id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_q552zk7xqfgv5j5puzb7lie3y4	Michael D. Kessler	De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population	2020.0	11	.pdf	application/pdf	13973	2164	66	significantly fewer DNMs in Amish individuals, even when compared with other Europeans, and even after accounting for parental age and sequencing center. Amish, which seem to underpin their overall reduction in DNMs. Finally, we calculated near-zero estimates of narrow sense heritability (h2), which suggest that variation in DNM rate is significantly DNM counts and rates across five TOPMed cohorts that represent European, African, and Native American (Latino) ancestry individuals, and that include Amish individuals from a and then test whether mutation rate is a heritable trait in anticipation of using genome-wide association studies (GWAS) to call set to date, and use it to quantify the genome-wide relationship between local mutation rate and population-level and mutation rate estimates explain the distribution of genomic variation seen at the human population level. per chromosome can explain between 60% and 72% of the variation in rare variant totals across chromosomes that have segments with high local DNM rates (chrs 8, 9, 16, and 19) (Table	./cache/work_q552zk7xqfgv5j5puzb7lie3y4.pdf	./txt/work_q552zk7xqfgv5j5puzb7lie3y4.txt