id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ksylcvhnbnh7jf2ejjowyebtpm	Eleftheria Zeggini	Using genetically isolated populations to understand the genomic basis of disease	2014.0	3	.pdf	application/pdf	1870	145	48	Genetically isolated or founder populations have recently isolated population cohorts often provide the opportunity to recall subjects by genotype, access detailed genealogical records, obtain linkage to health records and variant was carried by approximately 4% of the individuals studied and reached genome-wide statistical significance with a sample size of fewer than 1,300. A prime example of how founder population characteristics coupled with linkage to medical records can accelerate discovery was recently produced by studying the provide a unique and powerful resource for the identification of low frequency and rare variants of direct detect a significant accumulation of rare variants at particular loci is further increased in founder populations as designing rare variant association studies. 3. Zeggini E: Next-generation association studies for complex traits. Cite this article as: Zeggini: Using genetically isolated populations to Complex trait locus discovery in isolated populations	./cache/work_ksylcvhnbnh7jf2ejjowyebtpm.pdf	./txt/work_ksylcvhnbnh7jf2ejjowyebtpm.txt