IN work_fzrpauvhvnexhintldqhzusndm 43 16 regulation regulation NN work_fzrpauvhvnexhintldqhzusndm 43 17 , , , work_fzrpauvhvnexhintldqhzusndm 43 18 however however RB work_fzrpauvhvnexhintldqhzusndm 43 19 , , , work_fzrpauvhvnexhintldqhzusndm 43 20 efforts effort NNS work_fzrpauvhvnexhintldqhzusndm 43 21 are be VBP work_fzrpauvhvnexhintldqhzusndm 43 22 underway underway JJ work_fzrpauvhvnexhintldqhzusndm 43 23 to to TO work_fzrpauvhvnexhintldqhzusndm 43 24 combine combine VB work_fzrpauvhvnexhintldqhzusndm 43 25 these these DT work_fzrpauvhvnexhintldqhzusndm 43 26 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 43 27 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 43 28 into into IN work_fzrpauvhvnexhintldqhzusndm 43 29 a a DT work_fzrpauvhvnexhintldqhzusndm 43 30 more more RBR work_fzrpauvhvnexhintldqhzusndm 43 31 comprehensive comprehensive JJ work_fzrpauvhvnexhintldqhzusndm 43 32 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 43 33 view view NN work_fzrpauvhvnexhintldqhzusndm 43 34 of of IN work_fzrpauvhvnexhintldqhzusndm 43 35 the the DT work_fzrpauvhvnexhintldqhzusndm 43 36 entire entire JJ work_fzrpauvhvnexhintldqhzusndm 43 37 system system NN work_fzrpauvhvnexhintldqhzusndm 43 38 . . . work_fzrpauvhvnexhintldqhzusndm 44 1 Parallel parallel JJ work_fzrpauvhvnexhintldqhzusndm 44 2 initiatives initiative NNS work_fzrpauvhvnexhintldqhzusndm 44 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 44 4 underway underway JJ work_fzrpauvhvnexhintldqhzusndm 44 5 to to TO work_fzrpauvhvnexhintldqhzusndm 44 6 develop develop VB work_fzrpauvhvnexhintldqhzusndm 44 7 the the DT work_fzrpauvhvnexhintldqhzusndm 44 8 tools tool NNS work_fzrpauvhvnexhintldqhzusndm 44 9 to to IN work_fzrpauvhvnexhintldqhzusndm 44 10 more more RBR work_fzrpauvhvnexhintldqhzusndm 44 11 comprehensively comprehensively RB work_fzrpauvhvnexhintldqhzusndm 44 12 measure measure VB work_fzrpauvhvnexhintldqhzusndm 44 13 the the DT work_fzrpauvhvnexhintldqhzusndm 44 14 exposome exposome NN work_fzrpauvhvnexhintldqhzusndm 44 15 , , , work_fzrpauvhvnexhintldqhzusndm 44 16 which which WDT work_fzrpauvhvnexhintldqhzusndm 44 17 encompasses encompass VBZ work_fzrpauvhvnexhintldqhzusndm 44 18 the the DT work_fzrpauvhvnexhintldqhzusndm 44 19 totality totality NN work_fzrpauvhvnexhintldqhzusndm 44 20 of of IN work_fzrpauvhvnexhintldqhzusndm 44 21 the the DT work_fzrpauvhvnexhintldqhzusndm 44 22 environmental environmental JJ work_fzrpauvhvnexhintldqhzusndm 44 23 exposures exposure NNS work_fzrpauvhvnexhintldqhzusndm 44 24 encountered encounter VBN work_fzrpauvhvnexhintldqhzusndm 44 25 by by IN work_fzrpauvhvnexhintldqhzusndm 44 26 an an DT work_fzrpauvhvnexhintldqhzusndm 44 27 individual individual NN work_fzrpauvhvnexhintldqhzusndm 44 28 over over IN work_fzrpauvhvnexhintldqhzusndm 44 29 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 44 30 life life NN work_fzrpauvhvnexhintldqhzusndm 44 31 course course NN work_fzrpauvhvnexhintldqhzusndm 44 32 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 44 33 18,19 18,19 CD work_fzrpauvhvnexhintldqhzusndm 44 34 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 44 35 . . . work_fzrpauvhvnexhintldqhzusndm 45 1 We -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 45 2 anticipate anticipate VBP work_fzrpauvhvnexhintldqhzusndm 45 3 that that IN work_fzrpauvhvnexhintldqhzusndm 45 4 incorporation incorporation NN work_fzrpauvhvnexhintldqhzusndm 45 5 of of IN work_fzrpauvhvnexhintldqhzusndm 45 6 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 45 7 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 45 8 data datum NNS work_fzrpauvhvnexhintldqhzusndm 45 9 into into IN work_fzrpauvhvnexhintldqhzusndm 45 10 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 45 11 space space NN work_fzrpauvhvnexhintldqhzusndm 45 12 in in IN work_fzrpauvhvnexhintldqhzusndm 45 13 combination combination NN work_fzrpauvhvnexhintldqhzusndm 45 14 with with IN work_fzrpauvhvnexhintldqhzusndm 45 15 the the DT work_fzrpauvhvnexhintldqhzusndm 45 16 exposome exposome NN work_fzrpauvhvnexhintldqhzusndm 45 17 will will MD work_fzrpauvhvnexhintldqhzusndm 45 18 enable enable VB work_fzrpauvhvnexhintldqhzusndm 45 19 a a DT work_fzrpauvhvnexhintldqhzusndm 45 20 greater great JJR work_fzrpauvhvnexhintldqhzusndm 45 21 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 45 22 of of IN work_fzrpauvhvnexhintldqhzusndm 45 23 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 45 24 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 45 25 systems system NNS work_fzrpauvhvnexhintldqhzusndm 45 26 . . . work_fzrpauvhvnexhintldqhzusndm 46 1 These these DT work_fzrpauvhvnexhintldqhzusndm 46 2 systems system NNS work_fzrpauvhvnexhintldqhzusndm 46 3 biology biology NN work_fzrpauvhvnexhintldqhzusndm 46 4 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 46 5 will will MD work_fzrpauvhvnexhintldqhzusndm 46 6 be be VB work_fzrpauvhvnexhintldqhzusndm 46 7 necessary necessary JJ work_fzrpauvhvnexhintldqhzusndm 46 8 in in IN work_fzrpauvhvnexhintldqhzusndm 46 9 order order NN work_fzrpauvhvnexhintldqhzusndm 46 10 to to TO work_fzrpauvhvnexhintldqhzusndm 46 11 make make VB work_fzrpauvhvnexhintldqhzusndm 46 12 sense sense NN work_fzrpauvhvnexhintldqhzusndm 46 13 of of IN work_fzrpauvhvnexhintldqhzusndm 46 14 the the DT work_fzrpauvhvnexhintldqhzusndm 46 15 complexity complexity NN work_fzrpauvhvnexhintldqhzusndm 46 16 of of IN work_fzrpauvhvnexhintldqhzusndm 46 17 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 46 18 that that WDT work_fzrpauvhvnexhintldqhzusndm 46 19 govern govern VBP work_fzrpauvhvnexhintldqhzusndm 46 20 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 46 21 development development NN work_fzrpauvhvnexhintldqhzusndm 46 22 and and CC work_fzrpauvhvnexhintldqhzusndm 46 23 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 46 24 . . . work_fzrpauvhvnexhintldqhzusndm 47 1 Systems system NNS work_fzrpauvhvnexhintldqhzusndm 47 2 biology biology NN work_fzrpauvhvnexhintldqhzusndm 47 3 begins begin VBZ work_fzrpauvhvnexhintldqhzusndm 47 4 with with IN work_fzrpauvhvnexhintldqhzusndm 47 5 the the DT work_fzrpauvhvnexhintldqhzusndm 47 6 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 47 7 that that IN work_fzrpauvhvnexhintldqhzusndm 47 8 cellular cellular JJ work_fzrpauvhvnexhintldqhzusndm 47 9 behavior behavior NN work_fzrpauvhvnexhintldqhzusndm 47 10 and and CC work_fzrpauvhvnexhintldqhzusndm 47 11 function function NN work_fzrpauvhvnexhintldqhzusndm 47 12 are be VBP work_fzrpauvhvnexhintldqhzusndm 47 13 emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 47 14 properties property NNS work_fzrpauvhvnexhintldqhzusndm 47 15 of of IN work_fzrpauvhvnexhintldqhzusndm 47 16 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 47 17 and and CC work_fzrpauvhvnexhintldqhzusndm 47 18 dynamic dynamic JJ work_fzrpauvhvnexhintldqhzusndm 47 19 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 47 20 between between IN work_fzrpauvhvnexhintldqhzusndm 47 21 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 47 22 and and CC work_fzrpauvhvnexhintldqhzusndm 47 23 biomolecules biomolecule NNS work_fzrpauvhvnexhintldqhzusndm 47 24 . . . work_fzrpauvhvnexhintldqhzusndm 48 1 Emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 48 2 properties property NNS work_fzrpauvhvnexhintldqhzusndm 48 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 48 4 characteristics characteristic NNS work_fzrpauvhvnexhintldqhzusndm 48 5 of of IN work_fzrpauvhvnexhintldqhzusndm 48 6 the the DT work_fzrpauvhvnexhintldqhzusndm 48 7 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 48 8 system system NN work_fzrpauvhvnexhintldqhzusndm 48 9 that that WDT work_fzrpauvhvnexhintldqhzusndm 48 10 are be VBP work_fzrpauvhvnexhintldqhzusndm 48 11 not not RB work_fzrpauvhvnexhintldqhzusndm 48 12 present present JJ work_fzrpauvhvnexhintldqhzusndm 48 13 in in IN work_fzrpauvhvnexhintldqhzusndm 48 14 the the DT work_fzrpauvhvnexhintldqhzusndm 48 15 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 48 16 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 48 17 components component NNS work_fzrpauvhvnexhintldqhzusndm 48 18 and and CC work_fzrpauvhvnexhintldqhzusndm 48 19 , , , work_fzrpauvhvnexhintldqhzusndm 48 20 hence hence RB work_fzrpauvhvnexhintldqhzusndm 48 21 , , , work_fzrpauvhvnexhintldqhzusndm 48 22 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 48 23 systems system NNS work_fzrpauvhvnexhintldqhzusndm 48 24 are be VBP work_fzrpauvhvnexhintldqhzusndm 48 25 more more JJR work_fzrpauvhvnexhintldqhzusndm 48 26 than than IN work_fzrpauvhvnexhintldqhzusndm 48 27 the the DT work_fzrpauvhvnexhintldqhzusndm 48 28 sum sum NN work_fzrpauvhvnexhintldqhzusndm 48 29 of of IN work_fzrpauvhvnexhintldqhzusndm 48 30 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 48 31 parts part NNS work_fzrpauvhvnexhintldqhzusndm 48 32 . . . work_fzrpauvhvnexhintldqhzusndm 49 1 The the DT work_fzrpauvhvnexhintldqhzusndm 49 2 application application NN work_fzrpauvhvnexhintldqhzusndm 49 3 of of IN work_fzrpauvhvnexhintldqhzusndm 49 4 network network NN work_fzrpauvhvnexhintldqhzusndm 49 5 graph graph NN work_fzrpauvhvnexhintldqhzusndm 49 6 theory theory NN work_fzrpauvhvnexhintldqhzusndm 49 7 to to IN work_fzrpauvhvnexhintldqhzusndm 49 8 the the DT work_fzrpauvhvnexhintldqhzusndm 49 9 study study NN work_fzrpauvhvnexhintldqhzusndm 49 10 of of IN work_fzrpauvhvnexhintldqhzusndm 49 11 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 49 12 systems system NNS work_fzrpauvhvnexhintldqhzusndm 49 13 has have VBZ work_fzrpauvhvnexhintldqhzusndm 49 14 revealed reveal VBN work_fzrpauvhvnexhintldqhzusndm 49 15 that that IN work_fzrpauvhvnexhintldqhzusndm 49 16 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 49 17 systems system NNS work_fzrpauvhvnexhintldqhzusndm 49 18 are be VBP work_fzrpauvhvnexhintldqhzusndm 49 19 governed govern VBN work_fzrpauvhvnexhintldqhzusndm 49 20 by by IN work_fzrpauvhvnexhintldqhzusndm 49 21 a a DT work_fzrpauvhvnexhintldqhzusndm 49 22 set set NN work_fzrpauvhvnexhintldqhzusndm 49 23 of of IN work_fzrpauvhvnexhintldqhzusndm 49 24 universal universal JJ work_fzrpauvhvnexhintldqhzusndm 49 25 organizing organizing NN work_fzrpauvhvnexhintldqhzusndm 49 26 principles principle NNS work_fzrpauvhvnexhintldqhzusndm 49 27 , , , work_fzrpauvhvnexhintldqhzusndm 49 28 or or CC work_fzrpauvhvnexhintldqhzusndm 49 29 common common JJ work_fzrpauvhvnexhintldqhzusndm 49 30 design design NN work_fzrpauvhvnexhintldqhzusndm 49 31 elements element NNS work_fzrpauvhvnexhintldqhzusndm 49 32 that that WDT work_fzrpauvhvnexhintldqhzusndm 49 33 can can MD work_fzrpauvhvnexhintldqhzusndm 49 34 also also RB work_fzrpauvhvnexhintldqhzusndm 49 35 be be VB work_fzrpauvhvnexhintldqhzusndm 49 36 observed observe VBN work_fzrpauvhvnexhintldqhzusndm 49 37 in in IN work_fzrpauvhvnexhintldqhzusndm 49 38 man man NN work_fzrpauvhvnexhintldqhzusndm 49 39 - - HYPH work_fzrpauvhvnexhintldqhzusndm 49 40 made make VBN work_fzrpauvhvnexhintldqhzusndm 49 41 systems system NNS work_fzrpauvhvnexhintldqhzusndm 49 42 , , , work_fzrpauvhvnexhintldqhzusndm 49 43 such such JJ work_fzrpauvhvnexhintldqhzusndm 49 44 as as IN work_fzrpauvhvnexhintldqhzusndm 49 45 power power NN work_fzrpauvhvnexhintldqhzusndm 49 46 grids grid NNS work_fzrpauvhvnexhintldqhzusndm 49 47 and and CC work_fzrpauvhvnexhintldqhzusndm 49 48 the the DT work_fzrpauvhvnexhintldqhzusndm 49 49 world world NN work_fzrpauvhvnexhintldqhzusndm 49 50 wide wide JJ work_fzrpauvhvnexhintldqhzusndm 49 51 web web NN work_fzrpauvhvnexhintldqhzusndm 49 52 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 49 53 20 20 CD work_fzrpauvhvnexhintldqhzusndm 49 54 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 49 55 . . . work_fzrpauvhvnexhintldqhzusndm 50 1 Complex complex JJ work_fzrpauvhvnexhintldqhzusndm 50 2 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 50 3 systems system NNS work_fzrpauvhvnexhintldqhzusndm 50 4 have have VBP work_fzrpauvhvnexhintldqhzusndm 50 5 a a DT work_fzrpauvhvnexhintldqhzusndm 50 6 scale scale NN work_fzrpauvhvnexhintldqhzusndm 50 7 - - HYPH work_fzrpauvhvnexhintldqhzusndm 50 8 free free JJ work_fzrpauvhvnexhintldqhzusndm 50 9 architecture architecture NN work_fzrpauvhvnexhintldqhzusndm 50 10 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 50 11 Figure Figure NNP work_fzrpauvhvnexhintldqhzusndm 50 12 1 1 CD work_fzrpauvhvnexhintldqhzusndm 50 13 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 50 14 , , , work_fzrpauvhvnexhintldqhzusndm 50 15 where where WRB work_fzrpauvhvnexhintldqhzusndm 50 16 most most JJS work_fzrpauvhvnexhintldqhzusndm 50 17 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 50 18 are be VBP work_fzrpauvhvnexhintldqhzusndm 50 19 interlinked interlink VBN work_fzrpauvhvnexhintldqhzusndm 50 20 with with IN work_fzrpauvhvnexhintldqhzusndm 50 21 a a DT work_fzrpauvhvnexhintldqhzusndm 50 22 few few JJ work_fzrpauvhvnexhintldqhzusndm 50 23 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 50 24 , , , work_fzrpauvhvnexhintldqhzusndm 50 25 and and CC work_fzrpauvhvnexhintldqhzusndm 50 26 a a DT work_fzrpauvhvnexhintldqhzusndm 50 27 few few JJ work_fzrpauvhvnexhintldqhzusndm 50 28 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 50 29 interact interact VBP work_fzrpauvhvnexhintldqhzusndm 50 30 with with IN work_fzrpauvhvnexhintldqhzusndm 50 31 many many JJ work_fzrpauvhvnexhintldqhzusndm 50 32 , , , work_fzrpauvhvnexhintldqhzusndm 50 33 giving give VBG work_fzrpauvhvnexhintldqhzusndm 50 34 rise rise NN work_fzrpauvhvnexhintldqhzusndm 50 35 to to IN work_fzrpauvhvnexhintldqhzusndm 50 36 hubs hubs VB work_fzrpauvhvnexhintldqhzusndm 50 37 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 50 38 21–23 21–23 NN work_fzrpauvhvnexhintldqhzusndm 50 39 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 50 40 . . . work_fzrpauvhvnexhintldqhzusndm 51 1 Challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 51 2 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 51 3 , , , work_fzrpauvhvnexhintldqhzusndm 51 4 10 10 CD work_fzrpauvhvnexhintldqhzusndm 51 5 3 3 CD work_fzrpauvhvnexhintldqhzusndm 51 6 Elucidation elucidation NN work_fzrpauvhvnexhintldqhzusndm 51 7 of of IN work_fzrpauvhvnexhintldqhzusndm 51 8 the the DT work_fzrpauvhvnexhintldqhzusndm 51 9 mechanisms mechanism NNS work_fzrpauvhvnexhintldqhzusndm 51 10 underlying underlie VBG work_fzrpauvhvnexhintldqhzusndm 51 11 perinatal perinatal JJ work_fzrpauvhvnexhintldqhzusndm 51 12 induction induction NN work_fzrpauvhvnexhintldqhzusndm 51 13 of of IN work_fzrpauvhvnexhintldqhzusndm 51 14 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 51 15 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 51 16 will will MD work_fzrpauvhvnexhintldqhzusndm 51 17 be be VB work_fzrpauvhvnexhintldqhzusndm 51 18 extremely extremely RB work_fzrpauvhvnexhintldqhzusndm 51 19 challenging challenging JJ work_fzrpauvhvnexhintldqhzusndm 51 20 because because IN work_fzrpauvhvnexhintldqhzusndm 51 21 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 51 22 phenotypes phenotype NNS work_fzrpauvhvnexhintldqhzusndm 51 23 are be VBP work_fzrpauvhvnexhintldqhzusndm 51 24 emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 51 25 properties property NNS work_fzrpauvhvnexhintldqhzusndm 51 26 of of IN work_fzrpauvhvnexhintldqhzusndm 51 27 highly highly RB work_fzrpauvhvnexhintldqhzusndm 51 28 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 51 29 and and CC work_fzrpauvhvnexhintldqhzusndm 51 30 dynamic dynamic JJ work_fzrpauvhvnexhintldqhzusndm 51 31 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 51 32 between between IN work_fzrpauvhvnexhintldqhzusndm 51 33 a a DT work_fzrpauvhvnexhintldqhzusndm 51 34 large large JJ work_fzrpauvhvnexhintldqhzusndm 51 35 number number NN work_fzrpauvhvnexhintldqhzusndm 51 36 of of IN work_fzrpauvhvnexhintldqhzusndm 51 37 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 51 38 components component NNS work_fzrpauvhvnexhintldqhzusndm 51 39 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 51 40 17 17 CD work_fzrpauvhvnexhintldqhzusndm 51 41 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 51 42 . . . work_fzrpauvhvnexhintldqhzusndm 52 1 The the DT work_fzrpauvhvnexhintldqhzusndm 52 2 advent advent NN work_fzrpauvhvnexhintldqhzusndm 52 3 of of IN work_fzrpauvhvnexhintldqhzusndm 52 4 high- high- JJ work_fzrpauvhvnexhintldqhzusndm 52 5 throughput throughput NN work_fzrpauvhvnexhintldqhzusndm 52 6 sequencing sequencing NN work_fzrpauvhvnexhintldqhzusndm 52 7 and and CC work_fzrpauvhvnexhintldqhzusndm 52 8 mass mass NN work_fzrpauvhvnexhintldqhzusndm 52 9 spectrometry spectrometry NN work_fzrpauvhvnexhintldqhzusndm 52 10 now now RB work_fzrpauvhvnexhintldqhzusndm 52 11 enables enable VBZ work_fzrpauvhvnexhintldqhzusndm 52 12 the the DT work_fzrpauvhvnexhintldqhzusndm 52 13 profiling profiling NN work_fzrpauvhvnexhintldqhzusndm 52 14 of of IN work_fzrpauvhvnexhintldqhzusndm 52 15 these these DT work_fzrpauvhvnexhintldqhzusndm 52 16 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 52 17 components component NNS work_fzrpauvhvnexhintldqhzusndm 52 18 across across IN work_fzrpauvhvnexhintldqhzusndm 52 19 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 52 20 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 52 21 of of IN work_fzrpauvhvnexhintldqhzusndm 52 22 regulation regulation NN work_fzrpauvhvnexhintldqhzusndm 52 23 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 52 24 genome genome JJ work_fzrpauvhvnexhintldqhzusndm 52 25 , , , work_fzrpauvhvnexhintldqhzusndm 52 26 epigenome epigenome NN work_fzrpauvhvnexhintldqhzusndm 52 27 , , , work_fzrpauvhvnexhintldqhzusndm 52 28 transcriptome transcriptome NNP work_fzrpauvhvnexhintldqhzusndm 52 29 , , , work_fzrpauvhvnexhintldqhzusndm 52 30 proteome proteome NN work_fzrpauvhvnexhintldqhzusndm 52 31 , , , work_fzrpauvhvnexhintldqhzusndm 52 32 metabolome metabolome NN work_fzrpauvhvnexhintldqhzusndm 52 33 , , , work_fzrpauvhvnexhintldqhzusndm 52 34 and and CC work_fzrpauvhvnexhintldqhzusndm 52 35 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 52 36 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 52 37 . . . work_fzrpauvhvnexhintldqhzusndm 53 1 These these DT work_fzrpauvhvnexhintldqhzusndm 53 2 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 53 3 technologies technology NNS work_fzrpauvhvnexhintldqhzusndm 53 4 have have VBP work_fzrpauvhvnexhintldqhzusndm 53 5 proven prove VBN work_fzrpauvhvnexhintldqhzusndm 53 6 invaluable invaluable JJ work_fzrpauvhvnexhintldqhzusndm 53 7 for for IN work_fzrpauvhvnexhintldqhzusndm 53 8 enhancing enhance VBG work_fzrpauvhvnexhintldqhzusndm 53 9 our -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 53 10 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 53 11 of of IN work_fzrpauvhvnexhintldqhzusndm 53 12 the the DT work_fzrpauvhvnexhintldqhzusndm 53 13 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 53 14 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 53 15 of of IN work_fzrpauvhvnexhintldqhzusndm 53 16 regulation regulation NN work_fzrpauvhvnexhintldqhzusndm 53 17 , , , work_fzrpauvhvnexhintldqhzusndm 53 18 however however RB work_fzrpauvhvnexhintldqhzusndm 53 19 , , , work_fzrpauvhvnexhintldqhzusndm 53 20 efforts effort NNS work_fzrpauvhvnexhintldqhzusndm 53 21 are be VBP work_fzrpauvhvnexhintldqhzusndm 53 22 underway underway JJ work_fzrpauvhvnexhintldqhzusndm 53 23 to to TO work_fzrpauvhvnexhintldqhzusndm 53 24 combine combine VB work_fzrpauvhvnexhintldqhzusndm 53 25 these these DT work_fzrpauvhvnexhintldqhzusndm 53 26 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 53 27 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 53 28 into into IN work_fzrpauvhvnexhintldqhzusndm 53 29 a a DT work_fzrpauvhvnexhintldqhzusndm 53 30 more more RBR work_fzrpauvhvnexhintldqhzusndm 53 31 comprehensive comprehensive JJ work_fzrpauvhvnexhintldqhzusndm 53 32 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 53 33 view view NN work_fzrpauvhvnexhintldqhzusndm 53 34 of of IN work_fzrpauvhvnexhintldqhzusndm 53 35 the the DT work_fzrpauvhvnexhintldqhzusndm 53 36 entire entire JJ work_fzrpauvhvnexhintldqhzusndm 53 37 system system NN work_fzrpauvhvnexhintldqhzusndm 53 38 . . . work_fzrpauvhvnexhintldqhzusndm 54 1 Parallel parallel JJ work_fzrpauvhvnexhintldqhzusndm 54 2 initiatives initiative NNS work_fzrpauvhvnexhintldqhzusndm 54 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 54 4 underway underway JJ work_fzrpauvhvnexhintldqhzusndm 54 5 to to TO work_fzrpauvhvnexhintldqhzusndm 54 6 develop develop VB work_fzrpauvhvnexhintldqhzusndm 54 7 the the DT work_fzrpauvhvnexhintldqhzusndm 54 8 tools tool NNS work_fzrpauvhvnexhintldqhzusndm 54 9 to to IN work_fzrpauvhvnexhintldqhzusndm 54 10 more more RBR work_fzrpauvhvnexhintldqhzusndm 54 11 comprehensively comprehensively RB work_fzrpauvhvnexhintldqhzusndm 54 12 measure measure VB work_fzrpauvhvnexhintldqhzusndm 54 13 the the DT work_fzrpauvhvnexhintldqhzusndm 54 14 exposome exposome NN work_fzrpauvhvnexhintldqhzusndm 54 15 , , , work_fzrpauvhvnexhintldqhzusndm 54 16 which which WDT work_fzrpauvhvnexhintldqhzusndm 54 17 encompasses encompass VBZ work_fzrpauvhvnexhintldqhzusndm 54 18 the the DT work_fzrpauvhvnexhintldqhzusndm 54 19 totality totality NN work_fzrpauvhvnexhintldqhzusndm 54 20 of of IN work_fzrpauvhvnexhintldqhzusndm 54 21 the the DT work_fzrpauvhvnexhintldqhzusndm 54 22 environmental environmental JJ work_fzrpauvhvnexhintldqhzusndm 54 23 exposures exposure NNS work_fzrpauvhvnexhintldqhzusndm 54 24 encountered encounter VBN work_fzrpauvhvnexhintldqhzusndm 54 25 by by IN work_fzrpauvhvnexhintldqhzusndm 54 26 an an DT work_fzrpauvhvnexhintldqhzusndm 54 27 individual individual NN work_fzrpauvhvnexhintldqhzusndm 54 28 over over IN work_fzrpauvhvnexhintldqhzusndm 54 29 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 54 30 life life NN work_fzrpauvhvnexhintldqhzusndm 54 31 course course NN work_fzrpauvhvnexhintldqhzusndm 54 32 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 54 33 18,19 18,19 CD work_fzrpauvhvnexhintldqhzusndm 54 34 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 54 35 . . . work_fzrpauvhvnexhintldqhzusndm 55 1 We -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 55 2 anticipate anticipate VBP work_fzrpauvhvnexhintldqhzusndm 55 3 that that IN work_fzrpauvhvnexhintldqhzusndm 55 4 incorporation incorporation NN work_fzrpauvhvnexhintldqhzusndm 55 5 of of IN work_fzrpauvhvnexhintldqhzusndm 55 6 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 55 7 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 55 8 data datum NNS work_fzrpauvhvnexhintldqhzusndm 55 9 into into IN work_fzrpauvhvnexhintldqhzusndm 55 10 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 55 11 space space NN work_fzrpauvhvnexhintldqhzusndm 55 12 in in IN work_fzrpauvhvnexhintldqhzusndm 55 13 combination combination NN work_fzrpauvhvnexhintldqhzusndm 55 14 with with IN work_fzrpauvhvnexhintldqhzusndm 55 15 the the DT work_fzrpauvhvnexhintldqhzusndm 55 16 exposome exposome NN work_fzrpauvhvnexhintldqhzusndm 55 17 will will MD work_fzrpauvhvnexhintldqhzusndm 55 18 enable enable VB work_fzrpauvhvnexhintldqhzusndm 55 19 a a DT work_fzrpauvhvnexhintldqhzusndm 55 20 greater great JJR work_fzrpauvhvnexhintldqhzusndm 55 21 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 55 22 of of IN work_fzrpauvhvnexhintldqhzusndm 55 23 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 55 24 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 55 25 systems system NNS work_fzrpauvhvnexhintldqhzusndm 55 26 . . . work_fzrpauvhvnexhintldqhzusndm 56 1 These these DT work_fzrpauvhvnexhintldqhzusndm 56 2 systems system NNS work_fzrpauvhvnexhintldqhzusndm 56 3 biology biology NN work_fzrpauvhvnexhintldqhzusndm 56 4 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 56 5 will will MD work_fzrpauvhvnexhintldqhzusndm 56 6 be be VB work_fzrpauvhvnexhintldqhzusndm 56 7 necessary necessary JJ work_fzrpauvhvnexhintldqhzusndm 56 8 in in IN work_fzrpauvhvnexhintldqhzusndm 56 9 order order NN work_fzrpauvhvnexhintldqhzusndm 56 10 to to TO work_fzrpauvhvnexhintldqhzusndm 56 11 make make VB work_fzrpauvhvnexhintldqhzusndm 56 12 sense sense NN work_fzrpauvhvnexhintldqhzusndm 56 13 of of IN work_fzrpauvhvnexhintldqhzusndm 56 14 the the DT work_fzrpauvhvnexhintldqhzusndm 56 15 complexity complexity NN work_fzrpauvhvnexhintldqhzusndm 56 16 of of IN work_fzrpauvhvnexhintldqhzusndm 56 17 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 56 18 that that WDT work_fzrpauvhvnexhintldqhzusndm 56 19 govern govern VBP work_fzrpauvhvnexhintldqhzusndm 56 20 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 56 21 development development NN work_fzrpauvhvnexhintldqhzusndm 56 22 and and CC work_fzrpauvhvnexhintldqhzusndm 56 23 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 56 24 . . . work_fzrpauvhvnexhintldqhzusndm 57 1 Systems system NNS work_fzrpauvhvnexhintldqhzusndm 57 2 biology biology NN work_fzrpauvhvnexhintldqhzusndm 57 3 begins begin VBZ work_fzrpauvhvnexhintldqhzusndm 57 4 with with IN work_fzrpauvhvnexhintldqhzusndm 57 5 the the DT work_fzrpauvhvnexhintldqhzusndm 57 6 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 57 7 that that IN work_fzrpauvhvnexhintldqhzusndm 57 8 cellular cellular JJ work_fzrpauvhvnexhintldqhzusndm 57 9 behavior behavior NN work_fzrpauvhvnexhintldqhzusndm 57 10 and and CC work_fzrpauvhvnexhintldqhzusndm 57 11 function function NN work_fzrpauvhvnexhintldqhzusndm 57 12 are be VBP work_fzrpauvhvnexhintldqhzusndm 57 13 emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 57 14 properties property NNS work_fzrpauvhvnexhintldqhzusndm 57 15 of of IN work_fzrpauvhvnexhintldqhzusndm 57 16 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 57 17 and and CC work_fzrpauvhvnexhintldqhzusndm 57 18 dynamic dynamic JJ work_fzrpauvhvnexhintldqhzusndm 57 19 interactions interaction NNS work_fzrpauvhvnexhintldqhzusndm 57 20 between between IN work_fzrpauvhvnexhintldqhzusndm 57 21 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 57 22 and and CC work_fzrpauvhvnexhintldqhzusndm 57 23 biomolecules biomolecule NNS work_fzrpauvhvnexhintldqhzusndm 57 24 . . . work_fzrpauvhvnexhintldqhzusndm 58 1 Emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 58 2 properties property NNS work_fzrpauvhvnexhintldqhzusndm 58 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 58 4 characteristics characteristic NNS work_fzrpauvhvnexhintldqhzusndm 58 5 of of IN work_fzrpauvhvnexhintldqhzusndm 58 6 the the DT work_fzrpauvhvnexhintldqhzusndm 58 7 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 58 8 system system NN work_fzrpauvhvnexhintldqhzusndm 58 9 that that WDT work_fzrpauvhvnexhintldqhzusndm 58 10 are be VBP work_fzrpauvhvnexhintldqhzusndm 58 11 not not RB work_fzrpauvhvnexhintldqhzusndm 58 12 present present JJ work_fzrpauvhvnexhintldqhzusndm 58 13 in in IN work_fzrpauvhvnexhintldqhzusndm 58 14 the the DT work_fzrpauvhvnexhintldqhzusndm 58 15 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 58 16 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 58 17 components component NNS work_fzrpauvhvnexhintldqhzusndm 58 18 and and CC work_fzrpauvhvnexhintldqhzusndm 58 19 , , , work_fzrpauvhvnexhintldqhzusndm 58 20 hence hence RB work_fzrpauvhvnexhintldqhzusndm 58 21 , , , work_fzrpauvhvnexhintldqhzusndm 58 22 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 58 23 systems system NNS work_fzrpauvhvnexhintldqhzusndm 58 24 are be VBP work_fzrpauvhvnexhintldqhzusndm 58 25 more more JJR work_fzrpauvhvnexhintldqhzusndm 58 26 than than IN work_fzrpauvhvnexhintldqhzusndm 58 27 the the DT work_fzrpauvhvnexhintldqhzusndm 58 28 sum sum NN work_fzrpauvhvnexhintldqhzusndm 58 29 of of IN work_fzrpauvhvnexhintldqhzusndm 58 30 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 58 31 parts part NNS work_fzrpauvhvnexhintldqhzusndm 58 32 . . . work_fzrpauvhvnexhintldqhzusndm 59 1 The the DT work_fzrpauvhvnexhintldqhzusndm 59 2 application application NN work_fzrpauvhvnexhintldqhzusndm 59 3 of of IN work_fzrpauvhvnexhintldqhzusndm 59 4 network network NN work_fzrpauvhvnexhintldqhzusndm 59 5 graph graph NN work_fzrpauvhvnexhintldqhzusndm 59 6 theory theory NN work_fzrpauvhvnexhintldqhzusndm 59 7 to to IN work_fzrpauvhvnexhintldqhzusndm 59 8 the the DT work_fzrpauvhvnexhintldqhzusndm 59 9 study study NN work_fzrpauvhvnexhintldqhzusndm 59 10 of of IN work_fzrpauvhvnexhintldqhzusndm 59 11 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 59 12 systems system NNS work_fzrpauvhvnexhintldqhzusndm 59 13 has have VBZ work_fzrpauvhvnexhintldqhzusndm 59 14 revealed reveal VBN work_fzrpauvhvnexhintldqhzusndm 59 15 that that IN work_fzrpauvhvnexhintldqhzusndm 59 16 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 59 17 systems system NNS work_fzrpauvhvnexhintldqhzusndm 59 18 are be VBP work_fzrpauvhvnexhintldqhzusndm 59 19 governed govern VBN work_fzrpauvhvnexhintldqhzusndm 59 20 by by IN work_fzrpauvhvnexhintldqhzusndm 59 21 a a DT work_fzrpauvhvnexhintldqhzusndm 59 22 set set NN work_fzrpauvhvnexhintldqhzusndm 59 23 of of IN work_fzrpauvhvnexhintldqhzusndm 59 24 universal universal JJ work_fzrpauvhvnexhintldqhzusndm 59 25 organizing organizing NN work_fzrpauvhvnexhintldqhzusndm 59 26 principles principle NNS work_fzrpauvhvnexhintldqhzusndm 59 27 , , , work_fzrpauvhvnexhintldqhzusndm 59 28 or or CC work_fzrpauvhvnexhintldqhzusndm 59 29 common common JJ work_fzrpauvhvnexhintldqhzusndm 59 30 design design NN work_fzrpauvhvnexhintldqhzusndm 59 31 elements element NNS work_fzrpauvhvnexhintldqhzusndm 59 32 that that WDT work_fzrpauvhvnexhintldqhzusndm 59 33 can can MD work_fzrpauvhvnexhintldqhzusndm 59 34 also also RB work_fzrpauvhvnexhintldqhzusndm 59 35 be be VB work_fzrpauvhvnexhintldqhzusndm 59 36 observed observe VBN work_fzrpauvhvnexhintldqhzusndm 59 37 in in IN work_fzrpauvhvnexhintldqhzusndm 59 38 man man NN work_fzrpauvhvnexhintldqhzusndm 59 39 - - HYPH work_fzrpauvhvnexhintldqhzusndm 59 40 made make VBN work_fzrpauvhvnexhintldqhzusndm 59 41 systems system NNS work_fzrpauvhvnexhintldqhzusndm 59 42 , , , work_fzrpauvhvnexhintldqhzusndm 59 43 such such JJ work_fzrpauvhvnexhintldqhzusndm 59 44 as as IN work_fzrpauvhvnexhintldqhzusndm 59 45 power power NN work_fzrpauvhvnexhintldqhzusndm 59 46 grids grid NNS work_fzrpauvhvnexhintldqhzusndm 59 47 and and CC work_fzrpauvhvnexhintldqhzusndm 59 48 the the DT work_fzrpauvhvnexhintldqhzusndm 59 49 world world NN work_fzrpauvhvnexhintldqhzusndm 59 50 wide wide JJ work_fzrpauvhvnexhintldqhzusndm 59 51 web web NN work_fzrpauvhvnexhintldqhzusndm 59 52 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 59 53 20 20 CD work_fzrpauvhvnexhintldqhzusndm 59 54 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 59 55 . . . work_fzrpauvhvnexhintldqhzusndm 60 1 Complex complex JJ work_fzrpauvhvnexhintldqhzusndm 60 2 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 60 3 systems system NNS work_fzrpauvhvnexhintldqhzusndm 60 4 have have VBP work_fzrpauvhvnexhintldqhzusndm 60 5 a a DT work_fzrpauvhvnexhintldqhzusndm 60 6 scale scale NN work_fzrpauvhvnexhintldqhzusndm 60 7 - - HYPH work_fzrpauvhvnexhintldqhzusndm 60 8 free free JJ work_fzrpauvhvnexhintldqhzusndm 60 9 architecture architecture NN work_fzrpauvhvnexhintldqhzusndm 60 10 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 60 11 figure figure NNP work_fzrpauvhvnexhintldqhzusndm 60 12 1 1 CD work_fzrpauvhvnexhintldqhzusndm 60 13 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 60 14 , , , work_fzrpauvhvnexhintldqhzusndm 60 15 where where WRB work_fzrpauvhvnexhintldqhzusndm 60 16 most most JJS work_fzrpauvhvnexhintldqhzusndm 60 17 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 60 18 are be VBP work_fzrpauvhvnexhintldqhzusndm 60 19 interlinked interlink VBN work_fzrpauvhvnexhintldqhzusndm 60 20 with with IN work_fzrpauvhvnexhintldqhzusndm 60 21 a a DT work_fzrpauvhvnexhintldqhzusndm 60 22 few few JJ work_fzrpauvhvnexhintldqhzusndm 60 23 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 60 24 , , , work_fzrpauvhvnexhintldqhzusndm 60 25 and and CC work_fzrpauvhvnexhintldqhzusndm 60 26 a a DT work_fzrpauvhvnexhintldqhzusndm 60 27 few few JJ work_fzrpauvhvnexhintldqhzusndm 60 28 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 60 29 interact interact VBP work_fzrpauvhvnexhintldqhzusndm 60 30 with with IN work_fzrpauvhvnexhintldqhzusndm 60 31 many many JJ work_fzrpauvhvnexhintldqhzusndm 60 32 , , , work_fzrpauvhvnexhintldqhzusndm 60 33 giving give VBG work_fzrpauvhvnexhintldqhzusndm 60 34 rise rise NN work_fzrpauvhvnexhintldqhzusndm 60 35 to to IN work_fzrpauvhvnexhintldqhzusndm 60 36 hubs hubs VB work_fzrpauvhvnexhintldqhzusndm 60 37 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 60 38 21–23 21–23 NN work_fzrpauvhvnexhintldqhzusndm 60 39 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 60 40 . . . work_fzrpauvhvnexhintldqhzusndm 61 1 Figure figure NN work_fzrpauvhvnexhintldqhzusndm 61 2 1 1 CD work_fzrpauvhvnexhintldqhzusndm 61 3 . . . work_fzrpauvhvnexhintldqhzusndm 62 1 Emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 62 2 properties property NNS work_fzrpauvhvnexhintldqhzusndm 62 3 of of IN work_fzrpauvhvnexhintldqhzusndm 62 4 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 62 5 networks network NNS work_fzrpauvhvnexhintldqhzusndm 62 6 . . . work_fzrpauvhvnexhintldqhzusndm 63 1 Scale scale NN work_fzrpauvhvnexhintldqhzusndm 63 2 - - HYPH work_fzrpauvhvnexhintldqhzusndm 63 3 free free JJ work_fzrpauvhvnexhintldqhzusndm 63 4 networks network NNS work_fzrpauvhvnexhintldqhzusndm 63 5 follow follow VBP work_fzrpauvhvnexhintldqhzusndm 63 6 a a DT work_fzrpauvhvnexhintldqhzusndm 63 7 power power NN work_fzrpauvhvnexhintldqhzusndm 63 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 63 9 law law NN work_fzrpauvhvnexhintldqhzusndm 63 10 degree degree NN work_fzrpauvhvnexhintldqhzusndm 63 11 distribution distribution NN work_fzrpauvhvnexhintldqhzusndm 63 12 , , , work_fzrpauvhvnexhintldqhzusndm 63 13 meaning mean VBG work_fzrpauvhvnexhintldqhzusndm 63 14 that that IN work_fzrpauvhvnexhintldqhzusndm 63 15 most most JJS work_fzrpauvhvnexhintldqhzusndm 63 16 nodes node NNS work_fzrpauvhvnexhintldqhzusndm 63 17 have have VBP work_fzrpauvhvnexhintldqhzusndm 63 18 few few JJ work_fzrpauvhvnexhintldqhzusndm 63 19 links link NNS work_fzrpauvhvnexhintldqhzusndm 63 20 , , , work_fzrpauvhvnexhintldqhzusndm 63 21 and and CC work_fzrpauvhvnexhintldqhzusndm 63 22 a a DT work_fzrpauvhvnexhintldqhzusndm 63 23 few few JJ work_fzrpauvhvnexhintldqhzusndm 63 24 nodes node NNS work_fzrpauvhvnexhintldqhzusndm 63 25 have have VBP work_fzrpauvhvnexhintldqhzusndm 63 26 many many JJ work_fzrpauvhvnexhintldqhzusndm 63 27 links link NNS work_fzrpauvhvnexhintldqhzusndm 63 28 . . . work_fzrpauvhvnexhintldqhzusndm 64 1 Modules module NNS work_fzrpauvhvnexhintldqhzusndm 64 2 are be VBP work_fzrpauvhvnexhintldqhzusndm 64 3 subnets subnet NNS work_fzrpauvhvnexhintldqhzusndm 64 4 comprised comprise VBN work_fzrpauvhvnexhintldqhzusndm 64 5 of of IN work_fzrpauvhvnexhintldqhzusndm 64 6 proteins protein NNS work_fzrpauvhvnexhintldqhzusndm 64 7 that that WDT work_fzrpauvhvnexhintldqhzusndm 64 8 function function VBP work_fzrpauvhvnexhintldqhzusndm 64 9 in in IN work_fzrpauvhvnexhintldqhzusndm 64 10 the the DT work_fzrpauvhvnexhintldqhzusndm 64 11 same same JJ work_fzrpauvhvnexhintldqhzusndm 64 12 pathway pathway NN work_fzrpauvhvnexhintldqhzusndm 64 13 . . . work_fzrpauvhvnexhintldqhzusndm 65 1 The the DT work_fzrpauvhvnexhintldqhzusndm 65 2 innate innate JJ work_fzrpauvhvnexhintldqhzusndm 65 3 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 65 4 system system NN work_fzrpauvhvnexhintldqhzusndm 65 5 employs employ VBZ work_fzrpauvhvnexhintldqhzusndm 65 6 a a DT work_fzrpauvhvnexhintldqhzusndm 65 7 bow bow VB work_fzrpauvhvnexhintldqhzusndm 65 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 65 9 tie tie NN work_fzrpauvhvnexhintldqhzusndm 65 10 architecture architecture NN work_fzrpauvhvnexhintldqhzusndm 65 11 to to TO work_fzrpauvhvnexhintldqhzusndm 65 12 integrate integrate VB work_fzrpauvhvnexhintldqhzusndm 65 13 diverse diverse JJ work_fzrpauvhvnexhintldqhzusndm 65 14 signals signal NNS work_fzrpauvhvnexhintldqhzusndm 65 15 from from IN work_fzrpauvhvnexhintldqhzusndm 65 16 a a DT work_fzrpauvhvnexhintldqhzusndm 65 17 fluctuating fluctuate VBG work_fzrpauvhvnexhintldqhzusndm 65 18 environment environment NN work_fzrpauvhvnexhintldqhzusndm 65 19 . . . work_fzrpauvhvnexhintldqhzusndm 66 1 As as IN work_fzrpauvhvnexhintldqhzusndm 66 2 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 66 3 networks network NNS work_fzrpauvhvnexhintldqhzusndm 66 4 evolve evolve VBP work_fzrpauvhvnexhintldqhzusndm 66 5 and and CC work_fzrpauvhvnexhintldqhzusndm 66 6 add add VB work_fzrpauvhvnexhintldqhzusndm 66 7 new new JJ work_fzrpauvhvnexhintldqhzusndm 66 8 components component NNS work_fzrpauvhvnexhintldqhzusndm 66 9 , , , work_fzrpauvhvnexhintldqhzusndm 66 10 the the DT work_fzrpauvhvnexhintldqhzusndm 66 11 probability probability NN work_fzrpauvhvnexhintldqhzusndm 66 12 of of IN work_fzrpauvhvnexhintldqhzusndm 66 13 adding add VBG work_fzrpauvhvnexhintldqhzusndm 66 14 new new JJ work_fzrpauvhvnexhintldqhzusndm 66 15 links link NNS work_fzrpauvhvnexhintldqhzusndm 66 16 to to IN work_fzrpauvhvnexhintldqhzusndm 66 17 an an DT work_fzrpauvhvnexhintldqhzusndm 66 18 existing exist VBG work_fzrpauvhvnexhintldqhzusndm 66 19 component component NN work_fzrpauvhvnexhintldqhzusndm 66 20 is be VBZ work_fzrpauvhvnexhintldqhzusndm 66 21 proportional proportional JJ work_fzrpauvhvnexhintldqhzusndm 66 22 to to IN work_fzrpauvhvnexhintldqhzusndm 66 23 the the DT work_fzrpauvhvnexhintldqhzusndm 66 24 number number NN work_fzrpauvhvnexhintldqhzusndm 66 25 of of IN work_fzrpauvhvnexhintldqhzusndm 66 26 links link NNS work_fzrpauvhvnexhintldqhzusndm 66 27 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 66 28 already already RB work_fzrpauvhvnexhintldqhzusndm 66 29 has have VBZ work_fzrpauvhvnexhintldqhzusndm 66 30 , , , work_fzrpauvhvnexhintldqhzusndm 66 31 and and CC work_fzrpauvhvnexhintldqhzusndm 66 32 this this DT work_fzrpauvhvnexhintldqhzusndm 66 33 generates generate VBZ work_fzrpauvhvnexhintldqhzusndm 66 34 hubs hubs VBP work_fzrpauvhvnexhintldqhzusndm 66 35 through through IN work_fzrpauvhvnexhintldqhzusndm 66 36 a a DT work_fzrpauvhvnexhintldqhzusndm 66 37 mechanism mechanism NN work_fzrpauvhvnexhintldqhzusndm 66 38 known know VBN work_fzrpauvhvnexhintldqhzusndm 66 39 as as IN work_fzrpauvhvnexhintldqhzusndm 66 40 Preferential Preferential NNP work_fzrpauvhvnexhintldqhzusndm 66 41 Attachment Attachment NNP work_fzrpauvhvnexhintldqhzusndm 66 42 or or CC work_fzrpauvhvnexhintldqhzusndm 66 43 Rich rich JJ work_fzrpauvhvnexhintldqhzusndm 66 44 - - HYPH work_fzrpauvhvnexhintldqhzusndm 66 45 get get VB work_fzrpauvhvnexhintldqhzusndm 66 46 - - HYPH work_fzrpauvhvnexhintldqhzusndm 66 47 Richer richer NN work_fzrpauvhvnexhintldqhzusndm 66 48 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 66 49 24 24 CD work_fzrpauvhvnexhintldqhzusndm 66 50 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 66 51 . . . work_fzrpauvhvnexhintldqhzusndm 67 1 Biological biological JJ work_fzrpauvhvnexhintldqhzusndm 67 2 networks network NNS work_fzrpauvhvnexhintldqhzusndm 67 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 67 4 also also RB work_fzrpauvhvnexhintldqhzusndm 67 5 modular modular JJ work_fzrpauvhvnexhintldqhzusndm 67 6 , , , work_fzrpauvhvnexhintldqhzusndm 67 7 meaning mean VBG work_fzrpauvhvnexhintldqhzusndm 67 8 that that IN work_fzrpauvhvnexhintldqhzusndm 67 9 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 67 10 which which WDT work_fzrpauvhvnexhintldqhzusndm 67 11 function function VBP work_fzrpauvhvnexhintldqhzusndm 67 12 in in IN work_fzrpauvhvnexhintldqhzusndm 67 13 the the DT work_fzrpauvhvnexhintldqhzusndm 67 14 same same JJ work_fzrpauvhvnexhintldqhzusndm 67 15 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 67 16 process process NN work_fzrpauvhvnexhintldqhzusndm 67 17 form form NN work_fzrpauvhvnexhintldqhzusndm 67 18 communities community NNS work_fzrpauvhvnexhintldqhzusndm 67 19 in in IN work_fzrpauvhvnexhintldqhzusndm 67 20 the the DT work_fzrpauvhvnexhintldqhzusndm 67 21 network network NN work_fzrpauvhvnexhintldqhzusndm 67 22 structure structure NN work_fzrpauvhvnexhintldqhzusndm 67 23 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 67 24 figure figure NN work_fzrpauvhvnexhintldqhzusndm 67 25 1 1 CD work_fzrpauvhvnexhintldqhzusndm 67 26 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 67 27 . . . work_fzrpauvhvnexhintldqhzusndm 68 1 Smaller small JJR work_fzrpauvhvnexhintldqhzusndm 68 2 modules module NNS work_fzrpauvhvnexhintldqhzusndm 68 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 68 4 embedded embed VBN work_fzrpauvhvnexhintldqhzusndm 68 5 within within IN work_fzrpauvhvnexhintldqhzusndm 68 6 larger large JJR work_fzrpauvhvnexhintldqhzusndm 68 7 modules module NNS work_fzrpauvhvnexhintldqhzusndm 68 8 , , , work_fzrpauvhvnexhintldqhzusndm 68 9 giving give VBG work_fzrpauvhvnexhintldqhzusndm 68 10 rise rise NN work_fzrpauvhvnexhintldqhzusndm 68 11 to to IN work_fzrpauvhvnexhintldqhzusndm 68 12 hierarchical hierarchical JJ work_fzrpauvhvnexhintldqhzusndm 68 13 organization organization NN work_fzrpauvhvnexhintldqhzusndm 68 14 . . . work_fzrpauvhvnexhintldqhzusndm 69 1 Biological biological JJ work_fzrpauvhvnexhintldqhzusndm 69 2 networks network NNS work_fzrpauvhvnexhintldqhzusndm 69 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 69 4 small small JJ work_fzrpauvhvnexhintldqhzusndm 69 5 world world NN work_fzrpauvhvnexhintldqhzusndm 69 6 , , , work_fzrpauvhvnexhintldqhzusndm 69 7 meaning mean VBG work_fzrpauvhvnexhintldqhzusndm 69 8 that that IN work_fzrpauvhvnexhintldqhzusndm 69 9 you -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 69 10 can can MD work_fzrpauvhvnexhintldqhzusndm 69 11 “ " `` work_fzrpauvhvnexhintldqhzusndm 69 12 hop hop VB work_fzrpauvhvnexhintldqhzusndm 69 13 ” " '' work_fzrpauvhvnexhintldqhzusndm 69 14 through through IN work_fzrpauvhvnexhintldqhzusndm 69 15 the the DT work_fzrpauvhvnexhintldqhzusndm 69 16 network network NN work_fzrpauvhvnexhintldqhzusndm 69 17 from from IN work_fzrpauvhvnexhintldqhzusndm 69 18 one one CD work_fzrpauvhvnexhintldqhzusndm 69 19 gene gene NN work_fzrpauvhvnexhintldqhzusndm 69 20 to to IN work_fzrpauvhvnexhintldqhzusndm 69 21 any any DT work_fzrpauvhvnexhintldqhzusndm 69 22 other other JJ work_fzrpauvhvnexhintldqhzusndm 69 23 gene gene NN work_fzrpauvhvnexhintldqhzusndm 69 24 in in IN work_fzrpauvhvnexhintldqhzusndm 69 25 a a DT work_fzrpauvhvnexhintldqhzusndm 69 26 few few JJ work_fzrpauvhvnexhintldqhzusndm 69 27 steps step NNS work_fzrpauvhvnexhintldqhzusndm 69 28 . . . work_fzrpauvhvnexhintldqhzusndm 70 1 Finally finally RB work_fzrpauvhvnexhintldqhzusndm 70 2 , , , work_fzrpauvhvnexhintldqhzusndm 70 3 a a DT work_fzrpauvhvnexhintldqhzusndm 70 4 key key JJ work_fzrpauvhvnexhintldqhzusndm 70 5 Figure figure NN work_fzrpauvhvnexhintldqhzusndm 70 6 1 1 CD work_fzrpauvhvnexhintldqhzusndm 70 7 . . . work_fzrpauvhvnexhintldqhzusndm 71 1 Emergent emergent JJ work_fzrpauvhvnexhintldqhzusndm 71 2 properties property NNS work_fzrpauvhvnexhintldqhzusndm 71 3 of of IN work_fzrpauvhvnexhintldqhzusndm 71 4 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 71 5 networks