id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ot5gnjmwkjg3fpx4xu23qzbdnq	Frank B. Livingstone	The founder effect and deleterious genes	1969.0	5	.pdf	application/pdf	3138	342	73	single deleterious gene i n a founder can attain an appreciable frequency i n later in their frequencies in present major human populations may be due to the founder Many of the tri-racial isolates of Eastern United States also have a high frequency of a deleterious gene (Witkop et al., original small size of the isolate could account for the high frequency of the deleterious gene. frequencies of deleterious genes with various models of population expansion. The occurrence which initiated this research is the gene for sickle cell hemoglobin in the Brandywine isolate of Southeast The high frequency i n the Brandywine isolate may have a similar explanation, but the surrounding Negro population with the sickle cell trait, 16% of the populations have the gene at a frequency of carrier of the lethal gene and the population doubled itself for five generations, so a few founders should have such high frequencies of lethal genes seems to indicate 	./cache/work_ot5gnjmwkjg3fpx4xu23qzbdnq.pdf	./txt/work_ot5gnjmwkjg3fpx4xu23qzbdnq.txt