id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_kcqmtroysnbffjrkrrkhjxjglu	Inga Prokopenko	A Central Role for GRB10 in Regulation of Islet Function in Man	2014.0	13	.pdf	application/pdf	11529	1043	59	Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but Funding: Studies at LUDC in Malmö (DGI, BPS, PPP, MPP and human islets) were supported by grants from the Swedish Research Council (SFO EXODIAB: Dnr 2009have here performed the first large-scale meta-analysis for glucosestimulated insulin secretion (GSIS) during an oral glucose association (p,561028) with insulin secretion measured as corrected insulin response (CIR) to glucose at 30 min during an OGTT for We also observe tissuespecific differences in DNA methylation and allelic imbalance in expression of GRB10 in human pancreatic islets. SNPs associated with primary insulin secretion traits at genome-wide significance levels. SNPs tested for association with insulin secretion measured as CIR and AUCIns/AUCGluc (trait abbreviations are listed in the Methods ''Phenotype definition'' section). Parent-of-origin effect of GRB10 rs933360 on insulin secretion and glucose levels.	./cache/work_kcqmtroysnbffjrkrrkhjxjglu.pdf	./txt/work_kcqmtroysnbffjrkrrkhjxjglu.txt