network NNS work_fzrpauvhvnexhintldqhzusndm 71 6 . . . work_fzrpauvhvnexhintldqhzusndm 72 1 Scale scale NN work_fzrpauvhvnexhintldqhzusndm 72 2 - - HYPH work_fzrpauvhvnexhintldqhzusndm 72 3 free free JJ work_fzrpauvhvnexhintldqhzusndm 72 4 networks network NNS work_fzrpauvhvnexhintldqhzusndm 72 5 follow follow VBP work_fzrpauvhvnexhintldqhzusndm 72 6 a a DT work_fzrpauvhvnexhintldqhzusndm 72 7 power power NN work_fzrpauvhvnexhintldqhzusndm 72 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 72 9 law law NN work_fzrpauvhvnexhintldqhzusndm 72 10 degree degree NN work_fzrpauvhvnexhintldqhzusndm 72 11 distribution distribution NN work_fzrpauvhvnexhintldqhzusndm 72 12 , , , work_fzrpauvhvnexhintldqhzusndm 72 13 meaning mean VBG work_fzrpauvhvnexhintldqhzusndm 72 14 that that IN work_fzrpauvhvnexhintldqhzusndm 72 15 most most JJS work_fzrpauvhvnexhintldqhzusndm 72 16 nodes node NNS work_fzrpauvhvnexhintldqhzusndm 72 17 have have VBP work_fzrpauvhvnexhintldqhzusndm 72 18 few few JJ work_fzrpauvhvnexhintldqhzusndm 72 19 links link NNS work_fzrpauvhvnexhintldqhzusndm 72 20 , , , work_fzrpauvhvnexhintldqhzusndm 72 21 and and CC work_fzrpauvhvnexhintldqhzusndm 72 22 a a DT work_fzrpauvhvnexhintldqhzusndm 72 23 few few JJ work_fzrpauvhvnexhintldqhzusndm 72 24 nodes node NNS work_fzrpauvhvnexhintldqhzusndm 72 25 have have VBP work_fzrpauvhvnexhintldqhzusndm 72 26 many many JJ work_fzrpauvhvnexhintldqhzusndm 72 27 links link NNS work_fzrpauvhvnexhintldqhzusndm 72 28 . . . work_fzrpauvhvnexhintldqhzusndm 73 1 Modules module NNS work_fzrpauvhvnexhintldqhzusndm 73 2 are be VBP work_fzrpauvhvnexhintldqhzusndm 73 3 subnets subnet NNS work_fzrpauvhvnexhintldqhzusndm 73 4 comprised comprise VBN work_fzrpauvhvnexhintldqhzusndm 73 5 of of IN work_fzrpauvhvnexhintldqhzusndm 73 6 proteins protein NNS work_fzrpauvhvnexhintldqhzusndm 73 7 that that WDT work_fzrpauvhvnexhintldqhzusndm 73 8 function function VBP work_fzrpauvhvnexhintldqhzusndm 73 9 in in IN work_fzrpauvhvnexhintldqhzusndm 73 10 the the DT work_fzrpauvhvnexhintldqhzusndm 73 11 same same JJ work_fzrpauvhvnexhintldqhzusndm 73 12 pathway pathway NN work_fzrpauvhvnexhintldqhzusndm 73 13 . . . work_fzrpauvhvnexhintldqhzusndm 74 1 The the DT work_fzrpauvhvnexhintldqhzusndm 74 2 innate innate JJ work_fzrpauvhvnexhintldqhzusndm 74 3 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 74 4 system system NN work_fzrpauvhvnexhintldqhzusndm 74 5 employs employ VBZ work_fzrpauvhvnexhintldqhzusndm 74 6 a a DT work_fzrpauvhvnexhintldqhzusndm 74 7 bow bow VB work_fzrpauvhvnexhintldqhzusndm 74 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 74 9 tie tie NN work_fzrpauvhvnexhintldqhzusndm 74 10 architecture architecture NN work_fzrpauvhvnexhintldqhzusndm 74 11 to to TO work_fzrpauvhvnexhintldqhzusndm 74 12 integrate integrate VB work_fzrpauvhvnexhintldqhzusndm 74 13 diverse diverse JJ work_fzrpauvhvnexhintldqhzusndm 74 14 signals signal NNS work_fzrpauvhvnexhintldqhzusndm 74 15 from from IN work_fzrpauvhvnexhintldqhzusndm 74 16 a a DT work_fzrpauvhvnexhintldqhzusndm 74 17 fluctuating fluctuate VBG work_fzrpauvhvnexhintldqhzusndm 74 18 environment environment NN work_fzrpauvhvnexhintldqhzusndm 74 19 . . . work_fzrpauvhvnexhintldqhzusndm 75 1 As as IN work_fzrpauvhvnexhintldqhzusndm 75 2 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 75 3 networks network NNS work_fzrpauvhvnexhintldqhzusndm 75 4 evolve evolve VBP work_fzrpauvhvnexhintldqhzusndm 75 5 and and CC work_fzrpauvhvnexhintldqhzusndm 75 6 add add VB work_fzrpauvhvnexhintldqhzusndm 75 7 new new JJ work_fzrpauvhvnexhintldqhzusndm 75 8 components component NNS work_fzrpauvhvnexhintldqhzusndm 75 9 , , , work_fzrpauvhvnexhintldqhzusndm 75 10 the the DT work_fzrpauvhvnexhintldqhzusndm 75 11 probability probability NN work_fzrpauvhvnexhintldqhzusndm 75 12 of of IN work_fzrpauvhvnexhintldqhzusndm 75 13 adding add VBG work_fzrpauvhvnexhintldqhzusndm 75 14 new new JJ work_fzrpauvhvnexhintldqhzusndm 75 15 links link NNS work_fzrpauvhvnexhintldqhzusndm 75 16 to to IN work_fzrpauvhvnexhintldqhzusndm 75 17 an an DT work_fzrpauvhvnexhintldqhzusndm 75 18 existing exist VBG work_fzrpauvhvnexhintldqhzusndm 75 19 component component NN work_fzrpauvhvnexhintldqhzusndm 75 20 is be VBZ work_fzrpauvhvnexhintldqhzusndm 75 21 proportional proportional JJ work_fzrpauvhvnexhintldqhzusndm 75 22 to to IN work_fzrpauvhvnexhintldqhzusndm 75 23 the the DT work_fzrpauvhvnexhintldqhzusndm 75 24 number number NN work_fzrpauvhvnexhintldqhzusndm 75 25 of of IN work_fzrpauvhvnexhintldqhzusndm 75 26 links link NNS work_fzrpauvhvnexhintldqhzusndm 75 27 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 75 28 already already RB work_fzrpauvhvnexhintldqhzusndm 75 29 has have VBZ work_fzrpauvhvnexhintldqhzusndm 75 30 , , , work_fzrpauvhvnexhintldqhzusndm 75 31 and and CC work_fzrpauvhvnexhintldqhzusndm 75 32 this this DT work_fzrpauvhvnexhintldqhzusndm 75 33 generates generate VBZ work_fzrpauvhvnexhintldqhzusndm 75 34 hubs hubs VBP work_fzrpauvhvnexhintldqhzusndm 75 35 through through IN work_fzrpauvhvnexhintldqhzusndm 75 36 a a DT work_fzrpauvhvnexhintldqhzusndm 75 37 mechanism mechanism NN work_fzrpauvhvnexhintldqhzusndm 75 38 known know VBN work_fzrpauvhvnexhintldqhzusndm 75 39 as as IN work_fzrpauvhvnexhintldqhzusndm 75 40 Preferential Preferential NNP work_fzrpauvhvnexhintldqhzusndm 75 41 Attachment Attachment NNP work_fzrpauvhvnexhintldqhzusndm 75 42 or or CC work_fzrpauvhvnexhintldqhzusndm 75 43 Rich rich JJ work_fzrpauvhvnexhintldqhzusndm 75 44 - - HYPH work_fzrpauvhvnexhintldqhzusndm 75 45 get get VB work_fzrpauvhvnexhintldqhzusndm 75 46 - - HYPH work_fzrpauvhvnexhintldqhzusndm 75 47 Richer richer NN work_fzrpauvhvnexhintldqhzusndm 75 48 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 75 49 24 24 CD work_fzrpauvhvnexhintldqhzusndm 75 50 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 75 51 . . . work_fzrpauvhvnexhintldqhzusndm 76 1 Biological biological JJ work_fzrpauvhvnexhintldqhzusndm 76 2 networks network NNS work_fzrpauvhvnexhintldqhzusndm 76 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 76 4 also also RB work_fzrpauvhvnexhintldqhzusndm 76 5 modular modular JJ work_fzrpauvhvnexhintldqhzusndm 76 6 , , , work_fzrpauvhvnexhintldqhzusndm 76 7 meaning mean VBG work_fzrpauvhvnexhintldqhzusndm 76 8 that that IN work_fzrpauvhvnexhintldqhzusndm 76 9 genes gene NNS work_fzrpauvhvnexhintldqhzusndm 76 10 which which WDT work_fzrpauvhvnexhintldqhzusndm 76 11 function function VBP work_fzrpauvhvnexhintldqhzusndm 76 12 in in IN work_fzrpauvhvnexhintldqhzusndm 76 13 the the DT work_fzrpauvhvnexhintldqhzusndm 76 14 same same JJ work_fzrpauvhvnexhintldqhzusndm 76 15 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 76 16 process process NN work_fzrpauvhvnexhintldqhzusndm 76 17 form form NN work_fzrpauvhvnexhintldqhzusndm 76 18 communities community NNS work_fzrpauvhvnexhintldqhzusndm 76 19 in in IN work_fzrpauvhvnexhintldqhzusndm 76 20 the the DT work_fzrpauvhvnexhintldqhzusndm 76 21 network network NN work_fzrpauvhvnexhintldqhzusndm 76 22 structure structure NN work_fzrpauvhvnexhintldqhzusndm 76 23 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 76 24 Figure figure NN work_fzrpauvhvnexhintldqhzusndm 76 25 1 1 CD work_fzrpauvhvnexhintldqhzusndm 76 26 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 76 27 . . . work_fzrpauvhvnexhintldqhzusndm 77 1 Smaller small JJR work_fzrpauvhvnexhintldqhzusndm 77 2 modules module NNS work_fzrpauvhvnexhintldqhzusndm 77 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 77 4 embedded embed VBN work_fzrpauvhvnexhintldqhzusndm 77 5 within within IN work_fzrpauvhvnexhintldqhzusndm 77 6 larger large JJR work_fzrpauvhvnexhintldqhzusndm 77 7 modules module NNS work_fzrpauvhvnexhintldqhzusndm 77 8 , , , work_fzrpauvhvnexhintldqhzusndm 77 9 giving give VBG work_fzrpauvhvnexhintldqhzusndm 77 10 rise rise NN work_fzrpauvhvnexhintldqhzusndm 77 11 to to IN work_fzrpauvhvnexhintldqhzusndm 77 12 hierarchical hierarchical JJ work_fzrpauvhvnexhintldqhzusndm 77 13 organization organization NN work_fzrpauvhvnexhintldqhzusndm 77 14 . . . work_fzrpauvhvnexhintldqhzusndm 78 1 Biological biological JJ work_fzrpauvhvnexhintldqhzusndm 78 2 networks network NNS work_fzrpauvhvnexhintldqhzusndm 78 3 are be VBP work_fzrpauvhvnexhintldqhzusndm 78 4 small small JJ work_fzrpauvhvnexhintldqhzusndm 78 5 world world NN work_fzrpauvhvnexhintldqhzusndm 78 6 , , , work_fzrpauvhvnexhintldqhzusndm 78 7 meaning mean VBG work_fzrpauvhvnexhintldqhzusndm 78 8 that that IN work_fzrpauvhvnexhintldqhzusndm 78 9 you -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 78 10 can can MD work_fzrpauvhvnexhintldqhzusndm 78 11 “ " `` work_fzrpauvhvnexhintldqhzusndm 78 12 hop hop VB work_fzrpauvhvnexhintldqhzusndm 78 13 ” " '' work_fzrpauvhvnexhintldqhzusndm 78 14 through through IN work_fzrpauvhvnexhintldqhzusndm 78 15 the the DT work_fzrpauvhvnexhintldqhzusndm 78 16 network network NN work_fzrpauvhvnexhintldqhzusndm 78 17 from from IN work_fzrpauvhvnexhintldqhzusndm 78 18 one one CD work_fzrpauvhvnexhintldqhzusndm 78 19 gene gene NN work_fzrpauvhvnexhintldqhzusndm 78 20 to to IN work_fzrpauvhvnexhintldqhzusndm 78 21 any any DT work_fzrpauvhvnexhintldqhzusndm 78 22 other other JJ work_fzrpauvhvnexhintldqhzusndm 78 23 gene gene NN work_fzrpauvhvnexhintldqhzusndm 78 24 in in IN work_fzrpauvhvnexhintldqhzusndm 78 25 a a DT work_fzrpauvhvnexhintldqhzusndm 78 26 few few JJ work_fzrpauvhvnexhintldqhzusndm 78 27 steps step NNS work_fzrpauvhvnexhintldqhzusndm 78 28 . . . work_fzrpauvhvnexhintldqhzusndm 79 1 Finally finally RB work_fzrpauvhvnexhintldqhzusndm 79 2 , , , work_fzrpauvhvnexhintldqhzusndm 79 3 a a DT work_fzrpauvhvnexhintldqhzusndm 79 4 key key JJ work_fzrpauvhvnexhintldqhzusndm 79 5 challenge challenge NN work_fzrpauvhvnexhintldqhzusndm 79 6 for for IN work_fzrpauvhvnexhintldqhzusndm 79 7 the the DT work_fzrpauvhvnexhintldqhzusndm 79 8 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 79 9 system system NN work_fzrpauvhvnexhintldqhzusndm 79 10 is be VBZ work_fzrpauvhvnexhintldqhzusndm 79 11 to to TO work_fzrpauvhvnexhintldqhzusndm 79 12 interpret interpret VB work_fzrpauvhvnexhintldqhzusndm 79 13 and and CC work_fzrpauvhvnexhintldqhzusndm 79 14 respond respond VB work_fzrpauvhvnexhintldqhzusndm 79 15 to to IN work_fzrpauvhvnexhintldqhzusndm 79 16 diverse diverse JJ work_fzrpauvhvnexhintldqhzusndm 79 17 and and CC work_fzrpauvhvnexhintldqhzusndm 79 18 fluctuating fluctuate VBG work_fzrpauvhvnexhintldqhzusndm 79 19 signals signal NNS work_fzrpauvhvnexhintldqhzusndm 79 20 in in IN work_fzrpauvhvnexhintldqhzusndm 79 21 order order NN work_fzrpauvhvnexhintldqhzusndm 79 22 to to TO work_fzrpauvhvnexhintldqhzusndm 79 23 maintain maintain VB work_fzrpauvhvnexhintldqhzusndm 79 24 homeostasis homeostasis NN work_fzrpauvhvnexhintldqhzusndm 79 25 . . . work_fzrpauvhvnexhintldqhzusndm 80 1 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 80 2 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 80 3 , , , work_fzrpauvhvnexhintldqhzusndm 80 4 10 10 CD work_fzrpauvhvnexhintldqhzusndm 80 5 , , , work_fzrpauvhvnexhintldqhzusndm 80 6 23 23 CD work_fzrpauvhvnexhintldqhzusndm 80 7 4 4 CD work_fzrpauvhvnexhintldqhzusndm 80 8 of of IN work_fzrpauvhvnexhintldqhzusndm 80 9 9 9 CD work_fzrpauvhvnexhintldqhzusndm 80 10 This this DT work_fzrpauvhvnexhintldqhzusndm 80 11 is be VBZ work_fzrpauvhvnexhintldqhzusndm 80 12 achieved achieve VBN work_fzrpauvhvnexhintldqhzusndm 80 13 through through IN work_fzrpauvhvnexhintldqhzusndm 80 14 a a DT work_fzrpauvhvnexhintldqhzusndm 80 15 bow bow VB work_fzrpauvhvnexhintldqhzusndm 80 16 - - HYPH work_fzrpauvhvnexhintldqhzusndm 80 17 tie tie NN work_fzrpauvhvnexhintldqhzusndm 80 18 signal signal NN work_fzrpauvhvnexhintldqhzusndm 80 19 processing processing NN work_fzrpauvhvnexhintldqhzusndm 80 20 control control NN work_fzrpauvhvnexhintldqhzusndm 80 21 system system NN work_fzrpauvhvnexhintldqhzusndm 80 22 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 80 23 25 25 CD work_fzrpauvhvnexhintldqhzusndm 80 24 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 80 25 . . . work_fzrpauvhvnexhintldqhzusndm 81 1 The the DT work_fzrpauvhvnexhintldqhzusndm 81 2 bow bow NN work_fzrpauvhvnexhintldqhzusndm 81 3 - - HYPH work_fzrpauvhvnexhintldqhzusndm 81 4 tie tie NN work_fzrpauvhvnexhintldqhzusndm 81 5 structure structure NN work_fzrpauvhvnexhintldqhzusndm 81 6 receives receive VBZ work_fzrpauvhvnexhintldqhzusndm 81 7 diverse diverse JJ work_fzrpauvhvnexhintldqhzusndm 81 8 input input NN work_fzrpauvhvnexhintldqhzusndm 81 9 signals signal NNS work_fzrpauvhvnexhintldqhzusndm 81 10 and and CC work_fzrpauvhvnexhintldqhzusndm 81 11 processes process VBZ work_fzrpauvhvnexhintldqhzusndm 81 12 them -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 81 13 through through IN work_fzrpauvhvnexhintldqhzusndm 81 14 a a DT work_fzrpauvhvnexhintldqhzusndm 81 15 core core NN work_fzrpauvhvnexhintldqhzusndm 81 16 , , , work_fzrpauvhvnexhintldqhzusndm 81 17 and and CC work_fzrpauvhvnexhintldqhzusndm 81 18 this this DT work_fzrpauvhvnexhintldqhzusndm 81 19 generates generate VBZ work_fzrpauvhvnexhintldqhzusndm 81 20 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 81 21 output output NN work_fzrpauvhvnexhintldqhzusndm 81 22 signals signal NNS work_fzrpauvhvnexhintldqhzusndm 81 23 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 81 24 Figure figure NN work_fzrpauvhvnexhintldqhzusndm 81 25 1 1 CD work_fzrpauvhvnexhintldqhzusndm 81 26 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 81 27 . . . work_fzrpauvhvnexhintldqhzusndm 82 1 The the DT work_fzrpauvhvnexhintldqhzusndm 82 2 bow bow NN work_fzrpauvhvnexhintldqhzusndm 82 3 - - HYPH work_fzrpauvhvnexhintldqhzusndm 82 4 tie tie NN work_fzrpauvhvnexhintldqhzusndm 82 5 architecture architecture NN work_fzrpauvhvnexhintldqhzusndm 82 6 is be VBZ work_fzrpauvhvnexhintldqhzusndm 82 7 an an DT work_fzrpauvhvnexhintldqhzusndm 82 8 important important JJ work_fzrpauvhvnexhintldqhzusndm 82 9 conceptual conceptual JJ work_fzrpauvhvnexhintldqhzusndm 82 10 advance advance NN work_fzrpauvhvnexhintldqhzusndm 82 11 in in IN work_fzrpauvhvnexhintldqhzusndm 82 12 our -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 82 13 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 82 14 of of IN work_fzrpauvhvnexhintldqhzusndm 82 15 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 82 16 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 82 17 because because IN work_fzrpauvhvnexhintldqhzusndm 82 18 genetic genetic JJ work_fzrpauvhvnexhintldqhzusndm 82 19 or or CC work_fzrpauvhvnexhintldqhzusndm 82 20 environmental environmental JJ work_fzrpauvhvnexhintldqhzusndm 82 21 perturbation perturbation NN work_fzrpauvhvnexhintldqhzusndm 82 22 of of IN work_fzrpauvhvnexhintldqhzusndm 82 23 the the DT work_fzrpauvhvnexhintldqhzusndm 82 24 input input NN work_fzrpauvhvnexhintldqhzusndm 82 25 and and CC work_fzrpauvhvnexhintldqhzusndm 82 26 output output NN work_fzrpauvhvnexhintldqhzusndm 82 27 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 82 28 will will MD work_fzrpauvhvnexhintldqhzusndm 82 29 generate generate VB work_fzrpauvhvnexhintldqhzusndm 82 30 lots lot NNS work_fzrpauvhvnexhintldqhzusndm 82 31 of of IN work_fzrpauvhvnexhintldqhzusndm 82 32 noise noise NN work_fzrpauvhvnexhintldqhzusndm 82 33 and and CC work_fzrpauvhvnexhintldqhzusndm 82 34 complexity complexity NN work_fzrpauvhvnexhintldqhzusndm 82 35 but but CC work_fzrpauvhvnexhintldqhzusndm 82 36 , , , work_fzrpauvhvnexhintldqhzusndm 82 37 ultimately ultimately RB work_fzrpauvhvnexhintldqhzusndm 82 38 , , , work_fzrpauvhvnexhintldqhzusndm 82 39 a a DT work_fzrpauvhvnexhintldqhzusndm 82 40 limited limited JJ work_fzrpauvhvnexhintldqhzusndm 82 41 number number NN work_fzrpauvhvnexhintldqhzusndm 82 42 of of IN work_fzrpauvhvnexhintldqhzusndm 82 43 core core NN work_fzrpauvhvnexhintldqhzusndm 82 44 pathways pathway NNS work_fzrpauvhvnexhintldqhzusndm 82 45 control control VBP work_fzrpauvhvnexhintldqhzusndm 82 46 everything everything NN work_fzrpauvhvnexhintldqhzusndm 82 47 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 82 48 26,27 26,27 CD work_fzrpauvhvnexhintldqhzusndm 82 49 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 82 50 . . . work_fzrpauvhvnexhintldqhzusndm 83 1 4 4 LS work_fzrpauvhvnexhintldqhzusndm 83 2 . . . work_fzrpauvhvnexhintldqhzusndm 84 1 Utilizing utilize VBG work_fzrpauvhvnexhintldqhzusndm 84 2 Systems Systems NNPS work_fzrpauvhvnexhintldqhzusndm 84 3 Biology Biology NNP work_fzrpauvhvnexhintldqhzusndm 84 4 Approaches Approaches NNP work_fzrpauvhvnexhintldqhzusndm 84 5 for for IN work_fzrpauvhvnexhintldqhzusndm 84 6 Very very RB work_fzrpauvhvnexhintldqhzusndm 84 7 Early Early NNP work_fzrpauvhvnexhintldqhzusndm 84 8 Prediction Prediction NNP work_fzrpauvhvnexhintldqhzusndm 84 9 and and CC work_fzrpauvhvnexhintldqhzusndm 84 10 Intervention Intervention NNP work_fzrpauvhvnexhintldqhzusndm 84 11 for for IN work_fzrpauvhvnexhintldqhzusndm 84 12 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 84 13 - - HYPH work_fzrpauvhvnexhintldqhzusndm 84 14 Mediated mediate VBN work_fzrpauvhvnexhintldqhzusndm 84 15 Diseases Diseases NNP work_fzrpauvhvnexhintldqhzusndm 84 16 Very very RB work_fzrpauvhvnexhintldqhzusndm 84 17 early early JJ work_fzrpauvhvnexhintldqhzusndm 84 18 identification identification NN work_fzrpauvhvnexhintldqhzusndm 84 19 of of IN work_fzrpauvhvnexhintldqhzusndm 84 20 high high JJ work_fzrpauvhvnexhintldqhzusndm 84 21 - - HYPH work_fzrpauvhvnexhintldqhzusndm 84 22 risk risk NN work_fzrpauvhvnexhintldqhzusndm 84 23 children child NNS work_fzrpauvhvnexhintldqhzusndm 84 24 before before IN work_fzrpauvhvnexhintldqhzusndm 84 25 they -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 84 26 develop develop VBP work_fzrpauvhvnexhintldqhzusndm 84 27 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 84 28 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 84 29 is be VBZ work_fzrpauvhvnexhintldqhzusndm 84 30 extremely extremely RB work_fzrpauvhvnexhintldqhzusndm 84 31 challenging challenging JJ work_fzrpauvhvnexhintldqhzusndm 84 32 because because IN work_fzrpauvhvnexhintldqhzusndm 84 33 of of IN work_fzrpauvhvnexhintldqhzusndm 84 34 the the DT work_fzrpauvhvnexhintldqhzusndm 84 35 multitude multitude NN work_fzrpauvhvnexhintldqhzusndm 84 36 of of IN work_fzrpauvhvnexhintldqhzusndm 84 37 contributory contributory JJ work_fzrpauvhvnexhintldqhzusndm 84 38 genetic genetic JJ work_fzrpauvhvnexhintldqhzusndm 84 39 , , , work_fzrpauvhvnexhintldqhzusndm 84 40 environmental environmental JJ work_fzrpauvhvnexhintldqhzusndm 84 41 , , , work_fzrpauvhvnexhintldqhzusndm 84 42 and and CC work_fzrpauvhvnexhintldqhzusndm 84 43 lifestyle lifestyle NN work_fzrpauvhvnexhintldqhzusndm 84 44 factors factor NNS work_fzrpauvhvnexhintldqhzusndm 84 45 . . . work_fzrpauvhvnexhintldqhzusndm 85 1 Recent recent JJ work_fzrpauvhvnexhintldqhzusndm 85 2 foundational foundational JJ work_fzrpauvhvnexhintldqhzusndm 85 3 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 85 4 studies study NNS work_fzrpauvhvnexhintldqhzusndm 85 5 have have VBP work_fzrpauvhvnexhintldqhzusndm 85 6 begun begin VBN work_fzrpauvhvnexhintldqhzusndm 85 7 to to TO work_fzrpauvhvnexhintldqhzusndm 85 8 pioneer pioneer VB work_fzrpauvhvnexhintldqhzusndm 85 9 the the DT work_fzrpauvhvnexhintldqhzusndm 85 10 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 85 11 to to TO work_fzrpauvhvnexhintldqhzusndm 85 12 identify identify VB work_fzrpauvhvnexhintldqhzusndm 85 13 disease disease NN work_fzrpauvhvnexhintldqhzusndm 85 14 and and CC work_fzrpauvhvnexhintldqhzusndm 85 15 transitions transition NNS work_fzrpauvhvnexhintldqhzusndm 85 16 and and CC work_fzrpauvhvnexhintldqhzusndm 85 17 intervene intervene VB work_fzrpauvhvnexhintldqhzusndm 85 18 early early RB work_fzrpauvhvnexhintldqhzusndm 85 19 . . . work_fzrpauvhvnexhintldqhzusndm 86 1 In in IN work_fzrpauvhvnexhintldqhzusndm 86 2 a a DT work_fzrpauvhvnexhintldqhzusndm 86 3 landmark landmark JJ work_fzrpauvhvnexhintldqhzusndm 86 4 study study NN work_fzrpauvhvnexhintldqhzusndm 86 5 , , , work_fzrpauvhvnexhintldqhzusndm 86 6 Price Price NNP work_fzrpauvhvnexhintldqhzusndm 86 7 et et NNP work_fzrpauvhvnexhintldqhzusndm 86 8 al al NNP work_fzrpauvhvnexhintldqhzusndm 86 9 . . . work_fzrpauvhvnexhintldqhzusndm 87 1 followed follow VBD work_fzrpauvhvnexhintldqhzusndm 87 2 108 108 CD work_fzrpauvhvnexhintldqhzusndm 87 3 healthy healthy JJ work_fzrpauvhvnexhintldqhzusndm 87 4 adults adult NNS work_fzrpauvhvnexhintldqhzusndm 87 5 for for IN work_fzrpauvhvnexhintldqhzusndm 87 6 nine nine CD work_fzrpauvhvnexhintldqhzusndm 87 7 months month NNS work_fzrpauvhvnexhintldqhzusndm 87 8 , , , work_fzrpauvhvnexhintldqhzusndm 87 9 and and CC work_fzrpauvhvnexhintldqhzusndm 87 10 collected collect VBN work_fzrpauvhvnexhintldqhzusndm 87 11 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 87 12 samples sample NNS work_fzrpauvhvnexhintldqhzusndm 87 13 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 87 14 saliva saliva NN work_fzrpauvhvnexhintldqhzusndm 87 15 , , , work_fzrpauvhvnexhintldqhzusndm 87 16 blood blood NN work_fzrpauvhvnexhintldqhzusndm 87 17 , , , work_fzrpauvhvnexhintldqhzusndm 87 18 urine urine NN work_fzrpauvhvnexhintldqhzusndm 87 19 , , , work_fzrpauvhvnexhintldqhzusndm 87 20 stool stool NN work_fzrpauvhvnexhintldqhzusndm 87 21 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 87 22 every every DT work_fzrpauvhvnexhintldqhzusndm 87 23 three three CD work_fzrpauvhvnexhintldqhzusndm 87 24 months month NNS work_fzrpauvhvnexhintldqhzusndm 87 25 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 87 26 26 26 CD work_fzrpauvhvnexhintldqhzusndm 87 27 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 87 28 . . . work_fzrpauvhvnexhintldqhzusndm 88 1 Multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 88 2 profiles profile NNS work_fzrpauvhvnexhintldqhzusndm 88 3 were be VBD work_fzrpauvhvnexhintldqhzusndm 88 4 generated generate VBN work_fzrpauvhvnexhintldqhzusndm 88 5 , , , work_fzrpauvhvnexhintldqhzusndm 88 6 which which WDT work_fzrpauvhvnexhintldqhzusndm 88 7 included include VBD work_fzrpauvhvnexhintldqhzusndm 88 8 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 88 9 genome genome JJ work_fzrpauvhvnexhintldqhzusndm 88 10 sequencing sequencing NN work_fzrpauvhvnexhintldqhzusndm 88 11 , , , work_fzrpauvhvnexhintldqhzusndm 88 12 16S 16s CD work_fzrpauvhvnexhintldqhzusndm 88 13 rRNA rrna NN work_fzrpauvhvnexhintldqhzusndm 88 14 gut gut NNP work_fzrpauvhvnexhintldqhzusndm 88 15 microbiome microbiome NNP work_fzrpauvhvnexhintldqhzusndm 88 16 sequencing sequencing NNP work_fzrpauvhvnexhintldqhzusndm 88 17 , , , work_fzrpauvhvnexhintldqhzusndm 88 18 218 218 CD work_fzrpauvhvnexhintldqhzusndm 88 19 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 88 20 diagnostic diagnostic JJ work_fzrpauvhvnexhintldqhzusndm 88 21 tests test NNS work_fzrpauvhvnexhintldqhzusndm 88 22 , , , work_fzrpauvhvnexhintldqhzusndm 88 23 262 262 CD work_fzrpauvhvnexhintldqhzusndm 88 24 proteins protein NNS work_fzrpauvhvnexhintldqhzusndm 88 25 , , , work_fzrpauvhvnexhintldqhzusndm 88 26 and and CC work_fzrpauvhvnexhintldqhzusndm 88 27 643 643 CD work_fzrpauvhvnexhintldqhzusndm 88 28 metabolites metabolite NNS work_fzrpauvhvnexhintldqhzusndm 88 29 . . . work_fzrpauvhvnexhintldqhzusndm 89 1 The the DT work_fzrpauvhvnexhintldqhzusndm 89 2 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 89 3 assays assays RB work_fzrpauvhvnexhintldqhzusndm 89 4 were be VBD work_fzrpauvhvnexhintldqhzusndm 89 5 designed design VBN work_fzrpauvhvnexhintldqhzusndm 89 6 to to TO work_fzrpauvhvnexhintldqhzusndm 89 7 assess assess VB work_fzrpauvhvnexhintldqhzusndm 89 8 five five CD work_fzrpauvhvnexhintldqhzusndm 89 9 health health NN work_fzrpauvhvnexhintldqhzusndm 89 10 domains domain NNS work_fzrpauvhvnexhintldqhzusndm 89 11 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 89 12 cardiovascular cardiovascular JJ work_fzrpauvhvnexhintldqhzusndm 89 13 , , , work_fzrpauvhvnexhintldqhzusndm 89 14 diabetes diabetes NN work_fzrpauvhvnexhintldqhzusndm 89 15 , , , work_fzrpauvhvnexhintldqhzusndm 89 16 inflammation inflammation NN work_fzrpauvhvnexhintldqhzusndm 89 17 , , , work_fzrpauvhvnexhintldqhzusndm 89 18 nutrition nutrition NN work_fzrpauvhvnexhintldqhzusndm 89 19 and and CC work_fzrpauvhvnexhintldqhzusndm 89 20 toxins toxin NNS work_fzrpauvhvnexhintldqhzusndm 89 21 , , , work_fzrpauvhvnexhintldqhzusndm 89 22 stress stress NN work_fzrpauvhvnexhintldqhzusndm 89 23 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 89 24 . . . work_fzrpauvhvnexhintldqhzusndm 90 1 The the DT work_fzrpauvhvnexhintldqhzusndm 90 2 genome genome JJ work_fzrpauvhvnexhintldqhzusndm 90 3 sequencing sequencing NN work_fzrpauvhvnexhintldqhzusndm 90 4 data datum NNS work_fzrpauvhvnexhintldqhzusndm 90 5 was be VBD work_fzrpauvhvnexhintldqhzusndm 90 6 summarized summarize VBN work_fzrpauvhvnexhintldqhzusndm 90 7 into into IN work_fzrpauvhvnexhintldqhzusndm 90 8 polygenic polygenic JJ work_fzrpauvhvnexhintldqhzusndm 90 9 risk risk NN work_fzrpauvhvnexhintldqhzusndm 90 10 scores score NNS work_fzrpauvhvnexhintldqhzusndm 90 11 for for IN work_fzrpauvhvnexhintldqhzusndm 90 12 127 127 CD work_fzrpauvhvnexhintldqhzusndm 90 13 disease disease NN work_fzrpauvhvnexhintldqhzusndm 90 14 traits trait NNS work_fzrpauvhvnexhintldqhzusndm 90 15 . . . work_fzrpauvhvnexhintldqhzusndm 91 1 These these DT work_fzrpauvhvnexhintldqhzusndm 91 2 risk risk NN work_fzrpauvhvnexhintldqhzusndm 91 3 scores score NNS work_fzrpauvhvnexhintldqhzusndm 91 4 are be VBP work_fzrpauvhvnexhintldqhzusndm 91 5 a a DT work_fzrpauvhvnexhintldqhzusndm 91 6 single single JJ work_fzrpauvhvnexhintldqhzusndm 91 7 variable variable NN work_fzrpauvhvnexhintldqhzusndm 91 8 that that WDT work_fzrpauvhvnexhintldqhzusndm 91 9 estimates estimate VBZ work_fzrpauvhvnexhintldqhzusndm 91 10 the the DT work_fzrpauvhvnexhintldqhzusndm 91 11 genome genome NN work_fzrpauvhvnexhintldqhzusndm 91 12 - - HYPH work_fzrpauvhvnexhintldqhzusndm 91 13 wide wide JJ work_fzrpauvhvnexhintldqhzusndm 91 14 risk risk NN work_fzrpauvhvnexhintldqhzusndm 91 15 for for IN work_fzrpauvhvnexhintldqhzusndm 91 16 a a DT work_fzrpauvhvnexhintldqhzusndm 91 17 given give VBN work_fzrpauvhvnexhintldqhzusndm 91 18 trait trait NN work_fzrpauvhvnexhintldqhzusndm 91 19 by by IN work_fzrpauvhvnexhintldqhzusndm 91 20 summing sum VBG work_fzrpauvhvnexhintldqhzusndm 91 21 the the DT work_fzrpauvhvnexhintldqhzusndm 91 22 number number NN work_fzrpauvhvnexhintldqhzusndm 91 23 of of IN work_fzrpauvhvnexhintldqhzusndm 91 24 risk risk NN work_fzrpauvhvnexhintldqhzusndm 91 25 alleles allele NNS work_fzrpauvhvnexhintldqhzusndm 91 26 for for IN work_fzrpauvhvnexhintldqhzusndm 91 27 each each DT work_fzrpauvhvnexhintldqhzusndm 91 28 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 91 29 , , , work_fzrpauvhvnexhintldqhzusndm 91 30 weighted weight VBN work_fzrpauvhvnexhintldqhzusndm 91 31 by by IN work_fzrpauvhvnexhintldqhzusndm 91 32 effect effect NN work_fzrpauvhvnexhintldqhzusndm 91 33 size size NN work_fzrpauvhvnexhintldqhzusndm 91 34 estimates estimate NNS work_fzrpauvhvnexhintldqhzusndm 91 35 from from IN work_fzrpauvhvnexhintldqhzusndm 91 36 large large JJ work_fzrpauvhvnexhintldqhzusndm 91 37 genome genome NN work_fzrpauvhvnexhintldqhzusndm 91 38 - - HYPH work_fzrpauvhvnexhintldqhzusndm 91 39 wide wide JJ work_fzrpauvhvnexhintldqhzusndm 91 40 association association NN work_fzrpauvhvnexhintldqhzusndm 91 41 studies study NNS work_fzrpauvhvnexhintldqhzusndm 91 42 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 91 43 GWAS GWAS NNP work_fzrpauvhvnexhintldqhzusndm 91 44 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 91 45 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 91 46 27 27 CD work_fzrpauvhvnexhintldqhzusndm 91 47 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 91 48 . . . work_fzrpauvhvnexhintldqhzusndm 92 1 The the DT work_fzrpauvhvnexhintldqhzusndm 92 2 data datum NNS work_fzrpauvhvnexhintldqhzusndm 92 3 were be VBD work_fzrpauvhvnexhintldqhzusndm 92 4 integrated integrate VBN work_fzrpauvhvnexhintldqhzusndm 92 5 by by IN work_fzrpauvhvnexhintldqhzusndm 92 6 constructing construct VBG work_fzrpauvhvnexhintldqhzusndm 92 7 an an DT work_fzrpauvhvnexhintldqhzusndm 92 8 interomic interomic JJ work_fzrpauvhvnexhintldqhzusndm 92 9 correlation correlation NN work_fzrpauvhvnexhintldqhzusndm 92 10 network network NN work_fzrpauvhvnexhintldqhzusndm 92 11 , , , work_fzrpauvhvnexhintldqhzusndm 92 12 which which WDT work_fzrpauvhvnexhintldqhzusndm 92 13 captures capture VBZ work_fzrpauvhvnexhintldqhzusndm 92 14 pairwise pairwise VBP work_fzrpauvhvnexhintldqhzusndm 92 15 interrelationships interrelationship VBZ work_fzrpauvhvnexhintldqhzusndm 92 16 between between IN work_fzrpauvhvnexhintldqhzusndm 92 17 the the DT work_fzrpauvhvnexhintldqhzusndm 92 18 five five CD work_fzrpauvhvnexhintldqhzusndm 92 19 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 92 20 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 92 21 . . . work_fzrpauvhvnexhintldqhzusndm 93 1 The the DT work_fzrpauvhvnexhintldqhzusndm 93 2 α α NNP work_fzrpauvhvnexhintldqhzusndm 93 3 - - HYPH work_fzrpauvhvnexhintldqhzusndm 93 4 diversity diversity NN work_fzrpauvhvnexhintldqhzusndm 93 5 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 93 6 species species NN work_fzrpauvhvnexhintldqhzusndm 93 7 richness richness NN work_fzrpauvhvnexhintldqhzusndm 93 8 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 93 9 of of IN work_fzrpauvhvnexhintldqhzusndm 93 10 the the DT work_fzrpauvhvnexhintldqhzusndm 93 11 gut gut NNP work_fzrpauvhvnexhintldqhzusndm 93 12 microbiome microbiome NNP work_fzrpauvhvnexhintldqhzusndm 93 13 was be VBD work_fzrpauvhvnexhintldqhzusndm 93 14 positively positively RB work_fzrpauvhvnexhintldqhzusndm 93 15 correlated correlate VBN work_fzrpauvhvnexhintldqhzusndm 93 16 with with IN work_fzrpauvhvnexhintldqhzusndm 93 17 height height NN work_fzrpauvhvnexhintldqhzusndm 93 18 and and CC work_fzrpauvhvnexhintldqhzusndm 93 19 β β NN work_fzrpauvhvnexhintldqhzusndm 93 20 - - HYPH work_fzrpauvhvnexhintldqhzusndm 93 21 nerve nerve NNP work_fzrpauvhvnexhintldqhzusndm 93 22 growth growth NN work_fzrpauvhvnexhintldqhzusndm 93 23 factor factor NN work_fzrpauvhvnexhintldqhzusndm 93 24 levels level NNS work_fzrpauvhvnexhintldqhzusndm 93 25 , , , work_fzrpauvhvnexhintldqhzusndm 93 26 and and CC work_fzrpauvhvnexhintldqhzusndm 93 27 negatively negatively RB work_fzrpauvhvnexhintldqhzusndm 93 28 correlated correlate VBD work_fzrpauvhvnexhintldqhzusndm 93 29 with with IN work_fzrpauvhvnexhintldqhzusndm 93 30 levels level NNS work_fzrpauvhvnexhintldqhzusndm 93 31 of of IN work_fzrpauvhvnexhintldqhzusndm 93 32 CSF-1 CSF-1 NNP work_fzrpauvhvnexhintldqhzusndm 93 33 , , , work_fzrpauvhvnexhintldqhzusndm 93 34 IL-8 IL-8 NNP work_fzrpauvhvnexhintldqhzusndm 93 35 , , , work_fzrpauvhvnexhintldqhzusndm 93 36 and and CC work_fzrpauvhvnexhintldqhzusndm 93 37 FLT3 FLT3 NNP work_fzrpauvhvnexhintldqhzusndm 93 38 ligand ligand NN work_fzrpauvhvnexhintldqhzusndm 93 39 . . . work_fzrpauvhvnexhintldqhzusndm 94 1 Clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 94 2 diagnostic diagnostic JJ work_fzrpauvhvnexhintldqhzusndm 94 3 tests test NNS work_fzrpauvhvnexhintldqhzusndm 94 4 identified identify VBD work_fzrpauvhvnexhintldqhzusndm 94 5 deviations deviation NNS work_fzrpauvhvnexhintldqhzusndm 94 6 from from IN work_fzrpauvhvnexhintldqhzusndm 94 7 wellness wellness NN work_fzrpauvhvnexhintldqhzusndm 94 8 or or CC work_fzrpauvhvnexhintldqhzusndm 94 9 test test NN work_fzrpauvhvnexhintldqhzusndm 94 10 results result NNS work_fzrpauvhvnexhintldqhzusndm 94 11 outside outside RB work_fzrpauvhvnexhintldqhzusndm 94 12 of of IN work_fzrpauvhvnexhintldqhzusndm 94 13 normal normal JJ work_fzrpauvhvnexhintldqhzusndm 94 14 reference reference NN work_fzrpauvhvnexhintldqhzusndm 94 15 ranges range VBZ work_fzrpauvhvnexhintldqhzusndm 94 16 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 94 17 28 28 CD work_fzrpauvhvnexhintldqhzusndm 94 18 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 94 19 . . . work_fzrpauvhvnexhintldqhzusndm 95 1 These these DT work_fzrpauvhvnexhintldqhzusndm 95 2 insights insight NNS work_fzrpauvhvnexhintldqhzusndm 95 3 were be VBD work_fzrpauvhvnexhintldqhzusndm 95 4 then then RB work_fzrpauvhvnexhintldqhzusndm 95 5 leveraged leverage VBN work_fzrpauvhvnexhintldqhzusndm 95 6 to to TO work_fzrpauvhvnexhintldqhzusndm 95 7 suggest suggest VB work_fzrpauvhvnexhintldqhzusndm 95 8 evidence evidence NN work_fzrpauvhvnexhintldqhzusndm 95 9 - - HYPH work_fzrpauvhvnexhintldqhzusndm 95 10 based base VBN work_fzrpauvhvnexhintldqhzusndm 95 11 changes change NNS work_fzrpauvhvnexhintldqhzusndm 95 12 to to IN work_fzrpauvhvnexhintldqhzusndm 95 13 diet diet NNP work_fzrpauvhvnexhintldqhzusndm 95 14 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 95 15 including include VBG work_fzrpauvhvnexhintldqhzusndm 95 16 supplements supplement NNS work_fzrpauvhvnexhintldqhzusndm 95 17 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 95 18 and and CC work_fzrpauvhvnexhintldqhzusndm 95 19 lifestyle lifestyle NNP work_fzrpauvhvnexhintldqhzusndm 95 20 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 95 21 exercise exercise NN work_fzrpauvhvnexhintldqhzusndm 95 22 , , , work_fzrpauvhvnexhintldqhzusndm 95 23 stress stress NN work_fzrpauvhvnexhintldqhzusndm 95 24 management management NN work_fzrpauvhvnexhintldqhzusndm 95 25 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 95 26 that that WDT work_fzrpauvhvnexhintldqhzusndm 95 27 resulted result VBD work_fzrpauvhvnexhintldqhzusndm 95 28 in in IN work_fzrpauvhvnexhintldqhzusndm 95 29 significant significant JJ work_fzrpauvhvnexhintldqhzusndm 95 30 improvements improvement NNS work_fzrpauvhvnexhintldqhzusndm 95 31 to to TO work_fzrpauvhvnexhintldqhzusndm 95 32 biomarker biomarker VB work_fzrpauvhvnexhintldqhzusndm 95 33 levels level NNS work_fzrpauvhvnexhintldqhzusndm 95 34 across across IN work_fzrpauvhvnexhintldqhzusndm 95 35 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 95 36 health health NN work_fzrpauvhvnexhintldqhzusndm 95 37 domains domain NNS work_fzrpauvhvnexhintldqhzusndm 95 38 — — : work_fzrpauvhvnexhintldqhzusndm 95 39 type type NN work_fzrpauvhvnexhintldqhzusndm 95 40 2 2 CD work_fzrpauvhvnexhintldqhzusndm 95 41 diabetes diabetes NN work_fzrpauvhvnexhintldqhzusndm 95 42 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 95 43 fasting fast VBG work_fzrpauvhvnexhintldqhzusndm 95 44 glucose glucose NN work_fzrpauvhvnexhintldqhzusndm 95 45 , , , work_fzrpauvhvnexhintldqhzusndm 95 46 HbA1c HbA1c NNP work_fzrpauvhvnexhintldqhzusndm 95 47 levels level NNS work_fzrpauvhvnexhintldqhzusndm 95 48 , , , work_fzrpauvhvnexhintldqhzusndm 95 49 insulin insulin NN work_fzrpauvhvnexhintldqhzusndm 95 50 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 95 51 , , , work_fzrpauvhvnexhintldqhzusndm 95 52 cardiovascular cardiovascular JJ work_fzrpauvhvnexhintldqhzusndm 95 53 disease disease NN work_fzrpauvhvnexhintldqhzusndm 95 54 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 95 55 total total JJ work_fzrpauvhvnexhintldqhzusndm 95 56 cholesterol cholesterol NN work_fzrpauvhvnexhintldqhzusndm 95 57 , , , work_fzrpauvhvnexhintldqhzusndm 95 58 LDL LDL NNP work_fzrpauvhvnexhintldqhzusndm 95 59 cholesterol cholesterol NN work_fzrpauvhvnexhintldqhzusndm 95 60 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 95 61 , , , work_fzrpauvhvnexhintldqhzusndm 95 62 inflammation inflammation NN work_fzrpauvhvnexhintldqhzusndm 95 63 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 95 64 IL-8 IL-8 NNP work_fzrpauvhvnexhintldqhzusndm 95 65 , , , work_fzrpauvhvnexhintldqhzusndm 95 66 TNF TNF NNP work_fzrpauvhvnexhintldqhzusndm 95 67 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 95 68 , , , work_fzrpauvhvnexhintldqhzusndm 95 69 and and CC work_fzrpauvhvnexhintldqhzusndm 95 70 toxins toxins NNP work_fzrpauvhvnexhintldqhzusndm 95 71 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 95 72 mercury mercury NN work_fzrpauvhvnexhintldqhzusndm 95 73 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 95 74 . . . work_fzrpauvhvnexhintldqhzusndm 96 1 Chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 96 2 obstructive obstructive JJ work_fzrpauvhvnexhintldqhzusndm 96 3 pulmonary pulmonary JJ work_fzrpauvhvnexhintldqhzusndm 96 4 disorder disorder NN work_fzrpauvhvnexhintldqhzusndm 96 5 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 96 6 COPD COPD NNP work_fzrpauvhvnexhintldqhzusndm 96 7 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 96 8 is be VBZ work_fzrpauvhvnexhintldqhzusndm 96 9 a a DT work_fzrpauvhvnexhintldqhzusndm 96 10 highly highly RB work_fzrpauvhvnexhintldqhzusndm 96 11 heterogeneous heterogeneous JJ work_fzrpauvhvnexhintldqhzusndm 96 12 , , , work_fzrpauvhvnexhintldqhzusndm 96 13 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 96 14 , , , work_fzrpauvhvnexhintldqhzusndm 96 15 inflammatory inflammatory JJ work_fzrpauvhvnexhintldqhzusndm 96 16 lung lung NN work_fzrpauvhvnexhintldqhzusndm 96 17 disease disease NN work_fzrpauvhvnexhintldqhzusndm 96 18 which which WDT work_fzrpauvhvnexhintldqhzusndm 96 19 has have VBZ work_fzrpauvhvnexhintldqhzusndm 96 20 early early JJ work_fzrpauvhvnexhintldqhzusndm 96 21 life life NN work_fzrpauvhvnexhintldqhzusndm 96 22 origins origin NNS work_fzrpauvhvnexhintldqhzusndm 96 23 in in IN work_fzrpauvhvnexhintldqhzusndm 96 24 a a DT work_fzrpauvhvnexhintldqhzusndm 96 25 subset subset NN work_fzrpauvhvnexhintldqhzusndm 96 26 of of IN work_fzrpauvhvnexhintldqhzusndm 96 27 patients patient NNS work_fzrpauvhvnexhintldqhzusndm 96 28 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 96 29 29 29 CD work_fzrpauvhvnexhintldqhzusndm 96 30 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 96 31 . . . work_fzrpauvhvnexhintldqhzusndm 97 1 In in IN work_fzrpauvhvnexhintldqhzusndm 97 2 a a DT work_fzrpauvhvnexhintldqhzusndm 97 3 proof proof NN work_fzrpauvhvnexhintldqhzusndm 97 4 - - HYPH work_fzrpauvhvnexhintldqhzusndm 97 5 of of IN work_fzrpauvhvnexhintldqhzusndm 97 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 97 7 concept concept NN work_fzrpauvhvnexhintldqhzusndm 97 8 study study NN work_fzrpauvhvnexhintldqhzusndm 97 9 , , , work_fzrpauvhvnexhintldqhzusndm 97 10 Li Li NNP work_fzrpauvhvnexhintldqhzusndm 97 11 et et NNP work_fzrpauvhvnexhintldqhzusndm 97 12 al al NNP work_fzrpauvhvnexhintldqhzusndm 97 13 . . . work_fzrpauvhvnexhintldqhzusndm 98 1 evaluated evaluate VBD work_fzrpauvhvnexhintldqhzusndm 98 2 the the DT work_fzrpauvhvnexhintldqhzusndm 98 3 utility utility NN work_fzrpauvhvnexhintldqhzusndm 98 4 of of IN work_fzrpauvhvnexhintldqhzusndm 98 5 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 98 6 data datum NNS work_fzrpauvhvnexhintldqhzusndm 98 7 to to TO work_fzrpauvhvnexhintldqhzusndm 98 8 differentiate differentiate VB work_fzrpauvhvnexhintldqhzusndm 98 9 between between IN work_fzrpauvhvnexhintldqhzusndm 98 10 COPD COPD NNP work_fzrpauvhvnexhintldqhzusndm 98 11 patients patient NNS work_fzrpauvhvnexhintldqhzusndm 98 12 , , , work_fzrpauvhvnexhintldqhzusndm 98 13 healthy healthy JJ work_fzrpauvhvnexhintldqhzusndm 98 14 non non NNS work_fzrpauvhvnexhintldqhzusndm 98 15 - - JJ work_fzrpauvhvnexhintldqhzusndm 98 16 smokers smoker NNS work_fzrpauvhvnexhintldqhzusndm 98 17 , , , work_fzrpauvhvnexhintldqhzusndm 98 18 and and CC work_fzrpauvhvnexhintldqhzusndm 98 19 smokers smoker NNS work_fzrpauvhvnexhintldqhzusndm 98 20 with with IN work_fzrpauvhvnexhintldqhzusndm 98 21 normal normal JJ work_fzrpauvhvnexhintldqhzusndm 98 22 lung lung NN work_fzrpauvhvnexhintldqhzusndm 98 23 function function NN work_fzrpauvhvnexhintldqhzusndm 98 24 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 98 25 5 5 CD work_fzrpauvhvnexhintldqhzusndm 98 26 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 98 27 . . . work_fzrpauvhvnexhintldqhzusndm 99 1 They -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 99 2 found find VBD work_fzrpauvhvnexhintldqhzusndm 99 3 that that IN work_fzrpauvhvnexhintldqhzusndm 99 4 the the DT work_fzrpauvhvnexhintldqhzusndm 99 5 mean mean JJ work_fzrpauvhvnexhintldqhzusndm 99 6 accuracy accuracy NN work_fzrpauvhvnexhintldqhzusndm 99 7 of of IN work_fzrpauvhvnexhintldqhzusndm 99 8 subgroup subgroup NN work_fzrpauvhvnexhintldqhzusndm 99 9 prediction prediction NN work_fzrpauvhvnexhintldqhzusndm 99 10 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 99 11 healthy healthy JJ work_fzrpauvhvnexhintldqhzusndm 99 12 , , , work_fzrpauvhvnexhintldqhzusndm 99 13 smoker smoker NN work_fzrpauvhvnexhintldqhzusndm 99 14 , , , work_fzrpauvhvnexhintldqhzusndm 99 15 COPD COPD NNP work_fzrpauvhvnexhintldqhzusndm 99 16 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 99 17 was be VBD work_fzrpauvhvnexhintldqhzusndm 99 18 extremely extremely RB work_fzrpauvhvnexhintldqhzusndm 99 19 poor poor JJ work_fzrpauvhvnexhintldqhzusndm 99 20 when when WRB work_fzrpauvhvnexhintldqhzusndm 99 21 each each DT work_fzrpauvhvnexhintldqhzusndm 99 22 of of IN work_fzrpauvhvnexhintldqhzusndm 99 23 the the DT work_fzrpauvhvnexhintldqhzusndm 99 24 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 99 25 data datum NNS work_fzrpauvhvnexhintldqhzusndm 99 26 blocks block NNS work_fzrpauvhvnexhintldqhzusndm 99 27 were be VBD work_fzrpauvhvnexhintldqhzusndm 99 28 analyzed analyze VBN work_fzrpauvhvnexhintldqhzusndm 99 29 in in IN work_fzrpauvhvnexhintldqhzusndm 99 30 isolation isolation NN work_fzrpauvhvnexhintldqhzusndm 99 31 . . . work_fzrpauvhvnexhintldqhzusndm 100 1 However however RB work_fzrpauvhvnexhintldqhzusndm 100 2 , , , work_fzrpauvhvnexhintldqhzusndm 100 3 combining combine VBG work_fzrpauvhvnexhintldqhzusndm 100 4 data datum NNS work_fzrpauvhvnexhintldqhzusndm 100 5 from from IN work_fzrpauvhvnexhintldqhzusndm 100 6 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 100 7 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 100 8 platforms platform NNS work_fzrpauvhvnexhintldqhzusndm 100 9 increased increase VBD work_fzrpauvhvnexhintldqhzusndm 100 10 the the DT work_fzrpauvhvnexhintldqhzusndm 100 11 mean mean JJ work_fzrpauvhvnexhintldqhzusndm 100 12 prediction prediction NN work_fzrpauvhvnexhintldqhzusndm 100 13 accuracy accuracy NN work_fzrpauvhvnexhintldqhzusndm 100 14 to to IN work_fzrpauvhvnexhintldqhzusndm 100 15 100 100 CD work_fzrpauvhvnexhintldqhzusndm 100 16 % % NN work_fzrpauvhvnexhintldqhzusndm 100 17 , , , work_fzrpauvhvnexhintldqhzusndm 100 18 even even RB work_fzrpauvhvnexhintldqhzusndm 100 19 when when WRB work_fzrpauvhvnexhintldqhzusndm 100 20 group group NN work_fzrpauvhvnexhintldqhzusndm 100 21 sizes size NNS work_fzrpauvhvnexhintldqhzusndm 100 22 were be VBD work_fzrpauvhvnexhintldqhzusndm 100 23 limited limit VBN work_fzrpauvhvnexhintldqhzusndm 100 24 to to IN work_fzrpauvhvnexhintldqhzusndm 100 25 small small JJ work_fzrpauvhvnexhintldqhzusndm 100 26 numbers number NNS work_fzrpauvhvnexhintldqhzusndm 100 27 . . . work_fzrpauvhvnexhintldqhzusndm 101 1 These these DT work_fzrpauvhvnexhintldqhzusndm 101 2 analyses analysis NNS work_fzrpauvhvnexhintldqhzusndm 101 3 highlight highlight VBP work_fzrpauvhvnexhintldqhzusndm 101 4 the the DT work_fzrpauvhvnexhintldqhzusndm 101 5 potential potential NN work_fzrpauvhvnexhintldqhzusndm 101 6 for for IN work_fzrpauvhvnexhintldqhzusndm 101 