id author title date pages extension mime words sentences flesch summary cache txt work_nkq3e5dee5fp7j4izjbewmi3di S. K. Das Linkage and Association Mapping of a Chromosome 1q21-q24 Type 2 Diabetes Susceptibility Locus in Northern European Caucasians 2004.0 8 .pdf application/pdf 8244 557 58 We tested linkage by parametric and nonparametric approaches and association using both casecontrol and family-based methods. families that provided the previous evidence for linkage, the highest parametric, recessive logarithm of odds sib-pairs (18) have identified linkage of type 2 diabetes to was to localize the well-replicated type 2 diabetes susceptibility gene in this region using a dense microsatellite map linkage peak from other laboratories and unpublished data from our laboratory suggesting associations in multiple locations, we considered the possibility that multiple susceptibility loci might be present and that these loci Control individuals included spouses from linkage families who had normal glucose tolerance tests (108 subjects) and Caucasian were included for all markers for both linkage and association studies. To further localize the type 2 diabetes susceptibility locus, we tested association in a Marker D1S194, which was associated with type 2 diabetes in the case-control study, lies just ./cache/work_nkq3e5dee5fp7j4izjbewmi3di.pdf ./txt/work_nkq3e5dee5fp7j4izjbewmi3di.txt