id author title date pages extension mime words sentences flesch summary cache txt work_uby2bb3iifaxrjobyckqtnpkpe Omer T. Njajou A Common Variant in the Telomerase RNA Component Is Associated with Short Telomere Length 2010.0 7 .pdf application/pdf 5879 719 65 A common variant in the telomerase RNA component is associated with short telomere the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the populationbased Health Aging and Body Composition (Health ABC) Study and in two replication samples (the TwinsUK Study and the Methodology: Five variants were identified in the TERC region by sequence analysis and only one SNP was common was replicated in another white sample from the TwinsUK Study (6.9060.03 kbp in 301 carriers compared to 7.0660.03 kbp family-based AFOS and blacks from the Health ABC cohort, although not statistically significant, possibly due to the lower Conclusion: Our study shows a significant association between a common variant in TERC and TL in humans, suggesting *Based on a dominant genetic model for the G allele, adjusted for age, sex, relatedness, telomere length assay batch. variants near TERC are associated with mean telomere length. ./cache/work_uby2bb3iifaxrjobyckqtnpkpe.pdf ./txt/work_uby2bb3iifaxrjobyckqtnpkpe.txt