id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_sqxob7oiabbsjeegz7pl4bo7hy	Zhiguo Chen	Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma	2014.0	12	.pdf	application/pdf	9754	838	66	Using cell-lineage tracing, we identify a population of GAP43+ PLP+ precursors in embryonic nerve roots as the cells of origin for these tumors and report a non-germline neurofibroma model for preclinical drug screening to identify effective therapies. nal nerve roots are the cells of origin for plexiform neurofibroma However, the exact developmental stage and embryonic location of the Schwann cell lineage that initiate neurofibroma formation remain unknown. In genetic mouse models, Nf1 ablation in embryonic Schwann cell lineage (PLP, Krox20, and DHH positive cells) Plexiform Neurofibromas Are inside the Embryonic PLP+ Nerve Root Cells might be the embryonic neurofibroma tumor cells of origin. the embryonic nerve roots as the cells of origin for plexiform Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma Cells of Origin in the Embryonic Nerve Roots for NF1-Associated Plexiform Neurofibroma Loss of Nf1 in Embryonic DRG/Nerve Root Neurosphere Cells Gives Rise to Classic Plexiform Neurofibroma In Vivo	./cache/work_sqxob7oiabbsjeegz7pl4bo7hy.pdf	./txt/work_sqxob7oiabbsjeegz7pl4bo7hy.txt