7 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 101 8 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 101 9 to to TO work_fzrpauvhvnexhintldqhzusndm 101 10 dramatically dramatically RB work_fzrpauvhvnexhintldqhzusndm 101 11 improve improve VB work_fzrpauvhvnexhintldqhzusndm 101 12 our -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 101 13 understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 101 14 of of IN work_fzrpauvhvnexhintldqhzusndm 101 15 highly highly RB work_fzrpauvhvnexhintldqhzusndm 101 16 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 101 17 and and CC work_fzrpauvhvnexhintldqhzusndm 101 18 heterogeneous heterogeneous JJ work_fzrpauvhvnexhintldqhzusndm 101 19 inflammatory inflammatory JJ work_fzrpauvhvnexhintldqhzusndm 101 20 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 101 21 . . . work_fzrpauvhvnexhintldqhzusndm 102 1 Very very RB work_fzrpauvhvnexhintldqhzusndm 102 2 early early JJ work_fzrpauvhvnexhintldqhzusndm 102 3 identification identification NN work_fzrpauvhvnexhintldqhzusndm 102 4 of of IN work_fzrpauvhvnexhintldqhzusndm 102 5 at at IN work_fzrpauvhvnexhintldqhzusndm 102 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 102 7 risk risk NN work_fzrpauvhvnexhintldqhzusndm 102 8 individuals individual NNS work_fzrpauvhvnexhintldqhzusndm 102 9 from from IN work_fzrpauvhvnexhintldqhzusndm 102 10 birth birth NN work_fzrpauvhvnexhintldqhzusndm 102 11 is be VBZ work_fzrpauvhvnexhintldqhzusndm 102 12 now now RB work_fzrpauvhvnexhintldqhzusndm 102 13 theoretically theoretically RB work_fzrpauvhvnexhintldqhzusndm 102 14 possible possible JJ work_fzrpauvhvnexhintldqhzusndm 102 15 with with IN work_fzrpauvhvnexhintldqhzusndm 102 16 polygenic polygenic JJ work_fzrpauvhvnexhintldqhzusndm 102 17 risk risk NN work_fzrpauvhvnexhintldqhzusndm 102 18 scores score NNS work_fzrpauvhvnexhintldqhzusndm 102 19 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 102 20 30 30 CD work_fzrpauvhvnexhintldqhzusndm 102 21 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 102 22 . . . work_fzrpauvhvnexhintldqhzusndm 103 1 These these DT work_fzrpauvhvnexhintldqhzusndm 103 2 risk risk NN work_fzrpauvhvnexhintldqhzusndm 103 3 scores score NNS work_fzrpauvhvnexhintldqhzusndm 103 4 combine combine VBP work_fzrpauvhvnexhintldqhzusndm 103 5 information information NN work_fzrpauvhvnexhintldqhzusndm 103 6 derived derive VBN work_fzrpauvhvnexhintldqhzusndm 103 7 from from IN work_fzrpauvhvnexhintldqhzusndm 103 8 variants variant NNS work_fzrpauvhvnexhintldqhzusndm 103 9 across across IN work_fzrpauvhvnexhintldqhzusndm 103 10 the the DT work_fzrpauvhvnexhintldqhzusndm 103 11 entire entire JJ work_fzrpauvhvnexhintldqhzusndm 103 12 genome genome NN work_fzrpauvhvnexhintldqhzusndm 103 13 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 103 14 30 30 CD work_fzrpauvhvnexhintldqhzusndm 103 15 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 103 16 , , , work_fzrpauvhvnexhintldqhzusndm 103 17 and and CC work_fzrpauvhvnexhintldqhzusndm 103 18 are be VBP work_fzrpauvhvnexhintldqhzusndm 103 19 able able JJ work_fzrpauvhvnexhintldqhzusndm 103 20 to to TO work_fzrpauvhvnexhintldqhzusndm 103 21 identify identify VB work_fzrpauvhvnexhintldqhzusndm 103 22 segments segment NNS work_fzrpauvhvnexhintldqhzusndm 103 23 of of IN work_fzrpauvhvnexhintldqhzusndm 103 24 the the DT work_fzrpauvhvnexhintldqhzusndm 103 25 population population NN work_fzrpauvhvnexhintldqhzusndm 103 26 which which WDT work_fzrpauvhvnexhintldqhzusndm 103 27 are be VBP work_fzrpauvhvnexhintldqhzusndm 103 28 at at IN work_fzrpauvhvnexhintldqhzusndm 103 29 heightened heighten VBN work_fzrpauvhvnexhintldqhzusndm 103 30 risk risk NN work_fzrpauvhvnexhintldqhzusndm 103 31 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 103 32 more more JJR work_fzrpauvhvnexhintldqhzusndm 103 33 than than IN work_fzrpauvhvnexhintldqhzusndm 103 34 three three CD work_fzrpauvhvnexhintldqhzusndm 103 35 - - RB work_fzrpauvhvnexhintldqhzusndm 103 36 fold fold RB work_fzrpauvhvnexhintldqhzusndm 103 37 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 103 38 for for IN work_fzrpauvhvnexhintldqhzusndm 103 39 a a DT work_fzrpauvhvnexhintldqhzusndm 103 40 range range NN work_fzrpauvhvnexhintldqhzusndm 103 41 of of IN work_fzrpauvhvnexhintldqhzusndm 103 42 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 103 43 traits trait NNS work_fzrpauvhvnexhintldqhzusndm 103 44 including include VBG work_fzrpauvhvnexhintldqhzusndm 103 45 inflammatory inflammatory JJ work_fzrpauvhvnexhintldqhzusndm 103 46 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 103 47 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 103 48 31 31 CD work_fzrpauvhvnexhintldqhzusndm 103 49 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 103 50 . . . work_fzrpauvhvnexhintldqhzusndm 104 1 One one CD work_fzrpauvhvnexhintldqhzusndm 104 2 caveat caveat NN work_fzrpauvhvnexhintldqhzusndm 104 3 of of IN work_fzrpauvhvnexhintldqhzusndm 104 4 polygenic polygenic JJ work_fzrpauvhvnexhintldqhzusndm 104 5 risk risk NN work_fzrpauvhvnexhintldqhzusndm 104 6 scores score NNS work_fzrpauvhvnexhintldqhzusndm 104 7 is be VBZ work_fzrpauvhvnexhintldqhzusndm 104 8 that that DT work_fzrpauvhvnexhintldqhzusndm 104 9 information information NN work_fzrpauvhvnexhintldqhzusndm 104 10 is be VBZ work_fzrpauvhvnexhintldqhzusndm 104 11 collapsed collapse VBN work_fzrpauvhvnexhintldqhzusndm 104 12 across across IN work_fzrpauvhvnexhintldqhzusndm 104 13 the the DT work_fzrpauvhvnexhintldqhzusndm 104 14 genome genome NN work_fzrpauvhvnexhintldqhzusndm 104 15 without without IN work_fzrpauvhvnexhintldqhzusndm 104 16 taking take VBG work_fzrpauvhvnexhintldqhzusndm 104 17 into into IN work_fzrpauvhvnexhintldqhzusndm 104 18 account account NN work_fzrpauvhvnexhintldqhzusndm 104 19 the the DT work_fzrpauvhvnexhintldqhzusndm 104 20 cellular cellular JJ work_fzrpauvhvnexhintldqhzusndm 104 21 or or CC work_fzrpauvhvnexhintldqhzusndm 104 22 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 104 23 context context NN work_fzrpauvhvnexhintldqhzusndm 104 24 . . . work_fzrpauvhvnexhintldqhzusndm 105 1 To to TO work_fzrpauvhvnexhintldqhzusndm 105 2 address address VB work_fzrpauvhvnexhintldqhzusndm 105 3 this this DT work_fzrpauvhvnexhintldqhzusndm 105 4 issue issue NN work_fzrpauvhvnexhintldqhzusndm 105 5 , , , work_fzrpauvhvnexhintldqhzusndm 105 6 cluster cluster VBD work_fzrpauvhvnexhintldqhzusndm 105 7 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 105 8 of of IN work_fzrpauvhvnexhintldqhzusndm 105 9 deep deep JJ work_fzrpauvhvnexhintldqhzusndm 105 10 immunological immunological JJ work_fzrpauvhvnexhintldqhzusndm 105 11 and and CC work_fzrpauvhvnexhintldqhzusndm 105 12 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 105 13 data datum NNS work_fzrpauvhvnexhintldqhzusndm 105 14 can can MD work_fzrpauvhvnexhintldqhzusndm 105 15 be be VB work_fzrpauvhvnexhintldqhzusndm 105 16 utilized utilize VBN work_fzrpauvhvnexhintldqhzusndm 105 17 to to TO work_fzrpauvhvnexhintldqhzusndm 105 18 stratify stratify VB work_fzrpauvhvnexhintldqhzusndm 105 19 subjects subject NNS work_fzrpauvhvnexhintldqhzusndm 105 20 into into IN work_fzrpauvhvnexhintldqhzusndm 105 21 distinct distinct JJ work_fzrpauvhvnexhintldqhzusndm 105 22 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 105 23 trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 105 24 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 105 25 32 32 CD work_fzrpauvhvnexhintldqhzusndm 105 26 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 105 27 , , , work_fzrpauvhvnexhintldqhzusndm 105 28 and and CC work_fzrpauvhvnexhintldqhzusndm 105 29 the the DT work_fzrpauvhvnexhintldqhzusndm 105 30 polygenic polygenic JJ work_fzrpauvhvnexhintldqhzusndm 105 31 risk risk NN work_fzrpauvhvnexhintldqhzusndm 105 32 scores score NNS work_fzrpauvhvnexhintldqhzusndm 105 33 can can MD work_fzrpauvhvnexhintldqhzusndm 105 34 be be VB work_fzrpauvhvnexhintldqhzusndm 105 35 leveraged leverage VBN work_fzrpauvhvnexhintldqhzusndm 105 36 to to TO work_fzrpauvhvnexhintldqhzusndm 105 37 find find VB work_fzrpauvhvnexhintldqhzusndm 105 38 those those DT work_fzrpauvhvnexhintldqhzusndm 105 39 clusters cluster NNS work_fzrpauvhvnexhintldqhzusndm 105 40 enriched enrich VBN work_fzrpauvhvnexhintldqhzusndm 105 41 for for IN work_fzrpauvhvnexhintldqhzusndm 105 42 subjects subject NNS work_fzrpauvhvnexhintldqhzusndm 105 43 at at IN work_fzrpauvhvnexhintldqhzusndm 105 44 heightened heightened JJ work_fzrpauvhvnexhintldqhzusndm 105 45 genetic genetic JJ work_fzrpauvhvnexhintldqhzusndm 105 46 risk risk NN work_fzrpauvhvnexhintldqhzusndm 105 47 . . . work_fzrpauvhvnexhintldqhzusndm 106 1 Extending extend VBG work_fzrpauvhvnexhintldqhzusndm 106 2 this this DT work_fzrpauvhvnexhintldqhzusndm 106 3 approach approach NN work_fzrpauvhvnexhintldqhzusndm 106 4 to to IN work_fzrpauvhvnexhintldqhzusndm 106 5 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 106 6 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 106 7 will will MD work_fzrpauvhvnexhintldqhzusndm 106 8 undoubtedly undoubtedly RB work_fzrpauvhvnexhintldqhzusndm 106 9 increase increase VB work_fzrpauvhvnexhintldqhzusndm 106 10 the the DT work_fzrpauvhvnexhintldqhzusndm 106 11 resolution resolution NN work_fzrpauvhvnexhintldqhzusndm 106 12 of of IN work_fzrpauvhvnexhintldqhzusndm 106 13 these these DT work_fzrpauvhvnexhintldqhzusndm 106 14 analyses analysis NNS work_fzrpauvhvnexhintldqhzusndm 106 15 and and CC work_fzrpauvhvnexhintldqhzusndm 106 16 further further RB work_fzrpauvhvnexhintldqhzusndm 106 17 refine refine VB work_fzrpauvhvnexhintldqhzusndm 106 18 the the DT work_fzrpauvhvnexhintldqhzusndm 106 19 critical critical JJ work_fzrpauvhvnexhintldqhzusndm 106 20 windows window NNS work_fzrpauvhvnexhintldqhzusndm 106 21 of of IN work_fzrpauvhvnexhintldqhzusndm 106 22 opportunity opportunity NN work_fzrpauvhvnexhintldqhzusndm 106 23 for for IN work_fzrpauvhvnexhintldqhzusndm 106 24 early early JJ work_fzrpauvhvnexhintldqhzusndm 106 25 intervention intervention NN work_fzrpauvhvnexhintldqhzusndm 106 26 . . . work_fzrpauvhvnexhintldqhzusndm 107 1 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 107 2 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 107 3 , , , work_fzrpauvhvnexhintldqhzusndm 107 4 10 10 CD work_fzrpauvhvnexhintldqhzusndm 107 5 , , , work_fzrpauvhvnexhintldqhzusndm 107 6 23 23 CD work_fzrpauvhvnexhintldqhzusndm 107 7 5 5 CD work_fzrpauvhvnexhintldqhzusndm 107 8 of of IN work_fzrpauvhvnexhintldqhzusndm 107 9 9 9 CD work_fzrpauvhvnexhintldqhzusndm 107 10 5 5 CD work_fzrpauvhvnexhintldqhzusndm 107 11 . . . work_fzrpauvhvnexhintldqhzusndm 108 1 Multiomic Multiomic NNP work_fzrpauvhvnexhintldqhzusndm 108 2 Studies Studies NNPS work_fzrpauvhvnexhintldqhzusndm 108 3 : : : work_fzrpauvhvnexhintldqhzusndm 108 4 Challenges Challenges NNPS work_fzrpauvhvnexhintldqhzusndm 108 5 and and CC work_fzrpauvhvnexhintldqhzusndm 108 6 Opportunities opportunity NNS work_fzrpauvhvnexhintldqhzusndm 108 7 5.1 5.1 CD work_fzrpauvhvnexhintldqhzusndm 108 8 . . . work_fzrpauvhvnexhintldqhzusndm 109 1 Sample Sample NNP work_fzrpauvhvnexhintldqhzusndm 109 2 Collection Collection NNP work_fzrpauvhvnexhintldqhzusndm 109 3 Multiomic Multiomic NNP work_fzrpauvhvnexhintldqhzusndm 109 4 studies study NNS work_fzrpauvhvnexhintldqhzusndm 109 5 have have VBP work_fzrpauvhvnexhintldqhzusndm 109 6 been be VBN work_fzrpauvhvnexhintldqhzusndm 109 7 successfully successfully RB work_fzrpauvhvnexhintldqhzusndm 109 8 applied apply VBN work_fzrpauvhvnexhintldqhzusndm 109 9 to to IN work_fzrpauvhvnexhintldqhzusndm 109 10 adults adult NNS work_fzrpauvhvnexhintldqhzusndm 109 11 to to TO work_fzrpauvhvnexhintldqhzusndm 109 12 identify identify VB work_fzrpauvhvnexhintldqhzusndm 109 13 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 109 14 correlates correlate NNS work_fzrpauvhvnexhintldqhzusndm 109 15 of of IN work_fzrpauvhvnexhintldqhzusndm 109 16 disease disease NN work_fzrpauvhvnexhintldqhzusndm 109 17 risk risk NN work_fzrpauvhvnexhintldqhzusndm 109 18 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 109 19 26,33 26,33 CD work_fzrpauvhvnexhintldqhzusndm 109 20 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 109 21 . . . work_fzrpauvhvnexhintldqhzusndm 110 1 The the DT work_fzrpauvhvnexhintldqhzusndm 110 2 application application NN work_fzrpauvhvnexhintldqhzusndm 110 3 of of IN work_fzrpauvhvnexhintldqhzusndm 110 4 these these DT work_fzrpauvhvnexhintldqhzusndm 110 5 tools tool NNS work_fzrpauvhvnexhintldqhzusndm 110 6 to to IN work_fzrpauvhvnexhintldqhzusndm 110 7 early early JJ work_fzrpauvhvnexhintldqhzusndm 110 8 infancy infancy NN work_fzrpauvhvnexhintldqhzusndm 110 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 110 10 itself -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 110 11 challenging challenging JJ work_fzrpauvhvnexhintldqhzusndm 110 12 because because IN work_fzrpauvhvnexhintldqhzusndm 110 13 only only RB work_fzrpauvhvnexhintldqhzusndm 110 14 limited limited JJ work_fzrpauvhvnexhintldqhzusndm 110 15 volumes volume NNS work_fzrpauvhvnexhintldqhzusndm 110 16 of of IN work_fzrpauvhvnexhintldqhzusndm 110 17 blood blood NN work_fzrpauvhvnexhintldqhzusndm 110 18 can can MD work_fzrpauvhvnexhintldqhzusndm 110 19 be be VB work_fzrpauvhvnexhintldqhzusndm 110 20 collected collect VBN work_fzrpauvhvnexhintldqhzusndm 110 21 , , , work_fzrpauvhvnexhintldqhzusndm 110 22 and and CC work_fzrpauvhvnexhintldqhzusndm 110 23 collection collection NN work_fzrpauvhvnexhintldqhzusndm 110 24 of of IN work_fzrpauvhvnexhintldqhzusndm 110 25 fasting fast VBG work_fzrpauvhvnexhintldqhzusndm 110 26 blood blood NN work_fzrpauvhvnexhintldqhzusndm 110 27 is be VBZ work_fzrpauvhvnexhintldqhzusndm 110 28 not not RB work_fzrpauvhvnexhintldqhzusndm 110 29 feasible feasible JJ work_fzrpauvhvnexhintldqhzusndm 110 30 . . . work_fzrpauvhvnexhintldqhzusndm 111 1 Despite despite IN work_fzrpauvhvnexhintldqhzusndm 111 2 this this DT work_fzrpauvhvnexhintldqhzusndm 111 3 , , , work_fzrpauvhvnexhintldqhzusndm 111 4 protocols protocol NNS work_fzrpauvhvnexhintldqhzusndm 111 5 for for IN work_fzrpauvhvnexhintldqhzusndm 111 6 small small JJ work_fzrpauvhvnexhintldqhzusndm 111 7 volume volume NN work_fzrpauvhvnexhintldqhzusndm 111 8 collections collection NNS work_fzrpauvhvnexhintldqhzusndm 111 9 yielding yield VBG work_fzrpauvhvnexhintldqhzusndm 111 10 high high JJ work_fzrpauvhvnexhintldqhzusndm 111 11 - - HYPH work_fzrpauvhvnexhintldqhzusndm 111 12 quality quality NN work_fzrpauvhvnexhintldqhzusndm 111 13 data datum NNS work_fzrpauvhvnexhintldqhzusndm 111 14 have have VBP work_fzrpauvhvnexhintldqhzusndm 111 15 been be VBN work_fzrpauvhvnexhintldqhzusndm 111 16 developed develop VBN work_fzrpauvhvnexhintldqhzusndm 111 17 and and CC work_fzrpauvhvnexhintldqhzusndm 111 18 published publish VBN work_fzrpauvhvnexhintldqhzusndm 111 19 . . . work_fzrpauvhvnexhintldqhzusndm 112 1 A a DT work_fzrpauvhvnexhintldqhzusndm 112 2 recent recent JJ work_fzrpauvhvnexhintldqhzusndm 112 3 study study NN work_fzrpauvhvnexhintldqhzusndm 112 4 of of IN work_fzrpauvhvnexhintldqhzusndm 112 5 58 58 CD work_fzrpauvhvnexhintldqhzusndm 112 6 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 112 7 cell cell NN work_fzrpauvhvnexhintldqhzusndm 112 8 populations population NNS work_fzrpauvhvnexhintldqhzusndm 112 9 and and CC work_fzrpauvhvnexhintldqhzusndm 112 10 267 267 CD work_fzrpauvhvnexhintldqhzusndm 112 11 plasma plasma NN work_fzrpauvhvnexhintldqhzusndm 112 12 protein protein NN work_fzrpauvhvnexhintldqhzusndm 112 13 immunoassays immunoassay NNS work_fzrpauvhvnexhintldqhzusndm 112 14 was be VBD work_fzrpauvhvnexhintldqhzusndm 112 15 performed perform VBN work_fzrpauvhvnexhintldqhzusndm 112 16 on on IN work_fzrpauvhvnexhintldqhzusndm 112 17 100 100 CD work_fzrpauvhvnexhintldqhzusndm 112 18 µL µL NNP work_fzrpauvhvnexhintldqhzusndm 112 19 of of IN work_fzrpauvhvnexhintldqhzusndm 112 20 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 112 21 blood blood NN work_fzrpauvhvnexhintldqhzusndm 112 22 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 112 23 8 8 CD work_fzrpauvhvnexhintldqhzusndm 112 24 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 112 25 . . . work_fzrpauvhvnexhintldqhzusndm 113 1 Whole whole JJ work_fzrpauvhvnexhintldqhzusndm 113 2 blood blood NN work_fzrpauvhvnexhintldqhzusndm 113 3 represents represent VBZ work_fzrpauvhvnexhintldqhzusndm 113 4 a a DT work_fzrpauvhvnexhintldqhzusndm 113 5 convenient convenient JJ work_fzrpauvhvnexhintldqhzusndm 113 6 and and CC work_fzrpauvhvnexhintldqhzusndm 113 7 attractive attractive JJ work_fzrpauvhvnexhintldqhzusndm 113 8 tissue tissue NN work_fzrpauvhvnexhintldqhzusndm 113 9 for for IN work_fzrpauvhvnexhintldqhzusndm 113 10 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 113 11 studies study NNS work_fzrpauvhvnexhintldqhzusndm 113 12 that that WDT work_fzrpauvhvnexhintldqhzusndm 113 13 is be VBZ work_fzrpauvhvnexhintldqhzusndm 113 14 amenable amenable JJ work_fzrpauvhvnexhintldqhzusndm 113 15 to to TO work_fzrpauvhvnexhintldqhzusndm 113 16 fractionation fractionation VB work_fzrpauvhvnexhintldqhzusndm 113 17 into into IN work_fzrpauvhvnexhintldqhzusndm 113 18 different different JJ work_fzrpauvhvnexhintldqhzusndm 113 19 aliquots aliquot NNS work_fzrpauvhvnexhintldqhzusndm 113 20 for for IN work_fzrpauvhvnexhintldqhzusndm 113 21 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 113 22 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 113 23 platforms platform NNS work_fzrpauvhvnexhintldqhzusndm 113 24 that that WDT work_fzrpauvhvnexhintldqhzusndm 113 25 can can MD work_fzrpauvhvnexhintldqhzusndm 113 26 be be VB work_fzrpauvhvnexhintldqhzusndm 113 27 integrated integrate VBN work_fzrpauvhvnexhintldqhzusndm 113 28 following follow VBG work_fzrpauvhvnexhintldqhzusndm 113 29 data data NN work_fzrpauvhvnexhintldqhzusndm 113 30 generation generation NN work_fzrpauvhvnexhintldqhzusndm 113 31 . . . work_fzrpauvhvnexhintldqhzusndm 114 1 The the DT work_fzrpauvhvnexhintldqhzusndm 114 2 caveat caveat NN work_fzrpauvhvnexhintldqhzusndm 114 3 of of IN work_fzrpauvhvnexhintldqhzusndm 114 4 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 114 5 blood blood NN work_fzrpauvhvnexhintldqhzusndm 114 6 is be VBZ work_fzrpauvhvnexhintldqhzusndm 114 7 that that IN work_fzrpauvhvnexhintldqhzusndm 114 8 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 114 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 114 10 a a DT work_fzrpauvhvnexhintldqhzusndm 114 11 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 114 12 tissue tissue NN work_fzrpauvhvnexhintldqhzusndm 114 13 , , , work_fzrpauvhvnexhintldqhzusndm 114 14 and and CC work_fzrpauvhvnexhintldqhzusndm 114 15 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 114 16 profiles profile NNS work_fzrpauvhvnexhintldqhzusndm 114 17 therefore therefore RB work_fzrpauvhvnexhintldqhzusndm 114 18 represent represent VBP work_fzrpauvhvnexhintldqhzusndm 114 19 an an DT work_fzrpauvhvnexhintldqhzusndm 114 20 average average JJ work_fzrpauvhvnexhintldqhzusndm 114 21 profile profile NN work_fzrpauvhvnexhintldqhzusndm 114 22 across across IN work_fzrpauvhvnexhintldqhzusndm 114 23 all all DT work_fzrpauvhvnexhintldqhzusndm 114 24 cells cell NNS work_fzrpauvhvnexhintldqhzusndm 114 25 in in IN work_fzrpauvhvnexhintldqhzusndm 114 26 the the DT work_fzrpauvhvnexhintldqhzusndm 114 27 blood blood NN work_fzrpauvhvnexhintldqhzusndm 114 28 sample sample NN work_fzrpauvhvnexhintldqhzusndm 114 29 , , , work_fzrpauvhvnexhintldqhzusndm 114 30 which which WDT work_fzrpauvhvnexhintldqhzusndm 114 31 can can MD work_fzrpauvhvnexhintldqhzusndm 114 32 limit limit VB work_fzrpauvhvnexhintldqhzusndm 114 33 analyses analysis NNS work_fzrpauvhvnexhintldqhzusndm 114 34 of of IN work_fzrpauvhvnexhintldqhzusndm 114 35 cell cell NN work_fzrpauvhvnexhintldqhzusndm 114 36 specific specific JJ work_fzrpauvhvnexhintldqhzusndm 114 37 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 114 38 . . . work_fzrpauvhvnexhintldqhzusndm 115 1 Despite despite IN work_fzrpauvhvnexhintldqhzusndm 115 2 this this DT work_fzrpauvhvnexhintldqhzusndm 115 3 , , , work_fzrpauvhvnexhintldqhzusndm 115 4 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 115 5 blood blood NN work_fzrpauvhvnexhintldqhzusndm 115 6 is be VBZ work_fzrpauvhvnexhintldqhzusndm 115 7 likely likely JJ work_fzrpauvhvnexhintldqhzusndm 115 8 to to TO work_fzrpauvhvnexhintldqhzusndm 115 9 be be VB work_fzrpauvhvnexhintldqhzusndm 115 10 the the DT work_fzrpauvhvnexhintldqhzusndm 115 11 tissue tissue NN work_fzrpauvhvnexhintldqhzusndm 115 12 of of IN work_fzrpauvhvnexhintldqhzusndm 115 13 choice choice NN work_fzrpauvhvnexhintldqhzusndm 115 14 for for IN work_fzrpauvhvnexhintldqhzusndm 115 15 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 115 16 studies study NNS work_fzrpauvhvnexhintldqhzusndm 115 17 with with IN work_fzrpauvhvnexhintldqhzusndm 115 18 protocols protocol NNS work_fzrpauvhvnexhintldqhzusndm 115 19 in in IN work_fzrpauvhvnexhintldqhzusndm 115 20 development development NN work_fzrpauvhvnexhintldqhzusndm 115 21 that that WDT work_fzrpauvhvnexhintldqhzusndm 115 22 allow allow VBP work_fzrpauvhvnexhintldqhzusndm 115 23 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 115 24 profiling profiling NN work_fzrpauvhvnexhintldqhzusndm 115 25 , , , work_fzrpauvhvnexhintldqhzusndm 115 26 genetics genetic NNS work_fzrpauvhvnexhintldqhzusndm 115 27 , , , work_fzrpauvhvnexhintldqhzusndm 115 28 transcriptomics transcriptomic NNS work_fzrpauvhvnexhintldqhzusndm 115 29 , , , work_fzrpauvhvnexhintldqhzusndm 115 30 epigenetics epigenetic NNS work_fzrpauvhvnexhintldqhzusndm 115 31 , , , work_fzrpauvhvnexhintldqhzusndm 115 32 metabolomics metabolomic NNS work_fzrpauvhvnexhintldqhzusndm 115 33 , , , work_fzrpauvhvnexhintldqhzusndm 115 34 and and CC work_fzrpauvhvnexhintldqhzusndm 115 35 exposome exposome JJ work_fzrpauvhvnexhintldqhzusndm 115 36 profiling profiling NN work_fzrpauvhvnexhintldqhzusndm 115 37 from from IN work_fzrpauvhvnexhintldqhzusndm 115 38 less less JJR work_fzrpauvhvnexhintldqhzusndm 115 39 than than IN work_fzrpauvhvnexhintldqhzusndm 115 40 5 5 CD work_fzrpauvhvnexhintldqhzusndm 115 41 mL ml NN work_fzrpauvhvnexhintldqhzusndm 115 42 of of IN work_fzrpauvhvnexhintldqhzusndm 115 43 blood blood NN work_fzrpauvhvnexhintldqhzusndm 115 44 . . . work_fzrpauvhvnexhintldqhzusndm 116 1 In in IN work_fzrpauvhvnexhintldqhzusndm 116 2 order order NN work_fzrpauvhvnexhintldqhzusndm 116 3 to to TO work_fzrpauvhvnexhintldqhzusndm 116 4 ensure ensure VB work_fzrpauvhvnexhintldqhzusndm 116 5 data datum NNS work_fzrpauvhvnexhintldqhzusndm 116 6 veracity veracity NN work_fzrpauvhvnexhintldqhzusndm 116 7 , , , work_fzrpauvhvnexhintldqhzusndm 116 8 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 116 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 116 10 crucial crucial JJ work_fzrpauvhvnexhintldqhzusndm 116 11 to to TO work_fzrpauvhvnexhintldqhzusndm 116 12 stringently stringently RB work_fzrpauvhvnexhintldqhzusndm 116 13 standardize standardize VB work_fzrpauvhvnexhintldqhzusndm 116 14 the the DT work_fzrpauvhvnexhintldqhzusndm 116 15 processes process NNS work_fzrpauvhvnexhintldqhzusndm 116 16 of of IN work_fzrpauvhvnexhintldqhzusndm 116 17 sample sample NN work_fzrpauvhvnexhintldqhzusndm 116 18 preparation preparation NN work_fzrpauvhvnexhintldqhzusndm 116 19 even even RB work_fzrpauvhvnexhintldqhzusndm 116 20 before before IN work_fzrpauvhvnexhintldqhzusndm 116 21 considering consider VBG work_fzrpauvhvnexhintldqhzusndm 116 22 the the DT work_fzrpauvhvnexhintldqhzusndm 116 23 different different JJ work_fzrpauvhvnexhintldqhzusndm 116 24 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 116 25 assays assay NNS work_fzrpauvhvnexhintldqhzusndm 116 26 . . . work_fzrpauvhvnexhintldqhzusndm 117 1 This this DT work_fzrpauvhvnexhintldqhzusndm 117 2 strategy strategy NN work_fzrpauvhvnexhintldqhzusndm 117 3 starts start VBZ work_fzrpauvhvnexhintldqhzusndm 117 4 with with IN work_fzrpauvhvnexhintldqhzusndm 117 5 sample sample NN work_fzrpauvhvnexhintldqhzusndm 117 6 processing processing NN work_fzrpauvhvnexhintldqhzusndm 117 7 , , , work_fzrpauvhvnexhintldqhzusndm 117 8 protocol protocol NN work_fzrpauvhvnexhintldqhzusndm 117 9 testing testing NN work_fzrpauvhvnexhintldqhzusndm 117 10 , , , work_fzrpauvhvnexhintldqhzusndm 117 11 optimization optimization NN work_fzrpauvhvnexhintldqhzusndm 117 12 , , , work_fzrpauvhvnexhintldqhzusndm 117 13 and and CC work_fzrpauvhvnexhintldqhzusndm 117 14 establishment establishment NN work_fzrpauvhvnexhintldqhzusndm 117 15 of of IN work_fzrpauvhvnexhintldqhzusndm 117 16 gold gold JJ work_fzrpauvhvnexhintldqhzusndm 117 17 standard standard JJ work_fzrpauvhvnexhintldqhzusndm 117 18 procedures procedure NNS work_fzrpauvhvnexhintldqhzusndm 117 19 and and CC work_fzrpauvhvnexhintldqhzusndm 117 20 , , , work_fzrpauvhvnexhintldqhzusndm 117 21 importantly importantly RB work_fzrpauvhvnexhintldqhzusndm 117 22 , , , work_fzrpauvhvnexhintldqhzusndm 117 23 technological technological JJ work_fzrpauvhvnexhintldqhzusndm 117 24 and and CC work_fzrpauvhvnexhintldqhzusndm 117 25 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 117 26 controls control NNS work_fzrpauvhvnexhintldqhzusndm 117 27 . . . work_fzrpauvhvnexhintldqhzusndm 118 1 This this DT work_fzrpauvhvnexhintldqhzusndm 118 2 focus focus NN work_fzrpauvhvnexhintldqhzusndm 118 3 on on IN work_fzrpauvhvnexhintldqhzusndm 118 4 quality quality NN work_fzrpauvhvnexhintldqhzusndm 118 5 control control NN work_fzrpauvhvnexhintldqhzusndm 118 6 includes include VBZ work_fzrpauvhvnexhintldqhzusndm 118 7 assurance assurance NN work_fzrpauvhvnexhintldqhzusndm 118 8 of of IN work_fzrpauvhvnexhintldqhzusndm 118 9 lot lot NN work_fzrpauvhvnexhintldqhzusndm 118 10 - - HYPH work_fzrpauvhvnexhintldqhzusndm 118 11 consistent consistent JJ work_fzrpauvhvnexhintldqhzusndm 118 12 performance performance NN work_fzrpauvhvnexhintldqhzusndm 118 13 of of IN work_fzrpauvhvnexhintldqhzusndm 118 14 supplies supply NNS work_fzrpauvhvnexhintldqhzusndm 118 15 and and CC work_fzrpauvhvnexhintldqhzusndm 118 16 reagents reagent NNS work_fzrpauvhvnexhintldqhzusndm 118 17 allowing allow VBG work_fzrpauvhvnexhintldqhzusndm 118 18 minimal minimal JJ work_fzrpauvhvnexhintldqhzusndm 118 19 deviations deviation NNS work_fzrpauvhvnexhintldqhzusndm 118 20 to to TO work_fzrpauvhvnexhintldqhzusndm 118 21 ensure ensure VB work_fzrpauvhvnexhintldqhzusndm 118 22 pristine pristine JJ work_fzrpauvhvnexhintldqhzusndm 118 23 data datum NNS work_fzrpauvhvnexhintldqhzusndm 118 24 collection collection NN work_fzrpauvhvnexhintldqhzusndm 118 25 , , , work_fzrpauvhvnexhintldqhzusndm 118 26 compilation compilation NN work_fzrpauvhvnexhintldqhzusndm 118 27 , , , work_fzrpauvhvnexhintldqhzusndm 118 28 assessment assessment NN work_fzrpauvhvnexhintldqhzusndm 118 29 and and CC work_fzrpauvhvnexhintldqhzusndm 118 30 , , , work_fzrpauvhvnexhintldqhzusndm 118 31 finally finally RB work_fzrpauvhvnexhintldqhzusndm 118 32 , , , work_fzrpauvhvnexhintldqhzusndm 118 33 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 118 34 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 118 35 Figure Figure NNP work_fzrpauvhvnexhintldqhzusndm 118 36 2 2 CD work_fzrpauvhvnexhintldqhzusndm 118 37 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 118 38 . . . work_fzrpauvhvnexhintldqhzusndm 119 1 Small small JJ work_fzrpauvhvnexhintldqhzusndm 119 2 differences difference NNS work_fzrpauvhvnexhintldqhzusndm 119 3 in in IN work_fzrpauvhvnexhintldqhzusndm 119 4 materials material NNS work_fzrpauvhvnexhintldqhzusndm 119 5 and and CC work_fzrpauvhvnexhintldqhzusndm 119 6 supplies supply NNS work_fzrpauvhvnexhintldqhzusndm 119 7 or or CC work_fzrpauvhvnexhintldqhzusndm 119 8 deviations deviation NNS work_fzrpauvhvnexhintldqhzusndm 119 9 in in IN work_fzrpauvhvnexhintldqhzusndm 119 10 procedure procedure NN work_fzrpauvhvnexhintldqhzusndm 119 11 across across IN work_fzrpauvhvnexhintldqhzusndm 119 12 sites site NNS work_fzrpauvhvnexhintldqhzusndm 119 13 can can MD work_fzrpauvhvnexhintldqhzusndm 119 14 entirely entirely RB work_fzrpauvhvnexhintldqhzusndm 119 15 derail derail VB work_fzrpauvhvnexhintldqhzusndm 119 16 a a DT work_fzrpauvhvnexhintldqhzusndm 119 17 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 119 18 study study NN work_fzrpauvhvnexhintldqhzusndm 119 19 . . . work_fzrpauvhvnexhintldqhzusndm 120 1 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 120 2 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 120 3 , , , work_fzrpauvhvnexhintldqhzusndm 120 4 10 10 CD work_fzrpauvhvnexhintldqhzusndm 120 5 5 5 CD work_fzrpauvhvnexhintldqhzusndm 120 6 5.1 5.1 CD work_fzrpauvhvnexhintldqhzusndm 120 7 . . . work_fzrpauvhvnexhintldqhzusndm 121 1 Sample Sample NNP work_fzrpauvhvnexhintldqhzusndm 121 2 Collection Collection NNP work_fzrpauvhvnexhintldqhzusndm 121 3 Multiomic Multiomic NNP work_fzrpauvhvnexhintldqhzusndm 121 4 studies study NNS work_fzrpauvhvnexhintldqhzusndm 121 5 have have VBP work_fzrpauvhvnexhintldqhzusndm 121 6 been be VBN work_fzrpauvhvnexhintldqhzusndm 121 7 successfully successfully RB work_fzrpauvhvnexhintldqhzusndm 121 8 applied apply VBN work_fzrpauvhvnexhintldqhzusndm 121 9 to to IN work_fzrpauvhvnexhintldqhzusndm 121 10 adults adult NNS work_fzrpauvhvnexhintldqhzusndm 121 11 to to TO work_fzrpauvhvnexhintldqhzusndm 121 12 identify identify VB work_fzrpauvhvnexhintldqhzusndm 121 13 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 121 14 correlates correlate NNS work_fzrpauvhvnexhintldqhzusndm 121 15 of of IN work_fzrpauvhvnexhintldqhzusndm 121 16 disease disease NN work_fzrpauvhvnexhintldqhzusndm 121 17 risk risk NN work_fzrpauvhvnexhintldqhzusndm 121 18 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 121 19 26,33 26,33 CD work_fzrpauvhvnexhintldqhzusndm 121 20 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 121 21 . . . work_fzrpauvhvnexhintldqhzusndm 122 1 The the DT work_fzrpauvhvnexhintldqhzusndm 122 2 application application NN work_fzrpauvhvnexhintldqhzusndm 122 3 of of IN work_fzrpauvhvnexhintldqhzusndm 122 4 these these DT work_fzrpauvhvnexhintldqhzusndm 122 5 tools tool NNS work_fzrpauvhvnexhintldqhzusndm 122 6 to to IN work_fzrpauvhvnexhintldqhzusndm 122 7 early early JJ work_fzrpauvhvnexhintldqhzusndm 122 8 infancy infancy NN work_fzrpauvhvnexhintldqhzusndm 122 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 122 10 itself -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 122 11 challenging challenging JJ work_fzrpauvhvnexhintldqhzusndm 122 12 because because IN work_fzrpauvhvnexhintldqhzusndm 122 13 only only RB work_fzrpauvhvnexhintldqhzusndm 122 14 limited limited JJ work_fzrpauvhvnexhintldqhzusndm 122 15 volumes volume NNS work_fzrpauvhvnexhintldqhzusndm 122 16 of of IN work_fzrpauvhvnexhintldqhzusndm 122 17 blood blood NN work_fzrpauvhvnexhintldqhzusndm 122 18 can can MD work_fzrpauvhvnexhintldqhzusndm 122 19 be be VB work_fzrpauvhvnexhintldqhzusndm 122 20 collected collect VBN work_fzrpauvhvnexhintldqhzusndm 122 21 , , , work_fzrpauvhvnexhintldqhzusndm 122 22 and and CC work_fzrpauvhvnexhintldqhzusndm 122 23 collection collection NN work_fzrpauvhvnexhintldqhzusndm 122 24 of of IN work_fzrpauvhvnexhintldqhzusndm 122 25 fasting fast VBG work_fzrpauvhvnexhintldqhzusndm 122 26 blood blood NN work_fzrpauvhvnexhintldqhzusndm 122 27 is be VBZ work_fzrpauvhvnexhintldqhzusndm 122 28 not not RB work_fzrpauvhvnexhintldqhzusndm 122 29 feasible feasible JJ work_fzrpauvhvnexhintldqhzusndm 122 30 . . . work_fzrpauvhvnexhintldqhzusndm 123 1 Despite despite IN work_fzrpauvhvnexhintldqhzusndm 123 2 this this DT work_fzrpauvhvnexhintldqhzusndm 123 3 , , , work_fzrpauvhvnexhintldqhzusndm 123 4 protocols protocol NNS work_fzrpauvhvnexhintldqhzusndm 123 5 for for IN work_fzrpauvhvnexhintldqhzusndm 123 6 small small JJ work_fzrpauvhvnexhintldqhzusndm 123 7 volume volume NN work_fzrpauvhvnexhintldqhzusndm 123 8 collections collection NNS work_fzrpauvhvnexhintldqhzusndm 123 9 yielding yield VBG work_fzrpauvhvnexhintldqhzusndm 123 10 high high JJ work_fzrpauvhvnexhintldqhzusndm 123 11 - - HYPH work_fzrpauvhvnexhintldqhzusndm 123 12 quality quality NN work_fzrpauvhvnexhintldqhzusndm 123 13 data datum NNS work_fzrpauvhvnexhintldqhzusndm 123 14 have have VBP work_fzrpauvhvnexhintldqhzusndm 123 15 been be VBN work_fzrpauvhvnexhintldqhzusndm 123 16 developed develop VBN work_fzrpauvhvnexhintldqhzusndm 123 17 and and CC work_fzrpauvhvnexhintldqhzusndm 123 18 published publish VBN work_fzrpauvhvnexhintldqhzusndm 123 19 . . . work_fzrpauvhvnexhintldqhzusndm 124 1 A a DT work_fzrpauvhvnexhintldqhzusndm 124 2 recent recent JJ work_fzrpauvhvnexhintldqhzusndm 124 3 study study NN work_fzrpauvhvnexhintldqhzusndm 124 4 of of IN work_fzrpauvhvnexhintldqhzusndm 124 5 58 58 CD work_fzrpauvhvnexhintldqhzusndm 124 6 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 124 7 cell cell NN work_fzrpauvhvnexhintldqhzusndm 124 8 populations population NNS work_fzrpauvhvnexhintldqhzusndm 124 9 and and CC work_fzrpauvhvnexhintldqhzusndm 124 10 267 267 CD work_fzrpauvhvnexhintldqhzusndm 124 11 plasma plasma NN work_fzrpauvhvnexhintldqhzusndm 124 12 protein protein NN work_fzrpauvhvnexhintldqhzusndm 124 13 immunoassays immunoassay NNS work_fzrpauvhvnexhintldqhzusndm 124 14 was be VBD work_fzrpauvhvnexhintldqhzusndm 124 15 performed perform VBN work_fzrpauvhvnexhintldqhzusndm 124 16 on on IN work_fzrpauvhvnexhintldqhzusndm 124 17 100 100 CD work_fzrpauvhvnexhintldqhzusndm 124 18 μL μL NNS work_fzrpauvhvnexhintldqhzusndm 124 19 of of IN work_fzrpauvhvnexhintldqhzusndm 124 20 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 124 21 blood blood NN work_fzrpauvhvnexhintldqhzusndm 124 22 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 124 23 8 8 CD work_fzrpauvhvnexhintldqhzusndm 124 24 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 124 25 . . . work_fzrpauvhvnexhintldqhzusndm 125 1 Whole whole JJ work_fzrpauvhvnexhintldqhzusndm 125 2 blood blood NN work_fzrpauvhvnexhintldqhzusndm 125 3 represents represent VBZ work_fzrpauvhvnexhintldqhzusndm 125 4 a a DT work_fzrpauvhvnexhintldqhzusndm 125 5 convenient convenient JJ work_fzrpauvhvnexhintldqhzusndm 125 6 and and CC work_fzrpauvhvnexhintldqhzusndm 125 7 attractive attractive JJ work_fzrpauvhvnexhintldqhzusndm 125 8 tissue tissue NN work_fzrpauvhvnexhintldqhzusndm 125 9 for for IN work_fzrpauvhvnexhintldqhzusndm 125 10 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 125 11 studies study NNS work_fzrpauvhvnexhintldqhzusndm 125 12 that that WDT work_fzrpauvhvnexhintldqhzusndm 125 13 is be VBZ work_fzrpauvhvnexhintldqhzusndm 125 14 amenable amenable JJ work_fzrpauvhvnexhintldqhzusndm 125 15 to to TO work_fzrpauvhvnexhintldqhzusndm 125 16 fractionation fractionation VB work_fzrpauvhvnexhintldqhzusndm 125 17 into into IN work_fzrpauvhvnexhintldqhzusndm 125 18 different different JJ work_fzrpauvhvnexhintldqhzusndm 125 19 aliquots aliquot NNS work_fzrpauvhvnexhintldqhzusndm 125 20 for for IN work_fzrpauvhvnexhintldqhzusndm 125 21 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 125 22 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 125 23 platforms platform NNS work_fzrpauvhvnexhintldqhzusndm 125 24 that that WDT work_fzrpauvhvnexhintldqhzusndm 125 25 can can MD work_fzrpauvhvnexhintldqhzusndm 125 26 be be VB work_fzrpauvhvnexhintldqhzusndm 125 27 integrated integrate VBN work_fzrpauvhvnexhintldqhzusndm 125 28 following follow VBG work_fzrpauvhvnexhintldqhzusndm 125 29 data data NN work_fzrpauvhvnexhintldqhzusndm 125 30 generation generation NN work_fzrpauvhvnexhintldqhzusndm 125 31 . . . work_fzrpauvhvnexhintldqhzusndm 126 1 The the DT work_fzrpauvhvnexhintldqhzusndm 126 2 caveat caveat NN work_fzrpauvhvnexhintldqhzusndm 126 3 of of IN work_fzrpauvhvnexhintldqhzusndm 126 4 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 126 5 blood blood NN work_fzrpauvhvnexhintldqhzusndm 126 6 is be VBZ work_fzrpauvhvnexhintldqhzusndm 126 7 that that IN work_fzrpauvhvnexhintldqhzusndm 126 8 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 126 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 126 10 a a DT work_fzrpauvhvnexhintldqhzusndm 126 11 complex complex JJ work_fzrpauvhvnexhintldqhzusndm 126 12 tissue tissue NN work_fzrpauvhvnexhintldqhzusndm 126 13 , , , work_fzrpauvhvnexhintldqhzusndm 126 14 and and CC work_fzrpauvhvnexhintldqhzusndm 126 15 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 126 16 profiles profile NNS work_fzrpauvhvnexhintldqhzusndm 126 17 therefore therefore RB work_fzrpauvhvnexhintldqhzusndm 126 18 represent represent VBP work_fzrpauvhvnexhintldqhzusndm 126 19 an an DT work_fzrpauvhvnexhintldqhzusndm 126 20 average average JJ work_fzrpauvhvnexhintldqhzusndm 126 21 profile profile NN work_fzrpauvhvnexhintldqhzusndm 126 22 across across IN work_fzrpauvhvnexhintldqhzusndm 126 23 all all DT work_fzrpauvhvnexhintldqhzusndm 126 24 cells cell NNS work_fzrpauvhvnexhintldqhzusndm 126 25 in in IN work_fzrpauvhvnexhintldqhzusndm 126 26 the the DT work_fzrpauvhvnexhintldqhzusndm 126 27 blood blood NN work_fzrpauvhvnexhintldqhzusndm 126 28 sample sample NN work_fzrpauvhvnexhintldqhzusndm 126 29 , , , work_fzrpauvhvnexhintldqhzusndm 126 30 which which WDT work_fzrpauvhvnexhintldqhzusndm 126 31 can can MD work_fzrpauvhvnexhintldqhzusndm 126 32 limit limit VB work_fzrpauvhvnexhintldqhzusndm 126 33 analyses analysis NNS work_fzrpauvhvnexhintldqhzusndm 126 34 of of IN work_fzrpauvhvnexhintldqhzusndm 126 35 cell cell NN work_fzrpauvhvnexhintldqhzusndm 126 36 specific specific JJ work_fzrpauvhvnexhintldqhzusndm 126 37 effects effect NNS work_fzrpauvhvnexhintldqhzusndm 126 38 . . . work_fzrpauvhvnexhintldqhzusndm 127 1 Despite despite IN work_fzrpauvhvnexhintldqhzusndm 127 2 this this DT work_fzrpauvhvnexhintldqhzusndm 127 3 , , , work_fzrpauvhvnexhintldqhzusndm 127 4 whole whole JJ work_fzrpauvhvnexhintldqhzusndm 127 5 blood blood NN work_fzrpauvhvnexhintldqhzusndm 127 6 is be VBZ work_fzrpauvhvnexhintldqhzusndm 127 7 likely likely JJ work_fzrpauvhvnexhintldqhzusndm 127 8 to to TO work_fzrpauvhvnexhintldqhzusndm 127 9 be be VB work_fzrpauvhvnexhintldqhzusndm 127 10 the the DT work_fzrpauvhvnexhintldqhzusndm 127 11 tissue tissue NN work_fzrpauvhvnexhintldqhzusndm 127 12 of of IN work_fzrpauvhvnexhintldqhzusndm 127 13 choice choice NN work_fzrpauvhvnexhintldqhzusndm 127 14 for for IN work_fzrpauvhvnexhintldqhzusndm 127 15 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 127 16 studies study NNS work_fzrpauvhvnexhintldqhzusndm 127 17 with with IN work_fzrpauvhvnexhintldqhzusndm 127 18 protocols protocol NNS work_fzrpauvhvnexhintldqhzusndm 127 19 in in IN work_fzrpauvhvnexhintldqhzusndm 127 20 development development NN work_fzrpauvhvnexhintldqhzusndm 127 21 that that WDT work_fzrpauvhvnexhintldqhzusndm 127 22 allow allow VBP work_fzrpauvhvnexhintldqhzusndm 127 23 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 127 24 profiling profiling NN work_fzrpauvhvnexhintldqhzusndm 127 25 , , , work_fzrpauvhvnexhintldqhzusndm 127 26 genetics genetic NNS work_fzrpauvhvnexhintldqhzusndm 127 27 , , , work_fzrpauvhvnexhintldqhzusndm 127 28 transcriptomics transcriptomic NNS work_fzrpauvhvnexhintldqhzusndm 127 29 , , , work_fzrpauvhvnexhintldqhzusndm 127 30 epigenetics epigenetic NNS work_fzrpauvhvnexhintldqhzusndm 127 31 , , , work_fzrpauvhvnexhintldqhzusndm 127 32 metabolomics metabolomic NNS work_fzrpauvhvnexhintldqhzusndm 127 33 , , , work_fzrpauvhvnexhintldqhzusndm 127 34 and and CC work_fzrpauvhvnexhintldqhzusndm 127 35 exposome exposome JJ work_fzrpauvhvnexhintldqhzusndm 127 36 profiling profiling NN work_fzrpauvhvnexhintldqhzusndm 127 37 from from IN work_fzrpauvhvnexhintldqhzusndm 127 38 less less JJR work_fzrpauvhvnexhintldqhzusndm 127 39 than than IN work_fzrpauvhvnexhintldqhzusndm 127 40 5 5 CD work_fzrpauvhvnexhintldqhzusndm 127 41 mL ml NN work_fzrpauvhvnexhintldqhzusndm 127 42 of of IN work_fzrpauvhvnexhintldqhzusndm 127 43 blood blood NN work_fzrpauvhvnexhintldqhzusndm 127 44 . . . work_fzrpauvhvnexhintldqhzusndm 128 1 In in IN work_fzrpauvhvnexhintldqhzusndm 128 2 order order NN work_fzrpauvhvnexhintldqhzusndm 128 3 to to TO work_fzrpauvhvnexhintldqhzusndm 128 4 ensure ensure VB work_fzrpauvhvnexhintldqhzusndm 128 5 data datum NNS work_fzrpauvhvnexhintldqhzusndm 128 6 veracity veracity NN work_fzrpauvhvnexhintldqhzusndm 128 7 , , , work_fzrpauvhvnexhintldqhzusndm 128 8 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 128 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 128 10 crucial crucial JJ work_fzrpauvhvnexhintldqhzusndm 128 11 to to TO work_fzrpauvhvnexhintldqhzusndm 128 12 stringently stringently RB work_fzrpauvhvnexhintldqhzusndm 128 13 standardize standardize VB work_fzrpauvhvnexhintldqhzusndm 128 14 the the DT work_fzrpauvhvnexhintldqhzusndm 128 15 processes process NNS work_fzrpauvhvnexhintldqhzusndm 128 16 of of IN work_fzrpauvhvnexhintldqhzusndm 128 17 sample sample NN work_fzrpauvhvnexhintldqhzusndm 128 18 preparation preparation NN work_fzrpauvhvnexhintldqhzusndm 128 19 even even RB work_fzrpauvhvnexhintldqhzusndm 128 20 before before IN work_fzrpauvhvnexhintldqhzusndm 128 21 considering consider VBG work_fzrpauvhvnexhintldqhzusndm 128 22 the the DT work_fzrpauvhvnexhintldqhzusndm 128 23 different different JJ work_fzrpauvhvnexhintldqhzusndm 128 24 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 128 25 assays assay NNS work_fzrpauvhvnexhintldqhzusndm 128 26 . . . work_fzrpauvhvnexhintldqhzusndm 129 1 This this DT work_fzrpauvhvnexhintldqhzusndm 129 2 strategy strategy NN work_fzrpauvhvnexhintldqhzusndm 129 3 starts start VBZ work_fzrpauvhvnexhintldqhzusndm 129 4 with with IN work_fzrpauvhvnexhintldqhzusndm 129 5 sample sample NN work_fzrpauvhvnexhintldqhzusndm 129 6 processing processing NN work_fzrpauvhvnexhintldqhzusndm 129 7 , , , work_fzrpauvhvnexhintldqhzusndm 129 8 protocol protocol NN work_fzrpauvhvnexhintldqhzusndm 129 9 testing testing NN work_fzrpauvhvnexhintldqhzusndm 129 10 , , , work_fzrpauvhvnexhintldqhzusndm 129 11 optimization optimization NN work_fzrpauvhvnexhintldqhzusndm 129 12 , , , work_fzrpauvhvnexhintldqhzusndm 129 13 and and CC work_fzrpauvhvnexhintldqhzusndm 129 14 establishment establishment NN work_fzrpauvhvnexhintldqhzusndm 129 15 of of IN work_fzrpauvhvnexhintldqhzusndm 129 16 gold gold JJ work_fzrpauvhvnexhintldqhzusndm 129 17 standard standard JJ work_fzrpauvhvnexhintldqhzusndm 129 18 procedures procedure NNS work_fzrpauvhvnexhintldqhzusndm 129 19 and and CC work_fzrpauvhvnexhintldqhzusndm 129 20 , , , work_fzrpauvhvnexhintldqhzusndm 129 21 importantly importantly RB work_fzrpauvhvnexhintldqhzusndm 129 22 , , , work_fzrpauvhvnexhintldqhzusndm 129 23 technological technological JJ work_fzrpauvhvnexhintldqhzusndm 129 24 and and CC work_fzrpauvhvnexhintldqhzusndm 129 25 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 129 26 controls control NNS work_fzrpauvhvnexhintldqhzusndm 129 27 . . . work_fzrpauvhvnexhintldqhzusndm 130 1 This this DT work_fzrpauvhvnexhintldqhzusndm 130 2 focus focus NN work_fzrpauvhvnexhintldqhzusndm 130 3 on on IN work_fzrpauvhvnexhintldqhzusndm 130 4 quality quality NN work_fzrpauvhvnexhintldqhzusndm 130 5 control control NN work_fzrpauvhvnexhintldqhzusndm 130 6 includes include VBZ work_fzrpauvhvnexhintldqhzusndm 130 7 assurance assurance NN work_fzrpauvhvnexhintldqhzusndm 130 8 of of IN