id author title date pages extension mime words sentences flesch summary cache txt work_onvgw2o7o5f4blaowkrzrb5xhq Jacob L McCauley Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish 2006.0 9 .pdf application/pdf 7923 872 42 Methods: We recently performed a genome scan of dementia in this population that detected several potential loci. examination of genotype frequencies identified 21 markers (5%) nominally (p ≤ 0.05) associated with dementia; the most Conclusion: Our results provide the initial groundwork for identifying genes involved in late-onset Alzheimer's disease there may be a number of LOAD susceptibility genes contributing to disease in the general population, the relatively homogeneous Amish population is likely to contain By genetically evaluating case and control individuals selected from such a population, whose common 183 cM where we find evidence for both allele and genotype differences between our dementia cases and controls genome-wide linkage study within the Amish population, NL, Siddique T, Vance JM, Conneally PM, Roses AD: Genetic linkage studies in Alzheimer's disease families. MA: Fine mapping of the chromosome 12 late-onset alzheimer disease locus: potential genetic and phenotypic heterogeneity. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. ./cache/work_onvgw2o7o5f4blaowkrzrb5xhq.pdf ./txt/work_onvgw2o7o5f4blaowkrzrb5xhq.txt