id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_kpf7atny2rfvjiwnovaidvndry	Miguel Valderrábano	The Tell-Tale Heart (Now, Optically Mapped)⁎⁎Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology	2010.0	2	.pdf	application/pdf	1873	285	70	olecular origins of pacemaker automaticity to the anaomic and physiologic mechanisms of macroscopic propaation of the sinus node impulse to neighboring atrial tissue. Editorials published in the Journal of the American College of Cardiology reflect the How does the SAN manage to take depolarizaion from a small group of cells into the entire atrial tissue? The slow conduction within the SAN supports unoupling as a mechanism of slow-but-safe propagation. ocalized cooling, observed that initial atrial activation sites iscrete conduction pathways connecting the SAN with acemaker cells, propagation within the SAN would fail due intracellular Ca2� clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. of the pacemaker tissues of the heart. Ca2� clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function. Relation to dynamics of atrial conduction, P-wave changes and heart rate control. ey Words: bradycardia y exit pathway y optical mapping y sinus node.	./cache/work_kpf7atny2rfvjiwnovaidvndry.pdf	./txt/work_kpf7atny2rfvjiwnovaidvndry.txt