work_fzrpauvhvnexhintldqhzusndm 130 9 lot lot NN work_fzrpauvhvnexhintldqhzusndm 130 10 - - HYPH work_fzrpauvhvnexhintldqhzusndm 130 11 consistent consistent JJ work_fzrpauvhvnexhintldqhzusndm 130 12 performance performance NN work_fzrpauvhvnexhintldqhzusndm 130 13 of of IN work_fzrpauvhvnexhintldqhzusndm 130 14 supplies supply NNS work_fzrpauvhvnexhintldqhzusndm 130 15 and and CC work_fzrpauvhvnexhintldqhzusndm 130 16 reagents reagent NNS work_fzrpauvhvnexhintldqhzusndm 130 17 allowing allow VBG work_fzrpauvhvnexhintldqhzusndm 130 18 minimal minimal JJ work_fzrpauvhvnexhintldqhzusndm 130 19 deviations deviation NNS work_fzrpauvhvnexhintldqhzusndm 130 20 to to TO work_fzrpauvhvnexhintldqhzusndm 130 21 ensure ensure VB work_fzrpauvhvnexhintldqhzusndm 130 22 pristine pristine JJ work_fzrpauvhvnexhintldqhzusndm 130 23 data datum NNS work_fzrpauvhvnexhintldqhzusndm 130 24 collection collection NN work_fzrpauvhvnexhintldqhzusndm 130 25 , , , work_fzrpauvhvnexhintldqhzusndm 130 26 compilation compilation NN work_fzrpauvhvnexhintldqhzusndm 130 27 , , , work_fzrpauvhvnexhintldqhzusndm 130 28 assessment assessment NN work_fzrpauvhvnexhintldqhzusndm 130 29 and and CC work_fzrpauvhvnexhintldqhzusndm 130 30 , , , work_fzrpauvhvnexhintldqhzusndm 130 31 finally finally RB work_fzrpauvhvnexhintldqhzusndm 130 32 , , , work_fzrpauvhvnexhintldqhzusndm 130 33 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 130 34 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 130 35 figure figure NNP work_fzrpauvhvnexhintldqhzusndm 130 36 2 2 CD work_fzrpauvhvnexhintldqhzusndm 130 37 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 130 38 . . . work_fzrpauvhvnexhintldqhzusndm 131 1 Small small JJ work_fzrpauvhvnexhintldqhzusndm 131 2 differences difference NNS work_fzrpauvhvnexhintldqhzusndm 131 3 in in IN work_fzrpauvhvnexhintldqhzusndm 131 4 materials material NNS work_fzrpauvhvnexhintldqhzusndm 131 5 and and CC work_fzrpauvhvnexhintldqhzusndm 131 6 supplies supply NNS work_fzrpauvhvnexhintldqhzusndm 131 7 or or CC work_fzrpauvhvnexhintldqhzusndm 131 8 deviations deviation NNS work_fzrpauvhvnexhintldqhzusndm 131 9 in in IN work_fzrpauvhvnexhintldqhzusndm 131 10 procedure procedure NN work_fzrpauvhvnexhintldqhzusndm 131 11 across across IN work_fzrpauvhvnexhintldqhzusndm 131 12 sites site NNS work_fzrpauvhvnexhintldqhzusndm 131 13 can can MD work_fzrpauvhvnexhintldqhzusndm 131 14 entirely entirely RB work_fzrpauvhvnexhintldqhzusndm 131 15 derail derail VB work_fzrpauvhvnexhintldqhzusndm 131 16 a a DT work_fzrpauvhvnexhintldqhzusndm 131 17 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 131 18 study study NN work_fzrpauvhvnexhintldqhzusndm 131 19 . . . work_fzrpauvhvnexhintldqhzusndm 132 1 Figure figure NN work_fzrpauvhvnexhintldqhzusndm 132 2 2 2 CD work_fzrpauvhvnexhintldqhzusndm 132 3 . . . work_fzrpauvhvnexhintldqhzusndm 133 1 Production production NN work_fzrpauvhvnexhintldqhzusndm 133 2 workflow workflow NN work_fzrpauvhvnexhintldqhzusndm 133 3 for for IN work_fzrpauvhvnexhintldqhzusndm 133 4 sample sample NN work_fzrpauvhvnexhintldqhzusndm 133 5 collection collection NN work_fzrpauvhvnexhintldqhzusndm 133 6 in in IN work_fzrpauvhvnexhintldqhzusndm 133 7 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 133 8 studies study NNS work_fzrpauvhvnexhintldqhzusndm 133 9 . . . work_fzrpauvhvnexhintldqhzusndm 134 1 Standardization standardization NN work_fzrpauvhvnexhintldqhzusndm 134 2 of of IN work_fzrpauvhvnexhintldqhzusndm 134 3 sample sample NN work_fzrpauvhvnexhintldqhzusndm 134 4 collection collection NN work_fzrpauvhvnexhintldqhzusndm 134 5 can can MD work_fzrpauvhvnexhintldqhzusndm 134 6 be be VB work_fzrpauvhvnexhintldqhzusndm 134 7 systematically systematically RB work_fzrpauvhvnexhintldqhzusndm 134 8 undertaken undertake VBN work_fzrpauvhvnexhintldqhzusndm 134 9 using use VBG work_fzrpauvhvnexhintldqhzusndm 134 10 a a DT work_fzrpauvhvnexhintldqhzusndm 134 11 production production NN work_fzrpauvhvnexhintldqhzusndm 134 12 workflow workflow NN work_fzrpauvhvnexhintldqhzusndm 134 13 . . . work_fzrpauvhvnexhintldqhzusndm 135 1 For for IN work_fzrpauvhvnexhintldqhzusndm 135 2 each each DT work_fzrpauvhvnexhintldqhzusndm 135 3 sample sample NN work_fzrpauvhvnexhintldqhzusndm 135 4 type type NN work_fzrpauvhvnexhintldqhzusndm 135 5 , , , work_fzrpauvhvnexhintldqhzusndm 135 6 protocols protocol NNS work_fzrpauvhvnexhintldqhzusndm 135 7 are be VBP work_fzrpauvhvnexhintldqhzusndm 135 8 developed develop VBN work_fzrpauvhvnexhintldqhzusndm 135 9 and and CC work_fzrpauvhvnexhintldqhzusndm 135 10 tested test VBN work_fzrpauvhvnexhintldqhzusndm 135 11 according accord VBG work_fzrpauvhvnexhintldqhzusndm 135 12 to to IN work_fzrpauvhvnexhintldqhzusndm 135 13 pre pre JJ work_fzrpauvhvnexhintldqhzusndm 135 14 - - JJ work_fzrpauvhvnexhintldqhzusndm 135 15 determined determine VBN work_fzrpauvhvnexhintldqhzusndm 135 16 key key JJ work_fzrpauvhvnexhintldqhzusndm 135 17 performance performance NN work_fzrpauvhvnexhintldqhzusndm 135 18 indicators indicator NNS work_fzrpauvhvnexhintldqhzusndm 135 19 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 135 20 KPIs KPIs NNP work_fzrpauvhvnexhintldqhzusndm 135 21 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 135 22 before before IN work_fzrpauvhvnexhintldqhzusndm 135 23 moving move VBG work_fzrpauvhvnexhintldqhzusndm 135 24 into into IN work_fzrpauvhvnexhintldqhzusndm 135 25 production production NN work_fzrpauvhvnexhintldqhzusndm 135 26 . . . work_fzrpauvhvnexhintldqhzusndm 136 1 KPIs kpi NNS work_fzrpauvhvnexhintldqhzusndm 136 2 are be VBP work_fzrpauvhvnexhintldqhzusndm 136 3 determined determine VBN work_fzrpauvhvnexhintldqhzusndm 136 4 by by IN work_fzrpauvhvnexhintldqhzusndm 136 5 investigators investigator NNS work_fzrpauvhvnexhintldqhzusndm 136 6 but but CC work_fzrpauvhvnexhintldqhzusndm 136 7 could could MD work_fzrpauvhvnexhintldqhzusndm 136 8 include include VB work_fzrpauvhvnexhintldqhzusndm 136 9 standard standard JJ work_fzrpauvhvnexhintldqhzusndm 136 10 quality quality NN work_fzrpauvhvnexhintldqhzusndm 136 11 control control NN work_fzrpauvhvnexhintldqhzusndm 136 12 metrics metric NNS work_fzrpauvhvnexhintldqhzusndm 136 13 published publish VBN work_fzrpauvhvnexhintldqhzusndm 136 14 in in IN work_fzrpauvhvnexhintldqhzusndm 136 15 the the DT work_fzrpauvhvnexhintldqhzusndm 136 16 medical medical JJ work_fzrpauvhvnexhintldqhzusndm 136 17 literature literature NN work_fzrpauvhvnexhintldqhzusndm 136 18 . . . work_fzrpauvhvnexhintldqhzusndm 137 1 The the DT work_fzrpauvhvnexhintldqhzusndm 137 2 process process NN work_fzrpauvhvnexhintldqhzusndm 137 3 is be VBZ work_fzrpauvhvnexhintldqhzusndm 137 4 iterative iterative JJ work_fzrpauvhvnexhintldqhzusndm 137 5 , , , work_fzrpauvhvnexhintldqhzusndm 137 6 so so RB work_fzrpauvhvnexhintldqhzusndm 137 7 the the DT work_fzrpauvhvnexhintldqhzusndm 137 8 methodology methodology NN work_fzrpauvhvnexhintldqhzusndm 137 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 137 10 optimized optimize VBN work_fzrpauvhvnexhintldqhzusndm 137 11 if if IN work_fzrpauvhvnexhintldqhzusndm 137 12 KPIs kpi NNS work_fzrpauvhvnexhintldqhzusndm 137 13 are be VBP work_fzrpauvhvnexhintldqhzusndm 137 14 not not RB work_fzrpauvhvnexhintldqhzusndm 137 15 achieved achieve VBN work_fzrpauvhvnexhintldqhzusndm 137 16 , , , work_fzrpauvhvnexhintldqhzusndm 137 17 and and CC work_fzrpauvhvnexhintldqhzusndm 137 18 proceed proceed VB work_fzrpauvhvnexhintldqhzusndm 137 19 through through IN work_fzrpauvhvnexhintldqhzusndm 137 20 re re NN work_fzrpauvhvnexhintldqhzusndm 137 21 - - NN work_fzrpauvhvnexhintldqhzusndm 137 22 testing testing NN work_fzrpauvhvnexhintldqhzusndm 137 23 until until IN work_fzrpauvhvnexhintldqhzusndm 137 24 targets target NNS work_fzrpauvhvnexhintldqhzusndm 137 25 are be VBP work_fzrpauvhvnexhintldqhzusndm 137 26 met meet VBN work_fzrpauvhvnexhintldqhzusndm 137 27 . . . work_fzrpauvhvnexhintldqhzusndm 138 1 5.2 5.2 CD work_fzrpauvhvnexhintldqhzusndm 138 2 . . . work_fzrpauvhvnexhintldqhzusndm 139 1 Data Data NNPS work_fzrpauvhvnexhintldqhzusndm 139 2 Collection Collection NNP work_fzrpauvhvnexhintldqhzusndm 139 3 Researchers researcher NNS work_fzrpauvhvnexhintldqhzusndm 139 4 should should MD work_fzrpauvhvnexhintldqhzusndm 139 5 identify identify VB work_fzrpauvhvnexhintldqhzusndm 139 6 data datum NNS work_fzrpauvhvnexhintldqhzusndm 139 7 which which WDT work_fzrpauvhvnexhintldqhzusndm 139 8 may may MD work_fzrpauvhvnexhintldqhzusndm 139 9 be be VB work_fzrpauvhvnexhintldqhzusndm 139 10 important important JJ work_fzrpauvhvnexhintldqhzusndm 139 11 to to IN work_fzrpauvhvnexhintldqhzusndm 139 12 downstream downstream JJ work_fzrpauvhvnexhintldqhzusndm 139 13 quality quality NN work_fzrpauvhvnexhintldqhzusndm 139 14 control control NN work_fzrpauvhvnexhintldqhzusndm 139 15 . . . work_fzrpauvhvnexhintldqhzusndm 140 1 For for IN work_fzrpauvhvnexhintldqhzusndm 140 2 instance instance NN work_fzrpauvhvnexhintldqhzusndm 140 3 , , , work_fzrpauvhvnexhintldqhzusndm 140 4 tracking track VBG work_fzrpauvhvnexhintldqhzusndm 140 5 the the DT work_fzrpauvhvnexhintldqhzusndm 140 6 information information NN work_fzrpauvhvnexhintldqhzusndm 140 7 about about IN work_fzrpauvhvnexhintldqhzusndm 140 8 storage storage NN work_fzrpauvhvnexhintldqhzusndm 140 9 conditions condition NNS work_fzrpauvhvnexhintldqhzusndm 140 10 of of IN work_fzrpauvhvnexhintldqhzusndm 140 11 a a DT work_fzrpauvhvnexhintldqhzusndm 140 12 sample sample NN work_fzrpauvhvnexhintldqhzusndm 140 13 , , , work_fzrpauvhvnexhintldqhzusndm 140 14 or or CC work_fzrpauvhvnexhintldqhzusndm 140 15 the the DT work_fzrpauvhvnexhintldqhzusndm 140 16 time time NN work_fzrpauvhvnexhintldqhzusndm 140 17 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 140 18 takes take VBZ work_fzrpauvhvnexhintldqhzusndm 140 19 for for IN work_fzrpauvhvnexhintldqhzusndm 140 20 the the DT work_fzrpauvhvnexhintldqhzusndm 140 21 sample sample NN work_fzrpauvhvnexhintldqhzusndm 140 22 collection collection NN work_fzrpauvhvnexhintldqhzusndm 140 23 , , , work_fzrpauvhvnexhintldqhzusndm 140 24 not not RB work_fzrpauvhvnexhintldqhzusndm 140 25 only only RB work_fzrpauvhvnexhintldqhzusndm 140 26 informs inform VBZ work_fzrpauvhvnexhintldqhzusndm 140 27 about about IN work_fzrpauvhvnexhintldqhzusndm 140 28 its -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 140 29 quality quality NN work_fzrpauvhvnexhintldqhzusndm 140 30 but but CC work_fzrpauvhvnexhintldqhzusndm 140 31 also also RB work_fzrpauvhvnexhintldqhzusndm 140 32 can can MD work_fzrpauvhvnexhintldqhzusndm 140 33 help help VB work_fzrpauvhvnexhintldqhzusndm 140 34 discriminate discriminate VB work_fzrpauvhvnexhintldqhzusndm 140 35 outliers outlier NNS work_fzrpauvhvnexhintldqhzusndm 140 36 from from IN work_fzrpauvhvnexhintldqhzusndm 140 37 subjects subject NNS work_fzrpauvhvnexhintldqhzusndm 140 38 showing show VBG work_fzrpauvhvnexhintldqhzusndm 140 39 meaningful meaningful JJ work_fzrpauvhvnexhintldqhzusndm 140 40 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 140 41 differences difference NNS work_fzrpauvhvnexhintldqhzusndm 140 42 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 140 43 34 34 CD work_fzrpauvhvnexhintldqhzusndm 140 44 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 140 45 . . . work_fzrpauvhvnexhintldqhzusndm 141 1 It -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 141 2 is be VBZ work_fzrpauvhvnexhintldqhzusndm 141 3 also also RB work_fzrpauvhvnexhintldqhzusndm 141 4 very very RB work_fzrpauvhvnexhintldqhzusndm 141 5 important important JJ work_fzrpauvhvnexhintldqhzusndm 141 6 to to TO work_fzrpauvhvnexhintldqhzusndm 141 7 record record VB work_fzrpauvhvnexhintldqhzusndm 141 8 the the DT work_fzrpauvhvnexhintldqhzusndm 141 9 right right JJ work_fzrpauvhvnexhintldqhzusndm 141 10 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 141 11 about about IN work_fzrpauvhvnexhintldqhzusndm 141 12 the the DT work_fzrpauvhvnexhintldqhzusndm 141 13 study study NN work_fzrpauvhvnexhintldqhzusndm 141 14 subjects subject NNS work_fzrpauvhvnexhintldqhzusndm 141 15 as as IN work_fzrpauvhvnexhintldqhzusndm 141 16 this this DT work_fzrpauvhvnexhintldqhzusndm 141 17 will will MD work_fzrpauvhvnexhintldqhzusndm 141 18 be be VB work_fzrpauvhvnexhintldqhzusndm 141 19 one one CD work_fzrpauvhvnexhintldqhzusndm 141 20 of of IN work_fzrpauvhvnexhintldqhzusndm 141 21 the the DT work_fzrpauvhvnexhintldqhzusndm 141 22 major major JJ work_fzrpauvhvnexhintldqhzusndm 141 23 components component NNS work_fzrpauvhvnexhintldqhzusndm 141 24 of of IN work_fzrpauvhvnexhintldqhzusndm 141 25 the the DT work_fzrpauvhvnexhintldqhzusndm 141 26 multiomic multiomic NNP work_fzrpauvhvnexhintldqhzusndm 141 27 data data NNP work_fzrpauvhvnexhintldqhzusndm 141 28 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 141 29 . . . work_fzrpauvhvnexhintldqhzusndm 142 1 Correlations correlation NNS work_fzrpauvhvnexhintldqhzusndm 142 2 between between IN work_fzrpauvhvnexhintldqhzusndm 142 3 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 142 4 data datum NNS work_fzrpauvhvnexhintldqhzusndm 142 5 and and CC work_fzrpauvhvnexhintldqhzusndm 142 6 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 142 7 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 142 8 often often RB work_fzrpauvhvnexhintldqhzusndm 142 9 make make VBP work_fzrpauvhvnexhintldqhzusndm 142 10 up up RP work_fzrpauvhvnexhintldqhzusndm 142 11 a a DT work_fzrpauvhvnexhintldqhzusndm 142 12 major major JJ work_fzrpauvhvnexhintldqhzusndm 142 13 portion portion NN work_fzrpauvhvnexhintldqhzusndm 142 14 of of IN work_fzrpauvhvnexhintldqhzusndm 142 15 the the DT work_fzrpauvhvnexhintldqhzusndm 142 16 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 142 17 , , , work_fzrpauvhvnexhintldqhzusndm 142 18 which which WDT work_fzrpauvhvnexhintldqhzusndm 142 19 is be VBZ work_fzrpauvhvnexhintldqhzusndm 142 20 why why WRB work_fzrpauvhvnexhintldqhzusndm 142 21 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 142 22 is be VBZ work_fzrpauvhvnexhintldqhzusndm 142 23 extremely extremely RB work_fzrpauvhvnexhintldqhzusndm 142 24 important important JJ work_fzrpauvhvnexhintldqhzusndm 142 25 to to TO work_fzrpauvhvnexhintldqhzusndm 142 26 put put VB work_fzrpauvhvnexhintldqhzusndm 142 27 careful careful JJ work_fzrpauvhvnexhintldqhzusndm 142 28 consideration consideration NN work_fzrpauvhvnexhintldqhzusndm 142 29 into into IN work_fzrpauvhvnexhintldqhzusndm 142 30 what what WDT work_fzrpauvhvnexhintldqhzusndm 142 31 information information NN work_fzrpauvhvnexhintldqhzusndm 142 32 will will MD work_fzrpauvhvnexhintldqhzusndm 142 33 be be VB work_fzrpauvhvnexhintldqhzusndm 142 34 collected collect VBN work_fzrpauvhvnexhintldqhzusndm 142 35 prior prior RB work_fzrpauvhvnexhintldqhzusndm 142 36 to to IN work_fzrpauvhvnexhintldqhzusndm 142 37 enrollment enrollment NN work_fzrpauvhvnexhintldqhzusndm 142 38 of of IN work_fzrpauvhvnexhintldqhzusndm 142 39 the the DT work_fzrpauvhvnexhintldqhzusndm 142 40 participants participant NNS work_fzrpauvhvnexhintldqhzusndm 142 41 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 142 42 35 35 CD work_fzrpauvhvnexhintldqhzusndm 142 43 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 142 44 . . . work_fzrpauvhvnexhintldqhzusndm 143 1 These these DT work_fzrpauvhvnexhintldqhzusndm 143 2 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 143 3 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 143 4 are be VBP work_fzrpauvhvnexhintldqhzusndm 143 5 study study NN work_fzrpauvhvnexhintldqhzusndm 143 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 143 7 specific specific JJ work_fzrpauvhvnexhintldqhzusndm 143 8 and and CC work_fzrpauvhvnexhintldqhzusndm 143 9 depend depend VB work_fzrpauvhvnexhintldqhzusndm 143 10 on on IN work_fzrpauvhvnexhintldqhzusndm 143 11 the the DT work_fzrpauvhvnexhintldqhzusndm 143 12 nature nature NN work_fzrpauvhvnexhintldqhzusndm 143 13 of of IN work_fzrpauvhvnexhintldqhzusndm 143 14 the the DT work_fzrpauvhvnexhintldqhzusndm 143 15 disease disease NN work_fzrpauvhvnexhintldqhzusndm 143 16 or or CC work_fzrpauvhvnexhintldqhzusndm 143 17 the the DT work_fzrpauvhvnexhintldqhzusndm 143 18 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 143 19 question question NN work_fzrpauvhvnexhintldqhzusndm 143 20 asked ask VBD work_fzrpauvhvnexhintldqhzusndm 143 21 . . . work_fzrpauvhvnexhintldqhzusndm 144 1 The the DT work_fzrpauvhvnexhintldqhzusndm 144 2 Figure figure NN work_fzrpauvhvnexhintldqhzusndm 144 3 2 2 CD work_fzrpauvhvnexhintldqhzusndm 144 4 . . . work_fzrpauvhvnexhintldqhzusndm 145 1 Production production NN work_fzrpauvhvnexhintldqhzusndm 145 2 workflow workflow NN work_fzrpauvhvnexhintldqhzusndm 145 3 for for IN work_fzrpauvhvnexhintldqhzusndm 145 4 sample sample NN work_fzrpauvhvnexhintldqhzusndm 145 5 collection collection NN work_fzrpauvhvnexhintldqhzusndm 145 6 in in IN work_fzrpauvhvnexhintldqhzusndm 145 7 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 145 8 studies study NNS work_fzrpauvhvnexhintldqhzusndm 145 9 . . . work_fzrpauvhvnexhintldqhzusndm 146 1 Standardization standardization NN work_fzrpauvhvnexhintldqhzusndm 146 2 of of IN work_fzrpauvhvnexhintldqhzusndm 146 3 sample sample NN work_fzrpauvhvnexhintldqhzusndm 146 4 collection collection NN work_fzrpauvhvnexhintldqhzusndm 146 5 can can MD work_fzrpauvhvnexhintldqhzusndm 146 6 be be VB work_fzrpauvhvnexhintldqhzusndm 146 7 systematically systematically RB work_fzrpauvhvnexhintldqhzusndm 146 8 undertaken undertake VBN work_fzrpauvhvnexhintldqhzusndm 146 9 using use VBG work_fzrpauvhvnexhintldqhzusndm 146 10 a a DT work_fzrpauvhvnexhintldqhzusndm 146 11 production production NN work_fzrpauvhvnexhintldqhzusndm 146 12 workflow workflow NN work_fzrpauvhvnexhintldqhzusndm 146 13 . . . work_fzrpauvhvnexhintldqhzusndm 147 1 For for IN work_fzrpauvhvnexhintldqhzusndm 147 2 each each DT work_fzrpauvhvnexhintldqhzusndm 147 3 sample sample NN work_fzrpauvhvnexhintldqhzusndm 147 4 type type NN work_fzrpauvhvnexhintldqhzusndm 147 5 , , , work_fzrpauvhvnexhintldqhzusndm 147 6 protocols protocol NNS work_fzrpauvhvnexhintldqhzusndm 147 7 are be VBP work_fzrpauvhvnexhintldqhzusndm 147 8 developed develop VBN work_fzrpauvhvnexhintldqhzusndm 147 9 and and CC work_fzrpauvhvnexhintldqhzusndm 147 10 tested test VBN work_fzrpauvhvnexhintldqhzusndm 147 11 according accord VBG work_fzrpauvhvnexhintldqhzusndm 147 12 to to IN work_fzrpauvhvnexhintldqhzusndm 147 13 pre pre JJ work_fzrpauvhvnexhintldqhzusndm 147 14 - - JJ work_fzrpauvhvnexhintldqhzusndm 147 15 determined determine VBN work_fzrpauvhvnexhintldqhzusndm 147 16 key key JJ work_fzrpauvhvnexhintldqhzusndm 147 17 performance performance NN work_fzrpauvhvnexhintldqhzusndm 147 18 indicators indicator NNS work_fzrpauvhvnexhintldqhzusndm 147 19 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 147 20 KPIs KPIs NNP work_fzrpauvhvnexhintldqhzusndm 147 21 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 147 22 before before IN work_fzrpauvhvnexhintldqhzusndm 147 23 moving move VBG work_fzrpauvhvnexhintldqhzusndm 147 24 into into IN work_fzrpauvhvnexhintldqhzusndm 147 25 production production NN work_fzrpauvhvnexhintldqhzusndm 147 26 . . . work_fzrpauvhvnexhintldqhzusndm 148 1 KPIs kpi NNS work_fzrpauvhvnexhintldqhzusndm 148 2 are be VBP work_fzrpauvhvnexhintldqhzusndm 148 3 determined determine VBN work_fzrpauvhvnexhintldqhzusndm 148 4 by by IN work_fzrpauvhvnexhintldqhzusndm 148 5 investigators investigator NNS work_fzrpauvhvnexhintldqhzusndm 148 6 but but CC work_fzrpauvhvnexhintldqhzusndm 148 7 could could MD work_fzrpauvhvnexhintldqhzusndm 148 8 include include VB work_fzrpauvhvnexhintldqhzusndm 148 9 standard standard JJ work_fzrpauvhvnexhintldqhzusndm 148 10 quality quality NN work_fzrpauvhvnexhintldqhzusndm 148 11 control control NN work_fzrpauvhvnexhintldqhzusndm 148 12 metrics metric NNS work_fzrpauvhvnexhintldqhzusndm 148 13 published publish VBN work_fzrpauvhvnexhintldqhzusndm 148 14 in in IN work_fzrpauvhvnexhintldqhzusndm 148 15 the the DT work_fzrpauvhvnexhintldqhzusndm 148 16 medical medical JJ work_fzrpauvhvnexhintldqhzusndm 148 17 literature literature NN work_fzrpauvhvnexhintldqhzusndm 148 18 . . . work_fzrpauvhvnexhintldqhzusndm 149 1 The the DT work_fzrpauvhvnexhintldqhzusndm 149 2 process process NN work_fzrpauvhvnexhintldqhzusndm 149 3 is be VBZ work_fzrpauvhvnexhintldqhzusndm 149 4 iterative iterative JJ work_fzrpauvhvnexhintldqhzusndm 149 5 , , , work_fzrpauvhvnexhintldqhzusndm 149 6 so so RB work_fzrpauvhvnexhintldqhzusndm 149 7 the the DT work_fzrpauvhvnexhintldqhzusndm 149 8 methodology methodology NN work_fzrpauvhvnexhintldqhzusndm 149 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 149 10 optimized optimize VBN work_fzrpauvhvnexhintldqhzusndm 149 11 if if IN work_fzrpauvhvnexhintldqhzusndm 149 12 KPIs kpi NNS work_fzrpauvhvnexhintldqhzusndm 149 13 are be VBP work_fzrpauvhvnexhintldqhzusndm 149 14 not not RB work_fzrpauvhvnexhintldqhzusndm 149 15 achieved achieve VBN work_fzrpauvhvnexhintldqhzusndm 149 16 , , , work_fzrpauvhvnexhintldqhzusndm 149 17 and and CC work_fzrpauvhvnexhintldqhzusndm 149 18 proceed proceed VB work_fzrpauvhvnexhintldqhzusndm 149 19 through through IN work_fzrpauvhvnexhintldqhzusndm 149 20 re re NN work_fzrpauvhvnexhintldqhzusndm 149 21 - - NN work_fzrpauvhvnexhintldqhzusndm 149 22 testing testing NN work_fzrpauvhvnexhintldqhzusndm 149 23 until until IN work_fzrpauvhvnexhintldqhzusndm 149 24 targets target NNS work_fzrpauvhvnexhintldqhzusndm 149 25 are be VBP work_fzrpauvhvnexhintldqhzusndm 149 26 met meet VBN work_fzrpauvhvnexhintldqhzusndm 149 27 . . . work_fzrpauvhvnexhintldqhzusndm 150 1 5.2 5.2 CD work_fzrpauvhvnexhintldqhzusndm 150 2 . . . work_fzrpauvhvnexhintldqhzusndm 151 1 Data Data NNPS work_fzrpauvhvnexhintldqhzusndm 151 2 Collection Collection NNP work_fzrpauvhvnexhintldqhzusndm 151 3 Researchers researcher NNS work_fzrpauvhvnexhintldqhzusndm 151 4 should should MD work_fzrpauvhvnexhintldqhzusndm 151 5 identify identify VB work_fzrpauvhvnexhintldqhzusndm 151 6 data datum NNS work_fzrpauvhvnexhintldqhzusndm 151 7 which which WDT work_fzrpauvhvnexhintldqhzusndm 151 8 may may MD work_fzrpauvhvnexhintldqhzusndm 151 9 be be VB work_fzrpauvhvnexhintldqhzusndm 151 10 important important JJ work_fzrpauvhvnexhintldqhzusndm 151 11 to to IN work_fzrpauvhvnexhintldqhzusndm 151 12 downstream downstream JJ work_fzrpauvhvnexhintldqhzusndm 151 13 quality quality NN work_fzrpauvhvnexhintldqhzusndm 151 14 control control NN work_fzrpauvhvnexhintldqhzusndm 151 15 . . . work_fzrpauvhvnexhintldqhzusndm 152 1 For for IN work_fzrpauvhvnexhintldqhzusndm 152 2 instance instance NN work_fzrpauvhvnexhintldqhzusndm 152 3 , , , work_fzrpauvhvnexhintldqhzusndm 152 4 tracking track VBG work_fzrpauvhvnexhintldqhzusndm 152 5 the the DT work_fzrpauvhvnexhintldqhzusndm 152 6 information information NN work_fzrpauvhvnexhintldqhzusndm 152 7 about about IN work_fzrpauvhvnexhintldqhzusndm 152 8 storage storage NN work_fzrpauvhvnexhintldqhzusndm 152 9 conditions condition NNS work_fzrpauvhvnexhintldqhzusndm 152 10 of of IN work_fzrpauvhvnexhintldqhzusndm 152 11 a a DT work_fzrpauvhvnexhintldqhzusndm 152 12 sample sample NN work_fzrpauvhvnexhintldqhzusndm 152 13 , , , work_fzrpauvhvnexhintldqhzusndm 152 14 or or CC work_fzrpauvhvnexhintldqhzusndm 152 15 the the DT work_fzrpauvhvnexhintldqhzusndm 152 16 time time NN work_fzrpauvhvnexhintldqhzusndm 152 17 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 152 18 takes take VBZ work_fzrpauvhvnexhintldqhzusndm 152 19 for for IN work_fzrpauvhvnexhintldqhzusndm 152 20 the the DT work_fzrpauvhvnexhintldqhzusndm 152 21 sample sample NN work_fzrpauvhvnexhintldqhzusndm 152 22 collection collection NN work_fzrpauvhvnexhintldqhzusndm 152 23 , , , work_fzrpauvhvnexhintldqhzusndm 152 24 not not RB work_fzrpauvhvnexhintldqhzusndm 152 25 only only RB work_fzrpauvhvnexhintldqhzusndm 152 26 informs inform VBZ work_fzrpauvhvnexhintldqhzusndm 152 27 about about IN work_fzrpauvhvnexhintldqhzusndm 152 28 its -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 152 29 quality quality NN work_fzrpauvhvnexhintldqhzusndm 152 30 but but CC work_fzrpauvhvnexhintldqhzusndm 152 31 also also RB work_fzrpauvhvnexhintldqhzusndm 152 32 can can MD work_fzrpauvhvnexhintldqhzusndm 152 33 help help VB work_fzrpauvhvnexhintldqhzusndm 152 34 discriminate discriminate VB work_fzrpauvhvnexhintldqhzusndm 152 35 outliers outlier NNS work_fzrpauvhvnexhintldqhzusndm 152 36 from from IN work_fzrpauvhvnexhintldqhzusndm 152 37 subjects subject NNS work_fzrpauvhvnexhintldqhzusndm 152 38 showing show VBG work_fzrpauvhvnexhintldqhzusndm 152 39 meaningful meaningful JJ work_fzrpauvhvnexhintldqhzusndm 152 40 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 152 41 differences difference NNS work_fzrpauvhvnexhintldqhzusndm 152 42 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 152 43 34 34 CD work_fzrpauvhvnexhintldqhzusndm 152 44 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 152 45 . . . work_fzrpauvhvnexhintldqhzusndm 153 1 It -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 153 2 is be VBZ work_fzrpauvhvnexhintldqhzusndm 153 3 also also RB work_fzrpauvhvnexhintldqhzusndm 153 4 very very RB work_fzrpauvhvnexhintldqhzusndm 153 5 important important JJ work_fzrpauvhvnexhintldqhzusndm 153 6 to to TO work_fzrpauvhvnexhintldqhzusndm 153 7 record record VB work_fzrpauvhvnexhintldqhzusndm 153 8 the the DT work_fzrpauvhvnexhintldqhzusndm 153 9 right right JJ work_fzrpauvhvnexhintldqhzusndm 153 10 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 153 11 about about IN work_fzrpauvhvnexhintldqhzusndm 153 12 the the DT work_fzrpauvhvnexhintldqhzusndm 153 13 study study NN work_fzrpauvhvnexhintldqhzusndm 153 14 subjects subject NNS work_fzrpauvhvnexhintldqhzusndm 153 15 as as IN work_fzrpauvhvnexhintldqhzusndm 153 16 this this DT work_fzrpauvhvnexhintldqhzusndm 153 17 will will MD work_fzrpauvhvnexhintldqhzusndm 153 18 be be VB work_fzrpauvhvnexhintldqhzusndm 153 19 one one CD work_fzrpauvhvnexhintldqhzusndm 153 20 of of IN work_fzrpauvhvnexhintldqhzusndm 153 21 the the DT work_fzrpauvhvnexhintldqhzusndm 153 22 major major JJ work_fzrpauvhvnexhintldqhzusndm 153 23 components component NNS work_fzrpauvhvnexhintldqhzusndm 153 24 of of IN work_fzrpauvhvnexhintldqhzusndm 153 25 the the DT work_fzrpauvhvnexhintldqhzusndm 153 26 multiomic multiomic NNP work_fzrpauvhvnexhintldqhzusndm 153 27 data data NNP work_fzrpauvhvnexhintldqhzusndm 153 28 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 153 29 . . . work_fzrpauvhvnexhintldqhzusndm 154 1 Correlations correlation NNS work_fzrpauvhvnexhintldqhzusndm 154 2 between between IN work_fzrpauvhvnexhintldqhzusndm 154 3 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 154 4 data datum NNS work_fzrpauvhvnexhintldqhzusndm 154 5 and and CC work_fzrpauvhvnexhintldqhzusndm 154 6 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 154 7 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 154 8 often often RB work_fzrpauvhvnexhintldqhzusndm 154 9 make make VBP work_fzrpauvhvnexhintldqhzusndm 154 10 up up RP work_fzrpauvhvnexhintldqhzusndm 154 11 a a DT work_fzrpauvhvnexhintldqhzusndm 154 12 major major JJ work_fzrpauvhvnexhintldqhzusndm 154 13 portion portion NN work_fzrpauvhvnexhintldqhzusndm 154 14 of of IN work_fzrpauvhvnexhintldqhzusndm 154 15 the the DT work_fzrpauvhvnexhintldqhzusndm 154 16 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 154 17 , , , work_fzrpauvhvnexhintldqhzusndm 154 18 which which WDT work_fzrpauvhvnexhintldqhzusndm 154 19 is be VBZ work_fzrpauvhvnexhintldqhzusndm 154 20 why why WRB work_fzrpauvhvnexhintldqhzusndm 154 21 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 154 22 is be VBZ work_fzrpauvhvnexhintldqhzusndm 154 23 extremely extremely RB work_fzrpauvhvnexhintldqhzusndm 154 24 important important JJ work_fzrpauvhvnexhintldqhzusndm 154 25 to to TO work_fzrpauvhvnexhintldqhzusndm 154 26 put put VB work_fzrpauvhvnexhintldqhzusndm 154 27 careful careful JJ work_fzrpauvhvnexhintldqhzusndm 154 28 consideration consideration NN work_fzrpauvhvnexhintldqhzusndm 154 29 into into IN work_fzrpauvhvnexhintldqhzusndm 154 30 what what WDT work_fzrpauvhvnexhintldqhzusndm 154 31 information information NN work_fzrpauvhvnexhintldqhzusndm 154 32 will will MD work_fzrpauvhvnexhintldqhzusndm 154 33 be be VB work_fzrpauvhvnexhintldqhzusndm 154 34 collected collect VBN work_fzrpauvhvnexhintldqhzusndm 154 35 prior prior RB work_fzrpauvhvnexhintldqhzusndm 154 36 to to IN work_fzrpauvhvnexhintldqhzusndm 154 37 enrollment enrollment NN work_fzrpauvhvnexhintldqhzusndm 154 38 of of IN work_fzrpauvhvnexhintldqhzusndm 154 39 the the DT work_fzrpauvhvnexhintldqhzusndm 154 40 participants participant NNS work_fzrpauvhvnexhintldqhzusndm 154 41 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 154 42 35 35 CD work_fzrpauvhvnexhintldqhzusndm 154 43 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 154 44 . . . work_fzrpauvhvnexhintldqhzusndm 155 1 These these DT work_fzrpauvhvnexhintldqhzusndm 155 2 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 155 3 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 155 4 are be VBP work_fzrpauvhvnexhintldqhzusndm 155 5 study study NN work_fzrpauvhvnexhintldqhzusndm 155 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 155 7 specific specific JJ work_fzrpauvhvnexhintldqhzusndm 155 8 Challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 155 9 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 155 10 , , , work_fzrpauvhvnexhintldqhzusndm 155 11 10 10 CD work_fzrpauvhvnexhintldqhzusndm 155 12 , , , work_fzrpauvhvnexhintldqhzusndm 155 13 23 23 CD work_fzrpauvhvnexhintldqhzusndm 155 14 6 6 CD work_fzrpauvhvnexhintldqhzusndm 155 15 of of IN work_fzrpauvhvnexhintldqhzusndm 155 16 9 9 CD work_fzrpauvhvnexhintldqhzusndm 155 17 and and CC work_fzrpauvhvnexhintldqhzusndm 155 18 depend depend VB work_fzrpauvhvnexhintldqhzusndm 155 19 on on IN work_fzrpauvhvnexhintldqhzusndm 155 20 the the DT work_fzrpauvhvnexhintldqhzusndm 155 21 nature nature NN work_fzrpauvhvnexhintldqhzusndm 155 22 of of IN work_fzrpauvhvnexhintldqhzusndm 155 23 the the DT work_fzrpauvhvnexhintldqhzusndm 155 24 disease disease NN work_fzrpauvhvnexhintldqhzusndm 155 25 or or CC work_fzrpauvhvnexhintldqhzusndm 155 26 the the DT work_fzrpauvhvnexhintldqhzusndm 155 27 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 155 28 question question NN work_fzrpauvhvnexhintldqhzusndm 155 29 asked ask VBD work_fzrpauvhvnexhintldqhzusndm 155 30 . . . work_fzrpauvhvnexhintldqhzusndm 156 1 The the DT work_fzrpauvhvnexhintldqhzusndm 156 2 identification identification NN work_fzrpauvhvnexhintldqhzusndm 156 3 of of IN work_fzrpauvhvnexhintldqhzusndm 156 4 the the DT work_fzrpauvhvnexhintldqhzusndm 156 5 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 156 6 types type NNS work_fzrpauvhvnexhintldqhzusndm 156 7 can can MD work_fzrpauvhvnexhintldqhzusndm 156 8 be be VB work_fzrpauvhvnexhintldqhzusndm 156 9 challenging challenge VBG work_fzrpauvhvnexhintldqhzusndm 156 10 when when WRB work_fzrpauvhvnexhintldqhzusndm 156 11 looking look VBG work_fzrpauvhvnexhintldqhzusndm 156 12 at at IN work_fzrpauvhvnexhintldqhzusndm 156 13 the the DT work_fzrpauvhvnexhintldqhzusndm 156 14 impact impact NN work_fzrpauvhvnexhintldqhzusndm 156 15 of of IN work_fzrpauvhvnexhintldqhzusndm 156 16 sociodemographic sociodemographic JJ work_fzrpauvhvnexhintldqhzusndm 156 17 changes change NNS work_fzrpauvhvnexhintldqhzusndm 156 18 and and CC work_fzrpauvhvnexhintldqhzusndm 156 19 modernity modernity NN work_fzrpauvhvnexhintldqhzusndm 156 20 on on IN work_fzrpauvhvnexhintldqhzusndm 156 21 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 156 22 development development NN work_fzrpauvhvnexhintldqhzusndm 156 23 dysregulation dysregulation NN work_fzrpauvhvnexhintldqhzusndm 156 24 . . . work_fzrpauvhvnexhintldqhzusndm 157 1 For for IN work_fzrpauvhvnexhintldqhzusndm 157 2 instance instance NN work_fzrpauvhvnexhintldqhzusndm 157 3 , , , work_fzrpauvhvnexhintldqhzusndm 157 4 a a DT work_fzrpauvhvnexhintldqhzusndm 157 5 study study NN work_fzrpauvhvnexhintldqhzusndm 157 6 of of IN work_fzrpauvhvnexhintldqhzusndm 157 7 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 157 8 development development NN work_fzrpauvhvnexhintldqhzusndm 157 9 of of IN work_fzrpauvhvnexhintldqhzusndm 157 10 neonates neonate NNS work_fzrpauvhvnexhintldqhzusndm 157 11 should should MD work_fzrpauvhvnexhintldqhzusndm 157 12 consider consider VB work_fzrpauvhvnexhintldqhzusndm 157 13 prenatal prenatal JJ work_fzrpauvhvnexhintldqhzusndm 157 14 and and CC work_fzrpauvhvnexhintldqhzusndm 157 15 parental parental JJ work_fzrpauvhvnexhintldqhzusndm 157 16 variations variation NNS work_fzrpauvhvnexhintldqhzusndm 157 17 in in IN work_fzrpauvhvnexhintldqhzusndm 157 18 environments environment NNS work_fzrpauvhvnexhintldqhzusndm 157 19 , , , work_fzrpauvhvnexhintldqhzusndm 157 20 nutrition nutrition NN work_fzrpauvhvnexhintldqhzusndm 157 21 , , , work_fzrpauvhvnexhintldqhzusndm 157 22 lifestyle lifestyle NN work_fzrpauvhvnexhintldqhzusndm 157 23 , , , work_fzrpauvhvnexhintldqhzusndm 157 24 age age NN work_fzrpauvhvnexhintldqhzusndm 157 25 at at IN work_fzrpauvhvnexhintldqhzusndm 157 26 conception conception NN work_fzrpauvhvnexhintldqhzusndm 157 27 , , , work_fzrpauvhvnexhintldqhzusndm 157 28 delivery delivery NN work_fzrpauvhvnexhintldqhzusndm 157 29 mode mode NN work_fzrpauvhvnexhintldqhzusndm 157 30 , , , work_fzrpauvhvnexhintldqhzusndm 157 31 and and CC work_fzrpauvhvnexhintldqhzusndm 157 32 many many JJ work_fzrpauvhvnexhintldqhzusndm 157 33 other other JJ work_fzrpauvhvnexhintldqhzusndm 157 34 factors factor NNS work_fzrpauvhvnexhintldqhzusndm 157 35 . . . work_fzrpauvhvnexhintldqhzusndm 158 1 All all DT work_fzrpauvhvnexhintldqhzusndm 158 2 of of IN work_fzrpauvhvnexhintldqhzusndm 158 3 these these DT work_fzrpauvhvnexhintldqhzusndm 158 4 could could MD work_fzrpauvhvnexhintldqhzusndm 158 5 be be VB work_fzrpauvhvnexhintldqhzusndm 158 6 a a DT work_fzrpauvhvnexhintldqhzusndm 158 7 driving drive VBG work_fzrpauvhvnexhintldqhzusndm 158 8 force force NN work_fzrpauvhvnexhintldqhzusndm 158 9 behind behind IN work_fzrpauvhvnexhintldqhzusndm 158 10 different different JJ work_fzrpauvhvnexhintldqhzusndm 158 11 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 158 12 signatures signature NNS work_fzrpauvhvnexhintldqhzusndm 158 13 revealed reveal VBN work_fzrpauvhvnexhintldqhzusndm 158 14 by by IN work_fzrpauvhvnexhintldqhzusndm 158 15 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 158 16 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 158 17 . . . work_fzrpauvhvnexhintldqhzusndm 159 1 By by IN work_fzrpauvhvnexhintldqhzusndm 159 2 combining combine VBG work_fzrpauvhvnexhintldqhzusndm 159 3 data datum NNS work_fzrpauvhvnexhintldqhzusndm 159 4 types type NNS work_fzrpauvhvnexhintldqhzusndm 159 5 , , , work_fzrpauvhvnexhintldqhzusndm 159 6 we -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 159 7 should should MD work_fzrpauvhvnexhintldqhzusndm 159 8 be be VB work_fzrpauvhvnexhintldqhzusndm 159 9 able able JJ work_fzrpauvhvnexhintldqhzusndm 159 10 to to TO work_fzrpauvhvnexhintldqhzusndm 159 11 see see VB work_fzrpauvhvnexhintldqhzusndm 159 12 the the DT work_fzrpauvhvnexhintldqhzusndm 159 13 full full JJ work_fzrpauvhvnexhintldqhzusndm 159 14 spectrum spectrum NN work_fzrpauvhvnexhintldqhzusndm 159 15 of of IN work_fzrpauvhvnexhintldqhzusndm 159 16 the the DT work_fzrpauvhvnexhintldqhzusndm 159 17 global global JJ work_fzrpauvhvnexhintldqhzusndm 159 18 impact impact NN work_fzrpauvhvnexhintldqhzusndm 159 19 of of IN work_fzrpauvhvnexhintldqhzusndm 159 20 the the DT work_fzrpauvhvnexhintldqhzusndm 159 21 environment environment NN work_fzrpauvhvnexhintldqhzusndm 159 22 changes change NNS work_fzrpauvhvnexhintldqhzusndm 159 23 on on IN work_fzrpauvhvnexhintldqhzusndm 159 24 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 159 25 development development NN work_fzrpauvhvnexhintldqhzusndm 159 26 in in IN work_fzrpauvhvnexhintldqhzusndm 159 27 an an DT work_fzrpauvhvnexhintldqhzusndm 159 28 unprecedented unprecedented JJ work_fzrpauvhvnexhintldqhzusndm 159 29 manner manner NN work_fzrpauvhvnexhintldqhzusndm 159 30 , , , work_fzrpauvhvnexhintldqhzusndm 159 31 by by IN work_fzrpauvhvnexhintldqhzusndm 159 32 leveraging leverage VBG work_fzrpauvhvnexhintldqhzusndm 159 33 the the DT work_fzrpauvhvnexhintldqhzusndm 159 34 power power NN work_fzrpauvhvnexhintldqhzusndm 159 35 of of IN work_fzrpauvhvnexhintldqhzusndm 159 36 data datum NNS work_fzrpauvhvnexhintldqhzusndm 159 37 integration integration NN work_fzrpauvhvnexhintldqhzusndm 159 38 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 159 39 36 36 CD work_fzrpauvhvnexhintldqhzusndm 159 40 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 159 41 . . . work_fzrpauvhvnexhintldqhzusndm 160 1 5.3 5.3 CD work_fzrpauvhvnexhintldqhzusndm 160 2 . . . work_fzrpauvhvnexhintldqhzusndm 161 1 Data Data NNP work_fzrpauvhvnexhintldqhzusndm 161 2 Management Management NNP work_fzrpauvhvnexhintldqhzusndm 161 3 Appropriately appropriately RB work_fzrpauvhvnexhintldqhzusndm 161 4 managing manage VBG work_fzrpauvhvnexhintldqhzusndm 161 5 the the DT work_fzrpauvhvnexhintldqhzusndm 161 6 generated generate VBN work_fzrpauvhvnexhintldqhzusndm 161 7 information information NN work_fzrpauvhvnexhintldqhzusndm 161 8 , , , work_fzrpauvhvnexhintldqhzusndm 161 9 collecting collect VBG work_fzrpauvhvnexhintldqhzusndm 161 10 the the DT work_fzrpauvhvnexhintldqhzusndm 161 11 appropriate appropriate JJ work_fzrpauvhvnexhintldqhzusndm 161 12 metrics metric NNS work_fzrpauvhvnexhintldqhzusndm 161 13 , , , work_fzrpauvhvnexhintldqhzusndm 161 14 centralizing centralize VBG work_fzrpauvhvnexhintldqhzusndm 161 15 the the DT work_fzrpauvhvnexhintldqhzusndm 161 16 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 161 17 pipelines pipeline NNS work_fzrpauvhvnexhintldqhzusndm 161 18 , , , work_fzrpauvhvnexhintldqhzusndm 161 19 and and CC work_fzrpauvhvnexhintldqhzusndm 161 20 standardizing standardize VBG work_fzrpauvhvnexhintldqhzusndm 161 21 the the DT work_fzrpauvhvnexhintldqhzusndm 161 22 entire entire JJ work_fzrpauvhvnexhintldqhzusndm 161 23 process process NN work_fzrpauvhvnexhintldqhzusndm 161 24 are be VBP work_fzrpauvhvnexhintldqhzusndm 161 25 key key JJ work_fzrpauvhvnexhintldqhzusndm 161 26 fundamental fundamental JJ work_fzrpauvhvnexhintldqhzusndm 161 27 steps step NNS work_fzrpauvhvnexhintldqhzusndm 161 28 that that WDT work_fzrpauvhvnexhintldqhzusndm 161 29 are be VBP work_fzrpauvhvnexhintldqhzusndm 161 30 not not RB work_fzrpauvhvnexhintldqhzusndm 161 31 easy easy JJ work_fzrpauvhvnexhintldqhzusndm 161 32 to to TO work_fzrpauvhvnexhintldqhzusndm 161 33 implement implement VB work_fzrpauvhvnexhintldqhzusndm 161 34 in in IN work_fzrpauvhvnexhintldqhzusndm 161 35 large large JJ work_fzrpauvhvnexhintldqhzusndm 161 36 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 161 37 studies study NNS work_fzrpauvhvnexhintldqhzusndm 161 38 . . . work_fzrpauvhvnexhintldqhzusndm 162 1 A a DT work_fzrpauvhvnexhintldqhzusndm 162 2 first first JJ work_fzrpauvhvnexhintldqhzusndm 162 3 line line NN work_fzrpauvhvnexhintldqhzusndm 162 4 challenge challenge NN work_fzrpauvhvnexhintldqhzusndm 162 5 in in IN work_fzrpauvhvnexhintldqhzusndm 162 6 any any DT work_fzrpauvhvnexhintldqhzusndm 162 7 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 162 8 study study NN work_fzrpauvhvnexhintldqhzusndm 162 9 involves involve VBZ work_fzrpauvhvnexhintldqhzusndm 162 10 devising devise VBG work_fzrpauvhvnexhintldqhzusndm 162 11 an an DT work_fzrpauvhvnexhintldqhzusndm 162 12 appropriate appropriate JJ work_fzrpauvhvnexhintldqhzusndm 162 13 strategy strategy NN work_fzrpauvhvnexhintldqhzusndm 162 14 to to TO work_fzrpauvhvnexhintldqhzusndm 162 15 store store VB work_fzrpauvhvnexhintldqhzusndm 162 16 , , , work_fzrpauvhvnexhintldqhzusndm 162 17 index index NN work_fzrpauvhvnexhintldqhzusndm 162 18 , , , work_fzrpauvhvnexhintldqhzusndm 162 19 organize organize VB work_fzrpauvhvnexhintldqhzusndm 162 20 , , , work_fzrpauvhvnexhintldqhzusndm 162 21 audit audit NN work_fzrpauvhvnexhintldqhzusndm 162 22 , , , work_fzrpauvhvnexhintldqhzusndm 162 23 distribute distribute VB work_fzrpauvhvnexhintldqhzusndm 162 24 , , , work_fzrpauvhvnexhintldqhzusndm 162 25 and and CC work_fzrpauvhvnexhintldqhzusndm 162 26 archive archive JJ work_fzrpauvhvnexhintldqhzusndm 162 27 vast vast JJ work_fzrpauvhvnexhintldqhzusndm 162 28 amounts amount NNS work_fzrpauvhvnexhintldqhzusndm 162 29 of of IN work_fzrpauvhvnexhintldqhzusndm 162 30 big big JJ work_fzrpauvhvnexhintldqhzusndm 162 31 data datum NNS work_fzrpauvhvnexhintldqhzusndm 162 32 . . . work_fzrpauvhvnexhintldqhzusndm 163 1 Initiatives initiative NNS work_fzrpauvhvnexhintldqhzusndm 163 2 such such JJ work_fzrpauvhvnexhintldqhzusndm 163 3 as as IN work_fzrpauvhvnexhintldqhzusndm 163 4 the the DT work_fzrpauvhvnexhintldqhzusndm 163 5 open open JJ work_fzrpauvhvnexhintldqhzusndm 163 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 163 7 source source NN work_fzrpauvhvnexhintldqhzusndm 163 8 integrated integrate VBN work_fzrpauvhvnexhintldqhzusndm 163 9 Rule Rule NNP work_fzrpauvhvnexhintldqhzusndm 163 10 Orientated Orientated NNP work_fzrpauvhvnexhintldqhzusndm 163 11 Data Data NNPS work_fzrpauvhvnexhintldqhzusndm 163 12 Systems Systems NNP work_fzrpauvhvnexhintldqhzusndm 163 13 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 163 14 iRODS irods NN work_fzrpauvhvnexhintldqhzusndm 163 15 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 163 16 provide provide VBP work_fzrpauvhvnexhintldqhzusndm 163 17 an an DT work_fzrpauvhvnexhintldqhzusndm 163 18 overall overall JJ work_fzrpauvhvnexhintldqhzusndm 163 19 framework framework NN work_fzrpauvhvnexhintldqhzusndm 163 20 for for IN work_fzrpauvhvnexhintldqhzusndm 163 21 data data NN work_fzrpauvhvnexhintldqhzusndm 163 22 management management NN work_fzrpauvhvnexhintldqhzusndm 163 23 tasks task NNS work_fzrpauvhvnexhintldqhzusndm 163 24 and and CC work_fzrpauvhvnexhintldqhzusndm 163 25 allow allow VB work_fzrpauvhvnexhintldqhzusndm 163 26 complete complete JJ work_fzrpauvhvnexhintldqhzusndm 163 27 management management NN work_fzrpauvhvnexhintldqhzusndm 163 28 of of IN work_fzrpauvhvnexhintldqhzusndm 163 29 primary primary NN work_fzrpauvhvnexhintldqhzusndm 163 30 and and CC work_fzrpauvhvnexhintldqhzusndm 163 31 derived derive VBN work_fzrpauvhvnexhintldqhzusndm 163 32 data datum NNS work_fzrpauvhvnexhintldqhzusndm 163 33 with with IN work_fzrpauvhvnexhintldqhzusndm 163 34 rules rule NNS work_fzrpauvhvnexhintldqhzusndm 163 35 and and CC work_fzrpauvhvnexhintldqhzusndm 163 36 policies policy NNS work_fzrpauvhvnexhintldqhzusndm 163 37 to to TO work_fzrpauvhvnexhintldqhzusndm 163 38 ensure ensure VB work_fzrpauvhvnexhintldqhzusndm 163 39 reproducibility reproducibility NN work_fzrpauvhvnexhintldqhzusndm 163 40 of of IN work_fzrpauvhvnexhintldqhzusndm 163 41 the the DT work_fzrpauvhvnexhintldqhzusndm 163 42 research research NN work_fzrpauvhvnexhintldqhzusndm 163 43 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 163 44 37 37 CD work_fzrpauvhvnexhintldqhzusndm 163 45 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 163 46 . . . work_fzrpauvhvnexhintldqhzusndm 164 1 This this DT work_fzrpauvhvnexhintldqhzusndm 164 2 includes include VBZ work_fzrpauvhvnexhintldqhzusndm 164 3 attaching attach VBG work_fzrpauvhvnexhintldqhzusndm 164 4 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 164 5 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 164 6 and and CC work_fzrpauvhvnexhintldqhzusndm 164 7 metrics metric NNS work_fzrpauvhvnexhintldqhzusndm 164 8 , , , work_fzrpauvhvnexhintldqhzusndm 164 9 covering cover VBG work_fzrpauvhvnexhintldqhzusndm 164 10 the the DT work_fzrpauvhvnexhintldqhzusndm 164 11 entire entire JJ work_fzrpauvhvnexhintldqhzusndm 164 12 range range NN work_fzrpauvhvnexhintldqhzusndm 164 13 of of IN work_fzrpauvhvnexhintldqhzusndm 164 14 steps step NNS work_fzrpauvhvnexhintldqhzusndm 164 15 from from IN work_fzrpauvhvnexhintldqhzusndm 164 16 the the DT work_fzrpauvhvnexhintldqhzusndm 164 17 bio bio JJ work_fzrpauvhvnexhintldqhzusndm 164 18 - - JJ work_fzrpauvhvnexhintldqhzusndm 164 19 sample sample JJ work_fzrpauvhvnexhintldqhzusndm 164 20 collection collection NN work_fzrpauvhvnexhintldqhzusndm 164 21 to to IN work_fzrpauvhvnexhintldqhzusndm 164 22 processing processing NN work_fzrpauvhvnexhintldqhzusndm 164 23 of of IN work_fzrpauvhvnexhintldqhzusndm 164 24 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 164 25 data data NN work_fzrpauvhvnexhintldqhzusndm 164 26 files file NNS work_fzrpauvhvnexhintldqhzusndm 164 27 . . . work_fzrpauvhvnexhintldqhzusndm 165 1 Without without IN work_fzrpauvhvnexhintldqhzusndm 165 2 a a DT work_fzrpauvhvnexhintldqhzusndm 165 3 pre pre JJ work_fzrpauvhvnexhintldqhzusndm 165 4 - - VBN work_fzrpauvhvnexhintldqhzusndm 165 5 defined define VBN work_fzrpauvhvnexhintldqhzusndm 165 6 strategy strategy NN work_fzrpauvhvnexhintldqhzusndm 165 7 to to TO work_fzrpauvhvnexhintldqhzusndm 165 8 build build VB work_fzrpauvhvnexhintldqhzusndm 165 9 a a DT work_fzrpauvhvnexhintldqhzusndm 165 10 common common JJ work_fzrpauvhvnexhintldqhzusndm 165 11 infrastructure infrastructure NN work_fzrpauvhvnexhintldqhzusndm 165 12 for for IN work_fzrpauvhvnexhintldqhzusndm 165 13 data datum NNS work_fzrpauvhvnexhintldqhzusndm 165 14 storage storage NN work_fzrpauvhvnexhintldqhzusndm 165 15 , , , work_fzrpauvhvnexhintldqhzusndm 165 16 accessibility accessibility NN work_fzrpauvhvnexhintldqhzusndm 165 17 , , , work_fzrpauvhvnexhintldqhzusndm 165 18 and and CC work_fzrpauvhvnexhintldqhzusndm 165 19 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 165 20 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 165 21 e.g. e.g. RB work_fzrpauvhvnexhintldqhzusndm 165 22 , , , work_fzrpauvhvnexhintldqhzusndm 165 23 code code NN work_fzrpauvhvnexhintldqhzusndm 165 24 reviewing reviewing NN work_fzrpauvhvnexhintldqhzusndm 165 25 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 165 26 , , , work_fzrpauvhvnexhintldqhzusndm 165 27 the the DT work_fzrpauvhvnexhintldqhzusndm 165 28 data datum NNS work_fzrpauvhvnexhintldqhzusndm 165 29 integrity integrity NN work_fzrpauvhvnexhintldqhzusndm 165 30 backing back VBG work_fzrpauvhvnexhintldqhzusndm 165 31 the the DT work_fzrpauvhvnexhintldqhzusndm 165 32 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 165 33 insight insight NN work_fzrpauvhvnexhintldqhzusndm 165 34 can can MD work_fzrpauvhvnexhintldqhzusndm 165 35 quickly quickly RB work_fzrpauvhvnexhintldqhzusndm 165 36 be be VB work_fzrpauvhvnexhintldqhzusndm 165 37 jeopardized jeopardize VBN work_fzrpauvhvnexhintldqhzusndm 165 38 . . . work_fzrpauvhvnexhintldqhzusndm 166 1 In in IN work_fzrpauvhvnexhintldqhzusndm 166 2 fact fact NN work_fzrpauvhvnexhintldqhzusndm 166 3 , , , work_fzrpauvhvnexhintldqhzusndm 166 4 the the DT work_fzrpauvhvnexhintldqhzusndm 166 5 massive massive JJ work_fzrpauvhvnexhintldqhzusndm 166 6 amount amount NN work_fzrpauvhvnexhintldqhzusndm 166 7 of of IN work_fzrpauvhvnexhintldqhzusndm 166 8 data datum NNS work_fzrpauvhvnexhintldqhzusndm 166 9 generated generate VBN work_fzrpauvhvnexhintldqhzusndm 166 10 needs need NNS work_fzrpauvhvnexhintldqhzusndm 166 11 to to TO work_fzrpauvhvnexhintldqhzusndm 166 12 be be VB work_fzrpauvhvnexhintldqhzusndm 166 13 first first RB work_fzrpauvhvnexhintldqhzusndm 166 14 verified verify VBN work_fzrpauvhvnexhintldqhzusndm 166 15 for for IN work_fzrpauvhvnexhintldqhzusndm 166 16 quality quality NN work_fzrpauvhvnexhintldqhzusndm 166 17 control control NN work_fzrpauvhvnexhintldqhzusndm 166 18 purposes purpose NNS work_fzrpauvhvnexhintldqhzusndm 166 19 , , , work_fzrpauvhvnexhintldqhzusndm 166 20 and and CC work_fzrpauvhvnexhintldqhzusndm 166 21 cleaned clean VBD work_fzrpauvhvnexhintldqhzusndm 166 22 prior prior RB work_fzrpauvhvnexhintldqhzusndm 166 23 to to IN work_fzrpauvhvnexhintldqhzusndm 166 24 being be VBG work_fzrpauvhvnexhintldqhzusndm 166 25 analyzed analyze VBN work_fzrpauvhvnexhintldqhzusndm 166 26 in in IN work_fzrpauvhvnexhintldqhzusndm 166 27 a a DT work_fzrpauvhvnexhintldqhzusndm 166 28 transparent transparent JJ work_fzrpauvhvnexhintldqhzusndm 166 29 and and CC work_fzrpauvhvnexhintldqhzusndm 166 30 reproducible reproducible NN work_fzrpauvhvnexhintldqhzusndm 166 31 manner manner NN work_fzrpauvhvnexhintldqhzusndm 166 32 amongst amongst IN work_fzrpauvhvnexhintldqhzusndm 166 33 the the DT work_fzrpauvhvnexhintldqhzusndm 166 34 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 166 35 study study NN work_fzrpauvhvnexhintldqhzusndm 166 36 experts expert NNS work_fzrpauvhvnexhintldqhzusndm 166 37 . . . work_fzrpauvhvnexhintldqhzusndm 167 1 A a DT work_fzrpauvhvnexhintldqhzusndm 167 2 second second JJ work_fzrpauvhvnexhintldqhzusndm 167 3 challenge challenge NN work_fzrpauvhvnexhintldqhzusndm 167 4 involves involve VBZ work_fzrpauvhvnexhintldqhzusndm 167 5 the the DT work_fzrpauvhvnexhintldqhzusndm 167 6 integration integration NN work_fzrpauvhvnexhintldqhzusndm 167 7 of of IN work_fzrpauvhvnexhintldqhzusndm 167 8 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 167 9 patient patient NN work_fzrpauvhvnexhintldqhzusndm 167 10 data datum NNS work_fzrpauvhvnexhintldqhzusndm 167 11 with with IN work_fzrpauvhvnexhintldqhzusndm 167 12 high high JJ work_fzrpauvhvnexhintldqhzusndm 167 13 - - HYPH work_fzrpauvhvnexhintldqhzusndm 167 14 dimensional dimensional JJ work_fzrpauvhvnexhintldqhzusndm 167 15 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 167 16 datasets dataset NNS work_fzrpauvhvnexhintldqhzusndm 167 17 . . . work_fzrpauvhvnexhintldqhzusndm 168 1 Software software NN work_fzrpauvhvnexhintldqhzusndm 168 2 that that WDT work_fzrpauvhvnexhintldqhzusndm 168 3 enables enable VBZ work_fzrpauvhvnexhintldqhzusndm 168 4 integration integration NN work_fzrpauvhvnexhintldqhzusndm 168 5 of of IN work_fzrpauvhvnexhintldqhzusndm 168 6 curated curate VBN work_fzrpauvhvnexhintldqhzusndm 168 7 phenotypic phenotypic JJ work_fzrpauvhvnexhintldqhzusndm 168 8 data datum NNS work_fzrpauvhvnexhintldqhzusndm 168 9 from from IN work_fzrpauvhvnexhintldqhzusndm 168 10 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 168 11 observations observation NNS work_fzrpauvhvnexhintldqhzusndm 168 12 with with IN work_fzrpauvhvnexhintldqhzusndm 168 13 biomarker biomarker NN work_fzrpauvhvnexhintldqhzusndm 168 14 data datum NNS work_fzrpauvhvnexhintldqhzusndm 168 15 from from IN work_fzrpauvhvnexhintldqhzusndm 168 16 gene gene NN work_fzrpauvhvnexhintldqhzusndm 168 17 expression expression NN work_fzrpauvhvnexhintldqhzusndm 168 18 and and CC work_fzrpauvhvnexhintldqhzusndm 168 19 genotyping genotyping NN work_fzrpauvhvnexhintldqhzusndm 168 20 studies study NNS work_fzrpauvhvnexhintldqhzusndm 168 21 are be VBP work_fzrpauvhvnexhintldqhzusndm 168 22 emerging emerge VBG work_fzrpauvhvnexhintldqhzusndm 168 23 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 168 24 38,39 38,39 CD work_fzrpauvhvnexhintldqhzusndm 168 25 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 168 26 . . . work_fzrpauvhvnexhintldqhzusndm 169 1 In in IN work_fzrpauvhvnexhintldqhzusndm 169 2 order order NN work_fzrpauvhvnexhintldqhzusndm 169 3 for for IN work_fzrpauvhvnexhintldqhzusndm 169 4 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 169 5 studies study NNS work_fzrpauvhvnexhintldqhzusndm 169 6 to to TO work_fzrpauvhvnexhintldqhzusndm 169 7 be be VB work_fzrpauvhvnexhintldqhzusndm 169 8 reproducible reproducible JJ work_fzrpauvhvnexhintldqhzusndm 169 9 , , , work_fzrpauvhvnexhintldqhzusndm 169 10 these these DT work_fzrpauvhvnexhintldqhzusndm 169 11 computing computing NN work_fzrpauvhvnexhintldqhzusndm 169 12 and and CC work_fzrpauvhvnexhintldqhzusndm 169 13 software software NN work_fzrpauvhvnexhintldqhzusndm 169 14 infrastructures infrastructure NNS work_fzrpauvhvnexhintldqhzusndm 169 15 will will MD work_fzrpauvhvnexhintldqhzusndm 169 16 be be VB work_fzrpauvhvnexhintldqhzusndm 169 17 mission mission NN work_fzrpauvhvnexhintldqhzusndm 169 18 - - HYPH work_fzrpauvhvnexhintldqhzusndm 169 19 critical critical JJ work_fzrpauvhvnexhintldqhzusndm 169 20 over over IN work_fzrpauvhvnexhintldqhzusndm 169 21 the the DT work_fzrpauvhvnexhintldqhzusndm 169 22 long long JJ work_fzrpauvhvnexhintldqhzusndm 169 23 term term NN work_fzrpauvhvnexhintldqhzusndm 169 24 . . . work_fzrpauvhvnexhintldqhzusndm 170 1 5.4 5.4 CD work_fzrpauvhvnexhintldqhzusndm 170 2 . . . work_fzrpauvhvnexhintldqhzusndm 171 1 Data Data NNPS work_fzrpauvhvnexhintldqhzusndm 171 2 Analysis Analysis NNP work_fzrpauvhvnexhintldqhzusndm 171 3 Bioinformatic bioinformatic JJ work_fzrpauvhvnexhintldqhzusndm 171 4 approaches approach VBZ work_fzrpauvhvnexhintldqhzusndm 171 5 to to TO work_fzrpauvhvnexhintldqhzusndm 171 6 extract extract VB work_fzrpauvhvnexhintldqhzusndm 171 7 meaning meaning NN work_fzrpauvhvnexhintldqhzusndm 171 8 from from IN work_fzrpauvhvnexhintldqhzusndm 171 9 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 171 10 data datum NNS work_fzrpauvhvnexhintldqhzusndm 171 11 is be VBZ work_fzrpauvhvnexhintldqhzusndm 171 12 an an DT work_fzrpauvhvnexhintldqhzusndm 171 13 obvious obvious JJ work_fzrpauvhvnexhintldqhzusndm 171 14 challenge challenge NN work_fzrpauvhvnexhintldqhzusndm 171 15 . . . work_fzrpauvhvnexhintldqhzusndm 172 1 Most Most JJS work_fzrpauvhvnexhintldqhzusndm 172 2 of of IN work_fzrpauvhvnexhintldqhzusndm 172 3 the the DT work_fzrpauvhvnexhintldqhzusndm 172 4 unsupervised unsupervised JJ work_fzrpauvhvnexhintldqhzusndm 172 5 data datum NNS work_fzrpauvhvnexhintldqhzusndm 172 6 integration integration NN work_fzrpauvhvnexhintldqhzusndm 172 7 methods method NNS work_fzrpauvhvnexhintldqhzusndm 172 8 require require VBP work_fzrpauvhvnexhintldqhzusndm 172 9 cutting cut VBG work_fzrpauvhvnexhintldqhzusndm 172 10 edge edge NN work_fzrpauvhvnexhintldqhzusndm 172 11 tools tool NNS work_fzrpauvhvnexhintldqhzusndm 172 12 and and CC work_fzrpauvhvnexhintldqhzusndm 172 13 models model NNS work_fzrpauvhvnexhintldqhzusndm 172 14 using use VBG work_fzrpauvhvnexhintldqhzusndm 172 15 extensive extensive JJ work_fzrpauvhvnexhintldqhzusndm 172 16 computing computing NN work_fzrpauvhvnexhintldqhzusndm 172 17 capabilities capability NNS work_fzrpauvhvnexhintldqhzusndm 172 18 to to TO work_fzrpauvhvnexhintldqhzusndm 172 19 develop develop VB work_fzrpauvhvnexhintldqhzusndm 172 20 new new JJ work_fzrpauvhvnexhintldqhzusndm 172 21 algorithms algorithm NNS work_fzrpauvhvnexhintldqhzusndm 172 22 and and CC work_fzrpauvhvnexhintldqhzusndm 172 23 theoretical theoretical JJ work_fzrpauvhvnexhintldqhzusndm 172 24 methods method NNS work_fzrpauvhvnexhintldqhzusndm 172 25 that that WDT work_fzrpauvhvnexhintldqhzusndm 172 26 fit fit VBP work_fzrpauvhvnexhintldqhzusndm 172 27 the the DT work_fzrpauvhvnexhintldqhzusndm 172 28 different different JJ work_fzrpauvhvnexhintldqhzusndm 172 29 layers layer NNS work_fzrpauvhvnexhintldqhzusndm 172 30 of of IN work_fzrpauvhvnexhintldqhzusndm 172 31 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 172 32 datasets dataset NNS work_fzrpauvhvnexhintldqhzusndm 172 33 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 172 34 40,41 40,41 CD work_fzrpauvhvnexhintldqhzusndm 172 35 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 172 36 . . . work_fzrpauvhvnexhintldqhzusndm 173 1 The the DT work_fzrpauvhvnexhintldqhzusndm 173 2 challenge challenge NN work_fzrpauvhvnexhintldqhzusndm 173 3 for for IN work_fzrpauvhvnexhintldqhzusndm 173 4 data datum NNS work_fzrpauvhvnexhintldqhzusndm 173 5 integration integration NN work_fzrpauvhvnexhintldqhzusndm 173 6 is be VBZ work_fzrpauvhvnexhintldqhzusndm 173 7 to to TO work_fzrpauvhvnexhintldqhzusndm 173 8 apply apply VB work_fzrpauvhvnexhintldqhzusndm 173 9 the the DT work_fzrpauvhvnexhintldqhzusndm 173 10 appropriate appropriate JJ work_fzrpauvhvnexhintldqhzusndm 173 11 bioinformatic bioinformatic JJ work_fzrpauvhvnexhintldqhzusndm 173 12 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 173 13 to to IN work_fzrpauvhvnexhintldqhzusndm 173 14 the the DT work_fzrpauvhvnexhintldqhzusndm 173 15 study study NN work_fzrpauvhvnexhintldqhzusndm 173 16 type type NN work_fzrpauvhvnexhintldqhzusndm 173 17 and and CC work_fzrpauvhvnexhintldqhzusndm 173 18 data datum NNS work_fzrpauvhvnexhintldqhzusndm 173 19 collected collect VBN work_fzrpauvhvnexhintldqhzusndm 173 20 . . . work_fzrpauvhvnexhintldqhzusndm 174 1 Moreover moreover RB work_fzrpauvhvnexhintldqhzusndm 174 2 , , , work_fzrpauvhvnexhintldqhzusndm 174 3 the the DT work_fzrpauvhvnexhintldqhzusndm 174 4 different different JJ work_fzrpauvhvnexhintldqhzusndm 174 5 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 174 6 datasets dataset NNS work_fzrpauvhvnexhintldqhzusndm 174 7 have have VBP work_fzrpauvhvnexhintldqhzusndm 174 8 a a DT work_fzrpauvhvnexhintldqhzusndm 174 9 distinct distinct JJ work_fzrpauvhvnexhintldqhzusndm 174 10 format format NN work_fzrpauvhvnexhintldqhzusndm 174 11 , , , work_fzrpauvhvnexhintldqhzusndm 174 12 size size NN work_fzrpauvhvnexhintldqhzusndm 174 13 , , , work_fzrpauvhvnexhintldqhzusndm 174 14 and and CC work_fzrpauvhvnexhintldqhzusndm 174 15 dimensionality dimensionality NN work_fzrpauvhvnexhintldqhzusndm 174 16 , , , work_fzrpauvhvnexhintldqhzusndm 174 17 which which WDT work_fzrpauvhvnexhintldqhzusndm 174 18 represent represent VBP work_fzrpauvhvnexhintldqhzusndm 174 19 one one CD work_fzrpauvhvnexhintldqhzusndm 174 20 of of IN work_fzrpauvhvnexhintldqhzusndm 174 21 the the DT work_fzrpauvhvnexhintldqhzusndm 174 22 major major JJ work_fzrpauvhvnexhintldqhzusndm 174 23 computational computational JJ work_fzrpauvhvnexhintldqhzusndm 174 24 challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 174 25 when when WRB work_fzrpauvhvnexhintldqhzusndm 174 26 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 174 27 comes come VBZ work_fzrpauvhvnexhintldqhzusndm 174 28 to to IN work_fzrpauvhvnexhintldqhzusndm 174 29 data datum NNS work_fzrpauvhvnexhintldqhzusndm 174 30 integration integration NN work_fzrpauvhvnexhintldqhzusndm 174 31 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 174 32 42 42 CD work_fzrpauvhvnexhintldqhzusndm 174 33 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 174 34 . . . work_fzrpauvhvnexhintldqhzusndm 175 1 Advances advance NNS work_fzrpauvhvnexhintldqhzusndm 175 2 in in IN work_fzrpauvhvnexhintldqhzusndm 175 3 the the DT work_fzrpauvhvnexhintldqhzusndm 175 4 field field NN work_fzrpauvhvnexhintldqhzusndm 175 5 of of IN work_fzrpauvhvnexhintldqhzusndm 175 6 data datum NNS work_fzrpauvhvnexhintldqhzusndm 175 7 integration integration NN work_fzrpauvhvnexhintldqhzusndm 175 8 have have VBP work_fzrpauvhvnexhintldqhzusndm 175 9 made make VBN work_fzrpauvhvnexhintldqhzusndm 175 10 it -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 175 11 possible possible JJ work_fzrpauvhvnexhintldqhzusndm 175 12 to to TO work_fzrpauvhvnexhintldqhzusndm 175 13 start start VB work_fzrpauvhvnexhintldqhzusndm 175 14 generating generate VBG work_fzrpauvhvnexhintldqhzusndm 175 15 guidelines guideline NNS work_fzrpauvhvnexhintldqhzusndm 175 16 on on IN work_fzrpauvhvnexhintldqhzusndm 175 17 data datum NNS work_fzrpauvhvnexhintldqhzusndm 175 18 integration integration NN work_fzrpauvhvnexhintldqhzusndm 175 19 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 175 20 depending depend VBG work_fzrpauvhvnexhintldqhzusndm 175 21 on on IN work_fzrpauvhvnexhintldqhzusndm 175 22 the the DT work_fzrpauvhvnexhintldqhzusndm 175 23 size size NN work_fzrpauvhvnexhintldqhzusndm 175 24 of of IN work_fzrpauvhvnexhintldqhzusndm 175 25 the the DT work_fzrpauvhvnexhintldqhzusndm 175 26 dataset dataset NN work_fzrpauvhvnexhintldqhzusndm 175 27 and and CC work_fzrpauvhvnexhintldqhzusndm 175 28 its -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 175 29 heterogeneity heterogeneity NN work_fzrpauvhvnexhintldqhzusndm 175 30 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 175 31 43 43 CD work_fzrpauvhvnexhintldqhzusndm 175 32 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 175 33 . . . work_fzrpauvhvnexhintldqhzusndm 176 1 These these DT work_fzrpauvhvnexhintldqhzusndm 176 2 methods method NNS work_fzrpauvhvnexhintldqhzusndm 176 3 and and CC work_fzrpauvhvnexhintldqhzusndm 176 4 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 176 5 are be VBP work_fzrpauvhvnexhintldqhzusndm 176 6 still still RB work_fzrpauvhvnexhintldqhzusndm 176 7 in in IN work_fzrpauvhvnexhintldqhzusndm 176 8 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 176 9 infancy infancy NN work_fzrpauvhvnexhintldqhzusndm 176 10 and and CC work_fzrpauvhvnexhintldqhzusndm 176 11 , , , work_fzrpauvhvnexhintldqhzusndm 176 12 at at IN work_fzrpauvhvnexhintldqhzusndm 176 13 present present JJ work_fzrpauvhvnexhintldqhzusndm 176 14 , , , work_fzrpauvhvnexhintldqhzusndm 176 15 highly highly RB work_fzrpauvhvnexhintldqhzusndm 176 16 specialized specialized JJ work_fzrpauvhvnexhintldqhzusndm 176 17 , , , work_fzrpauvhvnexhintldqhzusndm 176 18 but but CC work_fzrpauvhvnexhintldqhzusndm 176 19 are be VBP work_fzrpauvhvnexhintldqhzusndm 176 20 anticipated anticipate VBN work_fzrpauvhvnexhintldqhzusndm 176 21 to to TO work_fzrpauvhvnexhintldqhzusndm 176 22 become become VB work_fzrpauvhvnexhintldqhzusndm 176 23 more more RBR work_fzrpauvhvnexhintldqhzusndm 176 24 established established JJ work_fzrpauvhvnexhintldqhzusndm 176 25 as as IN work_fzrpauvhvnexhintldqhzusndm 176 26 more more JJR work_fzrpauvhvnexhintldqhzusndm 176 27 researchers researcher NNS work_fzrpauvhvnexhintldqhzusndm 176 28 enter enter VBP work_fzrpauvhvnexhintldqhzusndm 176 29 the the DT work_fzrpauvhvnexhintldqhzusndm 176 30 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 176 31 space space NN work_fzrpauvhvnexhintldqhzusndm 176 32 . . . work_fzrpauvhvnexhintldqhzusndm 177 1 6 6 CD work_fzrpauvhvnexhintldqhzusndm 177 2 . . . work_fzrpauvhvnexhintldqhzusndm 178 1 Concluding conclude VBG work_fzrpauvhvnexhintldqhzusndm 178 2 Remarks Remarks NNPS work_fzrpauvhvnexhintldqhzusndm 178 3 Post post JJ work_fzrpauvhvnexhintldqhzusndm 178 4 - - JJ work_fzrpauvhvnexhintldqhzusndm 178 5 industrial industrial JJ work_fzrpauvhvnexhintldqhzusndm 178 6 changes change NNS work_fzrpauvhvnexhintldqhzusndm 178 7 to to IN work_fzrpauvhvnexhintldqhzusndm 178 8 the the DT work_fzrpauvhvnexhintldqhzusndm 178 9 environment environment NN work_fzrpauvhvnexhintldqhzusndm 178 10 are be VBP work_fzrpauvhvnexhintldqhzusndm 178 11 associated associate VBN work_fzrpauvhvnexhintldqhzusndm 178 12 with with IN work_fzrpauvhvnexhintldqhzusndm 178 13 rising rise VBG work_fzrpauvhvnexhintldqhzusndm 178 14 rates rate NNS work_fzrpauvhvnexhintldqhzusndm 178 15 of of IN work_fzrpauvhvnexhintldqhzusndm 178 16 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 178 17 non non JJ work_fzrpauvhvnexhintldqhzusndm 178 18 - - JJ work_fzrpauvhvnexhintldqhzusndm 178 19 communicable communicable JJ work_fzrpauvhvnexhintldqhzusndm 178 20 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 178 21 in in IN work_fzrpauvhvnexhintldqhzusndm 178 22 many many JJ work_fzrpauvhvnexhintldqhzusndm 178 23 parts part NNS work_fzrpauvhvnexhintldqhzusndm 178 24 of of IN work_fzrpauvhvnexhintldqhzusndm 178 25 the the DT work_fzrpauvhvnexhintldqhzusndm 178 26 world world NN work_fzrpauvhvnexhintldqhzusndm 178 27 . . . work_fzrpauvhvnexhintldqhzusndm 179 1 Changes change NNS work_fzrpauvhvnexhintldqhzusndm 179 2 in in IN work_fzrpauvhvnexhintldqhzusndm 179 3 the the DT work_fzrpauvhvnexhintldqhzusndm 179 4 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 179 5 and and CC work_fzrpauvhvnexhintldqhzusndm 179 6 the the DT work_fzrpauvhvnexhintldqhzusndm 179 7 effect effect NN work_fzrpauvhvnexhintldqhzusndm 179 8 on on IN work_fzrpauvhvnexhintldqhzusndm 179 9 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 179 10 development development NN work_fzrpauvhvnexhintldqhzusndm 179 11 are be VBP work_fzrpauvhvnexhintldqhzusndm 179 12 firmly firmly RB work_fzrpauvhvnexhintldqhzusndm 179 13 implicated implicate VBN work_fzrpauvhvnexhintldqhzusndm 179 14 , , , work_fzrpauvhvnexhintldqhzusndm 179 15 given give VBN work_fzrpauvhvnexhintldqhzusndm 179 16 the the DT work_fzrpauvhvnexhintldqhzusndm 179 17 development development NN work_fzrpauvhvnexhintldqhzusndm 179 18 of of IN work_fzrpauvhvnexhintldqhzusndm 179 19 the the DT work_fzrpauvhvnexhintldqhzusndm 179 20 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 179 21 in in IN work_fzrpauvhvnexhintldqhzusndm 179 22 early early JJ work_fzrpauvhvnexhintldqhzusndm 179 23 life life NN work_fzrpauvhvnexhintldqhzusndm 179 24 is be VBZ work_fzrpauvhvnexhintldqhzusndm 179 25 particularly particularly RB work_fzrpauvhvnexhintldqhzusndm 179 26 sensitive sensitive JJ work_fzrpauvhvnexhintldqhzusndm 179 27 to to IN work_fzrpauvhvnexhintldqhzusndm 179 28 even even RB work_fzrpauvhvnexhintldqhzusndm 179 29 minor minor JJ work_fzrpauvhvnexhintldqhzusndm 179 30 disturbances disturbance NNS work_fzrpauvhvnexhintldqhzusndm 179 31 . . . work_fzrpauvhvnexhintldqhzusndm 180 1 Given give VBN work_fzrpauvhvnexhintldqhzusndm 180 2 the the DT work_fzrpauvhvnexhintldqhzusndm 180 3 complexity complexity NN work_fzrpauvhvnexhintldqhzusndm 180 4 and and CC work_fzrpauvhvnexhintldqhzusndm 180 5 multifactorial multifactorial JJ work_fzrpauvhvnexhintldqhzusndm 180 6 nature nature NN work_fzrpauvhvnexhintldqhzusndm 180 7 of of IN work_fzrpauvhvnexhintldqhzusndm 180 8 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 180 9 development development NN work_fzrpauvhvnexhintldqhzusndm 180 10 , , , work_fzrpauvhvnexhintldqhzusndm 180 11 systems system NNS work_fzrpauvhvnexhintldqhzusndm 180 12 - - HYPH work_fzrpauvhvnexhintldqhzusndm 180 13 level level NN work_fzrpauvhvnexhintldqhzusndm 180 14 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 180 15 are be VBP work_fzrpauvhvnexhintldqhzusndm 180 16 now now RB work_fzrpauvhvnexhintldqhzusndm 180 17 needed need VBN work_fzrpauvhvnexhintldqhzusndm 180 18 to to TO work_fzrpauvhvnexhintldqhzusndm 180 19 delineate delineate VB work_fzrpauvhvnexhintldqhzusndm 180 20 trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 180 21 of of IN work_fzrpauvhvnexhintldqhzusndm 180 22 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 180 23 ontogeny ontogeny NN work_fzrpauvhvnexhintldqhzusndm 180 24 . . . work_fzrpauvhvnexhintldqhzusndm 181 1 We -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 181 2 posit posit VBP work_fzrpauvhvnexhintldqhzusndm 181 3 , , , work_fzrpauvhvnexhintldqhzusndm 181 4 therefore therefore RB work_fzrpauvhvnexhintldqhzusndm 181 5 , , , work_fzrpauvhvnexhintldqhzusndm 181 6 that that IN work_fzrpauvhvnexhintldqhzusndm 181 7 integrative integrative JJ work_fzrpauvhvnexhintldqhzusndm 181 8 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 181 9 is be VBZ work_fzrpauvhvnexhintldqhzusndm 181 10 expected expect VBN work_fzrpauvhvnexhintldqhzusndm 181 11 to to TO work_fzrpauvhvnexhintldqhzusndm 181 12 become become VB work_fzrpauvhvnexhintldqhzusndm 181 13 increasingly increasingly RB work_fzrpauvhvnexhintldqhzusndm 181 14 influential influential JJ work_fzrpauvhvnexhintldqhzusndm 181 15 for for IN work_fzrpauvhvnexhintldqhzusndm 181 16 disease disease NNP work_fzrpauvhvnexhintldqhzusndm 181 17 prediction prediction NN work_fzrpauvhvnexhintldqhzusndm 181 18 , , , work_fzrpauvhvnexhintldqhzusndm 181 19 diagnosis diagnosis NN work_fzrpauvhvnexhintldqhzusndm 181 20 , , , work_fzrpauvhvnexhintldqhzusndm 181 21 prevention prevention NN work_fzrpauvhvnexhintldqhzusndm 181 22 , , , work_fzrpauvhvnexhintldqhzusndm 181 23 and and CC work_fzrpauvhvnexhintldqhzusndm 181 24 prognosis prognosis NN work_fzrpauvhvnexhintldqhzusndm 181 25 . . . work_fzrpauvhvnexhintldqhzusndm 182 1 While while IN work_fzrpauvhvnexhintldqhzusndm 182 2 these these DT work_fzrpauvhvnexhintldqhzusndm 182 3 approaches approach NNS work_fzrpauvhvnexhintldqhzusndm 182 4 are be VBP work_fzrpauvhvnexhintldqhzusndm 182 5 still still RB work_fzrpauvhvnexhintldqhzusndm 182 6 in in IN work_fzrpauvhvnexhintldqhzusndm 182 7 their -PRON- PRP$ work_fzrpauvhvnexhintldqhzusndm 182 8 infancy infancy NN work_fzrpauvhvnexhintldqhzusndm 182 9 , , , work_fzrpauvhvnexhintldqhzusndm 182 10 the the DT work_fzrpauvhvnexhintldqhzusndm 182 11 future future JJ work_fzrpauvhvnexhintldqhzusndm 182 12 development development NN work_fzrpauvhvnexhintldqhzusndm 182 13 of of IN work_fzrpauvhvnexhintldqhzusndm 182 14 multiomic multiomic NN work_fzrpauvhvnexhintldqhzusndm 182 15 workflows workflow NNS work_fzrpauvhvnexhintldqhzusndm 182 16 and and CC work_fzrpauvhvnexhintldqhzusndm 182 17 community community NN work_fzrpauvhvnexhintldqhzusndm 182 18 standards standard NNS work_fzrpauvhvnexhintldqhzusndm 182 19 will will MD work_fzrpauvhvnexhintldqhzusndm 182 20 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 182 21 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 182 22 , , , work_fzrpauvhvnexhintldqhzusndm 182 23 10 10 CD work_fzrpauvhvnexhintldqhzusndm 182 24 , , , work_fzrpauvhvnexhintldqhzusndm 182 25 23 23 CD work_fzrpauvhvnexhintldqhzusndm 182 26 7 7 CD work_fzrpauvhvnexhintldqhzusndm 182 27 of of IN work_fzrpauvhvnexhintldqhzusndm 182 28 9 9 CD work_fzrpauvhvnexhintldqhzusndm 182 29 be be VB work_fzrpauvhvnexhintldqhzusndm 182 30 necessary necessary JJ work_fzrpauvhvnexhintldqhzusndm 182 31 milestones milestone NNS work_fzrpauvhvnexhintldqhzusndm 182 32 toward toward IN work_fzrpauvhvnexhintldqhzusndm 182 33 capitalizing capitalize VBG work_fzrpauvhvnexhintldqhzusndm 182 34 on on IN work_fzrpauvhvnexhintldqhzusndm 182 35 the the DT work_fzrpauvhvnexhintldqhzusndm 182 36 potential potential JJ work_fzrpauvhvnexhintldqhzusndm 182 37 benefits benefit NNS work_fzrpauvhvnexhintldqhzusndm 182 38 of of IN work_fzrpauvhvnexhintldqhzusndm 182 39 multilevel multilevel JJ work_fzrpauvhvnexhintldqhzusndm 182 40 data datum NNS work_fzrpauvhvnexhintldqhzusndm 182 41 integration integration NN work_fzrpauvhvnexhintldqhzusndm 182 42 . . . work_fzrpauvhvnexhintldqhzusndm 183 1 At at IN work_fzrpauvhvnexhintldqhzusndm 183 2 present present NN work_fzrpauvhvnexhintldqhzusndm 183 3 , , , work_fzrpauvhvnexhintldqhzusndm 183 4 the the DT work_fzrpauvhvnexhintldqhzusndm 183 5 only only JJ work_fzrpauvhvnexhintldqhzusndm 183 6 cases case NNS work_fzrpauvhvnexhintldqhzusndm 183 7 of of IN work_fzrpauvhvnexhintldqhzusndm 183 8 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 183 9 technologies technology NNS work_fzrpauvhvnexhintldqhzusndm 183 10 that that WDT work_fzrpauvhvnexhintldqhzusndm 183 11 have have VBP work_fzrpauvhvnexhintldqhzusndm 183 12 translated translate VBN work_fzrpauvhvnexhintldqhzusndm 183 13 to to IN work_fzrpauvhvnexhintldqhzusndm 183 14 the the DT work_fzrpauvhvnexhintldqhzusndm 183 15 clinic clinic NN work_fzrpauvhvnexhintldqhzusndm 183 16 include include VBP work_fzrpauvhvnexhintldqhzusndm 183 17 genome genome JJ work_fzrpauvhvnexhintldqhzusndm 183 18 sequencing sequencing NN work_fzrpauvhvnexhintldqhzusndm 183 19 and and CC work_fzrpauvhvnexhintldqhzusndm 183 20 , , , work_fzrpauvhvnexhintldqhzusndm 183 21 to to IN work_fzrpauvhvnexhintldqhzusndm 183 22 a a DT work_fzrpauvhvnexhintldqhzusndm 183 23 lesser less JJR work_fzrpauvhvnexhintldqhzusndm 183 24 extent extent NN work_fzrpauvhvnexhintldqhzusndm 183 25 , , , work_fzrpauvhvnexhintldqhzusndm 183 26 RNA RNA NNP work_fzrpauvhvnexhintldqhzusndm 183 27 sequencing sequence VBG work_fzrpauvhvnexhintldqhzusndm 183 28 . . . work_fzrpauvhvnexhintldqhzusndm 184 1 Substantial substantial JJ work_fzrpauvhvnexhintldqhzusndm 184 2 regulatory regulatory JJ work_fzrpauvhvnexhintldqhzusndm 184 3 and and CC work_fzrpauvhvnexhintldqhzusndm 184 4 technical technical JJ work_fzrpauvhvnexhintldqhzusndm 184 5 hurdles hurdle NNS work_fzrpauvhvnexhintldqhzusndm 184 6 exist exist VBP work_fzrpauvhvnexhintldqhzusndm 184 7 before before IN work_fzrpauvhvnexhintldqhzusndm 184 8 other other JJ work_fzrpauvhvnexhintldqhzusndm 184 9 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 184 10 techniques technique NNS work_fzrpauvhvnexhintldqhzusndm 184 11 will will MD work_fzrpauvhvnexhintldqhzusndm 184 12 be be VB work_fzrpauvhvnexhintldqhzusndm 184 13 approved approve VBN work_fzrpauvhvnexhintldqhzusndm 184 14 for for IN work_fzrpauvhvnexhintldqhzusndm 184 15 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 184 16 use use NN work_fzrpauvhvnexhintldqhzusndm 184 17 . . . work_fzrpauvhvnexhintldqhzusndm 185 1 Therefore therefore RB work_fzrpauvhvnexhintldqhzusndm 185 2 , , , work_fzrpauvhvnexhintldqhzusndm 185 3 in in IN work_fzrpauvhvnexhintldqhzusndm 185 4 the the DT work_fzrpauvhvnexhintldqhzusndm 185 5 short short NN work_fzrpauvhvnexhintldqhzusndm 185 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 185 7 to to IN work_fzrpauvhvnexhintldqhzusndm 185 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 185 9 medium medium NN work_fzrpauvhvnexhintldqhzusndm 185 10 term term NN work_fzrpauvhvnexhintldqhzusndm 185 11 , , , work_fzrpauvhvnexhintldqhzusndm 185 12 we -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 185 13 anticipate anticipate VBP work_fzrpauvhvnexhintldqhzusndm 185 14 integrative integrative JJ work_fzrpauvhvnexhintldqhzusndm 185 15 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 185 16 and and CC work_fzrpauvhvnexhintldqhzusndm 185 17 associated associate VBN work_fzrpauvhvnexhintldqhzusndm 185 18 models model NNS work_fzrpauvhvnexhintldqhzusndm 185 19 of of IN work_fzrpauvhvnexhintldqhzusndm 185 20 disease disease NN work_fzrpauvhvnexhintldqhzusndm 185 21 risk risk NN work_fzrpauvhvnexhintldqhzusndm 185 22 will will MD work_fzrpauvhvnexhintldqhzusndm 185 23 enhance enhance VB work_fzrpauvhvnexhintldqhzusndm 185 24 the the DT work_fzrpauvhvnexhintldqhzusndm 185 25 research research NN work_fzrpauvhvnexhintldqhzusndm 185 26 enterprise enterprise NN work_fzrpauvhvnexhintldqhzusndm 185 27 and and CC work_fzrpauvhvnexhintldqhzusndm 185 28 enable enable VB work_fzrpauvhvnexhintldqhzusndm 185 29 a a DT work_fzrpauvhvnexhintldqhzusndm 185 30 clearer clear JJR work_fzrpauvhvnexhintldqhzusndm 185 31 picture picture NN work_fzrpauvhvnexhintldqhzusndm 185 32 of of IN work_fzrpauvhvnexhintldqhzusndm 185 33 health health NN work_fzrpauvhvnexhintldqhzusndm 185 34 and and CC work_fzrpauvhvnexhintldqhzusndm 185 35 disease disease NN work_fzrpauvhvnexhintldqhzusndm 185 36 . . . work_fzrpauvhvnexhintldqhzusndm 186 1 The the DT work_fzrpauvhvnexhintldqhzusndm 186 2 initial initial JJ work_fzrpauvhvnexhintldqhzusndm 186 3 stages stage NNS work_fzrpauvhvnexhintldqhzusndm 186 4 toward toward IN work_fzrpauvhvnexhintldqhzusndm 186 5 uptake uptake NN work_fzrpauvhvnexhintldqhzusndm 186 6 will will MD work_fzrpauvhvnexhintldqhzusndm 186 7 need need VB work_fzrpauvhvnexhintldqhzusndm 186 8 to to TO work_fzrpauvhvnexhintldqhzusndm 186 9 initially initially RB work_fzrpauvhvnexhintldqhzusndm 186 10 demonstrate demonstrate VB work_fzrpauvhvnexhintldqhzusndm 186 11 novel novel JJ work_fzrpauvhvnexhintldqhzusndm 186 12 actionable actionable JJ work_fzrpauvhvnexhintldqhzusndm 186 13 insights insight NNS work_fzrpauvhvnexhintldqhzusndm 186 14 and and CC work_fzrpauvhvnexhintldqhzusndm 186 15 then then RB work_fzrpauvhvnexhintldqhzusndm 186 16 prove prove VB work_fzrpauvhvnexhintldqhzusndm 186 17 through through IN work_fzrpauvhvnexhintldqhzusndm 186 18 rigorous rigorous JJ work_fzrpauvhvnexhintldqhzusndm 186 19 trial trial NN work_fzrpauvhvnexhintldqhzusndm 186 20 - - HYPH work_fzrpauvhvnexhintldqhzusndm 186 21 based base VBN work_fzrpauvhvnexhintldqhzusndm 186 22 testing testing NN work_fzrpauvhvnexhintldqhzusndm 186 23 that that WDT work_fzrpauvhvnexhintldqhzusndm 186 24 early early JJ work_fzrpauvhvnexhintldqhzusndm 186 25 interventions intervention NNS work_fzrpauvhvnexhintldqhzusndm 186 26 designed design VBN work_fzrpauvhvnexhintldqhzusndm 186 27 from from IN work_fzrpauvhvnexhintldqhzusndm 186 28 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 186 29 data datum NNS work_fzrpauvhvnexhintldqhzusndm 186 30 do do VBP work_fzrpauvhvnexhintldqhzusndm 186 31 indeed indeed RB work_fzrpauvhvnexhintldqhzusndm 186 32 provide provide VB work_fzrpauvhvnexhintldqhzusndm 186 33 tangible tangible JJ work_fzrpauvhvnexhintldqhzusndm 186 34 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 186 35 benefits benefit NNS work_fzrpauvhvnexhintldqhzusndm 186 36 . . . work_fzrpauvhvnexhintldqhzusndm 187 1 In in IN work_fzrpauvhvnexhintldqhzusndm 187 2 parallel parallel NN work_fzrpauvhvnexhintldqhzusndm 187 3 , , , work_fzrpauvhvnexhintldqhzusndm 187 4 the the DT work_fzrpauvhvnexhintldqhzusndm 187 5 data data NN work_fzrpauvhvnexhintldqhzusndm 187 6 standards standard NNS work_fzrpauvhvnexhintldqhzusndm 187 7 and and CC work_fzrpauvhvnexhintldqhzusndm 187 8 precision precision NN work_fzrpauvhvnexhintldqhzusndm 187 9 around around IN work_fzrpauvhvnexhintldqhzusndm 187 10 individual individual JJ work_fzrpauvhvnexhintldqhzusndm 187 11 omic omic JJ work_fzrpauvhvnexhintldqhzusndm 187 12 platforms platform NNS work_fzrpauvhvnexhintldqhzusndm 187 13 will will MD work_fzrpauvhvnexhintldqhzusndm 187 14 need need VB work_fzrpauvhvnexhintldqhzusndm 187 15 to to TO work_fzrpauvhvnexhintldqhzusndm 187 16 comply comply VB work_fzrpauvhvnexhintldqhzusndm 187 17 with with IN work_fzrpauvhvnexhintldqhzusndm 187 18 levels level NNS work_fzrpauvhvnexhintldqhzusndm 187 19 acceptable acceptable JJ work_fzrpauvhvnexhintldqhzusndm 187 20 for for IN work_fzrpauvhvnexhintldqhzusndm 187 21 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 187 22 tests test NNS work_fzrpauvhvnexhintldqhzusndm 187 23 in in IN work_fzrpauvhvnexhintldqhzusndm 187 24 order order NN work_fzrpauvhvnexhintldqhzusndm 187 25 to to TO work_fzrpauvhvnexhintldqhzusndm 187 26 transition transition VB work_fzrpauvhvnexhintldqhzusndm 187 27 into into IN work_fzrpauvhvnexhintldqhzusndm 187 28 the the DT work_fzrpauvhvnexhintldqhzusndm 187 29 healthcare healthcare NN work_fzrpauvhvnexhintldqhzusndm 187 30 setting setting NN work_fzrpauvhvnexhintldqhzusndm 187 31 . . . work_fzrpauvhvnexhintldqhzusndm 188 1 Although although IN work_fzrpauvhvnexhintldqhzusndm 188 2 the the DT work_fzrpauvhvnexhintldqhzusndm 188 3 challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 188 4 are be VBP work_fzrpauvhvnexhintldqhzusndm 188 5 substantial substantial JJ work_fzrpauvhvnexhintldqhzusndm 188 6 , , , work_fzrpauvhvnexhintldqhzusndm 188 7 the the DT work_fzrpauvhvnexhintldqhzusndm 188 8 potential potential JJ work_fzrpauvhvnexhintldqhzusndm 188 9 benefits benefit NNS work_fzrpauvhvnexhintldqhzusndm 188 10 of of IN work_fzrpauvhvnexhintldqhzusndm 188 11 multiomic multiomic JJ work_fzrpauvhvnexhintldqhzusndm 188 12 studies study NNS work_fzrpauvhvnexhintldqhzusndm 188 13 necessitate necessitate NNP work_fzrpauvhvnexhintldqhzusndm 188 14 research research NN work_fzrpauvhvnexhintldqhzusndm 188 15 and and CC work_fzrpauvhvnexhintldqhzusndm 188 16 development development NN work_fzrpauvhvnexhintldqhzusndm 188 17 . . . work_fzrpauvhvnexhintldqhzusndm 189 1 Author author NN work_fzrpauvhvnexhintldqhzusndm 189 2 Contributions contribution NNS work_fzrpauvhvnexhintldqhzusndm 189 3 : : : work_fzrpauvhvnexhintldqhzusndm 189 4 Writing writing NN work_fzrpauvhvnexhintldqhzusndm 189 5 — — : work_fzrpauvhvnexhintldqhzusndm 189 6 Original Original NNP work_fzrpauvhvnexhintldqhzusndm 189 7 Draft Draft NNP work_fzrpauvhvnexhintldqhzusndm 189 8 Preparation Preparation NNP work_fzrpauvhvnexhintldqhzusndm 189 9 , , , work_fzrpauvhvnexhintldqhzusndm 189 10 D.M. D.M. NNP work_fzrpauvhvnexhintldqhzusndm 189 11 , , , work_fzrpauvhvnexhintldqhzusndm 189 12 R.B.O. R.B.O. NNP work_fzrpauvhvnexhintldqhzusndm 189 13 , , , work_fzrpauvhvnexhintldqhzusndm 189 14 D.H. D.H. NNP work_fzrpauvhvnexhintldqhzusndm 189 15 , , , work_fzrpauvhvnexhintldqhzusndm 189 16 A.B. A.B. NNP work_fzrpauvhvnexhintldqhzusndm 190 1 Writing writing NN work_fzrpauvhvnexhintldqhzusndm 190 2 — — : work_fzrpauvhvnexhintldqhzusndm 190 3 Review Review NNP work_fzrpauvhvnexhintldqhzusndm 190 4 & & CC work_fzrpauvhvnexhintldqhzusndm 190 5 Editing Editing NNP work_fzrpauvhvnexhintldqhzusndm 190 6 , , , work_fzrpauvhvnexhintldqhzusndm 190 7 D.M. D.M. NNP work_fzrpauvhvnexhintldqhzusndm 190 8 , , , work_fzrpauvhvnexhintldqhzusndm 190 9 R.B.O. R.B.O. NNP work_fzrpauvhvnexhintldqhzusndm 190 10 , , , work_fzrpauvhvnexhintldqhzusndm 190 11 D.H. D.H. NNP work_fzrpauvhvnexhintldqhzusndm 190 12 , , , work_fzrpauvhvnexhintldqhzusndm 190 13 A.B. A.B. NNP work_fzrpauvhvnexhintldqhzusndm 191 1 Funding funding NN work_fzrpauvhvnexhintldqhzusndm 191 2 : : : work_fzrpauvhvnexhintldqhzusndm 191 3 This this DT work_fzrpauvhvnexhintldqhzusndm 191 4 research research NN work_fzrpauvhvnexhintldqhzusndm 191 5 received receive VBD work_fzrpauvhvnexhintldqhzusndm 191 6 no no DT work_fzrpauvhvnexhintldqhzusndm 191 7 external external JJ work_fzrpauvhvnexhintldqhzusndm 191 8 funding funding NN work_fzrpauvhvnexhintldqhzusndm 191 9 . . . work_fzrpauvhvnexhintldqhzusndm 192 1 Conflicts conflict NNS work_fzrpauvhvnexhintldqhzusndm 192 2 of of IN work_fzrpauvhvnexhintldqhzusndm 192 3 Interest interest NN work_fzrpauvhvnexhintldqhzusndm 192 4 : : : work_fzrpauvhvnexhintldqhzusndm 192 5 The the DT work_fzrpauvhvnexhintldqhzusndm 192 6 authors author NNS work_fzrpauvhvnexhintldqhzusndm 192 7 declare declare VBP work_fzrpauvhvnexhintldqhzusndm 192 8 no no DT work_fzrpauvhvnexhintldqhzusndm 192 9 conflict conflict NN work_fzrpauvhvnexhintldqhzusndm 192 10 of of IN work_fzrpauvhvnexhintldqhzusndm 192 11 interest interest NN work_fzrpauvhvnexhintldqhzusndm 192 12 . . . work_fzrpauvhvnexhintldqhzusndm 193 1 References reference NNS work_fzrpauvhvnexhintldqhzusndm 193 2 1 1 CD work_fzrpauvhvnexhintldqhzusndm 193 3 . . . work_fzrpauvhvnexhintldqhzusndm 194 1 Renz Renz NNP work_fzrpauvhvnexhintldqhzusndm 194 2 , , , work_fzrpauvhvnexhintldqhzusndm 194 3 H. H. NNP work_fzrpauvhvnexhintldqhzusndm 194 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 194 5 Holt Holt NNP work_fzrpauvhvnexhintldqhzusndm 194 6 , , , work_fzrpauvhvnexhintldqhzusndm 194 7 P.G. P.G. NNP work_fzrpauvhvnexhintldqhzusndm 195 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 195 2 Inouye Inouye NNP work_fzrpauvhvnexhintldqhzusndm 195 3 , , , work_fzrpauvhvnexhintldqhzusndm 195 4 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 195 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 195 6 Logan Logan NNP work_fzrpauvhvnexhintldqhzusndm 195 7 , , , work_fzrpauvhvnexhintldqhzusndm 195 8 A.C. A.C. NNP work_fzrpauvhvnexhintldqhzusndm 195 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 195 10 Prescott Prescott NNP work_fzrpauvhvnexhintldqhzusndm 195 11 , , , work_fzrpauvhvnexhintldqhzusndm 195 12 S.L. S.L. NNP work_fzrpauvhvnexhintldqhzusndm 196 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 196 2 Sly Sly NNP work_fzrpauvhvnexhintldqhzusndm 196 3 , , , work_fzrpauvhvnexhintldqhzusndm 196 4 P.D. P.D. NNP work_fzrpauvhvnexhintldqhzusndm 197 1 An an DT work_fzrpauvhvnexhintldqhzusndm 197 2 exposome exposome JJ work_fzrpauvhvnexhintldqhzusndm 197 3 perspective perspective NN work_fzrpauvhvnexhintldqhzusndm 197 4 : : : work_fzrpauvhvnexhintldqhzusndm 197 5 Early early JJ work_fzrpauvhvnexhintldqhzusndm 197 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 197 7 life life NN work_fzrpauvhvnexhintldqhzusndm 197 8 events event NNS work_fzrpauvhvnexhintldqhzusndm 197 9 and and CC work_fzrpauvhvnexhintldqhzusndm 197 10 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 197 11 development development NN work_fzrpauvhvnexhintldqhzusndm 197 12 in in IN work_fzrpauvhvnexhintldqhzusndm 197 13 a a DT work_fzrpauvhvnexhintldqhzusndm 197 14 changing change VBG work_fzrpauvhvnexhintldqhzusndm 197 15 world world NN work_fzrpauvhvnexhintldqhzusndm 197 16 . . . work_fzrpauvhvnexhintldqhzusndm 198 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 199 1 Allergy Allergy NNP work_fzrpauvhvnexhintldqhzusndm 199 2 Clin Clin NNP work_fzrpauvhvnexhintldqhzusndm 199 3 . . . work_fzrpauvhvnexhintldqhzusndm 200 1 Immunol immunol NN work_fzrpauvhvnexhintldqhzusndm 200 2 . . . work_fzrpauvhvnexhintldqhzusndm 201 1 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 201 2 , , , work_fzrpauvhvnexhintldqhzusndm 201 3 140 140 CD work_fzrpauvhvnexhintldqhzusndm 201 4 , , , work_fzrpauvhvnexhintldqhzusndm 201 5 24–40 24–40 CD work_fzrpauvhvnexhintldqhzusndm 201 6 . . . work_fzrpauvhvnexhintldqhzusndm 202 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 202 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 202 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 202 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 202 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 202 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 202 7 2 2 CD work_fzrpauvhvnexhintldqhzusndm 202 8 . . . work_fzrpauvhvnexhintldqhzusndm 203 1 Corbett Corbett NNP work_fzrpauvhvnexhintldqhzusndm 203 2 , , , work_fzrpauvhvnexhintldqhzusndm 203 3 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 203 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 203 5 Courtiol Courtiol NNP work_fzrpauvhvnexhintldqhzusndm 203 6 , , , work_fzrpauvhvnexhintldqhzusndm 203 7 A. a. NN work_fzrpauvhvnexhintldqhzusndm 203 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 203 9 Lummaa Lummaa NNP work_fzrpauvhvnexhintldqhzusndm 203 10 , , , work_fzrpauvhvnexhintldqhzusndm 203 11 V. V. NNP work_fzrpauvhvnexhintldqhzusndm 203 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 203 13 Moorad Moorad NNP work_fzrpauvhvnexhintldqhzusndm 203 14 , , , work_fzrpauvhvnexhintldqhzusndm 203 15 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 203 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 203 17 Stearns Stearns NNP work_fzrpauvhvnexhintldqhzusndm 203 18 , , , work_fzrpauvhvnexhintldqhzusndm 203 19 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 203 20 The the DT work_fzrpauvhvnexhintldqhzusndm 203 21 transition transition NN work_fzrpauvhvnexhintldqhzusndm 203 22 to to IN work_fzrpauvhvnexhintldqhzusndm 203 23 modernity modernity NN work_fzrpauvhvnexhintldqhzusndm 203 24 and and CC work_fzrpauvhvnexhintldqhzusndm 203 25 chronic chronic JJ work_fzrpauvhvnexhintldqhzusndm 203 26 disease disease NN work_fzrpauvhvnexhintldqhzusndm 203 27 : : : work_fzrpauvhvnexhintldqhzusndm 203 28 Mismatch mismatch NN work_fzrpauvhvnexhintldqhzusndm 203 29 and and CC work_fzrpauvhvnexhintldqhzusndm 203 30 natural natural JJ work_fzrpauvhvnexhintldqhzusndm 203 31 selection selection NN work_fzrpauvhvnexhintldqhzusndm 203 32 . . . work_fzrpauvhvnexhintldqhzusndm 204 1 Nat Nat NNP work_fzrpauvhvnexhintldqhzusndm 204 2 . . . work_fzrpauvhvnexhintldqhzusndm 