id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_lji673kzszf5ncaphne47uodc4	Dinna N. Cruz	Mutations in the Na-Cl Cotransporter Reduce Blood Pressure in Humans	2001.0	7	.pdf	application/pdf	5317	372	51	mutations that increase renal salt balance lead to higher blood pressure, suggesting that mutations that decrease the net We hypothesized that the mild salt wasting of Gitelman's syndrome results in reduced blood pressure In addition, the NCCT genotype was a significant predictor of blood pressure, with homozygous mutant family members having significantly lower ageand gender-adjusted systolic and diastolic blood pressures than 24-hour urinary Na1 than did wild-type subjects, reflecting a self-selected higher salt intake. children, but not adults, had significantly lower blood pressures than those of the wild-type relatives. provide formal demonstration that inherited mutations that impair renal salt handling lower blood pressure in humans. significant (P50.002), with genotypically affected individuals having ageand gender-adjusted diastolic blood pressures Effect of NCCT mutations on blood pressure. pressures for members of kindred K140 with different NCCT genotypes are shown. defective copies of NCCT have blood pressure that is significantly lower than that of their wild-type relatives.	./cache/work_lji673kzszf5ncaphne47uodc4.pdf	./txt/work_lji673kzszf5ncaphne47uodc4.txt