id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_kmmrtdanmnds7mkac2jovjkceq	Claire E. Gibbons	Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells	2008.0	31	.pdf	application/pdf	6398	921	67	Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell Together, these data implicate CaR activation and a lithiuminhibitable signalling pathway in the induction of cell death by gentamicin in renal kidney (OK) cells express a calcium-sensing receptor (CaR)-like protein and elicit tested whether lithium could ameliorate gentamicin-induced toxicity in OK and CaRHEK cells, and whether it did so by affecting drug uptake or not. systemic effect, we studied gentamicin-induced cell death in both OK cells and CaRHEK cells in the presence or absence of the clinical target concentration of LiCl (1mM). XI inhibited (500µM) gentamicin-induced cell death in CaR-HEK (Figure 7A) and OK gentamicin concentrations, the drug elicits significant apoptotic cell death in CaR-HEK We also demonstrated a protective effect of lithium on gentamicin-induced cell also inhibited gentamicin-induced CaR-HEK and OK cell toxicity. Cotreatment with lithium ameliorates gentamicin-induced cell death in 	./cache/work_kmmrtdanmnds7mkac2jovjkceq.pdf	./txt/work_kmmrtdanmnds7mkac2jovjkceq.txt