205 1 Rev. Rev. NNP work_fzrpauvhvnexhintldqhzusndm 206 1 Genet Genet NNP work_fzrpauvhvnexhintldqhzusndm 206 2 . . . work_fzrpauvhvnexhintldqhzusndm 207 1 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 207 2 , , , work_fzrpauvhvnexhintldqhzusndm 207 3 19 19 CD work_fzrpauvhvnexhintldqhzusndm 207 4 , , , work_fzrpauvhvnexhintldqhzusndm 207 5 419–430 419–430 CD work_fzrpauvhvnexhintldqhzusndm 207 6 . . . work_fzrpauvhvnexhintldqhzusndm 208 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 208 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 208 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 208 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 208 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 208 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 208 7 3 3 CD work_fzrpauvhvnexhintldqhzusndm 208 8 . . . work_fzrpauvhvnexhintldqhzusndm 209 1 Naghavi Naghavi NNP work_fzrpauvhvnexhintldqhzusndm 209 2 , , , work_fzrpauvhvnexhintldqhzusndm 209 3 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 209 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 209 5 Abajobir Abajobir NNP work_fzrpauvhvnexhintldqhzusndm 209 6 , , , work_fzrpauvhvnexhintldqhzusndm 209 7 A.A. A.A. NNP work_fzrpauvhvnexhintldqhzusndm 209 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 209 9 Abbafati Abbafati NNP work_fzrpauvhvnexhintldqhzusndm 209 10 , , , work_fzrpauvhvnexhintldqhzusndm 209 11 C. C. NNP work_fzrpauvhvnexhintldqhzusndm 209 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 209 13 Abbas Abbas NNP work_fzrpauvhvnexhintldqhzusndm 209 14 , , , work_fzrpauvhvnexhintldqhzusndm 209 15 K.M. K.M. NNP work_fzrpauvhvnexhintldqhzusndm 210 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 210 2 Abd Abd NNP work_fzrpauvhvnexhintldqhzusndm 210 3 - - HYPH work_fzrpauvhvnexhintldqhzusndm 210 4 Allah Allah NNP work_fzrpauvhvnexhintldqhzusndm 210 5 , , , work_fzrpauvhvnexhintldqhzusndm 210 6 F. F. NNP work_fzrpauvhvnexhintldqhzusndm 210 7 ; ; : work_fzrpauvhvnexhintldqhzusndm 210 8 Abera Abera NNP work_fzrpauvhvnexhintldqhzusndm 210 9 , , , work_fzrpauvhvnexhintldqhzusndm 210 10 S.F. S.F. NNP work_fzrpauvhvnexhintldqhzusndm 211 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 211 2 Aboyans Aboyans NNPS work_fzrpauvhvnexhintldqhzusndm 211 3 , , , work_fzrpauvhvnexhintldqhzusndm 211 4 V. V. NNP work_fzrpauvhvnexhintldqhzusndm 211 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 211 6 Adetokunboh Adetokunboh NNP work_fzrpauvhvnexhintldqhzusndm 211 7 , , , work_fzrpauvhvnexhintldqhzusndm 211 8 O. O. NNP work_fzrpauvhvnexhintldqhzusndm 211 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 211 10 Afshin Afshin NNP work_fzrpauvhvnexhintldqhzusndm 211 11 , , , work_fzrpauvhvnexhintldqhzusndm 211 12 A. a. NN work_fzrpauvhvnexhintldqhzusndm 211 13 ; ; : work_fzrpauvhvnexhintldqhzusndm 211 14 Agrawal Agrawal NNP work_fzrpauvhvnexhintldqhzusndm 211 15 , , , work_fzrpauvhvnexhintldqhzusndm 211 16 A. a. NN work_fzrpauvhvnexhintldqhzusndm 211 17 ; ; : work_fzrpauvhvnexhintldqhzusndm 211 18 et et NNP work_fzrpauvhvnexhintldqhzusndm 211 19 al al NNP work_fzrpauvhvnexhintldqhzusndm 211 20 . . . work_fzrpauvhvnexhintldqhzusndm 212 1 Global global JJ work_fzrpauvhvnexhintldqhzusndm 212 2 , , , work_fzrpauvhvnexhintldqhzusndm 212 3 regional regional JJ work_fzrpauvhvnexhintldqhzusndm 212 4 , , , work_fzrpauvhvnexhintldqhzusndm 212 5 and and CC work_fzrpauvhvnexhintldqhzusndm 212 6 national national JJ work_fzrpauvhvnexhintldqhzusndm 212 7 age age NN work_fzrpauvhvnexhintldqhzusndm 212 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 212 9 sex sex NN work_fzrpauvhvnexhintldqhzusndm 212 10 specific specific JJ work_fzrpauvhvnexhintldqhzusndm 212 11 mortality mortality NN work_fzrpauvhvnexhintldqhzusndm 212 12 for for IN work_fzrpauvhvnexhintldqhzusndm 212 13 264 264 CD work_fzrpauvhvnexhintldqhzusndm 212 14 causes cause NNS work_fzrpauvhvnexhintldqhzusndm 212 15 of of IN work_fzrpauvhvnexhintldqhzusndm 212 16 death death NN work_fzrpauvhvnexhintldqhzusndm 212 17 , , , work_fzrpauvhvnexhintldqhzusndm 212 18 1980–2016 1980–2016 CD work_fzrpauvhvnexhintldqhzusndm 212 19 : : : work_fzrpauvhvnexhintldqhzusndm 212 20 A a DT work_fzrpauvhvnexhintldqhzusndm 212 21 systematic systematic JJ work_fzrpauvhvnexhintldqhzusndm 212 22 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 212 23 for for IN work_fzrpauvhvnexhintldqhzusndm 212 24 the the DT work_fzrpauvhvnexhintldqhzusndm 212 25 Global Global NNP work_fzrpauvhvnexhintldqhzusndm 212 26 Burden Burden NNP work_fzrpauvhvnexhintldqhzusndm 212 27 of of IN work_fzrpauvhvnexhintldqhzusndm 212 28 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 212 29 Study Study NNP work_fzrpauvhvnexhintldqhzusndm 212 30 2016 2016 CD work_fzrpauvhvnexhintldqhzusndm 212 31 . . . work_fzrpauvhvnexhintldqhzusndm 213 1 Lancet Lancet NNP work_fzrpauvhvnexhintldqhzusndm 213 2 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 213 3 , , , work_fzrpauvhvnexhintldqhzusndm 213 4 390 390 CD work_fzrpauvhvnexhintldqhzusndm 213 5 , , , work_fzrpauvhvnexhintldqhzusndm 213 6 1151–1210 1151–1210 CD work_fzrpauvhvnexhintldqhzusndm 213 7 . . . work_fzrpauvhvnexhintldqhzusndm 214 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 214 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 214 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 214 4 4 4 CD work_fzrpauvhvnexhintldqhzusndm 214 5 . . . work_fzrpauvhvnexhintldqhzusndm 215 1 Bilbo Bilbo NNP work_fzrpauvhvnexhintldqhzusndm 215 2 , , , work_fzrpauvhvnexhintldqhzusndm 215 3 S.D. S.D. NNP work_fzrpauvhvnexhintldqhzusndm 216 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 216 2 Schwarz Schwarz NNP work_fzrpauvhvnexhintldqhzusndm 216 3 , , , work_fzrpauvhvnexhintldqhzusndm 216 4 J.M. J.M. NNP work_fzrpauvhvnexhintldqhzusndm 217 1 The the DT work_fzrpauvhvnexhintldqhzusndm 217 2 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 217 3 system system NN work_fzrpauvhvnexhintldqhzusndm 217 4 and and CC work_fzrpauvhvnexhintldqhzusndm 217 5 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 217 6 programming programming NN work_fzrpauvhvnexhintldqhzusndm 217 7 of of IN work_fzrpauvhvnexhintldqhzusndm 217 8 brain brain NN work_fzrpauvhvnexhintldqhzusndm 217 9 and and CC work_fzrpauvhvnexhintldqhzusndm 217 10 behavior behavior NN work_fzrpauvhvnexhintldqhzusndm 217 11 . . . work_fzrpauvhvnexhintldqhzusndm 218 1 Front front NN work_fzrpauvhvnexhintldqhzusndm 218 2 . . . work_fzrpauvhvnexhintldqhzusndm 219 1 Neuroendocrinol Neuroendocrinol NNP work_fzrpauvhvnexhintldqhzusndm 219 2 . . . work_fzrpauvhvnexhintldqhzusndm 220 1 2012 2012 CD work_fzrpauvhvnexhintldqhzusndm 220 2 , , , work_fzrpauvhvnexhintldqhzusndm 220 3 33 33 CD work_fzrpauvhvnexhintldqhzusndm 220 4 , , , work_fzrpauvhvnexhintldqhzusndm 220 5 267–286 267–286 CD work_fzrpauvhvnexhintldqhzusndm 220 6 . . . work_fzrpauvhvnexhintldqhzusndm 221 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 221 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 221 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 221 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 221 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 221 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 221 7 5 5 CD work_fzrpauvhvnexhintldqhzusndm 221 8 . . . work_fzrpauvhvnexhintldqhzusndm 222 1 Li Li NNP work_fzrpauvhvnexhintldqhzusndm 222 2 , , , work_fzrpauvhvnexhintldqhzusndm 222 3 C.-X. c.-x. XX work_fzrpauvhvnexhintldqhzusndm 223 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 223 2 Wheelock Wheelock NNP work_fzrpauvhvnexhintldqhzusndm 223 3 , , , work_fzrpauvhvnexhintldqhzusndm 223 4 C.E. C.E. NNP work_fzrpauvhvnexhintldqhzusndm 224 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 224 2 Sköld Sköld NNP work_fzrpauvhvnexhintldqhzusndm 224 3 , , , work_fzrpauvhvnexhintldqhzusndm 224 4 C.M. C.M. NNP work_fzrpauvhvnexhintldqhzusndm 225 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 225 2 Wheelock Wheelock NNP work_fzrpauvhvnexhintldqhzusndm 225 3 , , , work_fzrpauvhvnexhintldqhzusndm 225 4 Å.M. Å.M. NNP work_fzrpauvhvnexhintldqhzusndm 226 1 Integration integration NN work_fzrpauvhvnexhintldqhzusndm 226 2 of of IN work_fzrpauvhvnexhintldqhzusndm 226 3 multi multi JJ work_fzrpauvhvnexhintldqhzusndm 226 4 - - JJ work_fzrpauvhvnexhintldqhzusndm 226 5 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 226 6 datasets dataset NNS work_fzrpauvhvnexhintldqhzusndm 226 7 enables enable VBZ work_fzrpauvhvnexhintldqhzusndm 226 8 molecular molecular JJ work_fzrpauvhvnexhintldqhzusndm 226 9 classification classification NN work_fzrpauvhvnexhintldqhzusndm 226 10 of of IN work_fzrpauvhvnexhintldqhzusndm 226 11 COPD COPD NNS work_fzrpauvhvnexhintldqhzusndm 226 12 . . . work_fzrpauvhvnexhintldqhzusndm 227 1 Eur Eur NNP work_fzrpauvhvnexhintldqhzusndm 227 2 . . . work_fzrpauvhvnexhintldqhzusndm 228 1 Respir Respir NNP work_fzrpauvhvnexhintldqhzusndm 228 2 . . . work_fzrpauvhvnexhintldqhzusndm 229 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 230 1 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 230 2 , , , work_fzrpauvhvnexhintldqhzusndm 230 3 51 51 CD work_fzrpauvhvnexhintldqhzusndm 230 4 , , , work_fzrpauvhvnexhintldqhzusndm 230 5 1701930 1701930 CD work_fzrpauvhvnexhintldqhzusndm 230 6 . . . work_fzrpauvhvnexhintldqhzusndm 231 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 231 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 231 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 231 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 231 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 231 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 231 7 6 6 CD work_fzrpauvhvnexhintldqhzusndm 231 8 . . . work_fzrpauvhvnexhintldqhzusndm 232 1 Moore Moore NNP work_fzrpauvhvnexhintldqhzusndm 232 2 , , , work_fzrpauvhvnexhintldqhzusndm 232 3 T. t. NN work_fzrpauvhvnexhintldqhzusndm 232 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 232 5 Arefadib Arefadib NNP work_fzrpauvhvnexhintldqhzusndm 232 6 , , , work_fzrpauvhvnexhintldqhzusndm 232 7 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 232 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 232 9 Deery Deery NNP work_fzrpauvhvnexhintldqhzusndm 232 10 , , , work_fzrpauvhvnexhintldqhzusndm 232 11 A. a. NN work_fzrpauvhvnexhintldqhzusndm 232 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 232 13 Keyes Keyes NNP work_fzrpauvhvnexhintldqhzusndm 232 14 , , , work_fzrpauvhvnexhintldqhzusndm 232 15 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 232 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 232 17 West West NNP work_fzrpauvhvnexhintldqhzusndm 232 18 , , , work_fzrpauvhvnexhintldqhzusndm 232 19 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 232 20 The the DT work_fzrpauvhvnexhintldqhzusndm 232 21 First First NNP work_fzrpauvhvnexhintldqhzusndm 232 22 Thousand thousand CD work_fzrpauvhvnexhintldqhzusndm 232 23 Days day NNS work_fzrpauvhvnexhintldqhzusndm 232 24 : : : work_fzrpauvhvnexhintldqhzusndm 232 25 An an DT work_fzrpauvhvnexhintldqhzusndm 232 26 Evidence Evidence NNP work_fzrpauvhvnexhintldqhzusndm 232 27 Paper Paper NNP work_fzrpauvhvnexhintldqhzusndm 232 28 ; ; , work_fzrpauvhvnexhintldqhzusndm 232 29 Centre Centre NNP work_fzrpauvhvnexhintldqhzusndm 232 30 for for IN work_fzrpauvhvnexhintldqhzusndm 232 31 Community Community NNP work_fzrpauvhvnexhintldqhzusndm 232 32 Child Child NNP work_fzrpauvhvnexhintldqhzusndm 232 33 Health Health NNP work_fzrpauvhvnexhintldqhzusndm 232 34 , , , work_fzrpauvhvnexhintldqhzusndm 232 35 Murdoch Murdoch NNP work_fzrpauvhvnexhintldqhzusndm 232 36 Children Children NNP work_fzrpauvhvnexhintldqhzusndm 232 37 ’s ’s POS work_fzrpauvhvnexhintldqhzusndm 232 38 Research Research NNP work_fzrpauvhvnexhintldqhzusndm 232 39 Institute Institute NNP work_fzrpauvhvnexhintldqhzusndm 232 40 : : : work_fzrpauvhvnexhintldqhzusndm 232 41 Parkville Parkville NNP work_fzrpauvhvnexhintldqhzusndm 232 42 , , , work_fzrpauvhvnexhintldqhzusndm 232 43 VIC VIC NNP work_fzrpauvhvnexhintldqhzusndm 232 44 , , , work_fzrpauvhvnexhintldqhzusndm 232 45 Australia Australia NNP work_fzrpauvhvnexhintldqhzusndm 232 46 , , , work_fzrpauvhvnexhintldqhzusndm 232 47 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 232 48 . . . work_fzrpauvhvnexhintldqhzusndm 233 1 7 7 LS work_fzrpauvhvnexhintldqhzusndm 233 2 . . . work_fzrpauvhvnexhintldqhzusndm 234 1 Gollwitzer Gollwitzer NNP work_fzrpauvhvnexhintldqhzusndm 234 2 , , , work_fzrpauvhvnexhintldqhzusndm 234 3 E.S. E.S. NNP work_fzrpauvhvnexhintldqhzusndm 235 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 235 2 Marsland Marsland NNP work_fzrpauvhvnexhintldqhzusndm 235 3 , , , work_fzrpauvhvnexhintldqhzusndm 235 4 B.J. B.J. NNP work_fzrpauvhvnexhintldqhzusndm 236 1 Impact impact NN work_fzrpauvhvnexhintldqhzusndm 236 2 of of IN work_fzrpauvhvnexhintldqhzusndm 236 3 Early early JJ work_fzrpauvhvnexhintldqhzusndm 236 4 - - HYPH work_fzrpauvhvnexhintldqhzusndm 236 5 Life life NN work_fzrpauvhvnexhintldqhzusndm 236 6 Exposures exposure NNS work_fzrpauvhvnexhintldqhzusndm 236 7 on on IN work_fzrpauvhvnexhintldqhzusndm 236 8 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 236 9 Maturation Maturation NNP work_fzrpauvhvnexhintldqhzusndm 236 10 and and CC work_fzrpauvhvnexhintldqhzusndm 236 11 Susceptibility Susceptibility NNP work_fzrpauvhvnexhintldqhzusndm 236 12 to to IN work_fzrpauvhvnexhintldqhzusndm 236 13 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 236 14 . . . work_fzrpauvhvnexhintldqhzusndm 237 1 Trends Trends NNPS work_fzrpauvhvnexhintldqhzusndm 237 2 Immunol Immunol NNP work_fzrpauvhvnexhintldqhzusndm 237 3 . . . work_fzrpauvhvnexhintldqhzusndm 238 1 2015 2015 CD work_fzrpauvhvnexhintldqhzusndm 238 2 , , , work_fzrpauvhvnexhintldqhzusndm 238 3 36 36 CD work_fzrpauvhvnexhintldqhzusndm 238 4 , , , work_fzrpauvhvnexhintldqhzusndm 238 5 684–696 684–696 CD work_fzrpauvhvnexhintldqhzusndm 238 6 . . . work_fzrpauvhvnexhintldqhzusndm 239 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 239 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 239 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 239 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 239 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 239 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 239 7 8 8 CD work_fzrpauvhvnexhintldqhzusndm 239 8 . . . work_fzrpauvhvnexhintldqhzusndm 240 1 Olin Olin NNP work_fzrpauvhvnexhintldqhzusndm 240 2 , , , work_fzrpauvhvnexhintldqhzusndm 240 3 A. a. NN work_fzrpauvhvnexhintldqhzusndm 240 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 240 5 Henckel Henckel NNP work_fzrpauvhvnexhintldqhzusndm 240 6 , , , work_fzrpauvhvnexhintldqhzusndm 240 7 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 240 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 240 9 Chen Chen NNP work_fzrpauvhvnexhintldqhzusndm 240 10 , , , work_fzrpauvhvnexhintldqhzusndm 240 11 Y. Y. NNP work_fzrpauvhvnexhintldqhzusndm 240 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 240 13 Lakshmikanth Lakshmikanth NNP work_fzrpauvhvnexhintldqhzusndm 240 14 , , , work_fzrpauvhvnexhintldqhzusndm 240 15 T. T. NNP work_fzrpauvhvnexhintldqhzusndm 240 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 240 17 Pou Pou NNP work_fzrpauvhvnexhintldqhzusndm 240 18 , , , work_fzrpauvhvnexhintldqhzusndm 240 19 C. C. NNP work_fzrpauvhvnexhintldqhzusndm 240 20 ; ; : work_fzrpauvhvnexhintldqhzusndm 240 21 Mikes Mikes NNP work_fzrpauvhvnexhintldqhzusndm 240 22 , , , work_fzrpauvhvnexhintldqhzusndm 240 23 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 240 24 ; ; : work_fzrpauvhvnexhintldqhzusndm 240 25 Gustafsson Gustafsson NNP work_fzrpauvhvnexhintldqhzusndm 240 26 , , , work_fzrpauvhvnexhintldqhzusndm 240 27 A. a. NN work_fzrpauvhvnexhintldqhzusndm 240 28 ; ; : work_fzrpauvhvnexhintldqhzusndm 240 29 Bernhardsson Bernhardsson NNP work_fzrpauvhvnexhintldqhzusndm 240 30 , , , work_fzrpauvhvnexhintldqhzusndm 240 31 A.K. A.K. NNP work_fzrpauvhvnexhintldqhzusndm 241 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 241 2 Zhang Zhang NNP work_fzrpauvhvnexhintldqhzusndm 241 3 , , , work_fzrpauvhvnexhintldqhzusndm 241 4 C. C. NNP work_fzrpauvhvnexhintldqhzusndm 241 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 241 6 Bohlin Bohlin NNP work_fzrpauvhvnexhintldqhzusndm 241 7 , , , work_fzrpauvhvnexhintldqhzusndm 241 8 K. K. NNP work_fzrpauvhvnexhintldqhzusndm 241 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 241 10 et et NNP work_fzrpauvhvnexhintldqhzusndm 241 11 al al NNP work_fzrpauvhvnexhintldqhzusndm 241 12 . . . work_fzrpauvhvnexhintldqhzusndm 242 1 Stereotypic Stereotypic NNP work_fzrpauvhvnexhintldqhzusndm 242 2 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 242 3 System System NNP work_fzrpauvhvnexhintldqhzusndm 242 4 Development Development NNP work_fzrpauvhvnexhintldqhzusndm 242 5 in in IN work_fzrpauvhvnexhintldqhzusndm 242 6 Newborn Newborn NNP work_fzrpauvhvnexhintldqhzusndm 242 7 Children Children NNPS work_fzrpauvhvnexhintldqhzusndm 242 8 . . . work_fzrpauvhvnexhintldqhzusndm 243 1 Cell cell NN work_fzrpauvhvnexhintldqhzusndm 243 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 243 3 , , , work_fzrpauvhvnexhintldqhzusndm 243 4 174 174 CD work_fzrpauvhvnexhintldqhzusndm 243 5 , , , work_fzrpauvhvnexhintldqhzusndm 243 6 1277–1292 1277–1292 CD work_fzrpauvhvnexhintldqhzusndm 243 7 . . . work_fzrpauvhvnexhintldqhzusndm 244 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 244 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 244 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 244 4 9 9 CD work_fzrpauvhvnexhintldqhzusndm 244 5 . . . work_fzrpauvhvnexhintldqhzusndm 245 1 Rothschild Rothschild NNP work_fzrpauvhvnexhintldqhzusndm 245 2 , , , work_fzrpauvhvnexhintldqhzusndm 245 3 D. D. NNP work_fzrpauvhvnexhintldqhzusndm 245 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 245 5 Weissbrod Weissbrod NNP work_fzrpauvhvnexhintldqhzusndm 245 6 , , , work_fzrpauvhvnexhintldqhzusndm 245 7 O. O. NNP work_fzrpauvhvnexhintldqhzusndm 245 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 245 9 Barkan Barkan NNP work_fzrpauvhvnexhintldqhzusndm 245 10 , , , work_fzrpauvhvnexhintldqhzusndm 245 11 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 245 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 245 13 Kurilshikov Kurilshikov NNP work_fzrpauvhvnexhintldqhzusndm 245 14 , , , work_fzrpauvhvnexhintldqhzusndm 245 15 A. a. NN work_fzrpauvhvnexhintldqhzusndm 245 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 245 17 Korem Korem NNP work_fzrpauvhvnexhintldqhzusndm 245 18 , , , work_fzrpauvhvnexhintldqhzusndm 245 19 T. T. NNP work_fzrpauvhvnexhintldqhzusndm 245 20 ; ; : work_fzrpauvhvnexhintldqhzusndm 245 21 Zeevi Zeevi NNP work_fzrpauvhvnexhintldqhzusndm 245 22 , , , work_fzrpauvhvnexhintldqhzusndm 245 23 D. D. NNP work_fzrpauvhvnexhintldqhzusndm 245 24 ; ; : work_fzrpauvhvnexhintldqhzusndm 245 25 Costea Costea NNP work_fzrpauvhvnexhintldqhzusndm 245 26 , , , work_fzrpauvhvnexhintldqhzusndm 245 27 P.I. P.I. NNP work_fzrpauvhvnexhintldqhzusndm 246 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 246 2 Godneva Godneva NNP work_fzrpauvhvnexhintldqhzusndm 246 3 , , , work_fzrpauvhvnexhintldqhzusndm 246 4 A. a. NN work_fzrpauvhvnexhintldqhzusndm 246 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 246 6 Kalka Kalka NNP work_fzrpauvhvnexhintldqhzusndm 246 7 , , , work_fzrpauvhvnexhintldqhzusndm 246 8 I.N. I.N. NNP work_fzrpauvhvnexhintldqhzusndm 247 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 247 2 Bar Bar NNP work_fzrpauvhvnexhintldqhzusndm 247 3 , , , work_fzrpauvhvnexhintldqhzusndm 247 4 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 247 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 247 6 et et NNP work_fzrpauvhvnexhintldqhzusndm 247 7 al al NNP work_fzrpauvhvnexhintldqhzusndm 247 8 . . . work_fzrpauvhvnexhintldqhzusndm 248 1 Environment environment NN work_fzrpauvhvnexhintldqhzusndm 248 2 dominates dominate VBZ work_fzrpauvhvnexhintldqhzusndm 248 3 over over IN work_fzrpauvhvnexhintldqhzusndm 248 4 host host NN work_fzrpauvhvnexhintldqhzusndm 248 5 genetics genetic NNS work_fzrpauvhvnexhintldqhzusndm 248 6 in in IN work_fzrpauvhvnexhintldqhzusndm 248 7 shaping shape VBG work_fzrpauvhvnexhintldqhzusndm 248 8 human human NNP work_fzrpauvhvnexhintldqhzusndm 248 9 gut gut NNP work_fzrpauvhvnexhintldqhzusndm 248 10 microbiota microbiota NNP work_fzrpauvhvnexhintldqhzusndm 248 11 . . . work_fzrpauvhvnexhintldqhzusndm 249 1 Nature nature NN work_fzrpauvhvnexhintldqhzusndm 249 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 249 3 , , , work_fzrpauvhvnexhintldqhzusndm 249 4 555 555 CD work_fzrpauvhvnexhintldqhzusndm 249 5 , , , work_fzrpauvhvnexhintldqhzusndm 249 6 210–215 210–215 CD work_fzrpauvhvnexhintldqhzusndm 249 7 . . . work_fzrpauvhvnexhintldqhzusndm 250 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 250 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 250 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 250 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 250 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 250 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 250 7 10 10 CD work_fzrpauvhvnexhintldqhzusndm 250 8 . . . work_fzrpauvhvnexhintldqhzusndm 251 1 Vatanen Vatanen NNP work_fzrpauvhvnexhintldqhzusndm 251 2 , , , work_fzrpauvhvnexhintldqhzusndm 251 3 T. T. NNP work_fzrpauvhvnexhintldqhzusndm 251 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 251 5 Franzosa Franzosa NNP work_fzrpauvhvnexhintldqhzusndm 251 6 , , , work_fzrpauvhvnexhintldqhzusndm 251 7 E.A. E.A. NNP work_fzrpauvhvnexhintldqhzusndm 252 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 252 2 Schwager Schwager NNP work_fzrpauvhvnexhintldqhzusndm 252 3 , , , work_fzrpauvhvnexhintldqhzusndm 252 4 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 252 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 252 6 Tripathi Tripathi NNP work_fzrpauvhvnexhintldqhzusndm 252 7 , , , work_fzrpauvhvnexhintldqhzusndm 252 8 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 252 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 252 10 Arthur Arthur NNP work_fzrpauvhvnexhintldqhzusndm 252 11 , , , work_fzrpauvhvnexhintldqhzusndm 252 12 T.D. T.D. NNP work_fzrpauvhvnexhintldqhzusndm 253 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 253 2 Vehik Vehik NNP work_fzrpauvhvnexhintldqhzusndm 253 3 , , , work_fzrpauvhvnexhintldqhzusndm 253 4 K. K. NNP work_fzrpauvhvnexhintldqhzusndm 253 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 253 6 Lernmark Lernmark NNP work_fzrpauvhvnexhintldqhzusndm 253 7 , , , work_fzrpauvhvnexhintldqhzusndm 253 8 Å. Å. NNP work_fzrpauvhvnexhintldqhzusndm 253 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 253 10 Hagopian Hagopian NNP work_fzrpauvhvnexhintldqhzusndm 253 11 , , , work_fzrpauvhvnexhintldqhzusndm 253 12 W.A. W.A. NNP work_fzrpauvhvnexhintldqhzusndm 254 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 254 2 Rewers rewer NNS work_fzrpauvhvnexhintldqhzusndm 254 3 , , , work_fzrpauvhvnexhintldqhzusndm 254 4 M.J. M.J. NNP work_fzrpauvhvnexhintldqhzusndm 254 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 254 6 She -PRON- PRP work_fzrpauvhvnexhintldqhzusndm 254 7 , , , work_fzrpauvhvnexhintldqhzusndm 254 8 J.-X. J.-X. NNP work_fzrpauvhvnexhintldqhzusndm 255 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 255 2 Toppari Toppari NNP work_fzrpauvhvnexhintldqhzusndm 255 3 , , , work_fzrpauvhvnexhintldqhzusndm 255 4 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 255 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 255 6 et et NNP work_fzrpauvhvnexhintldqhzusndm 255 7 al al NNP work_fzrpauvhvnexhintldqhzusndm 255 8 . . . work_fzrpauvhvnexhintldqhzusndm 256 1 The the DT work_fzrpauvhvnexhintldqhzusndm 256 2 human human JJ work_fzrpauvhvnexhintldqhzusndm 256 3 gut gut NN work_fzrpauvhvnexhintldqhzusndm 256 4 microbiome microbiome NN work_fzrpauvhvnexhintldqhzusndm 256 5 in in IN work_fzrpauvhvnexhintldqhzusndm 256 6 early early JJ work_fzrpauvhvnexhintldqhzusndm 256 7 - - HYPH work_fzrpauvhvnexhintldqhzusndm 256 8 onset onset NN work_fzrpauvhvnexhintldqhzusndm 256 9 type type NN work_fzrpauvhvnexhintldqhzusndm 256 10 1 1 CD work_fzrpauvhvnexhintldqhzusndm 256 11 diabetes diabetes NN work_fzrpauvhvnexhintldqhzusndm 256 12 from from IN work_fzrpauvhvnexhintldqhzusndm 256 13 the the DT work_fzrpauvhvnexhintldqhzusndm 256 14 TEDDY TEDDY NNP work_fzrpauvhvnexhintldqhzusndm 256 15 study study NN work_fzrpauvhvnexhintldqhzusndm 256 16 . . . work_fzrpauvhvnexhintldqhzusndm 257 1 Nature nature NN work_fzrpauvhvnexhintldqhzusndm 257 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 257 3 , , , work_fzrpauvhvnexhintldqhzusndm 257 4 562 562 CD work_fzrpauvhvnexhintldqhzusndm 257 5 , , , work_fzrpauvhvnexhintldqhzusndm 257 6 589–594 589–594 CD work_fzrpauvhvnexhintldqhzusndm 257 7 . . . work_fzrpauvhvnexhintldqhzusndm 258 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 258 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 258 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 258 4 11 11 CD work_fzrpauvhvnexhintldqhzusndm 258 5 . . . work_fzrpauvhvnexhintldqhzusndm 259 1 West West NNP work_fzrpauvhvnexhintldqhzusndm 259 2 , , , work_fzrpauvhvnexhintldqhzusndm 259 3 C.E. C.E. NNP work_fzrpauvhvnexhintldqhzusndm 260 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 260 2 Renz Renz NNP work_fzrpauvhvnexhintldqhzusndm 260 3 , , , work_fzrpauvhvnexhintldqhzusndm 260 4 H. H. NNP work_fzrpauvhvnexhintldqhzusndm 260 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 260 6 Jenmalm Jenmalm NNP work_fzrpauvhvnexhintldqhzusndm 260 7 , , , work_fzrpauvhvnexhintldqhzusndm 260 8 M.C. M.C. NNP work_fzrpauvhvnexhintldqhzusndm 261 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 261 2 Kozyrskyj Kozyrskyj NNP work_fzrpauvhvnexhintldqhzusndm 261 3 , , , work_fzrpauvhvnexhintldqhzusndm 261 4 A.L. A.L. NNP work_fzrpauvhvnexhintldqhzusndm 262 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 262 2 Allen Allen NNP work_fzrpauvhvnexhintldqhzusndm 262 3 , , , work_fzrpauvhvnexhintldqhzusndm 262 4 K.J. K.J. NNP work_fzrpauvhvnexhintldqhzusndm 263 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 263 2 Vuillermin Vuillermin NNP work_fzrpauvhvnexhintldqhzusndm 263 3 , , , work_fzrpauvhvnexhintldqhzusndm 263 4 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 263 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 263 6 Prescott Prescott NNP work_fzrpauvhvnexhintldqhzusndm 263 7 , , , work_fzrpauvhvnexhintldqhzusndm 263 8 S.L. S.L. NNP work_fzrpauvhvnexhintldqhzusndm 264 1 The the DT work_fzrpauvhvnexhintldqhzusndm 264 2 gut gut NN work_fzrpauvhvnexhintldqhzusndm 264 3 microbiota microbiota NNP work_fzrpauvhvnexhintldqhzusndm 264 4 and and CC work_fzrpauvhvnexhintldqhzusndm 264 5 inflammatory inflammatory JJ work_fzrpauvhvnexhintldqhzusndm 264 6 noncommunicable noncommunicable JJ work_fzrpauvhvnexhintldqhzusndm 264 7 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 264 8 : : : work_fzrpauvhvnexhintldqhzusndm 264 9 Associations association NNS work_fzrpauvhvnexhintldqhzusndm 264 10 and and CC work_fzrpauvhvnexhintldqhzusndm 264 11 potentials potential NNS work_fzrpauvhvnexhintldqhzusndm 264 12 for for IN work_fzrpauvhvnexhintldqhzusndm 264 13 gut gut NNP work_fzrpauvhvnexhintldqhzusndm 264 14 microbiota microbiota NNP work_fzrpauvhvnexhintldqhzusndm 264 15 therapies therapy NNS work_fzrpauvhvnexhintldqhzusndm 264 16 . . . work_fzrpauvhvnexhintldqhzusndm 265 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 266 1 Allergy Allergy NNP work_fzrpauvhvnexhintldqhzusndm 266 2 Clin Clin NNP work_fzrpauvhvnexhintldqhzusndm 266 3 . . . work_fzrpauvhvnexhintldqhzusndm 267 1 Immunol immunol NN work_fzrpauvhvnexhintldqhzusndm 267 2 . . . work_fzrpauvhvnexhintldqhzusndm 268 1 2015 2015 CD work_fzrpauvhvnexhintldqhzusndm 268 2 , , , work_fzrpauvhvnexhintldqhzusndm 268 3 135 135 CD work_fzrpauvhvnexhintldqhzusndm 268 4 , , , work_fzrpauvhvnexhintldqhzusndm 268 5 3–13 3–13 CD work_fzrpauvhvnexhintldqhzusndm 268 6 . . . work_fzrpauvhvnexhintldqhzusndm 269 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 269 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 269 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 269 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 269 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 269 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 269 7 12 12 CD work_fzrpauvhvnexhintldqhzusndm 269 8 . . . work_fzrpauvhvnexhintldqhzusndm 270 1 Stein Stein NNP work_fzrpauvhvnexhintldqhzusndm 270 2 , , , work_fzrpauvhvnexhintldqhzusndm 270 3 M.M. M.M. NNP work_fzrpauvhvnexhintldqhzusndm 271 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 271 2 Hrusch Hrusch NNP work_fzrpauvhvnexhintldqhzusndm 271 3 , , , work_fzrpauvhvnexhintldqhzusndm 271 4 C.L. C.L. NNP work_fzrpauvhvnexhintldqhzusndm 272 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 272 2 Gozdz Gozdz NNP work_fzrpauvhvnexhintldqhzusndm 272 3 , , , work_fzrpauvhvnexhintldqhzusndm 272 4 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 272 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 272 6 Igartua Igartua NNP work_fzrpauvhvnexhintldqhzusndm 272 7 , , , work_fzrpauvhvnexhintldqhzusndm 272 8 C. C. NNP work_fzrpauvhvnexhintldqhzusndm 272 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 272 10 Pivniouk Pivniouk NNP work_fzrpauvhvnexhintldqhzusndm 272 11 , , , work_fzrpauvhvnexhintldqhzusndm 272 12 V. V. NNP work_fzrpauvhvnexhintldqhzusndm 272 13 ; ; : work_fzrpauvhvnexhintldqhzusndm 272 14 Murray Murray NNP work_fzrpauvhvnexhintldqhzusndm 272 15 , , , work_fzrpauvhvnexhintldqhzusndm 272 16 S.E. S.E. NNP work_fzrpauvhvnexhintldqhzusndm 273 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 273 2 Ledford Ledford NNP work_fzrpauvhvnexhintldqhzusndm 273 3 , , , work_fzrpauvhvnexhintldqhzusndm 273 4 J.G. J.G. NNP work_fzrpauvhvnexhintldqhzusndm 274 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 274 2 Marques Marques NNP work_fzrpauvhvnexhintldqhzusndm 274 3 dos dos NNP work_fzrpauvhvnexhintldqhzusndm 274 4 Santos Santos NNP work_fzrpauvhvnexhintldqhzusndm 274 5 , , , work_fzrpauvhvnexhintldqhzusndm 274 6 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 274 7 ; ; : work_fzrpauvhvnexhintldqhzusndm 274 8 Anderson Anderson NNP work_fzrpauvhvnexhintldqhzusndm 274 9 , , , work_fzrpauvhvnexhintldqhzusndm 274 10 R.L. R.L. NNP work_fzrpauvhvnexhintldqhzusndm 275 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 275 2 Metwali Metwali NNP work_fzrpauvhvnexhintldqhzusndm 275 3 , , , work_fzrpauvhvnexhintldqhzusndm 275 4 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 275 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 275 6 et et NNP work_fzrpauvhvnexhintldqhzusndm 275 7 al al NNP work_fzrpauvhvnexhintldqhzusndm 275 8 . . . work_fzrpauvhvnexhintldqhzusndm 276 1 Innate innate VB work_fzrpauvhvnexhintldqhzusndm 276 2 Immunity immunity NN work_fzrpauvhvnexhintldqhzusndm 276 3 and and CC work_fzrpauvhvnexhintldqhzusndm 276 4 Asthma Asthma NNP work_fzrpauvhvnexhintldqhzusndm 276 5 Risk Risk NNP work_fzrpauvhvnexhintldqhzusndm 276 6 in in IN work_fzrpauvhvnexhintldqhzusndm 276 7 Amish Amish NNP work_fzrpauvhvnexhintldqhzusndm 276 8 and and CC work_fzrpauvhvnexhintldqhzusndm 276 9 Hutterite Hutterite NNP work_fzrpauvhvnexhintldqhzusndm 276 10 Farm Farm NNP work_fzrpauvhvnexhintldqhzusndm 276 11 Children Children NNP work_fzrpauvhvnexhintldqhzusndm 276 12 . . . work_fzrpauvhvnexhintldqhzusndm 277 1 NEJM NEJM NNP work_fzrpauvhvnexhintldqhzusndm 277 2 2016 2016 CD work_fzrpauvhvnexhintldqhzusndm 277 3 , , , work_fzrpauvhvnexhintldqhzusndm 277 4 375 375 CD work_fzrpauvhvnexhintldqhzusndm 277 5 , , , work_fzrpauvhvnexhintldqhzusndm 277 6 411–421 411–421 CD work_fzrpauvhvnexhintldqhzusndm 277 7 . . . work_fzrpauvhvnexhintldqhzusndm 278 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 278 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 278 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 278 4 http://dx.doi.org/10.1016/j.jaci.2017.05.015 http://dx.doi.org/10.1016/j.jaci.2017.05.015 FW work_fzrpauvhvnexhintldqhzusndm 278 5 http://www.ncbi.nlm.nih.gov/pubmed/28673401 http://www.ncbi.nlm.nih.gov/pubmed/28673401 FW work_fzrpauvhvnexhintldqhzusndm 278 6 http://dx.doi.org/10.1038/s41576-018-0012-3 http://dx.doi.org/10.1038/s41576-018-0012-3 NNP work_fzrpauvhvnexhintldqhzusndm 278 7 http://www.ncbi.nlm.nih.gov/pubmed/29743650 http://www.ncbi.nlm.nih.gov/pubmed/29743650 FW work_fzrpauvhvnexhintldqhzusndm 278 8 http://dx.doi.org/10.1016/S0140-6736(17)32152-9 http://dx.doi.org/10.1016/S0140-6736(17)32152-9 NNP work_fzrpauvhvnexhintldqhzusndm 278 9 http://dx.doi.org/10.1016/j.yfrne.2012.08.006 http://dx.doi.org/10.1016/j.yfrne.2012.08.006 NNP work_fzrpauvhvnexhintldqhzusndm 278 10 http://www.ncbi.nlm.nih.gov/pubmed/22982535 http://www.ncbi.nlm.nih.gov/pubmed/22982535 UH work_fzrpauvhvnexhintldqhzusndm 278 11 http://dx.doi.org/10.1183/13993003.01930-2017 http://dx.doi.org/10.1183/13993003.01930-2017 ADD work_fzrpauvhvnexhintldqhzusndm 278 12 http://www.ncbi.nlm.nih.gov/pubmed/29545283 http://www.ncbi.nlm.nih.gov/pubmed/29545283 NNP work_fzrpauvhvnexhintldqhzusndm 278 13 http://dx.doi.org/10.1016/j.it.2015.09.009 http://dx.doi.org/10.1016/j.it.2015.09.009 NNP work_fzrpauvhvnexhintldqhzusndm 278 14 http://www.ncbi.nlm.nih.gov/pubmed/26497259 http://www.ncbi.nlm.nih.gov/pubmed/26497259 NNP work_fzrpauvhvnexhintldqhzusndm 278 15 http://dx.doi.org/10.1016/j.cell.2018.06.045 http://dx.doi.org/10.1016/j.cell.2018.06.045 NNP work_fzrpauvhvnexhintldqhzusndm 278 16 http://dx.doi.org/10.1038/nature25973 http://dx.doi.org/10.1038/nature25973 NNP work_fzrpauvhvnexhintldqhzusndm 278 17 http://www.ncbi.nlm.nih.gov/pubmed/29489753 http://www.ncbi.nlm.nih.gov/pubmed/29489753 NNP work_fzrpauvhvnexhintldqhzusndm 278 18 http://dx.doi.org/10.1038/s41586-018-0620-2 http://dx.doi.org/10.1038/s41586-018-0620-2 NN work_fzrpauvhvnexhintldqhzusndm 278 19 http://dx.doi.org/10.1016/j.jaci.2014.11.012 http://dx.doi.org/10.1016/j.jaci.2014.11.012 FW work_fzrpauvhvnexhintldqhzusndm 278 20 http://www.ncbi.nlm.nih.gov/pubmed/25567038 http://www.ncbi.nlm.nih.gov/pubmed/25567038 FW work_fzrpauvhvnexhintldqhzusndm 278 21 http://dx.doi.org/10.1056/NEJMoa1508749 http://dx.doi.org/10.1056/nejmoa1508749 UH work_fzrpauvhvnexhintldqhzusndm 278 22 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 278 23 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 278 24 , , , work_fzrpauvhvnexhintldqhzusndm 278 25 10 10 CD work_fzrpauvhvnexhintldqhzusndm 278 26 , , , work_fzrpauvhvnexhintldqhzusndm 278 27 23 23 CD work_fzrpauvhvnexhintldqhzusndm 278 28 8 8 CD work_fzrpauvhvnexhintldqhzusndm 278 29 of of IN work_fzrpauvhvnexhintldqhzusndm 278 30 9 9 CD work_fzrpauvhvnexhintldqhzusndm 278 31 13 13 CD work_fzrpauvhvnexhintldqhzusndm 278 32 . . . work_fzrpauvhvnexhintldqhzusndm 279 1 Amenyogbe Amenyogbe NNP work_fzrpauvhvnexhintldqhzusndm 279 2 , , , work_fzrpauvhvnexhintldqhzusndm 279 3 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 279 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 279 5 Kollmann Kollmann NNP work_fzrpauvhvnexhintldqhzusndm 279 6 , , , work_fzrpauvhvnexhintldqhzusndm 279 7 T.R. T.R. NNP work_fzrpauvhvnexhintldqhzusndm 280 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 280 2 Ben Ben NNP work_fzrpauvhvnexhintldqhzusndm 280 3 - - HYPH work_fzrpauvhvnexhintldqhzusndm 280 4 Othman Othman NNP work_fzrpauvhvnexhintldqhzusndm 280 5 , , , work_fzrpauvhvnexhintldqhzusndm 280 6 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 280 7 Early Early NNP work_fzrpauvhvnexhintldqhzusndm 280 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 280 9 Life Life NNP work_fzrpauvhvnexhintldqhzusndm 280 10 Host host NN work_fzrpauvhvnexhintldqhzusndm 280 11 – – : work_fzrpauvhvnexhintldqhzusndm 280 12 Microbiome microbiome JJ work_fzrpauvhvnexhintldqhzusndm 280 13 Interphase interphase NN work_fzrpauvhvnexhintldqhzusndm 280 14 : : : work_fzrpauvhvnexhintldqhzusndm 280 15 The the DT work_fzrpauvhvnexhintldqhzusndm 280 16 Key Key NNP work_fzrpauvhvnexhintldqhzusndm 280 17 Frontier Frontier NNP work_fzrpauvhvnexhintldqhzusndm 280 18 for for IN work_fzrpauvhvnexhintldqhzusndm 280 19 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 280 20 Development Development NNP work_fzrpauvhvnexhintldqhzusndm 280 21 . . . work_fzrpauvhvnexhintldqhzusndm 281 1 Front front NN work_fzrpauvhvnexhintldqhzusndm 281 2 . . . work_fzrpauvhvnexhintldqhzusndm 282 1 Pediatr Pediatr NNP work_fzrpauvhvnexhintldqhzusndm 282 2 . . . work_fzrpauvhvnexhintldqhzusndm 283 1 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 283 2 , , , work_fzrpauvhvnexhintldqhzusndm 283 3 5 5 CD work_fzrpauvhvnexhintldqhzusndm 283 4 , , , work_fzrpauvhvnexhintldqhzusndm 283 5 343 343 CD work_fzrpauvhvnexhintldqhzusndm 283 6 . . . work_fzrpauvhvnexhintldqhzusndm 284 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 284 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 284 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 284 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 284 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 284 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 284 7 14 14 CD work_fzrpauvhvnexhintldqhzusndm 284 8 . . . work_fzrpauvhvnexhintldqhzusndm 285 1 Bateson Bateson NNP work_fzrpauvhvnexhintldqhzusndm 285 2 , , , work_fzrpauvhvnexhintldqhzusndm 285 3 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 285 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 285 5 Gluckman Gluckman NNP work_fzrpauvhvnexhintldqhzusndm 285 6 , , , work_fzrpauvhvnexhintldqhzusndm 285 7 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 285 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 285 9 Hanson Hanson NNP work_fzrpauvhvnexhintldqhzusndm 285 10 , , , work_fzrpauvhvnexhintldqhzusndm 285 11 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 285 12 The the DT work_fzrpauvhvnexhintldqhzusndm 285 13 biology biology NN work_fzrpauvhvnexhintldqhzusndm 285 14 of of IN work_fzrpauvhvnexhintldqhzusndm 285 15 developmental developmental JJ work_fzrpauvhvnexhintldqhzusndm 285 16 plasticity plasticity NN work_fzrpauvhvnexhintldqhzusndm 285 17 and and CC work_fzrpauvhvnexhintldqhzusndm 285 18 the the DT work_fzrpauvhvnexhintldqhzusndm 285 19 Predictive Predictive NNP work_fzrpauvhvnexhintldqhzusndm 285 20 Adaptive Adaptive NNP work_fzrpauvhvnexhintldqhzusndm 285 21 Response Response NNP work_fzrpauvhvnexhintldqhzusndm 285 22 hypothesis hypothesis NN work_fzrpauvhvnexhintldqhzusndm 285 23 . . . work_fzrpauvhvnexhintldqhzusndm 286 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 286 2 Physiol Physiol NNP work_fzrpauvhvnexhintldqhzusndm 286 3 . . . work_fzrpauvhvnexhintldqhzusndm 287 1 2014 2014 CD work_fzrpauvhvnexhintldqhzusndm 287 2 , , , work_fzrpauvhvnexhintldqhzusndm 287 3 592 592 CD work_fzrpauvhvnexhintldqhzusndm 287 4 , , , work_fzrpauvhvnexhintldqhzusndm 287 5 2357–2368 2357–2368 CD work_fzrpauvhvnexhintldqhzusndm 287 6 . . . work_fzrpauvhvnexhintldqhzusndm 288 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 288 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 288 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 288 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 288 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 288 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 288 7 15 15 CD work_fzrpauvhvnexhintldqhzusndm 288 8 . . . work_fzrpauvhvnexhintldqhzusndm 289 1 Fleming fleming NN work_fzrpauvhvnexhintldqhzusndm 289 2 , , , work_fzrpauvhvnexhintldqhzusndm 289 3 T.P. T.P. NNP work_fzrpauvhvnexhintldqhzusndm 290 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 290 2 Watkins Watkins NNP work_fzrpauvhvnexhintldqhzusndm 290 3 , , , work_fzrpauvhvnexhintldqhzusndm 290 4 A.J. A.J. NNP work_fzrpauvhvnexhintldqhzusndm 291 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 291 2 Velazquez Velazquez NNP work_fzrpauvhvnexhintldqhzusndm 291 3 , , , work_fzrpauvhvnexhintldqhzusndm 291 4 M.A. M.A. NNP work_fzrpauvhvnexhintldqhzusndm 292 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 292 2 Mathers Mathers NNP work_fzrpauvhvnexhintldqhzusndm 292 3 , , , work_fzrpauvhvnexhintldqhzusndm 292 4 J.C. J.C. NNP work_fzrpauvhvnexhintldqhzusndm 292 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 292 6 Prentice Prentice NNP work_fzrpauvhvnexhintldqhzusndm 292 7 , , , work_fzrpauvhvnexhintldqhzusndm 292 8 A.M. A.M. NNP work_fzrpauvhvnexhintldqhzusndm 292 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 292 10 Stephenson Stephenson NNP work_fzrpauvhvnexhintldqhzusndm 292 11 , , , work_fzrpauvhvnexhintldqhzusndm 292 12 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 292 13 ; ; : work_fzrpauvhvnexhintldqhzusndm 292 14 Barker Barker NNP work_fzrpauvhvnexhintldqhzusndm 292 15 , , , work_fzrpauvhvnexhintldqhzusndm 292 16 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 292 17 ; ; : work_fzrpauvhvnexhintldqhzusndm 292 18 Saffery Saffery NNP work_fzrpauvhvnexhintldqhzusndm 292 19 , , , work_fzrpauvhvnexhintldqhzusndm 292 20 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 292 21 ; ; : work_fzrpauvhvnexhintldqhzusndm 292 22 Yajnik Yajnik NNP work_fzrpauvhvnexhintldqhzusndm 292 23 , , , work_fzrpauvhvnexhintldqhzusndm 292 24 C.S. C.S. NNP work_fzrpauvhvnexhintldqhzusndm 293 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 293 2 Eckert Eckert NNP work_fzrpauvhvnexhintldqhzusndm 293 3 , , , work_fzrpauvhvnexhintldqhzusndm 293 4 J.J. J.J. NNP work_fzrpauvhvnexhintldqhzusndm 293 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 293 6 et et NNP work_fzrpauvhvnexhintldqhzusndm 293 7 al al NNP work_fzrpauvhvnexhintldqhzusndm 293 8 . . . work_fzrpauvhvnexhintldqhzusndm 294 1 Origins Origins NNP work_fzrpauvhvnexhintldqhzusndm 294 2 of of IN work_fzrpauvhvnexhintldqhzusndm 294 3 lifetime lifetime NN work_fzrpauvhvnexhintldqhzusndm 294 4 health health NN work_fzrpauvhvnexhintldqhzusndm 294 5 around around IN work_fzrpauvhvnexhintldqhzusndm 294 6 the the DT work_fzrpauvhvnexhintldqhzusndm 294 7 time time NN work_fzrpauvhvnexhintldqhzusndm 294 8 of of IN work_fzrpauvhvnexhintldqhzusndm 294 9 conception conception NN work_fzrpauvhvnexhintldqhzusndm 294 10 : : : work_fzrpauvhvnexhintldqhzusndm 294 11 Causes cause NNS work_fzrpauvhvnexhintldqhzusndm 294 12 and and CC work_fzrpauvhvnexhintldqhzusndm 294 13 consequences consequence NNS work_fzrpauvhvnexhintldqhzusndm 294 14 . . . work_fzrpauvhvnexhintldqhzusndm 295 1 Lancet Lancet NNP work_fzrpauvhvnexhintldqhzusndm 295 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 295 3 , , , work_fzrpauvhvnexhintldqhzusndm 295 4 391 391 CD work_fzrpauvhvnexhintldqhzusndm 295 5 , , , work_fzrpauvhvnexhintldqhzusndm 295 6 1842–1852 1842–1852 CD work_fzrpauvhvnexhintldqhzusndm 295 7 . . . work_fzrpauvhvnexhintldqhzusndm 296 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 296 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 296 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 296 4 16 16 CD work_fzrpauvhvnexhintldqhzusndm 296 5 . . . work_fzrpauvhvnexhintldqhzusndm 297 1 Hanson Hanson NNP work_fzrpauvhvnexhintldqhzusndm 297 2 , , , work_fzrpauvhvnexhintldqhzusndm 297 3 M.A. M.A. NNP