id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_qknf4j2hpbdydh62l5zsecrctm	Marten H Hofker	APOC3 deficiency: from mice to man	2009.0	2	.pdf	application/pdf	1255	86	57	APOC3 null mutation affects lipoprotein profile European Journal of Human Genetics (2010) 18, 1–2; doi:10.1038/ejhg.2009.126; lipoprotein metabolism were cloned, including the genes encoding the apolipoproteins. APOC3 is located in a gene cluster – together sequence variation in the promoters and regulatory elements of APOC3 and APOA5 independently affects triglyceride levels.4 However, heterozygous deficiency of the APOC3 gene screened for mutations in lipoprotein genes. allele frequency (0.028) was strongly associated with low fasting triglyceride levels 800 kb from the APOC3 gene cluster. proximity of the SNPs and the APOC3 gene cluster, and given the phenotype that predicted a function for APOC3, this gene was away from the APOC3 gene cluster was Other genes with an established function in lipoprotein metabolism from rodent studies and also human genetic conclusion of this paper that the APOC3 gene of variation within the APOC3/A4/A5 gene cluster APOC3 deficiency: from mice to man APOC3 deficiency: from mice to man	./cache/work_qknf4j2hpbdydh62l5zsecrctm.pdf	./txt/work_qknf4j2hpbdydh62l5zsecrctm.txt