id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_pbrvjcs2gfftroz7ba3ceecxp4	Sadiya S. Khan	A null mutation in SERPINE1 protects against biological aging in humans	2017.0	9	.pdf	application/pdf	9626	1141	66	Heterozygosity was associated with significantly longer leukocyte telomere length, lower fasting insulin levels, and lower prevalence of diabetes mellitus. Therefore, we tested the association of carrier status for the null SERPINE1 mutation with LTL as Association of SERPINE1 genotype status and leukocyte telomere length as a function of age in the Berne Amish kindred. Every 1-year increase in age of study participant was associated with a 0.0087 lower relative LTL (P < 0.0001) and a 30–base pair lower the aging composite scores, including brachial pulse pressure (A), e′ velocity (B), and carotid IMT (C) as a function age in Amish participants by genotype status for SERPINE1 null Future studies will provide the opportunity to investigate the contribution of PAI-1 to individual telomere attrition over time, the development of incident diabetes and other age-related diseases, and perhaps Association of biological aging composite scores including telomere length with 5-year	./cache/work_pbrvjcs2gfftroz7ba3ceecxp4.pdf	./txt/work_pbrvjcs2gfftroz7ba3ceecxp4.txt