work_fzrpauvhvnexhintldqhzusndm 298 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 298 2 Gluckman Gluckman NNP work_fzrpauvhvnexhintldqhzusndm 298 3 , , , work_fzrpauvhvnexhintldqhzusndm 298 4 P.D. P.D. NNP work_fzrpauvhvnexhintldqhzusndm 299 1 Early early JJ work_fzrpauvhvnexhintldqhzusndm 299 2 Developmental Developmental NNP work_fzrpauvhvnexhintldqhzusndm 299 3 Conditioning Conditioning NNP work_fzrpauvhvnexhintldqhzusndm 299 4 of of IN work_fzrpauvhvnexhintldqhzusndm 299 5 Later Later NNP work_fzrpauvhvnexhintldqhzusndm 299 6 Health Health NNP work_fzrpauvhvnexhintldqhzusndm 299 7 and and CC work_fzrpauvhvnexhintldqhzusndm 299 8 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 299 9 : : : work_fzrpauvhvnexhintldqhzusndm 299 10 Physiology physiology NN work_fzrpauvhvnexhintldqhzusndm 299 11 or or CC work_fzrpauvhvnexhintldqhzusndm 299 12 Pathophysiology pathophysiology NN work_fzrpauvhvnexhintldqhzusndm 299 13 ? ? . work_fzrpauvhvnexhintldqhzusndm 300 1 Physiol Physiol NNP work_fzrpauvhvnexhintldqhzusndm 300 2 . . . work_fzrpauvhvnexhintldqhzusndm 301 1 Rev. Rev. NNP work_fzrpauvhvnexhintldqhzusndm 302 1 2014 2014 CD work_fzrpauvhvnexhintldqhzusndm 302 2 , , , work_fzrpauvhvnexhintldqhzusndm 302 3 94 94 CD work_fzrpauvhvnexhintldqhzusndm 302 4 , , , work_fzrpauvhvnexhintldqhzusndm 302 5 1027–1076 1027–1076 CD work_fzrpauvhvnexhintldqhzusndm 302 6 . . . work_fzrpauvhvnexhintldqhzusndm 303 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 303 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 303 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 303 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 303 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 303 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 303 7 17 17 CD work_fzrpauvhvnexhintldqhzusndm 303 8 . . . work_fzrpauvhvnexhintldqhzusndm 304 1 Martino Martino NNP work_fzrpauvhvnexhintldqhzusndm 304 2 , , , work_fzrpauvhvnexhintldqhzusndm 304 3 D. D. NNP work_fzrpauvhvnexhintldqhzusndm 304 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 304 5 Allen Allen NNP work_fzrpauvhvnexhintldqhzusndm 304 6 , , , work_fzrpauvhvnexhintldqhzusndm 304 7 K. K. NNP work_fzrpauvhvnexhintldqhzusndm 304 8 Meeting Meeting NNP work_fzrpauvhvnexhintldqhzusndm 304 9 the the DT work_fzrpauvhvnexhintldqhzusndm 304 10 challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 304 11 of of IN work_fzrpauvhvnexhintldqhzusndm 304 12 measuring measure VBG work_fzrpauvhvnexhintldqhzusndm 304 13 human human JJ work_fzrpauvhvnexhintldqhzusndm 304 14 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 304 15 regulation regulation NN work_fzrpauvhvnexhintldqhzusndm 304 16 . . . work_fzrpauvhvnexhintldqhzusndm 305 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 305 2 Immunol Immunol NNP work_fzrpauvhvnexhintldqhzusndm 305 3 . . . work_fzrpauvhvnexhintldqhzusndm 306 1 Methods method NNS work_fzrpauvhvnexhintldqhzusndm 306 2 2015 2015 CD work_fzrpauvhvnexhintldqhzusndm 306 3 , , , work_fzrpauvhvnexhintldqhzusndm 306 4 424 424 CD work_fzrpauvhvnexhintldqhzusndm 306 5 , , , work_fzrpauvhvnexhintldqhzusndm 306 6 1–6 1–6 CD work_fzrpauvhvnexhintldqhzusndm 306 7 . . . work_fzrpauvhvnexhintldqhzusndm 307 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 307 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 307 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 307 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 307 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 307 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 307 7 18 18 CD work_fzrpauvhvnexhintldqhzusndm 307 8 . . . work_fzrpauvhvnexhintldqhzusndm 308 1 Jiang Jiang NNP work_fzrpauvhvnexhintldqhzusndm 308 2 , , , work_fzrpauvhvnexhintldqhzusndm 308 3 C. C. NNP work_fzrpauvhvnexhintldqhzusndm 308 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 308 5 Wang Wang NNP work_fzrpauvhvnexhintldqhzusndm 308 6 , , , work_fzrpauvhvnexhintldqhzusndm 308 7 X. X. NNP work_fzrpauvhvnexhintldqhzusndm 308 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 308 9 Li Li NNP work_fzrpauvhvnexhintldqhzusndm 308 10 , , , work_fzrpauvhvnexhintldqhzusndm 308 11 X. X. NNP work_fzrpauvhvnexhintldqhzusndm 308 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 308 13 Inlora Inlora NNP work_fzrpauvhvnexhintldqhzusndm 308 14 , , , work_fzrpauvhvnexhintldqhzusndm 308 15 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 308 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 308 17 Wang Wang NNP work_fzrpauvhvnexhintldqhzusndm 308 18 , , , work_fzrpauvhvnexhintldqhzusndm 308 19 T. T. NNP work_fzrpauvhvnexhintldqhzusndm 308 20 ; ; : work_fzrpauvhvnexhintldqhzusndm 308 21 Liu Liu NNP work_fzrpauvhvnexhintldqhzusndm 308 22 , , , work_fzrpauvhvnexhintldqhzusndm 308 23 Q. Q. NNP work_fzrpauvhvnexhintldqhzusndm 308 24 ; ; : work_fzrpauvhvnexhintldqhzusndm 308 25 Snyder Snyder NNP work_fzrpauvhvnexhintldqhzusndm 308 26 , , , work_fzrpauvhvnexhintldqhzusndm 308 27 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 308 28 Dynamic Dynamic NNP work_fzrpauvhvnexhintldqhzusndm 308 29 Human Human NNP work_fzrpauvhvnexhintldqhzusndm 308 30 Environmental Environmental NNP work_fzrpauvhvnexhintldqhzusndm 308 31 Exposome Exposome NNP work_fzrpauvhvnexhintldqhzusndm 308 32 Revealed reveal VBN work_fzrpauvhvnexhintldqhzusndm 308 33 by by IN work_fzrpauvhvnexhintldqhzusndm 308 34 Longitudinal Longitudinal NNP work_fzrpauvhvnexhintldqhzusndm 308 35 Personal Personal NNP work_fzrpauvhvnexhintldqhzusndm 308 36 Monitoring Monitoring NNP work_fzrpauvhvnexhintldqhzusndm 308 37 . . . work_fzrpauvhvnexhintldqhzusndm 309 1 Cell cell NN work_fzrpauvhvnexhintldqhzusndm 309 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 309 3 , , , work_fzrpauvhvnexhintldqhzusndm 309 4 175 175 CD work_fzrpauvhvnexhintldqhzusndm 309 5 , , , work_fzrpauvhvnexhintldqhzusndm 309 6 277–291 277–291 CD work_fzrpauvhvnexhintldqhzusndm 309 7 . . . work_fzrpauvhvnexhintldqhzusndm 310 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 310 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 310 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 310 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 310 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 310 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 310 7 19 19 CD work_fzrpauvhvnexhintldqhzusndm 310 8 . . . work_fzrpauvhvnexhintldqhzusndm 311 1 Niedzwiecki Niedzwiecki NNP work_fzrpauvhvnexhintldqhzusndm 311 2 , , , work_fzrpauvhvnexhintldqhzusndm 311 3 M.M. M.M. NNP work_fzrpauvhvnexhintldqhzusndm 312 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 312 2 Walker Walker NNP work_fzrpauvhvnexhintldqhzusndm 312 3 , , , work_fzrpauvhvnexhintldqhzusndm 312 4 D.I. D.I. NNP work_fzrpauvhvnexhintldqhzusndm 313 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 313 2 Vermeulen Vermeulen NNP work_fzrpauvhvnexhintldqhzusndm 313 3 , , , work_fzrpauvhvnexhintldqhzusndm 313 4 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 313 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 313 6 Chadeau Chadeau NNP work_fzrpauvhvnexhintldqhzusndm 313 7 - - HYPH work_fzrpauvhvnexhintldqhzusndm 313 8 Hyam Hyam NNP work_fzrpauvhvnexhintldqhzusndm 313 9 , , , work_fzrpauvhvnexhintldqhzusndm 313 10 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 313 11 ; ; : work_fzrpauvhvnexhintldqhzusndm 313 12 Jones Jones NNP work_fzrpauvhvnexhintldqhzusndm 313 13 , , , work_fzrpauvhvnexhintldqhzusndm 313 14 D.P. D.P. NNP work_fzrpauvhvnexhintldqhzusndm 314 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 314 2 Miller Miller NNP work_fzrpauvhvnexhintldqhzusndm 314 3 , , , work_fzrpauvhvnexhintldqhzusndm 314 4 G.W. G.W. NNP work_fzrpauvhvnexhintldqhzusndm 315 1 The the DT work_fzrpauvhvnexhintldqhzusndm 315 2 Exposome Exposome NNP work_fzrpauvhvnexhintldqhzusndm 315 3 : : : work_fzrpauvhvnexhintldqhzusndm 315 4 Molecules molecule NNS work_fzrpauvhvnexhintldqhzusndm 315 5 to to IN work_fzrpauvhvnexhintldqhzusndm 315 6 Populations Populations NNP work_fzrpauvhvnexhintldqhzusndm 315 7 . . . work_fzrpauvhvnexhintldqhzusndm 316 1 Annu Annu NNP work_fzrpauvhvnexhintldqhzusndm 316 2 . . . work_fzrpauvhvnexhintldqhzusndm 317 1 Rev. Rev. NNP work_fzrpauvhvnexhintldqhzusndm 318 1 Pharmacol Pharmacol NNP work_fzrpauvhvnexhintldqhzusndm 318 2 . . . work_fzrpauvhvnexhintldqhzusndm 319 1 Toxicol Toxicol NNP work_fzrpauvhvnexhintldqhzusndm 319 2 . . . work_fzrpauvhvnexhintldqhzusndm 320 1 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 320 2 , , , work_fzrpauvhvnexhintldqhzusndm 320 3 59 59 CD work_fzrpauvhvnexhintldqhzusndm 320 4 , , , work_fzrpauvhvnexhintldqhzusndm 320 5 107–127 107–127 CD work_fzrpauvhvnexhintldqhzusndm 320 6 . . . work_fzrpauvhvnexhintldqhzusndm 321 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 321 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 321 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 321 4 20 20 CD work_fzrpauvhvnexhintldqhzusndm 321 5 . . . work_fzrpauvhvnexhintldqhzusndm 322 1 Ma’ayan Ma’ayan NNP work_fzrpauvhvnexhintldqhzusndm 322 2 , , , work_fzrpauvhvnexhintldqhzusndm 322 3 A. a. NN work_fzrpauvhvnexhintldqhzusndm 323 1 Complex complex JJ work_fzrpauvhvnexhintldqhzusndm 323 2 systems system NNS work_fzrpauvhvnexhintldqhzusndm 323 3 biology biology NN work_fzrpauvhvnexhintldqhzusndm 323 4 . . . work_fzrpauvhvnexhintldqhzusndm 324 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 324 2 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 324 3 Soc Soc NNP work_fzrpauvhvnexhintldqhzusndm 324 4 . . . work_fzrpauvhvnexhintldqhzusndm 325 1 Interface interface NN work_fzrpauvhvnexhintldqhzusndm 325 2 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 325 3 , , , work_fzrpauvhvnexhintldqhzusndm 325 4 14 14 CD work_fzrpauvhvnexhintldqhzusndm 325 5 , , , work_fzrpauvhvnexhintldqhzusndm 325 6 20170391 20170391 CD work_fzrpauvhvnexhintldqhzusndm 325 7 . . . work_fzrpauvhvnexhintldqhzusndm 326 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 326 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 326 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 326 4 21 21 CD work_fzrpauvhvnexhintldqhzusndm 326 5 . . . work_fzrpauvhvnexhintldqhzusndm 327 1 Zotenko Zotenko NNP work_fzrpauvhvnexhintldqhzusndm 327 2 , , , work_fzrpauvhvnexhintldqhzusndm 327 3 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 327 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 327 5 Mestre Mestre NNP work_fzrpauvhvnexhintldqhzusndm 327 6 , , , work_fzrpauvhvnexhintldqhzusndm 327 7 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 327 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 327 9 O’Leary O’Leary NNP work_fzrpauvhvnexhintldqhzusndm 327 10 , , , work_fzrpauvhvnexhintldqhzusndm 327 11 D.P. D.P. NNP work_fzrpauvhvnexhintldqhzusndm 328 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 328 2 Przytycka Przytycka NNP work_fzrpauvhvnexhintldqhzusndm 328 3 , , , work_fzrpauvhvnexhintldqhzusndm 328 4 T.M. T.M. NNP work_fzrpauvhvnexhintldqhzusndm 329 1 Why why WRB work_fzrpauvhvnexhintldqhzusndm 329 2 do do VBP work_fzrpauvhvnexhintldqhzusndm 329 3 hubs hub NNS work_fzrpauvhvnexhintldqhzusndm 329 4 in in IN work_fzrpauvhvnexhintldqhzusndm 329 5 the the DT work_fzrpauvhvnexhintldqhzusndm 329 6 yeast yeast NN work_fzrpauvhvnexhintldqhzusndm 329 7 protein protein NN work_fzrpauvhvnexhintldqhzusndm 329 8 interaction interaction NNP work_fzrpauvhvnexhintldqhzusndm 329 9 network network NN work_fzrpauvhvnexhintldqhzusndm 329 10 tend tend VBP work_fzrpauvhvnexhintldqhzusndm 329 11 to to TO work_fzrpauvhvnexhintldqhzusndm 329 12 be be VB work_fzrpauvhvnexhintldqhzusndm 329 13 essential essential JJ work_fzrpauvhvnexhintldqhzusndm 329 14 : : : work_fzrpauvhvnexhintldqhzusndm 329 15 Reexamining reexamine VBG work_fzrpauvhvnexhintldqhzusndm 329 16 the the DT work_fzrpauvhvnexhintldqhzusndm 329 17 connection connection NN work_fzrpauvhvnexhintldqhzusndm 329 18 between between IN work_fzrpauvhvnexhintldqhzusndm 329 19 the the DT work_fzrpauvhvnexhintldqhzusndm 329 20 network network NN work_fzrpauvhvnexhintldqhzusndm 329 21 topology topology NN work_fzrpauvhvnexhintldqhzusndm 329 22 and and CC work_fzrpauvhvnexhintldqhzusndm 329 23 essentiality essentiality NN work_fzrpauvhvnexhintldqhzusndm 329 24 . . . work_fzrpauvhvnexhintldqhzusndm 330 1 PLoS PLoS : work_fzrpauvhvnexhintldqhzusndm 330 2 Comput comput NN work_fzrpauvhvnexhintldqhzusndm 330 3 . . . work_fzrpauvhvnexhintldqhzusndm 330 4 ‘Biol ‘biol ADD work_fzrpauvhvnexhintldqhzusndm 330 5 . . . work_fzrpauvhvnexhintldqhzusndm 331 1 2008 2008 CD work_fzrpauvhvnexhintldqhzusndm 331 2 , , , work_fzrpauvhvnexhintldqhzusndm 331 3 4 4 CD work_fzrpauvhvnexhintldqhzusndm 331 4 , , , work_fzrpauvhvnexhintldqhzusndm 331 5 e1000140 e1000140 NN work_fzrpauvhvnexhintldqhzusndm 331 6 . . . work_fzrpauvhvnexhintldqhzusndm 332 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 332 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 332 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 332 4 22 22 CD work_fzrpauvhvnexhintldqhzusndm 332 5 . . . work_fzrpauvhvnexhintldqhzusndm 333 1 Chevrier Chevrier NNP work_fzrpauvhvnexhintldqhzusndm 333 2 , , , work_fzrpauvhvnexhintldqhzusndm 333 3 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 333 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 333 5 Mertins Mertins NNP work_fzrpauvhvnexhintldqhzusndm 333 6 , , , work_fzrpauvhvnexhintldqhzusndm 333 7 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 333 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 333 9 Artyomov Artyomov NNP work_fzrpauvhvnexhintldqhzusndm 333 10 , , , work_fzrpauvhvnexhintldqhzusndm 333 11 M.N. M.N. NNP work_fzrpauvhvnexhintldqhzusndm 334 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 334 2 Shalek Shalek NNP work_fzrpauvhvnexhintldqhzusndm 334 3 , , , work_fzrpauvhvnexhintldqhzusndm 334 4 A.K. A.K. NNP work_fzrpauvhvnexhintldqhzusndm 335 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 335 2 Iannacone Iannacone NNP work_fzrpauvhvnexhintldqhzusndm 335 3 , , , work_fzrpauvhvnexhintldqhzusndm 335 4 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 335 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 335 6 Ciaccio Ciaccio NNP work_fzrpauvhvnexhintldqhzusndm 335 7 , , , work_fzrpauvhvnexhintldqhzusndm 335 8 M.F. M.F. NNP work_fzrpauvhvnexhintldqhzusndm 336 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 336 2 Gat Gat NNP work_fzrpauvhvnexhintldqhzusndm 336 3 - - HYPH work_fzrpauvhvnexhintldqhzusndm 336 4 Viks Viks NNP work_fzrpauvhvnexhintldqhzusndm 336 5 , , , work_fzrpauvhvnexhintldqhzusndm 336 6 I. i. NN work_fzrpauvhvnexhintldqhzusndm 336 7 ; ; : work_fzrpauvhvnexhintldqhzusndm 336 8 Tonti Tonti NNP work_fzrpauvhvnexhintldqhzusndm 336 9 , , , work_fzrpauvhvnexhintldqhzusndm 336 10 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 336 11 ; ; : work_fzrpauvhvnexhintldqhzusndm 336 12 DeGrace DeGrace NNP work_fzrpauvhvnexhintldqhzusndm 336 13 , , , work_fzrpauvhvnexhintldqhzusndm 336 14 M.M. M.M. NNP work_fzrpauvhvnexhintldqhzusndm 337 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 337 2 Clauser Clauser NNP work_fzrpauvhvnexhintldqhzusndm 337 3 , , , work_fzrpauvhvnexhintldqhzusndm 337 4 K.R. K.R. NNP work_fzrpauvhvnexhintldqhzusndm 338 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 338 2 et et NNP work_fzrpauvhvnexhintldqhzusndm 338 3 al al NNP work_fzrpauvhvnexhintldqhzusndm 338 4 . . . work_fzrpauvhvnexhintldqhzusndm 339 1 Systematic systematic JJ work_fzrpauvhvnexhintldqhzusndm 339 2 discovery discovery NN work_fzrpauvhvnexhintldqhzusndm 339 3 of of IN work_fzrpauvhvnexhintldqhzusndm 339 4 TLR tlr NN work_fzrpauvhvnexhintldqhzusndm 339 5 signaling signal VBG work_fzrpauvhvnexhintldqhzusndm 339 6 components component NNS work_fzrpauvhvnexhintldqhzusndm 339 7 delineates delineate VBZ work_fzrpauvhvnexhintldqhzusndm 339 8 viral viral NN work_fzrpauvhvnexhintldqhzusndm 339 9 - - HYPH work_fzrpauvhvnexhintldqhzusndm 339 10 sensing sense VBG work_fzrpauvhvnexhintldqhzusndm 339 11 circuits circuit NNS work_fzrpauvhvnexhintldqhzusndm 339 12 . . . work_fzrpauvhvnexhintldqhzusndm 340 1 Cell cell NN work_fzrpauvhvnexhintldqhzusndm 340 2 2011 2011 CD work_fzrpauvhvnexhintldqhzusndm 340 3 , , , work_fzrpauvhvnexhintldqhzusndm 340 4 147 147 CD work_fzrpauvhvnexhintldqhzusndm 340 5 , , , work_fzrpauvhvnexhintldqhzusndm 340 6 853–867 853–867 CD work_fzrpauvhvnexhintldqhzusndm 340 7 . . . work_fzrpauvhvnexhintldqhzusndm 341 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 341 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 341 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 341 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 341 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 341 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 341 7 23 23 CD work_fzrpauvhvnexhintldqhzusndm 341 8 . . . work_fzrpauvhvnexhintldqhzusndm 342 1 Bosco bosco NN work_fzrpauvhvnexhintldqhzusndm 342 2 , , , work_fzrpauvhvnexhintldqhzusndm 342 3 A. a. NN work_fzrpauvhvnexhintldqhzusndm 342 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 342 5 Ehteshami Ehteshami NNP work_fzrpauvhvnexhintldqhzusndm 342 6 , , , work_fzrpauvhvnexhintldqhzusndm 342 7 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 342 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 342 9 Panyala Panyala NNP work_fzrpauvhvnexhintldqhzusndm 342 10 , , , work_fzrpauvhvnexhintldqhzusndm 342 11 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 342 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 342 13 Martinez Martinez NNP work_fzrpauvhvnexhintldqhzusndm 342 14 , , , work_fzrpauvhvnexhintldqhzusndm 342 15 F.D. F.D. NNP work_fzrpauvhvnexhintldqhzusndm 343 1 Interferon Interferon NNP work_fzrpauvhvnexhintldqhzusndm 343 2 regulatory regulatory JJ work_fzrpauvhvnexhintldqhzusndm 343 3 factor factor NN work_fzrpauvhvnexhintldqhzusndm 343 4 7 7 CD work_fzrpauvhvnexhintldqhzusndm 343 5 is be VBZ work_fzrpauvhvnexhintldqhzusndm 343 6 a a DT work_fzrpauvhvnexhintldqhzusndm 343 7 major major JJ work_fzrpauvhvnexhintldqhzusndm 343 8 hub hub NN work_fzrpauvhvnexhintldqhzusndm 343 9 connecting connect VBG work_fzrpauvhvnexhintldqhzusndm 343 10 interferon interferon NNP work_fzrpauvhvnexhintldqhzusndm 343 11 - - HYPH work_fzrpauvhvnexhintldqhzusndm 343 12 mediated mediate VBN work_fzrpauvhvnexhintldqhzusndm 343 13 responses response NNS work_fzrpauvhvnexhintldqhzusndm 343 14 in in IN work_fzrpauvhvnexhintldqhzusndm 343 15 virus virus NN work_fzrpauvhvnexhintldqhzusndm 343 16 - - HYPH work_fzrpauvhvnexhintldqhzusndm 343 17 induced induce VBN work_fzrpauvhvnexhintldqhzusndm 343 18 asthma asthma NN work_fzrpauvhvnexhintldqhzusndm 343 19 exacerbations exacerbation NNS work_fzrpauvhvnexhintldqhzusndm 343 20 in in IN work_fzrpauvhvnexhintldqhzusndm 343 21 vivo vivo NNP work_fzrpauvhvnexhintldqhzusndm 343 22 . . . work_fzrpauvhvnexhintldqhzusndm 344 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 345 1 Allergy Allergy NNP work_fzrpauvhvnexhintldqhzusndm 345 2 Clin Clin NNP work_fzrpauvhvnexhintldqhzusndm 345 3 . . . work_fzrpauvhvnexhintldqhzusndm 346 1 Immunol immunol NN work_fzrpauvhvnexhintldqhzusndm 346 2 . . . work_fzrpauvhvnexhintldqhzusndm 347 1 2012 2012 CD work_fzrpauvhvnexhintldqhzusndm 347 2 , , , work_fzrpauvhvnexhintldqhzusndm 347 3 129 129 CD work_fzrpauvhvnexhintldqhzusndm 347 4 , , , work_fzrpauvhvnexhintldqhzusndm 347 5 88–94 88–94 CD work_fzrpauvhvnexhintldqhzusndm 347 6 . . . work_fzrpauvhvnexhintldqhzusndm 348 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 348 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 348 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 348 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 348 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 348 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 348 7 24 24 CD work_fzrpauvhvnexhintldqhzusndm 348 8 . . . work_fzrpauvhvnexhintldqhzusndm 349 1 Barabási Barabási NNP work_fzrpauvhvnexhintldqhzusndm 349 2 , , , work_fzrpauvhvnexhintldqhzusndm 349 3 A.-L. a.-l. XX work_fzrpauvhvnexhintldqhzusndm 349 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 349 5 Gulbahce Gulbahce NNP work_fzrpauvhvnexhintldqhzusndm 349 6 , , , work_fzrpauvhvnexhintldqhzusndm 349 7 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 349 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 349 9 Loscalzo Loscalzo NNP work_fzrpauvhvnexhintldqhzusndm 349 10 , , , work_fzrpauvhvnexhintldqhzusndm 349 11 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 350 1 Network network NN work_fzrpauvhvnexhintldqhzusndm 350 2 medicine medicine NN work_fzrpauvhvnexhintldqhzusndm 350 3 : : : work_fzrpauvhvnexhintldqhzusndm 350 4 A a DT work_fzrpauvhvnexhintldqhzusndm 350 5 network network NN work_fzrpauvhvnexhintldqhzusndm 350 6 - - HYPH work_fzrpauvhvnexhintldqhzusndm 350 7 based base VBN work_fzrpauvhvnexhintldqhzusndm 350 8 approach approach NN work_fzrpauvhvnexhintldqhzusndm 350 9 to to IN work_fzrpauvhvnexhintldqhzusndm 350 10 human human JJ work_fzrpauvhvnexhintldqhzusndm 350 11 disease disease NN work_fzrpauvhvnexhintldqhzusndm 350 12 . . . work_fzrpauvhvnexhintldqhzusndm 351 1 Nat Nat NNP work_fzrpauvhvnexhintldqhzusndm 351 2 . . . work_fzrpauvhvnexhintldqhzusndm 352 1 Rev. Rev. NNP work_fzrpauvhvnexhintldqhzusndm 353 1 Genet Genet NNP work_fzrpauvhvnexhintldqhzusndm 353 2 . . . work_fzrpauvhvnexhintldqhzusndm 354 1 2011 2011 CD work_fzrpauvhvnexhintldqhzusndm 354 2 , , , work_fzrpauvhvnexhintldqhzusndm 354 3 12 12 CD work_fzrpauvhvnexhintldqhzusndm 354 4 , , , work_fzrpauvhvnexhintldqhzusndm 354 5 56–68 56–68 CD work_fzrpauvhvnexhintldqhzusndm 354 6 . . . work_fzrpauvhvnexhintldqhzusndm 355 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 355 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 355 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 355 4 25 25 CD work_fzrpauvhvnexhintldqhzusndm 355 5 . . . work_fzrpauvhvnexhintldqhzusndm 356 1 Kitano Kitano NNP work_fzrpauvhvnexhintldqhzusndm 356 2 , , , work_fzrpauvhvnexhintldqhzusndm 356 3 H. H. NNP work_fzrpauvhvnexhintldqhzusndm 356 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 356 5 Oda Oda NNP work_fzrpauvhvnexhintldqhzusndm 356 6 , , , work_fzrpauvhvnexhintldqhzusndm 356 7 K. K. NNP work_fzrpauvhvnexhintldqhzusndm 356 8 Robustness Robustness NNP work_fzrpauvhvnexhintldqhzusndm 356 9 trade trade NN work_fzrpauvhvnexhintldqhzusndm 356 10 - - HYPH work_fzrpauvhvnexhintldqhzusndm 356 11 offs off NNS work_fzrpauvhvnexhintldqhzusndm 356 12 and and CC work_fzrpauvhvnexhintldqhzusndm 356 13 host host NN work_fzrpauvhvnexhintldqhzusndm 356 14 - - HYPH work_fzrpauvhvnexhintldqhzusndm 356 15 microbial microbial JJ work_fzrpauvhvnexhintldqhzusndm 356 16 symbiosis symbiosis NN work_fzrpauvhvnexhintldqhzusndm 356 17 in in IN work_fzrpauvhvnexhintldqhzusndm 356 18 the the DT work_fzrpauvhvnexhintldqhzusndm 356 19 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 356 20 system system NN work_fzrpauvhvnexhintldqhzusndm 356 21 . . . work_fzrpauvhvnexhintldqhzusndm 357 1 Mol Mol NNP work_fzrpauvhvnexhintldqhzusndm 357 2 . . . work_fzrpauvhvnexhintldqhzusndm 358 1 Syst Syst NNP work_fzrpauvhvnexhintldqhzusndm 358 2 . . . work_fzrpauvhvnexhintldqhzusndm 359 1 Biol Biol NNP work_fzrpauvhvnexhintldqhzusndm 359 2 . . . work_fzrpauvhvnexhintldqhzusndm 360 1 2006 2006 CD work_fzrpauvhvnexhintldqhzusndm 360 2 , , , work_fzrpauvhvnexhintldqhzusndm 360 3 2 2 CD work_fzrpauvhvnexhintldqhzusndm 360 4 . . . work_fzrpauvhvnexhintldqhzusndm 361 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 361 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 361 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 361 4 26 26 CD work_fzrpauvhvnexhintldqhzusndm 361 5 . . . work_fzrpauvhvnexhintldqhzusndm 362 1 Price price NN work_fzrpauvhvnexhintldqhzusndm 362 2 , , , work_fzrpauvhvnexhintldqhzusndm 362 3 N.D. North Dakota NNP work_fzrpauvhvnexhintldqhzusndm 362 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 362 5 Magis Magis NNP work_fzrpauvhvnexhintldqhzusndm 362 6 , , , work_fzrpauvhvnexhintldqhzusndm 362 7 A.T. A.T. NNP work_fzrpauvhvnexhintldqhzusndm 362 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 362 9 Earls Earls NNP work_fzrpauvhvnexhintldqhzusndm 362 10 , , , work_fzrpauvhvnexhintldqhzusndm 362 11 J.C. J.C. NNP work_fzrpauvhvnexhintldqhzusndm 362 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 362 13 Glusman Glusman NNP work_fzrpauvhvnexhintldqhzusndm 362 14 , , , work_fzrpauvhvnexhintldqhzusndm 362 15 G. G. NNP work_fzrpauvhvnexhintldqhzusndm 362 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 362 17 Nature Nature NNP work_fzrpauvhvnexhintldqhzusndm 362 18 , , , work_fzrpauvhvnexhintldqhzusndm 362 19 R.L. R.L. NNP work_fzrpauvhvnexhintldqhzusndm 363 1 A a DT work_fzrpauvhvnexhintldqhzusndm 363 2 wellness wellness NN work_fzrpauvhvnexhintldqhzusndm 363 3 study study NN work_fzrpauvhvnexhintldqhzusndm 363 4 of of IN work_fzrpauvhvnexhintldqhzusndm 363 5 108 108 CD work_fzrpauvhvnexhintldqhzusndm 363 6 individuals individual NNS work_fzrpauvhvnexhintldqhzusndm 363 7 using use VBG work_fzrpauvhvnexhintldqhzusndm 363 8 personal personal JJ work_fzrpauvhvnexhintldqhzusndm 363 9 , , , work_fzrpauvhvnexhintldqhzusndm 363 10 dense dense JJ work_fzrpauvhvnexhintldqhzusndm 363 11 , , , work_fzrpauvhvnexhintldqhzusndm 363 12 dynamic dynamic JJ work_fzrpauvhvnexhintldqhzusndm 363 13 data datum NNS work_fzrpauvhvnexhintldqhzusndm 363 14 clouds cloud NNS work_fzrpauvhvnexhintldqhzusndm 363 15 . . . work_fzrpauvhvnexhintldqhzusndm 364 1 Nat Nat NNP work_fzrpauvhvnexhintldqhzusndm 364 2 . . . work_fzrpauvhvnexhintldqhzusndm 365 1 Biotechnol Biotechnol NNS work_fzrpauvhvnexhintldqhzusndm 365 2 . . . work_fzrpauvhvnexhintldqhzusndm 366 1 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 366 2 , , , work_fzrpauvhvnexhintldqhzusndm 366 3 35 35 CD work_fzrpauvhvnexhintldqhzusndm 366 4 , , , work_fzrpauvhvnexhintldqhzusndm 366 5 747–756 747–756 CD work_fzrpauvhvnexhintldqhzusndm 366 6 . . . work_fzrpauvhvnexhintldqhzusndm 367 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 367 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 367 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 367 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 367 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 367 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 367 7 27 27 CD work_fzrpauvhvnexhintldqhzusndm 367 8 . . . work_fzrpauvhvnexhintldqhzusndm 368 1 Lewis Lewis NNP work_fzrpauvhvnexhintldqhzusndm 368 2 , , , work_fzrpauvhvnexhintldqhzusndm 368 3 C.M. C.M. NNP work_fzrpauvhvnexhintldqhzusndm 369 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 369 2 Vassos Vassos NNP work_fzrpauvhvnexhintldqhzusndm 369 3 , , , work_fzrpauvhvnexhintldqhzusndm 369 4 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 369 5 Prospects Prospects NNP work_fzrpauvhvnexhintldqhzusndm 369 6 for for IN work_fzrpauvhvnexhintldqhzusndm 369 7 using use VBG work_fzrpauvhvnexhintldqhzusndm 369 8 risk risk NN work_fzrpauvhvnexhintldqhzusndm 369 9 scores score NNS work_fzrpauvhvnexhintldqhzusndm 369 10 in in IN work_fzrpauvhvnexhintldqhzusndm 369 11 polygenic polygenic NN work_fzrpauvhvnexhintldqhzusndm 369 12 medicine medicine NN work_fzrpauvhvnexhintldqhzusndm 369 13 . . . work_fzrpauvhvnexhintldqhzusndm 370 1 Genome genome JJ work_fzrpauvhvnexhintldqhzusndm 370 2 Med Med NNP work_fzrpauvhvnexhintldqhzusndm 370 3 . . . work_fzrpauvhvnexhintldqhzusndm 371 1 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 371 2 , , , work_fzrpauvhvnexhintldqhzusndm 371 3 9 9 CD work_fzrpauvhvnexhintldqhzusndm 371 4 , , , work_fzrpauvhvnexhintldqhzusndm 371 5 96 96 CD work_fzrpauvhvnexhintldqhzusndm 371 6 . . . work_fzrpauvhvnexhintldqhzusndm 372 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 372 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 372 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 372 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 372 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 372 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 372 7 28 28 CD work_fzrpauvhvnexhintldqhzusndm 372 8 . . . work_fzrpauvhvnexhintldqhzusndm 373 1 Dinalankara Dinalankara NNP work_fzrpauvhvnexhintldqhzusndm 373 2 , , , work_fzrpauvhvnexhintldqhzusndm 373 3 W. W. NNP work_fzrpauvhvnexhintldqhzusndm 373 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 373 5 Ke Ke NNP work_fzrpauvhvnexhintldqhzusndm 373 6 , , , work_fzrpauvhvnexhintldqhzusndm 373 7 Q. Q. NNP work_fzrpauvhvnexhintldqhzusndm 373 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 373 9 Xu Xu NNP work_fzrpauvhvnexhintldqhzusndm 373 10 , , , work_fzrpauvhvnexhintldqhzusndm 373 11 Y. Y. NNP work_fzrpauvhvnexhintldqhzusndm 373 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 373 13 Ji Ji NNP work_fzrpauvhvnexhintldqhzusndm 373 14 , , , work_fzrpauvhvnexhintldqhzusndm 373 15 L. L. NNP work_fzrpauvhvnexhintldqhzusndm 373 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 373 17 Pagane Pagane NNP work_fzrpauvhvnexhintldqhzusndm 373 18 , , , work_fzrpauvhvnexhintldqhzusndm 373 19 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 373 20 ; ; : work_fzrpauvhvnexhintldqhzusndm 373 21 Lien Lien NNP work_fzrpauvhvnexhintldqhzusndm 373 22 , , , work_fzrpauvhvnexhintldqhzusndm 373 23 A. a. NN work_fzrpauvhvnexhintldqhzusndm 373 24 ; ; : work_fzrpauvhvnexhintldqhzusndm 373 25 Matam Matam NNP work_fzrpauvhvnexhintldqhzusndm 373 26 , , , work_fzrpauvhvnexhintldqhzusndm 373 27 T. t. NN work_fzrpauvhvnexhintldqhzusndm 373 28 ; ; : work_fzrpauvhvnexhintldqhzusndm 373 29 Fertig Fertig NNP work_fzrpauvhvnexhintldqhzusndm 373 30 , , , work_fzrpauvhvnexhintldqhzusndm 373 31 E.J. E.J. NNP work_fzrpauvhvnexhintldqhzusndm 374 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 374 2 Price Price NNP work_fzrpauvhvnexhintldqhzusndm 374 3 , , , work_fzrpauvhvnexhintldqhzusndm 374 4 N.D. North Dakota NNP work_fzrpauvhvnexhintldqhzusndm 374 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 374 6 Younes Younes NNP work_fzrpauvhvnexhintldqhzusndm 374 7 , , , work_fzrpauvhvnexhintldqhzusndm 374 8 L. L. NNP work_fzrpauvhvnexhintldqhzusndm 374 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 374 10 et et NNP work_fzrpauvhvnexhintldqhzusndm 374 11 al al NNP work_fzrpauvhvnexhintldqhzusndm 374 12 . . . work_fzrpauvhvnexhintldqhzusndm 375 1 Digitizing digitize VBG work_fzrpauvhvnexhintldqhzusndm 375 2 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 375 3 profiles profile NNS work_fzrpauvhvnexhintldqhzusndm 375 4 by by IN work_fzrpauvhvnexhintldqhzusndm 375 5 divergence divergence NN work_fzrpauvhvnexhintldqhzusndm 375 6 from from IN work_fzrpauvhvnexhintldqhzusndm 375 7 a a DT work_fzrpauvhvnexhintldqhzusndm 375 8 baseline baseline NN work_fzrpauvhvnexhintldqhzusndm 375 9 . . . work_fzrpauvhvnexhintldqhzusndm 376 1 Proc Proc NNP work_fzrpauvhvnexhintldqhzusndm 376 2 . . . work_fzrpauvhvnexhintldqhzusndm 377 1 Natl Natl NNP work_fzrpauvhvnexhintldqhzusndm 377 2 . . . work_fzrpauvhvnexhintldqhzusndm 378 1 Acad Acad NNS work_fzrpauvhvnexhintldqhzusndm 378 2 . . . work_fzrpauvhvnexhintldqhzusndm 379 1 Sci Sci NNP work_fzrpauvhvnexhintldqhzusndm 379 2 . . . work_fzrpauvhvnexhintldqhzusndm 380 1 USA USA NNP work_fzrpauvhvnexhintldqhzusndm 380 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 380 3 , , , work_fzrpauvhvnexhintldqhzusndm 380 4 115 115 CD work_fzrpauvhvnexhintldqhzusndm 380 5 , , , work_fzrpauvhvnexhintldqhzusndm 380 6 4545–4552 4545–4552 CD work_fzrpauvhvnexhintldqhzusndm 380 7 . . . work_fzrpauvhvnexhintldqhzusndm 381 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 381 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 381 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 381 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 381 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 381 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 381 7 29 29 CD work_fzrpauvhvnexhintldqhzusndm 381 8 . . . work_fzrpauvhvnexhintldqhzusndm 382 1 Martinez Martinez NNP work_fzrpauvhvnexhintldqhzusndm 382 2 , , , work_fzrpauvhvnexhintldqhzusndm 382 3 F.D. F.D. NNP work_fzrpauvhvnexhintldqhzusndm 383 1 Early early JJ work_fzrpauvhvnexhintldqhzusndm 383 2 - - HYPH work_fzrpauvhvnexhintldqhzusndm 383 3 Life Life NNP work_fzrpauvhvnexhintldqhzusndm 383 4 Origins Origins NNP work_fzrpauvhvnexhintldqhzusndm 383 5 of of IN work_fzrpauvhvnexhintldqhzusndm 383 6 Chronic Chronic NNP work_fzrpauvhvnexhintldqhzusndm 383 7 Obstructive Obstructive NNP work_fzrpauvhvnexhintldqhzusndm 383 8 Pulmonary Pulmonary NNP work_fzrpauvhvnexhintldqhzusndm 383 9 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 383 10 . . . work_fzrpauvhvnexhintldqhzusndm 384 1 NEJM NEJM NNP work_fzrpauvhvnexhintldqhzusndm 384 2 2016 2016 CD work_fzrpauvhvnexhintldqhzusndm 384 3 , , , work_fzrpauvhvnexhintldqhzusndm 384 4 375 375 CD work_fzrpauvhvnexhintldqhzusndm 384 5 , , , work_fzrpauvhvnexhintldqhzusndm 384 6 871–878 871–878 CD work_fzrpauvhvnexhintldqhzusndm 384 7 . . . work_fzrpauvhvnexhintldqhzusndm 385 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 385 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 385 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 385 4 30 30 CD work_fzrpauvhvnexhintldqhzusndm 385 5 . . . work_fzrpauvhvnexhintldqhzusndm 386 1 Torkamani Torkamani NNP work_fzrpauvhvnexhintldqhzusndm 386 2 , , , work_fzrpauvhvnexhintldqhzusndm 386 3 A. a. NN work_fzrpauvhvnexhintldqhzusndm 386 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 386 5 Wineinger Wineinger NNP work_fzrpauvhvnexhintldqhzusndm 386 6 , , , work_fzrpauvhvnexhintldqhzusndm 386 7 N.E. N.E. NNP work_fzrpauvhvnexhintldqhzusndm 387 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 387 2 Topol Topol NNP work_fzrpauvhvnexhintldqhzusndm 387 3 , , , work_fzrpauvhvnexhintldqhzusndm 387 4 E.J. E.J. NNP work_fzrpauvhvnexhintldqhzusndm 388 1 The the DT work_fzrpauvhvnexhintldqhzusndm 388 2 personal personal JJ work_fzrpauvhvnexhintldqhzusndm 388 3 and and CC work_fzrpauvhvnexhintldqhzusndm 388 4 clinical clinical JJ work_fzrpauvhvnexhintldqhzusndm 388 5 utility utility NN work_fzrpauvhvnexhintldqhzusndm 388 6 of of IN work_fzrpauvhvnexhintldqhzusndm 388 7 polygenic polygenic JJ work_fzrpauvhvnexhintldqhzusndm 388 8 risk risk NN work_fzrpauvhvnexhintldqhzusndm 388 9 scores score NNS work_fzrpauvhvnexhintldqhzusndm 388 10 . . . work_fzrpauvhvnexhintldqhzusndm 389 1 Nat Nat NNP work_fzrpauvhvnexhintldqhzusndm 389 2 . . . work_fzrpauvhvnexhintldqhzusndm 390 1 Rev. Rev. NNP work_fzrpauvhvnexhintldqhzusndm 391 1 Genet Genet NNP work_fzrpauvhvnexhintldqhzusndm 391 2 . . . work_fzrpauvhvnexhintldqhzusndm 392 1 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 392 2 , , , work_fzrpauvhvnexhintldqhzusndm 392 3 19 19 CD work_fzrpauvhvnexhintldqhzusndm 392 4 , , , work_fzrpauvhvnexhintldqhzusndm 392 5 581–590 581–590 CD work_fzrpauvhvnexhintldqhzusndm 392 6 . . . work_fzrpauvhvnexhintldqhzusndm 393 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 393 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 393 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 393 4 31 31 CD work_fzrpauvhvnexhintldqhzusndm 393 5 . . . work_fzrpauvhvnexhintldqhzusndm 394 1 Khera Khera NNP work_fzrpauvhvnexhintldqhzusndm 394 2 , , , work_fzrpauvhvnexhintldqhzusndm 394 3 A.V. A.V. NNP work_fzrpauvhvnexhintldqhzusndm 395 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 395 2 Chaffin Chaffin NNP work_fzrpauvhvnexhintldqhzusndm 395 3 , , , work_fzrpauvhvnexhintldqhzusndm 395 4 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 395 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 395 6 Aragam Aragam NNP work_fzrpauvhvnexhintldqhzusndm 395 7 , , , work_fzrpauvhvnexhintldqhzusndm 395 8 K.G. K.G. NNP work_fzrpauvhvnexhintldqhzusndm 396 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 396 2 Haas Haas NNP work_fzrpauvhvnexhintldqhzusndm 396 3 , , , work_fzrpauvhvnexhintldqhzusndm 396 4 M.E. M.E. NNP work_fzrpauvhvnexhintldqhzusndm 397 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 397 2 Roselli Roselli NNP work_fzrpauvhvnexhintldqhzusndm 397 3 , , , work_fzrpauvhvnexhintldqhzusndm 397 4 C. C. NNP work_fzrpauvhvnexhintldqhzusndm 397 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 397 6 Choi Choi NNP work_fzrpauvhvnexhintldqhzusndm 397 7 , , , work_fzrpauvhvnexhintldqhzusndm 397 8 S.H. S.H. NNP work_fzrpauvhvnexhintldqhzusndm 398 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 398 2 Natarajan Natarajan NNP work_fzrpauvhvnexhintldqhzusndm 398 3 , , , work_fzrpauvhvnexhintldqhzusndm 398 4 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 398 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 398 6 Lander Lander NNP work_fzrpauvhvnexhintldqhzusndm 398 7 , , , work_fzrpauvhvnexhintldqhzusndm 398 8 E.S. E.S. NNP work_fzrpauvhvnexhintldqhzusndm 399 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 399 2 Lubitz Lubitz NNP work_fzrpauvhvnexhintldqhzusndm 399 3 , , , work_fzrpauvhvnexhintldqhzusndm 399 4 S.A. S.A. NNP work_fzrpauvhvnexhintldqhzusndm 399 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 399 6 Ellinor Ellinor NNP work_fzrpauvhvnexhintldqhzusndm 399 7 , , , work_fzrpauvhvnexhintldqhzusndm 399 8 P.T. P.T. NNP work_fzrpauvhvnexhintldqhzusndm 400 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 400 2 et et NNP work_fzrpauvhvnexhintldqhzusndm 400 3 al al NNP work_fzrpauvhvnexhintldqhzusndm 400 4 . . . work_fzrpauvhvnexhintldqhzusndm 401 1 Genome genome RB work_fzrpauvhvnexhintldqhzusndm 401 2 - - HYPH work_fzrpauvhvnexhintldqhzusndm 401 3 wide wide JJ work_fzrpauvhvnexhintldqhzusndm 401 4 polygenic polygenic JJ work_fzrpauvhvnexhintldqhzusndm 401 5 scores score NNS work_fzrpauvhvnexhintldqhzusndm 401 6 for for IN work_fzrpauvhvnexhintldqhzusndm 401 7 common common JJ work_fzrpauvhvnexhintldqhzusndm 401 8 diseases disease NNS work_fzrpauvhvnexhintldqhzusndm 401 9 identify identify VBP work_fzrpauvhvnexhintldqhzusndm 401 10 individuals individual NNS work_fzrpauvhvnexhintldqhzusndm 401 11 with with IN work_fzrpauvhvnexhintldqhzusndm 401 12 risk risk NN work_fzrpauvhvnexhintldqhzusndm 401 13 equivalent equivalent JJ work_fzrpauvhvnexhintldqhzusndm 401 14 to to IN work_fzrpauvhvnexhintldqhzusndm 401 15 monogenic monogenic JJ work_fzrpauvhvnexhintldqhzusndm 401 16 mutations mutation NNS work_fzrpauvhvnexhintldqhzusndm 401 17 . . . work_fzrpauvhvnexhintldqhzusndm 402 1 Nat Nat NNP work_fzrpauvhvnexhintldqhzusndm 402 2 . . . work_fzrpauvhvnexhintldqhzusndm 403 1 Genet Genet NNP work_fzrpauvhvnexhintldqhzusndm 403 2 . . . work_fzrpauvhvnexhintldqhzusndm 404 1 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 404 2 , , , work_fzrpauvhvnexhintldqhzusndm 404 3 50 50 CD work_fzrpauvhvnexhintldqhzusndm 404 4 , , , work_fzrpauvhvnexhintldqhzusndm 404 5 1219–1224 1219–1224 CD work_fzrpauvhvnexhintldqhzusndm 404 6 . . . work_fzrpauvhvnexhintldqhzusndm 405 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 405 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 405 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 405 4 32 32 CD work_fzrpauvhvnexhintldqhzusndm 405 5 . . . work_fzrpauvhvnexhintldqhzusndm 406 1 Tang Tang NNP work_fzrpauvhvnexhintldqhzusndm 406 2 , , , work_fzrpauvhvnexhintldqhzusndm 406 3 H.H. H.H. NNP work_fzrpauvhvnexhintldqhzusndm 407 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 407 2 Teo Teo NNP work_fzrpauvhvnexhintldqhzusndm 407 3 , , , work_fzrpauvhvnexhintldqhzusndm 407 4 S.M. S.M. NNP work_fzrpauvhvnexhintldqhzusndm 408 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 408 2 Belgrave Belgrave NNP work_fzrpauvhvnexhintldqhzusndm 408 3 , , , work_fzrpauvhvnexhintldqhzusndm 408 4 D.C. D.C. NNP work_fzrpauvhvnexhintldqhzusndm 408 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 408 6 Evans Evans NNP work_fzrpauvhvnexhintldqhzusndm 408 7 , , , work_fzrpauvhvnexhintldqhzusndm 408 8 M.D. M.D. NNP work_fzrpauvhvnexhintldqhzusndm 409 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 409 2 Jackson Jackson NNP work_fzrpauvhvnexhintldqhzusndm 409 3 , , , work_fzrpauvhvnexhintldqhzusndm 409 4 D.J. D.J. NNP work_fzrpauvhvnexhintldqhzusndm 410 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 410 2 Brozynska Brozynska NNP work_fzrpauvhvnexhintldqhzusndm 410 3 , , , work_fzrpauvhvnexhintldqhzusndm 410 4 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 410 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 410 6 Kusel Kusel NNP work_fzrpauvhvnexhintldqhzusndm 410 7 , , , work_fzrpauvhvnexhintldqhzusndm 410 8 M.M. M.M. NNP work_fzrpauvhvnexhintldqhzusndm 411 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 411 2 Johnston Johnston NNP work_fzrpauvhvnexhintldqhzusndm 411 3 , , , work_fzrpauvhvnexhintldqhzusndm 411 4 S.L. S.L. NNP work_fzrpauvhvnexhintldqhzusndm 412 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 412 2 Gern Gern NNP work_fzrpauvhvnexhintldqhzusndm 412 3 , , , work_fzrpauvhvnexhintldqhzusndm 412 4 J.E. J.E. NNP work_fzrpauvhvnexhintldqhzusndm 413 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 413 2 Lemanske Lemanske NNP work_fzrpauvhvnexhintldqhzusndm 413 3 , , , work_fzrpauvhvnexhintldqhzusndm 413 4 R.F. R.F. NNP work_fzrpauvhvnexhintldqhzusndm 414 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 414 2 et et NNP work_fzrpauvhvnexhintldqhzusndm 414 3 al al NNP work_fzrpauvhvnexhintldqhzusndm 414 4 . . . work_fzrpauvhvnexhintldqhzusndm 415 1 Trajectories trajectory NNS work_fzrpauvhvnexhintldqhzusndm 415 2 of of IN work_fzrpauvhvnexhintldqhzusndm 415 3 childhood childhood NN work_fzrpauvhvnexhintldqhzusndm 415 4 immune immune JJ work_fzrpauvhvnexhintldqhzusndm 415 5 development development NN work_fzrpauvhvnexhintldqhzusndm 415 6 and and CC work_fzrpauvhvnexhintldqhzusndm 415 7 respiratory respiratory JJ work_fzrpauvhvnexhintldqhzusndm 415 8 health health NN work_fzrpauvhvnexhintldqhzusndm 415 9 relevant relevant JJ work_fzrpauvhvnexhintldqhzusndm 415 10 to to IN work_fzrpauvhvnexhintldqhzusndm 415 11 asthma asthma NN work_fzrpauvhvnexhintldqhzusndm 415 12 and and CC work_fzrpauvhvnexhintldqhzusndm 415 13 allergy allergy NN work_fzrpauvhvnexhintldqhzusndm 415 14 . . . work_fzrpauvhvnexhintldqhzusndm 416 1 Elife elife NN work_fzrpauvhvnexhintldqhzusndm 416 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 416 3 , , , work_fzrpauvhvnexhintldqhzusndm 416 4 7 7 CD work_fzrpauvhvnexhintldqhzusndm 416 5 , , , work_fzrpauvhvnexhintldqhzusndm 416 6 28 28 CD work_fzrpauvhvnexhintldqhzusndm 416 7 . . . work_fzrpauvhvnexhintldqhzusndm 417 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 417 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 417 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 417 4 33 33 CD work_fzrpauvhvnexhintldqhzusndm 417 5 . . . work_fzrpauvhvnexhintldqhzusndm 418 1 Piening Piening NNP work_fzrpauvhvnexhintldqhzusndm 418 2 , , , work_fzrpauvhvnexhintldqhzusndm 418 3 B.D. B.D. NNP work_fzrpauvhvnexhintldqhzusndm 419 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 419 2 Zhou Zhou NNP work_fzrpauvhvnexhintldqhzusndm 419 3 , , , work_fzrpauvhvnexhintldqhzusndm 419 4 W. W. NNP work_fzrpauvhvnexhintldqhzusndm 419 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 419 6 Contrepois Contrepois NNP work_fzrpauvhvnexhintldqhzusndm 419 7 , , , work_fzrpauvhvnexhintldqhzusndm 419 8 K. K. NNP work_fzrpauvhvnexhintldqhzusndm 419 9 ; ; : work_fzrpauvhvnexhintldqhzusndm 419 10 Röst Röst NNP work_fzrpauvhvnexhintldqhzusndm 419 11 , , , work_fzrpauvhvnexhintldqhzusndm 419 12 H. H. NNP work_fzrpauvhvnexhintldqhzusndm 419 13 ; ; : work_fzrpauvhvnexhintldqhzusndm 419 14 Gu Gu NNP work_fzrpauvhvnexhintldqhzusndm 419 15 Urban Urban NNP work_fzrpauvhvnexhintldqhzusndm 419 16 , , , work_fzrpauvhvnexhintldqhzusndm 419 17 G.J. G.J. NNP work_fzrpauvhvnexhintldqhzusndm 420 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 420 2 Mishra Mishra NNP work_fzrpauvhvnexhintldqhzusndm 420 3 , , , work_fzrpauvhvnexhintldqhzusndm 420 4 T. T. NNP work_fzrpauvhvnexhintldqhzusndm 420 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 420 6 Hanson Hanson NNP work_fzrpauvhvnexhintldqhzusndm 420 7 , , , work_fzrpauvhvnexhintldqhzusndm 420 8 B.M. B.M. NNP work_fzrpauvhvnexhintldqhzusndm 421 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 421 2 Bautista Bautista NNP work_fzrpauvhvnexhintldqhzusndm 421 3 , , , work_fzrpauvhvnexhintldqhzusndm 421 4 E.J. E.J. NNP work_fzrpauvhvnexhintldqhzusndm 422 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 422 2 Leopold Leopold NNP work_fzrpauvhvnexhintldqhzusndm 422 3 , , , work_fzrpauvhvnexhintldqhzusndm 422 4 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 422 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 422 6 Yeh Yeh NNP work_fzrpauvhvnexhintldqhzusndm 422 7 , , , work_fzrpauvhvnexhintldqhzusndm 422 8 C.Y. C.Y. NNP work_fzrpauvhvnexhintldqhzusndm 423 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 423 2 et et NNP work_fzrpauvhvnexhintldqhzusndm 423 3 al al NNP work_fzrpauvhvnexhintldqhzusndm 423 4 . . . work_fzrpauvhvnexhintldqhzusndm 424 1 Integrative Integrative NNP work_fzrpauvhvnexhintldqhzusndm 424 2 Personal Personal NNP work_fzrpauvhvnexhintldqhzusndm 424 3 Omics Omics NNP work_fzrpauvhvnexhintldqhzusndm 424 4 Profiles Profiles NNPS work_fzrpauvhvnexhintldqhzusndm 424 5 during during IN work_fzrpauvhvnexhintldqhzusndm 424 6 Periods Periods NNP work_fzrpauvhvnexhintldqhzusndm 424 7 of of IN work_fzrpauvhvnexhintldqhzusndm 424 8 Weight Weight NNP work_fzrpauvhvnexhintldqhzusndm 424 9 Gain Gain NNP work_fzrpauvhvnexhintldqhzusndm 424 10 and and CC work_fzrpauvhvnexhintldqhzusndm 424 11 Loss Loss NNP work_fzrpauvhvnexhintldqhzusndm 424 12 . . . work_fzrpauvhvnexhintldqhzusndm 425 1 Cell Cell NNP work_fzrpauvhvnexhintldqhzusndm 425 2 Syst Syst NNP work_fzrpauvhvnexhintldqhzusndm 425 3 . . . work_fzrpauvhvnexhintldqhzusndm 426 1 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 426 2 , , , work_fzrpauvhvnexhintldqhzusndm 426 3 6 6 CD work_fzrpauvhvnexhintldqhzusndm 426 4 , , , work_fzrpauvhvnexhintldqhzusndm 426 5 157–170 157–170 CD work_fzrpauvhvnexhintldqhzusndm 426 6 . . . work_fzrpauvhvnexhintldqhzusndm 427 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 427 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 427 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 427 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 427 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 427 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 427 7 34 34 CD work_fzrpauvhvnexhintldqhzusndm 427 8 . . . work_fzrpauvhvnexhintldqhzusndm 428 1 Peakman Peakman NNP work_fzrpauvhvnexhintldqhzusndm 428 2 , , , work_fzrpauvhvnexhintldqhzusndm 428 3 T. T. NNP work_fzrpauvhvnexhintldqhzusndm 428 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 428 5 Elliott Elliott NNP work_fzrpauvhvnexhintldqhzusndm 428 6 , , , work_fzrpauvhvnexhintldqhzusndm 428 7 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 428 8 Current Current NNP work_fzrpauvhvnexhintldqhzusndm 428 9 standards standard NNS work_fzrpauvhvnexhintldqhzusndm 428 10 for for IN work_fzrpauvhvnexhintldqhzusndm 428 11 the the DT work_fzrpauvhvnexhintldqhzusndm 428 12 storage storage NN work_fzrpauvhvnexhintldqhzusndm 428 13 of of IN work_fzrpauvhvnexhintldqhzusndm 428 14 human human JJ work_fzrpauvhvnexhintldqhzusndm 428 15 samples sample NNS work_fzrpauvhvnexhintldqhzusndm 428 16 in in IN work_fzrpauvhvnexhintldqhzusndm 428 17 biobanks biobank NNS work_fzrpauvhvnexhintldqhzusndm 428 18 . . . work_fzrpauvhvnexhintldqhzusndm 429 1 Genome genome JJ work_fzrpauvhvnexhintldqhzusndm 429 2 Med Med NNP work_fzrpauvhvnexhintldqhzusndm 429 3 . . . work_fzrpauvhvnexhintldqhzusndm 430 1 2010 2010 CD work_fzrpauvhvnexhintldqhzusndm 430 2 , , , work_fzrpauvhvnexhintldqhzusndm 430 3 2 2 CD work_fzrpauvhvnexhintldqhzusndm 430 4 , , , work_fzrpauvhvnexhintldqhzusndm 430 5 72 72 CD work_fzrpauvhvnexhintldqhzusndm 430 6 . . . work_fzrpauvhvnexhintldqhzusndm 431 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 431 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 431 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 431 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 431 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 431 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 431 7 http://dx.doi.org/10.3389/fped.2017.00111 http://dx.doi.org/10.3389/fped.2017.00111 JJ work_fzrpauvhvnexhintldqhzusndm 431 8 http://www.ncbi.nlm.nih.gov/pubmed/28596951 http://www.ncbi.nlm.nih.gov/pubmed/28596951 FW work_fzrpauvhvnexhintldqhzusndm 431 9 http://dx.doi.org/10.1113/jphysiol.2014.271460 http://dx.doi.org/10.1113/jphysiol.2014.271460 UH work_fzrpauvhvnexhintldqhzusndm 431 10 http://www.ncbi.nlm.nih.gov/pubmed/24882817 http://www.ncbi.nlm.nih.gov/pubmed/24882817 JJ work_fzrpauvhvnexhintldqhzusndm 431 11 http://dx.doi.org/10.1016/S0140-6736(18)30312-X http://dx.doi.org/10.1016/S0140-6736(18)30312-X NNP work_fzrpauvhvnexhintldqhzusndm 431 12 http://dx.doi.org/10.1152/physrev.00029.2013 http://dx.doi.org/10.1152/physrev.00029.2013 NNP work_fzrpauvhvnexhintldqhzusndm 431 13 http://www.ncbi.nlm.nih.gov/pubmed/25287859 http://www.ncbi.nlm.nih.gov/pubmed/25287859 FW work_fzrpauvhvnexhintldqhzusndm 431 14 http://dx.doi.org/10.1016/j.jim.2015.04.016 http://dx.doi.org/10.1016/j.jim.2015.04.016 NNP work_fzrpauvhvnexhintldqhzusndm 431 15 http://www.ncbi.nlm.nih.gov/pubmed/25956036 http://www.ncbi.nlm.nih.gov/pubmed/25956036 NN work_fzrpauvhvnexhintldqhzusndm 431 16 http://dx.doi.org/10.1016/j.cell.2018.08.060 http://dx.doi.org/10.1016/j.cell.2018.08.060 NNP work_fzrpauvhvnexhintldqhzusndm 431 17 http://www.ncbi.nlm.nih.gov/pubmed/30241608 http://www.ncbi.nlm.nih.gov/pubmed/30241608 NNP work_fzrpauvhvnexhintldqhzusndm 431 18 http://dx.doi.org/10.1146/annurev-pharmtox-010818-021315 http://dx.doi.org/10.1146/annurev-pharmtox-010818-021315 NNP work_fzrpauvhvnexhintldqhzusndm 431 19 http://dx.doi.org/10.1098/rsif.2017.0391 http://dx.doi.org/10.1098/rsif.2017.0391 NNP work_fzrpauvhvnexhintldqhzusndm 431 20 http://dx.doi.org/10.1371/journal.pcbi.1000140 http://dx.doi.org/10.1371/journal.pcbi.1000140 NNP work_fzrpauvhvnexhintldqhzusndm 431 21 http://dx.doi.org/10.1016/j.cell.2011.10.022 http://dx.doi.org/10.1016/j.cell.2011.10.022 VBD work_fzrpauvhvnexhintldqhzusndm 431 22 http://www.ncbi.nlm.nih.gov/pubmed/22078882 http://www.ncbi.nlm.nih.gov/pubmed/22078882 VB work_fzrpauvhvnexhintldqhzusndm 431 23 http://dx.doi.org/10.1016/j.jaci.2011.10.038 http://dx.doi.org/10.1016/j.jaci.2011.10.038 JJ work_fzrpauvhvnexhintldqhzusndm 431 24 http://www.ncbi.nlm.nih.gov/pubmed/22112518 http://www.ncbi.nlm.nih.gov/pubmed/22112518 NNP work_fzrpauvhvnexhintldqhzusndm 431 25 http://dx.doi.org/10.1038/nrg2918 http://dx.doi.org/10.1038/nrg2918 NNP work_fzrpauvhvnexhintldqhzusndm 431 26 http://dx.doi.org/10.1038/msb4100039 http://dx.doi.org/10.1038/msb4100039 NNP work_fzrpauvhvnexhintldqhzusndm 431 27 http://dx.doi.org/10.1038/nbt.3870 http://dx.doi.org/10.1038/nbt.3870 NNP work_fzrpauvhvnexhintldqhzusndm 431 28 http://www.ncbi.nlm.nih.gov/pubmed/28714965 http://www.ncbi.nlm.nih.gov/pubmed/28714965 NNP work_fzrpauvhvnexhintldqhzusndm 431 29 http://dx.doi.org/10.1186/s13073-017-0489-y http://dx.doi.org/10.1186/s13073-017-0489-y NNP work_fzrpauvhvnexhintldqhzusndm 431 30 http://www.ncbi.nlm.nih.gov/pubmed/29132412 http://www.ncbi.nlm.nih.gov/pubmed/29132412 NNP work_fzrpauvhvnexhintldqhzusndm 431 31 http://dx.doi.org/10.1073/pnas.1721628115 http://dx.doi.org/10.1073/pnas.1721628115 ADD work_fzrpauvhvnexhintldqhzusndm 431 32 http://www.ncbi.nlm.nih.gov/pubmed/29666255 http://www.ncbi.nlm.nih.gov/pubmed/29666255 NNP work_fzrpauvhvnexhintldqhzusndm 431 33 http://dx.doi.org/10.1056/NEJMra1603287 http://dx.doi.org/10.1056/nejmra1603287 PRP$ work_fzrpauvhvnexhintldqhzusndm 431 34 http://dx.doi.org/10.1038/s41576-018-0018-x http://dx.doi.org/10.1038/s41576-018-0018-x NNP work_fzrpauvhvnexhintldqhzusndm 431 35 http://dx.doi.org/10.1038/s41588-018-0183-z http://dx.doi.org/10.1038/s41588-018-0183-z NNP work_fzrpauvhvnexhintldqhzusndm 431 36 http://dx.doi.org/10.7554/eLife.35856 http://dx.doi.org/10.7554/eLife.35856 NNP work_fzrpauvhvnexhintldqhzusndm 431 37 http://dx.doi.org/10.1016/j.cels.2017.12.013 http://dx.doi.org/10.1016/j.cels.2017.12.013 NNP work_fzrpauvhvnexhintldqhzusndm 431 38 http://www.ncbi.nlm.nih.gov/pubmed/29361466 http://www.ncbi.nlm.nih.gov/pubmed/29361466 NNP work_fzrpauvhvnexhintldqhzusndm 431 39 http://dx.doi.org/10.1186/gm193 http://dx.doi.org/10.1186/gm193 XX work_fzrpauvhvnexhintldqhzusndm 431 40 http://www.ncbi.nlm.nih.gov/pubmed/20923579 http://www.ncbi.nlm.nih.gov/pubmed/20923579 NNP work_fzrpauvhvnexhintldqhzusndm 431 41 Challenges Challenges NNP work_fzrpauvhvnexhintldqhzusndm 431 42 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 431 43 , , , work_fzrpauvhvnexhintldqhzusndm 431 44 10 10 CD work_fzrpauvhvnexhintldqhzusndm 431 45 , , , work_fzrpauvhvnexhintldqhzusndm 431 46 23 23 CD work_fzrpauvhvnexhintldqhzusndm 431 47 9 9 CD work_fzrpauvhvnexhintldqhzusndm 431 48 of of IN work_fzrpauvhvnexhintldqhzusndm 431 49 9 9 CD work_fzrpauvhvnexhintldqhzusndm 431 50 35 35 CD work_fzrpauvhvnexhintldqhzusndm 431 51 . . . work_fzrpauvhvnexhintldqhzusndm 432 1 Kolker Kolker NNP work_fzrpauvhvnexhintldqhzusndm 432 2 , , , work_fzrpauvhvnexhintldqhzusndm 432 3 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 432 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 5 Özdemir Özdemir NNP work_fzrpauvhvnexhintldqhzusndm 432 6 , , , work_fzrpauvhvnexhintldqhzusndm 432 7 V. V. NNP work_fzrpauvhvnexhintldqhzusndm 432 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 9 Martens Martens NNP work_fzrpauvhvnexhintldqhzusndm 432 10 , , , work_fzrpauvhvnexhintldqhzusndm 432 11 L. L. NNP work_fzrpauvhvnexhintldqhzusndm 432 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 13 Hancock Hancock NNP work_fzrpauvhvnexhintldqhzusndm 432 14 , , , work_fzrpauvhvnexhintldqhzusndm 432 15 W. W. NNP work_fzrpauvhvnexhintldqhzusndm 432 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 17 Anderson Anderson NNP work_fzrpauvhvnexhintldqhzusndm 432 18 , , , work_fzrpauvhvnexhintldqhzusndm 432 19 G. G. NNP work_fzrpauvhvnexhintldqhzusndm 432 20 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 21 Anderson Anderson NNP work_fzrpauvhvnexhintldqhzusndm 432 22 , , , work_fzrpauvhvnexhintldqhzusndm 432 23 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 432 24 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 25 Aynacioglu Aynacioglu NNP work_fzrpauvhvnexhintldqhzusndm 432 26 , , , work_fzrpauvhvnexhintldqhzusndm 432 27 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 432 28 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 29 Baranova Baranova NNP work_fzrpauvhvnexhintldqhzusndm 432 30 , , , work_fzrpauvhvnexhintldqhzusndm 432 31 A. a. NN work_fzrpauvhvnexhintldqhzusndm 432 32 ; ; : work_fzrpauvhvnexhintldqhzusndm 432 33 Campagna Campagna NNP work_fzrpauvhvnexhintldqhzusndm 432 34 , , , work_fzrpauvhvnexhintldqhzusndm 432 35 S.R. S.R. NNP work_fzrpauvhvnexhintldqhzusndm 433 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 433 2 Chen Chen NNP work_fzrpauvhvnexhintldqhzusndm 433 3 , , , work_fzrpauvhvnexhintldqhzusndm 433 4 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 433 5 ; ; : work_fzrpauvhvnexhintldqhzusndm 433 6 et et NNP work_fzrpauvhvnexhintldqhzusndm 433 7 al al NNP work_fzrpauvhvnexhintldqhzusndm 433 8 . . . work_fzrpauvhvnexhintldqhzusndm 434 1 Toward toward IN work_fzrpauvhvnexhintldqhzusndm 434 2 more more RBR work_fzrpauvhvnexhintldqhzusndm 434 3 transparent transparent JJ work_fzrpauvhvnexhintldqhzusndm 434 4 and and CC work_fzrpauvhvnexhintldqhzusndm 434 5 reproducible reproducible VB work_fzrpauvhvnexhintldqhzusndm 434 6 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 434 7 studies study NNS work_fzrpauvhvnexhintldqhzusndm 434 8 through through IN work_fzrpauvhvnexhintldqhzusndm 434 9 a a DT work_fzrpauvhvnexhintldqhzusndm 434 10 common common JJ work_fzrpauvhvnexhintldqhzusndm 434 11 metadata metadata NN work_fzrpauvhvnexhintldqhzusndm 434 12 checklist checklist NN work_fzrpauvhvnexhintldqhzusndm 434 13 and and CC work_fzrpauvhvnexhintldqhzusndm 434 14 data datum NNS work_fzrpauvhvnexhintldqhzusndm 434 15 publications publication NNS work_fzrpauvhvnexhintldqhzusndm 434 16 . . . work_fzrpauvhvnexhintldqhzusndm 435 1 OMICS omics NN work_fzrpauvhvnexhintldqhzusndm 435 2 2014 2014 CD work_fzrpauvhvnexhintldqhzusndm 435 3 , , , work_fzrpauvhvnexhintldqhzusndm 435 4 18 18 CD work_fzrpauvhvnexhintldqhzusndm 435 5 , , , work_fzrpauvhvnexhintldqhzusndm 435 6 10–14 10–14 CD work_fzrpauvhvnexhintldqhzusndm 435 7 . . . work_fzrpauvhvnexhintldqhzusndm 436 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 436 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 436 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 436 4 36 36 CD work_fzrpauvhvnexhintldqhzusndm 436 5 . . . work_fzrpauvhvnexhintldqhzusndm 437 1 Gomez Gomez NNP work_fzrpauvhvnexhintldqhzusndm 437 2 - - HYPH work_fzrpauvhvnexhintldqhzusndm 437 3 Cabrero Cabrero NNP work_fzrpauvhvnexhintldqhzusndm 437 4 , , , work_fzrpauvhvnexhintldqhzusndm 437 5 D. D. NNP work_fzrpauvhvnexhintldqhzusndm 437 6 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 7 Abugessaisa Abugessaisa NNP work_fzrpauvhvnexhintldqhzusndm 437 8 , , , work_fzrpauvhvnexhintldqhzusndm 437 9 I. I. NNP work_fzrpauvhvnexhintldqhzusndm 437 10 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 11 Maier Maier NNP work_fzrpauvhvnexhintldqhzusndm 437 12 , , , work_fzrpauvhvnexhintldqhzusndm 437 13 D. D. NNP work_fzrpauvhvnexhintldqhzusndm 437 14 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 15 Teschendorff Teschendorff NNP work_fzrpauvhvnexhintldqhzusndm 437 16 , , , work_fzrpauvhvnexhintldqhzusndm 437 17 A. a. NN work_fzrpauvhvnexhintldqhzusndm 437 18 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 19 Merkenschlager Merkenschlager NNP work_fzrpauvhvnexhintldqhzusndm 437 20 , , , work_fzrpauvhvnexhintldqhzusndm 437 21 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 437 22 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 23 Gisel Gisel NNP work_fzrpauvhvnexhintldqhzusndm 437 24 , , , work_fzrpauvhvnexhintldqhzusndm 437 25 A. a. NN work_fzrpauvhvnexhintldqhzusndm 437 26 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 27 Ballestar Ballestar NNP work_fzrpauvhvnexhintldqhzusndm 437 28 , , , work_fzrpauvhvnexhintldqhzusndm 437 29 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 437 30 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 31 Bongcam Bongcam NNP work_fzrpauvhvnexhintldqhzusndm 437 32 - - HYPH work_fzrpauvhvnexhintldqhzusndm 437 33 Rudloff Rudloff NNP work_fzrpauvhvnexhintldqhzusndm 437 34 , , , work_fzrpauvhvnexhintldqhzusndm 437 35 E. E. NNP work_fzrpauvhvnexhintldqhzusndm 437 36 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 37 Conesa Conesa NNP work_fzrpauvhvnexhintldqhzusndm 437 38 , , , work_fzrpauvhvnexhintldqhzusndm 437 39 A. a. NN work_fzrpauvhvnexhintldqhzusndm 437 40 ; ; : work_fzrpauvhvnexhintldqhzusndm 437 41 Tegnér Tegnér NNP work_fzrpauvhvnexhintldqhzusndm 437 42 , , , work_fzrpauvhvnexhintldqhzusndm 437 43 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 438 1 Data datum NNS work_fzrpauvhvnexhintldqhzusndm 438 2 integration integration NN work_fzrpauvhvnexhintldqhzusndm 438 3 in in IN work_fzrpauvhvnexhintldqhzusndm 438 4 the the DT work_fzrpauvhvnexhintldqhzusndm 438 5 era era NN work_fzrpauvhvnexhintldqhzusndm 438 6 of of IN work_fzrpauvhvnexhintldqhzusndm 438 7 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 438 8 : : : work_fzrpauvhvnexhintldqhzusndm 438 9 Current current JJ work_fzrpauvhvnexhintldqhzusndm 438 10 and and CC work_fzrpauvhvnexhintldqhzusndm 438 11 future future JJ work_fzrpauvhvnexhintldqhzusndm 438 12 challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 438 13 . . . work_fzrpauvhvnexhintldqhzusndm 439 1 BMC BMC NNP work_fzrpauvhvnexhintldqhzusndm 439 2 Syst Syst NNP work_fzrpauvhvnexhintldqhzusndm 439 3 . . . work_fzrpauvhvnexhintldqhzusndm 440 1 Biol Biol NNP work_fzrpauvhvnexhintldqhzusndm 440 2 . . . work_fzrpauvhvnexhintldqhzusndm 441 1 2014 2014 CD work_fzrpauvhvnexhintldqhzusndm 441 2 , , , work_fzrpauvhvnexhintldqhzusndm 441 3 8 8 CD work_fzrpauvhvnexhintldqhzusndm 441 4 . . . work_fzrpauvhvnexhintldqhzusndm 442 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 442 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 442 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 442 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 442 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 442 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 442 7 37 37 CD work_fzrpauvhvnexhintldqhzusndm 442 8 . . . work_fzrpauvhvnexhintldqhzusndm 443 1 Chiang Chiang NNP work_fzrpauvhvnexhintldqhzusndm 443 2 , , , work_fzrpauvhvnexhintldqhzusndm 443 3 G.-T. G.-T. NNP work_fzrpauvhvnexhintldqhzusndm 443 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 443 5 Clapham Clapham NNP work_fzrpauvhvnexhintldqhzusndm 443 6 , , , work_fzrpauvhvnexhintldqhzusndm 443 7 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 443 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 443 9 Qi Qi NNP work_fzrpauvhvnexhintldqhzusndm 443 10 , , , work_fzrpauvhvnexhintldqhzusndm 443 11 G. G. NNP work_fzrpauvhvnexhintldqhzusndm 443 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 443 13 Sale Sale NNP work_fzrpauvhvnexhintldqhzusndm 443 14 , , , work_fzrpauvhvnexhintldqhzusndm 443 15 K. K. NNP work_fzrpauvhvnexhintldqhzusndm 443 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 443 17 Coates Coates NNP work_fzrpauvhvnexhintldqhzusndm 443 18 , , , work_fzrpauvhvnexhintldqhzusndm 443 19 G. G. NNP work_fzrpauvhvnexhintldqhzusndm 443 20 Implementing implement VBG work_fzrpauvhvnexhintldqhzusndm 443 21 a a DT work_fzrpauvhvnexhintldqhzusndm 443 22 genomic genomic JJ work_fzrpauvhvnexhintldqhzusndm 443 23 data data NN work_fzrpauvhvnexhintldqhzusndm 443 24 management management NN work_fzrpauvhvnexhintldqhzusndm 443 25 system system NN work_fzrpauvhvnexhintldqhzusndm 443 26 using use VBG work_fzrpauvhvnexhintldqhzusndm 443 27 iRODS irods NN work_fzrpauvhvnexhintldqhzusndm 443 28 in in IN work_fzrpauvhvnexhintldqhzusndm 443 29 the the DT work_fzrpauvhvnexhintldqhzusndm 443 30 Wellcome Wellcome NNP work_fzrpauvhvnexhintldqhzusndm 443 31 Trust Trust NNP work_fzrpauvhvnexhintldqhzusndm 443 32 Sanger Sanger NNP work_fzrpauvhvnexhintldqhzusndm 443 33 Institute Institute NNP work_fzrpauvhvnexhintldqhzusndm 443 34 . . . work_fzrpauvhvnexhintldqhzusndm 444 1 BMC BMC NNP work_fzrpauvhvnexhintldqhzusndm 444 2 Bioinform Bioinform NNP work_fzrpauvhvnexhintldqhzusndm 444 3 . . . work_fzrpauvhvnexhintldqhzusndm 445 1 2011 2011 CD work_fzrpauvhvnexhintldqhzusndm 445 2 , , , work_fzrpauvhvnexhintldqhzusndm 445 3 12 12 CD work_fzrpauvhvnexhintldqhzusndm 445 4 , , , work_fzrpauvhvnexhintldqhzusndm 445 5 361 361 CD work_fzrpauvhvnexhintldqhzusndm 445 6 . . . work_fzrpauvhvnexhintldqhzusndm 446 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 446 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 446 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 446 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 446 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 446 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 446 7 38 38 CD work_fzrpauvhvnexhintldqhzusndm 446 8 . . . work_fzrpauvhvnexhintldqhzusndm 447 1 Schumacher Schumacher NNP work_fzrpauvhvnexhintldqhzusndm 447 2 , , , work_fzrpauvhvnexhintldqhzusndm 447 3 A. a. NN work_fzrpauvhvnexhintldqhzusndm 447 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 447 5 Rujan Rujan NNP work_fzrpauvhvnexhintldqhzusndm 447 6 , , , work_fzrpauvhvnexhintldqhzusndm 447 7 T. T. NNP work_fzrpauvhvnexhintldqhzusndm 447 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 447 9 Genomics Genomics NNP work_fzrpauvhvnexhintldqhzusndm 447 10 , , , work_fzrpauvhvnexhintldqhzusndm 447 11 J.H.A.T. J.H.A.T. NNP work_fzrpauvhvnexhintldqhzusndm 448 1 A a DT work_fzrpauvhvnexhintldqhzusndm 448 2 collaborative collaborative JJ work_fzrpauvhvnexhintldqhzusndm 448 3 approach approach NN work_fzrpauvhvnexhintldqhzusndm 448 4 to to TO work_fzrpauvhvnexhintldqhzusndm 448 5 develop develop VB work_fzrpauvhvnexhintldqhzusndm 448 6 a a DT work_fzrpauvhvnexhintldqhzusndm 448 7 multi multi JJ work_fzrpauvhvnexhintldqhzusndm 448 8 - - HYPH work_fzrpauvhvnexhintldqhzusndm 448 9 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 448 10 data data NNP work_fzrpauvhvnexhintldqhzusndm 448 11 analytics analytic NNS work_fzrpauvhvnexhintldqhzusndm 448 12 platform platform NN work_fzrpauvhvnexhintldqhzusndm 448 13 for for IN work_fzrpauvhvnexhintldqhzusndm 448 14 translational translational JJ work_fzrpauvhvnexhintldqhzusndm 448 15 research research NN work_fzrpauvhvnexhintldqhzusndm 448 16 . . . work_fzrpauvhvnexhintldqhzusndm 449 1 Appl Appl NNP work_fzrpauvhvnexhintldqhzusndm 449 2 . . . work_fzrpauvhvnexhintldqhzusndm 450 1 Transl Transl NNP work_fzrpauvhvnexhintldqhzusndm 450 2 . . . work_fzrpauvhvnexhintldqhzusndm 451 1 Genomics Genomics NNP work_fzrpauvhvnexhintldqhzusndm 451 2 2014 2014 CD work_fzrpauvhvnexhintldqhzusndm 451 3 , , , work_fzrpauvhvnexhintldqhzusndm 451 4 3 3 CD work_fzrpauvhvnexhintldqhzusndm 451 5 , , , work_fzrpauvhvnexhintldqhzusndm 451 6 105–108 105–108 CD work_fzrpauvhvnexhintldqhzusndm 451 7 . . . work_fzrpauvhvnexhintldqhzusndm 452 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 452 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 452 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 452 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 452 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 452 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 452 7 39 39 CD work_fzrpauvhvnexhintldqhzusndm 452 8 . . . work_fzrpauvhvnexhintldqhzusndm 453 1 Hernández Hernández NNP work_fzrpauvhvnexhintldqhzusndm 453 2 - - HYPH work_fzrpauvhvnexhintldqhzusndm 453 3 de de NNP work_fzrpauvhvnexhintldqhzusndm 453 4 - - NNP work_fzrpauvhvnexhintldqhzusndm 453 5 Diego Diego NNP work_fzrpauvhvnexhintldqhzusndm 453 6 , , , work_fzrpauvhvnexhintldqhzusndm 453 7 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 453 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 453 9 Tarazona Tarazona NNP work_fzrpauvhvnexhintldqhzusndm 453 10 , , , work_fzrpauvhvnexhintldqhzusndm 453 11 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 453 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 453 13 Martínez Martínez NNP work_fzrpauvhvnexhintldqhzusndm 453 14 - - HYPH work_fzrpauvhvnexhintldqhzusndm 453 15 Mira Mira NNP work_fzrpauvhvnexhintldqhzusndm 453 16 , , , work_fzrpauvhvnexhintldqhzusndm 453 17 C. C. NNP work_fzrpauvhvnexhintldqhzusndm 453 18 ; ; : work_fzrpauvhvnexhintldqhzusndm 453 19 Balzano Balzano NNP work_fzrpauvhvnexhintldqhzusndm 453 20 - - HYPH work_fzrpauvhvnexhintldqhzusndm 453 21 Nogueira Nogueira NNP work_fzrpauvhvnexhintldqhzusndm 453 22 , , , work_fzrpauvhvnexhintldqhzusndm 453 23 L. L. NNP work_fzrpauvhvnexhintldqhzusndm 453 24 ; ; : work_fzrpauvhvnexhintldqhzusndm 453 25 Furió Furió NNP work_fzrpauvhvnexhintldqhzusndm 453 26 - - HYPH work_fzrpauvhvnexhintldqhzusndm 453 27 Tarí Tarí NNP work_fzrpauvhvnexhintldqhzusndm 453 28 , , , work_fzrpauvhvnexhintldqhzusndm 453 29 P. P. NNP work_fzrpauvhvnexhintldqhzusndm 453 30 ; ; : work_fzrpauvhvnexhintldqhzusndm 453 31 Pappas Pappas NNP work_fzrpauvhvnexhintldqhzusndm 453 32 , , , work_fzrpauvhvnexhintldqhzusndm 453 33 G.J. G.J. NNP work_fzrpauvhvnexhintldqhzusndm 454 1 ; ; : work_fzrpauvhvnexhintldqhzusndm 454 2 Conesa Conesa NNP work_fzrpauvhvnexhintldqhzusndm 454 3 , , , work_fzrpauvhvnexhintldqhzusndm 454 4 A. a. NN work_fzrpauvhvnexhintldqhzusndm 454 5 PaintOmics PaintOmics NNP work_fzrpauvhvnexhintldqhzusndm 454 6 3 3 CD work_fzrpauvhvnexhintldqhzusndm 454 7 : : : work_fzrpauvhvnexhintldqhzusndm 454 8 A a DT work_fzrpauvhvnexhintldqhzusndm 454 9 web web NN work_fzrpauvhvnexhintldqhzusndm 454 10 resource resource NN work_fzrpauvhvnexhintldqhzusndm 454 11 for for IN work_fzrpauvhvnexhintldqhzusndm 454 12 the the DT work_fzrpauvhvnexhintldqhzusndm 454 13 pathway pathway JJ work_fzrpauvhvnexhintldqhzusndm 454 14 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 454 15 and and CC work_fzrpauvhvnexhintldqhzusndm 454 16 visualization visualization NN work_fzrpauvhvnexhintldqhzusndm 454 17 of of IN work_fzrpauvhvnexhintldqhzusndm 454 18 multi multi JJ work_fzrpauvhvnexhintldqhzusndm 454 19 - - HYPH work_fzrpauvhvnexhintldqhzusndm 454 20 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 454 21 data datum NNS work_fzrpauvhvnexhintldqhzusndm 454 22 . . . work_fzrpauvhvnexhintldqhzusndm 455 1 Nucleic Nucleic NNP work_fzrpauvhvnexhintldqhzusndm 455 2 Acids Acids NNPS work_fzrpauvhvnexhintldqhzusndm 455 3 Res Res NNP work_fzrpauvhvnexhintldqhzusndm 455 4 . . . work_fzrpauvhvnexhintldqhzusndm 456 1 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 456 2 , , , work_fzrpauvhvnexhintldqhzusndm 456 3 46 46 CD work_fzrpauvhvnexhintldqhzusndm 456 4 , , , work_fzrpauvhvnexhintldqhzusndm 456 5 W503–W509 W503–W509 NNP work_fzrpauvhvnexhintldqhzusndm 456 6 . . . work_fzrpauvhvnexhintldqhzusndm 457 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 457 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 457 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 457 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 457 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 457 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 457 7 40 40 CD work_fzrpauvhvnexhintldqhzusndm 457 8 . . . work_fzrpauvhvnexhintldqhzusndm 458 1 Rohart Rohart NNP work_fzrpauvhvnexhintldqhzusndm 458 2 , , , work_fzrpauvhvnexhintldqhzusndm 458 3 F. F. NNP work_fzrpauvhvnexhintldqhzusndm 458 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 458 5 Gautier Gautier NNP work_fzrpauvhvnexhintldqhzusndm 458 6 , , , work_fzrpauvhvnexhintldqhzusndm 458 7 B. B. NNP work_fzrpauvhvnexhintldqhzusndm 458 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 458 9 Singh Singh NNP work_fzrpauvhvnexhintldqhzusndm 458 10 , , , work_fzrpauvhvnexhintldqhzusndm 458 11 A. a. NN work_fzrpauvhvnexhintldqhzusndm 458 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 458 13 Cao Cao NNP work_fzrpauvhvnexhintldqhzusndm 458 14 , , , work_fzrpauvhvnexhintldqhzusndm 458 15 K.-A.L. K.-A.L. NNP work_fzrpauvhvnexhintldqhzusndm 459 1 mixOmics mixomic NNS work_fzrpauvhvnexhintldqhzusndm 459 2 : : : work_fzrpauvhvnexhintldqhzusndm 459 3 An an DT work_fzrpauvhvnexhintldqhzusndm 459 4 R r NN work_fzrpauvhvnexhintldqhzusndm 459 5 package package NN work_fzrpauvhvnexhintldqhzusndm 459 6 for for IN work_fzrpauvhvnexhintldqhzusndm 459 7 ‘ ' `` work_fzrpauvhvnexhintldqhzusndm 459 8 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 459 9 feature feature NN work_fzrpauvhvnexhintldqhzusndm 459 10 selection selection NN work_fzrpauvhvnexhintldqhzusndm 459 11 and and CC work_fzrpauvhvnexhintldqhzusndm 459 12 multiple multiple JJ work_fzrpauvhvnexhintldqhzusndm 459 13 data datum NNS work_fzrpauvhvnexhintldqhzusndm 459 14 integration integration NN work_fzrpauvhvnexhintldqhzusndm 459 15 . . . work_fzrpauvhvnexhintldqhzusndm 460 1 PLoS PLoS : work_fzrpauvhvnexhintldqhzusndm 460 2 Comput Comput NNP work_fzrpauvhvnexhintldqhzusndm 460 3 . . . work_fzrpauvhvnexhintldqhzusndm 461 1 Biol Biol NNP work_fzrpauvhvnexhintldqhzusndm 461 2 . . . work_fzrpauvhvnexhintldqhzusndm 462 1 2017 2017 CD work_fzrpauvhvnexhintldqhzusndm 462 2 , , , work_fzrpauvhvnexhintldqhzusndm 462 3 13 13 CD work_fzrpauvhvnexhintldqhzusndm 462 4 , , , work_fzrpauvhvnexhintldqhzusndm 462 5 e1005752 e1005752 CD work_fzrpauvhvnexhintldqhzusndm 462 6 . . . work_fzrpauvhvnexhintldqhzusndm 463 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 463 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 463 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 463 4 41 41 CD work_fzrpauvhvnexhintldqhzusndm 463 5 . . . work_fzrpauvhvnexhintldqhzusndm 464 1 Ghandikota Ghandikota NNP work_fzrpauvhvnexhintldqhzusndm 464 2 , , , work_fzrpauvhvnexhintldqhzusndm 464 3 S. S. NNP work_fzrpauvhvnexhintldqhzusndm 464 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 464 5 Hershey Hershey NNP work_fzrpauvhvnexhintldqhzusndm 464 6 , , , work_fzrpauvhvnexhintldqhzusndm 464 7 G. G. NNP work_fzrpauvhvnexhintldqhzusndm 464 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 464 9 Bioinformatics Bioinformatics NNP work_fzrpauvhvnexhintldqhzusndm 464 10 , , , work_fzrpauvhvnexhintldqhzusndm 464 11 T.M. T.M. NNP work_fzrpauvhvnexhintldqhzusndm 465 1 GENEASE GENEASE NNP work_fzrpauvhvnexhintldqhzusndm 465 2 : : : work_fzrpauvhvnexhintldqhzusndm 465 3 Real real JJ work_fzrpauvhvnexhintldqhzusndm 465 4 time time NN work_fzrpauvhvnexhintldqhzusndm 465 5 bioinformatics bioinformatic NNS work_fzrpauvhvnexhintldqhzusndm 465 6 tool tool NN work_fzrpauvhvnexhintldqhzusndm 465 7 for for IN work_fzrpauvhvnexhintldqhzusndm 465 8 multi multi NNS work_fzrpauvhvnexhintldqhzusndm 465 9 - - NNS work_fzrpauvhvnexhintldqhzusndm 465 10 omics omic NNS work_fzrpauvhvnexhintldqhzusndm 465 11 and and CC work_fzrpauvhvnexhintldqhzusndm 465 12 disease disease NNP work_fzrpauvhvnexhintldqhzusndm 465 13 ontology ontology NNP work_fzrpauvhvnexhintldqhzusndm 465 14 exploration exploration NN work_fzrpauvhvnexhintldqhzusndm 465 15 , , , work_fzrpauvhvnexhintldqhzusndm 465 16 analysis analysis NN work_fzrpauvhvnexhintldqhzusndm 465 17 and and CC work_fzrpauvhvnexhintldqhzusndm 465 18 visualization visualization NN work_fzrpauvhvnexhintldqhzusndm 465 19 . . . work_fzrpauvhvnexhintldqhzusndm 466 1 Bioinformatics Bioinformatics NNP work_fzrpauvhvnexhintldqhzusndm 466 2 2018 2018 CD work_fzrpauvhvnexhintldqhzusndm 466 3 , , , work_fzrpauvhvnexhintldqhzusndm 466 4 34 34 CD work_fzrpauvhvnexhintldqhzusndm 466 5 , , , work_fzrpauvhvnexhintldqhzusndm 466 6 3160–3168 3160–3168 CD work_fzrpauvhvnexhintldqhzusndm 466 7 . . . work_fzrpauvhvnexhintldqhzusndm 467 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 467 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 467 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 467 4 42 42 CD work_fzrpauvhvnexhintldqhzusndm 467 5 . . . work_fzrpauvhvnexhintldqhzusndm 468 1 Wang Wang NNP work_fzrpauvhvnexhintldqhzusndm 468 2 , , , work_fzrpauvhvnexhintldqhzusndm 468 3 B. B. NNP work_fzrpauvhvnexhintldqhzusndm 468 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 468 5 Mezlini Mezlini NNP work_fzrpauvhvnexhintldqhzusndm 468 6 , , , work_fzrpauvhvnexhintldqhzusndm 468 7 A.M. A.M. NNP work_fzrpauvhvnexhintldqhzusndm 468 8 ; ; : work_fzrpauvhvnexhintldqhzusndm 468 9 Demir Demir NNP work_fzrpauvhvnexhintldqhzusndm 468 10 , , , work_fzrpauvhvnexhintldqhzusndm 468 11 F. F. NNP work_fzrpauvhvnexhintldqhzusndm 468 12 ; ; : work_fzrpauvhvnexhintldqhzusndm 468 13 Fiume Fiume NNP work_fzrpauvhvnexhintldqhzusndm 468 14 , , , work_fzrpauvhvnexhintldqhzusndm 468 15 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 468 16 ; ; : work_fzrpauvhvnexhintldqhzusndm 468 17 Tu Tu NNP work_fzrpauvhvnexhintldqhzusndm 468 18 , , , work_fzrpauvhvnexhintldqhzusndm 468 19 Z. Z. NNP work_fzrpauvhvnexhintldqhzusndm 468 20 ; ; : work_fzrpauvhvnexhintldqhzusndm 468 21 Brudno Brudno NNP work_fzrpauvhvnexhintldqhzusndm 468 22 , , , work_fzrpauvhvnexhintldqhzusndm 468 23 M. M. NNP work_fzrpauvhvnexhintldqhzusndm 468 24 ; ; : work_fzrpauvhvnexhintldqhzusndm 468 25 Haibe Haibe NNP work_fzrpauvhvnexhintldqhzusndm 468 26 - - HYPH work_fzrpauvhvnexhintldqhzusndm 468 27 Kains Kains NNP work_fzrpauvhvnexhintldqhzusndm 468 28 , , , work_fzrpauvhvnexhintldqhzusndm 468 29 B. B. NNP work_fzrpauvhvnexhintldqhzusndm 468 30 ; ; : work_fzrpauvhvnexhintldqhzusndm 468 31 Goldenberg Goldenberg NNP work_fzrpauvhvnexhintldqhzusndm 468 32 , , , work_fzrpauvhvnexhintldqhzusndm 468 33 A. a. NN work_fzrpauvhvnexhintldqhzusndm 468 34 Similarity Similarity NNP work_fzrpauvhvnexhintldqhzusndm 468 35 network network NN work_fzrpauvhvnexhintldqhzusndm 468 36 fusion fusion NN work_fzrpauvhvnexhintldqhzusndm 468 37 for for IN work_fzrpauvhvnexhintldqhzusndm 468 38 aggregating aggregate VBG work_fzrpauvhvnexhintldqhzusndm 468 39 data datum NNS work_fzrpauvhvnexhintldqhzusndm 468 40 types type NNS work_fzrpauvhvnexhintldqhzusndm 468 41 on on IN work_fzrpauvhvnexhintldqhzusndm 468 42 a a DT work_fzrpauvhvnexhintldqhzusndm 468 43 genomic genomic JJ work_fzrpauvhvnexhintldqhzusndm 468 44 scale scale NN work_fzrpauvhvnexhintldqhzusndm 468 45 . . . work_fzrpauvhvnexhintldqhzusndm 469 1 Nat Nat NNP work_fzrpauvhvnexhintldqhzusndm 469 2 . . . work_fzrpauvhvnexhintldqhzusndm 470 1 Methods method NNS work_fzrpauvhvnexhintldqhzusndm 470 2 2014 2014 CD work_fzrpauvhvnexhintldqhzusndm 470 3 , , , work_fzrpauvhvnexhintldqhzusndm 470 4 11 11 CD work_fzrpauvhvnexhintldqhzusndm 470 5 , , , work_fzrpauvhvnexhintldqhzusndm 470 6 333–337 333–337 CD work_fzrpauvhvnexhintldqhzusndm 470 7 . . . work_fzrpauvhvnexhintldqhzusndm 471 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 471 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 471 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 471 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 471 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 471 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 471 7 43 43 CD work_fzrpauvhvnexhintldqhzusndm 471 8 . . . work_fzrpauvhvnexhintldqhzusndm 472 1 Gligorijević Gligorijević NNP work_fzrpauvhvnexhintldqhzusndm 472 2 , , , work_fzrpauvhvnexhintldqhzusndm 472 3 V. V. NNP work_fzrpauvhvnexhintldqhzusndm 472 4 ; ; : work_fzrpauvhvnexhintldqhzusndm 472 5 Pržulj Pržulj NNP work_fzrpauvhvnexhintldqhzusndm 472 6 , , , work_fzrpauvhvnexhintldqhzusndm 472 7 N. N. NNP work_fzrpauvhvnexhintldqhzusndm 472 8 Methods Methods NNP work_fzrpauvhvnexhintldqhzusndm 472 9 for for IN work_fzrpauvhvnexhintldqhzusndm 472 10 biological biological JJ work_fzrpauvhvnexhintldqhzusndm 472 11 data datum NNS work_fzrpauvhvnexhintldqhzusndm 472 12 integration integration NN work_fzrpauvhvnexhintldqhzusndm 472 13 : : : work_fzrpauvhvnexhintldqhzusndm 472 14 Perspectives perspective NNS work_fzrpauvhvnexhintldqhzusndm 472 15 and and CC work_fzrpauvhvnexhintldqhzusndm 472 16 challenges challenge NNS work_fzrpauvhvnexhintldqhzusndm 472 17 . . . work_fzrpauvhvnexhintldqhzusndm 473 1 J. J. NNP work_fzrpauvhvnexhintldqhzusndm 473 2 R. R. NNP work_fzrpauvhvnexhintldqhzusndm 473 3 Soc Soc NNP work_fzrpauvhvnexhintldqhzusndm 473 4 . . . work_fzrpauvhvnexhintldqhzusndm 474 1 Interface Interface NNP work_fzrpauvhvnexhintldqhzusndm 474 2 2015 2015 CD work_fzrpauvhvnexhintldqhzusndm 474 3 , , , work_fzrpauvhvnexhintldqhzusndm 474 4 12 12 CD work_fzrpauvhvnexhintldqhzusndm 474 5 , , , work_fzrpauvhvnexhintldqhzusndm 474 6 20150571 20150571 CD work_fzrpauvhvnexhintldqhzusndm 474 7 . . . work_fzrpauvhvnexhintldqhzusndm 475 1 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 475 2 CrossRef CrossRef NNP work_fzrpauvhvnexhintldqhzusndm 475 3 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 475 4 [ [ -LRB- work_fzrpauvhvnexhintldqhzusndm 475 5 PubMed PubMed NNP work_fzrpauvhvnexhintldqhzusndm 475 6 ] ] -RRB- work_fzrpauvhvnexhintldqhzusndm 475 7 © © NNP work_fzrpauvhvnexhintldqhzusndm 475 8 2019 2019 CD work_fzrpauvhvnexhintldqhzusndm 475 9 by by IN work_fzrpauvhvnexhintldqhzusndm 475 10 the the DT work_fzrpauvhvnexhintldqhzusndm 475 11 authors author NNS work_fzrpauvhvnexhintldqhzusndm 475 12 . . . work_fzrpauvhvnexhintldqhzusndm 476 1 Licensee Licensee NNP work_fzrpauvhvnexhintldqhzusndm 476 2 MDPI MDPI NNP work_fzrpauvhvnexhintldqhzusndm 476 3 , , , work_fzrpauvhvnexhintldqhzusndm 476 4 Basel Basel NNP work_fzrpauvhvnexhintldqhzusndm 476 5 , , , work_fzrpauvhvnexhintldqhzusndm 476 6 Switzerland Switzerland NNP work_fzrpauvhvnexhintldqhzusndm 476 7 . . . work_fzrpauvhvnexhintldqhzusndm 477 1 This this DT work_fzrpauvhvnexhintldqhzusndm 477 2 article article NN work_fzrpauvhvnexhintldqhzusndm 477 3 is be VBZ work_fzrpauvhvnexhintldqhzusndm 477 4 an an DT work_fzrpauvhvnexhintldqhzusndm 477 5 open open JJ work_fzrpauvhvnexhintldqhzusndm 477 6 access access NN work_fzrpauvhvnexhintldqhzusndm 477 7 article article NN work_fzrpauvhvnexhintldqhzusndm 477 8 distributed distribute VBN work_fzrpauvhvnexhintldqhzusndm 477 9 under under IN work_fzrpauvhvnexhintldqhzusndm 477 10 the the DT work_fzrpauvhvnexhintldqhzusndm 477 11 terms term NNS work_fzrpauvhvnexhintldqhzusndm 477 12 and and CC work_fzrpauvhvnexhintldqhzusndm 477 13 conditions condition NNS work_fzrpauvhvnexhintldqhzusndm 477 14 of of IN work_fzrpauvhvnexhintldqhzusndm 477 15 the the DT work_fzrpauvhvnexhintldqhzusndm 477 16 Creative Creative NNP work_fzrpauvhvnexhintldqhzusndm 477 17 Commons Commons NNP work_fzrpauvhvnexhintldqhzusndm 477 18 Attribution Attribution NNP work_fzrpauvhvnexhintldqhzusndm 477 19 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 477 20 CC CC NNP work_fzrpauvhvnexhintldqhzusndm 477 21 BY BY NNP work_fzrpauvhvnexhintldqhzusndm 477 22 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 477 23 license license NN work_fzrpauvhvnexhintldqhzusndm 477 24 ( ( -LRB- work_fzrpauvhvnexhintldqhzusndm 477 25 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ ADD work_fzrpauvhvnexhintldqhzusndm 477 26 ) ) -RRB- work_fzrpauvhvnexhintldqhzusndm 477 27 . . . work_fzrpauvhvnexhintldqhzusndm 478 1 http://dx.doi.org/10.1089/omi.2013.0149 http://dx.doi.org/10.1089/omi.2013.0149 NFP work_fzrpauvhvnexhintldqhzusndm 478 2 http://dx.doi.org/10.1186/1752-0509-8-S2-I1 http://dx.doi.org/10.1186/1752-0509-8-S2-I1 NNP work_fzrpauvhvnexhintldqhzusndm 478 3 http://www.ncbi.nlm.nih.gov/pubmed/25032990 http://www.ncbi.nlm.nih.gov/pubmed/25032990 NN work_fzrpauvhvnexhintldqhzusndm 478 4 http://dx.doi.org/10.1186/1471-2105-12-361 http://dx.doi.org/10.1186/1471-2105-12-361 NN work_fzrpauvhvnexhintldqhzusndm 478 5 http://www.ncbi.nlm.nih.gov/pubmed/21906284 http://www.ncbi.nlm.nih.gov/pubmed/21906284 `` work_fzrpauvhvnexhintldqhzusndm 478 6 http://dx.doi.org/10.1016/j.atg.2014.09.010 http://dx.doi.org/10.1016/j.atg.2014.09.010 NNP work_fzrpauvhvnexhintldqhzusndm 478 7 http://www.ncbi.nlm.nih.gov/pubmed/27294023 http://www.ncbi.nlm.nih.gov/pubmed/27294023 NN work_fzrpauvhvnexhintldqhzusndm 478 8 http://dx.doi.org/10.1093/nar/gky466 http://dx.doi.org/10.1093/nar/gky466 ADD work_fzrpauvhvnexhintldqhzusndm 478 9 http://www.ncbi.nlm.nih.gov/pubmed/29800320 http://www.ncbi.nlm.nih.gov/pubmed/29800320 RB work_fzrpauvhvnexhintldqhzusndm 478 10 http://dx.doi.org/10.1371/journal.pcbi.1005752 http://dx.doi.org/10.1371/journal.pcbi.1005752 XX work_fzrpauvhvnexhintldqhzusndm 478 11 http://dx.doi.org/10.1093/bioinformatics/bty182 http://dx.doi.org/10.1093/bioinformatics/bty182 NNP work_fzrpauvhvnexhintldqhzusndm 478 12 http://dx.doi.org/10.1038/nmeth.2810 http://dx.doi.org/10.1038/nmeth.2810 NN work_fzrpauvhvnexhintldqhzusndm 478 13 http://www.ncbi.nlm.nih.gov/pubmed/24464287 http://www.ncbi.nlm.nih.gov/pubmed/24464287 UH work_fzrpauvhvnexhintldqhzusndm 478 14 http://dx.doi.org/10.1098/rsif.2015.0571 http://dx.doi.org/10.1098/rsif.2015.0571 UH work_fzrpauvhvnexhintldqhzusndm 478 15 http://www.ncbi.nlm.nih.gov/pubmed/26490630 http://www.ncbi.nlm.nih.gov/pubmed/26490630 NNP work_fzrpauvhvnexhintldqhzusndm 478 16 http://creativecommons.org/ http://creativecommons.org/ NNP work_fzrpauvhvnexhintldqhzusndm 478 17 http://creativecommons.org/licenses/by/4.0/. http://creativecommons.org/licenses/by/4.0/. NNP work_fzrpauvhvnexhintldqhzusndm 479 1 Introduction introduction NN work_fzrpauvhvnexhintldqhzusndm 479 2 Perinatal Perinatal NNP work_fzrpauvhvnexhintldqhzusndm 479 3 Influences Influences NNPS work_fzrpauvhvnexhintldqhzusndm 479 4 on on IN work_fzrpauvhvnexhintldqhzusndm 479 5 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 479 6 Development Development NNP work_fzrpauvhvnexhintldqhzusndm 479 7 and and CC work_fzrpauvhvnexhintldqhzusndm 479 8 Chronic Chronic NNP work_fzrpauvhvnexhintldqhzusndm 479 9 Disease Disease NNP work_fzrpauvhvnexhintldqhzusndm 479 10 Moving Moving NNP work_fzrpauvhvnexhintldqhzusndm 479 11 beyond beyond IN work_fzrpauvhvnexhintldqhzusndm 479 12 Reductionist Reductionist NNP work_fzrpauvhvnexhintldqhzusndm 479 13 Biology Biology NNP work_fzrpauvhvnexhintldqhzusndm 479 14 : : : work_fzrpauvhvnexhintldqhzusndm 479 15 Systems system NNS work_fzrpauvhvnexhintldqhzusndm 479 16 - - HYPH work_fzrpauvhvnexhintldqhzusndm 479 17 Level level NN work_fzrpauvhvnexhintldqhzusndm 479 18 Understanding understanding NN work_fzrpauvhvnexhintldqhzusndm 479 19 of of IN work_fzrpauvhvnexhintldqhzusndm 479 20 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 479 21 Dysregulation Dysregulation NNP work_fzrpauvhvnexhintldqhzusndm 479 22 Utilizing Utilizing NNP work_fzrpauvhvnexhintldqhzusndm 479 23 Systems Systems NNPS work_fzrpauvhvnexhintldqhzusndm 479 24 Biology Biology NNP work_fzrpauvhvnexhintldqhzusndm 479 25 Approaches Approaches NNP work_fzrpauvhvnexhintldqhzusndm 479 26 for for IN work_fzrpauvhvnexhintldqhzusndm 479 27 Very very RB work_fzrpauvhvnexhintldqhzusndm 479 28 Early Early NNP work_fzrpauvhvnexhintldqhzusndm 479 29 Prediction Prediction NNP work_fzrpauvhvnexhintldqhzusndm 479 30 and and CC work_fzrpauvhvnexhintldqhzusndm 479 31 Intervention Intervention NNP work_fzrpauvhvnexhintldqhzusndm 479 32 for for IN work_fzrpauvhvnexhintldqhzusndm 479 33 Immune Immune NNP work_fzrpauvhvnexhintldqhzusndm 479 34 - - HYPH work_fzrpauvhvnexhintldqhzusndm 479 35 Mediated mediate VBN work_fzrpauvhvnexhintldqhzusndm 479 36 Diseases Diseases NNP work_fzrpauvhvnexhintldqhzusndm 479 37 Multiomic Multiomic NNP work_fzrpauvhvnexhintldqhzusndm 479 38 Studies Studies NNPS work_fzrpauvhvnexhintldqhzusndm 479 39 : : : work_fzrpauvhvnexhintldqhzusndm 479 40 Challenges Challenges NNPS work_fzrpauvhvnexhintldqhzusndm 479 41 and and CC work_fzrpauvhvnexhintldqhzusndm 479 42 Opportunities Opportunities NNPS work_fzrpauvhvnexhintldqhzusndm 479 43 Sample Sample NNP work_fzrpauvhvnexhintldqhzusndm 479 44 Collection Collection NNP work_fzrpauvhvnexhintldqhzusndm 479 45 Data Data NNP work_fzrpauvhvnexhintldqhzusndm 479 46 Collection Collection NNP work_fzrpauvhvnexhintldqhzusndm 479 47 Data Data NNP work_fzrpauvhvnexhintldqhzusndm 479 48 Management Management NNP work_fzrpauvhvnexhintldqhzusndm 479 49 Data Data NNP work_fzrpauvhvnexhintldqhzusndm 479 50 Analysis Analysis NNP work_fzrpauvhvnexhintldqhzusndm 479 51 Concluding Concluding NNP work_fzrpauvhvnexhintldqhzusndm 479 52 Remarks Remarks NNP work_fzrpauvhvnexhintldqhzusndm 479 53 References reference NNS